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Search of human proteins with 109240556
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
(641 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 1261 0.0
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 753 0.0
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 750 0.0
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 750 0.0
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 690 0.0
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 575 e-164
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 487 e-137
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 485 e-137
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 130 4e-30
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 119 1e-26
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 112 1e-24
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 108 2e-23
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 102 1e-21
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 97 3e-20
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 97 3e-20
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 95 2e-19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 95 2e-19
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 89 1e-17
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 88 2e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 87 5e-17
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 86 1e-16
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 83 9e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 82 2e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 82 2e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 82 2e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 82 2e-15
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 81 3e-15
gi|31982906 cingulin-like 1 [Homo sapiens] 81 3e-15
gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens] 80 4e-15
gi|4504063 golgin 97 [Homo sapiens] 79 1e-14
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 1261 bits (3262), Expect = 0.0
Identities = 641/641 (100%), Positives = 641/641 (100%)
Query: 1 MTFQVWGWRREDASQVLAWVPDAEGGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGL 60
MTFQVWGWRREDASQVLAWVPDAEGGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGL
Sbjct: 1 MTFQVWGWRREDASQVLAWVPDAEGGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGL 60
Query: 61 IESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEA 120
IESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEA
Sbjct: 61 IESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEA 120
Query: 121 EEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEE 180
EEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEE
Sbjct: 121 EEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEE 180
Query: 181 EGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQ 240
EGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQ
Sbjct: 181 EGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQ 240
Query: 241 KNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLI 300
KNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLI
Sbjct: 241 KNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLI 300
Query: 301 LMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM 360
LMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM
Sbjct: 301 LMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM 360
Query: 361 KHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARL 420
KHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARL
Sbjct: 361 KHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARL 420
Query: 421 EEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQL 480
EEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQL
Sbjct: 421 EEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQL 480
Query: 481 ETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQE 540
ETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQE
Sbjct: 481 ETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQE 540
Query: 541 QALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNC 600
QALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNC
Sbjct: 541 QALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNC 600
Query: 601 GEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSNLP 641
GEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSNLP
Sbjct: 601 GEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSNLP 641
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 753 bits (1945), Expect = 0.0
Identities = 381/614 (62%), Positives = 478/614 (77%), Gaps = 1/614 (0%)
Query: 25 GGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVV 84
GG G T R+ A+K ERANL++M KLSIK L++SALS GR+LD+D+ PLQQFFVV
Sbjct: 93 GGDSGDGTARA-ASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVV 151
Query: 85 MEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWL 144
MEHCLKHGLKV+KSF+ NK+ +GPLELVEKL PEA +I SVR+LP LKT +GR RAWL
Sbjct: 152 MEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWL 211
Query: 145 RLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGE 204
LALMQKK+ADYL+ LI + LLSEFYE ALMMEEEG VIVGLLVGLNV+DANLC+KGE
Sbjct: 212 YLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGE 271
Query: 205 DLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDS 264
DLDSQVGVIDFS+YLK+ +D+ + + +I +LDQKNYVEELNR L+ TV L +++D
Sbjct: 272 DLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDG 331
Query: 265 LEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKH 324
LEK+N+KL EEL+ A + I LQEE QLR +N+LI ++++ +E+TK D + EL+TYK
Sbjct: 332 LEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQ 391
Query: 325 SRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIG 384
+RQGLDEMY++ +QL++E ++R ++E EL +Q+ MK E+E+AMKLLEKD HEKQDTL+
Sbjct: 392 TRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVA 451
Query: 385 LRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKA 444
LRQQLEEVKAIN++M+ K Q +E L++KNE I E KTN++ ++M+Q+E+RLQ +E+A
Sbjct: 452 LRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERA 511
Query: 445 QMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDA 504
+ AE+ K QE + +LQ Q+SQ +Q LE +LK EKE RQ LQ +LQ EKD
Sbjct: 512 RQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDT 571
Query: 505 LSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEAN 564
S LR E QQ+ LKKE LQDE +L+KI EQEQALQE+G LS+SKLK+EDIKE N
Sbjct: 572 SSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVN 631
Query: 565 KALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRV 624
+AL+G WLKD EATHC+ CEKEFS+S+RKHHCRNCG IFCN CS NEL LPS PKPVRV
Sbjct: 632 QALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRV 691
Query: 625 CDSCHALLIQRCSS 638
CDSCH LL+QRCSS
Sbjct: 692 CDSCHTLLLQRCSS 705
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 750 bits (1937), Expect = 0.0
Identities = 374/594 (62%), Positives = 469/594 (78%)
Query: 45 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNK 104
ERANL++M KLSIK L++SALS GR+LD+D+ PLQQFFVVMEHCLKHGLKV+KSF+ NK
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNK 63
Query: 105 TIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQR 164
+ +GPLELVEKL PEA +I SVR+LP LKT +GR RAWL LALMQKK+ADYL+ LI +
Sbjct: 64 SFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNK 123
Query: 165 DLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEED 224
LLSEFYE ALMMEEEG VIVGLLVGLNV+DANLC+KGEDLDSQVGVIDFS+YLK+ +D
Sbjct: 124 HLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQD 183
Query: 225 IGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNII 284
+ + + +I +LDQKNYVEELNR L+ TV L +++D LEK+N+KL EEL+ A + I
Sbjct: 184 LDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRIC 243
Query: 285 KLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDES 344
LQEE QLR +N+LI ++++ +E+TK D + EL+TYK +RQGLDEMY++ +QL++E
Sbjct: 244 SLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 303
Query: 345 QLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQ 404
++R ++E EL +Q+ MK E+E+AMKLLEKD HEKQDTL+ LRQQLEEVKAIN++M+ K Q
Sbjct: 304 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 363
Query: 405 GSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSD 464
+E L++KNE I E KTN++ ++M+Q+E+RLQ +E+A+ AE+ K QE +
Sbjct: 364 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIG 423
Query: 465 SLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLN 524
+LQ Q+SQ +Q LE +LK EKE RQ LQ +LQ EKD S LR E QQ+ LKKE
Sbjct: 424 ALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRE 483
Query: 525 LQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLC 584
LQDE +L+KI EQEQALQE+G LS+SKLK+EDIKE N+AL+G WLKD EATHC+ C
Sbjct: 484 LQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQC 543
Query: 585 EKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSS 638
EKEFS+S+RKHHCRNCG IFCN CS NEL LPS PKPVRVCDSCH LL+QRCSS
Sbjct: 544 EKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSS 597
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 750 bits (1937), Expect = 0.0
Identities = 374/594 (62%), Positives = 469/594 (78%)
Query: 45 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNK 104
ERANL++M KLSIK L++SALS GR+LD+D+ PLQQFFVVMEHCLKHGLKV+KSF+ NK
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNK 63
Query: 105 TIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQR 164
+ +GPLELVEKL PEA +I SVR+LP LKT +GR RAWL LALMQKK+ADYL+ LI +
Sbjct: 64 SFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNK 123
Query: 165 DLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEED 224
LLSEFYE ALMMEEEG VIVGLLVGLNV+DANLC+KGEDLDSQVGVIDFS+YLK+ +D
Sbjct: 124 HLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQD 183
Query: 225 IGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNII 284
+ + + +I +LDQKNYVEELNR L+ TV L +++D LEK+N+KL EEL+ A + I
Sbjct: 184 LDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRIC 243
Query: 285 KLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDES 344
LQEE QLR +N+LI ++++ +E+TK D + EL+TYK +RQGLDEMY++ +QL++E
Sbjct: 244 SLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 303
Query: 345 QLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQ 404
++R ++E EL +Q+ MK E+E+AMKLLEKD HEKQDTL+ LRQQLEEVKAIN++M+ K Q
Sbjct: 304 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 363
Query: 405 GSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSD 464
+E L++KNE I E KTN++ ++M+Q+E+RLQ +E+A+ AE+ K QE +
Sbjct: 364 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIG 423
Query: 465 SLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLN 524
+LQ Q+SQ +Q LE +LK EKE RQ LQ +LQ EKD S LR E QQ+ LKKE
Sbjct: 424 ALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRE 483
Query: 525 LQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLC 584
LQDE +L+KI EQEQALQE+G LS+SKLK+EDIKE N+AL+G WLKD EATHC+ C
Sbjct: 484 LQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQC 543
Query: 585 EKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSS 638
EKEFS+S+RKHHCRNCG IFCN CS NEL LPS PKPVRVCDSCH LL+QRCSS
Sbjct: 544 EKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSS 597
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 690 bits (1780), Expect = 0.0
Identities = 365/401 (91%), Positives = 367/401 (91%), Gaps = 34/401 (8%)
Query: 36 LATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 95
+ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV
Sbjct: 1 MATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 60
Query: 96 RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMAD 155
RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGL
Sbjct: 61 RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGL---------------------- 98
Query: 156 YLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDF 215
+EFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDF
Sbjct: 99 ------------NEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDF 146
Query: 216 SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEE 275
SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEE
Sbjct: 147 SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEE 206
Query: 276 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE 335
LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE
Sbjct: 207 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE 266
Query: 336 ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI 395
ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI
Sbjct: 267 ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI 326
Query: 396 NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 436
NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ
Sbjct: 327 NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/223 (26%), Positives = 97/223 (43%), Gaps = 35/223 (15%)
Query: 391 EVKAINIEMYQKLQGSED-GLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAE 449
+V I+ MY L+ ED G KE+N IA + ++ N + RQL + E
Sbjct: 140 QVGVIDFSMY--LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLE 197
Query: 450 DEDEKYLQE-CLSKSD------------SLQKQISQKEKQ-----LVQLETDLKIEKEWR 491
+ K ++E ++K++ S K I K +Q V +ET+L+ K R
Sbjct: 198 KSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSR 257
Query: 492 QTLQE-------DLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQ 544
Q L E L+ E + NE +S+K E ++ + L+K HE++ L
Sbjct: 258 QGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHE---IELAMKLLEKDIHEKQDTLI 314
Query: 545 ELGNKLSESK-LKIEDIKEANKALQGLVWLKDKEATHCKLCEK 586
L +L E K + IE ++ + G LK+K +L EK
Sbjct: 315 GLRQQLEEVKAINIEMYQKLQGSEDG---LKEKNEIIARLEEK 354
Score = 42.7 bits (99), Expect = 0.001
Identities = 50/224 (22%), Positives = 104/224 (46%), Gaps = 12/224 (5%)
Query: 340 LRDESQLRQDVEN-ELAVQVSMKHEIELAMKLLEKDI---HEKQDTLIGLRQQLEEVKAI 395
L++E + N ++A + K+ +E + L + H + D+L +L E AI
Sbjct: 150 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 209
Query: 396 NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKY 455
KLQ L+ +N++I ++ ++T +E LQ + ++ + DE Y
Sbjct: 210 AKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKV--DVETELQTYKHSR---QGLDEMY 264
Query: 456 LQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQI 515
+ D Q + + + VQ+ +IE + L++D+ +++D L LR + +++
Sbjct: 265 NEARRQLRDESQLRQDVENELAVQVSMKHEIELAMK-LLEKDIHEKQDTLIGLRQQLEEV 323
Query: 516 ISLKKE-FLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIE 558
++ E + LQ LK+ +E L+E NK++ + ++E
Sbjct: 324 KAINIEMYQKLQGSEDGLKE-KNEIIARLEEKTNKITAAMRQLE 366
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 575 bits (1481), Expect = e-164
Identities = 318/597 (53%), Positives = 424/597 (71%), Gaps = 44/597 (7%)
Query: 43 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 102
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
Query: 103 NKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLII 162
NK+ WGPLELVEKL PEA EI ASV+DLPGLKTP+GR RAWLRLALMQKK+++Y++ LI
Sbjct: 126 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 185
Query: 163 QRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 222
+++LLSEFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 245
Query: 223 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 282
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
Query: 283 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 342
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 306 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 351
Query: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 352 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 411
Query: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSK 462
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQRL+QAE+++ AE ++ + Q+ K
Sbjct: 412 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDK 471
Query: 463 SDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEF 522
+SLQ ++ + +Q QLE +LK EKE R LQ ++ +++ + K +
Sbjct: 472 INSLQLEVEELTRQRNQLELELKQEKERR------LQNDRSIPGRGSQKSESKMDGKHK- 524
Query: 523 LNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
+Q+EN +LKK E +L+ + E ++ L L +K C+
Sbjct: 525 --MQEENVKLKKPLEESH-------------RLQPHPMDEQDQLL-----LSEKPQL-CQ 563
Query: 583 LCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSN 639
LC+++ SL+ K+ C+NC FC+ACS NELPLPSS K RVC+ CH L+++ S++
Sbjct: 564 LCQEDGSLT--KNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYSTS 618
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 487 bits (1254), Expect = e-137
Identities = 252/395 (63%), Positives = 314/395 (79%), Gaps = 14/395 (3%)
Query: 43 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 102
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 126 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 185
Query: 103 NKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLII 162
NK+ WGPLELVEKL PEA EI ASV+DLPGLKTP+GR RAWLRLALMQKK+++Y++ LI
Sbjct: 186 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 245
Query: 163 QRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 222
+++LLSEFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 246 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 305
Query: 223 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 282
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 306 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 365
Query: 283 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 342
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 366 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 411
Query: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 412 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 471
Query: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR 437
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQR
Sbjct: 472 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
Score = 42.4 bits (98), Expect = 0.001
Identities = 50/206 (24%), Positives = 92/206 (44%), Gaps = 35/206 (16%)
Query: 391 EVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKT------NKITAAMRQLEQRLQQAEKA 444
+V I+ MY K S G + +I A L++K + A + L+ ++ EK+
Sbjct: 292 QVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKS 351
Query: 445 QMEAEDEDEKYLQECLSKSDSLQKQISQ-KEKQLVQLETDLKIEKEWRQTLQEDLQKEKD 503
+ +E L ++ +LQ+++ + KE+ LE++ K K+ R + L +
Sbjct: 352 NTKLTEE----LAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALS---E 404
Query: 504 ALSHLRNETQQIISLKKEF---LNLQDENQ----QLKKIYHEQEQAL------------- 543
A HL+ ETQ + ++KE ++++ E + L+K E++ AL
Sbjct: 405 ARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRAL 464
Query: 544 -QELGNKLSESKLKIEDIKEANKALQ 568
EL KL S L ++ E N L+
Sbjct: 465 KHELAFKLQSSDLGVKQKSELNSRLE 490
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 485 bits (1249), Expect = e-137
Identities = 251/394 (63%), Positives = 313/394 (79%), Gaps = 14/394 (3%)
Query: 43 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 102
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
Query: 103 NKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLII 162
NK+ WGPLELVEKL PEA EI ASV+DLPGLKTP+GR RAWLRLALMQKK+++Y++ LI
Sbjct: 126 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 185
Query: 163 QRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 222
+++LLSEFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 245
Query: 223 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 282
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
Query: 283 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 342
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 306 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 351
Query: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 352 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 411
Query: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 436
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQ
Sbjct: 412 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
Score = 42.4 bits (98), Expect = 0.001
Identities = 50/206 (24%), Positives = 92/206 (44%), Gaps = 35/206 (16%)
Query: 391 EVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKT------NKITAAMRQLEQRLQQAEKA 444
+V I+ MY K S G + +I A L++K + A + L+ ++ EK+
Sbjct: 232 QVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKS 291
Query: 445 QMEAEDEDEKYLQECLSKSDSLQKQISQ-KEKQLVQLETDLKIEKEWRQTLQEDLQKEKD 503
+ +E L ++ +LQ+++ + KE+ LE++ K K+ R + L +
Sbjct: 292 NTKLTEE----LAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALS---E 344
Query: 504 ALSHLRNETQQIISLKKEF---LNLQDENQ----QLKKIYHEQEQAL------------- 543
A HL+ ETQ + ++KE ++++ E + L+K E++ AL
Sbjct: 345 ARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRAL 404
Query: 544 -QELGNKLSESKLKIEDIKEANKALQ 568
EL KL S L ++ E N L+
Sbjct: 405 KHELAFKLQSSDLGVKQKSELNSRLE 430
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 130 bits (327), Expect = 4e-30
Identities = 123/449 (27%), Positives = 209/449 (46%), Gaps = 74/449 (16%)
Query: 240 QKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAK-------NNIIKLQEENHQ 292
+K +E L +L V + L++ T+ +ELA K NN K QE Q
Sbjct: 971 KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 293 LRS-----ENKLI-----LMKTQQHLEVTKVDVETE----------LQTYKHSRQGLDEM 332
L+S E++L+ L ++ L + + D+ + +Q K ++ L++
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090
Query: 333 YNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLE----KDIHEKQDTLIGLRQQ 388
+ +QL++ + QD++ E +++ K + KL E K EK+ T +
Sbjct: 1091 SAKKEQQLQERCKALQDIQKEKSLKE--KELVNEKSKLAEIEEIKCRQEKEITKLN---- 1144
Query: 389 LEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEA 448
EE+K+ +E +++ +D + + L+ K + + AA+ Q E+R QQ K Q++
Sbjct: 1145 -EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ-EKRNQQILKDQVKK 1202
Query: 449 EDEDEKYLQECLSKSDSLQKQISQKE--------------KQLVQLETDL-KIEKEWRQT 493
E+E+ K +E + K L +I +KE Q+ L +L ++KEW+ +
Sbjct: 1203 EEEELK--KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS 1260
Query: 494 LQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSES 553
+ + EK LR E I L+ N QDE + L + + E +++L K+ E
Sbjct: 1261 QRRVSELEKQT-DDLRGE---IAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316
Query: 554 KLKIEDIKEA-------NKALQ-------GLVWLKDKEATHCKLCEKEFSLSKRKHHCRN 599
+ K+++ A N++LQ W +D E +C C K FS++ R+HHCR
Sbjct: 1317 QRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQ 1376
Query: 600 CGEIFCNACSDNELPLPSSPKPVRVCDSC 628
CG IFC CS PSS KPVRVCD+C
Sbjct: 1377 CGNIFCAECSAKNALTPSSKKPVRVCDAC 1405
Score = 77.4 bits (189), Expect = 4e-14
Identities = 94/381 (24%), Positives = 170/381 (44%), Gaps = 64/381 (16%)
Query: 237 ILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLI---------------EELAIAKN 281
+L + V ELN QLN + + S++D K+ T+L+ L A+N
Sbjct: 616 VLSLETSVNELNSQLNESKEKV-SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674
Query: 282 NIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE------ 335
+ Q+E +++ ++ + K Q E +E+ L+ YK L++ E
Sbjct: 675 ALQDKQQELNKITTQLDQVTAKLQDKQEHCS-QLESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 336 ---------------ARRQLRDESQLRQDVE---NELAVQVSMKHEIELAMKLLEKDIHE 377
A + L+ + QL D+E EL+ Q+ M+ EI + +L D+ +
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL---DLQK 790
Query: 378 KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR 437
K + L ++Q+L + + E Q L+ + L ++ +I + EE N+I + +L++
Sbjct: 791 KSEALESIKQKLTKQE----EEKQILKQDFETLSQETKI--QHEELNNRIQTTVTELQKV 844
Query: 438 LQQAEKAQMEAEDEDEKYLQECLSK-SDSLQKQISQKEKQ-------LVQLETDLKIEKE 489
+ E E +K LSK SDSL+ S+ EK+ ++ LE K K
Sbjct: 845 KMEKEALMTELSTVKDK-----LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 490 WRQTLQED-LQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGN 548
Q E+ L+++K+ L E + LK E ++Q++ Q + + E+ Q+L
Sbjct: 900 QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQG 959
Query: 549 KLSESKLKIEDIKEANKALQG 569
++E K E K+ +ALQG
Sbjct: 960 NINELKQSSEQKKKQIEALQG 980
Score = 76.3 bits (186), Expect = 8e-14
Identities = 100/425 (23%), Positives = 184/425 (43%), Gaps = 54/425 (12%)
Query: 202 KGEDLDSQVGVIDF-SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQL-------NS 253
K E+L+ Q+ ++ S+ +K ++ ++ Q D + EL++QL +S
Sbjct: 724 KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSS 783
Query: 254 TVSSLHSRVDSLEKSNTKLI---EELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEV 310
T L + ++LE KL EE I K + L +E E + T L+
Sbjct: 784 TRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
Query: 311 TKVDVE---TELQTYKHSRQGLDEMYNEARRQLRDESQ-------------------LRQ 348
K++ E TEL T K + + ++ + E+Q L+
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 349 DVENELAVQVSMKHEIEL---AMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQG 405
+EN L Q +K +E A L+ +++ Q+ LI + L++ N + Q+LQG
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQ----NEKEEQQLQG 959
Query: 406 SEDGLKEKNEI----IARLEEKTNKITAAMRQLEQRLQQ--AEKAQ-MEAEDEDEKYLQE 458
+ + LK+ +E I L+ + +LE +LQQ + AQ + AE E LQ
Sbjct: 960 NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019
Query: 459 CLSKSDSLQKQISQ----KEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQ 514
KS KQ+ +E +L+ DLK +E QEDL ++ + N+ +
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG---NQNKL 1076
Query: 515 IISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLK 574
I LK L+ ++ + ++ E+ +ALQ++ + S + ++ + K ++ + +
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQ 1136
Query: 575 DKEAT 579
+KE T
Sbjct: 1137 EKEIT 1141
Score = 70.5 bits (171), Expect = 5e-12
Identities = 75/357 (21%), Positives = 166/357 (46%), Gaps = 40/357 (11%)
Query: 240 QKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKL 299
Q+N +++ Q + + + RV SLE S +L +L +K + +L + Q++++ +L
Sbjct: 595 QENLHDQVQEQ-KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL---DIQIKAKTEL 650
Query: 300 ILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD---------------ES 344
+L + + D++ L T +++ Q + N+ QL ES
Sbjct: 651 LL-SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 345 QLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQ 404
L++ E L+++ + E+E +K LE D E + + Q L++ + +N ++ +
Sbjct: 710 HLKEYKEKYLSLEQKTE-ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRAT 768
Query: 405 GSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSD 464
L+ + EI++ K + A+ ++Q+L + E+ + + + E QE + +
Sbjct: 769 ELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE 828
Query: 465 SLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLN 524
L +I +L +++ + + T+++ L K D+L + ++E
Sbjct: 829 ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE------------- 875
Query: 525 LQDENQQLKKIYHEQEQALQELGNKLS-ESKLKIEDIKEANKALQGLVWLKDKEATH 580
+ ENQ+ K + E+ +EL ++L + + +++ KE K+L+ K+KEA+H
Sbjct: 876 FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE-----KEKEASH 927
Score = 68.2 bits (165), Expect = 2e-11
Identities = 83/361 (22%), Positives = 165/361 (45%), Gaps = 33/361 (9%)
Query: 216 SMYLKNEEDIGNKER----NVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTK 271
S+ K EE G ++ ++++ A +Q + RQLN+ L R L K +
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNT---DLELRATELSK---Q 773
Query: 272 LIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDE 331
L E I + + LQ+++ L S K L K ++ ++ K D ET Q K + L+
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESI-KQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
Query: 332 MYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKL----LEKDIHEKQDTLIGLRQ 387
+L+ ++ + EL+ ++ ++K EK+ + + ++ L +
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 388 QLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLE---EKTNKITAAMRQLEQRLQQAEKA 444
+E+K +Q E+ LKE+ E+ LE E ++++ + ++++L QA+
Sbjct: 893 TCKELK------HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Query: 445 QMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKE-KD 503
+ E E+ Q+ + L++ QK+KQ+ L+ +LKI + L+ LQ++
Sbjct: 947 LKQNEKEE----QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 504 ALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQAL----QELGNKLSESKLKIED 559
A L E ++I L+ + Q+ +QL+ ++ +E L Q+L + + L ED
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 560 I 560
+
Sbjct: 1063 L 1063
Score = 67.8 bits (164), Expect = 3e-11
Identities = 80/368 (21%), Positives = 155/368 (42%), Gaps = 71/368 (19%)
Query: 235 AAILDQKNYVEELNRQLNST--VSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQ 292
A++ ++K Y EEL ++L + ++ D L ++ ++ L + + + Q EN
Sbjct: 97 ASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSL---EQQLEEAQTENFN 153
Query: 293 LRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVEN 352
++ L K Q L D++++ + R+ ++ +L E+ + QD++
Sbjct: 154 IKQMKDLFEQKAAQ-LATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKT 212
Query: 353 ELA-----------------VQVSMKH----------EIELAMKLLEKDIHEKQDTLIGL 385
EL VQ M + +++ K L+ + T+ L
Sbjct: 213 ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQL 272
Query: 386 RQQL----EEVKAINIEMYQKLQGSEDGLKEKNEIIA-----------RLEEKTNKITAA 430
R +L +EV A+ ++ QKL+ S + L +KN+ + +LEEK N+ + +
Sbjct: 273 RSELAKGPQEV-AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS 331
Query: 431 MRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEW 490
+ ++ L Q + +C LQ ++S E L ++ +L + E
Sbjct: 332 KKNIQATLHQKD--------------LDC----QQLQSRLSASETSLHRIHVELSEKGEA 373
Query: 491 RQTLQEDLQKEKDALSHLRNETQQIISLKKE----FLNLQDENQQLKKIYHEQEQALQEL 546
Q L+E+L + + HL+ E +Q+ ++E L LQ E QL E E+ L E
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 547 GNKLSESK 554
+L E +
Sbjct: 434 HGRLKEQR 441
Score = 67.0 bits (162), Expect = 5e-11
Identities = 83/378 (21%), Positives = 163/378 (43%), Gaps = 71/378 (18%)
Query: 243 YVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILM 302
YV+EL + L S V+ L + N L E L + + KL EE H S +K +
Sbjct: 286 YVQELQK--------LKSSVNELTQKNQTLTENLLKKEQDYTKL-EEKHNEESVSKKNIQ 336
Query: 303 KTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKH 362
T ++ +++ L S L ++ E L ++ + Q ++ EL+ +
Sbjct: 337 ATLHQKDLDCQQLQSRLSA---SETSLHRIHVE----LSEKGEATQKLKEELSEVETKYQ 389
Query: 363 EIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEI------ 416
++ K L++ EK+ + L+ ++ ++ + +E ++L + LKE+ ++
Sbjct: 390 HLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLM 449
Query: 417 ------------IARLE----EKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECL 460
++RLE EK T QL++ QQ ++ Q + K L+E
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK-LREAQ 508
Query: 461 SKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQ---EDL-------QKEKDALSHLRN 510
+ + + +QI K++++ LE L+ KE L+ EDL + E L+ L+
Sbjct: 509 NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE 568
Query: 511 ET----QQIISLKKEFLNLQDENQQLKKIYHEQ------------------EQALQELGN 548
+ +Q+ L ++ N + ++Q ++ H+Q E ++ EL +
Sbjct: 569 KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 549 KLSESKLKIEDIKEANKA 566
+L+ESK K+ + KA
Sbjct: 629 QLNESKEKVSQLDIQIKA 646
Score = 64.3 bits (155), Expect = 3e-10
Identities = 76/369 (20%), Positives = 170/369 (46%), Gaps = 42/369 (11%)
Query: 240 QKNYVEELNRQLNSTVSSLHSRVDSLEK----SNTKLIEELAIAKNNIIKLQEENHQLRS 295
Q+ E+ QL S ++ LHS++ E+ ++ +L E+ ++ KL ++ Q+ +
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE---KLMDKEQQV-A 456
Query: 296 ENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELA 355
+ +L L + ++ L+ KV TELQ H + + E + + + ++ +N+L
Sbjct: 457 DLQLKLSRLEEQLK-EKVTNSTELQ---HQLDKTKQQHQEQQALQQSTTAKLREAQNDLE 512
Query: 356 VQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNE 415
+ + + ++ LE + + ++ + L ++ E+ +Y K+Q E +
Sbjct: 513 QVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED-------LYAKIQAGEG----ETA 561
Query: 416 IIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEK 475
++ +L+EK + + + QL ++L+ ++ +A++ +QE + + Q ++ E
Sbjct: 562 VLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621
Query: 476 QLVQLETDLKIEKEWRQTLQEDLQ---KEKDALSHLRNETQQIISLKKEFLN----LQDE 528
+ +L + L KE + Q D+Q K + LS +T Q L+ LQD+
Sbjct: 622 SVNELNSQLNESKE--KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 529 NQQLKKIYHEQEQALQELGNK----------LSESKLKIEDIKEANKALQGLVWLKDKEA 578
Q+L KI + +Q +L +K L E K K +++ + L+G + + ++
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 579 THCKLCEKE 587
K +++
Sbjct: 740 LEVKASKEQ 748
Score = 57.4 bits (137), Expect = 4e-08
Identities = 62/307 (20%), Positives = 132/307 (42%), Gaps = 28/307 (9%)
Query: 288 EENHQLRSENKLILMKTQQHLEVTKVDVE---TELQTYKHSRQGLDEMYNEARRQLRDES 344
E N L+ ++ +L + Q L+ + + + EL+ QGL + + + D S
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 345 QLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQ 404
Q +E +L + I+ L E+ + + ++ + +E +++ QK+
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 405 GSEDGLKEKNEIIARLEEKT------NKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQE 458
+ L ++ +I L+ + + ++L Q + +E E E EK E
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 459 CLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIIS- 517
C LQ Q + E + QL ++L + ++LQK K +++ L + Q +
Sbjct: 255 C----KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 518 -LKKE--FLNLQDENQQ-------LKKIYHEQEQALQELGNKLSESKLKIE----DIKEA 563
LKKE + L++++ + ++ H+++ Q+L ++LS S+ + ++ E
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 564 NKALQGL 570
+A Q L
Sbjct: 371 GEATQKL 377
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 119 bits (297), Expect = 1e-26
Identities = 110/392 (28%), Positives = 187/392 (47%), Gaps = 64/392 (16%)
Query: 13 ASQVLAWVPDAEGGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLD 72
AS+ L + GG G ++SL+ ++ AVER NL+ + + S+K LI+ S T+D
Sbjct: 2 ASRSLGGLSGIRGGGGGG-GKKSLSARN-AAVERRNLITVCRFSVKTLIDR--SCFETID 57
Query: 73 SDYPPLQQFFVVMEHCLKHGLKVRKSFLSYN--KTIWGPLELVEKLYPEAEEIGASVRDL 130
P F ++E L H LK + ++ Y ++ W + + + ++ S+ ++
Sbjct: 58 DSSPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKV--SQNCICSIENM 115
Query: 131 PGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLV 190
+ + + RAW+R+ALM+K +++Y+ + FYE A+++ EE ++ G+L+
Sbjct: 116 ENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLL 175
Query: 191 GLNVIDANLCVKGEDLD-SQVGVIDFSMYLK--------------------------NEE 223
GLN ID + C+KGE LD S VID++ YLK E
Sbjct: 176 GLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPE 235
Query: 224 DIG-----------NKERNV--QIAAILDQKNYVEELNR----QLNSTVSSLHSRVDSLE 266
++G NK + V + L+QK Y+EEL R QL+ +VS + +E
Sbjct: 236 NVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIE 295
Query: 267 KSNTKLIEELAIAKNNIIKLQEE-----NHQLRSENKLILMKTQQ-----HLEVTKVDVE 316
S+ E + I++LQ++ N+ LRS +L T Q L+V V ++
Sbjct: 296 DSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALD 355
Query: 317 TELQTYKHSRQGLDEMYNEARRQLRDESQLRQ 348
T L KH++Q ++ Y ++ QL E L Q
Sbjct: 356 TLLYR-KHNKQWYEKSY-QSLDQLSAEVSLSQ 385
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 112 bits (279), Expect = 1e-24
Identities = 85/336 (25%), Positives = 167/336 (49%), Gaps = 19/336 (5%)
Query: 13 ASQVLAWVPDAEGGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLD 72
AS+ L + GG G ++SL+ ++ AVER NL+ + + S+K LI+ S T+D
Sbjct: 2 ASRSLGGLSGIRGGGGGG-GKKSLSARN-AAVERRNLITVCRFSVKTLIDR--SCFETID 57
Query: 73 SDYPPLQQFFVVMEHCLKHGLKVRKSFLSYN--KTIWGPLELVEKLYPEAEEIGASVRDL 130
P F ++E L H LK + ++ Y ++ W + + + ++ S+ ++
Sbjct: 58 DSSPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKV--SQNCICSIENM 115
Query: 131 PGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLV 190
+ + + RAW+R+ALM+K +++Y+ + FYE A+++ EE ++ G+L+
Sbjct: 116 ENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLL 175
Query: 191 GLNVIDANLCVKGEDLD-SQVGVIDFSMYLK---NEEDIGNKERNVQ-IAAILDQKNYVE 245
GLN ID + C+KGE LD S VID++ YLK + + I + E ++ + + + + E
Sbjct: 176 GLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPE 235
Query: 246 ELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQ 305
+ +S ++ +++ +E+ + + + + + S+NK++L + +
Sbjct: 236 NVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIE 295
Query: 306 QHLEVTKVDVE------TELQTYKHSRQGLDEMYNE 335
K++ E ELQ S Q LD++ E
Sbjct: 296 DSDLAHKLEKEQLEYIIVELQDQLKSYQSLDQLSAE 331
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 108 bits (270), Expect = 2e-23
Identities = 110/409 (26%), Positives = 187/409 (45%), Gaps = 81/409 (19%)
Query: 13 ASQVLAWVPDAEGGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLD 72
AS+ L + GG G ++SL+ ++ AVER NL+ + + S+K LI+ S T+D
Sbjct: 2 ASRSLGGLSGIRGGGGGG-GKKSLSARN-AAVERRNLITVCRFSVKTLIDR--SCFETID 57
Query: 73 SDYPPLQQFFVVMEHCLKHGLKV-----------------RKSFLSYN--KTIWGPLELV 113
P F ++E L H LK + ++ Y ++ W + +
Sbjct: 58 DSSPEFNNFAAILEQILSHRLKEISQSCRWLAHLQIPLQGQVTWFGYESPRSFWDYIRVA 117
Query: 114 EKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEY 173
+ ++ S+ ++ + + + RAW+R+ALM+K +++Y+ + FYE
Sbjct: 118 CRKV--SQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYED 175
Query: 174 HALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLD-SQVGVIDFSMYLK------------ 220
A+++ EE ++ G+L+GLN ID + C+KGE LD S VID++ YLK
Sbjct: 176 GAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDE 235
Query: 221 --------------NEEDIG-----------NKERNV--QIAAILDQKNYVEELNR---- 249
E++G NK + V + L+QK Y+EEL R
Sbjct: 236 EELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLREN 295
Query: 250 QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEE-----NHQLRSENKLILMKT 304
QL+ +VS + +E S+ E + I++LQ++ N+ LRS +L T
Sbjct: 296 QLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLT 355
Query: 305 QQ-----HLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQ 348
Q L+V V ++T L KH++Q ++ Y ++ QL E L Q
Sbjct: 356 NQWPSPGALDVNAVALDTLLYR-KHNKQWYEKSY-QSLDQLSAEVSLSQ 402
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 102 bits (254), Expect = 1e-21
Identities = 72/271 (26%), Positives = 134/271 (49%), Gaps = 17/271 (6%)
Query: 37 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 96
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKGP 76
Query: 97 KSFLSYN--KTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMA 154
S+ S + + W + L P +S+ ++ + T + RAW+R+ALM+K+M+
Sbjct: 77 VSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRMS 134
Query: 155 DYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVG-VI 213
+Y+ + FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD + VI
Sbjct: 135 EYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVI 194
Query: 214 DFSMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEK--- 267
D++ YLK + + + ++E + + N E L + S +S+ +E+
Sbjct: 195 DYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFR 254
Query: 268 ---SNTKLIEELAIAKNNIIK-LQEENHQLR 294
+ +EEL + + +K L+ EN +L+
Sbjct: 255 IVYAQKGYLEELVRLRESQLKDLEAENRRLQ 285
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 97.4 bits (241), Expect = 3e-20
Identities = 72/276 (26%), Positives = 134/276 (48%), Gaps = 22/276 (7%)
Query: 37 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 96
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKAC 76
Query: 97 K-----SFLSYN--KTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALM 149
S+ S + + W + L P +S+ ++ + T + RAW+R+ALM
Sbjct: 77 APAGPVSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALM 134
Query: 150 QKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQ 209
+K+M++Y+ + FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD +
Sbjct: 135 EKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGK 194
Query: 210 VG-VIDFSMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL 265
VID++ YLK + + + ++E + + N E L + S +S+ +
Sbjct: 195 TPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKM 254
Query: 266 EK------SNTKLIEELAIAKNNIIK-LQEENHQLR 294
E+ + +EEL + + +K L+ EN +L+
Sbjct: 255 EQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQ 290
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 97.4 bits (241), Expect = 3e-20
Identities = 72/276 (26%), Positives = 134/276 (48%), Gaps = 22/276 (7%)
Query: 37 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 96
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKAC 76
Query: 97 K-----SFLSYN--KTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALM 149
S+ S + + W + L P +S+ ++ + T + RAW+R+ALM
Sbjct: 77 APAGPVSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALM 134
Query: 150 QKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQ 209
+K+M++Y+ + FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD +
Sbjct: 135 EKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGK 194
Query: 210 VG-VIDFSMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL 265
VID++ YLK + + + ++E + + N E L + S +S+ +
Sbjct: 195 TPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKM 254
Query: 266 EK------SNTKLIEELAIAKNNIIK-LQEENHQLR 294
E+ + +EEL + + +K L+ EN +L+
Sbjct: 255 EQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQ 290
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 94.7 bits (234), Expect = 2e-19
Identities = 92/367 (25%), Positives = 172/367 (46%), Gaps = 31/367 (8%)
Query: 227 NKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKL 286
N ER ++I +E+ N LN TVSSL R ++ K IE+ +N I+
Sbjct: 548 NSERQIKI---------LEQENEHLNQTVSSLRQRSQISAEARVKDIEK----ENKIL-- 592
Query: 287 QEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 346
H+ E L K +E K ++ EL+ YK + +E+ NE L E++L
Sbjct: 593 ----HESIKETSSKLSK----IEFEKRQIKKELEHYKEKGERAEELENELHH-LEKENEL 643
Query: 347 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQ---QLEEVKAINIEMYQK- 402
Q L + +E LE++ + + TL + QLE ++ N ++ ++
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 403 --LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECL 460
L+ + + LK + +A+L+ + ++ + QL++ L+ KA + + E Q
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL-KASFKKTERLEVSYQGLD 762
Query: 461 SKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKK 520
++ LQK + K++ QLE++L+ + QTLQ++L++ K + L ++ SL++
Sbjct: 763 IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 521 EFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATH 580
E L+ + +QL+K Q + L E+ +KI ++++ NK L + + +
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR 882
Query: 581 CKLCEKE 587
K EKE
Sbjct: 883 LKELEKE 889
Score = 79.0 bits (193), Expect = 1e-14
Identities = 88/369 (23%), Positives = 179/369 (48%), Gaps = 46/369 (12%)
Query: 202 KGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHS- 260
+ E+L++++ ++ L ++ K +I A+ + + +E NR+L T+ S +
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 261 --RVDSLEKSNTKL----------IEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHL 308
+++SLEK N++L +E L A + +LQ EN +L SE + + ++ L
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL----KKGL 741
Query: 309 EVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAM 368
E+ K + + + + S QGLD ++ L + ++ Q +E+EL ++E+
Sbjct: 742 ELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL-------QDLEMEN 793
Query: 369 KLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKIT 428
+ L+K++ E + + L Q +E K++ E Q L+ + L+++N+ RL ++
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQ-LEKDKKQLEKENK---RLRQQAEIKD 849
Query: 429 AAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEK 488
+ + ++ EK E Y + C+ K++ ++ K+LV+ T I+
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL-----KELEKENKELVKRAT---IDI 901
Query: 489 EWRQTLQEDLQKEKDALSHLRNETQQII-SLKKEFLNLQDENQQLKKIYHEQEQALQELG 547
+ TL+EDL EK + N+ +++ L+K LN + ++ H+ EQ+ +
Sbjct: 902 KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE-------RLLHD-EQSTDDSR 953
Query: 548 NKLSESKLK 556
KL ESKL+
Sbjct: 954 YKLLESKLE 962
Score = 71.6 bits (174), Expect = 2e-12
Identities = 86/353 (24%), Positives = 163/353 (46%), Gaps = 31/353 (8%)
Query: 219 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 278
LK ++ + ERN A + +K ++ +QL + ++L +++ +L++ L E+
Sbjct: 1042 LKVKDRLIEVERNN--ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1099
Query: 279 AKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARR 338
+ KLQ EN L S++ LM L + + +E E ++ R+ L +Y+ +
Sbjct: 1100 LQTQNAKLQVENSTLNSQS-TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1158
Query: 339 QLRDESQLRQDVENELAVQVSMKHEIELAMKLLE---KDIHEKQDTLIGLRQQLEEV-KA 394
L + +E +S ++ A K LE +D+ ++ + L+ + QLE++ K
Sbjct: 1159 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM 1218
Query: 395 INIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEK 454
+ +E + L L+ KN E K K+ +L Q K + E D K
Sbjct: 1219 LKVEQEKML------LENKNHETVAAEYK--KLCGENDRLNHTYSQLLK-ETEVLQTDHK 1269
Query: 455 YLQECLSKS----DSLQKQISQKEKQLVQLE---TDLKIEKEWRQTLQEDLQKEKDALSH 507
L+ L+ S L+ + S+ ++Q QL+ T L + E L+ +L++E
Sbjct: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN----- 1324
Query: 508 LRNETQQIISLKKEFLNLQDENQQLKKIYH-EQEQALQELGNKLSESKLKIED 559
R+ QI +L + L ++N + K ++H EQ Q + +L N+L K K+E+
Sbjct: 1325 -RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL-NELRRQKEKLEE 1375
Score = 69.3 bits (168), Expect = 1e-11
Identities = 93/436 (21%), Positives = 196/436 (44%), Gaps = 86/436 (19%)
Query: 227 NKERNVQIAAILDQKNYVEELNRQL-------NSTVSSLHSRVDSLEKSNTKLIEELAIA 279
NK + + + K +E+ N++L ++T+ + ++ +LEK N L +E+ I
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 280 KNNIIKLQEENHQLRSENKLILMKT---------------QQHLEVTKVDVETELQTYKH 324
K + ++L+E L ENK ++ + + L+ +++ + E T++
Sbjct: 877 KESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL 932
Query: 325 SRQGLDEMYNEARRQLRDESQ---LRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDT 381
+ GL++ Q D+S+ L +E+ L + +K E + LE + E +
Sbjct: 933 EKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEE---KIAALEARLEESTNY 989
Query: 382 LIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIA---RLEEKTNKITAAMRQLEQRL 438
LRQ+L+ VK N E ++ Q E ++ I + E ++ + T + +++ RL
Sbjct: 990 NQQLRQELKTVKK-NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048
Query: 439 QQAEK--AQMEAEDEDEK-YLQECLSKSDSLQKQISQKEKQLVQLE---TDLKIEKEWRQ 492
+ E+ A ++AE + K L++ +++++LQ QI ++Q V L+ T L+ + Q
Sbjct: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
Query: 493 TLQEDLQKEKDAL-----------SHLRNETQQIISLKKEFLNLQD---ENQQLKKIYHE 538
L + +L S L NE + +I +++ +L D ++ + ++ HE
Sbjct: 1109 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHE 1168
Query: 539 QEQA-------------------------LQELGNKLSESKLKIEDIKEANKALQGLVWL 573
++ + L++ N+L + K ++ED+++ K Q + L
Sbjct: 1169 RQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL 1228
Query: 574 KDKE-----ATHCKLC 584
++K A + KLC
Sbjct: 1229 ENKNHETVAAEYKKLC 1244
Score = 64.3 bits (155), Expect = 3e-10
Identities = 91/366 (24%), Positives = 171/366 (46%), Gaps = 29/366 (7%)
Query: 228 KERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL----EKSNTKLIEELAIAKNNI 283
K ++++ +D+K E + + ++ S +SL E EL+ A
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQK- 448
Query: 284 IKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDE 343
L E ++L S L L Q L T VE EL+T S +G + ++ +
Sbjct: 449 -SLGHEVNELTSSRLLKLEMENQSLTKT---VE-ELRTTVDSVEGNASKILKMEKENQRL 503
Query: 344 SQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKL 403
S+ + +ENE+ + + K L K+ + + T+ LR+ E I + + L
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 404 QGSEDGLKEKNEIIARLE----EKTNKIT-AAMRQLEQRLQQAEKAQMEAEDEDEKYLQE 458
+ L+++++I A EK NKI ++++ +L + E + + + E E Y +E
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY-KE 622
Query: 459 CLSKSDSLQKQIS--QKEKQLVQLE-TDLKIEKEWRQTLQE---DLQKE----KDALSHL 508
+++ L+ ++ +KE +L+Q + T+LKI E + L++ +L++E K L
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 509 RNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQ 568
+N T Q+ SL+KE L +EN +L++ + A ++ E+K ++E KE K +
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK-ELESEKEQLK--K 739
Query: 569 GLVWLK 574
GL LK
Sbjct: 740 GLELLK 745
Score = 45.1 bits (105), Expect = 2e-04
Identities = 39/171 (22%), Positives = 82/171 (47%), Gaps = 17/171 (9%)
Query: 402 KLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR----LQQAEKAQMEAEDEDEKYLQ 457
K++ L+EK E + +++ ++ +++L+Q L A A+M ++ D L+
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA--LR 316
Query: 458 ECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIIS 517
E + D L+ ++S+ +++L D++ K + L+ED Q + + L ++ + +
Sbjct: 317 EKAVRVDKLESEVSRYKERL----HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 518 LKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQ 568
+ L+ EN QLK H+ E + + KIE++ E N L+
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEM-------ERDMDRKKIEELMEENMTLE 416
Score = 35.8 bits (81), Expect = 0.12
Identities = 66/353 (18%), Positives = 146/353 (41%), Gaps = 33/353 (9%)
Query: 251 LNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN--IIKLQEENHQLRSENKLILMKTQQHL 308
LN + ++ +++S ++ N K+ + ++ +N I+ Q + + + +LI+M L
Sbjct: 48 LNQVMLQINPKLES-QRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVL 106
Query: 309 EVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAM 368
+ K S QG +E+ L Q ++ E +Q + + + A+
Sbjct: 107 IIGK---------NPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQ-GLDFDTKAAV 156
Query: 369 KLLEKDIHEKQDTLIGLR------QQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEE 422
+++ Q+ + L+ E+++ + M L+ D E +E I L E
Sbjct: 157 AAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE 216
Query: 423 KTNKI---TAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQ 479
+ + + A + + E+ L + +K L++++ +K +QL+
Sbjct: 217 ERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD 276
Query: 480 LETDLK-IEKEWRQTLQEDLQKEKDA---------LSHLRNETQQIISLKKEFLNLQDEN 529
+ +L+ +E E ++ QE++ DA L LR + ++ L+ E ++
Sbjct: 277 CKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL 336
Query: 530 QQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
++ Y + + L+E L E+K +ED E +A + +KE K
Sbjct: 337 HDIE-FYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 94.7 bits (234), Expect = 2e-19
Identities = 92/367 (25%), Positives = 172/367 (46%), Gaps = 31/367 (8%)
Query: 227 NKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKL 286
N ER ++I +E+ N LN TVSSL R ++ K IE+ +N I+
Sbjct: 548 NSERQIKI---------LEQENEHLNQTVSSLRQRSQISAEARVKDIEK----ENKIL-- 592
Query: 287 QEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 346
H+ E L K +E K ++ EL+ YK + +E+ NE L E++L
Sbjct: 593 ----HESIKETSSKLSK----IEFEKRQIKKELEHYKEKGERAEELENEL-HHLEKENEL 643
Query: 347 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQ---QLEEVKAINIEMYQ-- 401
Q L + +E LE++ + + TL + QLE ++ N ++ +
Sbjct: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 402 -KLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECL 460
+L+ + + LK + +A+L+ + ++ + QL++ L+ KA + + E Q
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL-KASFKKTERLEVSYQGLD 762
Query: 461 SKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKK 520
++ LQK + K++ QLE++L+ + QTLQ++L++ K + L ++ SL++
Sbjct: 763 IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 521 EFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATH 580
E L+ + +QL+K Q + L E+ +KI ++++ NK L + + +
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR 882
Query: 581 CKLCEKE 587
K EKE
Sbjct: 883 LKELEKE 889
Score = 71.6 bits (174), Expect = 2e-12
Identities = 86/353 (24%), Positives = 163/353 (46%), Gaps = 31/353 (8%)
Query: 219 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 278
LK ++ + ERN A + +K ++ +QL + ++L +++ +L++ L E+
Sbjct: 1041 LKVKDRLIEVERNN--ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1098
Query: 279 AKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARR 338
+ KLQ EN L S++ LM L + + +E E ++ R+ L +Y+ +
Sbjct: 1099 LQTQNAKLQVENSTLNSQS-TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1157
Query: 339 QLRDESQLRQDVENELAVQVSMKHEIELAMKLLE---KDIHEKQDTLIGLRQQLEEV-KA 394
L + +E +S ++ A K LE +D+ ++ + L+ + QLE++ K
Sbjct: 1158 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM 1217
Query: 395 INIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEK 454
+ +E + L L+ KN E K K+ +L Q K + E D K
Sbjct: 1218 LKVEQEKML------LENKNHETVAAEYK--KLCGENDRLNHTYSQLLK-ETEVLQTDHK 1268
Query: 455 YLQECLSKS----DSLQKQISQKEKQLVQLE---TDLKIEKEWRQTLQEDLQKEKDALSH 507
L+ L+ S L+ + S+ ++Q QL+ T L + E L+ +L++E
Sbjct: 1269 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN----- 1323
Query: 508 LRNETQQIISLKKEFLNLQDENQQLKKIYH-EQEQALQELGNKLSESKLKIED 559
R+ QI +L + L ++N + K ++H EQ Q + +L N+L K K+E+
Sbjct: 1324 -RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL-NELRRQKEKLEE 1374
Score = 68.2 bits (165), Expect = 2e-11
Identities = 96/463 (20%), Positives = 190/463 (41%), Gaps = 93/463 (20%)
Query: 202 KGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHS- 260
+ E+L++++ ++ L ++ K +I A+ + + +E NR+L T+ S +
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 261 --RVDSLEKSNTKL----------IEELAIAKNNIIKLQEENHQLRSENKLIL------- 301
+++SLEK N++L +E L A + +LQ EN +L SE + +
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745
Query: 302 --MKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD---ESQLRQDVENELAV 356
K + LEV+ ++ E Q + + + ++ + +L+D E+Q Q EL +
Sbjct: 746 ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKI 805
Query: 357 QVSMKHEIELAMKLLE-------KDIHEKQDTLIGLRQQLE---------EVKAINIEMY 400
++E K LE KD + + LRQQ E VK N+E
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 401 QKLQGSEDGL------------KEKNEIIARL---------------------EEKTNKI 427
K E G+ KE E++ R ++ N +
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 428 TAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIE 487
+LE+ E+ + + D++Y +L+K + KE+++ LE L+
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 488 KEWRQTLQEDL---QKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQ 544
+ Q L+++L +K +AL ++E + + S + + ++ E+ Q
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQS-----------SPPISGEDNKWERESQ 1034
Query: 545 ELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKE 587
E +L + K ++ +++ N LQ +K+A +L + E
Sbjct: 1035 ETTRELLKVKDRLIEVERNNATLQA-----EKQALKTQLKQLE 1072
Score = 64.3 bits (155), Expect = 3e-10
Identities = 91/366 (24%), Positives = 171/366 (46%), Gaps = 29/366 (7%)
Query: 228 KERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL----EKSNTKLIEELAIAKNNI 283
K ++++ +D+K E + + ++ S +SL E EL+ A
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQK- 448
Query: 284 IKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDE 343
L E ++L S L L Q L T VE EL+T S +G + ++ +
Sbjct: 449 -SLGHEVNELTSSRLLKLEMENQSLTKT---VE-ELRTTVDSVEGNASKILKMEKENQRL 503
Query: 344 SQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKL 403
S+ + +ENE+ + + K L K+ + + T+ LR+ E I + + L
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 404 QGSEDGLKEKNEIIARLE----EKTNKIT-AAMRQLEQRLQQAEKAQMEAEDEDEKYLQE 458
+ L+++++I A EK NKI ++++ +L + E + + + E E Y +E
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY-KE 622
Query: 459 CLSKSDSLQKQIS--QKEKQLVQLE-TDLKIEKEWRQTLQE---DLQKE----KDALSHL 508
+++ L+ ++ +KE +L+Q + T+LKI E + L++ +L++E K L
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 509 RNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQ 568
+N T Q+ SL+KE L +EN +L++ + A ++ E+K ++E KE K +
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK-ELESEKEQLK--K 739
Query: 569 GLVWLK 574
GL LK
Sbjct: 740 GLELLK 745
Score = 45.1 bits (105), Expect = 2e-04
Identities = 39/171 (22%), Positives = 82/171 (47%), Gaps = 17/171 (9%)
Query: 402 KLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR----LQQAEKAQMEAEDEDEKYLQ 457
K++ L+EK E + +++ ++ +++L+Q L A A+M ++ D L+
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA--LR 316
Query: 458 ECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIIS 517
E + D L+ ++S+ +++L D++ K + L+ED Q + + L ++ + +
Sbjct: 317 EKAVRVDKLESEVSRYKERL----HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 518 LKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQ 568
+ L+ EN QLK H+ E + + KIE++ E N L+
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEM-------ERDMDRKKIEELMEENMTLE 416
Score = 41.6 bits (96), Expect = 0.002
Identities = 77/363 (21%), Positives = 151/363 (41%), Gaps = 48/363 (13%)
Query: 258 LHSRVDSLEKSNTKLIEE-LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVE 316
L S+++S K + ++ EE +A + + + N QLR E K + K + D E
Sbjct: 956 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV--KKNYEALKQRQDEE 1013
Query: 317 TELQTYKHSRQGLDEMYNEARRQLRDESQLRQ---DVENELAVQVSMKHEIELAMKLLEK 373
+Q+ ++ E++ R+ +++ +VE A + K ++ +K LE
Sbjct: 1014 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1073
Query: 374 DIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQ 433
+ Q ++ L++Q ++ E LQ L+ +N + ++ T+ M Q
Sbjct: 1074 QNNNLQAQILALQRQTVSLQ----EQNTTLQTQNAKLQVENSTL------NSQSTSLMNQ 1123
Query: 434 LEQRLQQAEKAQMEAED-----EDEKYLQECLSKSD-----------SLQKQISQKEKQL 477
Q L Q + E E ED K L + L K S + + K L
Sbjct: 1124 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1183
Query: 478 VQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQ-----QL 532
+L++E + L K+K L L ++++ +++E + L+++N +
Sbjct: 1184 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL----EKMLKVEQEKMLLENKNHETVAAEY 1239
Query: 533 KKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSK 592
KK+ E ++ L + S+ + E ++ +K L+ L+ E T E EFS K
Sbjct: 1240 KKLCGENDR----LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR---LEAEFSKLK 1292
Query: 593 RKH 595
++
Sbjct: 1293 EQY 1295
Score = 35.8 bits (81), Expect = 0.12
Identities = 66/353 (18%), Positives = 146/353 (41%), Gaps = 33/353 (9%)
Query: 251 LNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN--IIKLQEENHQLRSENKLILMKTQQHL 308
LN + ++ +++S ++ N K+ + ++ +N I+ Q + + + +LI+M L
Sbjct: 48 LNQVMLQINPKLES-QRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVL 106
Query: 309 EVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAM 368
+ K S QG +E+ L Q ++ E +Q + + + A+
Sbjct: 107 IIGK---------NPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQ-GLDFDTKAAV 156
Query: 369 KLLEKDIHEKQDTLIGLR------QQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEE 422
+++ Q+ + L+ E+++ + M L+ D E +E I L E
Sbjct: 157 AAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE 216
Query: 423 KTNKI---TAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQ 479
+ + + A + + E+ L + +K L++++ +K +QL+
Sbjct: 217 ERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD 276
Query: 480 LETDLK-IEKEWRQTLQEDLQKEKDA---------LSHLRNETQQIISLKKEFLNLQDEN 529
+ +L+ +E E ++ QE++ DA L LR + ++ L+ E ++
Sbjct: 277 CKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL 336
Query: 530 QQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
++ Y + + L+E L E+K +ED E +A + +KE K
Sbjct: 337 HDIE-FYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 89.4 bits (220), Expect = 1e-17
Identities = 102/493 (20%), Positives = 197/493 (39%), Gaps = 79/493 (16%)
Query: 209 QVGVIDFSMYLKNEEDIG----NKERNVQIAAILDQ------KNYVEELNRQLNSTVSSL 258
Q +I+ K ++ +G N+ R + L Q + V+ L Q+ + +
Sbjct: 740 QTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKM 799
Query: 259 HSRVDSLEKSNTKLIEELAIAKNN---IIKLQEENHQLRSENKLILMKTQQHLEVTKVDV 315
+ +D +K ++L A+ + + + +L+E+N L + L++ + + +
Sbjct: 800 RAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEER 859
Query: 316 ETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDI 375
E Q + + L E ++A+ + +++ +L + E+ + + L +
Sbjct: 860 ADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEK 919
Query: 376 HEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAA----- 430
++ L Q+L++ K + L+ GL+++ E L+EK AA
Sbjct: 920 ERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKE---SLQEKLKAAKAAAGSLP 976
Query: 431 -----MRQLEQRLQQAEKA----------QMEAEDED-EKYLQECLSKSDSLQKQISQKE 474
+ Q EQR Q ++A Q+ AE D + L+ + SL+ Q+ ++
Sbjct: 977 GLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQG 1036
Query: 475 KQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKK 534
+QL E ++ K + + E L + HL ++ KE L+++ ++ +K
Sbjct: 1037 RQLQAAEEAVEKLKATQADMGEKLSCTSN---HLAECQAAMLRKDKEGAALREDLERTQK 1093
Query: 535 IYHEQEQALQELGNKLSESKLK-----------IEDIKEANKALQGLV------------ 571
+ +QE NKL + ++D+ K L+ +
Sbjct: 1094 ELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQ 1153
Query: 572 ----------------WLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPL 615
WL D EA HC C++EFS R+HHCR CG IFC C +N +
Sbjct: 1154 KSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYVLS 1213
Query: 616 PSSPKPVRVCDSC 628
K R C +C
Sbjct: 1214 KHGGKKERCCRAC 1226
Score = 83.2 bits (204), Expect = 7e-16
Identities = 118/541 (21%), Positives = 227/541 (41%), Gaps = 74/541 (13%)
Query: 68 GRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASV 127
G + D L +F +E+ L+ K + + L K W A + V
Sbjct: 32 GEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFV 91
Query: 128 RDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEE-GAVIV 186
+ + L+T LG+ RA++R +L+ +++AD L+ + + S++Y + ++ + + IV
Sbjct: 92 KSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIV 151
Query: 187 GLLVGLNVIDANLCVKGEDLDSQVGVID-------------------------FSMYLKN 221
G L L + +L +G DLD+ S YL+
Sbjct: 152 GQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQT 211
Query: 222 EEDIGNKERNVQI--AAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIA 279
+E + N + N + A+ EL+ QL L R+ L++ N +L ++
Sbjct: 212 QEMVSNFDLNSPLNNEALEGFDEMRLELD-QLEVREKQLRERMQQLDRENQELRAAVSQQ 270
Query: 280 KNNIIKLQEENHQLRSEN---KLILMKTQQHLEVTKVDVET--ELQTYKHSRQGL----- 329
+ +E +N ++ + Q+ EVT+ T ELQT QGL
Sbjct: 271 GEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQT---CLQGLELGAA 327
Query: 330 --DEMYNEARRQLRDESQ-LRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLR 386
+E Y+ A R+L Q L Q++E + K++ + +K DT +
Sbjct: 328 EKEEDYHTALRRLESMLQPLAQELE-ATRDSLDKKNQHLASFPGWLAMAQQKADTASDTK 386
Query: 387 QQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQM 446
+ E + + + Q++Q E E + LE + K+ RQ +L+Q K ++
Sbjct: 387 GRQEPIPS---DAAQEMQ-------ELGEKLQALERERTKVEEVNRQQSAQLEQLVK-EL 435
Query: 447 EAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALS 506
+ +++ L+ + + LQ+++S K ++ QL WR+ LQE L+
Sbjct: 436 QLKEDARASLERLVKEMAPLQEELSGKGQEADQL---------WRR-LQE-------LLA 478
Query: 507 HLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKA 566
H + +++ L++E Q+E + L++ + LQ L +L++ + D++E K
Sbjct: 479 HTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQ 538
Query: 567 L 567
L
Sbjct: 539 L 539
Score = 52.8 bits (125), Expect = 1e-06
Identities = 87/475 (18%), Positives = 180/475 (37%), Gaps = 95/475 (20%)
Query: 204 EDLDSQVGVIDFSMYLKNEEDIGNK--ERNVQIAAILDQKNYVEELNRQLNSTVSSLHSR 261
E+ + + V L+ E + G E NV++ ++ + E+ + +TV L +
Sbjct: 259 ENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTC 318
Query: 262 VDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTK---VDVETE 318
+ LE + E+ A + + + Q + L K QHL + +
Sbjct: 319 LQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQK 378
Query: 319 LQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEK 378
T ++ + + ++A +++++ + Q +E E + + ++ L K++ K
Sbjct: 379 ADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLK 438
Query: 379 QDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIAR------------------- 419
+D L + ++E+ + E+ K Q ++ + E++A
Sbjct: 439 EDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQ 498
Query: 420 -----LEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQIS--- 471
LE++ +T ++ LE +L Q + + E++ ++ +Q+ D L +Q+
Sbjct: 499 EEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQD----KDHLSQQVGMLE 554
Query: 472 --------------QKEKQLVQLETDL-----KIEKEWRQTLQEDLQKEKDALSHLRNET 512
+K + LV + + L K E+E R + L K E
Sbjct: 555 RLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEEL 614
Query: 513 QQII-SLKKEFLNLQDENQQLK----------KIYHEQEQALQ--------------ELG 547
+Q L+KE N+ NQ L+ + ++E A+Q LG
Sbjct: 615 RQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLG 674
Query: 548 NKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNCGE 602
+++ S L + KEA KA ++ EKE L ++ C+ E
Sbjct: 675 DQMEASLLAVRKAKEAMKA---------------QMAEKEAILQSKEGECQQLRE 714
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 88.2 bits (217), Expect = 2e-17
Identities = 84/383 (21%), Positives = 190/383 (49%), Gaps = 30/383 (7%)
Query: 234 IAAILDQKN----YVEELNRQLNSTVSSLHSRV---DSLEKSNTKLIEELAIAKNNIIKL 286
++A+ QK Y+EEL ++ ++ L+ + L++ N KL E+L + ++ ++
Sbjct: 242 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 301
Query: 287 QEENHQLRSE-NKLILMKTQQHLEVTKVDVETELQTYKHSRQGL---DEMYNEARRQLRD 342
Q +L+ + + L+ QQ L+ + ELQ+ Q +E++N +Q ++
Sbjct: 302 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ-QE 360
Query: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
E RQ+ + + E E ++ E+ I E+++ + +++ + + E +K
Sbjct: 361 EKMWRQEEKIQ---------EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 411
Query: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEK-AQMEAEDEDEKYLQECLS 461
++ E+ + EK E + R EE + +R+LE+++ + EK + E + ++E+ ++E
Sbjct: 412 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 471
Query: 462 KSDSLQKQISQKEKQLVQLE-TDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKK 520
+ + K Q+EK Q E + EK WRQ +E + +++ + + Q+ + ++
Sbjct: 472 RQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ--EEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 521 EFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATH 580
E + Q+E + K+ HEQE+ +++ K+ + K+ D +E + + VW +++
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEE---- 585
Query: 581 CKLCEKEFSLSKRKHHCRNCGEI 603
K+ E+E + +++ R E+
Sbjct: 586 -KIREQEEKIREQEEKIREQEEM 607
Score = 67.0 bits (162), Expect = 5e-11
Identities = 73/357 (20%), Positives = 177/357 (49%), Gaps = 37/357 (10%)
Query: 222 EEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLI--EELAIA 279
E ++ N+ Q + Q+ ++E ++ + + + + + K+ EE+
Sbjct: 348 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 407
Query: 280 KNNIIKLQEE-----NHQLRSENKLILMKTQQHLEVT-KVDVETELQTYKHSRQGLDEMY 333
K ++ QEE ++R + +++ K ++ E+ K+ + +++ + RQ +++
Sbjct: 408 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 467
Query: 334 NEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVK 393
+ +RQ ++ RQ E ++ Q E E M E+ IHE++ ++Q +E
Sbjct: 468 EQEKRQEQEAKMWRQ--EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQE-- 523
Query: 394 AINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDE 453
EM+++ E+ ++E+ EI R +EK ++ +R+ E+++ + E+ + D++E
Sbjct: 524 ----EMWRQ----EEKIREQEEIW-RQKEKIHEQEEKIRKQEEKMWRQEE---KMHDQEE 571
Query: 454 KYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQ 513
K ++E K +++I ++E+++ + E ++ ++E Q +E + ++++ + + Q
Sbjct: 572 K-IREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ 630
Query: 514 QIISLKKEFLNLQDEN--QQLKKI------YHEQEQALQELGNKLSESKLKIEDIKE 562
+ ++E + Q+E +Q KKI EQE+ +QE K+ E + K+ + +E
Sbjct: 631 E----QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 683
Score = 64.7 bits (156), Expect = 3e-10
Identities = 57/288 (19%), Positives = 140/288 (48%), Gaps = 27/288 (9%)
Query: 273 IEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEM 332
I EL + K++E+ + + E K+ + +Q E E +++ + + +E
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK 499
Query: 333 YNEARRQLRDESQLRQDV----ENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQ 388
++ ++ ++R++ + E+ Q E E + EK IHE+++ +R+Q
Sbjct: 500 MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK-IHEQEEK---IRKQ 555
Query: 389 LEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEA 448
E++ +K+ E+ ++E+ E + R EEK + +R+ E+++++ E+ E
Sbjct: 556 EEKM----WRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQ 611
Query: 449 ED----------EDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDL 498
E+ E E+ +QE K +++I ++EK++ + E ++ ++E Q +E +
Sbjct: 612 EEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 671
Query: 499 QKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKI-YHEQEQALQE 545
++++ + + Q+ ++E + Q+E +++ +QE+ +QE
Sbjct: 672 WEQEEKMCEQEEKMQE----QEEKMRRQEEKMWEQEVRLRQQEEKMQE 715
Score = 54.7 bits (130), Expect = 3e-07
Identities = 58/284 (20%), Positives = 129/284 (45%), Gaps = 27/284 (9%)
Query: 220 KNEEDIGNKE-RNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 278
+ EE I +E R Q A + Q+ + E ++ + + + + + EE
Sbjct: 461 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE--- 517
Query: 279 AKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARR 338
K QE+ R E K+ ++ E+ + + Q K +Q ++M+ + +
Sbjct: 518 ------KRQEQEEMWRQEEKI-----REQEEIWRQKEKIHEQEEKIRKQE-EKMWRQEEK 565
Query: 339 QLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIE 398
E ++R+ E ++ Q E E ++ E+ I E+++ +++ E + E
Sbjct: 566 MHDQEEKIREQ-EEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 624
Query: 399 MYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAED---EDEKY 455
+K+Q E+ ++ + E I E+K + +R+ E+ +Q+ E+ E E+ E E+
Sbjct: 625 QEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
Query: 456 LQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQ 499
+QE ++++ ++E+++ + E L+ ++E Q QE L+
Sbjct: 685 MQE-------QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 34.3 bits (77), Expect = 0.36
Identities = 34/130 (26%), Positives = 61/130 (46%), Gaps = 9/130 (6%)
Query: 427 ITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKI 486
+T +L+ L ++ A + E E ++ +S+ K + E+ L + T
Sbjct: 196 LTCQKTELQMALYYSQHAVKQLEGE----ARDLISRLHDSWKFAGELEQALSAVAT---- 247
Query: 487 EKEWRQTLQEDLQKEKDALS-HLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQE 545
+K+ E+L KE+DALS L T LK++ LQ++ Q ++ E + ++E
Sbjct: 248 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 307
Query: 546 LGNKLSESKL 555
L KL +KL
Sbjct: 308 LKRKLERAKL 317
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 87.0 bits (214), Expect = 5e-17
Identities = 76/361 (21%), Positives = 181/361 (50%), Gaps = 19/361 (5%)
Query: 234 IAAILDQKN----YVEELNRQLNSTVSSLHSRV---DSLEKSNTKLIEELAIAKNNIIKL 286
++A+ QK Y+EEL ++ ++ L+ + L++ N KL E+L + ++ ++
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 240
Query: 287 QEENHQLRSE-NKLILMKTQQHLEVTKVDVETELQTYKHSRQGL---DEMYNEARRQLRD 342
Q +L+ + + L+ QQ L+ + ELQ+ Q +E++N +Q +
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 300
Query: 343 ----ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIE 398
+ + Q+ E ++ Q E E ++ E+ + +++ + +++ + + E
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 399 MYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEK-AQMEAEDEDEKYLQ 457
+K++ E+ + EK E + R EE + +R+LE+++ + EK + E + ++E+ ++
Sbjct: 361 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 420
Query: 458 ECLSKSDSLQKQISQKEKQLVQLETDLKIEKE-WRQTLQEDLQKEKDALSHLRNETQQII 516
E + + K Q+EK Q E + EK+ WRQ +E + +++ + + Q+ +
Sbjct: 421 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ--EEKIHEQEKIREEEKRQEQEEM 478
Query: 517 SLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDK 576
++E ++ Q+E + K+ HEQE+ +++ K+ + KI + +E + + +W +++
Sbjct: 479 WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEE 538
Query: 577 E 577
+
Sbjct: 539 K 539
Score = 72.0 bits (175), Expect = 2e-12
Identities = 74/403 (18%), Positives = 190/403 (47%), Gaps = 28/403 (6%)
Query: 220 KNEEDIGNKERNVQIAA--ILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELA 277
+ EE I E +Q I +Q+ + E ++ + + + + + + E+
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 278 IAKNNIIKLQEENHQLRSENKLILMKTQQHLEVT-KVDVETELQTYKHSRQGLDEMYNEA 336
+ + E+ ++R + +++ K ++ E+ K+ + +++ + RQ +++ +
Sbjct: 364 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 423
Query: 337 RRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIG-LRQQLEEVKAI 395
+RQ ++ RQ E ++ Q E E M E+ IHE++ RQ+ EE+
Sbjct: 424 KRQEQEAKMWRQ--EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ 481
Query: 396 NIEMYQ---------KLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQM 446
++++ K+ E+ ++++ E + R EEK + +R+ E+++ + E+
Sbjct: 482 EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIR 541
Query: 447 EAED----EDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQT--LQEDLQK 500
E E+ E++ + QE + + + Q+Q + +Q ++ + EK WRQ ++E +K
Sbjct: 542 EQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIRE--QEEKVWRQEEKIREQEEK 599
Query: 501 EKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDI 560
++ + + ++I +++ +++ ++ ++ EQE+ QE K+ E + K+ +
Sbjct: 600 RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQ 659
Query: 561 KEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNCGEI 603
+E + + +W +++ K+ E+E + +++ R E+
Sbjct: 660 EEKMQEQEETMWRQEE-----KIREQEKKIREQEEKIREQEEM 697
Score = 66.6 bits (161), Expect = 7e-11
Identities = 69/332 (20%), Positives = 155/332 (46%), Gaps = 29/332 (8%)
Query: 220 KNEEDIGNKERNV--QIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELA 277
+ EE I +E+ + Q I +Q+ EE RQ + + + K+ E+
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ----------EQEEMWRQEEKIHEQEE 490
Query: 278 IAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEAR 337
I + K+ E+ ++R + + + +Q ++ + + + Q K RQ +E E
Sbjct: 491 IWRQKE-KMHEQEEKIRKQEEKVW---RQEEKIREQEEKIREQEEKMWRQ--EEKIREQE 544
Query: 338 RQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINI 397
R+E ++ E E + + E E M E+ I E+++ + +++ E +
Sbjct: 545 EMWREEEKMH---EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ 601
Query: 398 EMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAED---EDEK 454
E +K+ E+ ++E+ E I EEK + +R+ E+ Q+ E+ E E+ E E+
Sbjct: 602 EQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 661
Query: 455 YLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQ 514
+QE +++I ++EK++ + E ++ ++E Q +E + ++++ + + Q+
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 721
Query: 515 IISLKKEFLNLQDENQQLKKI-YHEQEQALQE 545
++E + Q+E +++ +QE+ +QE
Sbjct: 722 ----QEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 63.2 bits (152), Expect = 7e-10
Identities = 59/303 (19%), Positives = 143/303 (47%), Gaps = 21/303 (6%)
Query: 285 KLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYK---------HSRQGL---DEM 332
K++E+ ++R + K + + ++ E K+ E + Q + H ++ + E
Sbjct: 438 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEK 497
Query: 333 YNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEV 392
+E ++R + + E ++ Q E E M E+ I E+++ + E+
Sbjct: 498 MHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQE 557
Query: 393 KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAED-- 450
K I +K Q ED + + E I EEK + +R+ E++ Q+ E+ + E+
Sbjct: 558 K---IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 451 -EDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLR 509
E E+ +QE K +++I ++E+ + E + ++E +E +Q++++ +
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEET---MW 671
Query: 510 NETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQG 569
+ ++I +K+ +++ ++ +++ EQE+ + E K+ E + K+++ +E + +
Sbjct: 672 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 731
Query: 570 LVW 572
+W
Sbjct: 732 KMW 734
Score = 46.6 bits (109), Expect = 7e-05
Identities = 43/238 (18%), Positives = 104/238 (43%), Gaps = 3/238 (1%)
Query: 220 KNEEDIGNKERNV--QIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELA 277
+ EE I +E + Q + Q+ + E ++ +H + E+ + E+
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEKIRE-QEEMWREEEKMHEQEKIWEEEKRQEQEDKM 572
Query: 278 IAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEAR 337
+ I+ QEE + E + +Q E E +++ + Q +E E
Sbjct: 573 WRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE 632
Query: 338 RQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINI 397
++R++ ++ Q+ E ++ Q E E M+ E+ + +++ + +++ E +
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 398 EMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKY 455
E + +Q E+ + E+ E + EEK + MR+ E+++ + E + E++ +++
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
Score = 34.3 bits (77), Expect = 0.36
Identities = 34/130 (26%), Positives = 61/130 (46%), Gaps = 9/130 (6%)
Query: 427 ITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKI 486
+T +L+ L ++ A + E E ++ +S+ K + E+ L + T
Sbjct: 135 LTCQKTELQMALYYSQHAVKQLEGE----ARDLISRLHDSWKFAGELEQALSAVAT---- 186
Query: 487 EKEWRQTLQEDLQKEKDALS-HLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQE 545
+K+ E+L KE+DALS L T LK++ LQ++ Q ++ E + ++E
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 546 LGNKLSESKL 555
L KL +KL
Sbjct: 247 LKRKLERAKL 256
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 85.5 bits (210), Expect = 1e-16
Identities = 84/383 (21%), Positives = 192/383 (50%), Gaps = 31/383 (8%)
Query: 234 IAAILDQKN----YVEELNRQLNSTVSSLHSRV---DSLEKSNTKLIEELAIAKNNIIKL 286
++A+ QK Y+EEL ++ ++ L+ + L++ N KL E+L + ++ ++
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 240
Query: 287 QEENHQLRSE-NKLILMKTQQHLEVTKVDVETELQTYKHSRQGL---DEMYNEARRQLRD 342
Q +L+ + + L+ QQ L+ + ELQ+ Q +E++N +Q ++
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ-QE 299
Query: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
E RQ+ + + E E ++ E+ I E+++ + +++ + + E +K
Sbjct: 300 EKMWRQEEKIQ---------EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 350
Query: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEK-AQMEAEDEDEKYLQECLS 461
++ E+ + EK E + RLEE + +R+LE+++ + EK + E + ++E+ ++E
Sbjct: 351 MRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410
Query: 462 KSDSLQKQISQKEKQLVQLETDLKIEKE-WRQTLQEDLQKEKDALSHLRNETQQIISLKK 520
+ + K Q+EK Q E + EK+ WRQ +E + +++ + + Q+ + ++
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ--EEKIHEQEKIREEEKRQEQEEMWRQE 468
Query: 521 EFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATH 580
E + Q+E + K+ HEQE+ +++ K+ + K+ D +E + + +W +++
Sbjct: 469 EKIREQEEIWRQKEKMHEQEK-IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEE---- 523
Query: 581 CKLCEKEFSLSKRKHHCRNCGEI 603
K+ E+E + +++ R E+
Sbjct: 524 -KIREQEEKIREQEEKIREQEEM 545
Score = 76.3 bits (186), Expect = 8e-14
Identities = 109/530 (20%), Positives = 242/530 (45%), Gaps = 89/530 (16%)
Query: 113 VEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMAD-YLRCLIIQRDLLS-EF 170
V++L EA ++ + + D L +A L QKK AD Y+ L +RD LS E
Sbjct: 153 VKQLEGEARDLISRLHDSWKFAGELEQA---LSAVATQKKKADRYIEELTKERDALSLEL 209
Query: 171 YEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKE- 229
Y + D L K L ++ +++ K+E + KE
Sbjct: 210 YRN-------------------TITDEELKEKNAKLQEKLQLVESE---KSEIQLNVKEL 247
Query: 230 -RNVQIAAILDQKNYVE----ELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNII 284
R ++ A +L + ++ L ++L S + L ++V+ E N +
Sbjct: 248 KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR-------------L 294
Query: 285 KLQEENHQLRSENKLILMKTQQHLEVTKV-DVETELQTYKHSRQGLDEMYNEARRQLRDE 343
Q+E R E K+ + + + K+ + E +++ + + +EM E ++R +
Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354
Query: 344 SQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQ-----------DTLIGLRQQLEEV 392
++ + E ++ M E E ++ LE+ +HE++ + I +++ +E
Sbjct: 355 EEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 414
Query: 393 KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDED 452
+A +K++ E+ ++E+ + + R EEK ++ +R+ E+R +Q E + E + +
Sbjct: 415 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE-QEKIREEEKRQEQEEMWRQEEKIRE 473
Query: 453 EKYL---QECLSKSDSLQKQ---ISQKEKQLVQLETDLKIEKE--WRQT--LQEDLQKEK 502
++ + +E + + + ++KQ + ++E+++ E ++ ++E WRQ ++E +K +
Sbjct: 474 QEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR 533
Query: 503 DALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKI----- 557
+ +R E ++++ ++E + Q+E Q ++ QE+ ++E K+ E K KI
Sbjct: 534 EQEEKIR-EQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEE 592
Query: 558 ------EDIKEANKALQ---GLVWLKDKEATHCKLCEKEFSLSKRKHHCR 598
E I+E + +Q +W +++ K+CE+E + +++ R
Sbjct: 593 KIWEQEEKIREQEEMMQEQEEKMWEQEE-----KMCEQEEKMQEQEEKMR 637
Score = 61.2 bits (147), Expect = 3e-09
Identities = 62/308 (20%), Positives = 143/308 (46%), Gaps = 22/308 (7%)
Query: 244 VEELNRQLNSTVSSLHSRVDSLEK---SNTKLIEELAIAKNNIIKLQEENHQLRSENKLI 300
+EE+ + + L ++ EK K EE I + K QE+ ++ + + I
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE--KRQEQEAKMWRQEEKI 425
Query: 301 LMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM 360
+ ++ E K E + ++ + +E E R E ++R+ + E+ Q
Sbjct: 426 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE--QEEIWRQKEK 483
Query: 361 KHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARL 420
HE E K EK +++ + Q E+++ E +K+ E+ ++E+ E I
Sbjct: 484 MHEQEKIRKQEEKVWRQEEK----MHDQEEKIR----EQEEKMWRQEEKIREQEEKIREQ 535
Query: 421 EEKTNKITAAMRQLEQRLQQAEKAQMEAED--EDEKYLQECLSKSDSLQKQISQKEKQLV 478
EEK + M++ E+++ + E+ E E E+ ++E K +++I ++E+++
Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW 595
Query: 479 QLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKI-YH 537
+ E ++ ++E Q +E + ++++ + + Q+ ++E + Q+E +++
Sbjct: 596 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE----QEEKMRRQEEKMWEQEVRLR 651
Query: 538 EQEQALQE 545
+QE+ +QE
Sbjct: 652 QQEEKMQE 659
Score = 60.8 bits (146), Expect = 4e-09
Identities = 70/366 (19%), Positives = 174/366 (47%), Gaps = 39/366 (10%)
Query: 222 EEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLI--EELAIA 279
E ++ N+ Q + Q+ ++E ++ + + + + + K+ EE+
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 346
Query: 280 KNNIIKLQEE-----NHQLRSENKLILMKTQQHLEVT-KVDVETELQTYKHSRQGLDEMY 333
K ++ QEE ++R +++ K ++ E+ K+ + +++ + RQ +++
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 406
Query: 334 NEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVK 393
+ +RQ ++ RQ E ++ Q E E M E+ IHE++ ++Q +E
Sbjct: 407 EQEKRQEQEAKMWRQ--EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE-- 462
Query: 394 AINIEMY---QKLQGSEDGLKEKNEI-----IARLEEKTNKITAAMRQLEQRLQQAEKAQ 445
EM+ +K++ E+ ++K ++ I + EEK + M E+++++ E+
Sbjct: 463 ----EMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKM 518
Query: 446 MEAED---EDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWR---QTLQEDLQ 499
E+ E E+ ++E K ++ + ++E+++ + E ++ +++ R + ++E +
Sbjct: 519 WRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEE 578
Query: 500 KEKDALSHLRNETQQI------ISLKKEFLNLQDEN--QQLKKIYHEQEQALQELGNKLS 551
K ++ +R + ++I I ++E + Q+E +Q +K+ EQE+ +QE K+
Sbjct: 579 KIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMC-EQEEKMQEQEEKMR 637
Query: 552 ESKLKI 557
+ K+
Sbjct: 638 RQEEKM 643
Score = 47.0 bits (110), Expect = 5e-05
Identities = 50/253 (19%), Positives = 112/253 (44%), Gaps = 23/253 (9%)
Query: 220 KNEEDIGNKERNV--QIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELA 277
+ EE I +E+ + Q I +Q+ EE RQ + + + K+ E+
Sbjct: 427 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ----------EQEEMWRQEEKIREQEE 476
Query: 278 IAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKV-DVETELQTYKHSRQGLDEMYNEA 336
I + K+ E+ + E K+ + + H + K+ + E ++ + + +E E
Sbjct: 477 IWRQKE-KMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ 535
Query: 337 RRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEK------DIHEKQDTLIGLRQQLE 390
++R++ ++ Q+ E ++ Q E E + EK I E+++ + +++
Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW 595
Query: 391 EVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAE---KAQME 447
E + E + +Q E+ + E+ E + EEK + MR+ E+++ + E + Q E
Sbjct: 596 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 655
Query: 448 AEDEDEKYLQECL 460
E +++L+ +
Sbjct: 656 KMQEHQEHLEAAI 668
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 82.8 bits (203), Expect = 9e-16
Identities = 80/343 (23%), Positives = 161/343 (46%), Gaps = 42/343 (12%)
Query: 238 LDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSEN 297
++QK +E LN+Q + + L S D + KS +L + + + +++ + +L E
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE- 1547
Query: 298 KLILMKTQQHLEVTKVDVETELQTYK----HSRQGLDEMYNEARRQL-RDESQLRQDVEN 352
Q E K+ +E LQ K QG DE E ++QL R ++ ++E+
Sbjct: 1548 -------LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 353 EL---AVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDG 409
E ++ V+ + ++E+ +K LE I +QL +++A +M ++ +D
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA---QMKDCMRELDDT 1657
Query: 410 LKEKNEIIARLEEKTNKIT---AAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSL 466
+ EI+A+ +E K+ A M QL++ L AE+A+ +A+ E ++ E + S
Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKG 1717
Query: 467 QKQISQK---EKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFL 523
+ +K E ++ QLE +L+ E+ + + + L+K + + + L
Sbjct: 1718 ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD-----------L 1766
Query: 524 NLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKA 566
NL+ + Q + E A Q+L + E K+K+++++ K+
Sbjct: 1767 NLERSHAQ------KNENARQQLERQNKELKVKLQEMEGTVKS 1803
Score = 73.9 bits (180), Expect = 4e-13
Identities = 73/338 (21%), Positives = 154/338 (45%), Gaps = 38/338 (11%)
Query: 274 EELAIAKNNIIKLQEENHQLRSENKLILMKT-QQHLEVTKVDVETELQTYKH-------- 324
EE+ + ++K++E+ QL +EN+L M+T Q L K+ ++ +LQ
Sbjct: 845 EEMMAKEEELVKVREK--QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902
Query: 325 ------SRQGLDEMYNEARRQLRDE--------------SQLRQDVENELAVQVSMKHEI 364
+Q L+E+ ++ ++ +E Q Q++E +L + S + ++
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 365 ELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKT 424
+L E + + ++ I L Q ++ + ++ L E+ E L +
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022
Query: 425 NKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDL 484
NK A + LE+RL++ EK + E EK ++ S L QI++ + Q+ +L+ L
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQEL----EKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078
Query: 485 KIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQ 544
++E LQ L + ++ + ++I L+ + LQ++ + + ++ E+ +
Sbjct: 1079 AKKEE---ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135
Query: 545 ELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
+LG +L K ++ED ++ A Q L +++E K
Sbjct: 1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Score = 62.0 bits (149), Expect = 2e-09
Identities = 90/413 (21%), Positives = 169/413 (40%), Gaps = 65/413 (15%)
Query: 205 DLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDS 264
+L +Q+ + + K EE R + AA QKN + R+L S +S L ++S
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAA---QKNMALKKIRELESQISELQEDLES 1122
Query: 265 -------LEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVET 317
EK L EEL K + E+ + + + K +Q + + K +E
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTEL----EDTLDSTAAQQELRSKREQEVNILKKTLEE 1178
Query: 318 ELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHE 377
E +T++ Q + + +++A +L ++ + + V K +E A + LE + E
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV----------KANLEKAKQTLENERGE 1228
Query: 378 KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR 437
+ EVK + LQG D ++ ++ A+L+E K R +
Sbjct: 1229 LAN----------EVKVL-------LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 438 LQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQL--------------VQLETD 483
+ K Q+E D L + SKS L K S E QL + L T
Sbjct: 1272 ADKVTKLQVEL-DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 484 LK-IEKE---WRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQ 539
LK +E E +R+ L+E+ + + + + Q+ +KK+ + + +++ +
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 540 EQALQELGNKLSESKLKIEDIKEANKALQG-----LVWLKDKEATHCKLCEKE 587
++ L+ L + E + +++ LQ LV L + + C L +K+
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Score = 58.5 bits (140), Expect = 2e-08
Identities = 60/255 (23%), Positives = 126/255 (49%), Gaps = 26/255 (10%)
Query: 356 VQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIE-MYQKLQGSEDGLKEKN 414
+QVS + E +A + + EKQ + +L E++ + + M +KLQ E L+ +
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQ---LAAENRLTEMETLQSQLMAEKLQLQEQ-LQAET 893
Query: 415 EIIARLEEKTNKITAAMRQLEQ-------RLQQAEKAQMEAEDEDEKYLQECLSKSDSLQ 467
E+ A EE ++TA ++LE+ R+++ E+ + E +K Q + L+
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 468 KQISQKEK-QLVQLETDLKIEK-EWRQTLQED----LQKEKDALSHLRNETQQIISLKKE 521
++ S ++K QL ++ T+ K++K E Q + ED L KEK L +I
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE------DRIAEFTTN 1007
Query: 522 FLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQG-LVWLKDKEA-T 579
+++++ L K+ ++ E + +L +L + + +++++ + L+G L D+ A
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 580 HCKLCEKEFSLSKRK 594
++ E + L+K++
Sbjct: 1068 QAQIAELKMQLAKKE 1082
Score = 56.2 bits (134), Expect = 9e-08
Identities = 83/368 (22%), Positives = 155/368 (42%), Gaps = 66/368 (17%)
Query: 233 QIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKL---IEELAIAKNNIIKLQEE 289
++ +L K E +++ + + L + + E+ T+L + +L + +N+ L +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 290 NHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQD 349
+ S+ L K LE D + LQ + +RQ L + +Q+ DE +
Sbjct: 1292 SDSKSSK----LTKDFSALESQLQDTQELLQ--EENRQKLS--LSTKLKQVEDE---KNS 1340
Query: 350 VENELAVQVSMKHEIELAMKLLE---KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGS 406
+L + KH +E + L D+ +K + +G + EEVK +KLQ
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK-------RKLQKD 1393
Query: 407 EDGLKEKNEIIARLEEKTNKITAAMRQ--------LEQRLQQA---EKAQ---------- 445
+GL +++E +K K ++Q L+ + Q A EK Q
Sbjct: 1394 LEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 446 -------MEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDL 498
E D E +E +K+ SL + + + +Q +LE ++ K++R T EDL
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE---RLNKQFR-TEMEDL 1509
Query: 499 QKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIE 558
KD + + + L+K L+ + +++K E E LQ ++KL++E
Sbjct: 1510 MSSKDDVG------KSVHELEKSKRALEQQVEEMKTQLEELEDELQ----ATEDAKLRLE 1559
Query: 559 DIKEANKA 566
+A KA
Sbjct: 1560 VNLQAMKA 1567
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 82.0 bits (201), Expect = 2e-15
Identities = 72/347 (20%), Positives = 158/347 (45%), Gaps = 26/347 (7%)
Query: 250 QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLE 309
Q+ + ++ D L+K+ E A+N + +L++++ QL E L+ + Q E
Sbjct: 846 QVTRQEEEMQAKEDELQKTK----ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 310 VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQ--------------DVENELA 355
+ E ++ +Q L+E+ +E +L +E Q D+E +L
Sbjct: 902 LYAEAEEMRVRLAA-KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 356 VQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNE 415
+ + + +++L E I + +D ++ + Q ++ + +++ L E+ E
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 416 IIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEK 475
L + NK + + +LE RL++ EK++ E EK ++ + +QI+ +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQA 1076
Query: 476 QLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKI 535
Q+ +L+ L ++E LQ L + D ++ N ++I L+ +LQ++ +
Sbjct: 1077 QIAELKMQLAKKEE---ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 536 YHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
++ E+ ++LG +L K ++ED ++ Q L +++E T K
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Score = 71.6 bits (174), Expect = 2e-12
Identities = 72/315 (22%), Positives = 139/315 (44%), Gaps = 38/315 (12%)
Query: 287 QEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 346
QEE Q + + L KT++ + E EL+ + L E N + QL+ E++L
Sbjct: 850 QEEEMQAKEDE---LQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 347 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDT--------------LIGLRQQLEEV 392
+ E + K E+E + +E + E++D ++ L +QLEE
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 393 KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDED 452
+A ++ + +E +K+ + I ++++ NK++ + LE+R+ E E+
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE-- 1020
Query: 453 EKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNET 512
K+ +L K ++ E + +LE LK E++ RQ L++ +K + S
Sbjct: 1021 ---------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH--- 1068
Query: 513 QQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVW 572
+QI L+ + L+ QL K E + AL L +++++ ++ I+E + L
Sbjct: 1069 EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 573 LKDKEATHCKLCEKE 587
D E EK+
Sbjct: 1126 DLDSERAARNKAEKQ 1140
Score = 71.2 bits (173), Expect = 3e-12
Identities = 88/400 (22%), Positives = 175/400 (43%), Gaps = 57/400 (14%)
Query: 220 KNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIA 279
K E + K+ Q+ + + + E +LN V L + V+S+ T ++ E A
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----TGMLNE---A 1299
Query: 280 KNNIIKLQEE----NHQLRSENKLILMKTQQHLEVT---------KVDVETELQTYKHSR 326
+ IKL ++ + QL+ +L+ +T+Q L V+ + ++ +L ++
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 327 QGLDEMYNEARRQLRDESQLRQDV--------------ENELAVQVSMKHEIELAMKLLE 372
Q L+ + QL D + QD + E+ E A LE
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 373 KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMR 432
K + Q L L L+ + + + +K + + L E+ I ++ ++ ++ A R
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 433 QLEQR---LQQAEKAQMEAEDEDEKY-------LQECLSKSDSLQKQISQKEKQLVQLET 482
+ E + L +A + +EA++E E+ +++ +S D + K + + EK LET
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 483 DLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDE-----NQQLKKIYH 537
++ K + L+++LQ +DA L Q + + L +DE +QL++ H
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 538 EQEQALQELGNK---LSESKLKIE-DIK----EANKALQG 569
E E L++ + + +K K+E D+K +A+ A++G
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Score = 61.2 bits (147), Expect = 3e-09
Identities = 81/376 (21%), Positives = 154/376 (40%), Gaps = 36/376 (9%)
Query: 207 DSQVGVIDFSMYLKNEEDIGNKERNVQIAAILD---QKNYVEELNRQLNSTVSSLHSRVD 263
D Q + + M L +E+ E +A + D QKN + R+L +S L +D
Sbjct: 1073 DLQAQIAELKMQLAKKEE----ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 264 SLEKSNTKLIEELAIAKNNIIKLQEENHQLRSE--NKLILMKTQQHLEVTKVDVETELQT 321
S + K A+ L EE L++E + L TQQ L + T L
Sbjct: 1129 SERAARNK-------AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL-- 1179
Query: 322 YKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM----KHEIELAMKLLEKDIHE 377
++ LDE Q+++ Q EL Q+ K ++ + LEK+ +
Sbjct: 1180 ----KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 378 KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR 437
L L Q +EV+ ++ ++Q + + A L +K +K+ + +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 438 LQQAE-KAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQE 496
L +AE KA A+D + S+ Q+ + ++ +Q + + T L+ +E R +LQ+
Sbjct: 1296 LNEAEGKAIKLAKD-----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 497 DLQKEKDALSHLRNETQ----QIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSE 552
L +E +A +L Q+ KK+ + + L++ ++ ++ L + E
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 553 SKLKIEDIKEANKALQ 568
+ +++ LQ
Sbjct: 1411 KAAAYDKLEKTKNRLQ 1426
Score = 58.2 bits (139), Expect = 2e-08
Identities = 75/411 (18%), Positives = 173/411 (42%), Gaps = 59/411 (14%)
Query: 219 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLH---SRVDSLEKSNTKLIEE 275
L+ E + + + ++ A + + ++ LN QL+ + L S V++LE+ + +E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 276 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKH---SRQGLDEM 332
+ N+ + EE + + + QQ L+ VD++ + Q + ++ D++
Sbjct: 1401 I----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456
Query: 333 YNE--------------ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLE------ 372
E A + R++ + L + K E+E K+L+
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 373 --------KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKE------------ 412
K++HE + + L Q+EE+K E+ +LQ +ED
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 413 KNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQME------AEDEDEKYLQECLSKSDSL 466
+ ++ AR E+ K RQL + + E + + A+ + E L++ ++DS
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 467 QKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQ 526
K + KQL +L+ +K ++++ L++ + + + ++ SL+ + + LQ
Sbjct: 1637 IKGREEAIKQLRKLQAQMK---DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 527 DENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKE 577
++ ++ + + +EL +L+ S +++ + L+ + ++E
Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Score = 57.4 bits (137), Expect = 4e-08
Identities = 81/426 (19%), Positives = 174/426 (40%), Gaps = 71/426 (16%)
Query: 213 IDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKL 272
++ ++ K E + NK ++ ++ K+ V + +L + +L ++++ ++ +L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 273 IEELAIAKNNIIKLQ------------------EENHQLRSENKLILMKTQQHLE----- 309
+EL ++ ++L+ E+N + R + + L + + LE
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 310 -----VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEI 364
K +E +L+ + + EA +QLR +D + EL + + EI
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 365 -------ELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLK----EK 413
E K LE D+ + Q+ L + ++ E+ ++L S G EK
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 414 NEIIAR-------LEEKTNKITAAMRQLEQRLQQAEKAQME-------------AEDEDE 453
+ AR LEE+ + A ++ + QQAE+ E A + E
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 454 KYLQECLSKSDSLQKQISQK--------EKQLVQLETDLKIEKEWRQTLQEDLQKE---- 501
+ +E SK ++ + K E ++ QLE ++ E +Q + L+++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 502 KDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIK 561
K+ L + +E + K++ +QLK+ E E+ Q + + + ++++
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 562 EANKAL 567
E+N+A+
Sbjct: 1912 ESNEAM 1917
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 82.0 bits (201), Expect = 2e-15
Identities = 72/347 (20%), Positives = 158/347 (45%), Gaps = 26/347 (7%)
Query: 250 QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLE 309
Q+ + ++ D L+K+ E A+N + +L++++ QL E L+ + Q E
Sbjct: 853 QVTRQEEEMQAKEDELQKTK----ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 310 VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQ--------------DVENELA 355
+ E ++ +Q L+E+ +E +L +E Q D+E +L
Sbjct: 909 LYAEAEEMRVRLAA-KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 356 VQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNE 415
+ + + +++L E I + +D ++ + Q ++ + +++ L E+ E
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 416 IIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEK 475
L + NK + + +LE RL++ EK++ E EK ++ + +QI+ +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQA 1083
Query: 476 QLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKI 535
Q+ +L+ L ++E LQ L + D ++ N ++I L+ +LQ++ +
Sbjct: 1084 QIAELKMQLAKKEE---ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 536 YHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
++ E+ ++LG +L K ++ED ++ Q L +++E T K
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Score = 71.6 bits (174), Expect = 2e-12
Identities = 72/315 (22%), Positives = 139/315 (44%), Gaps = 38/315 (12%)
Query: 287 QEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 346
QEE Q + + L KT++ + E EL+ + L E N + QL+ E++L
Sbjct: 857 QEEEMQAKEDE---LQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 347 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDT--------------LIGLRQQLEEV 392
+ E + K E+E + +E + E++D ++ L +QLEE
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 393 KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDED 452
+A ++ + +E +K+ + I ++++ NK++ + LE+R+ E E+
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE-- 1027
Query: 453 EKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNET 512
K+ +L K ++ E + +LE LK E++ RQ L++ +K + S
Sbjct: 1028 ---------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH--- 1075
Query: 513 QQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVW 572
+QI L+ + L+ QL K E + AL L +++++ ++ I+E + L
Sbjct: 1076 EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 573 LKDKEATHCKLCEKE 587
D E EK+
Sbjct: 1133 DLDSERAARNKAEKQ 1147
Score = 71.2 bits (173), Expect = 3e-12
Identities = 88/400 (22%), Positives = 175/400 (43%), Gaps = 57/400 (14%)
Query: 220 KNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIA 279
K E + K+ Q+ + + + E +LN V L + V+S+ T ++ E A
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----TGMLNE---A 1306
Query: 280 KNNIIKLQEE----NHQLRSENKLILMKTQQHLEVT---------KVDVETELQTYKHSR 326
+ IKL ++ + QL+ +L+ +T+Q L V+ + ++ +L ++
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 327 QGLDEMYNEARRQLRDESQLRQDV--------------ENELAVQVSMKHEIELAMKLLE 372
Q L+ + QL D + QD + E+ E A LE
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 373 KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMR 432
K + Q L L L+ + + + +K + + L E+ I ++ ++ ++ A R
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 433 QLEQR---LQQAEKAQMEAEDEDEKY-------LQECLSKSDSLQKQISQKEKQLVQLET 482
+ E + L +A + +EA++E E+ +++ +S D + K + + EK LET
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 483 DLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDE-----NQQLKKIYH 537
++ K + L+++LQ +DA L Q + + L +DE +QL++ H
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 538 EQEQALQELGNK---LSESKLKIE-DIK----EANKALQG 569
E E L++ + + +K K+E D+K +A+ A++G
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Score = 61.2 bits (147), Expect = 3e-09
Identities = 81/376 (21%), Positives = 154/376 (40%), Gaps = 36/376 (9%)
Query: 207 DSQVGVIDFSMYLKNEEDIGNKERNVQIAAILD---QKNYVEELNRQLNSTVSSLHSRVD 263
D Q + + M L +E+ E +A + D QKN + R+L +S L +D
Sbjct: 1080 DLQAQIAELKMQLAKKEE----ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 264 SLEKSNTKLIEELAIAKNNIIKLQEENHQLRSE--NKLILMKTQQHLEVTKVDVETELQT 321
S + K A+ L EE L++E + L TQQ L + T L
Sbjct: 1136 SERAARNK-------AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL-- 1186
Query: 322 YKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM----KHEIELAMKLLEKDIHE 377
++ LDE Q+++ Q EL Q+ K ++ + LEK+ +
Sbjct: 1187 ----KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 378 KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR 437
L L Q +EV+ ++ ++Q + + A L +K +K+ + +
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 438 LQQAE-KAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQE 496
L +AE KA A+D + S+ Q+ + ++ +Q + + T L+ +E R +LQ+
Sbjct: 1303 LNEAEGKAIKLAKD-----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 497 DLQKEKDALSHLRNETQ----QIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSE 552
L +E +A +L Q+ KK+ + + L++ ++ ++ L + E
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 553 SKLKIEDIKEANKALQ 568
+ +++ LQ
Sbjct: 1418 KAAAYDKLEKTKNRLQ 1433
Score = 58.2 bits (139), Expect = 2e-08
Identities = 75/411 (18%), Positives = 173/411 (42%), Gaps = 59/411 (14%)
Query: 219 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLH---SRVDSLEKSNTKLIEE 275
L+ E + + + ++ A + + ++ LN QL+ + L S V++LE+ + +E
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 276 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKH---SRQGLDEM 332
+ N+ + EE + + + QQ L+ VD++ + Q + ++ D++
Sbjct: 1408 I----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463
Query: 333 YNE--------------ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLE------ 372
E A + R++ + L + K E+E K+L+
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 373 --------KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKE------------ 412
K++HE + + L Q+EE+K E+ +LQ +ED
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 413 KNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQME------AEDEDEKYLQECLSKSDSL 466
+ ++ AR E+ K RQL + + E + + A+ + E L++ ++DS
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 467 QKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQ 526
K + KQL +L+ +K ++++ L++ + + + ++ SL+ + + LQ
Sbjct: 1644 IKGREEAIKQLRKLQAQMK---DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 527 DENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKE 577
++ ++ + + +EL +L+ S +++ + L+ + ++E
Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Score = 57.4 bits (137), Expect = 4e-08
Identities = 81/426 (19%), Positives = 174/426 (40%), Gaps = 71/426 (16%)
Query: 213 IDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKL 272
++ ++ K E + NK ++ ++ K+ V + +L + +L ++++ ++ +L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 273 IEELAIAKNNIIKLQ------------------EENHQLRSENKLILMKTQQHLE----- 309
+EL ++ ++L+ E+N + R + + L + + LE
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 310 -----VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEI 364
K +E +L+ + + EA +QLR +D + EL + + EI
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 365 -------ELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLK----EK 413
E K LE D+ + Q+ L + ++ E+ ++L S G EK
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 414 NEIIAR-------LEEKTNKITAAMRQLEQRLQQAEKAQME-------------AEDEDE 453
+ AR LEE+ + A ++ + QQAE+ E A + E
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 454 KYLQECLSKSDSLQKQISQK--------EKQLVQLETDLKIEKEWRQTLQEDLQKE---- 501
+ +E SK ++ + K E ++ QLE ++ E +Q + L+++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 502 KDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIK 561
K+ L + +E + K++ +QLK+ E E+ Q + + + ++++
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918
Query: 562 EANKAL 567
E+N+A+
Sbjct: 1919 ESNEAM 1924
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 82.0 bits (201), Expect = 2e-15
Identities = 72/347 (20%), Positives = 158/347 (45%), Gaps = 26/347 (7%)
Query: 250 QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLE 309
Q+ + ++ D L+K+ E A+N + +L++++ QL E L+ + Q E
Sbjct: 853 QVTRQEEEMQAKEDELQKTK----ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 310 VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQ--------------DVENELA 355
+ E ++ +Q L+E+ +E +L +E Q D+E +L
Sbjct: 909 LYAEAEEMRVRLAA-KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 356 VQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNE 415
+ + + +++L E I + +D ++ + Q ++ + +++ L E+ E
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 416 IIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEK 475
L + NK + + +LE RL++ EK++ E EK ++ + +QI+ +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQA 1083
Query: 476 QLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKI 535
Q+ +L+ L ++E LQ L + D ++ N ++I L+ +LQ++ +
Sbjct: 1084 QIAELKMQLAKKEE---ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 536 YHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
++ E+ ++LG +L K ++ED ++ Q L +++E T K
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Score = 71.6 bits (174), Expect = 2e-12
Identities = 72/315 (22%), Positives = 139/315 (44%), Gaps = 38/315 (12%)
Query: 287 QEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 346
QEE Q + + L KT++ + E EL+ + L E N + QL+ E++L
Sbjct: 857 QEEEMQAKEDE---LQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 347 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDT--------------LIGLRQQLEEV 392
+ E + K E+E + +E + E++D ++ L +QLEE
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 393 KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDED 452
+A ++ + +E +K+ + I ++++ NK++ + LE+R+ E E+
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE-- 1027
Query: 453 EKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNET 512
K+ +L K ++ E + +LE LK E++ RQ L++ +K + S
Sbjct: 1028 ---------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH--- 1075
Query: 513 QQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVW 572
+QI L+ + L+ QL K E + AL L +++++ ++ I+E + L
Sbjct: 1076 EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 573 LKDKEATHCKLCEKE 587
D E EK+
Sbjct: 1133 DLDSERAARNKAEKQ 1147
Score = 71.2 bits (173), Expect = 3e-12
Identities = 88/400 (22%), Positives = 175/400 (43%), Gaps = 57/400 (14%)
Query: 220 KNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIA 279
K E + K+ Q+ + + + E +LN V L + V+S+ T ++ E A
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----TGMLNE---A 1306
Query: 280 KNNIIKLQEE----NHQLRSENKLILMKTQQHLEVT---------KVDVETELQTYKHSR 326
+ IKL ++ + QL+ +L+ +T+Q L V+ + ++ +L ++
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 327 QGLDEMYNEARRQLRDESQLRQDV--------------ENELAVQVSMKHEIELAMKLLE 372
Q L+ + QL D + QD + E+ E A LE
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 373 KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMR 432
K + Q L L L+ + + + +K + + L E+ I ++ ++ ++ A R
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 433 QLEQR---LQQAEKAQMEAEDEDEKY-------LQECLSKSDSLQKQISQKEKQLVQLET 482
+ E + L +A + +EA++E E+ +++ +S D + K + + EK LET
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 483 DLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDE-----NQQLKKIYH 537
++ K + L+++LQ +DA L Q + + L +DE +QL++ H
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 538 EQEQALQELGNK---LSESKLKIE-DIK----EANKALQG 569
E E L++ + + +K K+E D+K +A+ A++G
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Score = 61.2 bits (147), Expect = 3e-09
Identities = 81/376 (21%), Positives = 154/376 (40%), Gaps = 36/376 (9%)
Query: 207 DSQVGVIDFSMYLKNEEDIGNKERNVQIAAILD---QKNYVEELNRQLNSTVSSLHSRVD 263
D Q + + M L +E+ E +A + D QKN + R+L +S L +D
Sbjct: 1080 DLQAQIAELKMQLAKKEE----ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 264 SLEKSNTKLIEELAIAKNNIIKLQEENHQLRSE--NKLILMKTQQHLEVTKVDVETELQT 321
S + K A+ L EE L++E + L TQQ L + T L
Sbjct: 1136 SERAARNK-------AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL-- 1186
Query: 322 YKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM----KHEIELAMKLLEKDIHE 377
++ LDE Q+++ Q EL Q+ K ++ + LEK+ +
Sbjct: 1187 ----KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242
Query: 378 KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR 437
L L Q +EV+ ++ ++Q + + A L +K +K+ + +
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 438 LQQAE-KAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQE 496
L +AE KA A+D + S+ Q+ + ++ +Q + + T L+ +E R +LQ+
Sbjct: 1303 LNEAEGKAIKLAKD-----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1357
Query: 497 DLQKEKDALSHLRNETQ----QIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSE 552
L +E +A +L Q+ KK+ + + L++ ++ ++ L + E
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 553 SKLKIEDIKEANKALQ 568
+ +++ LQ
Sbjct: 1418 KAAAYDKLEKTKNRLQ 1433
Score = 58.2 bits (139), Expect = 2e-08
Identities = 75/411 (18%), Positives = 173/411 (42%), Gaps = 59/411 (14%)
Query: 219 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLH---SRVDSLEKSNTKLIEE 275
L+ E + + + ++ A + + ++ LN QL+ + L S V++LE+ + +E
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 276 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKH---SRQGLDEM 332
+ N+ + EE + + + QQ L+ VD++ + Q + ++ D++
Sbjct: 1408 I----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463
Query: 333 YNE--------------ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLE------ 372
E A + R++ + L + K E+E K+L+
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 373 --------KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKE------------ 412
K++HE + + L Q+EE+K E+ +LQ +ED
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 413 KNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQME------AEDEDEKYLQECLSKSDSL 466
+ ++ AR E+ K RQL + + E + + A+ + E L++ ++DS
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 467 QKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQ 526
K + KQL +L+ +K ++++ L++ + + + ++ SL+ + + LQ
Sbjct: 1644 IKGREEAIKQLRKLQAQMK---DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 527 DENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKE 577
++ ++ + + +EL +L+ S +++ + L+ + ++E
Sbjct: 1701 EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Score = 57.4 bits (137), Expect = 4e-08
Identities = 81/426 (19%), Positives = 174/426 (40%), Gaps = 71/426 (16%)
Query: 213 IDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKL 272
++ ++ K E + NK ++ ++ K+ V + +L + +L ++++ ++ +L
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 273 IEELAIAKNNIIKLQ------------------EENHQLRSENKLILMKTQQHLE----- 309
+EL ++ ++L+ E+N + R + + L + + LE
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 310 -----VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEI 364
K +E +L+ + + EA +QLR +D + EL + + EI
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 365 -------ELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLK----EK 413
E K LE D+ + Q+ L + ++ E+ ++L S G EK
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 414 NEIIAR-------LEEKTNKITAAMRQLEQRLQQAEKAQME-------------AEDEDE 453
+ AR LEE+ + A ++ + QQAE+ E A + E
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 454 KYLQECLSKSDSLQKQISQK--------EKQLVQLETDLKIEKEWRQTLQEDLQKE---- 501
+ +E SK ++ + K E ++ QLE ++ E +Q + L+++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 502 KDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIK 561
K+ L + +E + K++ +QLK+ E E+ Q + + + ++++
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918
Query: 562 EANKAL 567
E+N+A+
Sbjct: 1919 ESNEAM 1924
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 82.0 bits (201), Expect = 2e-15
Identities = 72/347 (20%), Positives = 158/347 (45%), Gaps = 26/347 (7%)
Query: 250 QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLE 309
Q+ + ++ D L+K+ E A+N + +L++++ QL E L+ + Q E
Sbjct: 846 QVTRQEEEMQAKEDELQKTK----ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 310 VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQ--------------DVENELA 355
+ E ++ +Q L+E+ +E +L +E Q D+E +L
Sbjct: 902 LYAEAEEMRVRLAA-KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 356 VQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNE 415
+ + + +++L E I + +D ++ + Q ++ + +++ L E+ E
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 416 IIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEK 475
L + NK + + +LE RL++ EK++ E EK ++ + +QI+ +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQEL----EKLKRKLEGDASDFHEQIADLQA 1076
Query: 476 QLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKI 535
Q+ +L+ L ++E LQ L + D ++ N ++I L+ +LQ++ +
Sbjct: 1077 QIAELKMQLAKKEE---ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 536 YHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
++ E+ ++LG +L K ++ED ++ Q L +++E T K
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Score = 71.6 bits (174), Expect = 2e-12
Identities = 72/315 (22%), Positives = 139/315 (44%), Gaps = 38/315 (12%)
Query: 287 QEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 346
QEE Q + + L KT++ + E EL+ + L E N + QL+ E++L
Sbjct: 850 QEEEMQAKEDE---LQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 347 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDT--------------LIGLRQQLEEV 392
+ E + K E+E + +E + E++D ++ L +QLEE
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 393 KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDED 452
+A ++ + +E +K+ + I ++++ NK++ + LE+R+ E E+
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE-- 1020
Query: 453 EKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNET 512
K+ +L K ++ E + +LE LK E++ RQ L++ +K + S
Sbjct: 1021 ---------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH--- 1068
Query: 513 QQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVW 572
+QI L+ + L+ QL K E + AL L +++++ ++ I+E + L
Sbjct: 1069 EQIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 573 LKDKEATHCKLCEKE 587
D E EK+
Sbjct: 1126 DLDSERAARNKAEKQ 1140
Score = 71.2 bits (173), Expect = 3e-12
Identities = 88/400 (22%), Positives = 175/400 (43%), Gaps = 57/400 (14%)
Query: 220 KNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIA 279
K E + K+ Q+ + + + E +LN V L + V+S+ T ++ E A
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----TGMLNE---A 1299
Query: 280 KNNIIKLQEE----NHQLRSENKLILMKTQQHLEVT---------KVDVETELQTYKHSR 326
+ IKL ++ + QL+ +L+ +T+Q L V+ + ++ +L ++
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 327 QGLDEMYNEARRQLRDESQLRQDV--------------ENELAVQVSMKHEIELAMKLLE 372
Q L+ + QL D + QD + E+ E A LE
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 373 KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMR 432
K + Q L L L+ + + + +K + + L E+ I ++ ++ ++ A R
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 433 QLEQR---LQQAEKAQMEAEDEDEKY-------LQECLSKSDSLQKQISQKEKQLVQLET 482
+ E + L +A + +EA++E E+ +++ +S D + K + + EK LET
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 483 DLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDE-----NQQLKKIYH 537
++ K + L+++LQ +DA L Q + + L +DE +QL++ H
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 538 EQEQALQELGNK---LSESKLKIE-DIK----EANKALQG 569
E E L++ + + +K K+E D+K +A+ A++G
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Score = 61.2 bits (147), Expect = 3e-09
Identities = 81/376 (21%), Positives = 154/376 (40%), Gaps = 36/376 (9%)
Query: 207 DSQVGVIDFSMYLKNEEDIGNKERNVQIAAILD---QKNYVEELNRQLNSTVSSLHSRVD 263
D Q + + M L +E+ E +A + D QKN + R+L +S L +D
Sbjct: 1073 DLQAQIAELKMQLAKKEE----ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 264 SLEKSNTKLIEELAIAKNNIIKLQEENHQLRSE--NKLILMKTQQHLEVTKVDVETELQT 321
S + K A+ L EE L++E + L TQQ L + T L
Sbjct: 1129 SERAARNK-------AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL-- 1179
Query: 322 YKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM----KHEIELAMKLLEKDIHE 377
++ LDE Q+++ Q EL Q+ K ++ + LEK+ +
Sbjct: 1180 ----KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235
Query: 378 KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR 437
L L Q +EV+ ++ ++Q + + A L +K +K+ + +
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 438 LQQAE-KAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQE 496
L +AE KA A+D + S+ Q+ + ++ +Q + + T L+ +E R +LQ+
Sbjct: 1296 LNEAEGKAIKLAKD-----VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD 1350
Query: 497 DLQKEKDALSHLRNETQ----QIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSE 552
L +E +A +L Q+ KK+ + + L++ ++ ++ L + E
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 553 SKLKIEDIKEANKALQ 568
+ +++ LQ
Sbjct: 1411 KAAAYDKLEKTKNRLQ 1426
Score = 58.2 bits (139), Expect = 2e-08
Identities = 75/411 (18%), Positives = 173/411 (42%), Gaps = 59/411 (14%)
Query: 219 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLH---SRVDSLEKSNTKLIEE 275
L+ E + + + ++ A + + ++ LN QL+ + L S V++LE+ + +E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 276 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKH---SRQGLDEM 332
+ N+ + EE + + + QQ L+ VD++ + Q + ++ D++
Sbjct: 1401 I----ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456
Query: 333 YNE--------------ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLE------ 372
E A + R++ + L + K E+E K+L+
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 373 --------KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKE------------ 412
K++HE + + L Q+EE+K E+ +LQ +ED
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 413 KNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQME------AEDEDEKYLQECLSKSDSL 466
+ ++ AR E+ K RQL + + E + + A+ + E L++ ++DS
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 467 QKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQ 526
K + KQL +L+ +K ++++ L++ + + + ++ SL+ + + LQ
Sbjct: 1637 IKGREEAIKQLRKLQAQMK---DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 527 DENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKE 577
++ ++ + + +EL +L+ S +++ + L+ + ++E
Sbjct: 1694 EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Score = 57.4 bits (137), Expect = 4e-08
Identities = 81/426 (19%), Positives = 174/426 (40%), Gaps = 71/426 (16%)
Query: 213 IDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKL 272
++ ++ K E + NK ++ ++ K+ V + +L + +L ++++ ++ +L
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 273 IEELAIAKNNIIKLQ------------------EENHQLRSENKLILMKTQQHLE----- 309
+EL ++ ++L+ E+N + R + + L + + LE
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 310 -----VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEI 364
K +E +L+ + + EA +QLR +D + EL + + EI
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 365 -------ELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLK----EK 413
E K LE D+ + Q+ L + ++ E+ ++L S G EK
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 414 NEIIAR-------LEEKTNKITAAMRQLEQRLQQAEKAQME-------------AEDEDE 453
+ AR LEE+ + A ++ + QQAE+ E A + E
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 454 KYLQECLSKSDSLQKQISQK--------EKQLVQLETDLKIEKEWRQTLQEDLQKE---- 501
+ +E SK ++ + K E ++ QLE ++ E +Q + L+++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 502 KDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIK 561
K+ L + +E + K++ +QLK+ E E+ Q + + + ++++
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 562 EANKAL 567
E+N+A+
Sbjct: 1912 ESNEAM 1917
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 81.3 bits (199), Expect = 3e-15
Identities = 71/342 (20%), Positives = 169/342 (49%), Gaps = 35/342 (10%)
Query: 234 IAAILDQKN----YVEELNRQLNSTVSSLHSRV---DSLEKSNTKLIEELAIAKNNIIKL 286
++A+ QK Y+EEL ++ ++ L+ + L++ N KL E+L + ++ ++
Sbjct: 169 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 228
Query: 287 QEENHQLRSE-NKLILMKTQQHLEVTKVDVETELQTYKHSRQGL---DEMYNEARRQLRD 342
Q +L+ + + L+ QQ L+ + ELQ+ Q +E++N +Q ++
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ-QE 287
Query: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
E RQ+ + ++ E+ I E+++ + +++ + + E +K
Sbjct: 288 EKMWRQEEK----------------IQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEK 331
Query: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSK 462
++ E+ + EK E I LEEK ++ Q E+R ++ + + E E E + K
Sbjct: 332 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 391
Query: 463 SDSLQKQISQKEKQLVQLETDL--KIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKK 520
+++I ++E+ + + E + + EK W Q +E++Q++++ +R + ++I +K
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQ--EEEMQEQEE---KMRRQEEKIREQEK 446
Query: 521 EFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKE 562
+ +++ ++ +++ EQE+ + E K+ E + K+++ +E
Sbjct: 447 KIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEE 488
Score = 73.2 bits (178), Expect = 7e-13
Identities = 99/461 (21%), Positives = 210/461 (45%), Gaps = 60/461 (13%)
Query: 113 VEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMAD-YLRCLIIQRDLLS-EF 170
V++L EA ++ + + D L +A L QKK AD Y+ L +RD LS E
Sbjct: 141 VKQLEGEARDLISRLHDSWKFAGELEQA---LSAVATQKKKADRYIEELTKERDALSLEL 197
Query: 171 YEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKE- 229
Y + D L K L ++ +++ K+E + KE
Sbjct: 198 YRN-------------------TITDEELKEKNAKLQEKLQLVESE---KSEIQLNVKEL 235
Query: 230 -RNVQIAAILDQKNYVE----ELNRQLNSTVSSLHSRVDSLEKSNT-------KLIEELA 277
R ++ A +L + ++ L ++L S + L ++V+ E N K+ +
Sbjct: 236 KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE 295
Query: 278 IAKNNIIKLQEENHQLRS-ENKLILMKTQQHLEVTKVDVETELQTYKHSR-QGLDEMYNE 335
+ K+QE+ ++R E K+ + + K+ + E+ K + + L+E +E
Sbjct: 296 KIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 355
Query: 336 ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI 395
+ ++R++ + RQ E E + + E E M E+ I E+++ + + ++E +
Sbjct: 356 -QEKIREQEEKRQ--EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412
Query: 396 NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR-------LQQAEKAQMEA 448
E +K+ E+ ++E+ E + R EEK + +R+ E++ +Q+ E+ E
Sbjct: 413 MGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQ 472
Query: 449 ED---EDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDAL 505
E E E +QE K +++I ++EK++ + E ++ ++E Q +E + ++++ +
Sbjct: 473 EGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 532
Query: 506 SHLRNETQQIISLKKEFLNLQDENQQLKKI-YHEQEQALQE 545
+ Q+ ++E + Q+E + +++ +QE+ +QE
Sbjct: 533 CEQEEKMQE----QEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 63.2 bits (152), Expect = 7e-10
Identities = 72/340 (21%), Positives = 169/340 (49%), Gaps = 43/340 (12%)
Query: 245 EELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRS--------- 295
E L R+L + V ++ R+ + +K T+L L +++ + +L+ E L S
Sbjct: 107 EALRRELEAQVQTI--RILTCQK--TELQMALYYSQHAVKQLEGEARDLISRLHDSWKFA 162
Query: 296 ---ENKLILMKTQQHL------EVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 346
E L + TQ+ E+TK L+ Y+++ DE E +L+++ QL
Sbjct: 163 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTIT--DEELKEKNAKLQEKLQL 220
Query: 347 RQDVENELAVQVS-MKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQG 405
+ ++E+ + V +K ++E A LL + + + +G ++L+ V A KLQ
Sbjct: 221 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG--KELQSVSA-------KLQA 271
Query: 406 SEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDS 465
+ + N + + EEK + +++ E+++Q+ E+ E E++ + + K +
Sbjct: 272 QVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEK 331
Query: 466 LQKQ---ISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEF 522
+++Q + +KE+++ +LE + +++ R+ QE+ ++E++ + +Q + ++
Sbjct: 332 MRRQEEMMWEKEEKIRELEEKMHEQEKIRE--QEEKRQEEEKIREQEKRQEQEAKMWRQE 389
Query: 523 LNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKE 562
++++ ++++ EQE+ +QE K+ E + K+ + +E
Sbjct: 390 EKIREQEEKIR----EQEEMMQEQEEKMGEQEEKMWEQEE 425
Score = 58.2 bits (139), Expect = 2e-08
Identities = 59/288 (20%), Positives = 136/288 (47%), Gaps = 31/288 (10%)
Query: 304 TQQHLEVTKVDVETELQTYK--------------HSRQGLDEMYNEAR---RQLRDESQL 346
+ QH E + ++E ++QT + +S+ + ++ EAR +L D +
Sbjct: 102 SHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKF 161
Query: 347 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGS 406
++E L+ + K + + ++ L K+ L EE+K N ++ +KLQ
Sbjct: 162 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 221
Query: 407 EDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSL 466
E EK+EI ++E K+ A L Q+ QAE + E + + + + L
Sbjct: 222 ES---EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL 278
Query: 467 QKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQ 526
+++Q++++ + + + E+E + +QE +K ++ +R + ++++ K+E + Q
Sbjct: 279 WNRLNQQQEEKMWRQEEKIQERE--EKIQEQEEKIREQEEKMRRQ-EEMMWEKEEKMRRQ 335
Query: 527 DEN--------QQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKA 566
+E ++L++ HEQE+ ++ + E K++ ++ ++ +A
Sbjct: 336 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 383
Score = 50.4 bits (119), Expect = 5e-06
Identities = 54/230 (23%), Positives = 101/230 (43%), Gaps = 13/230 (5%)
Query: 357 QVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEI 416
Q +++ E+E ++ + +K + + L VK + E + D K E+
Sbjct: 106 QEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGEL 165
Query: 417 IARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDE---DEKYLQECLSKSDSLQKQISQK 473
L + A R +E+ ++ + +E DE+ ++ + LQ S+K
Sbjct: 166 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEK 225
Query: 474 -EKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDE---- 528
E QL E K+E+ Q+ LQ E D HL E Q + S K + ++E
Sbjct: 226 SEIQLNVKELKRKLERAKLLLPQQQLQAEAD---HLGKELQSV-SAKLQAQVEENELWNR 281
Query: 529 -NQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKE 577
NQQ ++ QE+ +QE K+ E + KI + +E + + ++W K+++
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEK 331
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 81.3 bits (199), Expect = 3e-15
Identities = 87/384 (22%), Positives = 172/384 (44%), Gaps = 31/384 (8%)
Query: 222 EEDIGNKERNVQ--IAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTK----LIEE 275
EE G +N++ ++++ + E+ R L +S +H +DS ++S + LIEE
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEI-RDLQDQLSEMHDELDSAKRSEDREKGALIEE 731
Query: 276 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE 335
L AK ++ L + E + +L K ++ L K ++ E+ ++ L E Y+
Sbjct: 732 LLQAKQDLQDLLIA----KEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
Query: 336 ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI 395
+ LR+ + LA + + + + ++ K + E+ + L G ++LE A
Sbjct: 788 ELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQ 847
Query: 396 NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKY 455
+ L+G E A+ +E K +RQLE+ L A K + EA +
Sbjct: 848 LQRQIEDLKGDE----------AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSA-RRA 896
Query: 456 LQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEK----DALSHLRNE 511
L+ L + Q +Q++KQL + + +KE + L+ +++ E+ + L+ E
Sbjct: 897 LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKE 956
Query: 512 TQQIISLKK-EFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGL 570
I+ + L LQ+ QL + + + L E+ +L E L+ E + +Q
Sbjct: 957 MADIVEASRTSTLELQN---QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDE 1013
Query: 571 VWLKDKEATHCKLCEKEFSLSKRK 594
+ L ++E + + E +L+KR+
Sbjct: 1014 MRLMEEELRDYQRAQDE-ALTKRQ 1036
Score = 77.4 bits (189), Expect = 4e-14
Identities = 97/414 (23%), Positives = 186/414 (44%), Gaps = 60/414 (14%)
Query: 221 NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAK 280
+E+D E V++ + ++ ++ + +L V+ L +++ L+ K E L +
Sbjct: 813 SEQDQAGTEMRVKL--LQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYE 870
Query: 281 NNIIKLQEENHQLRSENKLILMKT---QQHLEVTKVDVETELQTYKHSRQGLDEMYNEAR 337
I +L+E R E K + + LE + ++ Q K + L E +E +
Sbjct: 871 GEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEE-SEQK 929
Query: 338 RQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINI 397
QLR +L+ ++ENE + + IE K + + + + + L+ QL+E K N
Sbjct: 930 EQLR---RLKNEMENE---RWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983
Query: 398 EMYQKLQGSEDGLKEKNEIIARLEEKTNKITAA-----MRQLEQRLQQAEKAQMEAEDE- 451
++Q LKEK LE + +++TA MR +E+ L+ ++AQ EA +
Sbjct: 984 RELAEMQRQ---LKEKT-----LEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKR 1035
Query: 452 --------DEKYLQECLSK-SDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEK 502
D +Y E S D + + Q E ++ QLE +L+ E+ L E + + +
Sbjct: 1036 QLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR 1095
Query: 503 DALSHLRNETQQIISLKKEF----LNLQDENQQLK-KIYH--------------EQEQAL 543
+ + LRNE Q + +++ ++L+ +N+ LK +I H + E +
Sbjct: 1096 EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARI 1155
Query: 544 QELGNKLSESKLKIEDIKEANKALQ----GLVWLKDKEATHCKLCEKEFSLSKR 593
EL ++L + +++ +N+ L+ LV D E H L +++ LS R
Sbjct: 1156 AELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDE--HLSLTDQKDQLSLR 1207
Score = 41.2 bits (95), Expect = 0.003
Identities = 83/393 (21%), Positives = 154/393 (39%), Gaps = 78/393 (19%)
Query: 85 MEHCLKHGLKVRKSFLSYNKTIWGPLE---------------LVEKLYPEAEEIGASVRD 129
+E L H K K +S + + LE L EKL E+E+
Sbjct: 876 LEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ----KEQ 931
Query: 130 LPGLKTPLGRARAWLRLAL--MQKKMADYLRC-----LIIQRDL-------LSEFYEYHA 175
L LK + R L + +QK+MAD + L +Q L E E
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 176 LMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIA 235
+ E+ L + + D + + E+L D ++ + + K+ ++
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELE 1050
Query: 236 AILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRS 295
A K+ L +Q+ VS L ++ E++N+ L+ E I + +E+ QLR+
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQLEMELEE-ERNNSDLLSE------RISRSREQMEQLRN 1103
Query: 296 ENKLILMKTQQHLEVTKVDVETELQ-----------TYKHSRQGL------------DEM 332
E L +Q LE K+ +E + + +Y+ S++GL D +
Sbjct: 1104 E-LLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRL 1162
Query: 333 YNEAR----------RQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQ--- 379
+E R R R +L V++E K ++ L +K +++ + E +
Sbjct: 1163 ESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEI 1222
Query: 380 DTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKE 412
D L +++L+ ++M + LQG + +K+
Sbjct: 1223 DRLESSKKKLQRELEEQMDMNEHLQGQLNSMKK 1255
>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
Length = 1161
Score = 80.5 bits (197), Expect = 4e-15
Identities = 42/119 (35%), Positives = 66/119 (55%), Gaps = 10/119 (8%)
Query: 530 QQLKKIYHEQEQALQELGNKLSESKLKIED-IKEANKALQG-------LVWLKDKEATHC 581
Q+L++I +Q ++ L ++ E K ++E ++ G WL D A HC
Sbjct: 1029 QRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVMTRWLPDHLAAHC 1088
Query: 582 KLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSP--KPVRVCDSCHALLIQRCSS 638
C+ F L+ RKHHCRNCG +FC++C + ++P+PS +P RVC SC++ L SS
Sbjct: 1089 YACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSS 1147
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 79.3 bits (194), Expect = 1e-14
Identities = 112/545 (20%), Positives = 226/545 (41%), Gaps = 67/545 (12%)
Query: 111 ELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQK-------------KMADYL 157
E + KL + VR+L +K L A + + M+K KMA+ L
Sbjct: 65 EQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQEQNETFQANRAKMAEGL 124
Query: 158 RCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFS- 216
+ ++D + + +E+E ++ L + NL + +++D G
Sbjct: 125 ALALARKD---QEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQEL 181
Query: 217 -----MYLKNEEDIGNKERNVQ-----IAAILDQKNYVEELNRQLNSTVSSLHSRVDSLE 266
M LK EE +G E+ ++ ++ ++ +++ L+ + L +LE
Sbjct: 182 SKIKHMLLKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLE 241
Query: 267 KSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSR 326
+ +I A++ I L+++ +L++ + Q +++ KV ET+ +
Sbjct: 242 EQRDHVIASKTGAESKITALEQKEQELQA------LIQQLSIDLQKVTAETQEKE----- 290
Query: 327 QGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLR 386
D + + + E +L Q++ E VQ +K + L E+++ + + L+ R
Sbjct: 291 ---DVITHLQEKVASLEKRLEQNLSGEEHVQELLKEKT-----LAEQNLEDTRQQLLAAR 342
Query: 387 QQLEEVKAINI------EMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQ 440
+ KAIN E+ Q LQ SE+ L++ I+A E + ++ AA ++ QQ
Sbjct: 343 SS--QAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQ 400
Query: 441 AEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQK 500
A + + + + + ++ + + E+ + QLE + KE R + LQ
Sbjct: 401 ALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQN 460
Query: 501 EKDALSHLRNE-----------TQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNK 549
+ L L+ E Q + ++K+ Q + L I E+EQ L+E
Sbjct: 461 HQFELKKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEV 520
Query: 550 LSESKLKIEDIKEA-NKALQGLVWLK-DKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNA 607
L + + +I ++ N AL + L+ + EA E+ +++++ R G + A
Sbjct: 521 LLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQAEA 580
Query: 608 CSDNE 612
S NE
Sbjct: 581 LSVNE 585
Score = 57.0 bits (136), Expect = 5e-08
Identities = 78/328 (23%), Positives = 133/328 (40%), Gaps = 71/328 (21%)
Query: 230 RNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEE 289
R+ Q AI + V EL + L ++ L + T+ I+ELA A +Q++
Sbjct: 342 RSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQ-IQELAAANQESSHVQQQ 400
Query: 290 NHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQD 349
L QQ LE T+ +E ++ + +R + RQL E+ ++
Sbjct: 401 ----------ALALEQQFLERTQA-LEAQIVALERTRAADQTTAEQGMRQLEQENAALKE 449
Query: 350 VENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK------- 402
NE + H+ EL K L+++ +++ + + Q LEEV+ E Q+
Sbjct: 450 CRNEYERSLQ-NHQFEL--KKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAI 506
Query: 403 LQGSEDGLKEKNEI-------IARLEEKTNKITAAMRQLEQRLQ-----QAEKAQMEAED 450
+ E L+EK E+ I +LE N + QL+ L+ +AE+A + AE
Sbjct: 507 IDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKAEEAAVVAEQ 566
Query: 451 EDEKYLQ-----ECLSKSDS--------------------------------LQKQISQK 473
ED L+ E LS ++S LQK+
Sbjct: 567 EDLLRLRGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQKEKQDL 626
Query: 474 EKQLVQLETDLKIEKEWRQTLQEDLQKE 501
E+QL++ +K ++ L++ LQKE
Sbjct: 627 EQQLLEKNKTIKQMQQRMLELRKTLQKE 654
Score = 40.4 bits (93), Expect = 0.005
Identities = 34/163 (20%), Positives = 78/163 (47%), Gaps = 11/163 (6%)
Query: 410 LKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQ 469
L +NE I +LE + + +R L++ ++ E A + +D + QE ++++ Q
Sbjct: 60 LLRRNEQIRKLEARLSDYAEQVRNLQKIKEKLEIALEKHQDSSMRKFQE---QNETFQAN 116
Query: 470 ISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALS----HLRNETQQIISLKKEFLNL 525
++ + L + ++EW + + + L+KEK+ L+ ++N++ + + E L
Sbjct: 117 RAKMAEGLALALA--RKDQEWSEKM-DQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDEL 173
Query: 526 QD-ENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKAL 567
+ + Q+L KI H + + LG E + + ++ + L
Sbjct: 174 EGFQQQELSKIKHMLLKKEESLGKMEQELEARTRELSRTQEEL 216
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,531,484
Number of Sequences: 37866
Number of extensions: 1048426
Number of successful extensions: 15436
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 540
Number of HSP's successfully gapped in prelim test: 1140
Number of HSP's that attempted gapping in prelim test: 5798
Number of HSP's gapped (non-prelim): 5032
length of query: 641
length of database: 18,247,518
effective HSP length: 109
effective length of query: 532
effective length of database: 14,120,124
effective search space: 7511905968
effective search space used: 7511905968
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.