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Search of human proteins with 109240552
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
(403 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 779 0.0
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 690 0.0
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 436 e-122
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 436 e-122
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 436 e-122
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 431 e-121
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 419 e-117
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 419 e-117
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 89 5e-18
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 82 7e-16
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 82 1e-15
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 69 6e-12
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 67 3e-11
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 67 3e-11
gi|71061468 centromere protein E [Homo sapiens] 65 1e-10
gi|58530840 desmoplakin isoform I [Homo sapiens] 59 1e-08
gi|16262452 cingulin [Homo sapiens] 57 3e-08
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 57 3e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 56 5e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 56 5e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 55 1e-07
gi|109134347 NY-REN-58 antigen [Homo sapiens] 55 1e-07
gi|109134355 NY-REN-58 antigen [Homo sapiens] 55 1e-07
gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens] 55 1e-07
gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens] 55 1e-07
gi|4504063 golgin 97 [Homo sapiens] 54 3e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 53 4e-07
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa... 53 4e-07
gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap... 53 4e-07
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 53 4e-07
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 779 bits (2011), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 60
MATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV
Sbjct: 1 MATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 60
Query: 61 RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLL 120
RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLL
Sbjct: 61 RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLL 120
Query: 121 VGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNR 180
VGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNR
Sbjct: 121 VGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNR 180
Query: 181 QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLE 240
QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLE
Sbjct: 181 QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLE 240
Query: 241 VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMK 300
VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMK
Sbjct: 241 VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMK 300
Query: 301 LLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITA 360
LLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITA
Sbjct: 301 LLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITA 360
Query: 361 AMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQYKLVKDISF 403
AMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQYKLVKDISF
Sbjct: 361 AMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQYKLVKDISF 403
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 690 bits (1780), Expect = 0.0
Identities = 365/401 (91%), Positives = 367/401 (91%), Gaps = 34/401 (8%)
Query: 1 MATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 60
+ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV
Sbjct: 36 LATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 95
Query: 61 RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGL---------------------- 98
RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGL
Sbjct: 96 RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMAD 155
Query: 99 ------------NEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDF 146
+EFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDF
Sbjct: 156 YLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDF 215
Query: 147 SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEE 206
SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEE
Sbjct: 216 SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEE 275
Query: 207 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE 266
LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE
Sbjct: 276 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE 335
Query: 267 ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI 326
ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI
Sbjct: 336 ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI 395
Query: 327 NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ
Sbjct: 396 NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 436
Score = 45.8 bits (107), Expect = 7e-05
Identities = 60/223 (26%), Positives = 97/223 (43%), Gaps = 35/223 (15%)
Query: 140 QVGVIDFSMY--LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLE 197
+V I+ MY L+ ED G KE+N IA + ++ N + RQL + E
Sbjct: 391 EVKAINIEMYQKLQGSED-GLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAE 449
Query: 198 KSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSR 257
+ K ++E ++K++ S K I K +Q V +ET+L+ K R
Sbjct: 450 DEDEKYLQE-CLSKSD------------SLQKQISQKEKQ-----LVQLETDLKIEKEWR 491
Query: 258 QGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHE---IELAMKLLEKDIHEKQDTLI 314
Q L E L+ E + NE +S+K E ++ + L+K HE++ L
Sbjct: 492 QTLQE-------DLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQ 544
Query: 315 GLRQQLEEVKAINIEMYQKLQGSEDG---LKEKNEIIARLEEK 354
L +L E K + IE ++ + G LK+K +L EK
Sbjct: 545 ELGNKLSESK-LKIEDIKEANKALQGLVWLKDKEATHCKLCEK 586
Score = 42.7 bits (99), Expect = 6e-04
Identities = 50/224 (22%), Positives = 104/224 (46%), Gaps = 12/224 (5%)
Query: 150 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 209
L++E + N ++A + K+ +E + L + H + D+L +L E AI
Sbjct: 340 LRDESQLRQDVEN-ELAVQVSMKHEIELAMKLLEKDI---HEKQDTLIGLRQQLEEVKAI 395
Query: 210 AKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKV--DVETELQTYKHSR---QGLDEMY 264
KLQ L+ +N++I ++ ++T +E LQ + ++ + DE Y
Sbjct: 396 NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKY 455
Query: 265 NEARRQLRDESQLRQDVENELAVQVSMKHEIELAMK-LLEKDIHEKQDTLIGLRQQLEEV 323
+ D Q + + + VQ+ +IE + L++D+ +++D L LR + +++
Sbjct: 456 LQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQI 515
Query: 324 KAINIEMYQKLQGSEDGLKE-KNEIIARLEEKTNKITAAMRQLE 366
++ E + LQ LK+ +E L+E NK++ + ++E
Sbjct: 516 ISLKKE-FLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIE 558
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 436 bits (1122), Expect = e-122
Identities = 224/400 (56%), Positives = 295/400 (73%), Gaps = 34/400 (8%)
Query: 2 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 61
A+K ERANL++M KLSIK L++SALS GR+LD+D+ PLQQFFVVMEHCLKHGLKV+
Sbjct: 104 ASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVK 163
Query: 62 KSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPG------------------------ 97
KSF+ NK+ +GPLELVEKL PEA +I SVR+LP
Sbjct: 164 KSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADY 223
Query: 98 ----------LNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFS 147
L+EFYE ALMMEEEG VIVGLLVGLNV+DANLC+KGEDLDSQVGVIDFS
Sbjct: 224 LKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFS 283
Query: 148 MYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEEL 207
+YLK+ +D+ + + +I +LDQKNYVEELNR L+ TV L +++D LEK+N+KL EEL
Sbjct: 284 LYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEEL 343
Query: 208 AIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEA 267
+ A + I LQEE QLR +N+LI ++++ +E+TK D + EL+TYK +RQGLDEMY++
Sbjct: 344 SAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDV 403
Query: 268 RRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAIN 327
+QL++E ++R ++E EL +Q+ MK E+E+AMKLLEKD HEKQDTL+ LRQQLEEVKAIN
Sbjct: 404 WKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAIN 463
Query: 328 IEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
++M+ K Q +E L++KNE I E KTN++ ++M+Q+E+
Sbjct: 464 LQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 503
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 436 bits (1120), Expect = e-122
Identities = 222/392 (56%), Positives = 292/392 (74%), Gaps = 34/392 (8%)
Query: 10 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNK 69
ERANL++M KLSIK L++SALS GR+LD+D+ PLQQFFVVMEHCLKHGLKV+KSF+ NK
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNK 63
Query: 70 TIWGPLELVEKLYPEAEEIGASVRDLPG-------------------------------- 97
+ +GPLELVEKL PEA +I SVR+LP
Sbjct: 64 SFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNK 123
Query: 98 --LNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEED 155
L+EFYE ALMMEEEG VIVGLLVGLNV+DANLC+KGEDLDSQVGVIDFS+YLK+ +D
Sbjct: 124 HLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQD 183
Query: 156 IGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNII 215
+ + + +I +LDQKNYVEELNR L+ TV L +++D LEK+N+KL EEL+ A + I
Sbjct: 184 LDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRIC 243
Query: 216 KLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDES 275
LQEE QLR +N+LI ++++ +E+TK D + EL+TYK +RQGLDEMY++ +QL++E
Sbjct: 244 SLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 303
Query: 276 QLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQ 335
++R ++E EL +Q+ MK E+E+AMKLLEKD HEKQDTL+ LRQQLEEVKAIN++M+ K Q
Sbjct: 304 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 363
Query: 336 GSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
+E L++KNE I E KTN++ ++M+Q+E+
Sbjct: 364 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 395
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 436 bits (1120), Expect = e-122
Identities = 222/392 (56%), Positives = 292/392 (74%), Gaps = 34/392 (8%)
Query: 10 ERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNK 69
ERANL++M KLSIK L++SALS GR+LD+D+ PLQQFFVVMEHCLKHGLKV+KSF+ NK
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNK 63
Query: 70 TIWGPLELVEKLYPEAEEIGASVRDLPG-------------------------------- 97
+ +GPLELVEKL PEA +I SVR+LP
Sbjct: 64 SFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNK 123
Query: 98 --LNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEED 155
L+EFYE ALMMEEEG VIVGLLVGLNV+DANLC+KGEDLDSQVGVIDFS+YLK+ +D
Sbjct: 124 HLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQD 183
Query: 156 IGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNII 215
+ + + +I +LDQKNYVEELNR L+ TV L +++D LEK+N+KL EEL+ A + I
Sbjct: 184 LDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRIC 243
Query: 216 KLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDES 275
LQEE QLR +N+LI ++++ +E+TK D + EL+TYK +RQGLDEMY++ +QL++E
Sbjct: 244 SLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 303
Query: 276 QLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQ 335
++R ++E EL +Q+ MK E+E+AMKLLEKD HEKQDTL+ LRQQLEEVKAIN++M+ K Q
Sbjct: 304 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 363
Query: 336 GSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
+E L++KNE I E KTN++ ++M+Q+E+
Sbjct: 364 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 395
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 431 bits (1107), Expect = e-121
Identities = 233/406 (57%), Positives = 291/406 (71%), Gaps = 48/406 (11%)
Query: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
Query: 68 NKTIWGPLELVEKLYPEAEEIGASVRDLPGL----------------------------- 98
NK+ WGPLELVEKL PEA EI ASV+DLPGL
Sbjct: 126 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 185
Query: 99 -----NEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 153
+EFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 245
Query: 154 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 213
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
Query: 214 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 273
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 306 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 351
Query: 274 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 333
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 352 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 411
Query: 334 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTI 379
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQS+ DL+ Q +T+
Sbjct: 412 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTL 457
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 419 bits (1077), Expect = e-117
Identities = 228/394 (57%), Positives = 282/394 (71%), Gaps = 48/394 (12%)
Query: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
Query: 68 NKTIWGPLELVEKLYPEAEEIGASVRDLPGL----------------------------- 98
NK+ WGPLELVEKL PEA EI ASV+DLPGL
Sbjct: 126 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 185
Query: 99 -----NEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 153
+EFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 245
Query: 154 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 213
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
Query: 214 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 273
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 306 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 351
Query: 274 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 333
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 352 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 411
Query: 334 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQ
Sbjct: 412 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 419 bits (1077), Expect = e-117
Identities = 228/394 (57%), Positives = 282/394 (71%), Gaps = 48/394 (12%)
Query: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 126 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 185
Query: 68 NKTIWGPLELVEKLYPEAEEIGASVRDLPGL----------------------------- 98
NK+ WGPLELVEKL PEA EI ASV+DLPGL
Sbjct: 186 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 245
Query: 99 -----NEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 153
+EFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 246 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 305
Query: 154 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 213
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 306 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 365
Query: 214 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 273
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 366 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 411
Query: 274 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 333
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 412 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 471
Query: 334 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQ
Sbjct: 472 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 89.4 bits (220), Expect = 5e-18
Identities = 99/362 (27%), Positives = 153/362 (42%), Gaps = 96/362 (26%)
Query: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
AVER NL+ + + S+K LI+ S T+D P F ++E L H LK + ++ Y
Sbjct: 30 AVERRNLITVCRFSVKTLIDR--SCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
Query: 68 NKT------------------------------------IWGPLELVEKLYPEAEEIGAS 91
W + L+EK +E I +
Sbjct: 88 ESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHL--SEYISTA 145
Query: 92 VRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLD-SQVGVIDFSMYL 150
+RD FYE A+++ EE ++ G+L+GLN ID + C+KGE LD S VID++ YL
Sbjct: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
Query: 151 K--------------------------NEEDIG-----------NKERNV--QIAAILDQ 171
K E++G NK + V + L+Q
Sbjct: 206 KYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQ 265
Query: 172 KNYVEELNR----QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEE-----NH 222
K Y+EEL R QL+ +VS + +E S+ E + I++LQ++ N+
Sbjct: 266 KGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNN 325
Query: 223 QLRSENKLILMKTQQ-----HLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 277
LRS +L T Q L+V V ++T L KH++Q ++ Y ++ QL E L
Sbjct: 326 DLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYR-KHNKQWYEKSY-QSLDQLSAEVSL 383
Query: 278 RQ 279
Q
Sbjct: 384 SQ 385
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 82.4 bits (202), Expect = 7e-16
Identities = 74/306 (24%), Positives = 133/306 (43%), Gaps = 51/306 (16%)
Query: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
AVER NL+ + + S+K LI+ S T+D P F ++E L H LK + ++ Y
Sbjct: 30 AVERRNLITVCRFSVKTLIDR--SCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
Query: 68 NKT------------------------------------IWGPLELVEKLYPEAEEIGAS 91
W + L+EK +E I +
Sbjct: 88 ESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHL--SEYISTA 145
Query: 92 VRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLD-SQVGVIDFSMYL 150
+RD FYE A+++ EE ++ G+L+GLN ID + C+KGE LD S VID++ YL
Sbjct: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
Query: 151 K---NEEDIGNKERNVQ-IAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEE 206
K + + I + E ++ + + + + E + +S ++ +++ +E+
Sbjct: 206 KYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQ 265
Query: 207 LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVE------TELQTYKHSRQGL 260
+ + + + + S+NK++L + + K++ E ELQ S Q L
Sbjct: 266 KGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLKSYQSL 325
Query: 261 DEMYNE 266
D++ E
Sbjct: 326 DQLSAE 331
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 81.6 bits (200), Expect = 1e-15
Identities = 101/379 (26%), Positives = 154/379 (40%), Gaps = 113/379 (29%)
Query: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV------- 60
AVER NL+ + + S+K LI+ S T+D P F ++E L H LK
Sbjct: 30 AVERRNLITVCRFSVKTLIDR--SCFETIDDSSPEFNNFAAILEQILSHRLKEISQSCRW 87
Query: 61 -------------------RKSFLSYNKTI---------------------------WGP 74
+SF Y + W
Sbjct: 88 LAHLQIPLQGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIR 147
Query: 75 LELVEKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKG 134
+ L+EK +E I ++RD FYE A+++ EE ++ G+L+GLN ID + C+KG
Sbjct: 148 VALMEKHL--SEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKG 205
Query: 135 EDLD-SQVGVIDFSMYLK--------------------------NEEDIG---------- 157
E LD S VID++ YLK E++G
Sbjct: 206 EGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSW 265
Query: 158 -NKERNV--QIAAILDQKNYVEELNR----QLNSTVSSLHSRVDSLEKSNTKLIEELAIA 210
NK + V + L+QK Y+EEL R QL+ +VS + +E S+ E
Sbjct: 266 FNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQL 325
Query: 211 KNNIIKLQEE-----NHQLRSENKLILMKTQQ-----HLEVTKVDVETELQTYKHSRQGL 260
+ I++LQ++ N+ LRS +L T Q L+V V ++T L KH++Q
Sbjct: 326 EYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYR-KHNKQWY 384
Query: 261 DEMYNEARRQLRDESQLRQ 279
++ Y ++ QL E L Q
Sbjct: 385 EKSY-QSLDQLSAEVSLSQ 402
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 69.3 bits (168), Expect = 6e-12
Identities = 64/269 (23%), Positives = 115/269 (42%), Gaps = 47/269 (17%)
Query: 2 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 61
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKGP 76
Query: 62 KSFLSYN--KTIWGPLELVEKLYPE--------------------------------AEE 87
S+ S + + W + L P +E
Sbjct: 77 VSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEY 136
Query: 88 IGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVG-VIDF 146
I ++RD FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD + VID+
Sbjct: 137 ITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDY 196
Query: 147 SMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEK----- 198
+ YLK + + + ++E + + N E L + S +S+ +E+
Sbjct: 197 TPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIV 256
Query: 199 -SNTKLIEELAIAKNNIIK-LQEENHQLR 225
+ +EEL + + +K L+ EN +L+
Sbjct: 257 YAQKGYLEELVRLRESQLKDLEAENRRLQ 285
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/276 (23%), Positives = 117/276 (42%), Gaps = 56/276 (20%)
Query: 2 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV- 60
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKAC 76
Query: 61 -------------RKSFLSYNKTI---------------------------WGPLELVEK 80
++ F Y + W + L+EK
Sbjct: 77 APAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEK 136
Query: 81 LYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQ 140
+E I ++RD FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD +
Sbjct: 137 RM--SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGK 194
Query: 141 VG-VIDFSMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL 196
VID++ YLK + + + ++E + + N E L + S +S+ +
Sbjct: 195 TPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKM 254
Query: 197 EK------SNTKLIEELAIAKNNIIK-LQEENHQLR 225
E+ + +EEL + + +K L+ EN +L+
Sbjct: 255 EQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQ 290
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/276 (23%), Positives = 117/276 (42%), Gaps = 56/276 (20%)
Query: 2 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV- 60
A+ AVER NL+ + + S+K L+E + +D F ++E L H K
Sbjct: 19 ASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHRFKAC 76
Query: 61 -------------RKSFLSYNKTI---------------------------WGPLELVEK 80
++ F Y + W + L+EK
Sbjct: 77 APAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEK 136
Query: 81 LYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQ 140
+E I ++RD FY+ A+M+ +E ++ G+L+GL+ ID + C+KGE LD +
Sbjct: 137 RM--SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGK 194
Query: 141 VG-VIDFSMYLK---NEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL 196
VID++ YLK + + + ++E + + N E L + S +S+ +
Sbjct: 195 TPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKM 254
Query: 197 EK------SNTKLIEELAIAKNNIIK-LQEENHQLR 225
E+ + +EEL + + +K L+ EN +L+
Sbjct: 255 EQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQ 290
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 64.7 bits (156), Expect = 1e-10
Identities = 65/264 (24%), Positives = 127/264 (48%), Gaps = 38/264 (14%)
Query: 136 DLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDS 195
DL+ Q + M+LK ++ +K R + V E ++++ L D+
Sbjct: 1716 DLEKQEELKIVHMHLKEHQETIDKLRGI-----------VSEKTNEISNMQKDLEHSNDA 1764
Query: 196 LEKSNTKLIEELAIAKNNIIKLQEENHQLR---SENKLILMKTQQHLEVTKVDVETELQT 252
L+ + K+ EEL IA ++ + QE +LR SE L Q+ LE + ++ ++Q
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824
Query: 253 YK---HSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHE-IELAMKLLE----- 303
K H L + NE ++++ + QL++ ++++ ++ E + LA KL E
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
Query: 304 KDIHEKQDTL-----------IGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARL- 351
K + +++D L L++ L+E KA ++E+ Q+L+ + KE E + +L
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
Query: 352 ---EEKTNKITAAMRQLEQSDNDL 372
EKT +I+ + L++S ++L
Sbjct: 1945 EKISEKTIQISDIQKDLDKSKDEL 1968
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/292 (22%), Positives = 139/292 (47%), Gaps = 43/292 (14%)
Query: 128 ANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVS 187
+N +K +DL Q + M+LK +++ +K R + + ++ + + + + L ++ +
Sbjct: 1761 SNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGI----VSEKTDKLSNMQKDLENSNA 1816
Query: 188 SLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVE 247
L ++ L+ + +LI L N K E QL+ + K Q L ++K+++E
Sbjct: 1817 KLQEKIQELKANEHQLIT-LKKDVNETQKKVSEMEQLKKQIK------DQSLTLSKLEIE 1869
Query: 248 TELQTYKHSRQGLDEMYN--EARRQLR--------DESQLRQDVENELAVQVSMKHEIEL 297
L + + L+EM + + R LR + QL++ ++ A + ++ E++
Sbjct: 1870 N-LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKT 1928
Query: 298 AMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK-LQGSEDGLK------EKNEI-IA 349
A ++L K E ++T+ LR+++ E K I I QK L S+D L+ +K E+ +
Sbjct: 1929 A-RMLSK---EHKETVDKLREKISE-KTIQISDIQKDLDKSKDELQKKIQELQKKELQLL 1983
Query: 350 RLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQYKLVKDI 401
R++E N + ++EQ + + ++M V+ D ++L K +
Sbjct: 1984 RVKEDVNMSHKKINEMEQLKKQF--EAQNLSMQSVR------MDNFQLTKKL 2027
Score = 48.9 bits (115), Expect = 8e-06
Identities = 61/339 (17%), Positives = 157/339 (46%), Gaps = 36/339 (10%)
Query: 79 EKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLD 138
E+L E EE+ +++ L+EF +++ ++ + L + + V +DL+
Sbjct: 515 EQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574
Query: 139 SQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEK 198
+++ E + KE ++ + Y++ +++L + L ++S+E
Sbjct: 575 NELS--------SKVELLREKEDQIK-----KLQEYID--SQKLENIKMDLSYSLESIED 619
Query: 199 SNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQ 258
++ + L A+ + + E+ LRSEN L L + + L T +E ++Q Y+ +
Sbjct: 620 PK-QMKQTLFDAETVALDAKRESAFLRSEN-LELKEKMKELATTYKQMENDIQLYQSQLE 677
Query: 259 GLDEMYNEARRQLRDE----SQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLI 314
+M + ++L+ ++L ++ ++ + E+E + L+K+++++ +
Sbjct: 678 AKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENE 737
Query: 315 GLRQQ---LEEVKAINIE---MYQKLQGSEDGL----KEKNEIIARLEEKTNKITAAMRQ 364
LR++ L E+K++ E + +++Q + L EK+++ + + K +++ + +
Sbjct: 738 ALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEE 797
Query: 365 LEQSDNDLLT-----QTRTIAMSLVKCASSDTQDQYKLV 398
+ ++ +DL T ++ K D + +YK+V
Sbjct: 798 IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMV 836
Score = 47.8 bits (112), Expect = 2e-05
Identities = 52/234 (22%), Positives = 96/234 (41%), Gaps = 26/234 (11%)
Query: 160 ERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQE 219
E ++ +I ++ ++EL + + L + +E + + EEL IA ++ + QE
Sbjct: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
Query: 220 ENHQLR---SENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQ 276
+LR SE ++ TQ LE + ++ E+ H Q L E ++
Sbjct: 1250 TIDELRRSVSEKTAQIINTQD-LEKSHTKLQEEIPVL-HEEQELLPNVKEVSETQETMNE 1307
Query: 277 LRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQG 336
L E + IE+ L + E Q+ + L ++ + +K I + L+
Sbjct: 1308 LELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIK----EALEV 1363
Query: 337 SEDGLKEK-NEIIARLEE----------------KTNKITAAMRQLEQSDNDLL 373
D LKE E +A+++E +T KI + M Q + D+ LL
Sbjct: 1364 KHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417
Score = 46.2 bits (108), Expect = 5e-05
Identities = 51/287 (17%), Positives = 130/287 (45%), Gaps = 23/287 (8%)
Query: 135 EDLDSQVGVIDFSMYLKNEE-DIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRV 193
+ L S+V + + K+EE I E++ + ++ +++ V+ L ++ T L +
Sbjct: 750 KSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQ 809
Query: 194 DSLEKSNTKL--IEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQ 251
+ + ++ + + L + K+ E ++ ++ + L K Q + + ++TEL
Sbjct: 810 SNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS 869
Query: 252 TYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHE--- 308
+ Q L E E + +L + QL++ +EN + +++ E L + L++ + E
Sbjct: 870 ---YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT 926
Query: 309 ---KQDTLIGLRQQLE-----------EVKAINIEMYQKLQGSEDGLKEKNEIIARLEEK 354
++D L L++ L+ + +NI+ ++L+ + + LK+ E I L+ K
Sbjct: 927 LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSK 986
Query: 355 TNKITAAMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQYKLVKDI 401
++ + +E++ + + + + + K + ++ L D+
Sbjct: 987 ISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV 1033
Score = 45.8 bits (107), Expect = 7e-05
Identities = 48/236 (20%), Positives = 106/236 (44%), Gaps = 24/236 (10%)
Query: 164 QIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQ 223
+++ + N +E L Q + S+ +R+ E +L E+ ++ I L +E
Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARI---EMERLRLNEKFQESQEEIKSLTKERDN 1353
Query: 224 LRSENKLILMKTQQ---HLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQD 280
L++ + + +K Q H+ T ++ E Q+ + + E NE + + + Q +
Sbjct: 1354 LKTIKEALEVKHDQLKEHIRETLAKIQ-ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 281 VENELAVQVSM---------KHEIELAMKLLEKDIHEKQDTLIG----LRQQLEEVKAIN 327
L +++ M H+ ++ + D+ Q+ L L++ ++E+ A +
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 328 IEMYQKLQGSEDGLKEK----NEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTI 379
+E ++L+ + LKE+ NE+ L EK +I+ +QLE ++ L + + I
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI 1528
Score = 45.4 bits (106), Expect = 9e-05
Identities = 47/245 (19%), Positives = 111/245 (45%), Gaps = 19/245 (7%)
Query: 150 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 209
LK ++ ER+ + I D N + QL + + SL +++ +K+ EE +
Sbjct: 934 LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEE--V 991
Query: 210 AKNNIIKLQEENHQLRSE--NKLILMKTQQHLEVTKVDVET------ELQTYKHSRQGLD 261
++N + ++E + + E K++ + +Q LE T E+ + L
Sbjct: 992 SRN--LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLI 1049
Query: 262 EMYNEARRQLR----DESQLRQDVENELAVQVSMKHEIELAMKLLEKD---IHEKQDTLI 314
+ NE ++ L ++ QL+ D++ + + + + E+ L L+K + ++++ I
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAI 1109
Query: 315 GLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLT 374
+L E+ +KL+ L+EK + + ++E+ +++ + ++E N+L
Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKN 1169
Query: 375 QTRTI 379
+ T+
Sbjct: 1170 KELTL 1174
Score = 44.7 bits (104), Expect = 2e-04
Identities = 79/372 (21%), Positives = 162/372 (43%), Gaps = 40/372 (10%)
Query: 54 LKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEG 113
LK+ LK ++ L + +T LEL +KL EE+ + ++ L E + +
Sbjct: 1163 LKNELKNKELTLEHMET--ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR 1220
Query: 114 AVI-----VGLLVG--LNVIDANLCVKGEDLDS-QVGVIDFSMYLKNEEDIGNKERNVQ- 164
I GL L + +L E +D + V + + + N +D+ +Q
Sbjct: 1221 GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
Query: 165 -IAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQ 223
I + +++ + + ++++ T +++ E+S TK LA + ++L E+ +
Sbjct: 1281 EIPVLHEEQELLPNV-KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQE 1339
Query: 224 LRSENKLILMKTQQHLEVTKVDVETELQTYK-HSRQGLDEMYNEARRQLRDESQLRQDVE 282
+ E K L K + +L+ K +E + K H R+ L ++ +Q ++S ++ +
Sbjct: 1340 SQEEIKS-LTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQ--EQSLNMKEKD 1396
Query: 283 NELAVQVSMKHE----------IELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQ 332
NE VS + IE+ M L K + E D + + ++ ++++ + +
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ----E 1452
Query: 333 KLQGSEDGLKEK-NEIIAR---LEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSLVKCAS 388
LQ D LKE EI+A+ EE+ +++ E++ N+L + +S +
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL-----RVNLSEKETEI 1507
Query: 389 SDTQDQYKLVKD 400
S Q Q + + D
Sbjct: 1508 STIQKQLEAIND 1519
Score = 39.3 bits (90), Expect = 0.006
Identities = 42/222 (18%), Positives = 96/222 (43%), Gaps = 25/222 (11%)
Query: 175 VEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMK 234
+E L Q + +L +++E N +L + L + + +E LRS + + ++
Sbjct: 1646 IEHLKEQFETQKLNL----ENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701
Query: 235 TQQHLEVTKVDVETELQTY----------KHSRQGLDEMYNEARRQLRDESQLRQDVENE 284
Q E + + +L+ K ++ +D++ + + S +++D+E+
Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761
Query: 285 LAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEK 344
+ +I+ +++ + E+Q+T +++++ I E KL + L+
Sbjct: 1762 NDALKAQDLKIQEELRIAHMHLKEQQET-------IDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 345 NEIIARLEEKTNKITAAMRQLEQSDNDL-LTQTRTIAMSLVK 385
N A+L+EK ++ A QL D+ TQ + M +K
Sbjct: 1815 N---AKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853
Score = 39.3 bits (90), Expect = 0.006
Identities = 57/296 (19%), Positives = 128/296 (43%), Gaps = 40/296 (13%)
Query: 135 EDLDSQVGVIDFSMYLKNEEDIGNKE-RNVQIAAILDQKNYVEELNRQLNST----VSSL 189
++++ Q ++ +L+ + D+ ++E R++++ +D ++EE+ + + + + +
Sbjct: 2200 DEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL--HIEEILKDFSESEFPSIKTE 2257
Query: 190 HSRVDSLEKSNTKLIEELAIAKNNIIKL----QEENHQLRSENK------LILMKTQQHL 239
+V S K T+ +EE + +I KL Q+EN ++ N + +M
Sbjct: 2258 FQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEF 2317
Query: 240 EVTKVDV----ETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEI 295
E + E +L++ K + L + Y + L +Q+ ++ V+ +
Sbjct: 2318 EERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQ 2377
Query: 296 ELAMKL--LEKDIHE-------KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNE 346
K+ LE +HE K+ +I ++++LE I ++ K+ S L++ E
Sbjct: 2378 LTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKE 2437
Query: 347 IIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQYKLVKDIS 402
I L++ K+ + ++ DL M LVK ++ + K+IS
Sbjct: 2438 TIQVLQD---KVALGAKPYKEEIEDL-------KMKLVKIDLEKMKNAKEFEKEIS 2483
Score = 38.5 bits (88), Expect = 0.011
Identities = 42/182 (23%), Positives = 80/182 (43%), Gaps = 32/182 (17%)
Query: 160 ERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELA--------IAK 211
E+ +I +++ +KN EL + L S ++ L+++ IE + K
Sbjct: 1040 EQQRKIFSLIQEKN---ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096
Query: 212 NNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGL---DEMYNEAR 268
I QE+NH ++ E +L +T L + ++ + Q + +Q L E +E +
Sbjct: 1097 QQEIVAQEKNHAIKKEGEL--SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 269 RQLRDESQLRQDVEN-ELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAIN 327
+++ + L+ +++N EL ++ +ELA KL E EEVK+I
Sbjct: 1155 KKINEIENLKNELKNKELTLEHMETERLELAQKLNEN---------------YEEVKSIT 1199
Query: 328 IE 329
E
Sbjct: 1200 KE 1201
Score = 38.1 bits (87), Expect = 0.014
Identities = 46/216 (21%), Positives = 98/216 (45%), Gaps = 18/216 (8%)
Query: 173 NYVEELNRQLNSTVSSLHSRVDSLEKSN----TKLIEELAIAKN-NIIKLQEEN-----H 222
N + E++ + S + +D+L + TKL+ + I N ++ +N
Sbjct: 456 NLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYE 515
Query: 223 QLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVE 282
QLR+E + + +K ++ ++ + + E +T K L + + ++ QD+E
Sbjct: 516 QLRTEKEEMELKLKEKNDLDEFEA-LERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574
Query: 283 NELAVQVSMKHEIELAMKLLEK--DIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDG 340
NEL+ +V + E E +K L++ D + ++ + L LE ++ +M Q L +E
Sbjct: 575 NELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPK-QMKQTLFDAETV 633
Query: 341 LKEKNEIIARLEEKTNKITAAMRQL----EQSDNDL 372
+ A L + ++ M++L +Q +ND+
Sbjct: 634 ALDAKRESAFLRSENLELKEKMKELATTYKQMENDI 669
Score = 35.4 bits (80), Expect = 0.092
Identities = 42/199 (21%), Positives = 88/199 (44%), Gaps = 10/199 (5%)
Query: 187 SSLHSRVDSLEKSNTKLIE---ELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTK 243
+SLH +S +K+I+ EL + + I KLQ + H E+ L KT++ ++V +
Sbjct: 2388 NSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVH----ESNKCLEKTKETIQVLQ 2443
Query: 244 VDVETELQTYKHSRQGLD-EMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLL 302
V + YK + L ++ ++++ + +++ A K I L + L
Sbjct: 2444 DKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENL 2503
Query: 303 EKDIHEKQDTLIGLRQQLEEV-KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAA 361
+ + ++I + K + + + L K+E I RLE++ +K+
Sbjct: 2504 RRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHI-RLEKEISKLKQQ 2562
Query: 362 MRQLEQSDNDLLTQTRTIA 380
QL + N+LL+ + ++
Sbjct: 2563 NEQLIKQKNELLSNNQHLS 2581
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 58.5 bits (140), Expect = 1e-08
Identities = 51/249 (20%), Positives = 113/249 (45%), Gaps = 31/249 (12%)
Query: 161 RNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEE 220
RN I K ++E++ Q +L +++D L + N L +E+ ++I++ E+
Sbjct: 1207 RNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQ 1266
Query: 221 NHQLRSENKLI-------LMKTQQHLEVT-KVDVETELQTYKHSRQGLDEM--------- 263
+ EN L +M+ +QHLE+ K ++ + +Q L+E
Sbjct: 1267 RRRAE-ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNK 1325
Query: 264 -YNEARRQLRDESQLRQDVENELAVQ--------VSMKHEIELAMKLLEKDIH----EKQ 310
+ + ++E++ R + ENEL+ +S+K++ E + + + IH +K+
Sbjct: 1326 EIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKE 1385
Query: 311 DTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDN 370
+ G R Q++ + N + ++++ ++ L + E + R+EE + A ++ Q
Sbjct: 1386 EDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQ 1445
Query: 371 DLLTQTRTI 379
L + R +
Sbjct: 1446 QLEVELRQV 1454
Score = 45.1 bits (105), Expect = 1e-04
Identities = 54/271 (19%), Positives = 106/271 (39%), Gaps = 48/271 (17%)
Query: 150 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQL--------------NSTVSSLHSRVDS 195
++ EE + K+ A + KN E +QL N+ + + +
Sbjct: 1457 MRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQK 1516
Query: 196 LEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLI------LMKTQQHLEVTKVDVETE 249
S T+ I +L + + + +L+ + ++ E + + + L++ K VE E
Sbjct: 1517 ANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEE 1576
Query: 250 LQTYKHS-------RQGLDEMYNEARRQLRDES----QLRQDVENELAVQVSMKHEIELA 298
L K + R+ L+E RR L++++ L Q +E V+ + ++
Sbjct: 1577 LNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQ 1636
Query: 299 MKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK-----------------LQGSEDGL 341
+L+ + EKQ T LR+ EV+A+ ++ Q+ ++ L
Sbjct: 1637 RDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSL 1696
Query: 342 KEKNEIIARLEEKTNKITAAMRQLEQSDNDL 372
E I RL+ T +T LE+ +L
Sbjct: 1697 NESKIEIERLQSLTENLTKEHLMLEEELRNL 1727
Score = 44.3 bits (103), Expect = 2e-04
Identities = 45/213 (21%), Positives = 100/213 (46%), Gaps = 18/213 (8%)
Query: 172 KNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKN-------NIIKLQEENHQL 224
K + +L Q S +++D+L + N L EE+ KN N+ +++E+ Q
Sbjct: 1374 KTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQ 1433
Query: 225 RSENKLILMKTQQHLEVTKVDVETELQTYKHSR--QGLDEMYNEARRQLRDESQLRQDVE 282
++ + + QQ LEV V T+++T + R Q LD+ + + ++ +L+Q ++
Sbjct: 1434 KATGSEVSQRKQQ-LEVELRQV-TQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLID 1491
Query: 283 NELAVQVSMKHE---IELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSED 339
E + ++ E ++ L+K +T+ L+ Q +E+ + I+ Y+++
Sbjct: 1492 KETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRID-YERVSQER- 1549
Query: 340 GLKEKNEIIARLEEKTNKITAAMRQLEQSDNDL 372
K++ I R + ++ +++E+ N L
Sbjct: 1550 --TVKDQDITRFQNSLKELQLQKQKVEEELNRL 1580
Score = 35.8 bits (81), Expect = 0.071
Identities = 39/231 (16%), Positives = 96/231 (41%), Gaps = 22/231 (9%)
Query: 164 QIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQ 223
++A++ + K E + + + ++ L + T+L E+ K +++ Q
Sbjct: 1075 KLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQ 1134
Query: 224 LRSENKLILMKTQ---QHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQD 280
+++ + Q ++L K++ E ++ ++ + L R L++E +++
Sbjct: 1135 QKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERL-------RVLLQEEGTRKRE 1187
Query: 281 VENELA------------VQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINI 328
ENELA ++ + EI + +++ +K+D LR QL+ + N
Sbjct: 1188 YENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENR 1247
Query: 329 EMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTI 379
++ ++ D + + E R EE + A ++ Q L + + +
Sbjct: 1248 DLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQV 1298
Score = 35.8 bits (81), Expect = 0.071
Identities = 42/182 (23%), Positives = 76/182 (41%), Gaps = 6/182 (3%)
Query: 176 EELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKT 235
E L Q + ++ + +E+ L EE + +L + + E + K
Sbjct: 1151 ENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKY 1210
Query: 236 QQHLEVTKVDV-ETELQTY---KHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSM 291
+ + +TK + E +Q K+ R LD + E R L+DE D + Q
Sbjct: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRE-NRDLKDEIVRLNDSILQATEQRRR 1269
Query: 292 KHEIELAMKLLEKDIHEKQDTL-IGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIAR 350
E L K +I +K+ L I L+Q +++ N Q L+ + +++KN+ I R
Sbjct: 1270 AEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
Query: 351 LE 352
L+
Sbjct: 1330 LK 1331
Score = 30.0 bits (66), Expect = 3.9
Identities = 44/226 (19%), Positives = 91/226 (40%), Gaps = 19/226 (8%)
Query: 171 QKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKL 230
QK VEE +L T S + LE+ + L K IK+ QL + +
Sbjct: 1569 QKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSL---KEQAIKITNLTQQLEQAS-I 1624
Query: 231 ILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVS 290
+ +++ L + ++ L+ + +++ L + +E R QL Q+ E+ +
Sbjct: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRR---QLLQEQESVKQAHLR 1681
Query: 291 MKHEIELAMKLLEKDIHEKQ---DTLIGLRQQL--------EEVKAINIEMYQKLQGSED 339
+H + A++ + ++E + + L L + L EE++ + +E +G +
Sbjct: 1682 NEH-FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740
Query: 340 GLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSLVK 385
+KN I L + +L+ NDL + + + K
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEK 1786
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 57.0 bits (136), Expect = 3e-08
Identities = 51/236 (21%), Positives = 109/236 (46%), Gaps = 25/236 (10%)
Query: 147 SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKS--NTKLI 204
SM+ KN+ED+ ++ +L + EE+ +L + L ++ S +T+ +
Sbjct: 573 SMFQKNKEDLRATKQE-----LLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQV 627
Query: 205 EELAIAKNNIIKLQEENHQLRSENKLILM-------KTQQHLEVTKVDVETELQTYKHSR 257
E L K +++ QEE +L++E + + + ++ L V +V+ + + + +
Sbjct: 628 EVL---KKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNL 684
Query: 258 QGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLR 317
Q L + + R+ + S+ + E E V + +E ++ +++ E + ++GL
Sbjct: 685 Q-LQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLE 743
Query: 318 QQLEEVK-------AINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLE 366
QQL+E + A+ + KLQ E ++ E + +E+ + AA R LE
Sbjct: 744 QQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
Score = 44.3 bits (103), Expect = 2e-04
Identities = 65/321 (20%), Positives = 143/321 (44%), Gaps = 19/321 (5%)
Query: 88 IGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFS 147
+ ++R+ N+ + L +E++ GL+ G ++A L K + L+++ ++ +
Sbjct: 721 VETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEA 780
Query: 148 MYLKNEEDIGNKERNVQIAAILDQKN----YVEELNRQLNSTVSSLHSRVDSLEKSNTKL 203
+ EE+ + A L++ + + + LN + + + L + +L
Sbjct: 781 LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAEL 840
Query: 204 IEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEM 263
E+ + + +L +E ++ ++K L + Q LE K E+ + RQ D
Sbjct: 841 EEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQ--RQAKD-W 897
Query: 264 YNEARRQLRDESQLRQDVEN-ELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEE 322
+EA + S+L+ +++ A+Q S + E L+K++ ++ L GL Q+ E
Sbjct: 898 ASEAEKTSGGLSRLQDEIQRLRQALQAS---QAERDTARLDKELLAQR--LQGLEQEAEN 952
Query: 323 VKAINIEMYQKLQGSEDGLK----EKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRT 378
K + ++L+G E+ + E +E +E T+++ Q++Q +L+ Q R+
Sbjct: 953 KKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELM-QERS 1011
Query: 379 IAMSLVKCASSDTQDQYKLVK 399
L +C + Q K +K
Sbjct: 1012 ARQDL-ECDKISLERQNKDLK 1031
Score = 40.0 bits (92), Expect = 0.004
Identities = 58/255 (22%), Positives = 101/255 (39%), Gaps = 44/255 (17%)
Query: 132 VKGEDLDSQVGVIDFSMYLKNEEDIG---NKERNVQIAAI---LDQKNYVEELNRQLNST 185
+K E L +Q + + +++E G ++E Q+A + D+ +EE N QL T
Sbjct: 630 LKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKT 689
Query: 186 VSSLHSRVDSLEKSNTKLIEEL---------AIAKNNIIKLQEEN-----------HQLR 225
+ L R D E S K++ E A + + + QEEN QL+
Sbjct: 690 LQQL--RQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLK 747
Query: 226 SENKLI---------LMKTQQHLEVTKVDVETELQTYKH-------SRQGLDEMYNEARR 269
L+ L Q LE K +E L + +++ L+ EA+R
Sbjct: 748 ETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQR 807
Query: 270 QLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIE 329
L Q +Q + L + + + LE+ T+ L ++LE++ + +
Sbjct: 808 GLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQ 867
Query: 330 MYQKLQGSEDGLKEK 344
Q+LQ + KEK
Sbjct: 868 ALQQLQAQLEDYKEK 882
Score = 29.3 bits (64), Expect = 6.6
Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 3/71 (4%)
Query: 159 KERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQ 218
KE ++QI D++ +V + QL+ V +L +VD E+ +L A+ + +
Sbjct: 1083 KELSIQIE---DERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQH 1139
Query: 219 EENHQLRSENK 229
E N QL++ K
Sbjct: 1140 EVNEQLQARIK 1150
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 57.0 bits (136), Expect = 3e-08
Identities = 57/257 (22%), Positives = 116/257 (45%), Gaps = 30/257 (11%)
Query: 164 QIAAILDQKNYVEELN-------RQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIK 216
+I + ++ EE+N R+L S L +D LE + K+ +E +N +
Sbjct: 922 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 981
Query: 217 LQEENH-------QLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARR 269
L EE +L E K + QQ L+ + + E ++ T ++ L++ ++
Sbjct: 982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE-EDKVNTLTKAKIKLEQQVDDLEG 1040
Query: 270 QLRDESQLRQDVEN-------ELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEE 322
L E ++R D+E +L + +IE + L++ + +K+ + GL+ ++E+
Sbjct: 1041 SLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIED 1100
Query: 323 VKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMS 382
+A+ +++ +K +KE I LEE+ A+ + E+ +DL + I+
Sbjct: 1101 EQALGMQLQKK-------IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 383 LVKCASSDTQDQYKLVK 399
L + A T Q ++ K
Sbjct: 1154 LEE-AGGATSAQIEMNK 1169
Score = 45.4 bits (106), Expect = 9e-05
Identities = 47/232 (20%), Positives = 104/232 (44%), Gaps = 41/232 (17%)
Query: 197 EKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEV--------------- 241
EK + EE K + K + + +L E + LM+ + L++
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELE-EKMVTLMQEKNDLQLQVQAEADSLADAEER 908
Query: 242 ------TKVDVETELQTYKHSRQGLDEMYNEA---RRQLRDE-SQLRQDVENELAVQVSM 291
TK+ +E +++ + +E+ E +R+L DE S+L++D++
Sbjct: 909 CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID--------- 959
Query: 292 KHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARL 351
++EL + +EK+ H ++ + L +++ + ++ ++ + ++ ++ + +
Sbjct: 960 --DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1017
Query: 352 EEKTNKITAAMRQLEQSDNDL---LTQTRTIAMSLVKCASSDTQDQYKLVKD 400
E+K N +T A +LEQ +DL L Q + I M L + A + KL ++
Sbjct: 1018 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLER-AKRKLEGDLKLAQE 1068
Score = 41.2 bits (95), Expect = 0.002
Identities = 41/209 (19%), Positives = 95/209 (45%), Gaps = 20/209 (9%)
Query: 170 DQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENK 229
+Q VE L + + L + ++ E+S +EL A + L +N
Sbjct: 1673 EQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS------ 1726
Query: 230 LILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQV 289
L+ T++ LE ++ E++ + +E +A++ + D + + ++++ E
Sbjct: 1727 --LINTKKKLETDISQIQGEMEDIIQEARNAEE---KAKKAITDAAMMAEELKKEQDTSA 1781
Query: 290 ---SMKHEIELAMKLLEKDIHE-KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKN 345
MK +E +K L+ + E +Q L G ++Q+++++A ++L+G + +++N
Sbjct: 1782 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEA----RVRELEGEVESEQKRN 1837
Query: 346 -EIIARLEEKTNKITAAMRQLEQSDNDLL 373
E + L + K+ Q E+ ++L
Sbjct: 1838 VEAVKGLRKHERKVKELTYQTEEDRKNIL 1866
Score = 37.0 bits (84), Expect = 0.032
Identities = 36/195 (18%), Positives = 83/195 (42%), Gaps = 3/195 (1%)
Query: 177 ELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNII-KLQEENHQLRSENKLI--LM 233
EL R ++ S + E + EEL AK + +LQ+ + + N L
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLE 1419
Query: 234 KTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKH 293
KT+Q L+ D+ +++ + LD+ + L + Q ++ EL
Sbjct: 1420 KTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESR 1479
Query: 294 EIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEE 353
+ + ++ E D L L+++ + ++ ++ +++ + E +I ++E+
Sbjct: 1480 SLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1539
Query: 354 KTNKITAAMRQLEQS 368
+ +++ AA+ + E S
Sbjct: 1540 EKSELQAALEEAEAS 1554
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 56.2 bits (134), Expect = 5e-08
Identities = 58/229 (25%), Positives = 103/229 (44%), Gaps = 36/229 (15%)
Query: 169 LDQKNYVEELNRQLNSTVSSLHSRVDS-------LEKSNTKLIEELAIAKNNIIKLQEEN 221
L+ K E N+QL + + L S D LEKS L +++ + + +L++E
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 222 HQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARR----QLRDESQL 277
Q + KL L + +++ K E +LQT DE E +R Q+R+
Sbjct: 1556 -QATEDAKLRL---EVNMQAMKAQFERDLQTR-------DEQNEEKKRLLIKQVRELEAE 1604
Query: 278 RQDVENELAVQVSMKHEIELAMKLLE--------------KDIHEKQDTLIGLRQQLEEV 323
+D + A+ V+ K ++E+ +K LE K + + Q + +++LEE
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 324 KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDL 372
+A E++ + + SE LK I +L+E+ A R EQ ++L
Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Score = 51.6 bits (122), Expect = 1e-06
Identities = 60/250 (24%), Positives = 111/250 (44%), Gaps = 40/250 (16%)
Query: 151 KNEEDI--GNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELA 208
KN++ + NKE ++ + K E ++L++ V LH++V ++ +L E+ +
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 209 IAKN---NIIKLQEENH----QLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLD 261
+N N+ L EE + + + + Q E+ + + +L RQ L+
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ-LE 1342
Query: 262 EMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLE 321
E N + Q +E + R+++E ++ LA++ D +K D +G + LE
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQV-----------LALQSQLADTKKKVDDDLGTIESLE 1391
Query: 322 EVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKT---NKITAAMRQLEQSDNDL---LTQ 375
E K +KL LK+ + RLEEK +K+ +L+Q +DL L
Sbjct: 1392 EAK-------KKL------LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 376 TRTIAMSLVK 385
R +A +L K
Sbjct: 1439 QRQVASNLEK 1448
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/228 (20%), Positives = 100/228 (43%), Gaps = 22/228 (9%)
Query: 170 DQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENK 229
++ ++ +++ + + L ++D E + KL E A+ I K++EE L +N
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995
Query: 230 LILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQV 289
+ K ++ +E + ++L + + L ++ N+ + + D+E L +
Sbjct: 996 KFI-KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNK-------QEVMISDLEERLKKEE 1047
Query: 290 SMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGS----EDGLKEKN 345
+ E+E A + L+ + + QD + L+ Q++E+K + ++LQG+ +D KN
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 346 EI----------IARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSL 383
IA L+E A+ + E+ DL + + L
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155
Score = 49.3 bits (116), Expect = 6e-06
Identities = 76/360 (21%), Positives = 147/360 (40%), Gaps = 29/360 (8%)
Query: 43 LQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPG-LNEF 101
L ++E K G+K K S + EL+++ + + + +R L N
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348
Query: 102 YEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKER 161
E EEE L + + + L + +D +G I+ EE K++
Sbjct: 1349 QE----QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE-----SLEEA---KKK 1396
Query: 162 NVQIAAILDQKNYVEELNR-QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEE 220
++ A L Q+ + L +L T + L +D L T ++ +N+ K Q++
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL----TVDLDHQRQVASNLEKKQKK 1452
Query: 221 NHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQD 280
QL +E K I + + + + + + + L+E R QLR D
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 281 VENELAVQVSM---KHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGS 337
+E+ ++ + + HE+E + + LE+ + E + L L +L+ + + + +Q
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572
Query: 338 ----EDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQD 393
E L+ ++E + EEK + +R+LE D Q R +A++ K D +D
Sbjct: 1573 KAQFERDLQTRDE---QNEEKKRLLIKQVRELEAELEDERKQ-RALAVASKKKMEIDLKD 1628
Score = 42.4 bits (98), Expect = 8e-04
Identities = 43/163 (26%), Positives = 75/163 (46%), Gaps = 21/163 (12%)
Query: 218 QEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 277
QEE Q + E +L+ +K +Q TKV+ E E KH Q L E N QL+ E++L
Sbjct: 850 QEEELQAKDE-ELLKVKEKQ----TKVEGELEEMERKH--QQLLEEKNILAEQLQAETEL 902
Query: 278 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDT--------------LIGLRQQLEEV 323
+ E A + K E+E + LE + E+++ + L +QL+E
Sbjct: 903 FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 324 KAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLE 366
+ ++ + +E +K+ E I LE++ +K + +E
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Score = 39.3 bits (90), Expect = 0.006
Identities = 47/219 (21%), Positives = 94/219 (42%), Gaps = 21/219 (9%)
Query: 166 AAILDQKNYVE----ELNRQLNSTVSSLHSRVDSLEKSNTK---LIEELAIAKNNIIKLQ 218
+A+LD+K +E +L +L S++ D K+ + L ELA ++ K
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSD 1784
Query: 219 EENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLR 278
QL +NK + K Q+ K +K + L+ + QL E++ R
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVK-------SKFKATISALEAKIGQLEEQLEQEAKER 1837
Query: 279 QDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSE 338
N+L + K + E+ M++ ++ H Q ++Q+E+ A ++ ++L+ +E
Sbjct: 1838 A-AANKLVRRTEKKLK-EIFMQVEDERRHADQ-----YKEQMEKANARMKQLKRQLEEAE 1890
Query: 339 DGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTR 377
+ N +L+ + + T A L + + L + R
Sbjct: 1891 EEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 34.7 bits (78), Expect = 0.16
Identities = 63/347 (18%), Positives = 130/347 (37%), Gaps = 59/347 (17%)
Query: 50 MEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLNEFYEYHALMM 109
+ L+ L+ ++ F NK + +E L +++G +V +L E M
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADME---DLMSSKDDVGKNVHELEKSKRALEQQVEEM 1544
Query: 110 EEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAIL 169
+ L ++ L ED ++ V +M + E D+ +
Sbjct: 1545 RTQ----------LEELEDELQAT-EDAKLRLEVNMQAMKAQFERDLQTR---------- 1583
Query: 170 DQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENK 229
D++N EE R L V L + ++ K + A K I L++ Q+ + NK
Sbjct: 1584 DEQN--EEKKRLLIKQVRELEAELEDERKQRALAV---ASKKKMEIDLKDLEAQIEAANK 1638
Query: 230 LI--LMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQL---------------- 271
++K + L+ D + EL+ + SR + E+ ++L
Sbjct: 1639 ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 272 -----RDESQLRQDVENELAVQVS-------MKHEIELAMKLLEKDIHEKQDTLIGLRQQ 319
R Q R ++ +E+ S K +E + LE+++ E+Q + L +
Sbjct: 1699 SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758
Query: 320 LEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLE 366
+ + +L ++ + +LE + ++ A +++LE
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELE 1805
Score = 28.9 bits (63), Expect = 8.6
Identities = 12/46 (26%), Positives = 26/46 (56%)
Query: 338 EDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSL 383
E+ L+ K+E + +++EK K+ + ++E+ LL + +A L
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL 896
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 56.2 bits (134), Expect = 5e-08
Identities = 64/235 (27%), Positives = 108/235 (45%), Gaps = 25/235 (10%)
Query: 180 RQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHL 239
R L SSL +D LE + TK+ +E +N + L EE L EN L K ++ L
Sbjct: 945 RNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTAL-EENISKLTKEKKSL 1003
Query: 240 EVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAM 299
+ +LQ + GL ++ + +Q D+E L + ++ ++E A
Sbjct: 1004 QEAHQQTLDDLQVEEDKVNGLIKINAKLEQQ-------TDDLEGSLEQEKKLRADLERAK 1056
Query: 300 KLLEKDIHEKQDTLIGL---RQQLEE-VKAINIEMYQKLQGSEDG--------LKEKNEI 347
+ LE D+ Q++++ L +QQ+EE +K E+ Q LQ D K+ E+
Sbjct: 1057 RKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ-LQAKIDDEQVHSLQFQKKIKEL 1115
Query: 348 IARLEEKTNKITA---AMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQYKLVK 399
AR+EE +I A ++E+ +DL + I+ L + AS T Q ++ K
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEE-ASGATSAQIEMNK 1169
Score = 42.7 bits (99), Expect = 6e-04
Identities = 63/340 (18%), Positives = 140/340 (41%), Gaps = 57/340 (16%)
Query: 77 LVEKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGED 136
L E++ E I ++ L E ++ ++ E + GL+ I+A L + +D
Sbjct: 982 LSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIK----INAKLEQQTDD 1037
Query: 137 LDSQVGVIDFSMYLKNEEDIGNKERNVQ---------IAAILDQKNYVEELNRQLNSTVS 187
L+ + K D+ +R ++ I + + K +EE ++ +S
Sbjct: 1038 LEGSL-----EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELS 1092
Query: 188 SLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVE 247
L +++D E+ H L+ + K+ + L+ ++E
Sbjct: 1093 QLQAKID-----------------------DEQVHSLQFQKKI------KELQARIEELE 1123
Query: 248 TELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIH 307
E++ R +++ ++ R+L + S+ ++ + Q+ M + E + + +D+
Sbjct: 1124 EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 308 E----KQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGL-KEKNEIIARLEEKTNKITAAM 362
E + T LR++ + A E LQ + L KEK+E+ +++ + I A
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEA-- 1241
Query: 363 RQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQYKLVKDIS 402
L +S +++ RT+ + + D Q Q +L+ D++
Sbjct: 1242 --LSKSKSNIERTCRTVEDQFSEIKAKDEQ-QTQLIHDLN 1278
Score = 41.2 bits (95), Expect = 0.002
Identities = 41/189 (21%), Positives = 94/189 (49%), Gaps = 15/189 (7%)
Query: 191 SRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETEL 250
+R LE+ L++E N ++LQ ++ +EN + + + L +K+ +E ++
Sbjct: 872 ARRKELEEKMVSLLQE-----KNDLQLQVQSE---TENLMDAEERCEGLIKSKILLEAKV 923
Query: 251 QTYKHSRQGLDEMYNEA---RRQLRDE-SQLRQDVEN---ELAVQVSMKHEIELAMKLLE 303
+ + +EM +E +R L D+ S L++D+++ L KH E +K L
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983
Query: 304 KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMR 363
+++ ++ + L ++ + ++ + + LQ ED + +I A+LE++T+ + ++
Sbjct: 984 EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 364 QLEQSDNDL 372
Q ++ DL
Sbjct: 1044 QEKKLRADL 1052
Score = 40.0 bits (92), Expect = 0.004
Identities = 50/228 (21%), Positives = 98/228 (42%), Gaps = 14/228 (6%)
Query: 176 EELNRQLNSTVSSLHSRVDSLEKSNTKLIEELA---IAKNNIIKLQEENHQLRSENKLIL 232
EE NS +SL L+ L+ +L A + K Q ++ +E K L
Sbjct: 1405 EENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464
Query: 233 MKTQQHLEVTKVD---VETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQV 289
++Q LE + + + TEL +++ + + + RR+ ++ + D+ ++A
Sbjct: 1465 DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524
Query: 290 SMKHEIELAMKLLEKDIHEKQDTLIGLRQQLE----EVKAINIEMYQKLQGSEDGLKEKN 345
E E KL+E++ + Q L + LE ++ + +E+ Q + + EK+
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKD 1584
Query: 346 EIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQD 393
E I +L+ + + A+ QS D ++R A+ L K D +
Sbjct: 1585 EEIEQLKRNSQRAAEAL----QSVLDAEIRSRNDALRLKKKMEGDLNE 1628
Score = 38.9 bits (89), Expect = 0.008
Identities = 45/229 (19%), Positives = 105/229 (45%), Gaps = 14/229 (6%)
Query: 137 LDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSL 196
LD+++ + ++ LK + + E +Q+ Q ++ R + + +D
Sbjct: 1605 LDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDA 1664
Query: 197 EKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTK---VDVETELQTY 253
+SN L E+LAI + L EE E K+ L +T++ +++ +D +Q
Sbjct: 1665 LRSNEDLKEQLAIVERRNGLLLEE----LEEMKVALEQTERTRRLSEQELLDASDRVQLL 1720
Query: 254 KHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAM---KLLEKDIHEKQ 310
HS+ + N ++ D +Q + +VEN + + + + + A+ ++ +++ ++Q
Sbjct: 1721 -HSQN--TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ 1777
Query: 311 DTLIGLRQQLEEVKAINIEMYQKLQGSED-GLKEKNEIIARLEEKTNKI 358
DT L + + ++ ++ +L +E LK + I +LE + ++
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVREL 1826
Score = 37.7 bits (86), Expect = 0.019
Identities = 40/195 (20%), Positives = 82/195 (42%), Gaps = 3/195 (1%)
Query: 177 ELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNII-KLQE--ENHQLRSENKLILM 233
EL R L+ S + E + EEL AK + +LQE EN + + L
Sbjct: 1360 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE 1419
Query: 234 KTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKH 293
KT+Q L+ D+ +L+ + LD+ + L + Q + + EL
Sbjct: 1420 KTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR 1479
Query: 294 EIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEE 353
+ + + E D L LR++ + ++ ++ +++ + L+E + +E+
Sbjct: 1480 SLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQ 1539
Query: 354 KTNKITAAMRQLEQS 368
+ + + A+ ++E S
Sbjct: 1540 EKSDLQVALEEVEGS 1554
Score = 36.2 bits (82), Expect = 0.054
Identities = 35/169 (20%), Positives = 73/169 (43%), Gaps = 22/169 (13%)
Query: 205 EELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMY 264
EELA ++ +L+E+ L E + ++ Q E +D E + S+ L+
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQSETE-NLMDAEERCEGLIKSKILLEAKV 923
Query: 265 NEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVK 324
E +L +E ++ ++ V+ K +E L++DI + + TL + ++
Sbjct: 924 KELTERLEEEEEMNSEL-------VAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH--- 973
Query: 325 AINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLL 373
+E+ +K +E + LEE +K+T + L+++ L
Sbjct: 974 -----------ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTL 1011
Score = 35.8 bits (81), Expect = 0.071
Identities = 36/195 (18%), Positives = 83/195 (42%), Gaps = 20/195 (10%)
Query: 176 EELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKT 235
+++ R L + +L K + EL +N+ +++++ + +SE K+ +
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235
Query: 236 QQHLEV---TKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMK 292
++E +K ++E +T +++ ++E + + ++QL D+ + A +
Sbjct: 1236 ASNIEALSKSKSNIERTCRT-------VEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQN 1288
Query: 293 HEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLE 352
E+ ++ E I + + L QQLEE+K + E+ K KN + L+
Sbjct: 1289 GELSHRVEEKESLISQLTKSKQALTQQLEELK----------RQMEEETKAKNAMAHALQ 1338
Query: 353 EKTNKITAAMRQLEQ 367
+ Q E+
Sbjct: 1339 SSRHDCDLLREQYEE 1353
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 55.1 bits (131), Expect = 1e-07
Identities = 50/217 (23%), Positives = 100/217 (46%), Gaps = 19/217 (8%)
Query: 169 LDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSEN 228
++QK +E LN+Q + + L S D + KS +L + + + +++ + +L E
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE- 1547
Query: 229 KLILMKTQQHLEVTKVDVETELQTYK----HSRQGLDEMYNEARRQL-RDESQLRQDVEN 283
Q E K+ +E LQ K QG DE E ++QL R ++ ++E+
Sbjct: 1548 -------LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 284 EL---AVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDG 340
E ++ V+ + ++E+ +K LE I +QL +++A +M ++ +D
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA---QMKDCMRELDDT 1657
Query: 341 LKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTR 377
+ EI+A+ +E K+ + ++ Q +L R
Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAER 1694
Score = 51.2 bits (121), Expect = 2e-06
Identities = 58/276 (21%), Positives = 117/276 (42%), Gaps = 23/276 (8%)
Query: 127 DANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTV 186
+ LC + E+L +++ + EE + E V+ ++ +++ +++ +
Sbjct: 892 ETELCAEAEELRARLTAKKQEL----EEICHDLEARVEEEE--ERCQHLQAEKKKMQQNI 945
Query: 187 SSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDV 246
L +++ E + KL E + + KL+EE L +N L K ++ LE +
Sbjct: 946 QELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQN-CKLAKEKKLLEDRIAEF 1004
Query: 247 ETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDI 306
T L + + L ++ N+ + D +E L + + E+E + LE D
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAMITD-------LEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 307 HEKQDTLIGLRQQLEEVKAINIEMYQKLQGS----EDGLKEKNEIIARLEEKTNKITAAM 362
+ D + L+ Q+ E+K + ++LQ + E+ +KN + ++ E ++I+
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 363 RQLEQ---SDNDLLTQTRTIAMSL--VKCASSDTQD 393
LE S N Q R + L +K DT D
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLD 1153
Score = 51.2 bits (121), Expect = 2e-06
Identities = 55/226 (24%), Positives = 93/226 (41%), Gaps = 29/226 (12%)
Query: 176 EELNRQLNSTVSSLHSR-------VDSLEKSNTKLIEEL----------AIAKNNIIKLQ 218
EE+ R+L + L R D LEK+ T+L +EL + N+ K Q
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Query: 219 EENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLR 278
++ QL +E K I K + + E E + + L EA Q + +L
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERD----RAEAEAREKETKALSLARALEEAMEQKAELERLN 1499
Query: 279 QDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSE 338
+ E+ +S K ++ K +HE + + L QQ+EE+K E+ +LQ +E
Sbjct: 1500 KQFRTEMEDLMSSKDDVG-------KSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552
Query: 339 DG-LKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSL 383
D L+ + + A + + Q E+ L+ Q R + L
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/176 (21%), Positives = 85/176 (48%), Gaps = 10/176 (5%)
Query: 205 EELAIAKNNIIKLQEENHQLRSENKLILMKT-QQHLEVTKVDVETELQTYKHSRQGLDEM 263
EE+ + ++K++E+ QL +EN+L M+T Q L K+ ++ +LQ +E+
Sbjct: 845 EEMMAKEEELVKVREK--QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902
Query: 264 YNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTL---IGLRQQL 320
+ ++ ++ D+E + + ++ K ++++I E ++ L RQ+L
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 321 EEVKAINIEMYQKLQGSEDGLKEKNEIIAR----LEEKTNKITAAMRQLEQSDNDL 372
+ K +KL+ + L+++N +A+ LE++ + T + + E+ L
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL 1018
Score = 42.7 bits (99), Expect = 6e-04
Identities = 65/312 (20%), Positives = 124/312 (39%), Gaps = 28/312 (8%)
Query: 109 MEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKER--NVQIA 166
+EEE A L + +++ + EDL+S+ + + K + D+G + ++
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAE--KQKRDLGEELEALKTELE 1149
Query: 167 AILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRS 226
LD +EL + V+ L ++ K++ I+E+ + ++ E +
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 227 ENKLILMKTQQHLEVTKVDVETELQTY-------KHSR-------QGLDEMYNEARRQLR 272
K L K +Q LE + ++ E++ +H R Q L +NE R
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT 1269
Query: 273 DESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQ 332
+ + ++ EL + + + L KD + L ++ L+E + +
Sbjct: 1270 ELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST 1329
Query: 333 KLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSL---VKCASS 389
KL+ ED EKN +LEE+ A LE+ L Q + + V C +
Sbjct: 1330 KLKQVED---EKNSFREQLEEEEE----AKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 390 DTQDQYKLVKDI 401
+ + KL KD+
Sbjct: 1383 AEEVKRKLQKDL 1394
Score = 40.8 bits (94), Expect = 0.002
Identities = 55/238 (23%), Positives = 107/238 (44%), Gaps = 40/238 (16%)
Query: 155 DIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHS----------RVDSLEKSNTKLI 204
D NK R+ I + + +++ R+L+ T +S ++ S+E +L
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686
Query: 205 EELAIAKNNIIKLQEENHQLRSE------NKLILMKTQQHLEVTKVDVETELQTYKHSRQ 258
EELA A+ + Q+E +L E + ++ ++ LE +E EL+ Q
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE----EEQ 1742
Query: 259 GLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQ 318
G E+ N+ +L+ + + +L ++ S + E A + LE+ E L+
Sbjct: 1743 GNTELIND---RLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE-------LKV 1792
Query: 319 QLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEE----KTNKITAAMRQLEQSDNDL 372
+L+E++ + K + S L+ K IA+LEE +T + AA +Q+ +++ L
Sbjct: 1793 KLQEMEG---TVKSKYKASITALEAK---IAQLEEQLDNETKERQAACKQVRRTEKKL 1844
Score = 40.4 bits (93), Expect = 0.003
Identities = 49/216 (22%), Positives = 94/216 (43%), Gaps = 27/216 (12%)
Query: 164 QIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKL---IEELAIAKNNIIKLQEE 220
++ +L K E +++ + + L + + E+ T+L + +L + +N+ L +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 221 NHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQD 280
+ S+ L K LE D + LQ + +RQ L + +Q+ DE +
Sbjct: 1292 SDSKSSK----LTKDFSALESQLQDTQELLQ--EENRQKLS--LSTKLKQVEDE---KNS 1340
Query: 281 VENELAVQVSMKHEIELAMKLLE---KDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGS 337
+L + KH +E + L D+ +K + +G + EEVK +KLQ
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK-------RKLQKD 1393
Query: 338 EDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLL 373
+GL +++E +K K +L+Q +DLL
Sbjct: 1394 LEGLSQRHEEKVAAYDKLEK---TKTRLQQELDDLL 1426
Score = 32.3 bits (72), Expect = 0.78
Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 5/87 (5%)
Query: 287 VQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIE-MYQKLQGSEDGLKEKN 345
+QVS + E +A + + EKQ + +L E++ + + M +KLQ E L+ +
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQ---LAAENRLTEMETLQSQLMAEKLQLQEQ-LQAET 893
Query: 346 EIIARLEEKTNKITAAMRQLEQSDNDL 372
E+ A EE ++TA ++LE+ +DL
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDL 920
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 55.1 bits (131), Expect = 1e-07
Identities = 66/287 (22%), Positives = 128/287 (44%), Gaps = 44/287 (15%)
Query: 130 LCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNST---V 186
LC K + L+++V + +E + N +R +Q+ + + + V L + S
Sbjct: 220 LCQKLKGLEAEVAELKAEKE-NSEAQVENAQR-IQVRQLAEMQATVRSLEAEKQSANLRA 277
Query: 187 SSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILM------------- 233
L + S + NT LI +L A+ I L + +L+ NKL +
Sbjct: 278 ERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSEL 337
Query: 234 -----KTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQ--------------LRDE 274
K Q L+ + D E +H + L E E R+ L+DE
Sbjct: 338 ERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDE 397
Query: 275 SQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQL--EEVKAINIEMYQ 332
+ ++EN LA MK E ++ + EKD +E++ + +++ +E++++ +++ Q
Sbjct: 398 ---KLELENRLADLEKMKVEHDV-WRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQ 453
Query: 333 KLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTI 379
++ E+ KEKNE + L+++ + + + L QS+NDLL + +
Sbjct: 454 QIVTIENAEKEKNE-NSDLKQQISSLQIQVTSLAQSENDLLNSNQML 499
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/163 (24%), Positives = 73/163 (44%), Gaps = 20/163 (12%)
Query: 179 NRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQH 238
N L +SSL +V SL +S L+ + K + +L++E RS+ + ++ ++
Sbjct: 468 NSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKT 527
Query: 239 LEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELA 298
LE ++ E +E YN+A+ +L+ + + Q L HE +L
Sbjct: 528 LEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQ-RAAIAQKKRKSL-------HENKL- 578
Query: 299 MKLLEKDIHEKQDTLIGLRQQLE-EVKAIN-----IEMYQKLQ 335
K + EK + L +++LE E + +N E Y +LQ
Sbjct: 579 -----KRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQ 616
Score = 33.1 bits (74), Expect = 0.46
Identities = 35/173 (20%), Positives = 76/173 (43%), Gaps = 13/173 (7%)
Query: 216 KLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDES 275
+L+ E+H+ N L L+ V ++ EL+ + +Q E +LR E
Sbjct: 39 RLRCEHHKA---NYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGEL 95
Query: 276 QLRQDVENELAVQVSMKHEIELAMKLLEKDIH-EKQDTLIGLRQQLEEVKAINIEMYQKL 334
+ E+ +Q+ ++EL +++++ ++ L +++E+ +A+ Y KL
Sbjct: 96 VEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAV----YNKL 151
Query: 335 QGSEDGLK-----EKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMS 382
+ LK +K E L+E K + + +LE+ +L Q + ++
Sbjct: 152 RYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLT 204
>gi|109134355 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 55.1 bits (131), Expect = 1e-07
Identities = 66/287 (22%), Positives = 128/287 (44%), Gaps = 44/287 (15%)
Query: 130 LCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNST---V 186
LC K + L+++V + +E + N +R +Q+ + + + V L + S
Sbjct: 220 LCQKLKGLEAEVAELKAEKE-NSEAQVENAQR-IQVRQLAEMQATVRSLEAEKQSANLRA 277
Query: 187 SSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILM------------- 233
L + S + NT LI +L A+ I L + +L+ NKL +
Sbjct: 278 ERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSEL 337
Query: 234 -----KTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQ--------------LRDE 274
K Q L+ + D E +H + L E E R+ L+DE
Sbjct: 338 ERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEKDRELIRKVQAAKEEGYQKLVVLQDE 397
Query: 275 SQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQL--EEVKAINIEMYQ 332
+ ++EN LA MK E ++ + EKD +E++ + +++ +E++++ +++ Q
Sbjct: 398 ---KLELENRLADLEKMKVEHDV-WRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQ 453
Query: 333 KLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTI 379
++ E+ KEKNE + L+++ + + + L QS+NDLL + +
Sbjct: 454 QIVTIENAEKEKNE-NSDLKQQISSLQIQVTSLAQSENDLLNSNQML 499
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/163 (24%), Positives = 73/163 (44%), Gaps = 20/163 (12%)
Query: 179 NRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQH 238
N L +SSL +V SL +S L+ + K + +L++E RS+ + ++ ++
Sbjct: 468 NSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNFRSQAEKAQLEAEKT 527
Query: 239 LEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELA 298
LE ++ E +E YN+A+ +L+ + + Q L HE +L
Sbjct: 528 LEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQ-RAAIAQKKRKSL-------HENKL- 578
Query: 299 MKLLEKDIHEKQDTLIGLRQQLE-EVKAIN-----IEMYQKLQ 335
K + EK + L +++LE E + +N E Y +LQ
Sbjct: 579 -----KRLQEKVEVLEAKKEELETENQVLNRQNVPFEDYTRLQ 616
Score = 33.1 bits (74), Expect = 0.46
Identities = 35/173 (20%), Positives = 76/173 (43%), Gaps = 13/173 (7%)
Query: 216 KLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDES 275
+L+ E+H+ N L L+ V ++ EL+ + +Q E +LR E
Sbjct: 39 RLRCEHHKA---NYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGEL 95
Query: 276 QLRQDVENELAVQVSMKHEIELAMKLLEKDIH-EKQDTLIGLRQQLEEVKAINIEMYQKL 334
+ E+ +Q+ ++EL +++++ ++ L +++E+ +A+ Y KL
Sbjct: 96 VEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAV----YNKL 151
Query: 335 QGSEDGLK-----EKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMS 382
+ LK +K E L+E K + + +LE+ +L Q + ++
Sbjct: 152 RYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLT 204
>gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
Length = 1505
Score = 54.7 bits (130), Expect = 1e-07
Identities = 87/366 (23%), Positives = 145/366 (39%), Gaps = 51/366 (13%)
Query: 5 DPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDY-----PPLQQFFVVMEHCLKHGLK 59
D TA AN + ++ S K LIE + F + D P L+ F ++ K +
Sbjct: 14 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
Query: 60 VRKSFLS-YNKTIWGP-----LELVEKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEG 113
+FL+ Y + I P L+L ++L + + + + L E E + +E
Sbjct: 74 AEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY----NKEF 129
Query: 114 AVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKN 173
A + V + + + + L +Q I K + D KER +Q
Sbjct: 130 AEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ--------- 180
Query: 174 YVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLI-- 231
E S + +V SL+ + K EL K K EE E ++I
Sbjct: 181 ---ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKT---KYDEETTAKADEIEMIMT 234
Query: 232 -LMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQ--DVENELAVQ 288
L + Q EV + + ET L E + A L+ SQ+++ DVE + V
Sbjct: 235 DLERANQRAEVAQREAET-----------LREQLSSANHSLQLASQIQKAPDVEQAIEVL 283
Query: 289 VSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEII 348
E+ELA K E++I + + + L+ L +++ + +L E L KN +
Sbjct: 284 TRSSLEVELAAK--EREIAQLVEDVQRLQASLTKLRENSASQISQL---EQQLSAKNSTL 338
Query: 349 ARLEEK 354
+LEEK
Sbjct: 339 KQLEEK 344
Score = 42.0 bits (97), Expect = 0.001
Identities = 54/249 (21%), Positives = 100/249 (40%), Gaps = 45/249 (18%)
Query: 130 LCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILD-QKNYVEELNRQLNSTVSS 188
LCV G L ++ + L N +D + R I + +KN E+L +Q+ + S
Sbjct: 2 LCVAGARLKRELDAT--ATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS 59
Query: 189 LHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVET 248
+D+L K + + +I + + L +L L + H D+ET
Sbjct: 60 FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH------DIET 113
Query: 249 ELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHE 308
E Q + + + ++ + E + Q E+ +K L++ I E
Sbjct: 114 ENQKLRETLEEYNKEFAEVKNQ-------------------------EVTIKALKEKIRE 148
Query: 309 KQDTLIGLRQQLEEVKAINIEMYQKLQG----SEDGLKE-KNEIIARLEEKTNKITAAMR 363
+ TL + + I +E QKLQ E L+E + ++LEE +K+ +
Sbjct: 149 YEQTL------KNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQT 202
Query: 364 QLEQSDNDL 372
LE++ +L
Sbjct: 203 ALEKTRTEL 211
Score = 40.0 bits (92), Expect = 0.004
Identities = 43/201 (21%), Positives = 86/201 (42%), Gaps = 21/201 (10%)
Query: 178 LNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQ 237
L R+L++T + L +R D E+S +LIE+ K N LR + +L Q
Sbjct: 9 LKRELDATATVLANRQDESEQSRKRLIEQSREFKKN------TPEDLRKQVAPLLKSFQG 62
Query: 238 HLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL-RQDVENELAVQVSMKHEIE 296
++ K S++ N +R + + D+ +L ++V H+IE
Sbjct: 63 EIDALS----------KRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIE 112
Query: 297 LAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTN 356
+ L + + E ++ Q +KA+ +K++ E LK + E IA +E+
Sbjct: 113 TENQKLRETLEEYNKEFAEVKNQEVTIKALK----EKIREYEQTLKNQAETIALEKEQKL 168
Query: 357 KITAAMRQLEQSDNDLLTQTR 377
+ A ++ + + + T ++
Sbjct: 169 QNDFAEKERKLQETQMSTTSK 189
>gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]
Length = 678
Score = 54.7 bits (130), Expect = 1e-07
Identities = 87/366 (23%), Positives = 145/366 (39%), Gaps = 51/366 (13%)
Query: 5 DPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDY-----PPLQQFFVVMEHCLKHGLK 59
D TA AN + ++ S K LIE + F + D P L+ F ++ K +
Sbjct: 25 DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 84
Query: 60 VRKSFLS-YNKTIWGP-----LELVEKLYPEAEEIGASVRDLPGLNEFYEYHALMMEEEG 113
+FL+ Y + I P L+L ++L + + + + L E E + +E
Sbjct: 85 AEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY----NKEF 140
Query: 114 AVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKN 173
A + V + + + + L +Q I K + D KER +Q
Sbjct: 141 AEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ--------- 191
Query: 174 YVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLI-- 231
E S + +V SL+ + K EL K K EE E ++I
Sbjct: 192 ---ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKT---KYDEETTAKADEIEMIMT 245
Query: 232 -LMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQ--DVENELAVQ 288
L + Q EV + + ET L E + A L+ SQ+++ DVE + V
Sbjct: 246 DLERANQRAEVAQREAET-----------LREQLSSANHSLQLASQIQKAPDVEQAIEVL 294
Query: 289 VSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEII 348
E+ELA K E++I + + + L+ L +++ + +L E L KN +
Sbjct: 295 TRSSLEVELAAK--EREIAQLVEDVQRLQASLTKLRENSASQISQL---EQQLSAKNSTL 349
Query: 349 ARLEEK 354
+LEEK
Sbjct: 350 KQLEEK 355
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/204 (21%), Positives = 89/204 (43%), Gaps = 21/204 (10%)
Query: 175 VEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMK 234
+++L R+L++T + L +R D E+S +LIE+ K N LR + +L
Sbjct: 17 LQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKN------TPEDLRKQVAPLLKS 70
Query: 235 TQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL-RQDVENELAVQVSMKH 293
Q ++ K S++ N +R + + D+ +L ++V H
Sbjct: 71 FQGEIDALS----------KRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 120
Query: 294 EIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEE 353
+IE + L + + E ++ Q +KA+ +K++ E LK + E IA +E
Sbjct: 121 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALK----EKIREYEQTLKNQAETIALEKE 176
Query: 354 KTNKITAAMRQLEQSDNDLLTQTR 377
+ + A ++ + + + T ++
Sbjct: 177 QKLQNDFAEKERKLQETQMSTTSK 200
Score = 38.9 bits (89), Expect = 0.008
Identities = 49/229 (21%), Positives = 92/229 (40%), Gaps = 43/229 (18%)
Query: 150 LKNEEDIGNKERNVQIAAILD-QKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELA 208
L N +D + R I + +KN E+L +Q+ + S +D+L K + +
Sbjct: 31 LANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFL 90
Query: 209 IAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEAR 268
+I + + L +L L + H D+ETE Q + + + ++ + E +
Sbjct: 91 NVYKRLIDVPDPVPALDLGQQLQLKVQRLH------DIETENQKLRETLEEYNKEFAEVK 144
Query: 269 RQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINI 328
Q E+ +K L++ I E + TL + + I +
Sbjct: 145 NQ-------------------------EVTIKALKEKIREYEQTL------KNQAETIAL 173
Query: 329 EMYQKLQG----SEDGLKE-KNEIIARLEEKTNKITAAMRQLEQSDNDL 372
E QKLQ E L+E + ++LEE +K+ + LE++ +L
Sbjct: 174 EKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTEL 222
>gi|4504063 golgin 97 [Homo sapiens]
Length = 767
Score = 53.9 bits (128), Expect = 3e-07
Identities = 62/310 (20%), Positives = 131/310 (42%), Gaps = 45/310 (14%)
Query: 109 MEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFS------MYLKNEEDIGNKERN 162
+E+E ++ L + NL + +++D G M LK EE +G E+
Sbjct: 142 LEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIKHMLLKKEESLGKMEQE 201
Query: 163 VQ-----IAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKL 217
++ ++ ++ +++ L+ + L +LE+ +I A++ I L
Sbjct: 202 LEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVIASKTGAESKITAL 261
Query: 218 QEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 277
+++ +L++ + Q +++ KV ET+ + D + + + E +L
Sbjct: 262 EQKEQELQA------LIQQLSIDLQKVTAETQEKE--------DVITHLQEKVASLEKRL 307
Query: 278 RQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINI------EMY 331
Q++ E VQ +K + L E+++ + + L+ R + KAIN E+
Sbjct: 308 EQNLSGEEHVQELLKEKT-----LAEQNLEDTRQQLLAARSS--QAKAINTLETRVRELE 360
Query: 332 QKLQGSEDGLKEKNEIIARLEEKTNKITAA-------MRQLEQSDNDLLTQTRTIAMSLV 384
Q LQ SE+ L++ I+A E + ++ AA +Q + L +T+ + +V
Sbjct: 361 QTLQASEEQLQQSKGIVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEAQIV 420
Query: 385 KCASSDTQDQ 394
+ DQ
Sbjct: 421 ALERTRAADQ 430
Score = 52.0 bits (123), Expect = 1e-06
Identities = 55/230 (23%), Positives = 98/230 (42%), Gaps = 29/230 (12%)
Query: 161 RNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEE 220
R+ Q AI + V EL + L ++ L + T+ I+ELA A +Q++
Sbjct: 342 RSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQ-IQELAAANQESSHVQQQ 400
Query: 221 NHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQD 280
L QQ LE T+ +E ++ + +R + RQL E+ ++
Sbjct: 401 ----------ALALEQQFLERTQA-LEAQIVALERTRAADQTTAEQGMRQLEQENAALKE 449
Query: 281 VENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK------- 333
NE + H+ EL K L+++ +++ + + Q LEEV+ E Q+
Sbjct: 450 CRNEYERSLQ-NHQFEL--KKLKEEWSQREIVSVAMAQALEEVRKQREEFQQQAANLTAI 506
Query: 334 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSL 383
+ E L+EK E++ + E++ + QLE+ N L Q + L
Sbjct: 507 IDEKEQNLREKTEVLLQKEQE-------ILQLERGHNSALLQIHQLQAEL 549
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 53.1 bits (126), Expect = 4e-07
Identities = 50/207 (24%), Positives = 105/207 (50%), Gaps = 19/207 (9%)
Query: 174 YVEELNRQLNSTVSSLHSRV---DSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSE--- 227
Y+EEL ++ ++ L+ + L+K N +L E+L +A++ ++Q +L+ +
Sbjct: 198 YIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLER 257
Query: 228 NKLILMKTQQHL---EVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENE 284
K +L + Q + E+ + + E Q K +Q ++M+ + R E ++R+ E +
Sbjct: 258 AKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQE-EKMWRQEERLREQEGKMREQ-EEK 315
Query: 285 LAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEK 344
+ Q E E ++ EK++ E+++ LR+Q E+++ E +K+ E+ ++E+
Sbjct: 316 MWRQEKRLREQEKELREQEKELREQKE----LREQEEQMQ----EQEEKMWEQEEKMREQ 367
Query: 345 NEIIARLEEKTNKITAAMRQLEQSDND 371
E + R EE+ + MR+ EQ D
Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRD 394
Score = 43.1 bits (100), Expect = 4e-04
Identities = 41/217 (18%), Positives = 98/217 (45%), Gaps = 8/217 (3%)
Query: 151 KNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIA 210
+ EE I +E+ + ++K + +E R+ S+ R + + + E+
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE----EESMREREKKMREEEEMMREQEEKM 736
Query: 211 KNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQ 270
+ K+QE+ ++ + + + + ++ E ++ + E + ++H + E E +
Sbjct: 737 QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE-KLWEHEKMQEQEKIWEQEEK 795
Query: 271 LRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEM 330
+RD+ + + E ++ Q E M E+ + +++ + G Q E++ +M
Sbjct: 796 MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG---QEEKMWGQEEKM 852
Query: 331 YQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
+K+QG E+ ++E+ E + EEK + MR E+
Sbjct: 853 EEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Score = 35.8 bits (81), Expect = 0.071
Identities = 31/184 (16%), Positives = 81/184 (44%), Gaps = 7/184 (3%)
Query: 171 QKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKL 230
++ + E +++ + + + +++ K+ E+ K+QE+ ++ + +
Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Query: 231 ILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVS 290
+ + ++ E ++ + E Q ++M + + E ++ E E
Sbjct: 647 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ 706
Query: 291 MKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIAR 350
K E +M+ EK + E+++ + R+Q E+++ E +K+Q E+ + E+ E +
Sbjct: 707 EKMREEESMREREKKMREEEEMM---REQEEKMQ----EQEEKMQEQEEEMWEQEEKMWE 759
Query: 351 LEEK 354
EEK
Sbjct: 760 QEEK 763
Score = 31.2 bits (69), Expect = 1.7
Identities = 32/154 (20%), Positives = 68/154 (44%), Gaps = 9/154 (5%)
Query: 216 KLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDES 275
KL E+ E K+ + + + E ++ + R+ D+M+ E ++RD+
Sbjct: 499 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW-EQEEKMRDQE 557
Query: 276 QLRQDVEN--ELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 333
Q D E E Q K + K+ E++ +++ +++ E + + E +K
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE------KKMREEEEMMREQEEK 611
Query: 334 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
+Q E+ ++E+ E + EEK + M + E+
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEE 645
>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
sapiens]
Length = 1185
Score = 53.1 bits (126), Expect = 4e-07
Identities = 58/265 (21%), Positives = 125/265 (47%), Gaps = 42/265 (15%)
Query: 157 GNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIK 216
G+ +A +++ + + + +R+ S + R+ SL T+L E+L A+ ++IK
Sbjct: 241 GSLSHEEDLAKVIELQEIISKQSREQ----SQMKERLASLSSHVTELEEDLDTARKDLIK 296
Query: 217 LQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQ 276
+E N +L+ + + + + K D+E + T L++ Y A+R+
Sbjct: 297 SEEMNTKLQRDVREAMAQ--------KEDMEERITT-------LEKRYLAAQREATSVHD 341
Query: 277 LRQDVENELAVQVSM-----------KHEIELAMKLLEKDIHEKQDTLIGLRQQL-EEVK 324
L +ENE+A + SM + +ELA + L++ + K +TL + +L + V
Sbjct: 342 LNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTL-RKAETLPEVEAELAQRVA 400
Query: 325 AI--------NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQT 376
A+ NIE ++L+ E L+EKN+ + R ++ ++L + + LL+++
Sbjct: 401 ALSKAEERHGNIE--ERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSES 458
Query: 377 RTIAMSLVKCASSDTQDQYKLVKDI 401
+K + +D+ L++++
Sbjct: 459 NERLQLHLKERMAALEDKNSLLREV 483
Score = 33.5 bits (75), Expect = 0.35
Identities = 50/223 (22%), Positives = 89/223 (39%), Gaps = 50/223 (22%)
Query: 150 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 209
+K+EE +R+V+ A + QK +EE L + S+ N KL E+A
Sbjct: 295 IKSEEMNTKLQRDVREA--MAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIAN 352
Query: 210 AKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKV--DVETELQ------TYKHSRQG-L 260
+ + +++N QL+ +L K QQ L + +VE EL + R G +
Sbjct: 353 KDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNI 412
Query: 261 DEMYNEARRQLRDESQLRQDV-----------------------ENELAVQVSMKH---- 293
+E + QL +++Q Q E+ +Q+ +K
Sbjct: 413 EERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAA 472
Query: 294 ---------EIELAMKLLEKDIHEKQDTLI---GLRQQLEEVK 324
E+E A K LE+ H+K ++ LR +L+ ++
Sbjct: 473 LEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMR 515
>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo
sapiens]
Length = 1202
Score = 53.1 bits (126), Expect = 4e-07
Identities = 58/265 (21%), Positives = 125/265 (47%), Gaps = 42/265 (15%)
Query: 157 GNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIK 216
G+ +A +++ + + + +R+ S + R+ SL T+L E+L A+ ++IK
Sbjct: 241 GSLSHEEDLAKVIELQEIISKQSREQ----SQMKERLASLSSHVTELEEDLDTARKDLIK 296
Query: 217 LQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQ 276
+E N +L+ + + + + K D+E + T L++ Y A+R+
Sbjct: 297 SEEMNTKLQRDVREAMAQ--------KEDMEERITT-------LEKRYLAAQREATSVHD 341
Query: 277 LRQDVENELAVQVSM-----------KHEIELAMKLLEKDIHEKQDTLIGLRQQL-EEVK 324
L +ENE+A + SM + +ELA + L++ + K +TL + +L + V
Sbjct: 342 LNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTL-RKAETLPEVEAELAQRVA 400
Query: 325 AI--------NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQT 376
A+ NIE ++L+ E L+EKN+ + R ++ ++L + + LL+++
Sbjct: 401 ALSKAEERHGNIE--ERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSES 458
Query: 377 RTIAMSLVKCASSDTQDQYKLVKDI 401
+K + +D+ L++++
Sbjct: 459 NERLQLHLKERMAALEDKNSLLREV 483
Score = 33.5 bits (75), Expect = 0.35
Identities = 50/223 (22%), Positives = 89/223 (39%), Gaps = 50/223 (22%)
Query: 150 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 209
+K+EE +R+V+ A + QK +EE L + S+ N KL E+A
Sbjct: 295 IKSEEMNTKLQRDVREA--MAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIAN 352
Query: 210 AKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKV--DVETELQ------TYKHSRQG-L 260
+ + +++N QL+ +L K QQ L + +VE EL + R G +
Sbjct: 353 KDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNI 412
Query: 261 DEMYNEARRQLRDESQLRQDV-----------------------ENELAVQVSMKH---- 293
+E + QL +++Q Q E+ +Q+ +K
Sbjct: 413 EERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAA 472
Query: 294 ---------EIELAMKLLEKDIHEKQDTLI---GLRQQLEEVK 324
E+E A K LE+ H+K ++ LR +L+ ++
Sbjct: 473 LEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMR 515
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 53.1 bits (126), Expect = 4e-07
Identities = 85/428 (19%), Positives = 179/428 (41%), Gaps = 76/428 (17%)
Query: 34 RTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVR 93
R+L +D L+Q + E LK ++ K + + + EKL E +++ +
Sbjct: 1499 RSLQADAKDLEQHKIKQEEILK---EINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI- 1554
Query: 94 DLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGED---LDSQVG-------- 142
++ NE ++H +++E ++ L + + + + ++ LD Q+G
Sbjct: 1555 EMAERNE--DHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL 1612
Query: 143 ----VIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQ---LNSTVSSLHSRVDS 195
++ L+ +G E + I + K+ +EEL+ Q LN +S +++
Sbjct: 1613 LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTL 1672
Query: 196 LEKSNTKLIEELAIA-----------KNNIIKLQEENHQLRS------------------ 226
+++ K E L + KN + LQ ENH+L+
Sbjct: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
Query: 227 --ENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARR---------QLRDES 275
E KL L QQ + K ++E + Q + ++ ++ M E+R + +++
Sbjct: 1733 VLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDL 1792
Query: 276 QLRQDV-ENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKL 334
Q + D+ E +LA + E K+ + ++ + + + L+Q+L+++ + ++ +
Sbjct: 1793 QEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI 1852
Query: 335 QGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTIAMSLVKCASSDTQDQ 394
+ L+EK E + L+E ++ L + DLL T+ + L +Q
Sbjct: 1853 SAMQQQLQEKREAVNSLQE---ELANVQDHLNLAKQDLLHTTKHQDVLL--------SEQ 1901
Query: 395 YKLVKDIS 402
+L KDIS
Sbjct: 1902 TRLQKDIS 1909
Score = 44.3 bits (103), Expect = 2e-04
Identities = 52/227 (22%), Positives = 98/227 (43%), Gaps = 33/227 (14%)
Query: 151 KNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIA 210
K + + +E + I +L +K +E +L+ TV + D ++ + L+ EL I
Sbjct: 1349 KRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE 1408
Query: 211 KNNIIKLQEEN-HQLRSENKLILMKTQQHLEVTKV--DVETELQTYKHSRQGLDEMYNEA 267
K+ +K E+ ++ K +L + + E ++ + E+EL K + E + +A
Sbjct: 1409 KS--LKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 1466
Query: 268 RRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAIN 327
+R L Q D E LE+ E L+ QQL ++A
Sbjct: 1467 KRSLL---QTESDAEE------------------LERRAQETAVNLVKADQQLRSLQADA 1505
Query: 328 IEMYQKLQGSEDGLKEKNEIIAR-------LEEKTNKITAAMRQLEQ 367
++ Q E+ LKE N+I+A L +K K+T +++L++
Sbjct: 1506 KDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1552
Score = 40.4 bits (93), Expect = 0.003
Identities = 47/216 (21%), Positives = 88/216 (40%), Gaps = 9/216 (4%)
Query: 165 IAAILDQKNYVEELNRQLNS-TVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQ 223
++ I + +++L QL +++ + LE + L E L K + Q E +
Sbjct: 582 LSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRK 641
Query: 224 LRSENKLILMKTQQ------HLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 277
LR E + +L + + LE+ +D E + L E + E L+
Sbjct: 642 LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQH-EVNASLQQTQGD 700
Query: 278 RQDVENELAVQVSMKH-EIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQG 336
E EL +++++ E + LEK Q L+ +LE+ + K Q
Sbjct: 701 LSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQF 760
Query: 337 SEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDL 372
SE+ +E +E+ A+L+ + +QL+ N L
Sbjct: 761 SEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHL 796
Score = 37.0 bits (84), Expect = 0.032
Identities = 52/269 (19%), Positives = 115/269 (42%), Gaps = 30/269 (11%)
Query: 153 EEDIGNKERNVQIAA--ILDQKNYVEEL---NRQLNSTVSSLHSRVDSLEKSNTKLIEEL 207
+E++ N + ++ +A +L + + L +L +S +R + +K ++L
Sbjct: 1870 QEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQL 1929
Query: 208 AIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEA 267
+ +N I ENKL L++ + + + + E+E + S+ L E ++
Sbjct: 1930 QVLQNEI-----------EENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQL 1978
Query: 268 RRQLRDE-SQLRQDVENELAVQ--VSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVK 324
++L D+ S+L Q + LA + V E E + LEK + + + L QQL E
Sbjct: 1979 EKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
Query: 325 AINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMR-----QLEQSDNDLLTQTRTI 379
+ + ++ +K K A+++ Q Q + +LL Q +
Sbjct: 2039 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQEN 2098
Query: 380 A-----MSLVKCASSDTQDQ-YKLVKDIS 402
+ M+ ++ + D ++ +L+K+++
Sbjct: 2099 SCIQKEMATIELVAQDNHERARRLMKELN 2127
Score = 35.0 bits (79), Expect = 0.12
Identities = 49/241 (20%), Positives = 105/241 (43%), Gaps = 31/241 (12%)
Query: 150 LKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAI 209
L+ + +G E N+ + + K+ + +L +Q + ++ D + KL EE+A+
Sbjct: 816 LRRKLKLGTGEMNIHSPSDVLGKS-LADLQKQFSEILARSKWERDEAQVRERKLQEEMAL 874
Query: 210 AKNNIIKLQEENHQL--RSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEA 267
+ + QEE Q R+ + +QH E +E E+ + + + ++E+
Sbjct: 875 QQEKLATGQEEFRQACERALEARMNFDKRQH-EARIQQMENEIHYLQENLKSMEEIQGLT 933
Query: 268 RRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAIN 327
QL++ + ++ + +L E+E KL + + Q+ + GL ++L+++K
Sbjct: 934 DLQLQEADEEKERILAQL-------RELEKKKKLEDA---KSQEQVFGLDKELKKLKKA- 982
Query: 328 IEMYQKLQGSE-----DGLK-----------EKNEIIARLEEKTNKITAAMRQLEQSDND 371
+ KL +E D LK E+ E + E + K A R L +++ +
Sbjct: 983 VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 1042
Query: 372 L 372
+
Sbjct: 1043 I 1043
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,806,698
Number of Sequences: 37866
Number of extensions: 547871
Number of successful extensions: 5004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 684
Number of HSP's that attempted gapping in prelim test: 2705
Number of HSP's gapped (non-prelim): 2282
length of query: 403
length of database: 18,247,518
effective HSP length: 105
effective length of query: 298
effective length of database: 14,271,588
effective search space: 4252933224
effective search space used: 4252933224
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.