Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 109150425

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109150425 ankyrin repeat and zinc finger domain containing 1
[Homo sapiens]
         (726 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109150435 ankyrin repeat and zinc finger domain containing 1 ...  1454   0.0  
gi|109150425 ankyrin repeat and zinc finger domain containing 1 ...  1454   0.0  
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ...    54   7e-07
gi|10863929 ribonuclease L [Homo sapiens]                              49   1e-05
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    48   3e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    48   3e-05
gi|6912326 family with sequence similarity 50, member B [Homo sa...    48   4e-05
gi|154354979 myosin X [Homo sapiens]                                   47   8e-05
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 45   2e-04
gi|239745093 PREDICTED: hypothetical protein XP_002343359 [Homo ...    45   3e-04
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    45   3e-04
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    45   3e-04
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    45   3e-04
gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo sa...    45   3e-04
gi|15529978 zinc finger protein 622 [Homo sapiens]                     45   3e-04
gi|89941470 ankyrin repeat domain 34 [Homo sapiens]                    45   3e-04
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]             44   4e-04
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]             44   4e-04
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    44   5e-04
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...    44   7e-04
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...    44   7e-04
gi|239743649 PREDICTED: IQ motif and ankyrin repeat domain-conta...    44   7e-04
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso...    43   0.001
gi|148746195 trichohyalin [Homo sapiens]                               43   0.001
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso...    43   0.001
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     43   0.001
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    42   0.002
gi|55956910 meningioma  1 [Homo sapiens]                               42   0.002
gi|21361517 UBX domain protein 1 [Homo sapiens]                        42   0.002
gi|17017963 forkhead box P2 isoform I [Homo sapiens]                   42   0.002

>gi|109150435 ankyrin repeat and zinc finger domain containing 1
           [Homo sapiens]
          Length = 726

 Score = 1454 bits (3765), Expect = 0.0
 Identities = 726/726 (100%), Positives = 726/726 (100%)

Query: 1   MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERK 60
           MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERK
Sbjct: 1   MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERK 60

Query: 61  LLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSS 120
           LLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSS
Sbjct: 61  LLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSS 120

Query: 121 TGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRC 180
           TGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRC
Sbjct: 121 TGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRC 180

Query: 181 VLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRA 240
           VLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRA
Sbjct: 181 VLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRA 240

Query: 241 KRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPR 300
           KRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPR
Sbjct: 241 KRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPR 300

Query: 301 SGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLH 360
           SGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLH
Sbjct: 301 SGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLH 360

Query: 361 SPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVEL 420
           SPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVEL
Sbjct: 361 SPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVEL 420

Query: 421 TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLG 480
           TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLG
Sbjct: 421 TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLG 480

Query: 481 PLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLH 540
           PLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLH
Sbjct: 481 PLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLH 540

Query: 541 AAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA 600
           AAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA
Sbjct: 541 AAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA 600

Query: 601 QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL 660
           QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL
Sbjct: 601 QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL 660

Query: 661 AAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQ 720
           AAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQ
Sbjct: 661 AAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQ 720

Query: 721 AGRPSS 726
           AGRPSS
Sbjct: 721 AGRPSS 726


>gi|109150425 ankyrin repeat and zinc finger domain containing 1
           [Homo sapiens]
          Length = 726

 Score = 1454 bits (3765), Expect = 0.0
 Identities = 726/726 (100%), Positives = 726/726 (100%)

Query: 1   MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERK 60
           MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERK
Sbjct: 1   MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERK 60

Query: 61  LLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSS 120
           LLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSS
Sbjct: 61  LLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSS 120

Query: 121 TGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRC 180
           TGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRC
Sbjct: 121 TGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRC 180

Query: 181 VLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRA 240
           VLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRA
Sbjct: 181 VLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRA 240

Query: 241 KRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPR 300
           KRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPR
Sbjct: 241 KRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPR 300

Query: 301 SGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLH 360
           SGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLH
Sbjct: 301 SGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLH 360

Query: 361 SPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVEL 420
           SPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVEL
Sbjct: 361 SPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVEL 420

Query: 421 TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLG 480
           TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLG
Sbjct: 421 TVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLG 480

Query: 481 PLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLH 540
           PLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLH
Sbjct: 481 PLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLH 540

Query: 541 AAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA 600
           AAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA
Sbjct: 541 AAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKA 600

Query: 601 QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL 660
           QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL
Sbjct: 601 QVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL 660

Query: 661 AAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQ 720
           AAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQ
Sbjct: 661 AAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQ 720

Query: 721 AGRPSS 726
           AGRPSS
Sbjct: 721 AGRPSS 726


>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
           sapiens]
          Length = 782

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 7/146 (4%)

Query: 535 GFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDA 594
           G + LH AAA G   V+RLLL+AG DP ++D     P   AA     +  R   E     
Sbjct: 227 GASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGM 286

Query: 595 YDYNKA-QVPGPLT-PEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAA- 651
                A Q P  L   E+ +      R+Q+  R Q+E  Q R QE +     + RR +  
Sbjct: 287 DSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVC 346

Query: 652 -LSDREK---RALAAERRLAAQLGAP 673
            LS REK   + L+ ERR     G P
Sbjct: 347 RLSSREKISLQDLSKERRPGGAGGPP 372



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 39/148 (26%), Positives = 56/148 (37%), Gaps = 16/148 (10%)

Query: 499 LAACRAGDVGVLKLQLAPS---------PADPRVLSLLSAPLGSGGFTLLHAAAAAGRGS 549
           LAAC  GD+   +L L  +         PA P     +     + G + LH A       
Sbjct: 56  LAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLE 115

Query: 550 VVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNK-AQVPGPLTP 608
           VVR L+E GA     D+    P  VAA     +  R  +    +    N    +P  L  
Sbjct: 116 VVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAE 175

Query: 609 E------MEARQATRKREQKAARRQREE 630
                  ++A  A R  + +AA+R  EE
Sbjct: 176 SDAMEGLLKAEIARRGVDVEAAKRAEEE 203


>gi|10863929 ribonuclease L [Homo sapiens]
          Length = 741

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 40/140 (28%), Positives = 64/140 (45%), Gaps = 5/140 (3%)

Query: 534 GGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPD 593
           GG+T LH A    R  +V LLL  GADP ++      P+ +AA   +    + F+ K  D
Sbjct: 58  GGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGAD 117

Query: 594 AYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALS 653
               N+    G  T  MEA    + +  K   ++      R++ +E++ER  +    AL 
Sbjct: 118 V---NECDFYG-FTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALM 173

Query: 654 D-REKRALAAERRLAAQLGA 672
           D  EK  +   + L  ++GA
Sbjct: 174 DAAEKGHVEVLKILLDEMGA 193



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 30/97 (30%), Positives = 45/97 (46%), Gaps = 9/97 (9%)

Query: 497 ALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSV---VRL 553
           AL+ A   G V VLK+ L    AD      ++A    G   L+HA  ++    V     L
Sbjct: 171 ALMDAAEKGHVEVLKILLDEMGAD------VNACDNMGRNALIHALLSSDDSDVEAITHL 224

Query: 554 LLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEK 590
           LL+ GAD  V+  R + P  +A +K      +R +E+
Sbjct: 225 LLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ 261


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 25/58 (43%), Positives = 38/58 (65%), Gaps = 2/58 (3%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSD--REKRALAAERRL 666
           EA++   +REQ+   ++R EQ++R+QE+ E+ER EQ R  A  +  RE+  L AER L
Sbjct: 680 EAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAEREL 737



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 14/103 (13%)

Query: 581 RNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEE 640
           R    +  E+     +   AQ+        E R A  K ++KAA ++ EE + R++++EE
Sbjct: 585 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 644

Query: 641 RER-------EEQRRFAALSDREK-------RALAAERRLAAQ 669
             R       EE+RR   L  ++K       R  A  +RLA Q
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQ 687



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 17/57 (29%), Positives = 32/57 (56%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
           E E  +  +  E K    QRE++++ Q+ +E+  RE++RR     ++E++    ERR
Sbjct: 669 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 725



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 21/59 (35%), Positives = 33/59 (55%), Gaps = 6/59 (10%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQ 669
           E ++  RK  +     ++ EQ++R+QE+ E+ER EQ R      RE+     ER+LA Q
Sbjct: 670 EEQERLRKAAEAKRLAEQREQERREQERREQERREQER------REQERREQERQLAEQ 722



 Score = 37.0 bits (84), Expect = 0.065
 Identities = 16/62 (25%), Positives = 35/62 (56%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAA 668
           E E R+  R+ +++  + +RE+++Q  +++  RE+E  +    L +REK     + +L  
Sbjct: 694 EQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR 753

Query: 669 QL 670
           +L
Sbjct: 754 EL 755



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 25/99 (25%), Positives = 48/99 (48%), Gaps = 7/99 (7%)

Query: 578 KSTRNEFRRFMEKNPDAYDYNKAQVPGP---LTPEMEARQATRKREQKAAR----RQREE 630
           K    +F +  EK   A +   A+          +ME  +A RK+E++A R    +Q EE
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656

Query: 631 QQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQ 669
           +++ Q+  ++++ EEQ R    ++ ++ A   E+    Q
Sbjct: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 695



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 22/61 (36%), Positives = 38/61 (62%), Gaps = 2/61 (3%)

Query: 609 EMEARQATRK-REQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLA 667
           E E  QA R+ +E++ A R ++EQ QR+ E E++++EEQ+R A    +E++   A+    
Sbjct: 727 EQERLQAERELQEREKALRLQKEQLQRELE-EKKKKEEQQRLAERQLQEEQEKKAKEAAG 785

Query: 668 A 668
           A
Sbjct: 786 A 786



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 6/95 (6%)

Query: 609 EMEARQATRKREQKAARRQREEQQQR-----QQEQEEREREEQRRFAALSDREKRALAAE 663
           E +  +  R+REQ+  + +RE Q++      Q+EQ +RE EE+++        +R L  E
Sbjct: 716 ERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775

Query: 664 RRLAAQLGAPTSPIPDSAI-VNTRRCWSCGASLQG 697
           +   A+  A  S   +  + V +  C S   + QG
Sbjct: 776 QEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG 810



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 47/190 (24%), Positives = 72/190 (37%), Gaps = 24/190 (12%)

Query: 298 APRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAV 357
           APRS    F   +  PL R DP+           +F E +R   +L  L   EE   E +
Sbjct: 511 APRSVMKSFIK-RNTPL-RMDPKC----------SFVEKER--QRLENLRRKEE--AEQL 554

Query: 358 RLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQ--------GSGSEGED 409
           R    +   +   EE K   EE +RK+ +  +      EE  KQ           +E   
Sbjct: 555 RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614

Query: 410 GFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPST 469
             ++  E  +       + E E   K+    R  +   +++E   H+ LLQ+ +EEE   
Sbjct: 615 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 674

Query: 470 QSSQAVAAPL 479
               A A  L
Sbjct: 675 LRKAAEAKRL 684



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 16/68 (23%), Positives = 33/68 (48%)

Query: 599 KAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKR 658
           K   P  + P+    +  R+R +   R++  EQ +RQ+ +E++ R  +       +R ++
Sbjct: 521 KRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRK 580

Query: 659 ALAAERRL 666
            L A  R+
Sbjct: 581 VLQARERV 588



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 19/70 (27%), Positives = 37/70 (52%), Gaps = 11/70 (15%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQE----EREREEQRRFAALSD-------REK 657
           E E R+  R+ +++  + ++  +Q+R++EQE    ERE +E+ +   L          EK
Sbjct: 699 EQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 758

Query: 658 RALAAERRLA 667
           +    ++RLA
Sbjct: 759 KKKEEQQRLA 768


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 25/58 (43%), Positives = 38/58 (65%), Gaps = 2/58 (3%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSD--REKRALAAERRL 666
           EA++   +REQ+   ++R EQ++R+QE+ E+ER EQ R  A  +  RE+  L AER L
Sbjct: 676 EAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAEREL 733



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 14/103 (13%)

Query: 581 RNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEE 640
           R    +  E+     +   AQ+        E R A  K ++KAA ++ EE + R++++EE
Sbjct: 581 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 640

Query: 641 RER-------EEQRRFAALSDREK-------RALAAERRLAAQ 669
             R       EE+RR   L  ++K       R  A  +RLA Q
Sbjct: 641 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQ 683



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 17/57 (29%), Positives = 32/57 (56%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
           E E  +  +  E K    QRE++++ Q+ +E+  RE++RR     ++E++    ERR
Sbjct: 665 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 21/59 (35%), Positives = 33/59 (55%), Gaps = 6/59 (10%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQ 669
           E ++  RK  +     ++ EQ++R+QE+ E+ER EQ R      RE+     ER+LA Q
Sbjct: 666 EEQERLRKAAEAKRLAEQREQERREQERREQERREQER------REQERREQERQLAEQ 718



 Score = 37.0 bits (84), Expect = 0.065
 Identities = 16/62 (25%), Positives = 35/62 (56%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAA 668
           E E R+  R+ +++  + +RE+++Q  +++  RE+E  +    L +REK     + +L  
Sbjct: 690 EQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR 749

Query: 669 QL 670
           +L
Sbjct: 750 EL 751



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 25/99 (25%), Positives = 48/99 (48%), Gaps = 7/99 (7%)

Query: 578 KSTRNEFRRFMEKNPDAYDYNKAQVPGP---LTPEMEARQATRKREQKAAR----RQREE 630
           K    +F +  EK   A +   A+          +ME  +A RK+E++A R    +Q EE
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652

Query: 631 QQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQ 669
           +++ Q+  ++++ EEQ R    ++ ++ A   E+    Q
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 691



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 22/61 (36%), Positives = 38/61 (62%), Gaps = 2/61 (3%)

Query: 609 EMEARQATRK-REQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLA 667
           E E  QA R+ +E++ A R ++EQ QR+ E E++++EEQ+R A    +E++   A+    
Sbjct: 723 EQERLQAERELQEREKALRLQKEQLQRELE-EKKKKEEQQRLAERQLQEEQEKKAKEAAG 781

Query: 668 A 668
           A
Sbjct: 782 A 782



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 6/95 (6%)

Query: 609 EMEARQATRKREQKAARRQREEQQQR-----QQEQEEREREEQRRFAALSDREKRALAAE 663
           E +  +  R+REQ+  + +RE Q++      Q+EQ +RE EE+++        +R L  E
Sbjct: 712 ERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 771

Query: 664 RRLAAQLGAPTSPIPDSAI-VNTRRCWSCGASLQG 697
           +   A+  A  S   +  + V +  C S   + QG
Sbjct: 772 QEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG 806



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 14/57 (24%), Positives = 31/57 (54%)

Query: 610 MEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           M+ ++  R+R +   R++  EQ +RQ+ +E++ R  +       +R ++ L A  R+
Sbjct: 528 MDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV 584



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 28/117 (23%), Positives = 45/117 (38%), Gaps = 8/117 (6%)

Query: 371 EERKKPTEEEIRKICRDEKEALGQNEESPKQ--------GSGSEGEDGFQVELELVELTV 422
           EE K   EE +RK+ +  +      EE  KQ           +E     ++  E  +   
Sbjct: 564 EEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKA 623

Query: 423 GTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPL 479
               + E E   K+    R  +   +++E   H+ LLQ+ +EEE       A A  L
Sbjct: 624 AAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRL 680



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 19/70 (27%), Positives = 37/70 (52%), Gaps = 11/70 (15%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQE----EREREEQRRFAALSD-------REK 657
           E E R+  R+ +++  + ++  +Q+R++EQE    ERE +E+ +   L          EK
Sbjct: 695 EQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 754

Query: 658 RALAAERRLA 667
           +    ++RLA
Sbjct: 755 KKKEEQQRLA 764


>gi|6912326 family with sequence similarity 50, member B [Homo
           sapiens]
          Length = 325

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 37/85 (43%), Positives = 52/85 (61%), Gaps = 15/85 (17%)

Query: 609 EMEARQAT--RKREQKAARRQREE----QQQRQQEQEEREREEQRRFAALS----DREKR 658
           +M+ARQ    R+RE++ A+RQ  E    QQ+RQ+EQE+R RE +R+ + LS    D + +
Sbjct: 72  DMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQR-RERKRKISCLSFALDDLDDQ 130

Query: 659 ALAAERRLAAQLG----APTSPIPD 679
           A AAE R A  LG      TS +PD
Sbjct: 131 ADAAEARRAGNLGKNPDVDTSFLPD 155


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 27/84 (32%), Positives = 49/84 (58%), Gaps = 2/84 (2%)

Query: 585 RRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEERERE 644
           RRF+     A  + K Q+ G +   +  +    KREQ+  ++Q EE++++++E+EERERE
Sbjct: 783 RRFLHLKKAAIVFQK-QLRGQIARRVYRQLLAEKREQEEKKKQ-EEEEKKKREEEERERE 840

Query: 645 EQRRFAALSDREKRALAAERRLAA 668
            +RR A L  +++     ++ L A
Sbjct: 841 RERREAELRAQQEEETRKQQELEA 864



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 14/49 (28%), Positives = 27/49 (55%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRA 659
           +  +  +KRE++   R+RE ++   + Q+E E  +Q+   AL   +K A
Sbjct: 824 QEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEA 872



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 16/66 (24%), Positives = 34/66 (51%)

Query: 581 RNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEE 640
           R  +R+ + +  +  +  K +       E E R+  R+R +   R Q+EE+ ++QQE E 
Sbjct: 805 RRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEA 864

Query: 641 REREEQ 646
            ++ ++
Sbjct: 865 LQKSQK 870



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 29/110 (26%), Positives = 53/110 (48%), Gaps = 8/110 (7%)

Query: 337 QRVLHKLTTLHVYEEDPREAV--RLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQ 394
           +R LH      V+++  R  +  R++      K  +EE+KK  EEE +K   +E+E   +
Sbjct: 783 RRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERE 842

Query: 395 NEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKK 444
             E+  +    E E   Q ELE ++ +       E+E+  +  ++K NK+
Sbjct: 843 RREAELRAQ-QEEETRKQQELEALQKSQK-----EAELTRELEKQKENKQ 886



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 28/99 (28%), Positives = 44/99 (44%), Gaps = 4/99 (4%)

Query: 599 KAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQ--RRFAALSDRE 656
           K+Q    LT E+E ++  ++ E+     +  E  QR +EQ+E    E   ++     D+E
Sbjct: 867 KSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQE 926

Query: 657 KRALAAERRLAAQ--LGAPTSPIPDSAIVNTRRCWSCGA 693
            R L  E   AAQ  L +      D  + N  R  S G+
Sbjct: 927 LRRLEEEACRAAQEFLESLNFDEIDECVRNIERSLSVGS 965


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 82/363 (22%), Positives = 142/363 (39%), Gaps = 64/363 (17%)

Query: 334 QELQRVLHKLTTLHVYEEDPREAVRLHSPQTH-WKTVREERKKPTEEEIRKICRDEKEAL 392
           +++Q++  KL      +E+  E +RLH  +     ++RE  +K  EEE  ++  +E + L
Sbjct: 616 EKMQQLREKLC-----QEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRL 670

Query: 393 GQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEA 452
                +  Q S    ED  + E E                L K R    ++++  R    
Sbjct: 671 SWLR-AQVQSSTQADEDQIRAEQEAS--------------LQKLREELESQQKAERASLE 715

Query: 453 GAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKL 512
             +R +L+Q +EE  +++ S+  A      L+ AK     +L   L    +     V  L
Sbjct: 716 QKNRQMLEQLKEEIEASEKSEQAA------LNAAKEKALQQLREQLEGERKEA---VATL 766

Query: 513 QLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPY 572
           +   S    R+ S L A       +L      A +    +L    G    V+    +  Y
Sbjct: 767 EKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQ---VEHRVHQKSY 823

Query: 573 TVAADK-----------------------STRNEFRRFMEKNPDAYDYN----KAQVPGP 605
            VA  +                         + E ++ M K  + Y+      +A++ G 
Sbjct: 824 HVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGH 883

Query: 606 LTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALS-DREKRALAAER 664
           LT E+E  Q   +RE +     R+EQ +R ++   R RE++R+   L  D E RA   + 
Sbjct: 884 LTGELERLQRAHERELETV---RQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKA 940

Query: 665 RLA 667
           RLA
Sbjct: 941 RLA 943



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 5/62 (8%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQL 670
           E  +A+ K EQ A    +E+  Q+ +EQ E ER+E     A++  EK   A   RL + L
Sbjct: 727 EEIEASEKSEQAALNAAKEKALQQLREQLEGERKE-----AVATLEKEHSAELERLCSSL 781

Query: 671 GA 672
            A
Sbjct: 782 EA 783


>gi|239745093 PREDICTED: hypothetical protein XP_002343359 [Homo
           sapiens]
          Length = 142

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 17/106 (16%)

Query: 561 PTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKRE 620
           PT++ S A      +A KS R E +R  EK  +                 E ++   KR 
Sbjct: 51  PTLRHSMAG----TSARKSQRREEKRREEKRREE-------------KRREEKRREGKRR 93

Query: 621 QKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           +K   ++ EE+++ ++E+EE E EE+    +L+ RE+     E+RL
Sbjct: 94  EKEEEKEEEEEEEEEEEEEEEEEEEEEVSFSLATRERETETEEKRL 139



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 12/59 (20%), Positives = 32/59 (54%)

Query: 588 MEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQ 646
           +++ P    ++ A      +   E ++   KR ++  R ++  + +R++++EE+E EE+
Sbjct: 46  VKEEPPTLRHSMAGTSARKSQRREEKRREEKRREEKRREEKRREGKRREKEEEKEEEEE 104


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 25/71 (35%), Positives = 41/71 (57%), Gaps = 2/71 (2%)

Query: 599 KAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKR 658
           K Q+       +E ++  R+R ++  RR+RE ++Q+++EQ  RE+EE+RR   L  R K 
Sbjct: 388 KRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKE 447

Query: 659 ALAAERRLAAQ 669
               ERR A +
Sbjct: 448 --EEERRRAEE 456



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 19/58 (32%), Positives = 35/58 (60%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           E   R   ++R ++ ARRQ+E +Q+R++++E+R  EE  R     +  +RA   +RR+
Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 30/97 (30%), Positives = 50/97 (51%), Gaps = 12/97 (12%)

Query: 574 VAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEAR-QATRKREQKAARRQREEQQ 632
           V  + + R +F R  ++N +  +  + Q    L  E + R Q   KR+  A R++R EQQ
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQ---QLLQEQQLREQEEYKRQLLAERQKRIEQQ 402

Query: 633 QRQ----QEQEEREREEQRRFAALSDREKRALAAERR 665
           + Q    +EQ+ RERE +R+     +RE+R    E +
Sbjct: 403 KEQRRRLEEQQRREREARRQ----QEREQRRREQEEK 435



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 21/58 (36%), Positives = 38/58 (65%), Gaps = 5/58 (8%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEERER--EEQRRFAALSDREKRALAAER 664
           E + R+   +R+Q+  +R+RE++++R+ E+ ER R  EE+RR A   + EKR +  E+
Sbjct: 411 EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA---EEEKRRVEREQ 465



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 23/62 (37%), Positives = 36/62 (58%), Gaps = 5/62 (8%)

Query: 609 EMEARQAT----RKREQKAARRQREEQQQRQQEQEERE-REEQRRFAALSDREKRALAAE 663
           E EAR+      R+REQ+  RR  E +++R++E+E R   EE+RR     +  +R L  E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE 475

Query: 664 RR 665
           +R
Sbjct: 476 QR 477



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 16/85 (18%)

Query: 589 EKNPDAYDYNKAQVPGPLTPEMEA---------------RQATRKREQKAARRQREEQQQ 633
           EK+   Y+Y+ ++      PE E                R   R +++   R +   +QQ
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ 374

Query: 634 RQQEQEEREREEQRRFAALSDREKR 658
             QEQ+ RE+EE +R   L++R+KR
Sbjct: 375 LLQEQQLREQEEYKR-QLLAERQKR 398



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 14/48 (29%), Positives = 27/48 (56%)

Query: 613 RQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL 660
           ++  R+ E+   RR+ EE+++R +E++ R   EQ       + E+R L
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL 479


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 25/71 (35%), Positives = 41/71 (57%), Gaps = 2/71 (2%)

Query: 599 KAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKR 658
           K Q+       +E ++  R+R ++  RR+RE ++Q+++EQ  RE+EE+RR   L  R K 
Sbjct: 388 KRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKE 447

Query: 659 ALAAERRLAAQ 669
               ERR A +
Sbjct: 448 --EEERRRAEE 456



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 19/58 (32%), Positives = 35/58 (60%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           E   R   ++R ++ ARRQ+E +Q+R++++E+R  EE  R     +  +RA   +RR+
Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 30/97 (30%), Positives = 50/97 (51%), Gaps = 12/97 (12%)

Query: 574 VAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEAR-QATRKREQKAARRQREEQQ 632
           V  + + R +F R  ++N +  +  + Q    L  E + R Q   KR+  A R++R EQQ
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQ---QLLQEQQLREQEEYKRQLLAERQKRIEQQ 402

Query: 633 QRQ----QEQEEREREEQRRFAALSDREKRALAAERR 665
           + Q    +EQ+ RERE +R+     +RE+R    E +
Sbjct: 403 KEQRRRLEEQQRREREARRQ----QEREQRRREQEEK 435



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 21/58 (36%), Positives = 38/58 (65%), Gaps = 5/58 (8%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEERER--EEQRRFAALSDREKRALAAER 664
           E + R+   +R+Q+  +R+RE++++R+ E+ ER R  EE+RR A   + EKR +  E+
Sbjct: 411 EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA---EEEKRRVEREQ 465



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 23/62 (37%), Positives = 36/62 (58%), Gaps = 5/62 (8%)

Query: 609 EMEARQAT----RKREQKAARRQREEQQQRQQEQEERE-REEQRRFAALSDREKRALAAE 663
           E EAR+      R+REQ+  RR  E +++R++E+E R   EE+RR     +  +R L  E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE 475

Query: 664 RR 665
           +R
Sbjct: 476 QR 477



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 16/85 (18%)

Query: 589 EKNPDAYDYNKAQVPGPLTPEMEA---------------RQATRKREQKAARRQREEQQQ 633
           EK+   Y+Y+ ++      PE E                R   R +++   R +   +QQ
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ 374

Query: 634 RQQEQEEREREEQRRFAALSDREKR 658
             QEQ+ RE+EE +R   L++R+KR
Sbjct: 375 LLQEQQLREQEEYKR-QLLAERQKR 398



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 14/48 (29%), Positives = 27/48 (56%)

Query: 613 RQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL 660
           ++  R+ E+   RR+ EE+++R +E++ R   EQ       + E+R L
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL 479


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 25/71 (35%), Positives = 41/71 (57%), Gaps = 2/71 (2%)

Query: 599 KAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKR 658
           K Q+       +E ++  R+R ++  RR+RE ++Q+++EQ  RE+EE+RR   L  R K 
Sbjct: 388 KRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKE 447

Query: 659 ALAAERRLAAQ 669
               ERR A +
Sbjct: 448 --EEERRRAEE 456



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 19/58 (32%), Positives = 35/58 (60%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           E   R   ++R ++ ARRQ+E +Q+R++++E+R  EE  R     +  +RA   +RR+
Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRV 461



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 30/97 (30%), Positives = 50/97 (51%), Gaps = 12/97 (12%)

Query: 574 VAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEAR-QATRKREQKAARRQREEQQ 632
           V  + + R +F R  ++N +  +  + Q    L  E + R Q   KR+  A R++R EQQ
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQ---QLLQEQQLREQEEYKRQLLAERQKRIEQQ 402

Query: 633 QRQ----QEQEEREREEQRRFAALSDREKRALAAERR 665
           + Q    +EQ+ RERE +R+     +RE+R    E +
Sbjct: 403 KEQRRRLEEQQRREREARRQ----QEREQRRREQEEK 435



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 21/58 (36%), Positives = 38/58 (65%), Gaps = 5/58 (8%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEERER--EEQRRFAALSDREKRALAAER 664
           E + R+   +R+Q+  +R+RE++++R+ E+ ER R  EE+RR A   + EKR +  E+
Sbjct: 411 EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA---EEEKRRVEREQ 465



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 23/62 (37%), Positives = 36/62 (58%), Gaps = 5/62 (8%)

Query: 609 EMEARQAT----RKREQKAARRQREEQQQRQQEQEERE-REEQRRFAALSDREKRALAAE 663
           E EAR+      R+REQ+  RR  E +++R++E+E R   EE+RR     +  +R L  E
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEE 475

Query: 664 RR 665
           +R
Sbjct: 476 QR 477



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 24/85 (28%), Positives = 40/85 (47%), Gaps = 16/85 (18%)

Query: 589 EKNPDAYDYNKAQVPGPLTPEMEA---------------RQATRKREQKAARRQREEQQQ 633
           EK+   Y+Y+ ++      PE E                R   R +++   R +   +QQ
Sbjct: 315 EKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ 374

Query: 634 RQQEQEEREREEQRRFAALSDREKR 658
             QEQ+ RE+EE +R   L++R+KR
Sbjct: 375 LLQEQQLREQEEYKR-QLLAERQKR 398



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 14/48 (29%), Positives = 27/48 (56%)

Query: 613 RQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRAL 660
           ++  R+ E+   RR+ EE+++R +E++ R   EQ       + E+R L
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHL 479


>gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo
           sapiens]
          Length = 528

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 21/56 (37%), Positives = 36/56 (64%), Gaps = 1/56 (1%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAER 664
           E E ++  RK E++  RR+ EE+++ Q+E+E+R REE+ R     + E+R +  ER
Sbjct: 182 EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRR-EEEERRRIEEER 236



 Score = 37.0 bits (84), Expect = 0.065
 Identities = 20/61 (32%), Positives = 35/61 (57%), Gaps = 3/61 (4%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAA 668
           E E R+  +K E+K   R+REE+++ ++E+EER R E+ R      +++   A   + A 
Sbjct: 200 EEEERERLQKEEEK---RRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAV 256

Query: 669 Q 669
           Q
Sbjct: 257 Q 257



 Score = 36.6 bits (83), Expect = 0.084
 Identities = 18/56 (32%), Positives = 34/56 (60%), Gaps = 1/56 (1%)

Query: 612 ARQATRKREQKAARRQREEQQQRQQEQEER-EREEQRRFAALSDREKRALAAERRL 666
           A     K EQ+  R++ EE+++R++E+ ER ++EE++R     +R +R     RR+
Sbjct: 177 ASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRI 232


>gi|15529978 zinc finger protein 622 [Homo sapiens]
          Length = 477

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 17/45 (37%), Positives = 29/45 (64%)

Query: 74  CSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQ 118
           C TC   F++   QR HYK DWHR+NL++++     ++A  F+++
Sbjct: 6   CITCRVAFRDADMQRAHYKTDWHRYNLRRKVASMAPVTAEGFQER 50


>gi|89941470 ankyrin repeat domain 34 [Homo sapiens]
          Length = 496

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 35/115 (30%), Positives = 49/115 (42%), Gaps = 15/115 (13%)

Query: 480 GPLLDEAKAPGQPELWNALLAACRAG-----DVGVLKLQLAPSPADPRVLSLLSAPLGSG 534
           G  ++E  A G+     AL+AACRA      +   +   L    ADP +   L      G
Sbjct: 28  GAYVNEGDAQGE----TALMAACRARYDDPQNKARMVRYLLEQGADPNIADRL------G 77

Query: 535 GFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFME 589
              L+HA A  G  +V  LLL  GADP+V+D         A D+  R      ++
Sbjct: 78  RTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLD 132


>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
          Length = 1123

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/168 (25%), Positives = 77/168 (45%), Gaps = 18/168 (10%)

Query: 551 VRLLLEAGADPTVQDSRARPPYTVAADKSTRNE---FRRFMEKNPDAYDYNKAQVPGPLT 607
           +R  L    DPT+++ + +        +    +   F  F +++      ++ Q+   L 
Sbjct: 60  LRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLK 119

Query: 608 PEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRR----FAALSDREKRALAA- 662
            + E   A +++E  AA+RQ+E +QQRQ+EQ+ +E  E++R       L ++EK   +A 
Sbjct: 120 QQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAI 179

Query: 663 ---ERRLAAQ---LGAPTSPIP---DSAIVNTRRCWSC-GASLQGLTP 700
              E +L  Q   L     P P   + ++    +CW    ASL   +P
Sbjct: 180 ASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSP 227


>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
          Length = 1122

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 42/168 (25%), Positives = 77/168 (45%), Gaps = 18/168 (10%)

Query: 551 VRLLLEAGADPTVQDSRARPPYTVAADKSTRNE---FRRFMEKNPDAYDYNKAQVPGPLT 607
           +R  L    DPT+++ + +        +    +   F  F +++      ++ Q+   L 
Sbjct: 59  LRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLK 118

Query: 608 PEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRR----FAALSDREKRALAA- 662
            + E   A +++E  AA+RQ+E +QQRQ+EQ+ +E  E++R       L ++EK   +A 
Sbjct: 119 QQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAI 178

Query: 663 ---ERRLAAQ---LGAPTSPIP---DSAIVNTRRCWSC-GASLQGLTP 700
              E +L  Q   L     P P   + ++    +CW    ASL   +P
Sbjct: 179 ASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSP 226


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 60/264 (22%), Positives = 112/264 (42%), Gaps = 27/264 (10%)

Query: 452 AGAHRTLLQQTQEE-EPSTQSSQAVAAP-LGPLLDEAKAPGQPELWNALLAACRAGDVGV 509
           AGA   ++ +T  E  PS +   +   P +  L+ +      P + NA  +     +   
Sbjct: 11  AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPES 70

Query: 510 LKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRAR 569
              Q+ P PA P+  S               ++ A  RG     +    A P  + S+  
Sbjct: 71  PSGQVGPRPAPPQEES--------------PSSEAKSRGPTPPAMGPRDARPPRRSSQPS 116

Query: 570 PPYTVAADKS-TRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQAT--RKREQKAARR 626
           P    A+D   T+ E ++  E++  A +  + +        + A++A    K E+  A R
Sbjct: 117 PTAVPASDSPPTKQEVKKAGERHKLAKERREERAK-----YLAAKKAVWLEKEEKAKALR 171

Query: 627 QREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTR 686
           +++ Q++R++ +E+R + EQRR AAL +R+++ L  E+       A    +  +     +
Sbjct: 172 EKQLQERRRRLEEQRLKAEQRR-AALEERQRQKL--EKNKERYEAAIQRSVKKTWAEIRQ 228

Query: 687 RCWSCGASLQGLTPFHYLDFSFCS 710
           + WS   +L   +P H    S CS
Sbjct: 229 QRWSWAGALHHSSPGHKTSGSRCS 252



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 54/247 (21%), Positives = 96/247 (38%), Gaps = 37/247 (14%)

Query: 434 PKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPL-GPLLDEAKAPGQP 492
           PK R R+   KE++++  + A      Q++    + + S A A+P   P      AP Q 
Sbjct: 504 PKGRVRR---KEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQK 560

Query: 493 ELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVR 552
           E   A        D  VL    AP+P         S P+          A    R    R
Sbjct: 561 EQPPAETPT----DAAVLTSPPAPAPPVTP-----SKPM----------AGTTDREEATR 601

Query: 553 LLLEAGADPTVQDSRARPPYTVAADKSTR-------NEFRRFMEKNPDAYDYNKAQVPGP 605
           LL E       Q  R      + A++  R        E     E+  +A    + +    
Sbjct: 602 LLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREK 661

Query: 606 LTPEMEARQATRKREQKAARRQREEQQQRQ-------QEQEEREREEQRRFAALSDREKR 658
              E E ++  +K++++A  R REE ++++       Q+QE+  +E ++R   +  R ++
Sbjct: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRK 721

Query: 659 ALAAERR 665
           +  +E +
Sbjct: 722 SEVSETK 728



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 20/66 (30%), Positives = 33/66 (50%), Gaps = 8/66 (12%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQL 670
           E R+          RR+ E    +++E++++ERE        +++EK ALA ER L  + 
Sbjct: 390 ERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERE--------NEKEKSALARERSLKKRQ 441

Query: 671 GAPTSP 676
             P SP
Sbjct: 442 SLPASP 447


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 41/121 (33%), Positives = 48/121 (39%), Gaps = 11/121 (9%)

Query: 459  LQQTQEEEPSTQSSQAVAAPLGPLLD-EAKAPGQPELWN--ALLAACRAGDVGVLKLQLA 515
            LQQ      S   S  V   LG   + E +  G   LW   AL AA   G + V +L L 
Sbjct: 1033 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLG 1092

Query: 516  PSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVA 575
               A  R            G   L  AA  G   +VRLLLE G D  + D + R P  VA
Sbjct: 1093 HGAAVSRT--------NRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVA 1144

Query: 576  A 576
            A
Sbjct: 1145 A 1145


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 41/121 (33%), Positives = 48/121 (39%), Gaps = 11/121 (9%)

Query: 459  LQQTQEEEPSTQSSQAVAAPLGPLLD-EAKAPGQPELWN--ALLAACRAGDVGVLKLQLA 515
            LQQ      S   S  V   LG   + E +  G   LW   AL AA   G + V +L L 
Sbjct: 1041 LQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLG 1100

Query: 516  PSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVA 575
               A  R            G   L  AA  G   +VRLLLE G D  + D + R P  VA
Sbjct: 1101 HGAAVSRT--------NRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVA 1152

Query: 576  A 576
            A
Sbjct: 1153 A 1153


>gi|239743649 PREDICTED: IQ motif and ankyrin repeat
           domain-containing protein LOC642574 [Homo sapiens]
          Length = 580

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 49/186 (26%), Positives = 75/186 (40%), Gaps = 18/186 (9%)

Query: 496 NALLAACRAGD-------VGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRG 548
           +A    C AGD       +G  +L+      DPR       P   G   +  + AA+  G
Sbjct: 6   SAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCG 65

Query: 549 SVVR--LLLEAGADPT--VQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPG 604
              R   L  AG   +   +D  AR           R E  R  E+  +  +  +     
Sbjct: 66  LCGREPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQME----- 120

Query: 605 PLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAER 664
             TP+ EA  A  +REQ+AARR RE+++  Q+E+ E  +  +R   A  D +   + A  
Sbjct: 121 --TPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVL 178

Query: 665 RLAAQL 670
           +   QL
Sbjct: 179 KEVEQL 184



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 61/244 (25%), Positives = 97/244 (39%), Gaps = 39/244 (15%)

Query: 438 RRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSS--------QAVAAPLGPLLDEAKAP 489
           RR++    + R+QE  A R   ++ Q       ++        +AV   +  LL   +  
Sbjct: 132 RREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTR-EGV 190

Query: 490 GQPELWNA-------LLAACRAGDVGVLKLQLAPSPADPRVLSLLS----APLGSGGF-- 536
           G  E   A        LA C     G   L  A +   P  + L +    +P   G F  
Sbjct: 191 GHDEAGEARRLQRRVALAECE-DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGP 249

Query: 537 TLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYD 596
           T L+ AA  G  + V +LL+ GADP V       P  VA+  +  +  R        ++D
Sbjct: 250 TPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR--------SWD 301

Query: 597 YNKAQVPGPLTPEMEARQATRKRE-----QKAARRQREEQQQRQQEQEEREREEQRRFAA 651
            +  +    +   MEA Q  R +E     +  A R   + QQ  +EQ++  +E Q+ +  
Sbjct: 302 LSLTEA---MLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCE 358

Query: 652 LSDR 655
           LS R
Sbjct: 359 LSRR 362


>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
           isoform 2 [Homo sapiens]
          Length = 318

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 32/80 (40%), Positives = 42/80 (52%), Gaps = 18/80 (22%)

Query: 492 PELWNALL--AACRAGDVGVLKLQL----APSPADPRVLSLLSAPLGSGGFTLLHAAAAA 545
           PEL   L   AA  AGDV  ++  L    +P+  D            + G+TLLH +AA 
Sbjct: 10  PELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRD------------ANGWTLLHFSAAR 57

Query: 546 GRGSVVRLLLEAGADPTVQD 565
           G+   VR+ LE GADPTV+D
Sbjct: 58  GKERCVRVFLEHGADPTVKD 77



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 32/120 (26%), Positives = 55/120 (45%), Gaps = 13/120 (10%)

Query: 460 QQTQEEEPSTQSSQAVAA----PLGPLLDEAKAPGQPEL--WNALLAACRAGDVGVLKLQ 513
           ++  E +   Q   AVAA     +  +L++  +P   +   W  L  +   G    +++ 
Sbjct: 7   RRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVF 66

Query: 514 LAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYT 573
           L    ADP V  L+      GGFT LH AA  GR  + RL+LE+     + ++++   +T
Sbjct: 67  LEHG-ADPTVKDLI------GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWT 119



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 18/41 (43%), Positives = 22/41 (53%)

Query: 535 GFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVA 575
           G+T LH AA  GR S VRLLLE  A+      +   P  +A
Sbjct: 117 GWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 22/55 (40%), Positives = 36/55 (65%), Gaps = 4/55 (7%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
           E R+  ++ EQ+  R +RE+Q +R+QE+E RE++E+RR      +E+R    ERR
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR----EQQERREQQEERR 335



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 26/75 (34%), Positives = 41/75 (54%), Gaps = 9/75 (12%)

Query: 597  YNKAQVPGPLTPEMEARQATRK------REQKAARRQREEQQQRQQEQEEREREEQRRFA 650
            Y K      L PE E +Q  R+      RE++  R++REEQQ R QE + + REE++   
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ--- 1802

Query: 651  ALSDREKRALAAERR 665
               +RE++ L  ++R
Sbjct: 1803 LRQEREEQQLRPQQR 1817



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 25/71 (35%), Positives = 35/71 (49%), Gaps = 14/71 (19%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEERER--------------EEQRRFAALSD 654
           E E R+   +REQ+  R Q E ++QR + QEE ER              +E+RR   L  
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552

Query: 655 REKRALAAERR 665
            E++ L  ERR
Sbjct: 553 EEEKRLEQERR 563



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 21/60 (35%), Positives = 37/60 (61%), Gaps = 2/60 (3%)

Query: 609 EMEARQATRKREQKAARRQREE--QQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           + E R+   +R ++  RR++EE  +QQ ++EQEE  RE+Q R     +R ++ L  E++L
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 19/54 (35%), Positives = 32/54 (59%)

Query: 611  EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAER 664
            E  Q  R+ +++A RR R+ Q+++Q  +EERE + +R+      RE+  L  ER
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER 1348



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 23/85 (27%), Positives = 47/85 (55%), Gaps = 8/85 (9%)

Query: 585  RRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEERERE 644
            R+F+E+ P      + Q       ++   +  + RE++   ++ EEQQ R+QE++ + RE
Sbjct: 1643 RKFLEEEPQLRRQEREQ-------QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695

Query: 645  EQRRFAALSDREKRALAAERRLAAQ 669
            E+++     +RE++ L  E++L  Q
Sbjct: 1696 EEQQLRR-QERERKFLQEEQQLRRQ 1719



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 22/59 (37%), Positives = 38/59 (64%), Gaps = 5/59 (8%)

Query: 611 EARQATRKREQKAARRQ---REEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           E R+   +REQ+  R Q   RE++++R+++Q  RE+EE+RR   L  R ++ L  E++L
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL--RREQQLRREQQL 389



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 9/71 (12%)

Query: 609 EMEARQATRKREQKAARRQR---------EEQQQRQQEQEEREREEQRRFAALSDREKRA 659
           E E R+   KR+Q+  RR+R          EQQ+R+++Q  RE+EE+R        E+  
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527

Query: 660 LAAERRLAAQL 670
           L    R   QL
Sbjct: 528 LQQRLRSEQQL 538



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 76/352 (21%), Positives = 138/352 (39%), Gaps = 40/352 (11%)

Query: 329 RRPTFQELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDE 388
           R+   + LQ+ L     L   +E+ RE +     +   +  R E++   E+E R+     
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR----- 575

Query: 389 KEALGQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKE--- 445
            + L + EE  +Q    E E+  +  L+  E+      L + E   +R +R+  ++E   
Sbjct: 576 DQLLKREEERRQQRLKREQEERLEQRLKREEVE----RLEQEERREQRLKREEPEEERRQ 631

Query: 446 ---KSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLL--DEAKAPGQPELWNALLA 500
              KS +QE    + L ++ QE        +     L   L  +  +   + EL      
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691

Query: 501 ACRA---GDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRG--SVVRLLL 555
             R      +   + QL  S AD R   + S P    G           R   S ++   
Sbjct: 692 QARERIKSRIPKWQWQLE-SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750

Query: 556 EAGADPTVQDSRARPPYT---VAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEA 612
           E  A    Q+   R  +T    A +KS R   R+ +   P            PL  + E 
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERG--RQRLSARP------------PLREQRER 796

Query: 613 RQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAER 664
           +    +R+Q+  R   EE+++ Q+ ++ RERE++ +F    ++ +R   A++
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 20/80 (25%), Positives = 43/80 (53%), Gaps = 2/80 (2%)

Query: 578 KSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQE 637
           K  R E RR  E+  +     + +    L  + E  +  ++ E++  + +RE+Q++R+++
Sbjct: 280 KLERQELRR--ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337

Query: 638 QEEREREEQRRFAALSDREK 657
           Q  RE+EE+R      ++E+
Sbjct: 338 QLRREQEERREQQLRREQEE 357



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 27/70 (38%), Positives = 40/70 (57%), Gaps = 8/70 (11%)

Query: 608 PEMEARQATRKREQKAARRQ----REEQQQRQQE---QEEREREEQR-RFAALSDREKRA 659
           PE E RQ   K E++  RRQ    RE+Q++R+Q    +EE ER EQR +     +R ++ 
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684

Query: 660 LAAERRLAAQ 669
           LA E +  A+
Sbjct: 685 LAEEEQEQAR 694



 Score = 37.4 bits (85), Expect = 0.050
 Identities = 85/383 (22%), Positives = 149/383 (38%), Gaps = 79/383 (20%)

Query: 314  LQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEE-----DPREAVRLHSP------ 362
            LQ+ + +L      TRR   QEL+R   K   L   EE     +P +  R          
Sbjct: 1056 LQQEEEQLLGEERETRRR--QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113

Query: 363  ----QTHWKTVREERKKPTEEEIRKICRDEKEALGQNE----ESPKQGSGSEGEDGFQVE 414
                Q   + +REER+K   +E+ +  R+E+E   + E    E P++    E E  ++ E
Sbjct: 1114 EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173

Query: 415  LELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQA 474
             EL +         E E L    R ++ K+ + R+++      L +Q +++    +  ++
Sbjct: 1174 EELQQ---------EEEQL---LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221

Query: 475  VAAPLGPLLDEAKAPGQPELWNALL---AACRAGDVGVLKLQLAPSPADPRVLSLLSAPL 531
                      + K   +PE  NA+      C+  +    + QL  S    R         
Sbjct: 1222 ----------DLKWQWEPEKENAVRDNKVYCKGRENEQFR-QLEDSQLRDR--------- 1261

Query: 532  GSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRA---RPPYTVAADKSTRNEFRRFM 588
                           +  +  LL E       Q+ R    R  +    ++  R E +   
Sbjct: 1262 -------------QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE-- 1306

Query: 589  EKNPDAYDYNKAQVPGPLTPEMEARQATRK--REQKAARRQREEQQQRQQEQEEREREEQ 646
             K  D     + Q+      E   RQ T +  RE++   ++REEQ  R+QE++ + REE+
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE 1366

Query: 647  RRFAALSDREKRALAAERRLAAQ 669
             R     ++ ++ L  E+RL  Q
Sbjct: 1367 LRH---QEQGRKFLEEEQRLRRQ 1386



 Score = 36.6 bits (83), Expect = 0.084
 Identities = 22/60 (36%), Positives = 36/60 (60%), Gaps = 10/60 (16%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQE-----QEEREREEQRRFAALSDREKRALAAERR 665
           E +Q  R R ++  RR++EE+++ QQE     QE RE++E+RR     +++ R    ERR
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR-----EQQLRREQEERR 347



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 22/56 (39%), Positives = 34/56 (60%), Gaps = 4/56 (7%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAER 664
           E E +Q   +REQ+  R+Q EE   R+++QEER RE+Q R     +R ++ L  E+
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEE---RREQQEER-REQQERREQQEERREQQLRREQ 343



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 19/62 (30%), Positives = 36/62 (58%), Gaps = 2/62 (3%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAA 668
           ++  +Q   +REQ+  RR  E+Q++R+Q++E RE++ +R      +++ R    E R   
Sbjct: 305 QLRRKQEEERREQQEERR--EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ 362

Query: 669 QL 670
           QL
Sbjct: 363 QL 364



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 24/86 (27%), Positives = 43/86 (50%), Gaps = 6/86 (6%)

Query: 606 LTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQ-----RRFAALSDREKRAL 660
           L  E   R+  +++EQ+    + EEQ ++Q+  E+R+R+ +     R+     +RE+R  
Sbjct: 129 LEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR- 187

Query: 661 AAERRLAAQLGAPTSPIPDSAIVNTR 686
           A E +L +  G  T   PD   +  R
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRR 213



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 19/52 (36%), Positives = 28/52 (53%)

Query: 613 RQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAER 664
           R+   +REQ+  R Q EE+ +++ EQE RE+  +R      D  KR    ER
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 19/62 (30%), Positives = 38/62 (61%), Gaps = 3/62 (4%)

Query: 607  TPEMEARQATRKR---EQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAE 663
            T + + R+  R R   E++  R +REEQQ R+QE++ + REE++      +++ R+  ++
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD 1794

Query: 664  RR 665
            R+
Sbjct: 1795 RK 1796



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 21/57 (36%), Positives = 34/57 (59%), Gaps = 5/57 (8%)

Query: 613 RQATRKREQKAARRQREE---QQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           R+   +REQ+  R Q EE   QQ R++++EER  ++ RR   L  R ++ L  E++L
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL--RREQQLRREQQL 395



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 25/65 (38%), Positives = 39/65 (60%), Gaps = 8/65 (12%)

Query: 609 EMEARQATRKREQKAARR--QREEQ-----QQRQQEQEEREREEQRRFAALS-DREKRAL 660
           E E R+   KREQ+  R   +REE+     Q+R+++Q +R++EE+RR   L  + E+R  
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498

Query: 661 AAERR 665
             ERR
Sbjct: 499 QQERR 503



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 4/61 (6%)

Query: 608  PEMEARQATRKREQKAARRQREEQQQRQQEQEEREREE----QRRFAALSDREKRALAAE 663
            PE   RQ   K+ ++    Q+EE+Q  ++E+E+R R+E     R+   L   E++ L  E
Sbjct: 978  PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037

Query: 664  R 664
            R
Sbjct: 1038 R 1038



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 17/58 (29%), Positives = 33/58 (56%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           ++   Q   +REQ+  R Q EE++++Q  +E++ R EQ+       R ++ L  E++L
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 23/67 (34%), Positives = 36/67 (53%), Gaps = 9/67 (13%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQ----QEQEER-----EREEQRRFAALSDREKRA 659
           E+E  +   +REQ+  R + EE++++Q    +EQEER      RE+Q R      RE+  
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665

Query: 660 LAAERRL 666
              E+RL
Sbjct: 666 ERLEQRL 672



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 31/112 (27%), Positives = 50/112 (44%), Gaps = 12/112 (10%)

Query: 354 REAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQV 413
           RE       Q H +  RE+R K  +EE R   + E+E     +E  KQ    + E+    
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE---- 482

Query: 414 ELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEE 465
                E     L L E E   +R +++R +++  R+QE    + L +Q +EE
Sbjct: 483 -----ERRERWLKLEEEE---RREQQERREQQLRREQEERREQRLKRQEEEE 526



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 20/61 (32%), Positives = 31/61 (50%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAA 668
           E   R    +R+Q+  R Q EE+++R  + EE ER EQ+       R ++    E+RL  
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521

Query: 669 Q 669
           Q
Sbjct: 522 Q 522



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 19/50 (38%), Positives = 31/50 (62%), Gaps = 2/50 (4%)

Query: 619 REQKAARRQREEQQQRQQE--QEEREREEQRRFAALSDREKRALAAERRL 666
           REQ+  + + EE+QQR+Q    EE E+E++RR     ++E + L  E +L
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 15/42 (35%), Positives = 29/42 (69%), Gaps = 2/42 (4%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQE--EREREEQRR 648
           E++  +  ++R Q+  R+ REE+Q +Q+E++    ERE++RR
Sbjct: 912 ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 17/49 (34%), Positives = 30/49 (61%)

Query: 610  MEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKR 658
            ++  Q  R++E+   RRQ  +++ R++EQ  +EREEQ+      DR+ R
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 17/53 (32%), Positives = 35/53 (66%), Gaps = 1/53 (1%)

Query: 619  REQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLG 671
            RE++  R++REEQQ  +QE++ + R E+++     ++E++ +  E++L  Q G
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQK-VRRQEQERKFMEDEQQLRRQEG 1609



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 17/51 (33%), Positives = 30/51 (58%)

Query: 619  REQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQ 669
            R Q+  R+ REE+Q RQ+ ++E+ R ++R    L + + R    E++L  Q
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQ 1767



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 17/62 (27%), Positives = 30/62 (48%)

Query: 597 YNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDRE 656
           Y K  +   L  E +  Q   +  Q+  R +R  Q+Q +Q +EE + +++       +RE
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949

Query: 657 KR 658
           KR
Sbjct: 950 KR 951



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 20/60 (33%), Positives = 34/60 (56%), Gaps = 2/60 (3%)

Query: 610  MEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQ 669
            ME  Q  R++E +   RQ  +++ R+ EQ  +EREEQ+      +R+++ L  E +L  Q
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR--QERDRKFLEEEPQLRRQ 1655



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 17/51 (33%), Positives = 36/51 (70%), Gaps = 2/51 (3%)

Query: 609  EMEARQATRK-REQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKR 658
            ++ ++++ RK RE++  R++REEQQ R Q+++ + R E+ +   L ++E+R
Sbjct: 1787 QLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL-QLEEQEQR 1836



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 7/74 (9%)

Query: 604 GPLTPEMEARQATRKREQKAARRQ-REEQQQRQQE------QEEREREEQRRFAALSDRE 656
           G  T E    +  R+RE    RR+ REE+QQ+++E      QEE E+E ++R   L   E
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE 257

Query: 657 KRALAAERRLAAQL 670
           ++    E +   +L
Sbjct: 258 EKLQEEEPQRQREL 271



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 17/58 (29%), Positives = 35/58 (60%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           E E R+   +REQ+  RR+++ ++++Q  +E++ R EQ+       R ++ L  E++L
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 19/58 (32%), Positives = 34/58 (58%), Gaps = 6/58 (10%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEERE----REEQRRFAALSDREKRALAAER 664
           E R   ++ E++  +R R EQQ R++++E RE    REE++R     +R ++ L  E+
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE--QERREQRLKREQ 571



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 19/62 (30%), Positives = 35/62 (56%), Gaps = 6/62 (9%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEERE----REEQRRFAALSDREKRALAAER 664
           E    Q  ++ E+K   ++R EQ+ +++++E R+    REE+RR   L   ++  L  E+
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL--EQ 600

Query: 665 RL 666
           RL
Sbjct: 601 RL 602



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 14/106 (13%)

Query: 363  QTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVELTV 422
            Q   + +REER+K   +E  +  R+E+E L Q EE   Q  G E E   + ELE      
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEE-LQQEEE---QLLGEERETRRRQELERQYRKE 1083

Query: 423  GTLDLCESEVL---PKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEE 465
              L   E ++L   P++RRR+  +++   ++E       LQQ +E+
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEE-------LQQEEEQ 1122



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 14/58 (24%), Positives = 34/58 (58%)

Query: 609  EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
            ++  ++  ++  Q   R+ REE+QQ  +++ +R+  E+ +     +RE++ L  E++L
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQL 1455



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 16/55 (29%), Positives = 33/55 (60%), Gaps = 1/55 (1%)

Query: 611  EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
            E  Q  ++ E++  RRQ  +++ R++EQ+ R +E +R+F    +++ R    ER+
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ-EEQQLRRQELERK 1724



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 20/59 (33%), Positives = 35/59 (59%), Gaps = 5/59 (8%)

Query: 611 EARQATRKREQKAARRQ---REEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL 666
           E R+   +REQ+  RR+   R EQ++ ++EQ+ R  ++ RR   L  R ++ L  E++L
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL--RREQQLRREQQL 401



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 21/86 (24%), Positives = 44/86 (51%), Gaps = 2/86 (2%)

Query: 581 RNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEE 640
           R+  +R  E      +  K Q+      E   R    + E++  +++R EQQ R++++E 
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514

Query: 641 REREEQRRFAALSDREKRALAAERRL 666
           RE+  +R+     +R ++ L +E++L
Sbjct: 515 REQRLKRQ--EEEERLQQRLRSEQQL 538



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 16/60 (26%), Positives = 34/60 (56%)

Query: 606 LTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
           L  E E R   R + ++  R ++EE+++++ ++EE E E +++     ++E+R     RR
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 17/67 (25%), Positives = 38/67 (56%), Gaps = 2/67 (2%)

Query: 606 LTPEMEARQATRKREQKAARRQREE--QQQRQQEQEEREREEQRRFAALSDREKRALAAE 663
           L  E + R+   +R ++  +R+ E+  +Q+R++++ +RE+EE+R      + E+R    +
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591

Query: 664 RRLAAQL 670
           R    +L
Sbjct: 592 REQEERL 598



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 32/136 (23%), Positives = 62/136 (45%), Gaps = 9/136 (6%)

Query: 334  QELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALG 393
            +E +R  H L      +E  R+  +L   +   +  REER+K   +E  +  R+E++   
Sbjct: 880  EERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-ELQREEREKRRRQEQERQYREEEQLQQ 938

Query: 394  QNE----ESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRD 449
            + E    E  ++    E E  ++ + +L +     L     E   KRRR++R KK +  +
Sbjct: 939  EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL----GEEPEKRRRQEREKKYREEE 994

Query: 450  QEAGAHRTLLQQTQEE 465
            +       LL++ +E+
Sbjct: 995  ELQQEEEQLLREEREK 1010



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 19/54 (35%), Positives = 33/54 (61%), Gaps = 8/54 (14%)

Query: 617  RKREQKAARRQRE-----EQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
            R+ EQ+  R++RE     E+QQ +QE+  + REE++    L +RE++ L  + R
Sbjct: 1433 REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ---LLQEREEQQLHRQER 1483



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 19/82 (23%), Positives = 44/82 (53%), Gaps = 1/82 (1%)

Query: 585  RRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQR-QQEQEERER 643
            R+F+E+    +   + +       ++  ++  ++R Q   R+ REE+Q R ++E+++  R
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574

Query: 644  EEQRRFAALSDREKRALAAERR 665
            +E+ R   L +++ R    ER+
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERK 1596



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 13/39 (33%), Positives = 26/39 (66%)

Query: 611  EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRF 649
            E  Q  ++RE++   RQ  +++ R +EQ+ R +E++R+F
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 17/56 (30%), Positives = 32/56 (57%), Gaps = 4/56 (7%)

Query: 614  QATRKREQKAARRQREEQQQRQQEQEEREREEQRRF----AALSDREKRALAAERR 665
            Q  R++EQ+    + E+Q +RQ+ Q++  +E  R+F      L +RE++ L  + R
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 16/62 (25%), Positives = 36/62 (58%), Gaps = 4/62 (6%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEER----EREEQRRFAALSDREKRALAAER 664
           E   R+   ++E++  + +  ++Q+  QE+EE+    ER+E RR     +++++ L  E+
Sbjct: 245 EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ 304

Query: 665 RL 666
           +L
Sbjct: 305 QL 306



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 22/59 (37%), Positives = 32/59 (54%), Gaps = 6/59 (10%)

Query: 613 RQATRKREQKAARRQ--REEQQQRQQEQEERE----REEQRRFAALSDREKRALAAERR 665
           R+   +REQ+  R Q  R EQQ R+++Q  RE    RE+Q R     +R ++    ERR
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 8/66 (12%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQ--------EEREREEQRRFAALSDREKRAL 660
           ++   Q   + EQK  + +RE++ +R+QE+        EE ER EQ R      R++   
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE 483

Query: 661 AAERRL 666
             ER L
Sbjct: 484 RRERWL 489



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 20/64 (31%), Positives = 37/64 (57%), Gaps = 5/64 (7%)

Query: 609  EMEARQATRKR---EQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
            E + R+  R+R   E++   RQ   ++ R++EQ  +EREEQ+      +R+++ L  E++
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR--QERDRKFLEEEQQ 1493

Query: 666  LAAQ 669
            L  Q
Sbjct: 1494 LRRQ 1497



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 21/68 (30%), Positives = 35/68 (51%), Gaps = 8/68 (11%)

Query: 606  LTPEMEARQATRK--REQKAARRQREEQQQRQQE------QEEREREEQRRFAALSDREK 657
            L  E + RQ   +  RE++   ++REEQQ  +QE      +EE++   Q R     ++E 
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508

Query: 658  RALAAERR 665
            R+   ER+
Sbjct: 1509 RSQEPERK 1516



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 13/32 (40%), Positives = 23/32 (71%)

Query: 613  RQATRKREQKAARRQREEQQQRQQEQEERERE 644
            ++  +KR Q+  R+ REE  +RQQ++E+R R+
Sbjct: 1866 QEEEQKRRQERERKLREEHIRRQQKEEQRHRQ 1897



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 2/59 (3%)

Query: 609 EMEARQATRKREQKAARRQ--REEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
           E E R+   +REQ+  R Q  R EQQ R+++Q  RE++ +R      +++ R     RR
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 14/56 (25%), Positives = 29/56 (51%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAER 664
           ++   Q  R+ +Q    +Q   +QQ ++EQ+ R  +E+ R     ++E+R    +R
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 14/54 (25%), Positives = 36/54 (66%), Gaps = 1/54 (1%)

Query: 606 LTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALS-DREKR 658
           L  E + R+  + R ++  RR+++ ++++++E+ E++ E++RR   L  ++E+R
Sbjct: 401 LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 15/53 (28%), Positives = 29/53 (54%)

Query: 613 RQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
           R+   +REQ+  R Q+  ++Q+ + ++E ER EQ+      ++  +    ERR
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 7/67 (10%)

Query: 606 LTPEMEARQATRKREQKAARRQREEQQQRQQEQEER-----EREEQRRFAALSDRE--KR 658
           L  E E R    +REQ+  R Q E + Q  + +EER     +RE++ R      RE  +R
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609

Query: 659 ALAAERR 665
               ERR
Sbjct: 610 LEQEERR 616



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 16/62 (25%), Positives = 33/62 (53%)

Query: 609  EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAA 668
            E++  +    RE++  RR +E ++Q ++E+E ++ EEQ        R ++ L  + R   
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084

Query: 669  QL 670
            +L
Sbjct: 1085 EL 1086



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 37/153 (24%), Positives = 56/153 (36%), Gaps = 23/153 (15%)

Query: 330 RPTFQELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICR--- 386
           RP  QE QR            ++  E  R    +  W+      ++  EEE R+      
Sbjct: 722 RPRKQEGQR----------RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771

Query: 387 --DEKEALGQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKK 444
             +EK   G+   S +     + E   + E    E           E   ++RRR+R ++
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAE----ERQQREQRFLPEEEEKEQRRRQRRER 827

Query: 445 EKS----RDQEAGAHRTLLQQTQEEEPSTQSSQ 473
           EK      ++E    R   QQ QEEE   Q  Q
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ 860



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 22/64 (34%), Positives = 34/64 (53%), Gaps = 8/64 (12%)

Query: 618 KREQKAARRQREEQQQRQ-----QEQEEREREEQRRFAA---LSDREKRALAAERRLAAQ 669
           + E++A R+Q+EE+Q+R      Q +E+ ER  QR  A       RE++  A ER+   Q
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808

Query: 670 LGAP 673
              P
Sbjct: 809 RFLP 812



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)

Query: 609  EMEARQATRKREQKAARRQREEQQQRQQEQEER---EREEQRRFAALSDREKRALAAERR 665
            E   RQ   ++ +K    Q+EE+Q  ++E+E+R   ERE Q R      +E+  L  E R
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 16/62 (25%), Positives = 34/62 (54%)

Query: 609  EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAA 668
            E++  +    RE++  RR++E ++Q ++E+E ++ EEQ        R ++ L  + R   
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174

Query: 669  QL 670
            +L
Sbjct: 1175 EL 1176



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 37/137 (27%), Positives = 57/137 (41%), Gaps = 21/137 (15%)

Query: 334  QELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALG 393
            +ELQR   +       E   RE  +L   Q   + +REER+K   +E  +  R +K+   
Sbjct: 911  EELQREEREKRRRQEQERQYREEEQLQ--QEEEQLLREEREKRRRQERERQYRKDKKLQQ 968

Query: 394  QNE----ESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRD 449
            + E    E P++    E E  ++ E EL +         E E L       R ++EK R 
Sbjct: 969  KEEQLLGEEPEKRRRQEREKKYREEEELQQ---------EEEQL------LREEREKRRR 1013

Query: 450  QEAGAHRTLLQQTQEEE 466
            QE         + Q+EE
Sbjct: 1014 QEWERQYRKKDELQQEE 1030



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 38/142 (26%), Positives = 65/142 (45%), Gaps = 11/142 (7%)

Query: 337  QRVLHKLTTLHVYEEDPREAVRL-HSPQTHWKTVREERK-KPTEEEIRKICRDEKEALGQ 394
            QR  H      +  E+ +EA R     Q   + +REER+ K   +E  +  R+E++ L +
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347

Query: 395  NEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKE------KSR 448
             EE P +    E +  F+ E EL     G   L E + L ++ R ++  KE      + R
Sbjct: 1348 REEQPLR--RQERDRKFREE-ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404

Query: 449  DQEAGAHRTLLQQTQEEEPSTQ 470
            +Q+    R    + +E++ S Q
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQ 1426



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 17/59 (28%), Positives = 33/59 (55%), Gaps = 3/59 (5%)

Query: 611  EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQ 669
            E  Q  ++RE++  R Q+ + + R +E++ +  E+++R     DR+ R   AE + A Q
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR---AEEQFATQ 1854



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 21/63 (33%), Positives = 33/63 (52%), Gaps = 5/63 (7%)

Query: 609 EMEARQATRKREQKAARRQ--REEQQQRQQEQEERE---REEQRRFAALSDREKRALAAE 663
           ++   Q   +REQ+  R Q  R EQQ R+++Q  RE   R EQ+       R ++ L  E
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422

Query: 664 RRL 666
           ++L
Sbjct: 423 QQL 425



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 8/118 (6%)

Query: 355  EAVRLHSPQTHWKTVREERKKPTEE--EIRKICRD----EKEALGQNEESPKQGSGSEGE 408
            E  +LH  Q   K ++EE++   +E  + R+  RD    E+E L Q  E  +Q S  E +
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE-QQLSRQERD 1578

Query: 409  DGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEE 466
              F++E + V          E E    RR+  + +  + RD++      LLQ+ +E++
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQ-QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 9/59 (15%)

Query: 609  EMEARQATRKR----EQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAE 663
            E + R+  R R    E++  RRQ  E++  Q+EQ+ R +E +R+F     RE+  L  E
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF-----REEEQLRQE 1734



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 16/53 (30%), Positives = 32/53 (60%), Gaps = 4/53 (7%)

Query: 617 RKREQKAARRQ----REEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
           ++ E+K  R++    R+E+++ Q+E+ +R+RE Q     L   E++ L  ER+
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ 291



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 8/109 (7%)

Query: 370 REERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCE 429
           R+   +  EE++RK+ R E     Q EE  +Q    E +   + E E  E      +  E
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326

Query: 430 SEVLPKRRRRKRNKKEKS--------RDQEAGAHRTLLQQTQEEEPSTQ 470
                + RR ++ ++E+         R+QE       L++ QEEE   Q
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 14/54 (25%), Positives = 33/54 (61%), Gaps = 3/54 (5%)

Query: 611 EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAER 664
           + R+  +  +++    QREE+++R+++++ER+  E+ +   L   E++ L  ER
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ---LQQEEEQLLREER 948



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 13/38 (34%), Positives = 24/38 (63%)

Query: 611  EARQATRKREQKAARRQREEQQQRQQEQEEREREEQRR 648
            E  +  R++E++   R+ EE QQ +++    ERE++RR
Sbjct: 976  EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 16/50 (32%), Positives = 29/50 (58%), Gaps = 1/50 (2%)

Query: 609  EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKR 658
            E   R+   KR ++   RQ  ++ + QQE+E+  REE+ +   L +RE++
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK-RRLQERERQ 1049



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 21/65 (32%), Positives = 38/65 (58%), Gaps = 8/65 (12%)

Query: 609  EMEARQATRK--REQKAARRQREEQQQRQQEQEER--EREEQRRFAALSDREKRALAAER 664
            E+  ++  RK   E++  RRQ  E++  ++EQ+ R  ERE+Q R     DR+++    E+
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR----QDRDRKFREEEQ 1421

Query: 665  RLAAQ 669
            +L+ Q
Sbjct: 1422 QLSRQ 1426



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 18/60 (30%), Positives = 32/60 (53%), Gaps = 7/60 (11%)

Query: 606  LTPEMEARQATRKR-------EQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKR 658
            L  E E +Q +R+        E++  RRQ +E++  + EQ+ R +E Q++     DR+ R
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622


>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
           isoform 1 [Homo sapiens]
          Length = 274

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 32/80 (40%), Positives = 42/80 (52%), Gaps = 18/80 (22%)

Query: 492 PELWNALL--AACRAGDVGVLKLQL----APSPADPRVLSLLSAPLGSGGFTLLHAAAAA 545
           PEL   L   AA  AGDV  ++  L    +P+  D            + G+TLLH +AA 
Sbjct: 10  PELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRD------------ANGWTLLHFSAAR 57

Query: 546 GRGSVVRLLLEAGADPTVQD 565
           G+   VR+ LE GADPTV+D
Sbjct: 58  GKERCVRVFLEHGADPTVKD 77



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 32/120 (26%), Positives = 55/120 (45%), Gaps = 13/120 (10%)

Query: 460 QQTQEEEPSTQSSQAVAA----PLGPLLDEAKAPGQPEL--WNALLAACRAGDVGVLKLQ 513
           ++  E +   Q   AVAA     +  +L++  +P   +   W  L  +   G    +++ 
Sbjct: 7   RRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVF 66

Query: 514 LAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYT 573
           L    ADP V  L+      GGFT LH AA  GR  + RL+LE+     + ++++   +T
Sbjct: 67  LEHG-ADPTVKDLI------GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWT 119



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 18/41 (43%), Positives = 22/41 (53%)

Query: 535 GFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVA 575
           G+T LH AA  GR S VRLLLE  A+      +   P  +A
Sbjct: 117 GWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 40/155 (25%), Positives = 64/155 (41%), Gaps = 19/155 (12%)

Query: 535 GFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDA 594
           G T LH AAA     V ++LLEAGAD T+ ++  + P   A       E    + K P  
Sbjct: 207 GDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR-YHNNPEVALLLTKAPQV 265

Query: 595 YDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQ----------QEQEERERE 644
             +++ +        +  ++   K E++A    R+E  Q +           EQ    +E
Sbjct: 266 LRFSRGR-------SLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKE 318

Query: 645 EQRRFAALSDREKRALAAERRLA-AQLGAPTSPIP 678
           E R     +  E RA    RR +  ++ A + P P
Sbjct: 319 EAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTP 353



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 17/31 (54%), Positives = 20/31 (64%)

Query: 535 GFTLLHAAAAAGRGSVVRLLLEAGADPTVQD 565
           G T LH AA  G   VV++LL+AG D  VQD
Sbjct: 42  GRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 32/105 (30%), Positives = 47/105 (44%), Gaps = 8/105 (7%)

Query: 495 WNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLL 554
           W  L  A   G + ++ L LA S A+          LG+  +T LH AA  G  +VV  L
Sbjct: 594 WTPLHLAAYKGHLEIIHL-LAESHAN-------MGALGAVNWTPLHLAARHGEEAVVSAL 645

Query: 555 LEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNK 599
           L+ GADP   +     P  +A  +ST       +E + + +  NK
Sbjct: 646 LQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 31/106 (29%), Positives = 44/106 (41%), Gaps = 10/106 (9%)

Query: 493 ELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVR 552
           E W  L  A +     V +L L    ADP +         + G T LH AA  G  S+V+
Sbjct: 460 EGWTPLHLAAQNNFENVARL-LVSRQADPNLHE-------AEGKTPLHVAAYFGHVSLVK 511

Query: 553 LLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKN--PDAYD 596
           LL   GA+   Q    R P  +A ++      +  ++    PDA D
Sbjct: 512 LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALD 557



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 37/109 (33%), Positives = 47/109 (43%), Gaps = 17/109 (15%)

Query: 481 PLLDEAKAPGQPELWNALLA----ACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSG-- 534
           PLL  A+   QP+L   LLA    A R  + G   L  A    D     LL   L  G  
Sbjct: 398 PLLIAAQDQ-QPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL---LDHGAC 453

Query: 535 -------GFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAA 576
                  G+T LH AA     +V RLL+   ADP + ++  + P  VAA
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAA 502



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 535 GFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFME 589
           G+T  H AA  G  +++++L+EAGA   VQD  +  P  +A  +S +     F+E
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL-RSRKQGIMSFLE 745


>gi|55956910 meningioma  1 [Homo sapiens]
          Length = 1320

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 20/59 (33%), Positives = 43/59 (72%), Gaps = 4/59 (6%)

Query: 619 REQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRL----AAQLGAP 673
           ++Q+  ++Q+++QQQ+QQ+Q+++++++QR+ AAL  ++  +   ++RL     AQLG P
Sbjct: 523 QQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHP 581


>gi|21361517 UBX domain protein 1 [Homo sapiens]
          Length = 312

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 32/116 (27%), Positives = 57/116 (49%), Gaps = 6/116 (5%)

Query: 554 LLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEAR 613
           L+E   DP V +    P   +   + T +E +  +E +  A    K     P   E E +
Sbjct: 39  LMEHEDDPDVDEPLETPLGHILGREPTSSE-QGGLEGSGSAAGEGK-----PALSEEERQ 92

Query: 614 QATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQ 669
           + T++  +  A++QRE +++ ++E  ERER+ +R+   LS   +R    E R AA+
Sbjct: 93  EQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAE 148



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 20/62 (32%), Positives = 35/62 (56%), Gaps = 4/62 (6%)

Query: 613 RQATRKREQKAARRQREEQQQRQQEQEERER---EEQRRFAALSDREK-RALAAERRLAA 668
           R+   + E++A  R+R+ ++Q Q+    R+R   +E RR A    REK   LAA +R+  
Sbjct: 107 REREEREEREALERERQRRRQGQELSAARQRLQEDEMRRAAEERRREKAEELAARQRVRE 166

Query: 669 QL 670
           ++
Sbjct: 167 KI 168


>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
          Length = 715

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 17/75 (22%), Positives = 49/75 (65%)

Query: 595 YDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSD 654
           Y   + Q+   L  + + +Q  ++++Q+  ++Q+++QQQ+QQ+Q+++++++Q+     + 
Sbjct: 139 YKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAK 198

Query: 655 REKRALAAERRLAAQ 669
            +++    +++LAAQ
Sbjct: 199 EQQQQQQQQQQLAAQ 213



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 14/65 (21%), Positives = 43/65 (66%)

Query: 606 LTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERR 665
           L  + + +Q  ++++Q+  ++Q+++QQQ+QQ+Q+++++++Q       +++++    ++ 
Sbjct: 151 LQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQL 210

Query: 666 LAAQL 670
            A QL
Sbjct: 211 AAQQL 215



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 14/61 (22%), Positives = 41/61 (67%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAA 668
           + + +Q  ++++Q+  ++Q+++QQQ+QQ+Q+++   +Q +      ++++ LAA++ +  
Sbjct: 159 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQ 218

Query: 669 Q 669
           Q
Sbjct: 219 Q 219



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 13/60 (21%), Positives = 41/60 (68%)

Query: 613 RQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGA 672
           +Q  ++++Q+  ++Q+++QQQ+QQ+Q+++++++Q++      ++ +    +++   QL A
Sbjct: 153 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAA 212



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 11/40 (27%), Positives = 28/40 (70%)

Query: 609 EMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRR 648
           + +  Q   K++Q+    Q  +QQQ+QQ+Q+++++++Q++
Sbjct: 131 QQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQ 170


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,700,469
Number of Sequences: 37866
Number of extensions: 1666243
Number of successful extensions: 28908
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 525
Number of HSP's successfully gapped in prelim test: 384
Number of HSP's that attempted gapping in prelim test: 14079
Number of HSP's gapped (non-prelim): 8935
length of query: 726
length of database: 18,247,518
effective HSP length: 110
effective length of query: 616
effective length of database: 14,082,258
effective search space: 8674670928
effective search space used: 8674670928
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press