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Search of human proteins with 4557501
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557501 cathepsin O preproprotein [Homo sapiens]
(321 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557501 cathepsin O preproprotein [Homo sapiens] 675 0.0
gi|6042196 cathepsin F [Homo sapiens] 158 7e-39
gi|23110957 cathepsin H isoform b precursor [Homo sapiens] 147 2e-35
gi|23110955 cathepsin H isoform a preproprotein [Homo sapiens] 147 2e-35
gi|23110962 cathepsin S preproprotein [Homo sapiens] 141 9e-34
gi|23110960 cathepsin L2 preproprotein [Homo sapiens] 141 9e-34
gi|22202619 cathepsin L1 preproprotein [Homo sapiens] 136 3e-32
gi|4503155 cathepsin L1 preproprotein [Homo sapiens] 136 3e-32
gi|4503151 cathepsin K preproprotein [Homo sapiens] 129 3e-30
gi|23110964 cathepsin W preproprotein [Homo sapiens] 128 8e-30
gi|189083844 cathepsin C isoform a preproprotein [Homo sapiens] 96 4e-20
gi|22538442 cathepsin Z preproprotein [Homo sapiens] 96 4e-20
gi|22538437 cathepsin B preproprotein [Homo sapiens] 89 4e-18
gi|22538435 cathepsin B preproprotein [Homo sapiens] 89 4e-18
gi|22538433 cathepsin B preproprotein [Homo sapiens] 89 4e-18
gi|22538431 cathepsin B preproprotein [Homo sapiens] 89 4e-18
gi|4503139 cathepsin B preproprotein [Homo sapiens] 89 4e-18
gi|224586907 tubulointerstitial nephritis antigen [Homo sapiens] 73 3e-13
gi|11545918 tubulointerstitial nephritis antigen-like 1 [Homo sa... 64 2e-10
gi|111074532 OGT(O-Glc-NAc transferase)-interacting protein 106 ... 30 2.2
gi|45359873 OGT(O-Glc-NAc transferase)-interacting protein 106 K... 30 2.2
gi|115305569 adenosine A1 receptor [Homo sapiens] 30 2.9
gi|4501947 adenosine A1 receptor [Homo sapiens] 30 2.9
gi|4505579 furin preproprotein [Homo sapiens] 29 4.9
gi|21237808 SWI/SNF-related matrix-associated actin-dependent re... 29 4.9
gi|21237805 SWI/SNF-related matrix-associated actin-dependent re... 29 4.9
gi|194363725 SWI/SNF-related matrix-associated actin-dependent r... 29 4.9
gi|157785649 leucine-rich repeats and IQ motif containing 3 [Hom... 29 6.4
gi|21389491 family with sequence similarity 82, member A1 [Homo ... 28 8.4
gi|14861858 hypothetical protein LOC85411 [Homo sapiens] 28 8.4
>gi|4557501 cathepsin O preproprotein [Homo sapiens]
Length = 321
Score = 675 bits (1742), Expect = 0.0
Identities = 321/321 (100%), Positives = 321/321 (100%)
Query: 1 MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPS 60
MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPS
Sbjct: 1 MDVRALPWLPWLLWLLCRGGGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLNSLFPS 60
Query: 61 ENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVV 120
ENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVV
Sbjct: 61 ENSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVV 120
Query: 121 TQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALN 180
TQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALN
Sbjct: 121 TQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALN 180
Query: 181 WLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGP 240
WLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGP
Sbjct: 181 WLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGP 240
Query: 241 LVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGY 300
LVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGY
Sbjct: 241 LVVIVDAVSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGY 300
Query: 301 AHVKMGSNVCGIADSVSSIFV 321
AHVKMGSNVCGIADSVSSIFV
Sbjct: 301 AHVKMGSNVCGIADSVSSIFV 321
>gi|6042196 cathepsin F [Homo sapiens]
Length = 484
Score = 158 bits (399), Expect = 7e-39
Identities = 99/299 (33%), Positives = 153/299 (51%), Gaps = 11/299 (3%)
Query: 29 FTPTWPRSRE-REAAAFRESL--NRHRYLNSLFPSENSTAFYGINQFSYLFPEEFKAIYL 85
F T+ R+ E +E A +R S+ N + + TA YG+ +FS L EEF+ IYL
Sbjct: 190 FVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYL 249
Query: 86 RSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAY 145
+ K P + S+ +++ P +DWR K VT+V++Q MCG CWAFSV G VE +
Sbjct: 250 NTLLRKEPGNKMKQAKSVGDLAPP-EWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQW 308
Query: 146 AIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCH 205
+ L LS Q+++DC + C GG NA + + + L + +Y ++ C+
Sbjct: 309 FLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLG-GLETEDDYSYQGHMQSCN 367
Query: 206 YFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVIVDAVSWQDYLGGI---IQHHC 262
FS + I + + S E ++A L GP+ V ++A Q Y GI ++ C
Sbjct: 368 -FSAEKAKVYIN--DSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPLRPLC 424
Query: 263 SSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCGIADSVSSIFV 321
S +HAVL+ G+ P+W ++NSWG+ WG GY ++ GS CG+ SS V
Sbjct: 425 SPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAVV 483
>gi|23110957 cathepsin H isoform b precursor [Homo sapiens]
Length = 323
Score = 147 bits (370), Expect = 2e-35
Identities = 90/267 (33%), Positives = 134/267 (50%), Gaps = 20/267 (7%)
Query: 62 NSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDK-QVV 120
N T +NQFS + E K YL S+P + P DWR K V
Sbjct: 60 NHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTG--PYPPSVDWRKKGNFV 117
Query: 121 TQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCS--YNNYGCNGGSTLNA 178
+ V+NQ CG CW FS GA+ESA AI + L+ QQ++DC+ +NN+GC GG A
Sbjct: 118 SPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQA 177
Query: 179 LNWL--NKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGF--SIKGYSAYDFSDQEDEMAKA 234
++ NK ++ + YP++ ++G C + G GF + + YD E+ M +A
Sbjct: 178 FEYILYNK---GIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYD----EEAMVEA 230
Query: 235 LLTFGPLVVIVDAVS-WQDYLGGIIQH---HCSSGEANHAVLITGFDKTGSTPYWIVRNS 290
+ + P+ + + Y GI H + + NHAVL G+ + PYWIV+NS
Sbjct: 231 VALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNS 290
Query: 291 WGSSWGVDGYAHVKMGSNVCGIADSVS 317
WG WG++GY ++ G N+CG+A S
Sbjct: 291 WGPQWGMNGYFLIERGKNMCGLAACAS 317
>gi|23110955 cathepsin H isoform a preproprotein [Homo sapiens]
Length = 335
Score = 147 bits (370), Expect = 2e-35
Identities = 90/267 (33%), Positives = 134/267 (50%), Gaps = 20/267 (7%)
Query: 62 NSTAFYGINQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDK-QVV 120
N T +NQFS + E K YL S+P + P DWR K V
Sbjct: 72 NHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTG--PYPPSVDWRKKGNFV 129
Query: 121 TQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCS--YNNYGCNGGSTLNA 178
+ V+NQ CG CW FS GA+ESA AI + L+ QQ++DC+ +NN+GC GG A
Sbjct: 130 SPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQA 189
Query: 179 LNWL--NKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGF--SIKGYSAYDFSDQEDEMAKA 234
++ NK ++ + YP++ ++G C + G GF + + YD E+ M +A
Sbjct: 190 FEYILYNK---GIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYD----EEAMVEA 242
Query: 235 LLTFGPLVVIVDAVS-WQDYLGGIIQH---HCSSGEANHAVLITGFDKTGSTPYWIVRNS 290
+ + P+ + + Y GI H + + NHAVL G+ + PYWIV+NS
Sbjct: 243 VALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNS 302
Query: 291 WGSSWGVDGYAHVKMGSNVCGIADSVS 317
WG WG++GY ++ G N+CG+A S
Sbjct: 303 WGPQWGMNGYFLIERGKNMCGLAACAS 329
>gi|23110962 cathepsin S preproprotein [Homo sapiens]
Length = 331
Score = 141 bits (355), Expect = 9e-34
Identities = 90/255 (35%), Positives = 133/255 (52%), Gaps = 16/255 (6%)
Query: 68 GINQFSYLFPEEFKAIYLRSK-PSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQ 126
G+N + EE ++ + PS++ R + S PN LP DWR+K VT+V+ Q
Sbjct: 76 GMNHLGDMTSEEVMSLMSSLRVPSQWQRNIT--YKSNPNRILPDSVDWREKGCVTEVKYQ 133
Query: 127 QMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCS---YNNYGCNGGSTLNALNWL- 182
CG CWAFS VGA+E+ +K L LS Q ++DCS Y N GCNGG A ++
Sbjct: 134 GSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYII 193
Query: 183 -NKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPL 241
NK + D+ YP+KA + C Y S + + Y+ + +ED + +A+ GP+
Sbjct: 194 DNK---GIDSDASYPYKAMDQKCQYDS-KYRAATCSKYTELPYG-REDVLKEAVANKGPV 248
Query: 242 VVIVDA--VSWQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDG 299
V VDA S+ Y G+ + NH VL+ G+ YW+V+NSWG ++G +G
Sbjct: 249 SVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEG 308
Query: 300 YAHV-KMGSNVCGIA 313
Y + + N CGIA
Sbjct: 309 YIRMARNKGNHCGIA 323
>gi|23110960 cathepsin L2 preproprotein [Homo sapiens]
Length = 334
Score = 141 bits (355), Expect = 9e-34
Identities = 93/263 (35%), Positives = 134/263 (50%), Gaps = 23/263 (8%)
Query: 69 INQFSYLFPEEFKAIYLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRNQQM 128
+N F + EEF+ + + KF + +V + LP DWR K VT V+NQ+
Sbjct: 77 MNAFGDMTNEEFRQMMGCFRNQKFRK--GKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQ 134
Query: 129 CGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCS--YNNYGCNGGSTLNALNWLNKMQ 186
CG CWAFS GA+E K L LS Q ++DCS N GCNGG A ++ K
Sbjct: 135 CGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYV-KEN 193
Query: 187 VKLVKDSEYPFKAQNGLCHY----FSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLV 242
L + YP+ A + +C Y + +GF++ +E + KA+ T GP+
Sbjct: 194 GGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVA------PGKEKALMKAVATVGPIS 247
Query: 243 VIVDA--VSWQDYLGGI-IQHHCSSGEANHAVLITGFDKTG----STPYWIVRNSWGSSW 295
V +DA S+Q Y GI + CSS +H VL+ G+ G ++ YW+V+NSWG W
Sbjct: 248 VAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEW 307
Query: 296 GVDGYAHV-KMGSNVCGIADSVS 317
G +GY + K +N CGIA + S
Sbjct: 308 GSNGYVKIAKDKNNHCGIATAAS 330
>gi|22202619 cathepsin L1 preproprotein [Homo sapiens]
Length = 333
Score = 136 bits (342), Expect = 3e-32
Identities = 90/263 (34%), Positives = 130/263 (49%), Gaps = 24/263 (9%)
Query: 69 INQFSYLFPEEFKAI---YLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRN 125
+N F + EEF+ + + KP K + + P DWR+K VT V+N
Sbjct: 77 MNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPR-----SVDWREKGYVTPVKN 131
Query: 126 QQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCS--YNNYGCNGGSTLNALNWLN 183
Q CG CWAFS GA+E K L LS Q ++DCS N GCNGG A ++
Sbjct: 132 QGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQ 191
Query: 184 KMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAY-DFSDQEDEMAKALLTFGPLV 242
L + YP++A C Y + +S+ + + D QE + KA+ T GP+
Sbjct: 192 D-NGGLDSEESYPYEATEESCKY----NPKYSVANDTGFVDIPKQEKALMKAVATVGPIS 246
Query: 243 VIVDA--VSWQDYLGGI-IQHHCSSGEANHAVLITGF----DKTGSTPYWIVRNSWGSSW 295
V +DA S+ Y GI + CSS + +H VL+ G+ ++ + YW+V+NSWG W
Sbjct: 247 VAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEW 306
Query: 296 GVDGYAHV-KMGSNVCGIADSVS 317
G+ GY + K N CGIA + S
Sbjct: 307 GMGGYVKMAKDRRNHCGIASAAS 329
>gi|4503155 cathepsin L1 preproprotein [Homo sapiens]
Length = 333
Score = 136 bits (342), Expect = 3e-32
Identities = 90/263 (34%), Positives = 130/263 (49%), Gaps = 24/263 (9%)
Query: 69 INQFSYLFPEEFKAI---YLRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQVRN 125
+N F + EEF+ + + KP K + + P DWR+K VT V+N
Sbjct: 77 MNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPR-----SVDWREKGYVTPVKN 131
Query: 126 QQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCS--YNNYGCNGGSTLNALNWLN 183
Q CG CWAFS GA+E K L LS Q ++DCS N GCNGG A ++
Sbjct: 132 QGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQ 191
Query: 184 KMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAY-DFSDQEDEMAKALLTFGPLV 242
L + YP++A C Y + +S+ + + D QE + KA+ T GP+
Sbjct: 192 D-NGGLDSEESYPYEATEESCKY----NPKYSVANDTGFVDIPKQEKALMKAVATVGPIS 246
Query: 243 VIVDA--VSWQDYLGGI-IQHHCSSGEANHAVLITGF----DKTGSTPYWIVRNSWGSSW 295
V +DA S+ Y GI + CSS + +H VL+ G+ ++ + YW+V+NSWG W
Sbjct: 247 VAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEW 306
Query: 296 GVDGYAHV-KMGSNVCGIADSVS 317
G+ GY + K N CGIA + S
Sbjct: 307 GMGGYVKMAKDRRNHCGIASAAS 329
>gi|4503151 cathepsin K preproprotein [Homo sapiens]
Length = 329
Score = 129 bits (325), Expect = 3e-30
Identities = 77/213 (36%), Positives = 108/213 (50%), Gaps = 7/213 (3%)
Query: 109 PLRFDWRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNY 168
P D+R K VT V+NQ CG CWAFS VGA+E K L +LS Q ++DC N
Sbjct: 116 PDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSEND 175
Query: 169 GCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQE 228
GC GG NA ++ K + + + YP+ Q C Y + + +GY E
Sbjct: 176 GCGGGYMTNAFQYVQKNR-GIDSEDAYPYVGQEESCMY-NPTGKAAKCRGYREIP-EGNE 232
Query: 229 DEMAKALLTFGPLVVIVDA--VSWQDYLGGI-IQHHCSSGEANHAVLITGFDKTGSTPYW 285
+ +A+ GP+ V +DA S+Q Y G+ C+S NHAVL G+ +W
Sbjct: 233 KALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHW 292
Query: 286 IVRNSWGSSWGVDGY-AHVKMGSNVCGIADSVS 317
I++NSWG +WG GY + +N CGIA+ S
Sbjct: 293 IIKNSWGENWGNKGYILMARNKNNACGIANLAS 325
>gi|23110964 cathepsin W preproprotein [Homo sapiens]
Length = 376
Score = 128 bits (321), Expect = 8e-30
Identities = 84/278 (30%), Positives = 126/278 (45%), Gaps = 35/278 (12%)
Query: 64 TAFYGINQFSYLFPEEFKAIY-LRSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQ-VVT 121
TA +G+ FS L EEF +Y R P E+ P S+P DWR ++
Sbjct: 83 TAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGREIRSEEPEESVPFSCDWRKVAGAIS 142
Query: 122 QVRNQQMCGGCWAFSVVGAVESAYAIKGKPLEDLSVQQVIDCSYNNYGCNGGSTLNA-LN 180
+++Q+ C CWA + G +E+ + I D+SVQ+++DC GC+GG +A +
Sbjct: 143 PIKDQKNCNCCWAMAAAGNIETLWRISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFIT 202
Query: 181 WLNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDF---SDQEDEMAKALLT 237
LN + KD + K + CH + DF + E +A+ L T
Sbjct: 203 VLNNSGLASEKDYPFQGKVRAHRCHPKKYQKVAW------IQDFIMLQNNEHRIAQYLAT 256
Query: 238 FGPLVVIVDAVSWQDYLGGIIQHH---CSSGEANHAVLITGFDKTGS------------- 281
+GP+ V ++ Q Y G+I+ C +H+VL+ GF S
Sbjct: 257 YGPITVTINMKPLQLYRKGVIKATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSSQS 316
Query: 282 -------TPYWIVRNSWGSSWGVDGYAHVKMGSNVCGI 312
TPYWI++NSWG+ WG GY + GSN CGI
Sbjct: 317 QPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCGI 354
>gi|189083844 cathepsin C isoform a preproprotein [Homo sapiens]
Length = 463
Score = 95.9 bits (237), Expect = 4e-20
Identities = 72/244 (29%), Positives = 112/244 (45%), Gaps = 24/244 (9%)
Query: 86 RSKPSKFPRYSAEVHMSIPNVSLPLRFDWRDKQ---VVTQVRNQQMCGGCWAFSVVGAVE 142
R KP+ +AE+ I + LP +DWR+ V+ VRNQ CG C++F+ +G +E
Sbjct: 214 RPKPAPL---TAEIQQKI--LHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLE 268
Query: 143 SAYAI--KGKPLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQ 200
+ I LS Q+V+ CS GC GG + LV+++ +P+
Sbjct: 269 ARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPY-LIAGKYAQDFGLVEEACFPYTGT 327
Query: 201 NGLCHYFSGSHSGFSIKGYSAYDFSDQEDE--MAKALLTFGPLVVIVDAVS-WQDYLGGI 257
+ C +S + + F +E M L+ GP+ V + + Y GI
Sbjct: 328 DSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGI 387
Query: 258 IQHHCSSGE-------ANHAVLITGF--DKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSN 308
HH + NHAVL+ G+ D YWIV+NSWG+ WG +GY ++ G++
Sbjct: 388 Y-HHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTD 446
Query: 309 VCGI 312
C I
Sbjct: 447 ECAI 450
>gi|22538442 cathepsin Z preproprotein [Homo sapiens]
Length = 303
Score = 95.9 bits (237), Expect = 4e-20
Identities = 73/236 (30%), Positives = 104/236 (44%), Gaps = 30/236 (12%)
Query: 90 SKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQV---RNQ---QMCGGCWAFSVVGAVES 143
S +PR H + LP +DWR+ V RNQ Q CG CWA + A+
Sbjct: 48 STYPR----PHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMAD 103
Query: 144 AYAIKGK---PLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVK-------LVKDS 193
IK K P LSVQ VIDC N C GG+ L+ ++ ++ + KD
Sbjct: 104 RINIKRKGAWPSTLLSVQNVIDCG-NAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQ 162
Query: 194 EYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQ-----EDEMAKALLTFGPLVVIVDAV 248
E Q G C+ F H+ I+ Y+ + D ++M + GP+ + A
Sbjct: 163 ECDKFNQCGTCNEFKECHA---IRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMAT 219
Query: 249 S-WQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHV 303
+Y GGI + + NH V + G+ + T YWIVRNSWG WG G+ +
Sbjct: 220 ERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRI 275
>gi|22538437 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 89.4 bits (220), Expect = 4e-18
Identities = 67/253 (26%), Positives = 101/253 (39%), Gaps = 37/253 (14%)
Query: 101 MSIPNVSLPLRFD----WRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAI--KGKPLED 154
M ++ LP FD W + ++R+Q CG CWAF V A+ I +
Sbjct: 73 MFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVE 132
Query: 155 LSVQQVIDC--SYNNYGCNGGSTLNALN-WLNKMQVK--------------------LVK 191
+S + ++ C S GCNGG A N W K V V
Sbjct: 133 VSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVN 192
Query: 192 DSEYPFKAQNG------LCHY-FSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVI 244
S P + +C +S ++ GY++Y S+ E ++ + GP+
Sbjct: 193 GSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGA 252
Query: 245 VDAVS-WQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHV 303
S + Y G+ QH HA+ I G+ TPYW+V NSW + WG +G+ +
Sbjct: 253 FSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKI 312
Query: 304 KMGSNVCGIADSV 316
G + CGI V
Sbjct: 313 LRGQDHCGIESEV 325
>gi|22538435 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 89.4 bits (220), Expect = 4e-18
Identities = 67/253 (26%), Positives = 101/253 (39%), Gaps = 37/253 (14%)
Query: 101 MSIPNVSLPLRFD----WRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAI--KGKPLED 154
M ++ LP FD W + ++R+Q CG CWAF V A+ I +
Sbjct: 73 MFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVE 132
Query: 155 LSVQQVIDC--SYNNYGCNGGSTLNALN-WLNKMQVK--------------------LVK 191
+S + ++ C S GCNGG A N W K V V
Sbjct: 133 VSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVN 192
Query: 192 DSEYPFKAQNG------LCHY-FSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVI 244
S P + +C +S ++ GY++Y S+ E ++ + GP+
Sbjct: 193 GSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGA 252
Query: 245 VDAVS-WQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHV 303
S + Y G+ QH HA+ I G+ TPYW+V NSW + WG +G+ +
Sbjct: 253 FSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKI 312
Query: 304 KMGSNVCGIADSV 316
G + CGI V
Sbjct: 313 LRGQDHCGIESEV 325
>gi|22538433 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 89.4 bits (220), Expect = 4e-18
Identities = 67/253 (26%), Positives = 101/253 (39%), Gaps = 37/253 (14%)
Query: 101 MSIPNVSLPLRFD----WRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAI--KGKPLED 154
M ++ LP FD W + ++R+Q CG CWAF V A+ I +
Sbjct: 73 MFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVE 132
Query: 155 LSVQQVIDC--SYNNYGCNGGSTLNALN-WLNKMQVK--------------------LVK 191
+S + ++ C S GCNGG A N W K V V
Sbjct: 133 VSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVN 192
Query: 192 DSEYPFKAQNG------LCHY-FSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVI 244
S P + +C +S ++ GY++Y S+ E ++ + GP+
Sbjct: 193 GSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGA 252
Query: 245 VDAVS-WQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHV 303
S + Y G+ QH HA+ I G+ TPYW+V NSW + WG +G+ +
Sbjct: 253 FSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKI 312
Query: 304 KMGSNVCGIADSV 316
G + CGI V
Sbjct: 313 LRGQDHCGIESEV 325
>gi|22538431 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 89.4 bits (220), Expect = 4e-18
Identities = 67/253 (26%), Positives = 101/253 (39%), Gaps = 37/253 (14%)
Query: 101 MSIPNVSLPLRFD----WRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAI--KGKPLED 154
M ++ LP FD W + ++R+Q CG CWAF V A+ I +
Sbjct: 73 MFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVE 132
Query: 155 LSVQQVIDC--SYNNYGCNGGSTLNALN-WLNKMQVK--------------------LVK 191
+S + ++ C S GCNGG A N W K V V
Sbjct: 133 VSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVN 192
Query: 192 DSEYPFKAQNG------LCHY-FSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVI 244
S P + +C +S ++ GY++Y S+ E ++ + GP+
Sbjct: 193 GSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGA 252
Query: 245 VDAVS-WQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHV 303
S + Y G+ QH HA+ I G+ TPYW+V NSW + WG +G+ +
Sbjct: 253 FSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKI 312
Query: 304 KMGSNVCGIADSV 316
G + CGI V
Sbjct: 313 LRGQDHCGIESEV 325
>gi|4503139 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 89.4 bits (220), Expect = 4e-18
Identities = 67/253 (26%), Positives = 101/253 (39%), Gaps = 37/253 (14%)
Query: 101 MSIPNVSLPLRFD----WRDKQVVTQVRNQQMCGGCWAFSVVGAVESAYAI--KGKPLED 154
M ++ LP FD W + ++R+Q CG CWAF V A+ I +
Sbjct: 73 MFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVE 132
Query: 155 LSVQQVIDC--SYNNYGCNGGSTLNALN-WLNKMQVK--------------------LVK 191
+S + ++ C S GCNGG A N W K V V
Sbjct: 133 VSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVN 192
Query: 192 DSEYPFKAQNG------LCHY-FSGSHSGFSIKGYSAYDFSDQEDEMAKALLTFGPLVVI 244
S P + +C +S ++ GY++Y S+ E ++ + GP+
Sbjct: 193 GSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGA 252
Query: 245 VDAVS-WQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHV 303
S + Y G+ QH HA+ I G+ TPYW+V NSW + WG +G+ +
Sbjct: 253 FSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKI 312
Query: 304 KMGSNVCGIADSV 316
G + CGI V
Sbjct: 313 LRGQDHCGIESEV 325
>gi|224586907 tubulointerstitial nephritis antigen [Homo sapiens]
Length = 476
Score = 73.2 bits (178), Expect = 3e-13
Identities = 67/222 (30%), Positives = 92/222 (41%), Gaps = 40/222 (18%)
Query: 125 NQQMCGGCWAFSVVGAVESAYAI--KGKPLEDLSVQQVIDC-SYNNYGCNGGSTLNALNW 181
+Q+ C WAFS AI KG+ +LS Q +I C + N +GCN GS A +
Sbjct: 236 DQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWY 295
Query: 182 LNKMQVKLVKDSEYP-FKAQNGL---CHYFSGSH-----------------SGFSIKGYS 220
L K LV + YP FK QN C S S S +
Sbjct: 296 LRKRG--LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSP 353
Query: 221 AYDFSDQEDEMAKALLTFGPLVVIVDA-VSWQDYLGGIIQHHCSSGEAN--------HAV 271
Y S E E+ K ++ GP+ I+ + Y GI +H S+ + + HAV
Sbjct: 354 PYRVSSNETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAV 413
Query: 272 LITGFDKTGSTP-----YWIVRNSWGSSWGVDGYAHVKMGSN 308
+TG+ +WI NSWG SWG +GY + G N
Sbjct: 414 KLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVN 455
>gi|11545918 tubulointerstitial nephritis antigen-like 1 [Homo
sapiens]
Length = 467
Score = 63.5 bits (153), Expect = 2e-10
Identities = 66/260 (25%), Positives = 99/260 (38%), Gaps = 45/260 (17%)
Query: 104 PNVSLPLRFDWRDK--QVVTQVRNQQMCGGCWAFSVVGAVESAYAIK--GKPLEDLSVQQ 159
P LP F+ +K ++ + +Q C G WAFS +I G LS Q
Sbjct: 199 PGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQN 258
Query: 160 VIDC-SYNNYGCNGGSTLNALNWLNKMQVKLVKDSEYPFKAQN----------------- 201
++ C ++ GC GG A +L + V V D YPF +
Sbjct: 259 LLSCDTHQQQGCRGGRLDGAWWFLRRRGV--VSDHCYPFSGRERDEAGPAPPCMMHSRAM 316
Query: 202 GLCHYFSGSHSGFSIKGYS-------AYDFSDQEDEMAKALLTFGPLVVIVDA-VSWQDY 253
G + +H S + Y + E+ K L+ GP+ +++ + Y
Sbjct: 317 GRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLY 376
Query: 254 LGGIIQHHCSS--------GEANHAVLITGFDKT----GST-PYWIVRNSWGSSWGVDGY 300
GGI H S H+V ITG+ + G T YW NSWG +WG G+
Sbjct: 377 KGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGH 436
Query: 301 AHVKMGSNVCGIADSVSSIF 320
+ G N C I V ++
Sbjct: 437 FRIVRGVNECDIESFVLGVW 456
>gi|111074532 OGT(O-Glc-NAc transferase)-interacting protein 106 KDa
isoform 1 [Homo sapiens]
Length = 953
Score = 30.4 bits (67), Expect = 2.2
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 20 GGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLN 55
G D S+ P TP P S + E A R SL R YL+
Sbjct: 476 GNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLS 511
>gi|45359873 OGT(O-Glc-NAc transferase)-interacting protein 106 KDa
isoform 2 [Homo sapiens]
Length = 686
Score = 30.4 bits (67), Expect = 2.2
Identities = 16/36 (44%), Positives = 19/36 (52%)
Query: 20 GGDADSRAPFTPTWPRSREREAAAFRESLNRHRYLN 55
G D S+ P TP P S + E A R SL R YL+
Sbjct: 418 GNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLS 453
>gi|115305569 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 30.0 bits (66), Expect = 2.9
Identities = 25/78 (32%), Positives = 32/78 (41%), Gaps = 19/78 (24%)
Query: 106 VSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVV------------GAVESAYAIK---GK 150
V +PLR+ K VVT R GCW S V AVE A+A G+
Sbjct: 109 VKIPLRY----KMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGE 164
Query: 151 PLEDLSVQQVIDCSYNNY 168
P+ ++VI Y Y
Sbjct: 165 PVIKCEFEKVISMEYMVY 182
>gi|4501947 adenosine A1 receptor [Homo sapiens]
Length = 326
Score = 30.0 bits (66), Expect = 2.9
Identities = 25/78 (32%), Positives = 32/78 (41%), Gaps = 19/78 (24%)
Query: 106 VSLPLRFDWRDKQVVTQVRNQQMCGGCWAFSVV------------GAVESAYAIK---GK 150
V +PLR+ K VVT R GCW S V AVE A+A G+
Sbjct: 109 VKIPLRY----KMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGE 164
Query: 151 PLEDLSVQQVIDCSYNNY 168
P+ ++VI Y Y
Sbjct: 165 PVIKCEFEKVISMEYMVY 182
>gi|4505579 furin preproprotein [Homo sapiens]
Length = 794
Score = 29.3 bits (64), Expect = 4.9
Identities = 16/52 (30%), Positives = 21/52 (40%), Gaps = 6/52 (11%)
Query: 10 PWLLWLLCRGG------GDADSRAPFTPTWPRSREREAAAFRESLNRHRYLN 55
PWLLW++ G DA + FT TW A +H +LN
Sbjct: 5 PWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLN 56
>gi|21237808 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin c2 isoform b [Homo sapiens]
Length = 1130
Score = 29.3 bits (64), Expect = 4.9
Identities = 15/45 (33%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 182 LNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSD 226
L K+ +K D FKA LCH + ++ S +G+ YDF +
Sbjct: 73 LTKLPIKCFLD----FKAGGSLCHILAAAYKFKSDQGWRRYDFQN 113
>gi|21237805 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin c2 isoform a [Homo sapiens]
Length = 1214
Score = 29.3 bits (64), Expect = 4.9
Identities = 15/45 (33%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 182 LNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSD 226
L K+ +K D FKA LCH + ++ S +G+ YDF +
Sbjct: 73 LTKLPIKCFLD----FKAGGSLCHILAAAYKFKSDQGWRRYDFQN 113
>gi|194363725 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin c2 isoform c [Homo sapiens]
Length = 1152
Score = 29.3 bits (64), Expect = 4.9
Identities = 15/45 (33%), Positives = 23/45 (51%), Gaps = 4/45 (8%)
Query: 182 LNKMQVKLVKDSEYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSD 226
L K+ +K D FKA LCH + ++ S +G+ YDF +
Sbjct: 73 LTKLPIKCFLD----FKAGGSLCHILAAAYKFKSDQGWRRYDFQN 113
>gi|157785649 leucine-rich repeats and IQ motif containing 3 [Homo
sapiens]
Length = 624
Score = 28.9 bits (63), Expect = 6.4
Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 7/63 (11%)
Query: 36 SREREAAAFRESLNRHRYLNSLFPSENSTAFYGI------NQFSYL-FPEEFKAIYLRSK 88
+RER A E LN+ +Y EN N+F+YL E KA++L+ K
Sbjct: 449 ARERVRVAVNEHLNQKKYATQKLIEENKETIQNSLRQVWQNRFNYLEKARERKALFLKEK 508
Query: 89 PSK 91
K
Sbjct: 509 SQK 511
>gi|21389491 family with sequence similarity 82, member A1 [Homo
sapiens]
Length = 573
Score = 28.5 bits (62), Expect = 8.4
Identities = 13/40 (32%), Positives = 19/40 (47%)
Query: 272 LITGFDKTGSTPYWIVRNSWGSSWGVDGYAHVKMGSNVCG 311
L GF K ++PYW + S G+ +K S+ CG
Sbjct: 79 LFVGFQKRNASPYWQQSRANFDSEEDTGFTDIKSSSDHCG 118
>gi|14861858 hypothetical protein LOC85411 [Homo sapiens]
Length = 136
Score = 28.5 bits (62), Expect = 8.4
Identities = 9/18 (50%), Positives = 11/18 (61%)
Query: 285 WIVRNSWGSSWGVDGYAH 302
+I R WGS W + GY H
Sbjct: 31 FIARRCWGSQWDITGYIH 48
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,446,862
Number of Sequences: 37866
Number of extensions: 529345
Number of successful extensions: 1129
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1062
Number of HSP's gapped (non-prelim): 36
length of query: 321
length of database: 18,247,518
effective HSP length: 102
effective length of query: 219
effective length of database: 14,385,186
effective search space: 3150355734
effective search space used: 3150355734
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.