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Search of human proteins with 45439367
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens]
(439 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens] 898 0.0
gi|122939172 connexin 45 [Homo sapiens] 358 7e-99
gi|69122473 connexin 45 [Homo sapiens] 358 7e-99
gi|55953076 connexin 50 [Homo sapiens] 224 9e-59
gi|10190698 gap junction protein, delta 2, 36kDa [Homo sapiens] 222 5e-58
gi|14211941 gap junction protein, alpha 10 [Homo sapiens] 218 9e-57
gi|62865885 connexin 37 [Homo sapiens] 217 1e-56
gi|32483412 connexin 40 [Homo sapiens] 201 1e-51
gi|6631083 connexin 40 [Homo sapiens] 201 1e-51
gi|4504001 connexin 43 [Homo sapiens] 201 1e-51
gi|145699105 connexin40.1 [Homo sapiens] 154 2e-37
gi|22779877 connexin 46 [Homo sapiens] 142 5e-34
gi|31542845 gap junction protein, alpha 9, 59kDa [Homo sapiens] 130 2e-30
gi|42558283 gap junction protein beta 2 [Homo sapiens] 116 4e-26
gi|23397464 gap junction protein, beta 4 [Homo sapiens] 116 5e-26
gi|148233402 gap junction protein, beta 1, 32kDa [Homo sapiens] 114 2e-25
gi|4504005 gap junction protein, beta 1, 32kDa [Homo sapiens] 114 2e-25
gi|159032020 gap junction protein, beta 6 [Homo sapiens] 112 7e-25
gi|158966714 gap junction protein, beta 6 [Homo sapiens] 112 7e-25
gi|158966717 gap junction protein, beta 6 [Homo sapiens] 112 7e-25
gi|40254837 gap junction protein, beta 6 [Homo sapiens] 112 7e-25
gi|148839378 gap junction protein, delta 3, 31.9kDa [Homo sapiens] 111 1e-24
gi|38348412 gap junction protein, beta 7, 25kDa [Homo sapiens] 111 1e-24
gi|31559821 gap junction protein, gamma 3, 30.2kDa [Homo sapiens] 110 3e-24
gi|54607056 connexin 31 [Homo sapiens] 107 2e-23
gi|13128960 connexin 31 [Homo sapiens] 107 2e-23
gi|10835079 gap junction protein, beta 5, 31.1kDa [Homo sapiens] 107 2e-23
gi|169171704 PREDICTED: similar to hCG1770601 [Homo sapiens] 106 5e-23
gi|169171845 PREDICTED: similar to hCG1770601 [Homo sapiens] 106 5e-23
gi|169171183 PREDICTED: similar to hCG1770601 [Homo sapiens] 106 5e-23
>gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens]
Length = 439
Score = 898 bits (2321), Expect = 0.0
Identities = 439/439 (100%), Positives = 439/439 (100%)
Query: 1 MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQ 60
MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQ
Sbjct: 1 MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQ 60
Query: 61 PGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGP 120
PGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGP
Sbjct: 61 PGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGP 120
Query: 121 RRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTK 180
RRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTK
Sbjct: 121 RRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTK 180
Query: 181 AVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVR 240
AVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVR
Sbjct: 181 AVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVR 240
Query: 241 PFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRG 300
PFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRG
Sbjct: 241 PFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRG 300
Query: 301 RRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRD 360
RRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRD
Sbjct: 301 RRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRD 360
Query: 361 GAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPR 420
GAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPR
Sbjct: 361 GAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAKPR 420
Query: 421 AGSEKGSASSRDGKTTVWI 439
AGSEKGSASSRDGKTTVWI
Sbjct: 421 AGSEKGSASSRDGKTTVWI 439
>gi|122939172 connexin 45 [Homo sapiens]
Length = 396
Score = 358 bits (918), Expect = 7e-99
Identities = 211/444 (47%), Positives = 265/444 (59%), Gaps = 56/444 (12%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
MSWSFLTRLLEEIHNHSTFVGK+WLTVL+VFRIVLTAVGGE+IY DEQ+KF CNT QPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQER-RRALRRRPGPRR 122
+NVCYDAFAPLSHVRFWVFQI++++TPSVMYLGYA+H++A+ E ++A R +P R
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
Query: 123 APRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAV 182
+ H E + EE+PM+ E E ++
Sbjct: 121 WKQ------HRALEETEEDNEEDPMMYPEMELESDK------------------------ 150
Query: 183 GADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPF 242
+ K P P +HDGRRRI+ +GLM++YV QL+AR FEV FL+GQY LYGF+V PF
Sbjct: 151 --ENKEQSQPKP--KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPF 206
Query: 243 FPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRR 302
+ CSR PCPH +DCF+SRPTEKT+FLL+MY V+ LCLLLN+ EM HLG G+ +D++ +R
Sbjct: 207 YVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKR 266
Query: 303 ---GPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALR 359
P + P P A P +A PD + A+ QN AN A Q +
Sbjct: 267 RELEDPGAYNYPFTWNTPSAPP--GYNIAVKPDQIQYTELSNAKIAYKQNKANTA-QEQQ 323
Query: 360 DGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAK- 418
G+ + D L A R A R A A Q P AK
Sbjct: 324 YGSHEENLPAD------LEALQREIRMA---QERLDLAVQA--YSHQNNPHGPREKKAKV 372
Query: 419 -PRAGSEKGSASSR--DGKTTVWI 439
+AGS K +ASS+ DGKT+VWI
Sbjct: 373 GSKAGSNKSTASSKSGDGKTSVWI 396
>gi|69122473 connexin 45 [Homo sapiens]
Length = 396
Score = 358 bits (918), Expect = 7e-99
Identities = 211/444 (47%), Positives = 265/444 (59%), Gaps = 56/444 (12%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
MSWSFLTRLLEEIHNHSTFVGK+WLTVL+VFRIVLTAVGGE+IY DEQ+KF CNT QPGC
Sbjct: 1 MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQER-RRALRRRPGPRR 122
+NVCYDAFAPLSHVRFWVFQI++++TPSVMYLGYA+H++A+ E ++A R +P R
Sbjct: 61 ENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMR 120
Query: 123 APRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAV 182
+ H E + EE+PM+ E E ++
Sbjct: 121 WKQ------HRALEETEEDNEEDPMMYPEMELESDK------------------------ 150
Query: 183 GADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPF 242
+ K P P +HDGRRRI+ +GLM++YV QL+AR FEV FL+GQY LYGF+V PF
Sbjct: 151 --ENKEQSQPKP--KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPF 206
Query: 243 FPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRR 302
+ CSR PCPH +DCF+SRPTEKT+FLL+MY V+ LCLLLN+ EM HLG G+ +D++ +R
Sbjct: 207 YVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKR 266
Query: 303 ---GPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALR 359
P + P P A P +A PD + A+ QN AN A Q +
Sbjct: 267 RELEDPGAYNYPFTWNTPSAPP--GYNIAVKPDQIQYTELSNAKIAYKQNKANTA-QEQQ 323
Query: 360 DGAAAGDRDRDSSPCVGLPAASRGPPRAGAPASRTGSATSAGTVGEQGRPGTHERPGAK- 418
G+ + D L A R A R A A Q P AK
Sbjct: 324 YGSHEENLPAD------LEALQREIRMA---QERLDLAVQA--YSHQNNPHGPREKKAKV 372
Query: 419 -PRAGSEKGSASSR--DGKTTVWI 439
+AGS K +ASS+ DGKT+VWI
Sbjct: 373 GSKAGSNKSTASSKSGDGKTSVWI 396
>gi|55953076 connexin 50 [Homo sapiens]
Length = 433
Score = 224 bits (572), Expect = 9e-59
Identities = 117/295 (39%), Positives = 165/295 (55%), Gaps = 62/295 (21%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
WSFL +LEE++ HST +G+VWLTVL +FRI++ E ++ DEQ+ F CNT+QPGC+N
Sbjct: 4 WSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCEN 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPR 125
VCYD P+SH+R WV QI+ +STPS+MY+G+AVH R E+ + R
Sbjct: 64 VCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVH-YVRMEEKRKSR------------- 109
Query: 126 AHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGAD 185
E EE G G G ++ K
Sbjct: 110 -----------------------------EAEELGQQAGT-----NGGPDQGSVK----- 130
Query: 186 GKAAGTPGPTGQHDGRRRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFP 244
K++G+ G ++ + EG L+R Y+ ++ + FEV F+VG Y LYGF + P +
Sbjct: 131 -KSSGS-------KGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPLYR 182
Query: 245 CSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVR 299
CSR PCP+VVDCFVSRPTEKT+F+L M V+ + L LN+ E+ HLGL + A++
Sbjct: 183 CSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALK 237
>gi|10190698 gap junction protein, delta 2, 36kDa [Homo sapiens]
Length = 321
Score = 222 bits (566), Expect = 5e-58
Identities = 125/299 (41%), Positives = 177/299 (59%), Gaps = 20/299 (6%)
Query: 6 WSFLTRLLEE-IHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCD 64
W+ L RLLE + HST +G++ LTV+V+FRI++ A+ GE +Y DEQ F CNT QPGC+
Sbjct: 4 WTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQPGCN 63
Query: 65 NVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAP 124
CYD P+SH+R+WVFQI+++ TPS+ ++ Y+VH+ A+ ++ERR + R
Sbjct: 64 QACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAK--QRERRYSTVFLALDRD-- 119
Query: 125 RAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEE-ETGAAEGAGEEAEEAGAEEACTKAVG 183
PP G P G G G+ E+++ + G + E E T+
Sbjct: 120 ----PPESIGGPGGTGGGGS----GGGKREDKKLQNAIVNGVLQNTENTSKE---TEPDC 168
Query: 184 ADGKAAGTPGPTGQHDGRRRIQR--EGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRP 241
+ K TP P+G + R EG+ R Y+ Q+V R A E+ FLVGQY LYGF V
Sbjct: 169 LEVKEL-TPHPSGLRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPG 227
Query: 242 FFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRG 300
+ C+R PC V+C+VSRPTEKTVFL+ M+ VS +C++LNL E+ HLG + AVRG
Sbjct: 228 LYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRG 286
>gi|14211941 gap junction protein, alpha 10 [Homo sapiens]
Length = 543
Score = 218 bits (555), Expect = 9e-57
Identities = 116/313 (37%), Positives = 178/313 (56%), Gaps = 71/313 (22%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
W+ L +LEE+H+HST VGK+WLT+L +FR+++ V E ++ DEQ+ F CNTRQPGC+N
Sbjct: 4 WNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPGCNN 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPR 125
+CYD P+S +RFWV QI+ +S+PS++Y+G+A++RL RA E++R+R +
Sbjct: 64 ICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRL-RAFEKDRQR-----------KK 111
Query: 126 AHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGAD 185
+HL E P L L E++ + E EE
Sbjct: 112 SHLRAQ-----------MENPDLDLEEQQRIDR-----------ELRRLEE--------- 140
Query: 186 GKAAGTPGPTGQHDGRRRIQREGL----MRVYVAQLVARAAFEVAFLVGQYLLYGFEVRP 241
++RI + L +R YV ++ R+ EV F++GQY+LYGF++ P
Sbjct: 141 ---------------QKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYGFQMHP 185
Query: 242 FFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGL---------G 292
+ C++ PCP+ VDCFVSRPTEKT+F+L M+ ++ + LLLN+ E+ HLG+
Sbjct: 186 LYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRTLYKK 245
Query: 293 SAQDAVRGRRGPP 305
S+ + + GPP
Sbjct: 246 SSSEGIEDETGPP 258
>gi|62865885 connexin 37 [Homo sapiens]
Length = 333
Score = 217 bits (553), Expect = 1e-56
Identities = 141/399 (35%), Positives = 198/399 (49%), Gaps = 79/399 (19%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
W FL +LL+++ HST VGK+WLTVL +FRI++ + GE+++ DEQ+ F CNT QPGC N
Sbjct: 4 WGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTN 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPR 125
VCYD P+SH+R+WV Q + +STP+++YLG+ ++ L+R E+ LR++ G RA
Sbjct: 64 VCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIY-LSRREER-----LRQKEGELRA-- 115
Query: 126 AHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGAD 185
L ++P + E A E K A+
Sbjct: 116 ---------------LPAKDPQV-------------------ERALAAVERQMAKISVAE 141
Query: 186 GKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPC 245
DGR RI R LM YVA ++ ++ E FL GQ+ LYG+ + P F C
Sbjct: 142 -------------DGRLRI-RGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVC 187
Query: 246 SRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRG-- 303
R PCP++VDCFVSRPTEKT+F++ M VV + L+LNL E+ HL +R R+G
Sbjct: 188 QRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQD 247
Query: 304 -PPASAPAPAPRPPPCAF-PAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDG 361
PP + P F G + PP + +QN ANL +
Sbjct: 248 APPTQGTSSDPYTDQVFFYLPVGQGPSSPP-----CPTYNGLSSSEQNWANLTTE----- 297
Query: 362 AAAGDRDRDSSPCVGLPAASRGPPRAG-APASRTGSATS 399
+R S P P PP+ G P SR S+ S
Sbjct: 298 ----ERLASSRP----PLFLDPPPQNGQKPPSRPSSSAS 328
>gi|32483412 connexin 40 [Homo sapiens]
Length = 358
Score = 201 bits (511), Expect = 1e-51
Identities = 114/286 (39%), Positives = 155/286 (54%), Gaps = 60/286 (20%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
WSFL LEE+H HST VGKVWLTVL +FR+++ E+ + DEQA F C+T QPGC N
Sbjct: 4 WSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQN 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPR 125
VCYD P+SH+R+WV QI+ +STPS++Y+G+A+H + QE+R+ R A R
Sbjct: 64 VCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRM---QEKRKL-------REAER 113
Query: 126 AHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAE-GAGEEAEEAGAEEACTKAVGA 184
A +E +G+ E E+AE + EE
Sbjct: 114 A---------------------------KEVRGSGSYEYPVAEKAELSCWEEG------- 139
Query: 185 DGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFP 244
+GR +Q L+ YV ++ R EV F+VGQY +YG +
Sbjct: 140 --------------NGRIALQGT-LLNTYVCSILIRTTMEVGFIVGQYFIYGIFLTTLHV 184
Query: 245 CSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLG 290
C R PCPH V+C+VSRPTEK VF++ M V+ L LLL+L E+ HLG
Sbjct: 185 CRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLG 230
>gi|6631083 connexin 40 [Homo sapiens]
Length = 358
Score = 201 bits (511), Expect = 1e-51
Identities = 114/286 (39%), Positives = 155/286 (54%), Gaps = 60/286 (20%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
WSFL LEE+H HST VGKVWLTVL +FR+++ E+ + DEQA F C+T QPGC N
Sbjct: 4 WSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPGCQN 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPR 125
VCYD P+SH+R+WV QI+ +STPS++Y+G+A+H + QE+R+ R A R
Sbjct: 64 VCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRM---QEKRKL-------REAER 113
Query: 126 AHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAE-GAGEEAEEAGAEEACTKAVGA 184
A +E +G+ E E+AE + EE
Sbjct: 114 A---------------------------KEVRGSGSYEYPVAEKAELSCWEEG------- 139
Query: 185 DGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFP 244
+GR +Q L+ YV ++ R EV F+VGQY +YG +
Sbjct: 140 --------------NGRIALQGT-LLNTYVCSILIRTTMEVGFIVGQYFIYGIFLTTLHV 184
Query: 245 CSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLG 290
C R PCPH V+C+VSRPTEK VF++ M V+ L LLL+L E+ HLG
Sbjct: 185 CRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLG 230
>gi|4504001 connexin 43 [Homo sapiens]
Length = 382
Score = 201 bits (511), Expect = 1e-51
Identities = 122/377 (32%), Positives = 184/377 (48%), Gaps = 76/377 (20%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
WS L +LL+++ +ST GKVWL+VL +FRI+L E+ + DEQ+ F CNT+QPGC+N
Sbjct: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPR 125
VCYD P+SHVRFWV QI+ +S P+++YL + + + + +
Sbjct: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEK------------------ 105
Query: 126 AHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTK-AVGA 184
L ++EEE + +G + E K +
Sbjct: 106 ------------------------LNKKEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEE 141
Query: 185 DGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFP 244
GK R GL+R Y+ ++ ++ FEVAFL+ Q+ +YGF + +
Sbjct: 142 HGKVK---------------MRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAVYT 186
Query: 245 CSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGP 304
C R PCPH VDCF+SRPTEKT+F++ M VVS + L LN+ E+ ++ +D V+G+ P
Sbjct: 187 CKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDP 246
Query: 305 -PASAPAPAPRPP----------PCAFPAAAAGLACPPDYSLVVRAAERA-------RAH 346
A++ A +P C+ P A PP Y LV + +A
Sbjct: 247 YHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQAS 306
Query: 347 DQNLANLALQALRDGAA 363
+QN AN + + R G A
Sbjct: 307 EQNWANYSAEQNRMGQA 323
>gi|145699105 connexin40.1 [Homo sapiens]
Length = 370
Score = 154 bits (389), Expect = 2e-37
Identities = 94/296 (31%), Positives = 136/296 (45%), Gaps = 72/296 (24%)
Query: 12 LLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAF 71
L+ ++ + T VGK+W + ++ R+++ + G +Y DEQ +F CNT QPGC NVCYD F
Sbjct: 10 LIITLNCNVTMVGKLWFVLTMLLRMLVIVLAGRPVYQDEQERFVCNTLQPGCANVCYDVF 69
Query: 72 APLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPRAHLPPP 131
+P+SH+RFW+ Q V + PS ++ Y +HR A + GPRR P
Sbjct: 70 SPVSHLRFWLIQGVCVLLPSAVFSVYVLHRGATLAAL----------GPRRCP------- 112
Query: 132 HAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGADGKAAGT 191
+ E A + C
Sbjct: 113 -----------------------------------DPREPASGQRRC------------- 124
Query: 192 PGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCP 251
P P G+ G +Q Y+ L+ R E AF Y L+GF FPC+R PC
Sbjct: 125 PRPFGERGG---LQVPDFSAGYIIHLLLRTLLEAAFGALHYFLFGFLAPKKFPCTRPPCT 181
Query: 252 HVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPAS 307
VVDC+VSRPTEK++ +L ++ VS L LL L ++ + S + +R R GPP S
Sbjct: 182 GVVDCYVSRPTEKSLLMLFLWAVSALSFLLGLADL----VCSLRRRMRRRPGPPTS 233
Score = 30.4 bits (67), Expect = 3.3
Identities = 23/73 (31%), Positives = 29/73 (39%), Gaps = 7/73 (9%)
Query: 111 RRALRRRPGPRRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAE 170
RR +RRRPGP +P +G E EE EEE A GA E
Sbjct: 221 RRRMRRRPGPPTSPSIRKQSGASGHAEGRRTDEE-------GGREEEGAPAPPGARAGGE 273
Query: 171 EAGAEEACTKAVG 183
AG+ ++ G
Sbjct: 274 GAGSPRRTSRVSG 286
>gi|22779877 connexin 46 [Homo sapiens]
Length = 435
Score = 142 bits (359), Expect = 5e-34
Identities = 106/288 (36%), Positives = 136/288 (47%), Gaps = 27/288 (9%)
Query: 167 EEAEEAGAEEACTKAVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVA 226
EE ++ EE K K P+ + D R L+R YV ++ + FEV
Sbjct: 103 EEKKKEREEEEQLKRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVG 162
Query: 227 FLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEM 286
F+ GQY LYGFE++P + C R PCP+ VDCF+SRPTEKT+F++ M V+C LLLN+ E+
Sbjct: 163 FIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEI 222
Query: 287 AHLGLGSAQDAVRGRRGPPAS-APA----PAPRPPPCAFPAAAAGLACPPDYSLVVRAAE 341
HLG + V R GP AS AP P P PP PA A G PP Y+
Sbjct: 223 YHLGWKKLKQGVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGF--PPYYAHTAAPLG 280
Query: 342 RARA-----HDQNLANLALQALRDGAAAGDRDRDSSPCVGL---------PAASRGPPRA 387
+ARA A+ L AL + G + + L AA R PP
Sbjct: 281 QARAVGYPGAPPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPAL 340
Query: 388 GA-PASRTGSATSAGTVGEQGRPGTHE-RPGAKPRAGSEKGSASSRDG 433
A PA+ T +A S VG P HE GA P GS SS +G
Sbjct: 341 KAYPAASTPAAPS--PVGSSSPPLAHEAEAGAAPLL--LDGSGSSLEG 384
Score = 141 bits (355), Expect = 1e-33
Identities = 62/125 (49%), Positives = 86/125 (68%), Gaps = 6/125 (4%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
WSFL RLLE HST +GKVWLTVL +FRI++ E ++ DEQ+ FTCNT+QPGC+N
Sbjct: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCEN 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRR-----ALRRRPGP 120
VCYD P+SH+RFW QI+ +STP+++YLG+ +H + R E+++ R R P P
Sbjct: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLH-IVRMEEKKKEREEEEQLKRESPSP 122
Query: 121 RRAPR 125
+ P+
Sbjct: 123 KEPPQ 127
>gi|31542845 gap junction protein, alpha 9, 59kDa [Homo sapiens]
Length = 515
Score = 130 bits (328), Expect = 2e-30
Identities = 54/107 (50%), Positives = 82/107 (76%), Gaps = 1/107 (0%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
W+ L LEE+H HST +GK+WLT+L +FR+++ V E +++DEQ+ F CNT QPGC N
Sbjct: 4 WNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPGCRN 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRR 112
VCYD P+S +R+WV Q++ +S+PS++Y+G+A++RL R E+ER+R
Sbjct: 64 VCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRL-RVLEEERQR 109
Score = 103 bits (256), Expect = 4e-22
Identities = 45/96 (46%), Positives = 63/96 (65%)
Query: 206 REGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKT 265
R L+ YV + R+ EV F++GQYLLYGF + P F C PCP+++DCFVSRPTEKT
Sbjct: 150 RGTLLCTYVIHIFTRSVVEVGFMIGQYLLYGFHLEPLFKCHGHPCPNIIDCFVSRPTEKT 209
Query: 266 VFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGR 301
+FLL M ++ + L LN+ E+ HLG + + G+
Sbjct: 210 IFLLFMQSIATISLFLNILEIFHLGFKKIKRGLWGK 245
>gi|42558283 gap junction protein beta 2 [Homo sapiens]
Length = 226
Score = 116 bits (291), Expect = 4e-26
Identities = 49/108 (45%), Positives = 73/108 (67%), Gaps = 3/108 (2%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M W L +L ++ HST +GK+WLTVL +FRI++ V + ++ DEQA F CNT QPGC
Sbjct: 1 MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERR 111
NVCYD + P+SH+R W Q++ +STP+++ A+H R E++R+
Sbjct: 61 KNVCYDHYFPISHIRLWALQLIFVSTPALL---VAMHVAYRRHEKKRK 105
Score = 81.3 bits (199), Expect = 2e-15
Identities = 40/90 (44%), Positives = 59/90 (65%), Gaps = 2/90 (2%)
Query: 202 RRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSRQPCPHVVDCFVS 259
++++ EG L Y + + R FE AF+ Y++Y GF ++ C+ PCP+ VDCFVS
Sbjct: 124 QKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVS 183
Query: 260 RPTEKTVFLLVMYVVSCLCLLLNLCEMAHL 289
RPTEKTVF + M VS +C+LLN+ E+ +L
Sbjct: 184 RPTEKTVFTVFMIAVSGICILLNVTELCYL 213
>gi|23397464 gap junction protein, beta 4 [Homo sapiens]
Length = 266
Score = 116 bits (290), Expect = 5e-26
Identities = 47/115 (40%), Positives = 78/115 (67%), Gaps = 4/115 (3%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M+W+FL LL ++ +ST + ++WL+V+ +FR+++ V E ++ DEQ F CNT+QPGC
Sbjct: 1 MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRP 118
NVCYD F P+SHVR W Q+++++ PS++ + + +R E+ER+ L+ P
Sbjct: 61 PNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYR----EERERKHHLKHGP 111
Score = 74.7 bits (182), Expect = 2e-13
Identities = 36/86 (41%), Positives = 53/86 (61%), Gaps = 1/86 (1%)
Query: 205 QREGLMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSRQPCPHVVDCFVSRPTE 263
+R GL Y+ L+ +AA + FL + LY +++ CS +PCPH VDC++SRPTE
Sbjct: 123 KRGGLWWTYLLSLIFKAAVDAGFLYIFHRLYKDYDMPRVVACSVEPCPHTVDCYISRPTE 182
Query: 264 KTVFLLVMYVVSCLCLLLNLCEMAHL 289
K VF M + +C+LLNL E+ +L
Sbjct: 183 KKVFTYFMVTTAAICILLNLSEVFYL 208
>gi|148233402 gap junction protein, beta 1, 32kDa [Homo sapiens]
Length = 283
Score = 114 bits (284), Expect = 2e-25
Identities = 44/98 (44%), Positives = 72/98 (73%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M+W+ L LL ++ HST +G+VWL+V+ +FRI++ V E+++ DE++ F CNT QPGC
Sbjct: 1 MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHR 101
++VCYD F P+SHVR W Q++++STP+++ + H+
Sbjct: 61 NSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQ 98
Score = 80.9 bits (198), Expect = 2e-15
Identities = 43/108 (39%), Positives = 61/108 (56%), Gaps = 2/108 (1%)
Query: 201 RRRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSRQPCPHVVDCFV 258
R ++ G L YV +V R FE F+ YLLY G+ + C PCP+ VDCFV
Sbjct: 122 RHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVYPCPNTVDCFV 181
Query: 259 SRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPA 306
SRPTEKTVF + M S +C++LN+ E+ +L + + + R PP+
Sbjct: 182 SRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPS 229
>gi|4504005 gap junction protein, beta 1, 32kDa [Homo sapiens]
Length = 283
Score = 114 bits (284), Expect = 2e-25
Identities = 44/98 (44%), Positives = 72/98 (73%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M+W+ L LL ++ HST +G+VWL+V+ +FRI++ V E+++ DE++ F CNT QPGC
Sbjct: 1 MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHR 101
++VCYD F P+SHVR W Q++++STP+++ + H+
Sbjct: 61 NSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQ 98
Score = 80.9 bits (198), Expect = 2e-15
Identities = 43/108 (39%), Positives = 61/108 (56%), Gaps = 2/108 (1%)
Query: 201 RRRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSRQPCPHVVDCFV 258
R ++ G L YV +V R FE F+ YLLY G+ + C PCP+ VDCFV
Sbjct: 122 RHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVYPCPNTVDCFV 181
Query: 259 SRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGPPA 306
SRPTEKTVF + M S +C++LN+ E+ +L + + + R PP+
Sbjct: 182 SRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPS 229
>gi|159032020 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 112 bits (280), Expect = 7e-25
Identities = 46/112 (41%), Positives = 70/112 (62%), Gaps = 3/112 (2%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M W L + ++ HST +GKVW+TV+ +FR+++ V + ++ DEQ F CNT QPGC
Sbjct: 1 MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSV---MYLGYAVHRLARASEQERRR 112
NVCYD F P+SH+R W Q++ +STP++ M++ Y H R + +R
Sbjct: 61 KNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKR 112
Score = 77.8 bits (190), Expect = 2e-14
Identities = 38/91 (41%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Query: 201 RRRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSRQPCPHVVDCFV 258
+++++ EG L Y + + R FE AF+ Y LY G+ + C PCP++VDCF+
Sbjct: 123 KQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFI 182
Query: 259 SRPTEKTVFLLVMYVVSCLCLLLNLCEMAHL 289
SRPTEKTVF + M S +C+LLN+ E+ +L
Sbjct: 183 SRPTEKTVFTIFMISASVICMLLNVAELCYL 213
>gi|158966714 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 112 bits (280), Expect = 7e-25
Identities = 46/112 (41%), Positives = 70/112 (62%), Gaps = 3/112 (2%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M W L + ++ HST +GKVW+TV+ +FR+++ V + ++ DEQ F CNT QPGC
Sbjct: 1 MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSV---MYLGYAVHRLARASEQERRR 112
NVCYD F P+SH+R W Q++ +STP++ M++ Y H R + +R
Sbjct: 61 KNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKR 112
Score = 77.8 bits (190), Expect = 2e-14
Identities = 38/91 (41%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Query: 201 RRRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSRQPCPHVVDCFV 258
+++++ EG L Y + + R FE AF+ Y LY G+ + C PCP++VDCF+
Sbjct: 123 KQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFI 182
Query: 259 SRPTEKTVFLLVMYVVSCLCLLLNLCEMAHL 289
SRPTEKTVF + M S +C+LLN+ E+ +L
Sbjct: 183 SRPTEKTVFTIFMISASVICMLLNVAELCYL 213
>gi|158966717 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 112 bits (280), Expect = 7e-25
Identities = 46/112 (41%), Positives = 70/112 (62%), Gaps = 3/112 (2%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M W L + ++ HST +GKVW+TV+ +FR+++ V + ++ DEQ F CNT QPGC
Sbjct: 1 MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSV---MYLGYAVHRLARASEQERRR 112
NVCYD F P+SH+R W Q++ +STP++ M++ Y H R + +R
Sbjct: 61 KNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKR 112
Score = 77.8 bits (190), Expect = 2e-14
Identities = 38/91 (41%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Query: 201 RRRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSRQPCPHVVDCFV 258
+++++ EG L Y + + R FE AF+ Y LY G+ + C PCP++VDCF+
Sbjct: 123 KQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFI 182
Query: 259 SRPTEKTVFLLVMYVVSCLCLLLNLCEMAHL 289
SRPTEKTVF + M S +C+LLN+ E+ +L
Sbjct: 183 SRPTEKTVFTIFMISASVICMLLNVAELCYL 213
>gi|40254837 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 112 bits (280), Expect = 7e-25
Identities = 46/112 (41%), Positives = 70/112 (62%), Gaps = 3/112 (2%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M W L + ++ HST +GKVW+TV+ +FR+++ V + ++ DEQ F CNT QPGC
Sbjct: 1 MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSV---MYLGYAVHRLARASEQERRR 112
NVCYD F P+SH+R W Q++ +STP++ M++ Y H R + +R
Sbjct: 61 KNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKR 112
Score = 77.8 bits (190), Expect = 2e-14
Identities = 38/91 (41%), Positives = 57/91 (62%), Gaps = 2/91 (2%)
Query: 201 RRRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSRQPCPHVVDCFV 258
+++++ EG L Y + + R FE AF+ Y LY G+ + C PCP++VDCF+
Sbjct: 123 KQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFI 182
Query: 259 SRPTEKTVFLLVMYVVSCLCLLLNLCEMAHL 289
SRPTEKTVF + M S +C+LLN+ E+ +L
Sbjct: 183 SRPTEKTVFTIFMISASVICMLLNVAELCYL 213
>gi|148839378 gap junction protein, delta 3, 31.9kDa [Homo sapiens]
Length = 294
Score = 111 bits (278), Expect = 1e-24
Identities = 45/99 (45%), Positives = 69/99 (69%)
Query: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
W+FL LL+ + S VG++WL V+++FRI++ A G A++ DEQ +F CNT QPGC
Sbjct: 4 WAFLGSLLDAVQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQPGCRQ 63
Query: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLAR 104
CYD P+SH RFW+F I+++S P V+++ Y++HR +
Sbjct: 64 TCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGK 102
Score = 105 bits (262), Expect = 8e-23
Identities = 65/164 (39%), Positives = 81/164 (49%), Gaps = 9/164 (5%)
Query: 180 KAVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEV 239
+A GA+ A PG ++ R Y+ + R E+ FL GQ LLYGF V
Sbjct: 103 EAGGAEAAAQCAPGLPEAQCAPCALRARRARRCYLLSVALRLLAELTFLGGQALLYGFRV 162
Query: 240 RPFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAH-LGLGSAQDAV 298
P F C+ PCPH VDCFVSRPTEKTVF+L + V L LL++ E+ H L G +
Sbjct: 163 APHFACAGPPCPHTVDCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKGRPRAGE 222
Query: 299 RGRRGPPAS------APAPAPRPPPCAFPAAAAG--LACPPDYS 334
R R A P P P PPP A P+ G PP Y+
Sbjct: 223 RDNRCNRAHEEAQKLLPPPPPPPPPPALPSRRPGPEPCAPPAYA 266
>gi|38348412 gap junction protein, beta 7, 25kDa [Homo sapiens]
Length = 223
Score = 111 bits (277), Expect = 1e-24
Identities = 50/116 (43%), Positives = 75/116 (64%), Gaps = 2/116 (1%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
MSW FL LL ++ +ST G +WL V+ VFR+++ V E ++ DEQ +F CN+RQPGC
Sbjct: 1 MSWMFLRDLLSGVNKYSTGTGWIWLAVVFVFRLLVYMVAAEHVWKDEQKEFECNSRQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPG 119
NVC+D F P+S VR W Q++++STPS++ + + + R E+ R+ L PG
Sbjct: 61 KNVCFDDFFPISQVRLWALQLIMVSTPSLLVVLHVAYHEGR--EKRHRKKLYVSPG 114
Score = 90.5 bits (223), Expect = 3e-18
Identities = 44/106 (41%), Positives = 63/106 (59%), Gaps = 12/106 (11%)
Query: 198 HDGRRRIQRE-----------GLMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPC 245
H+GR + R+ GL Y+ L+ + FE+ FLV Y LY GF V C
Sbjct: 98 HEGREKRHRKKLYVSPGTMDGGLWYAYLISLIVKTGFEIGFLVLFYKLYDGFSVPYLIKC 157
Query: 246 SRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGL 291
+PCP+ VDCF+S+PTEKT+F+L + + SCLC++LN E++ L L
Sbjct: 158 DLKPCPNTVDCFISKPTEKTIFILFLVITSCLCIVLNFIELSFLVL 203
>gi|31559821 gap junction protein, gamma 3, 30.2kDa [Homo sapiens]
Length = 279
Score = 110 bits (274), Expect = 3e-24
Identities = 48/99 (48%), Positives = 70/99 (70%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M FL RLL E ST VG++ L VL+ FR+VL A G +Y DEQ++F C+T+QPGC
Sbjct: 1 MCGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRL 102
C+DAF PLS +RFWVFQ+++++ PS +Y+G+ ++ +
Sbjct: 61 KAACFDAFHPLSPLRFWVFQVILVAVPSALYMGFTLYHV 99
Score = 79.3 bits (194), Expect = 6e-15
Identities = 42/84 (50%), Positives = 52/84 (61%)
Query: 209 LMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFPCSRQPCPHVVDCFVSRPTEKTVFL 268
L+ YVAQL AR E A L QY LYGF++ F C R+PC + C +SRP+EKT+FL
Sbjct: 133 LLWAYVAQLGARLVLEGAALGLQYHLYGFQMPSSFACRREPCLGSITCNLSRPSEKTIFL 192
Query: 269 LVMYVVSCLCLLLNLCEMAHLGLG 292
M+ VS CLL E+ LGLG
Sbjct: 193 KTMFGVSGFCLLFTFLELVLLGLG 216
>gi|54607056 connexin 31 [Homo sapiens]
Length = 270
Score = 107 bits (268), Expect = 2e-23
Identities = 46/120 (38%), Positives = 76/120 (63%), Gaps = 6/120 (5%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M W L LL ++ +ST G++WL+V+ VFR+++ V E ++ DEQ F CNT+QPGC
Sbjct: 1 MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRA 123
NVCYD + P+S++R W Q++ ++ PS++ + + +R +ER R R++ G + A
Sbjct: 61 TNVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYR------EERERRHRQKHGDQCA 114
Score = 65.9 bits (159), Expect = 7e-11
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 7/108 (6%)
Query: 208 GLMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSR-QPCPHVVDCFVSRPTEKT 265
GL Y+ L+ + E FL + L+ GF + C+ PCP++VDC+++RPTEK
Sbjct: 126 GLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKK 185
Query: 266 VFLLVMYVVSCLCLLLNLCEMAHLGL-----GSAQDAVRGRRGPPASA 308
+F M S +C++L +CE+ +L G +D RG P +SA
Sbjct: 186 IFTYFMVGASAVCIVLTICELCYLICHRVLRGLHKDKPRGGCSPSSSA 233
>gi|13128960 connexin 31 [Homo sapiens]
Length = 270
Score = 107 bits (268), Expect = 2e-23
Identities = 46/120 (38%), Positives = 76/120 (63%), Gaps = 6/120 (5%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M W L LL ++ +ST G++WL+V+ VFR+++ V E ++ DEQ F CNT+QPGC
Sbjct: 1 MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRA 123
NVCYD + P+S++R W Q++ ++ PS++ + + +R +ER R R++ G + A
Sbjct: 61 TNVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYR------EERERRHRQKHGDQCA 114
Score = 65.9 bits (159), Expect = 7e-11
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 7/108 (6%)
Query: 208 GLMRVYVAQLVARAAFEVAFLVGQYLLY-GFEVRPFFPCSR-QPCPHVVDCFVSRPTEKT 265
GL Y+ L+ + E FL + L+ GF + C+ PCP++VDC+++RPTEK
Sbjct: 126 GLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKK 185
Query: 266 VFLLVMYVVSCLCLLLNLCEMAHLGL-----GSAQDAVRGRRGPPASA 308
+F M S +C++L +CE+ +L G +D RG P +SA
Sbjct: 186 IFTYFMVGASAVCIVLTICELCYLICHRVLRGLHKDKPRGGCSPSSSA 233
>gi|10835079 gap junction protein, beta 5, 31.1kDa [Homo sapiens]
Length = 273
Score = 107 bits (267), Expect = 2e-23
Identities = 46/124 (37%), Positives = 76/124 (61%), Gaps = 5/124 (4%)
Query: 4 MSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGC 63
M+WS LL ++ +ST G++WL+++ +FR+++ V E ++SD+ F CNTRQPGC
Sbjct: 1 MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGC 60
Query: 64 DNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLA-----RASEQERRRALRRRP 118
NVC+D F P+SHVR W Q+++++ PS++ + + +R R + E L P
Sbjct: 61 SNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNP 120
Query: 119 GPRR 122
G +R
Sbjct: 121 GKKR 124
Score = 77.4 bits (189), Expect = 2e-14
Identities = 39/112 (34%), Positives = 64/112 (57%), Gaps = 5/112 (4%)
Query: 196 GQHDGRRRI----QREGLMRVYVAQLVARAAFEVAFLVGQYLLYG-FEVRPFFPCSRQPC 250
G++ GR + +R GL YV LV +A+ ++AFL + Y + + P C PC
Sbjct: 110 GENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPC 169
Query: 251 PHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRR 302
P++VDCF+S+P+EK +F L M + +C+LLNL E+ +L + + R+
Sbjct: 170 PNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARK 221
>gi|169171704 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 106 bits (264), Expect = 5e-23
Identities = 58/129 (44%), Positives = 77/129 (59%), Gaps = 12/129 (9%)
Query: 12 LLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAF 71
LL E HST VG++ VL+ FR+VL A G +Y DEQ++F C+T+QPGC C+DAF
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 72 APLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGP----RRAPRAH 127
PLS +RFWVFQ+++++ PSV+Y+GY +E R GP RAPR
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGYTPWESGVFQYREPPRC-----GPSEVLERAPR-- 140
Query: 128 LPPPHAGWP 136
PP A P
Sbjct: 141 -PPAPATLP 148
>gi|169171845 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 106 bits (264), Expect = 5e-23
Identities = 58/129 (44%), Positives = 77/129 (59%), Gaps = 12/129 (9%)
Query: 12 LLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAF 71
LL E HST VG++ VL+ FR+VL A G +Y DEQ++F C+T+QPGC C+DAF
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 72 APLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGP----RRAPRAH 127
PLS +RFWVFQ+++++ PSV+Y+GY +E R GP RAPR
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGYTPWESGVFQYREPPRC-----GPSEVLERAPR-- 140
Query: 128 LPPPHAGWP 136
PP A P
Sbjct: 141 -PPAPATLP 148
>gi|169171183 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 106 bits (264), Expect = 5e-23
Identities = 58/129 (44%), Positives = 77/129 (59%), Gaps = 12/129 (9%)
Query: 12 LLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDNVCYDAF 71
LL E HST VG++ VL+ FR+VL A G +Y DEQ++F C+T+QPGC C+DAF
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 72 APLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGP----RRAPRAH 127
PLS +RFWVFQ+++++ PSV+Y+GY +E R GP RAPR
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGYTPWESGVFQYREPPRC-----GPSEVLERAPR-- 140
Query: 128 LPPPHAGWP 136
PP A P
Sbjct: 141 -PPAPATLP 148
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,094,380
Number of Sequences: 37866
Number of extensions: 1224646
Number of successful extensions: 23112
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 293
Number of HSP's successfully gapped in prelim test: 682
Number of HSP's that attempted gapping in prelim test: 14096
Number of HSP's gapped (non-prelim): 7603
length of query: 439
length of database: 18,247,518
effective HSP length: 105
effective length of query: 334
effective length of database: 14,271,588
effective search space: 4766710392
effective search space used: 4766710392
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.