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Search of human proteins with 45331213
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45331213 RAN binding protein 6 [Homo sapiens]
(1105 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45331213 RAN binding protein 6 [Homo sapiens] 2204 0.0
gi|24797086 importin 5 [Homo sapiens] 1788 0.0
gi|62460637 importin 4 [Homo sapiens] 151 4e-36
gi|23510381 transportin 1 isoform 2 [Homo sapiens] 69 2e-11
gi|133925811 transportin 1 isoform 1 [Homo sapiens] 69 2e-11
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso... 65 3e-10
gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso... 65 3e-10
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof... 65 3e-10
gi|19923142 karyopherin beta 1 [Homo sapiens] 57 1e-07
gi|145587088 hypothetical protein LOC165186 [Homo sapiens] 35 0.39
gi|109715835 HEAT repeat containing 6 [Homo sapiens] 35 0.51
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 33 1.1
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 33 1.1
gi|25092658 hypothetical protein LOC221927 [Homo sapiens] 32 3.3
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 32 4.3
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 32 4.3
gi|27477070 BTAF1 RNA polymerase II, B-TFIID transcription facto... 32 4.3
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [... 31 5.7
gi|109240544 zinc finger protein 596 [Homo sapiens] 31 7.4
gi|109240542 zinc finger protein 596 [Homo sapiens] 31 7.4
gi|109240540 zinc finger protein 596 [Homo sapiens] 31 7.4
gi|73695475 protein BAP28 [Homo sapiens] 30 9.7
>gi|45331213 RAN binding protein 6 [Homo sapiens]
Length = 1105
Score = 2204 bits (5712), Expect = 0.0
Identities = 1105/1105 (100%), Positives = 1105/1105 (100%)
Query: 1 MAATASAGVPATVSEKQEFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVRNR 60
MAATASAGVPATVSEKQEFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVRNR
Sbjct: 1 MAATASAGVPATVSEKQEFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVRNR 60
Query: 61 RAGYEVRQMAAALLRRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDI 120
RAGYEVRQMAAALLRRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDI
Sbjct: 61 RAGYEVRQMAAALLRRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDI 120
Query: 121 FAVLARNLIDEDGTNHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDI 180
FAVLARNLIDEDGTNHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDI
Sbjct: 121 FAVLARNLIDEDGTNHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDI 180
Query: 181 IKRLLDQCIQDQEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQD 240
IKRLLDQCIQDQEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQD
Sbjct: 181 IKRLLDQCIQDQEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQD 240
Query: 241 DDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATP 300
DDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATP
Sbjct: 241 DDSVLESLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATP 300
Query: 301 MLKKHTNIIAQAVPHILAMMVDLQDDEDWVNADEMEEDDFDSNAVAAESALDRLACGLGG 360
MLKKHTNIIAQAVPHILAMMVDLQDDEDWVNADEMEEDDFDSNAVAAESALDRLACGLGG
Sbjct: 301 MLKKHTNIIAQAVPHILAMMVDLQDDEDWVNADEMEEDDFDSNAVAAESALDRLACGLGG 360
Query: 361 KVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPH 420
KVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPH
Sbjct: 361 KVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPH 420
Query: 421 PRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIED 480
PRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIED
Sbjct: 421 PRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIED 480
Query: 481 CPKSLLVLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYYD 540
CPKSLLVLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYYD
Sbjct: 481 CPKSLLVLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYYD 540
Query: 541 IFMPSLKHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLKTQSDLN 600
IFMPSLKHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLKTQSDLN
Sbjct: 541 IFMPSLKHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLKTQSDLN 600
Query: 601 NMEDDDPQTSYMVSAWARMCKILGKDFQQYLPLVIEPLIKTASAKPDVALLDTQDVENMS 660
NMEDDDPQTSYMVSAWARMCKILGKDFQQYLPLVIEPLIKTASAKPDVALLDTQDVENMS
Sbjct: 601 NMEDDDPQTSYMVSAWARMCKILGKDFQQYLPLVIEPLIKTASAKPDVALLDTQDVENMS 660
Query: 661 DDDGWQFVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKLMVPLLK 720
DDDGWQFVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKLMVPLLK
Sbjct: 661 DDDGWQFVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKLMVPLLK 720
Query: 721 FYFHDNVRVAAAESMPFLLECARIRGPEYLAQMWQFICDPLIKAIGTEPDTDVLSEIMNS 780
FYFHDNVRVAAAESMPFLLECARIRGPEYLAQMWQFICDPLIKAIGTEPDTDVLSEIMNS
Sbjct: 721 FYFHDNVRVAAAESMPFLLECARIRGPEYLAQMWQFICDPLIKAIGTEPDTDVLSEIMNS 780
Query: 781 FAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDED 840
FAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDED
Sbjct: 781 FAKSIEVMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDED 840
Query: 841 ECDVYILTKVSDILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDII 900
ECDVYILTKVSDILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDII
Sbjct: 841 ECDVYILTKVSDILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDII 900
Query: 901 EHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLV 960
EHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLV
Sbjct: 901 EHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLV 960
Query: 961 KVIKCANSKTKKNVIATENCISAIGKILKFKPNCVNVDEVLPHWLSWLPLHEDKEEAIQT 1020
KVIKCANSKTKKNVIATENCISAIGKILKFKPNCVNVDEVLPHWLSWLPLHEDKEEAIQT
Sbjct: 961 KVIKCANSKTKKNVIATENCISAIGKILKFKPNCVNVDEVLPHWLSWLPLHEDKEEAIQT 1020
Query: 1021 LSFLCDLIESNHPVVIGPNNSNLPKIISIIAEGKINETINYEDPCAKRLANVVRQVQTSE 1080
LSFLCDLIESNHPVVIGPNNSNLPKIISIIAEGKINETINYEDPCAKRLANVVRQVQTSE
Sbjct: 1021 LSFLCDLIESNHPVVIGPNNSNLPKIISIIAEGKINETINYEDPCAKRLANVVRQVQTSE 1080
Query: 1081 DLWLECVSQLDDEQQEALQELLNFA 1105
DLWLECVSQLDDEQQEALQELLNFA
Sbjct: 1081 DLWLECVSQLDDEQQEALQELLNFA 1105
>gi|24797086 importin 5 [Homo sapiens]
Length = 1115
Score = 1788 bits (4630), Expect = 0.0
Identities = 869/1099 (79%), Positives = 992/1099 (90%)
Query: 7 AGVPATVSEKQEFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVRNRRAGYEV 66
+ + A +E+Q+FY LL NL++P +VR+QAEE YENIPG K TFLL A+RN A E
Sbjct: 17 SAMAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEA 76
Query: 67 RQMAAALLRRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLAR 126
RQMAA LLRRLLSS F+EVYP LP+DVQ +K EL++ +++ET +SMRKK+CDI A LAR
Sbjct: 77 RQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELAR 136
Query: 127 NLIDEDGTNHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDIIKRLLD 186
NLIDEDG N WPEGLKFL DS+ S+NV L E ALH+FW+FPGIFG Q++H LD+IKR+L
Sbjct: 137 NLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLV 196
Query: 187 QCIQDQEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDSVLE 246
QC+QDQEHP+IRTLSARA AAF+LANE+N+ALFK FADLLPG LQAVNDSCYQ+DDSVL+
Sbjct: 197 QCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLK 256
Query: 247 SLVEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATPMLKKHT 306
SLVEIADTVPKYL P+LE TLQLSLKLCGD+ L+N+QRQLALEVIVTLSETA ML+KHT
Sbjct: 257 SLVEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHT 316
Query: 307 NIIAQAVPHILAMMVDLQDDEDWVNADEMEEDDFDSNAVAAESALDRLACGLGGKVVLPM 366
NI+AQ +P +LAMMVDL++DEDW NADE+E+DDFDSNAVA ESALDR+ACGLGGK+VLPM
Sbjct: 317 NIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPM 376
Query: 367 TKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAA 426
KEHIMQMLQ+PDWKYRHAGLMALSAIGEGCHQQME IL+E VN VLLFLQDPHPRVR A
Sbjct: 377 IKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYA 436
Query: 427 ACTTLGQMATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSLL 486
AC +GQMATDFAP FQKKFHE VIAALL+TME+QGNQRVQ+HAA+ALI F EDCPKSLL
Sbjct: 437 ACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLL 496
Query: 487 VLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYYDIFMPSL 546
+ Y+D++VK+LHS++V+KLQELI+ GTKL LEQ+VT+IASVADT EEKFVPYYD+FMPSL
Sbjct: 497 IPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSL 556
Query: 547 KHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLKTQSDLNNMEDDD 606
KHIVE AVQKEL+LLRGKTIECIS IGLAVGKEKFMQDAS+VMQLLLKTQ+D N+MEDDD
Sbjct: 557 KHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDD 616
Query: 607 PQTSYMVSAWARMCKILGKDFQQYLPLVIEPLIKTASAKPDVALLDTQDVENMSDDDGWQ 666
PQ SYM+SAWARMCKILGK+FQQYLP+V+ PL+KTAS KP+VALLDTQD+ENMSDDDGW+
Sbjct: 617 PQISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWE 676
Query: 667 FVNLGDQQSFGIKTSGLEAKATACQMLVYYAKELREGFVEYTEQVVKLMVPLLKFYFHDN 726
FVNLGDQQSFGIKT+GLE K+TACQMLV YAKEL+EGFVEYTEQVVKLMVPLLKFYFHD
Sbjct: 677 FVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDG 736
Query: 727 VRVAAAESMPFLLECARIRGPEYLAQMWQFICDPLIKAIGTEPDTDVLSEIMNSFAKSIE 786
VRVAAAESMP LLECAR+RGPEYL QMW F+CD LIKAIGTEPD+DVLSEIM+SFAK IE
Sbjct: 737 VRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIE 796
Query: 787 VMGDGCLNDEHLEELGGILKAKLEGHFKNQELRQVKRQEENYDQQVEMSLQDEDECDVYI 846
VMGDGCLN+EH EELGGILKAKLE HFKNQELRQVKRQ+E+YD+QVE SLQDED+ DVYI
Sbjct: 797 VMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYI 856
Query: 847 LTKVSDILHSLFSTYKEKILPWFEQLLPLIVNLICSSRPWPDRQWGLCIFDDIIEHCSPT 906
LTKVSDILHS+FS+YKEK+LPWFEQLLPLIVNLIC RPWPDRQWGLCIFDD+IEHCSP
Sbjct: 857 LTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPA 916
Query: 907 SFKYVEYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIKCA 966
SFKY EYF PML + DN+PEVRQAAAYGLGVMAQ+GGD+YR C+EA+PLLV+VI+ A
Sbjct: 917 SFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSA 976
Query: 967 NSKTKKNVIATENCISAIGKILKFKPNCVNVDEVLPHWLSWLPLHEDKEEAIQTLSFLCD 1026
+SKTK+NV ATENCISA+GKI+KFKP+CVNV+EVLPHWLSWLPLHEDKEEA+QT ++LCD
Sbjct: 977 DSKTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCD 1036
Query: 1027 LIESNHPVVIGPNNSNLPKIISIIAEGKINETINYEDPCAKRLANVVRQVQTSEDLWLEC 1086
LIESNHP+V+GPNN+NLPKI SIIAEG+++E I +EDPCAKRLANVVRQVQTS LW EC
Sbjct: 1037 LIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTEC 1096
Query: 1087 VSQLDDEQQEALQELLNFA 1105
++QL EQQ A+QELLN A
Sbjct: 1097 IAQLSPEQQAAIQELLNSA 1115
>gi|62460637 importin 4 [Homo sapiens]
Length = 1081
Score = 151 bits (381), Expect = 4e-36
Identities = 240/1083 (22%), Positives = 441/1083 (40%), Gaps = 102/1083 (9%)
Query: 21 QLLKNLINPSC-MVRRQAEEIYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLLS 79
QLL+ L+ P +RR E++ + L D + + A ++RQ AA L RR L+
Sbjct: 8 QLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASA-ADPQIRQFAAVLTRRRLN 66
Query: 80 SGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDEDGTNHWPE 139
+ + L A+ + +K ++ A++ ET + L + A + R ++G WP+
Sbjct: 67 TRWRR----LAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFR----KEGLEAWPQ 118
Query: 140 GLKFLIDSIYSKNVVLWEVALH----VFWHFPGIFGTQERHDLDIIKRLLDQCIQDQEHP 195
L+ L S +S + E+ L V P F R L RLL++ + + P
Sbjct: 119 LLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELL----RLLNETLGEVGSP 174
Query: 196 AIRTLSARAAAAFV-LANENNIALFKDFADLLPGILQAVNDSCYQDDDSV---LESLVEI 251
+ S R + ++ L + L+P ++ A+ D+ LE+L E+
Sbjct: 175 GLLFYSLRTLTTMAPYLSTEDVPLARM---LVPKLIMAMQTLIPIDEAKACEALEALDEL 231
Query: 252 ADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATPMLKKHTNIIAQ 311
++ + PYL + L L++ + L N R L + L + + L K N +
Sbjct: 232 LESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLK--NRLLP 289
Query: 312 AVPHILAMMVDLQDDEDWVNADEM--EEDDFDSNAVA------AESALDRLACGLGGKVV 363
+ H L +V + ++ ++ EE++ + + A +D LA L + +
Sbjct: 290 PLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKL 349
Query: 364 LPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQM-ESILDETVNSVLLFLQDPHPR 422
P + + L+S R AGL+ L+ + +G + + +L + V L+DP
Sbjct: 350 CPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQV 409
Query: 423 VRAAACTTLGQMATDFAPNFQKKFHETV--IAALLRTMENQGNQRVQSHAASALIIFIED 480
VR AA LGQ + + P+ E + + A L+++ G+ + A AL F+E+
Sbjct: 410 VRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVP-LGHTHHLAKACYALENFVEN 468
Query: 481 C-PKSLLVLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYY 539
PK + L ++ LQ L + A E V+ + ++A + +PY+
Sbjct: 469 LGPK---------VQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYF 519
Query: 540 DIFMPSLKHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLKTQSDL 599
M L+ + L +++L+ ++ +++E + + AVG E A QL L L
Sbjct: 520 PAIMEHLREFL-LTGREDLQPVQIQSLETLGVLARAVG-EPMRPLAEECCQLGL----GL 573
Query: 600 NNMEDDDPQTSYMVSAWARMCKILGKDFQQYLPLVIE-PLIKTASAKPDVALLDTQDVEN 658
+ DD S +A + ++G+ +L + L+ S + V D
Sbjct: 574 CDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFL 633
Query: 659 MSDD--DGWQFVNLGDQQ----------SFGIKTSGLEAKATACQMLVYYAKELREGFVE 706
+ DD DG + L D+ + ++ + + K C + + F+
Sbjct: 634 LFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFLP 693
Query: 707 YTEQVVKLMVPLLKFYFHDNVRVAAAESMPFLL--------ECARIRGPEYLAQMWQFIC 758
Y E V + + LL+ H NVR AA E++ C L +
Sbjct: 694 YMESVFEEVFKLLECP-HLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAALARVV 752
Query: 759 DPLIKAIGTEPDTDVLSEIMNSFAKSIEVMGDGCLNDE-HLEELGGILKAKLEGHFKNQE 817
++A+ E + V+ ++ + + G L L EL G+LKA L
Sbjct: 753 PSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVL-------- 804
Query: 818 LRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSDILHSLFSTYK-EKILPWFEQLLPLI 876
Q K ++ D++ E D+ E D +L + + +L + + P+F LPL+
Sbjct: 805 --QRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFAGFLPLL 862
Query: 877 VNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYG 936
V ++ + + + I+ S ++V +L ++ +PEVR A +G
Sbjct: 863 VCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFG 922
Query: 937 LGVMAQFGG----DDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAIGKILKFKP 992
+GV+A+ GG + + L PLL + +++ +N A+ ++L P
Sbjct: 923 MGVLAEHGGHPAQEHFPKLLGLLFPLLAR---------ERHDRVRDNICGALARLLMASP 973
Query: 993 NCVNVDEVLPHWLSWLPLHEDKEEAIQTLSFLCDLIESNHPVVIGPNNSNLPKIISIIAE 1052
+VL L LPL ED EE + L +S+ VI L I+A+
Sbjct: 974 TRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLRICSLILAD 1033
Query: 1053 GKI 1055
KI
Sbjct: 1034 NKI 1036
>gi|23510381 transportin 1 isoform 2 [Homo sapiens]
Length = 890
Score = 69.3 bits (168), Expect = 2e-11
Identities = 137/679 (20%), Positives = 269/679 (39%), Gaps = 127/679 (18%)
Query: 17 QEFYQLLKNLINPSCMVRRQAEEIYENIPGLCK-TTFLLDAVRNRRAGYE-VRQMAAALL 74
Q+ QLLK +P ++R ++ E + +L+ + ++ E R ++ +L
Sbjct: 13 QQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLIL 72
Query: 75 RRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDEDGT 134
+ + + F+ N P V +K E + + ++ +R + +L + +
Sbjct: 73 KNNVKAHFQ----NFPNGVTDFIKSECLNNIG-DSSPLIRATV----GILITTIASKGEL 123
Query: 135 NHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDIIKR----LLDQCIQ 190
+WP+ L L + S++ E A + E D D++ R ++ + +Q
Sbjct: 124 QNWPDLLPKLCSLLDSEDYNTCEGAFGALQKI--CEDSAEILDSDVLDRPLNIMIPKFLQ 181
Query: 191 DQEH--PAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDSVLESL 248
+H P IR+ + F+++ + L D + + D + +V +L
Sbjct: 182 FFKHSSPKIRSHAVACVNQFIISRTQALMLHID--SFIENLFALAGDEEPEVRKNVCRAL 239
Query: 249 VEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVI---VTLSETATPMLKKH 305
V + + L P++ + ++ L+ R + +ALE +TL+E P+ K
Sbjct: 240 VMLLEVRMDRLLPHMHNIVEYMLQ-----RTQDQDENVALEACEFWLTLAEQ--PICK-- 290
Query: 306 TNIIAQAVPHILAMMVD----------------------------------------LQD 325
+++ + +P ++ ++V+ Q
Sbjct: 291 -DVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQH 349
Query: 326 DEDWVNADEMEEDDFDSNAVAAE--------SALDRLACGLGGKV---VLPMTKEHIMQM 374
DED + ++ ++D+ D + ++ +ALD LA ++ +LP+ KE +
Sbjct: 350 DEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKE----L 405
Query: 375 LQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQM 434
L +W + +G++ L AI EGC Q M L E + ++ L D VR+ C TL +
Sbjct: 406 LFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 465
Query: 435 ATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSL---LVLYVD 491
A + + ++ LL+ + + N+RVQ A SA E+ L L +D
Sbjct: 466 AHWVVSQPPDTYLKPLMTELLKRILD-SNKRVQEAACSAFATLEEEACTELVPYLAYILD 524
Query: 492 SMV----KNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKF--VPYYDIFMPS 545
++V K H L+I L I ++AD++ Y + MP
Sbjct: 525 TLVFAFSKYQHKNLLI----------------LYDAIGTLADSVGHHLNKPEYIQMLMPP 568
Query: 546 LKHIVELAVQKELKLLRGKTIECISHIGLAVGK------EKFMQDASNVMQLLLKTQSDL 599
L + ++ L +EC+S + A+ E Q N++Q L Q+ L
Sbjct: 569 LIQKWNMLKDEDKDLF--PLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTL-AQAML 625
Query: 600 NNMEDDD---PQTSYMVSA 615
NN + D P +M+ A
Sbjct: 626 NNAQPDQYEAPDKDFMIVA 644
>gi|133925811 transportin 1 isoform 1 [Homo sapiens]
Length = 898
Score = 69.3 bits (168), Expect = 2e-11
Identities = 137/679 (20%), Positives = 269/679 (39%), Gaps = 127/679 (18%)
Query: 17 QEFYQLLKNLINPSCMVRRQAEEIYENIPGLCK-TTFLLDAVRNRRAGYE-VRQMAAALL 74
Q+ QLLK +P ++R ++ E + +L+ + ++ E R ++ +L
Sbjct: 21 QQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLIL 80
Query: 75 RRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDEDGT 134
+ + + F+ N P V +K E + + ++ +R + +L + +
Sbjct: 81 KNNVKAHFQ----NFPNGVTDFIKSECLNNIG-DSSPLIRATV----GILITTIASKGEL 131
Query: 135 NHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDIIKR----LLDQCIQ 190
+WP+ L L + S++ E A + E D D++ R ++ + +Q
Sbjct: 132 QNWPDLLPKLCSLLDSEDYNTCEGAFGALQKI--CEDSAEILDSDVLDRPLNIMIPKFLQ 189
Query: 191 DQEH--PAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDSVLESL 248
+H P IR+ + F+++ + L D + + D + +V +L
Sbjct: 190 FFKHSSPKIRSHAVACVNQFIISRTQALMLHID--SFIENLFALAGDEEPEVRKNVCRAL 247
Query: 249 VEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVI---VTLSETATPMLKKH 305
V + + L P++ + ++ L+ R + +ALE +TL+E P+ K
Sbjct: 248 VMLLEVRMDRLLPHMHNIVEYMLQ-----RTQDQDENVALEACEFWLTLAEQ--PICK-- 298
Query: 306 TNIIAQAVPHILAMMVD----------------------------------------LQD 325
+++ + +P ++ ++V+ Q
Sbjct: 299 -DVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQH 357
Query: 326 DEDWVNADEMEEDDFDSNAVAAE--------SALDRLACGLGGKV---VLPMTKEHIMQM 374
DED + ++ ++D+ D + ++ +ALD LA ++ +LP+ KE +
Sbjct: 358 DEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKE----L 413
Query: 375 LQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQM 434
L +W + +G++ L AI EGC Q M L E + ++ L D VR+ C TL +
Sbjct: 414 LFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 473
Query: 435 ATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSL---LVLYVD 491
A + + ++ LL+ + + N+RVQ A SA E+ L L +D
Sbjct: 474 AHWVVSQPPDTYLKPLMTELLKRILD-SNKRVQEAACSAFATLEEEACTELVPYLAYILD 532
Query: 492 SMV----KNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKF--VPYYDIFMPS 545
++V K H L+I L I ++AD++ Y + MP
Sbjct: 533 TLVFAFSKYQHKNLLI----------------LYDAIGTLADSVGHHLNKPEYIQMLMPP 576
Query: 546 LKHIVELAVQKELKLLRGKTIECISHIGLAVGK------EKFMQDASNVMQLLLKTQSDL 599
L + ++ L +EC+S + A+ E Q N++Q L Q+ L
Sbjct: 577 LIQKWNMLKDEDKDLF--PLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTL-AQAML 633
Query: 600 NNMEDDD---PQTSYMVSA 615
NN + D P +M+ A
Sbjct: 634 NNAQPDQYEAPDKDFMIVA 652
>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b)
isoform 1 [Homo sapiens]
Length = 897
Score = 65.5 bits (158), Expect = 3e-10
Identities = 76/281 (27%), Positives = 124/281 (44%), Gaps = 49/281 (17%)
Query: 321 VDLQDDEDWVNADEMEEDDFDSNAVA-------AESALDRLACGLGGKVVLPMTKEHIMQ 373
V L + + + E EDD D +A++ + +ALD LA + + +LP +
Sbjct: 343 VTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLA-NVFREELLPHLLPLLKG 401
Query: 374 MLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQ 433
+L P+W + +G++ L AI EGC Q M L E + ++ L D VR+ AC TL +
Sbjct: 402 LLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSR 461
Query: 434 MATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDC------------ 481
A + ++ LL+ + + GN+RVQ A SA E+
Sbjct: 462 YAHWVVSQPPDMHLKPLMTELLKRILD-GNKRVQEAACSAFATLEEEACTELVPYLSYIL 520
Query: 482 -----------PKSLLVLY------VDSMVKNLHSVLVIK--LQELIRNGTKLALEQ--- 519
K+LL+LY DS+ +L+ I+ + LI+ +L E
Sbjct: 521 DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDL 580
Query: 520 --LVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQKEL 558
L+ ++SVA ++ F+PY + P + V L VQK L
Sbjct: 581 FPLLECLSSVATALQSGFLPYCE---PVYQRCVTL-VQKTL 617
Score = 32.7 bits (73), Expect = 1.9
Identities = 39/189 (20%), Positives = 74/189 (39%), Gaps = 23/189 (12%)
Query: 343 NAVAAESALDRLACGL--------GGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIG 394
N + S+L R G+ G + P + +L S D+ AL I
Sbjct: 95 NNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKIC 154
Query: 395 EGCHQQMESI-----LDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHET 449
E + ++S L+ + L F + P++R+ A + Q D A +T
Sbjct: 155 EDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNI-DT 213
Query: 450 VIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSLLVLYVDSMVKNLHSVLVIKLQELI 509
I L + + V+ + AL++ +E + +D ++ ++HS++ LQ
Sbjct: 214 FIEHLF-ALAVDDDPEVRKNVCRALVMLLE--------VRIDRLIPHMHSIIQYMLQRTQ 264
Query: 510 RNGTKLALE 518
+ +ALE
Sbjct: 265 DHDENVALE 273
>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b)
isoform 3 [Homo sapiens]
Length = 887
Score = 65.5 bits (158), Expect = 3e-10
Identities = 76/281 (27%), Positives = 124/281 (44%), Gaps = 49/281 (17%)
Query: 321 VDLQDDEDWVNADEMEEDDFDSNAVA-------AESALDRLACGLGGKVVLPMTKEHIMQ 373
V L + + + E EDD D +A++ + +ALD LA + + +LP +
Sbjct: 343 VTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLA-NVFREELLPHLLPLLKG 401
Query: 374 MLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQ 433
+L P+W + +G++ L AI EGC Q M L E + ++ L D VR+ AC TL +
Sbjct: 402 LLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSR 461
Query: 434 MATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDC------------ 481
A + ++ LL+ + + GN+RVQ A SA E+
Sbjct: 462 YAHWVVSQPPDMHLKPLMTELLKRILD-GNKRVQEAACSAFATLEEEACTELVPYLSYIL 520
Query: 482 -----------PKSLLVLY------VDSMVKNLHSVLVIK--LQELIRNGTKLALEQ--- 519
K+LL+LY DS+ +L+ I+ + LI+ +L E
Sbjct: 521 DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDL 580
Query: 520 --LVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQKEL 558
L+ ++SVA ++ F+PY + P + V L VQK L
Sbjct: 581 FPLLECLSSVATALQSGFLPYCE---PVYQRCVTL-VQKTL 617
Score = 32.7 bits (73), Expect = 1.9
Identities = 39/189 (20%), Positives = 74/189 (39%), Gaps = 23/189 (12%)
Query: 343 NAVAAESALDRLACGL--------GGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIG 394
N + S+L R G+ G + P + +L S D+ AL I
Sbjct: 95 NNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKIC 154
Query: 395 EGCHQQMESI-----LDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHET 449
E + ++S L+ + L F + P++R+ A + Q D A +T
Sbjct: 155 EDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNI-DT 213
Query: 450 VIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSLLVLYVDSMVKNLHSVLVIKLQELI 509
I L + + V+ + AL++ +E + +D ++ ++HS++ LQ
Sbjct: 214 FIEHLF-ALAVDDDPEVRKNVCRALVMLLE--------VRIDRLIPHMHSIIQYMLQRTQ 264
Query: 510 RNGTKLALE 518
+ +ALE
Sbjct: 265 DHDENVALE 273
>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform
2 [Homo sapiens]
Length = 887
Score = 65.5 bits (158), Expect = 3e-10
Identities = 76/281 (27%), Positives = 124/281 (44%), Gaps = 49/281 (17%)
Query: 321 VDLQDDEDWVNADEMEEDDFDSNAVA-------AESALDRLACGLGGKVVLPMTKEHIMQ 373
V L + + + E EDD D +A++ + +ALD LA + + +LP +
Sbjct: 343 VTLPHEAERPDGSEDAEDDDDDDALSDWNLRKCSAAALDVLA-NVFREELLPHLLPLLKG 401
Query: 374 MLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQ 433
+L P+W + +G++ L AI EGC Q M L E + ++ L D VR+ AC TL +
Sbjct: 402 LLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSR 461
Query: 434 MATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDC------------ 481
A + ++ LL+ + + GN+RVQ A SA E+
Sbjct: 462 YAHWVVSQPPDMHLKPLMTELLKRILD-GNKRVQEAACSAFATLEEEACTELVPYLSYIL 520
Query: 482 -----------PKSLLVLY------VDSMVKNLHSVLVIK--LQELIRNGTKLALEQ--- 519
K+LL+LY DS+ +L+ I+ + LI+ +L E
Sbjct: 521 DTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDL 580
Query: 520 --LVTTIASVADTIEEKFVPYYDIFMPSLKHIVELAVQKEL 558
L+ ++SVA ++ F+PY + P + V L VQK L
Sbjct: 581 FPLLECLSSVATALQSGFLPYCE---PVYQRCVTL-VQKTL 617
Score = 32.7 bits (73), Expect = 1.9
Identities = 39/189 (20%), Positives = 74/189 (39%), Gaps = 23/189 (12%)
Query: 343 NAVAAESALDRLACGL--------GGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIG 394
N + S+L R G+ G + P + +L S D+ AL I
Sbjct: 95 NNIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKIC 154
Query: 395 EGCHQQMESI-----LDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHET 449
E + ++S L+ + L F + P++R+ A + Q D A +T
Sbjct: 155 EDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQFIMDRAQALMDNI-DT 213
Query: 450 VIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSLLVLYVDSMVKNLHSVLVIKLQELI 509
I L + + V+ + AL++ +E + +D ++ ++HS++ LQ
Sbjct: 214 FIEHLF-ALAVDDDPEVRKNVCRALVMLLE--------VRIDRLIPHMHSIIQYMLQRTQ 264
Query: 510 RNGTKLALE 518
+ +ALE
Sbjct: 265 DHDENVALE 273
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 57.0 bits (136), Expect = 1e-07
Identities = 138/683 (20%), Positives = 267/683 (39%), Gaps = 106/683 (15%)
Query: 18 EFYQLLKNLINPSCMVRRQAEEIYENIPGLCKTTFLLDAVR--NRRAGYEVRQMAAAL-L 74
E +L+ ++P + A++ E TFL++ R +V ++AA L +
Sbjct: 2 ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQI 61
Query: 75 RRLLSSG-------FEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARN 127
+ L+S +++ + + A+ +R+VK ++ + ET+ C +A
Sbjct: 62 KNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQC-----VAGI 116
Query: 128 LIDEDGTNHWPEGLKFLIDSIYSKNVV--LWEVALHVFWHFPGIFGTQERHDLDIIKRLL 185
E N WPE + L+ ++ + N + E L + ++ D +L
Sbjct: 117 ACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKS--NEIL 174
Query: 186 DQCIQD--QEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDS 243
IQ +E P+ + A A + + E A F D I+Q V ++ D
Sbjct: 175 TAIIQGMRKEEPS-NNVKLAATNALLNSLEFTKANF-DKESERHFIMQVVCEATQCPDTR 232
Query: 244 V----LESLVEIADTVPKYLGPYLEDTLQL-----------SLKLCGDSRLSNL---QRQ 285
V L++LV+I +Y+ Y+ L + L G SN+ +
Sbjct: 233 VRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMD 292
Query: 286 LALEVIVTLSETATP--MLKKHTNIIAQAVPHILAMMVDLQDDEDWVNADEMEEDDFDSN 343
LA+E + P K + Q + IL + QD+ D ++DD++
Sbjct: 293 LAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDEND-------DDDDWNPC 345
Query: 344 AVAAESALDRLACGLGGKV--VLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCH-QQ 400
A + C V VLP KEHI ++PDW+YR A +MA I EG Q
Sbjct: 346 KAAGVCLMLLATCCEDDIVPHVLPFIKEHI----KNPDWRYRDAAVMAFGCILEGPEPSQ 401
Query: 401 MESILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMEN 460
++ ++ + + +++ ++DP VR A T+G++ + P + ++ +A LL+ +
Sbjct: 402 LKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRIC-ELLP--EAAINDVYLAPLLQCLIE 458
Query: 461 --QGNQRVQSHAASALIIFIED-----------------CPKSLLVLYVDSMVK------ 495
RV S+ A E C S L V +++
Sbjct: 459 GLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPD 518
Query: 496 ----NLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYYDIFMPSLKHIVE 551
NL S L E+++N K + T + + +++ + HI
Sbjct: 519 GHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQ--------VLQMESHIQS 570
Query: 552 LAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLK---TQSDLNNMEDDDPQ 608
+ + + L+ + ++ V + +Q + VM LL+ + + +++D
Sbjct: 571 TSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQED--- 627
Query: 609 TSYMVSAWARMCKILGKDFQQYL 631
+ A + + ++LG +F +Y+
Sbjct: 628 ---ALMAVSTLVEVLGGEFLKYM 647
>gi|145587088 hypothetical protein LOC165186 [Homo sapiens]
Length = 1019
Score = 35.0 bits (79), Expect = 0.39
Identities = 46/203 (22%), Positives = 89/203 (43%), Gaps = 32/203 (15%)
Query: 348 ESALDRLACGLGGKVVLPMTKEHI-----MQMLQSPDWKYRHAGLMALSAIGEGCHQQME 402
E +D AC K + P + + +Q L S DW+ + GL+++ + CH +
Sbjct: 471 EEEMDLRAC----KELRPFSNPELGLRDALQCLNSSDWQMKEKGLVSIQRLA-ACHSE-- 523
Query: 403 SILDETVNSVLLFLQDPHPRVRA----AACTTLGQMATDFAPNFQKKFHETVIAALLRTM 458
+L ++ V L + +R+ A +TLG + N ++ E + LL+ M
Sbjct: 524 -VLTGKLHDVCLVVTGEVTNLRSKVSHLAISTLGDLFQALKKNMDQEAEE-IARCLLQKM 581
Query: 459 ENQGNQRVQSHAASALIIFIED--CPKSLLVLYVDSM-----------VKNLHSVLVIKL 505
+ N+ +Q A +L +E+ +SL+VL + ++L +VL
Sbjct: 582 ADT-NEFIQRAAGQSLRAMVENVTLARSLVVLTSAGVYHRNPLIRKYAAEHLSAVLEQIG 640
Query: 506 QELIRNGTKLALEQLVTTIASVA 528
E + +GT+ + + LV + +A
Sbjct: 641 AEKLLSGTRDSTDMLVHNLVRLA 663
>gi|109715835 HEAT repeat containing 6 [Homo sapiens]
Length = 1181
Score = 34.7 bits (78), Expect = 0.51
Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 9/87 (10%)
Query: 397 CHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQMATDFA-------PNFQKKFHET 449
C +Q + + N++L+ L+D VRA A +LG + P+FQ++F
Sbjct: 846 CLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGL 905
Query: 450 VIAALLRTM--ENQGNQRVQSHAASAL 474
++ +LR+ ++ +V+S+A AL
Sbjct: 906 LLLKMLRSAIEASKDKDKVKSNAVRAL 932
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 33.5 bits (75), Expect = 1.1
Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 2/125 (1%)
Query: 344 AVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMES 403
A +A S + + + L VV H+ QM+ +PD K +H L ALS + + E
Sbjct: 187 AASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEM 246
Query: 404 ILD-ETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMEN-Q 461
+++ E VL L+D V+ A T + ++A Q + +AA++ + + +
Sbjct: 247 VVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCK 306
Query: 462 GNQRV 466
GN R+
Sbjct: 307 GNTRL 311
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 33.5 bits (75), Expect = 1.1
Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 2/125 (1%)
Query: 344 AVAAESALDRLACGLGGKVVLPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMES 403
A +A S + + + L VV H+ QM+ +PD K +H L ALS + + E
Sbjct: 187 AASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEM 246
Query: 404 ILD-ETVNSVLLFLQDPHPRVRAAACTTLGQMATDFAPNFQKKFHETVIAALLRTMEN-Q 461
+++ E VL L+D V+ A T + ++A Q + +AA++ + + +
Sbjct: 247 VVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCK 306
Query: 462 GNQRV 466
GN R+
Sbjct: 307 GNTRL 311
>gi|25092658 hypothetical protein LOC221927 [Homo sapiens]
Length = 821
Score = 32.0 bits (71), Expect = 3.3
Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 4/70 (5%)
Query: 371 IMQMLQSPDWKYRHAGLMALSAIGEGCHQQMES----ILDETVNSVLLFLQDPHPRVRAA 426
+ + L P W+ R + L L+ + Q + + E L LQDP VRA+
Sbjct: 505 LQKRLCHPCWEVRDSALEFLTQLSRHWGGQADFRCALLASEVPQLALQLLQDPESYVRAS 564
Query: 427 ACTTLGQMAT 436
A T +GQ+++
Sbjct: 565 AVTAMGQLSS 574
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 31.6 bits (70), Expect = 4.3
Identities = 32/124 (25%), Positives = 52/124 (41%), Gaps = 22/124 (17%)
Query: 29 PSCMVRRQAEEIYENIPGLCKTTFLLDAVRNRRAGYEVRQMA--AALLRRLLSSGFEEVY 86
P+ + R +++YEN+ GL K + + E M L R L + +E
Sbjct: 935 PTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI 994
Query: 87 PNLPADVQRDVKI----------ELILAVKLETHASM-------RKKL---CDIFAVLAR 126
P LPA R++++ ELI +KL M +K++ AV A+
Sbjct: 995 PLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAK 1054
Query: 127 NLID 130
NL+D
Sbjct: 1055 NLLD 1058
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 31.6 bits (70), Expect = 4.3
Identities = 32/124 (25%), Positives = 52/124 (41%), Gaps = 22/124 (17%)
Query: 29 PSCMVRRQAEEIYENIPGLCKTTFLLDAVRNRRAGYEVRQMA--AALLRRLLSSGFEEVY 86
P+ + R +++YEN+ GL K + + E M L R L + +E
Sbjct: 913 PTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETI 972
Query: 87 PNLPADVQRDVKI----------ELILAVKLETHASM-------RKKL---CDIFAVLAR 126
P LPA R++++ ELI +KL M +K++ AV A+
Sbjct: 973 PLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAK 1032
Query: 127 NLID 130
NL+D
Sbjct: 1033 NLLD 1036
>gi|27477070 BTAF1 RNA polymerase II, B-TFIID transcription
factor-associated, 170kDa [Homo sapiens]
Length = 1849
Score = 31.6 bits (70), Expect = 4.3
Identities = 16/65 (24%), Positives = 32/65 (49%)
Query: 367 TKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAA 426
T + ++++L W+ RH GL+ + + ++L + + ++ LQD VRA
Sbjct: 390 TVDVLLKLLTQEQWEVRHGGLLGIKYALAVRQDVINTLLPKVLTRIIEGLQDLDDDVRAV 449
Query: 427 ACTTL 431
A +L
Sbjct: 450 AAASL 454
>gi|166197671 adaptor-related protein complex 4, beta 1 subunit [Homo
sapiens]
Length = 739
Score = 31.2 bits (69), Expect = 5.7
Identities = 37/146 (25%), Positives = 56/146 (38%), Gaps = 33/146 (22%)
Query: 912 EYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDY--RSLCSEAVPLLVKVIKCANSK 969
EY + P+L +RD VR+ A G M GD +L +E LL
Sbjct: 119 EYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLL---------- 168
Query: 970 TKKNVIATENCISAIGKILKFKPNCV-------------------NVDEVLPHWLSWLPL 1010
++ I NC+ ++ +ILK + V EVL L + P
Sbjct: 169 RDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPR 228
Query: 1011 HEDKEEAIQTLSFLCDLIESNHPVVI 1036
E EE L+ L ++S+ P V+
Sbjct: 229 SE--EELFDILNLLDSFLKSSSPGVV 252
>gi|109240544 zinc finger protein 596 [Homo sapiens]
Length = 504
Score = 30.8 bits (68), Expect = 7.4
Identities = 26/114 (22%), Positives = 54/114 (47%), Gaps = 15/114 (13%)
Query: 526 SVADTIEEKFVPYYDIFMPSLKHIVELAVQ--KELKLLRGKTIECIS--HIGLAVGKEKF 581
++ DT + K + D+ + ++ H+V + Q K + L + + +E +S I L G+E
Sbjct: 22 ALLDTSQRKL--FQDVMLENISHLVSIGKQLCKSVVLSQLEQVEKLSTQRISLLQGREVG 79
Query: 582 M--QDASNVMQLLLKTQSDLNNMEDDDPQTSYMVSAWARMCKILGKDFQQYLPL 633
+ Q+ + + K S ++ M + ++ C LG+DF Q++ L
Sbjct: 80 IKHQEIPFIQHIYQKGTSTISTMRSHTQEDPFL-------CNDLGEDFTQHIAL 126
>gi|109240542 zinc finger protein 596 [Homo sapiens]
Length = 504
Score = 30.8 bits (68), Expect = 7.4
Identities = 26/114 (22%), Positives = 54/114 (47%), Gaps = 15/114 (13%)
Query: 526 SVADTIEEKFVPYYDIFMPSLKHIVELAVQ--KELKLLRGKTIECIS--HIGLAVGKEKF 581
++ DT + K + D+ + ++ H+V + Q K + L + + +E +S I L G+E
Sbjct: 22 ALLDTSQRKL--FQDVMLENISHLVSIGKQLCKSVVLSQLEQVEKLSTQRISLLQGREVG 79
Query: 582 M--QDASNVMQLLLKTQSDLNNMEDDDPQTSYMVSAWARMCKILGKDFQQYLPL 633
+ Q+ + + K S ++ M + ++ C LG+DF Q++ L
Sbjct: 80 IKHQEIPFIQHIYQKGTSTISTMRSHTQEDPFL-------CNDLGEDFTQHIAL 126
>gi|109240540 zinc finger protein 596 [Homo sapiens]
Length = 504
Score = 30.8 bits (68), Expect = 7.4
Identities = 26/114 (22%), Positives = 54/114 (47%), Gaps = 15/114 (13%)
Query: 526 SVADTIEEKFVPYYDIFMPSLKHIVELAVQ--KELKLLRGKTIECIS--HIGLAVGKEKF 581
++ DT + K + D+ + ++ H+V + Q K + L + + +E +S I L G+E
Sbjct: 22 ALLDTSQRKL--FQDVMLENISHLVSIGKQLCKSVVLSQLEQVEKLSTQRISLLQGREVG 79
Query: 582 M--QDASNVMQLLLKTQSDLNNMEDDDPQTSYMVSAWARMCKILGKDFQQYLPL 633
+ Q+ + + K S ++ M + ++ C LG+DF Q++ L
Sbjct: 80 IKHQEIPFIQHIYQKGTSTISTMRSHTQEDPFL-------CNDLGEDFTQHIAL 126
>gi|73695475 protein BAP28 [Homo sapiens]
Length = 2144
Score = 30.4 bits (67), Expect = 9.7
Identities = 15/49 (30%), Positives = 31/49 (63%)
Query: 916 WPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDYRSLCSEAVPLLVKVIK 964
+ +LL RD++P+VR AA + +A+ ++Y L E++P L ++++
Sbjct: 2067 YQILLKTRDSSPKVRFAALITVLALAEKLKENYIVLLPESIPFLAELME 2115
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,808,272
Number of Sequences: 37866
Number of extensions: 1647641
Number of successful extensions: 4834
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 4772
Number of HSP's gapped (non-prelim): 54
length of query: 1105
length of database: 18,247,518
effective HSP length: 113
effective length of query: 992
effective length of database: 13,968,660
effective search space: 13856910720
effective search space used: 13856910720
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.