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Search of human proteins with 4507531
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507531 toll-like receptor 3 [Homo sapiens]
(904 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507531 toll-like receptor 3 [Homo sapiens] 1825 0.0
gi|20302168 toll-like receptor 8 [Homo sapiens] 199 1e-50
gi|7706093 toll-like receptor 7 [Homo sapiens] 196 6e-50
gi|16751843 toll-like receptor 5 [Homo sapiens] 183 5e-46
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 165 2e-40
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 163 6e-40
gi|167555127 CD180 molecule [Homo sapiens] 145 1e-34
gi|225579152 insulin-like growth factor binding protein, acid la... 144 4e-34
gi|4826772 insulin-like growth factor binding protein, acid labi... 144 4e-34
gi|20143971 toll-like receptor 6 [Homo sapiens] 140 4e-33
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 137 6e-32
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 137 6e-32
gi|19718734 toll-like receptor 2 [Homo sapiens] 132 1e-30
gi|11321571 slit homolog 3 [Homo sapiens] 130 6e-30
gi|45505137 podocan [Homo sapiens] 123 9e-28
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 121 3e-27
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 121 3e-27
gi|41350337 toll-like receptor 1 [Homo sapiens] 118 3e-26
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 118 3e-26
gi|4759146 slit homolog 2 [Homo sapiens] 116 1e-25
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 114 3e-25
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 112 1e-24
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 109 1e-23
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 108 3e-23
gi|238908508 leucine-rich repeat and death domain-containing pro... 107 7e-23
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 105 2e-22
gi|198041768 synleurin [Homo sapiens] 101 4e-21
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 101 4e-21
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 100 6e-21
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 100 1e-20
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 1825 bits (4726), Expect = 0.0
Identities = 904/904 (100%), Positives = 904/904 (100%)
Query: 1 MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTH 60
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTH
Sbjct: 1 MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTH 60
Query: 61 NQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFA 120
NQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFA
Sbjct: 61 NQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFA 120
Query: 121 FCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSN 180
FCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSN
Sbjct: 121 FCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSN 180
Query: 181 NKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEK 240
NKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEK
Sbjct: 181 NKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEK 240
Query: 241 LCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL 300
LCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL
Sbjct: 241 LCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL 300
Query: 301 EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHL 360
EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHL
Sbjct: 301 EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHL 360
Query: 361 NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS 420
NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS
Sbjct: 361 NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS 420
Query: 421 KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP 480
KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP
Sbjct: 421 KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP 480
Query: 481 SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN 540
SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN
Sbjct: 481 SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHN 540
Query: 541 NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT 600
NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT
Sbjct: 541 NLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNT 600
Query: 601 LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNW 660
LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNW
Sbjct: 601 LPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNW 660
Query: 661 INETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV 720
INETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV
Sbjct: 661 INETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIV 720
Query: 721 LLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKE 780
LLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKE
Sbjct: 721 LLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKE 780
Query: 781 DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI 840
DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI
Sbjct: 781 DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI 840
Query: 841 EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK 900
EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK
Sbjct: 841 EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK 900
Query: 901 NSVH 904
NSVH
Sbjct: 901 NSVH 904
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 199 bits (506), Expect = 1e-50
Identities = 261/1012 (25%), Positives = 423/1012 (41%), Gaps = 175/1012 (17%)
Query: 34 VADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISK---- 89
+A+CS+ +L +VP + +T L+L+ N + + +F LT +++ N +
Sbjct: 46 IAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNG 105
Query: 90 ----------LEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIK 139
+ L L+ L L+ N+L Q+ +LTEL L+ N+I I
Sbjct: 106 NPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPS---GLPESLTELSLIQNNIYNIT 162
Query: 140 NNPFVKQKNLITLDLSHNGL-------SSTKLGTQVQLENLQELLLSNNKIQALKSEELD 192
+ NL L L+ N ++ + G L NL+ L LS N + + +
Sbjct: 163 KEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK--- 219
Query: 193 IFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNN--------------VQLGPSLT 238
SSL+KL LS+ QIK S F + L L L+ G S+
Sbjct: 220 --LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASIN 277
Query: 239 EKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNL--NVVGNDSFAW 296
T +R L+LS++ L + F + +L +LDL +N L +
Sbjct: 278 IDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMP--HLKVLDLEFNYLVGEIASGAFLTM 335
Query: 297 LPQLEYFFLEYNNI-----QHL-FSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFS 350
LP+LE L +N I QH+ S + L ++R L+L R + Q + + DDF
Sbjct: 336 LPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHL-RGYVFQEL------REDDFQ 388
Query: 351 -FQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
L L +N+ N I I +F NL+ + LS + S L +T S A+S
Sbjct: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRIS--PLVKDTRQSYANSSS 446
Query: 410 HILNLTKNKISKIESDAFSWLGHL-------------EVLDLGLNEIGQELTGQEWRGLE 456
++ K + + E D S H + LDL LN I + ++ L
Sbjct: 447 FQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFF-IGPNQFENLP 505
Query: 457 NIFEIYLSYNKYLQ-LTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN 515
+I + LS N Q L+ F+ +P ++ L L L + D++ S L +L +LDLS
Sbjct: 506 DIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL-DFDNA-SALTELSDLEVLDLSY 563
Query: 516 NN----IANIND--DMLEGLEKLEILDLQHNNLARLWKHANPGGP--------------- 554
N+ IA + + ++ L++L+L HNN+ L N
Sbjct: 564 NSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDIL 623
Query: 555 --------IYFLKGLSHLHILNLESNGFDEIPVEVFKDL----FELKIID---------- 592
I KGL +L L+L N IP E F +L EL I D
Sbjct: 624 WNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTL 683
Query: 593 -----------------------------------LGLNNLNTLPASVFNNQVSLKSLNL 617
L N ++ LP+ + SLK L+L
Sbjct: 684 LQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDL 743
Query: 618 QKNLITSVEKKVFGP-AFRNLTELDMRFNPFDCTCESIAWFVNWINETHTN--IPELSSH 674
NL+ ++ K L+ L++ NPF+CTC+ I F W++E H N IP L
Sbjct: 744 SSNLLKTINKSALETKTTTKLSMLELHGNPFECTCD-IGDFRRWMDE-HLNVKIPRLVD- 800
Query: 675 YLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYW 734
+C +P G + + ++C + F I + + L H W + F +
Sbjct: 801 VICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIY 860
Query: 735 NVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDK---DWVWEH--FSSMEKEDQSLKFCLE 789
NV + +V G++ + T Q Y AYI + KD DWV + E D+++ CLE
Sbjct: 861 NVCLAKVKGYRSLS--TSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLE 918
Query: 790 ERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIIL 849
ERD++ G+ ++ ++ SI +S+K +FV+T K K + A+Q+ +++N+D II
Sbjct: 919 ERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKT-AFYLALQRLMDENMDVIIF 977
Query: 850 VFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKN 901
+ LE P + + L LR+ + KS IL WP + G F L+ + ++N
Sbjct: 978 ILLE--PVLQHSQYLRLRQRICKS-SILQWPDNPKAEGLFWQTLRNVVLTEN 1026
Score = 84.0 bits (206), Expect = 6e-16
Identities = 142/593 (23%), Positives = 228/593 (38%), Gaps = 133/593 (22%)
Query: 33 EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFN------- 85
E+ S L+ VP LP+++ L L++ Q++ + +F LT LD+ N
Sbjct: 204 ELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNA 263
Query: 86 ----------------------------------TISKLEPELCQKLPMLKVLNLQHN-- 109
++ K+ + +P LKVL+L+ N
Sbjct: 264 PFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL 323
Query: 110 ----------------ELSQLS--------------DKTFAFCTNLTELHLMSNSIQKIK 139
E+ LS + F+ +L LHL Q+++
Sbjct: 324 VGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELR 383
Query: 140 NN---PFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN 196
+ P ++ NL T++L N + NL+ + LS N+I L + +AN
Sbjct: 384 EDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYAN 443
Query: 197 SSLKKLELSSNQIKEF----------------SPGCFHAIGRLFGLFLNNV-QLGPSLTE 239
SS + + + +F P C A G+ L LN++ +GP+ E
Sbjct: 444 SSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQC-AAYGKALDLSLNSIFFIGPNQFE 502
Query: 240 KLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQ 299
L + + NLS +NS S T F + ++ LDL+ N L+ + L
Sbjct: 503 ----NLPDIACLNLS-ANSNAQVLSGTEFSAI--PHVKYLDLTNNRLDFDNASALTELSD 555
Query: 300 LEYFFLEYNNIQHLF-----SHSL---HGLFNVRYLNLKRS--------FTKQSISLASL 343
LE L YN+ H F +H L N++ LNL + + +S SL L
Sbjct: 556 LEVLDLSYNS--HYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVEL 613
Query: 344 PKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVS 403
FS L L N +DN I F GL NL L L S L+ + NE F++
Sbjct: 614 V----FSGNRLDIL--WNDDDNRYISI----FKGLKNLTRLDL--SLNRLKHIPNEAFLN 661
Query: 404 LAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYL 463
L S L L++ N + LE+LDL N++ LT ++ + L
Sbjct: 662 LPAS-LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL-LFLTDSLSDFTSSLRTLLL 719
Query: 464 SYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNN 516
S+N+ L + V SL+ L L LK ++ S + L++L+L N
Sbjct: 720 SHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 772
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 196 bits (499), Expect = 6e-50
Identities = 243/957 (25%), Positives = 411/957 (42%), Gaps = 149/957 (15%)
Query: 41 KLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISK--------LEP 92
+L ++P LP ++ +L+L N + + N T + + L +G N + +E
Sbjct: 138 QLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEK 197
Query: 93 ELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITL 152
+ L LKVL+L+ N ++ + + LTEL+L +N I KI+ + F L L
Sbjct: 198 DAFLNLTKLKVLSLKDNNVTAVPT---VLPSTLTELYLYNNMIAKIQEDDFNNLNQLQIL 254
Query: 153 DLSHN---------GLSSTKLGTQVQ--------LENLQELLLSNNKIQAL--------- 186
DLS N + K + +Q L L+ L L +N +Q +
Sbjct: 255 DLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNIN 314
Query: 187 KSEELDIFANSSLKKLELSSNQIKEFSPGC------FHAIGRLFGLFLNNVQLGPSLTEK 240
K +ELD+ N K E+ + F P F+ +++ +N Q SL
Sbjct: 315 KLQELDLSQNFLAK--EIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSL 372
Query: 241 LCLELANTSIRNLSLSN-SQLSTTSNTTFLGL-----KWTNLTM---------LDLSYNN 285
L + + L N S L N L L K NL+M +DLS N
Sbjct: 373 KILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNK 432
Query: 286 LNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPK 345
++ G+ S ++ + +++ L L RY RS ++ AS
Sbjct: 433 ISPSGDSS-----EVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKE-ASFMS 486
Query: 346 IDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLA 405
+++ +++ + L+ + N I +KS+ F L LK L+LS + S +TL F LA
Sbjct: 487 VNESCYKYGQTLD---LSKNSIFFVKSSDFQHLSFLKCLNLSGNLIS-QTLNGSEFQPLA 542
Query: 406 HSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSY 465
L L+ + N++ + S AF L LEVLD+ N + E I + L++
Sbjct: 543 E--LRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNS--------HYFQSEGITHM-LNF 591
Query: 466 NKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIA------ 519
K L++ LQ+LM+ ++ SS S +L L+ N++
Sbjct: 592 TKNLKV----------LQKLMMND---NDISSSTSRTMESESLRTLEFRGNHLDVLWREG 638
Query: 520 -NINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP 578
N + + L KLE LD+ N+L+ L G P +L L+L NG
Sbjct: 639 DNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMP-------PNLKNLSLAKNGLKSFS 691
Query: 579 VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFR--- 635
+ + L L+ +DL N L T+P + N SLK+L L+ N I S+ K AF+
Sbjct: 692 WKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRY 751
Query: 636 ----------------------NLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSS 673
NL L + N F CTC+++ WFV W+N T IP L++
Sbjct: 752 LDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAV-WFVWWVNHTEVTIPYLAT 810
Query: 674 HYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFY 733
C P + G V D +C+ + F ++ S+ L + ++ H W + +
Sbjct: 811 DVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYI 870
Query: 734 WNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKD---KDWVWEHFSSM--EKEDQSLKFCL 788
++ ++ G++ + + Y A+I++ KD +WV + + ++ CL
Sbjct: 871 YHFCKAKIKGYQRL--ISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCL 928
Query: 789 EERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKV--HHAVQQAIEQNLDS 846
EERD+ G LE + SI+ S+K +FV+T K + FK+ + + Q+ +++ +D
Sbjct: 929 EERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAK---TENFKIAFYLSHQRLMDEKVDV 985
Query: 847 IILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSV 903
IIL+FLE+ ++ + L LR+ + S +L WP + F L+ AL + N V
Sbjct: 986 IILIFLEK--PFQKSKFLQLRKRLCGS-SVLEWPTNPQAHPYFWQCLKNALATDNHV 1039
Score = 77.4 bits (189), Expect = 6e-14
Identities = 121/498 (24%), Positives = 202/498 (40%), Gaps = 82/498 (16%)
Query: 202 LELSSNQIKEFSPGCFHAIGRLFGL-FLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
L L+ N I + SP FH + L + F N C+ + S N+ + Q+
Sbjct: 70 LTLTINHIPDISPASFHRLDHLVEIDFRCN-----------CVPIPLGSKNNMCIKRLQI 118
Query: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHG 320
S F GL T L L L N L + P L+ LE NNI + +L
Sbjct: 119 KPRS---FSGL--TYLKSLYLDGNQLLEIPQ---GLPPSLQLLSLEANNIFSIRKENLTE 170
Query: 321 LFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPG----------- 369
L N+ L L ++ ++ S I+ +F L L+ L+++DN++
Sbjct: 171 LANIEILYLGQNCYYRNPCYVSY-SIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTE 229
Query: 370 ----------IKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHI-------- 411
I+ + F L L+ L LS + +SPL I
Sbjct: 230 LYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDAL 289
Query: 412 -----LNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEW-RGLENIFEIYLSY 465
L L N + + F + L+ LDL N + +E+ ++ L ++ ++ LS+
Sbjct: 290 TELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSF 349
Query: 466 NKYLQLTRNS------FALVPSLQRLMLRRVALKNVDS-SPSPFQPLRNLTILDLSNNNI 518
N LQ+ R S F+ + SL+ L +R K + S + SP L+NL +LDL N I
Sbjct: 350 NFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFI 409
Query: 519 ANINDDMLEGLEKLEILDLQHNNLA--------RLWKHANPGGPIYFLKGLSHLHILNLE 570
N M + ++L+++DL N ++ +A Y + L LH +
Sbjct: 410 KIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYD 469
Query: 571 S-------NGFDEIPVEVFKDLFEL-KIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLI 622
+ + V + ++ + +DL N++ + +S F + LK LNL NLI
Sbjct: 470 KYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLI 529
Query: 623 TSVEKKVFGPAFRNLTEL 640
+ + + G F+ L EL
Sbjct: 530 S---QTLNGSEFQPLAEL 544
Score = 38.9 bits (89), Expect = 0.022
Identities = 45/147 (30%), Positives = 65/147 (44%), Gaps = 11/147 (7%)
Query: 27 KCTVSHEVADCSHLKLTQVPDDLPT---NITVLNLTHNQLRRLPAANFTRYSQLTSLDVG 83
+C + E D SH +LT VP+ L ++ L L +NQ+R L QL LD+
Sbjct: 696 QCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLS 755
Query: 84 FNTISKLE----PELCQKLPMLKVLNLQHNELSQLSDKT-FAFCTNLTELHLMSNSIQKI 138
N I ++ PE L LK+L L HN D F + N TE+ + +
Sbjct: 756 SNKIQMIQKTSFPE--NVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVT 813
Query: 139 KNNPFV-KQKNLITLDLSHNGLSSTKL 164
P K +++I+LDL L T L
Sbjct: 814 CVGPGAHKGQSVISLDLYTCELDLTNL 840
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 183 bits (465), Expect = 5e-46
Identities = 218/869 (25%), Positives = 355/869 (40%), Gaps = 163/869 (18%)
Query: 119 FAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLL 178
+ FC NLT++ + N+ +++ LS N + + + LE LQ L L
Sbjct: 33 YRFC-NLTQVPQVLNTTERLL--------------LSFNYIRTVTASSFPFLEQLQLLEL 77
Query: 179 SNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSL 237
+ +E F N +L+ L+L S++I P F + LF L L L ++
Sbjct: 78 GSQYTPLTIDKEA--FRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV 135
Query: 238 TEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNL-NVVGNDSFAW 296
L + RNL LT LDLS N + ++ + SF
Sbjct: 136 -------LKDGYFRNLKA--------------------LTRLDLSKNQIRSLYLHPSFGK 168
Query: 297 LPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKC 356
L L+ N I + H L L + T SLA+ S W KC
Sbjct: 169 LNSLKSIDFSSNQIFLVCEHELEPL---------QGKTLSFFSLAANSLYSRVSVDWGKC 219
Query: 357 --------LEHLNMEDN----DIPG------IKSNMFTGLINLKYLSLSNSFTSLRTLTN 398
LE L++ N DI G KS F+ ++ + F +++
Sbjct: 220 MNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQ 279
Query: 399 ETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENI 458
TF LA S + L+L+ + + S F L L+VL+L N+I + + + + GL+N+
Sbjct: 280 NTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINK-IADEAFYGLDNL 338
Query: 459 FEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNI 518
+ LSYN +L ++F +P + + L++ + + F L L LDL +N +
Sbjct: 339 QVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKF--LEKLQTLDLRDNAL 396
Query: 519 ANIN------DDMLEG-----LEKLEI----LDLQHNNLARLWKHANPGGPIYFLKGLSH 563
I+ D L G L K+ + + L N L L +YFL + H
Sbjct: 397 TTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENL-------DILYFLLRVPH 449
Query: 564 LHILNLESNGF-----DEIPVE-------------------------VFKDLFELKIIDL 593
L IL L N F D+ P E VF+ L L+++ L
Sbjct: 450 LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYL 509
Query: 594 GLNNLNTLPASVFNNQVSLKSLNLQKNLITSVE---------------KKVFGP---AFR 635
N LN+LP VF++ +L+ L+L N +T + ++ P F
Sbjct: 510 NHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFV 569
Query: 636 NLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSS 695
+L+ LD+ N F C CE ++ F+NW+N T+ I + C P + G + T
Sbjct: 570 SLSVLDITHNKFICECE-LSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEG 628
Query: 696 CKD-----SAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQ 750
C + S F LF + ++ L + I+ + F G+ Y + L FK+ +
Sbjct: 629 CDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICY---KTAQRLVFKDHPQG 685
Query: 751 TE--QFEYAAYIIHAYKDKDWVW----EHFSSMEKEDQSLKFCLEERDFEAGVFELEAIV 804
TE ++Y AY+ + KD WV +H + + C EERDF G + I
Sbjct: 686 TEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQ 745
Query: 805 NSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHAL 864
++I SRKI+ +++ H L+D C +A + + ++I+V + + Y+L
Sbjct: 746 DAIWNSRKIVCLVSRHFLRDGWCLE-AFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQ 804
Query: 865 CLRRGMFKSHCILNWPVQKERIGAFRHKL 893
+ RG + L WP + +G F HKL
Sbjct: 805 SI-RGFVQKQQYLRWPEDLQDVGWFLHKL 832
Score = 114 bits (285), Expect = 4e-25
Identities = 164/635 (25%), Positives = 266/635 (41%), Gaps = 84/635 (13%)
Query: 28 CTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFN-T 86
C+ +A LTQVP L T +L L+ N +R + A++F QL L++G T
Sbjct: 24 CSFDGRIAFYRFCNLTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQLLELGSQYT 82
Query: 87 ISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHL----MSNSIQKIKNNP 142
++ E + LP L++L+L +++ L F +L EL L +S+++ +K+
Sbjct: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV--LKDGY 140
Query: 143 FVKQKNLITLDLSHNGLSSTKLGTQV-QLENLQELLLSNNKIQALKSEELDIFANSSLKK 201
F K L LDLS N + S L +L +L+ + S+N+I + EL+ +L
Sbjct: 141 FRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSF 200
Query: 202 LELSSNQIKEFSP----GCFHAIGRLFGLFLN------------NVQLGPSLTEKLCLEL 245
L++N + C + + L+ N S ++ L L
Sbjct: 201 FSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLIL 260
Query: 246 ANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFL 305
A+ I + TF GL +++ LDLS+ + + + F L L+ L
Sbjct: 261 AH-HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNL 319
Query: 306 EYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQ--SISLASLPK-------------IDDFS 350
YN I + + +GL N++ LNL + + S + LPK I D +
Sbjct: 320 AYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQT 379
Query: 351 FQWLKCLEHLNMEDND------IPGIKSNMFTG--LINLKYLSLSNSFTSLRTLTNET-- 400
F++L+ L+ L++ DN IP I +G L+ L ++L+ + L E
Sbjct: 380 FKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLD 439
Query: 401 --FVSLAHSPLHILNLTKNKISKIESDAF-SWLGHLEVLDLGLNEI----GQELTGQEWR 453
+ L L IL L +N+ S D S LE L LG N + EL +
Sbjct: 440 ILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499
Query: 454 GLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDL 513
GL ++ +YL++N L F+ + +L+ L L L + + P NL ILD+
Sbjct: 500 GLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP----ANLEILDI 555
Query: 514 SNNNIANINDDMLEGLEKLEILDLQHN---------NLARLWKHAN-----PGGPIY--F 557
S N + N D+ L +LD+ HN H N P IY +
Sbjct: 556 SRNQLLAPNPDV---FVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVY 612
Query: 558 LKGLSHLHILNLESNGFDEIPVEVFKDL-FELKII 591
S + + +L + G DE EV K L F L I+
Sbjct: 613 PDSFSGVSLFSLSTEGCDE--EEVLKSLKFSLFIV 645
Score = 76.3 bits (186), Expect = 1e-13
Identities = 81/306 (26%), Positives = 137/306 (44%), Gaps = 33/306 (10%)
Query: 17 FGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQ 76
F L SS +SH + ++ + DL VLNL +N++ ++ F
Sbjct: 282 FAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLK----VLNLAYNKINKIADEAFYGLDN 337
Query: 77 LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQ 136
L L++ +N + +L LP + ++LQ N ++ + D+TF F L L L N++
Sbjct: 338 LQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALT 397
Query: 137 KIKNNP-----FVKQKNLITL----------DLSHNGLSSTK-LGTQVQLENLQELLLSN 180
I P F+ L+TL LS N L + L +++ +LQ L+L+
Sbjct: 398 TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQ 457
Query: 181 NKIQALKSEELDIFANSSLKKLELSSNQIK-----EFSPGCFHAIGRLFGLFLNNVQLGP 235
N+ + ++ N SL++L L N ++ E F + L L+LN+ L
Sbjct: 458 NRFSSCSGDQTP-SENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLN- 515
Query: 236 SLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFA 295
SL + L T++R LSL++++L+ S+ NL +LD+S N L D F
Sbjct: 516 SLPPGVFSHL--TALRGLSLNSNRLTVLSHNDLP----ANLEILDISRNQLLAPNPDVFV 569
Query: 296 WLPQLE 301
L L+
Sbjct: 570 SLSVLD 575
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 165 bits (417), Expect = 2e-40
Identities = 242/1008 (24%), Positives = 399/1008 (39%), Gaps = 168/1008 (16%)
Query: 32 HEVADCSHLKLTQVPDDLPT----NITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTI 87
H + +C+ L L VP N+T L+L+ N++ L ++F L L++ +N
Sbjct: 40 HGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCP 99
Query: 88 S------------KLEPELCQKLPMLKVLNLQHNELS--------------------QLS 115
+EP +P L+ LNL +N + L
Sbjct: 100 PVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLD 159
Query: 116 DKTFAFCTNLTELHLMSNSIQK--------IKNNPFVKQKNLITLDLSHNGLSSTKLGTQ 167
+ A L L + N K + + NL L L +N L+
Sbjct: 160 SASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLP 219
Query: 168 VQLENLQELLLSNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPGCFHAIGRLFGL 226
LE L LLS N+I L E+L AN ++L+ L++ N + C HA
Sbjct: 220 SSLEYL---LLSYNRIVKLAPEDL---ANLTALRVLDVGGNCRR-----CDHAPNPCMEC 268
Query: 227 FLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNL 286
+ QL P L + + L L +S LS + + F GL NL +LDLS N L
Sbjct: 269 PRHFPQLHPDTFSHL------SRLEGLVLKDSSLSWLNASWFRGLG--NLRVLDLSENFL 320
Query: 287 N--VVGNDSFAWLPQLEYFFLEYNNIQHL-FSH-SLHGLFNVRYLNLKRSFTKQSISLAS 342
+ +F L QL L +N + + F+H SL F L + I S
Sbjct: 321 YKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGS--LVALKELDMHGIFFRS 378
Query: 343 LPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTS---------- 392
L + L L+ L ++ N I + +F L+Y+ LS++ S
Sbjct: 379 LDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMG 438
Query: 393 -------------------LRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHL 433
+ T ++E F + L+L++N + ++ + F+ L HL
Sbjct: 439 EADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHL 498
Query: 434 EVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLML----RR 489
+ L L N I Q + G ++ L + + LS+NK +SF +P L+ L L +
Sbjct: 499 QCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQP 558
Query: 490 VALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHA 549
++ V + S LR L L L++NNI + L L LD N L +W
Sbjct: 559 FGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTS-LRALDFSGNALGHMWAEG 617
Query: 550 NPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFE---------------------- 587
+ ++F +GLS L L+L N + + ++L +
Sbjct: 618 DLY--LHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHF 675
Query: 588 ---LKIIDLGLNNLN-----TLPASV-------------------FNNQVSLKSLNLQKN 620
L+++DL N L +LPA F+ L+ LNL N
Sbjct: 676 LPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSAN 735
Query: 621 LITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTP 680
+ +V+ FGP L LD+ NP C C A F++++ E +P L S C +P
Sbjct: 736 ALKTVDHSWFGPLASALQILDVSANPLHCACG--AAFMDFLLEVQAAVPGLPSRVKCGSP 793
Query: 681 PHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHR 740
G + D C D A F ++ + + + + +L H GW + + +++ +
Sbjct: 794 GQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAW 853
Query: 741 V-LGFKEIDRQTEQFEYAAYIIHAYKDK---DWVWEHFSSMEKEDQ---SLKFCLEERDF 793
+ ++ R + Y A+++ DWV+ +E + +L+ CLEERD+
Sbjct: 854 LPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDW 913
Query: 794 EAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLE 853
G E + S+ SRK +FV+ H L R A Q+ +E D ++LV L
Sbjct: 914 LPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLL-RASFLLAQQRLLEDRKDVVVLVILS 972
Query: 854 EIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKN 901
PD + + + LR+ + + +L WP Q +F +L +AL N
Sbjct: 973 --PDGRRSRYVRLRQRLCRQSVLL-WPHQPSGQRSFWAQLGMALTRDN 1017
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 163 bits (413), Expect = 6e-40
Identities = 214/857 (24%), Positives = 358/857 (41%), Gaps = 113/857 (13%)
Query: 37 CSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQ 96
C L ++PD+LP + L+L+ N LR L + +F + +L LD+ I +E Q
Sbjct: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
Query: 97 KLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSH 156
L L L L N + L+ F+ ++L +L + ++ ++N P K L L+++H
Sbjct: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
Query: 157 NGLSSTKLGTQV-QLENLQELLLSNNKIQALKSEELDIFANSSL--KKLELSSNQIKEFS 213
N + S KL L NL+ L LS+NKIQ++ +L + L L+LS N +
Sbjct: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ 219
Query: 214 PGCFHAIGRLFGLFLNNVQLGPSLTEKLCLE-LANTSIRNLSL----SNSQLSTTSNTTF 268
PG F I RL L L N K C++ LA + L L + L +
Sbjct: 220 PGAFKEI-RLHKLTLRN-NFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSAL 277
Query: 269 LGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLE----YNNIQHLFSHSLHGLFNV 324
GL NLT+ + L L+Y+ + +N + ++ S SL +
Sbjct: 278 EGL--CNLTIEEFR--------------LAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIE 321
Query: 325 RYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYL 384
R + +F Q + L + K F LK L+ L N G + L +L++L
Sbjct: 322 RVKDFSYNFGWQHLELVNC-KFGQFPTLKLKSLKRLTFTSN--KGGNAFSEVDLPSLEFL 378
Query: 385 SLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIG 444
LS + S + +++ + L L+L+ N + + S+ F L LE LD + +
Sbjct: 379 DLSRNGLSFKGCCSQS--DFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLK 435
Query: 445 QELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQP 504
Q + L N+ + +S+ F + SL+ L + + + + P F
Sbjct: 436 QMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQE-NFLPDIFTE 494
Query: 505 LRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHL 564
LRNLT LDLS + ++ L L++L++ HNN L
Sbjct: 495 LRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSL------------------- 535
Query: 565 HILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITS 624
D P +K L L+++D LN++ T K LQ + +S
Sbjct: 536 ----------DTFP---YKCLNSLQVLDYSLNHIMT-----------SKKQELQ-HFPSS 570
Query: 625 VEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYH 684
+ AF NLT+ N F CTCE + F+ WI + + E+ C TP
Sbjct: 571 L-------AFLNLTQ-----NDFACTCEHQS-FLQWIKDQRQLLVEV-ERMECATPSDKQ 616
Query: 685 GFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGF 744
G PV + + + +I S+L + + V+ + FY+ H +L
Sbjct: 617 GMPVLSLNITCQMNKT------IIGVSVLSVLVVSVVAVLV----YKFYF----HLMLLA 662
Query: 745 KEIDRQTEQFEYAAYIIHAYKDKDWVW-EHFSSMEKEDQSLKFCLEERDFEAGVFELEAI 803
I + Y A++I++ +D+DWV E ++E+ + CL RDF GV I
Sbjct: 663 GCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANI 722
Query: 804 VN-SIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNH 862
++ +SRK+I V++ H ++ C F+ A + II + L+++ L
Sbjct: 723 IHEGFHKSRKVIVVVSQHFIQSRWC-IFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQ 781
Query: 863 ALCLRRGMFKSHCILNW 879
+ L R + + L W
Sbjct: 782 QVELYR-LLSRNTYLEW 797
>gi|167555127 CD180 molecule [Homo sapiens]
Length = 661
Score = 145 bits (367), Expect = 1e-34
Identities = 179/730 (24%), Positives = 285/730 (39%), Gaps = 89/730 (12%)
Query: 9 YFWGGLLPFGMLCASSTTKCTVSHEVA---DCSHLKLTQVPDDLPTNITVLNLTHNQLRR 65
+FW L G +S + + E +C +L L+++PD LP L + N L
Sbjct: 8 FFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPT 67
Query: 66 LPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNL 125
+ F+R LT LD+ I+ + + Q L L L N L +++ + +L
Sbjct: 68 IHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSL 127
Query: 126 TELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQA 185
L L+ I ++ P +NL +L L N +SS K NL+ L NN I
Sbjct: 128 KHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHY 187
Query: 186 LKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLEL 245
+ E++ + L + N +K G F
Sbjct: 188 ISREDMRSLEQAINLSLNFNGNNVKGIELGAF---------------------------- 219
Query: 246 ANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFL 305
+T F L + L + +N L S WL E
Sbjct: 220 ------------------DSTIFQSLNFGGTPNLSVIFNGLQNSTTQSL-WLGTFEDI-- 258
Query: 306 EYNNIQHLFSHSLHGL--FNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNME 363
+ + + S L GL +V LNL+ I +FQ L+ L++
Sbjct: 259 ---DDEDISSAMLKGLCEMSVESLNLQEH---------RFSDISSTTFQCFTQLQELDLT 306
Query: 364 DNDIPGIKSNMFTGLINLKYLSLS-NSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKI 422
+ G+ S M GL LK L LS N F L ++ F SL H L+I K +
Sbjct: 307 ATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTH--LYIRGNVKKL--HL 361
Query: 423 ESDAFSWLGHLEVLDLGLNEI-GQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
LG+L+ LDL N+I + + + L ++ + LS+N+ L L +F P
Sbjct: 362 GVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQ 421
Query: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
L+ L L L ++++ SPFQ L L +L+L+ + N +L GL L L+L+ N
Sbjct: 422 LELLDLAFTRL-HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGN- 479
Query: 542 LARLWKHANPGG--PIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLN 599
H G L+ + L +L L S G I + F L ++ +DL N+L
Sbjct: 480 ------HFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLT 533
Query: 600 TLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVN 659
++ + LNL N I + ++ P + +++ NP DCTC +I F+
Sbjct: 534 CDSIDSLSHLKGIY-LNLAANSINIISPRLL-PILSQQSTINLSHNPLDCTCSNI-HFLT 590
Query: 660 WINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFI 719
W E + E S C PP G V+L D +FF+I +LL +
Sbjct: 591 WYKENLHKL-EGSEETTCANPPSLRG--VKLSDVKLSCGITAIGIFFLIVFLLLLAILLF 647
Query: 720 VLLIHFEGWR 729
+ + W+
Sbjct: 648 FAVKYLLRWK 657
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 144 bits (363), Expect = 4e-34
Identities = 145/526 (27%), Positives = 236/526 (44%), Gaps = 59/526 (11%)
Query: 37 CSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQ 96
CS LT++PD +P L L N L +P A F S L L++ + LEP+
Sbjct: 98 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 157
Query: 97 KLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSH 156
L L L+L+ N+L L+ TFA L L L +N + ++++ F +L L+L
Sbjct: 158 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 217
Query: 157 NGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPG 215
N L+ L +L+EL+L+ N++ L+ +F+ + L++L+LS N ++
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA---LFSGLAELRELDLSRNALRAIKAN 274
Query: 216 CFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTN 275
F + RL L+L+ RNL ++ + FLGLK
Sbjct: 275 VFVQLPRLQKLYLD---------------------RNL------IAAVAPGAFLGLK--A 305
Query: 276 LTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTK 335
L LDLS+N + + D+F L L L +N I L + L + L L + +
Sbjct: 306 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 365
Query: 336 QSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRT 395
Q + + SF+ L LE L ++ N + +K+ F GL N+ ++LS + LR
Sbjct: 366 Q---------LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN--CLRN 414
Query: 396 LTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGL 455
L + F L LH L+L + + +I F+ L L L L N + + Q GL
Sbjct: 415 LPEQVFRGL--GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL-VGIEEQSLWGL 471
Query: 456 ENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN 515
+ E+ L+ N+ L F + L+ L+L R L + + PL+ LD+S+
Sbjct: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPA--DALGPLQRAFWLDVSH 529
Query: 516 NNIANINDDMLEGLEKLEILDLQHNN----------LARLWKHANP 551
N + + + +L L +L L L++N+ L RLW NP
Sbjct: 530 NRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNP 575
Score = 141 bits (356), Expect = 2e-33
Identities = 154/553 (27%), Positives = 234/553 (42%), Gaps = 79/553 (14%)
Query: 115 SDKTFAFCT--NLTELH-----------LMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 161
+D+ FC+ NLT L L N++ + F +L L+L L S
Sbjct: 91 ADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 150
Query: 162 TKLGTQVQLENLQELLLSNNKIQALKSEELDIFANS-SLKKLELSSNQIKEFSPGCFHAI 220
+ + LENL L L N++++L L FA++ +L L LS+N++ G F +
Sbjct: 151 LEPQALLGLENLCHLHLERNQLRSLA---LGTFAHTPALASLGLSNNRLSRLEDGLFEGL 207
Query: 221 GRLFGLFL--NNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM 278
G L+ L L N++ + P + S+R L L+ ++L+ F GL L
Sbjct: 208 GSLWDLNLGWNSLAVLPDAAFR-----GLGSLRELVLAGNRLAYLQPALFSGL--AELRE 260
Query: 279 LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSI 338
LDLS N L + + F LP+L+ +L+ N I
Sbjct: 261 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA--------------------------- 293
Query: 339 SLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTN 398
+ +F LK L L++ N + G+ + F GL+ L+ L LS++ ++ +L
Sbjct: 294 ------AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN--AIASLRP 345
Query: 399 ETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENI 458
TF L L L L N+I ++ +F LG LEVL L N++ QE+ + GL N+
Sbjct: 346 RTFKDLHF--LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL-QEVKAGAFLGLTNV 402
Query: 459 FEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNI 518
+ LS N L F + L L L L + P F L L L L +N +
Sbjct: 403 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI--RPHTFTGLSGLRRLFLKDNGL 460
Query: 519 ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP 578
I + L GL +L LDL N L L P +GL L L L N E+P
Sbjct: 461 VGIEEQSLWGLAELLELDLTSNQLTHL--------PHRLFQGLGKLEYLLLSRNRLAELP 512
Query: 579 VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLT 638
+ L +D+ N L LP S+ L+ L+L+ N + + F P L
Sbjct: 513 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL-----RTFTPQPPGLE 567
Query: 639 ELDMRFNPFDCTC 651
L + NP+DC C
Sbjct: 568 RLWLEGNPWDCGC 580
Score = 116 bits (290), Expect = 1e-25
Identities = 122/429 (28%), Positives = 184/429 (42%), Gaps = 47/429 (10%)
Query: 248 TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEY 307
+S+ L+L QL + LGL+ NL L L N L + +FA P L L
Sbjct: 136 SSLGFLNLQGGQLGSLEPQALLGLE--NLCHLHLERNQLRSLALGTFAHTPALASLGLSN 193
Query: 308 NNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI 367
N + L GL ++ LNL + SLA LP D +F+ L L L + N +
Sbjct: 194 NRLSRLEDGLFEGLGSLWDLNLGWN------SLAVLP---DAAFRGLGSLRELVLAGNRL 244
Query: 368 PGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAH--------------------- 406
++ +F+GL L+ L LS + +LR + FV L
Sbjct: 245 AYLQPALFSGLAELRELDLSRN--ALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG 302
Query: 407 -SPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSY 465
L L+L+ N+++ + D F L L VL L N I L + ++ L + E+ L +
Sbjct: 303 LKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS-LRPRTFKDLHFLEELQLGH 361
Query: 466 NKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDM 525
N+ QL SF + L+ L L L+ V + F L N+ +++LS N + N+ + +
Sbjct: 362 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGA--FLGLTNVAVMNLSGNCLRNLPEQV 419
Query: 526 LEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDL 585
GL KL L L+ + L R+ H GLS L L L+ NG I + L
Sbjct: 420 FRGLGKLHSLHLEGSCLGRIRPHT--------FTGLSGLRRLFLKDNGLVGIEEQSLWGL 471
Query: 586 FELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFN 645
EL +DL N L LP +F L+ L L +N + + GP R LD+ N
Sbjct: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW-LDVSHN 530
Query: 646 PFDCTCESI 654
+ S+
Sbjct: 531 RLEALPNSL 539
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 144 bits (363), Expect = 4e-34
Identities = 145/526 (27%), Positives = 236/526 (44%), Gaps = 59/526 (11%)
Query: 37 CSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQ 96
CS LT++PD +P L L N L +P A F S L L++ + LEP+
Sbjct: 60 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119
Query: 97 KLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSH 156
L L L+L+ N+L L+ TFA L L L +N + ++++ F +L L+L
Sbjct: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179
Query: 157 NGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPG 215
N L+ L +L+EL+L+ N++ L+ +F+ + L++L+LS N ++
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA---LFSGLAELRELDLSRNALRAIKAN 236
Query: 216 CFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTN 275
F + RL L+L+ RNL ++ + FLGLK
Sbjct: 237 VFVQLPRLQKLYLD---------------------RNL------IAAVAPGAFLGLK--A 267
Query: 276 LTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTK 335
L LDLS+N + + D+F L L L +N I L + L + L L + +
Sbjct: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
Query: 336 QSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRT 395
Q + + SF+ L LE L ++ N + +K+ F GL N+ ++LS + LR
Sbjct: 328 Q---------LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN--CLRN 376
Query: 396 LTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGL 455
L + F L LH L+L + + +I F+ L L L L N + + Q GL
Sbjct: 377 LPEQVFRGL--GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL-VGIEEQSLWGL 433
Query: 456 ENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN 515
+ E+ L+ N+ L F + L+ L+L R L + + PL+ LD+S+
Sbjct: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPA--DALGPLQRAFWLDVSH 491
Query: 516 NNIANINDDMLEGLEKLEILDLQHNN----------LARLWKHANP 551
N + + + +L L +L L L++N+ L RLW NP
Sbjct: 492 NRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNP 537
Score = 141 bits (356), Expect = 2e-33
Identities = 154/553 (27%), Positives = 234/553 (42%), Gaps = 79/553 (14%)
Query: 115 SDKTFAFCT--NLTELH-----------LMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 161
+D+ FC+ NLT L L N++ + F +L L+L L S
Sbjct: 53 ADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 112
Query: 162 TKLGTQVQLENLQELLLSNNKIQALKSEELDIFANS-SLKKLELSSNQIKEFSPGCFHAI 220
+ + LENL L L N++++L L FA++ +L L LS+N++ G F +
Sbjct: 113 LEPQALLGLENLCHLHLERNQLRSLA---LGTFAHTPALASLGLSNNRLSRLEDGLFEGL 169
Query: 221 GRLFGLFL--NNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM 278
G L+ L L N++ + P + S+R L L+ ++L+ F GL L
Sbjct: 170 GSLWDLNLGWNSLAVLPDAAFR-----GLGSLRELVLAGNRLAYLQPALFSGL--AELRE 222
Query: 279 LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSI 338
LDLS N L + + F LP+L+ +L+ N I
Sbjct: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA--------------------------- 255
Query: 339 SLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTN 398
+ +F LK L L++ N + G+ + F GL+ L+ L LS++ ++ +L
Sbjct: 256 ------AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN--AIASLRP 307
Query: 399 ETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENI 458
TF L L L L N+I ++ +F LG LEVL L N++ QE+ + GL N+
Sbjct: 308 RTFKDLHF--LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL-QEVKAGAFLGLTNV 364
Query: 459 FEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNI 518
+ LS N L F + L L L L + P F L L L L +N +
Sbjct: 365 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI--RPHTFTGLSGLRRLFLKDNGL 422
Query: 519 ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP 578
I + L GL +L LDL N L L P +GL L L L N E+P
Sbjct: 423 VGIEEQSLWGLAELLELDLTSNQLTHL--------PHRLFQGLGKLEYLLLSRNRLAELP 474
Query: 579 VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLT 638
+ L +D+ N L LP S+ L+ L+L+ N + + F P L
Sbjct: 475 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL-----RTFTPQPPGLE 529
Query: 639 ELDMRFNPFDCTC 651
L + NP+DC C
Sbjct: 530 RLWLEGNPWDCGC 542
Score = 116 bits (290), Expect = 1e-25
Identities = 122/429 (28%), Positives = 184/429 (42%), Gaps = 47/429 (10%)
Query: 248 TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEY 307
+S+ L+L QL + LGL+ NL L L N L + +FA P L L
Sbjct: 98 SSLGFLNLQGGQLGSLEPQALLGLE--NLCHLHLERNQLRSLALGTFAHTPALASLGLSN 155
Query: 308 NNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI 367
N + L GL ++ LNL + SLA LP D +F+ L L L + N +
Sbjct: 156 NRLSRLEDGLFEGLGSLWDLNLGWN------SLAVLP---DAAFRGLGSLRELVLAGNRL 206
Query: 368 PGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAH--------------------- 406
++ +F+GL L+ L LS + +LR + FV L
Sbjct: 207 AYLQPALFSGLAELRELDLSRN--ALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG 264
Query: 407 -SPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSY 465
L L+L+ N+++ + D F L L VL L N I L + ++ L + E+ L +
Sbjct: 265 LKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS-LRPRTFKDLHFLEELQLGH 323
Query: 466 NKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDM 525
N+ QL SF + L+ L L L+ V + F L N+ +++LS N + N+ + +
Sbjct: 324 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGA--FLGLTNVAVMNLSGNCLRNLPEQV 381
Query: 526 LEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDL 585
GL KL L L+ + L R+ H GLS L L L+ NG I + L
Sbjct: 382 FRGLGKLHSLHLEGSCLGRIRPHT--------FTGLSGLRRLFLKDNGLVGIEEQSLWGL 433
Query: 586 FELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFN 645
EL +DL N L LP +F L+ L L +N + + GP R LD+ N
Sbjct: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW-LDVSHN 492
Query: 646 PFDCTCESI 654
+ S+
Sbjct: 493 RLEALPNSL 501
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 140 bits (354), Expect = 4e-33
Identities = 200/876 (22%), Positives = 360/876 (41%), Gaps = 139/876 (15%)
Query: 36 DCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELC 95
D S L VP DLP VL+++ N + L ++ + S+LT L + N I L+ +
Sbjct: 37 DKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVF 96
Query: 96 QKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLS 155
+ L+ L+L HN+L ++S C + + S K P K+ ++ L+
Sbjct: 97 KFNQDLEYLDLSHNQLQKIS------CHPIVSFRHLDLSFNDFKALPICKEFGNLS-QLN 149
Query: 156 HNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPG 215
GLS+ KL ++ L + L LS + N +K+ E S QI +
Sbjct: 150 FLGLSAMKL-QKLDLLPIAHLHLSYILLD---------LRNYYIKENETESLQI--LNAK 197
Query: 216 CFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTN 275
H + LF +Q+ S+ CL+L N + + N Q+ FL
Sbjct: 198 TLHLVFHPTSLFA--IQVNISVNTLGCLQLTNIKLND---DNCQVF----IKFLSELTRG 248
Query: 276 LTMLDLSYNNLNVVGNDSFAWLPQLEYF-FLEYNNIQHLFSHSLHGLFNVRYLNLKRSFT 334
T+L+ + N++ W + F FL +++L ++L + ++R + FT
Sbjct: 249 STLLNFTLNHIET------TWKCLVRVFQFLWPKPVEYLNIYNLTIIESIR----EEDFT 298
Query: 335 KQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLR 394
+L +L +EH I + +F Y S +
Sbjct: 299 YSKTTLKAL------------TIEH----------ITNQVFLFSQTALYTVFSEMNIMML 336
Query: 395 TLTNETFVSL----AHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQ 450
T+++ F+ + A S LN T+N + + S L LE L L N
Sbjct: 337 TISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKN--------- 387
Query: 451 EWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTI 510
GL+++F++ L +T++ +PSL+ I
Sbjct: 388 ---GLKDLFKVGL-------MTKD----MPSLE--------------------------I 407
Query: 511 LDLSNNNI-ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNL 569
LD+S N++ + + + +E + +L+L N L P + +L+L
Sbjct: 408 LDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLP----------PRIKVLDL 457
Query: 570 ESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKV 629
SN +P +V K L L+ +++ N+L LP + SL L + N ++
Sbjct: 458 HSNKIKSVPKQVVK-LEALQELNVAFNSLTDLPGC--GSFSSLSVLIIDHNSVSHPSADF 514
Query: 630 FGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPE-LSSHYLCNTPPHYHGFPV 688
F + + + + NPF CTCE + FV I++ + + E Y C+ P Y G P+
Sbjct: 515 F-QSCQKMRSIKAGDNPFQCTCE-LREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPL 572
Query: 689 RLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFE-GW--RISFYWNVSVHRVLGFK 745
+ F S + + + T ++L L I+ + W R+ W + R
Sbjct: 573 KDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNI- 631
Query: 746 EIDRQTEQFEYAAYIIHAYKDKDWV-WEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIV 804
++ ++ A+I ++ D WV E +EKED ++ CL ER+F G +E I+
Sbjct: 632 PLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKED--IQICLHERNFVPGKSIVENII 689
Query: 805 NSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHAL 864
N I++S K IFV++ + ++ C ++++ A + +++IL+ LE IP + +
Sbjct: 690 NCIEKSYKSIFVLSPNFVQSEWC-HYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKY 748
Query: 865 CLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK 900
+ + L WP +K + G F ++ A K
Sbjct: 749 HKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMK 784
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 137 bits (344), Expect = 6e-32
Identities = 204/822 (24%), Positives = 349/822 (42%), Gaps = 124/822 (15%)
Query: 127 ELHLMSN-SIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQA 185
E LM+N S ++ P TLDLS+N L + + L+ L+L +N+IQ
Sbjct: 27 ERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQ 86
Query: 186 LKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLEL 245
L + + N L+ L+LS+N++K + + R L N+ P +C E
Sbjct: 87 LDLKTFEF--NKELRYLDLSNNRLKSVTWYLLAGL-RYLDLSFNDFDTMP-----ICEEA 138
Query: 246 ANTS-IRNLSLSNSQLSTTS---------NTTFLGLK----WTNLTMLDLSYNNLNVV-G 290
N S + L LS +++ + NT FLG + + ++ L+ L++V
Sbjct: 139 GNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLP 198
Query: 291 NDSFAWLPQLEYF----FLEYNNIQ---HLFSHSLHGLFNVRYLNLKRSFTKQSISLASL 343
D+ W+ + LE NI S+ + R L+L+ + T S+ L
Sbjct: 199 MDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQ-----RNLSLENAKT----SVLLL 249
Query: 344 PKID---DFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNET 400
K+D D F L+ + H ++E I + F G L + S S T +RT
Sbjct: 250 NKVDLLWDDLFLILQFVWHTSVEHFQIRNVT---FGGKAYLDHNSFDYSNTVMRT----- 301
Query: 401 FVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFE 460
+ L H + + ++KI + L +D+ + LT + +F
Sbjct: 302 -IKLEHVHFRVFYIQQDKIYLL----------LTKMDI------ENLTISNAQMPHMLFP 344
Query: 461 IYLSYNKYLQLTRNSFA--------LVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILD 512
Y + +YL N +P L+ L+L L+ + S S F L LD
Sbjct: 345 NYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETL-SLVSCFANNTPLEHLD 403
Query: 513 LSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESN 572
LS N + + ND+ E + ++L +N L+ P + IL+L +N
Sbjct: 404 LSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLP----------KSIQILDLNNN 453
Query: 573 GFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGP 632
+P E L L+ +++ N L LP +++S+ LN++ N I S F
Sbjct: 454 QIQTVPKETIH-LMALRELNIAFNFLTDLPGCSHFSRLSV--LNIEMNFILSPSLD-FVQ 509
Query: 633 AFRNLTELDMRFNPFDCTCESIAWFVNWIN-ETHTNIPEL--SSHYLCNTPPHYHGFPVR 689
+ + + L+ NPF CTCE N+I ET++ + + S Y C P + G
Sbjct: 510 SCQEVKTLNAGRNPFRCTCE----LKNFIQLETYSEVMMVGWSDSYTCEYPLNLRG---- 561
Query: 690 LFDTSSCKDSAPFELFFMINTSILLIFIFIVLLI----------HFE-GWRISFYWNVSV 738
+ KD EL NT++L++ I +++L+ HF+ W + +
Sbjct: 562 ----TRLKDVHLHEL--SCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQ 615
Query: 739 --HRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVW-EHFSSMEKEDQSLKFCLEERDFEA 795
HRV + ++ + A+I ++ D WV E ++EKED S+ CL E F+
Sbjct: 616 TWHRVRKTTQ-EQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDP 674
Query: 796 GVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEI 855
G E IV+ I++S K IFV++ + +++ C ++ + A +N D IIL+ LE I
Sbjct: 675 GKSISENIVSFIEKSYKSIFVLSPNFVQNEWC-HYEFYFAHHNLFHENSDHIILILLEPI 733
Query: 856 PDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVAL 897
P Y + + + + L WP + + G F L+ A+
Sbjct: 734 PFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAI 775
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 137 bits (344), Expect = 6e-32
Identities = 204/822 (24%), Positives = 349/822 (42%), Gaps = 124/822 (15%)
Query: 127 ELHLMSN-SIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQA 185
E LM+N S ++ P TLDLS+N L + + L+ L+L +N+IQ
Sbjct: 27 ERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQ 86
Query: 186 LKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLEL 245
L + + N L+ L+LS+N++K + + R L N+ P +C E
Sbjct: 87 LDLKTFEF--NKELRYLDLSNNRLKSVTWYLLAGL-RYLDLSFNDFDTMP-----ICEEA 138
Query: 246 ANTS-IRNLSLSNSQLSTTS---------NTTFLGLK----WTNLTMLDLSYNNLNVV-G 290
N S + L LS +++ + NT FLG + + ++ L+ L++V
Sbjct: 139 GNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLP 198
Query: 291 NDSFAWLPQLEYF----FLEYNNIQ---HLFSHSLHGLFNVRYLNLKRSFTKQSISLASL 343
D+ W+ + LE NI S+ + R L+L+ + T S+ L
Sbjct: 199 MDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQ-----RNLSLENAKT----SVLLL 249
Query: 344 PKID---DFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNET 400
K+D D F L+ + H ++E I + F G L + S S T +RT
Sbjct: 250 NKVDLLWDDLFLILQFVWHTSVEHFQIRNVT---FGGKAYLDHNSFDYSNTVMRT----- 301
Query: 401 FVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFE 460
+ L H + + ++KI + L +D+ + LT + +F
Sbjct: 302 -IKLEHVHFRVFYIQQDKIYLL----------LTKMDI------ENLTISNAQMPHMLFP 344
Query: 461 IYLSYNKYLQLTRNSFA--------LVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILD 512
Y + +YL N +P L+ L+L L+ + S S F L LD
Sbjct: 345 NYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETL-SLVSCFANNTPLEHLD 403
Query: 513 LSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESN 572
LS N + + ND+ E + ++L +N L+ P + IL+L +N
Sbjct: 404 LSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLP----------KSIQILDLNNN 453
Query: 573 GFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGP 632
+P E L L+ +++ N L LP +++S+ LN++ N I S F
Sbjct: 454 QIQTVPKETIH-LMALRELNIAFNFLTDLPGCSHFSRLSV--LNIEMNFILSPSLD-FVQ 509
Query: 633 AFRNLTELDMRFNPFDCTCESIAWFVNWIN-ETHTNIPEL--SSHYLCNTPPHYHGFPVR 689
+ + + L+ NPF CTCE N+I ET++ + + S Y C P + G
Sbjct: 510 SCQEVKTLNAGRNPFRCTCE----LKNFIQLETYSEVMMVGWSDSYTCEYPLNLRG---- 561
Query: 690 LFDTSSCKDSAPFELFFMINTSILLIFIFIVLLI----------HFE-GWRISFYWNVSV 738
+ KD EL NT++L++ I +++L+ HF+ W + +
Sbjct: 562 ----TRLKDVHLHEL--SCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQ 615
Query: 739 --HRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVW-EHFSSMEKEDQSLKFCLEERDFEA 795
HRV + ++ + A+I ++ D WV E ++EKED S+ CL E F+
Sbjct: 616 TWHRVRKTTQ-EQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDP 674
Query: 796 GVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEI 855
G E IV+ I++S K IFV++ + +++ C ++ + A +N D IIL+ LE I
Sbjct: 675 GKSISENIVSFIEKSYKSIFVLSPNFVQNEWC-HYEFYFAHHNLFHENSDHIILILLEPI 733
Query: 856 PDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVAL 897
P Y + + + + L WP + + G F L+ A+
Sbjct: 734 PFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAI 775
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 132 bits (332), Expect = 1e-30
Identities = 196/806 (24%), Positives = 339/806 (42%), Gaps = 93/806 (11%)
Query: 145 KQKNLITLDLSHNGLSSTKLGTQVQL-----ENLQELLLSNNKIQALKSEELDIFANSSL 199
+ N +L NG+ G+ + E ++ L LSNN+I + + +L N L
Sbjct: 21 ESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVN--L 78
Query: 200 KKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQ 259
+ L L+SN I F ++G L L L+ L +L+ L++ + NL L N
Sbjct: 79 QALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS-NLSSSWFKPLSSLTFLNL-LGNPY 136
Query: 260 LSTTSNTTFLGLKWTNLTMLDL-SYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSL 318
+ + F L T L +L + + + + FA L LE ++ +++Q SL
Sbjct: 137 KTLGETSLFSHL--TKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSL 194
Query: 319 HGLFNVRYLNLKRSFTKQSISLASL---------------PKIDDFSFQWLKCLE----- 358
+ NV +L L KQ I L + +D F F L E
Sbjct: 195 KSIQNVSHLILHM---KQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLI 251
Query: 359 ------HLNMEDNDIPGIKS--NMFTGLINLKYLSLS-NSFTSLRTLTNETFVSLAHSPL 409
++ + D + + N +GL+ L++ + N + R N+ + P
Sbjct: 252 KKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVID----PG 307
Query: 410 HILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQE---------LTGQEWRGLENI-F 459
+ LT ++ F L L L + I E L Q + LE +
Sbjct: 308 KVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDL 367
Query: 460 EIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIA 519
L +YL+ + A PSLQ L+LR+ L +++ + L+NLT +D+S N+
Sbjct: 368 SENLMVEEYLKNSACEDAW-PSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFH 426
Query: 520 NINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPV 579
++ + + EK++ L+L + H+ G K L L + N N F
Sbjct: 427 SM-PETCQWPEKMKYLNLSSTRI-----HSVTG---CIPKTLEILDVSNNNLNLFS---- 473
Query: 580 EVFKDLFELKIIDLGLNNLNTLP-ASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLT 638
+L +LK + + N L TLP AS+ + LK + +N IT+ K+ +F L
Sbjct: 474 ---LNLPQLKELYISRNKLMTLPDASLLPMLLVLK---ISRNAITTFSKEQLD-SFHTLK 526
Query: 639 ELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVR--LFDTSSC 696
L+ N F C+CE ++ F + + ++YLC++P H G V+ S C
Sbjct: 527 TLEAGGNNFICSCEFLS-FTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSEC 585
Query: 697 KDSAPFELFFMINTSILLIFIFIVLLIHFEG-WRISFYWN-VSVHRVLGFKEIDRQTEQF 754
+A M LLI + VL F G W + W + R K +
Sbjct: 586 HRTALVS--GMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKR----KPRKAPSRNI 639
Query: 755 EYAAYIIHAYKDKDWVWEHF-SSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKI 813
Y A++ ++ +D WV +E + K CL +RDF G + ++ I++SI++S K
Sbjct: 640 CYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKT 699
Query: 814 IFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKS 873
+FV++ + +K CK +++ + + ++N D+ IL+ LE I + C R + +
Sbjct: 700 VFVLSENFVKSEWCK-YELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNT 758
Query: 874 HCILNWPVQKERIGAFRHKLQVALGS 899
L WP+ + + F L+ A+ S
Sbjct: 759 KTYLEWPMDEAQREGFWVNLRAAIKS 784
Score = 56.2 bits (134), Expect = 1e-07
Identities = 116/543 (21%), Positives = 223/543 (41%), Gaps = 103/543 (18%)
Query: 36 DCSHLKLTQVPD-DLP--TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEP 92
D S+ ++T + + DL N+ L LT N + + +F+ L LD+ +N +S L
Sbjct: 58 DLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSS 117
Query: 93 ELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLM----SNSIQKIKNNPFVKQKN 148
+ L L LNL N L + + ++LT+L ++ ++ KI+ F
Sbjct: 118 SWFKPLSSLTFLNLLGNPYKTLGET--SLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTF 175
Query: 149 LITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQ 208
L L++ + L S + + ++N+ L+L + Q + E+ + SS++ LEL
Sbjct: 176 LEELEIDASDLQSYEPKSLKSIQNVSHLIL--HMKQHILLLEIFVDVTSSVECLELRDTD 233
Query: 209 IKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTF 268
+ F +L N+ I+ + N ++ T + F
Sbjct: 234 LDTFH------------------------FSELSTGETNSLIKKFTFRNVKI--TDESLF 267
Query: 269 LGLKWTNLT--MLDLSYNN--LNVVGNDSFAWLPQ-LEYFFLEYNNIQHLFSHSLHGLFN 323
+K N +L+L +++ LN VGN + + ++ +E I+ L + ++
Sbjct: 268 QVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYD 327
Query: 324 VRYL-NLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLK 382
+ L +L + ++ + + + Q LK LE+L++ +N L+ +
Sbjct: 328 LSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSEN------------LMVEE 375
Query: 383 YLSLS---NSFTSLRTL------------TNETFVSLAHSPLHILNLTKNKISKIESDAF 427
YL S +++ SL+TL T ET ++L + L ++++KN + +
Sbjct: 376 YLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKN--LTNIDISKNSFHSM-PETC 432
Query: 428 SWLGHLEVLDLGLNEIGQELTGQEWRGLE---------NIFEIYLSYNKYLQLTRNSFAL 478
W ++ L+L I +TG + LE N+F + L K L ++RN
Sbjct: 433 QWPEKMKYLNLSSTRI-HSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMT 491
Query: 479 VPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQ 538
+P D+S P L +L +S N I + + L+ L+ L+
Sbjct: 492 LP---------------DASLLPM-----LLVLKISRNAITTFSKEQLDSFHTLKTLEAG 531
Query: 539 HNN 541
NN
Sbjct: 532 GNN 534
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 130 bits (327), Expect = 6e-30
Identities = 167/692 (24%), Positives = 282/692 (40%), Gaps = 101/692 (14%)
Query: 23 SSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDV 82
S + CT S+ + DC L ++P +LP I + L N ++ +PA FT+Y +L +D+
Sbjct: 279 SCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDI 338
Query: 83 GFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNP 142
N IS + P+ Q L L L L N++++++ F +L L L +N I ++ N
Sbjct: 339 SKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNT 398
Query: 143 FVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKL 202
F +NL L L N L + G L+++Q L L+ N + LK L
Sbjct: 399 FQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQN----------PFVCDCHLKWL 448
Query: 203 E--LSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
L N I+ C L K ++ + R S S
Sbjct: 449 ADYLQDNPIETSGARC---------------SSPRRLANKRISQIKSKKFR-CSGSEDYR 492
Query: 261 STTSNTTFLGLKWTNL-----TMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFS 315
S S+ F+ L T++D S L + + ++ L L N + L +
Sbjct: 493 SRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLR---LNDNEVSVLEA 549
Query: 316 HSL-HGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNM 374
+ L N+R +NL + K+ + + +F ++ L + N + + +
Sbjct: 550 TGIFKKLPNLRKINLSNNKIKE---------VREGAFDGAASVQELMLTGNQLETVHGRV 600
Query: 375 FTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLE 434
F GL LK L L ++ + ++N+TF L S + +L+L N+I+ I AF+ L L
Sbjct: 601 FRGLSGLKTLMLRSNL--IGCVSNDTFAGL--SSVRLLSLYDNRITTITPGAFTTLVSLS 656
Query: 435 VLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTR----NSFALVP-SLQRLMLRR 489
++L N W G K+L+ R N P L+ + ++
Sbjct: 657 TINLLSNPFNCN-CHLAWLG------------KWLRKRRIVSGNPRCQKPFFLKEIPIQD 703
Query: 490 VALK------NVDSS-----PSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQ 538
VA++ N +SS P Q T++ SN + + M + + +L L+
Sbjct: 704 VAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELY---LE 760
Query: 539 HNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNL 598
N+L + + L L HL +++L +N + F ++ L + L N L
Sbjct: 761 GNHLTAVPRE---------LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 811
Query: 599 NTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFV 658
+P FN SL+ L L N I+SV + F +L+ L + NP C C S+ W
Sbjct: 812 RCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFND-LTSLSHLALGTNPLHCDC-SLRWLS 869
Query: 659 NWINE-------THTNIPE-LSSHYLCNTPPH 682
W+ + PE ++ L TP H
Sbjct: 870 EWVKAGYKEPGIARCSSPEPMADRLLLTTPTH 901
Score = 86.7 bits (213), Expect = 9e-17
Identities = 169/740 (22%), Positives = 271/740 (36%), Gaps = 149/740 (20%)
Query: 26 TKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFN 85
TKCT S DC L L VP +P N L+L N + R+ +F L L + N
Sbjct: 36 TKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDN 95
Query: 86 TISKLE-----------------------PELC-QKLPML-------------------- 101
+S +E PEL Q P L
Sbjct: 96 QVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRG 155
Query: 102 ----KVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHN 157
K L L +N +S + D F +L L L +N+I +I F + TL L N
Sbjct: 156 ITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSN 215
Query: 158 GLSSTKLGTQVQLENLQELLLSNNKIQ----ALKSEELDIFANSSLKKLEL--------- 204
L L L + L + + L F + ++K E
Sbjct: 216 -----HLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEP 270
Query: 205 ---SSNQIKEFSP-GCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
++N I SP C + I G L +++ +L E I + L + +
Sbjct: 271 PSCNANSISCPSPCTCSNNIVDCRGKGL--MEIPANLPE---------GIVEIRLEQNSI 319
Query: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHG 320
F K L +D+S N ++ + D+F L L L N I + G
Sbjct: 320 KAIPAGAFTQYK--KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDG 377
Query: 321 LFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLIN 380
L +++ L L + + + +FQ L+ L L++ DN + I +F L +
Sbjct: 378 LVSLQLLLLNAN---------KINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQS 428
Query: 381 LKYLSLS-NSFTS---LRTLTN-------ETFVSLAHSPLHILNLTKNKISKIESDAFSW 429
++ L L+ N F L+ L + ET + SP + N +IS+I+S F
Sbjct: 429 IQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLAN---KRISQIKSKKFRC 485
Query: 430 LGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRR 489
G + +E +L E E + S K +++ + V L RL
Sbjct: 486 SGSEDYRSRFSSECFMDLVCPEKCRCEGTI-VDCSNQKLVRIPSHLPEYVTDL-RLNDNE 543
Query: 490 VALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHA 549
V+ V + F+ L NL ++LSNN I + + +G ++ L L N L +
Sbjct: 544 VS---VLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVH--- 597
Query: 550 NPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQ 609
G ++ +GLS L L L SN + + F L ++++ L N + T+ F
Sbjct: 598 ---GRVF--RGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTL 652
Query: 610 VSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIP 669
VSL ++NL NPF+C C +AW W+ +
Sbjct: 653 VSLSTINLLS-------------------------NPFNCNCH-LAWLGKWLRKRRI--- 683
Query: 670 ELSSHYLCNTPPHYHGFPVR 689
+S + C P P++
Sbjct: 684 -VSGNPRCQKPFFLKEIPIQ 702
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 123 bits (308), Expect = 9e-28
Identities = 163/588 (27%), Positives = 257/588 (43%), Gaps = 82/588 (13%)
Query: 18 GMLCASSTTKCTVSHE-VADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQ 76
G S C S E V DC + L + P DLP + L+L +NQL
Sbjct: 110 GPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQL------------- 156
Query: 77 LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQ--LSDKTFAFCTNLTELHLMSNS 134
K+ PE +L L+ LNLQ+N L+ L +K F TNL L+L +N
Sbjct: 157 -----------EKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANN- 204
Query: 135 IQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIF 194
K+ P LI++D + N L+ T Q NL+ + L NNK+ +
Sbjct: 205 --KLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN 262
Query: 195 ANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQL---GPSLTEKLCLELANTSIR 251
+S+++ L LSSN ++ H L+ L L N +L P +L +S+R
Sbjct: 263 GSSNVEVLILSSNFLRHVPK---HLPPALYKLHLKNNKLEKIPPGAFSEL------SSLR 313
Query: 252 NLSLSNSQLST--TSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQ-LEYFFLEYN 308
L L N+ L+ N TF K ++L LDLS NNL+ V A LP+ L LE N
Sbjct: 314 ELYLQNNYLTDEGLDNETF--WKLSSLEYLDLSSNNLSRVP----AGLPRSLVLLHLEKN 367
Query: 309 NIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIP 368
I+ + ++ L + ++ YL L + ++ I +FQ LK L +++ +N +
Sbjct: 368 AIRSVDANVLTPIRSLEYLLLHSNQLREQ-------GIHPLAFQGLKRLHTVHLYNNALE 420
Query: 369 GIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS--KIESDA 426
+ S + + L + L N T + E F + L LNL+ N+I+ ++ DA
Sbjct: 421 RVPSGLPRRVRTL--MILHNQITG---IGREDFATTYF--LEELNLSYNRITSPQVHRDA 473
Query: 427 FSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLM 486
F L L LDL N + G N+ + + N+ L R + + L+ L
Sbjct: 474 FRKLRLLRSLDLSGNRLHTLPPGLP----RNVHVLKVKRNELAALARGALVGMAQLRELY 529
Query: 487 LRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGL-EKLEILDLQHNNLARL 545
L L++ P + L +L +LD++ N + I EGL E LE L LQ+N ++ +
Sbjct: 530 LTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP----EGLPESLEYLYLQNNKISAV 585
Query: 546 WKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDL 593
+A P LKG+ L + F+ L L+++D+
Sbjct: 586 PANAFDSTP--NLKGI----FLRFNKLAVGSVVDSAFRRLKHLQVLDI 627
Score = 84.3 bits (207), Expect = 5e-16
Identities = 123/491 (25%), Positives = 205/491 (41%), Gaps = 82/491 (16%)
Query: 202 LELSSNQIKEFSPGCFHAIGRLFGLFLNNVQL-GPSLTEKLCLELANTSIRNLSLSNSQL 260
L L +NQ+++ P + RL L L N +L L EK L N + L L+N++L
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTN--LNYLYLANNKL 206
Query: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQH--LFSHSL 318
+ FL L +D + N L + +F P L +L N + L +
Sbjct: 207 TLAPR--FLP---NALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMF 261
Query: 319 HGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGL 378
+G NV L L +F L +PK L L++++N + I F+ L
Sbjct: 262 NGSSNVEVLILSSNF------LRHVPK------HLPPALYKLHLKNNKLEKIPPGAFSEL 309
Query: 379 INLKYLSLSNSFTSLRTLTNETFVSLAH-------------------SPLHILNLTKNKI 419
+L+ L L N++ + L NETF L+ L +L+L KN I
Sbjct: 310 SSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAI 369
Query: 420 SKIESDAFSWLGHLEVLDLGLNEIGQE-LTGQEWRGLENIFEIYLSYNKYLQ-------- 470
++++ + + LE L L N++ ++ + ++GL+ + ++L YN L+
Sbjct: 370 RSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHL-YNNALERVPSGLPR 428
Query: 471 --------------LTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNN 516
+ R FA L+ L L + + F+ LR L LDLS N
Sbjct: 429 RVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGN 488
Query: 517 NIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDE 576
+ + + + +L ++ N LA L + A L G++ L L L SN
Sbjct: 489 RLHTLPPGL---PRNVHVLKVKRNELAALARGA--------LVGMAQLRELYLTSNRLRS 537
Query: 577 --IPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAF 634
+ + DL L+++D+ N L +P + SL+ L LQ N I++V F +
Sbjct: 538 RALGPRAWVDLAHLQLLDIAGNQLTEIPEGL---PESLEYLYLQNNKISAVPANAF-DST 593
Query: 635 RNLTELDMRFN 645
NL + +RFN
Sbjct: 594 PNLKGIFLRFN 604
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 121 bits (303), Expect = 3e-27
Identities = 120/436 (27%), Positives = 200/436 (45%), Gaps = 33/436 (7%)
Query: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQ 311
+L + N+ ++ + + FL + + L L + N L+ + +F L L Y L N +Q
Sbjct: 63 SLQILNTHITELNESPFLNI--SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQ 120
Query: 312 HLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIK 371
L GL ++ L L + L +I F L+ L + N + I
Sbjct: 121 VLPIGLFQGLDSLESLLLSSN---------QLLQIQPAHFSQCSNLKELQLHGNHLEYIP 171
Query: 372 SNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLG 431
F L+ L L+L + SL ++ F L + L +L L +N+++ I F L
Sbjct: 172 DGAFDHLVGLTKLNLGKN--SLTHISPRVFQHLGN--LQVLRLYENRLTDIPMGTFDGLV 227
Query: 432 HLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVA 491
+L+ L L N+IG G + N+ +YLS N QL + F +P L RL L +
Sbjct: 228 NLQELALQQNQIGLLSPGL-FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 286
Query: 492 LKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANP 551
LK + S F P+ NL L L +N+I+++ D++ L +L++L L N ++ + +P
Sbjct: 287 LKEL--SLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI----SP 340
Query: 552 GGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVS 611
G GL+ L L+L +N ++ VF+ L L+ I L N L LP ++F N
Sbjct: 341 GA----FNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNG 396
Query: 612 LKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPEL 671
L ++ LQ N + ++ +F L EL + NP+ C + I NW+ N P L
Sbjct: 397 LMAIQLQNNQLENLPLGIF-DHLGKLCELRLYDNPWRCDSD-ILPLRNWL---LLNQPRL 451
Query: 672 SSHY--LCNTPPHYHG 685
+ +C +P + G
Sbjct: 452 GTDTVPVCFSPANVRG 467
Score = 111 bits (278), Expect = 3e-24
Identities = 107/407 (26%), Positives = 176/407 (43%), Gaps = 51/407 (12%)
Query: 11 WGGLLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAA 69
WG G+ ++CT S +C+ ++ VP LP N L + + + L +
Sbjct: 22 WGA----GLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNES 77
Query: 70 NFTRYSQLTSLDVGFNTISKLEP------------------------ELCQKLPMLKVLN 105
F S L +L + N +S++ P L Q L L+ L
Sbjct: 78 PFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLL 137
Query: 106 LQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLG 165
L N+L Q+ F+ C+NL EL L N ++ I + F L L+L N L+
Sbjct: 138 LSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPR 197
Query: 166 TQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFG 225
L NLQ L L N++ + D N L++L L NQI SPG FH L
Sbjct: 198 VFQHLGNLQVLRLYENRLTDIPMGTFDGLVN--LQELALQQNQIGLLSPGLFHNNHNLQR 255
Query: 226 LFLNN---VQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLS 282
L+L+N QL PS+ +L + L+L + L S F + NL L L
Sbjct: 256 LYLSNNHISQLPPSIFMQL------PQLNRLTLFGNSLKELSLGIFGPM--PNLRELWLY 307
Query: 283 YNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLAS 342
N+++ + ++ F+ L QL+ L N I + + +GL +R L+L + +
Sbjct: 308 DNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN---------A 358
Query: 343 LPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNS 389
L +D F+ L L+++++++N + + N+F + L + L N+
Sbjct: 359 LQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNN 405
Score = 73.2 bits (178), Expect = 1e-12
Identities = 77/269 (28%), Positives = 111/269 (41%), Gaps = 46/269 (17%)
Query: 41 KLTQVPD---DLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQK 97
+LT +P D N+ L L NQ+ L F L L + N IS+L P + +
Sbjct: 214 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQ 273
Query: 98 LPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHN 157
LP L L L N L +LS F NL EL L N I + +N F + L L LS N
Sbjct: 274 LPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 333
Query: 158 GLSSTKLGTQVQLENLQELLLSNNKIQ----------------ALKSEEL-----DIFAN 196
+S G L L+EL L N +Q +L++ L +IFAN
Sbjct: 334 QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFAN 393
Query: 197 -SSLKKLELSSNQIKEFSPGCFHAIGRLF--------------------GLFLNNVQLGP 235
+ L ++L +NQ++ G F +G+L L LN +LG
Sbjct: 394 VNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGT 453
Query: 236 SLTEKLCLELANTSIRNLSLSNSQLSTTS 264
T +C AN ++L + N ++ S
Sbjct: 454 D-TVPVCFSPANVRGQSLIIINVNVAVPS 481
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 121 bits (303), Expect = 3e-27
Identities = 120/436 (27%), Positives = 200/436 (45%), Gaps = 33/436 (7%)
Query: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQ 311
+L + N+ ++ + + FL + + L L + N L+ + +F L L Y L N +Q
Sbjct: 57 SLQILNTHITELNESPFLNI--SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQ 114
Query: 312 HLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIK 371
L GL ++ L L + L +I F L+ L + N + I
Sbjct: 115 VLPIGLFQGLDSLESLLLSSN---------QLLQIQPAHFSQCSNLKELQLHGNHLEYIP 165
Query: 372 SNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLG 431
F L+ L L+L + SL ++ F L + L +L L +N+++ I F L
Sbjct: 166 DGAFDHLVGLTKLNLGKN--SLTHISPRVFQHLGN--LQVLRLYENRLTDIPMGTFDGLV 221
Query: 432 HLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVA 491
+L+ L L N+IG G + N+ +YLS N QL + F +P L RL L +
Sbjct: 222 NLQELALQQNQIGLLSPGL-FHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 280
Query: 492 LKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANP 551
LK + S F P+ NL L L +N+I+++ D++ L +L++L L N ++ + +P
Sbjct: 281 LKEL--SLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI----SP 334
Query: 552 GGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVS 611
G GL+ L L+L +N ++ VF+ L L+ I L N L LP ++F N
Sbjct: 335 GA----FNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNG 390
Query: 612 LKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPEL 671
L ++ LQ N + ++ +F L EL + NP+ C + I NW+ N P L
Sbjct: 391 LMAIQLQNNQLENLPLGIF-DHLGKLCELRLYDNPWRCDSD-ILPLRNWL---LLNQPRL 445
Query: 672 SSHY--LCNTPPHYHG 685
+ +C +P + G
Sbjct: 446 GTDTVPVCFSPANVRG 461
Score = 111 bits (278), Expect = 3e-24
Identities = 107/407 (26%), Positives = 176/407 (43%), Gaps = 51/407 (12%)
Query: 11 WGGLLPFGMLCASSTTKCTVSH-EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAA 69
WG G+ ++CT S +C+ ++ VP LP N L + + + L +
Sbjct: 16 WGA----GLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNES 71
Query: 70 NFTRYSQLTSLDVGFNTISKLEP------------------------ELCQKLPMLKVLN 105
F S L +L + N +S++ P L Q L L+ L
Sbjct: 72 PFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLL 131
Query: 106 LQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLG 165
L N+L Q+ F+ C+NL EL L N ++ I + F L L+L N L+
Sbjct: 132 LSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPR 191
Query: 166 TQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFG 225
L NLQ L L N++ + D N L++L L NQI SPG FH L
Sbjct: 192 VFQHLGNLQVLRLYENRLTDIPMGTFDGLVN--LQELALQQNQIGLLSPGLFHNNHNLQR 249
Query: 226 LFLNN---VQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLS 282
L+L+N QL PS+ +L + L+L + L S F + NL L L
Sbjct: 250 LYLSNNHISQLPPSIFMQL------PQLNRLTLFGNSLKELSLGIFGPM--PNLRELWLY 301
Query: 283 YNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLAS 342
N+++ + ++ F+ L QL+ L N I + + +GL +R L+L + +
Sbjct: 302 DNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN---------A 352
Query: 343 LPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNS 389
L +D F+ L L+++++++N + + N+F + L + L N+
Sbjct: 353 LQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNN 399
Score = 73.2 bits (178), Expect = 1e-12
Identities = 77/269 (28%), Positives = 111/269 (41%), Gaps = 46/269 (17%)
Query: 41 KLTQVPD---DLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQK 97
+LT +P D N+ L L NQ+ L F L L + N IS+L P + +
Sbjct: 208 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQ 267
Query: 98 LPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHN 157
LP L L L N L +LS F NL EL L N I + +N F + L L LS N
Sbjct: 268 LPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 327
Query: 158 GLSSTKLGTQVQLENLQELLLSNNKIQ----------------ALKSEEL-----DIFAN 196
+S G L L+EL L N +Q +L++ L +IFAN
Sbjct: 328 QISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFAN 387
Query: 197 -SSLKKLELSSNQIKEFSPGCFHAIGRLF--------------------GLFLNNVQLGP 235
+ L ++L +NQ++ G F +G+L L LN +LG
Sbjct: 388 VNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGT 447
Query: 236 SLTEKLCLELANTSIRNLSLSNSQLSTTS 264
T +C AN ++L + N ++ S
Sbjct: 448 D-TVPVCFSPANVRGQSLIIINVNVAVPS 475
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 118 bits (295), Expect = 3e-26
Identities = 186/892 (20%), Positives = 350/892 (39%), Gaps = 159/892 (17%)
Query: 31 SHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKL 90
S + D S L VP DL T+LN++ N + L ++ S+L L + N I L
Sbjct: 25 SEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYL 84
Query: 91 EPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLI 150
+ + + L+ L+L HN+L ++S NL L L N+ + P K+ +
Sbjct: 85 DISVFKFNQELEYLDLSHNKLVKISCHP---TVNLKHLDLSFNAFDAL---PICKEFGNM 138
Query: 151 TLDLSHNGLSSTKLGTQVQLE----NLQELLLSNNKIQALKSEELDIFANSSLKKLELSS 206
+ L GLS+T L L N+ ++LL + K +
Sbjct: 139 S-QLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKED----------------P 181
Query: 207 NQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSN- 265
+++F+ H + F N + L+++ ++ NL LSN + N
Sbjct: 182 EGLQDFNTESLHIV------FPTNKEF------HFILDVSVKTVANLELSNIKCVLEDNK 229
Query: 266 ----TTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGL 321
+ L TN + +L+ NN+ N L + + + Y +I ++ L G
Sbjct: 230 CSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNV---KLQGQ 286
Query: 322 FNVRYLNLKRSFTKQSISLASLPKI--DDFSFQW---LKCLEHLNMEDNDIPGIKSNMFT 376
+ R + ++ S+ S+ ++ D F F + ++N+++ + G + M
Sbjct: 287 LDFRDFD----YSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSG--TRMVH 340
Query: 377 GLINLKYLSLSNSFTSLRTLTNETFVSLAH-SPLHILNLTKNKISKIE--SDAFSWLGHL 433
L K + S LT+ F + H + L L L N++ ++ ++ + + L
Sbjct: 341 MLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSL 400
Query: 434 EVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALK 493
+ LD+ N + + + +++ + +S N LT F +P
Sbjct: 401 QQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSN---ILTDTIFRCLPP------------ 445
Query: 494 NVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGG 553
+ +LDL +N I +I +++ LE L+ L++ N+L L PG
Sbjct: 446 -------------RIKVLDLHSNKIKSIPKQVVK-LEALQELNVAFNSLTDL-----PG- 485
Query: 554 PIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLK 613
S L +L ++ N + F+ +++ I G N
Sbjct: 486 ----CGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDN----------------- 524
Query: 614 SLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPE-LS 672
PF CTCE + FV I++ + + E
Sbjct: 525 --------------------------------PFQCTCE-LGEFVKNIDQVSSEVLEGWP 551
Query: 673 SHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFE-GW--R 729
Y C+ P Y G ++ F S + + ++ T ++L L + + W R
Sbjct: 552 DSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLR 611
Query: 730 ISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVW-EHFSSMEKEDQSLKFCL 788
+ W + R ++ ++ A+I ++ D WV E ++EKE ++ CL
Sbjct: 612 MVCQWTQTRRRARNI-PLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKE--GMQICL 668
Query: 789 EERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSII 848
ER+F G +E I+ I++S K IFV++ + ++ C ++++ A + +S+I
Sbjct: 669 HERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWC-HYELYFAHHNLFHEGSNSLI 727
Query: 849 LVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK 900
L+ LE IP Y + + + + L WP +K + G F L+ A+ K
Sbjct: 728 LILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIK 779
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 118 bits (295), Expect = 3e-26
Identities = 131/453 (28%), Positives = 201/453 (44%), Gaps = 42/453 (9%)
Query: 20 LCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTS 79
LCA+ + C V DCS LT VP+ L L+++ N + +LP F + L
Sbjct: 28 LCAAPCS-CDGDRRV-DCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEE 85
Query: 80 LDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIK 139
L + N +S + P+ L LKVL LQ+N+L + + + L L L +N I +
Sbjct: 86 LQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVP 145
Query: 140 NNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN-SS 198
+ F L L L N L+ + L LQ L L+ NKI ++ F N SS
Sbjct: 146 EDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPD---FAFTNLSS 202
Query: 199 LKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLG--PSLTEKLCLELANTSIRNLSLS 256
L L L +N+I+ S CF + L L LN LG P + L S++ L
Sbjct: 203 LVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKAL------PSLKELGFH 256
Query: 257 NSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSH 316
++ +S + F G L + L N L+ VGN +F +N+ L S
Sbjct: 257 SNSISVIPDGAFDGNPL--LRTIHLYDNPLSFVGNSAF-------------HNLSDLHSL 301
Query: 317 SLHGLFNV-RYLNLKRSFTKQSISL--ASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSN 373
+ G V ++ NL + +S++L + I + Q K L L++ N+I + S
Sbjct: 302 VIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS- 360
Query: 374 MFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHL 433
F G L+ +SL + + + TF L L IL+L++N I +I S AF+ LG +
Sbjct: 361 -FNGCHALEEISLQRN--QIYQIKEGTFQGLI--SLRILDLSRNLIHEIHSRAFATLGPI 415
Query: 434 EVLDLGLNEIGQELTGQEWRGLENIFEIYLSYN 466
LD+ N ELT GL + ++ L N
Sbjct: 416 TNLDVSFN----ELTSFPTEGLNGLNQLKLVGN 444
Score = 104 bits (260), Expect = 3e-22
Identities = 100/390 (25%), Positives = 171/390 (43%), Gaps = 51/390 (13%)
Query: 279 LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSI 338
LD+S NN+ + D+F P LE L N++ + +L GL ++ L L+ +
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNN------ 115
Query: 339 SLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTN 398
L + + + L L+ L ++ N I + + F GL+ L++L L ++ +LT
Sbjct: 116 ---QLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDN-----SLTE 167
Query: 399 ETFVSLAHSP-LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLEN 457
L++ P L L L NKIS I AF+ L L VL L N+I + L+ + GL+N
Sbjct: 168 VPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKI-RSLSQHCFDGLDN 226
Query: 458 IFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNN 517
+ + L+YN + + AL PSL+ L ++ + PL L + L +N
Sbjct: 227 LETLDLNYNNLGEFPQAIKAL-PSLKELGFHSNSISVIPDGAFDGNPL--LRTIHLYDNP 283
Query: 518 IANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEI 577
++ + + L L L ++ ++ + + + L G HL L L I
Sbjct: 284 LSFVGNSAFHNLSDLHSLVIRGASMVQQFPN---------LTGTVHLESLTLTGTKISSI 334
Query: 578 PVEVFKDLFELKIIDLGLNNLNTLPA----------------------SVFNNQVSLKSL 615
P + ++ L+ +DL NN+ LP+ F +SL+ L
Sbjct: 335 PNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRIL 394
Query: 616 NLQKNLITSVEKKVFGPAFRNLTELDMRFN 645
+L +NLI + + F +T LD+ FN
Sbjct: 395 DLSRNLIHEIHSRAFA-TLGPITNLDVSFN 423
Score = 31.6 bits (70), Expect = 3.5
Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 10/120 (8%)
Query: 567 LNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVE 626
L++ N ++P + FK+ L+ + L N+L+ + + LK L LQ N + +V
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 627 KKVFGPAFRNLTEL-DMRFNPFDCTCESIAWFVNWINETH-----TNIPELSSHYLCNTP 680
+ A R L+ L +R + T F + H ++ E+ H L N P
Sbjct: 122 SE----AIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLP 177
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 116 bits (290), Expect = 1e-25
Identities = 158/662 (23%), Positives = 269/662 (40%), Gaps = 84/662 (12%)
Query: 28 CTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTI 87
CT S+ + DC LT++P +LP IT + L N ++ +P F+ Y +L +D+ N I
Sbjct: 277 CTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI 336
Query: 88 SKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQK 147
S+L P+ Q L L L L N++++L F +L L L +N I ++ + F
Sbjct: 337 SELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLH 396
Query: 148 NLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLE--LS 205
NL L L N L + GT L +Q + L+ N + LK L L
Sbjct: 397 NLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN----------PFICDCHLKWLADYLH 446
Query: 206 SNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKL-CLELANTSIRNLSLSNSQLSTTS 264
+N I+ C L N ++G ++K C I S+L S
Sbjct: 447 TNPIETSGARCTSP------RRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKL---S 497
Query: 265 NTTFLGLKWTNL-----TMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLH 319
F L T +D S LN + + +L E+ ++
Sbjct: 498 GDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE------AT 551
Query: 320 GLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLI 379
G+F K +F+ I+ I++ +F+ + + + N + ++ MF GL
Sbjct: 552 GIFKKLPQLRKINFSNNKIT-----DIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLE 606
Query: 380 NLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLG 439
+LK L L ++ + + N++F+ L S + +L+L N+I+ + AF L L L+L
Sbjct: 607 SLKTLMLRSN--RITCVGNDSFIGL--SSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLL 662
Query: 440 LNEIGQELTGQEWRGLENIFEIYLS--YNKYLQLTRNSFALVP-SLQRLMLRRVALK--- 493
N N + +L K +T N P L+ + ++ VA++
Sbjct: 663 ANPFNC-----------NCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFT 711
Query: 494 ----NVDSSPSPFQPL-RNLTILDLSNNNIANINDDMLEGLEK-----LEILDLQHNNLA 543
N D+S SP T LD + ++ L+ L K + L L N
Sbjct: 712 CDDGNDDNSCSPLSRCPTECTCLD----TVVRCSNKGLKVLPKGIPRDVTELYLDGNQFT 767
Query: 544 RLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPA 603
+ K L HL +++L +N + + F ++ +L + L N L +P
Sbjct: 768 LVPKE---------LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPP 818
Query: 604 SVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINE 663
F+ SL+ L+L N I+ V + F L+ L + NP C C ++ W +W+
Sbjct: 819 RTFDGLKSLRLLSLHGNDISVVPEGAFND-LSALSHLAIGANPLYCDC-NMQWLSDWVKS 876
Query: 664 TH 665
+
Sbjct: 877 EY 878
Score = 105 bits (261), Expect = 2e-22
Identities = 167/738 (22%), Positives = 264/738 (35%), Gaps = 150/738 (20%)
Query: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
+C+ S DC L L VP ++P N L+L N + R+ +F L L + N
Sbjct: 31 QCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENK 90
Query: 87 ISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQ 146
IS +E Q L L+ L L N L + F L L L N IQ I F
Sbjct: 91 ISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGA 150
Query: 147 KNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNN--------------KIQALKSEELD 192
++ L L +N +S + G L +L+ L L+NN K++ + +
Sbjct: 151 VDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNN 210
Query: 193 IFAN-------------------------SSLKKLELSSNQIKEF---------SPGCFH 218
++ + S L+ ++ Q +EF +P C
Sbjct: 211 LYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSV 270
Query: 219 AIGRLFGLFLNNVQ--LGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNL 276
NN+ G LTE + L T I + L + + F K L
Sbjct: 271 LHCPAACTCSNNIVDCRGKGLTE-IPTNLPET-ITEIRLEQNTIKVIPPGAFSPYK--KL 326
Query: 277 TMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQ 336
+DLS N ++ + D+F L L L N I L GLF+++ L L
Sbjct: 327 RRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLL------- 379
Query: 337 SISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLS-NSFTS--- 392
+ + + ++D +FQ L L L++ DN + I F+ L ++ + L+ N F
Sbjct: 380 NANKINCLRVD--AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCH 437
Query: 393 -------LRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQ 445
L T ET + SP + N +I +I+S F + G +
Sbjct: 438 LKWLADYLHTNPIETSGARCTSPRRLAN---KRIGQIKSKKFRCSAKEQYFIPGTEDYRS 494
Query: 446 ELTGQEW--------------------RGLENIFEIYLSYNKYLQLTRNSFALVPSLQRL 485
+L+G + + L I E Y L+L N F ++
Sbjct: 495 KLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVL------ 548
Query: 486 MLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARL 545
+ F+ L L ++ SNN I +I + EG + + L N L +
Sbjct: 549 -----------EATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENV 597
Query: 546 WKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASV 605
+H KGL L L L SN + + F L ++++ L N + T+
Sbjct: 598 -QHK-------MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGA 649
Query: 606 FNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETH 665
F+ SL +LNL NPF+C C +AW W+ +
Sbjct: 650 FDTLHSLSTLNLLA-------------------------NPFNCNC-YLAWLGEWLRKKR 683
Query: 666 --TNIPELSSHYLCNTPP 681
T P Y P
Sbjct: 684 IVTGNPRCQKPYFLKEIP 701
Score = 62.4 bits (150), Expect = 2e-09
Identities = 54/207 (26%), Positives = 78/207 (37%), Gaps = 38/207 (18%)
Query: 506 RNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLH 565
RN LDL+ NNI I GL L +L L N ++ + + A + L L
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGA--------FQDLKELE 106
Query: 566 ILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSV 625
L L N P +F +L +DL N + +P F V +K+L L N I+ +
Sbjct: 107 RLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCI 166
Query: 626 EKKVFGPAFR----------NLTELD--------------MRFNPFDCTCESIAWFVNWI 661
E F A R N+T L + N C C +AW +W+
Sbjct: 167 EDGAF-RALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCH-LAWLSDWL 224
Query: 662 NETHTNIPELSSHYLCNTPPHYHGFPV 688
+ P + + C P H G V
Sbjct: 225 RQR----PRVGLYTQCMGPSHLRGHNV 247
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/134 (29%), Positives = 58/134 (43%), Gaps = 1/134 (0%)
Query: 26 TKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFN 85
T+CT V CS+ L +P +P ++T L L NQ +P + Y LT +D+ N
Sbjct: 729 TECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVP-KELSNYKHLTLIDLSNN 787
Query: 86 TISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVK 145
IS L + + L L L +N L + +TF +L L L N I + F
Sbjct: 788 RISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFND 847
Query: 146 QKNLITLDLSHNGL 159
L L + N L
Sbjct: 848 LSALSHLAIGANPL 861
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 114 bits (286), Expect = 3e-25
Identities = 102/364 (28%), Positives = 162/364 (44%), Gaps = 20/364 (5%)
Query: 343 LPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFV 402
+ I F F L L L+++ N I + F L L+ L L N+ L+ L T
Sbjct: 71 ITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNL--LQALAPGTLA 128
Query: 403 SLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIY 462
L L IL N+IS++ +F L L L L N +G L + L N+ ++
Sbjct: 129 PLRK--LRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGA-LPDAVFAPLGNLLYLH 185
Query: 463 LSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANIN 522
L N+ L +N+FA + L+ L L L+ + F PLR+L+ L LS NN+ ++
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
Query: 523 DDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVF 582
+ + L +L +L L+ N L L A GL L L LE N ++P +
Sbjct: 246 PRIFQHLPRLGLLSLRGNQLTHLAPEA--------FWGLEALRELRLEGNRLSQLPTALL 297
Query: 583 KDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDM 642
+ L L+ +DL N L+ L + F + L+ L+L+ N ++++ +F A L LD+
Sbjct: 298 EPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFA-ASPALYRLDL 356
Query: 643 RFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFD-----TSSCK 697
N + C C + W+ + H+ L+ C PP G + D SC
Sbjct: 357 DGNGWTCDCR-LRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCA 415
Query: 698 DSAP 701
D +P
Sbjct: 416 DPSP 419
Score = 86.7 bits (213), Expect = 9e-17
Identities = 99/360 (27%), Positives = 156/360 (43%), Gaps = 43/360 (11%)
Query: 59 THNQLRRLP-AANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDK 117
T+ LR +P ++ + + +G N I+ + +L L+ L+LQ+N++ L K
Sbjct: 42 TNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPK 101
Query: 118 TFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELL 177
TF + L EL+L +N +Q + + L L + N +S G+ LE+L +L
Sbjct: 102 TFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLR 161
Query: 178 LSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSL 237
L N + AL N L L L SN+I+ F +G+L L L+ +L PSL
Sbjct: 162 LDGNALGALPDAVFAPLGN--LLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSL 219
Query: 238 TEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWL 297
TF L+ +L+ L LS NNL +G F L
Sbjct: 220 RHA-------------------------ATFAPLR--SLSSLILSANNLQHLGPRIFQHL 252
Query: 298 PQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCL 357
P+L L N + HL + GL +R L L+ + L+ LP + L L
Sbjct: 253 PRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGN------RLSQLPTA---LLEPLHSL 303
Query: 358 EHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKN 417
E L++ N++ + F L L+ LSL N+ +L L+ + F A L+ L+L N
Sbjct: 304 EALDLSGNELSALHPATFGHLGRLRELSLRNN--ALSALSGDIFA--ASPALYRLDLDGN 359
Score = 77.8 bits (190), Expect = 4e-14
Identities = 89/320 (27%), Positives = 129/320 (40%), Gaps = 41/320 (12%)
Query: 30 VSHEVADCSH----------LKLTQVPDDLPTNITVL--NLTHNQLRRLPAANFTRYSQL 77
V E DC H L++ LP+ VL +L N + + A +F R QL
Sbjct: 26 VCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQL 85
Query: 78 TSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQK 137
LD+ +N I L P+ +KL L+ L L +N L L+ T A L L+ N I +
Sbjct: 86 RRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISR 145
Query: 138 IKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQAL---------KS 188
+ F ++L+ L L N L + L NL L L +N+I+ L K
Sbjct: 146 LSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKL 205
Query: 189 EELDIFANS---------------SLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQL 233
L++ AN SL L LS+N ++ P F + RL L L QL
Sbjct: 206 RFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQL 265
Query: 234 GPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDS 293
E ++R L L ++LS L +L LDLS N L+ + +
Sbjct: 266 THLAPEAF---WGLEALRELRLEGNRLSQLPTALLEPLH--SLEALDLSGNELSALHPAT 320
Query: 294 FAWLPQLEYFFLEYNNIQHL 313
F L +L L N + L
Sbjct: 321 FGHLGRLRELSLRNNALSAL 340
Score = 73.6 bits (179), Expect = 8e-13
Identities = 70/220 (31%), Positives = 108/220 (49%), Gaps = 17/220 (7%)
Query: 56 LNLTHNQLRRL--PAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQ 113
LNL+ N+L+ AA F L+SL + N + L P + Q LP L +L+L+ N+L+
Sbjct: 208 LNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTH 267
Query: 114 LSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENL 173
L+ + F L EL L N + ++ +L LDLS N LS+ T L L
Sbjct: 268 LAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRL 327
Query: 174 QELLLSNNKIQALKSEELDIFANS-SLKKLELSSN---------QIKEFSPGCFHAIGRL 223
+EL L NN + AL DIFA S +L +L+L N +K + G +H+ GRL
Sbjct: 328 RELSLRNNALSALSG---DIFAASPALYRLDLDGNGWTCDCRLRGLKRWM-GDWHSQGRL 383
Query: 224 FGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTT 263
+F+ + P+L K L + ++N S ++ S +
Sbjct: 384 LTVFV-QCRHPPALRGKYLDYLDDQQLQNGSCADPSPSAS 422
Score = 53.9 bits (128), Expect = 7e-07
Identities = 36/104 (34%), Positives = 49/104 (47%)
Query: 55 VLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQL 114
+L+L NQL L F L L + N +S+L L + L L+ L+L NELS L
Sbjct: 257 LLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSAL 316
Query: 115 SDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNG 158
TF L EL L +N++ + + F L LDL NG
Sbjct: 317 HPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNG 360
Score = 38.9 bits (89), Expect = 0.022
Identities = 45/149 (30%), Positives = 59/149 (39%), Gaps = 13/149 (8%)
Query: 497 SSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIY 556
S PSP L L N I NI L +L LDLQ+N + L P
Sbjct: 54 SLPSPHDVLT----YSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL-------HPKT 102
Query: 557 FLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLN 616
F K LS L L L +N + L +L+I+ N ++ L F SL L
Sbjct: 103 FEK-LSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLR 161
Query: 617 LQKNLITSVEKKVFGPAFRNLTELDMRFN 645
L N + ++ VF P NL L + N
Sbjct: 162 LDGNALGALPDAVFAP-LGNLLYLHLESN 189
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 112 bits (281), Expect = 1e-24
Identities = 112/424 (26%), Positives = 182/424 (42%), Gaps = 53/424 (12%)
Query: 262 TTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGL 321
TT T G NLT + L D+F LP+LE + ++ +L ++ L
Sbjct: 62 TTLETRAFGSN-PNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL 120
Query: 322 FNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINL 381
S K +++ L + + FQ L LE L+++ N + + +F L +L
Sbjct: 121 ---------TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171
Query: 382 KYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLN 441
K L+L+ + L L E F L + L L L+ N +S + F LG L+
Sbjct: 172 KTLNLAQNL--LAQLPEELFHPL--TSLQTLKLSNNALSGLPQGVFGKLGSLQ------- 220
Query: 442 EIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSP 501
E++L N +L F+ + L+RL L+R A+ ++ S
Sbjct: 221 ------------------ELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSI-- 260
Query: 502 FQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGL 561
F L NLT L L N + + + L L L HN L + + L
Sbjct: 261 FASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGT--------FAHL 312
Query: 562 SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNL 621
S+L L L N +P +F+DL EL + LG NNL L ++F N L+ L+L KN
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
Query: 622 ITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPP 681
+T++ + +F + NL L + NP+ C C +A+ NW+ + + + ++ C P
Sbjct: 373 LTTLPEGIFDTNY-NLFNLALHGNPWQCDCH-LAYLFNWLQQYTDRLLNIQTY--CAGPA 428
Query: 682 HYHG 685
+ G
Sbjct: 429 YLKG 432
Score = 90.9 bits (224), Expect = 5e-18
Identities = 106/397 (26%), Positives = 158/397 (39%), Gaps = 34/397 (8%)
Query: 11 WGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAAN 70
W LL C + CS +L VP D+P + L
Sbjct: 9 WTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRA 68
Query: 71 FTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHL 130
F LT + + + P+ LP L+ L + + LS F+ T+L +L L
Sbjct: 69 FGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTL 128
Query: 131 MSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEE 190
N ++ + F L +L L N L + L +L+ L L+ N + L EE
Sbjct: 129 NFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQL-PEE 187
Query: 191 LDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFL--NNV-QLGPSLTEKL-CLE-- 244
L +SL+ L+LS+N + G F +G L LFL NN+ +L P + +L CLE
Sbjct: 188 L-FHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERL 246
Query: 245 -LANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM--------------LDLSYNNLNVV 289
L +I +L L S ++ N TFL L+W L + L L++N L V
Sbjct: 247 WLQRNAITHLPL--SIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
Query: 290 GNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDF 349
+FA L L L YN I HL + L K + +L +
Sbjct: 305 AEGTFAHLSNLRSLMLSYNAITHLPAGIFRDL---------EELVKLYLGSNNLTALHPA 355
Query: 350 SFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSL 386
FQ L LE L++ N + + +F NL L+L
Sbjct: 356 LFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLAL 392
Score = 60.8 bits (146), Expect = 5e-09
Identities = 46/150 (30%), Positives = 67/150 (44%), Gaps = 2/150 (1%)
Query: 58 LTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDK 117
L N + LP + F LT L + +N + L L P L L+L HN+L +++
Sbjct: 248 LQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEG 307
Query: 118 TFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELL 177
TFA +NL L L N+I + F + L+ L L N L++ L L+ L
Sbjct: 308 TFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLS 367
Query: 178 LSNNKIQALKSEELDIFANSSLKKLELSSN 207
LS N++ L D N +L L L N
Sbjct: 368 LSKNQLTTLPEGIFD--TNYNLFNLALHGN 395
Score = 50.1 bits (118), Expect = 9e-06
Identities = 30/86 (34%), Positives = 45/86 (52%)
Query: 51 TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNE 110
+N+ L L++N + LPA F +L L +G N ++ L P L Q L L++L+L N+
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
Query: 111 LSQLSDKTFAFCTNLTELHLMSNSIQ 136
L+ L + F NL L L N Q
Sbjct: 373 LTTLPEGIFDTNYNLFNLALHGNPWQ 398
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 109 bits (273), Expect = 1e-23
Identities = 118/463 (25%), Positives = 199/463 (42%), Gaps = 73/463 (15%)
Query: 22 ASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLD 81
A CT + + DC L +P DLP+ LNL++N+L + A F
Sbjct: 39 APCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGF---------- 88
Query: 82 VGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNN 141
+ LP L+ + L +NEL+ + A +++ L L N I+ ++ +
Sbjct: 89 --------------EDLPNLQEVYLNNNELTAVPSLGAA-SSHVVSLFLQHNKIRSVEGS 133
Query: 142 PFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKK 201
+L LDLS N ++ + ++EL L+ N+I L+ D + S L
Sbjct: 134 QLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLT- 192
Query: 202 LELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLS 261
L LS N+I + F P LT+ L L+ +++
Sbjct: 193 LRLSKNRITQLPVRAFKL---------------PRLTQ-------------LDLNRNRIR 224
Query: 262 TTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGL 321
TF GL +L +L L NN++ + + +F L ++ LEYN++ + S SL+GL
Sbjct: 225 LIEGLTFQGLN--SLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGL 282
Query: 322 FNVRYLNLKR-----------SFTKQS----ISLASLPKIDDFSFQWLKCLEHLNMEDND 366
+ L+L SF ++ +S +L ++D+ S L L L + N
Sbjct: 283 TALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNS 342
Query: 367 IPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDA 426
I I F GL +L+ L L ++ S T+ + + L L L NKI + A
Sbjct: 343 ISHIAEGAFKGLRSLRVLDLDHNEIS-GTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRA 401
Query: 427 FSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYL 469
FS L LE L+LG N I + + + ++N+ E+++S + +L
Sbjct: 402 FSGLEGLEHLNLGGNAI-RSVQFDAFVKMKNLKELHISSDSFL 443
Score = 92.8 bits (229), Expect = 1e-18
Identities = 86/316 (27%), Positives = 145/316 (45%), Gaps = 17/316 (5%)
Query: 337 SISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTL 396
++S L +ID F+ L L+ + + +N++ + S G + +SL +R++
Sbjct: 74 NLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPS---LGAASSHVVSLFLQHNKIRSV 130
Query: 397 TNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLE 456
A+ L +L+L+ N I+++ + F ++ L+L N IG G
Sbjct: 131 EGSQLK--AYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSR 188
Query: 457 NIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNN 516
++ + LS N+ QL +F L P L +L L R ++ ++ FQ L +L +L L N
Sbjct: 189 SLLTLRLSKNRITQLPVRAFKL-PRLTQLDLNRNRIRLIEGLT--FQGLNSLEVLKLQRN 245
Query: 517 NIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDE 576
NI+ + D GL K+ +L L++N+L + N G L GL+ LH L+L +N
Sbjct: 246 NISKLTDGAFWGLSKMHVLHLEYNSLVEV----NSGS----LYGLTALHQLHLSNNSIAR 297
Query: 577 IPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRN 636
I + + +L + L NNL L SL L L N I+ + + F R+
Sbjct: 298 IHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAF-KGLRS 356
Query: 637 LTELDMRFNPFDCTCE 652
L LD+ N T E
Sbjct: 357 LRVLDLDHNEISGTIE 372
Score = 43.9 bits (102), Expect = 7e-04
Identities = 36/135 (26%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 511 LDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLE 570
L+LS N ++ I+ E L L+ + L +N L + SH+ L L+
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS---------SHVVSLFLQ 123
Query: 571 SNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVF 630
N + K L+++DL LNN+ + + F + +K LNL N I ++E F
Sbjct: 124 HNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAF 183
Query: 631 GPAFRNLTELDMRFN 645
R+L L + N
Sbjct: 184 DGLSRSLLTLRLSKN 198
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 108 bits (269), Expect = 3e-23
Identities = 112/459 (24%), Positives = 199/459 (43%), Gaps = 75/459 (16%)
Query: 26 TKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFN 85
T C ++ DCS +L ++P+ LP+ + L+L+HN+L + A++ +
Sbjct: 49 TTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSH------------ 96
Query: 86 TISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVK 145
L L+ + L +NEL + + N+T L L N I +I +
Sbjct: 97 ------------LQSLREVKLNNNELETIPN-LGPVSANITLLSLAGNRIVEILPEHLKE 143
Query: 146 QKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELS 205
++L TLDLS N +S +L T L+ L L++N++ +++ D AN +L L+L+
Sbjct: 144 FQSLETLDLSSNNIS--ELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLAN-TLLVLKLN 200
Query: 206 SNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSN 265
N+I P F +++L L+ +++
Sbjct: 201 RNRISAIPPKMFKL----------------------------PQLQHLELNRNKIKNVDG 232
Query: 266 TTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVR 325
TF GL L L + N + + + +F L +E L++NN+ + L+GL ++
Sbjct: 233 LTFQGL--GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ 290
Query: 326 YLNLKRS---------------FTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGI 370
L+L ++ ++ ++ L ++DD SF L L L++ +N + I
Sbjct: 291 ELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYI 350
Query: 371 KSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWL 430
F GL +LK L L N+ S T+ + L L L N+I I AF+ L
Sbjct: 351 ADCAFRGLSSLKTLDLKNNEISW-TIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGL 409
Query: 431 GHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYL 469
LE LDL N I L G + ++ + +++L+ + L
Sbjct: 410 DALEHLDLSDNAI-MSLQGNAFSQMKKLQQLHLNTSSLL 447
Score = 99.0 bits (245), Expect = 2e-20
Identities = 108/416 (25%), Positives = 184/416 (44%), Gaps = 54/416 (12%)
Query: 152 LDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKE 211
LDLSHN LS K + L++L+E+ L+NN+++ + + + AN +L L L+ N+I E
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG-PVSANITL--LSLAGNRIVE 135
Query: 212 FSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGL 271
P L L L++ + T L+L + L L+++++++ F L
Sbjct: 136 ILPEHLKEFQSLETLDLSSNNISELQTAFPALQL-----KYLYLNSNRVTSMEPGYFDNL 190
Query: 272 KWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKR 331
T L +L L+ N ++ + F LPQL++ L N I++
Sbjct: 191 ANT-LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKN------------------- 229
Query: 332 SFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFT 391
+D +FQ L L+ L M+ N + + F GL N++ L L ++
Sbjct: 230 --------------VDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHN-- 273
Query: 392 SLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQE 451
+L +T L L L+L++N I++I DA+ + L LDL N + + L
Sbjct: 274 NLTEITKGWLYGLLM--LQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR-LDDSS 330
Query: 452 WRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALK-NVDSSPSPFQPLRNLTI 510
+ GL + +++ N+ + +F + SL+ L L+ + ++ F L L
Sbjct: 331 FLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRR 390
Query: 511 LDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHI 566
L L N I +I GL+ LE LDL N + L G +K L LH+
Sbjct: 391 LILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL-----QGNAFSQMKKLQQLHL 441
Score = 87.0 bits (214), Expect = 7e-17
Identities = 88/319 (27%), Positives = 141/319 (44%), Gaps = 43/319 (13%)
Query: 360 LNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKI 419
L++ N + IK++ + L +L+ + L+N+ L T+ N VS + + +L+L N+I
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNN--ELETIPNLGPVS---ANITLLSLAGNRI 133
Query: 420 SKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKY----------- 468
+I + LE LDL N I + T L+ + YL+ N+
Sbjct: 134 VEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYL---YLNSNRVTSMEPGYFDNL 190
Query: 469 ------LQLTRNSFALVP-------SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN 515
L+L RN + +P LQ L L R +KNVD FQ L L L +
Sbjct: 191 ANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT--FQGLGALKSLKMQR 248
Query: 516 NNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFD 575
N + + D GL +EIL L HNNL + K +L GL L L+L N +
Sbjct: 249 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKG--------WLYGLLMLQELHLSQNAIN 300
Query: 576 EIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFR 635
I + ++ +L +DL N+L+ L S F L +L++ N ++ + F
Sbjct: 301 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAF-RGLS 359
Query: 636 NLTELDMRFNPFDCTCESI 654
+L LD++ N T E +
Sbjct: 360 SLKTLDLKNNEISWTIEDM 378
Score = 82.4 bits (202), Expect = 2e-15
Identities = 82/322 (25%), Positives = 134/322 (41%), Gaps = 17/322 (5%)
Query: 31 SHEVADCSHLKLTQVPDDLPT-NITVLNLTHNQLRRLPAANFTRYSQ-LTSLDVGFNTIS 88
S E D S ++++ P + L L N++ + F + L L + N IS
Sbjct: 146 SLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 205
Query: 89 KLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKN 148
+ P++ KLP L+ L L N++ + TF L L + N + K+ + F N
Sbjct: 206 AIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 264
Query: 149 LITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQ 208
+ L L HN L+ G L LQEL LS N I + + + L +L+L+ N
Sbjct: 265 MEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC--QKLSELDLTFNH 322
Query: 209 IKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKL--CLELANTSIRNLSLSNSQLSTT--- 263
+ F + LN + +G + + C +S++ L L N+++S T
Sbjct: 323 LSRLDDSSFLGLS-----LLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIED 377
Query: 264 SNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFN 323
N F GL L L L N + + +F L LE+ L N I L ++ +
Sbjct: 378 MNGAFSGL--DKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK 435
Query: 324 VRYLNLKRSFTKQSISLASLPK 345
++ L+L S L LP+
Sbjct: 436 LQQLHLNTSSLLCDCQLKWLPQ 457
Score = 74.7 bits (182), Expect = 4e-13
Identities = 69/265 (26%), Positives = 121/265 (45%), Gaps = 16/265 (6%)
Query: 56 LNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLS 115
L L N+++ + F L SL + N ++KL L +++L L HN L++++
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
Query: 116 DKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQE 175
L ELHL N+I +I + + + L LDL+ N LS + + L L
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNT 339
Query: 176 LLLSNNKIQALKSEELDIFANSSLKKLELSSNQIK---EFSPGCFHAIGRLFGLFLNNVQ 232
L + NN++ + + SSLK L+L +N+I E G F + +L L L +
Sbjct: 340 LHIGNNRVSYI--ADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNR 397
Query: 233 LGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGND 292
+ S+T+K L ++ +L LS++ + + F +K + L N +++ +
Sbjct: 398 I-RSITKKAFTGL--DALEHLDLSDNAIMSLQGNAFSQMK----KLQQLHLNTSSLLCDC 450
Query: 293 SFAWLPQLEYFFLEYNNIQHLFSHS 317
WLPQ ++ NN Q + S
Sbjct: 451 QLKWLPQ----WVAENNFQSFVNAS 471
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 107 bits (266), Expect = 7e-23
Identities = 157/620 (25%), Positives = 270/620 (43%), Gaps = 62/620 (10%)
Query: 34 VADCSHLKLTQVPDDLPT--NITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLE 91
+ + SH ++ +P ++ NI L +N + P+ + L L +G N + +
Sbjct: 215 ILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPS-DLECLGNLEILSLGKNKLRHI- 272
Query: 92 PELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLIT 151
P+ L L+VLNL++N+L+ K F L L L N I + + KNL T
Sbjct: 273 PDTLPSLKTLRVLNLEYNQLTTFP-KALCFLPKLISLDLTGNLISSLPKE-IRELKNLET 330
Query: 152 LDLSHNGLSSTKLGTQV-QLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIK 210
L + HN L T L ++ QL ++EL L++NK++ + S +++ F L+ L L N +K
Sbjct: 331 LLMDHNKL--TFLAVEIFQLLKIKELQLADNKLEVI-SHKIENFRE--LRILILDKNLLK 385
Query: 211 EFSPGCFHAIGRLFGLFLNNVQLG--PSLTEKLCLELANTSIRNLSLS-NSQLSTTSNTT 267
P L L L++ +L P KL ++R L ++ N+ + T +
Sbjct: 386 NI-PEKISCCAMLECLSLSDNKLTELPKYIHKL------NNLRKLHVNRNNMVKITDCIS 438
Query: 268 FLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYL 327
L N+ L+ S N + V + ++ L YN I + F L L ++ YL
Sbjct: 439 HLN----NICSLEFSGNIITDVPIE-IKNCQKIIKIELSYNKIMY-FPLGLCALDSLYYL 492
Query: 328 NLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLS 387
++ ++ ++ +P FS Q L HL + +N + I S F LINLKYL L
Sbjct: 493 SVNGNY------ISEIPVDISFSKQLL----HLELSENKLL-IFSEHFCSLINLKYLDLG 541
Query: 388 NSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQEL 447
+ + +SL H+L L NK + + L +L+VLDL N++ +
Sbjct: 542 KNQIKKIPASISNMISL-----HVLILCCNKFETFPRELCT-LENLQVLDLSENQL--QK 593
Query: 448 TGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRN 507
+ L+ I ++ S N+++ L SL++L + ++ + + P +
Sbjct: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQL-QSLEQLNISQIKGRKLTRLPGELSNMTQ 652
Query: 508 LTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHIL 567
L LD+SNN I I ++ E L L L +N ++ L L L+ L L
Sbjct: 653 LKELDISNNAIREIPRNIGE-LRNLVSLHAYNNQISYLPPS---------LLSLNDLQQL 702
Query: 568 NLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQ---VSLKSLNLQKNLITS 624
NL N +P ++ ++F LK I+ N L P + + + L
Sbjct: 703 NLSGNNLTALPSAIY-NIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEK 761
Query: 625 VEKKVFGPAFRNLTELDMRF 644
+ +K+F N+TE + F
Sbjct: 762 ILEKIFKIVANNITETNFEF 781
Score = 65.9 bits (159), Expect = 2e-10
Identities = 134/541 (24%), Positives = 220/541 (40%), Gaps = 117/541 (21%)
Query: 154 LSHNGLSSTKLGTQVQLENLQELLLS------NNKIQALKSEELDIFANSSLKKLELSSN 207
LSH + ++ QV EN ++L L N + + L+ DI +K L L N
Sbjct: 117 LSHETVG--EVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKN 174
Query: 208 QIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLS-TTSNT 266
QIK F G L GL + ++Q + ++L + ++R L++S++ +S
Sbjct: 175 QIKTFQGA---DSGDLLGLEILSLQENGLSSLPSEIQLLH-NLRILNVSHNHISHIPKEI 230
Query: 267 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRY 326
+ LG N+ L YNN L LE L N ++H+ +L L +R
Sbjct: 231 SQLG----NIRQL-FFYNNYIENFPSDLECLGNLEILSLGKNKLRHI-PDTLPSLKTLRV 284
Query: 327 LNLKRS----------FTKQSISL-------ASLPKIDDFSFQWLKCLEHLNMEDNDIPG 369
LNL+ + F + ISL +SLPK + LK LE L M+ N +
Sbjct: 285 LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPK----EIRELKNLETLLMDHNKLTF 340
Query: 370 IKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSW 429
+ +F L+ +K L L+++ + + E F L IL L KN + I + S
Sbjct: 341 LAVEIFQ-LLKIKELQLADNKLEVISHKIENF-----RELRILILDKNLLKNIP-EKISC 393
Query: 430 LGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRR 489
LE L L N++ + KY+ N L++L + R
Sbjct: 394 CAMLECLSLSDNKLTE-------------------LPKYIHKLNN-------LRKLHVNR 427
Query: 490 VALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHA 549
N+ L N+ L+ S N I ++ + ++ +K+ ++L +N +
Sbjct: 428 ---NNMVKITDCISHLNNICSLEFSGNIITDVPIE-IKNCQKIIKIELSYNKI------- 476
Query: 550 NPGGPIYFLKGL---SHLHILNLESNGFDEIPVEV----------------------FKD 584
+YF GL L+ L++ N EIPV++ F
Sbjct: 477 -----MYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCS 531
Query: 585 LFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRF 644
L LK +DLG N + +PAS+ +N +SL L L N + +++ NL LD+
Sbjct: 532 LINLKYLDLGKNQIKKIPASI-SNMISLHVLILCCNKFETFPRELC--TLENLQVLDLSE 588
Query: 645 N 645
N
Sbjct: 589 N 589
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 105 bits (262), Expect = 2e-22
Identities = 121/472 (25%), Positives = 202/472 (42%), Gaps = 53/472 (11%)
Query: 215 GC-FHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 273
GC + RL + + L P+ LC + I L S +L S GL
Sbjct: 15 GCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLP 74
Query: 274 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRS- 332
+ +LD S+N L+ W LE L+ + + + L + Y S
Sbjct: 75 PDTAILDFSHNRLS-------NWNISLESQTLQEVKMNY------NELTEIPYFGEPTSN 121
Query: 333 FTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTS 392
T S+ +P+I+ + Q+ LE L++ N I IK++ F + LKYL+LSN+
Sbjct: 122 ITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNN--R 178
Query: 393 LRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIG-------- 444
+ TL F +L+ S L ++ L +N++S I F L HL+ L+L N I
Sbjct: 179 ITTLEAGCFDNLS-SSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQ 236
Query: 445 ---------------QELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRR 489
+L + GL N+ E+ L +N ++ + + LQ+L + +
Sbjct: 237 GLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQ 296
Query: 490 VALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHA 549
A++ + SP ++ + L+ LDLS N + +++ GL LE L+L N + +
Sbjct: 297 NAIERI--SPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHI---- 350
Query: 550 NPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQ 609
G FL L L + N E + E E F L L + L N + ++ F
Sbjct: 351 -ADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGL 409
Query: 610 VSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWI 661
SL+ L+L N I S+++ F +L EL + + C C + W + W+
Sbjct: 410 ESLEHLDLNNNAIMSIQENAFSQT--HLKELILNTSSLLCDCH-LKWLLQWL 458
Score = 98.2 bits (243), Expect = 3e-20
Identities = 113/424 (26%), Positives = 184/424 (43%), Gaps = 56/424 (13%)
Query: 28 CTVSHEVADCSHLKLTQ-----VPDDLPTNITVLNLTHNQLRRLPAANFTRYSQ-LTSLD 81
C+ + DCS KL + LP + +L+ +HN RL N + SQ L +
Sbjct: 47 CSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHN---RLSNWNISLESQTLQEVK 103
Query: 82 VGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNN 141
+ +N ++++ P + + +L+L HN + +++ + F L L L SN I +IK +
Sbjct: 104 MNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTS 162
Query: 142 PFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKK 201
F + + L+ L LSNN+I L++ D + SSL
Sbjct: 163 SFPRMQ-------------------------LKYLNLSNNRITTLEAGCFDNLS-SSLLV 196
Query: 202 LELSSNQIKEFSPGCFHAIGRLF-GLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQL 260
++L+ N++ P F F L N +++ LT + S+R+L + + +
Sbjct: 197 VKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQ-----GLDSLRSLKMQRNGI 251
Query: 261 STTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHG 320
S + F GL N+ L+L +NNL V L L+ ++ N I+ + +
Sbjct: 252 SKLKDGAFFGLN--NMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEF 309
Query: 321 LFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLIN 380
+ L+L S L ++D+ +F L LE LN+ DN + I +F L N
Sbjct: 310 CQRLSELDL---------SYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN 360
Query: 381 LKYLSLSNSFTSLRTL-TNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLG 439
L+ L L N+ S +E F L + L L L N+I I AF L LE LDL
Sbjct: 361 LQTLDLRNNEISWAIEDASEAFAGL--TSLTKLILQGNQIKSITKKAFIGLESLEHLDLN 418
Query: 440 LNEI 443
N I
Sbjct: 419 NNAI 422
Score = 92.0 bits (227), Expect = 2e-18
Identities = 99/401 (24%), Positives = 176/401 (43%), Gaps = 54/401 (13%)
Query: 152 LDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN--SSLKKLELSSNQI 209
LD SHN LS+ + + Q LQE+ ++ N++ E+ F S++ L L N I
Sbjct: 80 LDFSHNRLSNWNISLESQ--TLQEVKMNYNELT-----EIPYFGEPTSNITLLSLVHNII 132
Query: 210 KEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFL 269
E + L L L++ + T ++ L+LSN++++T F
Sbjct: 133 PEINAQALQFYPALESLDLSSNIISEIKTSSF----PRMQLKYLNLSNNRITTLEAGCFD 188
Query: 270 GLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNL 329
L ++L ++ L+ N ++++ F LP L++ L+ N I+ + + GL ++R L +
Sbjct: 189 NLS-SSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKM 246
Query: 330 KRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNS 389
+R+ + K+ D +F L +E L +E N++ + GL L+ L +S
Sbjct: 247 QRN---------GISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVS-- 295
Query: 390 FTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTG 449
+N I +I DA+ + L LDL N++ + L
Sbjct: 296 --------------------------QNAIERISPDAWEFCQRLSELDLSYNQLTR-LDE 328
Query: 450 QEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALK-NVDSSPSPFQPLRNL 508
+ GL + + L N+ + F + +LQ L LR + ++ + F L +L
Sbjct: 329 SAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSL 388
Query: 509 TILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHA 549
T L L N I +I GLE LE LDL +N + + ++A
Sbjct: 389 TKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENA 429
Score = 91.7 bits (226), Expect = 3e-18
Identities = 95/355 (26%), Positives = 164/355 (46%), Gaps = 25/355 (7%)
Query: 41 KLTQVP--DDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKL 98
+LT++P + +NIT+L+L HN + + A Y L SLD+ N IS+++ ++
Sbjct: 108 ELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM 167
Query: 99 PMLKVLNLQHNELSQLSDKTF-AFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHN 157
LK LNL +N ++ L F ++L + L N + I F K +L L+L N
Sbjct: 168 -QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIF-KLPHLQFLELKRN 225
Query: 158 GLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCF 217
+ + T L++L+ L + N I LK F +++++LEL N + + G
Sbjct: 226 RIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGA--FFGLNNMEELELEHNNLTRVNKGWL 283
Query: 218 HAIGRLFGLFLNN---VQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWT 274
+ + L L+++ ++ P E C L+ L LS +QL+ + F+GL +
Sbjct: 284 YGLRMLQQLYVSQNAIERISPDAWE-FCQRLS-----ELDLSYNQLTRLDESAFVGL--S 335
Query: 275 NLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFT 334
L L+L N + + + F +L L+ L N I + + S T
Sbjct: 336 LLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGL------TSLT 389
Query: 335 KQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNS 389
K + + I +F L+ LEHL++ +N I I+ N F+ +LK L L+ S
Sbjct: 390 KLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFS-QTHLKELILNTS 443
Score = 73.9 bits (180), Expect = 6e-13
Identities = 62/219 (28%), Positives = 102/219 (46%), Gaps = 6/219 (2%)
Query: 56 LNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLS 115
L + N + +L F + + L++ N ++++ L ML+ L + N + ++S
Sbjct: 244 LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303
Query: 116 DKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQE 175
+ FC L+EL L N + ++ + FV L L+L N ++ G L NLQ
Sbjct: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQT 363
Query: 176 LLLSNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLG 234
L L NN+I + + FA +SL KL L NQIK + F + L L LNN +
Sbjct: 364 LDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAI- 422
Query: 235 PSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 273
S+ E + T ++ L L+ S L + +L L+W
Sbjct: 423 MSIQEN---AFSQTHLKELILNTSSLLCDCHLKWL-LQW 457
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 101 bits (251), Expect = 4e-21
Identities = 114/444 (25%), Positives = 187/444 (42%), Gaps = 83/444 (18%)
Query: 297 LPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKC 356
LP L F + + L + G +V L R +++ L+S+PK + +
Sbjct: 8 LPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPK------NFPES 61
Query: 357 LEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTK 416
L + N+I I + TGL +L L L NS ++ + + FV L H L+ L L
Sbjct: 62 TVFLYLTGNNISYINESELTGLHSLVALYLDNS--NILYVYPKAFVQLRH--LYFLFLNN 117
Query: 417 NKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSF 476
N I +++ F +GL N+ +YL YN+ + R F
Sbjct: 118 NFIKRLDPGIF-------------------------KGLLNLRNLYLQYNQVSFVPRGVF 152
Query: 477 ALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILD 536
+ S+Q L L+R L + S F + L ILDLSNNNI I++ + LE L L
Sbjct: 153 NDLVSVQYLNLQRNRLTVLGSGT--FVGMVALRILDLSNNNILRISESGFQHLENLACLY 210
Query: 537 LQHNNLARLWKHA--------------NPGGPI--YFLKGLSHLHILNLESNGFDEIPVE 580
L NNL ++ +A NP I + KGL++L L L+++ + +
Sbjct: 211 LGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD 270
Query: 581 VFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEK----------KVF 630
F + LK + L N+L L + F+ +L L L +N I S++ K+
Sbjct: 271 GFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKIL 330
Query: 631 GPAFRNLTELDMRF--------------NPFDCTCESIAWFVNWINETHTNIPELSSHYL 676
+F NLT L R NP++C C+ + +W+ + ++ +
Sbjct: 331 NLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLG-LRDWLASS-----AITLNIY 384
Query: 677 CNTPPHYHGFPVRLFDTSSCKDSA 700
C PP G +R + ++C S+
Sbjct: 385 CQNPPSMRGRALRYINITNCVTSS 408
Score = 87.4 bits (215), Expect = 5e-17
Identities = 96/398 (24%), Positives = 167/398 (41%), Gaps = 48/398 (12%)
Query: 21 CASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSL 80
C+S CT +C +L L+ +P + P + L LT N + + + T L +L
Sbjct: 32 CSSVCQLCTGRQ--INCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVAL 89
Query: 81 DV------------------------GFNTISKLEPELCQKLPMLKVLNLQHNELSQLSD 116
+ N I +L+P + + L L+ L LQ+N++S +
Sbjct: 90 YLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPR 149
Query: 117 KTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQEL 176
F ++ L+L N + + + FV L LDLS+N + LENL L
Sbjct: 150 GVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACL 209
Query: 177 LLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPS 236
L +N + + S ++ SL++L LS N I+ P F + L L L N ++
Sbjct: 210 YLGSNNLTKVPSNAFEVL--KSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNV 267
Query: 237 LTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAW 296
+ ++++L LS++ L ++ TF LK NL L L N + + ND+F
Sbjct: 268 TRDGFS---GINNLKHLILSHNDLENLNSDTFSLLK--NLIYLKLDRNRIISIDNDTFEN 322
Query: 297 L-PQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWL- 354
+ L+ L +NN+ L L L ++ +L + + + L L WL
Sbjct: 323 MGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLR-------DWLA 375
Query: 355 KCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTS 392
LN+ + P ++ L+Y++++N TS
Sbjct: 376 SSAITLNIYCQNPPSMRGRA------LRYINITNCVTS 407
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 101 bits (251), Expect = 4e-21
Identities = 89/344 (25%), Positives = 148/344 (43%), Gaps = 22/344 (6%)
Query: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
+CTV C+ +LT VPD +P +L L+ N++R L + L LD+ N
Sbjct: 30 ECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENA 89
Query: 87 ISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQ 146
I+ +EP LP L+VL L+ N+L + F NLT L L N + + + F
Sbjct: 90 IAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDL 149
Query: 147 KNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSS---LKKLE 203
+L L++ N L L L+EL L + AL E L + L+ L
Sbjct: 150 HSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLA 209
Query: 204 LSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTT 263
++S + + F RL GL + P L E L ++ +LS++++ ++
Sbjct: 210 IASLEDQNFR--------RLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAV 261
Query: 264 SNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFN 323
+LT L+LS+N ++ V SF L +L L + + + GL
Sbjct: 262 PAAAL--RHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQ 319
Query: 324 VRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI 367
+R LNL + L +++ +F + LE L ++ N +
Sbjct: 320 IRLLNLSNNL---------LSTLEESTFHSVNTLETLRVDGNPL 354
Score = 81.3 bits (199), Expect = 4e-15
Identities = 90/353 (25%), Positives = 152/353 (43%), Gaps = 28/353 (7%)
Query: 354 LKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILN 413
L LE L++ +N I ++ F L L+ L L + L+ + F L + L +L+
Sbjct: 77 LPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGN--QLKLIPPGVFTRLDN--LTLLD 132
Query: 414 LTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTR 473
L++NK+ + F L L L++G N++ ++ + + GL + E+ L L+
Sbjct: 133 LSENKLVILLDYTFQDLHSLRRLEVGDNDL-VFVSRRAFAGLLALEELTLERCNLTALSG 191
Query: 474 NSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN-NNIANINDDMLEGLEKL 532
S + SL L LR +A+ +++ F+ L L L++ N + + L GL L
Sbjct: 192 ESLGHLRSLGALRLRHLAIASLEDQN--FRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-L 248
Query: 533 EILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIID 592
L + H N+ + P L+ +HL LNL N +P F+DL L+ +
Sbjct: 249 TSLSVTHTNITAV--------PAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELH 300
Query: 593 LGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCE 652
L L + F ++ LNL NL++++E+ F + L L + NP C C
Sbjct: 301 LAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTF-HSVNTLETLRVDGNPLACDCR 359
Query: 653 SIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELF 705
+ WI + + C TP G +R + DS FE F
Sbjct: 360 LL-----WIVQRRKTLNFDGRLPACATPAEVRGDALR-----NLPDSVLFEYF 402
Score = 70.5 bits (171), Expect = 7e-12
Identities = 81/305 (26%), Positives = 130/305 (42%), Gaps = 46/305 (15%)
Query: 278 MLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRS----- 332
+L+LS N + + A LP LE L N I H+ + L +R L L+ +
Sbjct: 58 LLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLI 117
Query: 333 ----FTK-QSISLASLPK-----IDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLK 382
FT+ +++L L + + D++FQ L L L + DND+ + F GL+ L+
Sbjct: 118 PPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALE 177
Query: 383 YLSLSNSFTSLRTLTNETFVSLAH-SPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLN 441
L+L +L L+ E SL H L L L I+ +E F L L L++
Sbjct: 178 ELTLER--CNLTALSGE---SLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNW 232
Query: 442 EIGQELTGQEWRGLE-----------------------NIFEIYLSYNKYLQLTRNSFAL 478
+ +E+ RGL ++ + LS+N + R SF
Sbjct: 233 PLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRD 292
Query: 479 VPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQ 538
+ L+ L L L V+ P F LR + +L+LSNN ++ + + + LE L +
Sbjct: 293 LVRLRELHLAGALLAVVE--PQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVD 350
Query: 539 HNNLA 543
N LA
Sbjct: 351 GNPLA 355
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 100 bits (249), Expect = 6e-21
Identities = 87/341 (25%), Positives = 154/341 (45%), Gaps = 16/341 (4%)
Query: 27 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 86
+C+ ++ C +L +P+ +P +L+L+ N+L+ + F Y L +D+ N
Sbjct: 33 ECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNI 92
Query: 87 ISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQ 146
I+ +EP L L+ L L+ N L + F +NLT+L + N I + + F
Sbjct: 93 IANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDL 152
Query: 147 KNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSS 206
NL +L++ N L L +L++L L + A+ +E L SL L L
Sbjct: 153 HNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHL--RSLISLHLKH 210
Query: 207 NQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT 266
I +A RLF L + P L L ++ +LS++N+ LST
Sbjct: 211 LNINNMP---VYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFL 267
Query: 267 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRY 326
F L + LT L+LSYN ++ + F+ L +L+ + ++ + HS GL +R
Sbjct: 268 AFKHLVY--LTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325
Query: 327 LNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI 367
LN+ ++ L +++ F + LE L++ +N +
Sbjct: 326 LNVSQNL---------LETLEENVFSSPRALEVLSINNNPL 357
Score = 84.7 bits (208), Expect = 3e-16
Identities = 85/302 (28%), Positives = 136/302 (45%), Gaps = 40/302 (13%)
Query: 278 MLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQS 337
+LDLS N L V + F P LE L N I ++ + + LFN+R L LK + K
Sbjct: 61 ILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLV 120
Query: 338 -----ISLASLPKID----------DFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLK 382
L++L K+D D+ FQ L L+ L + DND+ I F+GL++L+
Sbjct: 121 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLE 180
Query: 383 YLSLSN-SFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEV-----L 436
L+L + T++ T SL LH+ +L N + L HLE+ L
Sbjct: 181 QLTLEKCNLTAVPTEALSHLRSLI--SLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLL 238
Query: 437 DL-------GLNEIGQELTGQE--------WRGLENIFEIYLSYNKYLQLTRNSFALVPS 481
D+ GLN +T ++ L + + LSYN + F+ +
Sbjct: 239 DMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIR 298
Query: 482 LQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNN 541
LQ L + L+ ++ P FQ LR L +L++S N + + +++ LE+L + +N
Sbjct: 299 LQELHIVGAQLRTIE--PHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNP 356
Query: 542 LA 543
LA
Sbjct: 357 LA 358
Score = 71.2 bits (173), Expect = 4e-12
Identities = 79/322 (24%), Positives = 148/322 (45%), Gaps = 19/322 (5%)
Query: 338 ISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLT 397
+S L ++ F LE +++ DN I ++ F L NL+ L L + L+ +
Sbjct: 64 LSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGN--RLKLVP 121
Query: 398 NETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLEN 457
F L++ L L++++NKI + F L +L+ L++G N++ ++ + + GL +
Sbjct: 122 LGVFTGLSN--LTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVY-ISHRAFSGLLS 178
Query: 458 IFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNN 517
+ ++ L + + + + SL L L+ + + N+ F+ L +L L++
Sbjct: 179 LEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYA--FKRLFHLKHLEIDYWP 236
Query: 518 IANIND-DMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDE 576
+ ++ + L GL L L + + NL+ + P K L +L LNL N
Sbjct: 237 LLDMMPANSLYGLN-LTSLSVTNTNLSTV--------PFLAFKHLVYLTHLNLSYNPIST 287
Query: 577 IPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRN 636
I +F DL L+ + + L T+ F L+ LN+ +NL+ ++E+ VF R
Sbjct: 288 IEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSP-RA 346
Query: 637 LTELDMRFNPFDCTCESIAWFV 658
L L + NP C C + W +
Sbjct: 347 LEVLSINNNPLACDCR-LLWIL 367
Score = 48.5 bits (114), Expect = 3e-05
Identities = 41/154 (26%), Positives = 70/154 (45%), Gaps = 25/154 (16%)
Query: 510 ILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGG---------------- 553
ILDLS N + ++N + LE +DL N +A + PG
Sbjct: 61 ILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIA----NVEPGAFNNLFNLRSLRLKGNR 116
Query: 554 ----PIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQ 609
P+ GLS+L L++ N + +F+DL LK +++G N+L + F+
Sbjct: 117 LKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGL 176
Query: 610 VSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMR 643
+SL+ L L+K +T+V + R+L L ++
Sbjct: 177 LSLEQLTLEKCNLTAVPTEALS-HLRSLISLHLK 209
Score = 38.1 bits (87), Expect = 0.037
Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 1/80 (1%)
Query: 566 ILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSV 625
IL+L N + E F L+ IDL N + + FNN +L+SL L+ N + V
Sbjct: 61 ILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLV 120
Query: 626 EKKVFGPAFRNLTELDMRFN 645
VF NLT+LD+ N
Sbjct: 121 PLGVF-TGLSNLTKLDISEN 139
Score = 33.1 bits (74), Expect = 1.2
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 587 ELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFN 645
E KI+DL N L ++ F + L+ ++L N+I +VE F F NL L ++ N
Sbjct: 58 ETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLF-NLRSLRLKGN 115
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 99.8 bits (247), Expect = 1e-20
Identities = 115/440 (26%), Positives = 191/440 (43%), Gaps = 43/440 (9%)
Query: 269 LGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLN 328
LGL TNLT + L V+ + SF+ + L+ + ++I + + L ++ L
Sbjct: 46 LGLP-TNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLR 104
Query: 329 LKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSN 388
L R+ + + + LE L ++ N + GI NMF L+NL+ L+L+
Sbjct: 105 LSRN---------KITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQ 155
Query: 389 SFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELT 448
+ L L F +L + L +L+L+ N ++ + LE L L N + L
Sbjct: 156 N--QLDFLPASLFTNLEN--LKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL-VSLD 210
Query: 449 GQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNL 508
L + E+ N + +F +P+L L L R L + S+ F NL
Sbjct: 211 SGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSAL--FLHSHNL 268
Query: 509 TILDLSNNNIANINDDM---LEGLEKLEILDLQ--------HNNLARLWK---------H 548
T+L L N +A + + + GL++L + Q NL+RL
Sbjct: 269 TLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLS 328
Query: 549 ANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNN 608
A P G +GL L +L L SNG +P + + L +L+ + L N L LP ++F N
Sbjct: 329 ALPQGAF---QGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRN 385
Query: 609 QVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNI 668
SL+S+ L N + ++ VFG A LTE+ + N + C C + F+ W+ + H +
Sbjct: 386 LSSLESVQLDHNQLETLPGDVFG-ALPRLTEVLLGHNSWRCDC-GLGPFLGWLRQ-HLGL 442
Query: 669 PELSSHYLCNTPPHYHGFPV 688
C P + G P+
Sbjct: 443 VGGEEPPRCAGPGAHAGLPL 462
Score = 96.3 bits (238), Expect = 1e-19
Identities = 119/466 (25%), Positives = 193/466 (41%), Gaps = 71/466 (15%)
Query: 1 MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPD-DLPTNITV---- 55
+R TL C GLL KC V + A CS + ++ LPTN+T
Sbjct: 2 LRGTLLCAVL--GLLRAQPFPCPPACKC-VFRDAAQCSGGDVARISALGLPTNLTHILLF 58
Query: 56 --------------------LNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELC 95
L ++ + + + F+ +L +L + N I+ L L
Sbjct: 59 GMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALL 118
Query: 96 QKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLS 155
K+ +L+ L L HN L + F NL EL L N + + + F +NL LDLS
Sbjct: 119 DKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLS 178
Query: 156 HNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPG 215
N L+ G L+ LLL +N++ +L S L+ + +L +L+ N I+ +PG
Sbjct: 179 GNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLN--SLGALTELQFHRNHIRSIAPG 236
Query: 216 CFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTN 275
F + P+L+ +L+LS + L+ + FL N
Sbjct: 237 AFDRL--------------PNLS-------------SLTLSRNHLAFLPSALFLHSH--N 267
Query: 276 LTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTK 335
LT+L L N L + F + L+ +L ++ L + + L +RYL +
Sbjct: 268 LTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGV-----T 322
Query: 336 QSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRT 395
S L++LP+ +FQ L L+ L + N + + + GL L+ +SL + LR
Sbjct: 323 LSPRLSALPQ---GAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN--RLRA 377
Query: 396 LTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLN 441
L F +L S L + L N++ + D F L L + LG N
Sbjct: 378 LPRALFRNL--SSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 35.0 bits (79), Expect = 0.32
Identities = 25/82 (30%), Positives = 35/82 (42%)
Query: 53 ITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELS 112
+ VL L N L LP +L + + N + L L + L L+ + L HN+L
Sbjct: 341 LQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE 400
Query: 113 QLSDKTFAFCTNLTELHLMSNS 134
L F LTE+ L NS
Sbjct: 401 TLPGDVFGALPRLTEVLLGHNS 422
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,868,724
Number of Sequences: 37866
Number of extensions: 1371301
Number of successful extensions: 7709
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 186
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 3209
Number of HSP's gapped (non-prelim): 1799
length of query: 904
length of database: 18,247,518
effective HSP length: 111
effective length of query: 793
effective length of database: 14,044,392
effective search space: 11137202856
effective search space used: 11137202856
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.