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Search of human proteins with 4507263
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
(198 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 410 e-115
gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 159 2e-39
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 159 2e-39
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 97 1e-20
gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] 90 1e-18
gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] 88 4e-18
gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] 84 6e-17
gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] 76 2e-14
gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] 76 2e-14
gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] 72 2e-13
gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] 72 2e-13
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 59 2e-09
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 59 2e-09
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 58 5e-09
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 58 5e-09
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 58 5e-09
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 54 7e-08
gi|58219064 Src homology 2 domain containing E [Homo sapiens] 48 5e-06
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 43 2e-04
gi|169790811 SHC (Src homology 2 domain containing) transforming... 43 2e-04
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 42 3e-04
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 42 3e-04
gi|224586793 src homology 2 domain-containing transforming prote... 42 4e-04
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 42 4e-04
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 41 6e-04
gi|106879210 Src homology 2 domain containing adaptor protein B ... 41 8e-04
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 40 0.001
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 40 0.001
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 40 0.001
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 40 0.001
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 410 bits (1053), Expect = e-115
Identities = 198/198 (100%), Positives = 198/198 (100%)
Query: 1 MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKE 60
MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKE
Sbjct: 1 MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKE 60
Query: 61 KLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFD 120
KLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFD
Sbjct: 61 KLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFD 120
Query: 121 SVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWG 180
SVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWG
Sbjct: 121 SVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWG 180
Query: 181 LPLPTRLKDYLEEYKFQV 198
LPLPTRLKDYLEEYKFQV
Sbjct: 181 LPLPTRLKDYLEEYKFQV 198
>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
[Homo sapiens]
Length = 275
Score = 159 bits (401), Expect = 2e-39
Identities = 88/211 (41%), Positives = 118/211 (55%), Gaps = 26/211 (12%)
Query: 14 EGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIR 73
EGT +Q + +P +AK L ++GWYWGS+T +EA++ L++ PEGTFL+R
Sbjct: 65 EGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVR 124
Query: 74 DSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMC 133
DS+H YL T+SVKT+ GPTN+RIEY D FRLDS + ++ F VV L+ +YV C
Sbjct: 125 DSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASC 184
Query: 134 -KDKRTG-----------------------PEAPRNGTVHLYLTKPLY--TSAPSLQHLC 167
D R+ P P VHL L +P +SA SLQHLC
Sbjct: 185 TADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLC 244
Query: 168 RLTINKCTGAIWGLPLPTRLKDYLEEYKFQV 198
RL IN+ + LPLP R+ DYL +Y FQ+
Sbjct: 245 RLVINRLVADVDCLPLPRRMADYLRQYPFQL 275
>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
Length = 258
Score = 159 bits (401), Expect = 2e-39
Identities = 88/211 (41%), Positives = 118/211 (55%), Gaps = 26/211 (12%)
Query: 14 EGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIR 73
EGT +Q + +P +AK L ++GWYWGS+T +EA++ L++ PEGTFL+R
Sbjct: 48 EGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVR 107
Query: 74 DSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMC 133
DS+H YL T+SVKT+ GPTN+RIEY D FRLDS + ++ F VV L+ +YV C
Sbjct: 108 DSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASC 167
Query: 134 -KDKRTG-----------------------PEAPRNGTVHLYLTKPLY--TSAPSLQHLC 167
D R+ P P VHL L +P +SA SLQHLC
Sbjct: 168 TADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLC 227
Query: 168 RLTINKCTGAIWGLPLPTRLKDYLEEYKFQV 198
RL IN+ + LPLP R+ DYL +Y FQ+
Sbjct: 228 RLVINRLVADVDCLPLPRRMADYLRQYPFQL 258
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 96.7 bits (239), Expect = 1e-20
Identities = 59/168 (35%), Positives = 93/168 (55%), Gaps = 17/168 (10%)
Query: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95
L + L++L + GWYWG +T EA+ KL P+G+FL+RDSS YLL++S ++ +
Sbjct: 372 LTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHT 431
Query: 96 RIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTG------PEAPRNGTVH 149
RIE+ +G+F + ++ S+V LI++ + +D G P + T
Sbjct: 432 RIEHSNGRFSFYE----QPDVEGHTSIVDLIEHSI---RDSENGAFCYSRSRLPGSATYP 484
Query: 150 LYLTKPL--YTSAPSLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEE 193
+ LT P+ + SLQ+LCR I + T I LPLP ++KDYL+E
Sbjct: 485 VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQE 532
>gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens]
Length = 225
Score = 89.7 bits (221), Expect = 1e-18
Identities = 58/188 (30%), Positives = 94/188 (50%), Gaps = 29/188 (15%)
Query: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95
+ A+R+L ++G+YW ++T EA L P GTFLIRDSS + T+SVKT +G NL
Sbjct: 34 VVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNL 93
Query: 96 RIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY-------------------VQMCKDK 136
RI+ + G F L S + +FD V+ L+ +Y V
Sbjct: 94 RIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSA 153
Query: 137 RTGPEAPRNGTVHLY---------LTKPLYTSAPSLQHLCRLTINKCTGAIWGL-PLPTR 186
+ P +P ++Y L++PL ++ +LQHLCR T+N + + LP
Sbjct: 154 QPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGP 213
Query: 187 LKDYLEEY 194
++++L++Y
Sbjct: 214 IREFLDQY 221
>gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
Length = 211
Score = 88.2 bits (217), Expect = 4e-18
Identities = 57/167 (34%), Positives = 85/167 (50%), Gaps = 24/167 (14%)
Query: 35 RLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTN 94
R+ +A L G+YWG ++V+ A E+L+ P GTFL+RDS + +SVK ++GPT+
Sbjct: 66 RITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTS 125
Query: 95 LRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTK 154
+R+ +Q G+F LD + FD + L+++YV APR L
Sbjct: 126 IRVHFQAGRFHLD------GSRESFDCLFELLEHYV----------AAPRR-----MLGA 164
Query: 155 PL-YTSAPSLQHLCRLTINKCTGA--IWGLPLPTRLKDYLEEYKFQV 198
PL LQ LCR I G + +PL L+DYL + FQ+
Sbjct: 165 PLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI 211
>gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens]
Length = 581
Score = 84.3 bits (207), Expect = 6e-17
Identities = 57/175 (32%), Positives = 87/175 (49%), Gaps = 13/175 (7%)
Query: 31 PQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSA 90
P ++ A +LREL + GWYWG M +A+ KLK P+G+FL+RDSS Y+L++S ++
Sbjct: 383 PDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQG 442
Query: 91 GPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKD-------KRTGPEAP 143
+ R+E+ G F S+ C + SVV I + K+ + P P
Sbjct: 443 ITHHTRMEHYRGTF---SLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLP 499
Query: 144 RNGTVHLYLTKPLYTSAPSLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKF 196
V L +++ SLQHLCR I + I LPLP L Y+ ++ +
Sbjct: 500 PT-PVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYY 553
>gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 76.3 bits (186), Expect = 2e-14
Identities = 55/152 (36%), Positives = 80/152 (52%), Gaps = 16/152 (10%)
Query: 49 YWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDS 108
YWG M EA+ L+ PEGTFL+RDS+ DYL ++S + + RIE + F D+
Sbjct: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
Query: 109 -IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLC 167
CV +V L+++Y KD + T+ L T P SLQ++C
Sbjct: 442 HDPCVFHS----STVTGLLEHY----KDPSSCMFFEPLLTISLNRTFPF-----SLQYIC 488
Query: 168 RLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197
R I +CT I GLPLP+ L+D+L+EY ++
Sbjct: 489 RAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520
>gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 76.3 bits (186), Expect = 2e-14
Identities = 55/152 (36%), Positives = 80/152 (52%), Gaps = 16/152 (10%)
Query: 49 YWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDS 108
YWG M EA+ L+ PEGTFL+RDS+ DYL ++S + + RIE + F D+
Sbjct: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
Query: 109 -IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLC 167
CV +V L+++Y KD + T+ L T P SLQ++C
Sbjct: 442 HDPCVFHS----STVTGLLEHY----KDPSSCMFFEPLLTISLNRTFPF-----SLQYIC 488
Query: 168 RLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197
R I +CT I GLPLP+ L+D+L+EY ++
Sbjct: 489 RAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520
>gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 72.4 bits (176), Expect = 2e-13
Identities = 56/166 (33%), Positives = 82/166 (49%), Gaps = 18/166 (10%)
Query: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95
L L ++ YWG M A+ L+ PEGTFL+RDS+ DYL ++S + + +
Sbjct: 274 LVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHA 333
Query: 96 RIEYQDGKFRLDS-IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTK 154
RIE + F D+ CV + L+++Y KD P A L+
Sbjct: 334 RIEQWNHNFSFDAHDPCVFHS----PDITGLLEHY----KD----PSACM--FFEPLLST 379
Query: 155 PLYTSAP-SLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197
PL + P SLQH+CR I CT I LP+P+ +K YL+EY ++
Sbjct: 380 PLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYK 425
>gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 72.4 bits (176), Expect = 2e-13
Identities = 56/166 (33%), Positives = 82/166 (49%), Gaps = 18/166 (10%)
Query: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95
L L ++ YWG M A+ L+ PEGTFL+RDS+ DYL ++S + + +
Sbjct: 274 LVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHA 333
Query: 96 RIEYQDGKFRLDS-IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTK 154
RIE + F D+ CV + L+++Y KD P A L+
Sbjct: 334 RIEQWNHNFSFDAHDPCVFHS----PDITGLLEHY----KD----PSACM--FFEPLLST 379
Query: 155 PLYTSAP-SLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197
PL + P SLQH+CR I CT I LP+P+ +K YL+EY ++
Sbjct: 380 PLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYK 425
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 59.3 bits (142), Expect = 2e-09
Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 16/108 (14%)
Query: 29 PSPQAARLAKALRE----LGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYL 81
P P + + +++ L WYWG ++ E +KL++ P+GTFL+RD+S DY
Sbjct: 42 PKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYT 101
Query: 82 LTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129
LT+ + ++I ++DGK+ + F+SVV LI++Y
Sbjct: 102 LTL--RKGGNNKLIKIYHRDGKYGFSDPL-------TFNSVVELINHY 140
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 59.3 bits (142), Expect = 2e-09
Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 16/108 (14%)
Query: 29 PSPQAARLAKALRE----LGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYL 81
P P + + +++ L WYWG ++ E +KL++ P+GTFL+RD+S DY
Sbjct: 42 PKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYT 101
Query: 82 LTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129
LT+ + ++I ++DGK+ + F+SVV LI++Y
Sbjct: 102 LTL--RKGGNNKLIKIYHRDGKYGFSDPL-------TFNSVVELINHY 140
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 58.2 bits (139), Expect = 5e-09
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 12/85 (14%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTISVKTSAGPTNLRIEYQDGKF 104
WYWG ++ E EKL++ +GTFL+RD+S H DY LT+ + ++I ++DGK+
Sbjct: 63 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL--RKGGNNKLIKIFHRDGKY 120
Query: 105 RLDSIICVKSKLKQFDSVVHLIDYY 129
+ F SVV LI++Y
Sbjct: 121 GFSDPL-------TFSSVVELINHY 138
Score = 29.3 bits (64), Expect = 2.3
Identities = 13/29 (44%), Positives = 19/29 (65%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76
W GS N+A+ L+ +GTFL+R+SS
Sbjct: 354 WNVGSSNRNKAENLLRGKRDGTFLVRESS 382
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 58.2 bits (139), Expect = 5e-09
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 12/85 (14%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTISVKTSAGPTNLRIEYQDGKF 104
WYWG ++ E EKL++ +GTFL+RD+S H DY LT+ + ++I ++DGK+
Sbjct: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL--RKGGNNKLIKIFHRDGKY 90
Query: 105 RLDSIICVKSKLKQFDSVVHLIDYY 129
+ F SVV LI++Y
Sbjct: 91 GFSDPL-------TFSSVVELINHY 108
Score = 29.3 bits (64), Expect = 2.3
Identities = 13/29 (44%), Positives = 19/29 (65%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76
W GS N+A+ L+ +GTFL+R+SS
Sbjct: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESS 352
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 58.2 bits (139), Expect = 5e-09
Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 12/85 (14%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTISVKTSAGPTNLRIEYQDGKF 104
WYWG ++ E EKL++ +GTFL+RD+S H DY LT+ + ++I ++DGK+
Sbjct: 333 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL--RKGGNNKLIKIFHRDGKY 390
Query: 105 RLDSIICVKSKLKQFDSVVHLIDYY 129
+ F SVV LI++Y
Sbjct: 391 GFSDPL-------TFSSVVELINHY 408
Score = 29.3 bits (64), Expect = 2.3
Identities = 13/29 (44%), Positives = 19/29 (65%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76
W GS N+A+ L+ +GTFL+R+SS
Sbjct: 624 WNVGSSNRNKAENLLRGKRDGTFLVRESS 652
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 54.3 bits (129), Expect = 7e-08
Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 12/105 (11%)
Query: 28 EPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTI 84
+P+P + L WYWG ++ E EKL++ P+GTFL+RD+S +Y LT+
Sbjct: 310 KPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTL 369
Query: 85 SVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129
+ +++ ++DG + S+ F SVV LI++Y
Sbjct: 370 --RKGGNNKLIKVFHRDGHYGF-------SEPLTFCSVVDLINHY 405
Score = 32.0 bits (71), Expect = 0.35
Identities = 14/29 (48%), Positives = 19/29 (65%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76
WY G + +A+E L +GTFLIR+SS
Sbjct: 622 WYVGKINRTQAEEMLSGKRDGTFLIRESS 650
>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
Length = 495
Score = 48.1 bits (113), Expect = 5e-06
Identities = 29/112 (25%), Positives = 58/112 (51%), Gaps = 15/112 (13%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRI-EYQDGKFRL 106
WY G+++ EA+ +L+ E +L+R+S + +I++KTS G ++ + + +D K+ L
Sbjct: 395 WYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTL 454
Query: 107 DSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYT 158
+ V FDS+ ++ YY + + P G H+ L P+++
Sbjct: 455 NQTSAV------FDSIPEVVHYY--------SNEKLPFKGAEHMTLLYPVHS 492
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 42.7 bits (99), Expect = 2e-04
Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 29 PSPQAAR--LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISV 86
PSP R +A +L Q WY G M+ A+ L+ +G FL+RDS + ++
Sbjct: 359 PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRA--DGDFLVRDSVTNPGQYVLTG 416
Query: 87 KTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQ 131
+ P +L + +G R ++ F+S+ HLID+++Q
Sbjct: 417 MHAGQPKHLLLVDPEGVVRTKDVL--------FESISHLIDHHLQ 453
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 42.7 bits (99), Expect = 2e-04
Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 12/105 (11%)
Query: 29 PSPQAAR--LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISV 86
PSP R +A +L Q WY G M+ A+ L+ +G FL+RDS + ++
Sbjct: 466 PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRA--DGDFLVRDSVTNPGQYVLTG 523
Query: 87 KTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQ 131
+ P +L + +G R ++ F+S+ HLID+++Q
Sbjct: 524 MHAGQPKHLLLVDPEGVVRTKDVL--------FESISHLIDHHLQ 560
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 42.4 bits (98), Expect = 3e-04
Identities = 24/83 (28%), Positives = 48/83 (57%), Gaps = 9/83 (10%)
Query: 48 WYWGSMTVNEAKEKLKE-APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRL 106
WY+G++T ++A+ L E EG FLIRDS S ++S+K S + +++ +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQL------V 338
Query: 107 DSIICVKSKLKQFDSVVHLIDYY 129
D++ C+ ++F ++ L+++Y
Sbjct: 339 DNVYCIGQ--RRFHTMDELVEHY 359
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 42.4 bits (98), Expect = 3e-04
Identities = 24/83 (28%), Positives = 48/83 (57%), Gaps = 9/83 (10%)
Query: 48 WYWGSMTVNEAKEKLKE-APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRL 106
WY+G++T ++A+ L E EG FLIRDS S ++S+K S + +++ +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQL------V 338
Query: 107 DSIICVKSKLKQFDSVVHLIDYY 129
D++ C+ ++F ++ L+++Y
Sbjct: 339 DNVYCIGQ--RRFHTMDELVEHY 359
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 41.6 bits (96), Expect = 4e-04
Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 12/111 (10%)
Query: 23 AGSAEEPSPQAARL--AKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDY 80
A S E SP + R AK L EL WY G M+ EA+ L++ +G FL+R S+ +
Sbjct: 472 AASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEK--DGDFLVRKSTTNPG 529
Query: 81 LLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQ 131
++ + +L + +G +++K + FDS+ HLI+++++
Sbjct: 530 SFVLTGMHNGQAKHLLLVDPEG--------TIRTKDRVFDSISHLINHHLE 572
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 41.6 bits (96), Expect = 4e-04
Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 3/98 (3%)
Query: 25 SAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKL-KEAPEGTFLIRDSSHSDYLLT 83
S ++PS +R L GWY G++T + A+ L +G++L+RDS+ + L +
Sbjct: 12 STQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYS 71
Query: 84 ISVKTSAGPTNLRIEY--QDGKFRLDSIICVKSKLKQF 119
+SV+ + +EY KF + +K +K F
Sbjct: 72 LSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHF 109
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 41.2 bits (95), Expect = 6e-04
Identities = 29/108 (26%), Positives = 56/108 (51%), Gaps = 11/108 (10%)
Query: 25 SAEEPSP-QAARLAKALR-ELGQTGWYWGSMTVNEAKEKLKE-APEGTFLIRDSSHSDYL 81
S EPSP Q + +L + WY+G +T ++A+ L E EG FLIRDS S
Sbjct: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
Query: 82 LTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129
++S+K + +++ + +++ C+ ++F ++ L+++Y
Sbjct: 317 FSVSLKAQGKNKHFKVQLK------ETVYCIGQ--RKFSTMEELVEHY 356
>gi|106879210 Src homology 2 domain containing adaptor protein B
[Homo sapiens]
Length = 509
Score = 40.8 bits (94), Expect = 8e-04
Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 14/109 (12%)
Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLD 107
WY G+++ +A+ L+ E ++L+R+S S + ++S++++ G ++++ K+ L
Sbjct: 410 WYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLG 469
Query: 108 SIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPL 156
FDSV +I YY T + P G HL L P+
Sbjct: 470 ------QNSPPFDSVPEVIHYY--------TTRKLPIKGAEHLSLLYPV 504
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 40.4 bits (93), Expect = 0.001
Identities = 19/43 (44%), Positives = 28/43 (65%), Gaps = 2/43 (4%)
Query: 45 QTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHS--DYLLTIS 85
++ WYWG ++ EA L+ G FL+RDSS S DY+L++S
Sbjct: 10 RSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVS 52
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 40.4 bits (93), Expect = 0.001
Identities = 19/43 (44%), Positives = 28/43 (65%), Gaps = 2/43 (4%)
Query: 45 QTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHS--DYLLTIS 85
++ WYWG ++ EA L+ G FL+RDSS S DY+L++S
Sbjct: 10 RSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVS 52
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 40.4 bits (93), Expect = 0.001
Identities = 24/91 (26%), Positives = 45/91 (49%), Gaps = 9/91 (9%)
Query: 41 RELGQTG--WYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIE 98
RE+ T W+ G+M + LK GT+LIR+ IS+K + ++++
Sbjct: 664 REIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVV 723
Query: 99 YQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129
+D + ++ K+FDS++ L++YY
Sbjct: 724 EKDNWIHI-------TEAKKFDSLLELVEYY 747
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 40.4 bits (93), Expect = 0.001
Identities = 24/91 (26%), Positives = 45/91 (49%), Gaps = 9/91 (9%)
Query: 41 RELGQTG--WYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIE 98
RE+ T W+ G+M + LK GT+LIR+ IS+K + ++++
Sbjct: 654 REIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVV 713
Query: 99 YQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129
+D + ++ K+FDS++ L++YY
Sbjct: 714 EKDNWIHI-------TEAKKFDSLLELVEYY 737
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,430,283
Number of Sequences: 37866
Number of extensions: 377462
Number of successful extensions: 1354
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 1249
Number of HSP's gapped (non-prelim): 149
length of query: 198
length of database: 18,247,518
effective HSP length: 97
effective length of query: 101
effective length of database: 14,574,516
effective search space: 1472026116
effective search space used: 1472026116
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.