BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] (198 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 410 e-115 gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 159 2e-39 gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 159 2e-39 gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 97 1e-20 gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] 90 1e-18 gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] 88 4e-18 gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] 84 6e-17 gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] 76 2e-14 gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] 76 2e-14 gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] 72 2e-13 gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] 72 2e-13 gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 59 2e-09 gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 59 2e-09 gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 58 5e-09 gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 58 5e-09 gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 58 5e-09 gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 54 7e-08 gi|58219064 Src homology 2 domain containing E [Homo sapiens] 48 5e-06 gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 43 2e-04 gi|169790811 SHC (Src homology 2 domain containing) transforming... 43 2e-04 gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 42 3e-04 gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 42 3e-04 gi|224586793 src homology 2 domain-containing transforming prote... 42 4e-04 gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 42 4e-04 gi|5453754 NCK adaptor protein 1 [Homo sapiens] 41 6e-04 gi|106879210 Src homology 2 domain containing adaptor protein B ... 41 8e-04 gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 40 0.001 gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 40 0.001 gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 40 0.001 gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 40 0.001 >gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] Length = 198 Score = 410 bits (1053), Expect = e-115 Identities = 198/198 (100%), Positives = 198/198 (100%) Query: 1 MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKE 60 MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKE Sbjct: 1 MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKE 60 Query: 61 KLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFD 120 KLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFD Sbjct: 61 KLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFD 120 Query: 121 SVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWG 180 SVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWG Sbjct: 121 SVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWG 180 Query: 181 LPLPTRLKDYLEEYKFQV 198 LPLPTRLKDYLEEYKFQV Sbjct: 181 LPLPTRLKDYLEEYKFQV 198 >gi|195976771 cytokine-inducible SH2-containing protein isoform 1 [Homo sapiens] Length = 275 Score = 159 bits (401), Expect = 2e-39 Identities = 88/211 (41%), Positives = 118/211 (55%), Gaps = 26/211 (12%) Query: 14 EGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIR 73 EGT +Q + +P +AK L ++GWYWGS+T +EA++ L++ PEGTFL+R Sbjct: 65 EGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVR 124 Query: 74 DSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMC 133 DS+H YL T+SVKT+ GPTN+RIEY D FRLDS + ++ F VV L+ +YV C Sbjct: 125 DSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASC 184 Query: 134 -KDKRTG-----------------------PEAPRNGTVHLYLTKPLY--TSAPSLQHLC 167 D R+ P P VHL L +P +SA SLQHLC Sbjct: 185 TADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLC 244 Query: 168 RLTINKCTGAIWGLPLPTRLKDYLEEYKFQV 198 RL IN+ + LPLP R+ DYL +Y FQ+ Sbjct: 245 RLVINRLVADVDCLPLPRRMADYLRQYPFQL 275 >gi|21614507 cytokine-inducible SH2-containing protein isoform 2 [Homo sapiens] Length = 258 Score = 159 bits (401), Expect = 2e-39 Identities = 88/211 (41%), Positives = 118/211 (55%), Gaps = 26/211 (12%) Query: 14 EGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIR 73 EGT +Q + +P +AK L ++GWYWGS+T +EA++ L++ PEGTFL+R Sbjct: 48 EGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVR 107 Query: 74 DSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMC 133 DS+H YL T+SVKT+ GPTN+RIEY D FRLDS + ++ F VV L+ +YV C Sbjct: 108 DSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASC 167 Query: 134 -KDKRTG-----------------------PEAPRNGTVHLYLTKPLY--TSAPSLQHLC 167 D R+ P P VHL L +P +SA SLQHLC Sbjct: 168 TADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLC 227 Query: 168 RLTINKCTGAIWGLPLPTRLKDYLEEYKFQV 198 RL IN+ + LPLP R+ DYL +Y FQ+ Sbjct: 228 RLVINRLVADVDCLPLPRRMADYLRQYPFQL 258 >gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] Length = 535 Score = 96.7 bits (239), Expect = 1e-20 Identities = 59/168 (35%), Positives = 93/168 (55%), Gaps = 17/168 (10%) Query: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95 L + L++L + GWYWG +T EA+ KL P+G+FL+RDSS YLL++S ++ + Sbjct: 372 LTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHT 431 Query: 96 RIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTG------PEAPRNGTVH 149 RIE+ +G+F + ++ S+V LI++ + +D G P + T Sbjct: 432 RIEHSNGRFSFYE----QPDVEGHTSIVDLIEHSI---RDSENGAFCYSRSRLPGSATYP 484 Query: 150 LYLTKPL--YTSAPSLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEE 193 + LT P+ + SLQ+LCR I + T I LPLP ++KDYL+E Sbjct: 485 VRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQE 532 >gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] Length = 225 Score = 89.7 bits (221), Expect = 1e-18 Identities = 58/188 (30%), Positives = 94/188 (50%), Gaps = 29/188 (15%) Query: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95 + A+R+L ++G+YW ++T EA L P GTFLIRDSS + T+SVKT +G NL Sbjct: 34 VVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNL 93 Query: 96 RIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY-------------------VQMCKDK 136 RI+ + G F L S + +FD V+ L+ +Y V Sbjct: 94 RIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSA 153 Query: 137 RTGPEAPRNGTVHLY---------LTKPLYTSAPSLQHLCRLTINKCTGAIWGL-PLPTR 186 + P +P ++Y L++PL ++ +LQHLCR T+N + + LP Sbjct: 154 QPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGP 213 Query: 187 LKDYLEEY 194 ++++L++Y Sbjct: 214 IREFLDQY 221 >gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] Length = 211 Score = 88.2 bits (217), Expect = 4e-18 Identities = 57/167 (34%), Positives = 85/167 (50%), Gaps = 24/167 (14%) Query: 35 RLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTN 94 R+ +A L G+YWG ++V+ A E+L+ P GTFL+RDS + +SVK ++GPT+ Sbjct: 66 RITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTS 125 Query: 95 LRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTK 154 +R+ +Q G+F LD + FD + L+++YV APR L Sbjct: 126 IRVHFQAGRFHLD------GSRESFDCLFELLEHYV----------AAPRR-----MLGA 164 Query: 155 PL-YTSAPSLQHLCRLTINKCTGA--IWGLPLPTRLKDYLEEYKFQV 198 PL LQ LCR I G + +PL L+DYL + FQ+ Sbjct: 165 PLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI 211 >gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] Length = 581 Score = 84.3 bits (207), Expect = 6e-17 Identities = 57/175 (32%), Positives = 87/175 (49%), Gaps = 13/175 (7%) Query: 31 PQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSA 90 P ++ A +LREL + GWYWG M +A+ KLK P+G+FL+RDSS Y+L++S ++ Sbjct: 383 PDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQG 442 Query: 91 GPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKD-------KRTGPEAP 143 + R+E+ G F S+ C + SVV I + K+ + P P Sbjct: 443 ITHHTRMEHYRGTF---SLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLP 499 Query: 144 RNGTVHLYLTKPLYTSAPSLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKF 196 V L +++ SLQHLCR I + I LPLP L Y+ ++ + Sbjct: 500 PT-PVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYY 553 >gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] Length = 536 Score = 76.3 bits (186), Expect = 2e-14 Identities = 55/152 (36%), Positives = 80/152 (52%), Gaps = 16/152 (10%) Query: 49 YWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDS 108 YWG M EA+ L+ PEGTFL+RDS+ DYL ++S + + RIE + F D+ Sbjct: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441 Query: 109 -IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLC 167 CV +V L+++Y KD + T+ L T P SLQ++C Sbjct: 442 HDPCVFHS----STVTGLLEHY----KDPSSCMFFEPLLTISLNRTFPF-----SLQYIC 488 Query: 168 RLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197 R I +CT I GLPLP+ L+D+L+EY ++ Sbjct: 489 RAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520 >gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] Length = 536 Score = 76.3 bits (186), Expect = 2e-14 Identities = 55/152 (36%), Positives = 80/152 (52%), Gaps = 16/152 (10%) Query: 49 YWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDS 108 YWG M EA+ L+ PEGTFL+RDS+ DYL ++S + + RIE + F D+ Sbjct: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441 Query: 109 -IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLC 167 CV +V L+++Y KD + T+ L T P SLQ++C Sbjct: 442 HDPCVFHS----STVTGLLEHY----KDPSSCMFFEPLLTISLNRTFPF-----SLQYIC 488 Query: 168 RLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197 R I +CT I GLPLP+ L+D+L+EY ++ Sbjct: 489 RAVICRCTTYDGIDGLPLPSMLQDFLKEYHYK 520 >gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] Length = 440 Score = 72.4 bits (176), Expect = 2e-13 Identities = 56/166 (33%), Positives = 82/166 (49%), Gaps = 18/166 (10%) Query: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95 L L ++ YWG M A+ L+ PEGTFL+RDS+ DYL ++S + + + Sbjct: 274 LVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHA 333 Query: 96 RIEYQDGKFRLDS-IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTK 154 RIE + F D+ CV + L+++Y KD P A L+ Sbjct: 334 RIEQWNHNFSFDAHDPCVFHS----PDITGLLEHY----KD----PSACM--FFEPLLST 379 Query: 155 PLYTSAP-SLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197 PL + P SLQH+CR I CT I LP+P+ +K YL+EY ++ Sbjct: 380 PLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYK 425 >gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] Length = 440 Score = 72.4 bits (176), Expect = 2e-13 Identities = 56/166 (33%), Positives = 82/166 (49%), Gaps = 18/166 (10%) Query: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95 L L ++ YWG M A+ L+ PEGTFL+RDS+ DYL ++S + + + Sbjct: 274 LVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHA 333 Query: 96 RIEYQDGKFRLDS-IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTK 154 RIE + F D+ CV + L+++Y KD P A L+ Sbjct: 334 RIEQWNHNFSFDAHDPCVFHS----PDITGLLEHY----KD----PSACM--FFEPLLST 379 Query: 155 PLYTSAP-SLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197 PL + P SLQH+CR I CT I LP+P+ +K YL+EY ++ Sbjct: 380 PLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYK 425 >gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) [Homo sapiens] Length = 461 Score = 59.3 bits (142), Expect = 2e-09 Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 16/108 (14%) Query: 29 PSPQAARLAKALRE----LGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYL 81 P P + + +++ L WYWG ++ E +KL++ P+GTFL+RD+S DY Sbjct: 42 PKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYT 101 Query: 82 LTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129 LT+ + ++I ++DGK+ + F+SVV LI++Y Sbjct: 102 LTL--RKGGNNKLIKIYHRDGKYGFSDPL-------TFNSVVELINHY 140 >gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) [Homo sapiens] Length = 461 Score = 59.3 bits (142), Expect = 2e-09 Identities = 33/108 (30%), Positives = 57/108 (52%), Gaps = 16/108 (14%) Query: 29 PSPQAARLAKALRE----LGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYL 81 P P + + +++ L WYWG ++ E +KL++ P+GTFL+RD+S DY Sbjct: 42 PKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYT 101 Query: 82 LTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129 LT+ + ++I ++DGK+ + F+SVV LI++Y Sbjct: 102 LTL--RKGGNNKLIKIYHRDGKYGFSDPL-------TFNSVVELINHY 140 >gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) isoform 2 [Homo sapiens] Length = 454 Score = 58.2 bits (139), Expect = 5e-09 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 12/85 (14%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTISVKTSAGPTNLRIEYQDGKF 104 WYWG ++ E EKL++ +GTFL+RD+S H DY LT+ + ++I ++DGK+ Sbjct: 63 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL--RKGGNNKLIKIFHRDGKY 120 Query: 105 RLDSIICVKSKLKQFDSVVHLIDYY 129 + F SVV LI++Y Sbjct: 121 GFSDPL-------TFSSVVELINHY 138 Score = 29.3 bits (64), Expect = 2.3 Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76 W GS N+A+ L+ +GTFL+R+SS Sbjct: 354 WNVGSSNRNKAENLLRGKRDGTFLVRESS 382 >gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) isoform 3 [Homo sapiens] Length = 424 Score = 58.2 bits (139), Expect = 5e-09 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 12/85 (14%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTISVKTSAGPTNLRIEYQDGKF 104 WYWG ++ E EKL++ +GTFL+RD+S H DY LT+ + ++I ++DGK+ Sbjct: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL--RKGGNNKLIKIFHRDGKY 90 Query: 105 RLDSIICVKSKLKQFDSVVHLIDYY 129 + F SVV LI++Y Sbjct: 91 GFSDPL-------TFSSVVELINHY 108 Score = 29.3 bits (64), Expect = 2.3 Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76 W GS N+A+ L+ +GTFL+R+SS Sbjct: 324 WNVGSSNRNKAENLLRGKRDGTFLVRESS 352 >gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) isoform 1 [Homo sapiens] Length = 724 Score = 58.2 bits (139), Expect = 5e-09 Identities = 31/85 (36%), Positives = 48/85 (56%), Gaps = 12/85 (14%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTISVKTSAGPTNLRIEYQDGKF 104 WYWG ++ E EKL++ +GTFL+RD+S H DY LT+ + ++I ++DGK+ Sbjct: 333 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTL--RKGGNNKLIKIFHRDGKY 390 Query: 105 RLDSIICVKSKLKQFDSVVHLIDYY 129 + F SVV LI++Y Sbjct: 391 GFSDPL-------TFSSVVELINHY 408 Score = 29.3 bits (64), Expect = 2.3 Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76 W GS N+A+ L+ +GTFL+R+SS Sbjct: 624 WNVGSSNRNKAENLLRGKRDGTFLVRESS 652 >gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Homo sapiens] Length = 728 Score = 54.3 bits (129), Expect = 7e-08 Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 12/105 (11%) Query: 28 EPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTI 84 +P+P + L WYWG ++ E EKL++ P+GTFL+RD+S +Y LT+ Sbjct: 310 KPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTL 369 Query: 85 SVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129 + +++ ++DG + S+ F SVV LI++Y Sbjct: 370 --RKGGNNKLIKVFHRDGHYGF-------SEPLTFCSVVDLINHY 405 Score = 32.0 bits (71), Expect = 0.35 Identities = 14/29 (48%), Positives = 19/29 (65%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76 WY G + +A+E L +GTFLIR+SS Sbjct: 622 WYVGKINRTQAEEMLSGKRDGTFLIRESS 650 >gi|58219064 Src homology 2 domain containing E [Homo sapiens] Length = 495 Score = 48.1 bits (113), Expect = 5e-06 Identities = 29/112 (25%), Positives = 58/112 (51%), Gaps = 15/112 (13%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRI-EYQDGKFRL 106 WY G+++ EA+ +L+ E +L+R+S + +I++KTS G ++ + + +D K+ L Sbjct: 395 WYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTL 454 Query: 107 DSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYT 158 + V FDS+ ++ YY + + P G H+ L P+++ Sbjct: 455 NQTSAV------FDSIPEVVHYY--------SNEKLPFKGAEHMTLLYPVHS 492 >gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo sapiens] Length = 475 Score = 42.7 bits (99), Expect = 2e-04 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 12/105 (11%) Query: 29 PSPQAAR--LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISV 86 PSP R +A +L Q WY G M+ A+ L+ +G FL+RDS + ++ Sbjct: 359 PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRA--DGDFLVRDSVTNPGQYVLTG 416 Query: 87 KTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQ 131 + P +L + +G R ++ F+S+ HLID+++Q Sbjct: 417 MHAGQPKHLLLVDPEGVVRTKDVL--------FESISHLIDHHLQ 453 >gi|169790811 SHC (Src homology 2 domain containing) transforming protein 2 [Homo sapiens] Length = 582 Score = 42.7 bits (99), Expect = 2e-04 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 12/105 (11%) Query: 29 PSPQAAR--LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISV 86 PSP R +A +L Q WY G M+ A+ L+ +G FL+RDS + ++ Sbjct: 466 PSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRA--DGDFLVRDSVTNPGQYVLTG 523 Query: 87 KTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQ 131 + P +L + +G R ++ F+S+ HLID+++Q Sbjct: 524 MHAGQPKHLLLVDPEGVVRTKDVL--------FESISHLIDHHLQ 560 >gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] Length = 380 Score = 42.4 bits (98), Expect = 3e-04 Identities = 24/83 (28%), Positives = 48/83 (57%), Gaps = 9/83 (10%) Query: 48 WYWGSMTVNEAKEKLKE-APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRL 106 WY+G++T ++A+ L E EG FLIRDS S ++S+K S + +++ + Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQL------V 338 Query: 107 DSIICVKSKLKQFDSVVHLIDYY 129 D++ C+ ++F ++ L+++Y Sbjct: 339 DNVYCIGQ--RRFHTMDELVEHY 359 >gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] Length = 380 Score = 42.4 bits (98), Expect = 3e-04 Identities = 24/83 (28%), Positives = 48/83 (57%), Gaps = 9/83 (10%) Query: 48 WYWGSMTVNEAKEKLKE-APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRL 106 WY+G++T ++A+ L E EG FLIRDS S ++S+K S + +++ + Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQL------V 338 Query: 107 DSIICVKSKLKQFDSVVHLIDYY 129 D++ C+ ++F ++ L+++Y Sbjct: 339 DNVYCIGQ--RRFHTMDELVEHY 359 >gi|224586793 src homology 2 domain-containing transforming protein C3 [Homo sapiens] Length = 594 Score = 41.6 bits (96), Expect = 4e-04 Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 12/111 (10%) Query: 23 AGSAEEPSPQAARL--AKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDY 80 A S E SP + R AK L EL WY G M+ EA+ L++ +G FL+R S+ + Sbjct: 472 AASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEK--DGDFLVRKSTTNPG 529 Query: 81 LLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQ 131 ++ + +L + +G +++K + FDS+ HLI+++++ Sbjct: 530 SFVLTGMHNGQAKHLLLVDPEG--------TIRTKDRVFDSISHLINHHLE 572 >gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinositides [Homo sapiens] Length = 280 Score = 41.6 bits (96), Expect = 4e-04 Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 3/98 (3%) Query: 25 SAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKL-KEAPEGTFLIRDSSHSDYLLT 83 S ++PS +R L GWY G++T + A+ L +G++L+RDS+ + L + Sbjct: 12 STQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYS 71 Query: 84 ISVKTSAGPTNLRIEY--QDGKFRLDSIICVKSKLKQF 119 +SV+ + +EY KF + +K +K F Sbjct: 72 LSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHF 109 >gi|5453754 NCK adaptor protein 1 [Homo sapiens] Length = 377 Score = 41.2 bits (95), Expect = 6e-04 Identities = 29/108 (26%), Positives = 56/108 (51%), Gaps = 11/108 (10%) Query: 25 SAEEPSP-QAARLAKALR-ELGQTGWYWGSMTVNEAKEKLKE-APEGTFLIRDSSHSDYL 81 S EPSP Q + +L + WY+G +T ++A+ L E EG FLIRDS S Sbjct: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316 Query: 82 LTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129 ++S+K + +++ + +++ C+ ++F ++ L+++Y Sbjct: 317 FSVSLKAQGKNKHFKVQLK------ETVYCIGQ--RKFSTMEELVEHY 356 >gi|106879210 Src homology 2 domain containing adaptor protein B [Homo sapiens] Length = 509 Score = 40.8 bits (94), Expect = 8e-04 Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 14/109 (12%) Query: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLD 107 WY G+++ +A+ L+ E ++L+R+S S + ++S++++ G ++++ K+ L Sbjct: 410 WYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLG 469 Query: 108 SIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPL 156 FDSV +I YY T + P G HL L P+ Sbjct: 470 ------QNSPPFDSVPEVIHYY--------TTRKLPIKGAEHLSLLYPV 504 >gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a [Homo sapiens] Length = 304 Score = 40.4 bits (93), Expect = 0.001 Identities = 19/43 (44%), Positives = 28/43 (65%), Gaps = 2/43 (4%) Query: 45 QTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHS--DYLLTIS 85 ++ WYWG ++ EA L+ G FL+RDSS S DY+L++S Sbjct: 10 RSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVS 52 >gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b [Homo sapiens] Length = 204 Score = 40.4 bits (93), Expect = 0.001 Identities = 19/43 (44%), Positives = 28/43 (65%), Gaps = 2/43 (4%) Query: 45 QTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHS--DYLLTIS 85 ++ WYWG ++ EA L+ G FL+RDSS S DY+L++S Sbjct: 10 RSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVS 52 >gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 [Homo sapiens] Length = 878 Score = 40.4 bits (93), Expect = 0.001 Identities = 24/91 (26%), Positives = 45/91 (49%), Gaps = 9/91 (9%) Query: 41 RELGQTG--WYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIE 98 RE+ T W+ G+M + LK GT+LIR+ IS+K + ++++ Sbjct: 664 REIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVV 723 Query: 99 YQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129 +D + ++ K+FDS++ L++YY Sbjct: 724 EKDNWIHI-------TEAKKFDSLLELVEYY 747 >gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [Homo sapiens] Length = 839 Score = 40.4 bits (93), Expect = 0.001 Identities = 24/91 (26%), Positives = 45/91 (49%), Gaps = 9/91 (9%) Query: 41 RELGQTG--WYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIE 98 RE+ T W+ G+M + LK GT+LIR+ IS+K + ++++ Sbjct: 654 REIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVV 713 Query: 99 YQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129 +D + ++ K+FDS++ L++YY Sbjct: 714 EKDNWIHI-------TEAKKFDSLLELVEYY 737 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.133 0.408 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 8,430,283 Number of Sequences: 37866 Number of extensions: 377462 Number of successful extensions: 1354 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 67 Number of HSP's successfully gapped in prelim test: 67 Number of HSP's that attempted gapping in prelim test: 1249 Number of HSP's gapped (non-prelim): 149 length of query: 198 length of database: 18,247,518 effective HSP length: 97 effective length of query: 101 effective length of database: 14,574,516 effective search space: 1472026116 effective search space used: 1472026116 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.