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Search of human proteins with 4506787
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506787 IQ motif containing GTPase activating protein 1
[Homo sapiens]
(1657 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506787 IQ motif containing GTPase activating protein 1 [Homo... 3256 0.0
gi|39753961 IQ motif containing GTPase activating protein 3 [Hom... 1916 0.0
gi|116089337 IQ motif containing GTPase activating protein 2 [Ho... 1492 0.0
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 75 4e-13
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 66 3e-10
gi|4759026 RAS protein activator like 1 [Homo sapiens] 60 2e-08
gi|42794779 myosin 18A isoform b [Homo sapiens] 52 5e-06
gi|28416946 myosin 18A isoform a [Homo sapiens] 52 5e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 52 6e-06
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 50 2e-05
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 50 2e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 49 3e-05
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 49 3e-05
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 49 3e-05
gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo s... 47 1e-04
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 47 1e-04
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 47 2e-04
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 47 2e-04
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 47 2e-04
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 47 2e-04
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 45 4e-04
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 45 4e-04
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 45 4e-04
gi|126116596 asp (abnormal spindle)-like, microcephaly associate... 45 6e-04
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 45 8e-04
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 45 8e-04
gi|156104908 myosin heavy chain 6 [Homo sapiens] 44 0.001
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 44 0.001
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 44 0.002
gi|156119615 myosin IXA [Homo sapiens] 44 0.002
>gi|4506787 IQ motif containing GTPase activating protein 1 [Homo
sapiens]
Length = 1657
Score = 3256 bits (8441), Expect = 0.0
Identities = 1657/1657 (100%), Positives = 1657/1657 (100%)
Query: 1 MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGE 60
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGE
Sbjct: 1 MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGE 60
Query: 61 DLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWL 120
DLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWL
Sbjct: 61 DLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWL 120
Query: 121 NAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE 180
NAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
Sbjct: 121 NAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE 180
Query: 181 EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAAL 240
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAAL
Sbjct: 181 EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAAL 240
Query: 241 KNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNI 300
KNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNI
Sbjct: 241 KNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNI 300
Query: 301 NKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS 360
NKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
Sbjct: 301 NKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS 360
Query: 361 GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQ 420
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQ
Sbjct: 361 GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQ 420
Query: 421 VYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLS 480
VYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLS
Sbjct: 421 VYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLS 480
Query: 481 SSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL 540
SSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
Sbjct: 481 SSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL 540
Query: 541 AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAV 600
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAV
Sbjct: 541 AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAV 600
Query: 601 LWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPEC 660
LWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPEC
Sbjct: 601 LWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPEC 660
Query: 661 GETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL 720
GETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
Sbjct: 661 GETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL 720
Query: 721 SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAIT 780
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAIT
Sbjct: 721 SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAIT 780
Query: 781 CIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDII 840
CIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDII
Sbjct: 781 CIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDII 840
Query: 841 KIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLI 900
KIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLI
Sbjct: 841 KIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLI 900
Query: 901 RSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKA 960
RSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKA
Sbjct: 901 RSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKA 960
Query: 961 LSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEY 1020
LSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEY
Sbjct: 961 LSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEY 1020
Query: 1021 LLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIM 1080
LLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIM
Sbjct: 1021 LLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIM 1080
Query: 1081 DDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRA 1140
DDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRA
Sbjct: 1081 DDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRA 1140
Query: 1141 VTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAI 1200
VTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAI
Sbjct: 1141 VTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAI 1200
Query: 1201 VAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQ 1260
VAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQ
Sbjct: 1201 VAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQ 1260
Query: 1261 KFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH 1320
KFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH
Sbjct: 1261 KFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH 1320
Query: 1321 NDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMD 1380
NDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMD
Sbjct: 1321 NDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMD 1380
Query: 1381 ARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKK 1440
ARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKK
Sbjct: 1381 ARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKK 1440
Query: 1441 SKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRK 1500
SKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRK
Sbjct: 1441 SKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRK 1500
Query: 1501 AELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKIS 1560
AELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKIS
Sbjct: 1501 AELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKIS 1560
Query: 1561 LKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQ 1620
LKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQ
Sbjct: 1561 LKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQ 1620
Query: 1621 DLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK 1657
DLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
Sbjct: 1621 DLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK 1657
>gi|39753961 IQ motif containing GTPase activating protein 3 [Homo
sapiens]
Length = 1631
Score = 1916 bits (4964), Expect = 0.0
Identities = 970/1635 (59%), Positives = 1250/1635 (76%), Gaps = 18/1635 (1%)
Query: 24 ERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGN 83
ERLTAEEMDE+RRQNVAY+YLC LEEAKRWMEACL E+LP ELEE LRNGV LAKLG+
Sbjct: 14 ERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGH 73
Query: 84 FFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRK 143
F+P VV LKKIYD EQ RY+ATGLHFRHTDN+ WL+A+ IGLP F+PETTDIYD+K
Sbjct: 74 CFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKK 133
Query: 144 NMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIG 203
NMPR +YCIHALSL+LF+LGLAPQI DLYGKV FT EE++NM +EL KYG+Q+PAFSKIG
Sbjct: 134 NMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIG 193
Query: 204 GILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILY 263
GILANELSVDEAA+HAAV+AINEA++R + DT AAL+NP+A+L NL EPLA+ YQ++L
Sbjct: 194 GILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLA 253
Query: 264 QAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALA 323
QAK +K NA+N + + D+Y+ LTQAEIQGNIN VN AL +D ALE+ A
Sbjct: 254 QAKMEKAANARNHDDRESQ--DIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPEA 311
Query: 324 LFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS-GQTDPLQKEELQSGVDAANSAA 382
L +ALQ PAL LRG+++ +DWYL+QL SD++QK Q G + L+KEE+Q+GV AAN+
Sbjct: 312 LLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTKG 371
Query: 383 QQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPE 442
Q Q L AV IN AI++GVA TV ELM PEAQLP VYP A+ +YQ ELA LQ+Q E
Sbjct: 372 DQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQGE 431
Query: 443 HNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELM 502
L EL VAVEMLS+V LINRALE+ D + W L + TGL +E EN QRY D L+
Sbjct: 432 --LGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALL 489
Query: 503 KLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQ 562
KL+ Q +F++WND+QA V VN QEE +R+LA+ LINEALD+G +KTL AL
Sbjct: 490 KLR-QERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALL 548
Query: 563 IPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQK 622
+PAA L+ V VA Y L+ AKR+KAQ D AVLWL+EI+ G+ ++N+DT AQ+
Sbjct: 549 LPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQR 608
Query: 623 FALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNN 682
ALG+ AIN+A++ G +T LR+P V L GV+P+C Y L A KK D
Sbjct: 609 MALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAKKQRPADT- 667
Query: 683 SKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLW 742
+ WV+H +K G YY +L+T +G W++PP N+ L+REEIQS+++ VTAAY+R+QLW
Sbjct: 668 AFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLW 727
Query: 743 LANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYL 802
AN G + +LQAR RG+LVRQ+F +FL+ +PA+ IQ+ WRGY+Q+K Y + L Y
Sbjct: 728 KANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYF 787
Query: 803 RSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAE 862
+++ D ++KIQ+ ARM AR++Y RL YF+ ++N I+KIQAF RA KA+DDY+ L++A
Sbjct: 788 KANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAP 847
Query: 863 DPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVK 922
PP+ VVR+F HLL+QS QDF E +L+K++EEV+ IRSNQQLE DLN+MDIKIGLLVK
Sbjct: 848 HPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVK 907
Query: 923 NKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTN 982
N+ITLQ+VVSH KKLTK+NKEQLSDMM+++KQKG LK+LSKEKR+KLEAYQHLFYLLQT
Sbjct: 908 NRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKG-LKSLSKEKRQKLEAYQHLFYLLQTQ 966
Query: 983 PTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQ 1042
P YLAKLIFQMPQNK+TKFM++VIF+LYNYAS++RE YLLL+LFKTALQEEIKSKV+Q Q
Sbjct: 967 PIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQ 1026
Query: 1043 EIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQM 1102
++VTGNPTV+++VV F R RGQ+AL++IL V++++++DK L++ TDPV +YK+W+NQ
Sbjct: 1027 DVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQT 1086
Query: 1103 ESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRF 1162
E+QTG+ S LPYDVTPEQAL+H EV+ RLD ++RN+ A+TDKFL AI SSVD+IPYGMR+
Sbjct: 1087 EAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRY 1146
Query: 1163 IAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQR 1222
+AKVLK +L EKFPDA + E+ K++GNLLYYR++NPA+VAPDAFDI+ ++AGG L QR
Sbjct: 1147 VAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQR 1206
Query: 1223 RNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVD 1282
LG++A++LQHAA+ K F G + HL ++N+YL +++ KFR+F AC VPE +++F VD
Sbjct: 1207 HALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVD 1266
Query: 1283 EYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIG 1342
EYSD+V + KP++YI++GE++NTH LLL+HQD IAP+H DP+HELL+DLGE+PTI LIG
Sbjct: 1267 EYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIG 1326
Query: 1343 ESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGE 1402
ES + L+K EVSLTLTNKF+ + + + R++LL+TK+L+ D+I+F PG+
Sbjct: 1327 ES---IAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGD 1383
Query: 1403 TLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTG 1462
TL EIL A+ EQEA H++ M RR A+TP+ +++ +S+ S L L EK+ ++
Sbjct: 1384 TLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRN 1443
Query: 1463 LKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGE 1522
L++L LG V +N YQ L++++A+DIRNQ R+R RRKAELVKLQ T L++K TFY E
Sbjct: 1444 LRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEE 1503
Query: 1523 QVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQV 1582
Q DYY YI+ CLD+LA K S GK K+ SL YTAA+L EKGVL+EIEDL
Sbjct: 1504 QGDYYSQYIRACLDHLAPDSKSS-------GKGKKQPSLHYTAAQLLEKGVLVEIEDLPA 1556
Query: 1583 NQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVN 1642
+ F+NVIF+I+P +E G FEV AKF+GV ME F LHYQDLLQLQYEGVAVMKLF++AKVN
Sbjct: 1557 SHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVN 1616
Query: 1643 VNLLIFLLNKKFYGK 1657
VNLLIFLLNKKF K
Sbjct: 1617 VNLLIFLLNKKFLRK 1631
>gi|116089337 IQ motif containing GTPase activating protein 2 [Homo
sapiens]
Length = 1575
Score = 1492 bits (3862), Expect = 0.0
Identities = 772/1429 (54%), Positives = 1040/1429 (72%), Gaps = 39/1429 (2%)
Query: 254 LASTYQDILYQAK--QDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALAN 311
+A QD+L + +++++N + E + + ++ + ++++ +A+
Sbjct: 161 IAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIA 220
Query: 312 IDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQT-------- 363
I+ A+E+G A L++P L + + Y K+L K++K ++ +
Sbjct: 221 INEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEE 280
Query: 364 ------DPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQ 417
+ L + E+Q ++ N R AAV INA I +G E T+L L PEAQ
Sbjct: 281 ERDAYEELLTQAEIQGNINKVN--------RQAAVDHINAVIPEGDPENTLLALKKPEAQ 332
Query: 418 LPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWK 477
LP VYPFAA +YQ EL LQ+Q+ + L H EL +AVEMLS+VAL+N+ALES D+ +V
Sbjct: 333 LPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVSVQN 392
Query: 478 QLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHE 537
QL S GL N+++ +RY + L+ +K + ++ + ++WN+IQ C+D VN +QEE++
Sbjct: 393 QLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEEND 452
Query: 538 RILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDE 597
R++A+G INEA+DEG+ +TL+ L +P A + V AQHYQD L AK +K + +
Sbjct: 453 RVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLGDSESV 512
Query: 598 SAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVI 657
S VLWLDEIQ + +N D A+++ + +N+ +E LS L+S +I
Sbjct: 513 SKVLWLDEIQQAVDDANVDEDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSNANDII 572
Query: 658 PECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNS 717
PEC + Y+ L +AK+ K ++ W+K + Y YY+N +++E W P + +
Sbjct: 573 PECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKESSWVTPESCLYKE 632
Query: 718 MQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIP 777
L+ +EI+ I VT Y RE +W A+E L+ R QA G ++R+EF +R +FL +Q
Sbjct: 633 SWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREEFEARKSFLHEQEE 692
Query: 778 AITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHIN 837
+ IQ+ W+GYKQ+K Y R + D +VKIQS RM ARK Y RLQYFRDH N
Sbjct: 693 NVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNN 752
Query: 838 DIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVI 897
+I+KIQ+ +RANKARDDYKTL+ +E+PP+ V+RKFV+LLDQSD DFQEEL++ ++REEV+
Sbjct: 753 EIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVV 812
Query: 898 TLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGG 957
T IR+NQQLE DLNLMDIKIGLLVKN+ITL+DV+SHSKKL KK ++ ++ N G
Sbjct: 813 TKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEME--ILNNTDNQG 870
Query: 958 LKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQR 1017
+K+LSKE+R+ LE YQ LFYLLQTNP YLAKLIFQMPQNKSTKFMD+VIFTLYNYASNQR
Sbjct: 871 IKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQR 930
Query: 1018 EEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVK 1077
EEYLLL+LFKTAL+EEIKSKVDQ+Q+IVTGNPTVIKMVVSFNRGARGQN LRQ+LAPVVK
Sbjct: 931 EEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVK 990
Query: 1078 EIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRN 1137
EI+DDKSL I T+PV++YK+WVNQ+E+QTGEASKLPYDVT EQAL + EVK +L++SI N
Sbjct: 991 EIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIEN 1050
Query: 1138 MRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMN 1197
+R VTDK L++I+SS+D +PYG+R+IAKVLK+S+HEKFPDA EDELLKI+GNLLYYRYMN
Sbjct: 1051 LRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMN 1110
Query: 1198 PAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQ 1257
PAIVAPD FDIID++AGGQ+ +DQRRNLGS+AK+LQHAASNK+F G+N HLS +N YLS+
Sbjct: 1111 PAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSE 1170
Query: 1258 SYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIA 1317
+YQ+FR++F+ AC+VPE ++KFN+D+Y+DLVT++KPVIYISI EII+TH+LLL+HQDAIA
Sbjct: 1171 TYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIA 1230
Query: 1318 PEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNK----EALAKTEVSLTLTNKFDVPG 1373
PE ND + ELL LGEVPT+ES +GE + + NDPNK L+KTE+SL LT+K+D+
Sbjct: 1231 PEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISLVLTSKYDI-- 1288
Query: 1374 DENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAK 1433
++ +D+R++++ TK+LI+DVIR QPG TLTEILETPAT++QE +H M RA+ D++
Sbjct: 1289 EDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSR 1348
Query: 1434 TPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQR 1493
TP++MK S+S+ ED+ L L++KK KIQ L+ L + G V +NKYQ+++N+IA+DIRNQR
Sbjct: 1349 TPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQR 1408
Query: 1494 RYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKG-----KVSKKP 1548
YR+ RKAEL KLQQT ALN KA FY EQ++YY +YIKTCLDNL K K+ K
Sbjct: 1409 IYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKG 1468
Query: 1549 REMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFM 1608
K++K + KYTAA+LHEKGVLL+I+DLQ NQFKNV F+I TE+VG F+V++KF+
Sbjct: 1469 EPKGAKRAKPV--KYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDVGIFDVRSKFL 1526
Query: 1609 GVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK 1657
GV+ME L+ QDLLQ+QYEGVAVMK+FD+ KVNVNLLI+LLNKKFYGK
Sbjct: 1527 GVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK 1575
Score = 521 bits (1342), Expect = e-147
Identities = 292/625 (46%), Positives = 397/625 (63%), Gaps = 33/625 (5%)
Query: 14 RPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLR 73
RP YGS++D+ERL+AEEMDERRRQN+AYEYLCHLEEAKRWME CL E+LPPTTELEEGLR
Sbjct: 11 RPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLR 70
Query: 74 NGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFY 133
NGVYLAKL FF+PK+VS KKIYD EQTRYK +GLHFRHTDN +QWL AM+ IGLPKIFY
Sbjct: 71 NGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFY 130
Query: 134 PETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYG 193
PETTD+YDRKN+PR IYCIHALSLYLFKLG+APQIQDL GKVDFTEEEI+NM+ ELEKYG
Sbjct: 131 PETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYG 190
Query: 194 IQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEP 253
IQMP+FSKIGGILANELSVDEAALHAAVIAINEA+++ I T L+NPNA+L +++
Sbjct: 191 IQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDN 250
Query: 254 LASTYQDILYQAKQDKMTNAKNRTE-NSERERDVYEELLTQAEIQGNINKVNTFSALANI 312
LA YQ L+ AK+ K NA+ + SE ERD YEELLTQAEIQGNINKVN +A+ +I
Sbjct: 251 LAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHI 310
Query: 313 DLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQ 372
+ + +GD AL+ P L + + Y +L + ++Q + L EEL
Sbjct: 311 NAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTM----NYLAHEELL 366
Query: 373 SGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKE 432
V+ L+AVAL+N A++ +L +P L + + Y
Sbjct: 367 IAVE-----------MLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANT 415
Query: 433 LATLQRQ---SPEHNLTHPELSVAVEMLS-----------SVALINRALESGDVNTVWKQ 478
L +++ + + NL+ E+ ++M++ +V IN A++ G+ +
Sbjct: 416 LLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLET 475
Query: 479 LSSSVTGLTNIEEENCQRYLDELMKLKAQ--AHAENNEFITW-NDIQACVDHVNLVVQEE 535
L +++++ + Q Y D L K+Q +E+ + W ++IQ VD N+
Sbjct: 476 LLLPTANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRA 535
Query: 536 HERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQ 595
+ + + +N+ L+ + L L+ + ++ E A Y D L++AK K++ +
Sbjct: 536 KQWVTLVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVS 595
Query: 596 DESAVLWLDEIQGGIWQSNKDTQEA 620
+ + L L+ + + N D++E+
Sbjct: 596 SDGSWLKLNLHKKYDYYYNTDSKES 620
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 75.5 bits (184), Expect = 4e-13
Identities = 73/313 (23%), Positives = 140/313 (44%), Gaps = 58/313 (18%)
Query: 1005 VIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARG 1064
V+ TL++ +LL +L +E++ D +Q + GN K +++F G
Sbjct: 1242 VLVTLFD------SRHLLYQLLWNMFSKEVEL-ADSMQTLFRGNSLASK-IMTFCFKVYG 1293
Query: 1065 QNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAH 1124
L+++L P+++ ++ + VD P + P ++L
Sbjct: 1294 ATYLQKLLDPLLRIVITSSDWQHVSFEVD-------------------PTRLEPSESLEE 1334
Query: 1125 EEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELL 1184
+ RN+ +T+KF AI+SS + P +R + L + ++FP +
Sbjct: 1335 NQ---------RNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFP----QNSI 1381
Query: 1185 KIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGD 1244
+G+ ++ R++NPAIV+P I+D ++ R L ++K+LQ A++ +F +
Sbjct: 1382 GAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFTKE 1437
Query: 1245 NAHLSIINEYLSQSYQKFRRFF-QTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEII 1303
H+ N+++ ++ RRFF A D P SD V + +IS G ++
Sbjct: 1438 E-HMRPFNDFVKSNFDAARRFFLDIASDCPT----------SDAV--NHSLSFISDGNVL 1484
Query: 1304 NTHTLLLDHQDAI 1316
H LL ++Q+ I
Sbjct: 1485 ALHRLLWNNQEKI 1497
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 65.9 bits (159), Expect = 3e-10
Identities = 74/334 (22%), Positives = 141/334 (42%), Gaps = 79/334 (23%)
Query: 1005 VIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARG 1064
V+ TL++ +LL +L +E++ D +Q + GN K +++F G
Sbjct: 1242 VLVTLFD------SRHLLYQLLWNMFSKEVEL-ADSMQTLFRGNSLASK-IMTFCFKVYG 1293
Query: 1065 QNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAH 1124
L+++L P+++ ++ + VD P + P ++L
Sbjct: 1294 ATYLQKLLDPLLRIVITSSDWQHVSFEVD-------------------PTRLEPSESLEE 1334
Query: 1125 EEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVL----------------- 1167
+ RN+ +T+KF AI+SS + P +R + L
Sbjct: 1335 NQ---------RNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEK 1385
Query: 1168 ----KDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRR 1223
K + ++FP + +G+ ++ R++NPAIV+P I+D ++ R
Sbjct: 1386 KENKKSVVSQRFP----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI----ER 1437
Query: 1224 NLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFF-QTACDVPELQDKFNVD 1282
L ++K+LQ A++ +F + H+ N+++ ++ RRFF A D P
Sbjct: 1438 GLKLMSKILQSIANHVLFTKEE-HMRPFNDFVKSNFDAARRFFLDIASDCPT-------- 1488
Query: 1283 EYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAI 1316
SD V + +IS G ++ H LL ++Q+ I
Sbjct: 1489 --SDAV--NHSLSFISDGNVLALHRLLWNNQEKI 1518
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 60.1 bits (144), Expect = 2e-08
Identities = 53/212 (25%), Positives = 95/212 (44%), Gaps = 25/212 (11%)
Query: 1064 GQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALA 1123
G L ++L PV+ + ++K ++ DP + G ++ + + AL+
Sbjct: 359 GMPYLHEVLKPVISRVFEEKKY-MELDPCKM----------DLGRTRRISF----KGALS 403
Query: 1124 HEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDEL 1183
E+++ ++S+ + + AIV SV + P MR K L + E+FP A ++
Sbjct: 404 EEQMR---ETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDV 460
Query: 1184 LKI-IGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFL 1242
+ I L+ R+ PAI+ P FD+ D A Q + R+L +AK +Q + L
Sbjct: 461 KYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTS----RSLLLLAKAVQSIGNLGQQL 516
Query: 1243 GDNAHL--SIINEYLSQSYQKFRRFFQTACDV 1272
G L + ++ +L Q + R F DV
Sbjct: 517 GQGKELWMAPLHPFLLQCVSRVRDFLDRLVDV 548
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 52.0 bits (123), Expect = 5e-06
Identities = 94/458 (20%), Positives = 179/458 (39%), Gaps = 57/458 (12%)
Query: 749 ITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQ---------SQWRGYKQKKAYQDRL 799
+T QA CRGYL RQ F+ R K Q AI C+Q W +K + +
Sbjct: 1192 LTLFQAACRGYLARQHFKKR----KIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLI 1247
Query: 800 AYLRS-----HKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIK--IQAFIRANKAR 852
S +KDE +IQ L + ++ R+ L+ D + I
Sbjct: 1248 EVQLSEEQIRNKDE--EIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTG 1305
Query: 853 DDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNL 912
+ L++AE + K + L ++++++M+M LIR+ ++ +++
Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRA-AEINGEVDD 1364
Query: 913 MDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQL----SDMMMINKQKGGLKALSKEKREK 968
D +K + +++V K+L ++ +++L + + ++ G L+A S+E +
Sbjct: 1365 DDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRA 1424
Query: 969 LEAY----QHLFYLLQTNPTYL-AKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLL 1023
L+ Q L LQ +L + + K + DS + + A ++ + L
Sbjct: 1425 LQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKL 1484
Query: 1024 RLFKTALQEEIKSKVDQIQE----IVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEI 1079
+ K L E S Q++E I V+ + + ++ LA V K++
Sbjct: 1485 QREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQL 1544
Query: 1080 MDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMR 1139
D L K K +++ Q G L E+ K RL+ + MR
Sbjct: 1545 RD---LEAKV------KDQEEELDEQAGTIQML------------EQAKLRLEMEMERMR 1583
Query: 1140 AVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPD 1177
K + + V++ + K ++ L E++ D
Sbjct: 1584 QTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1621
Score = 35.8 bits (81), Expect = 0.35
Identities = 82/387 (21%), Positives = 155/387 (40%), Gaps = 48/387 (12%)
Query: 254 LASTYQDILYQAKQDKMTNAKNRTENSERE---RDVYEELLTQAEIQGNINKVNTFSALA 310
L + QDI Q +D+ + AK + + + E +D EEL QA T L
Sbjct: 1519 LEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA---------GTIQMLE 1569
Query: 311 NIDLALEQGDALALFRALQSPALGLRGLQ----QQNSDWYLKQLLSDKQQKRQSGQTDPL 366
L LE + R S + R + +Q+ LKQ+ +++ + Q
Sbjct: 1570 QAKLRLEM--EMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR 1627
Query: 367 QKEELQSGV----DAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVY 422
+K EL+ + D N + ++RL + ++T L + + L +
Sbjct: 1628 EKRELEGKLATLSDQVNRRDFESEKRL-----------RKDLKRTKALLADAQLMLDHLK 1676
Query: 423 PFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSS 482
A ++E+A L+ Q E T +V V + + L+ D+ L
Sbjct: 1677 NSAPS--KREIAQLKNQLEESEFTCAA-AVKARKAMEVEIEDLHLQIDDIAKAKTALEEQ 1733
Query: 483 VTGLTNIEEE------NCQRYLDELMKLKAQAHAE-NNEFITWNDIQACVDHVNLVVQEE 535
++ L + E Q ++ELMK A A+ + + ND+QA ++ N QE
Sbjct: 1734 LSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQEL 1793
Query: 536 HERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQ 595
E++ A+ E L++ K+L + Q AK+ + E ++ T ++ A ++
Sbjct: 1794 QEKLQALQSQVEFLEQSMVDKSLVSRQ--EAKIREL--ETRLEFERTQVKRLESLASRLK 1849
Query: 596 DESAVLWLDEIQGGIWQSNKDTQEAQK 622
+ L +E I N++ ++ ++
Sbjct: 1850 ENMEKL-TEERDQRIAAENREKEQNKR 1875
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 52.0 bits (123), Expect = 5e-06
Identities = 94/458 (20%), Positives = 179/458 (39%), Gaps = 57/458 (12%)
Query: 749 ITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQ---------SQWRGYKQKKAYQDRL 799
+T QA CRGYL RQ F+ R K Q AI C+Q W +K + +
Sbjct: 1192 LTLFQAACRGYLARQHFKKR----KIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLI 1247
Query: 800 AYLRS-----HKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIK--IQAFIRANKAR 852
S +KDE +IQ L + ++ R+ L+ D + I
Sbjct: 1248 EVQLSEEQIRNKDE--EIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTG 1305
Query: 853 DDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNL 912
+ L++AE + K + L ++++++M+M LIR+ ++ +++
Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRA-AEINGEVDD 1364
Query: 913 MDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQL----SDMMMINKQKGGLKALSKEKREK 968
D +K + +++V K+L ++ +++L + + ++ G L+A S+E +
Sbjct: 1365 DDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRA 1424
Query: 969 LEAY----QHLFYLLQTNPTYL-AKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLL 1023
L+ Q L LQ +L + + K + DS + + A ++ + L
Sbjct: 1425 LQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKL 1484
Query: 1024 RLFKTALQEEIKSKVDQIQE----IVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEI 1079
+ K L E S Q++E I V+ + + ++ LA V K++
Sbjct: 1485 QREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQL 1544
Query: 1080 MDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMR 1139
D L K K +++ Q G L E+ K RL+ + MR
Sbjct: 1545 RD---LEAKV------KDQEEELDEQAGTIQML------------EQAKLRLEMEMERMR 1583
Query: 1140 AVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPD 1177
K + + V++ + K ++ L E++ D
Sbjct: 1584 QTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1621
Score = 35.8 bits (81), Expect = 0.35
Identities = 82/387 (21%), Positives = 155/387 (40%), Gaps = 48/387 (12%)
Query: 254 LASTYQDILYQAKQDKMTNAKNRTENSERE---RDVYEELLTQAEIQGNINKVNTFSALA 310
L + QDI Q +D+ + AK + + + E +D EEL QA T L
Sbjct: 1519 LEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQA---------GTIQMLE 1569
Query: 311 NIDLALEQGDALALFRALQSPALGLRGLQ----QQNSDWYLKQLLSDKQQKRQSGQTDPL 366
L LE + R S + R + +Q+ LKQ+ +++ + Q
Sbjct: 1570 QAKLRLEM--EMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR 1627
Query: 367 QKEELQSGV----DAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVY 422
+K EL+ + D N + ++RL + ++T L + + L +
Sbjct: 1628 EKRELEGKLATLSDQVNRRDFESEKRL-----------RKDLKRTKALLADAQLMLDHLK 1676
Query: 423 PFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSS 482
A ++E+A L+ Q E T +V V + + L+ D+ L
Sbjct: 1677 NSAPS--KREIAQLKNQLEESEFTCAA-AVKARKAMEVEIEDLHLQIDDIAKAKTALEEQ 1733
Query: 483 VTGLTNIEEE------NCQRYLDELMKLKAQAHAE-NNEFITWNDIQACVDHVNLVVQEE 535
++ L + E Q ++ELMK A A+ + + ND+QA ++ N QE
Sbjct: 1734 LSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQEL 1793
Query: 536 HERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQ 595
E++ A+ E L++ K+L + Q AK+ + E ++ T ++ A ++
Sbjct: 1794 QEKLQALQSQVEFLEQSMVDKSLVSRQ--EAKIREL--ETRLEFERTQVKRLESLASRLK 1849
Query: 596 DESAVLWLDEIQGGIWQSNKDTQEAQK 622
+ L +E I N++ ++ ++
Sbjct: 1850 ENMEKL-TEERDQRIAAENREKEQNKR 1875
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 51.6 bits (122), Expect = 6e-06
Identities = 143/682 (20%), Positives = 265/682 (38%), Gaps = 115/682 (16%)
Query: 404 AEKTVLELMNPEAQLPQVYPFAADLYQK----ELATLQRQSPEHNLTHPELSVAVEMLSS 459
AE+ +L L N QVY A+L K E L +S E L E + E +
Sbjct: 1583 AEEKILTLEN------QVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636
Query: 460 VALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDEL----MKLKAQAHAENNEF 515
+A + R E + + KQL S + ++ + +L EL + + + H +
Sbjct: 1637 LAELKRKAEQ-KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKL 1695
Query: 516 ITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKT----LQALQIPAAKLEGV 571
+ Q+ L+V + + A EA +G QKT + LQ + E +
Sbjct: 1696 KSVESSQS----ETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 572 LAEVAQH--------------YQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDT 617
L V Q YQ+ LI+ + +A++ +D+S + +Q + + NK
Sbjct: 1752 LQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI---GHLQEELEEKNK-- 1806
Query: 618 QEAQKFALGIFAINEAVESG---------------DVGKTLSALRSPDVGLYGVIPECGE 662
K++L I A + E G DV KTL L I E
Sbjct: 1807 ----KYSL-IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
Query: 663 TYHSDLAEAKKKKLAVGDNNSKWVKHWV--------KGGYYYYHNLETQEGGWDEPPNFV 714
+ + + ++ + + SK+ K K N E + P +
Sbjct: 1862 CL---VRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLL 1918
Query: 715 QNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKK 774
N M+ +++ ++G RE+ L E I RLQ R ++R+E + + LKK
Sbjct: 1919 SN-MEAQHNDLEFKLAGA----EREKQKLGKE--IVRLQKDLR--MLRKEHQQELEILKK 1969
Query: 775 QIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRD 834
+ Q R K K+ +D L + +K Q ++ ++ ++
Sbjct: 1970 E-------YDQEREEKIKQEQED----LELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018
Query: 835 HINDIIKIQAFIRANKARDD---YKTLINAEDPPMVVVRKFVHLLDQSDQDFQEEL-DLM 890
IN +++A + + + K + +D +++ +LD +++ ++ DL
Sbjct: 2019 TINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQ 2078
Query: 891 KMREEVITLIRSNQQLENDLN-------LMDIKIGLLVKNKITLQDVVSHSKKLTKKNKE 943
EE+ + Q+LE + N +M+++ L K + +S SK ++ +E
Sbjct: 2079 TQLEELQK--KYQQKLEQEENPGNDNVTIMELQTQLAQKTTL-----ISDSKLKEQEFRE 2131
Query: 944 QLSDMM-MINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPT---YLAKLIFQMPQNKST 999
Q+ ++ + K + + A + K H L PT YL K++F+ + T
Sbjct: 2132 QIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRET 2191
Query: 1000 KFMDSVIFTLYNYASNQREEYL 1021
K M VI T+ + +Q ++ L
Sbjct: 2192 KTMAKVITTVLKFPDDQTQKIL 2213
Score = 42.4 bits (98), Expect = 0.004
Identities = 152/841 (18%), Positives = 322/841 (38%), Gaps = 145/841 (17%)
Query: 224 INEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAK-QDKMTNAKNRT----- 277
++E R DT + + + ++E S ++ L+++ ++ + +R
Sbjct: 46 LDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRL 105
Query: 278 --ENSERERDVYEELLTQAE-IQGN---INKVNTFSALANIDLALEQ-----GDALALFR 326
++S D ++ ++AE + GN +NK L ++ +L + + ++
Sbjct: 106 DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165
Query: 327 ALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQ 386
LQ L+G+ Q+ D L+++ + R+ Q D K+ LQ DA+ QY
Sbjct: 166 MLQREKKKLQGILSQSQDKSLRRI----AELREELQMDQQAKKHLQEEFDASLEEKDQYI 221
Query: 387 RRL-AAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNL 445
L V+L+ ++ G VL+ LPQ+ P A+++ KE ++PE +
Sbjct: 222 SVLQTQVSLLKQRLRNGPMNVDVLK------PLPQLEP-QAEVFTKE------ENPESD- 267
Query: 446 THPELSVAVEMLSSVALINRALESGDVNTVWKQLSSS----VTGLTNIEE---ENCQRYL 498
P + + + L R ++ K+ S T LT+ +E E L
Sbjct: 268 GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERL 327
Query: 499 DELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTL 558
EL K+K AE + IT D NL+ Q E ++ + I + E TL
Sbjct: 328 QELEKIKDLHMAEKTKLIT-----QLRDAKNLIEQLEQDKGMVIAETKRQMHE-----TL 377
Query: 559 QALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQ 618
+ + A+L + ++ ++ +R ++EK++ +E++ + + K +
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEE--LREQKEKSERAA-------FEELEKALSTAQKTEE 428
Query: 619 EAQKFALGIFAINEAVESGDVGKTLS---ALRSPDVGLYGVIPECGETYHSDLAEAKKKK 675
+K + + +E + +S L + V+ + E + L + +K+
Sbjct: 429 ARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKE 488
Query: 676 LAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQ-----LSRE-EIQSSI 729
LA + L+T+E + E Q +S+E E Q S+
Sbjct: 489 LARKEQE-------------LTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL 535
Query: 730 SGVTAAYNREQLWLANEGLITRLQARCRGYLVR------------QEFRSRMNFLKKQIP 777
+ ++ + +E + LQ Y R QE +++ L +
Sbjct: 536 ALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLE 595
Query: 778 A---------ITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKR---- 824
A ++ + K QD L + K +V+K Q M + R++
Sbjct: 596 AEKNKHNKEITVMVEKHKTELESLKHQQDA---LWTEKLQVLKQQYQTEMEKLREKCEQE 652
Query: 825 ----YRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSD 880
+D+ F+ HI ++ + + + D +T + + + V K H L++
Sbjct: 653 KETLLKDKEIIFQAHIEEMNE-----KTLEKLDVKQTELESLSSELSEVLKARHKLEEEL 707
Query: 881 QDFQEELDLMK---------------------MREEVITLIRSNQQLENDLNLMDIKIGL 919
+++ D MK ++E +++ R+ + L++ +N +++ L
Sbjct: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL---L 764
Query: 920 LVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLL 979
L + L++ +H + L K ++ + + ++ E+ +AY+ L
Sbjct: 765 LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 980 Q 980
Q
Sbjct: 825 Q 825
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 49.7 bits (117), Expect = 2e-05
Identities = 107/526 (20%), Positives = 198/526 (37%), Gaps = 111/526 (21%)
Query: 748 LITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLR---- 803
LITR QARCRG+L R E++ + ++ AI CIQ R + K + + +
Sbjct: 790 LITRTQARCRGFLARVEYQR----MVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPL 845
Query: 804 -----------SHKDEVVKIQ-SLARMHQARKRYRDRLQYFRDHINDI------------ 839
+ K+E KI+ LA+ RK +++ ND+
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 840 -------------IKIQAFIRANKARDDYKTLINAE----------------------DP 864
I+++A I+ R + + INAE +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 865 PMVVVRKFVHLLDQSDQDFQEEL-----DLMKMREEVITLIRSNQQLENDLNLMDIKIGL 919
+ V K H + ++ EE+ + K+ +E L ++QQ +DL + K+
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 920 LVKNKITLQDVVSHSKKLTKKNKEQLSDMMMI-NKQKGGLKA-------LSKEKR---EK 968
L K KI L+ V + ++ K+ D+ K +G LK + EK+ EK
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 969 LEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKT 1028
L+ + LQ+ L Q+ K K + + I L +R ++
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQL--QKKIKELQARIEELEEEIEAERASRAKAEKQRS 1143
Query: 1029 ALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIK 1088
L E++ ++++E G T ++ ++ R A Q R +++ +L +
Sbjct: 1144 DLSRELEEISERLEE--AGGATSAQIEMNKKREAEFQKMRRD---------LEEATLQHE 1192
Query: 1089 TDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSA 1148
+ K + + + L + VK +L+ M+ D L++
Sbjct: 1193 ATAATLRKKHADSVAELGEQIDNL------------QRVKQKLEKEKSEMKMEIDD-LAS 1239
Query: 1149 IVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYR 1194
V +V K + + + L+D L E + E+E ++I +L R
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQLSEL--KSKEEEQQRLINDLTAQR 1283
Score = 39.3 bits (90), Expect = 0.032
Identities = 163/881 (18%), Positives = 333/881 (37%), Gaps = 163/881 (18%)
Query: 174 KVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDE--AALHAAVIAINEAIDRR 231
K D + E+ K E EK+ + +K+ + +DE A L A+ EA +
Sbjct: 957 KKDIDDLELTLAKVEKEKHATE----NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012
Query: 232 IPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDK-----MTNAKNRTENS------ 280
+ D A ++ L + L D+ +Q+K + AK + E
Sbjct: 1013 L--DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
Query: 281 -----ERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGL 335
E E+ +E L + E + ++N+ +E AL + + L
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFE-----------ISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 336 RGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQK--EELQSGVDAANSAAQQYQRRLAAVA 393
R +++ + ++ K +K++S + L++ E L+ A ++ + ++R A
Sbjct: 1120 R-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178
Query: 394 LINAAIQKGVA--EKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELS 451
+ +++ E T L A D Q+ L+++ E + +L+
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 452 VAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAE 511
VE +S G++ + + L ++ L + EEE QR +++L + + E
Sbjct: 1239 SNVETVSKA--------KGNLEKMCRTLEDQLSELKSKEEEQ-QRLINDLTAQRGRLQTE 1289
Query: 512 NNEFITWND------------IQACVDHVNLVVQEEHERILAIGLINEALDEG------- 552
+ EF D QA + + ++ E I A + AL
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349
Query: 553 -----DAQKTLQALQIPAAKLEGVLAEVAQHYQ-------DTLIRAKREKAQEIQDESAV 600
+ Q++ LQ +K +A+ Y+ + L AK++ AQ +Q +A
Sbjct: 1350 REQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ--AAE 1407
Query: 601 LWLDEIQGGIWQSNKDTQ----EAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGV 656
++ + K Q E + L + N A + D R+ D L
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD-----KKQRNFDKILAEW 1462
Query: 657 IPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQN 716
+C ET H++L ++K+ ++G K +K Y +L+ E E N Q
Sbjct: 1463 KQKCEET-HAELEASQKEARSLGTELFK-----IKNA--YEESLDQLETLKRENKNLQQE 1514
Query: 717 SMQLSRE-----------------------EIQSSISGVTAAYNREQLWLANEGLITRLQ 753
L+ + E+Q+++ A+ E EG I R+Q
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHE------EGKILRIQ 1568
Query: 754 ARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEV---- 809
V+ E ++ ++I + ++ R + ++ D A +RS D +
Sbjct: 1569 LELN--QVKSEVDRKIAEKDEEIDQLK--RNHIRIVESMQSTLD--AEIRSRNDAIRLKK 1622
Query: 810 ----------VKIQSLARM-HQARKRYRDRLQYFRD---HINDIIKIQAFIRANKARDDY 855
+++ RM +A + YR+ +D H++D ++ Q ++ A +
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 856 K-TLINAEDPPMVVVRKFVHLLDQSDQDFQ-EELDLMKMREEVITLIRSNQQLENDLNLM 913
+ L+ AE + + L+Q+++ + E +L+ E V L N L N +
Sbjct: 1683 RANLLQAE------IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 914 DIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQ 954
+ I + + ++D++ ++ +K K+ ++D M+ ++
Sbjct: 1737 ETDISQM---QGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 49.7 bits (117), Expect = 2e-05
Identities = 107/526 (20%), Positives = 198/526 (37%), Gaps = 111/526 (21%)
Query: 748 LITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLR---- 803
LITR QARCRG+L R E++ + ++ AI CIQ R + K + + +
Sbjct: 790 LITRTQARCRGFLARVEYQR----MVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPL 845
Query: 804 -----------SHKDEVVKIQ-SLARMHQARKRYRDRLQYFRDHINDI------------ 839
+ K+E KI+ LA+ RK +++ ND+
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 840 -------------IKIQAFIRANKARDDYKTLINAE----------------------DP 864
I+++A I+ R + + INAE +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 865 PMVVVRKFVHLLDQSDQDFQEEL-----DLMKMREEVITLIRSNQQLENDLNLMDIKIGL 919
+ V K H + ++ EE+ + K+ +E L ++QQ +DL + K+
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 920 LVKNKITLQDVVSHSKKLTKKNKEQLSDMMMI-NKQKGGLKA-------LSKEKR---EK 968
L K KI L+ V + ++ K+ D+ K +G LK + EK+ EK
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 969 LEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKT 1028
L+ + LQ+ L Q+ K K + + I L +R ++
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQL--QKKIKELQARIEELEEEIEAERASRAKAEKQRS 1143
Query: 1029 ALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIK 1088
L E++ ++++E G T ++ ++ R A Q R +++ +L +
Sbjct: 1144 DLSRELEEISERLEE--AGGATSAQIEMNKKREAEFQKMRRD---------LEEATLQHE 1192
Query: 1089 TDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSA 1148
+ K + + + L + VK +L+ M+ D L++
Sbjct: 1193 ATAATLRKKHADSVAELGEQIDNL------------QRVKQKLEKEKSEMKMEIDD-LAS 1239
Query: 1149 IVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYR 1194
V +V K + + + L+D L E + E+E ++I +L R
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQLSEL--KSKEEEQQRLINDLTAQR 1283
Score = 39.3 bits (90), Expect = 0.032
Identities = 163/881 (18%), Positives = 333/881 (37%), Gaps = 163/881 (18%)
Query: 174 KVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDE--AALHAAVIAINEAIDRR 231
K D + E+ K E EK+ + +K+ + +DE A L A+ EA +
Sbjct: 957 KKDIDDLELTLAKVEKEKHATE----NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012
Query: 232 IPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDK-----MTNAKNRTENS------ 280
+ D A ++ L + L D+ +Q+K + AK + E
Sbjct: 1013 L--DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
Query: 281 -----ERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGL 335
E E+ +E L + E + ++N+ +E AL + + L
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFE-----------ISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 336 RGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQK--EELQSGVDAANSAAQQYQRRLAAVA 393
R +++ + ++ K +K++S + L++ E L+ A ++ + ++R A
Sbjct: 1120 R-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178
Query: 394 LINAAIQKGVA--EKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELS 451
+ +++ E T L A D Q+ L+++ E + +L+
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 452 VAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAE 511
VE +S G++ + + L ++ L + EEE QR +++L + + E
Sbjct: 1239 SNVETVSKA--------KGNLEKMCRTLEDQLSELKSKEEEQ-QRLINDLTAQRGRLQTE 1289
Query: 512 NNEFITWND------------IQACVDHVNLVVQEEHERILAIGLINEALDEG------- 552
+ EF D QA + + ++ E I A + AL
Sbjct: 1290 SGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLL 1349
Query: 553 -----DAQKTLQALQIPAAKLEGVLAEVAQHYQ-------DTLIRAKREKAQEIQDESAV 600
+ Q++ LQ +K +A+ Y+ + L AK++ AQ +Q +A
Sbjct: 1350 REQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ--AAE 1407
Query: 601 LWLDEIQGGIWQSNKDTQ----EAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGV 656
++ + K Q E + L + N A + D R+ D L
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD-----KKQRNFDKILAEW 1462
Query: 657 IPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQN 716
+C ET H++L ++K+ ++G K +K Y +L+ E E N Q
Sbjct: 1463 KQKCEET-HAELEASQKEARSLGTELFK-----IKNA--YEESLDQLETLKRENKNLQQE 1514
Query: 717 SMQLSRE-----------------------EIQSSISGVTAAYNREQLWLANEGLITRLQ 753
L+ + E+Q+++ A+ E EG I R+Q
Sbjct: 1515 ISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHE------EGKILRIQ 1568
Query: 754 ARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEV---- 809
V+ E ++ ++I + ++ R + ++ D A +RS D +
Sbjct: 1569 LELN--QVKSEVDRKIAEKDEEIDQLK--RNHIRIVESMQSTLD--AEIRSRNDAIRLKK 1622
Query: 810 ----------VKIQSLARM-HQARKRYRDRLQYFRD---HINDIIKIQAFIRANKARDDY 855
+++ RM +A + YR+ +D H++D ++ Q ++ A +
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVER 1682
Query: 856 K-TLINAEDPPMVVVRKFVHLLDQSDQDFQ-EELDLMKMREEVITLIRSNQQLENDLNLM 913
+ L+ AE + + L+Q+++ + E +L+ E V L N L N +
Sbjct: 1683 RANLLQAE------IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1736
Query: 914 DIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQ 954
+ I + + ++D++ ++ +K K+ ++D M+ ++
Sbjct: 1737 ETDISQM---QGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 49.3 bits (116), Expect = 3e-05
Identities = 169/848 (19%), Positives = 346/848 (40%), Gaps = 127/848 (14%)
Query: 161 KLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAA 220
K + IQDL ++D EEE K +LEK + A +KI + L +++ ++
Sbjct: 945 KKKMQAHIQDLEEQLD--EEEGARQKLQLEK----VTAEAKIKKMEEEILLLEDQ--NSK 996
Query: 221 VIAINEAIDRRIP------ADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAK 274
I + ++ RI A+ KN A + N +E + S ++ L + ++ + K
Sbjct: 997 FIKEKKLMEDRIAECSSQLAEEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEK 1055
Query: 275 NRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDL--ALEQGD--------ALAL 324
+ + D+ +++ AE+Q I+++ A +L AL +GD AL +
Sbjct: 1056 AKRKLDGETTDLQDQI---AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112
Query: 325 FRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQ 384
R LQ+ + LQ+ + ++KQ++ S + + L K EL+ +D + +
Sbjct: 1113 VRELQAQ---IAELQEDFESEKASRNKAEKQKRDLSEELEAL-KTELEDTLDTTAAQQEL 1168
Query: 385 YQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHN 444
+R VA + A+++ E N EAQ+ D+ Q+ L+ S +
Sbjct: 1169 RTKREQEVAELKKALEE--------ETKNHEAQIQ-------DMRQRHATALEELSEQ-- 1211
Query: 445 LTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNI--EEENCQRYLDELM 502
L A +++ + LE+ + K+L+ V L + E E+ ++ LD +
Sbjct: 1212 -----LEQAKRFKANLEKNKQGLETDN-----KELACEVKVLQQVKAESEHKRKKLDAQV 1261
Query: 503 KLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL-AIGLINEALDEGDAQKTLQAL 561
+ + HA+ +E D + + + E+ ++ + ++ L+E A+K
Sbjct: 1262 Q---ELHAKVSEG----------DRLRVELAEKASKLQNELDNVSTLLEE--AEKKGIKF 1306
Query: 562 QIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQ 621
AA LE L QDT + E Q++ S + L+E + + + ++ +EA+
Sbjct: 1307 AKDAASLESQL-------QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359
Query: 622 KFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDN 681
K ++ K + AL+S + + T S L EAKKK L +
Sbjct: 1360 K---------------NLEKQVLALQSQLADTKKKVDDDLGTIES-LEEAKKKLLKDAEA 1403
Query: 682 NSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQL 741
S+ ++ Y LE + + + + + + + S + +
Sbjct: 1404 LSQRLEEKALA----YDKLEKTKNRLQQE----LDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 742 WLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAY 801
LA E I+ A R + L ++++ +Q K + +
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 802 LRSHKDEVVK-----IQSLARMHQARKRYRDRLQYFRDHINDI----IKIQAFIRANKAR 852
L S KD+V K +S + Q + R +L+ D + ++++ ++A KA+
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575
Query: 853 DDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNL 912
+ + L ++ R + + + + + ++E R++ + S +++E DL
Sbjct: 1576 FE-RDLQTRDEQNEEKKRLLIKQVRELEAELEDE------RKQRALAVASKKKMEIDLK- 1627
Query: 913 MDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAY 972
D++ + NK +V+ +KL + K+ ++ + + A SKE +KL++
Sbjct: 1628 -DLEAQIEAANK-ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685
Query: 973 QHLFYLLQ 980
+ LQ
Sbjct: 1686 EAEILQLQ 1693
Score = 39.7 bits (91), Expect = 0.025
Identities = 54/288 (18%), Positives = 114/288 (39%), Gaps = 59/288 (20%)
Query: 735 AYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKA 794
A+ E+ L +I QA CRGYL R+ F + ++Q+ A+ +Q Y + +
Sbjct: 776 AHLEEERDLKITDIIIFFQAVCRGYLARKAFAKK----QQQLSALKVLQRNCAAYLKLRH 831
Query: 795 YQDRLAY---------------LRSHKDEVVKI-----------QSLARMHQA----RKR 824
+Q + L++ +E++K+ + + R HQ +
Sbjct: 832 WQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI 891
Query: 825 YRDRLQYFRDHINDIIKIQAFIRANKAR-----DDYKTLINAEDPPMVVVRKFVHLLDQS 879
++LQ + + +++A + A K D ++ + E+ +++ +
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 880 DQDFQEELD-------------------LMKMREEVITLIRSNQQLENDLNLMDIKIGLL 920
QD +E+LD + KM EE++ L N + + LM+ +I
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 921 VKNKITLQDVVSHSKKLTKKNKEQLSDM-MMINKQKGGLKALSKEKRE 967
++ + K+ K + +SD+ + K++ + L K KR+
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 49.3 bits (116), Expect = 3e-05
Identities = 39/168 (23%), Positives = 77/168 (45%), Gaps = 9/168 (5%)
Query: 1110 SKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKD 1169
SK +++P + +E+V T L + + + +K A + +P +R+I L+
Sbjct: 824 SKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS----EILPPTLRYIYGCLQK 879
Query: 1170 SLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIA 1229
S+ K+P +++ ++ R + PAI+ P F+II S + R L +A
Sbjct: 880 SVQHKWP-TNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSP----SPIAARTLILVA 934
Query: 1230 KMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQD 1277
K +Q+ A+ F ++ +N ++ + + F +VPEL D
Sbjct: 935 KSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPD 982
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 49.3 bits (116), Expect = 3e-05
Identities = 39/168 (23%), Positives = 77/168 (45%), Gaps = 9/168 (5%)
Query: 1110 SKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKD 1169
SK +++P + +E+V T L + + + +K A + +P +R+I L+
Sbjct: 647 SKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS----EILPPTLRYIYGCLQK 702
Query: 1170 SLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIA 1229
S+ K+P +++ ++ R + PAI+ P F+II S + R L +A
Sbjct: 703 SVQHKWP-TNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSP----SPIAARTLILVA 757
Query: 1230 KMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQD 1277
K +Q+ A+ F ++ +N ++ + + F +VPEL D
Sbjct: 758 KSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPD 805
>gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo
sapiens]
Length = 1487
Score = 47.4 bits (111), Expect = 1e-04
Identities = 67/342 (19%), Positives = 145/342 (42%), Gaps = 30/342 (8%)
Query: 971 AYQHLFYLLQTNPTYLAKLIF---QMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFK 1027
AY L+ NP +A + ++ Q + + +V +LY Q +E LL++ +
Sbjct: 95 AYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLR 154
Query: 1028 TALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNAL--RQILAPVVKEIMDDKSL 1085
++ E+K + + + G + F+ G + P+++ +++D+
Sbjct: 155 YLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDED- 213
Query: 1086 NIKTDPVDIYKSW-VNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDK 1144
+++TDP + + + +Q E GE + ++V+ ++S+ + A+ +K
Sbjct: 214 HLETDPNKLIERFSPSQQEKLFGEKGSDRF---------RQKVQEMVESNEAKLVALVNK 264
Query: 1145 FLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGE-DELLKIIGNLLYYRYMNPAIVAP 1203
F+ + + P+ +R+I + +L D E E+ + +LL ++ PA+V P
Sbjct: 265 FIGYLKQNTYCFPHSLRWIVSQMYKTL--SCVDRLEVGEVRAMCTDLLLACFICPAVVNP 322
Query: 1204 DAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFR 1263
+ + II + + R NL + ++LQ A GD S + ++ F
Sbjct: 323 EQYGII---SDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFL 379
Query: 1264 RFF--QTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEII 1303
A + P L + L L++ V+YI+ ++I
Sbjct: 380 DVVIGGRAVETPPL------SSVNLLEGLSRTVVYITYSQLI 415
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 47.4 bits (111), Expect = 1e-04
Identities = 62/285 (21%), Positives = 109/285 (38%), Gaps = 72/285 (25%)
Query: 748 LITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLR---- 803
LITR QA CRG+L+R EFR M ++ +I CIQ R + K + Y +
Sbjct: 788 LITRTQAICRGFLMRVEFRKMM----ERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPL 843
Query: 804 -----------SHKDEVVKI-QSLARMHQARKRYRDRLQYFRDHINDI------------ 839
+ K+E K + LA+ RK +++ ND+
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALA 903
Query: 840 -------------IKIQAFIRANKARDDYKTLINAE----------------------DP 864
I+++A I+ R + + INAE +
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 865 PMVVVRKFVHLLDQSDQDFQEEL-----DLMKMREEVITLIRSNQQLENDLNLMDIKIGL 919
+ V K H + ++ EE+ + K+ +E L ++QQ +DL + + K+
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNT 1023
Query: 920 LVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKE 964
L K K L+ V + ++ K+ D+ ++ G L++E
Sbjct: 1024 LTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Score = 40.0 bits (92), Expect = 0.019
Identities = 87/472 (18%), Positives = 193/472 (40%), Gaps = 54/472 (11%)
Query: 174 KVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDE--AALHAAVIAINEAIDRR 231
K D + E+ K E EK+ + +K+ + +DE A L A+ EA +
Sbjct: 955 KKDIDDLELTLAKVEKEKHATE----NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 232 IPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDK----------------MTNAKN 275
+ D ++ L + L D+ +Q+K + A+
Sbjct: 1011 L--DDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Query: 276 RTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGL 335
T ++E ++ E L + E + ++N+ +E ALA+ + L
Sbjct: 1069 STMDTENDKQQLNEKLKKKEFE-----------MSNLQGKIEDEQALAIQLQKKIKELQA 1117
Query: 336 RGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQK--EELQSGVDAANSAAQQYQRRLAAVA 393
R +++ + ++ K +K++S + L++ E L+ A ++ + ++R A
Sbjct: 1118 R-IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176
Query: 394 LINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVA 453
+ + E++ L+ A L + + + +++ +LQR + EL +
Sbjct: 1177 KMRRDL-----EESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKME 1231
Query: 454 V-EMLSSVALINRALESGD--VNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHA 510
+ ++ S++ +++A + + T+ QLS T +EE QR ++EL KA+ H
Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSEIKT-----KEEEQQRLINELSAQKARLHT 1286
Query: 511 ENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEG 570
E+ EF D + + V+ + + + I + L+E K+ A + +A+ +
Sbjct: 1287 ESGEFSRQLDEKDAM--VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDC 1344
Query: 571 VLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQK 622
L Q+ ++ +A+ ++ + W + + Q ++ +EA+K
Sbjct: 1345 DLLR-EQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Score = 35.8 bits (81), Expect = 0.35
Identities = 83/436 (19%), Positives = 159/436 (36%), Gaps = 58/436 (13%)
Query: 179 EEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFA 238
E E M+ +LE+ +Q A + + D A I + + +++ +
Sbjct: 1172 EAEFQKMRRDLEESTLQHEATAAA----LRKKHADSVAELGEQIDSLQRVKQKLEKEKSE 1227
Query: 239 ALKNPNAMLVNLEE-PLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQ 297
N + N+E A + + + +D+++ K + E +R + EL Q
Sbjct: 1228 LKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQR---LINELSAQ---- 1280
Query: 298 GNINKVNTFSALANIDLALEQGDALA--LFRALQSPALGLRGLQQQ-NSDWYLKQLLSDK 354
K + L++ DA+ L R Q+ + L++Q + K L+
Sbjct: 1281 ----KARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHA 1336
Query: 355 QQK--------RQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEK 406
Q R+ + + K ELQ G+ ANS Q++ + A+ + +K
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 407 TVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSS--VALIN 464
L + E + V A L +K LQ + +L + VE ++ +AL
Sbjct: 1397 LAQRLQDAEEHVEAVNSKCASL-EKTKQRLQNEV-------EDLMIDVERSNAACIALDK 1448
Query: 465 RALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQAC 524
+ V WKQ ++ + EL K+K N +
Sbjct: 1449 KQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVK-------------NAYEES 1495
Query: 525 VDHVNLVVQEEHERILAIGLINEALDEG-----DAQKTLQALQIPAAKLEGVLAEV---A 576
+DH+ + +E I + E + EG + +K + L ++L+ L E
Sbjct: 1496 LDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL 1555
Query: 577 QHYQDTLIRAKREKAQ 592
+H + ++R + E Q
Sbjct: 1556 EHEEGKILRIQLELNQ 1571
Score = 33.5 bits (75), Expect = 1.8
Identities = 59/283 (20%), Positives = 114/283 (40%), Gaps = 30/283 (10%)
Query: 806 KDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPP 865
K E IQ + +A+K+ RLQ +H+ + A + K R L N +
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQR-----LQNEVEDL 1432
Query: 866 MVVVRK---FVHLLDQSDQDFQEELDLMKMR-EEVITLIRSNQQLENDLNLMDIKIGLLV 921
M+ V + LD+ ++F + L K + EE + ++Q+ L+ L
Sbjct: 1433 MIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTE------LF 1486
Query: 922 KNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQ--KGG---------LKALSKEKREKLE 970
K K ++ + H + L ++NK ++ + +Q +GG K L EK E
Sbjct: 1487 KVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQT 1546
Query: 971 AYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYL-LLRLFKTA 1029
+ + L+ + ++ ++ Q KS +D I + +L ++ ++
Sbjct: 1547 SLEEAEASLEHEEGKILRIQLELNQVKSE--IDRKIAEKDEELDQLKRNHLRVVESMQST 1604
Query: 1030 LQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGAR-GQNALRQI 1071
L EI+S+ D ++ + +M + N R ALR +
Sbjct: 1605 LDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNL 1647
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 46.6 bits (109), Expect = 2e-04
Identities = 48/203 (23%), Positives = 90/203 (44%), Gaps = 24/203 (11%)
Query: 1036 SKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIY 1095
S+ + + N K V SF + A G L +L P++ ++ ++K ++ DP
Sbjct: 261 SRTSETNTLFRSNSLASKSVESFLKVA-GMQYLHGVLGPIINKVFEEKKY-VELDP---- 314
Query: 1096 KSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDK 1155
+++E + S L T + L + S + +RA LSA+ SV
Sbjct: 315 ----SKVEVKDVGCSGLHRPQTEAEVL---------EQSAQTLRAHLGALLSALSRSVRA 361
Query: 1156 IPYGMRFIAKVLKDSLHEKFPDAGEDELLKI-IGNLLYYRYMNPAIVAPDAFDIIDLSAG 1214
P +R + L + E+FP A + + I + + L R+ +PAI++P F + + A
Sbjct: 362 CPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHAD 421
Query: 1215 GQLTTDQRRNLGSIAKMLQHAAS 1237
+ + R L +AK +Q+ +
Sbjct: 422 ARTS----RTLLLLAKAVQNVGN 440
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 46.6 bits (109), Expect = 2e-04
Identities = 48/203 (23%), Positives = 90/203 (44%), Gaps = 24/203 (11%)
Query: 1036 SKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIY 1095
S+ + + N K V SF + A G L +L P++ ++ ++K ++ DP
Sbjct: 333 SRTSETNTLFRSNSLASKSVESFLKVA-GMQYLHGVLGPIINKVFEEKKY-VELDP---- 386
Query: 1096 KSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDK 1155
+++E + S L T + L + S + +RA LSA+ SV
Sbjct: 387 ----SKVEVKDVGCSGLHRPQTEAEVL---------EQSAQTLRAHLGALLSALSRSVRA 433
Query: 1156 IPYGMRFIAKVLKDSLHEKFPDAGEDELLKI-IGNLLYYRYMNPAIVAPDAFDIIDLSAG 1214
P +R + L + E+FP A + + I + + L R+ +PAI++P F + + A
Sbjct: 434 CPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHAD 493
Query: 1215 GQLTTDQRRNLGSIAKMLQHAAS 1237
+ + R L +AK +Q+ +
Sbjct: 494 ARTS----RTLLLLAKAVQNVGN 512
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 46.6 bits (109), Expect = 2e-04
Identities = 48/203 (23%), Positives = 90/203 (44%), Gaps = 24/203 (11%)
Query: 1036 SKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIY 1095
S+ + + N K V SF + A G L +L P++ ++ ++K ++ DP
Sbjct: 261 SRTSETNTLFRSNSLASKSVESFLKVA-GMQYLHGVLGPIINKVFEEKKY-VELDP---- 314
Query: 1096 KSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDK 1155
+++E + S L T + L + S + +RA LSA+ SV
Sbjct: 315 ----SKVEVKDVGCSGLHRPQTEAEVL---------EQSAQTLRAHLGALLSALSRSVRA 361
Query: 1156 IPYGMRFIAKVLKDSLHEKFPDAGEDELLKI-IGNLLYYRYMNPAIVAPDAFDIIDLSAG 1214
P +R + L + E+FP A + + I + + L R+ +PAI++P F + + A
Sbjct: 362 CPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHAD 421
Query: 1215 GQLTTDQRRNLGSIAKMLQHAAS 1237
+ + R L +AK +Q+ +
Sbjct: 422 ARTS----RTLLLLAKAVQNVGN 440
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 46.6 bits (109), Expect = 2e-04
Identities = 48/203 (23%), Positives = 90/203 (44%), Gaps = 24/203 (11%)
Query: 1036 SKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIY 1095
S+ + + N K V SF + A G L +L P++ ++ ++K ++ DP
Sbjct: 333 SRTSETNTLFRSNSLASKSVESFLKVA-GMQYLHGVLGPIINKVFEEKKY-VELDP---- 386
Query: 1096 KSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDK 1155
+++E + S L T + L + S + +RA LSA+ SV
Sbjct: 387 ----SKVEVKDVGCSGLHRPQTEAEVL---------EQSAQTLRAHLGALLSALSRSVRA 433
Query: 1156 IPYGMRFIAKVLKDSLHEKFPDAGEDELLKI-IGNLLYYRYMNPAIVAPDAFDIIDLSAG 1214
P +R + L + E+FP A + + I + + L R+ +PAI++P F + + A
Sbjct: 434 CPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHAD 493
Query: 1215 GQLTTDQRRNLGSIAKMLQHAAS 1237
+ + R L +AK +Q+ +
Sbjct: 494 ARTS----RTLLLLAKAVQNVGN 512
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 45.4 bits (106), Expect = 4e-04
Identities = 74/397 (18%), Positives = 170/397 (42%), Gaps = 42/397 (10%)
Query: 791 QKKAYQDRLAYLRSHKDEVVK--IQSLARMHQARKRYRDRLQYFRDHINDIIKIQ-AFIR 847
Q +A Q+ LA + + ++K IQ AR+ + +R + + + K++
Sbjct: 902 QLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFE 961
Query: 848 ANKARDDYKT-LINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQL 906
K DD +T L+ +E K +L ++ + F E D+ K+ + ++QQ
Sbjct: 962 LKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVE--FLNE-DISKLNRAAKVVQEAHQQT 1018
Query: 907 ENDLNLMDIKIGLLVKNKITLQDVVSHSK-KLTKKNKEQLSDMMMINKQKGGLKALSKEK 965
+DL++ + K+ L K + L+ V + L ++ K +++ ++K +G LK L++E
Sbjct: 1019 LDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLK-LNRES 1077
Query: 966 REKLEAYQ-HLFYLLQTNPTYLAKLIFQMPQ--------NKSTKFMDSVIFTLYNYASNQ 1016
E LE+ Q HL L+ L+++ ++ K+ K + + I L +
Sbjct: 1078 MENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAE 1137
Query: 1017 REEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVV 1076
R + + L +++ ++++E+ G ++ ++ ++ + + Q R
Sbjct: 1138 RTTRAKMERERADLTQDLADLNERLEEV--GGSSLAQLEITKKQETKFQKLHRD------ 1189
Query: 1077 KEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIR 1136
M++ +L+ +T + K + + G+ L ++VK +L+
Sbjct: 1190 ---MEEATLHFETTSASLKKRHADSLAELEGQVENL------------QQVKQKLEKDKS 1234
Query: 1137 NMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHE 1173
+++ D L+ V + + + + ++ LHE
Sbjct: 1235 DLQLEVDDLLTR-VEQMTRAKANAEKLCTLYEERLHE 1270
Score = 43.9 bits (102), Expect = 0.001
Identities = 106/471 (22%), Positives = 190/471 (40%), Gaps = 74/471 (15%)
Query: 169 QDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAI 228
QDL + EE + +LE Q F K+ ++EA LH A
Sbjct: 1153 QDLADLNERLEEVGGSSLAQLEITKKQETKFQKL------HRDMEEATLH---FETTSAS 1203
Query: 229 DRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQA-----KQDKMTNAKNRTENSERE 283
++ AD+ A L+ L +++ L D+ + + ++MT AK N+E+
Sbjct: 1204 LKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAK---ANAEKL 1260
Query: 284 RDVYEELLTQAEIQGNINKVNTFSALANIDLALEQ----GDALALFRALQSPALGLRGLQ 339
+YEE L +A K++ + LAN DLA ++ ++ R L+ + L
Sbjct: 1261 CTLYEERLHEATA-----KLDKVTQLAN-DLAAQKTKLWSESGEFLRRLEEKEALINQLS 1314
Query: 340 QQNSDWYLKQLLS-----DKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVAL 394
++ S+ + +Q+ +K+ K QS LQK + + +QY+ A
Sbjct: 1315 REKSN-FTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDL-----LREQYEEEQEVKAE 1368
Query: 395 INAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPE------------ 442
++ + K AE V M E + Q D +KELA +++ E
Sbjct: 1369 LHRTLSKVNAEM-VQWRMKYENNVIQRTEDLEDA-KKELAIRLQEAAEAMGVANARNASL 1426
Query: 443 ----HNLTHPELSVAVEMLSSVA-----LINRALESGDVNTVWKQLSSSVTGLTNIEEEN 493
H L EL A+ L V L + L+SG WKQ L + ++
Sbjct: 1427 ERARHQL-QLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKE 1485
Query: 494 CQRYLDELMKLK--AQAHAENNEFITW--NDIQACVDHVNLVVQEEHERILAIGLINEAL 549
Q EL+KLK + E + ++Q + ++ V+E + + + + + +
Sbjct: 1486 VQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLI 1545
Query: 550 DEGDAQKTLQALQIPAAKLEGVLAEVAQ---HYQDTLIRAKREKAQEIQDE 597
+E +KT +Q+ + EG L H+Q L+ AK E +++ ++
Sbjct: 1546 EE---EKT--EVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEK 1591
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 45.4 bits (106), Expect = 4e-04
Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 24/203 (11%)
Query: 1036 SKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIY 1095
S+ + + N K + SF + A G L +L P++ ++ ++K ++ DP
Sbjct: 333 SRTSETNTLFRSNSLASKSMESFLKVA-GMQYLHGVLGPIINKVFEEKKY-VELDP---- 386
Query: 1096 KSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDK 1155
+++E + S L T + L + S + +RA LSA+ SV
Sbjct: 387 ----SKVEVKDVGCSGLHRPQTEAEVL---------EQSAQTLRAHLGALLSALSRSVRA 433
Query: 1156 IPYGMRFIAKVLKDSLHEKFPDAGEDELLKI-IGNLLYYRYMNPAIVAPDAFDIIDLSAG 1214
P +R + L + E+FP A + + I + + L R+ +PAI++P F + + A
Sbjct: 434 CPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHAD 493
Query: 1215 GQLTTDQRRNLGSIAKMLQHAAS 1237
+ + R L +AK +Q+ +
Sbjct: 494 ARTS----RTLLLLAKAVQNVGN 512
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 45.4 bits (106), Expect = 4e-04
Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 24/203 (11%)
Query: 1036 SKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIY 1095
S+ + + N K + SF + A G L +L P++ ++ ++K ++ DP
Sbjct: 333 SRTSETNTLFRSNSLASKSMESFLKVA-GMQYLHGVLGPIINKVFEEKKY-VELDP---- 386
Query: 1096 KSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDK 1155
+++E + S L T + L + S + +RA LSA+ SV
Sbjct: 387 ----SKVEVKDVGCSGLHRPQTEAEVL---------EQSAQTLRAHLGALLSALSRSVRA 433
Query: 1156 IPYGMRFIAKVLKDSLHEKFPDAGEDELLKI-IGNLLYYRYMNPAIVAPDAFDIIDLSAG 1214
P +R + L + E+FP A + + I + + L R+ +PAI++P F + + A
Sbjct: 434 CPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHAD 493
Query: 1215 GQLTTDQRRNLGSIAKMLQHAAS 1237
+ + R L +AK +Q+ +
Sbjct: 494 ARTS----RTLLLLAKAVQNVGN 512
>gi|126116596 asp (abnormal spindle)-like, microcephaly associated
[Homo sapiens]
Length = 3477
Score = 45.1 bits (105), Expect = 6e-04
Identities = 40/128 (31%), Positives = 58/128 (45%), Gaps = 17/128 (13%)
Query: 725 IQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQS 784
IQ+ A N+ + +L + T LQA RGY VRQ +K+Q A IQS
Sbjct: 1781 IQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQ-------LIKQQSIAALKIQS 1833
Query: 785 QWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQA 844
+RGY ++ YQ L ++KIQ R ++A K D +F +I +Q+
Sbjct: 1834 AFRGYNKRVKYQSVL-------QSIIKIQ---RWYRAYKTLHDTRTHFLKTKAAVISLQS 1883
Query: 845 FIRANKAR 852
R K R
Sbjct: 1884 AYRGWKVR 1891
Score = 37.0 bits (84), Expect = 0.16
Identities = 37/130 (28%), Positives = 59/130 (45%), Gaps = 23/130 (17%)
Query: 752 LQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVK 811
LQA RG VR+ L+K A T IQS +R Y+Q + Y ++L +
Sbjct: 2173 LQASFRGVRVRRT-------LRKMQTAATLIQSNYRRYRQ-QTYFNKLKKI--------- 2215
Query: 812 IQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYK------TLINAEDPP 865
+++ + + A K + Q + + +I IQA R KAR K TLI
Sbjct: 2216 TKTVQQRYWAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRT 2275
Query: 866 MVVVRKFVHL 875
+++ R+F+ L
Sbjct: 2276 LMMRRRFLSL 2285
Score = 36.6 bits (83), Expect = 0.21
Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 15/101 (14%)
Query: 725 IQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQS 784
+Q+ +A ++ Q++L + +QAR +G++ +++F+ N K IQ+
Sbjct: 2889 LQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIK-------IQA 2941
Query: 785 QWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRY 825
WR Y+ KK YL K KIQ+ R +A K Y
Sbjct: 2942 MWRRYRAKK-------YLCKVK-AACKIQAWYRCWRAHKEY 2974
Score = 35.8 bits (81), Expect = 0.35
Identities = 56/247 (22%), Positives = 93/247 (37%), Gaps = 67/247 (27%)
Query: 697 YHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARC 756
Y+ + Q+ W M+ + IQ + + L+L + + LQ+
Sbjct: 1980 YYRMHVQQKKW--------KIMKKAALLIQKYYRAYSIGREQNHLYLKTKAAVVTLQSAY 2031
Query: 757 RGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQD------------RLAYLRS 804
RG VR+ +K A IQS++R YK KK Y R + +
Sbjct: 2032 RGMKVRKR-------IKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITN 2084
Query: 805 H--------KDEVVKIQSLAR----------MHQAR-------KRYRDRLQYF---RDHI 836
H K +KIQS+ R MH+A K ++ R+ Y + I
Sbjct: 2085 HQHKEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAI 2144
Query: 837 NDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEV 896
++ +A+ + R+ Y T++ A V +L S + + L KM +
Sbjct: 2145 VIQVRCRAYYQGKMQREKYLTILKA-----------VKVLQASFRGVRVRRTLRKM-QTA 2192
Query: 897 ITLIRSN 903
TLI+SN
Sbjct: 2193 ATLIQSN 2199
Score = 34.7 bits (78), Expect = 0.79
Identities = 23/88 (26%), Positives = 40/88 (45%), Gaps = 18/88 (20%)
Query: 752 LQARCRGYLVRQEF-----------RSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLA 800
+Q C+ + +R+ + R + A+ CIQS +RG+K +K Q+
Sbjct: 2631 IQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQN--- 2687
Query: 801 YLRSHKDEVVKIQSLARMHQARKRYRDR 828
H+ + IQS RMH+A+ Y +
Sbjct: 2688 ---MHRAATL-IQSFYRMHRAKVDYETK 2711
Score = 33.9 bits (76), Expect = 1.3
Identities = 40/176 (22%), Positives = 73/176 (41%), Gaps = 36/176 (20%)
Query: 725 IQSSISGVTAAYN-REQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQ 783
+QS I + A + + LW +Q R YL R++ + R LK + IQ
Sbjct: 1377 LQSRIRMIIAVTSYKRYLWAT-----VTIQRHWRAYLRRKQDQQRYEMLKS---STLIIQ 1428
Query: 784 SQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQ 843
S +R +KQ+K ++S V +Q R RK+ ++ N I IQ
Sbjct: 1429 SMFRKWKQRK--------MQSQVKATVILQRAFREWHLRKQAKEE--------NSAIIIQ 1472
Query: 844 AFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITL 899
++ R +K Y + +R V ++ + + FQ + + +E ++T+
Sbjct: 1473 SWYRMHKELRKY-----------IYIRSCVVIIQKRFRCFQAQKLYKRRKESILTI 1517
Score = 33.5 bits (75), Expect = 1.8
Identities = 75/373 (20%), Positives = 144/373 (38%), Gaps = 51/373 (13%)
Query: 736 YNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAY 795
+ ++L+ + I +Q + YL + R N+L+K+ AI +Q+ +R K
Sbjct: 1501 FQAQKLYKRRKESILTIQKYYKAYLKGKI--ERTNYLQKRAAAIQ-LQAAFRRLKAHNLC 1557
Query: 796 QDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDY 855
+ A IQS RM Q R R+ + + IIK QA +R ++ R Y
Sbjct: 1558 RQIRA--------ACVIQSYWRMRQDRVRFLNLKK-------TIIKFQAHVRKHQQRQKY 1602
Query: 856 KTLINAEDPPMVVVRKFVHLLD-----QSDQD----FQEELDLMKMREEVITLIRSNQQL 906
K + A R ++ + Q + Q M+ R+ I ++ S ++
Sbjct: 1603 KKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKI 1662
Query: 907 ENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKR 966
++ K L T++ + K T+K L + +Q K ++ +KR
Sbjct: 1663 QSYYRAYVSKKEFLSLKNATIKLQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKR 1722
Query: 967 E----------KLEAYQHLFYL-----LQTNPTYLAKLIFQMPQNKSTKF-MDSVIFTLY 1010
E KL+A+ + + LQ + F+M + + M I +
Sbjct: 1723 EEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQ 1782
Query: 1011 NY------ASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARG 1064
NY NQR+ +L ++ T LQ + ++++++ + S RG
Sbjct: 1783 NYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGY--KVRQLIKQQSIAALKIQSAFRGYNK 1840
Query: 1065 QNALRQILAPVVK 1077
+ + +L ++K
Sbjct: 1841 RVKYQSVLQSIIK 1853
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
Length = 1343
Score = 44.7 bits (104), Expect = 8e-04
Identities = 43/173 (24%), Positives = 76/173 (43%), Gaps = 25/173 (14%)
Query: 1180 EDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNK 1239
ED ++I L+ R++ PAI++P F ++ Q + R L IAK++Q+ A+
Sbjct: 582 EDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTS----RTLTLIAKVIQNLANFS 637
Query: 1240 MFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISI 1299
F L +NE+L + ++F ++ L + + + Y DL
Sbjct: 638 KFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGR---------- 687
Query: 1300 GEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPN 1352
E+ H LL + + P+ + E L LG +P L+ + S L +PN
Sbjct: 688 -ELSTLHALLWE----VLPQLS---KEALLKLGPLP---RLLNDISTALRNPN 729
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 44.7 bits (104), Expect = 8e-04
Identities = 61/291 (20%), Positives = 110/291 (37%), Gaps = 72/291 (24%)
Query: 748 LITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLR---- 803
LITR QA CRG+L R E++ + ++ +I CIQ R + K + Y +
Sbjct: 788 LITRTQAMCRGFLARVEYQK----MVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPL 843
Query: 804 -----------SHKDEVVKI-QSLARMHQARKRYRDRLQYFRDHINDI------------ 839
+ K+E K + LA+ RK +++ ND+
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903
Query: 840 -------------IKIQAFIRANKARDDYKTLINAE----------------------DP 864
I+++A I+ R + + INAE +
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 865 PMVVVRKFVHLLDQSDQDFQEEL-----DLMKMREEVITLIRSNQQLENDLNLMDIKIGL 919
+ V K H + ++ EE+ + K+ +E L ++QQ +DL + K+
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023
Query: 920 LVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLE 970
L K KI L+ V + ++ K+ D+ ++ G L++E +E
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIE 1074
Score = 33.1 bits (74), Expect = 2.3
Identities = 70/357 (19%), Positives = 143/357 (40%), Gaps = 35/357 (9%)
Query: 806 KDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPP 865
K E IQ + +A+K+ RLQ +H+ + A + K R L N +
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQR-----LQNEVEDL 1432
Query: 866 MVVVRK---FVHLLDQSDQDFQEELDLMKMR-EEVITLIRSNQQLENDLNLMDIKIGLLV 921
M+ V + LD+ ++F + L K + EE + ++Q+ L+ KI
Sbjct: 1433 MIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAY 1492
Query: 922 KNKITLQDVVSHSKKLTKKNKEQLSDM--------MMINKQKGGLKALSKEKREKLEAYQ 973
+ + D + K+ K ++++SD+ I++ + K + +EK E A +
Sbjct: 1493 EESL---DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALE 1549
Query: 974 HLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYL-LLRLFKTALQE 1032
L+ + ++ ++ Q KS +D I + ++ ++ ++ L
Sbjct: 1550 EAEASLEHEEGKILRIQLELNQVKSE--VDRKIAEKDEEIDQMKRNHIRIVESMQSTLDA 1607
Query: 1033 EIKSKVDQIQEIVTGNPTVIKMVVSFNRGAR-GQNALRQILAPVVKEIMDDKSLNIKTDP 1091
EI+S+ D I+ + +M + N R ALR + I+ D L++ D
Sbjct: 1608 EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN--TQAILKDTQLHL-DDA 1664
Query: 1092 VDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSA 1148
+ + Q+ A+ L ++ EE++ L+ + R+ + + L A
Sbjct: 1665 LRSQEDLKEQLAMVERRANLLQAEI--------EELRATLEQTERSRKIAEQELLDA 1713
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 44.3 bits (103), Expect = 0.001
Identities = 86/471 (18%), Positives = 183/471 (38%), Gaps = 93/471 (19%)
Query: 748 LITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLR---- 803
+ITR+QA+ RG L+R EF+ + ++ A+ IQ R + K + Y +
Sbjct: 786 IITRMQAQARGQLMRIEFKK----IVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPL 841
Query: 804 -----------SHKDEVVKIQSLARMHQARKRYRD---------------RLQYFRDHIN 837
+ K+E +I+ +AR++ + ++Q +D++N
Sbjct: 842 LKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 838 DI-----------IKIQAFIRANKARDDYKTLINAE----------------------DP 864
D I+++A ++ R + + +NAE +
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 865 PMVVVRKFVHLLDQSDQDFQEELD-----LMKMREEVITLIRSNQQLENDLNLMDIKIGL 919
+ V K H + ++ EE+ + K+ +E L ++QQ +DL + + K+
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021
Query: 920 LVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKE-----KREKLEAYQH 974
L K+K+ L+ V + ++ K+ D+ ++ G L++E + +KL+ +
Sbjct: 1022 LSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK 1081
Query: 975 L----FYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTAL 1030
L F + Q N + + + K K + I L +R + ++ L
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 1031 QEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTD 1090
E++ ++++E G T +++ ++ R A Q R + ++ +L K
Sbjct: 1142 SRELEEISERLEE--AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK-- 1197
Query: 1091 PVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAV 1141
+ V ++ Q ++ + E++ E K LD NM +
Sbjct: 1198 ----HADSVAELGEQIDNLQRVKQKLEKEKS----EFKLELDDVTSNMEQI 1240
Score = 32.7 bits (73), Expect = 3.0
Identities = 51/270 (18%), Positives = 96/270 (35%), Gaps = 39/270 (14%)
Query: 346 YLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAE 405
Y +Q+ K+Q + G+ LQS + +QY+ A A + + K +E
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 406 ----------------KTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPE 449
+ + E AQ Q A + + ++L++ +
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 450 LSVAVEM--LSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQ 507
L V VE ++ AL + + WKQ ++ + EL KLK
Sbjct: 1430 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK-- 1487
Query: 508 AHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEG-----DAQKTLQALQ 562
N + ++H+ +E I + E L EG + +K + L+
Sbjct: 1488 -----------NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLE 1536
Query: 563 IPAAKLEGVLAEV---AQHYQDTLIRAKRE 589
+ +L+ L E +H + ++RA+ E
Sbjct: 1537 VEKLELQSALEEAEASLEHEEGKILRAQLE 1566
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 44.3 bits (103), Expect = 0.001
Identities = 97/524 (18%), Positives = 193/524 (36%), Gaps = 107/524 (20%)
Query: 748 LITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLR---- 803
+ITR QA CRG+L+R E++ + ++ A+ CIQ R + K + + +
Sbjct: 787 IITRTQAVCRGFLMRVEYQKML----QRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPL 842
Query: 804 -----------SHKDEVVKIQ-SLARMHQARKRYRDRLQYFRDHINDI------------ 839
+ K+E K + LA+ RK +++ ND+
Sbjct: 843 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLA 902
Query: 840 -------------IKIQAFIRANKARDDYKTLINAE----------------------DP 864
I+++A I+ R + + INAE +
Sbjct: 903 DAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 865 PMVVVRKFVHLLDQSDQDFQEEL-----DLMKMREEVITLIRSNQQLENDLNLMDIKIGL 919
+ V K H + ++ EE+ + K+ +E L ++QQ +DL + K+ +
Sbjct: 963 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNI 1022
Query: 920 LVKNKITLQDVVSHSKKLTKKNKEQLSDMMMI-NKQKGGLKALSKEKREKLEAYQHLFYL 978
L K K L+ V + ++ K+ D+ K +G LK + + Q L
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 979 LQTNPTYLAKLI--------FQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTAL 1030
L+ ++ LI ++ K K + + I L +R ++ L
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142
Query: 1031 QEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTD 1090
E++ ++++E G T ++ ++ R A Q R +++ +L +
Sbjct: 1143 SRELEEISERLEE--AGGATSAQVELNKKREAEFQKLRRD---------LEEATLQHEAM 1191
Query: 1091 PVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIV 1150
+ K + M + L + VK +L+ ++ TD LS+
Sbjct: 1192 VAALRKKHADSMAELGEQIDNL------------QRVKQKLEKEKSELKMETDD-LSSNA 1238
Query: 1151 SSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYR 1194
++ K + + + L+D + E E+E ++I +L R
Sbjct: 1239 EAISKAKGNLEKMCRSLEDQVSEL--KTKEEEQQRLINDLTAQR 1280
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 43.5 bits (101), Expect = 0.002
Identities = 38/165 (23%), Positives = 73/165 (44%), Gaps = 19/165 (11%)
Query: 1185 KIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQR--RNLGSIAKMLQHAASNKMFL 1242
++I L+ R++ PAI++P F+++ Q D R R L IAK++Q+ A+ F
Sbjct: 471 RLISASLFLRFLCPAIMSPSLFNLM------QEYPDDRTSRTLTLIAKVIQNLANFAKFG 524
Query: 1243 GDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEI 1302
+++ +N++L + +RF + + + D Y DL E+
Sbjct: 525 NKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGR-----------EL 573
Query: 1303 INTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGN 1347
H+LL + + N + + LG +P + + I +S N
Sbjct: 574 SVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTN 618
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 43.5 bits (101), Expect = 0.002
Identities = 23/94 (24%), Positives = 53/94 (56%), Gaps = 10/94 (10%)
Query: 733 TAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQK 792
+AA + W A+ L+ R +++Q++R ++ +++ A CIQ++W+ Y++
Sbjct: 1076 SAAALLQASWRAHLERQRYLELRAAAIVIQQKWR---DYYRRRHMAAICIQARWKAYRES 1132
Query: 793 KAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYR 826
K YQ++ + +++ +QS R +AR+R++
Sbjct: 1133 KRYQEQ-------RKKIILLQSTCRGFRARQRFK 1159
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,682,381
Number of Sequences: 37866
Number of extensions: 2364976
Number of successful extensions: 9807
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 236
Number of HSP's that attempted gapping in prelim test: 8920
Number of HSP's gapped (non-prelim): 983
length of query: 1657
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1541
effective length of database: 13,855,062
effective search space: 21350650542
effective search space used: 21350650542
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.