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Search of human proteins with 4506067
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506067 protein kinase C, alpha [Homo sapiens]
(672 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506067 protein kinase C, alpha [Homo sapiens] 1407 0.0
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 1148 0.0
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 1118 0.0
gi|13384594 protein kinase C, gamma [Homo sapiens] 1041 0.0
gi|4885563 protein kinase C, epsilon [Homo sapiens] 590 e-168
gi|28557781 protein kinase C, eta [Homo sapiens] 404 e-112
gi|5453976 protein kinase C, theta [Homo sapiens] 387 e-107
gi|47157325 protein kinase C, delta [Homo sapiens] 375 e-104
gi|31377782 protein kinase C, delta [Homo sapiens] 375 e-104
gi|133908623 protein kinase C, iota [Homo sapiens] 373 e-103
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 364 e-100
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 364 e-100
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 364 e-100
gi|5453974 protein kinase N2 [Homo sapiens] 331 1e-90
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 322 9e-88
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 322 9e-88
gi|4502023 AKT2 kinase [Homo sapiens] 320 3e-87
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 317 2e-86
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 316 4e-86
gi|62241015 AKT1 kinase [Homo sapiens] 311 1e-84
gi|62241013 AKT1 kinase [Homo sapiens] 311 1e-84
gi|62241011 AKT1 kinase [Homo sapiens] 311 1e-84
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 299 5e-81
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 299 5e-81
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 299 5e-81
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 299 5e-81
gi|40254851 protein kinase PKNbeta [Homo sapiens] 298 1e-80
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 291 1e-78
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 291 1e-78
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 279 5e-75
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 1407 bits (3643), Expect = 0.0
Identities = 672/672 (100%), Positives = 672/672 (100%)
Query: 1 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF 60
MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
Sbjct: 1 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF 60
Query: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS 120
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
Sbjct: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS 120
Query: 121 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA 180
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
Sbjct: 121 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA 180
Query: 181 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL 240
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
Sbjct: 181 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL 240
Query: 241 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME 300
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
Sbjct: 241 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME 300
Query: 301 LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG 360
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
Sbjct: 301 LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG 360
Query: 361 TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV 420
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
Sbjct: 361 TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV 420
Query: 421 NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA 480
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
Sbjct: 421 NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA 480
Query: 481 DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG 540
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
Sbjct: 481 DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG 540
Query: 541 EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI 600
EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
Sbjct: 541 EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI 600
Query: 601 DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN 660
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
Sbjct: 601 DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN 660
Query: 661 PQFVHPILQSAV 672
PQFVHPILQSAV
Sbjct: 661 PQFVHPILQSAV 672
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 1148 bits (2969), Expect = 0.0
Identities = 543/676 (80%), Positives = 601/676 (88%), Gaps = 9/676 (1%)
Query: 1 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF 60
MAD G + ++ RFARKGALRQKNVHEVK+HKF ARFFKQPTFCSHCTDFIWGF
Sbjct: 1 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60
Query: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS 120
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGP +DDPRSKHKFKIHTY SPTFCDHCGS
Sbjct: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120
Query: 121 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA 180
LLYGLIHQGMKCDTC MNVHK+CV+NVPSLCG DHTE+RGRIY++A + + L V VRDA
Sbjct: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA 180
Query: 181 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL 240
KNL+PMDPNGLSDPYVKLKLIPDPK+ESKQKTKTI+ +LNP+WNE+F F+LK SDKDRRL
Sbjct: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240
Query: 241 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME 300
SVEIWDWD T+RNDFMGSLSFG+SEL K GW+KLL+QEEGEY+NVP+P E N E
Sbjct: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE 300
Query: 301 LRQKFEKAKLGPAGNKVISPSE------DRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 354
LRQKFE+AK+ G KV P E + + N DR+KLTDFNFLMVLGKGSFGKVM
Sbjct: 301 LRQKFERAKISQ-GTKV--PEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVM 357
Query: 355 LADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLY 414
L++RKGT+ELYA+KILKKDVVIQDDDVECTMVEKRVLAL KPPFLTQLHSCFQT+DRLY
Sbjct: 358 LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLY 417
Query: 415 FVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSE 474
FVMEYVNGGDLMYHIQQVG+FKEP AVFYAAEI+IGLFFL +GIIYRDLKLDNVMLDSE
Sbjct: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477
Query: 475 GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAG 534
GHIKIADFGMCKE++ DGVTT+TFCGTPDYIAPEIIAYQPYGKSVDWWA+GVLLYEMLAG
Sbjct: 478 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAG 537
Query: 535 QPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREH 594
Q PF+GEDEDELFQSIMEHNV+YPKS+SKEAV+ICKGLMTKHP KRLGCGPEGERD++EH
Sbjct: 538 QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597
Query: 595 AFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFE 654
AFFR IDWEKLE +EIQPP+KPK CG+ AENFD+FFTR PVLTPPDQ VI NIDQS+FE
Sbjct: 598 AFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFE 657
Query: 655 GFSYVNPQFVHPILQS 670
GFS+VN +F+ P ++S
Sbjct: 658 GFSFVNSEFLKPEVKS 673
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 1118 bits (2891), Expect = 0.0
Identities = 533/671 (79%), Positives = 588/671 (87%), Gaps = 10/671 (1%)
Query: 1 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF 60
MAD G + ++ RFARKGALRQKNVHEVK+HKF ARFFKQPTFCSHCTDFIWGF
Sbjct: 1 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60
Query: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS 120
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGP +DDPRSKHKFKIHTY SPTFCDHCGS
Sbjct: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120
Query: 121 LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA 180
LLYGLIHQGMKCDTC MNVHK+CV+NVPSLCG DHTE+RGRIY++A + + L V VRDA
Sbjct: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA 180
Query: 181 KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL 240
KNL+PMDPNGLSDPYVKLKLIPDPK+ESKQKTKTI+ +LNP+WNE+F F+LK SDKDRRL
Sbjct: 181 KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL 240
Query: 241 SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME 300
SVEIWDWD T+RNDFMGSLSFG+SEL K GW+KLL+QEEGEY+NVP+P E N E
Sbjct: 241 SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE 300
Query: 301 LRQKFEKAKLGPAGNKVISPSE------DRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVM 354
LRQKFE+AK+ G KV P E + + N DR+KLTDFNFLMVLGKGSFGKVM
Sbjct: 301 LRQKFERAKISQ-GTKV--PEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVM 357
Query: 355 LADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLY 414
L++RKGT+ELYA+KILKKDVVIQDDDVECTMVEKRVLAL KPPFLTQLHSCFQT+DRLY
Sbjct: 358 LSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLY 417
Query: 415 FVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSE 474
FVMEYVNGGDLMYHIQQVG+FKEP AVFYAAEI+IGLFFL +GIIYRDLKLDNVMLDSE
Sbjct: 418 FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE 477
Query: 475 GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAG 534
GHIKIADFGMCKE++ DGVTT+TFCGTPDYIAPEIIAYQPYGKSVDWWA+GVLLYEMLAG
Sbjct: 478 GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAG 537
Query: 535 QPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREH 594
Q PF+GEDEDELFQSIMEHNV+YPKS+SKEAV+ICKGLMTKHP KRLGCGPEGERD++EH
Sbjct: 538 QAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH 597
Query: 595 AFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDF 653
AFFR IDWEKLE +EIQPP+KPK K NFDK FTR LTP D+L I N+DQ++F
Sbjct: 598 AFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEF 657
Query: 654 EGFSYVNPQFV 664
GFSY NP+FV
Sbjct: 658 AGFSYTNPEFV 668
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 1041 bits (2691), Expect = 0.0
Identities = 487/673 (72%), Positives = 566/673 (84%), Gaps = 26/673 (3%)
Query: 20 FARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCH 79
F RKGALRQK VHEVK HKF ARFFKQPTFCSHCTDFIWG GKQG QCQVC FVVH+RCH
Sbjct: 19 FCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCH 78
Query: 80 EFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNV 139
EFVTF CPGA KGP TDDPR+KHKF++H+Y SPTFCDHCGSLLYGL+HQGMKC C+MNV
Sbjct: 79 EFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNV 138
Query: 140 HKQCVINVPSLCGMDHTEKRGRIYL--KAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVK 197
H++CV +VPSLCG+DHTE+RGR+ L +A ADE +HVTV +A+NLIPMDPNGLSDPYVK
Sbjct: 139 HRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADE-IHVTVGEARNLIPMDPNGLSDPYVK 197
Query: 198 LKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMG 257
LKLIPDP+N +KQKT+T+++TLNP WNE+F F LKP D +RRLSVE+WDWDRT+RNDFMG
Sbjct: 198 LKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMG 257
Query: 258 SLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFE----------K 307
++SFGVSEL+K P GWYKLLNQEEGEYYNVP+ + D N L QKFE +
Sbjct: 258 AMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADAD---NCSLLQKFEACNYPLELYER 314
Query: 308 AKLGPAGNKVISPSEDRKQPSN-----NLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTE 362
++GP+ + + SPS P + R+ ++DF+FLMVLGKGSFGKVMLA+R+G++
Sbjct: 315 VRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSD 374
Query: 363 ELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP-----FLTQLHSCFQTVDRLYFVM 417
ELYAIKILKKDV++QDDDV+CT+VEKRVLAL + P FLTQLHS FQT DRLYFVM
Sbjct: 375 ELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVM 434
Query: 418 EYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHI 477
EYV GGDLMYHIQQ+GKFKEP A FYAAEI+IGLFFLH +GIIYRDLKLDNVMLD+EGHI
Sbjct: 435 EYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHI 494
Query: 478 KIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPP 537
KI DFGMCKE++ G TTRTFCGTPDYIAPEIIAYQPYGKSVDWW++GVLLYEMLAGQPP
Sbjct: 495 KITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPP 554
Query: 538 FDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFF 597
FDGEDE+ELFQ+IME V+YPKSLS+EAV+ICKG +TKHP KRLG GP+GE +R H FF
Sbjct: 555 FDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFF 614
Query: 598 RRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFS 657
R IDWE+LE EI PPF+P+ CG+ ENFDKFFTR P LTPPD+LV+A+IDQ+DF+GF+
Sbjct: 615 RWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFT 674
Query: 658 YVNPQFVHPILQS 670
YVNP FVHP +S
Sbjct: 675 YVNPDFVHPDARS 687
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 590 bits (1522), Expect = e-168
Identities = 310/652 (47%), Positives = 409/652 (62%), Gaps = 92/652 (14%)
Query: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHE 80
R+GA+R++ VH+V HKF+A + +QPT+CSHC DFIWG GKQG+QCQVC VVHKRCHE
Sbjct: 156 RQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214
Query: 81 FVTFSCPGADKGPDTDDPRSK-------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCD 133
+ C G K D S+ HKF IH Y PTFCDHCGSLL+GL+ QG++C
Sbjct: 215 LIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCK 274
Query: 134 TCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSD 193
C MNVH++C NV CG+D G++
Sbjct: 275 VCKMNVHRRCETNVAPNCGVD---------------------------------ARGIAK 301
Query: 194 PYVKLKLIPDP-KNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTR 252
L + PD N +++ K I +PQ + PS++DR S D+ +
Sbjct: 302 VLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSS----PSEEDRSKSAPTSPCDQEIK 357
Query: 253 ---NDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAK 309
N+ +LSF + R + +A
Sbjct: 358 ELENNIRKALSF--------------------------------------DNRGEEHRAA 379
Query: 310 LGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKI 369
P G +++SP E+ + R+ L +FNF+ VLGKGSFGKVMLA+ KG +E+YA+K+
Sbjct: 380 SSPDG-QLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKV 438
Query: 370 LKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHI 429
LKKDV++QDDDV+CTM EKR+LAL K P+LTQL+ CFQT DRL+FVMEYVNGGDLM+ I
Sbjct: 439 LKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQI 498
Query: 430 QQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHM 489
Q+ KF EP++ FYAAE++ L FLH+ G+IYRDLKLDN++LD+EGH K+ADFGMCKE +
Sbjct: 499 QRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGI 558
Query: 490 MDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQS 549
++GVTT TFCGTPDYIAPEI+ YG SVDWWA GVL+YEM+AGQPPF+ ++ED+LF+S
Sbjct: 559 LNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFES 618
Query: 550 IMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGC--GPEGERDVREHAFFRRIDWEKLEN 607
I+ +V YP LSKEAVSI K MTK+P KRLGC GE +++H FF+ IDW LE
Sbjct: 619 ILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQ 678
Query: 608 REIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSY 658
++I+PPFKP++ K NFD+ FTR +PVLT D+ ++ I+Q +F+GFSY
Sbjct: 679 KKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSY 730
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 404 bits (1039), Expect = e-112
Identities = 196/336 (58%), Positives = 250/336 (74%), Gaps = 2/336 (0%)
Query: 329 NNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK 388
N+ +R+ + +F F+ VLGKGSFGKVMLA K T +LYA+K+LKKDV++QDDDVECTM EK
Sbjct: 345 NSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEK 404
Query: 389 RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEIS 448
R+L+L PFLTQL CFQT DRL+FVME+VNGGDLM+HIQ+ +F E +A FYAAEI
Sbjct: 405 RILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEII 464
Query: 449 IGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPE 508
L FLH +GIIYRDLKLDNV+LD EGH K+ADFGMCKE + +GVTT TFCGTPDYIAPE
Sbjct: 465 SALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE 524
Query: 509 IIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSI 568
I+ YG +VDWWA GVLLYEML G PF+ E+ED+LF++I+ V YP L ++A I
Sbjct: 525 ILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGI 584
Query: 569 CKGLMTKHPAKRLGCGPE-GERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENF 626
K MTK+P RLG + GE + H FF+ IDW +L +R+I+PPF+P++ + NF
Sbjct: 585 LKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNF 644
Query: 627 DKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQ 662
D F + +PVLTP D+ + I+Q +F FSYV+P+
Sbjct: 645 DPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE 680
Score = 157 bits (398), Expect = 2e-38
Identities = 71/145 (48%), Positives = 96/145 (66%), Gaps = 10/145 (6%)
Query: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHE 80
R+ A+R++ VH++ HKF+A + +QPT+CSHC +FIWG FGKQG+QCQVC VVHKRCH
Sbjct: 158 RQRAMRRR-VHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHH 216
Query: 81 FVTFSCPGADKGPDTDDPRSK--------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKC 132
+ +C + D ++ HKF IH Y PTFCDHCGSLL+G++ QG++C
Sbjct: 217 LIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQC 276
Query: 133 DTCDMNVHKQCVINVPSLCGMDHTE 157
C MNVH +C NV CG++ E
Sbjct: 277 KICKMNVHIRCQANVAPNCGVNAVE 301
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 387 bits (995), Expect = e-107
Identities = 194/343 (56%), Positives = 245/343 (71%), Gaps = 6/343 (1%)
Query: 320 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 379
P ++++PS + ++K+ DF +LGKGSFGKV LA+ K T + +AIK LKKDVV+ DD
Sbjct: 362 PELNKERPSLQI-KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
Query: 380 DVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQ 439
DVECTMVEKRVL+L + PFLT + FQT + L+FVMEY+NGGDLMYHIQ KF +
Sbjct: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
Query: 440 AVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFC 499
A FYAAEI +GL FLH +GI+YRDLKLDN++LD +GHIKIADFGMCKE+M+ T TFC
Sbjct: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540
Query: 500 GTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPK 559
GTPDYIAPEI+ Q Y SVDWW++GVLLYEML GQ PF G+DE+ELF SI N YP+
Sbjct: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600
Query: 560 SLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVC 619
L KEA + L + P KRLG D+R+H FR I+WE+LE +EI PPF+PKV
Sbjct: 601 WLEKEAKDLLVKLFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVK 656
Query: 620 GK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
NFDK F +P L+ D+ +I ++DQ+ F FS++NP
Sbjct: 657 SPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 699
Score = 154 bits (388), Expect = 3e-37
Identities = 68/140 (48%), Positives = 93/140 (66%), Gaps = 7/140 (5%)
Query: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
R+GA++Q VH VK H+F A FF QPTFCS C +F+WG KQG+QC+ C +HK+C +
Sbjct: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
Query: 82 VTFSCPG-ADKGPDTDDPRSK------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDT 134
V C G A +T + + H+FK++ Y SPTFC+HCG+LL+GL QG+KCD
Sbjct: 205 VIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDA 264
Query: 135 CDMNVHKQCVINVPSLCGMD 154
C MNVH +C V +LCG++
Sbjct: 265 CGMNVHHRCQTKVANLCGIN 284
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 375 bits (964), Expect = e-104
Identities = 198/364 (54%), Positives = 248/364 (68%), Gaps = 6/364 (1%)
Query: 303 QKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTE 362
Q FEK K G AG + S + + + +F F VLGKGSFGKV+L + KG
Sbjct: 314 QGFEK-KTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRG 372
Query: 363 ELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNG 422
E +AIK LKKDVV+ DDDVECTMVEKRVL L + PFLT L FQT D L+FVME++NG
Sbjct: 373 EYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNG 432
Query: 423 GDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADF 482
GDLMYHIQ G+F+ +A FYAAEI GL FLH +GIIYRDLKLDNV+LD +GHIKIADF
Sbjct: 433 GDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADF 492
Query: 483 GMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGED 542
GMCKE++ TFCGTPDYIAPEI+ Y SVDWW++GVLLYEML GQ PF G+D
Sbjct: 493 GMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDD 552
Query: 543 EDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDW 602
EDELF+SI YP+ ++KE+ I + L + P KRLG +++ H FF+ I+W
Sbjct: 553 EDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGV----TGNIKIHPFFKTINW 608
Query: 603 EKLENREIQPPFKPKV-CGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
LE R ++PPF+PKV + NFD+ F + L+ D+ +I ++DQS F GFS+VNP
Sbjct: 609 TLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
Query: 662 QFVH 665
+F H
Sbjct: 669 KFEH 672
Score = 159 bits (403), Expect = 6e-39
Identities = 69/140 (49%), Positives = 96/140 (68%), Gaps = 7/140 (5%)
Query: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
R+GA++Q +H +K+H+FIA FF QPTFCS C DF+WG KQG++C+ C +HK+C +
Sbjct: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203
Query: 82 VTFSCPG-ADKGPDTDDPRSK------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDT 134
+ C G A DT + + H+FK+H Y SPTFCDHCGSLL+GL+ QG+KC+
Sbjct: 204 IIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCED 263
Query: 135 CDMNVHKQCVINVPSLCGMD 154
C MNVH +C V +LCG++
Sbjct: 264 CGMNVHHKCREKVANLCGIN 283
Score = 51.6 bits (122), Expect = 2e-06
Identities = 22/64 (34%), Positives = 32/64 (50%)
Query: 102 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGR 161
H+F +G PTFC C ++GL QG KC C+ +HK+C+ + C R
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
Query: 162 IYLK 165
I+ K
Sbjct: 219 IFQK 222
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 375 bits (964), Expect = e-104
Identities = 198/364 (54%), Positives = 248/364 (68%), Gaps = 6/364 (1%)
Query: 303 QKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTE 362
Q FEK K G AG + S + + + +F F VLGKGSFGKV+L + KG
Sbjct: 314 QGFEK-KTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRG 372
Query: 363 ELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNG 422
E +AIK LKKDVV+ DDDVECTMVEKRVL L + PFLT L FQT D L+FVME++NG
Sbjct: 373 EYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNG 432
Query: 423 GDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADF 482
GDLMYHIQ G+F+ +A FYAAEI GL FLH +GIIYRDLKLDNV+LD +GHIKIADF
Sbjct: 433 GDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADF 492
Query: 483 GMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGED 542
GMCKE++ TFCGTPDYIAPEI+ Y SVDWW++GVLLYEML GQ PF G+D
Sbjct: 493 GMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDD 552
Query: 543 EDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDW 602
EDELF+SI YP+ ++KE+ I + L + P KRLG +++ H FF+ I+W
Sbjct: 553 EDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGV----TGNIKIHPFFKTINW 608
Query: 603 EKLENREIQPPFKPKV-CGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
LE R ++PPF+PKV + NFD+ F + L+ D+ +I ++DQS F GFS+VNP
Sbjct: 609 TLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
Query: 662 QFVH 665
+F H
Sbjct: 669 KFEH 672
Score = 159 bits (403), Expect = 6e-39
Identities = 69/140 (49%), Positives = 96/140 (68%), Gaps = 7/140 (5%)
Query: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
R+GA++Q +H +K+H+FIA FF QPTFCS C DF+WG KQG++C+ C +HK+C +
Sbjct: 144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDK 203
Query: 82 VTFSCPG-ADKGPDTDDPRSK------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDT 134
+ C G A DT + + H+FK+H Y SPTFCDHCGSLL+GL+ QG+KC+
Sbjct: 204 IIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCED 263
Query: 135 CDMNVHKQCVINVPSLCGMD 154
C MNVH +C V +LCG++
Sbjct: 264 CGMNVHHKCREKVANLCGIN 283
Score = 51.6 bits (122), Expect = 2e-06
Identities = 22/64 (34%), Positives = 32/64 (50%)
Query: 102 HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGR 161
H+F +G PTFC C ++GL QG KC C+ +HK+C+ + C R
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDT 218
Query: 162 IYLK 165
I+ K
Sbjct: 219 IFQK 222
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 373 bits (957), Expect = e-103
Identities = 182/367 (49%), Positives = 247/367 (67%), Gaps = 17/367 (4%)
Query: 312 PAGNKVISPSEDRKQPSNNLDRVK------LTDFNFLMVLGKGSFGKVMLADRKGTEELY 365
P+ ++ + + K+ N + K L DF+ L V+G+GS+ KV+L K T+ +Y
Sbjct: 221 PSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIY 280
Query: 366 AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDL 425
A+K++KK++V D+D++ EK V PFL LHSCFQT RL+FV+EYVNGGDL
Sbjct: 281 AMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDL 340
Query: 426 MYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC 485
M+H+Q+ K E A FY+AEIS+ L +LH+RGIIYRDLKLDNV+LDSEGHIK+ D+GMC
Sbjct: 341 MFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMC 400
Query: 486 KEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF------- 538
KE + G TT TFCGTP+YIAPEI+ + YG SVDWWA GVL++EM+AG+ PF
Sbjct: 401 KEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSD 460
Query: 539 --DGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHA 595
D ED LFQ I+E + P+SLS +A S+ K + K P +RLGC P+ G D++ H
Sbjct: 461 NPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 520
Query: 596 FFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFE 654
FFR +DW+ +E +++ PPFKP + G+ G +NFD FT LTP D ++ IDQS+FE
Sbjct: 521 FFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFE 580
Query: 655 GFSYVNP 661
GF Y+NP
Sbjct: 581 GFEYINP 587
Score = 69.3 bits (168), Expect = 1e-11
Identities = 28/65 (43%), Positives = 41/65 (63%)
Query: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
R+GA R + ++ H F A+ F + C+ CTD IWG G+QG++C C +VHK+CH+
Sbjct: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185
Query: 82 VTFSC 86
VT C
Sbjct: 186 VTIEC 190
Score = 40.8 bits (94), Expect = 0.004
Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 8/75 (10%)
Query: 86 CPGADKGPDTDDPR--------SKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM 137
CPG DK R + H F+ + C C ++GL QG KC C +
Sbjct: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
Query: 138 NVHKQCVINVPSLCG 152
VHK+C V CG
Sbjct: 177 LVHKKCHKLVTIECG 191
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 364 bits (935), Expect = e-100
Identities = 181/356 (50%), Positives = 242/356 (67%), Gaps = 15/356 (4%)
Query: 321 SEDRKQPSNNLDRVKLT------DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV 374
SED K + +D +K++ DF+ + V+G+GS+ KV+L K +++YA+K++KK++
Sbjct: 45 SEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKEL 104
Query: 375 VIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK 434
V D+D++ EK V PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ K
Sbjct: 105 VHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRK 164
Query: 435 FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT 494
E A FYAAEI I L FLH+RGIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G T
Sbjct: 165 LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDT 224
Query: 495 TRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF-------DGEDEDELF 547
T TFCGTP+YIAPEI+ + YG SVDWWA GVL++EM+AG+ PF D ED LF
Sbjct: 225 TSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLF 284
Query: 548 QSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHAFFRRIDWEKLE 606
Q I+E + P+ LS +A + KG + K P +RLGC P+ G D++ HAFFR IDW+ LE
Sbjct: 285 QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLE 344
Query: 607 NREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
++ PPF+P++ G +NFD FT LTP D+ I IDQS+FEGF Y+NP
Sbjct: 345 KKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 364 bits (935), Expect = e-100
Identities = 181/356 (50%), Positives = 242/356 (67%), Gaps = 15/356 (4%)
Query: 321 SEDRKQPSNNLDRVKLT------DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV 374
SED K + +D +K++ DF+ + V+G+GS+ KV+L K +++YA+K++KK++
Sbjct: 45 SEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKEL 104
Query: 375 VIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK 434
V D+D++ EK V PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ K
Sbjct: 105 VHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRK 164
Query: 435 FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT 494
E A FYAAEI I L FLH+RGIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G T
Sbjct: 165 LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDT 224
Query: 495 TRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF-------DGEDEDELF 547
T TFCGTP+YIAPEI+ + YG SVDWWA GVL++EM+AG+ PF D ED LF
Sbjct: 225 TSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLF 284
Query: 548 QSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHAFFRRIDWEKLE 606
Q I+E + P+ LS +A + KG + K P +RLGC P+ G D++ HAFFR IDW+ LE
Sbjct: 285 QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLE 344
Query: 607 NREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
++ PPF+P++ G +NFD FT LTP D+ I IDQS+FEGF Y+NP
Sbjct: 345 KKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 364 bits (935), Expect = e-100
Identities = 181/356 (50%), Positives = 242/356 (67%), Gaps = 15/356 (4%)
Query: 321 SEDRKQPSNNLDRVKLT------DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV 374
SED K + +D +K++ DF+ + V+G+GS+ KV+L K +++YA+K++KK++
Sbjct: 228 SEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKEL 287
Query: 375 VIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK 434
V D+D++ EK V PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ K
Sbjct: 288 VHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRK 347
Query: 435 FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT 494
E A FYAAEI I L FLH+RGIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G T
Sbjct: 348 LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDT 407
Query: 495 TRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF-------DGEDEDELF 547
T TFCGTP+YIAPEI+ + YG SVDWWA GVL++EM+AG+ PF D ED LF
Sbjct: 408 TSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLF 467
Query: 548 QSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHAFFRRIDWEKLE 606
Q I+E + P+ LS +A + KG + K P +RLGC P+ G D++ HAFFR IDW+ LE
Sbjct: 468 QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLE 527
Query: 607 NREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
++ PPF+P++ G +NFD FT LTP D+ I IDQS+FEGF Y+NP
Sbjct: 528 KKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583
Score = 66.6 bits (161), Expect = 7e-11
Identities = 31/90 (34%), Positives = 45/90 (50%), Gaps = 13/90 (14%)
Query: 22 RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81
R+GA R + ++ H F A+ F + +C C++ IWG +QG++C C +VHKRCH
Sbjct: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGL 175
Query: 82 VTFSC-------------PGADKGPDTDDP 98
V +C P DK D D P
Sbjct: 176 VPLTCRKHMDSVMPSQEPPVDDKNEDADLP 205
Score = 45.4 bits (106), Expect = 2e-04
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 8/74 (10%)
Query: 86 CPGADKGPDTDDPR--------SKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM 137
CPG DK R + H F+ + +C C ++GL QG +C C +
Sbjct: 107 CPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKL 166
Query: 138 NVHKQCVINVPSLC 151
VHK+C VP C
Sbjct: 167 LVHKRCHGLVPLTC 180
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 331 bits (849), Expect = 1e-90
Identities = 165/346 (47%), Positives = 231/346 (66%), Gaps = 7/346 (2%)
Query: 318 ISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQ 377
I EDR+ S + L DF VLG+G FGKV+LA+ K T E++AIK LKK ++
Sbjct: 638 IQELEDRR--SQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVA 695
Query: 378 DDDVECTMVEKRVLALLD--KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKF 435
D+V+ M EKR+ ++ + PFL L +CFQT + + FVMEY GGDLM HI F
Sbjct: 696 RDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVF 754
Query: 436 KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTT 495
EP+AVFYAA + +GL +LH+ I+YRDLKLDN++LD+EG +KIADFG+CKE M G T
Sbjct: 755 SEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRT 814
Query: 496 RTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNV 555
TFCGTP+++APE++ Y ++VDWW GVL+YEML G+ PF G+DE+E+F SI+ V
Sbjct: 815 STFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEV 874
Query: 556 SYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFK 615
YP+ LS EA+SI + L+ ++P +RLG + DV++H FFR IDW L +++++PPF
Sbjct: 875 RYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFI 934
Query: 616 PKVCGK-GAENFDKFFTRGQPVLTPP-DQLVIANIDQSDFEGFSYV 659
P + G+ NFD FT P+LTPP + +++ +Q F F Y+
Sbjct: 935 PTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 322 bits (824), Expect = 9e-88
Identities = 166/350 (47%), Positives = 227/350 (64%), Gaps = 11/350 (3%)
Query: 320 PSEDRKQPSNNL------DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKD 373
PSE ++ P L + L DF FL VLG+G FGKV+L++ + + EL+AIK LKK
Sbjct: 596 PSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKG 655
Query: 374 VVIQDDDVECTMVEKRVLALLDKP--PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
++ D+VE M EKR+LA + PFL L CFQT + + FVMEY GGDLM HI
Sbjct: 656 DIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS 715
Query: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
F EP+A+FY+A + +GL FLH+ I+YRDLKLDN++LD+EG++KIADFG+CKE M
Sbjct: 716 -DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGY 774
Query: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
G T TFCGTP+++APE++ Y ++VDWW GVLLYEML G+ PF G+DE+E+F SI+
Sbjct: 775 GDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV 834
Query: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
V YP+ LS EA+ I + L+ ++P +RLG DV++ FFR + WE L R +
Sbjct: 835 NDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLP 894
Query: 612 PPFKPKVCGK-GAENFDKFFTRGQPVLTPP-DQLVIANIDQSDFEGFSYV 659
PPF P + G+ NFD+ FT P L+PP D + +Q+ F F +V
Sbjct: 895 PPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 322 bits (824), Expect = 9e-88
Identities = 166/350 (47%), Positives = 227/350 (64%), Gaps = 11/350 (3%)
Query: 320 PSEDRKQPSNNL------DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKD 373
PSE ++ P L + L DF FL VLG+G FGKV+L++ + + EL+AIK LKK
Sbjct: 590 PSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKG 649
Query: 374 VVIQDDDVECTMVEKRVLALLDKP--PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
++ D+VE M EKR+LA + PFL L CFQT + + FVMEY GGDLM HI
Sbjct: 650 DIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS 709
Query: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
F EP+A+FY+A + +GL FLH+ I+YRDLKLDN++LD+EG++KIADFG+CKE M
Sbjct: 710 -DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGY 768
Query: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
G T TFCGTP+++APE++ Y ++VDWW GVLLYEML G+ PF G+DE+E+F SI+
Sbjct: 769 GDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV 828
Query: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
V YP+ LS EA+ I + L+ ++P +RLG DV++ FFR + WE L R +
Sbjct: 829 NDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLP 888
Query: 612 PPFKPKVCGK-GAENFDKFFTRGQPVLTPP-DQLVIANIDQSDFEGFSYV 659
PPF P + G+ NFD+ FT P L+PP D + +Q+ F F +V
Sbjct: 889 PPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 938
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 320 bits (820), Expect = 3e-87
Identities = 157/331 (47%), Positives = 222/331 (67%), Gaps = 6/331 (1%)
Query: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
+V + DF++L +LGKG+FGKV+L K T YA+KIL+K+V+I D+V T+ E RVL
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
Query: 393 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 452
+ PFLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L
Sbjct: 206 NT-RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 264
Query: 453 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAY 512
+LH R ++YRD+KL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++
Sbjct: 265 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 324
Query: 513 QPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGL 572
YG++VDWW GV++YEM+ G+ PF +D + LF+ I+ + +P++LS EA S+ GL
Sbjct: 325 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 384
Query: 573 MTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFT 631
+ K P +RLG GP ++V EH FF I+W+ + +++ PPFKP+V + FD FT
Sbjct: 385 LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 444
Query: 632 RGQPVLTPPDQ---LVIANIDQ-SDFEGFSY 658
+TPPD+ L + +DQ + F FSY
Sbjct: 445 AQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 317 bits (813), Expect = 2e-86
Identities = 162/388 (41%), Positives = 240/388 (61%), Gaps = 16/388 (4%)
Query: 286 YNVPIPEGDEEGNMEL--------RQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337
++V PE EE + RQ+ E+ P E+ + + R +
Sbjct: 87 FHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMN 146
Query: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397
DF++L +LGKG+FGKV+L K + + YA+KILKK+V+I D+V T+ E RVL +
Sbjct: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT-RH 205
Query: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
PFLT L FQT DRL FVMEYVNGG+L +H+ + F E + FY AEI L +LH
Sbjct: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517
I+YRDLKL+N+MLD +GHIKI DFG+CKE + D T +TFCGTP+Y+APE++ YG+
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
Query: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577
+VDWW GV++YEM+ G+ PF +D ++LF+ I+ ++ +P++LS +A S+ GL+ K P
Sbjct: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
Query: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPV 636
KRLG GP+ +++ H+FF ++W+ + ++++ PPFKP+V + FD+ FT
Sbjct: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
Query: 637 LTPPDQLVIANIDQSD------FEGFSY 658
+TPP++ +D D F FSY
Sbjct: 446 ITPPEKYDEDGMDCMDNERRPHFPQFSY 473
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 316 bits (810), Expect = 4e-86
Identities = 156/366 (42%), Positives = 233/366 (63%), Gaps = 10/366 (2%)
Query: 286 YNVPIPEGDEEGNMEL--------RQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337
++V PE EE + RQ+ E+ P E+ + + R +
Sbjct: 87 FHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMN 146
Query: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397
DF++L +LGKG+FGKV+L K + + YA+KILKK+V+I D+V T+ E RVL +
Sbjct: 147 DFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT-RH 205
Query: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
PFLT L FQT DRL FVMEYVNGG+L +H+ + F E + FY AEI L +LH
Sbjct: 206 PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSG 265
Query: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517
I+YRDLKL+N+MLD +GHIKI DFG+CKE + D T +TFCGTP+Y+APE++ YG+
Sbjct: 266 KIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGR 325
Query: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577
+VDWW GV++YEM+ G+ PF +D ++LF+ I+ ++ +P++LS +A S+ GL+ K P
Sbjct: 326 AVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDP 385
Query: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFTRGQPV 636
KRLG GP+ +++ H+FF ++W+ + ++++ PPFKP+V + FD+ FT
Sbjct: 386 NKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTIT 445
Query: 637 LTPPDQ 642
+TPP++
Sbjct: 446 ITPPEK 451
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 311 bits (798), Expect = 1e-84
Identities = 148/312 (47%), Positives = 212/312 (67%), Gaps = 3/312 (0%)
Query: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
RV + +F +L +LGKG+FGKV+L K T YA+KILKK+V++ D+V T+ E RVL
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 393 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 452
+ PFLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L
Sbjct: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262
Query: 453 FLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 511
+LH ++ ++YRDLKL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 512 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 571
YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P++L EA S+ G
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382
Query: 572 LMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFF 630
L+ K P +RLG G E +++ +H FF I W+ + +++ PPFKP+V + FD+ F
Sbjct: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442
Query: 631 TRGQPVLTPPDQ 642
T +TPPDQ
Sbjct: 443 TAQMITITPPDQ 454
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 311 bits (798), Expect = 1e-84
Identities = 148/312 (47%), Positives = 212/312 (67%), Gaps = 3/312 (0%)
Query: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
RV + +F +L +LGKG+FGKV+L K T YA+KILKK+V++ D+V T+ E RVL
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 393 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 452
+ PFLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L
Sbjct: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262
Query: 453 FLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 511
+LH ++ ++YRDLKL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 512 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 571
YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P++L EA S+ G
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382
Query: 572 LMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFF 630
L+ K P +RLG G E +++ +H FF I W+ + +++ PPFKP+V + FD+ F
Sbjct: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442
Query: 631 TRGQPVLTPPDQ 642
T +TPPDQ
Sbjct: 443 TAQMITITPPDQ 454
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 311 bits (798), Expect = 1e-84
Identities = 148/312 (47%), Positives = 212/312 (67%), Gaps = 3/312 (0%)
Query: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
RV + +F +L +LGKG+FGKV+L K T YA+KILKK+V++ D+V T+ E RVL
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 393 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 452
+ PFLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L
Sbjct: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262
Query: 453 FLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 511
+LH ++ ++YRDLKL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 512 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 571
YG++VDWW GV++YEM+ G+ PF +D ++LF+ I+ + +P++L EA S+ G
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382
Query: 572 LMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFF 630
L+ K P +RLG G E +++ +H FF I W+ + +++ PPFKP+V + FD+ F
Sbjct: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442
Query: 631 TRGQPVLTPPDQ 642
T +TPPDQ
Sbjct: 443 TAQMITITPPDQ 454
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 299 bits (766), Expect = 5e-81
Identities = 164/418 (39%), Positives = 241/418 (57%), Gaps = 29/418 (6%)
Query: 255 FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELR---QKFEKAKLG 311
FM G+++ ++ A+ Y + E + P+ E N ++ LG
Sbjct: 27 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLG 86
Query: 312 PAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILK 371
P+ N PS DF+FL V+GKGSFGKV+LA K E YA+K+L+
Sbjct: 87 PSSNPHAKPS----------------DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQ 130
Query: 372 KDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
K +++ + + M E+ VL K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+
Sbjct: 131 KKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR 190
Query: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
F EP+A FYAAEI+ L +LH I+YRDLK +N++LDS+GHI + DFG+CKE++
Sbjct: 191 ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEH 250
Query: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
TT TFCGTP+Y+APE++ QPY ++VDWW G +LYEML G PPF + E++ +I+
Sbjct: 251 NSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL 310
Query: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
+ +++ A + +GL+ K KRLG + +++ H FF I+W+ L N++I
Sbjct: 311 NKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKIT 369
Query: 612 PPFKPKVCG-KGAENFDKFFTRGQPV-----LTPPDQLVIANIDQS--DFEGFSYVNP 661
PPF P V G +FD FT +PV +P LV A++ ++ F GFSY P
Sbjct: 370 PPFNPNVSGPNDLRHFDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 299 bits (766), Expect = 5e-81
Identities = 164/418 (39%), Positives = 241/418 (57%), Gaps = 29/418 (6%)
Query: 255 FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELR---QKFEKAKLG 311
FM G+++ ++ A+ Y + E + P+ E N ++ LG
Sbjct: 41 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLG 100
Query: 312 PAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILK 371
P+ N PS DF+FL V+GKGSFGKV+LA K E YA+K+L+
Sbjct: 101 PSSNPHAKPS----------------DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQ 144
Query: 372 KDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
K +++ + + M E+ VL K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+
Sbjct: 145 KKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR 204
Query: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
F EP+A FYAAEI+ L +LH I+YRDLK +N++LDS+GHI + DFG+CKE++
Sbjct: 205 ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEH 264
Query: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
TT TFCGTP+Y+APE++ QPY ++VDWW G +LYEML G PPF + E++ +I+
Sbjct: 265 NSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL 324
Query: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
+ +++ A + +GL+ K KRLG + +++ H FF I+W+ L N++I
Sbjct: 325 NKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKIT 383
Query: 612 PPFKPKVCG-KGAENFDKFFTRGQPV-----LTPPDQLVIANIDQS--DFEGFSYVNP 661
PPF P V G +FD FT +PV +P LV A++ ++ F GFSY P
Sbjct: 384 PPFNPNVSGPNDLRHFDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 440
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 299 bits (766), Expect = 5e-81
Identities = 164/418 (39%), Positives = 241/418 (57%), Gaps = 29/418 (6%)
Query: 255 FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELR---QKFEKAKLG 311
FM G+++ ++ A+ Y + E + P+ E N ++ LG
Sbjct: 55 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLG 114
Query: 312 PAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILK 371
P+ N PS DF+FL V+GKGSFGKV+LA K E YA+K+L+
Sbjct: 115 PSSNPHAKPS----------------DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQ 158
Query: 372 KDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
K +++ + + M E+ VL K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+
Sbjct: 159 KKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR 218
Query: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
F EP+A FYAAEI+ L +LH I+YRDLK +N++LDS+GHI + DFG+CKE++
Sbjct: 219 ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEH 278
Query: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
TT TFCGTP+Y+APE++ QPY ++VDWW G +LYEML G PPF + E++ +I+
Sbjct: 279 NSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL 338
Query: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
+ +++ A + +GL+ K KRLG + +++ H FF I+W+ L N++I
Sbjct: 339 NKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKIT 397
Query: 612 PPFKPKVCG-KGAENFDKFFTRGQPV-----LTPPDQLVIANIDQS--DFEGFSYVNP 661
PPF P V G +FD FT +PV +P LV A++ ++ F GFSY P
Sbjct: 398 PPFNPNVSGPNDLRHFDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 299 bits (766), Expect = 5e-81
Identities = 164/418 (39%), Positives = 241/418 (57%), Gaps = 29/418 (6%)
Query: 255 FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELR---QKFEKAKLG 311
FM G+++ ++ A+ Y + E + P+ E N ++ LG
Sbjct: 122 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLG 181
Query: 312 PAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILK 371
P+ N PS DF+FL V+GKGSFGKV+LA K E YA+K+L+
Sbjct: 182 PSSNPHAKPS----------------DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQ 225
Query: 372 KDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
K +++ + + M E+ VL K PFL LH FQT D+LYFV++Y+NGG+L YH+Q+
Sbjct: 226 KKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR 285
Query: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
F EP+A FYAAEI+ L +LH I+YRDLK +N++LDS+GHI + DFG+CKE++
Sbjct: 286 ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEH 345
Query: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
TT TFCGTP+Y+APE++ QPY ++VDWW G +LYEML G PPF + E++ +I+
Sbjct: 346 NSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL 405
Query: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
+ +++ A + +GL+ K KRLG + +++ H FF I+W+ L N++I
Sbjct: 406 NKPLQLKPNITNSARHLLEGLLQKDRTKRLG-AKDDFMEIKSHVFFSLINWDDLINKKIT 464
Query: 612 PPFKPKVCG-KGAENFDKFFTRGQPV-----LTPPDQLVIANIDQS--DFEGFSYVNP 661
PPF P V G +FD FT +PV +P LV A++ ++ F GFSY P
Sbjct: 465 PPFNPNVSGPNDLRHFDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
>gi|40254851 protein kinase PKNbeta [Homo sapiens]
Length = 889
Score = 298 bits (763), Expect = 1e-80
Identities = 164/378 (43%), Positives = 226/378 (59%), Gaps = 14/378 (3%)
Query: 295 EEGNMELRQKFEKAKLGPAGNKVISP--SEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGK 352
+E E + ++ + P + SP S RK P +L DF L VLG+G FGK
Sbjct: 520 QEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPP-------RLQDFRCLAVLGRGHFGK 572
Query: 353 VMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP--PFLTQLHSCFQTV 410
V+L KGT + YAIK LKK V+ D++E EKR+L + PFL L +CFQT
Sbjct: 573 VLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTS 632
Query: 411 DRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVM 470
FV E+V GGDLM I + F EPQA FY A + +GL FLH++ IIYRDLKLDN++
Sbjct: 633 SHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLL 691
Query: 471 LDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYE 530
LD++G +KIADFG+CKE + G T TFCGTP+++APE++ + Y ++VDWW GVLLYE
Sbjct: 692 LDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYE 751
Query: 531 MLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERD 590
ML G+ PF G+ E+E+F I+ + YP LS + + + L+ K P KRLG G + +
Sbjct: 752 MLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEE 811
Query: 591 VREHAFFRRIDWEKLENREIQPPFKPKVCGKG-AENFDKFFTRGQPVLTPP-DQLVIANI 648
++ FFR +W+ L R IQPPF P +CG F+ FT P LTPP ++
Sbjct: 812 IKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTAR 871
Query: 649 DQSDFEGFSYVNPQFVHP 666
Q+ F F +V+ +F+ P
Sbjct: 872 QQAAFRDFDFVSERFLEP 889
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 291 bits (745), Expect = 1e-78
Identities = 159/391 (40%), Positives = 226/391 (57%), Gaps = 24/391 (6%)
Query: 278 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337
L + ++ + P + DE + +L + LGP+GN P T
Sbjct: 117 LQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKP----------------T 160
Query: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397
DF+FL V+GKGSFGKV+LA RK + YA+K+L+K +V+ + + M E+ VL K
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E +A FYAAEI+ L +LH
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517
I+YRDLK +N++LDS GH+ + DFG+CKE + TT TFCGTP+Y+APE+I QPY
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577
+VDWW G +LYEML G PPF D E++ +I+ +S +S A SI + L+ K
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
Query: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCG-KGAENFDKFFTRG--- 633
RLG E +++ H FF + W L ++I PPF P V G NFD FT
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 459
Query: 634 -QPVLTPPDQLVIANIDQSD--FEGFSYVNP 661
++ +V A++ ++D F GFSY P
Sbjct: 460 YSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 291 bits (745), Expect = 1e-78
Identities = 159/391 (40%), Positives = 226/391 (57%), Gaps = 24/391 (6%)
Query: 278 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337
L + ++ + P + DE + +L + LGP+GN P T
Sbjct: 117 LQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKP----------------T 160
Query: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397
DF+FL V+GKGSFGKV+LA RK + YA+K+L+K +V+ + + M E+ VL K
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E +A FYAAEI+ L +LH
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517
I+YRDLK +N++LDS GH+ + DFG+CKE + TT TFCGTP+Y+APE+I QPY
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577
+VDWW G +LYEML G PPF D E++ +I+ +S +S A SI + L+ K
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
Query: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCG-KGAENFDKFFTRG--- 633
RLG E +++ H FF + W L ++I PPF P V G NFD FT
Sbjct: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 459
Query: 634 -QPVLTPPDQLVIANIDQSD--FEGFSYVNP 661
++ +V A++ ++D F GFSY P
Sbjct: 460 YSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 279 bits (714), Expect = 5e-75
Identities = 144/368 (39%), Positives = 221/368 (60%), Gaps = 12/368 (3%)
Query: 300 ELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLD-----RVKLTDFNFLMVLGKGSFGKVM 354
EL + PAG SP R + NL + TDF+FL V+GKG++GKV+
Sbjct: 53 ELPDHCYRMNSSPAGTP--SPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVL 110
Query: 355 LADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLY 414
LA RK YA+K+L+K +++ + M E+ VL + PFL L FQT ++LY
Sbjct: 111 LAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLY 170
Query: 415 FVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSE 474
FV++YVNGG+L +H+Q+ +F EP+A FYAAE++ + +LH IIYRDLK +N++LD +
Sbjct: 171 FVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQ 230
Query: 475 GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAG 534
GH+ + DFG+CKE + TT TFCGTP+Y+APE++ +PY ++VDWW G +LYEML G
Sbjct: 231 GHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHG 290
Query: 535 QPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREH 594
PPF +D +++++I+ + P + A + + L+ K +RLG + +++ H
Sbjct: 291 LPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNH 349
Query: 595 AFFRRIDWEKLENREIQPPFKPKVCGKG-AENFDKFFTR---GQPVLTPPDQLVIANIDQ 650
FF I+W+ L ++ + PPF P V G ++FD FT+ + + PD + ++
Sbjct: 350 VFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGAS 409
Query: 651 SDFEGFSY 658
S F GFSY
Sbjct: 410 SAFLGFSY 417
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,515,040
Number of Sequences: 37866
Number of extensions: 1433873
Number of successful extensions: 7555
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 852
Number of HSP's successfully gapped in prelim test: 303
Number of HSP's that attempted gapping in prelim test: 4136
Number of HSP's gapped (non-prelim): 2106
length of query: 672
length of database: 18,247,518
effective HSP length: 109
effective length of query: 563
effective length of database: 14,120,124
effective search space: 7949629812
effective search space used: 7949629812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.