Search of human proteins with 4506039

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506039 protein regulator of cytokinesis 1 isoform 1 [Homo
sapiens]
         (620 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506039 protein regulator of cytokinesis 1 isoform 1 [Homo sa...  1223   0.0  
gi|40807443 protein regulator of cytokinesis 1 isoform 2 [Homo s...  1187   0.0  
gi|40807445 protein regulator of cytokinesis 1 isoform 3 [Homo s...  1104   0.0  
gi|71061468 centromere protein E [Homo sapiens]                        71   3e-12
gi|45439327 periplakin [Homo sapiens]                                  65   1e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    64   5e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    61   3e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    60   6e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        59   1e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        59   1e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         59   1e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         59   1e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         59   1e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         59   1e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         59   1e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         59   1e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    57   5e-08
gi|148746195 trichohyalin [Homo sapiens]                               57   5e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     57   5e-08
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    57   7e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    56   1e-07
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                55   1e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     55   2e-07
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    53   7e-07
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  53   7e-07
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    53   1e-06
gi|81295809 pericentrin [Homo sapiens]                                 53   1e-06
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    52   1e-06
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]        52   1e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             52   2e-06

>gi|4506039 protein regulator of cytokinesis 1 isoform 1 [Homo
           sapiens]
          Length = 620

 Score = 1223 bits (3165), Expect = 0.0
 Identities = 620/620 (100%), Positives = 620/620 (100%)

Query: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
           MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES
Sbjct: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60

Query: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
           LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE
Sbjct: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120

Query: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
           LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ
Sbjct: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180

Query: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
           IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR
Sbjct: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240

Query: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
           TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE
Sbjct: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300

Query: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
           LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE
Sbjct: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360

Query: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
           TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA
Sbjct: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420

Query: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
           FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN
Sbjct: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480

Query: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
           TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG
Sbjct: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540

Query: 541 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL 600
           RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL
Sbjct: 541 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL 600

Query: 601 SKASKSDATSGILNSTNIQS 620
           SKASKSDATSGILNSTNIQS
Sbjct: 601 SKASKSDATSGILNSTNIQS 620


>gi|40807443 protein regulator of cytokinesis 1 isoform 2 [Homo
           sapiens]
          Length = 606

 Score = 1187 bits (3072), Expect = 0.0
 Identities = 606/620 (97%), Positives = 606/620 (97%), Gaps = 14/620 (2%)

Query: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
           MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES
Sbjct: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60

Query: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
           LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE
Sbjct: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120

Query: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
           LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ
Sbjct: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180

Query: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
           IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR
Sbjct: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240

Query: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
           TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE
Sbjct: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300

Query: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
           LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE
Sbjct: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360

Query: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
           TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA
Sbjct: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420

Query: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
           FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN
Sbjct: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480

Query: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
           TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG
Sbjct: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540

Query: 541 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFAKDPSLSDSSTVGLQREL 600
           RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFA              REL
Sbjct: 541 RHGANKENLELNGSILSGGYPGSAPLQRNFSINSVASTYSEFA--------------REL 586

Query: 601 SKASKSDATSGILNSTNIQS 620
           SKASKSDATSGILNSTNIQS
Sbjct: 587 SKASKSDATSGILNSTNIQS 606


>gi|40807445 protein regulator of cytokinesis 1 isoform 3 [Homo
           sapiens]
          Length = 566

 Score = 1104 bits (2856), Expect = 0.0
 Identities = 557/557 (100%), Positives = 557/557 (100%)

Query: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
           MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES
Sbjct: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60

Query: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
           LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE
Sbjct: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120

Query: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
           LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ
Sbjct: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180

Query: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
           IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR
Sbjct: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240

Query: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
           TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE
Sbjct: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300

Query: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
           LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE
Sbjct: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360

Query: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
           TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA
Sbjct: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420

Query: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
           FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN
Sbjct: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480

Query: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
           TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG
Sbjct: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540

Query: 541 RHGANKENLELNGSILS 557
           RHGANKENLELNGSILS
Sbjct: 541 RHGANKENLELNGSILS 557


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 107/469 (22%), Positives = 206/469 (43%), Gaps = 65/469 (13%)

Query: 8    AEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIK 67
            ++E I  L K  ++L+ I E + +  DQ       +K+HI+E L   I E +S +E+   
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQ-------LKEHIRETL-AKIQESQSKQEQ--- 1388

Query: 68   SISVCQKELNTLCSELHVEPFQEEG------ETTILQLEKDLRTQVELMRKQKKERKQEL 121
            S+++ +K+  T      +E F+ +       E  +L L K L+   + M+   KE K +L
Sbjct: 1389 SLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE-KDDL 1447

Query: 122  KLLQEQDQELCEILCMPHYDIDSASVPSLEELN-------QFRQHVTTLRETKASRREEF 174
            + LQE  Q   + L     +I +  + + EEL        +  + +  LR   + +  E 
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507

Query: 175  VSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEA 234
             +I++Q+    ++L +     +E+      E+ F  +++ I+ +Q+ + +L+  K   +A
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEK------EEQF--NIKQISEVQEKVNELKQFKEHRKA 1559

Query: 235  ---VCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMK 291
                 + + +++ EL +RLQ  +EE + +       K +V++ALQ+E D+L+E    N K
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK-RVQEALQIERDQLKE----NTK 1614

Query: 292  KVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKEL 351
            +++  ++            SQE+   F    A + T+  +     EI  LK  +E  K  
Sbjct: 1615 EIVAKMK-----------ESQEKEYQFLKMTAVNETQEKM----CEIEHLKEQFETQKLN 1659

Query: 352  FEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLK-EEKQRAKLQKMLPKLEEELKARI 410
             E ++   E  RL         +    T    +L   EE  + +  ++   L E +   +
Sbjct: 1660 LENIE--TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL 1717

Query: 411  ELWEQ-----EHSKAFMVNGQKFMEYVAEQW-EMHRLEKERAKQERQLK 453
            E  E+      H K       K    V+E+  E+  ++K+       LK
Sbjct: 1718 EKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALK 1766



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 105/506 (20%), Positives = 211/506 (41%), Gaps = 93/506 (18%)

Query: 9    EESIVCLQKALNH-------LRE----IWELIGIPEDQRLQRTEVVKK----HI----KE 49
            E  I  LQK LN        LRE    + EL  +P +    R E+  K    HI    K+
Sbjct: 719  EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKD 778

Query: 50   LLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVEL 109
             L   +  +ES  + L++ I   + +L T  S       + +   T   L  D   + ++
Sbjct: 779  KLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT---LHMDFEQKYKM 835

Query: 110  MRKQKKERKQELKLLQEQDQE-------LCEILCMPHYDIDSASVPSLEELNQFRQHVTT 162
            + ++ +   QE+  L ++ Q+       L   L     ++   +    E LN+  Q    
Sbjct: 836  VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQ---- 891

Query: 163  LRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLL 222
            L+E   +R     +++R+  L  E+L  T +   E   + +++D           L++L 
Sbjct: 892  LKEQLENRDSTLQTVEREKTLITEKLQQTLE---EVKTLTQEKD----------DLKQLQ 938

Query: 223  RQLEMQKSQ-----NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQL 277
              L++++ Q     ++ V   + TQ  +L + L+  ++ +E + T+ S    +V + L +
Sbjct: 939  ESLQIERDQLKSDIHDTVNMNIDTQ-EQLRNALESLKQHQETINTLKSKISEEVSRNLHM 997

Query: 278  E----------------VDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPF 321
            E                +D+ ++L+ +N + +   ++   +         ++QR+ F+  
Sbjct: 998  EENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI--------IEQQRKIFSLI 1049

Query: 322  CAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNR 381
              ++  + +L+   AE  +LK   + + E+   ++  EE   L  E +++     +  N 
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMT--IENQEELRLLGDELKKQQEIVAQEKNH 1107

Query: 382  GGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL 441
                +K+E + ++    L ++EE+LK        E S+      Q+ +    E  EM + 
Sbjct: 1108 A---IKKEGELSRTCDRLAEVEEKLK--------EKSQQLQEKQQQLLNVQEEMSEMQKK 1156

Query: 442  EKERAKQERQLKNKKQT----ETEML 463
              E    + +LKNK+ T    ETE L
Sbjct: 1157 INEIENLKNELKNKELTLEHMETERL 1182



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 97/460 (21%), Positives = 195/460 (42%), Gaps = 74/460 (16%)

Query: 47   IKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQ 106
            +  L+D  + ++      L   I+  QKELN    E   E  +EE    +L   K L ++
Sbjct: 700  LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN--EALREE--VILLSELKSLPSE 755

Query: 107  VELMRKQKKERKQELKLL-QEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRE 165
            VE +RK+ +++ +EL ++  E+D+   E++       +S     LEE+ + +  + T + 
Sbjct: 756  VERLRKEIQDKSEELHIITSEKDKLFSEVV-----HKESRVQGLLEEIGKTKDDLATTQS 810

Query: 166  TKASRREEFVSIKRQIILCMEELDHTPDTSFER--DVVCEDEDAFCLSLENIA-TLQKLL 222
               S  +EF + K            T    FE+   +V E+ +     + N++   QK  
Sbjct: 811  NYKSTDQEFQNFK------------TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD 858

Query: 223  RQLEMQKSQNEAVCEGLRTQIRELWDRLQIPE------EEREAVATIMSGSKAKVRKALQ 276
              L   K++     + L+ + RE+ +RL   E      E R++    +   K  + + LQ
Sbjct: 859  SSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQ 918

Query: 277  LEVDRLEELKMQ--NMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLH 334
              ++ ++ L  +  ++K++ E++++E  Q      +              +  ESL Q H
Sbjct: 919  QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD-IHDTVNMNIDTQEQLRNALESLKQ-H 976

Query: 335  DAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERK-----------ASDPNRFTN--R 381
               I  LK+  ++ +E+   +   E T     EF++K           A +    T   +
Sbjct: 977  QETINTLKS--KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVK 1034

Query: 382  GGNLLKEEK-------QRAKLQKML-------PKLEEELKARIELW-EQEHSKAFMVNGQ 426
               ++++++       ++ +LQ+ML        +L+ +LK  IE+  E +     + +  
Sbjct: 1035 DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL 1094

Query: 427  KFMEYVAEQWEMHRLEKE---------RAKQERQLKNKKQ 457
            K  + +  Q + H ++KE          A+ E +LK K Q
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 95/475 (20%), Positives = 207/475 (43%), Gaps = 61/475 (12%)

Query: 1    MRRSEVLAE--ESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEE 58
            +R +++L E  E +  + K  + LR + E + +  DQ       +K++++E +   + ++
Sbjct: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQ-------LKENLRETITRDLEKQ 1720

Query: 59   ESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERK 118
            E LK      + +  KE      +L     ++  E  I  ++KDL    + ++ Q  + +
Sbjct: 1721 EELK-----IVHMHLKEHQETIDKLRGIVSEKTNE--ISNMQKDLEHSNDALKAQDLKIQ 1773

Query: 119  QELKL----LQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEF 174
            +EL++    L+EQ + + ++  +     D  S    +  N   +    ++E KA+  +  
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ-L 1832

Query: 175  VSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEA 234
            +++K+ +    +++        ++ +  +      L +EN+   QKL   LE  KS  + 
Sbjct: 1833 ITLKKDVNETQKKVSEMEQ--LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890

Query: 235  VCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNM---- 290
                 R  +R + + L++   ER+ +   +  +KA+      LE+   +ELK   M    
Sbjct: 1891 -----RDNLRRVEETLKL---ERDQLKESLQETKAR-----DLEIQ--QELKTARMLSKE 1935

Query: 291  -KKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEV-H 348
             K+ ++ +R ++ +   Q    Q+          +   E  LQ  + +++R+K    + H
Sbjct: 1936 HKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQE--LQKKELQLLRVKEDVNMSH 1993

Query: 349  KELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKA 408
            K++ E  Q  ++     L  +    D  + T +    L+E +  AK +  L +++E LK 
Sbjct: 1994 KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK- 2052

Query: 409  RIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEML 463
                 E++   A +       E +A   + H+++ E+    R L + +Q  TE L
Sbjct: 2053 ----MERDQFIATL------REMIARDRQNHQVKPEK----RLLSDGQQHLTESL 2093



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 54/246 (21%), Positives = 102/246 (41%), Gaps = 28/246 (11%)

Query: 7   LAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDM-------MIAEEE 59
           L + + V  Q   N L    EL+   EDQ  +  E +     E + M        I + +
Sbjct: 562 LVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPK 621

Query: 60  SLKERLIKSISVC---QKELNTLCSE-LHVEPFQEEGETTILQLEKDLRTQVELMRKQKK 115
            +K+ L  + +V    ++E   L SE L ++   +E  TT  Q+E D++     +  +KK
Sbjct: 622 QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681

Query: 116 ERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFV 175
            +    K LQ    E+ ++  +    +    + +LE        +T L++      EE  
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLE----LEGKITDLQKELNKEVEENE 737

Query: 176 SIKRQIILCMEELDHTP-----------DTSFERDVVCEDED-AFCLSLENIATLQKLLR 223
           +++ ++IL + EL   P           D S E  ++  ++D  F   +   + +Q LL 
Sbjct: 738 ALREEVIL-LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE 796

Query: 224 QLEMQK 229
           ++   K
Sbjct: 797 EIGKTK 802


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 123/515 (23%), Positives = 208/515 (40%), Gaps = 114/515 (22%)

Query: 24   EIWELIGIPEDQRLQRTEVVKKHIKELLD-------MMIAEEESLKERLIKSISVCQKEL 76
            EIW L      + + R EV+KK    +L+         +AEE+   + L + +   Q +L
Sbjct: 919  EIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQL 978

Query: 77   NTLCSELHVEPFQEEGETTILQLEKD---------LRTQVELMRKQKKERKQELKLLQEQ 127
              L  E   +  QE     +L++E D         LR ++E +R+QK  R+ E+ LLQ++
Sbjct: 979  RALEQETR-DGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQR 1037

Query: 128  DQELCEILCMPHYDIDSASV------PSLE----ELNQFRQHVTTLRE----------TK 167
               L E        +    V      P LE    +L +  Q    LRE           K
Sbjct: 1038 VAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK 1097

Query: 168  ASRREEFVSIKRQIILCMEELDHTPDTSFERDV-----VCEDEDAFCLSLENIATLQKLL 222
              R E+  ++    I   E L    D + ER+V       EDE A   + +   T  +LL
Sbjct: 1098 LKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKT--ELL 1155

Query: 223  RQLEMQKSQNEAVCEGLRTQIRELWD------------RLQIPEEER------EAVATIM 264
            R++   + +N  V   ++ ++RE+              RL++ E+ER      E + +  
Sbjct: 1156 RKIWALEEENAKVV--VQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQ 1213

Query: 265  SGSKAKVRKALQLEVDRL--EELKMQ---NMKKVIEAIRVELVQYWDQCFYSQEQRQAFA 319
            S  +A  R+  Q+EV  +  E +K +    M+K ++ +R E+V                 
Sbjct: 1214 SELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIV----------------- 1256

Query: 320  PFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFT 379
                 D T  L++  D EI +LK   +  K+    VQ  +E  +  L+F+          
Sbjct: 1257 -----DKTR-LIERCDLEIYQLKKEIQALKDTKPQVQT-KEVVQEILQFQEDPQTKEEVA 1309

Query: 380  NRGGNLLKE-------EKQRAKLQKMLPKLEEEL---KARI---ELWEQEHSKAFMVNGQ 426
            +    L +E       E++RA  ++ + + EEEL   K R+   E+   E          
Sbjct: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369

Query: 427  KFMEYVAEQW--------EMHRLEKERAKQERQLK 453
             F E +  +         E+ RL++ R + ERQL+
Sbjct: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 78/395 (19%), Positives = 165/395 (41%), Gaps = 62/395 (15%)

Query: 100  EKDLRTQVELMRKQKKERKQELKLLQEQDQELCE-----ILCMPHYDIDSASVPSLEELN 154
            E D  +Q+E   K +K    E+   +++ Q++C         +  Y++++  + SL +L 
Sbjct: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815

Query: 155  QFR-QHV----------TTLRETKASRREEFV---SIKRQ----IILCMEELDHTPDTSF 196
              R  HV          T ++E +A+   +F    +I RQ    +   +  L   P+   
Sbjct: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875

Query: 197  ERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD-RLQIPEE 255
              + +  +          +    K+ ++L+ +  +   +   +++   E+W  R Q P+E
Sbjct: 876  THETLQRNRPD-----SGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQE 930

Query: 256  ---EREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQ 312
                +E +  +      +  + LQ  +   E+ K Q +++ +EA++++L          Q
Sbjct: 931  SVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQLLQEELEALQLQLRA------LEQ 983

Query: 313  EQRQAFAPFCAEDYTESLLQLHDA-EIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERK 371
            E R     +  ++          A E+++L+   E  +      QK      + L  +R 
Sbjct: 984  ETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRR-----QKGAREAEVLLLQQRV 1038

Query: 372  ASDPNRFTNRGGNLLKEEKQRAK---LQKMLPKLEE--ELKARIELWEQEHSKAFMVNGQ 426
            A+            L EEK RA+    +K + KL+   +L+A  +  +++H +   +  +
Sbjct: 1039 AA------------LAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK 1086

Query: 427  KFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETE 461
            +  E    Q ++ RLEKERA  E ++  K+  + E
Sbjct: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVE 1121


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 99/448 (22%), Positives = 195/448 (43%), Gaps = 35/448 (7%)

Query: 19  LNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
           ++ L + W+  G  E Q L      KK     ++ +  E ++L   L ++ ++  +EL  
Sbjct: 152 ISRLHDSWKFAGELE-QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKE 209

Query: 79  LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCM- 137
             ++L     QE+     LQL +  +++++L  K+ K + +  KLL  Q Q   E   + 
Sbjct: 210 KNAKL-----QEK-----LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 259

Query: 138 PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFE 197
                 SA + +  E N+    +   +E K  R+EE +  + + I   EE     +    
Sbjct: 260 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMR 319

Query: 198 R--DVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
           R  +++ E E+      E +   ++ +R+LE +  + E + E    +  E   R Q   +
Sbjct: 320 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 379

Query: 256 EREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
           E+EA    M   + K+R+  Q E  R +E  MQ  +   E +  +  + W+Q    QEQ 
Sbjct: 380 EQEAK---MWRQEEKIRE--QEEKIREQEEMMQEQE---EKMGEQEEKMWEQEEEMQEQE 431

Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
           +       E   E   ++ + E    +   E  + + E  +K  E      E E K  + 
Sbjct: 432 EKMRR-QEEKIREQEKKIREQE----EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ 486

Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIE--LWEQEHSKAFMVNGQKFMEYVA 433
                R    ++E++++ + Q+   + +EE+    E  +WEQE     M   ++ M+   
Sbjct: 487 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK---MCEQEEKMQ--E 541

Query: 434 EQWEMHRLEKERAKQERQLKNKKQTETE 461
           ++ +M R E++  +QE +L+ +++   E
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQE 569



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 67/313 (21%), Positives = 139/313 (44%), Gaps = 44/313 (14%)

Query: 15  LQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQK 74
           LQ   +HL +  + +      +++  E+  +  ++  + M  +EE ++ER          
Sbjct: 251 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER---------- 300

Query: 75  ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELM-RKQKKERKQELKLLQEQDQELCE 133
                      E   +E E  I + E+ +R Q E+M  K++K R+QE +++ E+++++ E
Sbjct: 301 -----------EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE-EMMWEKEEKIRE 348

Query: 134 ILCMPHYDIDSASVPSLEELNQFRQHVTTL-----RETKASRREEFVSIKRQIILCMEEL 188
           +    H   +   +   EE  Q  + +        +E K  R+EE +  + + I   EE+
Sbjct: 349 LEEKMH---EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEM 405

Query: 189 DHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD 248
                   + + + E E+      E +   ++ +R+ E +  + E        +IRE  +
Sbjct: 406 -----MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460

Query: 249 RLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVI----EAIR--VELV 302
            +Q  EE+       M   +AK+++  Q E  R +E K++  +K I    E IR   E++
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQE--QEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518

Query: 303 QYWDQCFYSQEQR 315
           Q  ++  + QE++
Sbjct: 519 QEQEEKMWEQEEK 531



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 76/374 (20%), Positives = 172/374 (45%), Gaps = 51/374 (13%)

Query: 108 ELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETK 167
           E +R++ + + Q +++L  Q  EL   L    +     +V  LE   + R  ++ L ++ 
Sbjct: 107 EALRRELEAQVQTIRILTCQKTELQMALYYSQH-----AVKQLE--GEARDLISRLHDSW 159

Query: 168 --ASRREEFVSI----KRQIILCMEELDHTPDT---SFERDVVCEDEDAFCLSLENIATL 218
             A   E+ +S     K++    +EEL    D       R+ + ++E       E  A L
Sbjct: 160 KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE-----LKEKNAKL 214

Query: 219 QKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLE 278
           Q+ L+ +E +KS+ +   + L+ ++     +L +P+++ +A A  +      V   LQ +
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERA--KLLLPQQQLQAEADHLGKELQSVSAKLQAQ 272

Query: 279 VD------RLEELKMQNMKKVIEAI--RVELVQYWDQCFYSQEQ---RQAFAPFCAEDYT 327
           V+      RL + + + M +  E I  R E +Q  ++    QE+   RQ    +  E+  
Sbjct: 273 VEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM 332

Query: 328 ---ESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGN 384
              E ++   + +I  L+      +++ E  +K +E  ++  E E++     +   +   
Sbjct: 333 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI-REQEKRQEQEAKMWRQEEK 391

Query: 385 LLKEEKQRAKLQKMLPKLEEELKARIE-LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEK 443
           + ++E++  + ++M+ + EE++  + E +WEQE             E   ++ +M R E+
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEE------------EMQEQEEKMRRQEE 439

Query: 444 ERAKQERQLKNKKQ 457
           +  +QE++++ +++
Sbjct: 440 KIREQEKKIREQEE 453



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 56/248 (22%), Positives = 112/248 (45%), Gaps = 30/248 (12%)

Query: 1   MRRSEVLA---EESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIK--ELLDMMI 55
           MRR E +    EE I  L++ ++   +I E     ++++ Q  E +++  K  E    M 
Sbjct: 332 MRRQEEMMWEKEEKIRELEEKMHEQEKIRE-----QEEKRQEEEKIREQEKRQEQEAKMW 386

Query: 56  AEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQ-- 113
            +EE ++E+  K      +E   +  E   E    E E  + + E++++ Q E MR+Q  
Sbjct: 387 RQEEKIREQEEKI-----REQEEMMQEQ--EEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439

Query: 114 ------KKERKQELKLLQEQD--QELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRE 165
                 KK R+QE K+ ++++  QE  E +      +        E+  + R+    +RE
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499

Query: 166 TKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQL 225
            +   RE+   I+ Q  +  E+ +   +   + + +CE E+      E +   ++ +R+ 
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQEEKMWE---QEEKMCEQEEKMQEQEEKMRRQEEKMREQ 556

Query: 226 EMQKSQNE 233
           E++  Q E
Sbjct: 557 EVRLRQQE 564


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 96/454 (21%), Positives = 196/454 (43%), Gaps = 59/454 (12%)

Query: 19  LNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
           ++ L + W+  G  E Q L      KK     ++ +  E ++L   L ++ ++  +EL  
Sbjct: 164 ISRLHDSWKFAGELE-QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKE 221

Query: 79  LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCM- 137
             ++L     QE+     LQL +  +++++L  K+ K + +  KLL  Q Q   E   + 
Sbjct: 222 KNAKL-----QEK-----LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271

Query: 138 PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFE 197
                 SA + +  E N+    +   +E K  R+EE +    + I   EE         +
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEE-----KIREQ 326

Query: 198 RDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEER 257
            + + E E+      E +   ++ +R+ E    + E   E +R Q   +W++    EE+ 
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE---EKMRRQEEMMWEK----EEKM 379

Query: 258 EAVATIMSGSKAKVR----KALQLEVDRLEELKMQNMKKVIEAIR--VELVQYWDQCFYS 311
                +M   + K+R    K  + E  R +E K Q  +K+ E  +   +  + W Q    
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 439

Query: 312 QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELF---EGVQKWEETWRLFLEF 368
           +EQ +       + + +   ++H+ E +R +   +  +E++   E + + EE WR     
Sbjct: 440 REQEEKIREQEKKMWRQE-EKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR----- 493

Query: 369 ERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIE-LWEQEHSKAFMVNGQK 427
                   +   +   + K+E++  + ++ + + EE+++ + E +W QE           
Sbjct: 494 -----QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQE----------- 537

Query: 428 FMEYVAEQWEMHRLEKERAKQERQLKNKKQTETE 461
             E + EQ EM R E++  +QE+  + +K+ E E
Sbjct: 538 --EKIREQEEMWREEEKMHEQEKIWEEEKRQEQE 569



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 89/453 (19%), Positives = 184/453 (40%), Gaps = 56/453 (12%)

Query: 24  EIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSEL 83
           E+W  +   +++++ R E   + I+E  + +  +EE ++E+  K     +K         
Sbjct: 289 ELWNRLNQQQEEKMWRQE---EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 345

Query: 84  HVEPFQEEGETTILQLEKDLRTQVELM-RKQKKERKQELKLLQEQDQELCEILCMPHYDI 142
             E      E  + + E+ +R Q E+M  K++K R+QE +++ E+++++ E+    H   
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE-EMMWEKEEKIRELEEKMH--- 401

Query: 143 DSASVPSLEELNQFRQHVTTL------------RETKASRREEFVSIKRQIILCMEELDH 190
           +   +   EE  Q  + +               +E K   +EE +  + + +   EE  H
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461

Query: 191 TPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRL 250
             +   E +   E E+ +    E I   +++ RQ E    Q E +    R Q  ++W + 
Sbjct: 462 EQEKIREEEKRQEQEEMWRQE-EKIHEQEEIWRQKEKMHEQEEKI----RKQEEKVWRQE 516

Query: 251 QIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFY 310
           +   E+ E +         +  K  + E    EE KM   +K+ E    E  Q  +   +
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE---EKRQEQEDKMW 573

Query: 311 SQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFER 370
            QE++         +  E + +  +    +++   E  +E  E + K EE  R   E E 
Sbjct: 574 RQEEK-------IREQEEKVWRQEE----KIREQEEKRQEQEEKMWKQEEKIR---EQEE 619

Query: 371 KASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFME 430
           K              ++E++++ + Q+   + +EE+    E    E  +      +K  E
Sbjct: 620 K--------------IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665

Query: 431 YVAEQWEMHRLEKERAKQERQLKNKKQTETEML 463
                W      +E+ K+ R+ + K + + EM+
Sbjct: 666 QEETMWRQEEKIREQEKKIREQEEKIREQEEMM 698



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 79/421 (18%), Positives = 179/421 (42%), Gaps = 39/421 (9%)

Query: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
           MRR E +  E    +++    + E  E +   E+   ++ E +++  +++ +     E+ 
Sbjct: 351 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 410

Query: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
            K +  + I   +K           E    E E  I + EK +  Q E + +Q+K R++E
Sbjct: 411 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 470

Query: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
               + Q+QE  E+        +   +   +E    ++     +E K  R+EE   I+ Q
Sbjct: 471 ----KRQEQE--EMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEE--KIREQ 522

Query: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNE--AVCEG 238
                E++    +  + ++    +++      E +   +K+  + + Q+ +++     E 
Sbjct: 523 ----EEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEK 578

Query: 239 LRTQIRELW---DRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIE 295
           +R Q  ++W   ++++  EE+R+     M   + K+R+  + ++   EE   +  +K+ E
Sbjct: 579 IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ-EEKIQEQEEKIREQEEKIRE 637

Query: 296 AIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGV 355
             + E+ Q  ++    QE++      C ++  E + +  +    + +   E  K++ E  
Sbjct: 638 --QEEMTQEQEEKMGEQEEK-----MCEQE--EKMQEQEETMWRQEEKIREQEKKIREQE 688

Query: 356 QKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQ 415
           +K  E   +  E E K  +            +EEK   + +KM  + E+  +   ++WEQ
Sbjct: 689 EKIREQEEMMQEQEEKMWE------------QEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 736

Query: 416 E 416
           E
Sbjct: 737 E 737


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 91/421 (21%), Positives = 186/421 (44%), Gaps = 61/421 (14%)

Query: 56  AEEESLKERLIKSISV---CQKELNTLCSELHVEPFQEEG----ETTILQLEKDLRTQVE 108
           AE + L + L +S+S     Q E N L + L+ +  QEE     E  I + E+ ++ Q E
Sbjct: 265 AEADHLGKEL-QSVSAKLQAQVEENELWNRLNQQ--QEEKMWRQEEKIQEWEEKIQEQEE 321

Query: 109 LMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKA 168
            +R+Q+++ +++ + ++ Q++ + E                 EE  + ++ +   +E K 
Sbjct: 322 KIREQEEKIREQEEKMRRQEEMMWE----------------KEEKMRRQEEMMWEKEEKM 365

Query: 169 SRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQ 228
            R EE +  K + I  +EE  H  +   E++   ++E+      +      K+ RQ E  
Sbjct: 366 RRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 425

Query: 229 KSQNEAVCEGLRTQIRELW-------DRLQIPEEEREAVATIMSGSKAKVRKALQLEVDR 281
           + Q E +    R Q +++W       ++ +I EEE+      M   + K+R+  Q E+ R
Sbjct: 426 REQEEKI----REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE--QEEIWR 479

Query: 282 LEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRL 341
            +E KM   +K    IR +  + W      QE++         D  E + +  +    + 
Sbjct: 480 QKE-KMHEQEK----IRKQEEKVW-----RQEEKM-------HDQEEKIREQEEKMWRQE 522

Query: 342 KNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPK 401
           +   E  +++ E  +K  E   +  E E K  +          + ++E++  + ++ + +
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE 582

Query: 402 LEEELKARIE-LWEQEHSKAFMVNGQKFMEYVAEQWEMHR--LEKERAKQERQLKNKKQT 458
            +E+++ + E +WEQE  +      +   E   + WE      E+E   QE++ K ++Q 
Sbjct: 583 QKEKIREQEEKIWEQE--EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 640

Query: 459 E 459
           E
Sbjct: 641 E 641



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 94/453 (20%), Positives = 189/453 (41%), Gaps = 44/453 (9%)

Query: 19  LNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
           ++ L + W+  G  E Q L      KK     ++ +  E ++L   L ++ ++  +EL  
Sbjct: 164 ISRLHDSWKFAGELE-QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKE 221

Query: 79  LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLL--QEQDQELCEILC 136
             ++L     QE+     LQL +  +++++L  K+ K + +  KLL  Q+Q Q   + L 
Sbjct: 222 KNAKL-----QEK-----LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271

Query: 137 MPHYDIDSASVPSLEE------LNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDH 190
                + +     +EE      LNQ ++     +E K    EE +  + + I   EE   
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331

Query: 191 TPDTSFER--DVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD 248
             +    R  +++ E E+      E +   ++ +R+LE    + E        +IREL +
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE-------KIRELEE 384

Query: 249 RLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVI----EAIRVELVQY 304
           ++   E+ RE         + +  K  + E  + +E KM   ++ I    E IR +  + 
Sbjct: 385 KMHEQEKIRE-----QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 439

Query: 305 WDQCFYSQEQRQAFAPFCAEDYTESLLQ----LHDAEIVRLKNYYEVHKELFEGVQK-WE 359
           W Q     EQ +       ++  E   Q        EI R K      +++ +  +K W 
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWR 499

Query: 360 ETWRLFLEFERKASDPNRFTNRGGNLLK-EEKQRAKLQKMLPKLEEELKARIELWEQEHS 418
           +  ++  + E+      +   +   + + EEK R + +K+  + E   +   ++ EQE  
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559

Query: 419 KAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQ 451
                  ++  E + EQ E  R +KE+ +++ +
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEE 592



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 58/259 (22%), Positives = 110/259 (42%), Gaps = 44/259 (16%)

Query: 215 IATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKA 274
           I  L K    L ++  +N    E L+ +  +L ++LQ+ E E+  +   +   K K+ +A
Sbjct: 195 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERA 254

Query: 275 --------LQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDY 326
                   LQ E D L + ++Q++   ++A +VE  + W++    QE++           
Sbjct: 255 KLLLPQQQLQAEADHLGK-ELQSVSAKLQA-QVEENELWNRLNQQQEEK----------- 301

Query: 327 TESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLL 386
                         +    E  +E  E +Q+ EE  R   E E K  +      R   ++
Sbjct: 302 --------------MWRQEEKIQEWEEKIQEQEEKIR---EQEEKIREQEEKMRRQEEMM 344

Query: 387 --KEEKQRAKLQKMLPKLEEELKARIELWEQEHS----KAFMVNGQKFMEYVAEQWEMHR 440
             KEEK R + + M  K E+  +    +WE+E      +  M   +K  E   ++ E  +
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 404

Query: 441 LEKERAKQERQLKNKKQTE 459
           + ++  +QE++ K  +Q E
Sbjct: 405 IREQEKRQEQEAKMWRQEE 423



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 43/233 (18%), Positives = 110/233 (47%), Gaps = 27/233 (11%)

Query: 33  EDQRLQRTEVVKKHIKELLDMMIAEEESL---KERLIKSISVCQKELNTLCSELHVEPFQ 89
           E++R ++ E+ ++  K      I E+E +   KE++ +   + ++E      E  +   +
Sbjct: 455 EEKRQEQEEMWRQEEK------IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE 508

Query: 90  E---EGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSAS 146
           E   E E  + + E+ +R Q E +R+Q+++ +++ +++QEQ++++ E             
Sbjct: 509 EKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGE------------Q 556

Query: 147 VPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDED 206
              ++E  + R+    +RE +   RE+   I+ Q     E+ +   +   + +++ E E+
Sbjct: 557 EEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE---QEEMMQEQEE 613

Query: 207 AFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREA 259
                 E +   ++ +++ E +  + E        ++R+  +++Q  +E  EA
Sbjct: 614 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 63/325 (19%), Positives = 136/325 (41%), Gaps = 15/325 (4%)

Query: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
           MRR E +  E    +++    + E  E +   E+   ++ E +++  +++ +     E+ 
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQE 396

Query: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
            K +  + I   +K           E    E E  I + EK +  Q E + +Q+K R++E
Sbjct: 397 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 456

Query: 121 LKLLQEQ-------DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREE 173
            +  QE+        +E  EI        +   +   EE    ++     +E K   +EE
Sbjct: 457 KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516

Query: 174 FVSIKRQIILCMEELDHTPDTSF--ERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQ 231
            +  + + I   EE     +     + +++ E E+      E +   +K+ RQ E  + Q
Sbjct: 517 KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQ 576

Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMK 291
            E + E  + +IRE  +++   EE+      +M   + K+ +  +   ++ E+++ Q   
Sbjct: 577 EEKIRE-QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-- 633

Query: 292 KVIEAIRVELVQYWDQCFYSQEQRQ 316
              E +R +  + W+Q    ++Q +
Sbjct: 634 ---EKMRRQEEKMWEQEVRLRQQEE 655


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)

Query: 38   QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
            +  E +K+  +E   + +A +E+ + R +    + Q+    L  ++  E  Q   E T L
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2325

Query: 98   QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
            + E       EL+++QK+  +++ + LQE  +++ + L               EE   F+
Sbjct: 2326 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2365

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
            + +   R+ +     E   +K ++   M       +   +R     +E    L    +AT
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424

Query: 218  LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
             +K  L++ LE+Q+ Q++   E LR  I EL       E E+E +         +  K L
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2469

Query: 276  QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
            QL+ + ++ ++ + + +  +A++   +   D    S  QR+ F     E     L QL  
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2521

Query: 336  AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
             E+ + +   E  +   +  Q  +E  RL    E   R+  +      R    L++ E+Q
Sbjct: 2522 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579

Query: 392  RAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R + +++L +  + L+ +++L E++H  A
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAA 2608



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)

Query: 75   ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
            EL TL S+ +++   E    T+ ++E++ R   E  R +++ER  E++   E+ ++L E 
Sbjct: 1325 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 135  LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                H    + +    +EL Q  Q     RE  A   ++    KR I   +++L  + + 
Sbjct: 1379 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1431

Query: 195  SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
                        ER  +  +E+   + L+  AT             L+    + E QK Q
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 232  NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
             +   E LR Q+++   R +  E E  +     + +  + ++ALQ LE  RL+  + +  
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551

Query: 291  KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
             +  E  R   VQ   +          Q +R +FA   A+   E  LQ     + +L+  
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1609

Query: 345  YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
             E             +E    +++W+    E  RL L+ E  A   +          KEE
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1668

Query: 390  KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
             +R   ++   K EE+   + EL EQE  K   +      + +A + E+ RL  E E+ +
Sbjct: 1669 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726

Query: 448  QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
            Q+RQL    + E   L   A     KR+ L         ++     S A A    R
Sbjct: 1727 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)

Query: 38   QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            QR E      +EL +       +AEE   + +L +  +  Q+        +  E     G
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1843

Query: 93   ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
            E T       L+T+ E+  K+K+   + L+ L E    Q + L E       DI+     
Sbjct: 1844 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1892

Query: 149  SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
              E L Q R+   +  E +    E+ +  +RQ+    EE       SFE+    + E   
Sbjct: 1893 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1943

Query: 209  CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
             L LE      N     +   Q E++ ++   +      + RE  +R+Q     EEE   
Sbjct: 1944 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002

Query: 257  -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
             R+A    +   KAKV +A +L  +R E+   + ++   EA +  L         ++E+ 
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2053

Query: 316  QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
             AFA    E   +  LQ   + + +L+   E  +      +  EE     ++ ER+A+  
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2107

Query: 376  NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
             R       L +  +++A+ +       E+L+      EQE ++          +  A  
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2164

Query: 436  WEMHRLEKERAKQERQLKNKKQTETEM 462
             EM   EK +   E+ L+ K Q E E+
Sbjct: 2165 AEM---EKHKKFAEQTLRQKAQVEQEL 2188



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)

Query: 1    MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
            M R++  AEE     +K    + E           +L RTE+    K  + + L++   +
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2440

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
             +   ERL ++I+  ++E   L           + E  +LQL+ +     E+   Q+++ 
Sbjct: 2441 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2484

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
             QE + LQ+      + L      I+      LE+L Q        LRE +  ++++   
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 177  IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
             +++++  MEE       +  R    E         E +   Q+ L+QLE Q+ Q E   
Sbjct: 2544 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2584

Query: 237  EGLRTQIRELWDRLQIPEEEREA 259
            E L  + + L ++LQ+ EE+  A
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRA 2607


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)

Query: 38   QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
            +  E +K+  +E   + +A +E+ + R +    + Q+    L  ++  E  Q   E T L
Sbjct: 2272 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2329

Query: 98   QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
            + E       EL+++QK+  +++ + LQE  +++ + L               EE   F+
Sbjct: 2330 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2369

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
            + +   R+ +     E   +K ++   M       +   +R     +E    L    +AT
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428

Query: 218  LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
             +K  L++ LE+Q+ Q++   E LR  I EL       E E+E +         +  K L
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2473

Query: 276  QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
            QL+ + ++ ++ + + +  +A++   +   D    S  QR+ F     E     L QL  
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2525

Query: 336  AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
             E+ + +   E  +   +  Q  +E  RL    E   R+  +      R    L++ E+Q
Sbjct: 2526 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2583

Query: 392  RAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R + +++L +  + L+ +++L E++H  A
Sbjct: 2584 RRQQEELLAEENQRLREQLQLLEEQHRAA 2612



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)

Query: 75   ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
            EL TL S+ +++   E    T+ ++E++ R   E  R +++ER  E++   E+ ++L E 
Sbjct: 1329 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1382

Query: 135  LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                H    + +    +EL Q  Q     RE  A   ++    KR I   +++L  + + 
Sbjct: 1383 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1435

Query: 195  SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
                        ER  +  +E+   + L+  AT             L+    + E QK Q
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495

Query: 232  NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
             +   E LR Q+++   R +  E E  +     + +  + ++ALQ LE  RL+  + +  
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1555

Query: 291  KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
             +  E  R   VQ   +          Q +R +FA   A+   E  LQ     + +L+  
Sbjct: 1556 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1613

Query: 345  YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
             E             +E    +++W+    E  RL L+ E  A   +          KEE
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1672

Query: 390  KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
             +R   ++   K EE+   + EL EQE  K   +      + +A + E+ RL  E E+ +
Sbjct: 1673 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730

Query: 448  QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
            Q+RQL    + E   L   A     KR+ L         ++     S A A    R
Sbjct: 1731 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)

Query: 38   QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            QR E      +EL +       +AEE   + +L +  +  Q+        +  E     G
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1847

Query: 93   ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
            E T       L+T+ E+  K+K+   + L+ L E    Q + L E       DI+     
Sbjct: 1848 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1896

Query: 149  SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
              E L Q R+   +  E +    E+ +  +RQ+    EE       SFE+    + E   
Sbjct: 1897 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1947

Query: 209  CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
             L LE      N     +   Q E++ ++   +      + RE  +R+Q     EEE   
Sbjct: 1948 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2006

Query: 257  -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
             R+A    +   KAKV +A +L  +R E+   + ++   EA +  L         ++E+ 
Sbjct: 2007 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2057

Query: 316  QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
             AFA    E   +  LQ   + + +L+   E  +      +  EE     ++ ER+A+  
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2111

Query: 376  NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
             R       L +  +++A+ +       E+L+      EQE ++          +  A  
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2168

Query: 436  WEMHRLEKERAKQERQLKNKKQTETEM 462
             EM   EK +   E+ L+ K Q E E+
Sbjct: 2169 AEM---EKHKKFAEQTLRQKAQVEQEL 2192



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)

Query: 1    MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
            M R++  AEE     +K    + E           +L RTE+    K  + + L++   +
Sbjct: 2396 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2444

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
             +   ERL ++I+  ++E   L           + E  +LQL+ +     E+   Q+++ 
Sbjct: 2445 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2488

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
             QE + LQ+      + L      I+      LE+L Q        LRE +  ++++   
Sbjct: 2489 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547

Query: 177  IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
             +++++  MEE       +  R    E         E +   Q+ L+QLE Q+ Q E   
Sbjct: 2548 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2588

Query: 237  EGLRTQIRELWDRLQIPEEEREA 259
            E L  + + L ++LQ+ EE+  A
Sbjct: 2589 ELLAEENQRLREQLQLLEEQHRA 2611


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)

Query: 38   QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
            +  E +K+  +E   + +A +E+ + R +    + Q+    L  ++  E  Q   E T L
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2325

Query: 98   QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
            + E       EL+++QK+  +++ + LQE  +++ + L               EE   F+
Sbjct: 2326 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2365

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
            + +   R+ +     E   +K ++   M       +   +R     +E    L    +AT
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424

Query: 218  LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
             +K  L++ LE+Q+ Q++   E LR  I EL       E E+E +         +  K L
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2469

Query: 276  QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
            QL+ + ++ ++ + + +  +A++   +   D    S  QR+ F     E     L QL  
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2521

Query: 336  AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
             E+ + +   E  +   +  Q  +E  RL    E   R+  +      R    L++ E+Q
Sbjct: 2522 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579

Query: 392  RAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R + +++L +  + L+ +++L E++H  A
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAA 2608



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)

Query: 75   ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
            EL TL S+ +++   E    T+ ++E++ R   E  R +++ER  E++   E+ ++L E 
Sbjct: 1325 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1378

Query: 135  LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                H    + +    +EL Q  Q     RE  A   ++    KR I   +++L  + + 
Sbjct: 1379 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1431

Query: 195  SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
                        ER  +  +E+   + L+  AT             L+    + E QK Q
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491

Query: 232  NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
             +   E LR Q+++   R +  E E  +     + +  + ++ALQ LE  RL+  + +  
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551

Query: 291  KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
             +  E  R   VQ   +          Q +R +FA   A+   E  LQ     + +L+  
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1609

Query: 345  YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
             E             +E    +++W+    E  RL L+ E  A   +          KEE
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1668

Query: 390  KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
             +R   ++   K EE+   + EL EQE  K   +      + +A + E+ RL  E E+ +
Sbjct: 1669 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726

Query: 448  QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
            Q+RQL    + E   L   A     KR+ L         ++     S A A    R
Sbjct: 1727 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)

Query: 38   QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            QR E      +EL +       +AEE   + +L +  +  Q+        +  E     G
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1843

Query: 93   ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
            E T       L+T+ E+  K+K+   + L+ L E    Q + L E       DI+     
Sbjct: 1844 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1892

Query: 149  SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
              E L Q R+   +  E +    E+ +  +RQ+    EE       SFE+    + E   
Sbjct: 1893 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1943

Query: 209  CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
             L LE      N     +   Q E++ ++   +      + RE  +R+Q     EEE   
Sbjct: 1944 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002

Query: 257  -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
             R+A    +   KAKV +A +L  +R E+   + ++   EA +  L         ++E+ 
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2053

Query: 316  QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
             AFA    E   +  LQ   + + +L+   E  +      +  EE     ++ ER+A+  
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2107

Query: 376  NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
             R       L +  +++A+ +       E+L+      EQE ++          +  A  
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2164

Query: 436  WEMHRLEKERAKQERQLKNKKQTETEM 462
             EM   EK +   E+ L+ K Q E E+
Sbjct: 2165 AEM---EKHKKFAEQTLRQKAQVEQEL 2188



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)

Query: 1    MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
            M R++  AEE     +K    + E           +L RTE+    K  + + L++   +
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2440

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
             +   ERL ++I+  ++E   L           + E  +LQL+ +     E+   Q+++ 
Sbjct: 2441 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2484

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
             QE + LQ+      + L      I+      LE+L Q        LRE +  ++++   
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543

Query: 177  IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
             +++++  MEE       +  R    E         E +   Q+ L+QLE Q+ Q E   
Sbjct: 2544 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2584

Query: 237  EGLRTQIRELWDRLQIPEEEREA 259
            E L  + + L ++LQ+ EE+  A
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRA 2607


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)

Query: 38   QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
            +  E +K+  +E   + +A +E+ + R +    + Q+    L  ++  E  Q   E T L
Sbjct: 2236 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2293

Query: 98   QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
            + E       EL+++QK+  +++ + LQE  +++ + L               EE   F+
Sbjct: 2294 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2333

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
            + +   R+ +     E   +K ++   M       +   +R     +E    L    +AT
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392

Query: 218  LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
             +K  L++ LE+Q+ Q++   E LR  I EL       E E+E +         +  K L
Sbjct: 2393 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2437

Query: 276  QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
            QL+ + ++ ++ + + +  +A++   +   D    S  QR+ F     E     L QL  
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2489

Query: 336  AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
             E+ + +   E  +   +  Q  +E  RL    E   R+  +      R    L++ E+Q
Sbjct: 2490 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2547

Query: 392  RAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R + +++L +  + L+ +++L E++H  A
Sbjct: 2548 RRQQEELLAEENQRLREQLQLLEEQHRAA 2576



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)

Query: 75   ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
            EL TL S+ +++   E    T+ ++E++ R   E  R +++ER  E++   E+ ++L E 
Sbjct: 1293 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1346

Query: 135  LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                H    + +    +EL Q  Q     RE  A   ++    KR I   +++L  + + 
Sbjct: 1347 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1399

Query: 195  SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
                        ER  +  +E+   + L+  AT             L+    + E QK Q
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459

Query: 232  NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
             +   E LR Q+++   R +  E E  +     + +  + ++ALQ LE  RL+  + +  
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1519

Query: 291  KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
             +  E  R   VQ   +          Q +R +FA   A+   E  LQ     + +L+  
Sbjct: 1520 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1577

Query: 345  YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
             E             +E    +++W+    E  RL L+ E  A   +          KEE
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1636

Query: 390  KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
             +R   ++   K EE+   + EL EQE  K   +      + +A + E+ RL  E E+ +
Sbjct: 1637 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694

Query: 448  QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
            Q+RQL    + E   L   A     KR+ L         ++     S A A    R
Sbjct: 1695 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)

Query: 38   QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            QR E      +EL +       +AEE   + +L +  +  Q+        +  E     G
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1811

Query: 93   ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
            E T       L+T+ E+  K+K+   + L+ L E    Q + L E       DI+     
Sbjct: 1812 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1860

Query: 149  SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
              E L Q R+   +  E +    E+ +  +RQ+    EE       SFE+    + E   
Sbjct: 1861 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1911

Query: 209  CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
             L LE      N     +   Q E++ ++   +      + RE  +R+Q     EEE   
Sbjct: 1912 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1970

Query: 257  -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
             R+A    +   KAKV +A +L  +R E+   + ++   EA +  L         ++E+ 
Sbjct: 1971 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2021

Query: 316  QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
             AFA    E   +  LQ   + + +L+   E  +      +  EE     ++ ER+A+  
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2075

Query: 376  NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
             R       L +  +++A+ +       E+L+      EQE ++          +  A  
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2132

Query: 436  WEMHRLEKERAKQERQLKNKKQTETEM 462
             EM   EK +   E+ L+ K Q E E+
Sbjct: 2133 AEM---EKHKKFAEQTLRQKAQVEQEL 2156



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)

Query: 1    MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
            M R++  AEE     +K    + E           +L RTE+    K  + + L++   +
Sbjct: 2360 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2408

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
             +   ERL ++I+  ++E   L           + E  +LQL+ +     E+   Q+++ 
Sbjct: 2409 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2452

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
             QE + LQ+      + L      I+      LE+L Q        LRE +  ++++   
Sbjct: 2453 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511

Query: 177  IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
             +++++  MEE       +  R    E         E +   Q+ L+QLE Q+ Q E   
Sbjct: 2512 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2552

Query: 237  EGLRTQIRELWDRLQIPEEEREA 259
            E L  + + L ++LQ+ EE+  A
Sbjct: 2553 ELLAEENQRLREQLQLLEEQHRA 2575


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)

Query: 38   QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
            +  E +K+  +E   + +A +E+ + R +    + Q+    L  ++  E  Q   E T L
Sbjct: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2462

Query: 98   QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
            + E       EL+++QK+  +++ + LQE  +++ + L               EE   F+
Sbjct: 2463 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2502

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
            + +   R+ +     E   +K ++   M       +   +R     +E    L    +AT
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561

Query: 218  LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
             +K  L++ LE+Q+ Q++   E LR  I EL       E E+E +         +  K L
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2606

Query: 276  QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
            QL+ + ++ ++ + + +  +A++   +   D    S  QR+ F     E     L QL  
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2658

Query: 336  AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
             E+ + +   E  +   +  Q  +E  RL    E   R+  +      R    L++ E+Q
Sbjct: 2659 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2716

Query: 392  RAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R + +++L +  + L+ +++L E++H  A
Sbjct: 2717 RRQQEELLAEENQRLREQLQLLEEQHRAA 2745



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)

Query: 75   ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
            EL TL S+ +++   E    T+ ++E++ R   E  R +++ER  E++   E+ ++L E 
Sbjct: 1462 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1515

Query: 135  LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                H    + +    +EL Q  Q     RE  A   ++    KR I   +++L  + + 
Sbjct: 1516 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1568

Query: 195  SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
                        ER  +  +E+   + L+  AT             L+    + E QK Q
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628

Query: 232  NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
             +   E LR Q+++   R +  E E  +     + +  + ++ALQ LE  RL+  + +  
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1688

Query: 291  KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
             +  E  R   VQ   +          Q +R +FA   A+   E  LQ     + +L+  
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1746

Query: 345  YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
             E             +E    +++W+    E  RL L+ E  A   +          KEE
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1805

Query: 390  KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
             +R   ++   K EE+   + EL EQE  K   +      + +A + E+ RL  E E+ +
Sbjct: 1806 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863

Query: 448  QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
            Q+RQL    + E   L   A     KR+ L         ++     S A A    R
Sbjct: 1864 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)

Query: 38   QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            QR E      +EL +       +AEE   + +L +  +  Q+        +  E     G
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1980

Query: 93   ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
            E T       L+T+ E+  K+K+   + L+ L E    Q + L E       DI+     
Sbjct: 1981 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 2029

Query: 149  SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
              E L Q R+   +  E +    E+ +  +RQ+    EE       SFE+    + E   
Sbjct: 2030 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 2080

Query: 209  CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
             L LE      N     +   Q E++ ++   +      + RE  +R+Q     EEE   
Sbjct: 2081 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2139

Query: 257  -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
             R+A    +   KAKV +A +L  +R E+   + ++   EA +  L         ++E+ 
Sbjct: 2140 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2190

Query: 316  QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
             AFA    E   +  LQ   + + +L+   E  +      +  EE     ++ ER+A+  
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2244

Query: 376  NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
             R       L +  +++A+ +       E+L+      EQE ++          +  A  
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2301

Query: 436  WEMHRLEKERAKQERQLKNKKQTETEM 462
             EM   EK +   E+ L+ K Q E E+
Sbjct: 2302 AEM---EKHKKFAEQTLRQKAQVEQEL 2325



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)

Query: 1    MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
            M R++  AEE     +K    + E           +L RTE+    K  + + L++   +
Sbjct: 2529 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2577

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
             +   ERL ++I+  ++E   L           + E  +LQL+ +     E+   Q+++ 
Sbjct: 2578 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2621

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
             QE + LQ+      + L      I+      LE+L Q        LRE +  ++++   
Sbjct: 2622 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680

Query: 177  IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
             +++++  MEE       +  R    E         E +   Q+ L+QLE Q+ Q E   
Sbjct: 2681 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2721

Query: 237  EGLRTQIRELWDRLQIPEEEREA 259
            E L  + + L ++LQ+ EE+  A
Sbjct: 2722 ELLAEENQRLREQLQLLEEQHRA 2744


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)

Query: 38   QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
            +  E +K+  +E   + +A +E+ + R +    + Q+    L  ++  E  Q   E T L
Sbjct: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2303

Query: 98   QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
            + E       EL+++QK+  +++ + LQE  +++ + L               EE   F+
Sbjct: 2304 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2343

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
            + +   R+ +     E   +K ++   M       +   +R     +E    L    +AT
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402

Query: 218  LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
             +K  L++ LE+Q+ Q++   E LR  I EL       E E+E +         +  K L
Sbjct: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2447

Query: 276  QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
            QL+ + ++ ++ + + +  +A++   +   D    S  QR+ F     E     L QL  
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2499

Query: 336  AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
             E+ + +   E  +   +  Q  +E  RL    E   R+  +      R    L++ E+Q
Sbjct: 2500 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2557

Query: 392  RAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R + +++L +  + L+ +++L E++H  A
Sbjct: 2558 RRQQEELLAEENQRLREQLQLLEEQHRAA 2586



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)

Query: 75   ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
            EL TL S+ +++   E    T+ ++E++ R   E  R +++ER  E++   E+ ++L E 
Sbjct: 1303 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1356

Query: 135  LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                H    + +    +EL Q  Q     RE  A   ++    KR I   +++L  + + 
Sbjct: 1357 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1409

Query: 195  SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
                        ER  +  +E+   + L+  AT             L+    + E QK Q
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469

Query: 232  NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
             +   E LR Q+++   R +  E E  +     + +  + ++ALQ LE  RL+  + +  
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1529

Query: 291  KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
             +  E  R   VQ   +          Q +R +FA   A+   E  LQ     + +L+  
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1587

Query: 345  YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
             E             +E    +++W+    E  RL L+ E  A   +          KEE
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1646

Query: 390  KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
             +R   ++   K EE+   + EL EQE  K   +      + +A + E+ RL  E E+ +
Sbjct: 1647 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704

Query: 448  QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
            Q+RQL    + E   L   A     KR+ L         ++     S A A    R
Sbjct: 1705 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)

Query: 38   QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            QR E      +EL +       +AEE   + +L +  +  Q+        +  E     G
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1821

Query: 93   ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
            E T       L+T+ E+  K+K+   + L+ L E    Q + L E       DI+     
Sbjct: 1822 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1870

Query: 149  SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
              E L Q R+   +  E +    E+ +  +RQ+    EE       SFE+    + E   
Sbjct: 1871 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1921

Query: 209  CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
             L LE      N     +   Q E++ ++   +      + RE  +R+Q     EEE   
Sbjct: 1922 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980

Query: 257  -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
             R+A    +   KAKV +A +L  +R E+   + ++   EA +  L         ++E+ 
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2031

Query: 316  QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
             AFA    E   +  LQ   + + +L+   E  +      +  EE     ++ ER+A+  
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2085

Query: 376  NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
             R       L +  +++A+ +       E+L+      EQE ++          +  A  
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2142

Query: 436  WEMHRLEKERAKQERQLKNKKQTETEM 462
             EM   EK +   E+ L+ K Q E E+
Sbjct: 2143 AEM---EKHKKFAEQTLRQKAQVEQEL 2166



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)

Query: 1    MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
            M R++  AEE     +K    + E           +L RTE+    K  + + L++   +
Sbjct: 2370 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2418

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
             +   ERL ++I+  ++E   L           + E  +LQL+ +     E+   Q+++ 
Sbjct: 2419 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2462

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
             QE + LQ+      + L      I+      LE+L Q        LRE +  ++++   
Sbjct: 2463 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521

Query: 177  IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
             +++++  MEE       +  R    E         E +   Q+ L+QLE Q+ Q E   
Sbjct: 2522 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2562

Query: 237  EGLRTQIRELWDRLQIPEEEREA 259
            E L  + + L ++LQ+ EE+  A
Sbjct: 2563 ELLAEENQRLREQLQLLEEQHRA 2585


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)

Query: 38   QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
            +  E +K+  +E   + +A +E+ + R +    + Q+    L  ++  E  Q   E T L
Sbjct: 2254 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2311

Query: 98   QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
            + E       EL+++QK+  +++ + LQE  +++ + L               EE   F+
Sbjct: 2312 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2351

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
            + +   R+ +     E   +K ++   M       +   +R     +E    L    +AT
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2410

Query: 218  LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
             +K  L++ LE+Q+ Q++   E LR  I EL       E E+E +         +  K L
Sbjct: 2411 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2455

Query: 276  QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
            QL+ + ++ ++ + + +  +A++   +   D    S  QR+ F     E     L QL  
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2507

Query: 336  AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
             E+ + +   E  +   +  Q  +E  RL    E   R+  +      R    L++ E+Q
Sbjct: 2508 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2565

Query: 392  RAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R + +++L +  + L+ +++L E++H  A
Sbjct: 2566 RRQQEELLAEENQRLREQLQLLEEQHRAA 2594



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)

Query: 75   ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
            EL TL S+ +++   E    T+ ++E++ R   E  R +++ER  E++   E+ ++L E 
Sbjct: 1311 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1364

Query: 135  LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                H    + +    +EL Q  Q     RE  A   ++    KR I   +++L  + + 
Sbjct: 1365 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1417

Query: 195  SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
                        ER  +  +E+   + L+  AT             L+    + E QK Q
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477

Query: 232  NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
             +   E LR Q+++   R +  E E  +     + +  + ++ALQ LE  RL+  + +  
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1537

Query: 291  KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
             +  E  R   VQ   +          Q +R +FA   A+   E  LQ     + +L+  
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1595

Query: 345  YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
             E             +E    +++W+    E  RL L+ E  A   +          KEE
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1654

Query: 390  KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
             +R   ++   K EE+   + EL EQE  K   +      + +A + E+ RL  E E+ +
Sbjct: 1655 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712

Query: 448  QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
            Q+RQL    + E   L   A     KR+ L         ++     S A A    R
Sbjct: 1713 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)

Query: 38   QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            QR E      +EL +       +AEE   + +L +  +  Q+        +  E     G
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1829

Query: 93   ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
            E T       L+T+ E+  K+K+   + L+ L E    Q + L E       DI+     
Sbjct: 1830 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1878

Query: 149  SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
              E L Q R+   +  E +    E+ +  +RQ+    EE       SFE+    + E   
Sbjct: 1879 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1929

Query: 209  CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
             L LE      N     +   Q E++ ++   +      + RE  +R+Q     EEE   
Sbjct: 1930 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1988

Query: 257  -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
             R+A    +   KAKV +A +L  +R E+   + ++   EA +  L         ++E+ 
Sbjct: 1989 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2039

Query: 316  QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
             AFA    E   +  LQ   + + +L+   E  +      +  EE     ++ ER+A+  
Sbjct: 2040 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2093

Query: 376  NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
             R       L +  +++A+ +       E+L+      EQE ++          +  A  
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2150

Query: 436  WEMHRLEKERAKQERQLKNKKQTETEM 462
             EM   EK +   E+ L+ K Q E E+
Sbjct: 2151 AEM---EKHKKFAEQTLRQKAQVEQEL 2174



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)

Query: 1    MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
            M R++  AEE     +K    + E           +L RTE+    K  + + L++   +
Sbjct: 2378 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2426

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
             +   ERL ++I+  ++E   L           + E  +LQL+ +     E+   Q+++ 
Sbjct: 2427 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2470

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
             QE + LQ+      + L      I+      LE+L Q        LRE +  ++++   
Sbjct: 2471 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529

Query: 177  IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
             +++++  MEE       +  R    E         E +   Q+ L+QLE Q+ Q E   
Sbjct: 2530 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2570

Query: 237  EGLRTQIRELWDRLQIPEEEREA 259
            E L  + + L ++LQ+ EE+  A
Sbjct: 2571 ELLAEENQRLREQLQLLEEQHRA 2593


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)

Query: 38   QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
            +  E +K+  +E   + +A +E+ + R +    + Q+    L  ++  E  Q   E T L
Sbjct: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2352

Query: 98   QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
            + E       EL+++QK+  +++ + LQE  +++ + L               EE   F+
Sbjct: 2353 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2392

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
            + +   R+ +     E   +K ++   M       +   +R     +E    L    +AT
Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451

Query: 218  LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
             +K  L++ LE+Q+ Q++   E LR  I EL       E E+E +         +  K L
Sbjct: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2496

Query: 276  QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
            QL+ + ++ ++ + + +  +A++   +   D    S  QR+ F     E     L QL  
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2548

Query: 336  AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
             E+ + +   E  +   +  Q  +E  RL    E   R+  +      R    L++ E+Q
Sbjct: 2549 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2606

Query: 392  RAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R + +++L +  + L+ +++L E++H  A
Sbjct: 2607 RRQQEELLAEENQRLREQLQLLEEQHRAA 2635



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)

Query: 75   ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
            EL TL S+ +++   E    T+ ++E++ R   E  R +++ER  E++   E+ ++L E 
Sbjct: 1352 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1405

Query: 135  LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                H    + +    +EL Q  Q     RE  A   ++    KR I   +++L  + + 
Sbjct: 1406 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1458

Query: 195  SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
                        ER  +  +E+   + L+  AT             L+    + E QK Q
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518

Query: 232  NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
             +   E LR Q+++   R +  E E  +     + +  + ++ALQ LE  RL+  + +  
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1578

Query: 291  KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
             +  E  R   VQ   +          Q +R +FA   A+   E  LQ     + +L+  
Sbjct: 1579 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1636

Query: 345  YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
             E             +E    +++W+    E  RL L+ E  A   +          KEE
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1695

Query: 390  KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
             +R   ++   K EE+   + EL EQE  K   +      + +A + E+ RL  E E+ +
Sbjct: 1696 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753

Query: 448  QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
            Q+RQL    + E   L   A     KR+ L         ++     S A A    R
Sbjct: 1754 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)

Query: 38   QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            QR E      +EL +       +AEE   + +L +  +  Q+        +  E     G
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1870

Query: 93   ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
            E T       L+T+ E+  K+K+   + L+ L E    Q + L E       DI+     
Sbjct: 1871 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1919

Query: 149  SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
              E L Q R+   +  E +    E+ +  +RQ+    EE       SFE+    + E   
Sbjct: 1920 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1970

Query: 209  CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
             L LE      N     +   Q E++ ++   +      + RE  +R+Q     EEE   
Sbjct: 1971 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029

Query: 257  -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
             R+A    +   KAKV +A +L  +R E+   + ++   EA +  L         ++E+ 
Sbjct: 2030 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2080

Query: 316  QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
             AFA    E   +  LQ   + + +L+   E  +      +  EE     ++ ER+A+  
Sbjct: 2081 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2134

Query: 376  NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
             R       L +  +++A+ +       E+L+      EQE ++          +  A  
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2191

Query: 436  WEMHRLEKERAKQERQLKNKKQTETEM 462
             EM   EK +   E+ L+ K Q E E+
Sbjct: 2192 AEM---EKHKKFAEQTLRQKAQVEQEL 2215



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)

Query: 1    MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
            M R++  AEE     +K    + E           +L RTE+    K  + + L++   +
Sbjct: 2419 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2467

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
             +   ERL ++I+  ++E   L           + E  +LQL+ +     E+   Q+++ 
Sbjct: 2468 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2511

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
             QE + LQ+      + L      I+      LE+L Q        LRE +  ++++   
Sbjct: 2512 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570

Query: 177  IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
             +++++  MEE       +  R    E         E +   Q+ L+QLE Q+ Q E   
Sbjct: 2571 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2611

Query: 237  EGLRTQIRELWDRLQIPEEEREA 259
            E L  + + L ++LQ+ EE+  A
Sbjct: 2612 ELLAEENQRLREQLQLLEEQHRA 2634


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 99/486 (20%), Positives = 204/486 (41%), Gaps = 75/486 (15%)

Query: 2   RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESL 61
           R+ E L E+     +K      ++W      +++RL+  E     ++E  + M  +E+ L
Sbjct: 276 RQEEELREQE----KKIRKQEEKMWR-----QEERLREQE---GKMREQEEKMWRQEKRL 323

Query: 62  KERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQEL 121
           +E+        +KEL     EL  +    E E  + + E+ +  Q E MR+Q+++  ++ 
Sbjct: 324 REQ--------EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE 375

Query: 122 KLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQI 181
           + L EQ++++ E             +   EE  +  +    LRE K  R  E   +  Q+
Sbjct: 376 ERLWEQEKQMRE---------QEQKMRDQEE--RMWEQDERLRE-KEERMREQEKMWEQV 423

Query: 182 ILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRT 241
               EE         E++    D++      E I   +K +R+ E    + E   E ++ 
Sbjct: 424 EKMREE-----KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE---EKMQK 475

Query: 242 QIRELWDRLQIPEEEREAVATIMSGSKAKV--RKALQLEVDRL--EELKMQNMKKV---- 293
           Q   +W+     +EE+E     +   K K+  ++ +Q + +++  +E K+++ +++    
Sbjct: 476 QEENMWE-----QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530

Query: 294 -----IEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVH 348
                 E +R +  Q W+Q    ++Q Q    +  E+  E   Q  + +    +      
Sbjct: 531 KKMWRQEKMREQEDQMWEQEEKMRDQEQKM--WDQEERMEKKTQEQEKKTWDQEEKMREE 588

Query: 349 KELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLL--KEEKQRAKLQKMLPKLEEEL 406
           + + E  +K  E   +  E E K  +           +  +EEK + + +KM  + E+  
Sbjct: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMW 648

Query: 407 KARIELWEQ-----------EHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNK 455
           +   ++WEQ           EH K  M   +K  E   + WE  ++EK+  +QE++  ++
Sbjct: 649 EQEEKMWEQQRLPEQKEKLWEHEK--MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ 706

Query: 456 KQTETE 461
           ++   E
Sbjct: 707 EKMREE 712



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 94/466 (20%), Positives = 202/466 (43%), Gaps = 83/466 (17%)

Query: 9   EESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKS 68
           EE I   ++ +    E+W      +++++ R E     ++E  D M  +EE ++++  K 
Sbjct: 510 EEKIWEQEEKIRDQEEMWG-----QEKKMWRQE----KMREQEDQMWEQEEKMRDQEQKM 560

Query: 69  ISVCQKELNTLCSELHVEPFQEEG----ETTILQLEKDLRTQVELMRKQKKERKQELKLL 124
               ++ +     E   + + +E     E  + + EK +R + E+MR+Q+++ +++ + +
Sbjct: 561 WDQ-EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619

Query: 125 QEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILC 184
           QEQ++++ E                 EE  Q ++     +E K   +EE +  ++++   
Sbjct: 620 QEQEEKMWE----------------QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663

Query: 185 MEEL-DHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQI 243
            E+L +H  +   E++ + E E             +K+  Q +M+K   E        Q 
Sbjct: 664 KEKLWEH--EKMQEQEKMQEQE-------------EKIWEQEKMEKKTQE--------QE 700

Query: 244 RELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQ 303
           ++ WD+ ++ EEE       M   + K+R+  + E+ R +E KMQ  ++ ++    E+  
Sbjct: 701 KKTWDQEKMREEES------MREREKKMRE--EEEMMREQEEKMQEQEEKMQEQEEEM-- 750

Query: 304 YWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWR 363
            W+Q     EQ +                     +   K     H+++ E  + WE+  +
Sbjct: 751 -WEQEEKMWEQEEK--------------MWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEK 795

Query: 364 LFLEFERKASDPNRFTNRGGNLL-KEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFM 422
           +  + E+      +   +   +  +EEK   + +KM  + E+      ++W QE      
Sbjct: 796 MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEK 855

Query: 423 VNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAP 468
           + GQ+  E + EQ E  R ++E+ +++ + K + Q E     GS P
Sbjct: 856 MQGQE--EKMREQEEKMRGQEEKMREQEE-KMRGQEEKIYCVGSPP 898



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 89/429 (20%), Positives = 180/429 (41%), Gaps = 56/429 (13%)

Query: 41  EVVKKHIKELLDMM-IAEEESLKERL-IKSISVCQKELNTLCSELHVEPFQEEGETTILQ 98
           E +KK   EL + + +AE E  + +L +K +    +    L  ++     QEE       
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEM------ 274

Query: 99  LEKDLRTQVELMRKQKKERKQELKL------LQEQDQELCEILCMPHYDIDSASVPSLEE 152
                R + EL  ++KK RKQE K+      L+EQ+ ++ E        +        E+
Sbjct: 275 ----WRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE----QEEKMWRQEKRLREQ 326

Query: 153 LNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFER-DVVCEDEDAFCLS 211
             + R+    LRE K  R +E            E++    +  +E+ + + E E+     
Sbjct: 327 EKELREQEKELREQKELREQE------------EQMQEQEEKMWEQEEKMREQEEKMWRQ 374

Query: 212 LENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKV 271
            E +   +K +R+ E +    E        ++RE  +R++  E+  E V  +    K + 
Sbjct: 375 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434

Query: 272 RKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLL 331
               Q +  R +E KMQ  +++ E  R + ++  ++    QE++        +   E++ 
Sbjct: 435 ----QEKKTRDQEEKMQEEERIRE--REKKMREEEETMREQEEKM-------QKQEENMW 481

Query: 332 QLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQ 391
           +  + E  + +   E  ++L+E  +K +E      E E K  D      +   + ++EK 
Sbjct: 482 EQEEKE-WQQQRLPEQKEKLWE-QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM 539

Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEM-HRLEKERAKQER 450
           R +  +M  + E+      ++W+QE         +K  E   + W+   ++ +E   +ER
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWDQEERME-----KKTQEQEKKTWDQEEKMREEERMRER 594

Query: 451 QLKNKKQTE 459
           + K +++ E
Sbjct: 595 EKKMREEEE 603


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 101/435 (23%), Positives = 188/435 (43%), Gaps = 26/435 (5%)

Query: 33  EDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
           E++  ++ E V +  +E L     EEE  ++R ++      ++L     EL  E  +EE 
Sbjct: 242 EEKEWRKRETVLRKEEEKLQ----EEEPQRQRELQEEEEQLRKLER--QELRRERQEEEQ 295

Query: 93  ETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEE 152
           +   L+ E+ LR + E  R++++E ++E +  +EQ +E  E       + +        E
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE-ERREQQLRRE 354

Query: 153 LNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSL 212
             + R+     RE +  RRE+ +  ++Q+     E     +    R+     E       
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQL---RREQQLRREQQLRREQQLRREQQLRRE- 410

Query: 213 ENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSK--AK 270
           + +   Q+L R+ ++++ Q E   E    Q R    RL+  +EER         ++   +
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERR-EQRLKREQEERRDWLKREEETERHEQ 469

Query: 271 VRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESL 330
            R+  QL+ D+ EE + + +K   E  R +  +   Q    QE+R+       E+     
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529

Query: 331 LQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNR-FTNRGGNLLKEE 389
            +L   + +R +      +E  E + K EE  R  LE ER+     R    R   LLK E
Sbjct: 530 QRLRSEQQLRRE-----QEERREQLLKREEEKR--LEQERREQRLKREQEERRDQLLKRE 582

Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQE 449
           ++R + Q++  + EE L+ R++  E E  +      Q+      E+    +L K   ++E
Sbjct: 583 EER-RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 450 R---QLKNKKQTETE 461
           R   QL+ ++Q   E
Sbjct: 642 RRQQQLRREQQERRE 656



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 99/466 (21%), Positives = 193/466 (41%), Gaps = 48/466 (10%)

Query: 27  ELIGIPEDQRLQ---RTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSEL 83
           +L+   E++RL+   R + +K+  +E  D ++  EE  +++ +K     ++ L       
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ--EERLEQRLKRE 605

Query: 84  HVEPFQEEGETTILQLEKDLRTQVELMRKQ-KKERKQELKLLQEQDQELCEILCMPHYDI 142
            VE           +LE++ R +  L R++ ++ER+Q+L   +EQ++   + L     + 
Sbjct: 606 EVE-----------RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654

Query: 143 DSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVC 202
               +   EE  +  Q +   RE +  RRE+ ++ + Q           P   ++ +   
Sbjct: 655 REQRLKREEEEERLEQRLK--REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712

Query: 203 EDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVAT 262
           +   +   S       Q+  ++ E ++ + E+    L+ Q  E   R Q  EE+R     
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE---LQWQEEERAHRQQQEEEQRRDFTW 769

Query: 263 IMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC 322
                +   R   +L       L+ Q  ++    +R E  Q  +Q F  +E+ +      
Sbjct: 770 QWQAEEKSERGRQRLSAR--PPLREQRERQ----LRAEERQQREQRFLPEEEEKEQRRRQ 823

Query: 323 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEET-----------WRLFLEFERK 371
             +  + L  L + E ++ +   +  +E  +G+Q+ +E            WR  LE ERK
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883

Query: 372 ASDPNRFTNRGGNLLKEE--KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFM 429
                R T      L+E+  K++  LQ+   +L+ E + +    EQE         Q+  
Sbjct: 884 R---RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940

Query: 430 EYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRR 475
           E +  +    R  +ER +Q R+ K  +Q E ++L       P KRR
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLL----GEEPEKRR 982



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 93/486 (19%), Positives = 207/486 (42%), Gaps = 58/486 (11%)

Query: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
           +RR + L  E  +  ++ L   +++     +  +Q+L+R + +++  +E       E+E 
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442

Query: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKD-------LRTQVELMRKQ 113
            ++RL +     ++  + L  E   E  ++E     L+ +++       L+ + E  R+Q
Sbjct: 443 REQRLKRE---QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499

Query: 114 KKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREE 173
           ++ R+Q+L+  QE+ +E                +   EE  + +Q    LR  +  RRE+
Sbjct: 500 QERREQQLRREQEERRE--------------QRLKRQEEEERLQQR---LRSEQQLRREQ 542

Query: 174 FVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNE 233
               +R+ +L  EE         E+ +  E E+      + +   ++  RQ  +++ Q E
Sbjct: 543 --EERREQLLKREEEKRLEQERREQRLKREQEE----RRDQLLKREEERRQQRLKREQEE 596

Query: 234 AVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKV 293
            + + L+   RE  +RL+  EE RE    +      + R+   L+ +  EE + Q +++ 
Sbjct: 597 RLEQRLK---REEVERLE-QEERRE--QRLKREEPEEERRQQLLKSEEQEERRQQQLRR- 649

Query: 294 IEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFE 353
                 E  +  +Q    +E+ +        ++ E   +   AE    +   +  + +  
Sbjct: 650 ------EQQERREQRLKREEEEERLEQRLKREHEEERREQELAE----EEQEQARERIKS 699

Query: 354 GVQKWEETWRLFLEFERKASD----PNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKAR 409
            + KW+  W+L  E + + S     P +   +     +EEK+R +  ++  + +EE +A 
Sbjct: 700 RIPKWQ--WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL--QWQEEERAH 755

Query: 410 IELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPR 469
            +  E+E  + F    Q   +    +  +      R ++ERQL+ +++ + E  +     
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEE 815

Query: 470 TPSKRR 475
              +RR
Sbjct: 816 EKEQRR 821



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 81/410 (19%), Positives = 175/410 (42%), Gaps = 40/410 (9%)

Query: 57  EEESLKER-LIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKK 115
           +EE L+ R L++     ++E      E     FQEE E    + E  LR + E +++++ 
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 116 ERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFV 175
           +R++EL+  +EQ ++L         ++        ++  + R+     R+ +  RRE+  
Sbjct: 266 QRQRELQEEEEQLRKL------ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ-Q 318

Query: 176 SIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAV 235
             +R+     E+ +   +    R+     E       E     Q+L R+ E ++ + +  
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378

Query: 236 CEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIE 295
            E    + ++L    Q+  E+             ++R+  QL   R ++L+ +   +  +
Sbjct: 379 REQQLRREQQLRREQQLRREQ-------------QLRREQQLR--REQQLRREQQLRREQ 423

Query: 296 AIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGV 355
            +R E  +   +  + QE+R+       E+  + L +  + E    ++  E  K+  +  
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE----RHEQERRKQQLKRD 479

Query: 356 QKWE--ETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELW 413
           Q+ E  E W    E ER+     R         +  +QR K Q+   +L++ L++  +L 
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539

Query: 414 EQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEML 463
            ++  +          E + ++ E  RLE+ER  +E++LK +++   + L
Sbjct: 540 REQEER---------REQLLKREEEKRLEQER--REQRLKREQEERRDQL 578



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 95/447 (21%), Positives = 189/447 (42%), Gaps = 58/447 (12%)

Query: 31   IPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQE 90
            + E+QRL+R E  +K +K        EE+ L+         CQ+    L  +   +  +E
Sbjct: 1377 LEEEQRLRRQERERKFLK--------EEQQLR---------CQEREQQLRQDRDRKFREE 1419

Query: 91   EGETTILQLEKDLRTQVELMRKQKKERK---QELKLLQEQDQELCEILCMPHYDIDSASV 147
            E + +  + ++  R + + +R+Q++ERK   +E +L QE+ ++  E         +   +
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE---------EEQLL 1470

Query: 148  PSLEELNQFRQHVTT--LRETKASRREEFVSIKRQIILCMEELDHTPDTSF-ERDVVCED 204
               EE    RQ      L E +  RR+E     R+  L  +E    P+  F E +     
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE----PERKFLEEEQQLHR 1526

Query: 205  EDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIM 264
            +      L+    L++  R  + ++ ++    E    Q+R+  +  Q+  +ER+    + 
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE--EEQLRQEREEQQLSRQERDRKFRL- 1583

Query: 265  SGSKAKVRKALQLE--VDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC 322
               + KVR+  Q    ++  ++L+ Q  ++ +   R    +  +Q    +E++Q      
Sbjct: 1584 --EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641

Query: 323  AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE----RKASDPNRF 378
               + E   QL   E  +   +        +  +K+ E  +L  E E    R+     +F
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRH--------DRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693

Query: 379  TNRGGNLLKEEKQRAKLQ--KMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQW 436
                  L ++E++R  LQ  + L + E E K R E   ++ ++   +  Q+    + E+ 
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE- 1752

Query: 437  EMHRLEKERAKQERQLKNKKQTETEML 463
            E  R E+E  +  RQ +++K  E E L
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQL 1779



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 87/450 (19%), Positives = 179/450 (39%), Gaps = 50/450 (11%)

Query: 33   EDQRLQRTEVVKKHIKELLDMMIAEEES------LKERLIKSISVCQKELNTLCSELHVE 86
            E++RL++  + ++H +E  +  +AEEE       +K R+ K     + E +   S+++  
Sbjct: 664  EEERLEQ-RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722

Query: 87   PFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELC-------------- 132
            P ++EG+    + E+  R +   ++ Q++ER    +  +EQ ++                
Sbjct: 723  PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782

Query: 133  EILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEE----- 187
             +   P            EE  Q  Q      E K  RR +    ++++    EE     
Sbjct: 783  RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842

Query: 188  LDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC---EGLRTQIR 244
             +       E D + ED++      +     QK   QLE ++ +          L+ Q+R
Sbjct: 843  RERAQQLQEEEDGLQEDQER--RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900

Query: 245  ELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
            +    LQ  EEE      +    + K R+  Q    R EE   Q  ++++   R +  + 
Sbjct: 901  KEQQLLQEEEEE------LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954

Query: 305  WDQCFYSQEQR--QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETW 362
              +  Y ++++  Q       E+  +   Q  + +    +   +  ++L     + E   
Sbjct: 955  ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL----REEREK 1010

Query: 363  RLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFM 422
            R   E+ER+    +        LL+EE+++ +LQ+     E + +   EL ++E     +
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER----ERQYREEEELQQEEEQ---L 1063

Query: 423  VNGQKFMEYVAEQWEMHRLEKERAKQERQL 452
            +  ++      E    +R E+E  ++E QL
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQL 1093



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 102/494 (20%), Positives = 202/494 (40%), Gaps = 73/494 (14%)

Query: 27   ELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVE 86
            +L+G  E++  +R + +++  ++  ++   EE+ L+E   K     ++E    C E   E
Sbjct: 1062 QLLG--EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR---RQERERQCRE--EE 1114

Query: 87   PFQEEGETTILQLEKDLRTQVELMRKQKKE---RKQELKLLQEQDQELCEILCMPHYDID 143
              Q+E E  +L+ E++ R + EL R+ ++E   +++E +LL+E+ ++         Y  +
Sbjct: 1115 ELQQE-EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173

Query: 144  SASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSF----ERD 199
                   E+L +  Q        +  R EE +  +++     +E D   D  +    E++
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE-DQRSDLKWQWEPEKE 1232

Query: 200  VVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC------EGLRTQIRELWDRLQ-- 251
                D   +C   EN    Q    QL  ++SQ +         E  R Q R  W +    
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292

Query: 252  IPEEER----EAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQ 307
             PEEE+    E         K++  K L L  +R E+ + Q   +        L +  +Q
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQL-LREEREEKRRRQETDRKFREEEQLLQEREEQ 1351

Query: 308  CFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLE 367
                QE+ + F         +    L + + +R +       +  + ++  E   +L  +
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411

Query: 368  FERKASDPNRFTNRG--GNLLKEEKQRAKLQKMLPK-LEEELKARIE------------- 411
             +RK  +  +  +R       +EE+Q+ + Q+   K LEEE + R E             
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471

Query: 412  ------LWEQEHSKAFMVNGQ---------KFME-----------YVAEQWEMHRLEKER 445
                  L  QE  + F+   Q         KF E           ++ E+ ++HR +++R
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531

Query: 446  --AKQERQLKNKKQ 457
               ++E+QL+ +++
Sbjct: 1532 KFLQEEQQLRRQER 1545



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 96/449 (21%), Positives = 178/449 (39%), Gaps = 55/449 (12%)

Query: 36   RLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETT 95
            R QR   ++   ++  +     EE  KE+  +     +KEL  L  E   E  Q      
Sbjct: 791  REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE---EQLQRRERAQ 847

Query: 96   ILQLEKD-LRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELN 154
             LQ E+D L+   E  R Q++ R Q+ +   E++++               + P+L+E  
Sbjct: 848  QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY--------AKPALQE-- 897

Query: 155  QFRQHVTTLRETKAS-RREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLE 213
            Q R+    L+E +   +REE    +RQ     +E  +      E + + ++E+       
Sbjct: 898  QLRKEQQLLQEEEEELQREEREKRRRQ----EQERQYR-----EEEQLQQEEEQLLREER 948

Query: 214  NIATLQKLLRQLEMQKS--QNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKV 271
                 Q+  RQ    K   Q E    G   + R   +R +   EE E    +    +  +
Sbjct: 949  EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE----LQQEEEQLL 1004

Query: 272  RKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLL 331
            R+  + E  R +E + Q  KK       EL Q  +Q    + +++       +   E  L
Sbjct: 1005 RE--EREKRRRQEWERQYRKKD------ELQQEEEQLLREEREKRRLQERERQYREEEEL 1056

Query: 332  QLHDAEIV----------RLKNYYEVHKELF---EGVQKWEETWRLFLEFERKASDPNRF 378
            Q  + +++           L+  Y   +EL    E + + E   R   E ER+  +    
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116

Query: 379  TNRGGNLLKEEKQRAKLQKMLPKLEEELKARIE----LWEQEHSKAFMVNGQKFMEYVAE 434
                  LL+EE+++ + Q++  +  EE + + E    L E+   +      +++ E    
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176

Query: 435  QWEMHRLEKERAKQERQLKNKKQTETEML 463
            Q E  +L +E  ++ RQ + ++  E E L
Sbjct: 1177 QQEEEQLLREEQEKRRQERERQYREEEEL 1205



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 27/115 (23%), Positives = 56/115 (48%), Gaps = 17/115 (14%)

Query: 33   EDQRLQRTEVVKKHIKEL-------LDMMIAEEESLKERLIKSISVCQKELNTLCSELHV 85
            E+Q+L+R E  +K ++E        L+    EEE L++   +     Q+    +  E  +
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755

Query: 86   EPFQEEGETTILQLEKDLRTQVEL--------MRKQKKERK--QELKLLQEQDQE 130
             P +EE +    + ++  R + +L        +R Q+ +RK  +E +L QE++++
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 14/112 (12%)

Query: 33   EDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
            E+Q+L+R E  +K  +E       EE+ L+ +        +++L     E  + P Q +G
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819

Query: 93   ----ETTILQLEKD---LRTQ-------VELMRKQKKERKQELKLLQEQDQE 130
                E   LQLE+    LR +        E    Q+K R++E +L QE++Q+
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 89/432 (20%), Positives = 183/432 (42%), Gaps = 52/432 (12%)

Query: 43   VKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELH-------------VEPFQ 89
            VK+   E L   ++E    + +L + +SV + + + +  EL              V+   
Sbjct: 681  VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740

Query: 90   EEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPS 149
            +E E +I + EK L+ Q+  +    KER + LK  Q   + L   +     ++  AS   
Sbjct: 741  KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA-- 798

Query: 150  LEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEE----LDHTPDTSFERDVVCEDE 205
              +L+ F+ + +   E   +  E+   ++++++    E         +   ++  VC + 
Sbjct: 799  --KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856

Query: 206  DAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMS 265
            DA  + +      Q L++QLE Q S+ E   + L TQ+ E   +L+   +E+E    I+ 
Sbjct: 857  DAHKIQV------QDLMQQLEKQNSEMEQKVKSL-TQVYE--SKLEDGNKEQEQTKQILV 907

Query: 266  GSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELV-QYWDQCFYSQEQRQAFAPFCAE 324
                K    LQ+   + +E+++   K   +   + ++ + ++  F +QE++       A+
Sbjct: 908  ---EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964

Query: 325  DYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGN 384
            +  E+L +    +  +LK   E+     E  QK ++     LE  +  S     ++    
Sbjct: 965  EMQETLKKKLLDQEAKLKK--ELENTALELSQKEKQFNAKMLEMAQANSAG--ISDAVSR 1020

Query: 385  LLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKE 444
            L  E  Q+ +++ +      EL   I +WE+           K  +   E  E+H ++ +
Sbjct: 1021 L--ETNQKEQIESLTEVHRRELNDVISIWEK-----------KLNQQAEELQEIHEIQLQ 1067

Query: 445  RAKQE-RQLKNK 455
              +QE  +LK K
Sbjct: 1068 EKEQEVAELKQK 1079



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 99/457 (21%), Positives = 183/457 (40%), Gaps = 91/457 (19%)

Query: 22  LREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCS 81
           LR I EL      + LQ  +  KKH++E  D  + E++         ISV Q +++ L  
Sbjct: 186 LRRIAEL-----REELQMDQQAKKHLQEEFDASLEEKDQY-------ISVLQTQVSLLKQ 233

Query: 82  ELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYD 141
            L   P   +    + QLE     Q E+  K++        +++                
Sbjct: 234 RLRNGPMNVDVLKPLPQLEP----QAEVFTKEENPESDGEPVVE---------------- 273

Query: 142 IDSASVPSLEELNQ-FRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDV 200
            D  SV +LE L Q  ++    L+  K    E   S K Q  L   E +   +   ER  
Sbjct: 274 -DGTSVKTLETLQQRVKRQENLLKRCK----ETIQSHKEQCTLLTSEKEALQEQLDER-- 326

Query: 201 VCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAV 260
                                L++LE  K  + A    L TQ+R+  + ++  E+++   
Sbjct: 327 ---------------------LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK--- 362

Query: 261 ATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAP 320
             +++ +K ++ + L+++ + + +L            R  + Q   Q    +EQ++    
Sbjct: 363 GMVIAETKRQMHETLEMKEEEIAQL------------RSRIKQMTTQGEELREQKEKSER 410

Query: 321 FCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTN 380
              E+  ++L      E  R K   E+ +++ + ++K  E  R+ L+ E      +R   
Sbjct: 411 AAFEELEKALSTAQKTEEARRKLKAEMDEQI-KTIEKTSEEERISLQQEL-----SRVKQ 464

Query: 381 RGGNLLKE--EKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEM 438
              +++K+  E+Q AKLQK+    E+EL  +    EQE +K      ++F E +    E 
Sbjct: 465 EVVDVMKKSSEEQIAKLQKLH---EKELARK----EQELTKKLQTREREFQEQMKVALEK 517

Query: 439 HRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRR 475
            + E  +  QE++ +     E   L   A  T S+ +
Sbjct: 518 SQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 98/487 (20%), Positives = 196/487 (40%), Gaps = 92/487 (18%)

Query: 15   LQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKEL---LDMMIAEEESLKERLIKSISV 71
            L+  L  L E    + I   Q   + E  +  IK +   ++ ++ E+E+L          
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---------- 1323

Query: 72   CQKELNTLCSELHVEPFQEEGETTILQLEKDLR---TQVELMRKQKKERKQELKLLQEQ- 127
             QKE        + +    E E+ I QL+K+L      V LM+++ KE+K E+  L +Q 
Sbjct: 1324 -QKEGG------NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376

Query: 128  ---------------------------DQELCEILCMPH---YDIDSASVPSLEELNQFR 157
                                       D+E CE+L       + +D+ S   +  L Q  
Sbjct: 1377 TDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVD 1436

Query: 158  QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
                   E K   +  F   +  +     +L+     ++E+D             E I  
Sbjct: 1437 DWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD-------------EQINL 1483

Query: 218  LQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQL 277
            L++ L Q   +    +   E  ++++ +    L+   E +   A IM       +K +++
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE--TELKSQTARIMELEDHITQKTIEI 1541

Query: 278  EVDRLEELKMQNMKKVIEAIR-VELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDA 336
            E    E LK  N +K IE    V+ +Q++ +    ++ R        ++  E +L L + 
Sbjct: 1542 E-SLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR-------VKEAEEKILTLEN- 1592

Query: 337  EIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQ 396
            ++  +K   E  K+  E V    ++     E E KA + +R  +     L E K++A  +
Sbjct: 1593 QVYSMKAELETKKKELEHVNLSVKS----KEEELKALE-DRLESESAAKLAELKRKA--E 1645

Query: 397  KMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKK 456
            + +  ++++L +++E  E+++ K    +  +    + E+      E+E    E +LK+ +
Sbjct: 1646 QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER------EREVHILEEKLKSVE 1699

Query: 457  QTETEML 463
             +++E L
Sbjct: 1700 SSQSETL 1706



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 84/394 (21%), Positives = 163/394 (41%), Gaps = 67/394 (17%)

Query: 101  KDLRTQVELMRKQKKERKQELKLLQEQ-DQELCEILCMPHYDIDSASVPSLEELN----- 154
            K+L+ Q+EL  K+  E+ +++ LL+E+ DQ+     C+     D  S    +E N     
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520

Query: 155  --------QFRQHVTTLRETKASRREEFVSIKRQIIL----CMEELDHTPDTSFERDVVC 202
                    +   H+T       S  E   +  +Q  +     +++L H  +   E+D   
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580

Query: 203  EDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRT---QIRELWDRLQIPEEEREA 259
            ++ +   L+LEN   +  +  +LE +K + E V   +++   +++ L DRL+     + A
Sbjct: 1581 KEAEEKILTLEN--QVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLA 1638

Query: 260  VATIMSGSK-AKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAF 318
                 +  K A ++K L  +++  EE   +  +  +  +  +L +   +    +E+ ++ 
Sbjct: 1639 ELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS- 1697

Query: 319  APFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEG-VQKWEETWRLFLEFERKASDPNR 377
                    +E+L+    A+ V    Y E  +   +G VQK          +E K S   R
Sbjct: 1698 ---VESSQSETLIVPRSAKNVAA--YTEQEEADSQGCVQK---------TYEEKISVLQR 1743

Query: 378  FTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIE--------LWEQEHSKAFMVNGQKFM 429
                  NL ++EK    LQ++  + EE + +  E        L + EH++A     Q  +
Sbjct: 1744 ------NLTEKEK---LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794

Query: 430  EYVAEQWE----------MHRLEKERAKQERQLK 453
             ++ E+ E             +EKE  K   Q K
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK 1828



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 99/514 (19%), Positives = 202/514 (39%), Gaps = 87/514 (16%)

Query: 9    EESIVCLQKALNHLREIWELIGIPEDQRLQ-RTEVVKKHIKELLDMMIAEEESLKER-LI 66
            EE I  LQ+ L    ++ + +G  +++ +    E+  ++ + L+ +  AE +  +++ +I
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794

Query: 67   KSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQE 126
              +    +E N   S +  +  ++EG    +Q +++L    + ++K  +E++   ++L++
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQ 1854

Query: 127  QDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCME 186
            + +EL           DS  V         RQ     +E      EE  S K + +  ++
Sbjct: 1855 KIKEL-----------DSCLV---------RQ-----KEVHRVEMEELTS-KYEKLQALQ 1888

Query: 187  ELD-HTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRE 245
            ++D     T    +   E   +  +  + ++ ++     LE + +  E   + L  +I  
Sbjct: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948

Query: 246  LWDRLQIPEEEREAVATIMSGSKAKVRKA-LQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
            L   L++  +E +    I+     + R+  ++ E + LE      +K+++     +L Q 
Sbjct: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQ- 2007

Query: 305  WDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRL 364
                                   E  L++   E +      EV  EL E  Q  EET +L
Sbjct: 2008 ----------------------KEQELEMTIKETINKAQ--EVEAELLESHQ--EETNQL 2041

Query: 365  FLEFERKASDPNRFTNRGGNLL--KEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFM 422
              +   K  D  R   R   +L  +EE+  AK++ +  +LEE  K   +  EQE +    
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPG-- 2099

Query: 423  VNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTP 482
                       +   +  L+ + A++   + + K  E E             R    N  
Sbjct: 2100 ----------NDNVTIMELQTQLAQKTTLISDSKLKEQEF------------REQIHNLE 2137

Query: 483  GKARKLNTTTMSNATANSSIRPIFGGTVYHSPVS 516
             + +K       N  A +   P  GG +YH+ VS
Sbjct: 2138 DRLKKYE----KNVYATTVGTPYKGGNLYHTDVS 2167



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 61/263 (23%), Positives = 106/263 (40%), Gaps = 51/263 (19%)

Query: 2    RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHI-KELLDMMIAEEES 60
            R  + L +E IV LQK L  LR+          +  Q  E++KK   +E  + +  E+E 
Sbjct: 1937 REKQKLGKE-IVRLQKDLRMLRK----------EHQQELEILKKEYDQEREEKIKQEQED 1985

Query: 61   LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQ-LEKDLRTQVELMRKQKKERKQ 119
            L+ +   ++    +E NT  ++      ++E E TI + + K    + EL+   ++E  Q
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQK-----EQELEMTIKETINKAQEVEAELLESHQEETNQ 2040

Query: 120  ELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKR 179
             LK + E+D +L                         ++      E   +R EE  +  R
Sbjct: 2041 LLKKIAEKDDDL-------------------------KRTAKRYEEILDAREEEMTAKVR 2075

Query: 180  QIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGL 239
             +   +EEL        E++    +++        I  LQ  L Q     S ++   +  
Sbjct: 2076 DLQTQLEELQKKYQQKLEQEENPGNDNV------TIMELQTQLAQKTTLISDSKLKEQEF 2129

Query: 240  RTQIRELWDRLQIPEEEREAVAT 262
            R QI  L DRL+  + E+   AT
Sbjct: 2130 REQIHNLEDRLK--KYEKNVYAT 2150



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 109/534 (20%), Positives = 207/534 (38%), Gaps = 89/534 (16%)

Query: 15   LQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIK---SISV 71
            L + L H +E+ E     +D R++  E     ++  +  M AE E+ K+ L     S+  
Sbjct: 1562 LVQKLQHFQELGE----EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617

Query: 72   CQKELNTLCSELHVEP------FQEEGETTILQLEKDLRTQVELMRKQKK---------- 115
             ++EL  L   L  E        + + E  I  ++K L +Q+E   +Q K          
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677

Query: 116  -----ERKQELKLLQEQ----DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRET 166
                 ER++E+ +L+E+    +    E L +P    + A+    EE +  +  V    E 
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS-QGCVQKTYEE 1736

Query: 167  KASRREEFVSIKRQIILCM-EELDHTPDTSFE-----RDVVCEDEDAFCLSLENIATLQK 220
            K S  +  ++ K +++  + +E + T  + FE     ++ + + E A     E+ + +  
Sbjct: 1737 KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH 1796

Query: 221  LLRQLEMQKSQNEAVC------EGLRTQIR------ELWDRLQIPEEEREAVATIMSGSK 268
            L  +LE +  +   +       EG +  I+       ++D +Q   +E+E    I+    
Sbjct: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856

Query: 269  AKVRKAL--QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDY 326
             ++   L  Q EV R+E  ++ +  + ++A++             Q   +       E+ 
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQALQ-------------QMDGRNKPTELLEEN 1903

Query: 327  TESLLQLHDAEIVRLKNYYEVHKEL-FEGVQKWEETWRLFLEFERKASD----------- 374
            TE   + H  +   L N    H +L F+      E  +L  E  R   D           
Sbjct: 1904 TEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQE 1963

Query: 375  ----PNRFTNRGGNLLKEEKQRAKLQ--KMLPKLEEELKARIELWEQEHSKAFMVNGQKF 428
                   +       +K+E++  +L+    L +L  E   ++   EQE          K 
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKA 2023

Query: 429  MEYVAEQWEMHRLE-----KERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGL 477
             E  AE  E H+ E     K+ A+++  LK   +   E+L        +K R L
Sbjct: 2024 QEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 87/450 (19%), Positives = 197/450 (43%), Gaps = 37/450 (8%)

Query: 19  LNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
           ++ L + W+  G  E Q L      KK     ++ +  E ++L   L ++ ++  +EL  
Sbjct: 225 ISRLHDSWKFAGELE-QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKE 282

Query: 79  LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCM- 137
             ++L     QE+     LQL +  +++++L  K+ K + +  KLL  Q Q   E   + 
Sbjct: 283 KNAKL-----QEK-----LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 332

Query: 138 PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSF- 196
                 SA + +  E N+    +   +E K  R+EE +    + I   EE     +    
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392

Query: 197 -ERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
            + + +   E+      E +   ++++ + E +  + E +      +IREL +++   E+
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452

Query: 256 EREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVI----EAIRVELVQYWDQCFYS 311
            RE         + +  K  + E  + +E KM   ++ I    E IR +  + W Q    
Sbjct: 453 IRE-----QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKI 507

Query: 312 QEQRQAFAPFCAEDYTESLLQ----LHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLE 367
            EQ +       ++  E   Q        EI R K   ++H E  E ++K EE  +++ +
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE--KIH-EQEEKIRKQEE--KMWRQ 562

Query: 368 FERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQK 427
            E+      +   +   + ++E++  + ++ + + EE+++ + E+ +++  K     G++
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKM----GEQ 618

Query: 428 FMEYVAEQWEMHRLEKERAKQERQLKNKKQ 457
             +   ++ +M   E++  +QE +++ +++
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEK 648



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 91/423 (21%), Positives = 194/423 (45%), Gaps = 50/423 (11%)

Query: 56  AEEESLKERLIKSISV---CQKELNTLCSELHVEPFQEEG----ETTILQLEKDLRTQVE 108
           AE + L + L +S+S     Q E N L + L+ +  QEE     E  I + E+ ++ Q E
Sbjct: 326 AEADHLGKEL-QSVSAKLQAQVEENELWNRLNQQ--QEEKMWRQEEKIQEWEEKIQEQEE 382

Query: 109 LMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKA 168
            +R+Q+++ +++ + ++ Q++ + E                 EE  + ++ +   +E K 
Sbjct: 383 KIREQEEKIREQEEKMRRQEEMMWE----------------KEEKMRRQEEMMWEKEEKM 426

Query: 169 SRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQ 228
            R+EE +  K + I  +EE  H  +   E++   ++E+      +      K+ RQ E  
Sbjct: 427 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 486

Query: 229 KSQNEAVCEG---LRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEEL 285
           + Q E + E    +  Q  ++ ++ +I EEE+      M   + K+R+  Q E+ R +E 
Sbjct: 487 REQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE--QEEIWRQKE- 543

Query: 286 KMQNMKKVIEAIRVELVQYW--DQCFYSQEQR---QAFAPFCAEDYTESLLQLHDAEIVR 340
               + +  E IR +  + W  ++  + QE++   Q    +  E+      +    +  +
Sbjct: 544 ---KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK 600

Query: 341 LKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLP 400
           ++   E+ +E  E + + EE      E E K  +      R    ++E++++ + Q+   
Sbjct: 601 IREQEEMTQEQEEKMGEQEEK---MCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKI 657

Query: 401 KLEEELKARIE--LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQT 458
           + +EE+    E  +WEQE     M   ++ M+   ++ +M R E++  +QE +L+ +++ 
Sbjct: 658 REQEEMMQEQEEKMWEQEEK---MCEQEEKMQ--EQEEKMRRQEEKMWEQEVRLRQQEEK 712

Query: 459 ETE 461
             E
Sbjct: 713 MQE 715



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 58/259 (22%), Positives = 110/259 (42%), Gaps = 44/259 (16%)

Query: 215 IATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKA 274
           I  L K    L ++  +N    E L+ +  +L ++LQ+ E E+  +   +   K K+ +A
Sbjct: 256 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERA 315

Query: 275 --------LQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDY 326
                   LQ E D L + ++Q++   ++A +VE  + W++    QE++           
Sbjct: 316 KLLLPQQQLQAEADHLGK-ELQSVSAKLQA-QVEENELWNRLNQQQEEK----------- 362

Query: 327 TESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLL 386
                         +    E  +E  E +Q+ EE  R   E E K  +      R   ++
Sbjct: 363 --------------MWRQEEKIQEWEEKIQEQEEKIR---EQEEKIREQEEKMRRQEEMM 405

Query: 387 --KEEKQRAKLQKMLPKLEEELKARIELWEQEHS----KAFMVNGQKFMEYVAEQWEMHR 440
             KEEK R + + M  K E+  +    +WE+E      +  M   +K  E   ++ E  +
Sbjct: 406 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 465

Query: 441 LEKERAKQERQLKNKKQTE 459
           + ++  +QE++ K  +Q E
Sbjct: 466 IREQEKRQEQEAKMWRQEE 484



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 28/115 (24%), Positives = 63/115 (54%), Gaps = 10/115 (8%)

Query: 22  LREIWELIGIPEDQRLQRTEVVKKH---IKELLDMMIAEEESLKERLIKSISVCQKELNT 78
           +RE  E +   E++  ++ E +++    I+E  +M   +EE + E+  K   +C++E   
Sbjct: 573 IREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK---MCEQEEKM 629

Query: 79  LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCE 133
              E  +   +E+    I + EK +R Q E +R+Q++  +++ + + EQ++++CE
Sbjct: 630 QEQEEKMRRQEEK----IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 680



 Score = 33.9 bits (76), Expect = 0.46
 Identities = 60/325 (18%), Positives = 132/325 (40%), Gaps = 29/325 (8%)

Query: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
           MRR E +  E    +++    + E  E +   E+   ++ E +++  +++ +     E+ 
Sbjct: 398 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 457

Query: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
            K +  + I   +K           E    E E  I + E+ +  Q E + +Q+K R++E
Sbjct: 458 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE 517

Query: 121 LKLLQE----------QDQELCEILCMPHYDID------------SASVPSLEELNQFRQ 158
            +  QE          + +E+       H   +               +   EE  + ++
Sbjct: 518 KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQE 577

Query: 159 HVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSF--ERDVVCEDEDAFCLSLENIA 216
                +E K   +EE +  + + I   EE+    +     + + +CE E+      E + 
Sbjct: 578 EKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMR 637

Query: 217 TLQKLLRQLEMQ-KSQNEAVCEG---LRTQIRELWDRLQIPEEEREAVATIMSGSKAKVR 272
             ++ +R+ E + + Q E + E    ++ Q  ++W++ +   E+ E +       + +  
Sbjct: 638 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 697

Query: 273 KALQLEVD-RLEELKMQNMKKVIEA 296
           K  + EV  R +E KMQ  ++ +EA
Sbjct: 698 KMWEQEVRLRQQEEKMQEHQEHLEA 722


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 91/457 (19%), Positives = 194/457 (42%), Gaps = 47/457 (10%)

Query: 24  EIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSEL 83
           E+W      +++ L+  E   K I++  + M  +EE L+E+  K     +K         
Sbjct: 235 EMWR-----QEEELREQE---KKIRKQEEKMWRQEERLREQEGKMREQEEK--------- 277

Query: 84  HVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI---LCMPHY 140
                    E  + + EK+LR Q + +R+QKK R+QE + +QEQ++++ E    +     
Sbjct: 278 -----MRRQEKRLREQEKELREQEKELREQKKLREQE-EQMQEQEEKMWEQEEKMREQEE 331

Query: 141 DIDSASVPSLEELNQFRQHVTTLR--ETKASRREEFVSIKRQIILCMEELDHTPDTSFER 198
            +        E+  Q R+    +R  E +   ++E +  K + +   E++    +   E 
Sbjct: 332 KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEE 391

Query: 199 DVVCEDEDAFCLSLENIATLQKLLRQLE---MQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
           + + E E       E +   ++ +++ E    ++ + E   + L  Q  +LW++ ++ E+
Sbjct: 392 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 451

Query: 256 EREAVATIMSGSKAKVRKALQL-----EVDRLEELKMQN--MKKVIEAIRVELVQYWDQC 308
           E +     +   + K+R   ++     ++ R E+++ Q   M +  E +R +  + WDQ 
Sbjct: 452 EEK-----IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 506

Query: 309 FYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEF 368
               EQ +           +  +   + ++   K   E  K+ ++  +K  E  R+  E 
Sbjct: 507 ERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERM-RER 565

Query: 369 ERKASDPNRFTNRGGNLLKE--EKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQ 426
           E+K  +           ++E  EK R + +KM  + E+  +   ++WEQE          
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625

Query: 427 KFMEYVAEQWEM-HRLEKERAKQERQLKNKKQTETEM 462
           K  E     WE   +++++  K   Q +  ++ E +M
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM 662



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 107/497 (21%), Positives = 205/497 (41%), Gaps = 93/497 (18%)

Query: 2   RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESL 61
           R+ E L E+     +K      ++W      +++RL+  E     ++E  + M  +E+ L
Sbjct: 238 RQEEELREQE----KKIRKQEEKMWR-----QEERLREQE---GKMREQEEKMRRQEKRL 285

Query: 62  KERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQ-------- 113
           +E+  K +   +KEL         E   +E E  + + E+ +R Q E M +Q        
Sbjct: 286 REQE-KELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 344

Query: 114 KKERKQELKL------LQEQDQELCEIL-CMPHYDIDSASVPSLEELNQFRQHVTTLRET 166
           K+ R+QE K+      + EQD+ L E    M   +        ++E  + R+    +RE 
Sbjct: 345 KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404

Query: 167 KASRREEFVSIKRQIILCMEE---------LDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
           + + RE+   +++Q     E+         L    +  +E++ + E E+      E I  
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 464

Query: 218 LQ-------KLLRQLEMQKSQNEA--VCEGLRTQIRELWDRLQIPEEEREAVATIMSGSK 268
            +       K+ RQ +M++ +++     E +R Q +++WD+ +   E+ E +       +
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR 524

Query: 269 AKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTE 328
            + +K  Q E    EE K Q  +K          + WDQ    +E+ +            
Sbjct: 525 EQ-KKMWQQEEKMREEKKTQEQEK----------KTWDQEEKMREEER------------ 561

Query: 329 SLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKE 388
               + + E  +++   E+ +E  E +Q+ EE  R   E E K  +            +E
Sbjct: 562 ----MRERE-KKMREEEEMMREQEEKMQEQEEKMR---EQEEKMWEQEEKMQE-----QE 608

Query: 389 EKQRAKLQKMLPKLEEELKARIE--LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERA 446
           EK   + +KM  + EE+     E  +WEQE         +K  E   + WE     +E+ 
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQE---------EKMQEQEEKMWEQEEKMREQE 659

Query: 447 KQERQLKNKKQTETEML 463
           ++ R+ + K Q + E +
Sbjct: 660 EKMREQEEKMQGQEEKM 676



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 86/436 (19%), Positives = 184/436 (42%), Gaps = 41/436 (9%)

Query: 41  EVVKKHIKELLDMMIAEEESLKERL-IKSISVCQKELNTLCSELHVEPFQEEGETTILQL 99
           E+ KK+ +    + +AE E  + +L +K +    +    L  ++     QEE        
Sbjct: 184 ELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEM------- 236

Query: 100 EKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQH 159
               R + EL  ++KK RKQE K+ +++++            +        E+  + R+ 
Sbjct: 237 ---WRQEEELREQEKKIRKQEEKMWRQEER------------LREQEGKMREQEEKMRRQ 281

Query: 160 VTTLRETKASRREEFVSIKRQIIL--CMEELDHTPDTSFER-DVVCEDEDAFCLSLENIA 216
              LRE +   RE+   ++ Q  L    E++    +  +E+ + + E E+      E + 
Sbjct: 282 EKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341

Query: 217 TLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ 276
             +K +R+ E +    E        ++RE  +R++  E+  E    +    + + R+   
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401

Query: 277 LEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQ---- 332
            E +     + + M+K  E +  +  + W Q    +++ + +     ++  E + +    
Sbjct: 402 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461

Query: 333 LHDAEIV--RLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEK 390
           + D E +  + K  +   K   +  Q WE+  ++  + E+K  D           L+E++
Sbjct: 462 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM-RDQEQKMWDQEERMWEQDERLREKE 520

Query: 391 QRAKLQKML----PKLEEELKARIE---LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEK 443
           +R + QK +     K+ EE K + +    W+QE         ++  + + E+ EM R E+
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR-EQ 579

Query: 444 ERAKQERQLKNKKQTE 459
           E   QE++ K ++Q E
Sbjct: 580 EEKMQEQEEKMREQEE 595



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 89/420 (21%), Positives = 170/420 (40%), Gaps = 62/420 (14%)

Query: 16  QKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKE 75
           QK  +    +WE     +D+RL+  E   + ++E   M   EE+  +E  I+      +E
Sbjct: 352 QKMRDQEERMWE-----QDERLREKE---ERMREQEKMWEQEEKMQEEERIREREKKMRE 403

Query: 76  LNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEIL 135
                 E   E  Q++ E    Q EK+ + Q      ++KE+  E + +QEQ++++ E  
Sbjct: 404 EEETMREQE-EKMQKQEENMWEQEEKEWQQQ---RLPEQKEKLWEQEKMQEQEEKIWE-- 457

Query: 136 CMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTS 195
                 I        +E   +RQ     +E +   +EE +  + Q +   EE        
Sbjct: 458 --QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE------RM 509

Query: 196 FERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRE--LWDRLQ-I 252
           +E+D             E +   ++ +R+ +    Q E + E  +TQ +E   WD+ + +
Sbjct: 510 WEQD-------------ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556

Query: 253 PEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQ 312
            EEER      M   + K+R+  + E+ R +E KMQ  +   E +R +  + W+Q    Q
Sbjct: 557 REEER------MREREKKMRE--EEEMMREQEEKMQEQE---EKMREQEEKMWEQEEKMQ 605

Query: 313 EQRQAF----APFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEF 368
           EQ +           ++  + + +  +    + +   E  ++++E  +K  E      E 
Sbjct: 606 EQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 665

Query: 369 ERKASDPNRFTNRGGNLLK---------EEKQRAKLQKMLPKLEEELKARIELWEQEHSK 419
           E K              ++         EEK R + +KM  + E+      ++W QE  +
Sbjct: 666 EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMR 725



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 53/268 (19%), Positives = 124/268 (46%), Gaps = 27/268 (10%)

Query: 9   EESIVCLQKALNHLREIW--ELIGIPEDQRLQRTEVVKKHIKELLDM---MIAEEESLKE 63
           EE I   ++     +++W  E +   EDQ  ++ E ++   +++ D    M  ++E L+E
Sbjct: 459 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE 518

Query: 64  RLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKL 123
           +  +     QK++     ++  E   +E E      E+ +R + E MR+++K+ ++E ++
Sbjct: 519 KEERMRE--QKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE-ERMREREKKMREEEEM 575

Query: 124 LQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIIL 183
           ++EQ++++ E                 EE  + ++     +E K   +EE +  + + + 
Sbjct: 576 MREQEEKMQE----------------QEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619

Query: 184 CMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQI 243
             EE D   +   + +++ E E+      E +   ++ +R+ E +  + E   +G   ++
Sbjct: 620 EQEEEDKMQE---QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKM 676

Query: 244 RELWDRLQIPEEEREAVATIMSGSKAKV 271
           RE  +++Q  EE+       M G + K+
Sbjct: 677 REQEEKMQGQEEKMREQEEKMRGQEEKM 704



 Score = 29.6 bits (65), Expect = 8.6
 Identities = 27/131 (20%), Positives = 65/131 (49%), Gaps = 16/131 (12%)

Query: 1   MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
           MR  E +  E    +Q+    +RE  E +   E++  ++ E + +  +++ +    EE+ 
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ--EEEDK 626

Query: 61  LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
           ++E         Q+E+         E   +E E  + + E+ +R Q E MR+Q+++ + +
Sbjct: 627 MQE---------QEEMMW-----EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ 672

Query: 121 LKLLQEQDQEL 131
            + ++EQ++++
Sbjct: 673 EEKMREQEEKM 683


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 108/478 (22%), Positives = 203/478 (42%), Gaps = 84/478 (17%)

Query: 3    RSEVLAEESIVCLQKALNHL---REIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEE 59
            +  VLA+E +V +++AL+     R++ +       + L + E  +  ++  +  + AEE 
Sbjct: 674  KRSVLAKE-LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEA 732

Query: 60   SLKERLIK------SISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQ 113
            SL++ L K      S++  + +LN L ++L       E E + LQ  +    Q   + ++
Sbjct: 733  SLQDSLSKLSALNESLAQDKLDLNRLVAQL-------EEEKSALQGRQRQAEQEATVARE 785

Query: 114  KKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQ-FRQHVTTLRETKASRRE 172
            ++ER +EL+L QE  ++  E            S+   E+  +   Q + TLR  ++  +E
Sbjct: 786  EQERLEELRLEQEVARQGLE-----------GSLRVAEQAQEALEQQLPTLRHERSQLQE 834

Query: 173  EFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQN 232
            +   + RQ+    +EL+        R+   + E     +LE  A  ++ L +     +  
Sbjct: 835  QLAQLSRQLSGREQELEQA-----RREAQRQVE-----ALERAAREKEALAKEHAGLAVQ 884

Query: 233  EAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKK 292
                E     + E   RL++   E+EA    + GS  +V++ L     R E+L+ +    
Sbjct: 885  LVAAEREGRTLSEEATRLRL---EKEA----LEGSLFEVQRQLAQLEARREQLEAEGQAL 937

Query: 293  VI--EAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKE 350
            ++  E +  EL     Q   +QE+    A    E   + L+Q        L+     H+E
Sbjct: 938  LLAKETLTGELAGLRQQIIATQEK----ASLDKELMAQKLVQAEREAQASLREQRAAHEE 993

Query: 351  LFEGVQKWEE-TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKAR 409
              + +Q+ +E  WR                       + E +RA+LQ  L + +EEL AR
Sbjct: 994  DLQRLQREKEAAWR-----------------------ELEAERAQLQSQLQREQEELLAR 1030

Query: 410  IELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTE-TEMLYGS 466
            +E  ++E S+      Q       E+ E   L +   +Q   LK  ++T  +E L G+
Sbjct: 1031 LEAEKEELSEEIAALQQ-------ERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 141/653 (21%), Positives = 247/653 (37%), Gaps = 71/653 (10%)

Query: 2    RRSEVLAEESIVCLQKA-----LNHLREIWELIGIPEDQRLQRTEVVKKHIK-------E 49
            RR ++ AE   + L K      L  LR+  ++I   E   L +  + +K ++        
Sbjct: 926  RREQLEAEGQALLLAKETLTGELAGLRQ--QIIATQEKASLDKELMAQKLVQAEREAQAS 983

Query: 50   LLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVEL 109
            L +   A EE L +RL +      +EL    ++L  +  Q E E  + +LE +     E 
Sbjct: 984  LREQRAAHEEDL-QRLQREKEAAWRELEAERAQLQSQ-LQREQEELLARLEAEKEELSEE 1041

Query: 110  MRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKAS 169
            +   ++ER + L L + + Q+   +        +S      E+L   R  + T+      
Sbjct: 1042 IAALQQERDEGLLLAESEKQQALSLK-------ESEKTALSEKLMGTRHSLATISLEMER 1094

Query: 170  RREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQK 229
            ++ +  S + Q    +  L     TS  RD+  + E+A     + +  LQ+  R L  Q+
Sbjct: 1095 QKRDAQSRQEQDRSTVNAL-----TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149

Query: 230  SQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQ 288
                   E LRTQ+R L       E+ R+ +   +  ++ K+R++ +  EV R E  +++
Sbjct: 1150 DSCLREAEELRTQLRLL-------EDARDGLRRELLEAQRKLRESQEGREVQRQEAGELR 1202

Query: 289  NM----KKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
                   K  EA+R    +       ++ +R +      ED  + L  L +A     K  
Sbjct: 1203 RSLGEGAKEREALRRSNEELRSAVKKAESERISL-KLANEDKEQKLALLEEARTAVGKEA 1261

Query: 345  YEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPK--L 402
             E+   L E  +   E  R   E  R+    +    R G  L E + R  L +   K   
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR 1321

Query: 403  EEELKARIELWEQEHSKAFM-----VNGQKFMEYVAEQWEMHR-----LEKERAKQERQL 452
             E L  R  L + E S   M     V  +K  E   E     R     LE+ R  +++QL
Sbjct: 1322 RETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381

Query: 453  KNKKQTETEMLYGSAPRTPSKRRGL-----APNTPGKARKLNTTTMSNATANSSIRPIFG 507
             + +  E ++    A R  +   GL          G   +L    +    A + +  +  
Sbjct: 1382 DHARGLELKL---EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRS 1438

Query: 508  GTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTGRHGANKENLELN-GSILSGGYPGSAPL 566
                   + R P    +PV  S         +G    +   LE + GS      P ++P 
Sbjct: 1439 ALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPA 1498

Query: 567  QRNFSINSVASTYSEFAKDPSLSD-------SSTVGLQRELS--KASKSDATS 610
              +    +V     EF ++   +        + T  L R+L+  +A +  ATS
Sbjct: 1499 SPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATS 1551



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 75/352 (21%), Positives = 133/352 (37%), Gaps = 32/352 (9%)

Query: 81  SELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEIL--CMP 138
           S LH    Q +      +  +DL   +  +RKQ  + + E + L+EQ Q L +     M 
Sbjct: 526 SALHKRQLQVQDMRGRYEASQDL---LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQ 582

Query: 139 HYDIDSASVPSLEELNQF----RQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
            ++     V  L   N+     + ++    +    + EE    + ++    EEL    D 
Sbjct: 583 AHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDR 642

Query: 195 SFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRL---- 250
             E     E EDA          L++  RQLE  + +   + + L  ++RE   R     
Sbjct: 643 LEE-----EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL-VEVREALSRATLQR 696

Query: 251 -QIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCF 309
             +  E+ E    +      +V   L +   R EE  +Q+    + A+   L Q  D+  
Sbjct: 697 DMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQ--DKLD 754

Query: 310 YSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE 369
            ++   Q        +  +S LQ    +  +        +E  E ++  +E  R  LE  
Sbjct: 755 LNRLVAQL-------EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGS 807

Query: 370 -RKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
            R A        +    L+ E  R++LQ+ L +L  +L  R +  EQ   +A
Sbjct: 808 LRVAEQAQEALEQQLPTLRHE--RSQLQEQLAQLSRQLSGREQELEQARREA 857


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 84/367 (22%), Positives = 157/367 (42%), Gaps = 32/367 (8%)

Query: 109  LMRKQKKERKQEL---KLLQEQDQELCEILCMPHYDIDSASVPSL------EELNQFRQH 159
            L RK   +R+Q+L   K+LQ       ++     + + +   P L      EE+    + 
Sbjct: 794  LARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEE 853

Query: 160  VTTLRETKASRREEFVSIKR-QIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATL 218
            +  +RE + +       ++  Q  L  E+L        E ++  E E+           L
Sbjct: 854  LVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQEL 913

Query: 219  QKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLE 278
            +++   LE +  + E  C+ L+ + +++   +Q  EE+ E         +   R+ LQLE
Sbjct: 914  EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE--------EEESARQKLQLE 965

Query: 279  VDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAE- 337
                E      +KK+ E    E +   DQ     ++++      AE +T +L +  +   
Sbjct: 966  KVTTEA----KLKKLEE----EQIILEDQNCKLAKEKKLLEDRIAE-FTTNLTEEEEKSK 1016

Query: 338  -IVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQ 396
             + +LKN +E      E   + EE  R  LE  R+  + +  T+    + + + Q A+L+
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS-TDLSDQIAELQAQIAELK 1075

Query: 397  KMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHR-LEKERAKQERQLKNK 455
              L K EEEL+A +   E+E ++  M   +K  E  ++  E+   LE ERA + +  K K
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQKNMAL-KKIRELESQISELQEDLESERASRNKAEKQK 1134

Query: 456  KQTETEM 462
            +    E+
Sbjct: 1135 RDLGEEL 1141



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 106/432 (24%), Positives = 176/432 (40%), Gaps = 77/432 (17%)

Query: 52   DMMIAEEESLKERLIKSISVCQK--ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVEL 109
            +MM  EEE +K R  K ++   +  E+ TL S+L  E  Q + +   LQ E +L  + E 
Sbjct: 846  EMMAKEEELVKVRE-KQLAAENRLTEMETLQSQLMAEKLQLQEQ---LQAETELCAEAEE 901

Query: 110  MRKQKKERKQELKLL-------QEQDQELCEILCMPHYDID---SASVPSLEELNQFRQ- 158
            +R +   +KQEL+ +        E+++E C+ L      +          LEE    RQ 
Sbjct: 902  LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961

Query: 159  ----HVTTLRETKASRREEFVSIKRQIILCME-ELDHTPDTSFERDVVCEDEDAFCLS-L 212
                 VTT  + K    E+ +   +   L  E +L       F  ++  E+E +  L+ L
Sbjct: 962  LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021

Query: 213  EN-----IATLQKLLRQLEMQKSQNEAV---CEG-----------LRTQIRELWDRLQIP 253
            +N     I  L++ LR+ E Q+ + E      EG           L+ QI EL  +L   
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081

Query: 254  EEEREAVATIMSGSKAKVRKALQ---------------LEVDRLEELKMQNMKK----VI 294
            EEE +A    +    A+   AL+               LE +R    K +  K+     +
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141

Query: 295  EAIRVELVQYWDQCFYSQEQR--QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELF 352
            EA++ EL    D     QE R  +       +   E   + H+A+I  ++  +    E  
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE-- 1199

Query: 353  EGVQKWEETWRLFLEFER-KASDPNR-----------FTNRGGNLLKEEKQRAKLQKMLP 400
            E  ++ E+T R+    E+ K +  N               +G +  K +K  A+LQ++  
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259

Query: 401  KLEEELKARIEL 412
            K  E  + R EL
Sbjct: 1260 KFNEGERVRTEL 1271



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 98/443 (22%), Positives = 181/443 (40%), Gaps = 39/443 (8%)

Query: 36   RLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEP-FQEEGET 94
            +L++ E  K   +E L+    EEE  K  L K I+    ++  +  ++       E  E 
Sbjct: 1330 KLKQVEDEKNSFREQLE----EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385

Query: 95   TILQLEKDL----RTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSL 150
               +L+KDL    +   E +    K  K + +L QE D  L ++      D    S  +L
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL------DHQRQSACNL 1439

Query: 151  EE----LNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCED-E 205
            E+     +Q      T+    A  R+   +  R+       L    + + E+    E   
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499

Query: 206  DAFCLSLENIATLQ----KLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVA 261
              F   +E++ + +    K + +LE  K   E   E ++TQ+ EL D LQ  E+ +  + 
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559

Query: 262  TIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPF 321
              +   KA+  + LQ   ++ EE K Q +++V E +  EL           E++Q     
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE-MEAEL---------EDERKQRSMAV 1609

Query: 322  CAEDYTESLLQLHDAEIVRL-KNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTN 380
             A    E  L+  +A I    KN  E  K+L +   + ++  R     + +AS       
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL--DDTRASREEILAQ 1667

Query: 381  RGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHR 440
               N  K +   A++ ++  +L    +A+ +  ++    A  +        +A + E  R
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE-EKRR 1726

Query: 441  LEKERAKQERQLKNKKQTETEML 463
            LE   A+ E +L+ ++Q  TE++
Sbjct: 1727 LEARIAQLEEELE-EEQGNTELI 1748



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 66/312 (21%), Positives = 129/312 (41%), Gaps = 52/312 (16%)

Query: 16   QKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAE----------EESLKE-- 63
            +K    +R++ E+    ED+R QR+  V    K  +D+   E          +E++K+  
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641

Query: 64   RLIKSISVCQKELN-TLCSELHVEPFQEEGETTILQLEKDL-RTQVELMRKQKKERKQEL 121
            +L   +  C +EL+ T  S   +    +E E  +  +E ++ + Q EL   ++ +R+ + 
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ- 1700

Query: 122  KLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQI 181
               QE+D+   EI      +       +LEE  +    +  L E     +     I  ++
Sbjct: 1701 ---QERDELADEIA-----NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752

Query: 182  ILCMEELDH-TPDTSFERDVVCEDEDA----------FCLSLENI--------------- 215
                 ++D    D + ER    ++E+A            + L+ +               
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812

Query: 216  -ATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD-RLQIPEEEREAVATIMSGSKAKVR- 272
             A + +L  QL+ +  + +A C+ +R   ++L D  LQ+ +E R A        KA  R 
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRL 1872

Query: 273  KALQLEVDRLEE 284
            K L+ +++  EE
Sbjct: 1873 KQLKRQLEEAEE 1884


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 98/487 (20%), Positives = 200/487 (41%), Gaps = 55/487 (11%)

Query: 2   RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKK--HIKELLDMMIAEEE 59
           +R E + E++    ++ +  +++ W  +G    Q+     ++++  H    + M    E+
Sbjct: 137 KRQEKMNEKNYTFRKRVV--IKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEK 194

Query: 60  SLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQ 119
             KER   S+ + +   NT+  E   E   E  E   L+L +  +++++L  K  K + +
Sbjct: 195 LTKERDAPSLELYR---NTITDEELKEKNAELQEK--LRLVESEKSEIQLNVKDLKRKLE 249

Query: 120 ELKLLQEQDQELCEILCM-PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIK 178
             +LL  Q Q   E   +       SA + +  E N+    +   +E K  R+EE +  +
Sbjct: 250 RAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ-E 308

Query: 179 RQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQ-KLLRQLEMQKSQNEAVCE 237
           ++  +C +EL        + + +   E+      E I   + K+ RQ E  + Q E +  
Sbjct: 309 QEEKMCEQELKIRE----QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKI-- 362

Query: 238 GLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQN--MKKVIE 295
             R Q  ++W + +   E+ E +         +  K  + E  R E++  Q   M++  E
Sbjct: 363 --REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDE 420

Query: 296 AIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGV 355
            IR +  + W Q                    E + +L +    + +   EV +++ E  
Sbjct: 421 KIREQEEEMWRQ-------------------EEKIRELEEMMQDQEEKLREVEEKMQEEE 461

Query: 356 QKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQ 415
           +K +E        E K  +    T R   LLK+E++  + ++ + + EE      ++WEQ
Sbjct: 462 EKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEE------KMWEQ 515

Query: 416 EHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLK--------NKKQTETEMLYGSA 467
           E          +  E    + E+   ++E   QE++++         K   + E+L G+ 
Sbjct: 516 EEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAG 575

Query: 468 PRTPSKR 474
             + S+R
Sbjct: 576 RESGSQR 582



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 57/292 (19%), Positives = 135/292 (46%), Gaps = 39/292 (13%)

Query: 22  LREIWELIGIPEDQRLQRTEVVKKH---IKELLDMMIAEEESLKERLIKSISVCQKELNT 78
           +RE  E I   E++  ++ E +++    I+E  + M  +EE ++E+  K      ++   
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKK 414

Query: 79  LCSELHVEPFQEEG----ETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
           +  +      QEE     E  I +LE+ ++ Q E +R+ +++ ++E + +QEQ++++   
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI--- 471

Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                               Q ++     +E K  R+E+ +  + +I    E++    + 
Sbjct: 472 --------------------QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511

Query: 195 SFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPE 254
            +E++   ++++      E +   ++ +R+ E++  Q E   +    +++EL +RL    
Sbjct: 512 MWEQEEKMQEQE------EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLG 565

Query: 255 EEREAV--ATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
           ++ E +  A   SGS+        L+V+ L+  + Q++++  +  R  L QY
Sbjct: 566 QKAELLGGAGRESGSQRLPTLTPILQVE-LKSQEAQSLQQQQDHYRGHLQQY 616


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 97/464 (20%), Positives = 189/464 (40%), Gaps = 94/464 (20%)

Query: 9    EESIVCLQKALNHLREIWELI---------GIPEDQRLQRTEVVKK--HIKELLDMMIAE 57
            ++ +  L + L H +E   L+          + E  RL  TEV +K  HI+E+       
Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREV------- 1645

Query: 58   EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
                 + L++ +S  + ELN   SE   +    + E  I + E++L+  +  M K K E 
Sbjct: 1646 -----KSLLEELSFQKGELNVQISERKTQLTLIKQE--IEKEEENLQVVLRQMSKHKTEL 1698

Query: 118  KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSI 177
            K  L +LQ ++ EL  +                    Q  Q V+ L +T+ +  EE + +
Sbjct: 1699 KNILDMLQLENHELQGLKL------------------QHDQRVSELEKTQVAVLEEKLEL 1740

Query: 178  KRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCE 237
            +    +  ++     +  +++ ++  D+            LQ  +  L  +K   +  C+
Sbjct: 1741 ENLQQISQQQKG---EIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD 1797

Query: 238  GLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAI 297
                ++ +    L   EE  +   + +   +  VRK LQ E+D+L   K+ ++   I A+
Sbjct: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK-LQQELDQLNRDKL-SLHNDISAM 1855

Query: 298  RVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQK 357
            + +L          QE+R+A           SL +    E+  ++++  + K+      K
Sbjct: 1856 QQQL----------QEKREA---------VNSLQE----ELANVQDHLNLAKQDLLHTTK 1892

Query: 358  WEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEH 417
             ++   L  E  R   D + + NR  +  KEE+ +   Q+ L  L+ E++          
Sbjct: 1893 HQDV--LLSEQTRLQKDISEWANRFEDCQKEEETK---QQQLQVLQNEIE---------- 1937

Query: 418  SKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETE 461
                    +  ++ V ++    RL+KER  +E +L+  K T  E
Sbjct: 1938 --------ENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKE 1973



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 77/363 (21%), Positives = 145/363 (39%), Gaps = 68/363 (18%)

Query: 32  PEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEE 91
           P D +L+  E      +  L  +  E E  +++++++     +E   L   + ++   E 
Sbjct: 434 PLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRAT----EEFKQLEEAIQLKKISEA 489

Query: 92  GETTI-------LQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDS 144
           G+  +       LQL   LR +   +  Q +++KQE+   Q++ ++L             
Sbjct: 490 GKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDL------------Q 537

Query: 145 ASVPSLEELNQFRQHVTTLRETKA--------------SRREEFVSIKRQIILCMEELDH 190
            ++ SL+  +    H+   +  K               SR +E +S   +I    EE+  
Sbjct: 538 IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILS---RIAKETEEIKD 594

Query: 191 TPDTSFERDVVCEDEDAFCLSLENIAT-LQKLLRQLEMQKSQNEAVCEGLRTQIRELWDR 249
             +   E  +   +  A    LE + + LQ+ L  ++ Q +Q +  C  LR +   L  R
Sbjct: 595 LEEQLTEGQIAANE--ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQR 652

Query: 250 LQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCF 309
           L   E+ER+                 QLE+  ++    +NM+K +  +   L +  +   
Sbjct: 653 LTEVEQERD-----------------QLEIVAMD---AENMRKELAELESALQEQHEVNA 692

Query: 310 YSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE 369
             Q+ +   + + AE   E+ L L DAE  +LK   E    L    Q  +   +  LE E
Sbjct: 693 SLQQTQGDLSAYEAE--LEARLNLRDAEANQLKEELEKVTRL---TQLEQSALQAELEKE 747

Query: 370 RKA 372
           R+A
Sbjct: 748 RQA 750



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 117/595 (19%), Positives = 224/595 (37%), Gaps = 124/595 (20%)

Query: 18   ALNHLREIWELIGIPEDQR-----LQRTE----VVKKHIKELLDMMIAEEESLKERLIKS 68
            A N  +E+ EL    ++Q      LQ+T+      +  ++  L++  AE   LKE L K 
Sbjct: 670  AENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV 729

Query: 69   ISVCQKELNTLCSELHVE-----------PFQEEGETTILQLE---KDLRTQVELMRKQK 114
              + Q E + L +EL  E            F EE E    +L    K L+    L+++Q 
Sbjct: 730  TRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQL 789

Query: 115  K------------------------ERKQELKL-----------------LQEQDQELCE 133
            K                        E +++LKL                 L +  ++  E
Sbjct: 790  KDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSE 849

Query: 134  ILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPD 193
            IL    ++ D A V       + ++ +   +E  A+ +EEF    RQ      E     D
Sbjct: 850  ILARSKWERDEAQVRE----RKLQEEMALQQEKLATGQEEF----RQACERALEARMNFD 901

Query: 194  TSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIP 253
                   + + E+      EN+ +++++    ++Q  + +   E +  Q+REL  + ++ 
Sbjct: 902  KRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLE 961

Query: 254  EEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQE 313
            + + +     +     K++KA+    D+L   ++   K  ++++   +++   +     +
Sbjct: 962  DAKSQEQVFGLDKELKKLKKAVATS-DKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020

Query: 314  QRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKAS 373
            + + F+   A+   +  L   +AEI  L+N      E F             LE E+   
Sbjct: 1021 EAERFSRKAAQAARD--LTRAEAEIELLQNLLRQKGEQFR------------LEMEKTGV 1066

Query: 374  DPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVA 433
                 T     +L+ EK    +++   ++   L+  ++L   ++   F    +  +E +A
Sbjct: 1067 G----TGANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGF----ENVLEEIA 1117

Query: 434  EQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTM 493
            E      L +E + Q               Y S+   P KRRG     P       ++  
Sbjct: 1118 E------LRREVSYQND-------------YISSMADPFKRRGYWYFMPPPPSSKVSSHS 1158

Query: 494  SNATANSSIRPIFGGTVYHSPVSRLPP------SGSKPVAASTCSGKKTPRTGRH 542
            S AT +S +   +  +   +PV +  P       GS+P  AS        R+G H
Sbjct: 1159 SQATKDSGVGLKYSAS---TPVRKPRPGQQDGKEGSQPPPASGYWVYSPIRSGLH 1210



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 48/229 (20%), Positives = 98/229 (42%), Gaps = 19/229 (8%)

Query: 99   LEKDLRTQVELMRKQKKERKQE--LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQF 156
            LE ++    ++M+  K ++++E  ++  + Q ++  E L   H++ID      L+E    
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEEL---HHNIDDL----LQEKKSL 1373

Query: 157  RQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIA 216
               V  L  T   R+++   I   +   M EL+         D+V E E      L+  +
Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433

Query: 217  TLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD--------RLQIPEEEREAVATIMSGSK 268
             L++  R L   +S+     E  +  + +  D             E ER A  T ++  K
Sbjct: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493

Query: 269  AKVR-KALQLEVDRLEELKMQNMKKVIEAIRVELVQYWD-QCFYSQEQR 315
            A  + ++LQ +   LE+ K++  + + E  ++   +  D QC   ++++
Sbjct: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEK 1542



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 86/451 (19%), Positives = 183/451 (40%), Gaps = 59/451 (13%)

Query: 33  EDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
           +D +    +  K   ++ LD+M  + + L+ RL + +S   KE   +     +E    EG
Sbjct: 546 KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKD---LEEQLTEG 602

Query: 93  ETTILQ-LEKDLRTQVELMRK-------QKKERKQELKLLQEQDQELCEILCMPHYDIDS 144
           +    + L+KDL   +  +++       Q  + + E + L+++ + L + L     + D 
Sbjct: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662

Query: 145 ASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCED 204
             + +++  N  R+ +  L      + E   S+++       +L    +   E  +   D
Sbjct: 663 LEIVAMDAENM-RKELAELESALQEQHEVNASLQQT----QGDLS-AYEAELEARLNLRD 716

Query: 205 EDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIM 264
            +A  L  E    L+K+ R  ++++S  +A  E  R  ++    + Q  EE+ +  + + 
Sbjct: 717 AEANQLKEE----LEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSEL- 771

Query: 265 SGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAE 324
               AK+ K LQ + + L++ ++++ +  +  +   LV+  +      E R+       E
Sbjct: 772 ---HAKL-KHLQDDNNLLKQ-QLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826

Query: 325 DYTESLLQLHDAEIVRLKNYYEVHKELFE--GVQKWEETWRLFLEFERKASDPNRFTNRG 382
                 + +H    V  K+  ++ K+  E     KWE         ERK  +        
Sbjct: 827 ------MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR--ERKLQEE------- 871

Query: 383 GNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA---------FMVNGQKFMEYVA 433
              L++EK     ++     E  L+AR+   +++H            ++    K ME + 
Sbjct: 872 -MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQ 930

Query: 434 EQWEMHRLEKERAK-----QERQLKNKKQTE 459
              ++   E +  K     Q R+L+ KK+ E
Sbjct: 931 GLTDLQLQEADEEKERILAQLRELEKKKKLE 961



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 42/158 (26%), Positives = 69/158 (43%), Gaps = 25/158 (15%)

Query: 4   SEVLAEESIVCL----QKALNHLREIWELIGIP-----EDQRLQR--TEVVKKHIKELLD 52
           S +L E  +V L    Q  + HLR +  L G P       +  +R   E V++  ++L  
Sbjct: 222 SLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK 281

Query: 53  MMIAEEE--SLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELM 110
            MI  EE  S + R ++ I    K   +L  E  ++    E      +L+ DL T+ EL+
Sbjct: 282 KMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCE------ELKSDLNTKNELL 335

Query: 111 RKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVP 148
           +++  E  +  +   E +QEL        Y ID+   P
Sbjct: 336 KQKTIELTRACQKQYELEQELA------FYKIDAKFEP 367


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 98/487 (20%), Positives = 200/487 (41%), Gaps = 55/487 (11%)

Query: 2   RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKK--HIKELLDMMIAEEE 59
           +R E + E++    ++ +  +++ W  +G    Q+     ++++  H    + M    E+
Sbjct: 137 KRQEKMNEKNYTFRKRVV--IKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEK 194

Query: 60  SLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQ 119
             KER   S+ + +   NT+  E   E   E  E   L+L +  +++++L  K  K + +
Sbjct: 195 LTKERDALSLELYR---NTITDEELKEKNAELQEK--LRLVESEKSEIQLNVKDLKRKLE 249

Query: 120 ELKLLQEQDQELCEILCM-PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIK 178
             +LL  Q Q   E   +       SA + +  E N+    +   +E K  R+EE +  +
Sbjct: 250 RAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ-E 308

Query: 179 RQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQ-KLLRQLEMQKSQNEAVCE 237
           ++  +C +EL        + + +   E+      E I   + K+ RQ E  + Q E +  
Sbjct: 309 QEEKMCEQELKIRE----QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKI-- 362

Query: 238 GLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQN--MKKVIE 295
             R Q  ++W + +   E+ E +         +  K  + E  R E++  Q   M++  E
Sbjct: 363 --REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDE 420

Query: 296 AIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGV 355
            IR +  + W Q                    E + +L +    + +   EV +++ E  
Sbjct: 421 KIREQEEEMWRQ-------------------EEKIRELEEMMQDQEEKLREVEEKMQEEE 461

Query: 356 QKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQ 415
           +K +E        E K  +    T R   LLK+E++  + ++ + + EE      ++WEQ
Sbjct: 462 EKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEE------KMWEQ 515

Query: 416 EHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLK--------NKKQTETEMLYGSA 467
           E          +  E    + E+   ++E   QE++++         K   + E+L G+ 
Sbjct: 516 EEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAG 575

Query: 468 PRTPSKR 474
             + S+R
Sbjct: 576 RESGSQR 582



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 75/395 (18%), Positives = 160/395 (40%), Gaps = 59/395 (14%)

Query: 112 KQKKERKQELKLLQEQ--DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKAS 169
           +  K+ K+ LK +     D E  E   + H   +S  V S      F++    + E   +
Sbjct: 94  EDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKS-----SFKKRQEKMNEKNYT 148

Query: 170 RREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQ---LE 226
            R+  V  K  + L        P+ S   + +  D      ++     ++KL ++   L 
Sbjct: 149 FRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDH-----AVRMGTYIEKLTKERDALS 203

Query: 227 MQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKA--------LQLE 278
           ++  +N    E L+ +  EL ++L++ E E+  +   +   K K+ +A        LQ+E
Sbjct: 204 LELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVE 263

Query: 279 VDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESL----LQLH 334
            DRL + ++Q++   ++A +VE  + W+     QE++        ++  E +    L++ 
Sbjct: 264 ADRLGK-ELQSVSAKLQA-QVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321

Query: 335 DAEIVRLKNYYEVHKELFEGVQKWEETWRL---FLEFERKASDPNRFTNRGGNLLKEE-- 389
           + E    +   ++H++  +  ++ ++ WR      E E K  +      R    ++E+  
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE 381

Query: 390 ----------KQRAKLQKMLPKLEEEL---------------KARIELWEQEHSKAFMVN 424
                     +Q  K+++   K +E++               +   E+W QE     +  
Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE 441

Query: 425 GQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTE 459
             +  E    + E    E+E   QE++ K ++Q E
Sbjct: 442 MMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEE 476



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 57/292 (19%), Positives = 135/292 (46%), Gaps = 39/292 (13%)

Query: 22  LREIWELIGIPEDQRLQRTEVVKKH---IKELLDMMIAEEESLKERLIKSISVCQKELNT 78
           +RE  E I   E++  ++ E +++    I+E  + M  +EE ++E+  K      ++   
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKK 414

Query: 79  LCSELHVEPFQEEG----ETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
           +  +      QEE     E  I +LE+ ++ Q E +R+ +++ ++E + +QEQ++++   
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI--- 471

Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
                               Q ++     +E K  R+E+ +  + +I    E++    + 
Sbjct: 472 --------------------QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511

Query: 195 SFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPE 254
            +E++   ++++      E +   ++ +R+ E++  Q E   +    +++EL +RL    
Sbjct: 512 MWEQEEKMQEQE------EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLG 565

Query: 255 EEREAV--ATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
           ++ E +  A   SGS+        L+V+ L+  + Q++++  +  R  L QY
Sbjct: 566 QKAELLGGAGRESGSQRLPTLTPILQVE-LKSQEAQSLQQQQDHYRGHLQQY 616


>gi|81295809 pericentrin [Homo sapiens]
          Length = 3336

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 103/399 (25%), Positives = 167/399 (41%), Gaps = 53/399 (13%)

Query: 23  REIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKER---LIKSISVCQKELNTL 79
           R I+ +   P +QR   T    K  ++  ++ I + ES +E    L +S +V   EL  L
Sbjct: 195 RGIFTISDHPAEQRGMFT----KECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250

Query: 80  ---CSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERK-QELKLLQEQDQELCEIL 135
               S +H        E T   L+K+  T +  +R+    R+ QEL LLQ + Q   E+L
Sbjct: 251 RLSLSNMHTAQL----ELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELL 306

Query: 136 CMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTS 195
              H      +    E + +  Q    L+E   S  E+      QI+  ++E     D  
Sbjct: 307 REQH------AREKEEVVLRCGQEAAELKEKLQSEMEK----NAQIVKTLKE-----DWE 351

Query: 196 FERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
            E+D          L LEN+        Q EM+  QN+   E L  Q  EL    Q   +
Sbjct: 352 SEKD----------LCLENLRKELSAKHQSEMEDLQNQFQKE-LAEQRAELEKIFQDKNQ 400

Query: 256 EREAVATIMSGSKA---KVRKALQLEVDR-LEEL----KMQNMKKVIEAIRVELVQYWDQ 307
              A+  + S  +A   K+R+ LQ E  R LE+L    K    +K +E   ++   Y D 
Sbjct: 401 AERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELENLQ-ASYEDL 459

Query: 308 CFYSQEQ-RQAFAPF-CAEDYTESLLQLHDAEIVRLKNYYEVHK-ELFEGVQKWEETWRL 364
              SQE+ R+ ++    A    + L +LH+  + R     ++ + +  E  Q   E  +L
Sbjct: 460 KAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQL 519

Query: 365 FLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLE 403
            + FE+K  D  +       LL++  Q A+   +L  +E
Sbjct: 520 RIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVE 558



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 63/276 (22%), Positives = 114/276 (41%), Gaps = 41/276 (14%)

Query: 206 DAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMS 265
           +A  LSL N+ T Q  L Q  +QK +  A+     T++RE+     +     + +A + S
Sbjct: 248 EALRLSLSNMHTAQLELTQANLQKEKETAL-----TELREM-----LNSRRAQELALLQS 297

Query: 266 GSKAKVRKALQLEVDRLEELKM---QNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC 322
             + ++    +      EE+ +   Q   ++ E ++ E+ +        +E  ++    C
Sbjct: 298 RQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLC 357

Query: 323 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRG 382
            E+  + L   H +E+  L+N ++  KEL E  Q+         E E+   D N+     
Sbjct: 358 LENLRKELSAKHQSEMEDLQNQFQ--KELAE--QR--------AELEKIFQDKNQAERAL 405

Query: 383 GNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLE 442
            NL       +  Q  + KL E+L       + EH +       KF E  +E+ +   LE
Sbjct: 406 RNL------ESHHQAAIEKLREDL-------QSEHGRCLEDLEFKFKE--SEKEKQLELE 450

Query: 443 KERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLA 478
             +A  E  LK + Q E   L+       + R+ L+
Sbjct: 451 NLQASYE-DLKAQSQEEIRRLWSQLDSARTSRQELS 485



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 97/425 (22%), Positives = 156/425 (36%), Gaps = 96/425 (22%)

Query: 39   RTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG------ 92
            R   ++K +++L      E+   +++  K  S    ++  L SEL  +  Q  G      
Sbjct: 1403 REAALRKEVEDLTK----EQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458

Query: 93   -----ETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASV 147
                 E  +  L+K LR Q + M +Q  ER+ E +  Q++ Q L                
Sbjct: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRL---------------- 1502

Query: 148  PSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDA 207
                   Q RQ      +    R  +   +  ++ L  ++L    D   E  +  E  D 
Sbjct: 1503 -----EGQLRQ--AAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESAD- 1554

Query: 208  FCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGS 267
                           RQ+ MQ+ + + + E +   IR+   +LQ   EE E    I+ G 
Sbjct: 1555 ---------------RQVLMQEEEIKRL-EEMNINIRKKVAQLQ---EEVEKQKNIVKG- 1594

Query: 268  KAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYT 327
                     LE D+ E LK Q M  ++ A  ++      +C           P    + T
Sbjct: 1595 ---------LEQDK-EVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644

Query: 328  ESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLK 387
            +  L   ++E++ LK   E  K   E   K EE   L L+ + +    N  T      L+
Sbjct: 1645 QRALLRRESEVLDLKEQLEKMKGDLE--SKNEEILHLNLKLDMQ----NSQTAVSLRELE 1698

Query: 388  EEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAK 447
            EE    K+        EELKA IE   QE+ K                    RL+KE+A+
Sbjct: 1699 EENTSLKVIYTRSSEIEELKATIENL-QENQK--------------------RLQKEKAE 1737

Query: 448  QERQL 452
            +  QL
Sbjct: 1738 EIEQL 1742


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 111/501 (22%), Positives = 204/501 (40%), Gaps = 102/501 (20%)

Query: 12   IVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIA---EEESLKERLIKS 68
            I  LQ+ + HL+   E +   E +R +  +++    KE  ++ I    + +SL++RL + 
Sbjct: 631  ITSLQEEVKHLKHNLEKV---EGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQE 687

Query: 69   ISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQD 128
            ++   K      ++ H +  +E     + ++EK L        K+++E +++ +    Q 
Sbjct: 688  VNE-HKVTKARLTDKH-QSIEEAKSVAMCEMEKKL--------KEEREAREKAENRVVQI 737

Query: 129  QELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQI------- 181
            ++ C +L     D+D         L Q +Q +  L   K    +E  ++  Q+       
Sbjct: 738  EKQCSML-----DVD---------LKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783

Query: 182  ILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRT 241
            +L   EL      +FE D +   E       + I TL +  R LE + +Q      G   
Sbjct: 784  LLLQNELK---TQAFEADNLKGLEKQM---KQEINTLLEAKRLLEFELAQLTKQYRGNEG 837

Query: 242  QIRELWDRL-------------------QIPEEEREAVATIMSGSKAKVRKALQLEVDRL 282
            Q+REL D+L                   +I E+ RE +  I      K   A QL++   
Sbjct: 838  QMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAET 897

Query: 283  EELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQ------LHDA 336
            +    Q  + ++E    EL Q   +   +   RQ       +D+T S L+        D 
Sbjct: 898  KAESEQLARGLLEEQYFELTQESKKA--ASRNRQEITD---KDHTVSRLEEANSMLTKDI 952

Query: 337  EIVRLKNYYEVHKELFEGVQKWEETWRLFLE---------FERKASDPNRFTNRGGNLLK 387
            EI+R +N     +EL E ++K EE ++L  E         FE+  +       +  N L 
Sbjct: 953  EILRREN-----EELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLA 1007

Query: 388  E---------EKQRAKLQKMLPKLEEELKARIEL-WEQEHSKAFMVNGQKFM-----EYV 432
            E         ++++A  Q +  K +E  K ++EL  E+E     +V  QK +     + V
Sbjct: 1008 EIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV 1067

Query: 433  AEQWEMHRLEKERAKQERQLK 453
             E    + L+ + A +E  ++
Sbjct: 1068 EECAHRNELQMQLASKESDIE 1088


>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
          Length = 495

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 87/419 (20%), Positives = 170/419 (40%), Gaps = 45/419 (10%)

Query: 80  CSELHVEPFQEEGE---TTILQLEKDLRTQ------------VELMRKQKKERKQELKLL 124
           C +LHV+  +         ++Q E D R Q             EL  ++  ++ +E K L
Sbjct: 23  CKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRL 82

Query: 125 QEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILC 184
           +E   +  E L M    +   S+   +   Q R++   LRE +   +  +++ +R   + 
Sbjct: 83  KELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIA 142

Query: 185 MEELDHTPDTSFERDV----VCEDEDAFCLSLENIATLQK----------LLRQLEMQKS 230
             E D       +RD        +E    +  EN A  ++          L +QLE Q+ 
Sbjct: 143 --EKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEK 200

Query: 231 QNEAVCEGLRTQ-------IRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLE 283
           + +   E L  +       +R++++  Q+ ++++      M     + +K   L   +  
Sbjct: 201 KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKR 260

Query: 284 ELKMQNMKKVIEAIRVELVQYWDQCFYSQE---QRQAFAPFCAEDYTESLLQLHDAEIVR 340
           E   +  +K+IE   ++  +  D+    QE   +R        +   E L Q  D E VR
Sbjct: 261 EEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVR 320

Query: 341 LKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQK-ML 399
            + Y E   E+++   K E   +L  + E K     +   +   L   +++    +K ML
Sbjct: 321 QELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTML 380

Query: 400 PKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL-EKERAKQERQLKNKKQ 457
            K  E+   RIEL   +  +   +  ++ +E + E+     L +K+R  +E QL+ ++Q
Sbjct: 381 AKFAED--DRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQ 437



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 23/115 (20%), Positives = 58/115 (50%), Gaps = 13/115 (11%)

Query: 22  LREIWELIGIPEDQRLQRTEVVKKHIKELLDMMI-------AEEESLKERLIKSISVCQK 74
           +R+I+E   + + Q+L++   ++++I+E              E E    ++I+  ++ Q+
Sbjct: 220 VRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQ 279

Query: 75  ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQ 129
                 +++      +E E   LQL+  L  ++E M +Q+++ +Q  + L +++Q
Sbjct: 280 REEDRMAKV------QENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ 328


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 101/532 (18%), Positives = 221/532 (41%), Gaps = 58/532 (10%)

Query: 10   ESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLK---ERLI 66
            E++  +++ L    E  +++    +   Q T++  + +   +   + E + +K   E L+
Sbjct: 793  EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852

Query: 67   KSISVCQKELNTLCSEL-----HVEPFQEEGETTILQLEK-------DLRTQVELMRKQK 114
              +S  + +L+ +   L       E   ++G+  IL LEK        L+ Q+E   K++
Sbjct: 853  TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912

Query: 115  KERKQELKLLQEQDQEL-CEILCMPHYDIDSASV--PSLEELNQFRQHVTTLRETKASRR 171
            KE K+ L+  +E   +L  E+  M    I + +    + +E  Q + ++  L+++   ++
Sbjct: 913  KELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 972

Query: 172  EEFVSIKRQI---ILCMEELDHTPD---TSFERDVVCEDEDAFCLSLENIATLQKLLRQL 225
            ++  +++ ++   +L   EL++      T   +++  E E    L   N    Q+  +QL
Sbjct: 973  KQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ-NNYEKSQETFKQL 1031

Query: 226  EMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSG-----SKAKVRKALQLEVD 280
            +      E+     R  ++ + ++L + +E+  +    +        + K  KA   +  
Sbjct: 1032 QSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDS 1091

Query: 281  RLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVR 340
              +E ++Q   K ++ I+ E          S ++++           E +    + EI +
Sbjct: 1092 AKKEQQLQERCKALQDIQKE---------KSLKEKELVNEKSKLAEIEEIKCRQEKEITK 1142

Query: 341  LKNYYEVHK-ELFEGVQKWEETWRLF----LEFERKASDPNRFT---NRGGNLLKEEKQR 392
            L    + HK E  + +   ++  +L     LE + KA           R   +LK++ ++
Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202

Query: 393  AKLQKMLPKLEEELKARIELWEQE-HSKAFMVNGQKF-MEYVAEQWEMHRLEKE-RAKQE 449
             + +     +E+E K   E+ E+E   K    N  K  M+  A    +  ++KE ++ Q 
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262

Query: 450  RQLKNKKQT-----ETEMLYGSAPRTPSKRRGLAPNT---PGKARKLNTTTM 493
            R  + +KQT     E  +L  +      +RR L        G+  KL T  +
Sbjct: 1263 RVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL 1314



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 101/486 (20%), Positives = 213/486 (43%), Gaps = 64/486 (13%)

Query: 8    AEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIK 67
            A++ ++ L+ ++N L            +++ + ++  K   ELL    A + + +  L  
Sbjct: 612  AQDRVLSLETSVNELNSQLN----ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667

Query: 68   SISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQ 127
             +   Q  L     EL+    Q +  T  LQ +++  +Q+E   K+ KE+   L+   E+
Sbjct: 668  HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727

Query: 128  DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEE 187
             +   + L     ++ ++   +L++L Q RQ  T L E +A+   + + ++++I+     
Sbjct: 728  LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL-ELRATELSKQLEMEKEIV----- 781

Query: 188  LDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLE---MQKSQNEAVCEGLRTQIR 244
                  +S   D+  + E     +LE+I   QKL +Q E   + K   E + +  + Q  
Sbjct: 782  ------SSTRLDLQKKSE-----ALESIK--QKLTKQEEEKQILKQDFETLSQETKIQHE 828

Query: 245  ELWDRLQIPEEEREAVATIMSGSKAKVRK-ALQLEVDRLEELKMQNMKKVIEAIRVELVQ 303
            EL +R+Q          T+    K K+ K AL  E+  +++     + KV ++++    +
Sbjct: 829  ELNNRIQ---------TTVTELQKVKMEKEALMTELSTVKD----KLSKVSDSLKNSKSE 875

Query: 304  YWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE-TW 362
            +  +   +Q+ + A       D  ++  +L     V+++N  +  KEL + ++K +E + 
Sbjct: 876  FEKE---NQKGKAAIL-----DLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 927

Query: 363  RLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLE---EELKARIELWEQEHSK 419
            +L LE     S   +       L + EK+  +LQ  + +L+   E+ K +IE  + E   
Sbjct: 928  QLKLELN---SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984

Query: 420  AFMVNGQ---KFMEYVAEQWEMHRLEKERA-----KQERQLKNKKQTETEMLYGSAPRTP 471
            A +   +   K  + + +  +    EKE+        E+  +  KQ +++  YG      
Sbjct: 985  AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD-FYGRESELL 1043

Query: 472  SKRRGL 477
            + R+ L
Sbjct: 1044 ATRQDL 1049



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 99/436 (22%), Positives = 184/436 (42%), Gaps = 54/436 (12%)

Query: 57  EEESLKERLIKSISVCQKELN---TLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQ 113
           EE SL+E   + ++   +ELN   T+  +L  E  Q  G   +  L+K+L     LM   
Sbjct: 181 EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM 240

Query: 114 KKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREE 173
             ER++E + L+++ ++L          I        +   +   +V  L++ K+S  E 
Sbjct: 241 TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE- 299

Query: 174 FVSIKRQII---LCMEELDHTPDTSFERDVVCEDEDAFCLSLENI-ATL-QKLL--RQLE 226
            ++ K Q +   L  +E D+T         + E  +   +S +NI ATL QK L  +QL+
Sbjct: 300 -LTQKNQTLTENLLKKEQDYTK--------LEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350

Query: 227 MQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELK 286
            + S +E     +  ++ E  +  Q  +EE   V T     KA+  K LQ + +  E+  
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF-KQLQQQREEKEQHG 409

Query: 287 MQNMKKVIEAIRVELVQYWDQCFYS----QEQRQAFAPFCAE------DYTESLLQLHDA 336
           +Q ++  I  +  +L++   Q   +    +EQRQ  +    +      D    L +L + 
Sbjct: 410 LQ-LQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ 468

Query: 337 EIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNR-----GGNLLKEEKQ 391
              ++ N  E+  +L +  Q+ +E   L      K  +      +     G    K +  
Sbjct: 469 LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL 528

Query: 392 RAKLQK------MLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKER 445
            A LQK      +L K  E+L A+I+  E E +    +           Q + H L+++ 
Sbjct: 529 EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL-----------QEKNHTLQEQV 577

Query: 446 AKQERQLKNKKQTETE 461
            +   +LKN+ ++  +
Sbjct: 578 TQLTEKLKNQSESHKQ 593


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,211,948
Number of Sequences: 37866
Number of extensions: 1082076
Number of successful extensions: 7707
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 572
Number of HSP's that attempted gapping in prelim test: 5455
Number of HSP's gapped (non-prelim): 1948
length of query: 620
length of database: 18,247,518
effective HSP length: 108
effective length of query: 512
effective length of database: 14,157,990
effective search space: 7248890880
effective search space used: 7248890880
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.