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Search of human proteins with 4505373
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505373 NIMA-related kinase 2 [Homo sapiens]
(445 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 879 0.0
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 204 1e-52
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 204 2e-52
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 203 2e-52
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 203 2e-52
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 201 8e-52
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 192 4e-49
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 189 3e-48
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 188 7e-48
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 181 9e-46
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 181 9e-46
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 181 9e-46
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 173 2e-43
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 173 2e-43
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 168 1e-41
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 145 9e-35
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 136 3e-32
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 136 3e-32
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 136 3e-32
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 136 3e-32
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 136 3e-32
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 136 3e-32
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 136 4e-32
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 135 6e-32
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 135 6e-32
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 135 6e-32
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 135 6e-32
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 135 1e-31
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 135 1e-31
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 135 1e-31
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 879 bits (2270), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR 60
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
Sbjct: 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR 60
Query: 61 ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL 120
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
Sbjct: 61 ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL 120
Query: 121 TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP 180
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
Sbjct: 121 TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP 180
Query: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY 240
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
Sbjct: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY 240
Query: 241 SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS 300
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
Sbjct: 241 SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS 300
Query: 301 PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE 360
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
Sbjct: 301 PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE 360
Query: 361 RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA 420
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
Sbjct: 361 RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA 420
Query: 421 QLRAQALSDIEKNYQLKSRQILGMR 445
QLRAQALSDIEKNYQLKSRQILGMR
Sbjct: 421 QLRAQALSDIEKNYQLKSRQILGMR 445
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 204 bits (520), Expect = 1e-52
Identities = 110/271 (40%), Positives = 162/271 (59%), Gaps = 10/271 (3%)
Query: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
+ Y+V+ IG G++G+ + KSD K V KE+++ M EK+ EV LL ++KHP
Sbjct: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHP 61
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
NIV +++ + N L+IVMEYC+GGDL I + + E+ +L Q++L LK
Sbjct: 62 NIVAFFNSF--QENGRLFIVMEYCDGGDLMKRINR--QRGVLFSEDQILGWFVQISLGLK 117
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSFAKTFVGTPYYMS 184
H R +LHRD+K N+FL V KLGDFG+AR+LN+ A+T +GTPYY+S
Sbjct: 118 HIHDRK-----ILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLS 172
Query: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244
PE YN K+DIWSLGC+LYELC L PF + ++L KI + F I +S EL
Sbjct: 173 PEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSREL 232
Query: 245 NEIITRMLNLKDYHRPSVEEILENPLIADLV 275
+ +I+++ + RPS+ IL+ P + +L+
Sbjct: 233 HSLISQLFQVSPRDRPSINSILKRPFLENLI 263
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 204 bits (518), Expect = 2e-52
Identities = 113/267 (42%), Positives = 153/267 (57%), Gaps = 9/267 (3%)
Query: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
E Y L IG GS+G+ ++ DG+ V KE++ M+ E++ EV +L +KHP
Sbjct: 2 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 61
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
NIV+Y + + N +LYIVM+YCEGGDL I ++ E+ +L Q+ LALK
Sbjct: 62 NIVQYRESFEE--NGSLYIVMDYCEGGDLFKRIN--AQKGVLFQEDQILDWFVQICLALK 117
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
H R +LHRD+K N+FL V+LGDFG+AR+LN A+T +GTPYY+SP
Sbjct: 118 HVHDRK-----ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSP 172
Query: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
E YN KSDIW+LGC+LYELC L F A S K L KI G F + YS +L
Sbjct: 173 EICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLR 232
Query: 246 EIITRMLNLKDYHRPSVEEILENPLIA 272
+++++ RPSV ILE IA
Sbjct: 233 SLVSQLFKRNPRDRPSVNSILEKGFIA 259
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 203 bits (517), Expect = 2e-52
Identities = 133/377 (35%), Positives = 191/377 (50%), Gaps = 30/377 (7%)
Query: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
+DY VL IG GS+GR ++ +S ++ KE+ + + Q E LL ++KHP
Sbjct: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHP 60
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
NIV + + LYIVMEYC+GGDL I + ++ + E+ +L TQ+ L +
Sbjct: 61 NIVAFKESF--EAEGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVN 116
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
H++ VLHRD+K N+FL VKLGDFG AR+L++ +FA T+VGTPYY+ P
Sbjct: 117 HIHKKR-----VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPP 171
Query: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
E + YN KSDIWSLGC+LYELC L PF A S K L K+ +G +P YS EL
Sbjct: 172 EIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQ 231
Query: 246 EIITRMLNLKDYHRPSVEEILENPLIA---------DLVADEQRRNLER-RGRQLGEPEK 295
++ +M HRPS +L ++A +++ + LE + + P K
Sbjct: 232 FLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRK 291
Query: 296 SQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNY 355
+ S + L + +QE E+ K LE + E L E L R K
Sbjct: 292 KTNPSRIRIALGNEASTVQEEEQDRKGSHTDLES------INENLVESALRRVNREEKGN 345
Query: 356 SLLKERKFLSLASNPEL 372
+ RK AS+P L
Sbjct: 346 KSVHLRK----ASSPNL 358
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 203 bits (517), Expect = 2e-52
Identities = 133/377 (35%), Positives = 191/377 (50%), Gaps = 30/377 (7%)
Query: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
+DY VL IG GS+GR ++ +S ++ KE+ + + Q E LL ++KHP
Sbjct: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHP 60
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
NIV + + LYIVMEYC+GGDL I + ++ + E+ +L TQ+ L +
Sbjct: 61 NIVAFKESF--EAEGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVN 116
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
H++ VLHRD+K N+FL VKLGDFG AR+L++ +FA T+VGTPYY+ P
Sbjct: 117 HIHKKR-----VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPP 171
Query: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
E + YN KSDIWSLGC+LYELC L PF A S K L K+ +G +P YS EL
Sbjct: 172 EIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQ 231
Query: 246 EIITRMLNLKDYHRPSVEEILENPLIA---------DLVADEQRRNLER-RGRQLGEPEK 295
++ +M HRPS +L ++A +++ + LE + + P K
Sbjct: 232 FLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRK 291
Query: 296 SQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNY 355
+ S + L + +QE E+ K LE + E L E L R K
Sbjct: 292 KTNPSRIRIALGNEASTVQEEEQDRKGSHTDLES------INENLVESALRRVNREEKGN 345
Query: 356 SLLKERKFLSLASNPEL 372
+ RK AS+P L
Sbjct: 346 KSVHLRK----ASSPNL 358
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 201 bits (512), Expect = 8e-52
Identities = 133/370 (35%), Positives = 189/370 (51%), Gaps = 33/370 (8%)
Query: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
+DY VL IG GS+GR ++ +S ++ KE+ + + Q E LL ++KHP
Sbjct: 2 DDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHP 60
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
NIV + + LYIVMEYC+GGDL I + ++ + E+ +L TQ+ L +
Sbjct: 61 NIVAFKESF--EAEGHLYIVMEYCDGGDLMQKIKQ--QKGKLFPEDMILNWFTQMCLGVN 116
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
H++ VLHRD+K N+FL VKLGDFG AR+L++ +FA T+VGTPYY+ P
Sbjct: 117 HIHKKR-----VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPP 171
Query: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
E + YN KSDIWSLGC+LYELC L PF A S K L K+ +G +P YS EL
Sbjct: 172 EIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQ 231
Query: 246 EIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSE 305
++ +M HRPS +L ++A LV ++ PE + E
Sbjct: 232 FLVKQMFKRNPSHRPSATTLLSRGIVARLV------------QKCLPPEIIME----YGE 275
Query: 306 LKLKEIQLQERERALKAREERLEQKEQEL---CVRERLAEDKLARAENLLKNYSLLKERK 362
L+EI+ + K +EE ++K + E L E L R K + RK
Sbjct: 276 EVLEEIKNSKHNTPRKKQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRK 335
Query: 363 FLSLASNPEL 372
AS+P L
Sbjct: 336 ----ASSPNL 341
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 192 bits (489), Expect = 4e-49
Identities = 108/264 (40%), Positives = 149/264 (56%), Gaps = 8/264 (3%)
Query: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI 67
Y L +G GSYG ++ + DGK V K+L+ + + E++ E LL +LKHPNI
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 68 VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKEC 127
V Y + + + LYIVM +CEGGDL + + ++ Q L E V+ Q+ +AL+
Sbjct: 66 VTYKESW-EGGDGLLYIVMGFCEGGDLYRKLKE--QKGQLLPENQVVEWFVQIAMALQYL 122
Query: 128 HRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQ 187
H + +LHRDLK NVFL +K+GD G+AR+L + A T +GTPYYMSPE
Sbjct: 123 HEKH-----ILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPEL 177
Query: 188 MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEI 247
+ YN KSD+W+LGC +YE+ L F A L +I EGK +P YS EL E+
Sbjct: 178 FSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAEL 237
Query: 248 ITRMLNLKDYHRPSVEEILENPLI 271
I ML+ + RPSV IL P I
Sbjct: 238 IRTMLSKRPEERPSVRSILRQPYI 261
Score = 31.2 bits (69), Expect = 2.0
Identities = 36/158 (22%), Positives = 69/158 (43%), Gaps = 13/158 (8%)
Query: 268 NPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERL 327
+P++ + ++ E + R + S SS +S K + + +ER R +++EE
Sbjct: 571 HPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSE-MSSSKDRPLSARERRRLKQSQEEMS 629
Query: 328 EQ----KEQELCVR---ERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVI 380
++ L V + ED+ A L + S+ +ERK + S EL + SS
Sbjct: 630 SSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTD 689
Query: 381 KKKVHF-SGESKEN----IMRSENSESQLTSKSKCKDL 413
K + G+ + N +++ +L SK C+D+
Sbjct: 690 KSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDV 727
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 189 bits (481), Expect = 3e-48
Identities = 109/297 (36%), Positives = 170/297 (57%), Gaps = 16/297 (5%)
Query: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI 67
Y + +G G++G RR D ++VWKE+D ++E E++ ++E+ +L L+H NI
Sbjct: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Query: 68 VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKEC 127
+ YY+ +D NTTL I +EYC GG+L I + ++ + +EE V+ + Q+ A+
Sbjct: 112 IAYYNHFMD--NTTLLIELEYCNGGNLYDKILR--QKDKLFEEEMVVWYLFQIVSAVSCI 167
Query: 128 HRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQ 187
H+ +LHRD+K N+FL +KLGD+GLA+ LN + S A+T VGTPYYMSPE
Sbjct: 168 HKAG-----ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPEL 222
Query: 188 MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREG--KFRRIPYRYSDELN 245
+ YN KSDIW++GC+++EL L F A + L KI +G +YS EL
Sbjct: 223 CQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELI 282
Query: 246 EIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPV 302
+++ L+ RP+ +E+L+ PL+ ++RR +E + L P K SS V
Sbjct: 283 QMVHSCLDQDPEQRPTADELLDRPLLR-----KRRREMEEKVTLLNAPTKRPRSSTV 334
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 188 bits (478), Expect = 7e-48
Identities = 107/266 (40%), Positives = 154/266 (57%), Gaps = 11/266 (4%)
Query: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
E YE + +G G++G RK+D K+++ K++ MT+ E+Q +E +L+ L HP
Sbjct: 2 EKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHP 61
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
N++ YY+ ++ + L I MEY GG LA I K + L+EE +L Q+ LAL
Sbjct: 62 NVIEYYENFLE--DKALMIAMEYAPGGTLAEFIQK--RCNSLLEEETILHFFVQILLALH 117
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDG-KQNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184
H H +LHRDLK N+ LD + VK+GDFG+++IL+ S A T VGTP Y+S
Sbjct: 118 HVHT-----HLILHRDLKTQNILLDKHRMVVKIGDFGISKILS-SKSKAYTVVGTPCYIS 171
Query: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244
PE YN+KSDIW+LGC+LYEL +L F A + L KI G F I RYS EL
Sbjct: 172 PELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPEL 231
Query: 245 NEIITRMLNLKDYHRPSVEEILENPL 270
+++ +L+L+ RP + I+ PL
Sbjct: 232 RQLVLSLLSLEPAQRPPLSHIMAQPL 257
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 181 bits (460), Expect = 9e-46
Identities = 134/419 (31%), Positives = 203/419 (48%), Gaps = 36/419 (8%)
Query: 5 AEDYEVLYTIGTGSYGRCQKI---RRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRE 61
A Y + +G+GS+G + + K ++ V KE+ G + E E LL +
Sbjct: 26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSK 85
Query: 62 LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121
L HP IV+++ +++ N I+ EYCEG DL I + + + E ++ QL
Sbjct: 86 LDHPAIVKFHASFVEQDN--FCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLL 143
Query: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSFAKTFVGTP 180
L + H R +LHRDLK NVFL K N+ K+GDFG++R+L A T GTP
Sbjct: 144 LGVDYMHERR-----ILHRDLKSKNVFL--KNNLLKIGDFGVSRLLMGSCDLATTLTGTP 196
Query: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY 240
+YMSPE + Y+ KSDIWSL C+LYE+C + F + + KI EG +P RY
Sbjct: 197 HYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERY 256
Query: 241 SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS 300
ELN I+ MLN RPS EIL+ P + DEQ +NL R ++ +K+ D
Sbjct: 257 PKELNAIMESMLNKNPSLRPSAIEILKIPYL-----DEQLQNLMCRYSEMTLEDKNLDCQ 311
Query: 301 PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE 360
+ + + +Q + + L+A E Q++ RER+ KL A+ + + E
Sbjct: 312 KEAAHI-INAMQKRIHLQTLRALSE-----VQKMTPRERMRLRKLQAADEKARKLKKIVE 365
Query: 361 RKFLSLASNPELL------NLPSSVIKKKVHFSG-ESKENIMRSENSESQLTSKSKCKD 412
K+ + + L L V+ +K H G E KE E E +L+ + +D
Sbjct: 366 EKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKE-----EQPEGRLSCSPQDED 419
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 181 bits (460), Expect = 9e-46
Identities = 134/419 (31%), Positives = 203/419 (48%), Gaps = 36/419 (8%)
Query: 5 AEDYEVLYTIGTGSYGRCQKI---RRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRE 61
A Y + +G+GS+G + + K ++ V KE+ G + E E LL +
Sbjct: 26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSK 85
Query: 62 LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121
L HP IV+++ +++ N I+ EYCEG DL I + + + E ++ QL
Sbjct: 86 LDHPAIVKFHASFVEQDN--FCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLL 143
Query: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSFAKTFVGTP 180
L + H R +LHRDLK NVFL K N+ K+GDFG++R+L A T GTP
Sbjct: 144 LGVDYMHERR-----ILHRDLKSKNVFL--KNNLLKIGDFGVSRLLMGSCDLATTLTGTP 196
Query: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY 240
+YMSPE + Y+ KSDIWSL C+LYE+C + F + + KI EG +P RY
Sbjct: 197 HYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERY 256
Query: 241 SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS 300
ELN I+ MLN RPS EIL+ P + DEQ +NL R ++ +K+ D
Sbjct: 257 PKELNAIMESMLNKNPSLRPSAIEILKIPYL-----DEQLQNLMCRYSEMTLEDKNLDCQ 311
Query: 301 PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE 360
+ + + +Q + + L+A E Q++ RER+ KL A+ + + E
Sbjct: 312 KEAAHI-INAMQKRIHLQTLRALSE-----VQKMTPRERMRLRKLQAADEKARKLKKIVE 365
Query: 361 RKFLSLASNPELL------NLPSSVIKKKVHFSG-ESKENIMRSENSESQLTSKSKCKD 412
K+ + + L L V+ +K H G E KE E E +L+ + +D
Sbjct: 366 EKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKE-----EQPEGRLSCSPQDED 419
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 181 bits (460), Expect = 9e-46
Identities = 134/419 (31%), Positives = 203/419 (48%), Gaps = 36/419 (8%)
Query: 5 AEDYEVLYTIGTGSYGRCQKI---RRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRE 61
A Y + +G+GS+G + + K ++ V KE+ G + E E LL +
Sbjct: 26 ARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSK 85
Query: 62 LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121
L HP IV+++ +++ N I+ EYCEG DL I + + + E ++ QL
Sbjct: 86 LDHPAIVKFHASFVEQDN--FCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLL 143
Query: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSFAKTFVGTP 180
L + H R +LHRDLK NVFL K N+ K+GDFG++R+L A T GTP
Sbjct: 144 LGVDYMHERR-----ILHRDLKSKNVFL--KNNLLKIGDFGVSRLLMGSCDLATTLTGTP 196
Query: 181 YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY 240
+YMSPE + Y+ KSDIWSL C+LYE+C + F + + KI EG +P RY
Sbjct: 197 HYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERY 256
Query: 241 SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS 300
ELN I+ MLN RPS EIL+ P + DEQ +NL R ++ +K+ D
Sbjct: 257 PKELNAIMESMLNKNPSLRPSAIEILKIPYL-----DEQLQNLMCRYSEMTLEDKNLDCQ 311
Query: 301 PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE 360
+ + + +Q + + L+A E Q++ RER+ KL A+ + + E
Sbjct: 312 KEAAHI-INAMQKRIHLQTLRALSE-----VQKMTPRERMRLRKLQAADEKARKLKKIVE 365
Query: 361 RKFLSLASNPELL------NLPSSVIKKKVHFSG-ESKENIMRSENSESQLTSKSKCKD 412
K+ + + L L V+ +K H G E KE E E +L+ + +D
Sbjct: 366 EKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKE-----EQPEGRLSCSPQDED 419
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 173 bits (439), Expect = 2e-43
Identities = 98/260 (37%), Positives = 148/260 (56%), Gaps = 11/260 (4%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAE-KQMLVSEVNLLRELKHP 65
D+++ IG G + K D K + K++ M +A+ +Q V E+ LL++L HP
Sbjct: 78 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 137
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
NI++Y D I+ + L IV+E + GDL+ +I K+++ + E V + QL A++
Sbjct: 138 NIIKYLDSFIE--DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVE 195
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
H R V+HRD+KPANVF+ VKLGD GL R + +T+ A + VGTPYYMSP
Sbjct: 196 HMHSRR-----VMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSP 250
Query: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQK--ELAGKIREGKFRRIP-YRYSD 242
E+++ YN KSDIWSLGCLLYE+ AL PF L KI + + +P YS+
Sbjct: 251 ERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSE 310
Query: 243 ELNEIITRMLNLKDYHRPSV 262
+L E+++ + + RP +
Sbjct: 311 KLRELVSMCICPDPHQRPDI 330
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 173 bits (439), Expect = 2e-43
Identities = 98/260 (37%), Positives = 148/260 (56%), Gaps = 11/260 (4%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAE-KQMLVSEVNLLRELKHP 65
D+++ IG G + K D K + K++ M +A+ +Q V E+ LL++L HP
Sbjct: 44 DFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHP 103
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
NI++Y D I+ + L IV+E + GDL+ +I K+++ + E V + QL A++
Sbjct: 104 NIIKYLDSFIE--DNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVE 161
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
H R V+HRD+KPANVF+ VKLGD GL R + +T+ A + VGTPYYMSP
Sbjct: 162 HMHSRR-----VMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSP 216
Query: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQK--ELAGKIREGKFRRIP-YRYSD 242
E+++ YN KSDIWSLGCLLYE+ AL PF L KI + + +P YS+
Sbjct: 217 ERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSE 276
Query: 243 ELNEIITRMLNLKDYHRPSV 262
+L E+++ + + RP +
Sbjct: 277 KLRELVSMCICPDPHQRPDI 296
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 168 bits (425), Expect = 1e-41
Identities = 95/265 (35%), Positives = 148/265 (55%), Gaps = 11/265 (4%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQM-LVSEVNLLRELKHP 65
++ + IG G + + DG + K++ + +A+ + + E++LL++L HP
Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
N+++YY I+ + L IV+E + GDL+ +I K+++ + E V + QL AL+
Sbjct: 93 NVIKYYASFIE--DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
H R V+HRD+KPANVF+ VKLGD GL R + T+ A + VGTPYYMSP
Sbjct: 151 HMHSRR-----VMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSP 205
Query: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPF--TAFSQKELAGKIREGKFRRIPY-RYSD 242
E+++ YN KSDIWSLGCLLYE+ AL PF + L KI + + +P YS+
Sbjct: 206 ERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSE 265
Query: 243 ELNEIITRMLNLKDYHRPSVEEILE 267
EL +++ +N RP V + +
Sbjct: 266 ELRQLVNMCINPDPEKRPDVTYVYD 290
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 145 bits (365), Expect = 9e-35
Identities = 105/302 (34%), Positives = 147/302 (48%), Gaps = 18/302 (5%)
Query: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
E Y VL IG GS+GR K RRK +++ K + +E E + L E+ ++R L+HP
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHP 61
Query: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
NIV D T+ + +V +Y EG +L ++ K L E+ V + QL AL
Sbjct: 62 NIVHMLDSF--ETDKEVVVVTDYAEG-ELFQILEDDGK----LPEDQVQAIAAQLVSALY 114
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
H H +LHRD+KP N+ L +KL DFG AR ++ +T + GTP YMSP
Sbjct: 115 YLH-----SHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSP 169
Query: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
E + Y+ +D+WS+GC+LYEL PPF A S +L I + R P S
Sbjct: 170 ELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPV-RWPSTISPCFK 228
Query: 246 EIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSE 305
+ +L R S ++L +P IA V E G LG P S+ P L
Sbjct: 229 NFLQGLLTKDPRQRLSWPDLLYHPFIAGHVT----IITEPAGPDLGTPFTSR-LPPELQV 283
Query: 306 LK 307
LK
Sbjct: 284 LK 285
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 136 bits (343), Expect = 3e-32
Identities = 82/263 (31%), Positives = 138/263 (52%), Gaps = 14/263 (5%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R GK + K +D + + Q L EV +++ L HPN
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 111
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126
IV+ ++ I T TLY+VMEY GG++ + + + E+ Q+ A++
Sbjct: 112 IVKLFEVI--ETEKTLYLVMEYASGGEVFDYLVAHGR----MKEKEARAKFRQIVSAVQY 165
Query: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPE 186
CH++ ++HRDLK N+ LD N+K+ DFG + TF G+P Y +PE
Sbjct: 166 CHQK-----FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKL-DTFCGSPPYAAPE 219
Query: 187 QMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S +
Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCE 278
Query: 246 EIITRMLNLKDYHRPSVEEILEN 268
++ + L L R ++E+I+++
Sbjct: 279 NLLKKFLILNPSKRGTLEQIMKD 301
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 136 bits (343), Expect = 3e-32
Identities = 82/263 (31%), Positives = 138/263 (52%), Gaps = 14/263 (5%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R GK + K +D + + Q L EV +++ L HPN
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 111
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126
IV+ ++ I T TLY+VMEY GG++ + + + E+ Q+ A++
Sbjct: 112 IVKLFEVI--ETEKTLYLVMEYASGGEVFDYLVAHGR----MKEKEARAKFRQIVSAVQY 165
Query: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPE 186
CH++ ++HRDLK N+ LD N+K+ DFG + TF G+P Y +PE
Sbjct: 166 CHQK-----FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKL-DTFCGSPPYAAPE 219
Query: 187 QMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S +
Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCE 278
Query: 246 EIITRMLNLKDYHRPSVEEILEN 268
++ + L L R ++E+I+++
Sbjct: 279 NLLKKFLILNPSKRGTLEQIMKD 301
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 136 bits (343), Expect = 3e-32
Identities = 82/263 (31%), Positives = 138/263 (52%), Gaps = 14/263 (5%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R GK + K +D + + Q L EV +++ L HPN
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 111
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126
IV+ ++ I T TLY+VMEY GG++ + + + E+ Q+ A++
Sbjct: 112 IVKLFEVI--ETEKTLYLVMEYASGGEVFDYLVAHGR----MKEKEARAKFRQIVSAVQY 165
Query: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPE 186
CH++ ++HRDLK N+ LD N+K+ DFG + TF G+P Y +PE
Sbjct: 166 CHQK-----FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKL-DTFCGSPPYAAPE 219
Query: 187 QMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S +
Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCE 278
Query: 246 EIITRMLNLKDYHRPSVEEILEN 268
++ + L L R ++E+I+++
Sbjct: 279 NLLKKFLILNPSKRGTLEQIMKD 301
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 136 bits (343), Expect = 3e-32
Identities = 82/263 (31%), Positives = 138/263 (52%), Gaps = 14/263 (5%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R GK + K +D + + Q L EV +++ L HPN
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 111
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126
IV+ ++ I T TLY+VMEY GG++ + + + E+ Q+ A++
Sbjct: 112 IVKLFEVI--ETEKTLYLVMEYASGGEVFDYLVAHGR----MKEKEARAKFRQIVSAVQY 165
Query: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPE 186
CH++ ++HRDLK N+ LD N+K+ DFG + TF G+P Y +PE
Sbjct: 166 CHQK-----FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKL-DTFCGSPPYAAPE 219
Query: 187 QMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S +
Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCE 278
Query: 246 EIITRMLNLKDYHRPSVEEILEN 268
++ + L L R ++E+I+++
Sbjct: 279 NLLKKFLILNPSKRGTLEQIMKD 301
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 136 bits (343), Expect = 3e-32
Identities = 82/263 (31%), Positives = 138/263 (52%), Gaps = 14/263 (5%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R GK + K +D + + Q L EV +++ L HPN
Sbjct: 19 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 78
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126
IV+ ++ I T TLY+VMEY GG++ + + + E+ Q+ A++
Sbjct: 79 IVKLFEVI--ETEKTLYLVMEYASGGEVFDYLVAHGR----MKEKEARAKFRQIVSAVQY 132
Query: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPE 186
CH++ ++HRDLK N+ LD N+K+ DFG + TF G+P Y +PE
Sbjct: 133 CHQK-----FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKL-DTFCGSPPYAAPE 186
Query: 187 QMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S +
Sbjct: 187 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCE 245
Query: 246 EIITRMLNLKDYHRPSVEEILEN 268
++ + L L R ++E+I+++
Sbjct: 246 NLLKKFLILNPSKRGTLEQIMKD 268
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 136 bits (343), Expect = 3e-32
Identities = 86/268 (32%), Positives = 143/268 (53%), Gaps = 18/268 (6%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R G+ + K +D + + Q L EV +++ L HPN
Sbjct: 58 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 117
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126
IV+ ++ I T TLY+VMEY G++ + + + E+ Q+ A+
Sbjct: 118 IVKLFEVI--ETEKTLYLVMEYASAGEVFDYLVSHGR----MKEKEARAKFRQIVSAVHY 171
Query: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAK--TFVGTPYYMS 184
CH+++ ++HRDLK N+ LD + N+K+ DFG + N T +K TF G+P Y +
Sbjct: 172 CHQKN-----IVHRDLKAENLLLDAEANIKIADFGFS---NEFTLGSKLDTFCGSPPYAA 223
Query: 185 PEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDE 243
PE Y+ + DIWSLG +LY L + PF + KEL ++ GK+ R+P+ S +
Sbjct: 224 PELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY-RVPFYMSTD 282
Query: 244 LNEIITRMLNLKDYHRPSVEEILENPLI 271
I+ R L L R ++E+I+++ I
Sbjct: 283 CESILRRFLVLNPAKRCTLEQIMKDKWI 310
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 136 bits (342), Expect = 4e-32
Identities = 82/263 (31%), Positives = 138/263 (52%), Gaps = 14/263 (5%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y + TIG G++ + + R G+ + K +D + Q L EV +++ L HPN
Sbjct: 59 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 118
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKE 126
IV+ ++ I T TLY+VMEY GG++ + + + E+ Q+ A++
Sbjct: 119 IVKLFEVI--ETEKTLYLVMEYASGGEVFDYLVAHGR----MKEKEARAKFRQIVSAVQY 172
Query: 127 CHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPE 186
CH++ ++HRDLK N+ LDG N+K+ DFG + TF G+P Y +PE
Sbjct: 173 CHQK-----YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKL-DTFCGSPPYAAPE 226
Query: 187 QMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN 245
Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S +
Sbjct: 227 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCE 285
Query: 246 EIITRMLNLKDYHRPSVEEILEN 268
++ ++L L R S+E+I+++
Sbjct: 286 NLLKKLLVLNPIKRGSLEQIMKD 308
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 135 bits (341), Expect = 6e-32
Identities = 85/266 (31%), Positives = 142/266 (53%), Gaps = 20/266 (7%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R G+ + K +D + Q L EV +++ L HPN
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 114
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLAS-VITKGTKERQYLDEEFVLRVMTQLTLALK 125
IV+ ++ I T TLY++MEY GG++ ++ G + + +F Q+ A++
Sbjct: 115 IVKLFEVI--ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKF-----RQIVSAVQ 167
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAK--TFVGTPYYM 183
CH++ ++HRDLK N+ LD N+K+ DFG + N T K TF G+P Y
Sbjct: 168 YCHQK-----RIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYA 219
Query: 184 SPEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSD 242
+PE Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMST 278
Query: 243 ELNEIITRMLNLKDYHRPSVEEILEN 268
+ ++ R L L R ++E+I+++
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMKD 304
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 135 bits (341), Expect = 6e-32
Identities = 85/266 (31%), Positives = 142/266 (53%), Gaps = 20/266 (7%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R G+ + K +D + Q L EV +++ L HPN
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 114
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLAS-VITKGTKERQYLDEEFVLRVMTQLTLALK 125
IV+ ++ I T TLY++MEY GG++ ++ G + + +F Q+ A++
Sbjct: 115 IVKLFEVI--ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKF-----RQIVSAVQ 167
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAK--TFVGTPYYM 183
CH++ ++HRDLK N+ LD N+K+ DFG + N T K TF G+P Y
Sbjct: 168 YCHQK-----RIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYA 219
Query: 184 SPEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSD 242
+PE Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMST 278
Query: 243 ELNEIITRMLNLKDYHRPSVEEILEN 268
+ ++ R L L R ++E+I+++
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMKD 304
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 135 bits (341), Expect = 6e-32
Identities = 85/266 (31%), Positives = 142/266 (53%), Gaps = 20/266 (7%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R G+ + K +D + Q L EV +++ L HPN
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 114
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLAS-VITKGTKERQYLDEEFVLRVMTQLTLALK 125
IV+ ++ I T TLY++MEY GG++ ++ G + + +F Q+ A++
Sbjct: 115 IVKLFEVI--ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKF-----RQIVSAVQ 167
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAK--TFVGTPYYM 183
CH++ ++HRDLK N+ LD N+K+ DFG + N T K TF G+P Y
Sbjct: 168 YCHQK-----RIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYA 219
Query: 184 SPEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSD 242
+PE Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMST 278
Query: 243 ELNEIITRMLNLKDYHRPSVEEILEN 268
+ ++ R L L R ++E+I+++
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMKD 304
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 135 bits (341), Expect = 6e-32
Identities = 85/266 (31%), Positives = 142/266 (53%), Gaps = 20/266 (7%)
Query: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
+Y +L TIG G++ + + R G+ + K +D + Q L EV +++ L HPN
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 114
Query: 67 IVRYYDRIIDRTNTTLYIVMEYCEGGDLAS-VITKGTKERQYLDEEFVLRVMTQLTLALK 125
IV+ ++ I T TLY++MEY GG++ ++ G + + +F Q+ A++
Sbjct: 115 IVKLFEVI--ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKF-----RQIVSAVQ 167
Query: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAK--TFVGTPYYM 183
CH++ ++HRDLK N+ LD N+K+ DFG + N T K TF G+P Y
Sbjct: 168 YCHQK-----RIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYA 219
Query: 184 SPEQMNRMSYN-EKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSD 242
+PE Y+ + D+WSLG +LY L + PF + KEL ++ GK+ RIP+ S
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-RIPFYMST 278
Query: 243 ELNEIITRMLNLKDYHRPSVEEILEN 268
+ ++ R L L R ++E+I+++
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMKD 304
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 135 bits (339), Expect = 1e-31
Identities = 109/395 (27%), Positives = 184/395 (46%), Gaps = 50/395 (12%)
Query: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP-N 66
+E++ +G G+YG+ K R G++ K +D +T E++ + E+N+L++ H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD---VTGDEEEEIKQEINMLKKYSHHRN 81
Query: 67 IVRYYDRIIDRT----NTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122
I YY I + + L++VME+C G + +I K TK L EE++ + ++
Sbjct: 82 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLI-KNTKGNT-LKEEWIAYICREILR 139
Query: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYY 182
L H+ H V+HRD+K NV L VKL DFG++ L+ TF+GTPY+
Sbjct: 140 GLSHLHQ-----HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 194
Query: 183 MSPE-----QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRI- 236
M+PE + +Y+ KSD+WSLG E+ PP I R+
Sbjct: 195 MAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLK 254
Query: 237 PYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRR-----NLERRGRQLG 291
++S + I L RP+ E+++++P I D + Q R +++R ++ G
Sbjct: 255 SKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 292 -------------EPEKSQDSSPVLSELKLK----------EIQLQERERALKAREERLE 328
E E+ DS S L L +QL +ER+ R ++LE
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 329 QKEQELCVRER-LAEDKLARAENLLKNYSLLKERK 362
Q+++E +R L ++ R E + L+E++
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQ 409
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 135 bits (339), Expect = 1e-31
Identities = 109/395 (27%), Positives = 184/395 (46%), Gaps = 50/395 (12%)
Query: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP-N 66
+E++ +G G+YG+ K R G++ K +D +T E++ + E+N+L++ H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD---VTGDEEEEIKQEINMLKKYSHHRN 81
Query: 67 IVRYYDRIIDRT----NTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122
I YY I + + L++VME+C G + +I K TK L EE++ + ++
Sbjct: 82 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLI-KNTKGNT-LKEEWIAYICREILR 139
Query: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYY 182
L H+ H V+HRD+K NV L VKL DFG++ L+ TF+GTPY+
Sbjct: 140 GLSHLHQ-----HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 194
Query: 183 MSPE-----QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRI- 236
M+PE + +Y+ KSD+WSLG E+ PP I R+
Sbjct: 195 MAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLK 254
Query: 237 PYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRR-----NLERRGRQLG 291
++S + I L RP+ E+++++P I D + Q R +++R ++ G
Sbjct: 255 SKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 292 -------------EPEKSQDSSPVLSELKLK----------EIQLQERERALKAREERLE 328
E E+ DS S L L +QL +ER+ R ++LE
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 329 QKEQELCVRER-LAEDKLARAENLLKNYSLLKERK 362
Q+++E +R L ++ R E + L+E++
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQ 409
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 135 bits (339), Expect = 1e-31
Identities = 109/395 (27%), Positives = 184/395 (46%), Gaps = 50/395 (12%)
Query: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP-N 66
+E++ +G G+YG+ K R G++ K +D +T E++ + E+N+L++ H N
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD---VTGDEEEEIKQEINMLKKYSHHRN 81
Query: 67 IVRYYDRIIDRT----NTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122
I YY I + + L++VME+C G + +I K TK L EE++ + ++
Sbjct: 82 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLI-KNTKGNT-LKEEWIAYICREILR 139
Query: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYY 182
L H+ H V+HRD+K NV L VKL DFG++ L+ TF+GTPY+
Sbjct: 140 GLSHLHQ-----HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 194
Query: 183 MSPE-----QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRI- 236
M+PE + +Y+ KSD+WSLG E+ PP I R+
Sbjct: 195 MAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLK 254
Query: 237 PYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRR-----NLERRGRQLG 291
++S + I L RP+ E+++++P I D + Q R +++R ++ G
Sbjct: 255 SKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
Query: 292 -------------EPEKSQDSSPVLSELKLK----------EIQLQERERALKAREERLE 328
E E+ DS S L L +QL +ER+ R ++LE
Sbjct: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLE 374
Query: 329 QKEQELCVRER-LAEDKLARAENLLKNYSLLKERK 362
Q+++E +R L ++ R E + L+E++
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQ 409
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,945,377
Number of Sequences: 37866
Number of extensions: 705054
Number of successful extensions: 8641
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 751
Number of HSP's successfully gapped in prelim test: 575
Number of HSP's that attempted gapping in prelim test: 4026
Number of HSP's gapped (non-prelim): 2869
length of query: 445
length of database: 18,247,518
effective HSP length: 105
effective length of query: 340
effective length of database: 14,271,588
effective search space: 4852339920
effective search space used: 4852339920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.