BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor [Homo sapiens] (915 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 1858 0.0 gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 1828 0.0 gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 1390 0.0 gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 1379 0.0 gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 1316 0.0 gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 1218 0.0 gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 732 0.0 gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 720 0.0 gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 644 0.0 gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 644 0.0 gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 642 0.0 gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 642 0.0 gi|37577159 calcium-sensing receptor [Homo sapiens] 401 e-111 gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 241 2e-63 gi|112807234 G protein-coupled receptor, family C, group 6, memb... 230 4e-60 gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 209 1e-53 gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ... 207 5e-53 gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 202 9e-52 gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 116 8e-26 gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 105 1e-22 gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 65 3e-10 gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 55 2e-07 gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 55 2e-07 gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 55 2e-07 gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] 49 2e-05 gi|7706451 G protein-coupled receptor, family C, group 5, member... 45 4e-04 gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 40 0.010 gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 40 0.010 gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 40 0.010 gi|93352554 GPR158-like 1 [Homo sapiens] 40 0.010 >gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor [Homo sapiens] Length = 915 Score = 1858 bits (4813), Expect = 0.0 Identities = 915/915 (100%), Positives = 915/915 (100%) Query: 1 MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK 60 MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK Sbjct: 1 MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK 60 Query: 61 GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL 120 GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL Sbjct: 61 GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL 120 Query: 121 TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA 180 TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA Sbjct: 121 TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA 180 Query: 181 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ 240 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ Sbjct: 181 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ 240 Query: 241 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK 300 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK Sbjct: 241 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK 300 Query: 301 RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR 360 RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR Sbjct: 301 RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR 360 Query: 361 NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH 420 NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH Sbjct: 361 NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH 420 Query: 421 ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF 480 ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF Sbjct: 421 ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF 480 Query: 481 QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP 540 QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP Sbjct: 481 QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP 540 Query: 541 CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML 600 CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML Sbjct: 541 CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML 600 Query: 601 GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV 660 GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV Sbjct: 601 GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV 660 Query: 661 FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW 720 FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW Sbjct: 661 FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW 720 Query: 721 FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV 780 FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV Sbjct: 721 FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV 780 Query: 781 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML 840 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML Sbjct: 781 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML 840 Query: 841 YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS 900 YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS Sbjct: 841 YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS 900 Query: 901 PAAKKKYVSYNNLVI 915 PAAKKKYVSYNNLVI Sbjct: 901 PAAKKKYVSYNNLVI 915 >gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor [Homo sapiens] Length = 922 Score = 1828 bits (4734), Expect = 0.0 Identities = 899/900 (99%), Positives = 900/900 (100%) Query: 1 MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK 60 MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK Sbjct: 1 MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK 60 Query: 61 GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL 120 GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL Sbjct: 61 GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL 120 Query: 121 TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA 180 TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA Sbjct: 121 TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA 180 Query: 181 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ 240 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ Sbjct: 181 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ 240 Query: 241 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK 300 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK Sbjct: 241 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK 300 Query: 301 RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR 360 RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR Sbjct: 301 RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR 360 Query: 361 NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH 420 NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH Sbjct: 361 NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH 420 Query: 421 ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF 480 ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF Sbjct: 421 ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF 480 Query: 481 QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP 540 QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP Sbjct: 481 QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP 540 Query: 541 CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML 600 CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML Sbjct: 541 CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML 600 Query: 601 GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV 660 GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV Sbjct: 601 GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV 660 Query: 661 FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW 720 FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW Sbjct: 661 FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW 720 Query: 721 FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV 780 FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV Sbjct: 721 FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV 780 Query: 781 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML 840 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML Sbjct: 781 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML 840 Query: 841 YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS 900 YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPN+ Sbjct: 841 YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNN 900 >gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor [Homo sapiens] Length = 908 Score = 1390 bits (3597), Expect = 0.0 Identities = 666/872 (76%), Positives = 767/872 (87%), Gaps = 4/872 (0%) Query: 41 HSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVT 100 HSIR++GD+ LGGLFPVHAKG GVPCG++K+E GIHRLEAMLYA+DQIN DP+LL N+T Sbjct: 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNIT 97 Query: 101 LGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSS 160 LG RILDTCSRDTYALEQSLTFVQALI+KD SDV+C NG+PP+F KP+K+ GVIGA+ SS Sbjct: 98 LGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS 157 Query: 161 VSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNY 220 VSIMVANILRLF+IPQISYASTAPELSD+ RYDFFSRVVPPDS+QAQAMVDIV ALGWNY Sbjct: 158 VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNY 217 Query: 221 VSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNS 280 VSTLASEG+YGE GVE+FTQIS+E GG+CIAQS +IP+E R +F++IIK+LL+TPN+ Sbjct: 218 VSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNA 275 Query: 281 RAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKR 340 RAV++FAN++DI++IL AAK+ +Q GHFLW+GSDSWGSKI P++Q E+IAEGA+TI PKR Sbjct: 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKR 335 Query: 341 ATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDS 400 A+++GFD YF SRTL NNRRNVWFAE+WEENF CKL G K+ +KCTG ERI +DS Sbjct: 336 ASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHG-KRNSHIKKCTGLERIARDS 394 Query: 401 NYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGS 460 +YEQEGKVQFVIDAVY+MA+ALH+M+KDLC Y G+CP M GK+LL YIR VNFNGS Sbjct: 395 SYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGS 454 Query: 461 AGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPA 520 AGTPV FN+NGDAPGRYDIFQYQ TN S Y++IG WT++L L +EDMQW PA Sbjct: 455 AGTPVTFNENGDAPGRYDIFQYQITNKSTE-YKVIGHWTNQLHLKVEDMQWAHREHTHPA 513 Query: 521 SVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIP 580 SVC+LPCKPG+RKKT KG PCCW CE C+GY YQ DE++C+ CP DQRPN NRTGCQ IP Sbjct: 514 SVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIP 573 Query: 581 IIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCY 640 IIKLEWHSPWAV+PVF+A+LGIIAT FV+ TF+RYNDTPIVRASGRELSYVLLTGIFLCY Sbjct: 574 IIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCY 633 Query: 641 IITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPT 700 ITFLMIA PD +CSFRRVFLGLGMC SYAALLTKTNRI+RIFEQGKKSVTAP+ ISP Sbjct: 634 SITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPA 693 Query: 701 SQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSL 760 SQL IT SLISVQLLGVF+WF VDPP+IIIDY E +T++PE+ARGVLKCDI+DL +ICSL Sbjct: 694 SQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSL 753 Query: 761 GYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYI 820 GYSILLMVTCTVYAIKTRGVPE FNEAKPIGFTMYTTCI+WLAFIPIFFGTAQSAEK+YI Sbjct: 754 GYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813 Query: 821 QTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKP 880 QTTTLT+SM+LSASV+LGMLYMPKVYIIIFHPE NVQKRKRSFKAVVTAATM S+L K Sbjct: 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKG 873 Query: 881 SDRPNGEAKTELCENVDPNSPAAKKKYVSYNN 912 +DRPNGE K+ELCE+++ N+ + K Y+SY+N Sbjct: 874 NDRPNGEVKSELCESLETNTSSTKTTYISYSN 905 >gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor [Homo sapiens] Length = 908 Score = 1379 bits (3570), Expect = 0.0 Identities = 662/863 (76%), Positives = 761/863 (88%), Gaps = 4/863 (0%) Query: 41 HSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVT 100 HSIR++GD+ LGGLFPVHAKG GVPCG++K+E GIHRLEAMLYA+DQIN DP+LL N+T Sbjct: 38 HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNIT 97 Query: 101 LGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSS 160 LG RILDTCSRDTYALEQSLTFVQALI+KD SDV+C NG+PP+F KP+K+ GVIGA+ SS Sbjct: 98 LGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS 157 Query: 161 VSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNY 220 VSIMVANILRLF+IPQISYASTAPELSD+ RYDFFSRVVPPDS+QAQAMVDIV ALGWNY Sbjct: 158 VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNY 217 Query: 221 VSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNS 280 VSTLASEG+YGE GVE+FTQIS+E GG+CIAQS +IP+E R +F++IIK+LL+TPN+ Sbjct: 218 VSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNA 275 Query: 281 RAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKR 340 RAV++FAN++DI++IL AAK+ +Q GHFLW+GSDSWGSKI P++Q E+IAEGA+TI PKR Sbjct: 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKR 335 Query: 341 ATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDS 400 A+++GFD YF SRTL NNRRNVWFAE+WEENF CKL G K+ +KCTG ERI +DS Sbjct: 336 ASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHG-KRNSHIKKCTGLERIARDS 394 Query: 401 NYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGS 460 +YEQEGKVQFVIDAVY+MA+ALH+M+KDLC Y G+CP M GK+LL YIR VNFNGS Sbjct: 395 SYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGS 454 Query: 461 AGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPA 520 AGTPV FN+NGDAPGRYDIFQYQ TN S Y++IG WT++L L +EDMQW PA Sbjct: 455 AGTPVTFNENGDAPGRYDIFQYQITNKSTE-YKVIGHWTNQLHLKVEDMQWAHREHTHPA 513 Query: 521 SVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIP 580 SVC+LPCKPG+RKKT KG PCCW CE C+GY YQ DE++C+ CP DQRPN NRTGCQ IP Sbjct: 514 SVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIP 573 Query: 581 IIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCY 640 IIKLEWHSPWAV+PVF+A+LGIIAT FV+ TF+RYNDTPIVRASGRELSYVLLTGIFLCY Sbjct: 574 IIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCY 633 Query: 641 IITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPT 700 ITFLMIA PD +CSFRRVFLGLGMC SYAALLTKTNRI+RIFEQGKKSVTAP+ ISP Sbjct: 634 SITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPA 693 Query: 701 SQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSL 760 SQL IT SLISVQLLGVF+WF VDPP+IIIDY E +T++PE+ARGVLKCDI+DL +ICSL Sbjct: 694 SQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSL 753 Query: 761 GYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYI 820 GYSILLMVTCTVYAIKTRGVPE FNEAKPIGFTMYTTCI+WLAFIPIFFGTAQSAEK+YI Sbjct: 754 GYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813 Query: 821 QTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKP 880 QTTTLT+SM+LSASV+LGMLYMPKVYIIIFHPE NVQKRKRSFKAVVTAATM S+L K Sbjct: 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKG 873 Query: 881 SDRPNGEAKTELCENVDPNSPAA 903 +DRPNGE K+ELCE+++ NS ++ Sbjct: 874 NDRPNGEVKSELCESLETNSKSS 896 >gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] Length = 912 Score = 1316 bits (3406), Expect = 0.0 Identities = 633/903 (70%), Positives = 761/903 (84%), Gaps = 5/903 (0%) Query: 15 KFPCCVLEVLLCALAAAARGQEMYAPH--SIRIEGDVTLGGLFPVHAKGPSGVPCGDIKR 72 + P C+L L ++ G+ PH SIRI+GD+TLGGLFPVH +G G PCG++K+ Sbjct: 13 RLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKK 72 Query: 73 ENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTS 132 E GIHRLEAML+ALD+IN+DP+LLPN+TLGARILDTCSRDT+ALEQSLTFVQALI+KD + Sbjct: 73 EKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGT 132 Query: 133 DVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRY 192 +VRC +G PP+ KPE+VVGVIGASGSSVSIMVANILRLF+IPQISYASTAP+LSD+ RY Sbjct: 133 EVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRY 192 Query: 193 DFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQ 252 DFFSRVVP D++QAQAMVDIV+AL WNYVST+ASEGSYGE GVE+F Q S+E GG+CIAQ Sbjct: 193 DFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQ 252 Query: 253 SVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVG 312 SV+IP+E K +FD+II++LL+T N+RAV+IFAN++DI+++L AA+RA+Q GHF W+G Sbjct: 253 SVKIPREPKAG--EFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMG 310 Query: 313 SDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENF 372 SDSWGSKI P+ E++AEGA+TI PKR +V GFD YF+SRTL+NNRRN+WFAE+WE+NF Sbjct: 311 SDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNF 370 Query: 373 NCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCAD 432 +CKL+ KK +KCT +ERIG+DS YEQEGKVQFVIDAVYAM HALH M++DLC Sbjct: 371 HCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPG 430 Query: 433 YRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGY 492 G+CP M+ G +LLKYIRNVNF+G AG PV FN+NGDAPGRYDI+QYQ N S Y Sbjct: 431 RVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAE-Y 489 Query: 493 RLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQ 552 ++IG WTD L L IE M W +++P S+C+LPC+PG+RKKT KG PCCW CEPC GYQ Sbjct: 490 KVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQ 549 Query: 553 YQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATF 612 YQ D TC+ CPYD RP ENRTGC+ IPIIKLEW SPWAV+P+FLA++GI AT+FV+ TF Sbjct: 550 YQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITF 609 Query: 613 IRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAA 672 +RYNDTPIV+ASGRELSYVLL GIFLCY TFLMIA+PD+ CS RR+FLGLGM ISYAA Sbjct: 610 VRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAA 669 Query: 673 LLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDY 732 LLTKTNRIYRIFEQGK+SV+APR ISP SQLAIT SLIS+QLLG+ +WF VDP + ++D+ Sbjct: 670 LLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDF 729 Query: 733 DEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGF 792 + +T++P ARGVLKCDI+DL +IC LGYS+LLMVTCTVYAIKTRGVPE FNEAKPIGF Sbjct: 730 QDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGF 789 Query: 793 TMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHP 852 TMYTTCIVWLAFIPIFFGT+QSA+KLYIQTTTLT+S++LSASV+LGMLYMPKVYII+FHP Sbjct: 790 TMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHP 849 Query: 853 ELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNN 912 E NV KRKRS KAVVTAATMS++ + K + RPNGEAK+ELCEN++ + A K+ YV+Y N Sbjct: 850 EQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTN 909 Query: 913 LVI 915 I Sbjct: 910 HAI 912 >gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo sapiens] Length = 877 Score = 1218 bits (3152), Expect = 0.0 Identities = 581/857 (67%), Positives = 710/857 (82%), Gaps = 9/857 (1%) Query: 21 LEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLE 80 L V L LA A+ A S+R+ G +TLGGLFPVHA+G +G CG +K+E G+HRLE Sbjct: 11 LLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLE 70 Query: 81 AMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQK----DTSDVRC 136 AMLYALD++N+DP LLP V LGAR+LDTCSRDTYALEQ+L+FVQALI+ D VRC Sbjct: 71 AMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRC 130 Query: 137 TNGEPPVF-VKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFF 195 G PP+ PE+VV V+GAS SSVSIMVAN+LRLF IPQISYASTAPELSD RYDFF Sbjct: 131 PGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFF 190 Query: 196 SRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVR 255 SRVVPPDS+QAQAMVDIV+ALGWNYVSTLASEG+YGE GVE+F QIS+EAGG+CIAQS++ Sbjct: 191 SRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIK 250 Query: 256 IPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDS 315 IP+E K +F ++I++L++TPN+R ++IFAN++DI+++L AA++A+ GHFLWVGSDS Sbjct: 251 IPREPKPG--EFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDS 308 Query: 316 WGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCK 375 WG+K +P+ ED+A GAITI PKRA+++GFD YF +R+LENNRRN+WFAE+WEENFNCK Sbjct: 309 WGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCK 368 Query: 376 LTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRG 435 LT SG++ +D+ RKCTG+ERIG+DS YEQEGKVQFVIDAVYA+AHALH M++ LC + G Sbjct: 369 LTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTG 428 Query: 436 VCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTN--TSNPGYR 493 +CP ME G+ LL+YIR V FNGSAGTPVMFN+NGDAPGRYDIFQYQ TN S+ GY+ Sbjct: 429 LCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQ 488 Query: 494 LIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQY 553 +GQW + L+L++E +QW E+P+S+C+LPC PG+RKK KG PCCW CE CDGY++ Sbjct: 489 AVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRF 548 Query: 554 QFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFI 613 Q DE TC+ CP D RP N TGC+ P+++L W SPWA P+ LA+LGI+AT V+ATF+ Sbjct: 549 QVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFV 608 Query: 614 RYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAAL 673 RYN+TPIVRASGRELSYVLLTGIFL Y ITFLM+A+P AVC+ RR+FLGLG +SY+AL Sbjct: 609 RYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSAL 668 Query: 674 LTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYD 733 LTKTNRIYRIFEQGK+SVT P ISPTSQL IT SL S+Q++G+ W G PP+ +IDY+ Sbjct: 669 LTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYE 728 Query: 734 EHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFT 793 E +T++PEQARGVLKCD++DL +I LGYS+LLMVTCTVYAIK RGVPE FNEAKPIGFT Sbjct: 729 EQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFT 788 Query: 794 MYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPE 853 MYTTCI+WLAF+PIFFGTAQSAEK+YIQTTTLT+S++LSASV+LGMLY+PK Y+I+FHPE Sbjct: 789 MYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPE 848 Query: 854 LNVQKRKRSFKAVVTAA 870 NVQKRKRS KA T A Sbjct: 849 QNVQKRKRSLKATSTVA 865 >gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo sapiens] Length = 879 Score = 732 bits (1889), Expect = 0.0 Identities = 387/849 (45%), Positives = 528/849 (62%), Gaps = 34/849 (4%) Query: 21 LEVLLCALAAA----ARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGI 76 L+VL AL + + G + I+IEGD+ LGGLFP++ KG CG I + GI Sbjct: 7 LQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGI 66 Query: 77 HRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQK-DTSDVR 135 RLEAML+A+D+IN D LLP V LG ILDTCSRDTYALEQSL FV+A + K D ++ Sbjct: 67 QRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYM 126 Query: 136 CTNGEPPVFVK-PEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDF 194 C +G + P + GVIG S SSVSI VAN+LRLFQIPQISYAST+ +LSD RYD+ Sbjct: 127 CPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 186 Query: 195 FSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSV 254 F+R VPPD +QA+AM +I++ W YVST+ASEG YGE G+E+F Q ++ +CIA + Sbjct: 187 FARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEAR-LRNICIATAE 245 Query: 255 RIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSD 314 ++ + ++ +D +I++LL PN+R VV+F +D ++++AAA RA+ F WV SD Sbjct: 246 KVGRSNIRKS--YDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRAN--ASFTWVASD 301 Query: 315 SWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNC 374 WG++ + + E +A GAIT++ V FD YF S NN RN WF ++WE+ F C Sbjct: 302 GWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQC 361 Query: 375 KLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYR 434 L K + R C I SNYEQE K+ FV++AVYAMAHALH M + LC + Sbjct: 362 SL----QNKRNHRRVCDKHLAIDS-SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTT 416 Query: 435 GVCPEMEQAGGKKLLK-YIRNVNF------NGSAGTPVMFNKNGDAPGRYDIFQYQTTNT 487 +C M+ GKKL K Y+ +NF N A + V F+ GD GRY++F +Q Sbjct: 417 KLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVG- 475 Query: 488 SNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEP 547 Y +G W + L L++ + W + +P S C+ PC P + K Q G CCW C P Sbjct: 476 GKYSYLKVGHWAETLSLDVNSIHWSRN--SVPTSQCSDPCAPNEMKNMQPGDVCCWICIP 533 Query: 548 CDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIF 607 C+ Y+Y DE TC C Q P + TGC D+P + W WA+ PV +A LG + T Sbjct: 534 CEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCM 593 Query: 608 VMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMC 667 V+ FI++N+TP+V+ASGREL Y+LL G+ L Y +TF IAKP +C+ RR+ LG Sbjct: 594 VVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFA 653 Query: 668 ISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPN 727 I Y+ALLTKTN I RIF+ K P+ ISP+SQ+ I LI VQ++ V +W ++ P Sbjct: 654 ICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPG 713 Query: 728 IIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEA 787 T+ ++ +LKC++ D ++ SL Y ++L++ CTVYA KTR PENFNEA Sbjct: 714 -----TRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEA 768 Query: 788 KPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYI 847 K IGFTMYTTCI+WLAF+PIF+ T+ +QTTT+ IS++LS V LG L+ PKV+I Sbjct: 769 KFIGFTMYTTCIIWLAFLPIFYVTSSDYR---VQTTTMCISVSLSGFVVLGCLFAPKVHI 825 Query: 848 IIFHPELNV 856 I+F P+ NV Sbjct: 826 ILFQPQKNV 834 >gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor [Homo sapiens] Length = 872 Score = 720 bits (1858), Expect = 0.0 Identities = 388/865 (44%), Positives = 524/865 (60%), Gaps = 39/865 (4%) Query: 21 LEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLE 80 L LL A A G A + +EGD+ LGGLFPVH KG CG + GI RLE Sbjct: 7 LLALLLLWGAVAEGP---AKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLE 63 Query: 81 AMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVR--CTN 138 AML+ALD+IN DP+LLP V LGA ILD+CS+DT+ALEQ+L FV+A + + R C + Sbjct: 64 AMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPD 123 Query: 139 GEPPVFVK-PEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSR 197 G P + GVIG S S VSI VAN+LRLFQIPQISYAST+ +LSD RYD+F+R Sbjct: 124 GSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183 Query: 198 VVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIP 257 VPPD FQA+AM +I++ W YVST+ASEG YGE G+E+F ++ A +C+A S ++ Sbjct: 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAF-ELEARARNICVATSEKVG 242 Query: 258 QERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWG 317 + F+ +++ LL P++R V+F ED +++LAA++R + F WV SD WG Sbjct: 243 RAMSRAA--FEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLN--ASFTWVASDGWG 298 Query: 318 SKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLT 377 + + + E AEGAITI+ + F +YF S NN RN WF E+WE+ F C Sbjct: 299 ALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFR 358 Query: 378 ISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVC 437 R C + +EQE K+ FV++AVYAMAHALH+M++ LC + +C Sbjct: 359 ---------QRDCAAHSL--RAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLC 407 Query: 438 PEMEQAGGKKLLK-YIRNVNFNG-----SAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPG 491 M G++L K ++ NV F+ V F++ GD GRY+IF Y + Sbjct: 408 DAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYR 467 Query: 492 YRLIGQWTDELQLNIEDMQWGK-GVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDG 550 Y+ +G W + L L+ + W +PAS C+ PC + K Q G CCW C PC Sbjct: 468 YQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQP 527 Query: 551 YQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMA 610 Y+Y+ DE TC C PN + TGC ++P + W WAV PV +A LG +AT+FV+ Sbjct: 528 YEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLG 587 Query: 611 TFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISY 670 F+R+N TP+V+ASGREL Y+LL G+FLCY +TF+ IAKP AVC+ RR+ LG + Y Sbjct: 588 VFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCY 647 Query: 671 AALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIII 730 +ALLTKTNRI RIF ++ PR ISP SQ+AI +LIS QLL V W V+ P Sbjct: 648 SALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPG--- 704 Query: 731 DYDEHKTMNPEQARGV-LKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKP 789 K PE+ V L+C+ D ++ SL Y++LL+ CT+YA KTR PENFNEAK Sbjct: 705 ---TGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKF 761 Query: 790 IGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIII 849 IGFTMYTTCI+WLAF+PIF+ T+ +QTTT+ +S++LS SV LG L+ PK++II+ Sbjct: 762 IGFTMYTTCIIWLAFLPIFYVTSSDYR---VQTTTMCVSVSLSGSVVLGCLFAPKLHIIL 818 Query: 850 FHPELNVQKRKRSFKAVVTAATMSS 874 F P+ NV + +AA +S Sbjct: 819 FQPQKNVVSHRAPTSRFGSAAARAS 843 >gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor [Homo sapiens] Length = 1212 Score = 644 bits (1661), Expect = 0.0 Identities = 351/850 (41%), Positives = 509/850 (59%), Gaps = 33/850 (3%) Query: 20 VLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGV----PCGDIKRENG 75 +L VLL Q + GD+ +G LF VH + CG ++ + G Sbjct: 6 ILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYG 65 Query: 76 IHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQ-ALIQKDTSD- 133 I R+EAML+ L++INSDP LLPN+TLG I D+C ALEQS+ F++ +LI + + Sbjct: 66 IQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEG 125 Query: 134 -VRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRY 192 VRC +G F + +VGVIG SSV+I V N+L+LF IPQI+Y++T+ +LSD + Sbjct: 126 LVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLF 185 Query: 193 DFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQ 252 +F RVVP D+ QA+AMVDIVK W YVS + +EG+YGE G+E+F +S + G +CIA Sbjct: 186 KYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEG-ICIAH 244 Query: 253 SVRIPQERKDRTIDFDRIIKQLLD-TPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWV 311 S +I +++ FD+++K+L P +R V F ++ +L A +R G FL + Sbjct: 245 SYKIYSNAGEQS--FDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLL 302 Query: 312 GSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEEN 371 GSD W + + ++ A G ITI+ + V+ FD Y+ E N RN WF E+W+ Sbjct: 303 GSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHR 362 Query: 372 FNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCA 431 F C+L G +E++ T + +++ Q+ K+ FVI+A+Y+MA+ LH+M LC Sbjct: 363 FQCRL--EGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP 420 Query: 432 DYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPG 491 Y G+C M+ G+KLL+ + NF G +G ++F++NGD+PGRY+I ++ Sbjct: 421 GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD 480 Query: 492 YRLIGQWTD-ELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKG-TPCCWTCEPCD 549 Y +G W + EL+++ +D W K I SVC+ PC+ GQ K +KG CCWTC PC Sbjct: 481 YINVGSWDNGELKMD-DDEVWSKK-SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCK 538 Query: 550 GYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVM 609 +Y FDE TC+ C P ++ TGC IP+ L W P + V A LG++AT+FV Sbjct: 539 ENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVT 598 Query: 610 ATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCIS 669 FI Y DTP+V++S REL Y++L GI L Y+ TF +IAKP C +R+ +GL +S Sbjct: 599 VVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMS 658 Query: 670 YAALLTKTNRIYRIFEQGKKSVTA--PRLISPTSQLAITSSLISVQLLGVFIWFGVDPPN 727 Y+AL+TKTNRI RI KK + PR +S +QL I LI +QL + F ++PP+ Sbjct: 659 YSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPD 718 Query: 728 IIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEA 787 I+ DY P L C+ T+L ++ LGY+ LL+++CT YA KTR VP NFNEA Sbjct: 719 IMHDY-------PSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEA 771 Query: 788 KPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYI 847 K I FTMYTTCI+WLAF+PI+FG+ + T+ S++LSA+VALG +++PKVYI Sbjct: 772 KYIAFTMYTTCIIWLAFVPIYFGS-------NYKIITMCFSVSLSATVALGCMFVPKVYI 824 Query: 848 IIFHPELNVQ 857 I+ PE NV+ Sbjct: 825 ILAKPERNVR 834 >gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor [Homo sapiens] Length = 1180 Score = 644 bits (1661), Expect = 0.0 Identities = 351/850 (41%), Positives = 509/850 (59%), Gaps = 33/850 (3%) Query: 20 VLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGV----PCGDIKRENG 75 +L VLL Q + GD+ +G LF VH + CG ++ + G Sbjct: 6 ILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYG 65 Query: 76 IHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQ-ALIQKDTSD- 133 I R+EAML+ L++INSDP LLPN+TLG I D+C ALEQS+ F++ +LI + + Sbjct: 66 IQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEG 125 Query: 134 -VRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRY 192 VRC +G F + +VGVIG SSV+I V N+L+LF IPQI+Y++T+ +LSD + Sbjct: 126 LVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLF 185 Query: 193 DFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQ 252 +F RVVP D+ QA+AMVDIVK W YVS + +EG+YGE G+E+F +S + G +CIA Sbjct: 186 KYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEG-ICIAH 244 Query: 253 SVRIPQERKDRTIDFDRIIKQLLD-TPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWV 311 S +I +++ FD+++K+L P +R V F ++ +L A +R G FL + Sbjct: 245 SYKIYSNAGEQS--FDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLL 302 Query: 312 GSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEEN 371 GSD W + + ++ A G ITI+ + V+ FD Y+ E N RN WF E+W+ Sbjct: 303 GSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHR 362 Query: 372 FNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCA 431 F C+L G +E++ T + +++ Q+ K+ FVI+A+Y+MA+ LH+M LC Sbjct: 363 FQCRL--EGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP 420 Query: 432 DYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPG 491 Y G+C M+ G+KLL+ + NF G +G ++F++NGD+PGRY+I ++ Sbjct: 421 GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD 480 Query: 492 YRLIGQWTD-ELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKG-TPCCWTCEPCD 549 Y +G W + EL+++ +D W K I SVC+ PC+ GQ K +KG CCWTC PC Sbjct: 481 YINVGSWDNGELKMD-DDEVWSKK-SNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCK 538 Query: 550 GYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVM 609 +Y FDE TC+ C P ++ TGC IP+ L W P + V A LG++AT+FV Sbjct: 539 ENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVT 598 Query: 610 ATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCIS 669 FI Y DTP+V++S REL Y++L GI L Y+ TF +IAKP C +R+ +GL +S Sbjct: 599 VVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMS 658 Query: 670 YAALLTKTNRIYRIFEQGKKSVTA--PRLISPTSQLAITSSLISVQLLGVFIWFGVDPPN 727 Y+AL+TKTNRI RI KK + PR +S +QL I LI +QL + F ++PP+ Sbjct: 659 YSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPD 718 Query: 728 IIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEA 787 I+ DY P L C+ T+L ++ LGY+ LL+++CT YA KTR VP NFNEA Sbjct: 719 IMHDY-------PSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEA 771 Query: 788 KPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYI 847 K I FTMYTTCI+WLAF+PI+FG+ + T+ S++LSA+VALG +++PKVYI Sbjct: 772 KYIAFTMYTTCIIWLAFVPIYFGS-------NYKIITMCFSVSLSATVALGCMFVPKVYI 824 Query: 848 IIFHPELNVQ 857 I+ PE NV+ Sbjct: 825 ILAKPERNVR 834 >gi|166999223 glutamate receptor, metabotropic 1 isoform beta precursor [Homo sapiens] Length = 906 Score = 642 bits (1657), Expect = 0.0 Identities = 365/869 (42%), Positives = 519/869 (59%), Gaps = 47/869 (5%) Query: 11 LTLMKFPCCVLEVLLC-------ALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPS 63 L L FP LEV L L A A Q A R++GDV +G LF VH + P+ Sbjct: 4 LLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVA----RMDGDVIIGALFSVHHQPPA 59 Query: 64 G-VP---CGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQS 119 VP CG+I+ + GI R+EAM + LD+IN+DP LLPN+TLG+ I D+C + ALEQS Sbjct: 60 EKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQS 119 Query: 120 LTFVQALI-----QKDTSDVRCTNGE--PPVFVKPEKVVGVIGASGSSVSIMVANILRLF 172 + F++ + +KD + +G+ PP K + + GVIG SSV+I V N+L+LF Sbjct: 120 IEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK-KPIAGVIGPGSSSVAIQVQNLLQLF 178 Query: 173 QIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGE 232 IPQI+Y++T+ +LSD Y +F RVVP D+ QA+AM+DIVK W YVS + +EG+YGE Sbjct: 179 DIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGE 238 Query: 233 KGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDT-PNSRAVVIFANDED 291 G+++F +++ + G LCIA S +I +++ FDR++++L + P +R VV F Sbjct: 239 SGMDAFKELAAQEG-LCIAHSDKIYSNAGEKS--FDRLLRKLRERLPKARVVVCFCEGMT 295 Query: 292 IKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFT 351 ++ +L+A +R VG F +GSD W + + +E A G ITI+ + V FD YF Sbjct: 296 VRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFL 355 Query: 352 SRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFV 411 L+ N RN WF E+W+ F C+L + + R CTG E + + NY Q+ K+ FV Sbjct: 356 KLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESL--EENYVQDSKMGFV 413 Query: 412 IDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNG 471 I+A+YAMAH L +M+ LC + G+C M+ G KLL ++ +F G +G V F++ G Sbjct: 414 INAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKG 473 Query: 472 DAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQ 531 DAPGRYDI Q T + Y +G W + + LNI+D + + SVC+ PC GQ Sbjct: 474 DAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQMNKSGVVRSVCSEPCLKGQ 532 Query: 532 RKKTQKG-TPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPW 590 K +KG CCW C C +Y DE TC+ C PN + TGC+ IP+ LEW + Sbjct: 533 IKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIE 592 Query: 591 AVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKP 650 ++I + + LGI+ T+FV F+ Y DTP+V++S REL Y++L GIFL Y+ F +IAKP Sbjct: 593 SIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKP 652 Query: 651 DVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTA--PRLISPTSQLAITSS 708 C +R+ +GL + Y+AL+TKTNRI RI KK + PR +S +Q+ I S Sbjct: 653 TTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASI 712 Query: 709 LISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMV 768 LISVQL V ++PP I+ Y K + L C+ ++L ++ LGY+ LL++ Sbjct: 713 LISVQLTLVVTLIIMEPPMPILSYPSIKEV-------YLICNTSNLGVVAPLGYNGLLIM 765 Query: 769 TCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTIS 828 +CT YA KTR VP NFNEAK I FTMYTTCI+WLAF+PI+FG+ I TT +S Sbjct: 766 SCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGS-----NYKIITTCFAVS 820 Query: 829 MNLSASVALGMLYMPKVYIIIFHPELNVQ 857 LS +VALG ++ PK+YIII PE NV+ Sbjct: 821 --LSVTVALGCMFTPKMYIIIAKPERNVR 847 >gi|166999098 glutamate receptor, metabotropic 1 isoform alpha precursor [Homo sapiens] Length = 1194 Score = 642 bits (1657), Expect = 0.0 Identities = 365/869 (42%), Positives = 519/869 (59%), Gaps = 47/869 (5%) Query: 11 LTLMKFPCCVLEVLLC-------ALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPS 63 L L FP LEV L L A A Q A R++GDV +G LF VH + P+ Sbjct: 4 LLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVA----RMDGDVIIGALFSVHHQPPA 59 Query: 64 G-VP---CGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQS 119 VP CG+I+ + GI R+EAM + LD+IN+DP LLPN+TLG+ I D+C + ALEQS Sbjct: 60 EKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQS 119 Query: 120 LTFVQALI-----QKDTSDVRCTNGE--PPVFVKPEKVVGVIGASGSSVSIMVANILRLF 172 + F++ + +KD + +G+ PP K + + GVIG SSV+I V N+L+LF Sbjct: 120 IEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK-KPIAGVIGPGSSSVAIQVQNLLQLF 178 Query: 173 QIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGE 232 IPQI+Y++T+ +LSD Y +F RVVP D+ QA+AM+DIVK W YVS + +EG+YGE Sbjct: 179 DIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGE 238 Query: 233 KGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDT-PNSRAVVIFANDED 291 G+++F +++ + G LCIA S +I +++ FDR++++L + P +R VV F Sbjct: 239 SGMDAFKELAAQEG-LCIAHSDKIYSNAGEKS--FDRLLRKLRERLPKARVVVCFCEGMT 295 Query: 292 IKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFT 351 ++ +L+A +R VG F +GSD W + + +E A G ITI+ + V FD YF Sbjct: 296 VRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFL 355 Query: 352 SRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFV 411 L+ N RN WF E+W+ F C+L + + R CTG E + + NY Q+ K+ FV Sbjct: 356 KLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESL--EENYVQDSKMGFV 413 Query: 412 IDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNG 471 I+A+YAMAH L +M+ LC + G+C M+ G KLL ++ +F G +G V F++ G Sbjct: 414 INAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKG 473 Query: 472 DAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQ 531 DAPGRYDI Q T + Y +G W + + LNI+D + + SVC+ PC GQ Sbjct: 474 DAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQMNKSGVVRSVCSEPCLKGQ 532 Query: 532 RKKTQKG-TPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPW 590 K +KG CCW C C +Y DE TC+ C PN + TGC+ IP+ LEW + Sbjct: 533 IKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIE 592 Query: 591 AVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKP 650 ++I + + LGI+ T+FV F+ Y DTP+V++S REL Y++L GIFL Y+ F +IAKP Sbjct: 593 SIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKP 652 Query: 651 DVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTA--PRLISPTSQLAITSS 708 C +R+ +GL + Y+AL+TKTNRI RI KK + PR +S +Q+ I S Sbjct: 653 TTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASI 712 Query: 709 LISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMV 768 LISVQL V ++PP I+ Y K + L C+ ++L ++ LGY+ LL++ Sbjct: 713 LISVQLTLVVTLIIMEPPMPILSYPSIKEV-------YLICNTSNLGVVAPLGYNGLLIM 765 Query: 769 TCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTIS 828 +CT YA KTR VP NFNEAK I FTMYTTCI+WLAF+PI+FG+ I TT +S Sbjct: 766 SCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGS-----NYKIITTCFAVS 820 Query: 829 MNLSASVALGMLYMPKVYIIIFHPELNVQ 857 LS +VALG ++ PK+YIII PE NV+ Sbjct: 821 --LSVTVALGCMFTPKMYIIIAKPERNVR 847 >gi|37577159 calcium-sensing receptor [Homo sapiens] Length = 1078 Score = 401 bits (1030), Expect = e-111 Identities = 289/948 (30%), Positives = 441/948 (46%), Gaps = 91/948 (9%) Query: 14 MKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVH----------AKGPS 63 M F C +L +A G + A +GD+ LGGLFP+H P Sbjct: 1 MAFYSCCWVLLALTWHTSAYGPDQRAQK----KGDIILGGLFPIHFGVAAKDQDLKSRPE 56 Query: 64 GVPCGDIKREN--GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLT 121 V C R N G L+AM++A+++INS P LLPN+TLG RI DTC+ + ALE +L+ Sbjct: 57 SVEC---IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLS 113 Query: 122 FV-QALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA 180 FV Q I D C E + V+GA+GS VS VAN+L LF IPQ+SYA Sbjct: 114 FVAQNKIDSLNLDEFCNCSE-----HIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYA 168 Query: 181 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ 240 S++ LS+ ++ F R +P D QA AM DI++ WN+V T+A++ YG G+E F + Sbjct: 169 SSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFRE 228 Query: 241 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK 300 ++E +CI S I Q + I + +++ ++ +V+F++ D++ ++ Sbjct: 229 EAEERD-ICIDFSELISQYSDEEEIQH---VVEVIQNSTAKVIVVFSSGPDLEPLIKEIV 284 Query: 301 RADQVGHFLWVGSDSWGSK-INPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNR 359 R + G +W+ S++W S + + Q+ + G I K + GF + + Sbjct: 285 RRNITGK-IWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSV 343 Query: 360 RNVWFAEYWEENFNCKL-----------TISGSKKEDTDR----------KCTGQERIGK 398 N + E+WEE FNC L T +E DR CTG E I Sbjct: 344 HNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISS 403 Query: 399 -DSNYEQEGKVQF---VIDAVYAMAHALHHMNKDLCADYRGV-----CPEMEQAGGKKLL 449 ++ Y ++ V AVY++AHAL + C RG+ C ++++ ++L Sbjct: 404 VETPYIDYTHLRISYNVYLAVYSIAHALQDIYT--CLPGRGLFTNGSCADIKKVEAWQVL 461 Query: 450 KYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNP-------GYRLIGQWTDEL 502 K++R++NF + G V F++ GD G Y I + + Y + + + L Sbjct: 462 KHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERL 521 Query: 503 QLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP-CCWTCEPC-DG-YQYQFDEMT 559 +N E + W RE+P S C+ C G RK +G P CC+ C C DG Y + D Sbjct: 522 FINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASA 581 Query: 560 CQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTP 619 C CP D NEN T C I L W P+ + A+LGI T FV+ FI++ +TP Sbjct: 582 CNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTP 641 Query: 620 IVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNR 679 IV+A+ RELSY+LL + C+ + I +P C R+ G+ + + +L KTNR Sbjct: 642 IVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNR 701 Query: 680 IYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMN 739 + +FE + + Q + +Q++ IW PP+ ++ Sbjct: 702 VLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPS------SYRNQE 755 Query: 740 PEQARGVLKCDITDLQIICSL-GYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTC 798 E + C L + L GY+ LL C +A K+R +PENFNEAK I F+M Sbjct: 756 LEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFF 815 Query: 799 IVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQK 858 IVW++FIP + T L S L L ++ K+YII+F P N + Sbjct: 816 IVWISFIPAYASTYGKFVSAVEVIAILAASFGL-----LACIFFNKIYIILFKPSRNTIE 870 Query: 859 RKR------SFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS 900 R +FK A S +S K S G + ++ S Sbjct: 871 EVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKS 918 >gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] Length = 839 Score = 241 bits (615), Expect = 2e-63 Identities = 233/874 (26%), Positives = 384/874 (43%), Gaps = 107/874 (12%) Query: 24 LLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIK---------REN 74 LL LA A + Y P GD LGGLF +HA V ++ + Sbjct: 14 LLWVLAEPAENSDFYLP------GDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVI 67 Query: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTC--SRDTYALEQSLTFVQAL--IQKD 130 G + ++AM +A+++IN+D +LLP V LG I+D C S + + L L IQ+D Sbjct: 68 GYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQED 127 Query: 131 TSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDR 190 S+ +VV VIG S + VAN L LF +PQI+Y++ + EL D Sbjct: 128 YSNYI------------SRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKV 175 Query: 191 RYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYG-EKGVESFTQISKEAGGLC 249 R+ R P +AMV ++ WN++ L S +YG + G ++++ +C Sbjct: 176 RFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARR--DIC 233 Query: 250 IAQSVRIPQERKDRTIDFDR-----IIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQ 304 IA +P + ++ + + I L +R VV+F+ D + R + Sbjct: 234 IAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNF 293 Query: 305 VGHFLWVGSDSWGSKINP-LHQHEDIAEGA----ITIQPKRATVEGFDAYFTSRTLENNR 359 G +W+ S+SW I+P LH ++ ITIQ + GF + Sbjct: 294 TGA-VWIASESWA--IDPVLHNLTELRHLGTFLGITIQS--VPIPGFSEFREWGPQAGPP 348 Query: 360 RNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMA 419 ++ + N C ++ + +T + +G ER+ V V AVYA+A Sbjct: 349 PLSRTSQSYTCNQECDNCLNATLSFNTILRLSG-ERV-----------VYSVYSAVYAVA 396 Query: 420 HALHHM---NKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGR 476 HALH + +K C R V P +LL+ I VNF + F+ GD Sbjct: 397 HALHSLLGCDKSTCTK-RVVYPW-------QLLEEIWKVNFT-LLDHQIFFDPQGDVALH 447 Query: 477 YDIFQYQTTNTSNPGYRLIGQWTDELQL-NIEDMQWGKGVREIPASVCTLPCKPGQRKKT 535 +I Q+Q + NP + + + QL NI+D+ W IP S+C+ C+ GQ+KK Sbjct: 448 LEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKP 507 Query: 536 QKGTPCCWTCEPC---DGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAV 592 CC+ C C + DE CQ CP ++ ++ T C ++ LEWH + Sbjct: 508 VGIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTI 567 Query: 593 IPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDV 652 LA LG ++T+ ++ F R+ TPIVR++G + +++LT + + Y++ + + P V Sbjct: 568 AVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKV 627 Query: 653 AVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTA----PRLISPTSQLAITSS 708 + C R+ L I + + ++ +I F+ + A R P +A + Sbjct: 628 STCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITV 687 Query: 709 LISVQLLGVFIWFGVDPPNIIIDYDEHK----TMNPEQARGVLKCDITDLQIICSLGYSI 764 L V ++ + G+ P D D+ K + NP +L DL Sbjct: 688 LKMVIVVIGMLATGLS-PTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDL---------- 736 Query: 765 LLMVTCTVYAIKTRGVPENFNEAKPIGFTM---YTTCIVWLAFIPIFFGTAQSAEKLYIQ 821 LL V +A + +P N+NEAK I +M +T+ + F+ + G + L + Sbjct: 737 LLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVT 796 Query: 822 TTTLTISMNLSASVALGMLYMPKVYIIIFHPELN 855 L +++LG + PK Y+I+F+PE N Sbjct: 797 VLNL-------LAISLG-YFGPKCYMILFYPERN 822 >gi|112807234 G protein-coupled receptor, family C, group 6, member A [Homo sapiens] Length = 926 Score = 230 bits (587), Expect = 4e-60 Identities = 220/857 (25%), Positives = 379/857 (44%), Gaps = 90/857 (10%) Query: 47 GDVTLGGLFPVHAK---------GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLP 97 G + +GGLF +H K P C + + L AM+++++ IN+ LLP Sbjct: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTL-AMIHSIEMINNS-TLLP 91 Query: 98 NVTLGARILDTCSRDTYALEQSLTFVQAL-IQKDTSDVRCTNGEPPVFVKPEKVVGVIGA 156 V LG I DTC+ T A+ +L F+ ++T + +C VK VIG+ Sbjct: 92 GVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVK-----AVIGS 146 Query: 157 SGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKAL 216 S +++ V+ +L L +PQ+ Y STA LSD R+ F R VP D Q +AM +++ Sbjct: 147 GYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKS 206 Query: 217 GWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTID--FDRIIKQL 274 GWN++ + ++ YG + +F I EA +CIA +P D TI+ +R +K++ Sbjct: 207 GWNWIGIITTDDDYGRLALNTFI-IQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKI 265 Query: 275 LDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGS--KINPLHQHEDIAEG 332 + +V+F + + K + + +W+ SD+W + KI + + I + Sbjct: 266 ILEAQVNVIVVFLRQFHVFDLFN--KAIEMNINKMWIASDNWSTATKITTIPNVKKIGK- 322 Query: 333 AITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTD-RKCT 391 + +R + F ++ + L + + EY C +DTD +C Sbjct: 323 VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYV------KDTDLSQCI 376 Query: 392 ---GQERIGKDSN----------------YEQEGKVQFVIDAVYAMAHALHHMNKDLCAD 432 Q + +N Y + G + + AV+A+ +A+ +DLC Sbjct: 377 FNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAI----RDLCQA 432 Query: 433 YRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGY 492 P Q +LL ++NV F + F+ +GD YD+ ++ N G+ Sbjct: 433 RDCQNPNAFQPW--ELLGVLKNVTFTDGWNS-FHFDAHGDLNTGYDVVLWKEIN----GH 485 Query: 493 RLIGQWTD-ELQLN---IEDMQWGKGVREIPA--SVCTLPCKPGQRKKTQKGTP-CCWTC 545 + + + +LQ + I D + R + S C+ C PGQ KKT + CC+ C Sbjct: 486 MTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYEC 545 Query: 546 EPC--DGYQYQFDEMTCQHCPYDQRPNENR-TGCQDIPIIKLEWHSPWAVIPVFLAMLGI 602 + C + Y Q D C C R T C + + L W+ A++ + L++LGI Sbjct: 546 QNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGI 605 Query: 603 IATIFVMATFIRYNDTPIVRAS-GRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVF 661 I + V F R +TP+V++S G + YV+L FL + T I +P C R+ Sbjct: 606 IFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTM 665 Query: 662 LGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWF 721 G+ + + +LTK+ +I F K + + + I + +Q++ +W Sbjct: 666 FGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCL--YRPILIIFTCTGIQVVICTLWL 723 Query: 722 GVDPPNIIIDYDEHKTMNPEQARGVLKCDI-TDLQIICSLGYSILLMVTCTVYAIKTRGV 780 P + ++ + + +L+C+ + L LGY +L C ++A K G Sbjct: 724 IFAAPTVEVNVSLPRVI-------ILECEEGSILAFGTMLGYIAILAFICFIFAFK--GK 774 Query: 781 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML 840 EN+NEAK I F M I W+ FIPI+ T Y+ + + + +S L Sbjct: 775 YENYNEAKFITFGMLIYFIAWITFIPIYATTFGK----YVPAVEIIVIL-ISNYGILYCT 829 Query: 841 YMPKVYIIIFHPELNVQ 857 ++PK Y+II E+N + Sbjct: 830 FIPKCYVIICKQEINTK 846 >gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] Length = 852 Score = 209 bits (531), Expect = 1e-53 Identities = 207/872 (23%), Positives = 371/872 (42%), Gaps = 89/872 (10%) Query: 20 VLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGV--------PCGDIK 71 VL + L AL G + +R++GD LGGLFP+ +G+ P Sbjct: 6 VLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRF 65 Query: 72 RENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDT 131 NG+ AM A+++IN+ +LLP + LG + DTCS A++ SL F+ +D Sbjct: 66 SSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDI 125 Query: 132 SDV-RCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDR 190 + T +P +V+ VIG S ++++ F +PQ+SY ++ LS Sbjct: 126 AAYCNYTQYQP-------RVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARE 178 Query: 191 RYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCI 250 + F R VP D Q A ++++ GWN+V+ L S+ YG +G+ F+ ++ A G+CI Sbjct: 179 TFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALA-AARGICI 237 Query: 251 AQSVRIPQERKD--RTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHF 308 A +P R D R ++ Q+ +S VV+ L + ++ Sbjct: 238 AHEGLVPLPRADDSRLGKVQDVLHQV--NQSSVQVVLLFASVHAAHALFNYSISSRLSPK 295 Query: 309 LWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYW 368 +WV S++W + D+ G + + TV GF L+ + F +Y Sbjct: 296 VWVASEAWLT--------SDLVMG-LPGMAQMGTVLGF--------LQRGAQLHEFPQYV 338 Query: 369 EENFNCK-----LTISGSKKEDTDRKCTGQ----------ERIGKDSNYEQEGKVQFVID 413 + + + G +++ + GQ + + N+ Q V Sbjct: 339 KTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFS---VYA 395 Query: 414 AVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDA 473 AVY++A ALH+ L + G CP + +LL+ + N+ F+ G P+ F+ +G+ Sbjct: 396 AVYSVAQALHN---TLQCNASG-CPAQDPVKPWQLLENMYNLTFH-VGGLPLRFDSSGNV 450 Query: 474 PGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRK 533 YD+ + S P +G++ L+ ++W + P S C+ C+ GQ + Sbjct: 451 DMEYDL-KLWVWQGSVPRLHDVGRFNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVR 509 Query: 534 KTQKGTPCCWTCEPCD--GYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWA 591 + + CC+ C C+ Y+ D++ C C D+ E T C L W P Sbjct: 510 RVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAV 569 Query: 592 VIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPD 651 ++ + L L + + + F+ + D+P+V+ASG L+ L + L + L +P Sbjct: 570 LLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLACFGLVCLGLVCLSVLLFPGQPS 629 Query: 652 VAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLI----SPTSQLAI-T 706 A C ++ L + + L + I+ E A RL P + L + Sbjct: 630 PARCLAQQPLSHLPLTGCLSTLFLQAAEIF--VESELPLSWADRLSGCLRGPWAWLVVLL 687 Query: 707 SSLISVQLLGVFIWFGVD-PPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGY--S 763 + L+ V L W+ V PP ++ D+ M P +A ++ C T + L + + Sbjct: 688 AMLVEVALC---TWYLVAFPPEVVTDWH----MLPTEA--LVHCR-TRSWVSFGLAHATN 737 Query: 764 ILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTT 823 L C + R P +N A+ + F M I W++F+P+ ++ ++ Sbjct: 738 ATLAFLCFLGTFLVRSQPGRYNRARGLTFAMLAYFITWVSFVPLLANV-----QVVLRPA 792 Query: 824 TLTISMNLSASVALGMLYMPKVYIIIFHPELN 855 ++ L L ++P+ Y+++ P LN Sbjct: 793 VQMGALLLCVLGILAAFHLPRCYLLMRQPGLN 824 >gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo sapiens] Length = 254 Score = 207 bits (526), Expect = 5e-53 Identities = 113/234 (48%), Positives = 150/234 (64%), Gaps = 10/234 (4%) Query: 642 ITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTS 701 +TF+ IAKP AVC+ RR+ LG + Y+ALLTKTNRI RIF ++ PR ISP S Sbjct: 1 MTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPAS 60 Query: 702 QLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGV-LKCDITDLQIICSL 760 Q+AI +LIS QLL V W V+ P K PE+ V L+C+ D ++ SL Sbjct: 61 QVAICLALISGQLLIVVAWLVVEAPGT------GKETAPERREVVTLRCNHRDASMLGSL 114 Query: 761 GYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYI 820 Y++LL+ CT+YA KTR PENFNEAK IGFTMYTTCI+WLAF+PIF+ T+ + Sbjct: 115 AYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYR---V 171 Query: 821 QTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSS 874 QTTT+ +S++LS SV LG L+ PK++II+F P+ NV + +AA +S Sbjct: 172 QTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARAS 225 >gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] Length = 841 Score = 202 bits (515), Expect = 9e-52 Identities = 210/865 (24%), Positives = 361/865 (41%), Gaps = 88/865 (10%) Query: 23 VLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHA------KGPSGVPCGDIK--REN 74 ++ C A A E + + GD L GLFP+H+ P C E+ Sbjct: 14 LISCCWAFACHSTE--SSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEH 71 Query: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCS--RDTYALEQSLTFV---QALIQK 129 G H +AM +++IN+ LLPN+TLG ++ D CS + YA + L+ +Q Sbjct: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131 Query: 130 DTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDD 189 D T V+ VIG ++ + A +L F +P ISYA+++ LS Sbjct: 132 DLLHYSPT------------VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVK 179 Query: 190 RRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLC 249 R+Y F R +P D +Q + MV +++ GW ++S + S YG+ GV++ G+C Sbjct: 180 RQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALEN-QATGQGIC 238 Query: 250 IAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFL 309 IA +P + +++ L + VV+F++ + + + + G + Sbjct: 239 IAFKDIMPFSAQVGDERMQCLMRHLAQA-GATVVVVFSSRQLARVFFESVVLTNLTGK-V 296 Query: 310 WVGSDSWGSKINPLHQHEDIAEG------AITIQPKRATVEGFDAYFTSRTLENNR--RN 361 WV S++W L +H G + + ++ V G A+ + + + R Sbjct: 297 WVASEAWA-----LSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRP 351 Query: 362 VWFAEYWEENFNCKLTISGSKKEDTDRKCTG--QERIGKDSNYEQEGKVQFVIDAVYAMA 419 + N C R+C + K + AVYA+A Sbjct: 352 CHKGSWCSSNQLC-------------RECQAFMAHTMPKLKAFSMSSAYN-AYRAVYAVA 397 Query: 420 HALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDI 479 H LH + CA G C + +LL+ I V+F T V FN N D Y+I Sbjct: 398 HGLHQLLG--CAS--GACSR-GRVYPWQLLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNI 451 Query: 480 FQYQTTNTSNPGYRLIGQWT-DELQLNIED--MQWGKGVREIPASVCTLPCKPGQRKKTQ 536 + N + ++G T +QLNI + +QW ++P SVC+ C G ++ Sbjct: 452 IAWDW-NGPKWTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVT 510 Query: 537 KGTPCCWTCEPCDG--YQYQFDEMTCQHCPYDQRPNENRTGC--QDIPIIKLEWHSPWAV 592 CC+ C PC + + D CQ C ++ E C + + + L H+ W + Sbjct: 511 GFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVL 570 Query: 593 IPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDV 652 + +L + + F + DTP+VR++G L +++L + + +P Sbjct: 571 LAANTLLL--LLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTR 628 Query: 653 AVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLIS- 711 C R+ LG I + L ++ ++ IF+ K T + + S Sbjct: 629 PACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSA 688 Query: 712 VQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITD-LQIICSLGYSILLMVTC 770 QLL W V P +Y + +L+C T+ L I + Y+ LL ++ Sbjct: 689 AQLLICLTWLVVWTPLPAREYQRFPHL------VMLECTETNSLGFILAFLYNGLLSISA 742 Query: 771 TVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMN 830 + + +PEN+NEAK + F++ + W+A FF TA + Y+ + ++ Sbjct: 743 FACSYLGKDLPENYNEAKCVTFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS 798 Query: 831 LSASVALGMLYMPKVYIIIFHPELN 855 S S G ++PK Y+I+ P+LN Sbjct: 799 -SLSSGFGGYFLPKCYVILCRPDLN 822 >gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] Length = 587 Score = 116 bits (291), Expect = 8e-26 Identities = 104/417 (24%), Positives = 180/417 (43%), Gaps = 24/417 (5%) Query: 448 LLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWT-DELQLNI 506 LL+ I V+F T V FN N D Y+I + N + ++G T +QLNI Sbjct: 167 LLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWDW-NGPKWTFTVLGSSTWSPVQLNI 224 Query: 507 ED--MQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDG--YQYQFDEMTCQH 562 + +QW ++P SVC+ C G ++ CC+ C PC + + D CQ Sbjct: 225 NETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQP 284 Query: 563 CPYDQRPNENRTGC--QDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPI 620 C ++ E C + + + L H+ W ++ +L + + F + DTP+ Sbjct: 285 CGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLL--LLLLGTAGLFAWHLDTPV 342 Query: 621 VRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRI 680 VR++G L +++L + + +P C R+ LG I + L ++ ++ Sbjct: 343 VRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQL 402 Query: 681 YRIFEQGKKSVTAPRLISPTSQLAITSSLIS-VQLLGVFIWFGVDPPNIIIDYDEHKTMN 739 IF+ K T + + S QLL W V P +Y + Sbjct: 403 IIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHL- 461 Query: 740 PEQARGVLKCDITD-LQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTC 798 +L+C T+ L I + Y+ LL ++ + + +PEN+NEAK + F++ Sbjct: 462 -----VMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNF 516 Query: 799 IVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELN 855 + W+A FF TA + Y+ + ++ S S G ++PK Y+I+ P+LN Sbjct: 517 VSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLPKCYVILCRPDLN 568 Score = 48.9 bits (115), Expect = 2e-05 Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 10/96 (10%) Query: 23 VLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHA------KGPSGVPCGDIK--REN 74 ++ C A A E + + GD L GLFP+H+ P C E+ Sbjct: 14 LISCCWAFACHSTE--SSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEH 71 Query: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCS 110 G H +AM +++IN+ LLPN+TLG ++ D CS Sbjct: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCS 107 >gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] Length = 480 Score = 105 bits (263), Expect = 1e-22 Identities = 82/307 (26%), Positives = 141/307 (45%), Gaps = 30/307 (9%) Query: 23 VLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHA------KGPSGVPCGDIK--REN 74 ++ C A A E + + GD L GLFP+H+ P C E+ Sbjct: 14 LISCCWAFACHSTE--SSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEH 71 Query: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCS--RDTYALEQSLTFV---QALIQK 129 G H +AM +++IN+ LLPN+TLG ++ D CS + YA + L+ +Q Sbjct: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQG 131 Query: 130 DTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDD 189 D T V+ VIG ++ + A +L F +P ISYA+++ LS Sbjct: 132 DLLHYSPT------------VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVK 179 Query: 190 RRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLC 249 R+Y F R +P D +Q + MV +++ GW ++S + S YG+ GV++ + G+C Sbjct: 180 RQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQAL-ENQATGQGIC 238 Query: 250 IAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFL 309 IA +P + +++ L + VV+F++ + + + + G + Sbjct: 239 IAFKDIMPFSAQVGDERMQCLMRHLAQA-GATVVVVFSSRQLARVFFESVVLTNLTGK-V 296 Query: 310 WVGSDSW 316 WV S++W Sbjct: 297 WVASEAW 303 >gi|40255245 G protein-coupled receptor 51 [Homo sapiens] Length = 941 Score = 65.1 bits (157), Expect = 3e-10 Identities = 64/284 (22%), Positives = 127/284 (44%), Gaps = 26/284 (9%) Query: 597 LAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFL-------MIAK 649 L +LG+I + I+ + +++ S ++ +++ G L Y FL + K Sbjct: 488 LTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEK 547 Query: 650 PDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSL 709 +C+ R L +G ++ A+ KT R++ IF+ K ++I L I + Sbjct: 548 TFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGM 604 Query: 710 ISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQA------RGVLK-CDITDLQIICSLGY 762 + + L + W VDP + E +M P+ A R +L+ C+ T + I + Y Sbjct: 605 LLIDLCILICWQAVDPLRRTV---EKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVY 661 Query: 763 SI--LLMVTCTVYAIKTRGVP-ENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLY 819 + LLM+ A +TR V N++K IG ++Y I+ + + F T Sbjct: 662 AYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPN--- 718 Query: 820 IQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSF 863 +Q + + + +++ L ++++PK+ + +P+ Q R+ F Sbjct: 719 VQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQF 762 Score = 57.4 bits (137), Expect = 6e-08 Identities = 64/248 (25%), Positives = 110/248 (44%), Gaps = 43/248 (17%) Query: 9 RVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCG 68 R+L L+ P LL LA A G AP +++ GL P+ + V G Sbjct: 22 RLLLLLLLP------LLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKE----VAKG 71 Query: 69 DIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQ 128 I R G+ L A+ A++QI ++ L P L R+ DT + L+ F A Sbjct: 72 SIGR--GV--LPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLK---AFYDA--- 120 Query: 129 KDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSD 188 + P ++ V G SV+ ++A L+ + + Q+S+A+T P L+D Sbjct: 121 --------------IKYGPNHLM-VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLAD 165 Query: 189 DRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGL 248 ++Y +F R VP D+ A++ ++K W V TL + V+ F+++ + G+ Sbjct: 166 KKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQD-------VQRFSEVRNDLTGV 218 Query: 249 CIAQSVRI 256 + + I Sbjct: 219 LYGEDIEI 226 >gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c precursor [Homo sapiens] Length = 899 Score = 55.5 bits (132), Expect = 2e-07 Identities = 53/208 (25%), Positives = 88/208 (42%), Gaps = 37/208 (17%) Query: 40 PHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNV 99 PHS R V +G LFP+ P G C A+ AL+ +NS ++LP+ Sbjct: 101 PHSERRA--VYIGALFPMSGGWPGGQACQP-----------AVEMALEDVNSRRDILPDY 147 Query: 100 TLGARILDT-CSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASG 158 L D+ C Q+ ++ L+ D P K++ + G S Sbjct: 148 ELKLIHHDSKCDPG-----QATKYLYELLYND----------------PIKIILMPGCS- 185 Query: 159 SSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGW 218 SVS +VA R++ + +SY S++P LS+ +R+ F R P + V + + GW Sbjct: 186 -SVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 244 Query: 219 NYVSTLASEGSYGEKGVESFTQISKEAG 246 ++T+ ++ + KEAG Sbjct: 245 KKIATIQQTTEVFTSTLDDLEERVKEAG 272 Score = 55.1 bits (131), Expect = 3e-07 Identities = 57/276 (20%), Positives = 114/276 (41%), Gaps = 27/276 (9%) Query: 597 LAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLM------IAKP 650 L+ LGI+ + ++ I + ++ S L+ + G L F + I + Sbjct: 536 LSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRN 595 Query: 651 DVA-VCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSL 709 VC R LGLG + Y ++ TK ++ +F + ++ + + P A L Sbjct: 596 QFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLL 655 Query: 710 ISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICS---------- 759 + + +L + IW VDP + I+ T E+ + + I CS Sbjct: 656 VGMDVLTLAIWQIVDPLHRTIE-----TFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGI 710 Query: 760 -LGYSILLMVTCTVYAIKTRGV-PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEK 817 GY LL++ A +T+ V E N+ + +G +Y ++ L P+ + + Sbjct: 711 FYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDA 770 Query: 818 LYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPE 853 + ++++ S+ + L +L++PK+ +I E Sbjct: 771 AF---AFASLAIVFSSYITLVVLFVPKMRRLITRGE 803 >gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b precursor [Homo sapiens] Length = 844 Score = 55.5 bits (132), Expect = 2e-07 Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 35/208 (16%) Query: 40 PHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNV 99 PH V +G LFP+ P G C A+ AL+ +NS ++LP+ Sbjct: 44 PHPSSERRAVYIGALFPMSGGWPGGQACQP-----------AVEMALEDVNSRRDILPDY 92 Query: 100 TLGARILDT-CSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASG 158 L D+ C Q+ ++ L+ D P K++ + G S Sbjct: 93 ELKLIHHDSKCDPG-----QATKYLYELLYND----------------PIKIILMPGCS- 130 Query: 159 SSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGW 218 SVS +VA R++ + +SY S++P LS+ +R+ F R P + V + + GW Sbjct: 131 -SVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 189 Query: 219 NYVSTLASEGSYGEKGVESFTQISKEAG 246 ++T+ ++ + KEAG Sbjct: 190 KKIATIQQTTEVFTSTLDDLEERVKEAG 217 Score = 55.1 bits (131), Expect = 3e-07 Identities = 57/276 (20%), Positives = 114/276 (41%), Gaps = 27/276 (9%) Query: 597 LAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLM------IAKP 650 L+ LGI+ + ++ I + ++ S L+ + G L F + I + Sbjct: 481 LSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRN 540 Query: 651 DVA-VCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSL 709 VC R LGLG + Y ++ TK ++ +F + ++ + + P A L Sbjct: 541 QFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLL 600 Query: 710 ISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICS---------- 759 + + +L + IW VDP + I+ T E+ + + I CS Sbjct: 601 VGMDVLTLAIWQIVDPLHRTIE-----TFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGI 655 Query: 760 -LGYSILLMVTCTVYAIKTRGV-PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEK 817 GY LL++ A +T+ V E N+ + +G +Y ++ L P+ + + Sbjct: 656 FYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDA 715 Query: 818 LYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPE 853 + ++++ S+ + L +L++PK+ +I E Sbjct: 716 AF---AFASLAIVFSSYITLVVLFVPKMRRLITRGE 748 >gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a precursor [Homo sapiens] Length = 961 Score = 55.5 bits (132), Expect = 2e-07 Identities = 53/208 (25%), Positives = 88/208 (42%), Gaps = 37/208 (17%) Query: 40 PHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNV 99 PHS R V +G LFP+ P G C A+ AL+ +NS ++LP+ Sbjct: 163 PHSERRA--VYIGALFPMSGGWPGGQACQP-----------AVEMALEDVNSRRDILPDY 209 Query: 100 TLGARILDT-CSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASG 158 L D+ C Q+ ++ L+ D P K++ + G S Sbjct: 210 ELKLIHHDSKCDPG-----QATKYLYELLYND----------------PIKIILMPGCS- 247 Query: 159 SSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGW 218 SVS +VA R++ + +SY S++P LS+ +R+ F R P + V + + GW Sbjct: 248 -SVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 306 Query: 219 NYVSTLASEGSYGEKGVESFTQISKEAG 246 ++T+ ++ + KEAG Sbjct: 307 KKIATIQQTTEVFTSTLDDLEERVKEAG 334 Score = 55.1 bits (131), Expect = 3e-07 Identities = 57/276 (20%), Positives = 114/276 (41%), Gaps = 27/276 (9%) Query: 597 LAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLM------IAKP 650 L+ LGI+ + ++ I + ++ S L+ + G L F + I + Sbjct: 598 LSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRN 657 Query: 651 DVA-VCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSL 709 VC R LGLG + Y ++ TK ++ +F + ++ + + P A L Sbjct: 658 QFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLL 717 Query: 710 ISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICS---------- 759 + + +L + IW VDP + I+ T E+ + + I CS Sbjct: 718 VGMDVLTLAIWQIVDPLHRTIE-----TFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGI 772 Query: 760 -LGYSILLMVTCTVYAIKTRGV-PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEK 817 GY LL++ A +T+ V E N+ + +G +Y ++ L P+ + + Sbjct: 773 FYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDA 832 Query: 818 LYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPE 853 + ++++ S+ + L +L++PK+ +I E Sbjct: 833 AF---AFASLAIVFSSYITLVVLFVPKMRRLITRGE 865 >gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] Length = 324 Score = 48.9 bits (115), Expect = 2e-05 Identities = 31/96 (32%), Positives = 46/96 (47%), Gaps = 10/96 (10%) Query: 23 VLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHA------KGPSGVPCGDIK--REN 74 ++ C A A E + + GD L GLFP+H+ P C E+ Sbjct: 14 LISCCWAFACHSTE--SSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEH 71 Query: 75 GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCS 110 G H +AM +++IN+ LLPN+TLG ++ D CS Sbjct: 72 GYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCS 107 Score = 47.8 bits (112), Expect = 5e-05 Identities = 40/136 (29%), Positives = 59/136 (43%), Gaps = 11/136 (8%) Query: 448 LLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWT-DELQLNI 506 LL+ I V+F T V FN N D Y+I + N + ++G T +QLNI Sbjct: 167 LLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWDW-NGPKWTFTVLGSSTWSPVQLNI 224 Query: 507 ED--MQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDE----MTC 560 + +QW ++P SVC+ C G ++ CC+ C PC + TC Sbjct: 225 NETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSATWVRTC 284 Query: 561 QHCPYDQRPNENRTGC 576 Q RPN + + C Sbjct: 285 QRT--TTRPNVSPSAC 298 >gi|7706451 G protein-coupled receptor, family C, group 5, member B precursor [Homo sapiens] Length = 403 Score = 44.7 bits (104), Expect = 4e-04 Identities = 53/269 (19%), Positives = 111/269 (41%), Gaps = 42/269 (15%) Query: 590 WAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRE----LSYVLLTGIFLCYIITFL 645 W ++ +A G + T+ +M I P ++ ++ L ++ L G + +TF Sbjct: 55 WGIVVEAVAGAGALITLLLM--LILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFA 112 Query: 646 MIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAP---RLISPTSQ 702 I + D +CS RR G+ + ++ LL++ R+ R+ G T P +L+ Sbjct: 113 FIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHG----TGPAGWQLVGLALC 168 Query: 703 LAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGY 762 L + +I+V+ L + + P C + + +L Y Sbjct: 169 LMLVQVIIAVEWLVLTVLRDTRP----------------------ACAYEPMDFVMALIY 206 Query: 763 SILLMVTCTVYAIKTRGVPENFNEAKPIG----FTMYTTCIVWLAFIPIF-FGTAQSAEK 817 ++L+V A+ T + F K G T + + ++W+A++ ++ FG + + Sbjct: 207 DMVLLVVTLGLALFT--LCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQG 264 Query: 818 LYIQTTTLTISMNLSASVALGMLYMPKVY 846 TL I++ S V + +P+++ Sbjct: 265 DAWNDPTLAITLAASGWVFVIFHAIPEIH 293 >gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] Length = 885 Score = 40.0 bits (92), Expect = 0.010 Identities = 27/147 (18%), Positives = 63/147 (42%), Gaps = 19/147 (12%) Query: 172 FQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYG 231 ++IP + + SD + F R VPP S Q+ ++++ WN++ L S+ G Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173 Query: 232 EKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFD----RIIKQLLDTP--NSRAVVI 285 + + +E + + ++ + FD + L++ +R +++ Sbjct: 174 RAAQKRLETLLEER------------ESKAEKVLQFDPGTKNVTALLMEAKELEARVIIL 221 Query: 286 FANDEDIKQILAAAKRADQVGH-FLWV 311 A+++D + AA + G ++W+ Sbjct: 222 SASEDDAATVYRAAAMLNMTGSGYVWL 248 >gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] Length = 938 Score = 40.0 bits (92), Expect = 0.010 Identities = 27/147 (18%), Positives = 63/147 (42%), Gaps = 19/147 (12%) Query: 172 FQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYG 231 ++IP + + SD + F R VPP S Q+ ++++ WN++ L S+ G Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173 Query: 232 EKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFD----RIIKQLLDTP--NSRAVVI 285 + + +E + + ++ + FD + L++ +R +++ Sbjct: 174 RAAQKRLETLLEER------------ESKAEKVLQFDPGTKNVTALLMEAKELEARVIIL 221 Query: 286 FANDEDIKQILAAAKRADQVGH-FLWV 311 A+++D + AA + G ++W+ Sbjct: 222 SASEDDAATVYRAAAMLNMTGSGYVWL 248 >gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] Length = 901 Score = 40.0 bits (92), Expect = 0.010 Identities = 27/147 (18%), Positives = 63/147 (42%), Gaps = 19/147 (12%) Query: 172 FQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYG 231 ++IP + + SD + F R VPP S Q+ ++++ WN++ L S+ G Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173 Query: 232 EKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFD----RIIKQLLDTP--NSRAVVI 285 + + +E + + ++ + FD + L++ +R +++ Sbjct: 174 RAAQKRLETLLEER------------ESKAEKVLQFDPGTKNVTALLMEAKELEARVIIL 221 Query: 286 FANDEDIKQILAAAKRADQVGH-FLWV 311 A+++D + AA + G ++W+ Sbjct: 222 SASEDDAATVYRAAAMLNMTGSGYVWL 248 >gi|93352554 GPR158-like 1 [Homo sapiens] Length = 2367 Score = 40.0 bits (92), Expect = 0.010 Identities = 66/301 (21%), Positives = 115/301 (38%), Gaps = 34/301 (11%) Query: 558 MTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYND 617 + C CP E T C D +E + + ++A M R Sbjct: 354 LQCLPCP------EGCTSCMDATPCLVEEAAVLRAAVLACQACCMLAIFLSMLVSYRCRR 407 Query: 618 TPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKT 677 + ASG L +L G L Y F++ KP V C R LG I Y ++ K Sbjct: 408 NKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKL 467 Query: 678 NRIYRIFEQGKKSVTAPR-LISPTSQLAITSSLISVQLLG-VFIWF------GVDPPNII 729 R+ ++F S TA R + + +L L+ + +LG + +W G+ ++ Sbjct: 468 YRVLQLF----LSRTAQRSALLSSGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLV 523 Query: 730 IDYDEHKTMNPEQARGVLKC--DITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEA 787 I + R C D D ++ + +LL+ + TR V F+E Sbjct: 524 I------RGHTPSGRHFYLCHHDRWDYIMVVA---ELLLLCWGSFLCYATRAVLSAFHEP 574 Query: 788 KPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASV--ALGMLYMPKV 845 + +G ++ ++ AF F S L+ T L + ++V L ++++PK Sbjct: 575 RYMGIALHNELLLSAAFHTARFVLVPS---LHPDWTLLLFFFHTHSTVTTTLALIFIPKF 631 Query: 846 Y 846 + Sbjct: 632 W 632 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.137 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,346,444 Number of Sequences: 37866 Number of extensions: 1518685 Number of successful extensions: 3323 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 32 Number of HSP's successfully gapped in prelim test: 13 Number of HSP's that attempted gapping in prelim test: 3159 Number of HSP's gapped (non-prelim): 66 length of query: 915 length of database: 18,247,518 effective HSP length: 111 effective length of query: 804 effective length of database: 14,044,392 effective search space: 11291691168 effective search space used: 11291691168 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.