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Search of human proteins with 4504001
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504001 connexin 43 [Homo sapiens]
(382 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504001 connexin 43 [Homo sapiens] 778 0.0
gi|62865885 connexin 37 [Homo sapiens] 303 2e-82
gi|22779877 connexin 46 [Homo sapiens] 300 1e-81
gi|55953076 connexin 50 [Homo sapiens] 270 2e-72
gi|32483412 connexin 40 [Homo sapiens] 267 1e-71
gi|6631083 connexin 40 [Homo sapiens] 267 1e-71
gi|14211941 gap junction protein, alpha 10 [Homo sapiens] 249 4e-66
gi|31542845 gap junction protein, alpha 9, 59kDa [Homo sapiens] 245 4e-65
gi|122939172 connexin 45 [Homo sapiens] 217 1e-56
gi|69122473 connexin 45 [Homo sapiens] 217 1e-56
gi|148233402 gap junction protein, beta 1, 32kDa [Homo sapiens] 207 1e-53
gi|4504005 gap junction protein, beta 1, 32kDa [Homo sapiens] 207 1e-53
gi|42558283 gap junction protein beta 2 [Homo sapiens] 207 2e-53
gi|159032020 gap junction protein, beta 6 [Homo sapiens] 206 2e-53
gi|158966714 gap junction protein, beta 6 [Homo sapiens] 206 2e-53
gi|158966717 gap junction protein, beta 6 [Homo sapiens] 206 2e-53
gi|40254837 gap junction protein, beta 6 [Homo sapiens] 206 2e-53
gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens] 201 9e-52
gi|54607056 connexin 31 [Homo sapiens] 189 5e-48
gi|13128960 connexin 31 [Homo sapiens] 189 5e-48
gi|23397464 gap junction protein, beta 4 [Homo sapiens] 188 6e-48
gi|38348412 gap junction protein, beta 7, 25kDa [Homo sapiens] 184 9e-47
gi|10190698 gap junction protein, delta 2, 36kDa [Homo sapiens] 184 2e-46
gi|10835079 gap junction protein, beta 5, 31.1kDa [Homo sapiens] 181 1e-45
gi|148839378 gap junction protein, delta 3, 31.9kDa [Homo sapiens] 171 8e-43
gi|31559821 gap junction protein, gamma 3, 30.2kDa [Homo sapiens] 136 3e-32
gi|145699105 connexin40.1 [Homo sapiens] 130 3e-30
gi|169171704 PREDICTED: similar to hCG1770601 [Homo sapiens] 86 6e-17
gi|169171845 PREDICTED: similar to hCG1770601 [Homo sapiens] 86 6e-17
gi|169171183 PREDICTED: similar to hCG1770601 [Homo sapiens] 86 6e-17
>gi|4504001 connexin 43 [Homo sapiens]
Length = 382
Score = 778 bits (2009), Expect = 0.0
Identities = 382/382 (100%), Positives = 382/382 (100%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG
Sbjct: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG 120
CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG
Sbjct: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG 120
Query: 121 VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS 180
VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS
Sbjct: 121 VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS 180
Query: 181 LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV 240
LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV
Sbjct: 181 LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV 240
Query: 241 KGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRN 300
KGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRN
Sbjct: 241 KGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRN 300
Query: 301 YNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVD 360
YNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVD
Sbjct: 301 YNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVD 360
Query: 361 QRPSSRASSRASSRPRPDDLEI 382
QRPSSRASSRASSRPRPDDLEI
Sbjct: 361 QRPSSRASSRASSRPRPDDLEI 382
>gi|62865885 connexin 37 [Homo sapiens]
Length = 333
Score = 303 bits (775), Expect = 2e-82
Identities = 157/322 (48%), Positives = 206/322 (63%), Gaps = 29/322 (9%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MGDW L KLLD+VQ +ST GK+WL+VLFIFRIL+LG A ES WGDEQS F CNT QPG
Sbjct: 1 MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG 120
C NVCYD++FPISH+R+WVLQ +FVS PTL+YL HV Y+ R+EE+L +KE EL+
Sbjct: 61 CTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKD 120
Query: 121 VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS 180
V+ L +E + K + E G++++RG L+ TY+ S+L KS+ E FL QW +YG++
Sbjct: 121 PQVERALAAVERQMAKISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWT 180
Query: 181 LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYV----FFKGV 236
+ V+ C+R PCP+ VDCF+SRPTEKTIFIIFMLVV L+SL LN++EL ++ +G+
Sbjct: 181 MEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGM 240
Query: 237 KDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNS 296
+ R + P TS P D Q + Y P SPP
Sbjct: 241 RARQGQDAPPTQGTSS--DPYTD---QVFFYL------PVGQGPSSPP------------ 277
Query: 297 SCRNYN-KQASEQNWANYSAEQ 317
C YN +SEQNWAN + E+
Sbjct: 278 -CPTYNGLSSSEQNWANLTTEE 298
>gi|22779877 connexin 46 [Homo sapiens]
Length = 435
Score = 300 bits (768), Expect = 1e-81
Identities = 175/446 (39%), Positives = 238/446 (53%), Gaps = 75/446 (16%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MGDWS LG+LL+ Q +ST GKVWL+VLFIFRIL+LG A E WGDEQS F CNTQQPG
Sbjct: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG 120
CENVCYD++FPISH+RFW LQIIFVS PTL+YL HV +++R EEK ++EEE ++ +
Sbjct: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
Query: 121 VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS 180
+ + ++ G+V+M G LLRTY+ +I+FK++FEV F+ Q+++YGF
Sbjct: 121 SPKEPPQDNPSSR------DDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFE 174
Query: 181 LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV 240
L +Y C R PCP+ VDCF+SRPTEKTIFIIFML V+ SL LN++E++++ +K +K V
Sbjct: 175 LKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGV 234
Query: 241 K------------GKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGY-- 286
G +DP + PA G Y + APL GY
Sbjct: 235 TSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPY-----YAHTAAPLGQARAVGYPG 289
Query: 287 -----------KLVTGDRNNSSCRNYNKQ----ASEQNWANYSAEQNRMGQAGSTISNSH 331
L S + YN +EQNWAN +AE+ +++
Sbjct: 290 APPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTP 349
Query: 332 AQPFDF-----------------------------------PDDNQNSKKLAAGHELQPL 356
A P P++ + + AA PL
Sbjct: 350 AAPSPVGSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPL 409
Query: 357 AIVDQRPSSRASSRASSRPRPDDLEI 382
+ D +S+AS +S R RP+DL I
Sbjct: 410 PLGDPGRASKASRASSGRARPEDLAI 435
>gi|55953076 connexin 50 [Homo sapiens]
Length = 433
Score = 270 bits (689), Expect = 2e-72
Identities = 133/241 (55%), Positives = 176/241 (73%), Gaps = 4/241 (1%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MGDWS LG +L++V +ST G+VWL+VLFIFRIL+LGTA E WGDEQS F CNTQQPG
Sbjct: 1 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG 120
CENVCYD++FPISH+R WVLQIIFVS P+L+Y+ H + +R EEK +E E ++ Q G
Sbjct: 61 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAE-ELGQQAG 119
Query: 121 VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS 180
N Q +KK G + K ++ G LLRTYI I+FK++FEV F++ +++YGF
Sbjct: 120 TNGGP--DQGSVKK-SSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFR 176
Query: 181 LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV 240
+ +Y C R PCP+ VDCF+SRPTEKTIFI+FML V+ VSL LN++EL ++ KG++ +
Sbjct: 177 ILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSAL 236
Query: 241 K 241
K
Sbjct: 237 K 237
>gi|32483412 connexin 40 [Homo sapiens]
Length = 358
Score = 267 bits (682), Expect = 1e-71
Identities = 160/396 (40%), Positives = 233/396 (58%), Gaps = 52/396 (13%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MGDWS LG L++V +ST GKVWL+VLFIFR+L+LGTA ES+WGDEQ+ FRC+T QPG
Sbjct: 1 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKE-EELKVAQTD 119
C+NVCYD++FPISH+R+WVLQIIFVS P+L+Y+ H + +R +EK +E E K +
Sbjct: 61 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 120
Query: 120 GVNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGF 179
G ++ E+ ++ G +G++ ++G LL TY+ SIL ++ EV F++ Q++IYG
Sbjct: 121 GSYEYPVAEKAELSCWEEG---NGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGI 177
Query: 180 SLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDR 239
L+ ++ C+R PCPH V+C++SRPTEK +FI+FML V+ +SL L++ EL+++ +K ++ R
Sbjct: 178 FLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQR 237
Query: 240 -VKGK--------SDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVT 290
VK + S P + +P D FN C + PG K
Sbjct: 238 FVKPRQHMAKCQLSGPSVGIVQSCTPPPD--------FNQCLE--------NGPGGKFFN 281
Query: 291 GDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGST----ISNSHAQPFDFPDDNQNSKK 346
NN AS+QN N EQ R GQ + I + Q + P+
Sbjct: 282 PFSNN--------MASQQNTDNLVTEQVR-GQEQTPGEGFIQVRYGQKPEVPNG------ 326
Query: 347 LAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI 382
++ GH L D+R S+ASS+A R DDL +
Sbjct: 327 VSPGHRLPHGYHSDKRRLSKASSKA----RSDDLSV 358
>gi|6631083 connexin 40 [Homo sapiens]
Length = 358
Score = 267 bits (682), Expect = 1e-71
Identities = 160/396 (40%), Positives = 233/396 (58%), Gaps = 52/396 (13%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MGDWS LG L++V +ST GKVWL+VLFIFR+L+LGTA ES+WGDEQ+ FRC+T QPG
Sbjct: 1 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKE-EELKVAQTD 119
C+NVCYD++FPISH+R+WVLQIIFVS P+L+Y+ H + +R +EK +E E K +
Sbjct: 61 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 120
Query: 120 GVNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGF 179
G ++ E+ ++ G +G++ ++G LL TY+ SIL ++ EV F++ Q++IYG
Sbjct: 121 GSYEYPVAEKAELSCWEEG---NGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGI 177
Query: 180 SLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDR 239
L+ ++ C+R PCPH V+C++SRPTEK +FI+FML V+ +SL L++ EL+++ +K ++ R
Sbjct: 178 FLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQR 237
Query: 240 -VKGK--------SDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVT 290
VK + S P + +P D FN C + PG K
Sbjct: 238 FVKPRQHMAKCQLSGPSVGIVQSCTPPPD--------FNQCLE--------NGPGGKFFN 281
Query: 291 GDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGST----ISNSHAQPFDFPDDNQNSKK 346
NN AS+QN N EQ R GQ + I + Q + P+
Sbjct: 282 PFSNN--------MASQQNTDNLVTEQVR-GQEQTPGEGFIQVRYGQKPEVPNG------ 326
Query: 347 LAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI 382
++ GH L D+R S+ASS+A R DDL +
Sbjct: 327 VSPGHRLPHGYHSDKRRLSKASSKA----RSDDLSV 358
>gi|14211941 gap junction protein, alpha 10 [Homo sapiens]
Length = 543
Score = 249 bits (635), Expect = 4e-66
Identities = 117/247 (47%), Positives = 176/247 (71%), Gaps = 4/247 (1%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MGDW+ LG +L++V ++ST GK+WL++LFIFR+L+L A E W DEQSAF CNT+QPG
Sbjct: 1 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG 120
C N+CYD +FPIS +RFWVLQIIFVS P+L+Y+ H Y +R EK ++++ AQ +
Sbjct: 61 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN 120
Query: 121 VNVDMHLKQ---IEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY 177
++D+ +Q E+++ + H KV ++G LLRTY++ IL +S+ EV F++ Q+ +Y
Sbjct: 121 PDLDLEEQQRIDRELRRLEEQKRIH-KVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY 179
Query: 178 GFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVK 237
GF + +Y C + PCP+ VDCF+SRPTEKTIF++FM ++ +SL LNI+E+F++ + +
Sbjct: 180 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM 239
Query: 238 DRVKGKS 244
+ KS
Sbjct: 240 RTLYKKS 246
>gi|31542845 gap junction protein, alpha 9, 59kDa [Homo sapiens]
Length = 515
Score = 245 bits (626), Expect = 4e-65
Identities = 139/389 (35%), Positives = 220/389 (56%), Gaps = 29/389 (7%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MGDW+ LG L++V +ST GK+WL++LFIFR+L+LG A E W DEQS F CNT+QPG
Sbjct: 1 MGDWNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMR-KEEKLNKKEEELKVAQTD 119
C NVCYD++FPIS +R+WVLQ+IFVS P+L+Y+ H Y +R EE+ + + +L+V + +
Sbjct: 61 CRNVCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKAQLRV-ELE 119
Query: 120 GVNVDMHLKQIEIKKFKYGIEEH--GKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY 177
V +M + +++ +E+ K +RG LL TY+I I +S+ EV F++ Q+ +Y
Sbjct: 120 EVEFEMPRDRRRLEQELCQLEKRKLNKAPLRGTLLCTYVIHIFTRSVVEVGFMIGQYLLY 179
Query: 178 GFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVK 237
GF L ++ C PCP+ +DCF+SRPTEKTIF++FM ++ +SL LNI+E+F++ FK +K
Sbjct: 180 GFHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIATISLFLNILEIFHLGFKKIK 239
Query: 238 D------RVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTG 291
++K + + +HA Q A + S+ + P +P LV
Sbjct: 240 RGLWGKYKLKKEHNEFHANK---------AKQNVAKYQSTSANSLKRLPSAPDYNLLVEK 290
Query: 292 DRNNSSCRNYNKQASEQ-NWANYSAEQNR---------MGQAGSTISNSHAQPFDFPDDN 341
+ + + N + Q N N+S + + ST+S S + +N
Sbjct: 291 QTHTAVYPSLNSSSVFQPNPDNHSVNDEKCILDEQETVLSNEISTLSTSCSHFQHISSNN 350
Query: 342 QNSKKLAAGHELQPLAIVDQRPSSRASSR 370
G EL ++++R + S+
Sbjct: 351 NKDTHKIFGKELNGNQLMEKRETEGKDSK 379
>gi|122939172 connexin 45 [Homo sapiens]
Length = 396
Score = 217 bits (553), Expect = 1e-56
Identities = 124/338 (36%), Positives = 190/338 (56%), Gaps = 42/338 (12%)
Query: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F CNT+QPGCEN
Sbjct: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
Query: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLN---------------K 108
VCYD P+SHVRFWV QII V+ P+++YL + + + K E K
Sbjct: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
Query: 109 KEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYIISIL 160
+ L+ + D M ++E++ K E+ G+ ++R GL++ Y++ +L
Sbjct: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
Query: 161 FKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVS 220
+++FEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+ +
Sbjct: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
Query: 221 LALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSP 280
L LNI E+ ++ F ++D + K +D G+ Y P +P
Sbjct: 243 LLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTWNTP 284
Query: 281 MSPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 317
+PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 285 SAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
>gi|69122473 connexin 45 [Homo sapiens]
Length = 396
Score = 217 bits (553), Expect = 1e-56
Identities = 124/338 (36%), Positives = 190/338 (56%), Gaps = 42/338 (12%)
Query: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
WS L +LL+++ +ST GK+WL+VL +FRI+L ES + DEQS F CNT+QPGCEN
Sbjct: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
Query: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLN---------------K 108
VCYD P+SHVRFWV QII V+ P+++YL + + + K E K
Sbjct: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
Query: 109 KEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEE-------HGKVKMR-GGLLRTYIISIL 160
+ L+ + D M ++E++ K E+ G+ ++R GL++ Y++ +L
Sbjct: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLL 182
Query: 161 FKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVS 220
+++FEV FL+ Q+++YGF + Y C R PCPH++DCF+SRPTEKTIF++ M V+ +
Sbjct: 183 ARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLC 242
Query: 221 LALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSP 280
L LNI E+ ++ F ++D + K +D G+ Y P +P
Sbjct: 243 LLLNIWEMLHLGFGTIRDSLNSKR----------RELEDPGAYNY--------PFTWNTP 284
Query: 281 MSPPGYKL-VTGDRNNSSCRNYNKQASEQNWANYSAEQ 317
+PPGY + V D+ + + K A +QN AN + EQ
Sbjct: 285 SAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQ 322
>gi|148233402 gap junction protein, beta 1, 32kDa [Homo sapiens]
Length = 283
Score = 207 bits (528), Expect = 1e-53
Identities = 105/245 (42%), Positives = 153/245 (62%), Gaps = 20/245 (8%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
+W+ L LL V +STA G+VWLSV+FIFRI++L A ES WGDE+S+F CNT QPGC
Sbjct: 2 NWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCN 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
+VCYD+ FPISHVR W LQ+I VS P LL HV + E+K+ + E G
Sbjct: 62 SVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLE---------GHG 112
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
+HL+++ + KV + G L TY+IS++F+ +FE F+ + + +Y G+++
Sbjct: 113 DPLHLEEV----------KRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAM 162
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVK 241
+ C PCP+ VDCF+SRPTEKT+F +FML S + + LN+ E+ Y+ + R +
Sbjct: 163 VRLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQ 222
Query: 242 GKSDP 246
+S+P
Sbjct: 223 RRSNP 227
>gi|4504005 gap junction protein, beta 1, 32kDa [Homo sapiens]
Length = 283
Score = 207 bits (528), Expect = 1e-53
Identities = 105/245 (42%), Positives = 153/245 (62%), Gaps = 20/245 (8%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
+W+ L LL V +STA G+VWLSV+FIFRI++L A ES WGDE+S+F CNT QPGC
Sbjct: 2 NWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCN 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
+VCYD+ FPISHVR W LQ+I VS P LL HV + E+K+ + E G
Sbjct: 62 SVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLE---------GHG 112
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
+HL+++ + KV + G L TY+IS++F+ +FE F+ + + +Y G+++
Sbjct: 113 DPLHLEEV----------KRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAM 162
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVK 241
+ C PCP+ VDCF+SRPTEKT+F +FML S + + LN+ E+ Y+ + R +
Sbjct: 163 VRLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQ 222
Query: 242 GKSDP 246
+S+P
Sbjct: 223 RRSNP 227
>gi|42558283 gap junction protein beta 2 [Homo sapiens]
Length = 226
Score = 207 bits (526), Expect = 2e-53
Identities = 109/233 (46%), Positives = 144/233 (61%), Gaps = 19/233 (8%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
DW L +L V +ST+ GK+WL+VLFIFRI++L A + WGDEQ+ F CNT QPGC+
Sbjct: 2 DWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCK 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVCYD FPISH+R W LQ+IFVS P LL HV Y R E+K + E+K
Sbjct: 62 NVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAY-RRHEKKRKFIKGEIK-------- 112
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
K IE K + KV++ G L TY SI F+ IFE AF+ + + +Y GFS+
Sbjct: 113 --SEFKDIEEIKTQ-------KVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSM 163
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFK 234
+ C PCP+ VDCF+SRPTEKT+F +FM+ VS + + LN+ EL Y+ +
Sbjct: 164 QRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIR 216
>gi|159032020 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 206 bits (525), Expect = 2e-53
Identities = 109/252 (43%), Positives = 152/252 (60%), Gaps = 23/252 (9%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
DW L + V +ST+ GKVW++V+FIFR+++L A + WGDEQ F CNT QPGC+
Sbjct: 2 DWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCK 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVCYD FP+SH+R W LQ+IFVS P LL HV Y + + ++ E+ + D +
Sbjct: 62 NVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEK----RNDFKD 117
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
++ +IKK KV++ G L TY SI F+ IFE AF+ + +++Y G+ L
Sbjct: 118 IE------DIKK--------QKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHL 163
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFY----VFFKGVK 237
V C DPCP+ VDCF+SRPTEKT+F IFM+ S++ + LN+ EL Y V F+ K
Sbjct: 164 PWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSK 223
Query: 238 DRVKGKSDPYHA 249
K+ P HA
Sbjct: 224 RAQTQKNHPNHA 235
>gi|158966714 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 206 bits (525), Expect = 2e-53
Identities = 109/252 (43%), Positives = 152/252 (60%), Gaps = 23/252 (9%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
DW L + V +ST+ GKVW++V+FIFR+++L A + WGDEQ F CNT QPGC+
Sbjct: 2 DWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCK 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVCYD FP+SH+R W LQ+IFVS P LL HV Y + + ++ E+ + D +
Sbjct: 62 NVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEK----RNDFKD 117
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
++ +IKK KV++ G L TY SI F+ IFE AF+ + +++Y G+ L
Sbjct: 118 IE------DIKK--------QKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHL 163
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFY----VFFKGVK 237
V C DPCP+ VDCF+SRPTEKT+F IFM+ S++ + LN+ EL Y V F+ K
Sbjct: 164 PWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSK 223
Query: 238 DRVKGKSDPYHA 249
K+ P HA
Sbjct: 224 RAQTQKNHPNHA 235
>gi|158966717 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 206 bits (525), Expect = 2e-53
Identities = 109/252 (43%), Positives = 152/252 (60%), Gaps = 23/252 (9%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
DW L + V +ST+ GKVW++V+FIFR+++L A + WGDEQ F CNT QPGC+
Sbjct: 2 DWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCK 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVCYD FP+SH+R W LQ+IFVS P LL HV Y + + ++ E+ + D +
Sbjct: 62 NVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEK----RNDFKD 117
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
++ +IKK KV++ G L TY SI F+ IFE AF+ + +++Y G+ L
Sbjct: 118 IE------DIKK--------QKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHL 163
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFY----VFFKGVK 237
V C DPCP+ VDCF+SRPTEKT+F IFM+ S++ + LN+ EL Y V F+ K
Sbjct: 164 PWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSK 223
Query: 238 DRVKGKSDPYHA 249
K+ P HA
Sbjct: 224 RAQTQKNHPNHA 235
>gi|40254837 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 206 bits (525), Expect = 2e-53
Identities = 109/252 (43%), Positives = 152/252 (60%), Gaps = 23/252 (9%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
DW L + V +ST+ GKVW++V+FIFR+++L A + WGDEQ F CNT QPGC+
Sbjct: 2 DWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCK 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVCYD FP+SH+R W LQ+IFVS P LL HV Y + + ++ E+ + D +
Sbjct: 62 NVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEK----RNDFKD 117
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
++ +IKK KV++ G L TY SI F+ IFE AF+ + +++Y G+ L
Sbjct: 118 IE------DIKK--------QKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHL 163
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFY----VFFKGVK 237
V C DPCP+ VDCF+SRPTEKT+F IFM+ S++ + LN+ EL Y V F+ K
Sbjct: 164 PWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSK 223
Query: 238 DRVKGKSDPYHA 249
K+ P HA
Sbjct: 224 RAQTQKNHPNHA 235
>gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens]
Length = 439
Score = 201 bits (511), Expect = 9e-52
Identities = 122/377 (32%), Positives = 184/377 (48%), Gaps = 76/377 (20%)
Query: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
WS L +LL+++ +ST GKVWL+VL +FRI+L E+ + DEQ+ F CNT+QPGC+N
Sbjct: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
Query: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEK------------------ 105
VCYD P+SHVRFWV QI+ +S P+++YL + + + + +
Sbjct: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPR 125
Query: 106 ------------------------LNKKEEELKVAQTDGVNVDMHLKQIEIKKFKYGIEE 141
L ++EEE + +G + E K +
Sbjct: 126 AHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTK-AVGA 184
Query: 142 HGKVK---------------MRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAVYT 186
GK R GL+R Y+ ++ ++ FEVAFL+ Q+ +YGF + +
Sbjct: 185 DGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFP 244
Query: 187 CKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDP 246
C R PCPH VDCF+SRPTEKT+F++ M VVS + L LN+ E+ ++ +D V+G+ P
Sbjct: 245 CSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGP 304
Query: 247 YHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQAS 306
A++ A +P C+ P A PP Y LV + +A
Sbjct: 305 -PASAPAPAPRPP----------PCAFPAAAAGLACPPDYSLVVRAAERA-------RAH 346
Query: 307 EQNWANYSAEQNRMGQA 323
+QN AN + + R G A
Sbjct: 347 DQNLANLALQALRDGAA 363
>gi|54607056 connexin 31 [Homo sapiens]
Length = 270
Score = 189 bits (479), Expect = 5e-48
Identities = 105/258 (40%), Positives = 140/258 (54%), Gaps = 30/258 (11%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
DW L LL V YSTA G++WLSV+F+FR+L+ A E WGDEQ F CNT+QPGC
Sbjct: 2 DWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCT 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVCYD FPIS++R W LQ+IFV+ P+LL + HV Y +E + +K + D
Sbjct: 62 NVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCAKLYDNAG 121
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFL-LIQWYIYGFSL 181
K GGL TY+ S++FK I E FL L+ +GF++
Sbjct: 122 -----------------------KKHGGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNM 158
Query: 182 SAVYTCKR-DPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGV---- 236
+ C PCP+ VDC+++RPTEK IF FM+ S V + L I EL Y+ V
Sbjct: 159 PRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGASAVCIVLTICELCYLICHRVLRGL 218
Query: 237 -KDRVKGKSDPYHATSGA 253
KD+ +G P + S A
Sbjct: 219 HKDKPRGGCSPSSSASRA 236
>gi|13128960 connexin 31 [Homo sapiens]
Length = 270
Score = 189 bits (479), Expect = 5e-48
Identities = 105/258 (40%), Positives = 140/258 (54%), Gaps = 30/258 (11%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
DW L LL V YSTA G++WLSV+F+FR+L+ A E WGDEQ F CNT+QPGC
Sbjct: 2 DWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCT 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVCYD FPIS++R W LQ+IFV+ P+LL + HV Y +E + +K + D
Sbjct: 62 NVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCAKLYDNAG 121
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFL-LIQWYIYGFSL 181
K GGL TY+ S++FK I E FL L+ +GF++
Sbjct: 122 -----------------------KKHGGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNM 158
Query: 182 SAVYTCKR-DPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGV---- 236
+ C PCP+ VDC+++RPTEK IF FM+ S V + L I EL Y+ V
Sbjct: 159 PRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGASAVCIVLTICELCYLICHRVLRGL 218
Query: 237 -KDRVKGKSDPYHATSGA 253
KD+ +G P + S A
Sbjct: 219 HKDKPRGGCSPSSSASRA 236
>gi|23397464 gap junction protein, beta 4 [Homo sapiens]
Length = 266
Score = 188 bits (478), Expect = 6e-48
Identities = 95/233 (40%), Positives = 134/233 (57%), Gaps = 24/233 (10%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
+W+ L LL V YST ++WLSV+FIFR+L+ A E W DEQ F CNT+QPGC
Sbjct: 2 NWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCP 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVCYD+ FP+SHVR W LQ+I V+ P+LL + HV Y +E K + K + D ++
Sbjct: 62 NVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHHLKHGPNAPSLYDNLS 121
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
K RGGL TY++S++FK+ + FL I +Y + +
Sbjct: 122 -----------------------KKRGGLWWTYLLSLIFKAAVDAGFLYIFHRLYKDYDM 158
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFK 234
V C +PCPH VDC++SRPTEK +F FM+ + + + LN+ E+FY+ K
Sbjct: 159 PRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGK 211
>gi|38348412 gap junction protein, beta 7, 25kDa [Homo sapiens]
Length = 223
Score = 184 bits (468), Expect = 9e-47
Identities = 95/232 (40%), Positives = 136/232 (58%), Gaps = 31/232 (13%)
Query: 4 WSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCEN 63
W L LL V YST G +WL+V+F+FR+L+ A E W DEQ F CN++QPGC+N
Sbjct: 3 WMFLRDLLSGVNKYSTGTGWIWLAVVFVFRLLVYMVAAEHVWKDEQKEFECNSRQPGCKN 62
Query: 64 VCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNV 123
VC+D FPIS VR W LQ+I VS P+LL + HV Y +E++
Sbjct: 63 VCFDDFFPISQVRLWALQLIMVSTPSLLVVLHVAYHEGREKR------------------ 104
Query: 124 DMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSLS 182
H K++ + M GGL Y+IS++ K+ FE+ FL++ + +Y GFS+
Sbjct: 105 --HRKKLYV----------SPGTMDGGLWYAYLISLIVKTGFEIGFLVLFYKLYDGFSVP 152
Query: 183 AVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFK 234
+ C PCP+ VDCF+S+PTEKTIFI+F+++ S + + LN IEL ++ K
Sbjct: 153 YLIKCDLKPCPNTVDCFISKPTEKTIFILFLVITSCLCIVLNFIELSFLVLK 204
>gi|10190698 gap junction protein, delta 2, 36kDa [Homo sapiens]
Length = 321
Score = 184 bits (466), Expect = 2e-46
Identities = 100/286 (34%), Positives = 167/286 (58%), Gaps = 44/286 (15%)
Query: 1 MGDWSALGKLLDK-VQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQP 59
MG+W+ L +LL+ VQ +ST G++ L+V+ IFRIL++ E+ + DEQ+ F CNT QP
Sbjct: 1 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP 60
Query: 60 GCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKL------------- 106
GC CYD++FPISH+R+WV QII V P+L ++ + + K+ +
Sbjct: 61 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP 120
Query: 107 ------------------NKKEEELKVAQTDGV--NVDMHLKQ-----IEIKKF---KYG 138
+++++L+ A +GV N + K+ +E+K+ G
Sbjct: 121 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG 180
Query: 139 IEEHGKVKMR--GGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQV 196
+ K K+R G+ R YII ++F++ E+ FL+ Q+++YGFS+ +Y C R PC +V
Sbjct: 181 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV 240
Query: 197 DCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKG 242
+C++SRPTEKT+F++FM VS + + LN+ EL ++ ++ +K V+G
Sbjct: 241 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAVRG 286
>gi|10835079 gap junction protein, beta 5, 31.1kDa [Homo sapiens]
Length = 273
Score = 181 bits (458), Expect = 1e-45
Identities = 93/233 (39%), Positives = 134/233 (57%), Gaps = 24/233 (10%)
Query: 3 DWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCE 62
+WS LL V YSTA G++WLS++FIFR+L+ E W D+ F CNT+QPGC
Sbjct: 2 NWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCS 61
Query: 63 NVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVN 122
NVC+D+ FP+SHVR W LQ+I V+ P+LL + HV Y ++ +E + + G N
Sbjct: 62 NVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAY---------REVQEKRHREAHGEN 112
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY-GFSL 181
G K RGGL TY+ S++FK+ ++AFL + Y + L
Sbjct: 113 --------------SGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYIL 158
Query: 182 SAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFK 234
V C DPCP+ VDCF+S+P+EK IF +FM+ + + + LN++EL Y+ K
Sbjct: 159 PPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSK 211
>gi|148839378 gap junction protein, delta 3, 31.9kDa [Homo sapiens]
Length = 294
Score = 171 bits (434), Expect = 8e-43
Identities = 86/235 (36%), Positives = 130/235 (55%), Gaps = 19/235 (8%)
Query: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
MG+W+ LG LLD VQ S G++WL V+ IFRIL+L T + + DEQ F CNT QPG
Sbjct: 1 MGEWAFLGSLLDAVQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQPG 60
Query: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG 120
C CYD++FP+SH RFW+ I+ +S P +L++ + + KE + + +
Sbjct: 61 CRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMHRAGKEAGGAEAAAQCAPGLPEA 120
Query: 121 VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS 180
L+ + R Y++S+ + + E+ FL Q +YGF
Sbjct: 121 QCAPCALRARRAR-------------------RCYLLSVALRLLAELTFLGGQALLYGFR 161
Query: 181 LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKG 235
++ + C PCPH VDCF+SRPTEKT+F++F V L+S L++ EL ++ +KG
Sbjct: 162 VAPHFACAGPPCPHTVDCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKG 216
>gi|31559821 gap junction protein, gamma 3, 30.2kDa [Homo sapiens]
Length = 279
Score = 136 bits (343), Expect = 3e-32
Identities = 82/224 (36%), Positives = 121/224 (54%), Gaps = 21/224 (9%)
Query: 7 LGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCY 66
L +LL + ST G++ L VL FR++LL + +GDEQS F C+TQQPGC+ C+
Sbjct: 6 LRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACF 65
Query: 67 DKSFPISHVRFWVLQIIFVSVPTLLYLAHVFY--VMRKEEKLNKKEEELKVAQTDGVNVD 124
D P+S +RFWV Q+I V+VP+ LY+ Y + E KEEE + +G N D
Sbjct: 66 DAFHPLSPLRFWVFQVILVAVPSALYMGFTLYHVIWHWELSGKGKEEETLIQGREG-NTD 124
Query: 125 MHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAV 184
+ G +R LL Y+ + + + E A L +Q+++YGF + +
Sbjct: 125 V----------------PGAGSLR--LLWAYVAQLGARLVLEGAALGLQYHLYGFQMPSS 166
Query: 185 YTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIEL 228
+ C+R+PC + C LSRP+EKTIF+ M VS L +EL
Sbjct: 167 FACRREPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLEL 210
>gi|145699105 connexin40.1 [Homo sapiens]
Length = 370
Score = 130 bits (326), Expect = 3e-30
Identities = 100/378 (26%), Positives = 162/378 (42%), Gaps = 38/378 (10%)
Query: 7 LGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCY 66
LG L+ + T GK+W + + R+L++ A + DEQ F CNT QPGC NVCY
Sbjct: 7 LGFLIITLNCNVTMVGKLWFVLTMLLRMLVIVLAGRPVYQDEQERFVCNTLQPGCANVCY 66
Query: 67 DKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKE----EELKVAQTDGVN 122
D P+SH+RFW++Q + V +P+ ++ +V + L + E Q
Sbjct: 67 DVFSPVSHLRFWLIQGVCVLLPSAVFSVYVLHRGATLAALGPRRCPDPREPASGQRRCPR 126
Query: 123 VDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLS 182
+++ F G YII +L +++ E AF + ++++GF
Sbjct: 127 PFGERGGLQVPDFSAG----------------YIIHLLLRTLLEAAFGALHYFLFGFLAP 170
Query: 183 AVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKG 242
+ C R PC VDC++SRPTEK++ ++F+ VS +S L + +L + ++ R
Sbjct: 171 KKFPCTRPPCTGVVDCYVSRPTEKSLLMLFLWAVSALSFLLGLADLVCSLRRRMRRRPGP 230
Query: 243 KSDP-YHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNY 301
+ P SGA A+ ++ G AP P + G + R S +
Sbjct: 231 PTSPSIRKQSGASGHAE---GRRTDEEGGREEEGAPAPPGARAGGEGAGSPRRTSRVSGH 287
Query: 302 NKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVDQ 361
K E S+ ++G+ QP P +G E QP A
Sbjct: 288 TKIPDEDESEVTSSASEKLGR----------QPRGRPHREAAQDPRGSGSEEQPSA---- 333
Query: 362 RPSSRASSRASSRPRPDD 379
PS A+ + S +P D
Sbjct: 334 APSRLAAPPSCSSLQPPD 351
>gi|169171704 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 85.9 bits (211), Expect = 6e-17
Identities = 39/86 (45%), Positives = 58/86 (67%)
Query: 10 LLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKS 69
LL + +ST G++ VL FR++LL + +GDEQS F C+TQQPGC+ C+D
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 70 FPISHVRFWVLQIIFVSVPTLLYLAH 95
P+S +RFWV Q+I V+VP++LY+ +
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
>gi|169171845 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 85.9 bits (211), Expect = 6e-17
Identities = 39/86 (45%), Positives = 58/86 (67%)
Query: 10 LLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKS 69
LL + +ST G++ VL FR++LL + +GDEQS F C+TQQPGC+ C+D
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 70 FPISHVRFWVLQIIFVSVPTLLYLAH 95
P+S +RFWV Q+I V+VP++LY+ +
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
>gi|169171183 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 85.9 bits (211), Expect = 6e-17
Identities = 39/86 (45%), Positives = 58/86 (67%)
Query: 10 LLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKS 69
LL + +ST G++ VL FR++LL + +GDEQS F C+TQQPGC+ C+D
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 70 FPISHVRFWVLQIIFVSVPTLLYLAH 95
P+S +RFWV Q+I V+VP++LY+ +
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,995,115
Number of Sequences: 37866
Number of extensions: 662059
Number of successful extensions: 2321
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2234
Number of HSP's gapped (non-prelim): 71
length of query: 382
length of database: 18,247,518
effective HSP length: 104
effective length of query: 278
effective length of database: 14,309,454
effective search space: 3978028212
effective search space used: 3978028212
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.