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Search of human proteins with 4503917
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503917 growth arrest-specific 8 [Homo sapiens]
(478 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503917 growth arrest-specific 8 [Homo sapiens] 932 0.0
gi|31982906 cingulin-like 1 [Homo sapiens] 84 2e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 80 5e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 80 5e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 80 5e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 80 5e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 80 5e-15
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 79 9e-15
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 79 9e-15
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 79 1e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 78 2e-14
gi|148746195 trichohyalin [Homo sapiens] 78 2e-14
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 77 3e-14
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 77 3e-14
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 77 3e-14
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 77 3e-14
gi|71061468 centromere protein E [Homo sapiens] 77 4e-14
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 76 8e-14
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 75 1e-13
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 75 1e-13
gi|16262452 cingulin [Homo sapiens] 75 2e-13
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 74 3e-13
gi|42794779 myosin 18A isoform b [Homo sapiens] 74 3e-13
gi|28416946 myosin 18A isoform a [Homo sapiens] 74 3e-13
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 74 3e-13
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 74 4e-13
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 74 4e-13
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 74 4e-13
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 74 4e-13
gi|109134347 NY-REN-58 antigen [Homo sapiens] 74 4e-13
>gi|4503917 growth arrest-specific 8 [Homo sapiens]
Length = 478
Score = 932 bits (2409), Expect = 0.0
Identities = 478/478 (100%), Positives = 478/478 (100%)
Query: 1 MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIH 60
MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIH
Sbjct: 1 MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIH 60
Query: 61 TFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEG 120
TFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEG
Sbjct: 61 TFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEG 120
Query: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER
Sbjct: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
Query: 181 QVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDI 240
QVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDI
Sbjct: 181 QVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDI 240
Query: 241 TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 300
TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY
Sbjct: 241 TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 300
Query: 301 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKT 360
ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKT
Sbjct: 301 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKT 360
Query: 361 GFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL 420
GFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL
Sbjct: 361 GFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL 420
Query: 421 QYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGTPT 478
QYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGTPT
Sbjct: 421 QYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGTPT 478
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 84.3 bits (207), Expect = 2e-16
Identities = 99/438 (22%), Positives = 198/438 (45%), Gaps = 58/438 (13%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDRE 83
E +++ ++E R+R L+ R + N E + +++LEE + ELR E
Sbjct: 633 EVKNQQNIKEERERMRANLEELRSQHNEKVEENSTL-------QQRLEESEGELRKNLEE 685
Query: 84 MEEAE---ERHQVEIKVYKQKVKHLLYEHQN-NLTEMKAEGTVVMKLAQKEHRIQ----- 134
+ + + E+HQ EI+ + ++ + E + +E + +G ++ +L Q + +Q
Sbjct: 686 LFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745
Query: 135 ----ESVLRK---DMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIE- 186
E +LRK ++ ALK LKE+ + + + L+ ++ E+ +R E + +E
Sbjct: 746 KEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEV 805
Query: 187 ------------AKYDKKMKMLRDELD--LRRKTELHEVEERKNGQIHTLMQRHEEAFTD 232
A + ++K+L++E + R EL + QI L +A
Sbjct: 806 LASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKET 865
Query: 233 IKNYYNDITLNNLALINSLKEQMEDM---RKKEDHLER---EMAEVSGQNKRLADPLQKA 286
+K Y +I AL+++ KE+ E + R E+ LE +++ + + K+L++ L++
Sbjct: 866 LKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEE 925
Query: 287 REEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELY 346
E+ ++++ E ++ L T +L +KE+ D+ E ++Q + DE
Sbjct: 926 SEQKEQLRRLKNEMENERWHLGKTIEKL---QKEMADIV---EASRTSTLELQNQLDEYK 979
Query: 347 RKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKL 406
K + E+Q++ K LE + L+A + E++ E L R+L
Sbjct: 980 EKNRRELAEMQRQ--LKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL 1037
Query: 407 EDVLESKNSTIKDLQYEL 424
+ T+KDL+YEL
Sbjct: 1038 LE------QTLKDLEYEL 1049
Score = 70.5 bits (171), Expect = 3e-12
Identities = 93/469 (19%), Positives = 192/469 (40%), Gaps = 76/469 (16%)
Query: 25 DMSKEQVEEHVSRIREELDREREERNYFQL-----ERDKIHTFWEITRRQLEEKKAELRN 79
D KEQ + + +RE ++ + E+D+ T + Q E +K + R+
Sbjct: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
Query: 80 KDREMEEAEERHQVE-IKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVL 138
++ E A+ + Q+E +K + K K L +++ + +++ E V + +KE L
Sbjct: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE-EALVHARKEEKEAVSARRAL 897
Query: 139 RKDMRALKVEL----KEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMK 194
++ A + L +EQ+ SE + + K E++ R++N+ E + + +K K
Sbjct: 898 ENELEAAQGNLSQTTQEQKQLSEKLKEESEQK--EQLRRLKNEMENERWHLGKTIEKLQK 955
Query: 195 MLRDELDLRR------KTELHEVEERKNGQIHTL------------------------MQ 224
+ D ++ R + +L E +E+ ++ + M+
Sbjct: 956 EMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMR 1015
Query: 225 RHEEAFTDIKNYYNDITLNNLALINSLKEQ-----------------MEDMRKKEDHLER 267
EE D + ++ L +LK+ ++ M K LE
Sbjct: 1016 LMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEM 1075
Query: 268 EMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWE 327
E+ E + L++ + ++RE+M +++ +L +Q L C K L E++ KDL+
Sbjct: 1076 ELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISL---ERQNKDLKSR 1132
Query: 328 HEVLEQRFTKVQQERDELYRKFTAAIQEVQQK----------TGFKNLVLERKLQALSAA 377
LE + + ++ L + A I E++ + N LERK++ L
Sbjct: 1133 IIHLEGSY---RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQ 1189
Query: 378 VEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQ 426
V+ + + + +L A+ + E+ ++ S+ K LQ EL +
Sbjct: 1190 VDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE 1238
Score = 46.2 bits (108), Expect = 7e-05
Identities = 56/290 (19%), Positives = 130/290 (44%), Gaps = 24/290 (8%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
+ Q++E+ + R EL + + LE +K + ++ + ELR+ R +EA
Sbjct: 972 QNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEA 1031
Query: 88 EERHQVEIKVYKQKVKHLLYEHQ--NNLTEMKAEGTVVM--KLAQKEHRIQESVLRKDMR 143
+ Q+ +Q +K L YE + ++L + ++ M K++Q E ++E D+
Sbjct: 1032 LTKRQL----LEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLL 1087
Query: 144 ALKVELKEQE---LASEVVVKNLRLKHTE----EITRMRNDFERQVREIEAKY--DKKMK 194
+ ++ ++ L +E++ + + E + R D + ++ +E Y K+
Sbjct: 1088 SERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGL 1147
Query: 195 MLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLN------NLAL- 247
+++ E + + E EER + +R E ++ +D L+ L+L
Sbjct: 1148 VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLR 1207
Query: 248 INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQL 297
+ ++K Q+E+ ++ D LE ++ + + D + + +++ M+K L
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
Score = 40.8 bits (94), Expect = 0.003
Identities = 49/250 (19%), Positives = 103/250 (41%), Gaps = 22/250 (8%)
Query: 217 GQIHTLMQRHEEAFTDIKNYY--------NDITLNNLALINSLKEQMEDMRKKEDHLERE 268
GQ Q +EE I Y +D T + L+ + ++ +
Sbjct: 542 GQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQ 601
Query: 269 MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK----DL 324
+ + K L + K E++E+Q+QL +++Q + + R++ +EL+ +
Sbjct: 602 ACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEK 661
Query: 325 QWEHEVLEQRFTKVQQE-RDELYRKFTAAIQEVQQKTGFKNL-----VLERKLQALSAAV 378
E+ L+QR + + E R L F ++ Q +T ++L + +L + +
Sbjct: 662 VEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721
Query: 379 EKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHND----L 434
++++ E L + D L + + ED+L + + L+ L + +H+ L
Sbjct: 722 DREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL 781
Query: 435 LRTYEAKLLA 444
Y+A+L A
Sbjct: 782 KEQYDAELQA 791
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 79.7 bits (195), Expect = 5e-15
Identities = 104/466 (22%), Positives = 205/466 (43%), Gaps = 81/466 (17%)
Query: 25 DMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFW----EITRRQLEEK---KAEL 77
+ +K ++++ + + +LD +R+ + + ++ K I+ R EE+ +AE
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 78 RNKD-------REMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKE 130
R K+ R +EEA E + ++++ K L + ++ ++ G V +L + +
Sbjct: 1479 REKETKALSLARALEEALEAKEE----FERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534
Query: 131 HRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYD 190
+++ V ++MR EL+++ A+E + +L+ + M+ FER ++ + + +
Sbjct: 1535 RALEQQV--EEMRTQLEELEDELQATE----DAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 191 KKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL--- 247
+K ++L ++ R+ E +ERK + ++ E D+K+ I N A
Sbjct: 1589 EKKRLLIKQV---RELEAELEDERKQRALAVASKKKMEI--DLKDLEAQIEAANKARDEV 1643
Query: 248 ---INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYER-- 302
+ L+ QM+D +++ + E+ Q+K L+ E+ ++Q++LA+ ER
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703
Query: 303 -------------------DKQILLCTKARLKVR----EKELKDLQWEHEVLEQRFTKVQ 339
K LL K RL+ R E+EL++ Q E+L RF K
Sbjct: 1704 RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 340 QERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAAL 399
+ D L + AA + QK+ LER+ + L A +++ E
Sbjct: 1764 LQVDTLNAEL-AAERSAAQKSDNARQQLERQNKELKAKLQELE----------------- 1805
Query: 400 TLVSRKLEDVLESKNSTIKDLQYELAQVCK---AHNDLLRTYEAKL 442
V K + + + + I L+ +L Q K A N L+R E KL
Sbjct: 1806 GAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKL 1851
Score = 77.4 bits (189), Expect = 3e-14
Identities = 106/483 (21%), Positives = 203/483 (42%), Gaps = 77/483 (15%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLER-----------DKIHTFWEITRRQLEEKK-- 74
K++++ H+ + E+LD E R QLE+ ++I + + ++EKK
Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004
Query: 75 ---------------------AELRNKDR----EMEEA---EERHQVEIKVYKQKVKHLL 106
A++RNK ++EE EE+ + E++ K+K+
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 107 YEHQNNLTEMKAE-GTVVMKLAQKEHRIQESVLRKD------MRALKVELKEQELASEVV 159
+ Q+ + E++A+ + ++LA+KE +Q ++ R D ALKV + Q +E+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124
Query: 160 VKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQI 219
+ E RN E+Q R++ + + L D LD + E+ ++ ++
Sbjct: 1125 ------EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ--ELRTKREQEV 1176
Query: 220 HTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRL 279
L + EE + + D+ + + L EQ+E ++ + +LE+ + NK L
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236
Query: 280 A---DPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVR--------EKELKDLQWEH 328
A LQ+ + E +K+L ++ + RL+V + EL ++
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 329 EVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEV 388
E E++ K ++ L + + +Q++T K + R Q +E Q E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 389 LAASNLDPAALTLVS------RKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKL 442
A NL+ L L S +K++D L TI+ L+ ++ K L + E K
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDL----GTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 443 LAF 445
LA+
Sbjct: 1413 LAY 1415
Score = 65.9 bits (159), Expect = 8e-11
Identities = 95/465 (20%), Positives = 193/465 (41%), Gaps = 81/465 (17%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
K+++EE + + ++ E E Q E+ K+ + QL+E++ + E A
Sbjct: 917 KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTA 976
Query: 88 EERHQVEIKVYKQKVKHLLYEHQNN--LTEMKAEGTVV----MKLAQKEHRIQESVLRKD 141
E K+ K + + LL E QN+ + E K + +LA++E + + ++
Sbjct: 977 ------EAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 142 MRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDK-KMKMLRDEL 200
+ + + E+ L E + K ++ D + Q+ E++A+ D+ K+++ + E
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090
Query: 201 DLR-----------RKTELHEVEERKNGQIHTLMQRHE-----------------EAFTD 232
+L+ K +V QI L + E E
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 233 IKNYYNDITLNNLALINSLK----EQMEDMRKK-EDHLEREMAEVSGQNKRLADPLQKAR 287
+K D TL+ A L+ +++ +++K E+ + A++ +R A L++
Sbjct: 1151 LKTELED-TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELS 1209
Query: 288 EEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYR 347
E++ + ++ AN E++KQ L E + K+L E +VL+Q V+ E + +
Sbjct: 1210 EQLEQAKRFKANLEKNKQGL----------ETDNKELACEVKVLQQ----VKAESEHKRK 1255
Query: 348 KFTAAIQEVQQKT----------GFKNLVLERKLQALSAAV---EKKEVQFNEVLAASNL 394
K A +QE+ K K L+ +L +S + EKK ++F +
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK------- 1308
Query: 395 DPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYE 439
D A+L + +++L+ + +L + Q+ + N L E
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353
Score = 63.9 bits (154), Expect = 3e-10
Identities = 94/455 (20%), Positives = 189/455 (41%), Gaps = 76/455 (16%)
Query: 6 KGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDR-----EREERNYFQLERDKI- 59
K KK A+ + ++ D + ++ E S+++ ELD E E+ + +D
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312
Query: 60 ---------HTFWEITR---------RQLEEKKAELRNKDREMEEAEERHQVEIKVYKQK 101
E TR RQLEE+K L+ + E EEA + + ++ + +
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372
Query: 102 VKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVK 161
+ + ++L +++ KL + + + + K + K+E + L E+
Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL 1432
Query: 162 NLRLKHTEEIT----RMRNDFERQVRE---IEAKY------------DKKMKMLRDELDL 202
+ L H ++ + + F++ + E I A+Y +K+ K L L
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 203 RRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKE 262
E E ER+N Q+ M+ + D+ +++ + A L++Q+E+MR +
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA----LEQQVEEMRTQL 1548
Query: 263 DHLEREMAEVSGQNKRLADPLQ----------KAREEMSEMQKQL---------ANYERD 303
+ LE E+ RL +Q + R+E +E +K+L A E +
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Query: 304 KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFK 363
++ A K E +LKDL+ + E + +V ++ +L + +E+++ +
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASR 1668
Query: 364 NLVL------ERKLQALSAAVEKKEVQFNEVLAAS 392
+ + E+KL++L A + +Q E LA+S
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEI----LQLQEELASS 1699
Score = 58.9 bits (141), Expect = 1e-08
Identities = 85/403 (21%), Positives = 172/403 (42%), Gaps = 54/403 (13%)
Query: 58 KIHTFWEITRRQLE-----EKKAELRNK----DREMEEAEERHQVEIKVYKQKVKHLLYE 108
K+ ++TR++ E E+ +++ K + E+EE E +HQ ++ K++L E
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE-----KNILAE 894
Query: 109 HQNNLTEMKAEGTVVM-KLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKH 167
TE+ AE + +LA K+ ++E + + R + E + Q L +E ++
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 168 TEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKN-----GQIHTL 222
EE ++++ + + K+K + +E+ L ++E+K + +
Sbjct: 955 LEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ 1014
Query: 223 MQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADP 282
+ EE ++ N +I+ L+E+++ K LE+ ++ G+ L D
Sbjct: 1015 LAEEEEKAKNLAKIRN----KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 283 LQKAREEMSEMQKQLANYER---------DKQILLCTKARLKVRE--KELKDLQWEHEVL 331
+ + + ++ E++ QLA E D + L A VRE ++ +LQ + E
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 332 EQRFTKVQQERDELYRKF-------------TAAIQEVQQKTGFKNLVLERKLQALSAAV 378
+ K ++++ +L + TAA QE++ K + V E K +AL
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR--EQEVAELK-KALEEET 1187
Query: 379 EKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQ 421
+ E Q ++ AL +S +LE K + K+ Q
Sbjct: 1188 KNHEAQIQDM---RQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Score = 53.9 bits (128), Expect = 3e-07
Identities = 63/335 (18%), Positives = 150/335 (44%), Gaps = 23/335 (6%)
Query: 24 EDMSKEQVEEHVSRIRE---ELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK 80
++ ++E+ + ++RE EL+ ER++R + K+ EI + LE + E NK
Sbjct: 1584 DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKM----EIDLKDLEAQ-IEAANK 1638
Query: 81 DR-EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLR 139
R E+ + + Q ++K Y+++++ + K + L + ++QE +
Sbjct: 1639 ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 140 KDMRALKVELKEQELASEVV--------VKNLRLKHTEEITRMRNDFERQVREIEAKYDK 191
+ E + ELA E+ + + + + I ++ + E + +E D+
Sbjct: 1699 SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758
Query: 192 --KMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALIN 249
K + D L+ E ++ N + L ++++E ++ + A I+
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDNAR-QQLERQNKELKAKLQELEGAVKSKFKATIS 1817
Query: 250 SLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLC 309
+L+ ++ + E+ LE+E E + NK + +K +E +++ + + ++ K+ +
Sbjct: 1818 ALEAKIGQL---EEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1874
Query: 310 TKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE 344
AR+K +++L++ + E K+Q+E D+
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 79.7 bits (195), Expect = 5e-15
Identities = 101/465 (21%), Positives = 207/465 (44%), Gaps = 63/465 (13%)
Query: 5 KKGKKGKAKGTPIVDGLAPEDMSKEQVEE---HVSRIREELDREREERNYFQLERDKIHT 61
KK ++ +A + D +A ++ + +++ E H+S ++E+LD ER RN + ++ +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 62 FWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAE-G 120
E + +LE + + +E + + E+ V K+ + H+ + EM+ +
Sbjct: 1147 ELEALKTELE----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202
Query: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
V +L ++ + + + D +E + +LA E+ V + +E+ + E
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---QAKQEVEHKKKKLEA 1259
Query: 181 QVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDI 240
QV+E+++K R + EL N ++H L Q E+ T + N
Sbjct: 1260 QVQELQSKCSD---------GERARAEL-------NDKVHKL-QNEVESVTGMLNEAEGK 1302
Query: 241 TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 300
+ + SL Q++D ++ R+ VS + ++L + ++++ E + N
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 301 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKF--TAAIQEVQQ 358
ER L +L +K+L+D E LE+ + Q+E + L +++ AA + +
Sbjct: 1363 ERHISTL---NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 359 KT------GFKNLVLERKLQ-ALSAAVEKKEVQFNEVLA-------------------AS 392
KT +LV++ Q L + +EKK+ +F+++LA A
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 393 NLDPAALTLVSRKLEDVLESKNS---TIKDLQYELAQVCKAHNDL 434
+ AL+L +R LE+ LE+K T K L+ E+ + + +D+
Sbjct: 1480 EKETKALSL-ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Score = 70.9 bits (172), Expect = 2e-12
Identities = 110/468 (23%), Positives = 196/468 (41%), Gaps = 79/468 (16%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKA------------ 75
K+++EE + + L+ E + Q ER K+ QLEE++A
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 76 -----ELRNKDREMEEAEERHQVEIKVYKQKVKHLL------YEHQNNLTEMK------- 117
+L ++ M++ + E K+ ++++ L E NLT++K
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 118 AEGTVVMKLAQKEHRIQESVLRK-------------DMRA----LKVEL--KEQELAS-- 156
+E V +K +K + E + RK D++A LK++L KE+EL +
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096
Query: 157 -----EVVVKNLRLKHTEEITRMRNDFERQV---REIEAKYDKKMKMLRDELDLRRKTEL 208
E+ KN LK E+ +D + + R K +K+ + L +EL+ KTEL
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTEL 1155
Query: 209 HEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 268
+ + Q L + E+ T +K ++ T S + Q+++MR+K E
Sbjct: 1156 EDTLDSTATQ-QELRAKREQEVTVLKKALDEET-------RSHEAQVQEMRQKHAQAVEE 1207
Query: 269 MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEH 328
+ E Q KR L K ++ + + LA ++ + +A+ +V K+ K L+ +
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAG-----ELRVLGQAKQEVEHKK-KKLEAQV 1261
Query: 329 EVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEV 388
+ L+ + + ++ R EL K EV+ TG N E K L+ V Q +
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN-EAEGKAIKLAKDVASLSSQLQDT 1320
Query: 389 LAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLR 436
+ VS KL + E +NS LQ +L + +A +L R
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNS----LQDQLDEEMEAKQNLER 1364
Score = 65.5 bits (158), Expect = 1e-10
Identities = 103/440 (23%), Positives = 188/440 (42%), Gaps = 65/440 (14%)
Query: 32 EEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK---DREMEEAE 88
EE + +EL + +E + + E ++ E QL E+K L+ + + E+
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVM----KLAQ-----KEHRIQESVLR 139
E +V + KQ+++ +L+E + L E + G + K+AQ +E +E R
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 140 KDMRALKV--ELKEQELASEVVV---KNLRLKHTEEITRMR-NDFERQVREIE------A 187
+ ++ KV E K ++L E++V +N +L ++ R +D + E E
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 188 KYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL 247
K K + + EL++R K EE+ ++ L ++ E +D D+ A
Sbjct: 1027 KLKNKHESMISELEVRLKK-----EEKSRQELEKLKRKLEGDASDFHEQIADLQ----AQ 1077
Query: 248 INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKARE---EMSEMQKQLANYERDK 304
I LK Q + KKE+ L+ +A + + + + L+K RE +S++Q+ L D
Sbjct: 1078 IAELKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL-----DS 1129
Query: 305 QILLCTKARLKVRE--KELKDLQWEHE--------------VLEQRFTKVQQERDELYRK 348
+ KA + R+ +EL+ L+ E E EQ T +++ DE R
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 349 FTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLED 408
A +QE++QK L +L+ A + + + L N D A V + +
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 409 VLESKNSTIKDLQYELAQVC 428
+E K ++ EL C
Sbjct: 1249 EVEHKKKKLEAQVQELQSKC 1268
Score = 61.6 bits (148), Expect = 1e-09
Identities = 100/426 (23%), Positives = 184/426 (43%), Gaps = 67/426 (15%)
Query: 30 QVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEE 89
Q+EE + ++++LD E E + + ++ ++++L++ + + +EE ++
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE----ALEEGKK 1395
Query: 90 RHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVM-KLAQKEHRIQESVLRKDMRALKVE 148
R Q EI+ NLT+ E KL + ++R+Q+ ++ L V+
Sbjct: 1396 RFQKEIE---------------NLTQQYEEKAAAYDKLEKTKNRLQQ-----ELDDLVVD 1435
Query: 149 LKEQ-ELASEVVVKNLR----LKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLR 203
L Q +L S + K + L + I+ D ER E EA+ +K+ K L L
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAR-EKETKALSLARALE 1493
Query: 204 RKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKED 263
E E ER N + M+ + D+ +++ + AL + QME+M+ + +
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLE 1549
Query: 264 HLEREMAEVSGQNKRLADPLQ----------KAREEMSE-----MQKQLANYERD----- 303
LE E+ RL +Q +AR+E +E +Q+QL YE +
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 304 KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK---- 359
KQ L A+ K+ E +LKDL E+ K ++E + RK A +++ Q++
Sbjct: 1610 KQRALAAAAKKKL-EGDLKDL----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 360 --TGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTI 417
+ + ++ + + ++E +Q E LAA+ L +L + L S S
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 418 KDLQYE 423
LQ E
Sbjct: 1725 NALQDE 1730
Score = 55.8 bits (133), Expect = 8e-08
Identities = 67/372 (18%), Positives = 162/372 (43%), Gaps = 37/372 (9%)
Query: 19 DGLAPEDMSKEQVEEHVSRIREELDRE--------REERNYFQLERDKIHTFWEITRRQL 70
D L + +K ++E ++ ++ + +R+ E+R Q + + T E R+Q
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 71 EEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHL------LYEHQNNLTEMKAEGTVVM 124
A + + ++++ E + IK ++ +K L + + Q L + +A +
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 125 KLAQKEHRIQESV------LRKDMRALK-----VELKEQELASEVV--------VKNLRL 165
A++ + +S+ L++D+ A + +L+++ELA E+ +++ +
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732
Query: 166 KHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQR 225
+ I ++ + E + +EA D+ K + L + +KN ++R
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 226 -HEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQ 284
++E + + + + I +L+ ++ + E+ +E+E E K L +
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL---EEQVEQEAREKQAATKSLKQKDK 1849
Query: 285 KAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE 344
K +E + +++ + E+ K+ AR+K +++L++ + E + + K+Q+E DE
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Query: 345 LYRKFTAAIQEV 356
A +EV
Sbjct: 1910 ATESNEAMGREV 1921
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/255 (23%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 180 RQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQI---HTLMQRHEEAFTDIKNY 236
RQ E++AK D+ K E + + EL E+E+ K+ Q+ L+Q +A T++
Sbjct: 849 RQEEEMQAKEDELQK--TKERQQKAENELKELEQ-KHSQLTEEKNLLQEQLQAETELYAE 905
Query: 237 YNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ 296
++ + A L+E + +M + + E ++ + K++A ++M ++++Q
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA-------QQMLDLEEQ 958
Query: 297 LANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQER---DELYRKFTAAI 353
L E +Q L K + + K+L+D E V++ + K+ +ER +E T +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLED---EILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 354 QEVQQKTGFKNLV-LERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLES 412
E ++K KNL L+ K +++ + +E + L L + RKLE
Sbjct: 1016 AEEEEKA--KNLTKLKNKHESMISELEVR-------LKKEEKSRQELEKLKRKLEGDASD 1066
Query: 413 KNSTIKDLQYELAQV 427
+ I DLQ ++A++
Sbjct: 1067 FHEQIADLQAQIAEL 1081
Score = 43.9 bits (102), Expect = 3e-04
Identities = 53/283 (18%), Positives = 119/283 (42%), Gaps = 39/283 (13%)
Query: 4 KKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFW 63
+KK K +A + + LA + +++Q + + EEL RN Q E+ ++
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 64 EITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV 123
+LEE++ + + +A ++ + ++ E
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAE----------------------QLSNELATE 1776
Query: 124 MKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVR 183
AQK ++ + R++ + L+ +L E E A + K+ +I ++ E++ R
Sbjct: 1777 RSTAQKNESARQQLERQN-KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 184 EIEA------KYDKKMK--MLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKN 235
E +A + DKK+K +L+ E + + + E E+ N ++ L ++ EEA + +
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 236 YYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKR 278
I N L+ ++++ + + + RE+ + + +R
Sbjct: 1896 ----INANR----RKLQRELDEATESNEAMGREVNALKSKLRR 1930
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 79.7 bits (195), Expect = 5e-15
Identities = 101/465 (21%), Positives = 207/465 (44%), Gaps = 63/465 (13%)
Query: 5 KKGKKGKAKGTPIVDGLAPEDMSKEQVEE---HVSRIREELDREREERNYFQLERDKIHT 61
KK ++ +A + D +A ++ + +++ E H+S ++E+LD ER RN + ++ +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 62 FWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAE-G 120
E + +LE + + +E + + E+ V K+ + H+ + EM+ +
Sbjct: 1154 ELEALKTELE----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209
Query: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
V +L ++ + + + D +E + +LA E+ V + +E+ + E
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---QAKQEVEHKKKKLEA 1266
Query: 181 QVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDI 240
QV+E+++K R + EL N ++H L Q E+ T + N
Sbjct: 1267 QVQELQSKCSD---------GERARAEL-------NDKVHKL-QNEVESVTGMLNEAEGK 1309
Query: 241 TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 300
+ + SL Q++D ++ R+ VS + ++L + ++++ E + N
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 301 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKF--TAAIQEVQQ 358
ER L +L +K+L+D E LE+ + Q+E + L +++ AA + +
Sbjct: 1370 ERHISTL---NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 359 KT------GFKNLVLERKLQ-ALSAAVEKKEVQFNEVLA-------------------AS 392
KT +LV++ Q L + +EKK+ +F+++LA A
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 393 NLDPAALTLVSRKLEDVLESKNS---TIKDLQYELAQVCKAHNDL 434
+ AL+L +R LE+ LE+K T K L+ E+ + + +D+
Sbjct: 1487 EKETKALSL-ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Score = 70.9 bits (172), Expect = 2e-12
Identities = 110/468 (23%), Positives = 196/468 (41%), Gaps = 79/468 (16%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKA------------ 75
K+++EE + + L+ E + Q ER K+ QLEE++A
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 76 -----ELRNKDREMEEAEERHQVEIKVYKQKVKHLL------YEHQNNLTEMK------- 117
+L ++ M++ + E K+ ++++ L E NLT++K
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 118 AEGTVVMKLAQKEHRIQESVLRK-------------DMRA----LKVEL--KEQELAS-- 156
+E V +K +K + E + RK D++A LK++L KE+EL +
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103
Query: 157 -----EVVVKNLRLKHTEEITRMRNDFERQV---REIEAKYDKKMKMLRDELDLRRKTEL 208
E+ KN LK E+ +D + + R K +K+ + L +EL+ KTEL
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTEL 1162
Query: 209 HEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 268
+ + Q L + E+ T +K ++ T S + Q+++MR+K E
Sbjct: 1163 EDTLDSTATQ-QELRAKREQEVTVLKKALDEET-------RSHEAQVQEMRQKHAQAVEE 1214
Query: 269 MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEH 328
+ E Q KR L K ++ + + LA ++ + +A+ +V K+ K L+ +
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAG-----ELRVLGQAKQEVEHKK-KKLEAQV 1268
Query: 329 EVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEV 388
+ L+ + + ++ R EL K EV+ TG N E K L+ V Q +
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN-EAEGKAIKLAKDVASLSSQLQDT 1327
Query: 389 LAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLR 436
+ VS KL + E +NS LQ +L + +A +L R
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNS----LQDQLDEEMEAKQNLER 1371
Score = 65.5 bits (158), Expect = 1e-10
Identities = 103/440 (23%), Positives = 188/440 (42%), Gaps = 65/440 (14%)
Query: 32 EEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK---DREMEEAE 88
EE + +EL + +E + + E ++ E QL E+K L+ + + E+
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVM----KLAQ-----KEHRIQESVLR 139
E +V + KQ+++ +L+E + L E + G + K+AQ +E +E R
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 140 KDMRALKV--ELKEQELASEVVV---KNLRLKHTEEITRMR-NDFERQVREIE------A 187
+ ++ KV E K ++L E++V +N +L ++ R +D + E E
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 188 KYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL 247
K K + + EL++R K EE+ ++ L ++ E +D D+ A
Sbjct: 1034 KLKNKHESMISELEVRLKK-----EEKSRQELEKLKRKLEGDASDFHEQIADLQ----AQ 1084
Query: 248 INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKARE---EMSEMQKQLANYERDK 304
I LK Q + KKE+ L+ +A + + + + L+K RE +S++Q+ L D
Sbjct: 1085 IAELKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL-----DS 1136
Query: 305 QILLCTKARLKVRE--KELKDLQWEHE--------------VLEQRFTKVQQERDELYRK 348
+ KA + R+ +EL+ L+ E E EQ T +++ DE R
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 349 FTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLED 408
A +QE++QK L +L+ A + + + L N D A V + +
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 409 VLESKNSTIKDLQYELAQVC 428
+E K ++ EL C
Sbjct: 1256 EVEHKKKKLEAQVQELQSKC 1275
Score = 61.6 bits (148), Expect = 1e-09
Identities = 100/426 (23%), Positives = 184/426 (43%), Gaps = 67/426 (15%)
Query: 30 QVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEE 89
Q+EE + ++++LD E E + + ++ ++++L++ + + +EE ++
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE----ALEEGKK 1402
Query: 90 RHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVM-KLAQKEHRIQESVLRKDMRALKVE 148
R Q EI+ NLT+ E KL + ++R+Q+ ++ L V+
Sbjct: 1403 RFQKEIE---------------NLTQQYEEKAAAYDKLEKTKNRLQQ-----ELDDLVVD 1442
Query: 149 LKEQ-ELASEVVVKNLR----LKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLR 203
L Q +L S + K + L + I+ D ER E EA+ +K+ K L L
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAR-EKETKALSLARALE 1500
Query: 204 RKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKED 263
E E ER N + M+ + D+ +++ + AL + QME+M+ + +
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLE 1556
Query: 264 HLEREMAEVSGQNKRLADPLQ----------KAREEMSE-----MQKQLANYERD----- 303
LE E+ RL +Q +AR+E +E +Q+QL YE +
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 304 KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK---- 359
KQ L A+ K+ E +LKDL E+ K ++E + RK A +++ Q++
Sbjct: 1617 KQRALAAAAKKKL-EGDLKDL----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 360 --TGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTI 417
+ + ++ + + ++E +Q E LAA+ L +L + L S S
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 418 KDLQYE 423
LQ E
Sbjct: 1732 NALQDE 1737
Score = 55.8 bits (133), Expect = 8e-08
Identities = 67/372 (18%), Positives = 162/372 (43%), Gaps = 37/372 (9%)
Query: 19 DGLAPEDMSKEQVEEHVSRIREELDRE--------REERNYFQLERDKIHTFWEITRRQL 70
D L + +K ++E ++ ++ + +R+ E+R Q + + T E R+Q
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 71 EEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHL------LYEHQNNLTEMKAEGTVVM 124
A + + ++++ E + IK ++ +K L + + Q L + +A +
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 125 KLAQKEHRIQESV------LRKDMRALK-----VELKEQELASEVV--------VKNLRL 165
A++ + +S+ L++D+ A + +L+++ELA E+ +++ +
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739
Query: 166 KHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQR 225
+ I ++ + E + +EA D+ K + L + +KN ++R
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 226 -HEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQ 284
++E + + + + I +L+ ++ + E+ +E+E E K L +
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL---EEQVEQEAREKQAATKSLKQKDK 1856
Query: 285 KAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE 344
K +E + +++ + E+ K+ AR+K +++L++ + E + + K+Q+E DE
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Query: 345 LYRKFTAAIQEV 356
A +EV
Sbjct: 1917 ATESNEAMGREV 1928
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/255 (23%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 180 RQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQI---HTLMQRHEEAFTDIKNY 236
RQ E++AK D+ K E + + EL E+E+ K+ Q+ L+Q +A T++
Sbjct: 856 RQEEEMQAKEDELQK--TKERQQKAENELKELEQ-KHSQLTEEKNLLQEQLQAETELYAE 912
Query: 237 YNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ 296
++ + A L+E + +M + + E ++ + K++A ++M ++++Q
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA-------QQMLDLEEQ 965
Query: 297 LANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQER---DELYRKFTAAI 353
L E +Q L K + + K+L+D E V++ + K+ +ER +E T +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLED---EILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 354 QEVQQKTGFKNLV-LERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLES 412
E ++K KNL L+ K +++ + +E + L L + RKLE
Sbjct: 1023 AEEEEKA--KNLTKLKNKHESMISELEVR-------LKKEEKSRQELEKLKRKLEGDASD 1073
Query: 413 KNSTIKDLQYELAQV 427
+ I DLQ ++A++
Sbjct: 1074 FHEQIADLQAQIAEL 1088
Score = 43.9 bits (102), Expect = 3e-04
Identities = 53/283 (18%), Positives = 119/283 (42%), Gaps = 39/283 (13%)
Query: 4 KKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFW 63
+KK K +A + + LA + +++Q + + EEL RN Q E+ ++
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 64 EITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV 123
+LEE++ + + +A ++ + ++ E
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAE----------------------QLSNELATE 1783
Query: 124 MKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVR 183
AQK ++ + R++ + L+ +L E E A + K+ +I ++ E++ R
Sbjct: 1784 RSTAQKNESARQQLERQN-KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 184 EIEA------KYDKKMK--MLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKN 235
E +A + DKK+K +L+ E + + + E E+ N ++ L ++ EEA + +
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 236 YYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKR 278
I N L+ ++++ + + + RE+ + + +R
Sbjct: 1903 ----INANR----RKLQRELDEATESNEAMGREVNALKSKLRR 1937
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 79.7 bits (195), Expect = 5e-15
Identities = 101/465 (21%), Positives = 207/465 (44%), Gaps = 63/465 (13%)
Query: 5 KKGKKGKAKGTPIVDGLAPEDMSKEQVEE---HVSRIREELDREREERNYFQLERDKIHT 61
KK ++ +A + D +A ++ + +++ E H+S ++E+LD ER RN + ++ +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 62 FWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAE-G 120
E + +LE + + +E + + E+ V K+ + H+ + EM+ +
Sbjct: 1154 ELEALKTELE----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209
Query: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
V +L ++ + + + D +E + +LA E+ V + +E+ + E
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---QAKQEVEHKKKKLEA 1266
Query: 181 QVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDI 240
QV+E+++K R + EL N ++H L Q E+ T + N
Sbjct: 1267 QVQELQSKCSD---------GERARAEL-------NDKVHKL-QNEVESVTGMLNEAEGK 1309
Query: 241 TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 300
+ + SL Q++D ++ R+ VS + ++L + ++++ E + N
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 301 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKF--TAAIQEVQQ 358
ER L +L +K+L+D E LE+ + Q+E + L +++ AA + +
Sbjct: 1370 ERHISTL---NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 359 KT------GFKNLVLERKLQ-ALSAAVEKKEVQFNEVLA-------------------AS 392
KT +LV++ Q L + +EKK+ +F+++LA A
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 393 NLDPAALTLVSRKLEDVLESKNS---TIKDLQYELAQVCKAHNDL 434
+ AL+L +R LE+ LE+K T K L+ E+ + + +D+
Sbjct: 1487 EKETKALSL-ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Score = 70.9 bits (172), Expect = 2e-12
Identities = 110/468 (23%), Positives = 196/468 (41%), Gaps = 79/468 (16%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKA------------ 75
K+++EE + + L+ E + Q ER K+ QLEE++A
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 76 -----ELRNKDREMEEAEERHQVEIKVYKQKVKHLL------YEHQNNLTEMK------- 117
+L ++ M++ + E K+ ++++ L E NLT++K
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 118 AEGTVVMKLAQKEHRIQESVLRK-------------DMRA----LKVEL--KEQELAS-- 156
+E V +K +K + E + RK D++A LK++L KE+EL +
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103
Query: 157 -----EVVVKNLRLKHTEEITRMRNDFERQV---REIEAKYDKKMKMLRDELDLRRKTEL 208
E+ KN LK E+ +D + + R K +K+ + L +EL+ KTEL
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTEL 1162
Query: 209 HEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 268
+ + Q L + E+ T +K ++ T S + Q+++MR+K E
Sbjct: 1163 EDTLDSTATQ-QELRAKREQEVTVLKKALDEET-------RSHEAQVQEMRQKHAQAVEE 1214
Query: 269 MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEH 328
+ E Q KR L K ++ + + LA ++ + +A+ +V K+ K L+ +
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAG-----ELRVLGQAKQEVEHKK-KKLEAQV 1268
Query: 329 EVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEV 388
+ L+ + + ++ R EL K EV+ TG N E K L+ V Q +
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN-EAEGKAIKLAKDVASLSSQLQDT 1327
Query: 389 LAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLR 436
+ VS KL + E +NS LQ +L + +A +L R
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNS----LQDQLDEEMEAKQNLER 1371
Score = 65.5 bits (158), Expect = 1e-10
Identities = 103/440 (23%), Positives = 188/440 (42%), Gaps = 65/440 (14%)
Query: 32 EEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK---DREMEEAE 88
EE + +EL + +E + + E ++ E QL E+K L+ + + E+
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVM----KLAQ-----KEHRIQESVLR 139
E +V + KQ+++ +L+E + L E + G + K+AQ +E +E R
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 140 KDMRALKV--ELKEQELASEVVV---KNLRLKHTEEITRMR-NDFERQVREIE------A 187
+ ++ KV E K ++L E++V +N +L ++ R +D + E E
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 188 KYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL 247
K K + + EL++R K EE+ ++ L ++ E +D D+ A
Sbjct: 1034 KLKNKHESMISELEVRLKK-----EEKSRQELEKLKRKLEGDASDFHEQIADLQ----AQ 1084
Query: 248 INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKARE---EMSEMQKQLANYERDK 304
I LK Q + KKE+ L+ +A + + + + L+K RE +S++Q+ L D
Sbjct: 1085 IAELKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL-----DS 1136
Query: 305 QILLCTKARLKVRE--KELKDLQWEHE--------------VLEQRFTKVQQERDELYRK 348
+ KA + R+ +EL+ L+ E E EQ T +++ DE R
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 349 FTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLED 408
A +QE++QK L +L+ A + + + L N D A V + +
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 409 VLESKNSTIKDLQYELAQVC 428
+E K ++ EL C
Sbjct: 1256 EVEHKKKKLEAQVQELQSKC 1275
Score = 61.6 bits (148), Expect = 1e-09
Identities = 100/426 (23%), Positives = 184/426 (43%), Gaps = 67/426 (15%)
Query: 30 QVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEE 89
Q+EE + ++++LD E E + + ++ ++++L++ + + +EE ++
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE----ALEEGKK 1402
Query: 90 RHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVM-KLAQKEHRIQESVLRKDMRALKVE 148
R Q EI+ NLT+ E KL + ++R+Q+ ++ L V+
Sbjct: 1403 RFQKEIE---------------NLTQQYEEKAAAYDKLEKTKNRLQQ-----ELDDLVVD 1442
Query: 149 LKEQ-ELASEVVVKNLR----LKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLR 203
L Q +L S + K + L + I+ D ER E EA+ +K+ K L L
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAR-EKETKALSLARALE 1500
Query: 204 RKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKED 263
E E ER N + M+ + D+ +++ + AL + QME+M+ + +
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLE 1556
Query: 264 HLEREMAEVSGQNKRLADPLQ----------KAREEMSE-----MQKQLANYERD----- 303
LE E+ RL +Q +AR+E +E +Q+QL YE +
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 304 KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK---- 359
KQ L A+ K+ E +LKDL E+ K ++E + RK A +++ Q++
Sbjct: 1617 KQRALAAAAKKKL-EGDLKDL----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 360 --TGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTI 417
+ + ++ + + ++E +Q E LAA+ L +L + L S S
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 418 KDLQYE 423
LQ E
Sbjct: 1732 NALQDE 1737
Score = 55.8 bits (133), Expect = 8e-08
Identities = 67/372 (18%), Positives = 162/372 (43%), Gaps = 37/372 (9%)
Query: 19 DGLAPEDMSKEQVEEHVSRIREELDRE--------REERNYFQLERDKIHTFWEITRRQL 70
D L + +K ++E ++ ++ + +R+ E+R Q + + T E R+Q
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 71 EEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHL------LYEHQNNLTEMKAEGTVVM 124
A + + ++++ E + IK ++ +K L + + Q L + +A +
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 125 KLAQKEHRIQESV------LRKDMRALK-----VELKEQELASEVV--------VKNLRL 165
A++ + +S+ L++D+ A + +L+++ELA E+ +++ +
Sbjct: 1680 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739
Query: 166 KHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQR 225
+ I ++ + E + +EA D+ K + L + +KN ++R
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 226 -HEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQ 284
++E + + + + I +L+ ++ + E+ +E+E E K L +
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL---EEQVEQEAREKQAATKSLKQKDK 1856
Query: 285 KAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE 344
K +E + +++ + E+ K+ AR+K +++L++ + E + + K+Q+E DE
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Query: 345 LYRKFTAAIQEV 356
A +EV
Sbjct: 1917 ATESNEAMGREV 1928
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/255 (23%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 180 RQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQI---HTLMQRHEEAFTDIKNY 236
RQ E++AK D+ K E + + EL E+E+ K+ Q+ L+Q +A T++
Sbjct: 856 RQEEEMQAKEDELQK--TKERQQKAENELKELEQ-KHSQLTEEKNLLQEQLQAETELYAE 912
Query: 237 YNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ 296
++ + A L+E + +M + + E ++ + K++A ++M ++++Q
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA-------QQMLDLEEQ 965
Query: 297 LANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQER---DELYRKFTAAI 353
L E +Q L K + + K+L+D E V++ + K+ +ER +E T +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLED---EILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 354 QEVQQKTGFKNLV-LERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLES 412
E ++K KNL L+ K +++ + +E + L L + RKLE
Sbjct: 1023 AEEEEKA--KNLTKLKNKHESMISELEVR-------LKKEEKSRQELEKLKRKLEGDASD 1073
Query: 413 KNSTIKDLQYELAQV 427
+ I DLQ ++A++
Sbjct: 1074 FHEQIADLQAQIAEL 1088
Score = 43.1 bits (100), Expect = 6e-04
Identities = 47/234 (20%), Positives = 99/234 (42%), Gaps = 31/234 (13%)
Query: 4 KKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFW 63
+KK K +A + + LA + +++Q + + EEL RN Q E+ ++
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 64 EITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV 123
+LEE++ + + +A ++ + ++ E
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAE----------------------QLSNELATE 1783
Query: 124 MKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVR 183
AQK ++ + R++ + L+ +L E E A + K+ +I ++ E++ R
Sbjct: 1784 RSTAQKNESARQQLERQN-KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 184 EIEA------KYDKKMK--MLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEA 229
E +A + DKK+K +L+ E + + + E E+ N ++ L ++ EEA
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 79.7 bits (195), Expect = 5e-15
Identities = 101/465 (21%), Positives = 207/465 (44%), Gaps = 63/465 (13%)
Query: 5 KKGKKGKAKGTPIVDGLAPEDMSKEQVEE---HVSRIREELDREREERNYFQLERDKIHT 61
KK ++ +A + D +A ++ + +++ E H+S ++E+LD ER RN + ++ +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 62 FWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAE-G 120
E + +LE + + +E + + E+ V K+ + H+ + EM+ +
Sbjct: 1147 ELEALKTELE----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202
Query: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
V +L ++ + + + D +E + +LA E+ V + +E+ + E
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---QAKQEVEHKKKKLEA 1259
Query: 181 QVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDI 240
QV+E+++K R + EL N ++H L Q E+ T + N
Sbjct: 1260 QVQELQSKCSD---------GERARAEL-------NDKVHKL-QNEVESVTGMLNEAEGK 1302
Query: 241 TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 300
+ + SL Q++D ++ R+ VS + ++L + ++++ E + N
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 301 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKF--TAAIQEVQQ 358
ER L +L +K+L+D E LE+ + Q+E + L +++ AA + +
Sbjct: 1363 ERHISTL---NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 359 KT------GFKNLVLERKLQ-ALSAAVEKKEVQFNEVLA-------------------AS 392
KT +LV++ Q L + +EKK+ +F+++LA A
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 393 NLDPAALTLVSRKLEDVLESKNS---TIKDLQYELAQVCKAHNDL 434
+ AL+L +R LE+ LE+K T K L+ E+ + + +D+
Sbjct: 1480 EKETKALSL-ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Score = 70.9 bits (172), Expect = 2e-12
Identities = 110/468 (23%), Positives = 196/468 (41%), Gaps = 79/468 (16%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKA------------ 75
K+++EE + + L+ E + Q ER K+ QLEE++A
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 76 -----ELRNKDREMEEAEERHQVEIKVYKQKVKHLL------YEHQNNLTEMK------- 117
+L ++ M++ + E K+ ++++ L E NLT++K
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 118 AEGTVVMKLAQKEHRIQESVLRK-------------DMRA----LKVEL--KEQELAS-- 156
+E V +K +K + E + RK D++A LK++L KE+EL +
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096
Query: 157 -----EVVVKNLRLKHTEEITRMRNDFERQV---REIEAKYDKKMKMLRDELDLRRKTEL 208
E+ KN LK E+ +D + + R K +K+ + L +EL+ KTEL
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTEL 1155
Query: 209 HEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 268
+ + Q L + E+ T +K ++ T S + Q+++MR+K E
Sbjct: 1156 EDTLDSTATQ-QELRAKREQEVTVLKKALDEET-------RSHEAQVQEMRQKHAQAVEE 1207
Query: 269 MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEH 328
+ E Q KR L K ++ + + LA ++ + +A+ +V K+ K L+ +
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAG-----ELRVLGQAKQEVEHKK-KKLEAQV 1261
Query: 329 EVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEV 388
+ L+ + + ++ R EL K EV+ TG N E K L+ V Q +
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN-EAEGKAIKLAKDVASLSSQLQDT 1320
Query: 389 LAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLR 436
+ VS KL + E +NS LQ +L + +A +L R
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNS----LQDQLDEEMEAKQNLER 1364
Score = 65.5 bits (158), Expect = 1e-10
Identities = 103/440 (23%), Positives = 188/440 (42%), Gaps = 65/440 (14%)
Query: 32 EEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK---DREMEEAE 88
EE + +EL + +E + + E ++ E QL E+K L+ + + E+
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKEL----EQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVM----KLAQ-----KEHRIQESVLR 139
E +V + KQ+++ +L+E + L E + G + K+AQ +E +E R
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 140 KDMRALKV--ELKEQELASEVVV---KNLRLKHTEEITRMR-NDFERQVREIE------A 187
+ ++ KV E K ++L E++V +N +L ++ R +D + E E
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 188 KYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL 247
K K + + EL++R K EE+ ++ L ++ E +D D+ A
Sbjct: 1027 KLKNKHESMISELEVRLKK-----EEKSRQELEKLKRKLEGDASDFHEQIADLQ----AQ 1077
Query: 248 INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKARE---EMSEMQKQLANYERDK 304
I LK Q + KKE+ L+ +A + + + + L+K RE +S++Q+ L D
Sbjct: 1078 IAELKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL-----DS 1129
Query: 305 QILLCTKARLKVRE--KELKDLQWEHE--------------VLEQRFTKVQQERDELYRK 348
+ KA + R+ +EL+ L+ E E EQ T +++ DE R
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 349 FTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLED 408
A +QE++QK L +L+ A + + + L N D A V + +
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 409 VLESKNSTIKDLQYELAQVC 428
+E K ++ EL C
Sbjct: 1249 EVEHKKKKLEAQVQELQSKC 1268
Score = 61.6 bits (148), Expect = 1e-09
Identities = 100/426 (23%), Positives = 184/426 (43%), Gaps = 67/426 (15%)
Query: 30 QVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEE 89
Q+EE + ++++LD E E + + ++ ++++L++ + + +EE ++
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE----ALEEGKK 1395
Query: 90 RHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVM-KLAQKEHRIQESVLRKDMRALKVE 148
R Q EI+ NLT+ E KL + ++R+Q+ ++ L V+
Sbjct: 1396 RFQKEIE---------------NLTQQYEEKAAAYDKLEKTKNRLQQ-----ELDDLVVD 1435
Query: 149 LKEQ-ELASEVVVKNLR----LKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLR 203
L Q +L S + K + L + I+ D ER E EA+ +K+ K L L
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD-ERDRAEAEAR-EKETKALSLARALE 1493
Query: 204 RKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKED 263
E E ER N + M+ + D+ +++ + AL + QME+M+ + +
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLE 1549
Query: 264 HLEREMAEVSGQNKRLADPLQ----------KAREEMSE-----MQKQLANYERD----- 303
LE E+ RL +Q +AR+E +E +Q+QL YE +
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 304 KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK---- 359
KQ L A+ K+ E +LKDL E+ K ++E + RK A +++ Q++
Sbjct: 1610 KQRALAAAAKKKL-EGDLKDL----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 360 --TGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTI 417
+ + ++ + + ++E +Q E LAA+ L +L + L S S
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 418 KDLQYE 423
LQ E
Sbjct: 1725 NALQDE 1730
Score = 55.8 bits (133), Expect = 8e-08
Identities = 67/372 (18%), Positives = 162/372 (43%), Gaps = 37/372 (9%)
Query: 19 DGLAPEDMSKEQVEEHVSRIREELDRE--------REERNYFQLERDKIHTFWEITRRQL 70
D L + +K ++E ++ ++ + +R+ E+R Q + + T E R+Q
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 71 EEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHL------LYEHQNNLTEMKAEGTVVM 124
A + + ++++ E + IK ++ +K L + + Q L + +A +
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 125 KLAQKEHRIQESV------LRKDMRALK-----VELKEQELASEVV--------VKNLRL 165
A++ + +S+ L++D+ A + +L+++ELA E+ +++ +
Sbjct: 1673 ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732
Query: 166 KHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQR 225
+ I ++ + E + +EA D+ K + L + +KN ++R
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 226 -HEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQ 284
++E + + + + I +L+ ++ + E+ +E+E E K L +
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL---EEQVEQEAREKQAATKSLKQKDK 1849
Query: 285 KAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE 344
K +E + +++ + E+ K+ AR+K +++L++ + E + + K+Q+E DE
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Query: 345 LYRKFTAAIQEV 356
A +EV
Sbjct: 1910 ATESNEAMGREV 1921
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/255 (23%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 180 RQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQI---HTLMQRHEEAFTDIKNY 236
RQ E++AK D+ K E + + EL E+E+ K+ Q+ L+Q +A T++
Sbjct: 849 RQEEEMQAKEDELQK--TKERQQKAENELKELEQ-KHSQLTEEKNLLQEQLQAETELYAE 905
Query: 237 YNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ 296
++ + A L+E + +M + + E ++ + K++A ++M ++++Q
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA-------QQMLDLEEQ 958
Query: 297 LANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQER---DELYRKFTAAI 353
L E +Q L K + + K+L+D E V++ + K+ +ER +E T +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLED---EILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 354 QEVQQKTGFKNLV-LERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLES 412
E ++K KNL L+ K +++ + +E + L L + RKLE
Sbjct: 1016 AEEEEKA--KNLTKLKNKHESMISELEVR-------LKKEEKSRQELEKLKRKLEGDASD 1066
Query: 413 KNSTIKDLQYELAQV 427
+ I DLQ ++A++
Sbjct: 1067 FHEQIADLQAQIAEL 1081
Score = 43.1 bits (100), Expect = 6e-04
Identities = 47/234 (20%), Positives = 99/234 (42%), Gaps = 31/234 (13%)
Query: 4 KKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFW 63
+KK K +A + + LA + +++Q + + EEL RN Q E+ ++
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 64 EITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV 123
+LEE++ + + +A ++ + ++ E
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAE----------------------QLSNELATE 1776
Query: 124 MKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVR 183
AQK ++ + R++ + L+ +L E E A + K+ +I ++ E++ R
Sbjct: 1777 RSTAQKNESARQQLERQN-KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 184 EIEA------KYDKKMK--MLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEA 229
E +A + DKK+K +L+ E + + + E E+ N ++ L ++ EEA
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 79.0 bits (193), Expect = 9e-15
Identities = 77/350 (22%), Positives = 167/350 (47%), Gaps = 43/350 (12%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLE---------RDKIHTFWEITR--RQLEE 72
E K + +E R +EE+ E+EE+ Q E R + WE R+LEE
Sbjct: 386 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 445
Query: 73 K---------KAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV 123
K + E R ++ ++ E E+R + E K+++Q+ K + E + + E +
Sbjct: 446 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK--IREQEEKIREQEE----- 498
Query: 124 MKLAQKEHRI--QESVLRKDMRALKVEL--KEQELASEVVVKNLRLKHTEEITRMRNDFE 179
K+ ++E +I QE + ++ R + E+ +E+++ + + + K E+ ++R E
Sbjct: 499 -KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEE 557
Query: 180 RQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYND 239
+ R+ E +D++ K+ E + R+ E +E K + ++ EE + + +
Sbjct: 558 KMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617
Query: 240 ITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLAN 299
+ EQ E M+++E+ + R+ ++ Q K++ + +K RE+ MQ+Q
Sbjct: 618 QE-------EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 670
Query: 300 YERDKQILLCTKARLKVREKELK---DLQWEHEV-LEQRFTKVQQERDEL 345
++ + + +++ +E++++ + WE EV L Q+ K+Q+ ++ L
Sbjct: 671 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 77.8 bits (190), Expect = 2e-14
Identities = 73/321 (22%), Positives = 155/321 (48%), Gaps = 29/321 (9%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLE---EKKAELRNKDREM 84
+E+++E +IRE+ ++ RE+ + + + + E RRQ E EK+ ++R ++ M
Sbjct: 374 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 433
Query: 85 EEAEER-HQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMR 143
E EE+ ++E K+++Q+ + E + + K+ ++E R QE + +
Sbjct: 434 WEKEEKIRELEEKMHEQE----------KIREQEEKRQEEEKIREQEKR-QEQEAKMWRQ 482
Query: 144 ALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLR 203
K+ +E+++ + + + E ++R + +RQ E E + ++ K+ E R
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ--EQEEMWRQEEKIREQEEIWR 540
Query: 204 RKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKED 263
+K ++HE EE+ Q M R EE D + + ++EQ E +R++E+
Sbjct: 541 QKEKIHEQEEKIRKQ-EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEE 599
Query: 264 HLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKD 323
+ + Q +++ + +K E+ +MQ+Q R ++ K+RE+E K
Sbjct: 600 KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEE---------KIREQEKKI 650
Query: 324 LQWEHEVLEQRFTKVQQERDE 344
+ E ++ EQ ++ QE++E
Sbjct: 651 REQEEKIREQE--EMMQEQEE 669
Score = 67.0 bits (162), Expect = 4e-11
Identities = 81/384 (21%), Positives = 181/384 (47%), Gaps = 43/384 (11%)
Query: 32 EEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERH 91
++ R EEL +ER+ + +L R+ I T +L+EK A+L+ K + +E +
Sbjct: 249 KKKADRYIEELTKERDALS-LELYRNTI------TDEELKEKNAKLQEKLQLVESEKSEI 301
Query: 92 QVEIKVYKQKVKH--LLYEHQNNLTEMKAEGTVVMKLAQK--------------EHRIQE 135
Q+ +K K+K++ LL Q E G + ++ K + +E
Sbjct: 302 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 361
Query: 136 SVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDF-----ERQVREIEAKYD 190
+ R++ + + E K QE ++ + +++ EE R + + E+ R+ E ++
Sbjct: 362 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421
Query: 191 KKMKMLR-DELDLRRKTELHEVEERKNGQIHTLMQ---RHEEAFTDIKNYYNDITLNNLA 246
K+ KM R +E+ ++ ++ E+EE+ + Q Q R EE + +
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 481
Query: 247 LINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYE---RD 303
++EQ E +R++E+ + R+ ++ Q K + ++ +EEM ++++ E R
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 541
Query: 304 KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFK 363
K+ + + K+R++E K + E ++ +Q K++++ ++++R+ I+E ++K +
Sbjct: 542 KEKI--HEQEEKIRKQEEKMWRQEEKMHDQE-EKIREQEEKVWRQ-EEKIREQEEKIREQ 597
Query: 364 NLVLERKLQALSAAVEKKEVQFNE 387
E K++ +++E + E
Sbjct: 598 ----EEKIREQEEMTQEQEEKMGE 617
Score = 32.3 bits (72), Expect = 0.97
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 6/78 (7%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLER-----DKIHTFWEITRRQLEEKKAELR 78
E K + +E R +EE+ +E+EE+ + Q E+ +K+ E RRQ EEK E
Sbjct: 645 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ-EEKMWEQE 703
Query: 79 NKDREMEEAEERHQVEIK 96
+ R+ EE + HQ ++
Sbjct: 704 VRLRQQEEKMQEHQEHLE 721
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 79.0 bits (193), Expect = 9e-15
Identities = 100/453 (22%), Positives = 205/453 (45%), Gaps = 45/453 (9%)
Query: 6 KGKKGKAKGTPIVDGLAPEDMSKE----QVEEHVSRIREELDREREERNYFQLERDKIHT 61
+ K K + + G+ + + +E Q++E + + E+L R EE F+ ER+++
Sbjct: 630 RSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEE---FEGERERLQR 686
Query: 62 FWEIT---RRQLEEKKAELRNKDREMEEAEERHQVEIKVYK------QKVKHLLYEHQNN 112
+ +QLE+ K L +D+++E ++ H +K Q + L Q +
Sbjct: 687 MADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTH 746
Query: 113 LTEMKAE-GTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEI 171
E++A G + + A +E I +L+ + L+ L+ + E + + R EE
Sbjct: 747 YDELQARLGELQGEAASREDTI--CLLQNEKIILEAALQAAKSGKEELDRGAR--RLEEG 802
Query: 172 TRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFT 231
T ++ ++RE A +++ L+ E +K ++ +++E+ Q +++ + T
Sbjct: 803 TEETSETLEKLREELAIKSGQVEHLQQETAALKK-QMQKIKEQFLQQ-KVMVEAYRRDAT 860
Query: 232 DIKNYYNDITLNNLALINSLKEQMEDMRKKE----------DHLEREMAEVSGQNKRLAD 281
+++ L + LKE +++ + L RE+A+V L
Sbjct: 861 SKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEG 920
Query: 282 PLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQE 341
LQ A++E EM+ L + + DK+ ++ + +K++++LQ E + T+ +Q+
Sbjct: 921 HLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE---ARKAITEQKQK 977
Query: 342 RDELYRKFTAAIQEVQQK-TGFKNLV--LERKLQALSAAVEKKEVQFNEVLAASNLDPAA 398
L T+A +E++ K ++N V L R+LQ AA E + + ++ A ++
Sbjct: 978 MRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSS 1037
Query: 399 LTLVSR------KLEDVLESKNSTIKDLQYELA 425
L L R +L+ V SK K+LQ +A
Sbjct: 1038 LALHERIQALEAELQAVSHSKTLLEKELQEVIA 1070
Score = 54.7 bits (130), Expect = 2e-07
Identities = 82/418 (19%), Positives = 167/418 (39%), Gaps = 64/418 (15%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
++++E H+ ++ + ++ + + +I + R+ + E+K ++R ++ A
Sbjct: 929 RDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSA 988
Query: 88 EERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKL-AQKEHRIQESVLRKDMRALK 146
++ + + K Y+ V L Q L +A + +L AQ L + ++AL+
Sbjct: 989 QKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALE 1048
Query: 147 VELK---------EQELASEVVVKNLRLKHTEE------------------ITRMRNDFE 179
EL+ E+EL + + + L+ + E I R+ +
Sbjct: 1049 AELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNK 1108
Query: 180 RQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERK--------NGQIHTLMQRHEEAFT 231
+ E+E + K + + LR + E K N Q+ ++QR EE
Sbjct: 1109 KLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDR 1168
Query: 232 DIKNYYNDITLN---NLALINSLKEQMEDMRKKEDHLEREMA----EVSGQNKRL----- 279
+K+ + + +NSLKEQ+ + + H R E+S K L
Sbjct: 1169 QMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEH 1228
Query: 280 --------ADPLQ----KAREEMSEMQKQLANYERDKQILLCTK----ARLKVREKELKD 323
AD LQ K +E+++ Q +LA Q+L ++ V +E+++
Sbjct: 1229 LVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMEN 1288
Query: 324 LQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKK 381
L+WE + E+ ++Q+ D ++ ++ +QQ LE + LS + K
Sbjct: 1289 LKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDK 1346
Score = 50.8 bits (120), Expect = 3e-06
Identities = 84/438 (19%), Positives = 182/438 (41%), Gaps = 48/438 (10%)
Query: 29 EQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAE 88
E+ E + ++REEL + + + Q E + + + Q ++K + R+ +
Sbjct: 804 EETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKD 863
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVE 148
+ E+K ++++ L E + L ++ E + HR + + +R+ M L+
Sbjct: 864 QLIS-ELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHR-EVAQVRQHMADLEGH 921
Query: 149 LKEQELASEVVVKNLR-LKHTEE----ITRMRNDFERQVREIEAKYDK-------KMKML 196
L+ + + + +L+ L+ +E +T ++Q+ E++ + K KM+ L
Sbjct: 922 LQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRL 981
Query: 197 RDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQME 256
+L +K E+ + + L +R +EA D L L +
Sbjct: 982 GSDLTSAQK-EMKTKHKAYENAVGILSRRLQEALA--AKEAADAELGQLRAQGGSSDSSL 1038
Query: 257 DMRKKEDHLEREMAEVSGQNKRLADPLQKA----REEMSEMQKQLANYERDKQILLCTKA 312
+ ++ LE E+ VS L LQ+ +E+ E ++++ E + Q +
Sbjct: 1039 ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRK 1098
Query: 313 RLKVREKELKDLQWEHEVLEQRFTKVQQERDELYR-----------------KFTAAIQE 355
++K E+ K L E E + + T + Q L + +Q
Sbjct: 1099 KIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQA 1158
Query: 356 VQQKTGFKNLVLERKLQALSAAVEKKEVQFN---EVLAASNLDPA-------ALTLVSRK 405
V Q+ ++ ++ +QAL A++EK++ + N E +AA+ ++ A +L +
Sbjct: 1159 VLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSE 1218
Query: 406 LEDVLESKNSTIKDLQYE 423
++ L++K ++ LQ E
Sbjct: 1219 VKKELQAKEHLVQKLQAE 1236
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/301 (19%), Positives = 136/301 (45%), Gaps = 32/301 (10%)
Query: 21 LAPEDMSKEQVEEHVSRIREELDREREERNYFQ-------LERDKIHTFWEITRRQLEEK 73
L ++ Q++ V ++ L++E+E+ N + +E ++ +L E
Sbjct: 1160 LQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEV 1219
Query: 74 KAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRI 133
K EL+ K+ +++ + ++++ + K + + Q L E +A+ ++ K E
Sbjct: 1220 KKELQAKEHLVQKLQAEAD-DLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLD-EQLS 1277
Query: 134 QESVLRKDMRALK--VELKEQELASEVVVKNLRLKHTEEITRMRNDFERQ-VREIEAKYD 190
++ V ++M LK V+ KE+E+ S LK ++T + E + ++++
Sbjct: 1278 KQPVGNQEMENLKWEVDQKEREIQS--------LKQQLDLTEQQGRKELEGLQQLLQNVK 1329
Query: 191 KKMKMLRDELDLRRKTELH---EVEERKNGQIHTLMQRHEEAFTDI--------KNYYND 239
+++M +++L + +K + +V E KN + TL+Q++++ D+ K +
Sbjct: 1330 SELEMAQEDLSMTQKDKFMLQAKVSELKNN-MKTLLQQNQQLKLDLRRGAAKTRKEPKGE 1388
Query: 240 ITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLAN 299
+ +N A + + E+ L A K L LQ+ ++EM +Q+Q+
Sbjct: 1389 ASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448
Query: 300 Y 300
+
Sbjct: 1449 H 1449
Score = 30.8 bits (68), Expect = 2.8
Identities = 44/216 (20%), Positives = 93/216 (43%), Gaps = 31/216 (14%)
Query: 239 DITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLA 298
D ++++L +S E E+M + + +E + GQ + L+ +A +E +E+Q QLA
Sbjct: 388 DSICSSVSLESSAAETQEEMLQ----VLKEKMRLEGQLEALSLEASQALKEKAELQAQLA 443
Query: 299 NYERDKQILL----CTKARLKVREKELKDLQWEHEVLEQRFTKVQ--------------- 339
Q + ++ R E+ L+ LE+ T +Q
Sbjct: 444 ALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNN 503
Query: 340 --QERDELYRKFTAAIQEVQQKTGFKNLV---LERKLQALSAAVEKKEVQ---FNEVLAA 391
Q +E Y++ A ++++Q+ K+ L +++ AL + +++ +++ L A
Sbjct: 504 DLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKA 563
Query: 392 SNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQV 427
S + ++L V + + L LQ E+A +
Sbjct: 564 SQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHI 599
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 78.6 bits (192), Expect = 1e-14
Identities = 84/388 (21%), Positives = 183/388 (47%), Gaps = 51/388 (13%)
Query: 11 KAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEI----T 66
K K + + L + K +++ +V ++ +L+R + QL+ + H E+
Sbjct: 208 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 267
Query: 67 RRQLEEKKAELRNK-DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMK 125
+ Q + ++ EL N+ +++ EE R + +I+ ++K++ + + +M+ + ++ +
Sbjct: 268 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE 327
Query: 126 LAQKEHRIQESVLRKD--MRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVR 183
+K R +E + K+ +R L+ ++ EQE +++ EE + E ++R
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMHEQE----------KIREQEE----KRQEEEKIR 373
Query: 184 EIEAKYDKKMKMLRDELDLRRKTE-LHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITL 242
E E + +++ KM R E +R + E + E EE +MQ EE + +
Sbjct: 374 EQEKRQEQEAKMWRQEEKIREQEEKIREQEE--------MMQEQEEKMGEQEE------- 418
Query: 243 NNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYER 302
+ EQ E+M+++E+ + R+ ++ Q K++ + +K RE+ MQ+Q +
Sbjct: 419 -------KMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ--EEKM 469
Query: 303 DKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK--- 359
+Q + K++E+E K + E ++ EQ K +E++E R+ +QE ++K
Sbjct: 470 GEQEGKMCEQEAKMQEQEEKMRRQEEKIREQE--KKIREQEEKIREQEEMMQEQEEKMWE 527
Query: 360 TGFKNLVLERKLQALSAAVEKKEVQFNE 387
K E K+Q + ++E + E
Sbjct: 528 QEEKMCEQEEKMQEQEEKMRRQEEKMRE 555
Score = 72.8 bits (177), Expect = 6e-13
Identities = 77/318 (24%), Positives = 151/318 (47%), Gaps = 42/318 (13%)
Query: 29 EQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLE---EKKAELRNKDREME 85
+Q EE + R +EE +EREE+ Q + +KI E RRQ E EK+ ++R ++ M
Sbjct: 284 QQQEEKMWR-QEEKIQEREEK--IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 340
Query: 86 EAEER-HQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRA 144
E EE+ ++E K+++Q+ + E + + Q+E +I+E R++ A
Sbjct: 341 EKEEKIRELEEKMHEQE----------KIREQEEK-------RQEEEKIREQEKRQEQEA 383
Query: 145 LKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRR 204
+E+ E ++ E+ +M E+ + E +++ KM R E +R
Sbjct: 384 KMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE 443
Query: 205 KTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDH 264
+ + +E K + +MQ EE + + + EQ M+++E+
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGEQEG--------------KMCEQEAKMQEQEEK 489
Query: 265 LEREMAEVSGQNKRLADPLQKAREEMSEMQKQLAN-YERDKQILLCTKARLKVREKELKD 323
+ R+ ++ Q K++ + +K RE+ MQ+Q +E++++ +C + K++E+E K
Sbjct: 490 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK--MCEQEE-KMQEQEEKM 546
Query: 324 LQWEHEVLEQRFTKVQQE 341
+ E ++ EQ QQE
Sbjct: 547 RRQEEKMREQEVRLRQQE 564
Score = 65.1 bits (157), Expect = 1e-10
Identities = 64/306 (20%), Positives = 143/306 (46%), Gaps = 40/306 (13%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQ------LEEKKAELRNKD 81
+E+++E +I+E+ ++ RE+ + + + + E RRQ EEK EL K
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 82 REME---EAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVL 138
E E E EE+ Q E K+ +Q+ + Q +M + + + +K +E +
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQE------KRQEQEAKMWRQEEKIREQEEKIREQEEMMQ 407
Query: 139 RKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRD 198
++ + + E K E E+ + +++ EE R + E+++RE E K ++ +M+++
Sbjct: 408 EQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ---EKKIREQEEKIREQEEMMQE 464
Query: 199 ELDLRRKTELHEVE-ERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMED 257
+ + + E E E K + M+R EE ++EQ +
Sbjct: 465 QEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE---------------------KIREQEKK 503
Query: 258 MRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVR 317
+R++E+ + + + Q +++ + +K E+ +MQ+Q R ++ + + RL+ +
Sbjct: 504 IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQ 563
Query: 318 EKELKD 323
E+++++
Sbjct: 564 EEKMQE 569
Score = 54.7 bits (130), Expect = 2e-07
Identities = 77/398 (19%), Positives = 166/398 (41%), Gaps = 43/398 (10%)
Query: 4 KKKGKKGKAKGTPIVDGL-APEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTF 62
KKK G T G +PED K +H +R EL+ + + ++ ++
Sbjct: 75 KKKINNGTNPETTTSGGCHSPEDEQKAS-HQHQEALRRELEAQVQTIRILTCQKTELQMA 133
Query: 63 WEITRRQLEEKKAELRNKDREMEE----AEERHQVEIKVYKQK------VKHLLYEHQNN 112
++ +++ + E R+ + + A E Q V QK ++ L E
Sbjct: 134 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDAL 193
Query: 113 LTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEIT 172
E+ +L +K ++QE + + +++L +EL ++ L L +++
Sbjct: 194 SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ-QQLQ 252
Query: 173 RMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTD 232
+ ++++ + AK L+ + E +E+ R N Q M R EE +
Sbjct: 253 AEADHLGKELQSVSAK-------------LQAQVEENELWNRLNQQQEEKMWRQEEKIQE 299
Query: 233 IKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSE 292
+ + ++EQ E MR++E+ + + ++ Q + + + +K RE +
Sbjct: 300 REEKIQEQE-------EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 352
Query: 293 MQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAA 352
M +Q E++++ + K+RE+E + E E R + +E++E R+
Sbjct: 353 MHEQEKIREQEEK----RQEEEKIREQEKRQ---EQEAKMWRQEEKIREQEEKIREQEEM 405
Query: 353 IQEVQQKTGFKNLVL---ERKLQALSAAVEKKEVQFNE 387
+QE ++K G + + E ++Q + ++E + E
Sbjct: 406 MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE 443
Score = 53.1 bits (126), Expect = 5e-07
Identities = 43/200 (21%), Positives = 103/200 (51%), Gaps = 19/200 (9%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
+E++ E +IRE+ + +E+ + +K+ WE +++E++ ++R ++ ++ E
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKM---WE-QEEEMQEQEEKMRRQEEKIREQ 444
Query: 88 EER-HQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALK 146
E++ + E K+ +Q+ ++ E + + E + K+ ++E ++QE + MR +
Sbjct: 445 EKKIREQEEKIREQE--EMMQEQEEKMGEQEG------KMCEQEAKMQEQ--EEKMRRQE 494
Query: 147 VELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKT 206
+++EQE ++ + +++ EE+ M+ E+ + E +++ KM E +RR+
Sbjct: 495 EKIREQE--KKIREQEEKIREQEEM--MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 550
Query: 207 ELHEVEERKNGQIHTLMQRH 226
E +E + Q MQ H
Sbjct: 551 EKMREQEVRLRQQEEKMQEH 570
Score = 34.7 bits (78), Expect = 0.20
Identities = 29/116 (25%), Positives = 60/116 (51%), Gaps = 9/116 (7%)
Query: 24 EDMSKEQVE---EHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK 80
E+M +EQ E E ++ E+ + +E+ + + +KI +++ E++ ++R +
Sbjct: 459 EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE----QEKKIREQEEKIREQ 514
Query: 81 DREMEEAEER-HQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQE 135
+ M+E EE+ + E K+ +Q+ K E + E K V +L Q+E ++QE
Sbjct: 515 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEV-RLRQQEEKMQE 569
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 78.2 bits (191), Expect = 2e-14
Identities = 111/458 (24%), Positives = 197/458 (43%), Gaps = 81/458 (17%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEE----------KKAEL 77
K+++EE + ++ E E + Q E+ K+ + QLEE +K
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 78 RNKDREMEEAE---ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQK----- 129
K +++EE + E ++ K+ ++ + E NLTE + + + KL K
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029
Query: 130 ---EHRI--------------------------QESVLRKDMRALKVEL--KEQELAS-- 156
E R+ Q + L+ + LK++L KE+EL +
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 1089
Query: 157 -----EVVVKNLRLKHTEE----ITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTE 207
E KN+ LK E I+ ++ D E + R K +K+ + L +EL+ KTE
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESE-RASRNKAEKQKRDLGEELE-ALKTE 1147
Query: 208 LHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLER 267
L + + Q L + E+ +K TL A + + Q+++MR+K
Sbjct: 1148 LEDTLDSTAAQ-QELRSKREQEVNILKK-----TLEEEA--KTHEAQIQEMRQKHSQAVE 1199
Query: 268 EMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWE 327
E+AE Q KR+ L+KA++ + + +LAN + ++LL K E + K ++ +
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELAN---EVKVLLQGKGD---SEHKRKKVEAQ 1253
Query: 328 HEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGF--KNLVLERKLQALSAAVEKKEVQF 385
+ L+ +F + ++ R EL K T E+ TG ++ KL +A+E +
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313
Query: 386 NEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYE 423
E+L N +L S KL+ V + KNS + L+ E
Sbjct: 1314 QELLQEENRQKLSL---STKLKQVEDEKNSFREQLEEE 1348
Score = 75.9 bits (185), Expect = 8e-14
Identities = 90/433 (20%), Positives = 192/433 (44%), Gaps = 44/433 (10%)
Query: 5 KKGKKGKAKGTPIVDGLAPEDMSKEQVEE---HVSRIREELDREREERNYFQLERDKIHT 61
KK ++ +A + + A ++M+ +++ E +S ++E+L+ ER RN + ++ +
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139
Query: 62 FWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAE-G 120
E + +LE + + +E + + E+ + K+ ++ H+ + EM+ +
Sbjct: 1140 ELEALKTELE----DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
V +LA++ + + + +E + ELA+EV V L+ + R E
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV---LLQGKGDSEHKRKKVEA 1252
Query: 181 QVREIEAKYDK--------KMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTD 232
Q++E++ K+++ K+ + +++L T L + K+ ++ E D
Sbjct: 1253 QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 233 IKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSE 292
+ + L+L LK+ ++ + LE E K++A + + +
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Query: 293 MQKQLANYERDKQILLCTKARLKVREKELKDLQWEHE-------VLEQRFTKVQQERDEL 345
M+ + E +++ K +L +K+L+ L HE LE+ T++QQE D+L
Sbjct: 1373 MEDSVGCLETAEEV----KRKL---QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Query: 346 -----YRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALT 400
+++ +A E +QK F L+ E K + A E+ + A + AL+
Sbjct: 1426 LVDLDHQRQSACNLEKKQKK-FDQLLAEEKTISAKYAEERDRAE----AEAREKETKALS 1480
Query: 401 LVSRKLEDVLESK 413
L +R LE+ +E K
Sbjct: 1481 L-ARALEEAMEQK 1492
Score = 68.9 bits (167), Expect = 9e-12
Identities = 91/425 (21%), Positives = 183/425 (43%), Gaps = 61/425 (14%)
Query: 32 EEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK---DREMEEAE 88
EE + EEL + RE+ QL + T E + QL +K +L+ + + E+
Sbjct: 844 EEEMMAKEEELVKVREK----QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVE 148
E + + KQ+++ + ++ + + E E L ++ ++Q+++ + + + E
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEE---EEERCQHLQAEKKKMQQNIQELEEQLEEEE 956
Query: 149 LKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEL 208
Q+L E V +LK EE + D K K+ K+L D + T L
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQIILEDQN-------CKLAKEKKLLEDRI-AEFTTNL 1008
Query: 209 HEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 268
E EE K+ + L +HE A+I L+E++ K+ LE+
Sbjct: 1009 TE-EEEKSKSLAKLKNKHE------------------AMITDLEERLRREEKQRQELEKT 1049
Query: 269 MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLC---------TKARLKVREK 319
++ G + L+D + + + +++E++ QLA E + Q L A K+RE
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL 1109
Query: 320 E--LKDLQWEHEVLEQRFTKVQQERDELYRKF-------------TAAIQEVQQKTGFKN 364
E + +LQ + E K ++++ +L + TAA QE++ K +
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV 1169
Query: 365 LVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYEL 424
+L++ L+ + E + + + + + + A +++++ LE T+++ + EL
Sbjct: 1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL 1229
Query: 425 AQVCK 429
A K
Sbjct: 1230 ANEVK 1234
Score = 65.5 bits (158), Expect = 1e-10
Identities = 111/493 (22%), Positives = 220/493 (44%), Gaps = 79/493 (16%)
Query: 28 KEQVEEHVSRIREELDRERE--ERNYFQLERDK-IHTFWEITRRQLEEKKAELRNKDREM 84
+E+ + H ++I+E + + E QLE+ K + E ++ LE ++ EL N+ + +
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 85 -----EEAEERHQVEIKVYKQKVK-----HLLYEHQNNLTEMKAE-GTVVMKLAQKEHRI 133
+ +R +VE ++ + +VK + E + +T+++ E V L+Q + +
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK- 1295
Query: 134 QESVLRKDMRALKVELKE-QELASEVVVKNLRLK-HTEEITRMRNDFERQVREIE-AKY- 189
S L KD AL+ +L++ QEL E + L L +++ +N F Q+ E E AK+
Sbjct: 1296 -SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN 1354
Query: 190 -DKKMKMLRDEL-DLRRKTE--------LHEVEERKNGQIHTLMQRHEE---AFTDIKNY 236
+K++ L ++ D+++K E EV+ + + L QRHEE A+ ++
Sbjct: 1355 LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414
Query: 237 YNDITLNNLALINSLKEQME---DMRKKE---DHL-------------EREMAEVSGQNK 277
+ L+ L Q + ++ KK+ D L ER+ AE + K
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 278 R-----LADPLQKAREEMSEMQKQLANYERDKQILLCTKARL--KVREKELKDLQWEHEV 330
LA L++A E+ +E+++ + + + L+ +K + V E E E +V
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV 1534
Query: 331 LEQRFTKVQQERDELY-----------------RKFTAAIQEVQQKTGFKNLVLERKLQA 373
E + T++++ DEL +F +Q +++ K L R+++
Sbjct: 1535 EEMK-TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE 1593
Query: 374 LSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQV--CKAH 431
+ A +E + Q + +AA L + ++ ++++ IK L+ AQ+ C
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653
Query: 432 NDLLRTYEAKLLA 444
D R ++LA
Sbjct: 1654 LDDTRASREEILA 1666
Score = 50.4 bits (119), Expect = 3e-06
Identities = 60/349 (17%), Positives = 152/349 (43%), Gaps = 27/349 (7%)
Query: 24 EDMSKEQVEEHVSRIRE---ELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK 80
++ S+E+ ++ V ++RE EL+ ER++R+ R K+ L++ +A + +
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM-------DLKDLEAHIDSA 1629
Query: 81 DREMEEAEE---RHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESV 137
++ +EA + + Q ++K +++ + L + K + + + ++QE +
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689
Query: 138 LRKDMRALKVELKEQELASEVVVKN----LRLKHTEEITRMRNDFERQVREIEAKYD--- 190
+ + + + ELA E+ + L L+ + E ++ E + +
Sbjct: 1690 AAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN 1749
Query: 191 ---KKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL 247
KK + D+++ E ++ +N + L ++++E ++ + A
Sbjct: 1750 DRLKKANLQIDQINTDLNLERSHAQKNENAR-QQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 248 INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQIL 307
I +L+ ++ + E+ L+ E E K++ +K ++ + ++ + N E+ K
Sbjct: 1809 ITALEAKIAQL---EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA 1865
Query: 308 LCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEV 356
RLK +++L++ + E + K+Q+E ++ A +EV
Sbjct: 1866 DKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREV 1914
Score = 46.6 bits (109), Expect = 5e-05
Identities = 75/344 (21%), Positives = 139/344 (40%), Gaps = 60/344 (17%)
Query: 101 KVKHLLYEHQNNLTEMKAEGTVVMKLAQK----EHRIQE-SVLRKDMRALKVELKEQ--- 152
KVK LL + EM A+ ++K+ +K E+R+ E L+ + A K++L+EQ
Sbjct: 833 KVKPLLQVSRQE-EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891
Query: 153 --ELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHE 210
EL +E RL T + + E ++EA+ +++ + + H
Sbjct: 892 ETELCAEAEELRARL------TAKKQELEEICHDLEARVEEEEERCQ-----------HL 934
Query: 211 VEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMA 270
E+K Q + +Q EE + ++ + L + LK+ LE E
Sbjct: 935 QAEKKKMQQN--IQELEEQLEEEESARQKLQLEKVTTEAKLKK-----------LEEEQI 981
Query: 271 EVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEV 330
+ QN +LA + + ++E L E + K L L+ +HE
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE--------------KSKSLAKLKNKHEA 1027
Query: 331 ----LEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFN 386
LE+R + +++R EL K ++ + L+ ++ L + KKE +
Sbjct: 1028 MITDLEERLRREEKQRQEL-EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 387 EVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKA 430
LA + A + +K+ ++ + +DL+ E A KA
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 77.8 bits (190), Expect = 2e-14
Identities = 90/347 (25%), Positives = 162/347 (46%), Gaps = 44/347 (12%)
Query: 30 QVEEHVSRIREELD-----REREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREM 84
Q EE R R+ L RE+ ER ER + + + E+++ + R +++E+
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 85 EEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMR- 143
+ EE Q++ + Q+ L E ++ L E + + ++ R Q RK R
Sbjct: 832 QFLEEEEQLQRRERAQQ----LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887
Query: 144 ------ALKVEL-KEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKML 196
AL+ +L KEQ+L E + L+ E R R + ERQ RE E ++ ++L
Sbjct: 888 TLYAKPALQEQLRKEQQLLQE---EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 197 RDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQME 256
R+E + RR+ E ER+ + L Q+ E+ + + + E
Sbjct: 945 REEREKRRRQE----RERQYRKDKKLQQKEEQLLGE------EPEKRRRQEREKKYREEE 994
Query: 257 DMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKV 316
+++++E+ L RE E + ++ + + ++E+ + ++QL ER+K+ RL+
Sbjct: 995 ELQQEEEQLLRE--EREKRRRQEWERQYRKKDELQQEEEQLLREEREKR-------RLQE 1045
Query: 317 RE---KELKDLQWEHEVL--EQRFTKVQQERDELYRKFTAAIQEVQQ 358
RE +E ++LQ E E L E+R T+ +QE + YRK QE +Q
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Score = 77.0 bits (188), Expect = 3e-14
Identities = 84/349 (24%), Positives = 165/349 (47%), Gaps = 29/349 (8%)
Query: 19 DGLAPE-DMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAEL 77
DGL + + + Q + + R +L+ ER+ R + + + ++ L+E++ EL
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Query: 78 RNKDRE--MEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTV--VMKLAQKEHRI 133
+ ++RE + +ER E + +Q+ + LL E + + E KL QKE ++
Sbjct: 914 QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL 973
Query: 134 --QESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDK 191
+E R+ K +E+EL E +L E R R ++ERQ R+ + +
Sbjct: 974 LGEEPEKRRRQEREKKYREEEELQQE----EEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 192 KMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSL 251
+ ++LR+E + RR E ER+ + L Q E+ + + T L
Sbjct: 1030 EEQLLREEREKRRLQE----RERQYREEEELQQEEEQLLGEERE-----TRRRQELERQY 1080
Query: 252 KEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTK 311
+++ E+++++E+ L RE E + +R + + EE+ + ++QL ER+K+ +
Sbjct: 1081 RKE-EELQQEEEQLLREEPEKRRRQER--ERQCREEEELQQEEEQLLREEREKR----RR 1133
Query: 312 ARLKVREKELKDLQWEHEVL--EQRFTKVQQERDELYRKFTAAIQEVQQ 358
L+ + +E +++Q E E L E+ + +QE + YR+ QE +Q
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Score = 73.6 bits (179), Expect = 4e-13
Identities = 88/405 (21%), Positives = 181/405 (44%), Gaps = 42/405 (10%)
Query: 21 LAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK 80
L E+ K + +E + R++ + ++EE + ER+K E R+ EE++ + +
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK-RRLQERERQYREEEELQQEEE 1061
Query: 81 DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEM--KAEGTVVMKLAQKEHRIQ---E 135
EE E R + E++ +K + L E + L E K + ++E +Q E
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 136 SVLRKDM-----RALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYD 190
+LR++ + L+ + +E+E EV + +L E R R + ERQ RE E
Sbjct: 1122 QLLREEREKRRRQELERQYREEE---EVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 191 KKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRH--EEAFTDIK--------NYYNDI 240
++ ++LR+E + RR+ + E + Q QR+ E+ +D+K N D
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN 1238
Query: 241 TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQ----------------NKRLADPLQ 284
+ N Q+ED + ++ ++++ + G+ ++ + Q
Sbjct: 1239 KVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ 1298
Query: 285 KAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKV--QQER 342
REE E +++ + +KQ+L + + R++ + + E ++L++R + +QER
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 343 DELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNE 387
D +R+ QE +K + L R+ + E+++++ E
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE 1403
Score = 73.2 bits (178), Expect = 5e-13
Identities = 81/340 (23%), Positives = 151/340 (44%), Gaps = 42/340 (12%)
Query: 21 LAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK 80
L E +EQ ++ + R ++ ++ EER Q ER + E +Q E ++ +LR +
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ---ERREQQEERREQQLRRE 342
Query: 81 DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRK 140
E E + R + E + +Q+++ E + E + ++ Q+ R Q+ +
Sbjct: 343 QEERREQQLRREQEEERREQQLRR---EQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 141 DMRALKVELKEQELASEVVVK---NLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLR 197
+R + +EQ+L E ++ LR + EE +++ ER+ + ++ + +++ R
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER----R 455
Query: 198 DELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMED 257
D L +TE HE E RK + E + ++ +E+ E
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE----------------EERREQ 499
Query: 258 MRKKEDHLEREMAEVSGQ-------NKRLADPL---QKAREEMSEMQKQLANYERDKQI- 306
++E L RE E Q +RL L Q+ R E E ++QL E +K++
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 307 LLCTKARLKVREKELKD--LQWEHEVLEQRFTKVQQERDE 344
+ RLK ++E +D L+ E E +QR + Q+ER E
Sbjct: 560 QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Score = 73.2 bits (178), Expect = 5e-13
Identities = 83/341 (24%), Positives = 157/341 (46%), Gaps = 45/341 (13%)
Query: 21 LAPEDMSKEQVEEHVSRIREELDRE-REERNYFQLERDKIHTFWEITRRQLEE----KKA 75
L E+ + Q EE R R+E +R+ REE Q E + E RRQ E K
Sbjct: 905 LLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 76 ELRNKDREM--EEAEERHQVEIKVYKQKVKHLLYEHQNNLTE-----MKAEGTVVMKLAQ 128
+L+ K+ ++ EE E+R + E + ++ + L E + L E + E +
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 129 KEHRIQESVLRKDMRALKVELKEQEL--ASEVVVKNLRLKHTEEITRMRNDFERQVREIE 186
+ + +E +LR++ +++ +E++ E+ + +L E TR R + ERQ R+ E
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 187 AKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLA 246
++ ++LR+E + RR+ E ER+ + L Q E+
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQE----RERQCREEEELQQEEEQL----------------- 1123
Query: 247 LINSLKEQMEDMRKKE-DHLEREMAEVSGQNKRL--ADPLQKAREEMSEMQKQLANYERD 303
L+E+ E R++E + RE EV + ++L +P ++ R+E+ ++ +++
Sbjct: 1124 ----LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 304 KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE 344
++ LL + + +E+E Q+ E QR + Q+ RDE
Sbjct: 1180 EEQLLREEQEKRRQERE---RQYREEEELQRQKRKQRYRDE 1217
Score = 70.1 bits (170), Expect = 4e-12
Identities = 82/364 (22%), Positives = 167/364 (45%), Gaps = 35/364 (9%)
Query: 24 EDMSKEQVEEHVSR---IREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK 80
+ + ++Q EE R + EE RE++ER QL R++ + +RQ EE++ + R +
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 81 D-----REMEE-------AEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQ 128
RE EE EE ++E + +Q++K E ++ L + + E +
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593
Query: 129 KEHRIQESVLRKDMRAL-KVELKEQELASEVVVKNLR---LKHTEEITRMRNDFERQVRE 184
+E R+++ + R+++ L + E +EQ L E + R LK E+ R + R+ +E
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 185 IEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKN-------YY 237
+ ++++K +E L ++ + EER+ ++ + E+A IK+
Sbjct: 654 ---RREQRLKREEEEERLEQRLKREHEEERREQEL--AEEEQEQARERIKSRIPKWQWQL 708
Query: 238 NDITLNNLALINSLKEQMEDMRKKEDHLE---REMAEVSGQNKRLADPLQKAREEMSEMQ 294
+ + S + E R++++ E R +E+ Q + A Q+ E+ +
Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768
Query: 295 KQLANYERDKQILLCTKARLKVREKELKDLQ-WEHEVLEQRFTKVQQERDELYRKFTAAI 353
Q E+ ++ AR +RE+ + L+ E + EQRF ++E+++ R+
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 354 QEVQ 357
+E+Q
Sbjct: 829 KELQ 832
Score = 69.7 bits (169), Expect = 5e-12
Identities = 84/377 (22%), Positives = 167/377 (44%), Gaps = 51/377 (13%)
Query: 25 DMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREM 84
D +Q +H+ ++E DRE+E R + Q +R F E + + EE+K E + +DR+
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRH----FPEEEQLEREEQK-EAKRRDRKS 1314
Query: 85 EEAEE--RHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDM 142
+E ++ R + E K +Q+ E + L E + + ++ +++ + +E LR
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP---LRRQERDRKFREEELRHQE 1371
Query: 143 RALKV-----ELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIE---AKYDKKMK 194
+ K L+ QE + + + +L+ E ++R D +R+ RE E ++ ++ K
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 195 MLRDELDLRRKT----------ELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNN 244
+E +RR+ +L + RK + L+Q EE + + +
Sbjct: 1432 FREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ----QLHRQERDRKF 1487
Query: 245 LALINSLKEQMEDMRKKEDHL------------EREMAEVSGQNKRLADPLQKAREEMSE 292
L L+ Q D + +E L E+++ Q K L + Q R+E +
Sbjct: 1488 LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Query: 293 MQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAA 352
++Q +RD++ + R +E+E + L + + R + + R E RKF
Sbjct: 1548 QRRQ----DRDRKFREEEQLR---QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 353 IQEVQQKTGFKNLVLER 369
Q+++++ G + L ER
Sbjct: 1601 EQQLRRQEGQQQLRQER 1617
Score = 68.9 bits (167), Expect = 9e-12
Identities = 76/363 (20%), Positives = 162/363 (44%), Gaps = 11/363 (3%)
Query: 24 EDMSKEQVEEHVSRIREELDRE-REERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDR 82
E+ +++ E +EE ++E R+ + E +K+ +R+L+E++ +LR +R
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 83 EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDM 142
+ E + + + + ++ + L + + E + E + +++ +E LR++
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ 343
Query: 143 RALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDL 202
+ + +E E + LR + EE + E+Q+R + ++ + LR E L
Sbjct: 344 EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL--RREQQLRREQQL 401
Query: 203 RRKTEL-HEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKK 261
RR+ +L E + R+ Q+ Q E + ++ L +E+ D K+
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE-QEERRDWLKR 460
Query: 262 EDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKEL 321
E+ ER E Q + D ++ RE +++++ +++++ + + + RE+ L
Sbjct: 461 EEETERHEQERRKQQLK-RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 322 KDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKK 381
K Q E E L+QR QQ R E + ++ ++ K L ER+ Q L E++
Sbjct: 520 K-RQEEEERLQQRLRSEQQLRREQEERREQLLKREEE----KRLEQERREQRLKREQEER 574
Query: 382 EVQ 384
Q
Sbjct: 575 RDQ 577
Score = 65.9 bits (159), Expect = 8e-11
Identities = 84/366 (22%), Positives = 163/366 (44%), Gaps = 47/366 (12%)
Query: 16 PIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKA 75
P + L E+ + + + S+ ++L RE E + E D+ E ++ EE+
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 76 ELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQE 135
+ +DR+ E E RHQ + + + E + L + E + + Q + +E
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKF--------LEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Query: 136 SVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVR--EIEAKYDKKM 193
LR+D R K +EQ+L+ +E R + E+QVR E E K+ ++
Sbjct: 1406 QQLRQD-RDRKFREEEQQLS------------RQERDRKFREEEQQVRRQERERKFLEEE 1452
Query: 194 KMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTD----IKNYYNDITLNNLALIN 249
+ LR E + + E ++ER+ Q+H Q + F + ++ D L +
Sbjct: 1453 QQLRQERHRKFREEEQLLQEREEQQLH--RQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 250 SLKE--------QMEDMRKKEDHLEREM---AEVSGQNKRLADPLQKAREE----MSEMQ 294
E Q+ +++ L+ E + GQ +R D +K REE +
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR-QDRDRKFREEEQLRQEREE 1569
Query: 295 KQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQR-FTKVQQERDELYRKFTAAI 353
+QL+ ERD++ L + +++ +E+E K ++ E ++ Q +++QERD +R+ +
Sbjct: 1570 QQLSRQERDRKFRL-EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628
Query: 354 QEVQQK 359
QE +++
Sbjct: 1629 QEREEQ 1634
Score = 65.1 bits (157), Expect = 1e-10
Identities = 86/379 (22%), Positives = 169/379 (44%), Gaps = 38/379 (10%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDRE 83
E+ +EQ EE R ++E ++EER QL R++ + RR+ EE++ E + + RE
Sbjct: 311 EEERREQQEER--REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLR-RE 367
Query: 84 MEEAEERHQVEIKVYKQKVKHLLYEHQ-NNLTEMKAEGTV--VMKLAQKEHRIQESVLRK 140
EE Q+ + ++ + L E Q +++ E + +L +++ +E LR+
Sbjct: 368 QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427
Query: 141 DMRALKVELK------EQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMK 194
+ + E K EQ L E + LK EE R + +Q + + + +++ +
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 195 MLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNN-LALINSLKE 253
L+ E + RR E +ER+ Q+ + E +K + L L L+
Sbjct: 488 WLKLEEEERR-----EQQERREQQLRREQEERREQ--RLKRQEEEERLQQRLRSEQQLRR 540
Query: 254 QMEDMRKK------EDHLEREMAE--VSGQNKRLADPLQKAREEMSEMQKQLANYERDKQ 305
+ E+ R++ E LE+E E + + + D L K EE + + + ER +Q
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 306 ILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNL 365
+++ +E++ L+ E E EQR + + E + + + QE +++ +
Sbjct: 601 ---------RLKREEVERLEQE-ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 366 VLERKLQALSAAVEKKEVQ 384
ER+ Q L E++ ++
Sbjct: 651 QQERREQRLKREEEEERLE 669
Score = 64.7 bits (156), Expect = 2e-10
Identities = 94/391 (24%), Positives = 183/391 (46%), Gaps = 43/391 (10%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERN--YFQLERDKIHTFWEITRRQLEEK-KAELRNK 80
E + + ++ E + REE ++R ER FQ E +K E R+ EEK + E +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 81 DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRK 140
RE++E EE+ + K+ +Q+++ E + ++ E + K Q+E R ++ R+
Sbjct: 268 QRELQEEEEQLR---KLERQELRRERQEEEQQQQRLRREQQLRRK--QEEERREQQEERR 322
Query: 141 DM---RALKVELKEQELASEVVVKN---LRLKHTEEIT--RMRNDFERQVREIEAKYDKK 192
+ R + E +EQ+L E + LR + EE ++R + E + RE + + +++
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 193 MK---MLRDELDLRRKTELHEVEE-RKNGQIHTLMQ--RHEEAFTDIKNYYNDITLNNLA 246
++ LR E LRR+ +L ++ R+ Q+ Q R ++ + + ++
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 247 LINSLKEQMEDMR---KKEDHLEREMAEVSGQN----------KRLADPLQKAREEMSEM 293
LK + E+ R K+E+ ER E Q +R ++ R E E
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502
Query: 294 QKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE--LYRKFTA 351
++Q E++++ + RLK R++E + LQ + EQ+ + Q+ER E L R+
Sbjct: 503 REQQLRREQEER----REQRLK-RQEEEERLQ-QRLRSEQQLRREQEERREQLLKREEEK 556
Query: 352 AIQEVQQKTGFKNLVLERKLQALSAAVEKKE 382
+++ +++ K ER+ Q L E+++
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQ 587
Score = 63.9 bits (154), Expect = 3e-10
Identities = 86/362 (23%), Positives = 163/362 (45%), Gaps = 34/362 (9%)
Query: 23 PEDMSKEQV---EEHVSRIREELDREREERNYFQLERDKIHTFWEIT-RRQLEEKKAELR 78
PE+ ++Q+ EE R +++L RE++ER +L+R++ E +R+ EE++ E
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 79 NKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEM--KAEGTVVMKLAQKEHRIQES 136
+ E E+A ER + I ++ +++ Q+ + K EG + +++ R +ES
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 137 VLR--KDMRALKVELKEQ-----------ELASEVVVKNLRLKHT--EEITRMRNDFERQ 181
L+ ++ RA + + +E+ E SE + L + E+ R ERQ
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ 804
Query: 182 VREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDIT 241
RE +++ K R R+ EL +EE + Q Q+ +E ++
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 242 LNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYE 301
+ Q+E+ RK+ H L + L+K ++ + E +++L E
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRH-------TLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 302 RDKQILLCTKARLKVREKELKDLQWEHEVL--EQRFTKVQQERDELYRKFTAAIQEVQQK 359
R+K+ + + + +E + LQ E E L E+R + +QER+ YRK Q+ +Q
Sbjct: 918 REKR----RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL 973
Query: 360 TG 361
G
Sbjct: 974 LG 975
Score = 62.4 bits (150), Expect = 9e-10
Identities = 83/368 (22%), Positives = 168/368 (45%), Gaps = 60/368 (16%)
Query: 32 EEHVSRIREELDRE-REERNYFQLERDKIHTFWEITRRQ-----------LEEKKAELRN 79
EE R R+EL+R+ REE Q E + E RRQ L++++ +L
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 80 KDRE--MEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMK-----------AEGTVVMKL 126
+++E +E E +++ E ++ +QK K Y ++ +++K + V K
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQ-RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 127 AQKE--HRIQESVLR-----KDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFE 179
+ E ++++S LR +D++ L E +E++ E R +H E ++ + +
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 180 RQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYND 239
++ + + K ++ ++LR+E + +R+ + +RK + L+Q EE ++ D
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRR---RQETDRKFREEEQLLQEREE--QPLRRQERD 1359
Query: 240 ITLNNLALINSLKEQMEDMRKKEDHLEREMAE----VSGQNKRLADPLQKAREE----MS 291
L + +EQ ++E L R+ E Q R + Q+ R++
Sbjct: 1360 RKFREEELRH--QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 292 EMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTA 351
E ++QL+ ERD+ + + E++++ + E + LE+ QQ R E +RKF
Sbjct: 1418 EEEQQLSRQERDR--------KFREEEQQVRRQERERKFLEEE----QQLRQERHRKFRE 1465
Query: 352 AIQEVQQK 359
Q +Q++
Sbjct: 1466 EEQLLQER 1473
Score = 60.5 bits (145), Expect = 3e-09
Identities = 67/330 (20%), Positives = 139/330 (42%), Gaps = 38/330 (11%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
K + +E + E+ + R + QL +++ F E + E ++ +L ++R+ +
Sbjct: 1587 KVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646
Query: 88 EERHQVEIKVYKQKVKH---LLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRA 144
EE Q+ + +Q+++H + + L + E + + ++ R +E LR+ R
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706
Query: 145 LKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRR 204
K +EQ+L + + + R + + RQ R + +++++ R+E LRR
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766
Query: 205 KTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDH 264
+ +RK + L Q EE L+ Q D + +E+
Sbjct: 1767 -----QERDRKFREEEQLRQEREE--------------------QQLRSQESDRKFREEE 1801
Query: 265 LEREMAEVSGQNKRLADPLQKAREEMSEM--QKQLANYERDKQI----LLCTKARLKVRE 318
R+ E + D + EE ++ Q+Q ERD+Q T+ + + E
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Query: 319 KELKDLQWEHEVLEQRFTKVQQERDELYRK 348
+EL W+ E ++R + ++ R+E R+
Sbjct: 1862 QEL----WQEEEQKRRQERERKLREEHIRR 1887
Score = 60.1 bits (144), Expect = 4e-09
Identities = 69/348 (19%), Positives = 149/348 (42%), Gaps = 25/348 (7%)
Query: 4 KKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFW 63
+++ +K + + + +G + + + R EEL R+R+E W
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQE--------------W 180
Query: 64 EITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV 123
+ + E++ K E EE + Q+ + + + E Q E + V
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE--RQDRVF 238
Query: 124 MKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVR 183
+ +KE R +E+VLRK+ L+ E +++ + + LR +E+ R R + E+Q +
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 184 EIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLN 243
+ + +++++ ++E ++ E E +ER+ Q +R E+ + + L
Sbjct: 299 RL--RREQQLRRKQEEERREQQEERREQQERREQQ----EERREQQLRREQEERREQQLR 352
Query: 244 NLALINSLKEQM---EDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 300
++Q+ ++ ++E L RE Q R L++ ++ E Q +
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 301 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRK 348
R +Q L + + +E+E + + E E EQR + Q+ER + ++
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR 460
Score = 58.9 bits (141), Expect = 1e-08
Identities = 70/341 (20%), Positives = 147/341 (43%), Gaps = 30/341 (8%)
Query: 24 EDMSKEQVEEHVSRIREE--LDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKD 81
E + K + E+ + + R E L RE+EER L+R++ + R Q E + L+ ++
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 82 REMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKD 141
E E EER + Q++K E + +K+E ++E R Q+ + R+
Sbjct: 607 VERLEQEERRE-------QRLKREEPEEERRQQLLKSE--------EQEERRQQQLRREQ 651
Query: 142 MRALKVELKEQELASEVVVKNLRLKHTEEITR--MRNDFERQVRE-IEAKYDKKMKMLRD 198
+ LK +E E + + L+ +H EE + + + Q RE I+++ K L
Sbjct: 652 QERREQRLKREE-EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 199 ELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDM 258
E D R+ ++++ ++ GQ Q + + + + + Q ++
Sbjct: 711 EADARQ-SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE--------ERAHRQQQEE 761
Query: 259 RKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVRE 318
++ D + AE + R + E E Q + ++ +Q L + + R
Sbjct: 762 EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821
Query: 319 KELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK 359
++ ++ + E + LE+ ++ER + ++ +QE Q++
Sbjct: 822 RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Score = 58.9 bits (141), Expect = 1e-08
Identities = 80/329 (24%), Positives = 149/329 (45%), Gaps = 51/329 (15%)
Query: 24 EDMSKEQVEEHVSRIREELDRE--REERNYFQLERDKIHTFWEITRRQLEEKKAELRNKD 81
E + +E+ E+ + R +E DR+ EE+ + ERD+ + ++ ELR+++
Sbjct: 1467 EQLLQEREEQQLHR--QERDRKFLEEEQQLRRQERDR------------KFREQELRSQE 1512
Query: 82 REMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKD 141
E + EE Q+ +Q+ + L E Q +++ + + ++ + +E
Sbjct: 1513 PERKFLEEEQQLH---RQQRQRKFLQEEQ----QLRRQERGQQRRQDRDRKFREE----- 1560
Query: 142 MRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKK--MKMLRDE 199
L+ E +EQ+L+ + + RL EE R + ER+ E E + ++ + LR E
Sbjct: 1561 -EQLRQEREEQQLSRQERDRKFRL---EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Query: 200 LDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMR 259
D + + + ++ER+ Q+H R E D K + L L+ +
Sbjct: 1617 RDRKFREDEQLLQEREEQQLH----RQER---DRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 260 KKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREK 319
++E+ L +E E Q R + +K REE ++QL ER+++ L + ++R +
Sbjct: 1670 REEEQLLQEGEE---QQLRRQERDRKFREE----EQQLRRQERERKFL---QEEQQLRRQ 1719
Query: 320 ELKDLQWEHEVLEQRFTKVQQERDELYRK 348
EL+ E E L Q + Q R E YRK
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRK 1748
Score = 58.5 bits (140), Expect = 1e-08
Identities = 81/385 (21%), Positives = 163/385 (42%), Gaps = 42/385 (10%)
Query: 21 LAPEDMSKEQVEEHVSRIREELDREREERNYF-QLERDKIHTFWEITRRQ-LEEKKAELR 78
L E + Q E R EEL R++ ++ Y + +R + WE + + + K +
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243
Query: 79 NKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKA-----------EGTVVMKLA 127
++ E E Q+ + +Q ++HLL E Q E + E + +
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE 1303
Query: 128 QKEHRIQESVLRKDMRALKVELKEQELASEVVVK----NLRLKHTEEITRMRNDFERQVR 183
QKE + ++ +++ + L+ E +E+ E K L+ EE R + +R+ R
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363
Query: 184 EIEAKYDKK-MKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITL 242
E E ++ ++ K L +E LRR+ E + K Q +R ++ D + +
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQER--ERKFLKEEQQLRCQEREQQLRQDRDRKFRE--- 1418
Query: 243 NNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYER 302
E+ + R++ D RE Q R + +K EE +++++ R
Sbjct: 1419 ----------EEQQLSRQERDRKFRE----EEQQVRRQERERKFLEEEQQLRQERHRKFR 1464
Query: 303 DKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGF 362
+++ LL + E++L + + + LE+ +QERD +R+ QE ++K
Sbjct: 1465 EEEQLLQER-----EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 363 KNLVLERKLQALSAAVEKKEVQFNE 387
+ L R+ + E+++++ E
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQE 1544
Score = 50.8 bits (120), Expect = 3e-06
Identities = 72/315 (22%), Positives = 135/315 (42%), Gaps = 37/315 (11%)
Query: 68 RQLEEKKAELR-----NKDREMEEAEERHQVEIKVY---KQKVKHLLYEHQNNLTEMKAE 119
RQLEE+ + R ++RE+ E EE+ + + ++ +Q+ L+ + E
Sbjct: 127 RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE---- 182
Query: 120 GTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFE 179
++E R +E L+ E ++E + LR K EE + R E
Sbjct: 183 --------REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRR--E 232
Query: 180 RQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYND 239
RQ R + + +K+ + + E LR++ E + EE Q +Q EE ++
Sbjct: 233 RQDRVFQEEEEKEWR--KRETVLRKEEEKLQEEE---PQRQRELQEEEEQLRKLER---- 283
Query: 240 ITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLAN 299
L +EQ + ++E L R+ E + + Q+ RE+ E ++Q
Sbjct: 284 ---QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 300 YERD--KQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQ 357
E++ ++ L + + RE++L+ Q E E EQ+ + QQ R E + ++ Q
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQ-EEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 358 QKTGFKNLVLERKLQ 372
Q + L E++L+
Sbjct: 400 QLRREQQLRREQQLR 414
Score = 41.2 bits (95), Expect = 0.002
Identities = 49/210 (23%), Positives = 83/210 (39%), Gaps = 29/210 (13%)
Query: 21 LAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNK 80
L E + Q E R E+L +E E+ + ER + E R + EE++ + +
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER 1769
Query: 81 DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRK 140
DR+ E E+ Q E + + + Q +E LR
Sbjct: 1770 DRKFREEEQLRQ---------------EREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Query: 141 DMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDEL 200
R K +E++L E E+ R+R + +RQ R E ++ + K R+E
Sbjct: 1815 QQRDGKYRWEEEQLQLE-----------EQEQRLRQERDRQYR-AEEQFATQEKSRREEQ 1862
Query: 201 DLRRKTE--LHEVEERKNGQIHTLMQRHEE 228
+L ++ E + ERK + H Q+ EE
Sbjct: 1863 ELWQEEEQKRRQERERKLREEHIRRQQKEE 1892
Score = 36.6 bits (83), Expect = 0.052
Identities = 39/168 (23%), Positives = 79/168 (47%), Gaps = 21/168 (12%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDRE 83
E + Q + R E+L +EREE+ E D+ F E + + E ++ +LR + R+
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR--KFREEEQLRQEREEQQLRPQQRD 1818
Query: 84 MEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMR 143
+ E Q++++ +Q+++ Q + +AE Q++ R +E L ++
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLR------QERDRQYRAEEQFA---TQEKSRREEQELWQEEE 1869
Query: 144 ALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDK 191
+ + +E++L E ++R + EE RQV EI+++ K
Sbjct: 1870 QKRRQERERKLREE----HIRRQQKEE------QRHRQVGEIKSQEGK 1907
Score = 33.5 bits (75), Expect = 0.44
Identities = 22/90 (24%), Positives = 47/90 (52%), Gaps = 5/90 (5%)
Query: 19 DGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLE----RDKIHTFWEITRRQLEEKK 74
DG + + Q+EE R+R+E DR+ F + R++ + E +++ +E++
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877
Query: 75 AELRNKD-REMEEAEERHQVEIKVYKQKVK 103
+LR + R ++ E+RH+ ++ Q+ K
Sbjct: 1878 RKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Score = 29.3 bits (64), Expect = 8.2
Identities = 28/145 (19%), Positives = 64/145 (44%), Gaps = 14/145 (9%)
Query: 252 KEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYER--------- 302
+EQ ++ + E+ E++ +R + L + R+E E +++ A E+
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 303 ---DKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK 359
+ L + L++R K ++ Q + + R Q+E ++ +RK +++ ++K
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV--FQEEEEKEWRKRETVLRKEEEK 259
Query: 360 TGFKNLVLERKLQALSAAVEKKEVQ 384
+ +R+LQ + K E Q
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQ 284
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 77.0 bits (188), Expect = 3e-14
Identities = 98/436 (22%), Positives = 195/436 (44%), Gaps = 57/436 (13%)
Query: 24 EDMSKEQVEEHVSRIRE-ELDREREERNYFQLERDKIHTFWEITR-RQLEEKKAELRNKD 81
+++SK+ ++E + E RE ER LE++ H ++ RQ + AE R KD
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 82 REMEEAEERHQVE--------IKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRI 133
E E ++ I+ K+++K L EH E E + +KE+ +
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLEKENEL 643
Query: 134 -QESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKK 192
Q+ + + K+E EQE SE+ +N +LK T + F+ ++E+ +
Sbjct: 644 LQKKITNLKITCEKIEALEQE-NSELERENRKLKKTLD------SFKNLTFQLESLEKEN 696
Query: 193 MKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLK 252
++ + L+LRR E + K Q+ + E +K
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL--------------- 741
Query: 253 EQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKA 312
E ++ KK + LE + +N+RL L+ + +++ +++ +L + E + Q L
Sbjct: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
Query: 313 RLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQ--EVQQKTGFKNLV---- 366
LK+ K L+ L+ E++ LEQ +++++++ +L ++ Q E++ T +N V
Sbjct: 802 ELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861
Query: 367 LERKLQALSAAV----------EKKEVQFNEVLAASNLDPAALT-----LVSRKLEDVLE 411
LE++ + LS + ++ E + E++ + +D L LVS KL+ +
Sbjct: 862 LEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK--TQ 919
Query: 412 SKNSTIKDLQYELAQV 427
N+ ++ L +EL ++
Sbjct: 920 QMNNDLEKLTHELEKI 935
Score = 68.9 bits (167), Expect = 9e-12
Identities = 90/433 (20%), Positives = 186/433 (42%), Gaps = 61/433 (14%)
Query: 29 EQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAE 88
EQ+E+ + +E + +++ + E ++ EI LEE ++ N ++E +
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVE 148
+ EI +YK+ L E++ E ++K A ++ K + L+ +
Sbjct: 871 K----EIGIYKESCVRL--------KELEKENKELVKRA--------TIDIKTLVTLRED 910
Query: 149 LKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEL 208
L ++L ++ + +L K T E+ ++ + ER + + ++ D + K+L +L+ K L
Sbjct: 911 LVSEKLKTQQMNNDLE-KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969
Query: 209 HEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 268
E++E K I L R EE+ YN L + E ++ R+ E+ + +
Sbjct: 970 -EIKEEK---IAALEARLEESTN-----YNQQLRQELKTVKKNYEALKQ-RQDEERMVQS 1019
Query: 269 MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK------ 322
+SG++ + Q+ E+ +++ +L ER+ L K LK + K+L+
Sbjct: 1020 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1079
Query: 323 ------------DLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERK 370
LQ ++ L+ + K+Q E L + T+ + + Q L+ +
Sbjct: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL-----LIQQSS 1134
Query: 371 LQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLE---SKNSTI----KDLQYE 423
L+ + +V K+ + + D L L+ + E SK+ T+ K+L+ E
Sbjct: 1135 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1194
Query: 424 LAQVCKAHNDLLR 436
+ +N LL+
Sbjct: 1195 HRDLEDRYNQLLK 1207
Score = 60.5 bits (145), Expect = 3e-09
Identities = 77/386 (19%), Positives = 177/386 (45%), Gaps = 54/386 (13%)
Query: 44 REREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVK 103
+ E R + +E R++LEEK +L + +E+E+ E +E+K +Q+
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQME----IELKRLQQENM 296
Query: 104 HLLYE------HQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASE 157
+LL + +++ L ++ + V KL + R +E + D+ K ++E + ++
Sbjct: 297 NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL--HDIEFYKARVEELKEDNQ 354
Query: 158 VVVK-NLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKN 216
V+++ L+ E TR R+D ++ + + K+ + E D+ RK +EE
Sbjct: 355 VLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT 414
Query: 217 -------------------GQIHTLMQRHEEAFTDIKNYYNDITLNNLALI----NSLKE 253
QI + E + + N++T + L + SL +
Sbjct: 415 LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTK 474
Query: 254 QMEDMRKKEDHLE---REMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCT 310
+E++R D +E ++ ++ +N+RL+ ++ E+ + ++ L N + + L+
Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
Query: 311 KARLKV--------REKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGF 362
KA+L+ E+++K L+ E+E L Q + ++Q R ++ + A ++++++
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISAE--ARVKDIEK---- 587
Query: 363 KNLVLERKLQALSAAVEKKEVQFNEV 388
+N +L ++ S+ + K E + ++
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQI 613
Score = 44.3 bits (103), Expect = 2e-04
Identities = 104/454 (22%), Positives = 194/454 (42%), Gaps = 86/454 (18%)
Query: 44 REREERNYFQLERDKIHTFWEITRRQ-LEEKKAELRNKDREMEEAEERHQVEIKVYKQKV 102
+E E+ N ++R I +T R+ L +K + + + ++E+ H++E K+ K
Sbjct: 884 KELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT--HELE-KIGLNK- 939
Query: 103 KHLLYEHQNN------LTEMKAEGTVVM-------KLAQKEHRIQESV-----LRKDMRA 144
+ LL++ Q+ L E K E T+ K+A E R++ES LR++++
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Query: 145 LKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQ----VREIEAKYDKKMKMLRDEL 200
+K K E + + ++ + I+ N +ER+ RE+ D+ +++ R+
Sbjct: 1000 VK---KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1056
Query: 201 DLRR-----KTELHEVEERKNG---QIHTLMQRH---EEAFTDIKNYYNDITLNNLALIN 249
L+ KT+L ++E + N QI L ++ +E T ++ + + N L +
Sbjct: 1057 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1116
Query: 250 ---SLKEQMEDMRKKEDHLEREMAEVSGQN---KRLADPLQKAREEMSEM-QKQLANYE- 301
SL Q + ++ LE E V + K L D L K E++ + ++Q + YE
Sbjct: 1117 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES 1176
Query: 302 -------------------RDKQI----LLCTKARLKVREKELKDLQWE-------HEVL 331
RD + LL K +L+ EK LK Q + HE +
Sbjct: 1177 LISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETV 1236
Query: 332 EQRFTKVQQERDELYRKFTAAIQEVQ----QKTGFKNLVLERKLQ--ALSAAVEKKEVQF 385
+ K+ E D L ++ ++E + K+L+ KL+ L A K + Q+
Sbjct: 1237 AAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1296
Query: 386 NEVLAASNLDPAALTLVSRKLEDVLESKNSTIKD 419
++ S L+S +L+ LE +N + D
Sbjct: 1297 QQLDITSTKLNNQCELLS-QLKGNLEEENRHLLD 1329
Score = 32.7 bits (73), Expect = 0.74
Identities = 52/274 (18%), Positives = 120/274 (43%), Gaps = 32/274 (11%)
Query: 167 HTEEITR-MRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQR 225
H +E+T N F+ Q E+ + ++ L + L K + E +E T+++
Sbjct: 159 HIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSE----TIIEL 214
Query: 226 HEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQK 285
EE D ++ + + + S + + R+ HL E+A+ + +RL L++
Sbjct: 215 SEER--DGLHFLPHASSSAQSPCGSPGMKRTESRQ---HLSVELADAKAKIRRLRQELEE 269
Query: 286 -------AREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKV 338
++E+ +M+ +L +++ LL ++ EL L+ + +++ ++V
Sbjct: 270 KTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEV 329
Query: 339 QQERD-----ELYRKFTAAIQEVQQKTGFKNLVLERKLQALSA------AVEKKEVQFNE 387
+ ++ E Y+ ++E Q +LE +L+ A +EK+ +Q
Sbjct: 330 SRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 388 VLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQ 421
L ++ + +K+E+++E +N T++ Q
Sbjct: 390 KLHDMEME---RDMDRKKIEELME-ENMTLEMAQ 419
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 77.0 bits (188), Expect = 3e-14
Identities = 98/436 (22%), Positives = 195/436 (44%), Gaps = 57/436 (13%)
Query: 24 EDMSKEQVEEHVSRIRE-ELDREREERNYFQLERDKIHTFWEITR-RQLEEKKAELRNKD 81
+++SK+ ++E + E RE ER LE++ H ++ RQ + AE R KD
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 82 REMEEAEERHQVE--------IKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRI 133
E E ++ I+ K+++K L EH E E + +KE+ +
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLEKENEL 643
Query: 134 -QESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKK 192
Q+ + + K+E EQE SE+ +N +LK T + F+ ++E+ +
Sbjct: 644 LQKKITNLKITCEKIEALEQE-NSELERENRKLKKTLD------SFKNLTFQLESLEKEN 696
Query: 193 MKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLK 252
++ + L+LRR E + K Q+ + E +K
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL--------------- 741
Query: 253 EQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKA 312
E ++ KK + LE + +N+RL L+ + +++ +++ +L + E + Q L
Sbjct: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
Query: 313 RLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQ--EVQQKTGFKNLV---- 366
LK+ K L+ L+ E++ LEQ +++++++ +L ++ Q E++ T +N V
Sbjct: 802 ELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861
Query: 367 LERKLQALSAAV----------EKKEVQFNEVLAASNLDPAALT-----LVSRKLEDVLE 411
LE++ + LS + ++ E + E++ + +D L LVS KL+ +
Sbjct: 862 LEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK--TQ 919
Query: 412 SKNSTIKDLQYELAQV 427
N+ ++ L +EL ++
Sbjct: 920 QMNNDLEKLTHELEKI 935
Score = 66.2 bits (160), Expect = 6e-11
Identities = 91/433 (21%), Positives = 185/433 (42%), Gaps = 62/433 (14%)
Query: 29 EQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAE 88
EQ+E+ + +E + +++ + E ++ EI LEE ++ N ++E +
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVE 148
+ EI +YK+ L E++ E ++K A ++ K + L+ +
Sbjct: 871 K----EIGIYKESCVRL--------KELEKENKELVKRA--------TIDIKTLVTLRED 910
Query: 149 LKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEL 208
L ++L ++ + +L K T E+ ++ + ER + + E D + K+L +L+ K L
Sbjct: 911 LVSEKLKTQQMNNDLE-KLTHELEKIGLNKERLLHD-EQSTDDRYKLLESKLESTLKKSL 968
Query: 209 HEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLERE 268
E++E K I L R EE+ YN L + E ++ R+ E+ + +
Sbjct: 969 -EIKEEK---IAALEARLEESTN-----YNQQLRQELKTVKKNYEALKQ-RQDEERMVQS 1018
Query: 269 MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK------ 322
+SG++ + Q+ E+ +++ +L ER+ L K LK + K+L+
Sbjct: 1019 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1078
Query: 323 ------------DLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERK 370
LQ ++ L+ + K+Q E L + T+ + + Q L+ +
Sbjct: 1079 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL-----LIQQSS 1133
Query: 371 LQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLE---SKNSTI----KDLQYE 423
L+ + +V K+ + + D L L+ + E SK+ T+ K+L+ E
Sbjct: 1134 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193
Query: 424 LAQVCKAHNDLLR 436
+ +N LL+
Sbjct: 1194 HRDLEDRYNQLLK 1206
Score = 60.5 bits (145), Expect = 3e-09
Identities = 77/386 (19%), Positives = 177/386 (45%), Gaps = 54/386 (13%)
Query: 44 REREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVK 103
+ E R + +E R++LEEK +L + +E+E+ E +E+K +Q+
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQME----IELKRLQQENM 296
Query: 104 HLLYE------HQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASE 157
+LL + +++ L ++ + V KL + R +E + D+ K ++E + ++
Sbjct: 297 NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL--HDIEFYKARVEELKEDNQ 354
Query: 158 VVVK-NLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKN 216
V+++ L+ E TR R+D ++ + + K+ + E D+ RK +EE
Sbjct: 355 VLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT 414
Query: 217 -------------------GQIHTLMQRHEEAFTDIKNYYNDITLNNLALI----NSLKE 253
QI + E + + N++T + L + SL +
Sbjct: 415 LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTK 474
Query: 254 QMEDMRKKEDHLE---REMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCT 310
+E++R D +E ++ ++ +N+RL+ ++ E+ + ++ L N + + L+
Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
Query: 311 KARLKV--------REKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGF 362
KA+L+ E+++K L+ E+E L Q + ++Q R ++ + A ++++++
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISAE--ARVKDIEK---- 587
Query: 363 KNLVLERKLQALSAAVEKKEVQFNEV 388
+N +L ++ S+ + K E + ++
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQI 613
Score = 44.7 bits (104), Expect = 2e-04
Identities = 104/453 (22%), Positives = 194/453 (42%), Gaps = 85/453 (18%)
Query: 44 REREERNYFQLERDKIHTFWEITRRQ-LEEKKAELRNKDREMEEAEERHQVEIKVYKQKV 102
+E E+ N ++R I +T R+ L +K + + + ++E+ H++E K+ K
Sbjct: 884 KELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT--HELE-KIGLNK- 939
Query: 103 KHLLYEHQNN-----LTEMKAEGTVVM-------KLAQKEHRIQESV-----LRKDMRAL 145
+ LL++ Q+ L E K E T+ K+A E R++ES LR++++ +
Sbjct: 940 ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 999
Query: 146 KVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQ----VREIEAKYDKKMKMLRDELD 201
K K E + + ++ + I+ N +ER+ RE+ D+ +++ R+
Sbjct: 1000 K---KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 202 LRR-----KTELHEVEERKNG---QIHTLMQRH---EEAFTDIKNYYNDITLNNLALIN- 249
L+ KT+L ++E + N QI L ++ +E T ++ + + N L +
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 250 --SLKEQMEDMRKKEDHLEREMAEVSGQN---KRLADPLQKAREEMSEM-QKQLANYE-- 301
SL Q + ++ LE E V + K L D L K E++ + ++Q + YE
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176
Query: 302 ------------------RDKQI----LLCTKARLKVREKELKDLQWE-------HEVLE 332
RD + LL K +L+ EK LK Q + HE +
Sbjct: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1236
Query: 333 QRFTKVQQERDELYRKFTAAIQEVQ----QKTGFKNLVLERKLQ--ALSAAVEKKEVQFN 386
+ K+ E D L ++ ++E + K+L+ KL+ L A K + Q+
Sbjct: 1237 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQ 1296
Query: 387 EVLAASNLDPAALTLVSRKLEDVLESKNSTIKD 419
++ S L+S +L+ LE +N + D
Sbjct: 1297 QLDITSTKLNNQCELLS-QLKGNLEEENRHLLD 1328
Score = 32.7 bits (73), Expect = 0.74
Identities = 52/274 (18%), Positives = 120/274 (43%), Gaps = 32/274 (11%)
Query: 167 HTEEITR-MRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQR 225
H +E+T N F+ Q E+ + ++ L + L K + E +E T+++
Sbjct: 159 HIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSE----TIIEL 214
Query: 226 HEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQK 285
EE D ++ + + + S + + R+ HL E+A+ + +RL L++
Sbjct: 215 SEER--DGLHFLPHASSSAQSPCGSPGMKRTESRQ---HLSVELADAKAKIRRLRQELEE 269
Query: 286 -------AREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKV 338
++E+ +M+ +L +++ LL ++ EL L+ + +++ ++V
Sbjct: 270 KTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEV 329
Query: 339 QQERD-----ELYRKFTAAIQEVQQKTGFKNLVLERKLQALSA------AVEKKEVQFNE 387
+ ++ E Y+ ++E Q +LE +L+ A +EK+ +Q
Sbjct: 330 SRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 388 VLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQ 421
L ++ + +K+E+++E +N T++ Q
Sbjct: 390 KLHDMEME---RDMDRKKIEELME-ENMTLEMAQ 419
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 77.0 bits (188), Expect = 3e-14
Identities = 106/458 (23%), Positives = 205/458 (44%), Gaps = 73/458 (15%)
Query: 25 DMSKEQVEEHVSRIREELDRE--REERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDR 82
D+ K+ EE ++++++ ++E R+E+ + + + F E + LE+ ++E +
Sbjct: 468 DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQ 527
Query: 83 EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEG----TVVMKLAQKEHRIQESVL 138
E E+ E E+++ K K +L E +N L +++ E T +++L ES L
Sbjct: 528 EKEQQESLALEELELQK---KAILTESENKLRDLQQEAETYRTRILEL--------ESSL 576
Query: 139 RKDMRALKVELKEQELASEVVVKNLRLKHTEEITRM----RNDFERQVREIEAKYDKKMK 194
K ++ K + K+ + E KN KH +EIT M + + E + +A + +K++
Sbjct: 577 EKSLQENKNQSKDLAVHLEAE-KN---KHNKEITVMVEKHKTELESLKHQQDALWTEKLQ 632
Query: 195 MLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL----INS 250
+L+ + +TE+ ++ E+ + TL++ E F N+ TL L + + S
Sbjct: 633 VLKQQY----QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688
Query: 251 LKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQ-KAREEMSEMQKQLANYERDKQILLC 309
L ++ ++ K LE E++ + Q ++ L+ K E+ + Q+Q+ + ++ ++ +
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ 748
Query: 310 TKAR------------LKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKF-------- 349
+ LK R+K LK+ Q E LE + + E + K
Sbjct: 749 RTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQS 808
Query: 350 -----TAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSR 404
T A +E + K L LE + L+ V + E Q +V + LD A + +
Sbjct: 809 ATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV--CTELD--AHKIQVQ 864
Query: 405 KLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKL 442
L LE +NS ++ L QV YE+KL
Sbjct: 865 DLMQQLEKQNSEMEQKVKSLTQV----------YESKL 892
Score = 72.4 bits (176), Expect = 8e-13
Identities = 89/453 (19%), Positives = 197/453 (43%), Gaps = 64/453 (14%)
Query: 25 DMSKEQVEEHVSRI-REELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDRE 83
D K QV++ + ++ ++ + E++ ++ Q+ K+ E ++ E+ K L K+
Sbjct: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKL----EDGNKEQEQTKQILVEKENM 912
Query: 84 MEEAEERHQVEIKVYKQKVK------HLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESV 137
+ + E + EI++ QK+ H+L E T+ K + + K+ QK +QE++
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE--TKFKNQEKKMEKVKQKAKEMQETL 970
Query: 138 LRK------------DMRALKVELKEQELASEVV-------------VKNLRLKHTEEIT 172
+K + AL++ KE++ ++++ V L E+I
Sbjct: 971 KKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE 1030
Query: 173 RMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVE-ERKNGQIHTLMQR------ 225
+ R++ ++ + ++KK+ +EL E+HE++ + K ++ L Q+
Sbjct: 1031 SLTEVHRRELNDVISIWEKKLNQQAEELQ-----EIHEIQLQEKEQEVAELKQKILLFGC 1085
Query: 226 HEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQK 285
+E + + + +N L+EQ++ + L ++ ++ ++L L K
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK 1145
Query: 286 AREEMSEMQKQLANY----ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQE 341
+ +E + +Q+QL E DK+ + ++LK ++E + L+ HE + E
Sbjct: 1146 SLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLE 1205
Query: 342 RDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTL 401
+L + + +KT +LE K L + + N +L+ + T
Sbjct: 1206 FKKLSEELAIQLDICCKKT---EALLEAKTNEL---INISSSKTNAILSRISHCQHRTT- 1258
Query: 402 VSRKLEDVLESKNSTIKDLQYELAQVCKAHNDL 434
K+++ L K T+ +L+ +L Q+ + N L
Sbjct: 1259 ---KVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
Score = 67.4 bits (163), Expect = 3e-11
Identities = 89/405 (21%), Positives = 174/405 (42%), Gaps = 65/405 (16%)
Query: 35 VSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEE-AEERHQV 93
VS + +L + EE+N + +F + T QLEEK+ ++++ ++E E+ +
Sbjct: 1271 VSELEAQLRQLTEEQNTLNI------SFQQATH-QLEEKENQIKSMKADIESLVTEKEAL 1323
Query: 94 EIKVYKQKVKHLLYEHQNNLTEMKAE------GTVVMKLAQKEHRIQESVLRKDMRALKV 147
+ + Q+ E ++ +T++K E +MK KE +++ S L K + L V
Sbjct: 1324 QKEGGNQQ--QAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNV 1381
Query: 148 ELKEQELASE--VVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRK 205
+L+ SE + +LR ++ EE + + + +++ +K+ L D K
Sbjct: 1382 QLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441
Query: 206 TELHEVEERKNGQIHTLMQRHEEAFTDIKN---YYNDITLNNLA--------LINSLKEQ 254
+ + + H + + ++K+ Y D +N L + LK +
Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE 1501
Query: 255 MED----MRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCT 310
MED M KKE +LE E+ + + L D + + E+ + + L NY + K I
Sbjct: 1502 MEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDI---- 1557
Query: 311 KARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERK 370
EH+ L Q+ Q+ +E + ++E ++K L LE +
Sbjct: 1558 ----------------EHKELVQKLQHFQELGEEKDNR----VKEAEEKI----LTLENQ 1593
Query: 371 LQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNS 415
+ ++ A +E K+ + V NL + + LED LES+++
Sbjct: 1594 VYSMKAELETKKKELEHV----NLSVKSKEEELKALEDRLESESA 1634
Score = 65.9 bits (159), Expect = 8e-11
Identities = 92/432 (21%), Positives = 196/432 (45%), Gaps = 37/432 (8%)
Query: 34 HVSRIREELDREREERNYF-QLERDKIHTFWEITRRQL-------EEKKAELRNKDREME 85
H++ + + + R+ +N QLE+DK E T+RQ+ EE+ A+LR++ ++M
Sbjct: 337 HMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE-TKRQMHETLEMKEEEIAQLRSRIKQMT 395
Query: 86 EAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRAL 145
E E++ K+K + +E + + + E Q + K
Sbjct: 396 TQGE----ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451
Query: 146 KVELKEQELA--SEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLR 203
++ L +QEL+ + VV ++ E+I +++ E+++ E + KK++ E +
Sbjct: 452 RISL-QQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQ 510
Query: 204 RKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKK-- 261
K L + + Q+ A +++ I + + L+++ E R +
Sbjct: 511 MKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRIL 570
Query: 262 --EDHLEREMAEVSGQNKRLADPLQKAREEMS-EMQKQLANYERDKQILLCTKARLKVRE 318
E LE+ + E Q+K LA L+ + + + E+ + ++ + + L + L +
Sbjct: 571 ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEK 630
Query: 319 KELKDLQWEHEVLEQRFTKVQQERDELYRK----FTAAIQEVQQKTGFKNLVLERKLQAL 374
++ Q++ E +E+ K +QE++ L + F A I+E+ +KT K V + +L++L
Sbjct: 631 LQVLKQQYQTE-MEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL 689
Query: 375 SAAVEKKEVQFNEVLAASNLDPAALTLV---SRKLEDVLESKNSTIKD-LQYELAQVCKA 430
S+ + +EVL A + L+++ + K++ LE+K K+ Q ++ + K
Sbjct: 690 SS-------ELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKE 742
Query: 431 HNDLLRTYEAKL 442
H ++ E L
Sbjct: 743 HEVSIQRTEKAL 754
Score = 55.8 bits (133), Expect = 8e-08
Identities = 96/424 (22%), Positives = 179/424 (42%), Gaps = 43/424 (10%)
Query: 27 SKEQVE--EHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREM 84
SKE E E ++ ++EELD++ + + + E + + E LE + + E+
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530
Query: 85 EEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRA 144
E+ + +EI+ + +K+ Y Q ++ +L QK QE KD R
Sbjct: 1531 EDHITQKTIEIESLNEVLKN--YNQQKDIEH--------KELVQKLQHFQELGEEKDNRV 1580
Query: 145 LKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRR 204
+ E K L ++V E+ + + E +++K ++++K L D L+
Sbjct: 1581 KEAEEKILTLENQV------YSMKAELETKKKELEHVNLSVKSK-EEELKALEDRLESES 1633
Query: 205 KTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDH 264
+L E++ + +I + ++ + + Y T ++L+ +N+ ++ R++E H
Sbjct: 1634 AAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQE----REREVH 1689
Query: 265 -LEREMAEV-SGQNKRLADPLQ----KAREEMSEMQKQLANYERDKQILLCTKARLKVRE 318
LE ++ V S Q++ L P A E E Q + ++ + + L +E
Sbjct: 1690 ILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE 1749
Query: 319 KELKDL-QWEHEVLEQRFTKVQQERDELYR--KFTAAIQEVQQKTGFKNLVLERKLQALS 375
K L+ + Q + E + F Q ++ L + A E Q G LE K + S
Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 376 AAVE---KKEVQFNEVLAASNL----DPAALTLVSRKLE-DVLESKNSTIKDLQYELAQV 427
V +KE N + A NL D TL ++L +LE K IK+L L +
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQK---IKELDSCLVRQ 1866
Query: 428 CKAH 431
+ H
Sbjct: 1867 KEVH 1870
Score = 52.4 bits (124), Expect = 9e-07
Identities = 103/510 (20%), Positives = 207/510 (40%), Gaps = 103/510 (20%)
Query: 28 KEQVEEHVSRIREELDRERE-----ERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDR 82
K+Q + + ++RE+ ++E+E + FQ ++++ E T +L+ K+ EL +
Sbjct: 635 KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN---EKTLEKLDVKQTELESLSS 691
Query: 83 EMEEA-EERHQVE--IKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLR 139
E+ E + RH++E + V K + + E + + E K + KEH + ++
Sbjct: 692 ELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVS---IQ 748
Query: 140 KDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAK----------- 188
+ +ALK ++ + EL + K+L+ +H + + D +R E++
Sbjct: 749 RTEKALKDQINQLELLLKERDKHLK-EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 807
Query: 189 ---------YDKKMKMLRDEL-DLRRKT-----ELHEVEERKNG----------QIHTLM 223
Y++++ L+ +L DL + ++ EVE +K Q+ LM
Sbjct: 808 SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867
Query: 224 QRHEEAFTDIKNYYNDITL---NNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLA 280
Q+ E+ ++++ +T + L N +EQ + + +++++ +M E GQ K +
Sbjct: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMRE--GQKKEIE 925
Query: 281 ----------------------------DPLQKAREEMSEMQKQLANYERDKQILLCTKA 312
++K +++ EMQ+ L D++ L +
Sbjct: 926 ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Query: 313 RLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVL----- 367
E K+ Q+ ++LE D + R T ++++ T L
Sbjct: 986 ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVIS 1045
Query: 368 --ERKL-QALSAAVEKKEVQFNE-VLAASNLDPAALTLVSRK---------LEDVLESKN 414
E+KL Q E E+Q E + L L K L++ ++
Sbjct: 1046 IWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD 1105
Query: 415 STIKDLQYELAQVCKAHNDLLRTYEAKLLA 444
+T+ +LQ +L Q AH + L E KL A
Sbjct: 1106 TTLNELQEQLKQK-SAHVNSLAQDETKLKA 1134
Score = 50.4 bits (119), Expect = 3e-06
Identities = 82/425 (19%), Positives = 181/425 (42%), Gaps = 72/425 (16%)
Query: 65 ITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHL------LYEHQNNLTEMKA 118
+ +R L EK+ L+ +E EE H Y++++ L +E Q+ + ++
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799
Query: 119 E--------GTVVMKLAQKE---HRIQ-ESVLRKDMRALKVELKEQELASEVVVKNLRLK 166
E +V + +KE + IQ + L ++ L+E+EL +++ + ++ +
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIK-E 1858
Query: 167 HTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRK-TELHEVEERKNGQIHTLMQR 225
+ R + ++ E+ +KY+K + ++D R K TEL E + + H + +
Sbjct: 1859 LDSCLVRQKEVHRVEMEELTSKYEKLQAL--QQMDGRNKPTELLEENTEEKSKSHLVQPK 1916
Query: 226 HEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQK 285
L+++++ Q D+ K ERE ++ + RL L+
Sbjct: 1917 ---------------------LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRM 1955
Query: 286 AREE-MSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDE 344
R+E E++ Y+++++ K + + + ELK +++ + T++ Q+ E
Sbjct: 1956 LRKEHQQELEILKKEYDQERE----EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE 2011
Query: 345 LYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSR 404
L I + Q+ +E +L +E + + N++L L ++
Sbjct: 2012 LEMTIKETINKAQE--------VEAEL------LESHQEETNQLLKKIAEKDDDLKRTAK 2057
Query: 405 KLEDVLESK----NSTIKDLQYELAQVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETA 460
+ E++L+++ + ++DLQ +L ++ K + L E DNV L+T
Sbjct: 2058 RYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEE------NPGNDNVTIMELQTQ 2111
Query: 461 VIGQT 465
+ +T
Sbjct: 2112 LAQKT 2116
Score = 42.4 bits (98), Expect = 0.001
Identities = 57/243 (23%), Positives = 98/243 (40%), Gaps = 58/243 (23%)
Query: 40 EELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRN-------------KDREMEE 86
E L+ EE++ L + K+ + E LE K A KD M
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
Query: 87 AEERHQVEI--KVYKQKVKHLLYEHQNNLTEMKAEGTVVM-------KLAQKEHRIQESV 137
E + ++EI K Y Q+ + + + Q +L E+K T+ +LAQKE ++ ++
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDL-ELKHNSTLKQLMREFNTQLAQKEQELEMTI 2016
Query: 138 LRKDMRALKVELK--------EQELASEVVVKNLRLKHT------------EEITRMRND 177
+A +VE + +L ++ K+ LK T EE+T D
Sbjct: 2017 KETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRD 2076
Query: 178 FERQVREIEAKYDKKMK-----------MLRDELDLRRKTELHE----VEERKNGQIHTL 222
+ Q+ E++ KY +K++ ++ + L +KT L E+ QIH L
Sbjct: 2077 LQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNL 2136
Query: 223 MQR 225
R
Sbjct: 2137 EDR 2139
Score = 39.7 bits (91), Expect = 0.006
Identities = 70/362 (19%), Positives = 151/362 (41%), Gaps = 64/362 (17%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAEL-RNKDR 82
+ ++KEQ+ + + R+ L R + + ++ T +++ +R+ ++ + L +++D+
Sbjct: 132 DSLNKEQLIQRLRRMERSLSSYRGKYS-------ELVTAYQMLQREKKKLQGILSQSQDK 184
Query: 83 EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDM 142
+ E + E+++ +Q KHL E +L E K+ I SVL+ +
Sbjct: 185 SLRRIAELRE-ELQMDQQAKKHLQEEFDASLEE-------------KDQYI--SVLQTQV 228
Query: 143 RALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDL 202
LK L+ + +V+ +L+ E+ + E + + D +
Sbjct: 229 SLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPV----------VEDGTSV 278
Query: 203 RRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKE 262
+ L + +R+ L++R +E K +T AL L E+++++ K +
Sbjct: 279 KTLETLQQRVKRQEN----LLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK 334
Query: 263 DHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK 322
D MAE + +L L+ A+ + ++ E+DK +++ R
Sbjct: 335 D---LHMAEKT----KLITQLRDAKNLIEQL-------EQDKGMVIAETKRQM------- 373
Query: 323 DLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKE 382
HE LE + ++ Q R + + T + +QK + E +ALS A + +E
Sbjct: 374 -----HETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE 428
Query: 383 VQ 384
+
Sbjct: 429 AR 430
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 77.0 bits (188), Expect = 3e-14
Identities = 91/400 (22%), Positives = 194/400 (48%), Gaps = 55/400 (13%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITR-------RQLEEKKAELRNK 80
KE +E+ + +EL++ + E+ ++H +E R++++ K ++ +
Sbjct: 329 KETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSH 388
Query: 81 DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV-------MKLAQKEHRI 133
+++ A+ + + E+ +K+ K L E LT+ K E + +K Q+ I
Sbjct: 389 VIKVKWAQNKLKAEMDSHKE-TKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEI 447
Query: 134 QESVLRKDMRALKVELKE--QELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDK 191
+ + L +R K EL++ QE + ++ + + ++K E++ R + ++R +
Sbjct: 448 KSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRT---- 503
Query: 192 KMKMLRDELDLRRKTELHEVEE---RKNGQIHTLMQRHEEA----------FTDIKNYYN 238
K+K L DE LR + EL + +E R+ +I L+ + + A +I+N
Sbjct: 504 KVKCLEDE-RLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKE 562
Query: 239 DITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRL---ADPLQKAREEMSEMQK 295
++ N +LIN L++ +E RK+E L ++ +N +L ++ LQ +++S +
Sbjct: 563 EVESLN-SLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSES 621
Query: 296 QL-ANYERDKQILLCTKARL----KVREKELKDLQWE----HEVLEQRFTKVQQERDELY 346
QL + E+ KQ + ++RL ++R++E++ LQ E ++ T+V++ +DEL
Sbjct: 622 QLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELV 681
Query: 347 ---RKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEV 383
RK ++I+++ ++ RKL + + KEV
Sbjct: 682 TQRRKHASSIKDLTKQL----QQARRKLDQVESGSYDKEV 717
Score = 60.1 bits (144), Expect = 4e-09
Identities = 74/341 (21%), Positives = 158/341 (46%), Gaps = 36/341 (10%)
Query: 117 KAEGTVVM--KLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRM 174
K E +V+ K Q ++ QE +++K +K K QEL ++ + L+ E +
Sbjct: 186 KGEHALVLFEKCVQDKYLQQEHIIKK---LIKENKKHQELFVDICSEKDNLR---EELKK 239
Query: 175 RNDFERQ----VREIEAKYD---KKMKMLRDELDLRRKTELHEVEERKNGQIHTLM-QRH 226
R + E+Q ++++E++ + K++K RD+L + T + V+ Q+H M QR
Sbjct: 240 RTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQ-----QLHKEMAQRM 294
Query: 227 EEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKA 286
E+A + + + + KE + D+RK+++ LE+++ + + + ++ + +++
Sbjct: 295 EQANKKCEEARQEKEAMVMKYVRGEKESL-DLRKEKETLEKKLRDANKELEKNTNKIKQL 353
Query: 287 REEMSEMQKQLANYERDKQILLCTKARLK--VREKELKDLQWEHEVLEQRFTKVQQERDE 344
+E + + E + L+ +LK + +K ++W L+ ++ +D+
Sbjct: 354 SQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIK-VKWAQNKLKAEMDSHKETKDK 412
Query: 345 LYR---KFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTL 401
L K T A +E Q + + + E +E++ NE+ A + L
Sbjct: 413 LKETTTKLTQAKEEADQ-------IRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEK 465
Query: 402 VSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKL 442
++ D LE ++ IK+L+ +L + K D LRT K+
Sbjct: 466 QMQEKSDQLEMHHAKIKELE-DLKRTFKEGMDELRTLRTKV 505
Score = 42.0 bits (97), Expect = 0.001
Identities = 69/379 (18%), Positives = 156/379 (41%), Gaps = 53/379 (13%)
Query: 64 EITRRQLEEKKAELRNKDREMEEAEERHQVEI-KVYKQKVKHLLYEHQNNLTEMKAEGTV 122
++T+ +E + + E +E + + K + K+K + ++ L E+++E
Sbjct: 114 KVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSAS-EDLLEEIESE--- 169
Query: 123 VMKLAQKEHRIQESVLRKDMRALKVE--LKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
++ EHR+ + + + + E ++++ L E ++K L ++ +
Sbjct: 170 LLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKH---------- 219
Query: 181 QVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDI 240
+E+ + LR+EL R +TE + K L R EE ++K + +
Sbjct: 220 --QELFVDICSEKDNLREELKKRTETEKQHMNTIKQ-----LESRIEELNKEVKASRDQL 272
Query: 241 TLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANY 300
++ N++++ L +EMA+ R+ +K E E + + Y
Sbjct: 273 IAQDVTAKNAVQQ-----------LHKEMAQ------RMEQANKKCEEARQEKEAMVMKY 315
Query: 301 ERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKT 360
R ++ L + + EK+L+D E E + ++ QE+ L++ + E +
Sbjct: 316 VRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTR-- 373
Query: 361 GFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL 420
L R++ L + + +V A N A + ++ +D L+ + +
Sbjct: 374 ------LIREIDKLKEDINSHVI---KVKWAQNKLKAEMD-SHKETKDKLKETTTKLTQA 423
Query: 421 QYELAQVCKAHNDLLRTYE 439
+ E Q+ K D+++TY+
Sbjct: 424 KEEADQIRKNCQDMIKTYQ 442
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 76.6 bits (187), Expect = 4e-14
Identities = 92/451 (20%), Positives = 211/451 (46%), Gaps = 58/451 (12%)
Query: 32 EEHVSRIREELDREREERNYFQLE--------RDKIHTFWEITR-RQLEEKKAELRNKDR 82
+E + R++E L ER++ E ++K + F ++T + +EK E+ + +
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL-K 1650
Query: 83 EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKA-----------EGTVVMKLAQKEH 131
E E ++ + I+ ++ +L+E NL EM++ E T+ ++ Q +
Sbjct: 1651 EQFETQKLNLENIETENIRLTQILHE---NLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
Query: 132 RIQESVLR-----KDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIE 186
++E++ R ++++ + + LKE + + + + + + T EI+ M+ D E ++
Sbjct: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKL-RGIVSEKTNEISNMQKDLEHSNDALK 1766
Query: 187 A---KYDKKMKMLRDELDLRRKT--ELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDIT 241
A K +++++ L +++T +L + K ++ + + E + ++ ++
Sbjct: 1767 AQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK 1826
Query: 242 LNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQ----------NKRLADPLQKAREEMS 291
N LI +LK+ + + +KK +E+ ++ Q N LA L + EEM
Sbjct: 1827 ANEHQLI-TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMK 1885
Query: 292 EMQKQLANYERDKQILLCTKARLK--VREKELKDLQWEHEVLEQRFTKVQQER--DELYR 347
+ K+ N R ++ L + +LK ++E + +DL+ + E+ R + + D+L
Sbjct: 1886 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945
Query: 348 KF---TAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSR 404
K T I ++Q+ L++K+Q L +KKE+Q V N+ + +
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQEL----QKKELQLLRVKEDVNMSHKKINEM-E 2000
Query: 405 KLEDVLESKNSTIKDLQYELAQVCKAHNDLL 435
+L+ E++N +++ ++ + Q+ K ++ L
Sbjct: 2001 QLKKQFEAQNLSMQSVRMDNFQLTKKLHESL 2031
Score = 67.4 bits (163), Expect = 3e-11
Identities = 80/424 (18%), Positives = 185/424 (43%), Gaps = 45/424 (10%)
Query: 23 PEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDR 82
P+D + ++E + + + L +E E+D + E+ + + ++ K ++
Sbjct: 1411 PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVA 1470
Query: 83 EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQK-----EHRIQE-- 135
+ E EE +V K++ + + E + NL+E + E + + K + +++IQE
Sbjct: 1471 KHLETEEELKVAHCCLKEQ-EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIY 1529
Query: 136 -----------SVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVRE 184
S +++ + LK + KE A + ++++ K E R++ E +
Sbjct: 1530 EKEEQFNIKQISEVQEKVNELK-QFKEHRKAKDSALQSIESKMLELTNRLQESQEE--IQ 1586
Query: 185 IEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNN 244
I K ++MK +++ L + R +++E + + + E+ + +K + T
Sbjct: 1587 IMIKEKEEMKRVQEALQIER----DQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEK 1642
Query: 245 LALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDK 304
+ I LKEQ E + +++E E N RL L + EEM + K+ + +
Sbjct: 1643 MCEIEHLKEQFETQKLNLENIETE-------NIRLTQILHENLEEMRSVTKERDDLRSVE 1695
Query: 305 QILLCTKARLK--VREKELKDLQWEHE--VLEQRFTKVQQERDELYRKFTAAIQEVQQKT 360
+ L + +LK +RE +DL+ + E ++ + Q+ D+L + E+
Sbjct: 1696 ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISN-- 1753
Query: 361 GFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDL 420
+++ L+ + A++ ++++ E L +++ KL ++ K + ++
Sbjct: 1754 ------MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM 1807
Query: 421 QYEL 424
Q +L
Sbjct: 1808 QKDL 1811
Score = 66.6 bits (161), Expect = 5e-11
Identities = 82/382 (21%), Positives = 183/382 (47%), Gaps = 50/382 (13%)
Query: 29 EQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAE 88
+ V E R+ +E+ +E F + T ++L+EK E++ + EME+ +
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLK 893
Query: 89 ERHQVEIKVYK--QKVKHLLYEH-QNNLTEMKA--EGTVVMKLAQKEHRIQESVLRKDMR 143
E+ + + ++ K L+ E Q L E+K + +K Q+ +I+ L+ D+
Sbjct: 894 EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953
Query: 144 A---LKVELKEQ---ELAS----EVVVKNLRLKHTEEITR----------MRNDFERQVR 183
+ ++ +EQ L S + + L+ K +EE++R +++F++++
Sbjct: 954 DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMV 1013
Query: 184 EIEAKYDKKMKM-------LRDELDLRRKTELHEVEERKNG---QIHTLMQRHEEAFTDI 233
I+ K D + K ++D + ++ ++ + + KN + +++ E+ TD+
Sbjct: 1014 GIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDL 1073
Query: 234 KNYYNDITLNN---LALI-NSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKARE- 288
K ++T+ N L L+ + LK+Q E + ++++H ++ E+S RLA+ +K +E
Sbjct: 1074 KENI-EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132
Query: 289 --EMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELY 346
++ E Q+QL N + + + ++ + E+++L+ E + E ++ ER EL
Sbjct: 1133 SQQLQEKQQQLLNVQEE-------MSEMQKKINEIENLKNELKNKELTLEHMETERLELA 1185
Query: 347 RKFTAAIQEVQQKTGFKNLVLE 368
+K +EV+ T + ++ E
Sbjct: 1186 QKLNENYEEVKSITKERKVLKE 1207
Score = 64.7 bits (156), Expect = 2e-10
Identities = 80/407 (19%), Positives = 181/407 (44%), Gaps = 50/407 (12%)
Query: 30 QVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEE 89
++E R+ E+ +EE ERD + T E + ++ K +R +++E++
Sbjct: 1325 RIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS 1384
Query: 90 RHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVEL 149
+ + + N+ E E T ++ ++ ++LR ++ L +
Sbjct: 1385 KQEQSL----------------NMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK 1428
Query: 150 KEQELASE---VVVKNLRLKHTEEITRMRND-FERQVREIEAKY---DKKMKMLRDELDL 202
+ QE E V + L+ +E+ + +D + ++EI AK+ ++++K+ L
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488
Query: 203 RRKT--ELHEVEERKNGQIHTLMQRHEEAFTD-----IKNYYNDITLNNLALINSLKEQM 255
+ +T EL K +I T+ Q+ EA D I+ Y N+ I+ ++E++
Sbjct: 1489 QEETINELRVNLSEKETEISTI-QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547
Query: 256 EDMRKKEDHLERE---MAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKA 312
++++ ++H + + + + + L + LQ+++EE+ M K+ +R ++ L +
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607
Query: 313 RLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQ 372
+LK KE+ K QE++ + K TA + ++ ++L + + Q
Sbjct: 1608 QLKENTKEIVAKM-----------KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656
Query: 373 ALSAA-VEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIK 418
L+ +E + ++ ++L + + ++T K D L S T+K
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVT----KERDDLRSVEETLK 1699
Score = 63.2 bits (152), Expect = 5e-10
Identities = 90/454 (19%), Positives = 193/454 (42%), Gaps = 70/454 (15%)
Query: 13 KGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEE 72
K TP V+ ++ ++ ++ + + ++++L+ E +E+D++ E +
Sbjct: 330 KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKV 389
Query: 73 KKAELRNKDREMEEAEERH-QVEIKVYKQ-----------KVKHLLYEHQNNLTEMKAEG 120
+ ++ N R + + Q E+K ++ K+K+ Y Q N+
Sbjct: 390 QNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPT----- 444
Query: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKE--------QELASEVVVKNLRLKHTE-EI 171
+ K H++ ++LR+ ++ E E+ K L ++ E E+
Sbjct: 445 ----NITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESEL 500
Query: 172 TRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVE--ERKNGQIHTLMQRHEEA 229
+R D++ V + E +K +M EL L+ K +L E E ERK + + HE
Sbjct: 501 NSLRADYDNLVLDYEQLRTEKEEM---ELKLKEKNDLDEFEALERKTKKDQEMQLIHE-- 555
Query: 230 FTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQN------------K 277
+++KN + N L N L ++E +R+KED +++ + Q +
Sbjct: 556 ISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLE 615
Query: 278 RLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKEL----KDLQWEHEVLEQ 333
+ DP Q ++ + + + + +R+ L LK + KEL K ++ + ++ +
Sbjct: 616 SIEDPKQ-MKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS 674
Query: 334 RFTKVQQERDELYRKFTAAIQEVQQKTG----------FKNLVLERKL----QALSAAVE 379
+ ++ + +L ++ +A E+ + T NL LE K+ + L+ VE
Sbjct: 675 QLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVE 734
Query: 380 KKEVQFNEVLAASNLD--PAALTLVSRKLEDVLE 411
+ E EV+ S L P+ + + ++++D E
Sbjct: 735 ENEALREEVILLSELKSLPSEVERLRKEIQDKSE 768
Score = 60.5 bits (145), Expect = 3e-09
Identities = 100/492 (20%), Positives = 210/492 (42%), Gaps = 83/492 (16%)
Query: 29 EQVEEHVSRIREELDREREERNYFQLERDKIHTFWEI----------------TRRQLEE 72
+ + V R+R+E+ + EE + E+DK+ F E+ T+ L
Sbjct: 750 KSLPSEVERLRKEIQDKSEELHIITSEKDKL--FSEVVHKESRVQGLLEEIGKTKDDLAT 807
Query: 73 KKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEM-----------KAEGT 121
++ ++ D+E + + H ++QK K +L E++ E+ + G
Sbjct: 808 TQSNYKSTDQEFQNFKTLHM----DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA 863
Query: 122 VVMKLAQKEHRIQESVLRKDMRALKVE-LKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
+ +L+ K +QE R ++E LKEQ + ++ + + T +++ E
Sbjct: 864 LKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE- 922
Query: 181 QVREIEAKYDKKMKMLRDELDLRR---KTELH-------EVEERKNGQIHTLMQRHEEAF 230
+V+ + + D +K L++ L + R K+++H + +E+ + +L Q H+E
Sbjct: 923 EVKTLTQEKD-DLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ-HQETI 980
Query: 231 TDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREM----------------AEVSG 274
+K+ ++ NL + + E ++ ++K ++++ E+
Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
Query: 275 QNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK----DLQWEHEV 330
Q +++ +Q+ E ++ +A E+ K L ++EL+ +L+ + E+
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100
Query: 331 LEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVL-ERKLQALSAAVEKKEVQ--FNE 387
+ Q ++ EL R + EV++K K+ L E++ Q L+ E E+Q NE
Sbjct: 1101 VAQEKNHAIKKEGELSRT-CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
Query: 388 VLAASN-LDPAALTL---------VSRKLEDVLESKNSTIKDLQY--ELAQVCKAHNDLL 435
+ N L LTL +++KL + E S K+ + EL + + D L
Sbjct: 1160 IENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL 1219
Query: 436 RTYEAKLLAFGI 447
R Y ++ A G+
Sbjct: 1220 RGYIREIEATGL 1231
Score = 53.1 bits (126), Expect = 5e-07
Identities = 89/418 (21%), Positives = 186/418 (44%), Gaps = 57/418 (13%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
K ++ E VSR + E ++ FQ + I +KK +L K+ + A
Sbjct: 984 KSKISEEVSRNLHMEENTGETKDEFQQKMVGI------------DKKQDLEAKNTQTLTA 1031
Query: 88 EERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVL-----RKDM 142
+ + EI ++K+ L+ E +N L +M +V+ + Q + ++E++ ++++
Sbjct: 1032 DVKDN-EIIEQQRKIFSLIQE-KNELQQMLE--SVIAEKEQLKTDLKENIEMTIENQEEL 1087
Query: 143 RALKVELKEQELASEVVV--KNLRLKHTEEITRMRN---DFERQVREIEAKYDKKMKML- 196
R L ELK+Q+ E+V KN +K E++R + + E +++E + +K + L
Sbjct: 1088 RLLGDELKKQQ---EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLL 1144
Query: 197 --RDELDLRRKTELHEVE----ERKNGQI---HTLMQRHEEAFTDIKNYYNDITLNNLAL 247
++E+ +K +++E+E E KN ++ H +R E A +NY ++
Sbjct: 1145 NVQEEMSEMQK-KINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERK 1203
Query: 248 INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQIL 307
+ LKE + + DHL + E+ + + L+ A + E Q+ + R
Sbjct: 1204 V--LKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRR----- 1256
Query: 308 LCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVL 367
+ + + +DL+ H L++ + +E++ L + E Q+ L+
Sbjct: 1257 --SVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN--VKEVSETQETMNELELLT 1312
Query: 368 ER---KLQALSAAVEKKEVQFNEVLAASNLDPAALTLVS---RKLEDVLESKNSTIKD 419
E+ K A +E + ++ NE S + +LT + +++ LE K+ +K+
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE 1370
Score = 39.7 bits (91), Expect = 0.006
Identities = 69/342 (20%), Positives = 137/342 (40%), Gaps = 48/342 (14%)
Query: 139 RKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRD 198
RK++ LK +L+E L + + +++ ++ + + + K + +ML
Sbjct: 349 RKEIMDLKKQLEEVSLETRA-----QAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVT 403
Query: 199 ELDLRRKTELHEVEERKN----GQIHTLMQRHEEAFTDIKNYYNDITLNNLAL-INSLKE 253
L + EL +R+ G+I+ + + + D N +IT L IN L+E
Sbjct: 404 SSSLTLQQELKAKRKRRVTWCLGKINKMKNSN---YADQFNIPTNITTKTHKLSINLLRE 460
Query: 254 QMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYER---DKQILLCT 310
E + + D + +S A L SE+ A+Y+ D + L
Sbjct: 461 IDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE 520
Query: 311 KARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERK 370
K ++++ KE DL E E LE++ TK QE ++ + ++ + + N LE +
Sbjct: 521 KEEMELKLKEKNDLD-EFEALERK-TKKDQEMQLIHE--ISNLKNLVKHAEVYNQDLENE 576
Query: 371 LQALSAAVEKKEVQFNEV----------------------------LAASNLDPAALTLV 402
L + + +KE Q ++ + + D + L
Sbjct: 577 LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALD 636
Query: 403 SRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAKLLA 444
+++ L S+N +K+ ELA K + ++ Y+++L A
Sbjct: 637 AKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEA 678
Score = 38.9 bits (89), Expect = 0.010
Identities = 87/476 (18%), Positives = 205/476 (43%), Gaps = 77/476 (16%)
Query: 4 KKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFW 63
K+ ++ KA+ I L M ++ +E V ++RE++ + + + Q + DK
Sbjct: 1909 KESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK----- 1963
Query: 64 EITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV 123
++ +L++K EL+ K+ ++ +E ++ + +K+ E + + +A+ +
Sbjct: 1964 --SKDELQKKIQELQKKELQLLRVKE----DVNMSHKKIN----EMEQLKKQFEAQNLSM 2013
Query: 124 MKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRM-RNDFERQV 182
+ ++ + L + + +++ KE++ L+ +E +M R+ F +
Sbjct: 2014 QSVRMDNFQLTKK-LHESLEEIRIVAKERD----------ELRRIKESLKMERDQFIATL 2062
Query: 183 REIEAKYDKKMKMLRDELDLRRKTELHEVE--ERKNGQIHTLMQRHEEAFTDIKNYYNDI 240
RE+ A+ D++ ++ E L + H E K +I L++R+ E + ++Y +
Sbjct: 2063 REMIAR-DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE----MDDHYECL 2117
Query: 241 TLNNLALINSLKEQME-DMRKKED---------HLER----------EMAEVSGQNKRLA 280
+L L ++ Q E MR K + H+E+ E + + K +
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177
Query: 281 DPLQKAREEMSEMQKQ-----LANYERDKQILL---CTKARLKVREKELKDLQWEH---- 328
+ K +EE E + + E+ K++L+ + V +EL+DL+
Sbjct: 2178 SYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL 2237
Query: 329 --EVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERK--LQALSAAVEKKEVQ 384
E + + F+ + E + +F + ++ T F L + ++ L ++K+ +
Sbjct: 2238 HIEEILKDFS--ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDR 2295
Query: 385 FNEVLAASNLDPAALTLVSRKLEDVLESKNSTI-KDLQYELAQVCKAHNDLLRTYE 439
+V N A+ S + E+ +++TI K+ + +L + + + L + Y+
Sbjct: 2296 ICQVNNFFNNRIIAIMNESTEFEE----RSATISKEWEQDLKSLKEKNEKLFKNYQ 2347
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 75.9 bits (185), Expect = 8e-14
Identities = 71/339 (20%), Positives = 165/339 (48%), Gaps = 32/339 (9%)
Query: 24 EDMSKEQVEEHVSRIREELDREREE--RNYFQLERDKIHTFWEITRRQLEEKKA----EL 77
E+M E+ E+ R +EE+ E+EE R ++ +K E+ + E++K E
Sbjct: 341 EEMMWEKEEK--MRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEK 398
Query: 78 RNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESV 137
R ++ ++ E E+R + E K+++Q+ K + E + + E + + + ++ +I+E
Sbjct: 399 RQEEEKIREQEKRQEQEAKMWRQEEK--IREQEEKIREQEKKMWRQEEKIHEQEKIREEE 456
Query: 138 LRKDMRAL---KVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDK--- 191
R++ + + +++EQE E+ + ++ E+I + RQ ++ + +K
Sbjct: 457 KRQEQEEMWRQEEKIREQE---EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 192 -KMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINS 250
+ KM R E +R + E +E K + +MQ EE + + +
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQ--------EK 565
Query: 251 LKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCT 310
++ Q E +R++E+ + + ++ Q +++ + +K RE+ MQ+Q ++ +
Sbjct: 566 MRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 625
Query: 311 KARLKVREKELK---DLQWEHEV-LEQRFTKVQQERDEL 345
+ +++ +E++++ + WE EV L Q+ K+Q+ ++ L
Sbjct: 626 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 66.6 bits (161), Expect = 5e-11
Identities = 79/381 (20%), Positives = 178/381 (46%), Gaps = 38/381 (9%)
Query: 32 EEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERH 91
++ R EEL +ER+ + +L R+ I T +L+EK A+L+ K + +E +
Sbjct: 188 KKKADRYIEELTKERDALS-LELYRNTI------TDEELKEKNAKLQEKLQLVESEKSEI 240
Query: 92 QVEIKVYKQKVKH--LLYEHQNNLTEMKAEGTVVMKLAQK--------------EHRIQE 135
Q+ +K K+K++ LL Q E G + ++ K + +E
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 300
Query: 136 SVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDF-----ERQVREIEAKYD 190
+ R++ + + E K QE ++ + +++ EE R + + E+ R+ E ++
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 191 KKMKMLR-DELDLRRKTELHEVEERKNGQIHTLMQ---RHEEAFTDIKNYYNDITLNNLA 246
K+ KM R +E+ ++ ++ E+EE+ + Q Q R EE + +
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 420
Query: 247 LINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQI 306
++EQ E +R++E + R+ ++ Q K + ++ +EEM ++++ E +
Sbjct: 421 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 480
Query: 307 LLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLV 366
+ K+R++E K + E ++ +Q K++++ ++++R+ I+E ++K +
Sbjct: 481 KEKMHEQEKIRKQEEKVWRQEEKMHDQE-EKIREQEEKMWRQ-EEKIREQEEKIREQ--- 535
Query: 367 LERKLQALSAAVEKKEVQFNE 387
E K++ ++++E + E
Sbjct: 536 -EEKIREQEEMMQEQEEKMGE 555
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 75.5 bits (184), Expect = 1e-13
Identities = 93/429 (21%), Positives = 194/429 (45%), Gaps = 39/429 (9%)
Query: 27 SKEQVEEHVSRIREELDREREERNYFQLER----DKIHTF------WEITRRQLEEKKAE 76
SK +E V + E L+ E E + ++ DK + E+T ++E++K
Sbjct: 915 SKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHA 974
Query: 77 LRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVV-------MKLAQK 129
NK + + E + I ++ K L HQ L +++ E V KL Q+
Sbjct: 975 TENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQ 1034
Query: 130 EHRI-----QESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVRE 184
+ QE LR D+ K +L+ S+ + +L ++I E ++ +
Sbjct: 1035 TDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE-NDKQQIEEKLKKKEFELSQ 1093
Query: 185 IEAKY-DKKMKMLRDELDLRR-KTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITL 242
++AK D+++ L+ + ++ + + E+EE + HTL + E+ +D+ +I+
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARELEEISE 1152
Query: 243 NNLALINSLKEQMEDMRKKE---DHLEREMAEVSGQNKRLADPLQKAR-EEMSEMQKQLA 298
+ Q+E +K+E + R++ E + Q++ A L+K + + ++E+ +Q+
Sbjct: 1153 RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID 1212
Query: 299 NYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQ 358
N +R KQ L K+ LK+ E+ D+ E L + + +++ + +F+ + +Q
Sbjct: 1213 NLQRVKQKLEKEKSELKM---EIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Query: 359 KT------GFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLES 412
+T + L+ + LS VE+KE +++ + L + R++E+ ++
Sbjct: 1270 QTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKA 1329
Query: 413 KNSTIKDLQ 421
KN+ LQ
Sbjct: 1330 KNAMAHALQ 1338
Score = 61.6 bits (148), Expect = 1e-09
Identities = 114/473 (24%), Positives = 198/473 (41%), Gaps = 89/473 (18%)
Query: 25 DMSKEQVEEHVSRIREELDREREERNYFQLE-RDKIHTFWEITRRQLEEKKAELRNKDRE 83
D+ +EQ EE + EL R + N + R K T +LEE K +L + +E
Sbjct: 1345 DLLREQYEEE-QEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1403
Query: 84 MEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEH-----------R 132
EE E + ++ + L E ++ + +++ T L +K+ +
Sbjct: 1404 AEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQK 1463
Query: 133 IQES-----VLRKDMRALKVELKEQELASEVVV----------KNLR------------- 164
+ ES +K+ R+L EL + A E VV KNL+
Sbjct: 1464 LDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAET 1523
Query: 165 ---LKHTEEITRM----RNDFERQVREIEAKYD-KKMKMLRDELDLRR-KTELHEVEERK 215
L+ E+ ++ ++D + + E+E + ++ K+LR +L+L + K+EL K
Sbjct: 1524 GKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEK 1583
Query: 216 NGQIHTLMQRHEEAFTDIKNYYN-DITLNNLALINSLKEQME----DMRKKEDHLEREMA 270
+ +I L + + A +++ + +I N AL LK++ME +M + H R+MA
Sbjct: 1584 DEEIEQLKRNSQRAAEALQSVLDAEIRSRNDAL--RLKKKMEGDLNEMEIQLGHSNRQMA 1641
Query: 271 E-------VSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKV------- 316
E V GQ K L A ++++QLA ER +LL +KV
Sbjct: 1642 ETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTER 1701
Query: 317 ----REKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQ 372
E+EL D ++L + T + + +K A I + Q + +E +Q
Sbjct: 1702 TRRLSEQELLDASDRVQLLHSQNTSLINTK----KKLEADIAQCQAE-------VENSIQ 1750
Query: 373 ALSAAVEK-KEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYEL 424
A EK K+ + + A L T S LE + ++ T+KDLQ+ L
Sbjct: 1751 ESRNAEEKAKKAITDAAMMAEELKKEQDT--SAHLERMKKNLEQTVKDLQHRL 1801
Score = 58.9 bits (141), Expect = 1e-08
Identities = 87/417 (20%), Positives = 173/417 (41%), Gaps = 61/417 (14%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLE---EKKAELRNK 80
E++ +E EH R + E R R ++ +++ T Q+E +++AE +
Sbjct: 1120 EELEEEIEAEHTLRAKIEKQRSDLARELEEIS-ERLEEASGATSAQIEMNKKREAEFQKM 1178
Query: 81 DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRK 140
R++EEA +H+ ++K +++ E+ + + ++ QK L K
Sbjct: 1179 RRDLEEATLQHEATAATLRKK-------QADSVAELGEQIDNLQRVKQK--------LEK 1223
Query: 141 DMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDEL 200
+ LK+E+ ++AS + + K I R E Q EI+AK +++ +++ D L
Sbjct: 1224 EKSELKMEI--DDMASNIEALS---KSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHD-L 1277
Query: 201 DLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRK 260
+++ K L + +NG++ ++ E + + +T + LK QME+ K
Sbjct: 1278 NMQ-KARL----QTQNGELSHRVEEKESLISQLTKSKQALTQQ----LEELKRQMEEETK 1328
Query: 261 KEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKE 320
++ + + L + ++ +E +E+Q+ L +KA +V +
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRAL------------SKANSEVAQWR 1376
Query: 321 LKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKN---LVLERKLQALSAA 377
K +E + +++ +E +E +K +QE ++ T N LE+ Q L
Sbjct: 1377 TK---YETDAIQR-----TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
Query: 378 VEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDL 434
VE L S+ A L R + VL + + Q EL K L
Sbjct: 1429 VE----DLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL 1481
Score = 54.7 bits (130), Expect = 2e-07
Identities = 101/505 (20%), Positives = 219/505 (43%), Gaps = 111/505 (21%)
Query: 25 DMSKEQVEEHVSRIREELDR--------EREERNYFQLERDKIHTFWEITRRQLEEKKAE 76
+ +K++++ V + +L+R ++++RN+ DK+ W +++L+E +AE
Sbjct: 1419 EKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNF-----DKVLAEW---KQKLDESQAE 1470
Query: 77 LRNKDRE----------MEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKL 126
L +E M A E +++ +++ K+L E ++LTE AE ++
Sbjct: 1471 LEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNL-QEEISDLTEQIAETGKNLQE 1529
Query: 127 AQKEHRIQE---------------SVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEI 171
A+K ++ E S+ ++ + L+V+L+ ++ SE+ K + + EEI
Sbjct: 1530 AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI--EKDEEI 1587
Query: 172 TRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTE--LHEVE------ERKNGQIHTLM 223
+++ + +R +++ D +++ D L L++K E L+E+E R+ + +
Sbjct: 1588 EQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHL 1647
Query: 224 QRHEEAFTDIKNYYNDITLNN------LALINS----LKEQMEDMRKKEDHLER------ 267
+ + D + + +D +N LA++ L E++E+M+ + ER
Sbjct: 1648 RTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSE 1707
Query: 268 -EMAEVS-------GQNKRLADPLQKAREEMSEMQKQLANY--------ERDKQILLC-- 309
E+ + S QN L + +K ++++ Q ++ N E+ K+ +
Sbjct: 1708 QELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAA 1767
Query: 310 -----------TKARL----KVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQ 354
T A L K E+ +KDLQ + EQ K +++ + ++
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE 1827
Query: 355 ---EVQQKTGFKNL----VLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLE 407
+V+QK G + L ERK++ ++ E+ + + A + R+ E
Sbjct: 1828 NELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAE 1887
Query: 408 DVLESKN---STIKDLQYELAQVCK 429
+ E N S + +Q+EL + +
Sbjct: 1888 EAEEQANTQLSRCRRVQHELEEAAE 1912
Score = 53.9 bits (128), Expect = 3e-07
Identities = 57/262 (21%), Positives = 115/262 (43%), Gaps = 35/262 (13%)
Query: 169 EEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEE 228
+E+ M+ DFER E+ A+ + + K L +++ + ++E+ + Q+ +Q E
Sbjct: 851 KEMATMKEDFERTKEEL-ARSEARRKELEEKM-------VSLLQEKNDLQLQ--VQSETE 900
Query: 229 AFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKARE 288
D + + + + L +KE E + ++E+ +E+ + + L D +
Sbjct: 901 NLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEM----NSELVAKKRNLEDKCSSLKR 956
Query: 289 EMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRK 348
++ +++ L E++K E ++K+L E LE+ +K+ +E+ L
Sbjct: 957 DIDDLELTLTKVEKEKH----------ATENKVKNLSEEMTALEENISKLTKEKKSL--- 1003
Query: 349 FTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDP---AALTLVSRK 405
QE Q+T V E K+ L K E Q +++ + + A L RK
Sbjct: 1004 -----QEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRK 1058
Query: 406 LEDVLESKNSTIKDLQYELAQV 427
LE L+ +I DL+ + Q+
Sbjct: 1059 LEGDLKMSQESIMDLENDKQQI 1080
Score = 33.5 bits (75), Expect = 0.44
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 9/121 (7%)
Query: 318 EKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQE-----VQQKTGFKNLV-LERKL 371
EKE+ ++ + E ++ + + R EL K + +QE +Q ++ +NL+ E +
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909
Query: 372 QAL---SAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVC 428
+ L +E K + E L + L R LED S I DL+ L +V
Sbjct: 910 EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVE 969
Query: 429 K 429
K
Sbjct: 970 K 970
Score = 32.0 bits (71), Expect = 1.3
Identities = 46/193 (23%), Positives = 87/193 (45%), Gaps = 37/193 (19%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDRE 83
E+ +K+ + + + + EEL +E++ + LER K + LE+ +L+++
Sbjct: 1756 EEKAKKAITD-AAMMAEELKKEQDTSAH--LERMK---------KNLEQTVKDLQHR--- 1800
Query: 84 MEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMR 143
++EAE+ K QK+++ + E +N L + G +K A K R
Sbjct: 1801 LDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYER----------- 1849
Query: 144 ALKVELKEQELASEVVVKN-LRLKH-TEEITRMRNDFERQVREIEAKYDKKMKMLRDELD 201
++KE +E KN LRL+ +++ ++RQ E E + + ++ R
Sbjct: 1850 ----KVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCR---- 1901
Query: 202 LRRKTELHEVEER 214
R + EL E ER
Sbjct: 1902 -RVQHELEEAAER 1913
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 75.1 bits (183), Expect = 1e-13
Identities = 78/352 (22%), Positives = 167/352 (47%), Gaps = 45/352 (12%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
+E++ R+RE+ + RE+ W +R L E++ ELR +++E+ E
Sbjct: 292 EEKMWRQEERLREQEGKMREQE----------EKMWRQEKR-LREQEKELREQEKELREQ 340
Query: 88 EERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKV 147
+E + E ++ +Q+ K ++E + + E + K+ ++E R+ E K MR +
Sbjct: 341 KELREQEEQMQEQEEK--MWEQEEKMREQEE------KMWRQEERLWEQ--EKQMREQEQ 390
Query: 148 ELKEQELASEVVVKNLRLKHT---------EEITRMRNDFERQVREIEAKYDKKMKMLRD 198
++++QE + LR K E++ +MR + + Q +E + + D++ KM +
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR-DQEEKMQEE 449
Query: 199 ELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITL----NNLALINSLKEQ 254
E R+ ++ E EE Q + ++ E + + + L L ++EQ
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 255 MEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARL 314
E + ++E+ + R+ E+ GQ K++ +K RE+ +M +Q +Q + + R+
Sbjct: 510 EEKIWEQEEKI-RDQEEMWGQEKKMWRQ-EKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567
Query: 315 KVREKELKDLQW-------EHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK 359
+ + +E + W E E + +R K+++E +E+ R+ +QE ++K
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREE-EEMMREQEEKMQEQEEK 618
Score = 75.1 bits (183), Expect = 1e-13
Identities = 74/347 (21%), Positives = 165/347 (47%), Gaps = 14/347 (4%)
Query: 24 EDMSKEQVEEHVSRIREEL-DREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDR 82
E+ +EQ EE + R E L ++E++ R Q RD+ WE R L EK+ +R +++
Sbjct: 361 EEKMREQ-EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER-LREKEERMREQEK 418
Query: 83 EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDM 142
E+ E+ + E K+ +Q+ K E + E E M+ ++ R QE ++K
Sbjct: 419 MWEQVEKMRE-EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 477
Query: 143 RALKVELKEQELASEVVVKNLRLKHTEEITRMRN---DFERQVREIEAKYDKKMKMLRDE 199
+ + +++ + + +L E++ + E ++R+ E + ++ KM R E
Sbjct: 478 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 537
Query: 200 LDLRRKTELHEVEERKNGQIHTLMQRHE--EAFTDIKNYYNDITLNNLALINSLKEQMED 257
++ ++ E EE+ Q + + E E T + + ++E+ +
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK 597
Query: 258 MRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARL--K 315
MR++E+ + + ++ Q +++ + +K E+ +MQ+Q ++ + + ++ +
Sbjct: 598 MREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ 657
Query: 316 VREKELKDLQWEHEVLEQRFTKVQQERDELY--RKFTAAIQEVQQKT 360
R E K+ WEHE ++++ K+Q++ ++++ K QE ++KT
Sbjct: 658 QRLPEQKEKLWEHEKMQEQ-EKMQEQEEKIWEQEKMEKKTQEQEKKT 703
Score = 74.3 bits (181), Expect = 2e-13
Identities = 82/354 (23%), Positives = 170/354 (48%), Gaps = 31/354 (8%)
Query: 37 RIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIK 96
R EEL +ER+ + +L R+ I T +L++K AEL+ K E + Q+ +K
Sbjct: 197 RYIEELTKERDALS-LELYRNTI------TNEELKKKNAELQEKLPLAESEKSEIQLNVK 249
Query: 97 VYKQKV---KHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQE 153
K+K+ K LL + Q N + + M ++E R QE +RK +E+
Sbjct: 250 ELKRKLERAKFLLPQVQTNTLQEE------MWRQEEELREQEKKIRKQ--------EEKM 295
Query: 154 LASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEE 213
E ++ K E+ +M E+++RE E + ++ K LR++ +LR + E + +E
Sbjct: 296 WRQEERLREQEGKMREQEEKMWRQ-EKRLREQEKELREQEKELREQKELREQEEQMQEQE 354
Query: 214 RKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVS 273
K + M+ EE + + +++Q E M ++++ L RE E
Sbjct: 355 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL-REKEERM 413
Query: 274 GQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQ 333
+ +++ + ++K REE +MQ+Q RD++ + + R++ REK++++ E E + +
Sbjct: 414 REQEKMWEQVEKMREE-KKMQEQ-EKKTRDQEEKMQEEERIREREKKMRE---EEETMRE 468
Query: 334 RFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNE 387
+ K+Q++ + ++ + Q+ + + L + K+Q + ++E + +
Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
Score = 70.9 bits (172), Expect = 2e-12
Identities = 71/356 (19%), Positives = 177/356 (49%), Gaps = 39/356 (10%)
Query: 28 KEQVEEHVSRIREELDRE-REERNYFQLERDKIHTFWEIT-RRQLEEKKAELRNKDREME 85
+E++ E ++RE+ ++ R+E+ + E++ E+ +++L E++ +++ ++ +M
Sbjct: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
Query: 86 EAEER-HQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRA 144
E EE+ + E K+++Q+ + L+E + + E + K+ +E R+ E R +R
Sbjct: 359 EQEEKMREQEEKMWRQEER--LWEQEKQMREQE------QKMRDQEERMWEQDER--LRE 408
Query: 145 LKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRR 204
+ ++EQE E V K K +E + D E +++E E +++ KM +E +R
Sbjct: 409 KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMRE 468
Query: 205 KTELHEVEER-------KNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQM-- 255
+ E + +E K Q L ++ E+ + K + + +E+M
Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 528
Query: 256 --------EDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQIL 307
E MR++ED + + ++ Q +++ D ++ ++ E +K+ + E +
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR-- 586
Query: 308 LCTKARLKVREKELKD----LQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQK 359
+ R++ REK++++ ++ + E ++++ K+Q++ ++++ + +QE ++K
Sbjct: 587 --EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ-EEKMQEQEEK 639
Score = 62.0 bits (149), Expect = 1e-09
Identities = 62/323 (19%), Positives = 161/323 (49%), Gaps = 20/323 (6%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
+E++ E ++REE + RE+ Q + + + WE ++ ++++ L + ++ E
Sbjct: 449 EERIREREKKMREEEETMREQEEKMQKQEENM---WEQEEKEWQQQR--LPEQKEKLWEQ 503
Query: 88 EERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKV 147
E+ + E K+++Q+ K Q + + + K+ ++E ++ E + MR +
Sbjct: 504 EKMQEQEEKIWEQEEK---IRDQEEMWGQEKKMWRQEKMREQEDQMWEQ--EEKMRDQEQ 558
Query: 148 ELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTE 207
++ +QE E + K ++ +MR E ++RE E K ++ +M+R++ + ++ E
Sbjct: 559 KMWDQEERMEKKTQEQEKKTWDQEEKMRE--EERMREREKKMREEEEMMREQEEKMQEQE 616
Query: 208 --LHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHL 265
+ E EE+ Q + ++ E+ + + + + L EQ E + + E
Sbjct: 617 EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE--EKMWEQQRLPEQKEKLWEHEKMQ 674
Query: 266 EREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQ 325
E+E ++ Q +++ + +K ++ E +K+ + E+ ++ + K+RE+E + ++
Sbjct: 675 EQE--KMQEQEEKIWEQ-EKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE-EMMR 730
Query: 326 WEHEVLEQRFTKVQQERDELYRK 348
+ E ++++ K+Q++ +E++ +
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQ 753
Score = 61.6 bits (148), Expect = 1e-09
Identities = 79/374 (21%), Positives = 170/374 (45%), Gaps = 38/374 (10%)
Query: 28 KEQVEEHVSRI--REELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREME 85
+EQ++E ++ +EE RE+EE+ + Q ER WE +Q+ E++ ++R+++ M
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEER-----LWE-QEKQMREQEQKMRDQEERMW 400
Query: 86 EAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVL----RKD 141
E +ER + K + + + ++E + E K K +E ++QE K
Sbjct: 401 EQDER--LREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
Query: 142 MRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQ-VREIEAKYDKKMKMLRDEL 200
MR + ++EQE + +N+ + +E + R +++ + E E +++ K+ E
Sbjct: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
Query: 201 DLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRK 260
+R + E+ E++ Q M+ E+ + + D + +Q E M K
Sbjct: 519 KIRDQEEMWGQEKKMWRQ--EKMREQEDQMWEQEEKMRDQE-------QKMWDQEERMEK 569
Query: 261 KEDHLER---EMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARL--- 314
K E+ + E + +R+ + +K REE M++Q + ++ + + ++
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 315 --KVREKELK-----DLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVL 367
K++E+E K + WE E ++ +++++L+ QE Q+ K +
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK-IWE 688
Query: 368 ERKLQALSAAVEKK 381
+ K++ + EKK
Sbjct: 689 QEKMEKKTQEQEKK 702
Score = 45.4 bits (106), Expect = 1e-04
Identities = 59/290 (20%), Positives = 125/290 (43%), Gaps = 28/290 (9%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLER-DKIHTFWEITRRQLEEKKAELRNKDR 82
E K Q +E +EE E+EE+ + Q ++ WE + Q +EK E K
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
Query: 83 EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDM 142
E E+ E++ Q + K + K E + E +M+ ++E ++QE + M
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR--EQEEKMQEQ--EEKM 743
Query: 143 RALKVELKEQELASEVVVKNLRLKHTEEITRMRNDF--ERQVREIEAKYDKKMKMLRDEL 200
+ + E+ EQE ++ + ++ + + + +++E E ++++ KM E
Sbjct: 744 QEQEEEMWEQE--EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE 801
Query: 201 DLRRKTE-LHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMR 259
+R + E + EE+ GQ + + E+ + + + Q E M
Sbjct: 802 KMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG---------------QEEKMW 846
Query: 260 KKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLC 309
+E+ +E +M GQ +++ + +K R + +M++Q ++ + C
Sbjct: 847 GQEEKMEEKM---QGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIYC 893
Score = 35.0 bits (79), Expect = 0.15
Identities = 33/163 (20%), Positives = 71/163 (43%)
Query: 220 HTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRL 279
H R+ E T ++ + N LK++ ++++K E E +E+ K L
Sbjct: 192 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL 251
Query: 280 ADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQ 339
L++A+ + ++Q E +Q + K+R++E K + E + EQ +
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 311
Query: 340 QERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKE 382
QE ++ QE + + K L +++L+ ++++E
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQE 354
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 74.7 bits (182), Expect = 2e-13
Identities = 106/484 (21%), Positives = 213/484 (44%), Gaps = 77/484 (15%)
Query: 24 EDMSKEQVEEHVSRIREE-----LDREREERNYFQLERDKIHTFWEITRRQLEEKKAELR 78
E++ ++ EE R + E L+R+ EE+ E ++ E + + ++ EL+
Sbjct: 369 EELQRKLDEEVKKRQKLEPSQVGLERQLEEKTE---ECSRLQELLERRKGEAQQSNKELQ 425
Query: 79 NKDREMEEAEE-RHQVEIKVYK--QKVKHLLYEHQNN---LTEMKAEGTVVMKLAQKEHR 132
N R +++ E+ RH +E +V + K+KH+ L ++ ++ ++ + + R
Sbjct: 426 NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQR 485
Query: 133 IQESVL--RKDMRALKVELKEQELASEVVVKNLRLKH---TEEITRMRNDFERQVREIEA 187
++E + +++ ALK LKE+ + + V+++R ++ TE++ R D + +EA
Sbjct: 486 VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEA 545
Query: 188 KYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL 247
+ K ++R L+R EL E E + G ++ Q+++E K + + +
Sbjct: 546 ERQKMSALVR---GLQR--ELEETSE-ETGHWQSMFQKNKEDLRATKQELLQLRMEKEEM 599
Query: 248 INSLKEQMEDMRK-----------------------------KEDHLEREMAEVSGQN-- 276
L E++E +++ KE ER+ EV+G++
Sbjct: 600 EEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
Query: 277 ----KRL------ADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQW 326
K+L AD ++ E+ ++QK L +D + +KA++ V E E L
Sbjct: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCE--EASKAKM-VAEAEATVLGQ 716
Query: 327 EHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKN--LVLERKLQALSAAVEKKEVQ 384
+E + Q+E DE R+ Q++++ G + +E +L+ +E ++ Q
Sbjct: 717 RRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
Query: 385 FNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKA------HNDLLRTY 438
E L AS + +L R LE LE + L E + +A ++LR
Sbjct: 777 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRG 836
Query: 439 EAKL 442
+A+L
Sbjct: 837 KAEL 840
Score = 72.0 bits (175), Expect = 1e-12
Identities = 85/398 (21%), Positives = 173/398 (43%), Gaps = 36/398 (9%)
Query: 64 EITRRQLEEKKAELRNKDREMEEAEERHQVE---IKVYKQKVKHLLYEHQNNLTEMKAEG 120
E +L +K L + +++EEA Q E + K+ ++ L E Q L + E
Sbjct: 757 EAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ 816
Query: 121 TVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFER 180
+ + ++E + Q VLR+ K EL+EQ+ + V L +E+ ++ D ++
Sbjct: 817 QTLNRALEEEGK-QREVLRRG----KAELEEQKRLLDRTVDRLN----KELEKIGEDSKQ 867
Query: 181 QVREIEAKY-DKKMKMLRDELDLRRKTE--LHEVEERKNG--QIHTLMQRHEEAFTDIKN 235
+++++A+ D K K R+ D +R+ + E E+ G ++ +QR +A +
Sbjct: 868 ALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQA 927
Query: 236 YYNDITLNNLALINSLK-----------------EQMEDMRKKEDHLEREMAEVSGQNKR 278
+ L+ L L+ Q++ + +K LE E+ E +
Sbjct: 928 ERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVEL 987
Query: 279 LADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKV 338
L D + + R+++ +++ +L +Q L C K L+ + K+LK E ++ +
Sbjct: 988 LTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASL 1047
Query: 339 QQ--ERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDP 396
Q +++L ++ A + + N LERK++ LS +E + N+ +L
Sbjct: 1048 SQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRV 1107
Query: 397 AALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDL 434
AL + E+ +E + K Q E+ + + + L
Sbjct: 1108 KALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL 1145
Score = 53.5 bits (127), Expect = 4e-07
Identities = 97/423 (22%), Positives = 173/423 (40%), Gaps = 56/423 (13%)
Query: 35 VSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELR---NKDREMEEAEERH 91
V +++EL R +EE Q ER R+LE++ A LR ++ RE+EE
Sbjct: 627 VEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEE----Q 682
Query: 92 QVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKE 151
++++ Q+++ E +AE TV L Q+ + E+ LR + + +
Sbjct: 683 NLQLQKTLQQLRQDCEEASKAKMVAEAEATV---LGQRRAAV-ETTLR------ETQEEN 732
Query: 152 QELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEV 211
E ++ +LK T + E ++R+ + + + + L + L+ ++ E
Sbjct: 733 DEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLA 792
Query: 212 EERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAE 271
++ L R EEA + + N AL K Q E +R+ + LE +
Sbjct: 793 AAKR-----ALEARLEEAQRGLARLGQEQQTLNRALEEEGK-QREVLRRGKAELEEQKRL 846
Query: 272 VSGQNKRLADPLQK----AREEMSEMQKQLANYERDKQILLCTKARLKV--REKELKDLQ 325
+ RL L+K +++ + ++Q QL +Y+ KAR +V +++ KD
Sbjct: 847 LDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKE--------KARREVADAQRQAKDWA 898
Query: 326 WEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVE-KKEVQ 384
E E +++Q E L R+ A Q + +L ++LQ L E KK Q
Sbjct: 899 SEAEKTSGGLSRLQDEIQRL-RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQ 957
Query: 385 FNEVLAASNLDPAALTLVSRKLEDVLESKNST-------------IKDLQYELAQVCKAH 431
+ L+ VSR ++ E KN+ + L+ EL Q A
Sbjct: 958 DDRARQLKGLEEK----VSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSAR 1013
Query: 432 NDL 434
DL
Sbjct: 1014 QDL 1016
Score = 52.8 bits (125), Expect = 7e-07
Identities = 57/297 (19%), Positives = 126/297 (42%), Gaps = 29/297 (9%)
Query: 29 EQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAE 88
E+ +SR+++E+ R R+ Q ERD E+ ++L+ + E NK R ++
Sbjct: 902 EKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRA 961
Query: 89 ERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVE 148
++K ++KV L TE+ E V L + +R ++ V + ++
Sbjct: 962 R----QLKGLEEKVSRL-------ETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQER 1010
Query: 149 LKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDEL--DLRRKT 206
Q+L + + + K + F++ + ++ + + ++L++ L + R KT
Sbjct: 1011 SARQDLECDKISLERQNKDLKTRLASSEGFQKPSASL-SQLESQNQLLQERLQAEEREKT 1069
Query: 207 ELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLE 266
L + ++ L + E+ + + + ++L + +LK Q+ D E
Sbjct: 1070 VLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLR----VKALKRQV-------DEAE 1118
Query: 267 REMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKD 323
E+ + G K+ +++ E ++Q ++ + E+D KA E LK+
Sbjct: 1119 EEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDS----WRKASRSAAESALKN 1171
Score = 33.9 bits (76), Expect = 0.33
Identities = 28/154 (18%), Positives = 67/154 (43%), Gaps = 14/154 (9%)
Query: 19 DGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELR 78
+G S Q+E ++E L E E+ Q K+ R+++E ++
Sbjct: 1038 EGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKL-------ERKVKELSIQIE 1090
Query: 79 NKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVL 138
++ + + + +++ + +K K++V E + + + + +++H + E L
Sbjct: 1091 DERQHVNDQKDQLSLRVKALKRQVD----EAEEEIERLDGLRKKAQREVEEQHEVNEQ-L 1145
Query: 139 RKDMRALKVE--LKEQELASEVVVKNLRLKHTEE 170
+ +++L+ + K A+E +KN L EE
Sbjct: 1146 QARIKSLEKDSWRKASRSAAESALKNEGLSSDEE 1179
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 73.9 bits (180), Expect = 3e-13
Identities = 78/354 (22%), Positives = 166/354 (46%), Gaps = 51/354 (14%)
Query: 37 RIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIK 96
R EEL +ER+ + +L R+ I T +L++K AEL+ K R E + Q+ +K
Sbjct: 159 RYIEELTKERDALS-LELYRNTI------TNEELKKKNAELQEKLRLAESEKSEIQLNVK 211
Query: 97 VYKQKV---KHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQE 153
K+K+ K LL + Q N + + M ++E R QE +RK +E+
Sbjct: 212 ELKRKLERAKFLLPQVQTNTLQEE------MWRQEEELREQEKKIRKQ--------EEKM 257
Query: 154 LASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEE 213
E ++ K E+ +MR E+++RE E + ++ K LR++ LR + E + +E
Sbjct: 258 WRQEERLREQEGKMREQEEKMRRQ-EKRLREQEKELREQEKELREQKKLREQEEQMQEQE 316
Query: 214 RKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVS 273
K + M+ EE + Q E + ++E + + ++
Sbjct: 317 EKMWEQEEKMREQEE---------------------KMWRQEERLWEQEKQMREQEQKMR 355
Query: 274 GQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQ 333
Q +R+ + ++ RE+ M++Q +E++++ + + R++ REK++++ E E + +
Sbjct: 356 DQEERMWEQDERLREKEERMREQEKMWEQEEK--MQEEERIREREKKMRE---EEETMRE 410
Query: 334 RFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNE 387
+ K+Q++ + ++ + Q+ + + L + K+Q + ++E + +
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 464
Score = 72.0 bits (175), Expect = 1e-12
Identities = 83/398 (20%), Positives = 188/398 (47%), Gaps = 40/398 (10%)
Query: 4 KKKGKKGKAKGTPIVDGLAPEDM--SKEQVEEHVSRIREELDREREERNYFQLERDKIHT 61
K+K ++ K + E+M +E++ E +IR++ ++ + + + K+
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273
Query: 62 FWEITRRQ---LEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKA 118
E RRQ L E++ ELR +++E+ E ++ + E ++ +Q+ K ++E + + E +
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK--MWEQEEKMREQEE 331
Query: 119 EGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDF 178
K+ ++E R+ E K MR + ++++QE + ++ RL+ EE
Sbjct: 332 ------KMWRQEERLWEQ--EKQMREQEQKMRDQE--ERMWEQDERLREKEE-------- 373
Query: 179 ERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYN 238
++RE E ++++ KM +E R+ ++ E EE Q + ++ E + + +
Sbjct: 374 --RMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 431
Query: 239 DITL----NNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQ 294
L L ++EQ E + ++E+ + R+ E+ GQ K++ +K RE+ +M
Sbjct: 432 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI-RDQEEMWGQEKKMWRQ-EKMREQEDQMW 489
Query: 295 KQLANYERDKQILLCTKARL-----KVREKELKDLQWEHEVLEQRFTKVQQERDELYRKF 349
+Q +Q + + R+ ++REKE + E + + Q+ K+++E+ ++
Sbjct: 490 EQEEKMRDQEQKMWDQEERMWEQDERLREKE--ERMREQKKMWQQEEKMREEKKTQEQEK 547
Query: 350 TAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNE 387
QE + + + E+K++ + ++E + E
Sbjct: 548 KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 585
Score = 72.0 bits (175), Expect = 1e-12
Identities = 83/376 (22%), Positives = 165/376 (43%), Gaps = 20/376 (5%)
Query: 24 EDMSKEQVEEHVSRIREEL-DREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDR 82
E+ +EQ EE + R E L ++E++ R Q RD+ WE R L EK+ +R +++
Sbjct: 323 EEKMREQ-EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER-LREKEERMREQEK 380
Query: 83 EMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDM 142
M E EE+ Q E ++ +++ K E E K + Q+E Q+ L +
Sbjct: 381 -MWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 439
Query: 143 RALKVELKEQELASEVVVKNLRLKHTEEI----------TRMRNDFERQVREIEAKYDKK 192
L + K QE ++ + +++ EE+ +MR ++ + E D++
Sbjct: 440 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 499
Query: 193 MKMLRDELDLRRKTE-LHEVEERKNGQIHTLMQR---HEEAFTDIKNYYNDITLNNLALI 248
KM E + + E L E EER Q Q EE T + +
Sbjct: 500 QKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE 559
Query: 249 NSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILL 308
++E+ + MR++E+ + + ++ Q +++ + +K E+ +MQ+Q ++ +
Sbjct: 560 ERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619
Query: 309 CTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLE 368
+ K++E+E ++ WE E Q + E++E R+ ++E ++K + +
Sbjct: 620 EQEEEDKMQEQE--EMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR 677
Query: 369 RKLQALSAAVEKKEVQ 384
+ + + EK Q
Sbjct: 678 EQEEKMQGQEEKMREQ 693
Score = 65.9 bits (159), Expect = 8e-11
Identities = 64/356 (17%), Positives = 162/356 (45%), Gaps = 40/356 (11%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQ-----LEEKKAELRNKDR 82
+E++ E ++REE + RE+ Q + + + WE ++ L E+K +L +++
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENM---WEQEEKEWQQQRLPEQKEKLWEQEK 447
Query: 83 EMEEAEERHQVEIKVYKQKV----------KHLLYEHQNNLTEMKAE-GTVVMKLAQKEH 131
E+ E+ + E K+ Q+ + + E ++ + E + + K+ +E
Sbjct: 448 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 507
Query: 132 RIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDK 191
R+ E R +R + ++EQ+ + K K T+E + D E ++RE E ++
Sbjct: 508 RMWEQDER--LREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565
Query: 192 KMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDI--KNYYNDITLNNLALIN 249
+ KM +E +R + E + +E K + M EE + K + + + +
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625
Query: 250 SLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLC 309
++EQ E M ++E+ ++ + ++ Q +++ + +K RE+ +MQ Q ++ +
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685
Query: 310 TKARLKVREKELK-----------------DLQWEHEVLEQRFTKVQQERDELYRK 348
+ +++ +E++++ + W E + ++ +++ +++++ +
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQER 741
Score = 57.0 bits (136), Expect = 4e-08
Identities = 54/281 (19%), Positives = 123/281 (43%), Gaps = 47/281 (16%)
Query: 28 KEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEA 87
+E++ E R+RE+ +R RE++ W+ + EEKK + + K +E
Sbjct: 506 EERMWEQDERLREKEERMREQKK-----------MWQQEEKMREEKKTQEQEKKTWDQEE 554
Query: 88 EERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKV 147
+ R + ++ ++K M+ E ++ + +K +E + ++ + +
Sbjct: 555 KMREEERMREREKK--------------MREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 148 ELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTE 207
E K QE ++ + ++ EE +M+ E + E +++ KM E +R + E
Sbjct: 601 EEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE 660
Query: 208 -LHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLE 266
+ E EE+ GQ + ++ E+ ++EQ E MR +E+ +
Sbjct: 661 KMREQEEKMQGQEEKMREQEEKM---------------QGQEEKMREQEEKMRGQEEKMW 705
Query: 267 REMAEVSGQNKR------LADPLQKAREEMSEMQKQLANYE 301
+ ++ GQ ++ + + ++ R++ +MQ++L +E
Sbjct: 706 GQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Score = 36.2 bits (82), Expect = 0.067
Identities = 34/163 (20%), Positives = 71/163 (43%)
Query: 220 HTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRL 279
H R+ E T ++ + N LK++ ++++K E E +E+ K L
Sbjct: 154 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKEL 213
Query: 280 ADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQ 339
L++A+ + ++Q E +Q + K+R++E K + E + EQ +
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273
Query: 340 QERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKE 382
QE ++ QE + + K L ++KL+ ++++E
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQE 316
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 73.9 bits (180), Expect = 3e-13
Identities = 89/443 (20%), Positives = 197/443 (44%), Gaps = 70/443 (15%)
Query: 25 DMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREM 84
+ + + + +S+ EE RE+ +R Q E+D + ++QLEEK ++ +++
Sbjct: 1457 EKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKV 1516
Query: 85 EEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRA 144
E Q +I + K + L + + L +++A K+ +E + E M
Sbjct: 1517 VSLEAELQ-DISSQESKDEASLAKVKKQLRDLEA------KVKDQEEELDEQAGTIQM-- 1567
Query: 145 LKVELKEQELASEVVVKNLRLKHT-------EEITRMRNDFERQVR----EIEAKYDKKM 193
L++ +L E+ ++ +R H+ EE+ R +++++ ++E +Y+ K
Sbjct: 1568 ----LEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 194 KMLRDELDLRRKTEL---------HEVEERKNGQIH---------TLMQRH-------EE 228
K+LR++ +L K E E+R + LM H +
Sbjct: 1624 KVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKR 1683
Query: 229 AFTDIKNYYNDITLNNLALINSLKE----------QMEDMRKKEDHLEREMAEVSGQNKR 278
+KN + A + + K Q++D+ K + LE +++ + +
Sbjct: 1684 EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNE 1743
Query: 279 LADPLQKAREEMSEMQKQ----LANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQR 334
+ + L++ +E+M+E+ K+ +A RD + +A+L+ KE ++LQ + + L+ +
Sbjct: 1744 IQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQ 1803
Query: 335 FTKVQQER--DELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAA----VEKKEVQFNEV 388
++Q L + A I+E++ + F+ ++R L++L++ +EK + ++
Sbjct: 1804 VEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKR-LESLASRLKENMEKLTEERDQR 1862
Query: 389 LAASNLDPAALTLVSRKLEDVLE 411
+AA N + + R+L D E
Sbjct: 1863 IAAENREKEQNKRLQRQLRDTKE 1885
Score = 64.3 bits (155), Expect = 2e-10
Identities = 85/435 (19%), Positives = 192/435 (44%), Gaps = 47/435 (10%)
Query: 26 MSKEQV---EEHVSRIREELDREREERNYFQLERDKIHT-FWEITRRQLEEKKAELRNKD 81
+S+EQ+ +E + ++R +L++ +ERN +L D++ + E+T +E+
Sbjct: 1251 LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQ 1310
Query: 82 REMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESV---- 137
E ER + E ++ + + ++ + Q + EM+ +++ A+ + +
Sbjct: 1311 LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 1370
Query: 138 --LRKDMRALKVELKEQELASEVVVK-NLRLKHTEEITRMRNDFE-------RQVREIEA 187
L+ + +V+ ++ L E K + ++ ++ R D + R +++++
Sbjct: 1371 WRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKK 1430
Query: 188 KYDKKMKMLRD-ELDLR-RKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNL 245
K + L+D +L L ++ HE+E+++ L Q HEEA + ++
Sbjct: 1431 KCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDM 1490
Query: 246 ALIN--SLKEQMED-------MRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ 296
L SLK+Q+E+ +K LE E+ ++S Q K +++++KQ
Sbjct: 1491 LLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQES-------KDEASLAKVKKQ 1543
Query: 297 LANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEV 356
L + E A++K +E+EL + ++LEQ +++ E + + + + ++
Sbjct: 1544 LRDLE----------AKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1593
Query: 357 QQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAAS-NLDPAALTLVSRKLEDVLESKNS 415
++ ++KL+ + +E++ +VL L+ TL + ES+
Sbjct: 1594 DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1653
Query: 416 TIKDLQYELAQVCKA 430
KDL+ A + A
Sbjct: 1654 LRKDLKRTKALLADA 1668
Score = 57.0 bits (136), Expect = 4e-08
Identities = 86/365 (23%), Positives = 158/365 (43%), Gaps = 71/365 (19%)
Query: 25 DMSKEQVEEHVSRIREELDREREERNY----------FQLER---DKIHTFWEITRRQLE 71
+M E++ + S+ E D E EE QLE DK E +R+LE
Sbjct: 1576 EMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE--KRELE 1633
Query: 72 EKKAELRNK-DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKE 130
K A L ++ +R E+E+R + ++K + K LL + Q L +K ++AQ +
Sbjct: 1634 GKLATLSDQVNRRDFESEKRLRKDLK----RTKALLADAQLMLDHLKNSAPSKREIAQLK 1689
Query: 131 HRIQESVLR-----KDMRALKVELKEQELASEVVVKNLRLKHTEEITRM---RNDFERQV 182
++++ES K +A++VE+++ L + + K + E+++R+ +N+ + ++
Sbjct: 1690 NQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAK-AKTALEEQLSRLQREKNEIQNRL 1748
Query: 183 REIEAKYDKKMKM-----------------LRDELDL--RRKTELHEVEERKNGQIH--- 220
E + ++ MK L+ +L+ + K EL E + Q+
Sbjct: 1749 EEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLE 1808
Query: 221 ------TLMQRHEEAFTDIKNY--YNDITLNNL-ALINSLKEQMEDMRKKEDHLEREMAE 271
+L+ R E +++ + + L +L + LKE ME + ++ D
Sbjct: 1809 QSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENR 1868
Query: 272 VSGQNKRLADPLQKAREEMSEMQKQLANYERDKQIL-----------LCTKARLKVREKE 320
QNKRL L+ +EEM E+ ++ A R K L +A LK+ K
Sbjct: 1869 EKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKR 1928
Query: 321 LKDLQ 325
+ DLQ
Sbjct: 1929 IGDLQ 1933
Score = 30.4 bits (67), Expect = 3.7
Identities = 23/96 (23%), Positives = 47/96 (48%), Gaps = 1/96 (1%)
Query: 1 MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIH 60
M K + +AK + L E +++E SR++E +++ EER+ ++
Sbjct: 1811 MVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREK 1870
Query: 61 TFWEITRRQLEEKKAELRNKDR-EMEEAEERHQVEI 95
+ +RQL + K E+ R E E + ++H++E+
Sbjct: 1871 EQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEM 1906
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 73.9 bits (180), Expect = 3e-13
Identities = 89/443 (20%), Positives = 197/443 (44%), Gaps = 70/443 (15%)
Query: 25 DMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREM 84
+ + + + +S+ EE RE+ +R Q E+D + ++QLEEK ++ +++
Sbjct: 1457 EKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKV 1516
Query: 85 EEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRA 144
E Q +I + K + L + + L +++A K+ +E + E M
Sbjct: 1517 VSLEAELQ-DISSQESKDEASLAKVKKQLRDLEA------KVKDQEEELDEQAGTIQM-- 1567
Query: 145 LKVELKEQELASEVVVKNLRLKHT-------EEITRMRNDFERQVR----EIEAKYDKKM 193
L++ +L E+ ++ +R H+ EE+ R +++++ ++E +Y+ K
Sbjct: 1568 ----LEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 194 KMLRDELDLRRKTEL---------HEVEERKNGQIH---------TLMQRH-------EE 228
K+LR++ +L K E E+R + LM H +
Sbjct: 1624 KVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKR 1683
Query: 229 AFTDIKNYYNDITLNNLALINSLKE----------QMEDMRKKEDHLEREMAEVSGQNKR 278
+KN + A + + K Q++D+ K + LE +++ + +
Sbjct: 1684 EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNE 1743
Query: 279 LADPLQKAREEMSEMQKQ----LANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQR 334
+ + L++ +E+M+E+ K+ +A RD + +A+L+ KE ++LQ + + L+ +
Sbjct: 1744 IQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQ 1803
Query: 335 FTKVQQER--DELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAA----VEKKEVQFNEV 388
++Q L + A I+E++ + F+ ++R L++L++ +EK + ++
Sbjct: 1804 VEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKR-LESLASRLKENMEKLTEERDQR 1862
Query: 389 LAASNLDPAALTLVSRKLEDVLE 411
+AA N + + R+L D E
Sbjct: 1863 IAAENREKEQNKRLQRQLRDTKE 1885
Score = 64.3 bits (155), Expect = 2e-10
Identities = 85/435 (19%), Positives = 192/435 (44%), Gaps = 47/435 (10%)
Query: 26 MSKEQV---EEHVSRIREELDREREERNYFQLERDKIHT-FWEITRRQLEEKKAELRNKD 81
+S+EQ+ +E + ++R +L++ +ERN +L D++ + E+T +E+
Sbjct: 1251 LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQ 1310
Query: 82 REMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESV---- 137
E ER + E ++ + + ++ + Q + EM+ +++ A+ + +
Sbjct: 1311 LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGE 1370
Query: 138 --LRKDMRALKVELKEQELASEVVVK-NLRLKHTEEITRMRNDFE-------RQVREIEA 187
L+ + +V+ ++ L E K + ++ ++ R D + R +++++
Sbjct: 1371 WRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKK 1430
Query: 188 KYDKKMKMLRD-ELDLR-RKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNL 245
K + L+D +L L ++ HE+E+++ L Q HEEA + ++
Sbjct: 1431 KCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDM 1490
Query: 246 ALIN--SLKEQMED-------MRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ 296
L SLK+Q+E+ +K LE E+ ++S Q K +++++KQ
Sbjct: 1491 LLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQES-------KDEASLAKVKKQ 1543
Query: 297 LANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEV 356
L + E A++K +E+EL + ++LEQ +++ E + + + + ++
Sbjct: 1544 LRDLE----------AKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1593
Query: 357 QQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAAS-NLDPAALTLVSRKLEDVLESKNS 415
++ ++KL+ + +E++ +VL L+ TL + ES+
Sbjct: 1594 DEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1653
Query: 416 TIKDLQYELAQVCKA 430
KDL+ A + A
Sbjct: 1654 LRKDLKRTKALLADA 1668
Score = 57.0 bits (136), Expect = 4e-08
Identities = 86/365 (23%), Positives = 158/365 (43%), Gaps = 71/365 (19%)
Query: 25 DMSKEQVEEHVSRIREELDREREERNY----------FQLER---DKIHTFWEITRRQLE 71
+M E++ + S+ E D E EE QLE DK E +R+LE
Sbjct: 1576 EMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE--KRELE 1633
Query: 72 EKKAELRNK-DREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKE 130
K A L ++ +R E+E+R + ++K + K LL + Q L +K ++AQ +
Sbjct: 1634 GKLATLSDQVNRRDFESEKRLRKDLK----RTKALLADAQLMLDHLKNSAPSKREIAQLK 1689
Query: 131 HRIQESVLR-----KDMRALKVELKEQELASEVVVKNLRLKHTEEITRM---RNDFERQV 182
++++ES K +A++VE+++ L + + K + E+++R+ +N+ + ++
Sbjct: 1690 NQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAK-AKTALEEQLSRLQREKNEIQNRL 1748
Query: 183 REIEAKYDKKMKM-----------------LRDELDL--RRKTELHEVEERKNGQIH--- 220
E + ++ MK L+ +L+ + K EL E + Q+
Sbjct: 1749 EEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLE 1808
Query: 221 ------TLMQRHEEAFTDIKNY--YNDITLNNL-ALINSLKEQMEDMRKKEDHLEREMAE 271
+L+ R E +++ + + L +L + LKE ME + ++ D
Sbjct: 1809 QSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENR 1868
Query: 272 VSGQNKRLADPLQKAREEMSEMQKQLANYERDKQIL-----------LCTKARLKVREKE 320
QNKRL L+ +EEM E+ ++ A R K L +A LK+ K
Sbjct: 1869 EKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKR 1928
Query: 321 LKDLQ 325
+ DLQ
Sbjct: 1929 IGDLQ 1933
Score = 30.4 bits (67), Expect = 3.7
Identities = 23/96 (23%), Positives = 47/96 (48%), Gaps = 1/96 (1%)
Query: 1 MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIH 60
M K + +AK + L E +++E SR++E +++ EER+ ++
Sbjct: 1811 MVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREK 1870
Query: 61 TFWEITRRQLEEKKAELRNKDR-EMEEAEERHQVEI 95
+ +RQL + K E+ R E E + ++H++E+
Sbjct: 1871 EQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEM 1906
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 73.9 bits (180), Expect = 3e-13
Identities = 85/377 (22%), Positives = 172/377 (45%), Gaps = 36/377 (9%)
Query: 72 EKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLT-------EMKAE-GTVV 123
E K +R KD ++++ +E Q E K K+K L + LT EMKA+ GTV+
Sbjct: 63 ELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVL 122
Query: 124 MKLAQKEHRI---QESVLRKDMRALKVELKEQELASEVVVKNLRLKHTE-------EITR 173
Q E ++ +S ++M K++ K QE E ++ L+ + T+ + +
Sbjct: 123 PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE--KEELISTLQAQLTQAQAEQPAQSST 180
Query: 174 MRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDI 233
+F ++++ K + + + + +V K+ + T ++ HE+ +
Sbjct: 181 EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL 240
Query: 234 KNYYNDITLNNLALINSLKEQMEDMRKK-------EDHLEREMAEVSGQNKRLADPLQKA 286
D+ + L+ ++E+ + D L++E+ +N+ L+ LQ+
Sbjct: 241 VT-QADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQM 299
Query: 287 REEMSEMQKQLANYERDKQILLCTKARLKVREKELK--DLQWEHEVLEQRFTKVQQERDE 344
E + ++ + ER++ +L K L+V E++L +LQ E L ++F + Q + E
Sbjct: 300 EAEHNTLRNTVET-EREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAE 358
Query: 345 LYRKFTAAIQ----EVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALT 400
L +++A Q E+++KT L L++ Q L +A + + Q +++L N
Sbjct: 359 LESRYSALEQKHKAEMEEKTS-HILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSA 417
Query: 401 LVSRKLEDVLESKNSTI 417
++LED L+ K+ I
Sbjct: 418 QTIQQLEDQLQQKSKEI 434
Score = 61.2 bits (147), Expect = 2e-09
Identities = 81/436 (18%), Positives = 173/436 (39%), Gaps = 56/436 (12%)
Query: 29 EQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAE 88
+++E +++ E+L E + + + + +++E K + R++ +
Sbjct: 2563 KELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQ 2622
Query: 89 ER-----HQVEIKVYKQKVKHL---LYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRK 140
E + ++KV +++V L Q + E++ E V K A K+ E L+K
Sbjct: 2623 EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK 2682
Query: 141 DMRALK------------VELKEQELASEVVVKNLRL----KHTEEITRMRNDFERQVRE 184
+++ L E + ELA ++V +L K + +T F R +
Sbjct: 2683 ELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS 2742
Query: 185 IEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTD----IKNYYNDI 240
++ D + L DEL + L E+ + K L+ R +A N +
Sbjct: 2743 LQNSRDHANEEL-DELKRKYDASLKELAQLKE---QGLLNRERDALLSETAFSMNSTEEN 2798
Query: 241 TLNNLALINS-----------LKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREE 289
+L++L +N L Q+ED + + MA + + L + L+K R+
Sbjct: 2799 SLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS 2858
Query: 290 MSEMQKQLANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKF 349
Q+ A + K + + + L E + L+Q++ ++ QE EL+
Sbjct: 2859 EEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH-PL 2917
Query: 350 TAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLED- 408
A +QE Q KT + Q + + ++ + + L ++ ++ + R++++
Sbjct: 2918 KAQLQEYQDKT--------KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQ 2969
Query: 409 ---VLESKNSTIKDLQ 421
+ K+ + LQ
Sbjct: 2970 YLMAISDKDQQLSHLQ 2985
Score = 60.8 bits (146), Expect = 3e-09
Identities = 91/481 (18%), Positives = 205/481 (42%), Gaps = 82/481 (17%)
Query: 26 MSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLE-------------- 71
+ E +E + +++ + EE+ E+ K+ + EI + LE
Sbjct: 1949 IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVES--EIRKEYLEKIQGAQKEPGNKSH 2006
Query: 72 --EKKAELRNKDREMEEAEE---RHQVEIKVYKQKVKHLLY---EHQNNLTEMKAEGTVV 123
E + L+ K +E+++ ++ R+Q +I ++ VK L + E Q +L K
Sbjct: 2007 AKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKEN---- 2062
Query: 124 MKLAQK-EHRIQESVLRKDMRALKVELKE-QELASEVVVKNLRLKHT---------EEIT 172
LAQ EHR + ++ + KV L + Q A+ V+ NL+LK ++
Sbjct: 2063 --LAQAVEHRKKAQA---ELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMK 2117
Query: 173 RMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTD 232
+ D ER++ + E K+ K+ K ++++LD R+ ++H E G+I + + ++
Sbjct: 2118 QKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH--LEETIGEIQVTLNKKDKEVQQ 2175
Query: 233 IKNYYNDITLNNLALINSLKEQMED------------MRKKEDHLEREMAEVSGQNKR-- 278
++ D T+ LA ++D RK D ++ + E+ +
Sbjct: 2176 LQENL-DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234
Query: 279 -LADPLQKAREEMSEMQKQLANYERDKQILLC-TKARLKVREKELKDLQWEHEVL----- 331
L D L++ M E++ ++ E DKQI + +++++K LQ E++ L
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLE 2294
Query: 332 ---------EQRFTKVQQERDELYRKFTAAIQEV----QQKTGFKNLVLERKLQALSAAV 378
+ K++ E L + T + +QK + ++ +++ ++
Sbjct: 2295 ETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKF 2354
Query: 379 EKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTY 438
++++ ++ A+ L ++ K + ++ + + +Q +A++ + H+ ++
Sbjct: 2355 SYEQLE-TDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKEL 2413
Query: 439 E 439
E
Sbjct: 2414 E 2414
Score = 60.1 bits (144), Expect = 4e-09
Identities = 104/481 (21%), Positives = 194/481 (40%), Gaps = 100/481 (20%)
Query: 32 EEHVSRIREELDR-----EREERNYFQLERDKIHTFWEI---TRRQLEEKKAEL---RNK 80
E++ S ++++L + E + N +LE DK WE T QL++K + NK
Sbjct: 2230 EDNCSVLKDQLRQMSIHMEELKINISRLEHDK--QIWESKAQTEVQLQQKVCDTLQGENK 2287
Query: 81 DREMEEAEERH-----QVEIKVYKQKVKHL---LYEHQNNLTEMKAE-GTVVMKLAQKEH 131
+ + E RH Q E+ + ++K L L + N+L + K + G + + Q+E
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 132 RIQESV-----LRKDMRALK---------VELKEQELAS---------EVVVKNLRLKHT 168
IQ S L D++A + + +KEQ++ S +V + LR +H
Sbjct: 2348 DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD 2407
Query: 169 EEITRMRN--------------------DFERQVREIEAKYDKKMKMLRDELD--LRRKT 206
+EI + N D Q+ E K+ + +LD ++ +
Sbjct: 2408 KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMS 2467
Query: 207 ELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLE 266
L +R G L +RH + + N N LKE++ +R D L
Sbjct: 2468 SLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAEN----NKLKEEIRGLRSHMDDLN 2523
Query: 267 REMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKDLQW 326
E A++ + + + L + QKQL L+V+ ++ K+L+
Sbjct: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQL----------------LEVQLQQNKELEN 2567
Query: 327 EHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEK--KEVQ 384
++ LE++ + ++ ++L R F A +E Q L +++++L ++ + ++V
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQD--------LSKEIESLKVSISQLTRQVT 2619
Query: 385 FNEVLAASNLDPAALTLVS---RKLEDVLESKNSTIKDLQYELAQVCKAHNDLLRTYEAK 441
+ L A L + +L + S I +L+ EL V K + E K
Sbjct: 2620 ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDK 2679
Query: 442 L 442
L
Sbjct: 2680 L 2680
Score = 58.2 bits (139), Expect = 2e-08
Identities = 93/442 (21%), Positives = 183/442 (41%), Gaps = 63/442 (14%)
Query: 24 EDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLE--EKKAELRNKD 81
ED S Q V++I+ +L E+ +LE T E+T++ E + + ++ +
Sbjct: 1293 EDASALQGGTSVAQIKAQLKEIEAEK--VELELKVSSTTSELTKKSEEVFQLQEQINKQG 1350
Query: 82 REMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKD 141
E+E + E +V+ + ++ L Q + ++ + KL + + I + +D
Sbjct: 1351 LEIESLKTVSH-EAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKK--EED 1407
Query: 142 MRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDEL- 200
+ L +L E+E A + + ++ + I + E Q +E +D+++K L+ EL
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEI-IEQEDLIKALHTQLEMQAKE----HDERIKQLQVELC 1462
Query: 201 DLRRKTELHEVEERKNGQIHTLMQR----HEEAFTDIKNYYNDITLNNLALINSLKEQME 256
++++K E E R QI +Q +EA + K+ +++L I L + +
Sbjct: 1463 EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLAR-GTIERLTKSLA 1521
Query: 257 DMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSE--------------MQKQLANYER 302
D+ + +E V G+ L + K EM ++ L
Sbjct: 1522 DVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTE 1581
Query: 303 DKQILLCTKARLKVR--------EKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQ 354
DK+ L+ LK +++ K+LQ E+E+L Q + V E + + A Q
Sbjct: 1582 DKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQ 1641
Query: 355 EVQQKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKN 414
E Q+ G KL++ A ++ E Q E +++E++ E
Sbjct: 1642 EKQELYG--------KLRSTEANKKETEKQLQE--------------AEQEMEEMKEKMR 1679
Query: 415 STIKDLQYELAQVCKAHNDLLR 436
K Q ++ ++ + ND LR
Sbjct: 1680 KFAKSKQQKILEL-EEENDRLR 1700
Score = 56.6 bits (135), Expect = 5e-08
Identities = 88/444 (19%), Positives = 193/444 (43%), Gaps = 75/444 (16%)
Query: 45 EREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEE---------------AEE 89
ER + +LE + H EI + L+EK E+ N ++ +EE +EE
Sbjct: 687 ERLKSQILELELN-FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE 745
Query: 90 RHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVEL 149
R Q+ +V + + L L AE +L + +++L + + +L +E
Sbjct: 746 RDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEA 805
Query: 150 KEQELASEVV---VKNLRLKHTEEITRMRN-------------DFERQVREIEAKYDKKM 193
K +++ EV+ + +++L+ +E+ T +R+ + +VR I +K ++
Sbjct: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
Query: 194 KML-RDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLAL----- 247
+ L + EL++ T++ ++ K + TL Q EE + +T + L
Sbjct: 866 QALSQKELEI---TKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
Query: 248 -----INSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMS---EMQKQLAN 299
I +LKEQ+ + + E+ + ++ E + ++ L++ +EMS ++ K+
Sbjct: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEE----DNEVSSGLKQNYDEMSPAGQISKEELQ 978
Query: 300 YERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQE----RDELYRKFTAA--- 352
+E D K + R+++L+ + L QR +++++E +DE ++ +
Sbjct: 979 HEFD-----LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETE 1033
Query: 353 ---IQEVQQKTGFKNLVLERKLQA----LSAAVEKKEVQFNEVLAASNLDPAA---LTLV 402
++E ++ + + K Q L + +KEV+ + AA +
Sbjct: 1034 RGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQAL 1093
Query: 403 SRKLEDVLESKNSTIKDLQYELAQ 426
+++ L+ K + I LQ E+++
Sbjct: 1094 VKQMNQTLQDKTNQIDLLQAEISE 1117
Score = 54.3 bits (129), Expect = 2e-07
Identities = 67/325 (20%), Positives = 136/325 (41%), Gaps = 74/325 (22%)
Query: 68 RQLEEKKAELRNKDREM-EEAEERHQVEIKVYKQKV--KHLLYEHQNNLTEMK-AEGTV- 122
+QL+ + E++ K E+ EE+ + Q++ K+ + K L E+++ E+ A GT+
Sbjct: 1455 KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
Query: 123 --VMKLAQKEHRIQESVLRKDMRALKVELKEQE---LASEV---VVKNLRLKHTEEITRM 174
LA E ++ KD ++ L ++E L +E+ +++N L + E ++
Sbjct: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574
Query: 175 R-----NDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEA 229
D E+ V+EIE+ K + TE E + + L+Q +E
Sbjct: 1575 ALEGLTEDKEKLVKEIESLKSSK---------IAESTEWQEKHKELQKEYEILLQSYENV 1625
Query: 230 FTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREE 289
+ + ++ +E +R+++ L ++ K LQ+A +E
Sbjct: 1626 SNEAER---------------IQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQE 1670
Query: 290 MSEMQKQLANYERDKQ-----------------------------ILLCTKARLKVREKE 320
M EM++++ + + KQ LL + A +K +E
Sbjct: 1671 MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMK---EE 1727
Query: 321 LKDLQWEHEVLEQRFTKVQQERDEL 345
L+ ++ E+E L ++F + E+D L
Sbjct: 1728 LERVKMEYETLSKKFQSLMSEKDSL 1752
Score = 51.6 bits (122), Expect = 2e-06
Identities = 103/503 (20%), Positives = 198/503 (39%), Gaps = 102/503 (20%)
Query: 27 SKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEE 86
S E V RI+ ++ R+E+ +++ T +E + +L+ ++EMEE
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQ-------ELYGKLRSTEANKKETEKQLQEAEQEMEE 1673
Query: 87 AEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMK----LAQKEHRIQESVLRKDM 142
+E+ + K +QK+ L E+ E+ G + L ++E + R M
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM 1733
Query: 143 RALKVELKEQELASEV-----------------VVKNLRLKHTEEITRMRNDFERQVREI 185
+ K Q L SE V K L+ TE+ N E + I
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Query: 186 EAKYDKKMKM---------------------------LRDELD--------LRRKTELHE 210
+ +++ + DE++ L+ + E
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 211 VEERKNGQI--------HTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKE 262
E++KN + +TL+ + ++K ++T NL L ++E++ + K +
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNL-LNQQIQEELSRVTKLK 1912
Query: 263 DHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERD------KQILLCTKARLKV 316
+ E E ++ ++ +++E+ + NY +D K LL ++ +K
Sbjct: 1913 ETAEEEKDDLE----------ERLMNQLAELNGSIGNYCQDVTDAQIKNELL--ESEMKN 1960
Query: 317 REKELKDLQWEHEVLEQRFTKVQQE-RDELYRKFTAAIQEVQQKTGFKNL--VLERKLQA 373
+K + +L+ E + L + TKV+ E R E K A +E K+ K L +L+ K Q
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
Query: 374 LSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKNSTI-------KDLQYELAQ 426
+ ++K +++ E ++A AL V + + LE + K Q ELA
Sbjct: 2021 VK-QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079
Query: 427 VCKAHNDLLRTYEAKLLAFGIPL 449
K D ++ A++LA + L
Sbjct: 2080 F-KVLLDDTQSEAARVLADNLKL 2101
Score = 41.2 bits (95), Expect = 0.002
Identities = 83/449 (18%), Positives = 184/449 (40%), Gaps = 50/449 (11%)
Query: 17 IVDGLAPEDMSKEQVEEHVSRIREELDREREE-RNYFQLERDKIHTFWEITRRQLEEKKA 75
+VD L E + EQ + +S+ ++++ E RN + ER++ E ++ E+K
Sbjct: 274 VVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKL 333
Query: 76 ELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQE 135
N EM E+ + + + Q + EM+ + + ++ L + +Q
Sbjct: 334 SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQS 393
Query: 136 S--VLRKDMRALKVELKEQELASEVVVKNLR---LKHTEEITRMRNDFERQVREIEAK-- 188
+ L+ L + EQ + S ++ L + ++EI++ N Q E ++
Sbjct: 394 ACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTS 453
Query: 189 ----YDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNN 244
Y++ + + +E + + E+E K + + ++ EE + + + ITL
Sbjct: 454 FPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIEL-EELKAENEKLSSQITL-- 510
Query: 245 LALINSLKEQMEDMRKKEDHLEREMAEVS---GQNKRLADPLQKAREEM----SEMQKQL 297
+ + + +RE++E+S NKR + + ++ + S+ K+L
Sbjct: 511 -----------LEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKEL 559
Query: 298 ANYERDKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQ 357
+ + + A LK++ + + + +HEVL+Q+ K + K +++
Sbjct: 560 SVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTG 619
Query: 358 QKTGFKNLVLERKLQALSAAVEKKEVQFNEVLAAS---NLDPAALTLVSRKLEDVLESKN 414
Q + L ++ AVEK++ S +L+ A + L S K + +
Sbjct: 620 Q-----DFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDG--DKSL 672
Query: 415 STIKDLQYELAQVCKAHNDLLRTYEAKLL 443
S + D + + H D L ++++L
Sbjct: 673 SAVPD-------IGQCHQDELERLKSQIL 694
Score = 40.0 bits (92), Expect = 0.005
Identities = 79/435 (18%), Positives = 161/435 (37%), Gaps = 44/435 (10%)
Query: 19 DGLAPE-DMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAEL 77
D ++P +SKE+++ +++E ++ + + + R ++ ++R LEE+ A L
Sbjct: 964 DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL--LQRVSR--LEEELANL 1019
Query: 78 RNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESV 137
+++ ++ E + E++ K+ ++ + +T E + +K E ++
Sbjct: 1020 KDESKKEIPLSETERGEVEEDKENKEY----SEKCVTSKCQEIEIYLKQTISEKEVELQH 1075
Query: 138 LRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLR 197
+RKD+ E++LA+E + L + + + N + EI K++
Sbjct: 1076 IRKDL--------EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLIT 1127
Query: 198 DELDLRRKTELHEVEERK------NGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSL 251
D + V+E G EE ++ + + S
Sbjct: 1128 SNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSR 1187
Query: 252 KEQMEDMRKKEDHLEREMAEVSGQNKRLA---DPLQKAREEMSEMQKQLANYER------ 302
K ++ ++KE HL E+ + RL D K E + + +QL R
Sbjct: 1188 KAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGK 1247
Query: 303 ----DKQILLCTKARLKVREKELKDLQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQ 358
D+Q + L+ + + VLE E Q
Sbjct: 1248 LPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
Query: 359 KTGFKNL-----VLERKLQALSAAVEKKE---VQFNEVLAASNLDPAALTLVSRKLEDVL 410
K K + LE K+ + ++ + KK Q E + L+ +L VS + E
Sbjct: 1308 KAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHA 1367
Query: 411 ESKNSTIKDLQYELA 425
ES ++ Q ++A
Sbjct: 1368 ESLQQKLESSQLQIA 1382
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 73.6 bits (179), Expect = 4e-13
Identities = 76/318 (23%), Positives = 147/318 (46%), Gaps = 42/318 (13%)
Query: 26 MSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREME 85
+ +E+ E + REE +R+R+E Q E EI RRQ EE++ K RE E
Sbjct: 731 LEQERREAEMRAKREEEERKRQEELRRQQE--------EILRRQQEEER-----KRREEE 777
Query: 86 EAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQK-----EHRIQESVLRK 140
E R Q E + +Q+ + + Q E + + + +L ++ E R QE +LRK
Sbjct: 778 ELARRKQEE-ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 836
Query: 141 DMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDEL 200
+E+E A + +N RL+ EE R+R++ E + R+ EL
Sbjct: 837 QEEEAAKWAREEEEAQRRLEEN-RLRMEEEAARLRHEEEERKRK--------------EL 881
Query: 201 DLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDIT----LNNLALINSLKEQME 256
+++R+ EL +++ + L Q+ ++ + T N A + +
Sbjct: 882 EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLA 941
Query: 257 DMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ-LANYERDKQILLCTKARLK 315
+++K E+ ER++ E + +R L KA ++ + Q+Q L+ + + TK+ L+
Sbjct: 942 EIQKLEEERERQLRE---EQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLE 998
Query: 316 VREKELKDLQWEHEVLEQ 333
++++E + +Q + + +Q
Sbjct: 999 IQQEEARQMQKQQQQQQQ 1016
Score = 52.8 bits (125), Expect = 7e-07
Identities = 57/262 (21%), Positives = 126/262 (48%), Gaps = 12/262 (4%)
Query: 100 QKVKHLLYEHQNNLTEMKAEGTVVMKLAQKE-HRIQESVLRKDMRALKVELKEQELASEV 158
+K K E + EM+A+ + Q+E R QE +LR+ + +E+ELA
Sbjct: 724 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRK 783
Query: 159 VVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQ 218
+ LR + +EI +R E + R+ + + ++++ R E + RRK E E+ ++ +
Sbjct: 784 QEEALRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQE--ELLRKQEEE 840
Query: 219 IHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKR 278
+ EEA ++ N + + A L+ + E+ ++KE ++R+ E+ Q ++
Sbjct: 841 AAKWAREEEEAQRRLEE--NRLRMEEEAA--RLRHEEEERKRKELEVQRQ-KELMRQRQQ 895
Query: 279 LADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK-DLQWEHEVLEQRFTK 337
+ L++ +++ + Q+QLA + ++ + + L ++ E+R +
Sbjct: 896 QQEALRRLQQQ--QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 953
Query: 338 VQQERDELYRKFTAAIQEVQQK 359
+++E+ R+ A+Q+ QQ+
Sbjct: 954 LREEQRRQQRELMKALQQQQQQ 975
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 73.6 bits (179), Expect = 4e-13
Identities = 76/318 (23%), Positives = 147/318 (46%), Gaps = 42/318 (13%)
Query: 26 MSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREME 85
+ +E+ E + REE +R+R+E Q E EI RRQ EE++ K RE E
Sbjct: 758 LEQERREAEMRAKREEEERKRQEELRRQQE--------EILRRQQEEER-----KRREEE 804
Query: 86 EAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQK-----EHRIQESVLRK 140
E R Q E + +Q+ + + Q E + + + +L ++ E R QE +LRK
Sbjct: 805 ELARRKQEE-ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 863
Query: 141 DMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDEL 200
+E+E A + +N RL+ EE R+R++ E + R+ EL
Sbjct: 864 QEEEAAKWAREEEEAQRRLEEN-RLRMEEEAARLRHEEEERKRK--------------EL 908
Query: 201 DLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDIT----LNNLALINSLKEQME 256
+++R+ EL +++ + L Q+ ++ + T N A + +
Sbjct: 909 EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLA 968
Query: 257 DMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ-LANYERDKQILLCTKARLK 315
+++K E+ ER++ E + +R L KA ++ + Q+Q L+ + + TK+ L+
Sbjct: 969 EIQKLEEERERQLRE---EQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLE 1025
Query: 316 VREKELKDLQWEHEVLEQ 333
++++E + +Q + + +Q
Sbjct: 1026 IQQEEARQMQKQQQQQQQ 1043
Score = 52.8 bits (125), Expect = 7e-07
Identities = 57/262 (21%), Positives = 126/262 (48%), Gaps = 12/262 (4%)
Query: 100 QKVKHLLYEHQNNLTEMKAEGTVVMKLAQKE-HRIQESVLRKDMRALKVELKEQELASEV 158
+K K E + EM+A+ + Q+E R QE +LR+ + +E+ELA
Sbjct: 751 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRK 810
Query: 159 VVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQ 218
+ LR + +EI +R E + R+ + + ++++ R E + RRK E E+ ++ +
Sbjct: 811 QEEALRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQE--ELLRKQEEE 867
Query: 219 IHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKR 278
+ EEA ++ N + + A L+ + E+ ++KE ++R+ E+ Q ++
Sbjct: 868 AAKWAREEEEAQRRLEE--NRLRMEEEAA--RLRHEEEERKRKELEVQRQ-KELMRQRQQ 922
Query: 279 LADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK-DLQWEHEVLEQRFTK 337
+ L++ +++ + Q+QLA + ++ + + L ++ E+R +
Sbjct: 923 QQEALRRLQQQ--QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 980
Query: 338 VQQERDELYRKFTAAIQEVQQK 359
+++E+ R+ A+Q+ QQ+
Sbjct: 981 LREEQRRQQRELMKALQQQQQQ 1002
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 73.6 bits (179), Expect = 4e-13
Identities = 76/318 (23%), Positives = 147/318 (46%), Gaps = 42/318 (13%)
Query: 26 MSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREME 85
+ +E+ E + REE +R+R+E Q E EI RRQ EE++ K RE E
Sbjct: 737 LEQERREAEMRAKREEEERKRQEELRRQQE--------EILRRQQEEER-----KRREEE 783
Query: 86 EAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQK-----EHRIQESVLRK 140
E R Q E + +Q+ + + Q E + + + +L ++ E R QE +LRK
Sbjct: 784 ELARRKQEE-ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 842
Query: 141 DMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDEL 200
+E+E A + +N RL+ EE R+R++ E + R+ EL
Sbjct: 843 QEEEAAKWAREEEEAQRRLEEN-RLRMEEEAARLRHEEEERKRK--------------EL 887
Query: 201 DLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDIT----LNNLALINSLKEQME 256
+++R+ EL +++ + L Q+ ++ + T N A + +
Sbjct: 888 EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLA 947
Query: 257 DMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ-LANYERDKQILLCTKARLK 315
+++K E+ ER++ E + +R L KA ++ + Q+Q L+ + + TK+ L+
Sbjct: 948 EIQKLEEERERQLRE---EQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLE 1004
Query: 316 VREKELKDLQWEHEVLEQ 333
++++E + +Q + + +Q
Sbjct: 1005 IQQEEARQMQKQQQQQQQ 1022
Score = 52.8 bits (125), Expect = 7e-07
Identities = 57/262 (21%), Positives = 126/262 (48%), Gaps = 12/262 (4%)
Query: 100 QKVKHLLYEHQNNLTEMKAEGTVVMKLAQKE-HRIQESVLRKDMRALKVELKEQELASEV 158
+K K E + EM+A+ + Q+E R QE +LR+ + +E+ELA
Sbjct: 730 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRK 789
Query: 159 VVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQ 218
+ LR + +EI +R E + R+ + + ++++ R E + RRK E E+ ++ +
Sbjct: 790 QEEALRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQE--ELLRKQEEE 846
Query: 219 IHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKR 278
+ EEA ++ N + + A L+ + E+ ++KE ++R+ E+ Q ++
Sbjct: 847 AAKWAREEEEAQRRLEE--NRLRMEEEAA--RLRHEEEERKRKELEVQRQ-KELMRQRQQ 901
Query: 279 LADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK-DLQWEHEVLEQRFTK 337
+ L++ +++ + Q+QLA + ++ + + L ++ E+R +
Sbjct: 902 QQEALRRLQQQ--QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 959
Query: 338 VQQERDELYRKFTAAIQEVQQK 359
+++E+ R+ A+Q+ QQ+
Sbjct: 960 LREEQRRQQRELMKALQQQQQQ 981
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 73.6 bits (179), Expect = 4e-13
Identities = 76/318 (23%), Positives = 147/318 (46%), Gaps = 42/318 (13%)
Query: 26 MSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREME 85
+ +E+ E + REE +R+R+E Q E EI RRQ EE++ K RE E
Sbjct: 737 LEQERREAEMRAKREEEERKRQEELRRQQE--------EILRRQQEEER-----KRREEE 783
Query: 86 EAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQK-----EHRIQESVLRK 140
E R Q E + +Q+ + + Q E + + + +L ++ E R QE +LRK
Sbjct: 784 ELARRKQEE-ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 842
Query: 141 DMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDEL 200
+E+E A + +N RL+ EE R+R++ E + R+ EL
Sbjct: 843 QEEEAAKWAREEEEAQRRLEEN-RLRMEEEAARLRHEEEERKRK--------------EL 887
Query: 201 DLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDIT----LNNLALINSLKEQME 256
+++R+ EL +++ + L Q+ ++ + T N A + +
Sbjct: 888 EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLA 947
Query: 257 DMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQ-LANYERDKQILLCTKARLK 315
+++K E+ ER++ E + +R L KA ++ + Q+Q L+ + + TK+ L+
Sbjct: 948 EIQKLEEERERQLRE---EQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLE 1004
Query: 316 VREKELKDLQWEHEVLEQ 333
++++E + +Q + + +Q
Sbjct: 1005 IQQEEARQMQKQQQQQQQ 1022
Score = 52.8 bits (125), Expect = 7e-07
Identities = 57/262 (21%), Positives = 126/262 (48%), Gaps = 12/262 (4%)
Query: 100 QKVKHLLYEHQNNLTEMKAEGTVVMKLAQKE-HRIQESVLRKDMRALKVELKEQELASEV 158
+K K E + EM+A+ + Q+E R QE +LR+ + +E+ELA
Sbjct: 730 EKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRK 789
Query: 159 VVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQ 218
+ LR + +EI +R E + R+ + + ++++ R E + RRK E E+ ++ +
Sbjct: 790 QEEALRRQREQEIA-LRRQREEEERQQQEEALRRLEERRREEEERRKQE--ELLRKQEEE 846
Query: 219 IHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKR 278
+ EEA ++ N + + A L+ + E+ ++KE ++R+ E+ Q ++
Sbjct: 847 AAKWAREEEEAQRRLEE--NRLRMEEEAA--RLRHEEEERKRKELEVQRQ-KELMRQRQQ 901
Query: 279 LADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELK-DLQWEHEVLEQRFTK 337
+ L++ +++ + Q+QLA + ++ + + L ++ E+R +
Sbjct: 902 QQEALRRLQQQ--QQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ 959
Query: 338 VQQERDELYRKFTAAIQEVQQK 359
+++E+ R+ A+Q+ QQ+
Sbjct: 960 LREEQRRQQRELMKALQQQQQQ 981
>gi|109134347 NY-REN-58 antigen [Homo sapiens]
Length = 701
Score = 73.6 bits (179), Expect = 4e-13
Identities = 109/484 (22%), Positives = 203/484 (41%), Gaps = 84/484 (17%)
Query: 26 MSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREME 85
++ Q E I E L E + NY L+ + HT +L+ + +L+N+ + +
Sbjct: 24 LTGSQSEFQKMLIDERLRCEHHKANYQTLKAE--HT-------RLQNEHVKLQNELKHLF 74
Query: 86 EAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRAL 145
++ Q ++++ ++++ L E +L EMK + KL +IQ+ L MR
Sbjct: 75 NEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQE-LETPMRER 133
Query: 146 KVELKEQELASEVVVKNLRLKHT---EEITRMRNDFERQVREIEAKYDKKMKMLRDE--- 199
L E+ V LR +HT E + ++ R + E + KY+ ++ L ++
Sbjct: 134 FRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEE 193
Query: 200 -------LDL-----------RRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDIT 241
+DL R K L + + ++ L E + ++N I
Sbjct: 194 LRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQR-IQ 252
Query: 242 LNNL----ALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQL 297
+ L A + SL+ + + + + LE+E+ S QN L + L KA E++ + ++
Sbjct: 253 VRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKV 312
Query: 298 ANYERDKQI----LLCTKARLKVR--------EKELKDLQWEHEVLE-----QRFTKVQQ 340
+ ++ + AR K + EL LQ ++E+L+ + V++
Sbjct: 313 KELKHSNKLEITDIKLETARAKSELERERNKIQSELDGLQSDNEILKAAVEHHKVLLVEK 372
Query: 341 ERDELYRKFTAAIQEVQQKTGF---KNLVLERKLQALSAAVEKKEV-------QFNEVLA 390
+R EL RK AA +E QK + L LE +L L + +V Q+ E L
Sbjct: 373 DR-ELIRKVQAAKEEGYQKLVVLQDEKLELENRLADLEKMKVEHDVWRQSEKDQYEEKLR 431
Query: 391 AS----NLDPAALTLVSRKLEDVL---------ESKNSTIK----DLQYELAQVCKAHND 433
AS + L V KL+ + +++NS +K LQ ++ + ++ ND
Sbjct: 432 ASQMAEEITRKELQSVRLKLQQQIVTIENAEKEKNENSDLKQQISSLQIQVTSLAQSEND 491
Query: 434 LLRT 437
LL +
Sbjct: 492 LLNS 495
Score = 70.9 bits (172), Expect = 2e-12
Identities = 90/418 (21%), Positives = 199/418 (47%), Gaps = 51/418 (12%)
Query: 31 VEEHVSRIREELDREREERNYFQLERDKIHTFWEI--TRRQLEEKK--AELRNK--DREM 84
+E V+ ++ E +E E +R ++ E+ T R LE +K A LR + ++E+
Sbjct: 227 LEAEVAELKAE--KENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKEL 284
Query: 85 EEAEERH----------QVEIKVYKQKVKHLLYEHQNNLTEMKAE-GTVVMKLAQKEHRI 133
+ + E++ + EI KVK L + ++ +T++K E +L ++ ++I
Sbjct: 285 QSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNKLEITDIKLETARAKSELERERNKI 344
Query: 134 QESV--LRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDK 191
Q + L+ D LK ++ ++ L K E I +++ E +++ D+
Sbjct: 345 QSELDGLQSDNEILKAAVEHHKVL-------LVEKDRELIRKVQAAKEEGYQKLVVLQDE 397
Query: 192 KMKM---------LRDELDLRRKTELHEVEER-KNGQIHTLMQRHEEAFTDIKNYYNDIT 241
K+++ ++ E D+ R++E + EE+ + Q+ + R E +K +T
Sbjct: 398 KLELENRLADLEKMKVEHDVWRQSEKDQYEEKLRASQMAEEITRKELQSVRLKLQQQIVT 457
Query: 242 LNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYE 301
+ N K + D++++ L+ ++ ++ L + Q +E + ++++ N+
Sbjct: 458 IENA---EKEKNENSDLKQQISSLQIQVTSLAQSENDLLNSNQMLKEMVERLKQECRNF- 513
Query: 302 RDKQILLCTKARLKVREKELKDLQWEHEVLEQ---RFTKVQQERDELYRKFTAAIQEVQQ 358
R + +A + EK+++ L+ +H++ E+ R K Q +++L R AAI + ++
Sbjct: 514 RSQAEKAQLEAEKTLEEKQIQWLEEKHKLHERITDREEKYNQAKEKLQR---AAIAQKKR 570
Query: 359 KTGFKNLV--LERKLQALSAAVEKKEVQFNEVLAASNLDPAALTLVSRKLEDVLESKN 414
K+ +N + L+ K++ L A E+ E + N+VL N+ T + ++L+D+ N
Sbjct: 571 KSLHENKLKRLQEKVEVLEAKKEELETE-NQVLNRQNVPFEDYTRLQKRLKDIQRRHN 627
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,167,090
Number of Sequences: 37866
Number of extensions: 725599
Number of successful extensions: 11483
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 312
Number of HSP's successfully gapped in prelim test: 1020
Number of HSP's that attempted gapping in prelim test: 4599
Number of HSP's gapped (non-prelim): 4086
length of query: 478
length of database: 18,247,518
effective HSP length: 106
effective length of query: 372
effective length of database: 14,233,722
effective search space: 5294944584
effective search space used: 5294944584
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.