BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 isoform 1 precursor [Homo sapiens] (473 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 962 0.0 gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 909 0.0 gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 772 0.0 gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 754 0.0 gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 745 0.0 gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur... 368 e-102 gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 340 2e-93 gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom... 330 1e-90 gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec... 324 9e-89 gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom... 314 1e-85 gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s... 314 1e-85 gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 293 2e-79 gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 291 1e-78 gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 291 1e-78 gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] 290 1e-78 gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 288 1e-77 gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 286 2e-77 gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 286 2e-77 gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 285 5e-77 gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo... 285 5e-77 gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 279 5e-75 gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr... 278 8e-75 gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 276 2e-74 gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 276 2e-74 gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor... 276 2e-74 gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens] 275 7e-74 gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 271 1e-72 gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso... 268 1e-71 gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform... 265 7e-71 gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 265 7e-71 >gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 isoform 1 precursor [Homo sapiens] Length = 473 Score = 962 bits (2486), Expect = 0.0 Identities = 473/473 (100%), Positives = 473/473 (100%) Query: 1 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP Sbjct: 1 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60 Query: 61 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD Sbjct: 61 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120 Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE Sbjct: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180 Query: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK Sbjct: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240 Query: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI Sbjct: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300 Query: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR Sbjct: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360 Query: 361 VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS 420 VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS Sbjct: 361 VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS 420 Query: 421 LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473 LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN Sbjct: 421 LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473 >gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 isoform 2 precursor [Homo sapiens] Length = 473 Score = 909 bits (2348), Expect = 0.0 Identities = 447/448 (99%), Positives = 448/448 (100%) Query: 26 QSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT 85 +SVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT Sbjct: 26 RSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT 85 Query: 86 MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 145 MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP Sbjct: 86 MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 145 Query: 146 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER 205 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER Sbjct: 146 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER 205 Query: 206 IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF 265 IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF Sbjct: 206 IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF 265 Query: 266 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA 325 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA Sbjct: 266 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA 325 Query: 326 FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI 385 FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI Sbjct: 326 FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI 385 Query: 386 GDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDV 445 GDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDV Sbjct: 386 GDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDV 445 Query: 446 NAIDRWSRIVFPFTFSLFNLVYWLYYVN 473 NAIDRWSRIVFPFTFSLFNLVYWLYYVN Sbjct: 446 NAIDRWSRIVFPFTFSLFNLVYWLYYVN 473 >gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 isoform 2 [Homo sapiens] Length = 474 Score = 772 bits (1994), Expect = 0.0 Identities = 379/475 (79%), Positives = 420/475 (88%), Gaps = 3/475 (0%) Query: 1 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60 MW + FGI+S P+++A VC AQSVNDP NMS VKETVD+LLKGYDIRLRPDFGGPP Sbjct: 1 MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP 59 Query: 61 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120 V VGMNIDIASIDMVSEVNMDYTLTMYFQQ WRDKRL+Y+ IPLNLTLDNRVADQLWVPD Sbjct: 60 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD 119 Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE Sbjct: 120 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 179 Query: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240 SYGYTTDDIEFYWRG D AVTGV +IELPQFSIV+++L+++ VVF+TG+YPRLSLSF+LK Sbjct: 180 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK 239 Query: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI Sbjct: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299 Query: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360 PYVKAIDMYLMGCFVFVF+ALLEYA VNYIFFGRGPQRQKK AEK A A N++ + + N+ Sbjct: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359 Query: 361 VDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGD 418 +D H NILL++LE+ NEM +E G+GD R++ +++D S IQYRK +PR GR + Sbjct: 360 MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALE 419 Query: 419 RSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473 R + KK+ LRRR+SQLKI IPDLTDVNAIDRWSRI FP FS FN+VYWLYYVN Sbjct: 420 RHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474 >gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 isoform 1 [Homo sapiens] Length = 512 Score = 754 bits (1947), Expect = 0.0 Identities = 379/513 (73%), Positives = 420/513 (81%), Gaps = 41/513 (7%) Query: 1 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60 MW + FGI+S P+++A VC AQSVNDP NMS VKETVD+LLKGYDIRLRPDFGGPP Sbjct: 1 MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP 59 Query: 61 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120 V VGMNIDIASIDMVSEVNMDYTLTMYFQQ WRDKRL+Y+ IPLNLTLDNRVADQLWVPD Sbjct: 60 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD 119 Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE Sbjct: 120 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 179 Query: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240 SYGYTTDDIEFYWRG D AVTGV +IELPQFSIV+++L+++ VVF+TG+YPRLSLSF+LK Sbjct: 180 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK 239 Query: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI Sbjct: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299 Query: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360 PYVKAIDMYLMGCFVFVF+ALLEYA VNYIFFGRGPQRQKK AEK A A N++ + + N+ Sbjct: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359 Query: 361 V--------------------------------------DAHGNILLTSLEVHNEM--NE 380 + D H NILL++LE+ NEM +E Sbjct: 360 IFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSE 419 Query: 381 VSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIP 440 G+GD R++ +++D S IQYRK +PR GR +R + KK+ LRRR+SQLKI IP Sbjct: 420 AVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIP 479 Query: 441 DLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473 DLTDVNAIDRWSRI FP FS FN+VYWLYYVN Sbjct: 480 DLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 512 >gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 precursor [Homo sapiens] Length = 474 Score = 745 bits (1923), Expect = 0.0 Identities = 367/477 (76%), Positives = 414/477 (86%), Gaps = 7/477 (1%) Query: 1 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60 MW + G+ S PV++ +VCCA S N+P NMS+VKETVD+LLKGYDIRLRPDFGGPP Sbjct: 1 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP 60 Query: 61 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120 V VGM ID+ASIDMVSEVNMDYTLTMYFQQ W+DKRL+YSGIPLNLTLDNRVADQLWVPD Sbjct: 61 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD 120 Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE Sbjct: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180 Query: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240 SYGYTTDDIEFYW GG+ AVTGV +IELPQFSIV++++VS+ V F TGAYPRLSLSFRLK Sbjct: 181 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240 Query: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300 RNIGYFILQTYMPS LITILSWVSFWINYDASAARVALGITTVLTMTTI+THLRETLPKI Sbjct: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300 Query: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360 PYVKAID+YLMGCFVFVFLALLEYAFVNYIFFG+GP QKK A K ++ N+++K E N+ Sbjct: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGP--QKKGASKQDQSANEKNKLEMNK 358 Query: 361 --VDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFL 416 VDAHGNILL++LE+ NE +EV + D + + S+D++ IQYRK RE +GR L Sbjct: 359 VQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRAL 418 Query: 417 GDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473 +P K +RRR+SQLK+KIPDLTDVN+ID+WSR+ FP TFSLFN+VYWLYYV+ Sbjct: 419 DRHGVP-SKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474 >gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor [Homo sapiens] Length = 632 Score = 368 bits (945), Expect = e-102 Identities = 162/309 (52%), Positives = 235/309 (76%) Query: 33 NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92 N + V++ +D++L YD+RLRP+FGG PV V ++I + SI+ +SE+NMDYT+TM+F Q W Sbjct: 55 NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114 Query: 93 RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152 +D RLAY LNLTLD R+ ++LWVPD YFLN K +FVH VTV+NR+ +LHPDGTV YG Sbjct: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174 Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFS 212 +R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI +W A+ E + +PQF+ Sbjct: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFT 234 Query: 213 IVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDAS 272 + + S+ V F TG+Y RL L F+++R + +++Q Y P++L TI SW+SFW+NYD+S Sbjct: 235 FLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSS 294 Query: 273 AARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFF 332 AARV +G+T++L +TTI++HLR+ LP I +KAID+Y++ C FVFL+LLEY ++NY+F+ Sbjct: 295 AARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFY 354 Query: 333 GRGPQRQKK 341 RGP+RQ + Sbjct: 355 SRGPRRQPR 363 Score = 44.3 bits (103), Expect = 2e-04 Identities = 15/28 (53%), Positives = 22/28 (78%) Query: 445 VNAIDRWSRIVFPFTFSLFNLVYWLYYV 472 V +D+WSR +FP F LFN+VYW+Y++ Sbjct: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHM 631 >gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta precursor [Homo sapiens] Length = 452 Score = 340 bits (872), Expect = 2e-93 Identities = 183/436 (41%), Positives = 272/436 (62%), Gaps = 34/436 (7%) Query: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100 +D L+ GY RP GGPPV V + +++ASID +SE NM+YT+T++ Q WRD RL+Y+ Sbjct: 44 LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103 Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160 L LD+R D+LW+PDT+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T A Sbjct: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163 Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220 C MDL +YP+DEQ C L++ESYGY+++DI +YW + + G+++++L QF+I +R + Sbjct: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223 Query: 221 RNVVF-ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALG 279 + F + G +PRLSL F L+RN G +I+Q+YMPS+L+ +SWVSFWI+ A ARV+LG Sbjct: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283 Query: 280 ITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQ 339 ITTVLTMTT+ R +LP+ +KA+D+Y C+VFVF AL+EYAF ++ R+ Sbjct: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF----NADYRK 339 Query: 340 KKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSG 399 K + AK K R ++E +D I+L SL G T+ AIS Sbjct: 340 K----QKAKVKVSRPRAE---MDVRNAIVLFSL----------SAAGVTQELAIS----- 377 Query: 400 IQYRKQSMPRE--GHGRFLGDRSLPHKKTHLRRRSSQ--LKIKIPDLTDVNAIDRWSRIV 455 R++ +P G R +G + KK R Q ++ ++ + D + ID ++R V Sbjct: 378 --RRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLRPI-DADTIDIYARAV 434 Query: 456 FPFTFSLFNLVYWLYY 471 FP F+ N++YW Y Sbjct: 435 FPAAFAAVNVIYWAAY 450 >gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo sapiens] Length = 479 Score = 330 bits (847), Expect = 1e-90 Identities = 176/423 (41%), Positives = 268/423 (63%), Gaps = 33/423 (7%) Query: 48 YDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY-SGIPLNL 106 +D +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y + YW+D+RL++ S L++ Sbjct: 84 HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143 Query: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166 T D R+ ++WVPD +F++ K+SF+H T N M+R+ PDG VLY LR+T TA C MD Sbjct: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203 Query: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF- 225 R+PLD Q C+LEIESY YT DD+ YW+ G+ ++ ERI L QF I E ++ + Sbjct: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263 Query: 226 ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285 +TG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+ A ARV LGITTVLT Sbjct: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323 Query: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345 M+TI T + ++P++ Y+KA+D+YL FVFVFL++LEYA VNY+ + ++++KL EK Sbjct: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ-ERKEQKLREK 382 Query: 346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ 405 ++ + +L E+N++ + + D +Q Sbjct: 383 LPC---------TSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP---DRMMVQLTLA 430 Query: 406 SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNL 465 S +RS P +K+ +RSS + ++I D +AID++SRI+FP + LFNL Sbjct: 431 S-----------ERSSPQRKS---QRSSYVSMRI----DTHAIDKYSRIIFPAAYILFNL 472 Query: 466 VYW 468 +YW Sbjct: 473 IYW 475 >gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 precursor [Homo sapiens] Length = 490 Score = 324 bits (831), Expect = 9e-89 Identities = 172/434 (39%), Positives = 262/434 (60%), Gaps = 49/434 (11%) Query: 48 YDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIP-LNL 106 +D +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y + YW+D+RLA+S ++ Sbjct: 89 HDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSM 148 Query: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166 T D R+ ++WVPD +F++ K+SF H T N M+R+ PDG VLY +RIT TA C MD Sbjct: 149 TFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFS 208 Query: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFA 226 +PLD Q C+LE+ESY YT +D+ YW+ GD+++ E+I L QF I + SR ++ Sbjct: 209 HFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYS 268 Query: 227 -TGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285 TG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+ A ARV+LGITTVLT Sbjct: 269 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLT 328 Query: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAE- 344 MTTI T + ++P++ YVKA+D+YL FVFVFL++LEYA VNY+ + ++++KL E Sbjct: 329 MTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ-ERKERKLREK 387 Query: 345 ----------KTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAIS 394 KT S+SE+N + + + + E + V G+ N+A Sbjct: 388 FPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAA-- 445 Query: 395 FDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRI 454 +K L + + +I + +AID++SR+ Sbjct: 446 -----------------------------RKKGLLKGQTGFRI----FQNTHAIDKYSRL 472 Query: 455 VFPFTFSLFNLVYW 468 +FP ++ FNL+YW Sbjct: 473 IFPASYIFFNLIYW 486 >gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo sapiens] Length = 467 Score = 314 bits (804), Expect = 1e-85 Identities = 173/428 (40%), Positives = 259/428 (60%), Gaps = 35/428 (8%) Query: 49 DIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY-SGIPLNLT 107 D +RP FGG PV VG+++ + SID +SE NMD+T+T Y + YW+D+RL++ S ++T Sbjct: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130 Query: 108 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 167 D+R+ ++WVPD +F++ K+SF+H T++N M+R+HPDG VL LRIT +A C MD R Sbjct: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190 Query: 168 YPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF-- 225 +PLD QNC+LE+ESY Y DD+ YW+ G+K++ E + L QF +E S + F Sbjct: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQF-FIEDFSASSGLAFYS 249 Query: 226 ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285 +TG Y RL ++F L+R++ +F+LQTY P+IL+ +LSWVSFWI+ A ARV+LGITTVLT Sbjct: 250 STGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLT 309 Query: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345 M+TI T + ++P++ Y+KA+D+YL +FVFL+++EYA VNY+ ++K +K Sbjct: 310 MSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL----TTVEERKQFKK 365 Query: 346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ 405 T K S +DA + +E+ D +++S ++ RK Sbjct: 366 TGKI------SRMYNIDAVQAMAFDGCYHDSEI--------DMDQTSLSLNSEDFMRRKS 411 Query: 406 -SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFN 464 P R RR+S + L + + ID +SRI+FP + LFN Sbjct: 412 ICSPSTDSSRI------------KRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFN 459 Query: 465 LVYWLYYV 472 L YW YV Sbjct: 460 LFYWGVYV 467 >gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo sapiens] Length = 440 Score = 314 bits (804), Expect = 1e-85 Identities = 174/432 (40%), Positives = 252/432 (58%), Gaps = 36/432 (8%) Query: 42 DKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSG 101 + L GY+ LRP+FGG PV + + +DIASI +SE NMDYT T+Y +Q W D+RL + G Sbjct: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101 Query: 102 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 161 + TLD R+ + LWVPDTY + KKSF+H VTV NR+IRL +GTVLY LRITTT AC Sbjct: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160 Query: 162 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSR 221 MDL +YP+D Q C L++ES+GY +D+EF W G+ +V G+E + L Q++I + + Sbjct: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220 Query: 222 NVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT 281 TG Y RL L F L+RN+ YFIL+TY+PS + +LSWVSFWI+ D+ AR +G+T Sbjct: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280 Query: 282 TVLTMTTINTHLRETLPKIP-YVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340 TVL+MTT+ R +LP ++KAID+YL CF FVF ALLEYA +Y Sbjct: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY----------S 330 Query: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGI 400 L + AK DR ++ + NI+ +S+ ++I + + Sbjct: 331 SLQQMAAK---DRGTTKEVEEVSITNIINSSISSFKRKISF---------ASIEISSDNV 378 Query: 401 QYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTF 460 Y +M +F+ R + ++ + + + + +D +S+++FP F Sbjct: 379 DYSDLTMKTSDKFKFV-----------FREKMGRI-VDYFTIQNPSNVDHYSKLLFPLIF 426 Query: 461 SLFNLVYWLYYV 472 L N+ YW YY+ Sbjct: 427 MLANVFYWAYYM 438 >gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] Length = 464 Score = 293 bits (750), Expect = 2e-79 Identities = 169/436 (38%), Positives = 252/436 (57%), Gaps = 36/436 (8%) Query: 41 VDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL 97 +DKL+ GYD R+RP+F GPPV V NI I S ++E MDY + ++ +Q W D RL Sbjct: 47 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRL 106 Query: 98 AYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156 AYS P + L LD + D +W PD +F N+K + H VT N+++R+ +G VLY +R+T Sbjct: 107 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 166 Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216 T +C MDL+ +P+D Q C +++ES+GYT +D+ F W+ + V E + LPQF + E Sbjct: 167 LTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQD-EAPVQVAEGLTLPQFLLKEE 225 Query: 217 R-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAAR 275 + L + TG + + + F L+R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ AR Sbjct: 226 KDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 285 Query: 276 VALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRG 335 VALGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FVF ALLEYA VN++ Sbjct: 286 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFV----- 340 Query: 336 PQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISF 395 ++ K+L K KN K+E+ +LE +++ + ++R S ++ Sbjct: 341 SRQHKELLRFRRKRKN---KTEA-----------FALEKFYRFSDMDDEVRESRFSFTAY 386 Query: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455 K M +G P+ + +S K+ + ID SR Sbjct: 387 GMGPCLQAKDGMTPKG----------PNHPVQVMPKSPDEMRKV-FIDRAKKIDTISRAC 435 Query: 456 FPFTFSLFNLVYWLYY 471 FP F +FN+ YW+ Y Sbjct: 436 FPLAFLIFNIFYWVIY 451 >gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] Length = 452 Score = 291 bits (744), Expect = 1e-78 Identities = 173/453 (38%), Positives = 250/453 (55%), Gaps = 49/453 (10%) Query: 25 AQSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMD 81 ++S P + +DKL+ GYD R+RP+F GPPV V NI I S V+E MD Sbjct: 32 SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMD 91 Query: 82 YTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 140 Y + ++ +Q W D RLAYS P + L LD + D +W PD +F N+K + H VT N++ Sbjct: 92 YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151 Query: 141 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAV 200 +R+ +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W D V Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGPV 210 Query: 201 TGVERIELPQFSIVEHRLVSRNVV-FATGAYPRLSLSFRLKRNIGYFILQTYMPSILITI 259 E + LPQF + E + + + TG + + + F L+R +GY+++Q Y+PS+LI I Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVI 270 Query: 260 LSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFL 319 LSWVSFWIN DA+ ARVALGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FVF Sbjct: 271 LSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFA 330 Query: 320 ALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMN 379 ALLEYA VN++ RQ K + + + ++K E Sbjct: 331 ALLEYAAVNFV------SRQHKEFLRLRRRQKRQNKEED--------------------- 363 Query: 380 EVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHG-RFLGDRSLPHKKTHLRRRSSQLKIK 438 TR S +F G+ + Q ++G + LP + +K K Sbjct: 364 -------VTRESRFNFSGYGMGHCLQ--VKDGTAVKATPANPLPQPP----KDGDAIKKK 410 Query: 439 IPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471 D ID SR FP F +FN+ YW+ Y Sbjct: 411 FVD--RAKRIDTISRAAFPLAFLIFNIFYWITY 441 >gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] Length = 452 Score = 291 bits (744), Expect = 1e-78 Identities = 173/453 (38%), Positives = 250/453 (55%), Gaps = 49/453 (10%) Query: 25 AQSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMD 81 ++S P + +DKL+ GYD R+RP+F GPPV V NI I S V+E MD Sbjct: 32 SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMD 91 Query: 82 YTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 140 Y + ++ +Q W D RLAYS P + L LD + D +W PD +F N+K + H VT N++ Sbjct: 92 YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151 Query: 141 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAV 200 +R+ +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W D V Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGPV 210 Query: 201 TGVERIELPQFSIVEHRLVSRNVV-FATGAYPRLSLSFRLKRNIGYFILQTYMPSILITI 259 E + LPQF + E + + + TG + + + F L+R +GY+++Q Y+PS+LI I Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVI 270 Query: 260 LSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFL 319 LSWVSFWIN DA+ ARVALGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FVF Sbjct: 271 LSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFA 330 Query: 320 ALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMN 379 ALLEYA VN++ RQ K + + + ++K E Sbjct: 331 ALLEYAAVNFV------SRQHKEFLRLRRRQKRQNKEED--------------------- 363 Query: 380 EVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHG-RFLGDRSLPHKKTHLRRRSSQLKIK 438 TR S +F G+ + Q ++G + LP + +K K Sbjct: 364 -------VTRESRFNFSGYGMGHCLQ--VKDGTAVKATPANPLPQPP----KDGDAIKKK 410 Query: 439 IPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471 D ID SR FP F +FN+ YW+ Y Sbjct: 411 FVD--RAKRIDTISRAAFPLAFLIFNIFYWITY 441 >gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] Length = 452 Score = 290 bits (743), Expect = 1e-78 Identities = 172/453 (37%), Positives = 250/453 (55%), Gaps = 49/453 (10%) Query: 25 AQSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMD 81 ++S P + +DKL+ GYD R+RP+F GPPV V NI I S ++E MD Sbjct: 32 SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMD 91 Query: 82 YTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 140 Y + ++ +Q W D RLAYS P + L LD + D +W PD +F N+K + H VT N++ Sbjct: 92 YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151 Query: 141 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAV 200 +R+ +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W D V Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGPV 210 Query: 201 TGVERIELPQFSIVEHRLVSRNVV-FATGAYPRLSLSFRLKRNIGYFILQTYMPSILITI 259 E + LPQF + E + + + TG + + + F L+R +GY+++Q Y+PS+LI I Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVI 270 Query: 260 LSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFL 319 LSWVSFWIN DA+ ARVALGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FVF Sbjct: 271 LSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFA 330 Query: 320 ALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMN 379 ALLEYA VN++ RQ K + + + ++K E Sbjct: 331 ALLEYAAVNFV------SRQHKEFLRLRRRQKRQNKEED--------------------- 363 Query: 380 EVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHG-RFLGDRSLPHKKTHLRRRSSQLKIK 438 TR S +F G+ + Q ++G + LP + +K K Sbjct: 364 -------VTRESRFNFSGYGMGHCLQ--VKDGTAVKATPANPLPQPP----KDGDAIKKK 410 Query: 439 IPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471 D ID SR FP F +FN+ YW+ Y Sbjct: 411 FVD--RAKRIDTISRAAFPLAFLIFNIFYWITY 441 >gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo sapiens] Length = 457 Score = 288 bits (736), Expect = 1e-77 Identities = 167/437 (38%), Positives = 245/437 (56%), Gaps = 38/437 (8%) Query: 41 VDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL 97 +DKL+ GYD R+RP+F GPPV V NI I S ++E MDY + ++ +Q W D RL Sbjct: 42 LDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRL 101 Query: 98 AYSGIP-LNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156 AY+ P +L LD + D +W PD +F N+K + H +T N+++R+ +G VLY +RIT Sbjct: 102 AYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRIT 161 Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216 T AC MDL+ +P+D Q C +++ES+GYT +D+ F W+ AV + + LPQF + E Sbjct: 162 LTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQ-EQGAVQVADGLTLPQFILKEE 220 Query: 217 R-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAAR 275 + L + TG + + F L+R +GY+++Q Y+PS+LI ILSW+SFWIN DA+ AR Sbjct: 221 KDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPAR 280 Query: 276 VALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRG 335 V LGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FVF ALLEYA VN++ Sbjct: 281 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFV----- 335 Query: 336 PQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISF 395 ++ K+L K ++ +S + N E G G SA Sbjct: 336 SRQHKELLRFRRKRRHHKS------------------PMLNLFQEDEAGEGRFNFSAYGM 377 Query: 396 DNSGIQYRKQ-SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRI 454 + +Q + S+ + P K R+ + K ID+ SRI Sbjct: 378 GPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAK--------KIDKISRI 429 Query: 455 VFPFTFSLFNLVYWLYY 471 FP F +FN+ YW+ Y Sbjct: 430 GFPMAFLIFNMFYWIIY 446 >gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1 precursor [Homo sapiens] Length = 475 Score = 286 bits (733), Expect = 2e-77 Identities = 158/437 (36%), Positives = 238/437 (54%), Gaps = 38/437 (8%) Query: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100 ++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL ++ Sbjct: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129 Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160 L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189 Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220 C + L +P+DE +C LE SYGY ++I + W+ V L QFS V R + Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249 Query: 221 RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280 V +G Y +S+ F L R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGI Sbjct: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309 Query: 281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340 TTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y R P + K Sbjct: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369 Query: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI-----GDTRNSAISF 395 +K + K+ + + + + H + + G D + F Sbjct: 370 DKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCF 429 Query: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455 ++ R G R H + H+R + +D ++RI Sbjct: 430 EDC----------RTGAWR--------HGRIHIR---------------IAKMDSYARIF 456 Query: 456 FPFTFSLFNLVYWLYYV 472 FP F LFNLVYW+ Y+ Sbjct: 457 FPTAFCLFNLVYWVSYL 473 >gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] Length = 449 Score = 286 bits (733), Expect = 2e-77 Identities = 165/436 (37%), Positives = 243/436 (55%), Gaps = 51/436 (11%) Query: 41 VDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL 97 +DKL+ GYD R+RP+F GPPV V NI I S ++E MDY + ++ +Q W D RL Sbjct: 47 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRL 106 Query: 98 AYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156 AYS P + L LD + D +W PD +F N+K + H VT N+++R+ +G VLY +R+T Sbjct: 107 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 166 Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216 T +C MDL+ +P+D Q C +++ES+GYT +D+ F W+ + V E + LPQF + E Sbjct: 167 LTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQD-EAPVQVAEGLTLPQFLLKEE 225 Query: 217 R-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAAR 275 + L + TG + + + F L+R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ AR Sbjct: 226 KDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 285 Query: 276 VALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRG 335 VALGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FVF ALLEYA VN++ Sbjct: 286 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFV----- 340 Query: 336 PQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISF 395 ++ K+L K KN + +R + + G+G + Sbjct: 341 SRQHKELLRFRRKRKNKDDEVRESR-----------------FSFTAYGMGPCLQAKDGM 383 Query: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455 G + Q MP+ S +++ + ID SR Sbjct: 384 TPKGPNHPVQVMPK-----------------------SPDEMRKVFIDRAKKIDTISRAC 420 Query: 456 FPFTFSLFNLVYWLYY 471 FP F +FN+ YW+ Y Sbjct: 421 FPLAFLIFNIFYWVIY 436 >gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2 precursor [Homo sapiens] Length = 467 Score = 285 bits (730), Expect = 5e-77 Identities = 160/433 (36%), Positives = 240/433 (55%), Gaps = 38/433 (8%) Query: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100 ++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL ++ Sbjct: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129 Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160 L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189 Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220 C + L +P+DE +C LE SYGY ++I + W+ V L QFS V R + Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249 Query: 221 RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280 V +G Y +S+ F L R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGI Sbjct: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309 Query: 281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340 TTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y R P + K Sbjct: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369 Query: 341 KLAEKTAKAKND-RSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSG 399 +K D R +S + +++ ++ E E + D + F++ Sbjct: 370 DKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK----DCASFFCCFEDC- 424 Query: 400 IQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFT 459 R G R H + H+R + +D ++RI FP Sbjct: 425 ---------RTGAWR--------HGRIHIR---------------IAKMDSYARIFFPTA 452 Query: 460 FSLFNLVYWLYYV 472 F LFNLVYW+ Y+ Sbjct: 453 FCLFNLVYWVSYL 465 >gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo sapiens] Length = 449 Score = 285 bits (730), Expect = 5e-77 Identities = 164/436 (37%), Positives = 241/436 (55%), Gaps = 44/436 (10%) Query: 41 VDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL 97 +DKL+ GYD R+RP+F GPPV V NI I S ++E MDY + ++ +Q W D RL Sbjct: 42 LDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRL 101 Query: 98 AYSGIP-LNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156 AY+ P +L LD + D +W PD +F N+K + H +T N+++R+ +G VLY +RIT Sbjct: 102 AYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRIT 161 Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216 T AC MDL+ +P+D Q C +++ES+GYT +D+ F W+ AV + + LPQF + E Sbjct: 162 LTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQ-EQGAVQVADGLTLPQFILKEE 220 Query: 217 R-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAAR 275 + L + TG + + F L+R +GY+++Q Y+PS+LI ILSW+SFWIN DA+ AR Sbjct: 221 KDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPAR 280 Query: 276 VALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRG 335 V LGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FVF ALLEYA VN++ R Sbjct: 281 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFV--SRQ 338 Query: 336 PQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISF 395 + + K K D + A+G + L+ + ++ +T N + Sbjct: 339 HKELLRFRRKRRHHKEDEAGEGRFNFSAYG-MGPACLQAKDGISVKGANNSNTTNPPPAP 397 Query: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455 S + RK + R ID+ SRI Sbjct: 398 SKSPEEMRKLFIQR-----------------------------------AKKIDKISRIG 422 Query: 456 FPFTFSLFNLVYWLYY 471 FP F +FN+ YW+ Y Sbjct: 423 FPMAFLIFNMFYWIIY 438 >gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor [Homo sapiens] Length = 465 Score = 279 bits (713), Expect = 5e-75 Identities = 161/436 (36%), Positives = 237/436 (54%), Gaps = 36/436 (8%) Query: 37 VKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKR 96 + + ++ LL+GYD +LRPD G P + ++ + SI V +NM+YT+ + F Q W D R Sbjct: 64 ITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSR 123 Query: 97 LAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156 L ++ L L++ + ++W+PDT+F N +KS H +T NR++R+ DG VLY LR+T Sbjct: 124 LKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLT 183 Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216 A C + L +P+DE +C LE SYGY ++IE+ W+ V + L QF+ V Sbjct: 184 INAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGL 243 Query: 217 RLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARV 276 R + +G Y +++ F L R +GYF +QTY+P IL +LSWVSFWIN DA AR Sbjct: 244 RNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPART 303 Query: 277 ALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGP 336 +LGITTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y Sbjct: 304 SLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYF----TS 359 Query: 337 QRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFD 396 ++ K A K K KN S + G+ L+ + + G SF Sbjct: 360 NQKGKTATKDRKLKNKASMTPGLH---PGSTLIPMNNISVPQEDDYGYQCLEGKDCASFF 416 Query: 397 NSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVF 456 R S REG + H+R + ID +SRI F Sbjct: 417 CCFEDCRTGSW-REG-------------RIHIR---------------IAKIDSYSRIFF 447 Query: 457 PFTFSLFNLVYWLYYV 472 P F+LFNLVYW+ Y+ Sbjct: 448 PTAFALFNLVYWVGYL 463 >gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 precursor [Homo sapiens] Length = 462 Score = 278 bits (711), Expect = 8e-75 Identities = 158/447 (35%), Positives = 239/447 (53%), Gaps = 47/447 (10%) Query: 33 NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92 N++ +D LL GYD RLRP G V +I + S VS+ M+YT+ ++F+Q W Sbjct: 45 NITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSW 104 Query: 93 RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152 +D+RL + G L L+N +A ++W PDT+F N KKS H +T N+++RL DGT+LY Sbjct: 105 KDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYT 164 Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGD--KAVTGVERIELPQ 210 +R+T +A C M L +P+D C L+ SY Y ++ + W G V + L Q Sbjct: 165 MRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQ 224 Query: 211 FSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYD 270 + ++ + + N+ +TG Y ++ F LKR IGYF++QTY+P I+ ILS VSFW+N + Sbjct: 225 YHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 284 Query: 271 ASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYI 330 + AR G+TTVLTMTT++ R +LPK+ Y A+D ++ C+ FVF AL+E+A VNY Sbjct: 285 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY- 343 Query: 331 FFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMN----EVSGGIG 386 F RG K A + AK K R + +A T+ ++ + N + G Sbjct: 344 FTKRGWAWDGKKALEAAKIKKKREVILNKSTNA-----FTTGKMSHPPNIPKEQTPAGTS 398 Query: 387 DTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVN 446 +T + ++ P E +++ KKT+ ++ Sbjct: 399 NTTSVSVK-------------PSE-------EKTSESKKTY---------------NSIS 423 Query: 447 AIDRWSRIVFPFTFSLFNLVYWLYYVN 473 ID+ SRIVFP F FNLVYW Y+N Sbjct: 424 KIDKMSRIVFPVLFGTFNLVYWATYLN 450 >gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo sapiens] Length = 451 Score = 276 bits (707), Expect = 2e-74 Identities = 163/444 (36%), Positives = 242/444 (54%), Gaps = 42/444 (9%) Query: 33 NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92 N++ +D+LL GYD RLRP G V NI + S VS+ +M+YT+ ++F+Q W Sbjct: 38 NITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKW 97 Query: 93 RDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 151 +D+RL + G P+N L L+N +A ++W PDT+F N KKS H +T+ N+++R+ DGT+LY Sbjct: 98 KDERLKFKG-PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLY 156 Query: 152 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW--RGGDKAVTGVERIELP 209 +R+T A C M L +P+D +C L+ SY YTT ++ + W D + L Sbjct: 157 TMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLN 216 Query: 210 QFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINY 269 Q+ ++ + + +TG Y ++ F LKR IGYF++QTY+P I+ ILS VSFW+N Sbjct: 217 QYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNR 276 Query: 270 DASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY 329 ++ AR G+TTVLTMTT++ R +LPK+ Y A+D ++ C+ FVF AL+E+A VNY Sbjct: 277 ESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY 336 Query: 330 IFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTR 389 F RG A ND+ K +++ V N ++ V N +S D Sbjct: 337 -FTKRG------WAWDGKSVVNDKKKEKAS-VMIQNNAY--AVAVANYAPNLS---KDPV 383 Query: 390 NSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAID 449 S IS + + P P+KK + ++ V+ ID Sbjct: 384 LSTIS--------KSATTPE------------PNKKPENKPAEAK-----KTFNSVSKID 418 Query: 450 RWSRIVFPFTFSLFNLVYWLYYVN 473 R SRIVFP F FNLVYW Y+N Sbjct: 419 RMSRIVFPVLFGTFNLVYWATYLN 442 >gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor [Homo sapiens] Length = 451 Score = 276 bits (707), Expect = 2e-74 Identities = 163/444 (36%), Positives = 242/444 (54%), Gaps = 42/444 (9%) Query: 33 NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92 N++ +D+LL GYD RLRP G V NI + S VS+ +M+YT+ ++F+Q W Sbjct: 38 NITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKW 97 Query: 93 RDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 151 +D+RL + G P+N L L+N +A ++W PDT+F N KKS H +T+ N+++R+ DGT+LY Sbjct: 98 KDERLKFKG-PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLY 156 Query: 152 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW--RGGDKAVTGVERIELP 209 +R+T A C M L +P+D +C L+ SY YTT ++ + W D + L Sbjct: 157 TMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLN 216 Query: 210 QFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINY 269 Q+ ++ + + +TG Y ++ F LKR IGYF++QTY+P I+ ILS VSFW+N Sbjct: 217 QYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNR 276 Query: 270 DASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY 329 ++ AR G+TTVLTMTT++ R +LPK+ Y A+D ++ C+ FVF AL+E+A VNY Sbjct: 277 ESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY 336 Query: 330 IFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTR 389 F RG A ND+ K +++ V N ++ V N +S D Sbjct: 337 -FTKRG------WAWDGKSVVNDKKKEKAS-VMIQNNAY--AVAVANYAPNLS---KDPV 383 Query: 390 NSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAID 449 S IS + + P P+KK + ++ V+ ID Sbjct: 384 LSTIS--------KSATTPE------------PNKKPENKPAEAK-----KTFNSVSKID 418 Query: 450 RWSRIVFPFTFSLFNLVYWLYYVN 473 R SRIVFP F FNLVYW Y+N Sbjct: 419 RMSRIVFPVLFGTFNLVYWATYLN 442 >gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor [Homo sapiens] Length = 492 Score = 276 bits (707), Expect = 2e-74 Identities = 159/446 (35%), Positives = 239/446 (53%), Gaps = 33/446 (7%) Query: 33 NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92 N++ +D+LL GYD RLRP G V +I + S VS+ +M+YT+ ++F+Q W Sbjct: 63 NITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTW 122 Query: 93 RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152 D+RL + G L L+N +A ++W PDT+F N KKS H +T N+++RL +GT+LY Sbjct: 123 HDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYT 182 Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWR-GGDKAV-TGVERIELPQ 210 +R+T A C M L +P+D C L+ SY YTT ++ + W G +K+V + L Q Sbjct: 183 MRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQ 242 Query: 211 FSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYD 270 + ++ H + + + +TG Y ++ F LKR IGYF++QTY+P I+ ILS VSFW+N + Sbjct: 243 YDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 302 Query: 271 ASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYI 330 + AR G+TTVLTMTT++ R +LPK+ Y A+D ++ C+ FVF AL+E+A VNY Sbjct: 303 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF 362 Query: 331 FFGRGPQRQKKLAEKTAKAKND---RSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGD 387 KK+ E K +K S + G +L E + +S G Sbjct: 363 TKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAP 422 Query: 388 TRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNA 447 + +S + S Q P E KT+ V+ Sbjct: 423 SASSTPTIIASPKATYVQDSPTE-------------TKTY---------------NSVSK 454 Query: 448 IDRWSRIVFPFTFSLFNLVYWLYYVN 473 +D+ SRI+FP F++FNLVYW YVN Sbjct: 455 VDKISRIIFPVLFAIFNLVYWATYVN 480 >gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens] Length = 417 Score = 275 bits (703), Expect = 7e-74 Identities = 135/295 (45%), Positives = 197/295 (66%), Gaps = 5/295 (1%) Query: 41 VDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL 97 +DKL+ GYD R+RP+F GPPV V NI I S +++ MDY + ++ +Q W D RL Sbjct: 48 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRL 107 Query: 98 AYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156 +Y P + L LD + D +W PD +F N+K + H VT N+++R+ +G VLY +R+T Sbjct: 108 SYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 167 Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216 +C+MDL+ +P+D Q CT+++ES+GYT D+ F W AV E + LPQF + + Sbjct: 168 LILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDE 227 Query: 217 R-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAAR 275 + L + TG + + + F L+R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ AR Sbjct: 228 KDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 287 Query: 276 VALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYI 330 V LGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FVF ALLEYA +N++ Sbjct: 288 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFV 342 >gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 [Homo sapiens] Length = 467 Score = 271 bits (692), Expect = 1e-72 Identities = 153/432 (35%), Positives = 237/432 (54%), Gaps = 17/432 (3%) Query: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100 ++KLL+ YD +LRPD G P + ++I + SI VS +NM+Y + ++F Q W D RL ++ Sbjct: 51 LNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFN 110 Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160 LTL++ + +W+PDT F N K + H +T N+++R+ DG +LY LR+T A Sbjct: 111 STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170 Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220 C + L +P+DE +C L SYGY +++ + WR + L QF + R + Sbjct: 171 CQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTT 230 Query: 221 RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280 V + G Y +++ F L R +GYF +QTY+P IL +LSWVSFWI DA+ AR ALGI Sbjct: 231 EIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGI 290 Query: 281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340 TTVLTMTT++T R++LP++ YV A+D+++ CF+FVF AL+EYA +NY R P K Sbjct: 291 TTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTK 350 Query: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGI 400 K T+ D S+ R+ + L++ + T N+++ + Sbjct: 351 K---TTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMI-----TLNNSVYWQEFED 402 Query: 401 QYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTF 460 + + + F + R ++ I I +L D +SR+ FP +F Sbjct: 403 TCVYECLDGKDCQSFF---CCYEECKSGSWRKGRIHIDILEL------DSYSRVFFPTSF 453 Query: 461 SLFNLVYWLYYV 472 LFNLVYW+ Y+ Sbjct: 454 LLFNLVYWVGYL 465 >gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor [Homo sapiens] Length = 554 Score = 268 bits (684), Expect = 1e-71 Identities = 167/493 (33%), Positives = 256/493 (51%), Gaps = 61/493 (12%) Query: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100 +D LL GYD RLRP FGGP V +I + S VS+V M+YT+ ++F+Q W DKRL Y Sbjct: 52 LDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111 Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160 G L L+N + ++W PDT+F N KKS H +T N++ R+ +GT+LY +R+T +A Sbjct: 112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAE 171 Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW-RGGDKAV-TGVERIELPQFSIVEHRL 218 C M L +P+D C L+ SY Y ++ + W +G +K+V E L Q+ ++ + Sbjct: 172 CPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTV 231 Query: 219 VSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVAL 278 S + TG Y +++ F L+R +GYF++QTY+P I+ ILS VSFWIN ++ AR Sbjct: 232 SSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVF 291 Query: 279 GITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY---IFFGRG 335 GITTVLTMTT++ R +LPK+ Y A+D ++ CF FVF AL+E+A VNY I + Sbjct: 292 GITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKA 351 Query: 336 PQRQKKLAEKTAKAKNDRSK-SESNRVDAHGNILL---TSLEVHNEM---NEVSGGIGDT 388 ++ K ++ A R K E+ + + N+ + T+ VH+E N G + Sbjct: 352 KRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSS 411 Query: 389 RNSAISFDNS----------------------------------------GIQYRKQSMP 408 ++S + ++S G RK S+ Sbjct: 412 KSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVG 471 Query: 409 REGHGRFLGDRSLPHKKTHLRRRSSQLKIKI--------PDLTDVNAIDRWSRIVFPFTF 460 G R L KT + + K+ P + + ID+++RI+FP TF Sbjct: 472 SASTRHVFGSR-LQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTF 530 Query: 461 SLFNLVYWLYYVN 473 FN+VYW+ Y++ Sbjct: 531 GAFNMVYWVVYLS 543 >gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3 precursor [Homo sapiens] Length = 515 Score = 265 bits (677), Expect = 7e-71 Identities = 157/477 (32%), Positives = 238/477 (49%), Gaps = 78/477 (16%) Query: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100 ++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL ++ Sbjct: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129 Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160 L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189 Query: 161 CMMDLRRYPLDEQNCTLEIESY-------------------------------------- 182 C + L +P+DE +C LE S+ Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249 Query: 183 --GYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240 GY ++I + W+ V L QFS V R + V +G Y +S+ F L Sbjct: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 309 Query: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300 R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGITTVLTMTT++T R++LPK+ Sbjct: 310 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKV 369 Query: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360 YV A+D+++ CF+FVF AL+EY ++Y R P + K +K + K+ + Sbjct: 370 SYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTID 429 Query: 361 VDAHGNILLTSLEVHNEMNEVSGGI-----GDTRNSAISFDNSGIQYRKQSMPREGHGRF 415 + + + H + + G D + F++ R G R Sbjct: 430 IRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDC----------RTGAWR- 478 Query: 416 LGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472 H + H+R + +D ++RI FP F LFNLVYW+ Y+ Sbjct: 479 -------HGRIHIR---------------IAKMDSYARIFFPTAFCLFNLVYWVSYL 513 >gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 precursor [Homo sapiens] Length = 456 Score = 265 bits (677), Expect = 7e-71 Identities = 158/445 (35%), Positives = 232/445 (52%), Gaps = 42/445 (9%) Query: 33 NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92 N + +D+LL GYD RLRP G V +I + S VS+ +M+YT+ ++F+Q W Sbjct: 38 NTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSW 97 Query: 93 RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152 +D+RL + G L L+N +A ++W PDT+F N KKS H +T+ N+++R+ DGT+LY Sbjct: 98 KDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYT 157 Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW--RGGDKAVTGVERIELPQ 210 +R+T A C M L +P+D C L+ SY YT ++ + W V + L Q Sbjct: 158 MRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQ 217 Query: 211 FSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYD 270 + ++ + S V +TG Y ++ F LKR IGYF++QTY+P I+ ILS VSFW+N + Sbjct: 218 YDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 277 Query: 271 ASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYI 330 + AR G+TTVLTMTT++ R +LPK+ Y A+D ++ C+ FVF AL+E+A VNY Sbjct: 278 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY- 336 Query: 331 FFGRGPQRQKK--LAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDT 388 F RG K + EK K K+ K + T+ + G+ Sbjct: 337 FTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP-------TATSYTPNLARGDPGLATI 389 Query: 389 RNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAI 448 SA + + ++ P E KKT V+ I Sbjct: 390 AKSATIEPK---EVKPETKPPE------------PKKT---------------FNSVSKI 419 Query: 449 DRWSRIVFPFTFSLFNLVYWLYYVN 473 DR SRI FP F +FNLVYW Y+N Sbjct: 420 DRLSRIAFPLLFGIFNLVYWATYLN 444 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.324 0.140 0.428 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,422,155 Number of Sequences: 37866 Number of extensions: 660862 Number of successful extensions: 2039 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 63 Number of HSP's successfully gapped in prelim test: 9 Number of HSP's that attempted gapping in prelim test: 1856 Number of HSP's gapped (non-prelim): 117 length of query: 473 length of database: 18,247,518 effective HSP length: 106 effective length of query: 367 effective length of database: 14,233,722 effective search space: 5223775974 effective search space used: 5223775974 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.