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Search of human proteins with 4503843
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503843 adaptor-related protein complex 1, gamma 2 subunit
[Homo sapiens]
(785 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H... 1543 0.0
gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i... 941 0.0
gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i... 936 0.0
gi|19913414 adaptor-related protein complex 2, alpha 1 subunit i... 262 1e-69
gi|19913416 adaptor-related protein complex 2, alpha 1 subunit i... 260 4e-69
gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [... 253 5e-67
gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit... 216 9e-56
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 144 2e-34
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 89 2e-17
gi|14719400 ADP-ribosylation factor binding protein 3 isoform sh... 72 2e-12
gi|20336267 ADP-ribosylation factor binding protein 3 isoform lo... 72 2e-12
gi|9558751 ADP-ribosylation factor binding protein 2 [Homo sapiens] 69 2e-11
gi|9558729 golgi associated, gamma adaptin ear containing, ARF b... 66 1e-10
gi|48527952 golgi associated, gamma adaptin ear containing, ARF ... 66 1e-10
gi|239758145 PREDICTED: similar to ADP-ribosylation factor bindi... 64 4e-10
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso... 58 4e-08
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso... 58 4e-08
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H... 56 1e-07
gi|71773106 adaptor-related protein complex 2, beta 1 subunit is... 54 4e-07
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso... 54 4e-07
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [... 51 4e-06
gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi... 50 8e-06
gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi... 50 8e-06
gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens] 50 8e-06
gi|11559929 coatomer protein complex, subunit gamma 1 [Homo sapi... 48 3e-05
gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sap... 47 9e-05
gi|47132519 Ras association and pleckstrin homology domains 1 is... 37 0.071
gi|54144631 phosphatase and actin regulator 1 [Homo sapiens] 36 0.12
gi|88900505 tyrosine hydroxylase isoform c [Homo sapiens] 35 0.21
gi|88900501 tyrosine hydroxylase isoform a [Homo sapiens] 35 0.21
>gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo
sapiens]
Length = 785
Score = 1543 bits (3994), Expect = 0.0
Identities = 785/785 (100%), Positives = 785/785 (100%)
Query: 1 MVVPSLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHML 60
MVVPSLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHML
Sbjct: 1 MVVPSLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHML 60
Query: 61 GYPAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQ 120
GYPAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQ
Sbjct: 61 GYPAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQ 120
Query: 121 GLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPC 180
GLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPC
Sbjct: 121 GLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPC 180
Query: 181 AQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISG 240
AQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISG
Sbjct: 181 AQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISG 240
Query: 241 VSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDI 300
VSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDI
Sbjct: 241 VSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDI 300
Query: 301 RSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDA 360
RSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDA
Sbjct: 301 RSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDA 360
Query: 361 SLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHI 420
SLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHI
Sbjct: 361 SLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHI 420
Query: 421 DTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWC 480
DTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWC
Sbjct: 421 DTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWC 480
Query: 481 IGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCG 540
IGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCG
Sbjct: 481 IGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCG 540
Query: 541 DNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAILEKMPLVERDGPQADEEAK 600
DNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAILEKMPLVERDGPQADEEAK
Sbjct: 541 DNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAILEKMPLVERDGPQADEEAK 600
Query: 601 ESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGALVHLLDLPCV 660
ESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGALVHLLDLPCV
Sbjct: 601 ESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGALVHLLDLPCV 660
Query: 661 PPPPAPIPDLKVFEREGVQLNLSFIRPPENPALLLITITATNFSEGDVTHFICQAAVPKS 720
PPPPAPIPDLKVFEREGVQLNLSFIRPPENPALLLITITATNFSEGDVTHFICQAAVPKS
Sbjct: 661 PPPPAPIPDLKVFEREGVQLNLSFIRPPENPALLLITITATNFSEGDVTHFICQAAVPKS 720
Query: 721 LQLQLQAPSGNTVPARGGLPITQLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLP 780
LQLQLQAPSGNTVPARGGLPITQLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLP
Sbjct: 721 LQLQLQAPSGNTVPARGGLPITQLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLP 780
Query: 781 VESWQ 785
VESWQ
Sbjct: 781 VESWQ 785
>gi|71772942 adaptor-related protein complex 1, gamma 1 subunit
isoform b [Homo sapiens]
Length = 822
Score = 941 bits (2433), Expect = 0.0
Identities = 490/821 (59%), Positives = 619/821 (75%), Gaps = 44/821 (5%)
Query: 6 LKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAH 65
++L++LI IR A+TQA+ERE+IQKECA IR+SFR+ D +R R +AKLLY+HMLGYPAH
Sbjct: 5 IRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAH 64
Query: 66 FGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALC 125
FGQ+ECLKLIAS +FTDKR+GYLGAMLLLDER D HLL+TN IKNDL+ Q VQGLALC
Sbjct: 65 FGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALC 124
Query: 126 TLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLH 185
TL MGS+EMCRDLA EVEKLL + Y+RKKA L AVH+IRKVPEL +FLP LL+
Sbjct: 125 TLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLN 184
Query: 186 ERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPF 245
E++HG+L ++ L+TE+CERSP L HFRK+VPQLV IL+ L+ GYS EH +SG+SDPF
Sbjct: 185 EKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPF 244
Query: 246 LQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAG 305
LQV+ILRLLRILGRN ++SSE MND+LAQVATNT+TS+N GNA+L+ETVLTIMDI+S +G
Sbjct: 245 LQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESG 304
Query: 306 LRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRR 365
LRVLA+NILGRFLLN+D+NIRYVALTSLL+ VQ+DH+AVQRHR T+V+CL++ D S+ RR
Sbjct: 305 LRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRR 364
Query: 366 ALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILH 425
A+ELS ALVN +N+R MM+EL FL+SC P+ +ADCASGI LAAE++AP+KRWHIDTI+
Sbjct: 365 AMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMR 424
Query: 426 VLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWCIGEYG 485
VLTTAG++VRDDAV NL QLI + E+HAY+V+RLY A+ D SQQPLVQVAAWCIGEYG
Sbjct: 425 VLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYG 484
Query: 486 DLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNRI 545
DLL++G CEE EP+QV E+EVL +LE VL S+MS TRGYALTA+MKLSTR NRI
Sbjct: 485 DLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRI 544
Query: 546 RQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAILEKMPLVER---DGPQADEEAKES 602
++VVSIYGS +DVELQQRAVEY+ LF+KYDHMR+A+LE+MP++E+ +GP +
Sbjct: 545 KKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQTNGE 604
Query: 603 KEAAQLSEAAPVPTEPQ-ASQLLDLLDLLDGASGDV-----QHPPHLDPSPGGALVHLL- 655
E A L E P P+ PQ SQ DLLDLL G D+ P S GG L+ LL
Sbjct: 605 TEPAPL-ETKPPPSGPQPTSQANDLLDLLGG--NDITPVIPTAPTSKPSSAGGELLDLLG 661
Query: 656 ---------------DLPCVPPPP----------------APIPDLKVFEREGVQLNLSF 684
+P + PP A IP + + + G+++ +F
Sbjct: 662 DINLTGAPAAAPAPASVPQISQPPFLLDGLSSQPLFNDIAAGIPSITAYSKNGLKIEFTF 721
Query: 685 IRPPENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPITQL 744
R NP++ +ITI A+N +E D+T F+ QAAVPK+ QLQL +PS + VPA ITQ+
Sbjct: 722 ERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSIVPAFNTGTITQV 781
Query: 745 FRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLPVESWQ 785
++LNP K LR++++LTY+H ++Q++ EVNN P +SWQ
Sbjct: 782 IKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ 822
>gi|71773010 adaptor-related protein complex 1, gamma 1 subunit
isoform a [Homo sapiens]
Length = 825
Score = 936 bits (2419), Expect = 0.0
Identities = 490/824 (59%), Positives = 619/824 (75%), Gaps = 47/824 (5%)
Query: 6 LKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAH 65
++L++LI IR A+TQA+ERE+IQKECA IR+SFR+ D +R R +AKLLY+HMLGYPAH
Sbjct: 5 IRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAH 64
Query: 66 FGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALC 125
FGQ+ECLKLIAS +FTDKR+GYLGAMLLLDER D HLL+TN IKNDL+ Q VQGLALC
Sbjct: 65 FGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALC 124
Query: 126 TLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLH 185
TL MGS+EMCRDLA EVEKLL + Y+RKKA L AVH+IRKVPEL +FLP LL+
Sbjct: 125 TLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLN 184
Query: 186 ERHHGILLGTITLITELCERSPAALRHFRK---VVPQLVHILRTLVTMGYSTEHSISGVS 242
E++HG+L ++ L+TE+CERSP L HFRK +VPQLV IL+ L+ GYS EH +SG+S
Sbjct: 185 EKNHGVLHTSVVLLTEMCERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGIS 244
Query: 243 DPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRS 302
DPFLQV+ILRLLRILGRN ++SSE MND+LAQVATNT+TS+N GNA+L+ETVLTIMDI+S
Sbjct: 245 DPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKS 304
Query: 303 AAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASL 362
+GLRVLA+NILGRFLLN+D+NIRYVALTSLL+ VQ+DH+AVQRHR T+V+CL++ D S+
Sbjct: 305 ESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSI 364
Query: 363 SRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDT 422
RRA+ELS ALVN +N+R MM+EL FL+SC P+ +ADCASGI LAAE++AP+KRWHIDT
Sbjct: 365 KRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDT 424
Query: 423 ILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVAAWCIG 482
I+ VLTTAG++VRDDAV NL QLI + E+HAY+V+RLY A+ D SQQPLVQVAAWCIG
Sbjct: 425 IMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIG 484
Query: 483 EYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDN 542
EYGDLL++G CEE EP+QV E+EVL +LE VL S+MS TRGYALTA+MKLSTR
Sbjct: 485 EYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTV 544
Query: 543 NRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAILEKMPLVER---DGPQADEEA 599
NRI++VVSIYGS +DVELQQRAVEY+ LF+KYDHMR+A+LE+MP++E+ +GP +
Sbjct: 545 NRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQT 604
Query: 600 KESKEAAQLSEAAPVPTEPQ-ASQLLDLLDLLDGASGDV-----QHPPHLDPSPGGALVH 653
E A L E P P+ PQ SQ DLLDLL G D+ P S GG L+
Sbjct: 605 NGETEPAPL-ETKPPPSGPQPTSQANDLLDLLGG--NDITPVIPTAPTSKPSSAGGELLD 661
Query: 654 LL----------------DLPCVPPPP----------------APIPDLKVFEREGVQLN 681
LL +P + PP A IP + + + G+++
Sbjct: 662 LLGDINLTGAPAAAPAPASVPQISQPPFLLDGLSSQPLFNDIAAGIPSITAYSKNGLKIE 721
Query: 682 LSFIRPPENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLPI 741
+F R NP++ +ITI A+N +E D+T F+ QAAVPK+ QLQL +PS + VPA I
Sbjct: 722 FTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSIVPAFNTGTI 781
Query: 742 TQLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLPVESWQ 785
TQ+ ++LNP K LR++++LTY+H ++Q++ EVNN P +SWQ
Sbjct: 782 TQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ 825
>gi|19913414 adaptor-related protein complex 2, alpha 1 subunit
isoform 1 [Homo sapiens]
Length = 977
Score = 262 bits (669), Expect = 1e-69
Identities = 209/725 (28%), Positives = 355/725 (48%), Gaps = 63/725 (8%)
Query: 12 IEEIRGAKTQAQEREVIQKECAHIRASFRDG---DPVHRHRQLAKLLYVHMLGYPAHFGQ 68
I +IR K++ E + I KE A+IR+ F+ D + + + KLL++ +LG+ FG
Sbjct: 17 ISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGH 76
Query: 69 MECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLS 128
ME + L++S+++T+K++GYL +L++ + LI N+IKNDL+ LAL ++
Sbjct: 77 MEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIA 136
Query: 129 TMGSAEMCRDLAPEVEKLLLQPSPY--VRKKAILTAVHMIRKVPELSSV--FLPPCAQLL 184
+GS EM A ++ ++L+ V++ A L + + + P+L + + LL
Sbjct: 137 NVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLL 196
Query: 185 HERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYST--EHSISGVS 242
+++H G++ ++LIT LC+++P F+ V V L +V+ + +++ V
Sbjct: 197 NDQHMGVVTAAVSLITCLCKKNPD---DFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVP 253
Query: 243 DPFLQVQILRLLR---------ILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFET 293
P+L V++LRLL+ + GR E +N + NA NA+LFET
Sbjct: 254 APWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFET 313
Query: 294 VLTIMDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSD--HSAVQRHRPTV 351
+ I+ S L V A N LG+FL + + N+RY+AL S+ L S+ H AV+ H TV
Sbjct: 314 ISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTV 373
Query: 352 VECLR-ETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAE 410
+ L+ E D S+ +RA +L A+ + SN + ++ E+ +LE+ +R + + + AE
Sbjct: 374 INALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAE 433
Query: 411 RFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQ 470
++A W++DTIL+++ AG +V ++ + Q++ ++ Y+ + ++ AL
Sbjct: 434 KYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACH 493
Query: 471 QPLVQVAAWCIGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTA 530
+ +V+V + +GE+G+ L+AG+ P+Q +LL + H+ ATR L+
Sbjct: 494 ENMVKVGGYILGEFGN-LIAGDPRSSPPVQ------FSLLHS--KFHLCSVATRALLLST 544
Query: 531 LMKLSTRLCGDNNRIRQVVSIYGSCL---DVELQQRAVEYDTLFR-KYDHMRAAILEKMP 586
+K L + Q V GS L DVELQQRAVEY TL + A +LE+MP
Sbjct: 545 YIKF-INLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMP 603
Query: 587 ------------LVERDGPQADEEAKESKEAAQLSE--AAPVPTEPQASQLLDLLDLLDG 632
L + GP A + + ++ PT S DLL
Sbjct: 604 PFPERESSILAKLKRKKGPGAGSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADLLGL 663
Query: 633 ASGDVQHPPHLDPSPGGALVHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIRP--PEN 690
+ P G LV + D P P P P+ + LS + P PE+
Sbjct: 664 RAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPE---------EAFLSELEPPAPES 714
Query: 691 PALLL 695
P LL
Sbjct: 715 PMALL 719
>gi|19913416 adaptor-related protein complex 2, alpha 1 subunit
isoform 2 [Homo sapiens]
Length = 955
Score = 260 bits (664), Expect = 4e-69
Identities = 201/697 (28%), Positives = 344/697 (49%), Gaps = 52/697 (7%)
Query: 12 IEEIRGAKTQAQEREVIQKECAHIRASFRDG---DPVHRHRQLAKLLYVHMLGYPAHFGQ 68
I +IR K++ E + I KE A+IR+ F+ D + + + KLL++ +LG+ FG
Sbjct: 17 ISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGH 76
Query: 69 MECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLS 128
ME + L++S+++T+K++GYL +L++ + LI N+IKNDL+ LAL ++
Sbjct: 77 MEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIA 136
Query: 129 TMGSAEMCRDLAPEVEKLLLQPSPY--VRKKAILTAVHMIRKVPELSSV--FLPPCAQLL 184
+GS EM A ++ ++L+ V++ A L + + + P+L + + LL
Sbjct: 137 NVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLL 196
Query: 185 HERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYST--EHSISGVS 242
+++H G++ ++LIT LC+++P F+ V V L +V+ + +++ V
Sbjct: 197 NDQHMGVVTAAVSLITCLCKKNPD---DFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVP 253
Query: 243 DPFLQVQILRLLR---------ILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFET 293
P+L V++LRLL+ + GR E +N + NA NA+LFET
Sbjct: 254 APWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFET 313
Query: 294 VLTIMDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSD--HSAVQRHRPTV 351
+ I+ S L V A N LG+FL + + N+RY+AL S+ L S+ H AV+ H TV
Sbjct: 314 ISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTV 373
Query: 352 VECLR-ETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAE 410
+ L+ E D S+ +RA +L A+ + SN + ++ E+ +LE+ +R + + + AE
Sbjct: 374 INALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAE 433
Query: 411 RFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQ 470
++A W++DTIL+++ AG +V ++ + Q++ ++ Y+ + ++ AL
Sbjct: 434 KYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACH 493
Query: 471 QPLVQVAAWCIGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTA 530
+ +V+V + +GE+G+ L+AG+ P+Q +LL + H+ ATR L+
Sbjct: 494 ENMVKVGGYILGEFGN-LIAGDPRSSPPVQ------FSLLHS--KFHLCSVATRALLLST 544
Query: 531 LMKLSTRLCGDNNRIRQVVSIYGSCL---DVELQQRAVEYDTLFR-KYDHMRAAILEKMP 586
+K L + Q V GS L DVELQQRAVEY TL + A +LE+MP
Sbjct: 545 YIKF-INLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMP 603
Query: 587 ------------LVERDGPQADEEAKESKEAAQLSE--AAPVPTEPQASQLLDLLDLLDG 632
L + GP A + + ++ PT S DLL
Sbjct: 604 PFPERESSILAKLKRKKGPGAGSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADLLGL 663
Query: 633 ASGDVQHPPHLDPSPGGALVHLLDLPCVPPPPAPIPD 669
+ P G LV + D P P P P+
Sbjct: 664 RAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPE 700
>gi|27477041 adaptor-related protein complex 2, alpha 2 subunit
[Homo sapiens]
Length = 939
Score = 253 bits (646), Expect = 5e-67
Identities = 203/686 (29%), Positives = 339/686 (49%), Gaps = 56/686 (8%)
Query: 12 IEEIRGAKTQAQEREVIQKECAHIRASFRDG---DPVHRHRQLAKLLYVHMLGYPAHFGQ 68
I +IR K++ E + I KE A+IR+ F+ D + + + KLL++ +LG+ FG
Sbjct: 17 ISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGH 76
Query: 69 MECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLS 128
ME + L++S+R+T+K++GYL +L++ + LI N+IKNDL+ GLAL ++
Sbjct: 77 MEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIA 136
Query: 129 TMGSAEMCRDLAPEVEKLLL--QPSPYVRKKAILTAVHMIRKVPELSSV--FLPPCAQLL 184
++GS EM A E+ K+L+ V++ A L + + R P+L + + LL
Sbjct: 137 SVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLL 196
Query: 185 HERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYS--TEHSISGVS 242
+++H G++ +LIT L +++P F+ V V L +VT + +++ V
Sbjct: 197 NDQHLGVVTAATSLITTLAQKNP---EEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVP 253
Query: 243 DPFLQVQILRLLR--------ILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETV 294
P+L V++LRLL+ + GR E +N + NA NAVLFE +
Sbjct: 254 APWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAI 313
Query: 295 LTIMDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSD--HSAVQRHRPTVV 352
I+ S L V A N LG+FL + + N+RY+AL S+ L S+ H AV+ H TV+
Sbjct: 314 SLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVI 373
Query: 353 ECLR-ETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAER 411
L+ E D S+ +RA++L A+ + SN ++ E+ ++LE+ +R + + + AE+
Sbjct: 374 NALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEK 433
Query: 412 FAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQ 471
+A W++DTIL+++ AG +V ++ + Q++ ++ Y+ + ++ AL +
Sbjct: 434 YAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHE 493
Query: 472 PLVQVAAWCIGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTAL 531
LV+V + +GE+G+ L+AG+ +Q LL + H+ TR L+
Sbjct: 494 NLVKVGGYILGEFGN-LIAGDPRSSPLIQ------FHLLHS--KFHLCSVPTRALLLSTY 544
Query: 532 MKLSTRLCGDNNRIRQVVSIYGSC--LDVELQQRAVEYDTLFR-KYDHMRAAILEKMPLV 588
+K I+ V+ DVELQQRAVEY L + A +LE+MP
Sbjct: 545 IKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMP-- 602
Query: 589 ERDGPQADEEAKESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPG 648
P + E+ S A + + S + DL D S DV P P+
Sbjct: 603 ----PFPERES---------SILAKLKKKKGPSTVTDLEDTKRDRSVDVNGGPEPAPAST 649
Query: 649 GAL------VHLLDLPCVPPPPAPIP 668
A+ LL L PP PA P
Sbjct: 650 SAVSTPSPSADLLGLGAAPPAPAGPP 675
>gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit
[Homo sapiens]
Length = 1137
Score = 216 bits (549), Expect = 9e-56
Identities = 152/589 (25%), Positives = 281/589 (47%), Gaps = 26/589 (4%)
Query: 5 SLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQ--LAKLLYVHMLGY 62
S +L L+ I ++ +E ++IQ+E + ++A+ + + + +L+Y MLGY
Sbjct: 33 SSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGY 92
Query: 63 PAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGL 122
A FG + +KL +KRVGYL L L E H+ LL+ N++ DL +
Sbjct: 93 DASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCM 152
Query: 123 ALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQ 182
AL +S + EM + P +E L VR+KA+L P +
Sbjct: 153 ALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRK 212
Query: 183 LLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVS 242
L +R G++ ++ + + + + + ++ + V IL+ +V E + V
Sbjct: 213 ALCDRDVGVMAASLHIYLRMIKENSSG---YKDLTGSFVTILKQVVGGKLPVEFNYHSVP 269
Query: 243 DPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRS 302
P+LQ+Q+LR+L +LG++ + +SE M D+L + + + N A+LFE V T+ I
Sbjct: 270 APWLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYP 329
Query: 303 AAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASL 362
+ L A +G+F+L+ N++Y+ L +L ++Q D + +H+ T++ECL D +
Sbjct: 330 KSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPII 389
Query: 363 SRRALELSLALVNSSNVRAMMQELQAFLESCPPD-LRADCASGILLAAERFAPTKRWHID 421
R LEL + N+ N+ ++Q++ +L + + + I AE++AP W I
Sbjct: 390 KRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQ 449
Query: 422 TILHVLTTAGTHVRDDAVANLTQLIGGA-------QELHAYSVRRLYNALAED--ISQQP 472
T+ V + G + D N +L+ Q+L Y+V+ L + Q
Sbjct: 450 TMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENVFYPQR 509
Query: 473 LVQVAAWCIGEYGDLLLAGNCEEIEPLQVDEEEVLALLEKVLQSHMSLPATRGYALTALM 532
+QV +W +GEY LL ++ P EEV+A L K+L + T+ + + A+
Sbjct: 510 FLQVMSWVLGEYSYLL-----DKETP-----EEVIAKLYKLLMNDSVSSETKAWLIAAVT 559
Query: 533 KLSTRLCGDNNRIRQVVSIYGSCLDVELQQRAVEYDTLFRKYDHMRAAI 581
KL+++ +N + +++ + LD ++Q A E L + M++ +
Sbjct: 560 KLTSQ-AHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENVELMKSLL 607
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 144 bits (364), Expect = 2e-34
Identities = 118/513 (23%), Positives = 236/513 (46%), Gaps = 66/513 (12%)
Query: 8 LQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFG 67
LQDL+ IR K E + I + I+ + + + + KL Y+ MLGY +
Sbjct: 18 LQDLVRGIRNHKED--EAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWA 75
Query: 68 QMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTL 127
++++++S+FT KR+GYL A E D +L TN I+ DLS Q G+AL L
Sbjct: 76 AFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGL 135
Query: 128 STMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHER 187
S + ++ RDLA ++ L+ PY+RKKA+L + K PE P + L +
Sbjct: 136 SCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDP 195
Query: 188 HHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQ 247
G+ + +I EL R+P +++ + P ++ + ++ ++
Sbjct: 196 DPGVQSAAVNVICELARRNP---KNYLSLAPLFFKLM--------------TSSTNNWVL 238
Query: 248 VQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDI------- 300
++I++L L + + + L + +T + ++L+E V T++ +
Sbjct: 239 IKIIKLFGALTPLEPRLGKKLIEPLTNLIHST-----SAMSLLYECVNTVIAVLISLSSG 293
Query: 301 --RSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRET 358
+A ++ L V L + +SD+N++Y+ L ++ +++++ +VQ H+ +++CL +
Sbjct: 294 MPNHSASIQ-LCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDK 352
Query: 359 DASLSRRALELSLALVNSSNVRAMMQELQAFLESCP-PDLRADCASGIL----LAAERFA 413
D S+ RAL+L +V+ N+ ++++L ++ R + + I+ + ++
Sbjct: 353 DESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYI 412
Query: 414 PTKRWHIDTILHVLTTAGTH------------------VRDDAVANLTQLIGGAQELHAY 455
W+I ++ + GT +R AV+ ++ L+ A L +
Sbjct: 413 TNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASS 472
Query: 456 SVRRLYNALAEDISQQPLVQVAAWCIGEYGDLL 488
+ R N + E ++ AAW GE+ + L
Sbjct: 473 TQR---NGICE------VLYAAAWICGEFSEHL 496
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 89.0 bits (219), Expect = 2e-17
Identities = 75/275 (27%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 8 LQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFG 67
LQDL+ IR K E + I + I+ + + + + KL Y+ MLGY +
Sbjct: 18 LQDLVRGIRNHKED--EAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWA 75
Query: 68 QMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTL 127
++++++S+FT KR+GYL A E D +L TN I+ DLS Q G+AL L
Sbjct: 76 AFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGL 135
Query: 128 STMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHER 187
S + ++ RDLA ++ L+ PY+RKKA L P + + LL+E
Sbjct: 136 SCFVTPDLARDLANDIMTLMSHTKPYIRKKAKLIE-------PLTNLIHSTSAMSLLYEC 188
Query: 188 HHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQ 247
+ ++ I+L + + S + + V LR L+ SD L+
Sbjct: 189 VNTVIAVLISLSSGMPNHSAS--------IQLCVQKLRILIE-----------DSDQNLK 229
Query: 248 VQILRLLRILGRNHEESSETMNDLLAQVATNTDTS 282
L + + + H +S ++ DL+ Q + D S
Sbjct: 230 YLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDES 264
Score = 56.2 bits (134), Expect = 1e-07
Identities = 43/203 (21%), Positives = 95/203 (46%), Gaps = 32/203 (15%)
Query: 309 LAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALE 368
L V L + +SD+N++Y+ L ++ +++++ +VQ H+ +++CL + D S+ RAL+
Sbjct: 212 LCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALD 271
Query: 369 LSLALVNSSNVRAMMQELQAFLESCP-PDLRADCASGIL----LAAERFAPTKRWHIDTI 423
L +V+ N+ ++++L ++ R + + I+ + ++ W+I +
Sbjct: 272 LLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISIL 331
Query: 424 LHVLTTAGTH------------------VRDDAVANLTQLIGGAQELHAYSVRRLYNALA 465
+ + GT +R AV+ ++ L+ A L + + R N +
Sbjct: 332 VELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQR---NGIC 388
Query: 466 EDISQQPLVQVAAWCIGEYGDLL 488
E ++ AAW GE+ + L
Sbjct: 389 E------VLYAAAWICGEFSEHL 405
>gi|14719400 ADP-ribosylation factor binding protein 3 isoform short
[Homo sapiens]
Length = 690
Score = 72.4 bits (176), Expect = 2e-12
Identities = 57/200 (28%), Positives = 93/200 (46%), Gaps = 15/200 (7%)
Query: 597 EEAKESKEAAQLSEAAPVPTEPQASQLLDLLD-----LLDGASGDVQHPPHLDPSPGGAL 651
EEAK + + + + +PT A LL L S Q P P A
Sbjct: 491 EEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLAS 550
Query: 652 VHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIR--PPENPALLLITITATNFSEGDVT 709
+H+ P P+ + +++ G ++ F + PP P +L++ ++ N + V
Sbjct: 551 IHV---PLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVK 607
Query: 710 HFICQAAVPKSLQLQLQAPSGNTV----PARGGLPITQLFRILNPNKAPLRLKLRLTYDH 765
+ QAAVPKS++++LQ PSG + P + ITQ+ + NP K +RL+ +LT+
Sbjct: 608 SIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFAL 667
Query: 766 FHQSVQEIFEVNNL-PVESW 784
Q E+ EV+ PVE W
Sbjct: 668 GEQLSTEVGEVDQFPPVEQW 687
>gi|20336267 ADP-ribosylation factor binding protein 3 isoform long
[Homo sapiens]
Length = 723
Score = 72.4 bits (176), Expect = 2e-12
Identities = 57/200 (28%), Positives = 93/200 (46%), Gaps = 15/200 (7%)
Query: 597 EEAKESKEAAQLSEAAPVPTEPQASQLLDLLD-----LLDGASGDVQHPPHLDPSPGGAL 651
EEAK + + + + +PT A LL L S Q P P A
Sbjct: 524 EEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLAS 583
Query: 652 VHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIR--PPENPALLLITITATNFSEGDVT 709
+H+ P P+ + +++ G ++ F + PP P +L++ ++ N + V
Sbjct: 584 IHV---PLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVK 640
Query: 710 HFICQAAVPKSLQLQLQAPSGNTV----PARGGLPITQLFRILNPNKAPLRLKLRLTYDH 765
+ QAAVPKS++++LQ PSG + P + ITQ+ + NP K +RL+ +LT+
Sbjct: 641 SIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFAL 700
Query: 766 FHQSVQEIFEVNNL-PVESW 784
Q E+ EV+ PVE W
Sbjct: 701 GEQLSTEVGEVDQFPPVEQW 720
>gi|9558751 ADP-ribosylation factor binding protein 2 [Homo sapiens]
Length = 613
Score = 68.9 bits (167), Expect = 2e-11
Identities = 45/146 (30%), Positives = 78/146 (53%), Gaps = 8/146 (5%)
Query: 643 LDPSPGGALVHLLDL--PCVPPPPAPIPDLKVFEREGVQLNLSFIRP--PENPALLLITI 698
L PSP L + P P+ +P L V++R G ++ L F + P +P + ++ +
Sbjct: 460 LAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLL 519
Query: 699 TATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGLP----ITQLFRILNPNKAP 754
T + + V + Q AVPKS++++LQ S + +PA L I+Q+ + NP+K P
Sbjct: 520 TMMSTAPQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQMLLLDNPHKEP 579
Query: 755 LRLKLRLTYDHFHQSVQEIFEVNNLP 780
+RL+ +LT++ Q E+ EV + P
Sbjct: 580 IRLRYKLTFNQGGQPFSEVGEVKDFP 605
>gi|9558729 golgi associated, gamma adaptin ear containing, ARF
binding protein 1 isoform 1 [Homo sapiens]
Length = 639
Score = 65.9 bits (159), Expect = 1e-10
Identities = 44/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%)
Query: 629 LLDGASGDVQHPPHLDPSPGGALVHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIRPP 688
LL S + PP P P + + +P P+ I + V+++ G ++ F R P
Sbjct: 475 LLHTVSPEPPRPPQ-QPVPTELSLASITVPLESIKPSNILPVTVYDQHGFRILFHFARDP 533
Query: 689 --ENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGL----PIT 742
+L++ ++ + + + + + Q+AVPK ++++LQ PSG +PA + IT
Sbjct: 534 LPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAIT 593
Query: 743 QLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNL-PVESW 784
Q+ + NP K +RL+ +LT+ Q+ E+ +V+ P E+W
Sbjct: 594 QVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGDVDQFPPPETW 636
>gi|48527952 golgi associated, gamma adaptin ear containing, ARF
binding protein 1 isoform 2 [Homo sapiens]
Length = 552
Score = 65.9 bits (159), Expect = 1e-10
Identities = 44/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%)
Query: 629 LLDGASGDVQHPPHLDPSPGGALVHLLDLPCVPPPPAPIPDLKVFEREGVQLNLSFIRPP 688
LL S + PP P P + + +P P+ I + V+++ G ++ F R P
Sbjct: 388 LLHTVSPEPPRPPQ-QPVPTELSLASITVPLESIKPSNILPVTVYDQHGFRILFHFARDP 446
Query: 689 --ENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQLQAPSGNTVPARGGL----PIT 742
+L++ ++ + + + + + Q+AVPK ++++LQ PSG +PA + IT
Sbjct: 447 LPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFNPIVHPSAIT 506
Query: 743 QLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNL-PVESW 784
Q+ + NP K +RL+ +LT+ Q+ E+ +V+ P E+W
Sbjct: 507 QVLLLANPQKEKVRLRYKLTFTMGDQTYNEMGDVDQFPPPETW 549
>gi|239758145 PREDICTED: similar to ADP-ribosylation factor binding
protein 2 [Homo sapiens]
Length = 134
Score = 64.3 bits (155), Expect = 4e-10
Identities = 38/120 (31%), Positives = 69/120 (57%), Gaps = 6/120 (5%)
Query: 667 IPDLKVFEREGVQLNLSFIRP--PENPALLLITITATNFSEGDVTHFICQAAVPKSLQLQ 724
+P L V++R G ++ L F + P +P + ++ +T + + V + Q AVPKS++++
Sbjct: 7 LPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTAPQPVWDIMFQVAVPKSMRVK 66
Query: 725 LQAPSGNTVPARGGLP----ITQLFRILNPNKAPLRLKLRLTYDHFHQSVQEIFEVNNLP 780
LQ S + +PA L I+Q+ + NP+K P+RL+ +LT++ Q E+ EV + P
Sbjct: 67 LQPASSSKLPAFSPLMPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFP 126
>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
isoform a [Homo sapiens]
Length = 949
Score = 57.8 bits (138), Expect = 4e-08
Identities = 93/495 (18%), Positives = 195/495 (39%), Gaps = 45/495 (9%)
Query: 83 KRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPE 142
K++ YL M + D ++ N+ D ++ LA+ T+ + ++ L
Sbjct: 66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
Query: 143 VEKLLLQPSPYVRKKA--ILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLIT 200
+ K L PYVRK A + +H I FL L+ + + ++ + ++
Sbjct: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALS 185
Query: 201 ELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRN 260
E+ E P++ + + PQ ++ + L + TE Q+ IL L
Sbjct: 186 EIAESHPSS--NLLDLNPQSIN--KLLTALNECTEWG---------QIFILDCLANYMPK 232
Query: 261 HEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAG---------LRVLAV 311
+ ++++ + + T +A +AV+ V +M L+ LA
Sbjct: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAP 286
Query: 312 NILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSL 371
++ LL+++ ++YVAL ++ +VQ + +H V + L++ +
Sbjct: 287 PLV--TLLSAEPELQYVALRNINLIVQK-RPEILKHEMKVFFVKYNDPIYVKLEKLDIMI 343
Query: 372 ALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAG 431
L + +N+ ++ EL+ + D I A + + + T+L ++ T
Sbjct: 344 RLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKV 403
Query: 432 THVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVA-AWCIGEYGDLLLA 490
+V +A+ + + + + L L D +P + A W +GEY + +
Sbjct: 404 NYVVQEAIVVIKDIFRKYPNKYESVIATLCENL--DSLDEPEARAAMIWIVGEYAERI-- 459
Query: 491 GNCEE-----IEPLQVDEEEV-LALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNR 544
N +E +E + +V L LL +++ + P + ++ L+T+ DN
Sbjct: 460 DNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQ-DSDNPD 518
Query: 545 IRQVVSIYGSCLDVE 559
+R IY L +
Sbjct: 519 LRDRGYIYWRLLSTD 533
>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
isoform b [Homo sapiens]
Length = 942
Score = 57.8 bits (138), Expect = 4e-08
Identities = 93/495 (18%), Positives = 195/495 (39%), Gaps = 45/495 (9%)
Query: 83 KRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPE 142
K++ YL M + D ++ N+ D ++ LA+ T+ + ++ L
Sbjct: 66 KKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
Query: 143 VEKLLLQPSPYVRKKA--ILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLIT 200
+ K L PYVRK A + +H I FL L+ + + ++ + ++
Sbjct: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALS 185
Query: 201 ELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRN 260
E+ E P++ + + PQ ++ + L + TE Q+ IL L
Sbjct: 186 EIAESHPSS--NLLDLNPQSIN--KLLTALNECTEWG---------QIFILDCLANYMPK 232
Query: 261 HEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAG---------LRVLAV 311
+ ++++ + + T +A +AV+ V +M L+ LA
Sbjct: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAP 286
Query: 312 NILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSL 371
++ LL+++ ++YVAL ++ +VQ + +H V + L++ +
Sbjct: 287 PLV--TLLSAEPELQYVALRNINLIVQK-RPEILKHEMKVFFVKYNDPIYVKLEKLDIMI 343
Query: 372 ALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAG 431
L + +N+ ++ EL+ + D I A + + + T+L ++ T
Sbjct: 344 RLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKV 403
Query: 432 THVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVA-AWCIGEYGDLLLA 490
+V +A+ + + + + L L D +P + A W +GEY + +
Sbjct: 404 NYVVQEAIVVIKDIFRKYPNKYESVIATLCENL--DSLDEPEARAAMIWIVGEYAERI-- 459
Query: 491 GNCEE-----IEPLQVDEEEV-LALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNR 544
N +E +E + +V L LL +++ + P + ++ L+T+ DN
Sbjct: 460 DNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQ-DSDNPD 518
Query: 545 IRQVVSIYGSCLDVE 559
+R IY L +
Sbjct: 519 LRDRGYIYWRLLSTD 533
>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
sapiens]
Length = 1094
Score = 56.2 bits (134), Expect = 1e-07
Identities = 89/456 (19%), Positives = 188/456 (41%), Gaps = 48/456 (10%)
Query: 72 LKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMG 131
+K +AS K++ Y+ + +E+ D LL ++ + L Q ++ AL LS++
Sbjct: 84 VKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIR 143
Query: 132 SAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKV----PELSSVFLPPCAQLLHER 187
+ + +++ SPYVRK A H I+K+ PE + + +LL ++
Sbjct: 144 VPIIVPIMMLAIKEASADLSPYVRK----NAAHAIQKLYSLDPEQKEMLIEVIEKLLKDK 199
Query: 188 HHGILLGTITLITELC-ERSPAALRHFRKVVPQLVHILR--TLVTMGYSTEHSISGVSDP 244
+ + E+C +R +++RK+ LV + +V + T ++ + P
Sbjct: 200 STLVAGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSP 259
Query: 245 FLQVQILRLLRILGRNHEESSETMND----------------LLAQVATNTDTSRNAGNA 288
+ + L G+N ES + + LL + SRNA
Sbjct: 260 WKEGD---ELEDNGKNFYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVV 316
Query: 289 VLFETVLTIMDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHR 348
+ + + +S AG +++ +++ LL S+R ++Y+ L ++ + + +
Sbjct: 317 MAVAQLYWHISPKSEAG--IISKSLVR--LLRSNREVQYIVLQNIATMSIQRKGMFEPYL 372
Query: 349 PTVVECLRETDASLSRR-ALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILL 407
+ +R TD ++ + LE+ L N +N+ +++E Q +++S A I
Sbjct: 373 KSFY--VRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGR 430
Query: 408 AAERFAPTKRWHIDTILHVLTTAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAED 467
A ++ ++ +L+ V ++V + +L+ H ++ + L D
Sbjct: 431 CATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLL--D 488
Query: 468 ISQQPLVQVA-AWCIGEYGDLLLAGNCEEIEPLQVD 502
P+ + + W IGE NCE + + D
Sbjct: 489 SITVPVARASILWLIGE--------NCERVPKIAPD 516
>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
isoform a [Homo sapiens]
Length = 951
Score = 54.3 bits (129), Expect = 4e-07
Identities = 94/495 (18%), Positives = 193/495 (38%), Gaps = 45/495 (9%)
Query: 83 KRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPE 142
K++ YL M + D ++ NS D ++ LA+ T+ + ++ L
Sbjct: 66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
Query: 143 VEKLLLQPSPYVRKKA--ILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLIT 200
+ K L PYVRK A + +H I FL L+ + + ++ + ++
Sbjct: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALS 185
Query: 201 ELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRN 260
E+ E P + + + PQ +I + L + TE Q+ IL L
Sbjct: 186 EISESHPNS--NLLDLNPQ--NINKLLTALNECTEWG---------QIFILDCLSNYNPK 232
Query: 261 HEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAG---------LRVLAV 311
+ ++++ + + T +A +AV+ V +M L+ LA
Sbjct: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAP 286
Query: 312 NILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSL 371
++ LL+ + ++YVAL ++ +VQ + + V + L++ +
Sbjct: 287 PLV--TLLSGEPEVQYVALRNINLIVQK-RPEILKQEIKVFFVKYNDPIYVKLEKLDIMI 343
Query: 372 ALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAG 431
L + +N+ ++ EL+ + D I A + + + T+L ++ T
Sbjct: 344 RLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKV 403
Query: 432 THVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVA-AWCIGEYGDLLLA 490
+V +A+ + + + + L L D +P + A W +GEY + +
Sbjct: 404 NYVVQEAIVVIRDIFRKYPNKYESIIATLCENL--DSLDEPDARAAMIWIVGEYAERI-- 459
Query: 491 GNCEE-----IEPLQVDEEEV-LALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNR 544
N +E +E + +V L LL +++ + P+ + ++ L+T+ DN
Sbjct: 460 DNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQ-DSDNPD 518
Query: 545 IRQVVSIYGSCLDVE 559
+R IY L +
Sbjct: 519 LRDRGYIYWRLLSTD 533
>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
isoform b [Homo sapiens]
Length = 937
Score = 54.3 bits (129), Expect = 4e-07
Identities = 94/495 (18%), Positives = 193/495 (38%), Gaps = 45/495 (9%)
Query: 83 KRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPE 142
K++ YL M + D ++ NS D ++ LA+ T+ + ++ L
Sbjct: 66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125
Query: 143 VEKLLLQPSPYVRKKA--ILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLIT 200
+ K L PYVRK A + +H I FL L+ + + ++ + ++
Sbjct: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALS 185
Query: 201 ELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRN 260
E+ E P + + + PQ +I + L + TE Q+ IL L
Sbjct: 186 EISESHPNS--NLLDLNPQ--NINKLLTALNECTEWG---------QIFILDCLSNYNPK 232
Query: 261 HEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAG---------LRVLAV 311
+ ++++ + + T +A +AV+ V +M L+ LA
Sbjct: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAP 286
Query: 312 NILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSL 371
++ LL+ + ++YVAL ++ +VQ + + V + L++ +
Sbjct: 287 PLV--TLLSGEPEVQYVALRNINLIVQK-RPEILKQEIKVFFVKYNDPIYVKLEKLDIMI 343
Query: 372 ALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAG 431
L + +N+ ++ EL+ + D I A + + + T+L ++ T
Sbjct: 344 RLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKV 403
Query: 432 THVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVA-AWCIGEYGDLLLA 490
+V +A+ + + + + L L D +P + A W +GEY + +
Sbjct: 404 NYVVQEAIVVIRDIFRKYPNKYESIIATLCENL--DSLDEPDARAAMIWIVGEYAERI-- 459
Query: 491 GNCEE-----IEPLQVDEEEV-LALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNR 544
N +E +E + +V L LL +++ + P+ + ++ L+T+ DN
Sbjct: 460 DNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQ-DSDNPD 518
Query: 545 IRQVVSIYGSCLDVE 559
+R IY L +
Sbjct: 519 LRDRGYIYWRLLSTD 533
>gi|166197671 adaptor-related protein complex 4, beta 1 subunit
[Homo sapiens]
Length = 739
Score = 51.2 bits (121), Expect = 4e-06
Identities = 91/433 (21%), Positives = 165/433 (38%), Gaps = 50/433 (11%)
Query: 69 MECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLS 128
ME +K A+ K++ YL + D LL N++ D S V+GLAL
Sbjct: 51 MEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLAL---- 106
Query: 129 TMGSAEMCRDLAPEVEKLLLQP--------SPYVRKKAIL--TAVHMIRKVPELSSVFLP 178
MC P V++ + QP + YVR+ A+L +H + E+ +
Sbjct: 107 ----RSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVN 162
Query: 179 PCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSI 238
LL ++ +++ + + E+ ++ + + P H+L + +
Sbjct: 163 ELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVIN----KPIAHHLLNRMSKL-------- 210
Query: 239 SGVSDPFLQVQILR-LLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTI 297
D + Q ++L LLR R+ EE + +N LL ++ G LF +L
Sbjct: 211 ----DQWGQAEVLNFLLRYQPRSEEELFDILN-LLDSFLKSSSPGVVMGATKLF-LILAK 264
Query: 298 MDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRE 357
M + V L + R + +VAL + +++ S H C
Sbjct: 265 MFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFF-CSYS 323
Query: 358 TDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKR 417
+ + +E+ LVN NV+ +++EL+ + D+ AD A + A A R
Sbjct: 324 EPHYIKLQKVEVLCELVNDENVQQVLEELRGYC----TDVSADFAQAAIFAIGGIA---R 376
Query: 418 WHIDTILHVLT----TAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPL 473
+ D + +LT H+ V L+ + +V + E+I
Sbjct: 377 TYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQC-TEAVCQALPGCEENIQDSEG 435
Query: 474 VQVAAWCIGEYGD 486
Q W +G +G+
Sbjct: 436 KQALIWLLGVHGE 448
>gi|221316632 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 50.1 bits (118), Expect = 8e-06
Identities = 61/288 (21%), Positives = 118/288 (40%), Gaps = 35/288 (12%)
Query: 102 LLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILT 161
+L+ ++ + DL + ++G L L + AE+ L P + L YVR+ A+L
Sbjct: 99 ILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLA 158
Query: 162 AVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLV 221
+ R L +P +L+H+ L A+ + R L+
Sbjct: 159 IYTIYRNFEHL----IPDAPELIHD--------------FLVNEKDASCK--RNAFMMLI 198
Query: 222 HILRTLVTMGYSTEHSISGVSDPFLQVQILRLL-RILGRNHEESSETMNDLLAQVATNTD 280
H + ST LQ+ I+ L+ ++ N E + + + +
Sbjct: 199 HADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIY-------N 251
Query: 281 TSRNAGNAVLFETVLTIMDIRSA-AGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQS 339
+++ AV +E T++ + SA ++ A + + SD N++ + L L+ L
Sbjct: 252 LLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIEL--K 309
Query: 340 DHSAVQRHRPTVV----ECLRETDASLSRRALELSLALVNSSNVRAMM 383
+H A +R +V L D + ++ L+L+L LV+S NV ++
Sbjct: 310 EHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELV 357
>gi|221316630 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 50.1 bits (118), Expect = 8e-06
Identities = 61/288 (21%), Positives = 118/288 (40%), Gaps = 35/288 (12%)
Query: 102 LLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILT 161
+L+ ++ + DL + ++G L L + AE+ L P + L YVR+ A+L
Sbjct: 99 ILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLA 158
Query: 162 AVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLV 221
+ R L +P +L+H+ L A+ + R L+
Sbjct: 159 IYTIYRNFEHL----IPDAPELIHD--------------FLVNEKDASCK--RNAFMMLI 198
Query: 222 HILRTLVTMGYSTEHSISGVSDPFLQVQILRLL-RILGRNHEESSETMNDLLAQVATNTD 280
H + ST LQ+ I+ L+ ++ N E + + + +
Sbjct: 199 HADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIY-------N 251
Query: 281 TSRNAGNAVLFETVLTIMDIRSA-AGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQS 339
+++ AV +E T++ + SA ++ A + + SD N++ + L L+ L
Sbjct: 252 LLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIEL--K 309
Query: 340 DHSAVQRHRPTVV----ECLRETDASLSRRALELSLALVNSSNVRAMM 383
+H A +R +V L D + ++ L+L+L LV+S NV ++
Sbjct: 310 EHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELV 357
>gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]
Length = 953
Score = 50.1 bits (118), Expect = 8e-06
Identities = 61/288 (21%), Positives = 118/288 (40%), Gaps = 35/288 (12%)
Query: 102 LLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILT 161
+L+ ++ + DL + ++G L L + AE+ L P + L YVR+ A+L
Sbjct: 99 ILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLA 158
Query: 162 AVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLV 221
+ R L +P +L+H+ L A+ + R L+
Sbjct: 159 IYTIYRNFEHL----IPDAPELIHD--------------FLVNEKDASCK--RNAFMMLI 198
Query: 222 HILRTLVTMGYSTEHSISGVSDPFLQVQILRLL-RILGRNHEESSETMNDLLAQVATNTD 280
H + ST LQ+ I+ L+ ++ N E + + + +
Sbjct: 199 HADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIY-------N 251
Query: 281 TSRNAGNAVLFETVLTIMDIRSA-AGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQS 339
+++ AV +E T++ + SA ++ A + + SD N++ + L L+ L
Sbjct: 252 LLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIEL--K 309
Query: 340 DHSAVQRHRPTVV----ECLRETDASLSRRALELSLALVNSSNVRAMM 383
+H A +R +V L D + ++ L+L+L LV+S NV ++
Sbjct: 310 EHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELV 357
>gi|11559929 coatomer protein complex, subunit gamma 1 [Homo
sapiens]
Length = 874
Score = 48.1 bits (113), Expect = 3e-05
Identities = 69/397 (17%), Positives = 161/397 (40%), Gaps = 50/397 (12%)
Query: 24 EREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFGQMECL-------KLIA 76
E + ++CAHI L K+LY ++ H G E KL
Sbjct: 36 ETPINPRKCAHI---------------LTKILY--LINQGEHLGTTEATEAFFAMTKLFQ 78
Query: 77 SSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMC 136
S+ T +R+ YL + D +++T+S+ D++ +G A+ L + + M
Sbjct: 79 SNDPTLRRMCYLTIKEMSCIAEDV-IIVTSSLTKDMTGKEDNYRGPAVRALCQITDSTML 137
Query: 137 RDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTI 196
+ + +++ ++ P V A+++++H+++ ++ ++ + + + +
Sbjct: 138 QAIERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHAL 197
Query: 197 TLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRI 256
L L H RK V+ + + VT G+ PF ++R+
Sbjct: 198 GL-----------LYHVRKNDRLAVNKMISKVTR--------HGLKSPFAYCM---MIRV 235
Query: 257 LGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAGLRVL-AVNILG 315
+ EE + + L + RN V++E I+++ + + AV++L
Sbjct: 236 ASKQLEEEDGSRDSPLFDFIESC--LRNKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQ 293
Query: 316 RFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSLALVN 375
F + +RY A+ +L ++ SAV + + +++ S++ A+ L +
Sbjct: 294 LFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGS 353
Query: 376 SSNVRAMMQELQAFLESCPPDLRADCASGILLAAERF 412
S++ +M+++ +F+ + + I +++
Sbjct: 354 ESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKY 390
>gi|109134349 coatomer protein complex, subunit gamma 2 [Homo
sapiens]
Length = 871
Score = 46.6 bits (109), Expect = 9e-05
Identities = 62/371 (16%), Positives = 154/371 (41%), Gaps = 37/371 (9%)
Query: 51 LAKLLYVHMLGYPAHFGQMECL-------KLIASSRFTDKRVGYLGAMLLLDERHDAHLL 103
L K+LY +L HFG E +L S+ T +R+ YL + D ++
Sbjct: 48 LTKILY--LLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDV-II 104
Query: 104 ITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAV 163
+T+S+ D++ +G A+ L + M + + +++ ++ V A+++++
Sbjct: 105 VTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSL 164
Query: 164 HMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHI 223
HM++ ++ ++ + + + + ++ L + R V ++++
Sbjct: 165 HMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKND-------RLAVSKMLN- 216
Query: 224 LRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSET-MNDLLAQVATNTDTS 282
+ + SG+ F ++R+ L + E+ E+ + D +
Sbjct: 217 -----------KFTKSGLKSQFAYCMLIRIASRLLKETEDGHESPLFDFIESCL------ 259
Query: 283 RNAGNAVLFETVLTIMDIRSAAGLRVL-AVNILGRFLLNSDRNIRYVALTSLLRLVQSDH 341
RN V++E I+ + + + AV++L F + +RY A+ +L ++
Sbjct: 260 RNKHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHP 319
Query: 342 SAVQRHRPTVVECLRETDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADC 401
SAV + + +++ S++ A+ L + S+V +M+++ +F+ + +
Sbjct: 320 SAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVV 379
Query: 402 ASGILLAAERF 412
I +++
Sbjct: 380 VQAISALCQKY 390
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 37.0 bits (84), Expect = 0.071
Identities = 29/92 (31%), Positives = 39/92 (42%), Gaps = 14/92 (15%)
Query: 640 PPHLDPSPGGALVHLLDLPCVPPPP---APIPDLKVFEREGVQL----------NLSFIR 686
PP P+PG A+ L PC P P AP P LK+ + + + +
Sbjct: 714 PPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPL 773
Query: 687 PPENPALLLITITATNFSEGDVTHFICQAAVP 718
PP+ P L+TI A S V + QAA P
Sbjct: 774 PPQAPPKPLVTIPAPT-STKTVAPVVTQAAPP 804
>gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]
Length = 580
Score = 36.2 bits (82), Expect = 0.12
Identities = 42/154 (27%), Positives = 63/154 (40%), Gaps = 37/154 (24%)
Query: 598 EAKESKEAAQLS-------EAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGA 650
E +S ++QLS E P+P +P + ++L D++DG P PG
Sbjct: 179 ENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQPSDIMDG------------PDPGAP 226
Query: 651 LVHLLDLPCVPPP-PAPIPDLKVFEREGVQLNLSFIRPPENPALLLITITATNFSEGDVT 709
+ LPC+P P+P KV P P L L++ TA + V
Sbjct: 227 ----VKLPCLPVKLSPPLPPKKVM----------ICMPVGGPDLSLVSYTAQKSGQQGVA 272
Query: 710 HFICQAAVPKSLQLQLQAPS-GNTVPA-RGGLPI 741
+P +Q QLQ S G +P+ G LP+
Sbjct: 273 QH-HHTVLPSQIQHQLQYGSHGQHLPSTTGSLPM 305
>gi|88900505 tyrosine hydroxylase isoform c [Homo sapiens]
Length = 524
Score = 35.4 bits (80), Expect = 0.21
Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 16/95 (16%)
Query: 597 EEAKESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGALVHLLD 656
E+A++ +EAA + AA VP+EP GD + G A+++LL
Sbjct: 70 EDARKEREAAVAAAAAAVPSEP----------------GDPLEAVAFEEKEGKAVLNLLF 113
Query: 657 LPCVPPPPAPIPDLKVFEREGVQLNLSFIRPPENP 691
P P A +KVFE +++ RP + P
Sbjct: 114 SPRATKPSALSRAVKVFETFEAKIHHLETRPAQRP 148
>gi|88900501 tyrosine hydroxylase isoform a [Homo sapiens]
Length = 528
Score = 35.4 bits (80), Expect = 0.21
Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 16/95 (16%)
Query: 597 EEAKESKEAAQLSEAAPVPTEPQASQLLDLLDLLDGASGDVQHPPHLDPSPGGALVHLLD 656
E+A++ +EAA + AA VP+EP GD + G A+++LL
Sbjct: 74 EDARKEREAAVAAAAAAVPSEP----------------GDPLEAVAFEEKEGKAVLNLLF 117
Query: 657 LPCVPPPPAPIPDLKVFEREGVQLNLSFIRPPENP 691
P P A +KVFE +++ RP + P
Sbjct: 118 SPRATKPSALSRAVKVFETFEAKIHHLETRPAQRP 152
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,448,855
Number of Sequences: 37866
Number of extensions: 1390377
Number of successful extensions: 5576
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 5424
Number of HSP's gapped (non-prelim): 164
length of query: 785
length of database: 18,247,518
effective HSP length: 110
effective length of query: 675
effective length of database: 14,082,258
effective search space: 9505524150
effective search space used: 9505524150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.