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Search of human proteins with 4503627
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503627 coagulation factor XI precursor [Homo sapiens]
(625 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503627 coagulation factor XI precursor [Homo sapiens] 1316 0.0
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 793 0.0
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 203 3e-52
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 203 3e-52
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 201 2e-51
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 197 3e-50
gi|223942069 enterokinase precursor [Homo sapiens] 196 7e-50
gi|4506153 prostasin preproprotein [Homo sapiens] 194 2e-49
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 192 6e-49
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 190 4e-48
gi|33695155 hepsin [Homo sapiens] 186 4e-47
gi|4504481 hepsin [Homo sapiens] 186 4e-47
gi|13994276 marapsin [Homo sapiens] 186 4e-47
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 184 2e-46
gi|194018492 transmembrane protease, serine 11F [Homo sapiens] 184 3e-46
gi|110578663 hypothetical protein LOC203074 [Homo sapiens] 183 4e-46
gi|5803197 testisin isoform 1 [Homo sapiens] 183 5e-46
gi|21614531 testisin isoform 2 [Homo sapiens] 182 6e-46
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens] 182 8e-46
gi|11545839 protease, serine, 22 [Homo sapiens] 182 1e-45
gi|34098976 marapsin 2 [Homo sapiens] 181 2e-45
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 180 3e-45
gi|29244926 corin [Homo sapiens] 179 7e-45
gi|68508970 tryptase beta 2 precursor [Homo sapiens] 179 7e-45
gi|4506143 neurotrypsin precursor [Homo sapiens] 178 1e-44
gi|11415040 matriptase [Homo sapiens] 176 8e-44
gi|117956391 protease, serine, 33 [Homo sapiens] 176 8e-44
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] 174 2e-43
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ... 174 2e-43
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ... 174 2e-43
>gi|4503627 coagulation factor XI precursor [Homo sapiens]
Length = 625
Score = 1316 bits (3405), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT 60
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
Sbjct: 1 MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT 60
Query: 61 FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM 120
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
Sbjct: 61 FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM 120
Query: 121 KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK 180
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
Sbjct: 121 KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK 180
Query: 181 LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT 240
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
Sbjct: 181 LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT 240
Query: 241 FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD 300
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
Sbjct: 241 FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD 300
Query: 301 FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL 360
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
Sbjct: 301 FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL 360
Query: 361 HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI 420
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
Sbjct: 361 HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI 420
Query: 421 IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD 480
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
Sbjct: 421 IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD 480
Query: 481 IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV 540
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
Sbjct: 481 IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV 540
Query: 541 TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA 600
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
Sbjct: 541 TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA 600
Query: 601 QRERPGVYTNVVEYVDWILEKTQAV 625
QRERPGVYTNVVEYVDWILEKTQAV
Sbjct: 601 QRERPGVYTNVVEYVDWILEKTQAV 625
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 793 bits (2047), Expect = 0.0
Identities = 367/627 (58%), Positives = 465/627 (74%), Gaps = 3/627 (0%)
Query: 1 MIFLYQVVHFI-LFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLF 59
MI Q +FI LF +VS C+TQL ++ F GGD+ +++TP+A+YCQ+ CT+HPRCLLF
Sbjct: 1 MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF 60
Query: 60 TFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLD 119
+F S D + F C LKDSVT TLP+V+RT A+SG+S KQC HQISAC++DIY +D
Sbjct: 61 SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD 120
Query: 120 MKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRIT 179
M+G+N+N S S +ECQ+RCT ++ C FF+YAT+ F E+RN CLLK++ GTPT I
Sbjct: 121 MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK 180
Query: 180 KLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFF 239
L V SGFSLK CALS + C +IF + F+D ++ V+ PDAFVC ICT+HP CLFF
Sbjct: 181 VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF 240
Query: 240 TFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDT 299
TF++ W ESQRN+CLLKTSESG PS+ + +SG+SL +C+ ++P CHS Y
Sbjct: 241 TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV 300
Query: 300 DFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKI 359
DF GEEL++ K CQ+ CT +RCQFFTY+ C E K KC+L+LS +GSPT+I
Sbjct: 301 DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI 360
Query: 360 LHGRGGISGYTLRLCKM-DNE-CTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCG 417
+G G SGY+LRLC DN CTTK RIVGGT S GEWPWQV+L QRHLCG
Sbjct: 361 AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG 420
Query: 418 GSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAES 477
GS+IG+QW+LTAAHCF G+ + R+YSGILN S+I +DT F ++EIIIH YK++E
Sbjct: 421 GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG 480
Query: 478 GYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI 537
+DIAL+KL+ +NYT+ Q+PICLPSKGD + IYT+CWVTGWG+ K + +IQN LQK I
Sbjct: 481 NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI 540
Query: 538 PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGE 597
PLVTNEECQKRY+ +KIT +M+CAGY+EGGKDACKGDSGGPL CKHN +W LVGITSWGE
Sbjct: 541 PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE 600
Query: 598 GCAQRERPGVYTNVVEYVDWILEKTQA 624
GCA+RE+PGVYT V EY+DWILEKTQ+
Sbjct: 601 GCARREQPGVYTKVAEYMDWILEKTQS 627
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 203 bits (517), Expect = 3e-52
Identities = 103/244 (42%), Positives = 146/244 (59%), Gaps = 14/244 (5%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG-VESPKILRVY 445
RIVGG +++ G WPWQV+LH + H+CGGSII +WI+TAAHC + +P +
Sbjct: 292 RIVGGESALPGAWPWQVSLHVQNV---HVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAF 348
Query: 446 SGILNQSEIKEDTSFFG----VQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICL 501
+GIL QS + F+G V+++I H Y DIAL+KL+ + + D +P+CL
Sbjct: 349 AGILRQSFM-----FYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCL 403
Query: 502 PSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRY-RGHKITHKMIC 560
P+ G CW++GWG + + K L AK+ L+ + C RY + IT MIC
Sbjct: 404 PNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMIC 463
Query: 561 AGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILE 620
AG+ +G D+C+GDSGGPL N +W L+G TSWG GCA+ RPGVY NV+ + DWI
Sbjct: 464 AGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYR 523
Query: 621 KTQA 624
+ +A
Sbjct: 524 QMRA 527
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 203 bits (517), Expect = 3e-52
Identities = 103/244 (42%), Positives = 146/244 (59%), Gaps = 14/244 (5%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG-VESPKILRVY 445
RIVGG +++ G WPWQV+LH + H+CGGSII +WI+TAAHC + +P +
Sbjct: 255 RIVGGESALPGAWPWQVSLHVQNV---HVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAF 311
Query: 446 SGILNQSEIKEDTSFFG----VQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICL 501
+GIL QS + F+G V+++I H Y DIAL+KL+ + + D +P+CL
Sbjct: 312 AGILRQSFM-----FYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCL 366
Query: 502 PSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRY-RGHKITHKMIC 560
P+ G CW++GWG + + K L AK+ L+ + C RY + IT MIC
Sbjct: 367 PNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMIC 426
Query: 561 AGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILE 620
AG+ +G D+C+GDSGGPL N +W L+G TSWG GCA+ RPGVY NV+ + DWI
Sbjct: 427 AGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYR 486
Query: 621 KTQA 624
+ +A
Sbjct: 487 QMRA 490
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 201 bits (510), Expect = 2e-51
Identities = 103/244 (42%), Positives = 148/244 (60%), Gaps = 14/244 (5%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL---R 443
RIVGG + +WPWQV+LH + H+CGG++I QW+LTAAHCF+ V K+L +
Sbjct: 325 RIVGGALASDSKWPWQVSLHFGTT---HICGGTLIDAQWVLTAAHCFF-VTREKVLEGWK 380
Query: 444 VYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPS 503
VY+G N ++ E S + EIII+ Y E YDIAL++L + + P CLP
Sbjct: 381 VYAGTSNLHQLPEAAS---IAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPM 437
Query: 504 KGDRNVIYTDCWVTGWGY-RKLRDKIQNTLQKAKIPLVTNEECQKR--YRGHKITHKMIC 560
G + CW+TG+G R+ DK L++ ++ L+ ++C Y + +T +M+C
Sbjct: 438 HGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSY-LTPRMMC 496
Query: 561 AGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILE 620
AG GG+D+C+GDSGGPL C+ N W+L G+TSWG GC QR +PGVYT V E + WI
Sbjct: 497 AGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYS 556
Query: 621 KTQA 624
K ++
Sbjct: 557 KMES 560
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 197 bits (500), Expect = 3e-50
Identities = 97/252 (38%), Positives = 146/252 (57%), Gaps = 11/252 (4%)
Query: 378 NECTTK-IKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGV 436
+EC + + RIVGG + G WPWQ ++ RH CGGS++ +W++TAAHC +
Sbjct: 207 SECGARPLASRIVGGQSVAPGRWPWQASVALGF---RHTCGGSVLAPRWVVTAAHCMHSF 263
Query: 437 ESPKIL--RVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTD 494
++ RV++G+++ S ++ V+ II H Y YD+ALL+L+T +N++D
Sbjct: 264 RLARLSSWRVHAGLVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNFSD 322
Query: 495 SQRPICLPSKGDRNVIYTDCWVTGWGY-RKLRDKIQNTLQKAKIPLVTNEECQKR--YRG 551
+ +CLP+K + CWV+GWG+ + LQ +PL + + C Y G
Sbjct: 323 TVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSG 382
Query: 552 HKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNV 611
+T +M+CAGY +G DAC+GDSGGPL C + W LVG+ SWG GCA+ PGVY V
Sbjct: 383 -ALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKV 441
Query: 612 VEYVDWILEKTQ 623
E++DWI + Q
Sbjct: 442 AEFLDWIHDTAQ 453
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 196 bits (497), Expect = 7e-50
Identities = 98/237 (41%), Positives = 136/237 (57%), Gaps = 5/237 (2%)
Query: 384 IKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG--VESPKI 441
I P+IVGG+ + G WPW V L+ R LCG S++ + W+++AAHC YG +E K
Sbjct: 781 ITPKIVGGSNAKEGAWPWVVGLYYGG---RLLCGASLVSSDWLVSAAHCVYGRNLEPSKW 837
Query: 442 LRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICL 501
+ + + T + EI+I+ Y DIA++ LE VNYTD +PICL
Sbjct: 838 TAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICL 897
Query: 502 PSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICA 561
P + +C + GWG + N LQ+A +PL++NE CQ++ + IT MICA
Sbjct: 898 PEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICA 957
Query: 562 GYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618
GY EGG D+C+GDSGGPL C+ N W L G+TS+G CA RPGVY V + +WI
Sbjct: 958 GYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 194 bits (494), Expect = 2e-49
Identities = 100/251 (39%), Positives = 134/251 (53%), Gaps = 12/251 (4%)
Query: 380 CTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESP 439
C + RI GG+++V G+WPWQV++ H+CGGS++ QW+L+AAHCF
Sbjct: 37 CGVAPQARITGGSSAVAGQWPWQVSITYEGV---HVCGGSLVSEQWVLSAAHCFPSEHHK 93
Query: 440 KILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPI 499
+ V G ED +++II H Y S DIALL+L + ++ RPI
Sbjct: 94 EAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPI 153
Query: 500 CLPSKGDRNVIYTDCWVTGWGYRKLRDKI--QNTLQKAKIPLVTNEECQKRYR------- 550
CLP+ C VTGWG+ + LQ+ ++PL++ E C Y
Sbjct: 154 CLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEE 213
Query: 551 GHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTN 610
H + M+CAGY EGGKDAC+GDSGGPLSC +W+L GI SWG+ C R RPGVYT
Sbjct: 214 PHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTL 273
Query: 611 VVEYVDWILEK 621
Y WI K
Sbjct: 274 ASSYASWIQSK 284
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 192 bits (489), Expect = 6e-49
Identities = 95/235 (40%), Positives = 139/235 (59%), Gaps = 7/235 (2%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFY--GVESPKILRV 444
RIVGG S GEWPWQ +L RH+CGG++I ++W++TAAHCF + S + V
Sbjct: 576 RIVGGAVSSEGEWPWQASLQVRG---RHICGGALIADRWVITAAHCFQEDSMASTVLWTV 632
Query: 445 YSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSK 504
+ G + Q+ F V +++H ++ YD+ALL+L+ V + + RP+CLP++
Sbjct: 633 FLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPAR 692
Query: 505 GDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYR 564
CW+TGWG + I N LQK + L+ + C + YR +++T +M+CAGYR
Sbjct: 693 SHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYR-YQVTPRMLCAGYR 751
Query: 565 EGGKDACKGDSGGPLSCKH-NEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618
+G KDAC+GDSGGPL CK + W L G+ SWG GC + GVYT + + WI
Sbjct: 752 KGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWI 806
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 190 bits (482), Expect = 4e-48
Identities = 96/239 (40%), Positives = 139/239 (58%), Gaps = 7/239 (2%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446
RIVGG S+ +WPWQ +L HLCGGS+I WI+TAAHC Y + PK +
Sbjct: 216 RIVGGNMSLLSQWPWQASLQFQG---YHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQV 272
Query: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 506
G+++ + + V++I+ H +YK G DIAL+KL + + + +P+CLP+ +
Sbjct: 273 GLVSLLDNPAPSHL--VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEE 330
Query: 507 RNVIYTDCWVTGWGYRKL-RDKIQNTLQKAKIPLVTNEECQKR-YRGHKITHKMICAGYR 564
CW +GWG + L A +PL++N+ C R G I+ M+CAGY
Sbjct: 331 NFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYL 390
Query: 565 EGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ 623
GG D+C+GDSGGPL C+ +W LVG TS+G GCA+ +PGVYT V ++DWI E+ +
Sbjct: 391 TGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQME 449
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 186 bits (473), Expect = 4e-47
Identities = 101/248 (40%), Positives = 142/248 (57%), Gaps = 21/248 (8%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL---R 443
RIVGG + G WPWQV+L HLCGGS++ W+LTAAHCF E ++L R
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGA---HLCGGSLLSGDWVLTAAHCF--PERNRVLSRWR 216
Query: 444 VYSGILNQSEIKEDTSFFGVQEIIIHDQY------KMAESGYDIALLKLETTVNYTDSQR 497
V++G + Q+ GVQ ++ H Y E+ DIAL+ L + + T+ +
Sbjct: 217 VFAGAVAQAS--PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQ 274
Query: 498 PICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQ-KRYRGHKITH 556
P+CLP+ G V C VTGWG + + LQ+A++P+++N+ C + G++I
Sbjct: 275 PVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKP 334
Query: 557 KMICAGYREGGKDACKGDSGGPLSCK----HNEVWHLVGITSWGEGCAQRERPGVYTNVV 612
KM CAGY EGG DAC+GDSGGP C+ W L GI SWG GCA ++PGVYT V
Sbjct: 335 KMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVS 394
Query: 613 EYVDWILE 620
++ +WI +
Sbjct: 395 DFREWIFQ 402
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 186 bits (473), Expect = 4e-47
Identities = 101/248 (40%), Positives = 142/248 (57%), Gaps = 21/248 (8%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL---R 443
RIVGG + G WPWQV+L HLCGGS++ W+LTAAHCF E ++L R
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGA---HLCGGSLLSGDWVLTAAHCF--PERNRVLSRWR 216
Query: 444 VYSGILNQSEIKEDTSFFGVQEIIIHDQY------KMAESGYDIALLKLETTVNYTDSQR 497
V++G + Q+ GVQ ++ H Y E+ DIAL+ L + + T+ +
Sbjct: 217 VFAGAVAQAS--PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQ 274
Query: 498 PICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQ-KRYRGHKITH 556
P+CLP+ G V C VTGWG + + LQ+A++P+++N+ C + G++I
Sbjct: 275 PVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKP 334
Query: 557 KMICAGYREGGKDACKGDSGGPLSCK----HNEVWHLVGITSWGEGCAQRERPGVYTNVV 612
KM CAGY EGG DAC+GDSGGP C+ W L GI SWG GCA ++PGVYT V
Sbjct: 335 KMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVS 394
Query: 613 EYVDWILE 620
++ +WI +
Sbjct: 395 DFREWIFQ 402
>gi|13994276 marapsin [Homo sapiens]
Length = 290
Score = 186 bits (473), Expect = 4e-47
Identities = 96/245 (39%), Positives = 136/245 (55%), Gaps = 19/245 (7%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446
R+VGG + GEWPWQV++ H CGGS+I QW+LTAAHCF + +V
Sbjct: 34 RMVGGQDTQEGEWPWQVSIQRNGS---HFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLL 90
Query: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 506
G + + V+++ + Y+ S D+AL++LE V +T+ P+CLP D
Sbjct: 91 GARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLP---D 147
Query: 507 RNVIYT---DCWVTGWGYRKLRDKIQNT--LQKAKIPLVTNEEC--------QKRYRGHK 553
+VI+ +CWVTGWG D + LQK +P++ +C + Y+
Sbjct: 148 PSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKT 207
Query: 554 ITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVE 613
I + M+CAG+ EG KDACKGDSGGPL C + W G+ SWGEGCA++ RPGVY V
Sbjct: 208 IKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTA 267
Query: 614 YVDWI 618
+ +WI
Sbjct: 268 HHNWI 272
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 184 bits (467), Expect = 2e-46
Identities = 100/263 (38%), Positives = 147/263 (55%), Gaps = 19/263 (7%)
Query: 367 SGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWI 426
+ + + C + T + RI+GGT + G WPWQV+L + H CGGS+I N WI
Sbjct: 166 ANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNA---HHCGGSLINNMWI 222
Query: 427 LTAAHCFYGVESPKILRVYSGILNQSEIKEDTSF----FGVQEIIIHDQYKMAESGYDIA 482
LTAAHCF +P+ SGI T+F V+ I+IH+ YK A DIA
Sbjct: 223 LTAAHCFRSNSNPRDWIATSGI--------STTFPKLRMRVRNILIHNNYKSATHENDIA 274
Query: 483 LLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTN 542
L++LE +V +T +CLP+ + +VTGWG ++ L++ ++ +++N
Sbjct: 275 LVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISN 334
Query: 543 EECQ--KRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHN-EVWHLVGITSWGEGC 599
+ C Y G I M+CAG +GG DAC+GDSGGPL + + +W +VGI SWG+ C
Sbjct: 335 DVCNAPHSYNG-AILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQC 393
Query: 600 AQRERPGVYTNVVEYVDWILEKT 622
++PGVYT V Y+DWI ++T
Sbjct: 394 GLPDKPGVYTRVTAYLDWIRQQT 416
>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
Length = 438
Score = 184 bits (466), Expect = 3e-46
Identities = 99/267 (37%), Positives = 155/267 (58%), Gaps = 14/267 (5%)
Query: 359 ILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGG 418
+L+ R GI + + + T +I + G ++ GEWPWQ +L H CG
Sbjct: 181 LLNSRCGIRMTSSNMPLPASSSTQRI---VQGRETAMEGEWPWQASLQLIG--SGHQCGA 235
Query: 419 SIIGNQWILTAAHCFYGVESP-KILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAES 477
S+I N W+LTAAHCF+ + P + + + + +K + V++II+H+ Y +
Sbjct: 236 SLISNTWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRN-----VRKIILHENYHRETN 290
Query: 478 GYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI 537
DIAL++L T V +++ + +CLP + T +VTG+G IQNTL++A++
Sbjct: 291 ENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARV 350
Query: 538 PLVTNEECQKR--YRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSW 595
++ + C ++ Y G IT M+CAG+ EG DACKGDSGGPL ++++W++VGI SW
Sbjct: 351 ETISTDVCNRKDVYDG-LITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSW 409
Query: 596 GEGCAQRERPGVYTNVVEYVDWILEKT 622
G+ CA ++PGVYT V +Y DWI KT
Sbjct: 410 GQSCALPKKPGVYTRVTKYRDWIASKT 436
>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
Length = 352
Score = 183 bits (465), Expect = 4e-46
Identities = 105/246 (42%), Positives = 140/246 (56%), Gaps = 21/246 (8%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVES-PKILRVY 445
RI GG + GE+PWQV++ S CGGSI+ WILTAAHC Y E P+ L V
Sbjct: 67 RITGGMEAEVGEFPWQVSIQARSEP---FCGGSILNKWWILTAAHCLYSEELFPEELSVV 123
Query: 446 SGILNQS----EIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICL 501
G + + EIKE V II+H +K A DIALL L + + D + PICL
Sbjct: 124 LGTNDLTSPSMEIKE------VASIILHKDFKRANMDNDIALLLLASPIKLDDLKVPICL 177
Query: 502 PSKGDRNVIYTDCWVTGWGYRKLRDK--IQNTLQKAKIPLVTNEECQKRYRGHKITHKMI 559
P++ + +CWV GWG DK ++ L KA + ++ EEC K + K+T M+
Sbjct: 178 PTQPGP-ATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIMDWEECSKMFP--KLTKNML 234
Query: 560 CAGYREGGKDACKGDSGGPLSC--KHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDW 617
CAGY+ DACKGDSGGPL C + E W+ VGI SWG+ C ++ PG+YT++V Y W
Sbjct: 235 CAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIISWGKSCGEKNTPGIYTSLVNYNLW 294
Query: 618 ILEKTQ 623
I + TQ
Sbjct: 295 IEKVTQ 300
>gi|5803197 testisin isoform 1 [Homo sapiens]
Length = 314
Score = 183 bits (464), Expect = 5e-46
Identities = 101/251 (40%), Positives = 141/251 (56%), Gaps = 23/251 (9%)
Query: 384 IKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILR 443
I RIVGG + G WPWQ +L H+CG S++ ++W LTAAHCF E+ L
Sbjct: 38 ITSRIVGGEDAELGRWPWQGSLRLWDS---HVCGVSLLSHRWALTAAHCF---ETYSDLS 91
Query: 444 VYSGILNQ-SEIKEDTSFFGVQ---------EIIIHDQYKMAESGYDIALLKLETTVNYT 493
SG + Q ++ SF+ +Q I + +Y + S YDIAL+KL V YT
Sbjct: 92 DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYT 150
Query: 494 DSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQN--TLQKAKIPLVTNEECQKRYRG 551
+PICL + TDCWVTGWGY K + + + TLQ+ ++ ++ N C +
Sbjct: 151 KHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK 210
Query: 552 HK----ITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGV 607
+ I M+CAG +GGKDAC GDSGGPL+C N +W+ +G+ SWG GC + RPGV
Sbjct: 211 YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGV 270
Query: 608 YTNVVEYVDWI 618
YTN+ + +WI
Sbjct: 271 YTNISHHFEWI 281
>gi|21614531 testisin isoform 2 [Homo sapiens]
Length = 312
Score = 182 bits (463), Expect = 6e-46
Identities = 98/246 (39%), Positives = 137/246 (55%), Gaps = 15/246 (6%)
Query: 384 IKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFY-GVESPKIL 442
I RIVGG + G WPWQ +L H+CG S++ ++W LTAAHCF + P
Sbjct: 38 ITSRIVGGEDAELGRWPWQGSLRLWDS---HVCGVSLLSHRWALTAAHCFETDLSDPSGW 94
Query: 443 RVYSGILNQS----EIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRP 498
V G L ++ + + V I + +Y + S YDIAL+KL V YT +P
Sbjct: 95 MVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY-LGNSPYDIALVKLSAPVTYTKHIQP 153
Query: 499 ICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQN--TLQKAKIPLVTNEECQKRYRGHK--- 553
ICL + TDCWVTGWGY K + + + TLQ+ ++ ++ N C + +
Sbjct: 154 ICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRK 213
Query: 554 -ITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVV 612
I M+CAG +GGKDAC GDSGGPL+C N +W+ +G+ SWG GC + RPGVYTN+
Sbjct: 214 DIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNIS 273
Query: 613 EYVDWI 618
+ +WI
Sbjct: 274 HHFEWI 279
>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
Length = 275
Score = 182 bits (462), Expect = 8e-46
Identities = 99/242 (40%), Positives = 130/242 (53%), Gaps = 16/242 (6%)
Query: 388 IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFY-GVESPKILRVYS 446
IVGG + R +WPWQV+L P H CGGS+I QW+LTAAHC V+ LRV
Sbjct: 31 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQ- 89
Query: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 506
L + + V II+H Q+ A+ G DIALL+LE VN + + LP +
Sbjct: 90 --LREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASE 147
Query: 507 RNVIYTDCWVTGWGYRKLRDKIQNT--LQKAKIPLVTNEECQKRYRGHKIT--------H 556
CWVTGWG +++ L++ K+P++ N C +Y T
Sbjct: 148 TFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRD 207
Query: 557 KMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVD 616
M+CAG +D+C+GDSGGPL CK N W G+ SWGEGCAQ RPG+YT V Y+D
Sbjct: 208 DMLCAGNTR--RDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLD 265
Query: 617 WI 618
WI
Sbjct: 266 WI 267
>gi|11545839 protease, serine, 22 [Homo sapiens]
Length = 317
Score = 182 bits (461), Expect = 1e-45
Identities = 98/249 (39%), Positives = 137/249 (55%), Gaps = 15/249 (6%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFY-GVESPKILRVY 445
R+VGG S EWPW V++ H C GS++ ++W++TAAHCF + P + V
Sbjct: 49 RVVGGEDSTDSEWPWIVSIQKNGT---HHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVL 105
Query: 446 SGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGY-DIALLKLETTVNYTDSQRPICLPSK 504
G + GV + H Y E DIAL++LE ++ +++ PICLP
Sbjct: 106 LGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDA 165
Query: 505 GDRNVIYTDCWVTGWGYRKLRDKIQ----NTLQKAKIPLVTNEECQKRY-RGH---KITH 556
T CW++GWG ++D + TLQK K+P++ +E C Y RG IT
Sbjct: 166 SIHLPPNTHCWISGWG--SIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITE 223
Query: 557 KMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVD 616
M+CAGY EG +DAC GDSGGPL C+ + W L GI SWGEGCA+R RPGVY ++ +
Sbjct: 224 DMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRS 283
Query: 617 WILEKTQAV 625
W+ + Q V
Sbjct: 284 WVEKIVQGV 292
>gi|34098976 marapsin 2 [Homo sapiens]
Length = 326
Score = 181 bits (459), Expect = 2e-45
Identities = 89/240 (37%), Positives = 139/240 (57%), Gaps = 8/240 (3%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446
+I+GG + +WPWQV++H H+CGGSI+ W+L+AAHCF+ ++ KI +Y
Sbjct: 59 KILGGVPAPERKWPWQVSVHYAG---LHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYV 115
Query: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAES-GYDIALLKLETTVNYTDSQRPICLPSKG 505
G++N T ++ V +I+H Y+M G D+AL++L+T + +++S P+CL +
Sbjct: 116 GLVNLRVAGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATP- 174
Query: 506 DRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHK--ITHKMICAGY 563
+ N+ +CW TGWG + + + LQ+ ++PL+ C Y GH I M+CAG
Sbjct: 175 EVNLTSANCWATGWGLVSKQGETSDELQEMQLPLILEPWCHLLY-GHMSYIMPDMLCAGD 233
Query: 564 REGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ 623
K C+GDSGGPL C+ N W +GI SWG GC+ PGVY +V + WI + +
Sbjct: 234 ILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIE 293
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 180 bits (457), Expect = 3e-45
Identities = 102/239 (42%), Positives = 132/239 (55%), Gaps = 15/239 (6%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG--VESPKILRV 444
RI+GGT ++ G WPWQV+LH CG S+I +W+L+AAHCF+G + P
Sbjct: 479 RIIGGTDTLEGGWPWQVSLHFVGSAY---CGASVISREWLLSAAHCFHGNRLSDPTPWTA 535
Query: 445 YSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQ--RPICLP 502
+ G+ Q K + V+ I++H+ Y YDIALL+L T Q +PIC+P
Sbjct: 536 HLGMYVQGNAKFVSP---VRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIP 592
Query: 503 SKGDRNVIYTDCWVTGWGYRKLRD-KIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICA 561
G R CWVTGWG R D K LQ+A++ L+ C Y IT +M+CA
Sbjct: 593 PTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYG--IITSRMLCA 650
Query: 562 GYREGGKDACKGDSGGPLSC--KHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618
G G +DACKGDSGGPLSC K + W L GI SWG G + PGVYT V +V WI
Sbjct: 651 GIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWI 709
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 179 bits (454), Expect = 7e-45
Identities = 96/240 (40%), Positives = 140/240 (58%), Gaps = 10/240 (4%)
Query: 383 KIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL 442
++ RI+GG S G WPWQ +L S H+CG +I +W+LT AHCF G E+ +
Sbjct: 797 RMNKRILGGRTSRPGRWPWQCSLQ--SEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVW 854
Query: 443 RVYSGI--LNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPIC 500
+V GI L+ + T F V+ II+H +Y A YDI++++L ++ T RP+C
Sbjct: 855 KVVLGINNLDHPSVFMQTRF--VKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVC 912
Query: 501 LPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMIC 560
LP+ T C++TGWG+ + +K+ LQ+ ++ +++ E CQ + IT +MIC
Sbjct: 913 LPNPEQWLEPDTYCYITGWGH--MGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMIC 970
Query: 561 AGYREGGKDACKGDSGGPLSC-KHNEVWHLVGITSWGEGCAQRE-RPGVYTNVVEYVDWI 618
AGY G D+C GDSGGPL C K W L G+TSWG C + PGVY+NV +V+WI
Sbjct: 971 AGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWI 1030
>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
Length = 275
Score = 179 bits (454), Expect = 7e-45
Identities = 98/242 (40%), Positives = 129/242 (53%), Gaps = 16/242 (6%)
Query: 388 IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFY-GVESPKILRVYS 446
IVGG + R +WPWQV+L H CGGS+I QW+LTAAHC V+ LRV
Sbjct: 31 IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQ- 89
Query: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 506
L + + V II+H Q+ A+ G DIALL+LE VN + + LP +
Sbjct: 90 --LREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASE 147
Query: 507 RNVIYTDCWVTGWGYRKLRDKIQNT--LQKAKIPLVTNEECQKRYRGHKIT--------H 556
CWVTGWG +++ L++ K+P++ N C +Y T
Sbjct: 148 TFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRD 207
Query: 557 KMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVD 616
M+CAG +D+C+GDSGGPL CK N W G+ SWGEGCAQ RPG+YT V Y+D
Sbjct: 208 DMLCAGNTR--RDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLD 265
Query: 617 WI 618
WI
Sbjct: 266 WI 267
>gi|4506143 neurotrypsin precursor [Homo sapiens]
Length = 875
Score = 178 bits (452), Expect = 1e-44
Identities = 103/249 (41%), Positives = 144/249 (57%), Gaps = 16/249 (6%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSP--TQRHLCGGSIIGNQWILTAAHCF--YGVESPKIL 442
RI+GG S+RG WPWQV+L S R LCG +++ + W+LTAAHCF YG S +
Sbjct: 630 RIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYG-NSTRSY 688
Query: 443 RVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKL----ETTVNYTDSQRP 498
V G + +E GVQ+I+IH +Y+ S YDIAL++L E ++ P
Sbjct: 689 AVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLP 748
Query: 499 ICLPSKGDR-NVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHK 557
CLP +R ++C++TGWG TLQ+A IPL+ C++RY+G + T +
Sbjct: 749 ACLPLWRERPQKTASNCYITGWG--DTGRAYSRTLQQAAIPLLPKRFCEERYKG-RFTGR 805
Query: 558 MICAGYREGGK--DACKGDSGGPLSCKH-NEVWHLVGITSWGEGCAQRERPGVYTNVVEY 614
M+CAG K D+C+GDSGGPL C+ E W + G+TSWG GC ++ PGVYT V +
Sbjct: 806 MLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAF 865
Query: 615 VDWILEKTQ 623
V WI T+
Sbjct: 866 VPWIKSVTK 874
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 176 bits (445), Expect = 8e-44
Identities = 116/320 (36%), Positives = 160/320 (50%), Gaps = 37/320 (11%)
Query: 316 ACQKLCTNAVRCQFFTYTPAQASC-NEGKGKCYLKLS-SNGSPTKILHGRGGISGYTLRL 373
+C K+ N V C TY C ++G +C K S+GS K G+ +T +
Sbjct: 558 SCPKV--NVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC--GLRSFTRQA 613
Query: 374 CKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCF 433
R+VGGT + GEWPWQV+LH Q H+CG S+I W+++AAHC+
Sbjct: 614 -------------RVVGGTDADEGEWPWQVSLHALG--QGHICGASLISPNWLVSAAHCY 658
Query: 434 -----YGVESPKILRVYSGILNQSEIKEDTSFFGVQE-----IIIHDQYKMAESGYDIAL 483
+ P + G+ +QS+ S GVQE II H + YDIAL
Sbjct: 659 IDDRGFRYSDPTQWTAFLGLHDQSQ----RSAPGVQERRLKRIISHPFFNDFTFDYDIAL 714
Query: 484 LKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNE 543
L+LE Y+ RPICLP WVTGWG+ + LQK +I ++
Sbjct: 715 LELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQT 774
Query: 544 ECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHL-VGITSWGEGCAQR 602
C+ +IT +M+C G+ GG D+C+GDSGGPLS + G+ SWG+GCAQR
Sbjct: 775 TCENLLP-QQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQR 833
Query: 603 ERPGVYTNVVEYVDWILEKT 622
+PGVYT + + DWI E T
Sbjct: 834 NKPGVYTRLPLFRDWIKENT 853
>gi|117956391 protease, serine, 33 [Homo sapiens]
Length = 280
Score = 176 bits (445), Expect = 8e-44
Identities = 98/248 (39%), Positives = 129/248 (52%), Gaps = 17/248 (6%)
Query: 383 KIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL 442
++ RIVGG GEWPWQ ++ H+CGGS+I QW+LTAAHCF P
Sbjct: 32 RMSSRIVGGRDGRDGEWPWQASIQHRGA---HVCGGSLIAPQWVLTAAHCFPRRALPAEY 88
Query: 443 RVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLP 502
RV G L T V+ +++ Y + D+ALL+L V + +P+CLP
Sbjct: 89 RVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVCLP 148
Query: 503 SKGDRNVIYTDCWVTGWGYRKLRDKIQ----NTLQKAKIPLVTNEECQKRYR-------- 550
G R T C VTGWG LR + LQ ++PL+ + C Y
Sbjct: 149 VPGARPPPGTPCRVTGWG--SLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQA 206
Query: 551 GHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTN 610
+ +CAGY +G KDAC+GDSGGPL+C + W LVG+ SWG+GCA RPGVYT+
Sbjct: 207 ERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTS 266
Query: 611 VVEYVDWI 618
V Y WI
Sbjct: 267 VATYSPWI 274
>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
Length = 321
Score = 174 bits (442), Expect = 2e-43
Identities = 98/238 (41%), Positives = 132/238 (55%), Gaps = 15/238 (6%)
Query: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446
RIVGG A+ G WPWQ +L + H+CGGS++ QW+LTAAHCF G + +V+
Sbjct: 37 RIVGGHAAPAGAWPWQASLRLR---RVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHL 93
Query: 447 GILNQSEIKEDTSFFGVQEIIIHDQYK-MAESGYDIALLKLETTVNYTDSQRPICLPSKG 505
G L EI F V++II+H + DIAL++L V + P+CLP
Sbjct: 94 GEL---EITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEAS 150
Query: 506 DRNVIYTDCWVTGWGYRKLRDKIQN--TLQKAKIPLVTNEECQKRYRGHK---ITHKMIC 560
D CWVTGWGY + + + +L++ K+ +V E C++ Y G + M+C
Sbjct: 151 DDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLC 210
Query: 561 AGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWI 618
A G DAC+ DSGGPL C+ N W GI SWGEGC + RPGVYT V YV+WI
Sbjct: 211 A---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWI 265
>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
sapiens]
Length = 418
Score = 174 bits (441), Expect = 2e-43
Identities = 92/250 (36%), Positives = 142/250 (56%), Gaps = 15/250 (6%)
Query: 380 CTTKIKP----RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG 435
C ++ P RI G + + WPWQ +L + H CG ++I N W++TAAHCF
Sbjct: 175 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNI---HQCGATLISNTWLVTAAHCFQK 231
Query: 436 VESPKILRVYSGI-LNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTD 494
++P V G +N +K + V+ IIH++Y+ A YDIA++++ + V ++D
Sbjct: 232 YKNPHQWTVSFGTKINPPLMKRN-----VRRFIIHEKYRSAAREYDIAVVQVSSRVTFSD 286
Query: 495 SQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEEC-QKRYRGHK 553
R ICLP +TG+G + QN L++A++ +++++ C Q + G+
Sbjct: 287 DIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGND 346
Query: 554 ITHKMICAGYREGGKDACKGDSGGPLSCKH-NEVWHLVGITSWGEGCAQRERPGVYTNVV 612
I M CAGY EG DAC+GDSGGPL + + W+L+GI SWG+ C Q+++PGVYT V
Sbjct: 347 IKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVT 406
Query: 613 EYVDWILEKT 622
Y +WI KT
Sbjct: 407 YYRNWIASKT 416
>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
sapiens]
Length = 421
Score = 174 bits (441), Expect = 2e-43
Identities = 92/250 (36%), Positives = 142/250 (56%), Gaps = 15/250 (6%)
Query: 380 CTTKIKP----RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYG 435
C ++ P RI G + + WPWQ +L + H CG ++I N W++TAAHCF
Sbjct: 178 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNI---HQCGATLISNTWLVTAAHCFQK 234
Query: 436 VESPKILRVYSGI-LNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTD 494
++P V G +N +K + V+ IIH++Y+ A YDIA++++ + V ++D
Sbjct: 235 YKNPHQWTVSFGTKINPPLMKRN-----VRRFIIHEKYRSAAREYDIAVVQVSSRVTFSD 289
Query: 495 SQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEEC-QKRYRGHK 553
R ICLP +TG+G + QN L++A++ +++++ C Q + G+
Sbjct: 290 DIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGND 349
Query: 554 ITHKMICAGYREGGKDACKGDSGGPLSCKH-NEVWHLVGITSWGEGCAQRERPGVYTNVV 612
I M CAGY EG DAC+GDSGGPL + + W+L+GI SWG+ C Q+++PGVYT V
Sbjct: 350 IKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVT 409
Query: 613 EYVDWILEKT 622
Y +WI KT
Sbjct: 410 YYRNWIASKT 419
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,850,796
Number of Sequences: 37866
Number of extensions: 1211013
Number of successful extensions: 2852
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2075
Number of HSP's gapped (non-prelim): 200
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.