Search of human proteins with 4503487

Search of human proteins with 4503487

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503487 ephrin-A5 [Homo sapiens]
         (228 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503487 ephrin-A5 [Homo sapiens]                                   479   e-136
gi|27894381 ephrin-A2 precursor [Homo sapiens]                        202   2e-52
gi|4826708 ephrin A3 [Homo sapiens]                                   159   1e-39
gi|33359682 ephrin A1 isoform a precursor [Homo sapiens]              151   4e-37
gi|33359680 ephrin A1 isoform b precursor [Homo sapiens]              143   1e-34
gi|4885197 ephrin A4 isoform a [Homo sapiens]                         142   2e-34
gi|100913200 ephrin A4 isoform c [Homo sapiens]                       140   1e-33
gi|33359686 ephrin A4 isoform b [Homo sapiens]                        140   1e-33
gi|4758250 ephrin B2 [Homo sapiens]                                    61   7e-10
gi|4503489 ephrin-B3 precursor [Homo sapiens]                          61   9e-10
gi|4758248 ephrin-B1 precursor [Homo sapiens]                          59   3e-09
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]    30   1.3  
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi...    30   1.3  
gi|7706326 splicing factor 3B, 14 kDa subunit [Homo sapiens]           30   1.3  
gi|6912338 dynein, axonemal, intermediate chain 1 [Homo sapiens]       29   2.9  
gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens]    28   5.0  

>gi|4503487 ephrin-A5 [Homo sapiens]
          Length = 228

 Score =  479 bits (1234), Expect = e-136
 Identities = 228/228 (100%), Positives = 228/228 (100%)

Query: 1   MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV 60
           MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV
Sbjct: 1   MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV 60

Query: 61  FCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQL 120
           FCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQL
Sbjct: 61  FCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQL 120

Query: 121 FTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDK 180
           FTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDK
Sbjct: 121 FTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDK 180

Query: 181 VENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 228
           VENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
Sbjct: 181 VENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 228


>gi|27894381 ephrin-A2 precursor [Homo sapiens]
          Length = 213

 Score =  202 bits (514), Expect = 2e-52
 Identities = 92/151 (60%), Positives = 115/151 (76%), Gaps = 7/151 (4%)

Query: 22  DPGSKAVADRYAVYWNSSNPRFQRG------DYHIDVCINDYLDVFCPHYEDSVPE-DKT 74
           +  ++A +DRYAVYWN SNPRF  G       Y ++V INDYLD++CPHY   +P  ++ 
Sbjct: 27  EDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERM 86

Query: 75  ERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGR 134
           E YVLYMVN +G+++CDH  +GFKRWECNRP +P GPLKFSEKFQLFTPFSLGFEFRPG 
Sbjct: 87  EHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGH 146

Query: 135 EYFYISSAIPDNGRRSCLKLKVFVRPTNSCM 165
           EY+YIS+  P+   R CL+LKV+VRPTN  +
Sbjct: 147 EYYYISATPPNAVDRPCLRLKVYVRPTNETL 177


>gi|4826708 ephrin A3 [Homo sapiens]
          Length = 238

 Score =  159 bits (403), Expect = 1e-39
 Identities = 80/161 (49%), Positives = 108/161 (67%), Gaps = 11/161 (6%)

Query: 6   MLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHY 65
           +L L+  V  + + +Q PG  A+ +R+AVYWNSSN   +R  Y + V +NDYLD++CPHY
Sbjct: 8   LLLLLVPVPLLPLLAQGPGG-ALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHY 66

Query: 66  EDSV--------PEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEK 117
             S         P    E+YVLYMV+ +GY  C+  S+GFKRWECNRPH+P+ P+KFSEK
Sbjct: 67  NSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCN-ASQGFKRWECNRPHAPHSPIKFSEK 125

Query: 118 FQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFV 158
           FQ ++ FSLG+EF  G EY+YIS+    N    CL++KVFV
Sbjct: 126 FQRYSAFSLGYEFHAGHEYYYISTP-THNLHWKCLRMKVFV 165


>gi|33359682 ephrin A1 isoform a precursor [Homo sapiens]
          Length = 205

 Score =  151 bits (382), Expect = 4e-37
 Identities = 73/135 (54%), Positives = 93/135 (68%), Gaps = 2/135 (1%)

Query: 25  SKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYED-SVPEDKTERYVLYMVN 83
           S A ADR+ V+WNSSNP+F+  DY I V +NDY+D+ CPHYED SV +   E+Y+LY+V 
Sbjct: 14  SLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVE 73

Query: 84  FDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAI 143
            + Y  C   SK   RW+CNRP + +GP K SEKFQ FTPF+LG EF+ G  Y+YIS  I
Sbjct: 74  HEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPI 133

Query: 144 PDNGRRSCLKLKVFV 158
             +  R CL+LKV V
Sbjct: 134 HQHEDR-CLRLKVTV 147


>gi|33359680 ephrin A1 isoform b precursor [Homo sapiens]
          Length = 183

 Score =  143 bits (361), Expect = 1e-34
 Identities = 65/117 (55%), Positives = 83/117 (70%), Gaps = 1/117 (0%)

Query: 25  SKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYED-SVPEDKTERYVLYMVN 83
           S A ADR+ V+WNSSNP+F+  DY I V +NDY+D+ CPHYED SV +   E+Y+LY+V 
Sbjct: 14  SLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVE 73

Query: 84  FDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYIS 140
            + Y  C   SK   RW+CNRP + +GP K SEKFQ FTPF+LG EF+ G  Y+YIS
Sbjct: 74  HEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYIS 130


>gi|4885197 ephrin A4 isoform a [Homo sapiens]
          Length = 201

 Score =  142 bits (358), Expect = 2e-34
 Identities = 88/226 (38%), Positives = 118/226 (52%), Gaps = 27/226 (11%)

Query: 4   VEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCP 63
           + +L L+  VLW   F   P     + R+ VYWNSSNPR  RGD  +++ +NDYLD+ CP
Sbjct: 1   MRLLPLLRTVLW-AAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCP 59

Query: 64  HYEDSVPEDKTERYVLYMVNFDGYSACD-HTSKGFKRWECNRPHSPNGPLKFSEKFQLFT 122
           HYE   P +  E + LYMV++ GY +C     + +KRW C+ P    G ++FSEK Q FT
Sbjct: 60  HYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFT 116

Query: 123 PFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVE 182
           PFSLGFEF PG  Y+YIS   P++  + CL+L+V V     C K               E
Sbjct: 117 PFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSV-----CCK---------------E 155

Query: 183 NSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL 228
              E A          + G     TP  P  LL +LL L+  LL +
Sbjct: 156 RKSESAHPVGSPGESGTSGWRGGDTPS-PLCLLLLLLLLILRLLRI 200


>gi|100913200 ephrin A4 isoform c [Homo sapiens]
          Length = 193

 Score =  140 bits (352), Expect = 1e-33
 Identities = 72/156 (46%), Positives = 98/156 (62%), Gaps = 6/156 (3%)

Query: 4   VEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCP 63
           + +L L+  VLW   F   P     + R+ VYWNSSNPR  RGD  +++ +NDYLD+ CP
Sbjct: 1   MRLLPLLRTVLW-AAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCP 59

Query: 64  HYEDSVPEDKTERYVLYMVNFDGYSACD-HTSKGFKRWECNRPHSPNGPLKFSEKFQLFT 122
           HYE   P +  E + LYMV++ GY +C     + +KRW C+ P    G ++FSEK Q FT
Sbjct: 60  HYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFT 116

Query: 123 PFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFV 158
           PFSLGFEF PG  Y+YIS   P++  + CL+L+V V
Sbjct: 117 PFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSV 151


>gi|33359686 ephrin A4 isoform b [Homo sapiens]
          Length = 207

 Score =  140 bits (352), Expect = 1e-33
 Identities = 72/156 (46%), Positives = 98/156 (62%), Gaps = 6/156 (3%)

Query: 4   VEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCP 63
           + +L L+  VLW   F   P     + R+ VYWNSSNPR  RGD  +++ +NDYLD+ CP
Sbjct: 1   MRLLPLLRTVLW-AAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCP 59

Query: 64  HYEDSVPEDKTERYVLYMVNFDGYSACD-HTSKGFKRWECNRPHSPNGPLKFSEKFQLFT 122
           HYE   P +  E + LYMV++ GY +C     + +KRW C+ P    G ++FSEK Q FT
Sbjct: 60  HYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFT 116

Query: 123 PFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFV 158
           PFSLGFEF PG  Y+YIS   P++  + CL+L+V V
Sbjct: 117 PFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSV 151


>gi|4758250 ephrin B2 [Homo sapiens]
          Length = 333

 Score = 61.2 bits (147), Expect = 7e-10
 Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 5/110 (4%)

Query: 34  VYWNSSNPRFQRGD-YHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDH 92
           +YWNSSN +F  G    +   I D LD+ CP   DS    + E Y +YMV+ D    C  
Sbjct: 33  IYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKV-DSKTVGQYEYYKVYMVDKDQADRCTI 91

Query: 93  TSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSA 142
             +      C +P      +KF+ KFQ F+P   G EF+  ++Y+ IS++
Sbjct: 92  KKENTPLLNCAKPDQD---IKFTIKFQEFSPNLWGLEFQKNKDYYIISTS 138


>gi|4503489 ephrin-B3 precursor [Homo sapiens]
          Length = 340

 Score = 60.8 bits (146), Expect = 9e-10
 Identities = 55/202 (27%), Positives = 85/202 (42%), Gaps = 24/202 (11%)

Query: 34  VYWNSSNPRFQ-RGDYHIDVCINDYLDVFCPHYEDSVPEDKT--ERYVLYMVNFDGYSAC 90
           VYWNS+N RFQ  G Y +   I D LD+ CP      P      E Y LY+V       C
Sbjct: 33  VYWNSANKRFQAEGGYVLYPQIGDRLDLLCPRARPPGPHSSPNYEFYKLYLVGGAQGRRC 92

Query: 91  DHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRS 150
           +          C+RP      L+F+ KFQ ++P   G EFR   +Y+ I+++   +G R 
Sbjct: 93  EAPPAPNLLLTCDRPDLD---LRFTIKFQEYSPNLWGHEFRSHHDYYIIATS---DGTRE 146

Query: 151 CLK-----------LKVFVR----PTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHES 195
            L+           +KV +R    P    +    V +   + +    +SLEP  + +   
Sbjct: 147 GLESLQGGVCLTRGMKVLLRVGQSPRGGAVPRKPVSEMPMERDRGAAHSLEPGKENLPGD 206

Query: 196 AEPSRGENAAQTPRIPSRLLAI 217
              +     A+ P  P  + A+
Sbjct: 207 PTSNATSRGAEGPLPPPSMPAV 228


>gi|4758248 ephrin-B1 precursor [Homo sapiens]
          Length = 346

 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 44/135 (32%), Positives = 64/135 (47%), Gaps = 10/135 (7%)

Query: 9   LVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGD-YHIDVCINDYLDVFCPHYED 67
           LV +V+W       P +K +     V W+S NP+F  G    I   I D LD+ CP  E 
Sbjct: 13  LVAMVVWALCRLATPLAKNLEP---VSWSSLNPKFLSGKGLVIYPKIGDKLDIICPRAEA 69

Query: 68  SVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLG 127
             P    E Y LY+V  +  +AC           CNRP      ++F+ KFQ F+P  +G
Sbjct: 70  GRPY---EYYKLYLVRPEQAAACSTVLDPNVLVTCNRPEQE---IRFTIKFQEFSPNYMG 123

Query: 128 FEFRPGREYFYISSA 142
            EF+   +Y+  S++
Sbjct: 124 LEFKKHHDYYITSTS 138


>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
          Length = 840

 Score = 30.4 bits (67), Expect = 1.3
 Identities = 16/62 (25%), Positives = 30/62 (48%), Gaps = 5/62 (8%)

Query: 29  ADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVL--YMVNFDG 86
           A  Y ++++ S P   +  +++     D  D+FC     S+  +K E++ L  Y    DG
Sbjct: 163 AQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTR---SIDREKYEQFALYGYATTADG 219

Query: 87  YS 88
           Y+
Sbjct: 220 YA 221


>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
           sapiens]
          Length = 894

 Score = 30.4 bits (67), Expect = 1.3
 Identities = 16/62 (25%), Positives = 30/62 (48%), Gaps = 5/62 (8%)

Query: 29  ADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVL--YMVNFDG 86
           A  Y ++++ S P   +  +++     D  D+FC     S+  +K E++ L  Y    DG
Sbjct: 163 AQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTR---SIDREKYEQFALYGYATTADG 219

Query: 87  YS 88
           Y+
Sbjct: 220 YA 221


>gi|7706326 splicing factor 3B, 14 kDa subunit [Homo sapiens]
          Length = 125

 Score = 30.4 bits (67), Expect = 1.3
 Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 3/37 (8%)

Query: 68  SVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNR 104
           + PE +   YV+Y   FD  +ACDH S GF    CNR
Sbjct: 52  NTPETRGTAYVVYEDIFDAKNACDHLS-GFN--VCNR 85


>gi|6912338 dynein, axonemal, intermediate chain 1 [Homo sapiens]
          Length = 699

 Score = 29.3 bits (64), Expect = 2.9
 Identities = 28/114 (24%), Positives = 48/114 (42%), Gaps = 8/114 (7%)

Query: 103 NRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIP---DNGRRSCLKLKVFVR 159
           N PH+P   +++S K   + P  +GF  +    Y  + + IP   D GRR   + ++ V 
Sbjct: 73  NNPHAPQNIVRYSFKEGTYKP--IGFVNQLAVHYTQVGNLIPKDSDEGRRQHYRDEL-VA 129

Query: 160 PTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSR--GENAAQTPRIP 211
            +   +K I     + +  +  E   EP   T   +A  +    E    TP+ P
Sbjct: 130 GSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQP 183


>gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens]
          Length = 576

 Score = 28.5 bits (62), Expect = 5.0
 Identities = 20/69 (28%), Positives = 29/69 (42%), Gaps = 4/69 (5%)

Query: 164 CMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSR----LLAILL 219
           C    G  D V     + ENS  P  DT  +  +P R     + P  P R    +  ++L
Sbjct: 46  CRDDSGTDDSVDTQQQQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVL 105

Query: 220 FLLAMLLTL 228
             LA++ TL
Sbjct: 106 DTLAVIRTL 114


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,583,439
Number of Sequences: 37866
Number of extensions: 436859
Number of successful extensions: 826
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 799
Number of HSP's gapped (non-prelim): 18
length of query: 228
length of database: 18,247,518
effective HSP length: 99
effective length of query: 129
effective length of database: 14,498,784
effective search space: 1870343136
effective search space used: 1870343136
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.