Guide to the Human Genome
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Search of human proteins with 4502015

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502015 A-kinase anchor protein 1 precursor [Homo sapiens]
         (903 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502015 A-kinase anchor protein 1 precursor [Homo sapiens]        1800   0.0  
gi|145312259 tudor and KH domain containing isoform a [Homo sapi...    64   6e-10
gi|145312246 tudor and KH domain containing isoform b [Homo sapi...    64   6e-10
gi|145312270 tudor and KH domain containing isoform a [Homo sapi...    64   6e-10
gi|145312256 tudor and KH domain containing isoform a [Homo sapi...    64   6e-10
gi|94421471 ring finger protein 17 [Homo sapiens]                      61   4e-09
gi|112293287 tudor domain containing 7 [Homo sapiens]                  61   4e-09
gi|38505161 tudor domain containing 1 [Homo sapiens]                   57   6e-08
gi|166851804 tudor domain containing 9 [Homo sapiens]                  56   2e-07
gi|56549694 enabled homolog isoform a [Homo sapiens]                   53   1e-06
gi|39930375 enabled homolog isoform b [Homo sapiens]                   53   1e-06
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              48   4e-05
gi|239754438 PREDICTED: hypothetical protein [Homo sapiens]            47   6e-05
gi|239748928 PREDICTED: hypothetical protein XP_002346859 [Homo ...    47   6e-05
gi|239742950 PREDICTED: hypothetical protein XP_002342702 [Homo ...    47   1e-04
gi|40255178 tudor domain containing 5 [Homo sapiens]                   46   2e-04
gi|14249452 zinc finger CCCH-type containing 10 [Homo sapiens]         45   3e-04
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    44   9e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    44   9e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    44   9e-04
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    44   9e-04
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    44   9e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    44   9e-04
gi|169212742 PREDICTED: similar to hCG1654128 [Homo sapiens]           43   0.001
gi|210032580 SET domain containing 1B [Homo sapiens]                   43   0.001
gi|169163653 PREDICTED: similar to tudor domain containing 1 [Ho...    43   0.002
gi|169164192 PREDICTED: similar to tudor domain containing 1 [Ho...    43   0.002
gi|169163210 PREDICTED: similar to tudor domain containing 1 [Ho...    43   0.002
gi|116008152 alpha 1 type XV collagen precursor [Homo sapiens]         42   0.003
gi|38261962 activating transcription factor 7 interacting protei...    41   0.004

>gi|4502015 A-kinase anchor protein 1 precursor [Homo sapiens]
          Length = 903

 Score = 1800 bits (4663), Expect = 0.0
 Identities = 903/903 (100%), Positives = 903/903 (100%)

Query: 1   MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPV 60
           MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPV
Sbjct: 1   MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPV 60

Query: 61  EDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLR 120
           EDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLR
Sbjct: 61  EDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLR 120

Query: 121 PGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQP 180
           PGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQP
Sbjct: 121 PGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQP 180

Query: 181 GYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLE 240
           GYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLE
Sbjct: 181 GYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLE 240

Query: 241 GEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGV 300
           GEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGV
Sbjct: 241 GEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGV 300

Query: 301 EGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEAT 360
           EGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEAT
Sbjct: 301 EGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEAT 360

Query: 361 EQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLP 420
           EQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLP
Sbjct: 361 EQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLP 420

Query: 421 LPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGI 480
           LPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGI
Sbjct: 421 LPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGI 480

Query: 481 LVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPEST 540
           LVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPEST
Sbjct: 481 LVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPEST 540

Query: 541 VPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGS 600
           VPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGS
Sbjct: 541 VPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGS 600

Query: 601 NPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS 660
           NPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS
Sbjct: 601 NPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS 660

Query: 661 QHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNA 720
           QHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNA
Sbjct: 661 QHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNA 720

Query: 721 GHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVV 780
           GHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVV
Sbjct: 721 GHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVV 780

Query: 781 ASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSP 840
           ASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSP
Sbjct: 781 ASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSP 840

Query: 841 EADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYY 900
           EADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYY
Sbjct: 841 EADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYY 900

Query: 901 TSL 903
           TSL
Sbjct: 901 TSL 903


>gi|145312259 tudor and KH domain containing isoform a [Homo
           sapiens]
          Length = 561

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 49/147 (33%), Positives = 78/147 (53%), Gaps = 14/147 (9%)

Query: 758 PVEITV----ICAAP-GADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRS 812
           P ++TV    I AAP   +G+W+RA+V+ + E  N +++ +VD+G      +  LR +RS
Sbjct: 349 PEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGN-LDLYFVDFGDNGDCPLKDLRALRS 407

Query: 813 DFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNT---ALLAQVTSYSPTGL-- 867
           DF++LPFQ  E  L  + P    DQ+  EA      +T       L+A+++SY  TG+  
Sbjct: 408 DFLSLPFQAIECSLARIAP--SGDQWEEEALDEFDRLTHCADWKPLVAKISSYVQTGIST 465

Query: 868 -PLIQLWSVVGDEVVLINRSLVERGLA 893
            P I L+     + + I   LV +G A
Sbjct: 466 WPKIYLYDTSNGKKLDIGLELVHKGYA 492



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 24/72 (33%), Positives = 39/72 (54%), Gaps = 8/72 (11%)

Query: 611 EIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYI-----STLPYTQSVQICHIEGSQHHVD 665
           ++ VP+  VGR+IG+ G  +  + + SGAKI        TL  ++ ++   I G+Q  V 
Sbjct: 128 QLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIK---ISGTQKEVA 184

Query: 666 KALNLIGKKFKE 677
            A +LI +K  E
Sbjct: 185 AAKHLILEKVSE 196



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 9/63 (14%)

Query: 611 EIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYIST---------LPYTQSVQICHIEGSQ 661
           E+ VP+  V  +IG+QG  +  L++ +GA+I + T         L     VQ+C  + + 
Sbjct: 56  EMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKAKAAI 115

Query: 662 HHV 664
           H +
Sbjct: 116 HQI 118


>gi|145312246 tudor and KH domain containing isoform b [Homo
           sapiens]
          Length = 516

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 49/147 (33%), Positives = 78/147 (53%), Gaps = 14/147 (9%)

Query: 758 PVEITV----ICAAP-GADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRS 812
           P ++TV    I AAP   +G+W+RA+V+ + E  N +++ +VD+G      +  LR +RS
Sbjct: 304 PEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGN-LDLYFVDFGDNGDCPLKDLRALRS 362

Query: 813 DFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNT---ALLAQVTSYSPTGL-- 867
           DF++LPFQ  E  L  + P    DQ+  EA      +T       L+A+++SY  TG+  
Sbjct: 363 DFLSLPFQAIECSLARIAP--SGDQWEEEALDEFDRLTHCADWKPLVAKISSYVQTGIST 420

Query: 868 -PLIQLWSVVGDEVVLINRSLVERGLA 893
            P I L+     + + I   LV +G A
Sbjct: 421 WPKIYLYDTSNGKKLDIGLELVHKGYA 447



 Score = 30.4 bits (67), Expect = 7.8
 Identities = 13/35 (37%), Positives = 23/35 (65%)

Query: 611 EIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYIST 645
           E+ VP+  V  +IG+QG  +  L++ +GA+I + T
Sbjct: 56  EMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDT 90


>gi|145312270 tudor and KH domain containing isoform a [Homo
           sapiens]
          Length = 561

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 49/147 (33%), Positives = 78/147 (53%), Gaps = 14/147 (9%)

Query: 758 PVEITV----ICAAP-GADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRS 812
           P ++TV    I AAP   +G+W+RA+V+ + E  N +++ +VD+G      +  LR +RS
Sbjct: 349 PEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGN-LDLYFVDFGDNGDCPLKDLRALRS 407

Query: 813 DFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNT---ALLAQVTSYSPTGL-- 867
           DF++LPFQ  E  L  + P    DQ+  EA      +T       L+A+++SY  TG+  
Sbjct: 408 DFLSLPFQAIECSLARIAP--SGDQWEEEALDEFDRLTHCADWKPLVAKISSYVQTGIST 465

Query: 868 -PLIQLWSVVGDEVVLINRSLVERGLA 893
            P I L+     + + I   LV +G A
Sbjct: 466 WPKIYLYDTSNGKKLDIGLELVHKGYA 492



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 24/72 (33%), Positives = 39/72 (54%), Gaps = 8/72 (11%)

Query: 611 EIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYI-----STLPYTQSVQICHIEGSQHHVD 665
           ++ VP+  VGR+IG+ G  +  + + SGAKI        TL  ++ ++   I G+Q  V 
Sbjct: 128 QLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIK---ISGTQKEVA 184

Query: 666 KALNLIGKKFKE 677
            A +LI +K  E
Sbjct: 185 AAKHLILEKVSE 196



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 9/63 (14%)

Query: 611 EIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYIST---------LPYTQSVQICHIEGSQ 661
           E+ VP+  V  +IG+QG  +  L++ +GA+I + T         L     VQ+C  + + 
Sbjct: 56  EMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKAKAAI 115

Query: 662 HHV 664
           H +
Sbjct: 116 HQI 118


>gi|145312256 tudor and KH domain containing isoform a [Homo
           sapiens]
          Length = 561

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 49/147 (33%), Positives = 78/147 (53%), Gaps = 14/147 (9%)

Query: 758 PVEITV----ICAAP-GADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRS 812
           P ++TV    I AAP   +G+W+RA+V+ + E  N +++ +VD+G      +  LR +RS
Sbjct: 349 PEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGN-LDLYFVDFGDNGDCPLKDLRALRS 407

Query: 813 DFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNT---ALLAQVTSYSPTGL-- 867
           DF++LPFQ  E  L  + P    DQ+  EA      +T       L+A+++SY  TG+  
Sbjct: 408 DFLSLPFQAIECSLARIAP--SGDQWEEEALDEFDRLTHCADWKPLVAKISSYVQTGIST 465

Query: 868 -PLIQLWSVVGDEVVLINRSLVERGLA 893
            P I L+     + + I   LV +G A
Sbjct: 466 WPKIYLYDTSNGKKLDIGLELVHKGYA 492



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 24/72 (33%), Positives = 39/72 (54%), Gaps = 8/72 (11%)

Query: 611 EIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYI-----STLPYTQSVQICHIEGSQHHVD 665
           ++ VP+  VGR+IG+ G  +  + + SGAKI        TL  ++ ++   I G+Q  V 
Sbjct: 128 QLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIK---ISGTQKEVA 184

Query: 666 KALNLIGKKFKE 677
            A +LI +K  E
Sbjct: 185 AAKHLILEKVSE 196



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 9/63 (14%)

Query: 611 EIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYIST---------LPYTQSVQICHIEGSQ 661
           E+ VP+  V  +IG+QG  +  L++ +GA+I + T         L     VQ+C  + + 
Sbjct: 56  EMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKAKAAI 115

Query: 662 HHV 664
           H +
Sbjct: 116 HQI 118


>gi|94421471 ring finger protein 17 [Homo sapiens]
          Length = 1623

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 38/138 (27%), Positives = 65/138 (47%), Gaps = 4/138 (2%)

Query: 765 CAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEV 824
           C A   DG W+RA+V+       EVE++YVD+G   ++ +  +R+I+ +F+  P +  + 
Sbjct: 733 CVAKFEDGIWYRAKVIG-LPGHQEVEVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKC 791

Query: 825 LLDSVMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGD---EVV 881
            L  + P     Q+S EA     E   +  +   V       + L++L+  +G       
Sbjct: 792 KLAYIEPYKRTMQWSKEAKEKFEEKAQDKFMTCSVIKILEDNVLLVELFDSLGAPEMTTT 851

Query: 882 LINRSLVERGLAQWVDSY 899
            IN  LV+ GLA +   Y
Sbjct: 852 SINDQLVKEGLASYEIGY 869



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 41/139 (29%), Positives = 65/139 (46%), Gaps = 15/139 (10%)

Query: 765  CAAPGADGAWWRAQVVASYE-ETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAE 823
            C A   DG W+RA++VA  E     + +++VDYG   ++ ++ L QI S  +  P +  +
Sbjct: 1486 CLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIK 1545

Query: 824  VLLDSVMPLSDD---------DQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWS 874
            VLL    P   D          ++S EA  AM +      L A   + +P      Q+ +
Sbjct: 1546 VLLAGFKPPLRDLGETRIPYCPKWSMEALWAMIDCLQGKQLYAVSMAPAPE-----QIVT 1600

Query: 875  VVGDEVVLINRSLVERGLA 893
            +  DE   ++  LVE GLA
Sbjct: 1601 LYDDEQHPVHMPLVEMGLA 1619



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 49/188 (26%), Positives = 82/188 (43%), Gaps = 11/188 (5%)

Query: 712  VIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGAD 771
            V + N ++   ++VQ     T + L SL+++M   Y        P   E  + CA    D
Sbjct: 920  VHICNVISPEKIYVQWLL--TENLLNSLEEKMIAAYENSKWE--PVKWENDMHCAVKIQD 975

Query: 772  -GAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVM 830
               W R Q++    +T  VE+   D G    V VD LR++  +  T+     E  L  + 
Sbjct: 976  KNQWRRGQIIRMVTDTL-VEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIR 1034

Query: 831  PLSDDDQFSPEA-DAAMSEMTGNTA-LLAQVTS---YSPTGLPLIQLWSVVGDEVVLINR 885
            P    D+++  A D     +TG  A ++ QV S    +   LP+         E V +++
Sbjct: 1035 PAGGSDKWTATACDCLSLYLTGAVATIILQVDSEENNTTWPLPVKIFCRDEKGERVDVSK 1094

Query: 886  SLVERGLA 893
             L+++GLA
Sbjct: 1095 YLIKKGLA 1102


>gi|112293287 tudor domain containing 7 [Homo sapiens]
          Length = 1098

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 50/208 (24%), Positives = 96/208 (46%), Gaps = 14/208 (6%)

Query: 702 LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI 761
           LM+P   +  V+VV   N   + ++        A   ++ +M   YS+    T    V +
Sbjct: 457 LMIPTEASPSVLVVELSNTNEVVIRYVGKDYSAAQELMEDEMKEYYSKNPKITPVQAVNV 516

Query: 762 TVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQG 821
             + A    + AW RAQV+++  E N++++ YVDYG  + V+     ++   F +L FQ 
Sbjct: 517 GQLLAVNAEEDAWLRAQVIST--EENKIKVCYVDYGFSENVEKSKAYKLNPKFCSLSFQA 574

Query: 822 AEVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVV 881
            +  L  +  LSDD    P+    +  +T       ++       +PL+ L+   G++ +
Sbjct: 575 TKCKLAGLEVLSDD----PDLVKVVESLTCGKIFAVEI--LDKADIPLVVLYDTSGEDDI 628

Query: 882 LIN----RSLVERGLA--QWVDSYYTSL 903
            IN    +++ ++ L     VD+ YT++
Sbjct: 629 NINATCLKAICDKSLEVHLQVDAMYTNV 656


>gi|38505161 tudor domain containing 1 [Homo sapiens]
          Length = 1189

 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 46/171 (26%), Positives = 71/171 (41%), Gaps = 10/171 (5%)

Query: 700 SWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPV 759
           +W+ L    TV+V+V    + G  +           L  L++ +     Q     LP   
Sbjct: 706 TWVELGVDQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQK----LPNGF 761

Query: 760 EITV---ICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVT 816
           +  +    CA    DG+W+RA +V        V++ +VDYG  + V  D LR I S F+ 
Sbjct: 762 KAEIGQPCCAFFAGDGSWYRA-LVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLN 820

Query: 817 LPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGL 867
           LPFQG    L  +   S +  +S EA            L A+V   +  G+
Sbjct: 821 LPFQGIRCQLADIQ--SRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGI 869



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 4/139 (2%)

Query: 763 VICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGA 822
           + CA    D  W+RA V+A Y     V + YVDYG ++ + +  L  I    + LP Q  
Sbjct: 547 ICCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAI 605

Query: 823 EVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVL 882
           + +L  V P      ++PEA   M ++  N  +  +V         L++L        V 
Sbjct: 606 KCVLAGVKP--SLGIWTPEAICLMKKLVQNKIITVKVVDKLENS-SLVELIDKSETPHVS 662

Query: 883 INRSLVERGLAQWVDSYYT 901
           +++ L++ G A    S  T
Sbjct: 663 VSKVLLDAGFAVGEQSMVT 681



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 22/69 (31%), Positives = 38/69 (55%), Gaps = 2/69 (2%)

Query: 765  CAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEV 824
            CA   +D  W+RA V+ + +   +VE+ Y DYG  + + +  ++ I S  + LPFQ    
Sbjct: 998  CAKYTSDDFWYRAVVLGTSD--TDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRC 1055

Query: 825  LLDSVMPLS 833
             L+ +M L+
Sbjct: 1056 SLEGLMELN 1064


>gi|166851804 tudor domain containing 9 [Homo sapiens]
          Length = 1382

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/203 (27%), Positives = 92/203 (45%), Gaps = 17/203 (8%)

Query: 708  ITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAA 767
            +T++V  V  V  GH +  +        L+ L  ++    +Q  +  LPT     ++C A
Sbjct: 900  LTIDVTEV--VEVGHFWGYRIDENNSEILKKLTAEI----NQLTLVPLPTHPHPDLVCLA 953

Query: 768  PGAD---GAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEV 824
            P AD     ++RAQV+  Y   N  E+ +VDYG    V + +L +I   F+ LPFQ  E 
Sbjct: 954  PFADFDKQRYFRAQVL--YVSGNSAEVFFVDYGNKSHVDLHLLMEIPCQFLELPFQALEF 1011

Query: 825  LLDSVMP----LSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPL-IQLWSVVGDE 879
             +  + P    L     +S  A    + +     LL +V S   + L + +  +S V D 
Sbjct: 1012 KICKMRPSAKSLVCGKHWSDGASQWFASLVSGCTLLVKVFSVVHSVLHVDVYQYSGVQD- 1070

Query: 880  VVLINRSLVERGLAQWVDSYYTS 902
             + I   L+++G A+  +  Y S
Sbjct: 1071 AINIRDVLIQQGYAELTEESYES 1093


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 68/276 (24%), Positives = 106/276 (38%), Gaps = 36/276 (13%)

Query: 224 HVLELENSK--GPSL----ASLEGEEDKGKSSSS------QVVGPVQEEEYVAEKLPSRF 271
           H LE+ NS+  GP+L    + L  +   G S         Q+    +++E   E+L    
Sbjct: 106 HALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERER 165

Query: 272 IESAHTELAK------DDAAPAPPVADAKAQDRGVEGELGNEESLDRNE-----EGLDRN 320
           +E    E  +      +         + + Q+R  +  L  +E L+R E     E LDR 
Sbjct: 166 MERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRE 225

Query: 321 EEGLDRNE--ESLDRNEEGLDRNEEIKRAAFQIISQ--VISEATEQVLATTVGKVAGRVC 376
            +     E  E L+R  +  +R E+++R   +   +  + S A    + T +  V G   
Sbjct: 226 RQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSS 285

Query: 377 QASQ-LQGQKEESCVPVHQKTVLGPDTAEP--------ATAEAAVAPPDAGLPLPGLPAE 427
            +   LQ   + +  P  Q  VLGP    P        A A  A+ PP    P P LP+ 
Sbjct: 286 ASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPST 345

Query: 428 GSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLAS 463
           G PPP         +   P     P + A    LAS
Sbjct: 346 GPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLAS 381


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 68/276 (24%), Positives = 106/276 (38%), Gaps = 36/276 (13%)

Query: 224 HVLELENSK--GPSL----ASLEGEEDKGKSSSS------QVVGPVQEEEYVAEKLPSRF 271
           H LE+ NS+  GP+L    + L  +   G S         Q+    +++E   E+L    
Sbjct: 106 HALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERER 165

Query: 272 IESAHTELAK------DDAAPAPPVADAKAQDRGVEGELGNEESLDRNE-----EGLDRN 320
           +E    E  +      +         + + Q+R  +  L  +E L+R E     E LDR 
Sbjct: 166 MERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRE 225

Query: 321 EEGLDRNE--ESLDRNEEGLDRNEEIKRAAFQIISQ--VISEATEQVLATTVGKVAGRVC 376
            +     E  E L+R  +  +R E+++R   +   +  + S A    + T +  V G   
Sbjct: 226 RQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSS 285

Query: 377 QASQ-LQGQKEESCVPVHQKTVLGPDTAEP--------ATAEAAVAPPDAGLPLPGLPAE 427
            +   LQ   + +  P  Q  VLGP    P        A A  A+ PP    P P LP+ 
Sbjct: 286 ASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPST 345

Query: 428 GSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLAS 463
           G PPP         +   P     P + A    LAS
Sbjct: 346 GPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLAS 381


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 66/291 (22%), Positives = 110/291 (37%), Gaps = 33/291 (11%)

Query: 159  SKSAEVCKQDSPFSRVPRKVQPGYPVVPAEKRSSGERARE--------TGGAEGTGDAVL 210
            S+  E  + +        + QP    V A+ +S GE A+E         G A+   D V 
Sbjct: 1997 SEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVE 2056

Query: 211  GEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVAEKLPSR 270
              +  EEA  +   V E E    P    ++ +E +G++          E E  A+K  + 
Sbjct: 2057 APEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQK--AE 2114

Query: 271  FIESAHTE---LAKDDAAPAPPV-ADAKAQDRGVEGELGNEESLDRNEEGLDRNE----- 321
             IE+  TE     + +   AP    +A+ +  GVE +    E+     EG++  E     
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEA-QPESEGIEAQEAEEEA 2173

Query: 322  ----EGLD--RNEESLDRNEEGLDRNEEIKRAAFQIISQVISEATEQVLATTVG----KV 371
                EG++    E       EG++  E    A  ++      EA E+      G    + 
Sbjct: 2174 QPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEA 2233

Query: 372  AGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLPLP 422
             G     S+ + Q E+   P   +  LG   +E A+  ++  P D   P P
Sbjct: 2234 EGEAQPESEGETQGEKKGSP---QVSLGDGQSEEASESSSPVPEDRPTPPP 2281



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 83/402 (20%), Positives = 139/402 (34%), Gaps = 26/402 (6%)

Query: 187  AEKRSSGERARETGG-AEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDK 245
            AE + + E A+E  G  +   + +  ++  EEA    E V  LE       A  E + + 
Sbjct: 1938 AEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES 1997

Query: 246  GKSSSSQVVGPVQEEEYVAEKLPSRFIE----SAHTELAKDDAAPAPPVADAKAQDRGVE 301
                + +  G +QE E  A+   S  +E    S   E  + +        DA+ +  GVE
Sbjct: 1998 EDVEAPEAEGEMQEAEEEAQP-ESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVE 2056

Query: 302  GELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVI-SEAT 360
                 EE+ +   E  +   E    +E+   +  EG  + E     A +   +   +E  
Sbjct: 2057 APEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI 2116

Query: 361  EQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLP 420
            E        +      +A + +G+ +     V  +   G    E    EA  A  +A   
Sbjct: 2117 EAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPE 2176

Query: 421  LPGLPA---EGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDR 477
            L G+ A   EG   P++        + +P  + +       +      A     E  P+ 
Sbjct: 2177 LEGVEAPEAEGEAQPES------EGIEAPEAEGEAQPELEGVE-----APEAEEEAQPEP 2225

Query: 478  AGILVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLP 537
             G+   +A         S+        G    S      E++   +S  P D+   PP P
Sbjct: 2226 EGVETPEAEGEA--QPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSP 2283

Query: 538  ESTVPFSN-GVLKGELSDLGAEDG--WTMDAEADHSGGSDRN 576
                P    G   G  S   +  G  W  D+E DH  G  R+
Sbjct: 2284 GGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRS 2325


>gi|239754438 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 709

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 66/237 (27%), Positives = 93/237 (39%), Gaps = 47/237 (19%)

Query: 375 VCQASQLQGQKEESCVPVHQ--KTVLGPDTAEPATAEAAVAP------PDAGLPLPGLPA 426
           VC A    G   +S  P+    + + GP   EP++A    AP      P AG    G P 
Sbjct: 274 VCAAPSAGGSPGKSDAPLRGWLRALRGP--REPSSAHTLGAPLGASPSPPAGRSWVGDP- 330

Query: 427 EGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGILVEDAT 486
            G+P      SC      +P + S P + A  +S  SCL      EE P       E+ +
Sbjct: 331 -GAPLTPRKASCS---WPAPGEASSPGLRAG-VSAFSCL------EEFPG------EECS 373

Query: 487 CVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETS---------SSPRDKAITPPLP 537
           C+  +  S +  P  +   +  +SFS       CT T+         SS    A  PPL 
Sbjct: 374 CLAVVVASGKGSPSASRGSNWGESFSWH----CCTATAAALLLQRGDSSASGGAAGPPLS 429

Query: 538 ESTVPFSNGVLKGELSDL------GAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLK 588
            S+   S G  +GE S L      G ED       A  S  + R+ + S  S C++K
Sbjct: 430 GSSPSASRGFSRGEPSSLVSVCFRGKEDEEKKPVLAAFSSRTVRSHLGSTSSTCNMK 486


>gi|239748928 PREDICTED: hypothetical protein XP_002346859 [Homo
           sapiens]
          Length = 709

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 66/237 (27%), Positives = 93/237 (39%), Gaps = 47/237 (19%)

Query: 375 VCQASQLQGQKEESCVPVHQ--KTVLGPDTAEPATAEAAVAP------PDAGLPLPGLPA 426
           VC A    G   +S  P+    + + GP   EP++A    AP      P AG    G P 
Sbjct: 274 VCAAPSAGGSPGKSDAPLRGWLRALRGP--REPSSAHTLGAPLGASPSPPAGRSWVGDP- 330

Query: 427 EGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGILVEDAT 486
            G+P      SC      +P + S P + A  +S  SCL      EE P       E+ +
Sbjct: 331 -GAPLTPRKASCS---WPAPGEASSPGLRAG-VSAFSCL------EEFPG------EECS 373

Query: 487 CVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETS---------SSPRDKAITPPLP 537
           C+  +  S +  P  +   +  +SFS       CT T+         SS    A  PPL 
Sbjct: 374 CLAVVVASGKGSPSASRGSNWGESFSWH----CCTATAAALLLQRGDSSASGGAAGPPLS 429

Query: 538 ESTVPFSNGVLKGELSDL------GAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLK 588
            S+   S G  +GE S L      G ED       A  S  + R+ + S  S C++K
Sbjct: 430 GSSPSASRGFSRGEPSSLVSVCFRGKEDEEKKPVLAAFSSRTVRSHLGSTSSTCNMK 486


>gi|239742950 PREDICTED: hypothetical protein XP_002342702 [Homo
           sapiens]
          Length = 709

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 66/237 (27%), Positives = 93/237 (39%), Gaps = 47/237 (19%)

Query: 375 VCQASQLQGQKEESCVPVHQ--KTVLGPDTAEPATAEAAVAP------PDAGLPLPGLPA 426
           VC A    G   +S  P+    + + GP   EP++A    AP      P AG    G P 
Sbjct: 274 VCAAPSAGGSPGKSDAPLGGWLRALRGP--REPSSAHTLGAPLGASPSPPAGRSWVGDP- 330

Query: 427 EGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGILVEDAT 486
            G+P      SC      +P + S P + A  +S  SCL      EE P       E+ +
Sbjct: 331 -GAPLTPRKASCS---WPAPGEASSPGLRAG-VSAFSCL------EEFPG------EECS 373

Query: 487 CVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETS---------SSPRDKAITPPLP 537
           C+  +  S +  P  +   +  +SFS       CT T+         SS    A  PPL 
Sbjct: 374 CLAVVVASGKGSPSASRGSNWGESFSWH----CCTATAAALLLQRGDSSASGGAAGPPLS 429

Query: 538 ESTVPFSNGVLKGELSDL------GAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLK 588
            S+   S G  +GE S L      G ED       A  S  + R+ + S  S C++K
Sbjct: 430 GSSPSASRGFSRGEPSSLVSVCFRGKEDEEKKPVLAAFSSRTVRSHLGSTSSTCNMK 486


>gi|40255178 tudor domain containing 5 [Homo sapiens]
          Length = 981

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/214 (21%), Positives = 86/214 (40%), Gaps = 15/214 (7%)

Query: 661 QHHVDKALNLIGKKFK--------ELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEV 712
           Q  + K  NL+ K  +        ELNL  +    +P  A+P+  +     L     + V
Sbjct: 417 QQKICKKPNLVVKPLQLQVETNKSELNLA-MANHDIPPDAVPNKKLCRLPPLDTSSLIGV 475

Query: 713 IVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITV----ICAAP 768
            V   ++    +++ ++  +   L  +  +M  CYS   +       E  +    +C   
Sbjct: 476 FVEYIISPSQFYIRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVR 535

Query: 769 GADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDS 828
            ++  WW   ++    E  EVE+ Y D+G    V+   LR ++  +  LP Q     L  
Sbjct: 536 ISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQKSSLRFLKCCYTKLPAQAIPCSLAW 595

Query: 829 VMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSY 862
           V P+  ++ ++ +A     ++ G   L+  V  Y
Sbjct: 596 VRPV--EEHWTSKAILQFQKLCGLKPLVGVVDEY 627


>gi|14249452 zinc finger CCCH-type containing 10 [Homo sapiens]
          Length = 434

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 67/271 (24%), Positives = 100/271 (36%), Gaps = 35/271 (12%)

Query: 246 GKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVAD-------AKAQDR 298
           G  S+  V+   + + Y    LP R  E       +      PP          + A  R
Sbjct: 174 GGGSTGSVLPGRRHDLYDIYDLPDRGFEDHEPGPKRRRGGCCPPDGPHFESYEYSLAPPR 233

Query: 299 GVEGELGNEES--LDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVI 356
           GVE  L  EE+  L +  E L +    L      L  NE  L++N + +  A  I     
Sbjct: 234 GVECRLLEEENAMLRKRVEELKKQVSNL------LATNEVLLEQNAQFRNQAKVITLSST 287

Query: 357 SEATEQVLATTVGKVA---GRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVA 413
           + ATEQ LA TVG VA     + Q       +     PV Q+ ++ P       A A  A
Sbjct: 288 APATEQTLAPTVGTVATFNHGIAQTHTTLSSQALQPRPVSQQELVAP-------AGAPAA 340

Query: 414 PPDAGLPLPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEE 473
           PP    P    PA   PPP      +  L ++  +     ++   +S+A       P   
Sbjct: 341 PPTNAAP----PAAPPPPPPHLTPEITPLSAALAQTIAQGMAPPPVSMAPVAVSVAPV-- 394

Query: 474 LPDRAGILVEDATCVTCMSDSSQSVPLVASP 504
               A + V  A  +  ++ S  + P+V  P
Sbjct: 395 ----APVAVSMAQPLAGITMSHTTTPMVTYP 421


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 69/298 (23%), Positives = 111/298 (37%), Gaps = 44/298 (14%)

Query: 35  SHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSV--------TEPPEKELSTVS 86
           S D ++  A     +A PA+K  +P    CPK  +T  S         T+ P K  +  S
Sbjct: 540 SADSEEAPAAMTAAQAKPALK--IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 597

Query: 87  KLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLE 146
              + P     T  P   S SS      +D          +  K  LA+T G+AKS+   
Sbjct: 598 PAGSSPAVAGGTQRPAEDSSSS----EESD---------SEEEKTGLAVTVGQAKSVG-- 642

Query: 147 CPLSSPKGVLFSSKSAEVCKQ--DSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEG 204
                 KG+   + S  V           +P K  P    V AEK+   E + E   +E 
Sbjct: 643 ------KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE- 695

Query: 205 TGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVA 264
             +A      ++ ++   +       ++ PS         K  ++++Q     ++     
Sbjct: 696 --EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA----KQRSPSK 749

Query: 265 EKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEE 322
            K P R  +++ T LA+    PA   +  KA     + + G EE    +EE  D  EE
Sbjct: 750 VKPPVRNPQNS-TVLAR---GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 803


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 69/298 (23%), Positives = 111/298 (37%), Gaps = 44/298 (14%)

Query: 35  SHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSV--------TEPPEKELSTVS 86
           S D ++  A     +A PA+K  +P    CPK  +T  S         T+ P K  +  S
Sbjct: 617 SADSEEAPAAMTAAQAKPALK--IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 674

Query: 87  KLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLE 146
              + P     T  P   S SS      +D          +  K  LA+T G+AKS+   
Sbjct: 675 PAGSSPAVAGGTQRPAEDSSSS----EESD---------SEEEKTGLAVTVGQAKSVG-- 719

Query: 147 CPLSSPKGVLFSSKSAEVCKQ--DSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEG 204
                 KG+   + S  V           +P K  P    V AEK+   E + E   +E 
Sbjct: 720 ------KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE- 772

Query: 205 TGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVA 264
             +A      ++ ++   +       ++ PS         K  ++++Q     ++     
Sbjct: 773 --EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA----KQRSPSK 826

Query: 265 EKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEE 322
            K P R  +++ T LA+    PA   +  KA     + + G EE    +EE  D  EE
Sbjct: 827 VKPPVRNPQNS-TVLAR---GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 69/298 (23%), Positives = 111/298 (37%), Gaps = 44/298 (14%)

Query: 35  SHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSV--------TEPPEKELSTVS 86
           S D ++  A     +A PA+K  +P    CPK  +T  S         T+ P K  +  S
Sbjct: 617 SADSEEAPAAMTAAQAKPALK--IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 674

Query: 87  KLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLE 146
              + P     T  P   S SS      +D          +  K  LA+T G+AKS+   
Sbjct: 675 PAGSSPAVAGGTQRPAEDSSSS----EESD---------SEEEKTGLAVTVGQAKSVG-- 719

Query: 147 CPLSSPKGVLFSSKSAEVCKQ--DSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEG 204
                 KG+   + S  V           +P K  P    V AEK+   E + E   +E 
Sbjct: 720 ------KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE- 772

Query: 205 TGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVA 264
             +A      ++ ++   +       ++ PS         K  ++++Q     ++     
Sbjct: 773 --EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA----KQRSPSK 826

Query: 265 EKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEE 322
            K P R  +++ T LA+    PA   +  KA     + + G EE    +EE  D  EE
Sbjct: 827 VKPPVRNPQNS-TVLAR---GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 69/298 (23%), Positives = 111/298 (37%), Gaps = 44/298 (14%)

Query: 35  SHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSV--------TEPPEKELSTVS 86
           S D ++  A     +A PA+K  +P    CPK  +T  S         T+ P K  +  S
Sbjct: 540 SADSEEAPAAMTAAQAKPALK--IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 597

Query: 87  KLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLE 146
              + P     T  P   S SS      +D          +  K  LA+T G+AKS+   
Sbjct: 598 PAGSSPAVAGGTQRPAEDSSSS----EESD---------SEEEKTGLAVTVGQAKSVG-- 642

Query: 147 CPLSSPKGVLFSSKSAEVCKQ--DSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEG 204
                 KG+   + S  V           +P K  P    V AEK+   E + E   +E 
Sbjct: 643 ------KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE- 695

Query: 205 TGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVA 264
             +A      ++ ++   +       ++ PS         K  ++++Q     ++     
Sbjct: 696 --EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA----KQRSPSK 749

Query: 265 EKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEE 322
            K P R  +++ T LA+    PA   +  KA     + + G EE    +EE  D  EE
Sbjct: 750 VKPPVRNPQNS-TVLAR---GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 803


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 69/298 (23%), Positives = 111/298 (37%), Gaps = 44/298 (14%)

Query: 35  SHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSV--------TEPPEKELSTVS 86
           S D ++  A     +A PA+K  +P    CPK  +T  S         T+ P K  +  S
Sbjct: 617 SADSEEAPAAMTAAQAKPALK--IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 674

Query: 87  KLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLE 146
              + P     T  P   S SS      +D          +  K  LA+T G+AKS+   
Sbjct: 675 PAGSSPAVAGGTQRPAEDSSSS----EESD---------SEEEKTGLAVTVGQAKSVG-- 719

Query: 147 CPLSSPKGVLFSSKSAEVCKQ--DSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEG 204
                 KG+   + S  V           +P K  P    V AEK+   E + E   +E 
Sbjct: 720 ------KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE- 772

Query: 205 TGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVA 264
             +A      ++ ++   +       ++ PS         K  ++++Q     ++     
Sbjct: 773 --EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA----KQRSPSK 826

Query: 265 EKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEE 322
            K P R  +++ T LA+    PA   +  KA     + + G EE    +EE  D  EE
Sbjct: 827 VKPPVRNPQNS-TVLAR---GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 69/298 (23%), Positives = 111/298 (37%), Gaps = 44/298 (14%)

Query: 35  SHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSV--------TEPPEKELSTVS 86
           S D ++  A     +A PA+K  +P    CPK  +T  S         T+ P K  +  S
Sbjct: 617 SADSEEAPAAMTAAQAKPALK--IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 674

Query: 87  KLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLE 146
              + P     T  P   S SS      +D          +  K  LA+T G+AKS+   
Sbjct: 675 PAGSSPAVAGGTQRPAEDSSSS----EESD---------SEEEKTGLAVTVGQAKSVG-- 719

Query: 147 CPLSSPKGVLFSSKSAEVCKQ--DSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEG 204
                 KG+   + S  V           +P K  P    V AEK+   E + E   +E 
Sbjct: 720 ------KGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE- 772

Query: 205 TGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVA 264
             +A      ++ ++   +       ++ PS         K  ++++Q     ++     
Sbjct: 773 --EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA----KQRSPSK 826

Query: 265 EKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEE 322
            K P R  +++ T LA+    PA   +  KA     + + G EE    +EE  D  EE
Sbjct: 827 VKPPVRNPQNS-TVLAR---GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE 880


>gi|169212742 PREDICTED: similar to hCG1654128 [Homo sapiens]
          Length = 1015

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 64/260 (24%), Positives = 102/260 (39%), Gaps = 41/260 (15%)

Query: 92  PPALLQTHPPCR-RSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLS 150
           PP L   HP  +  SE+ G     T +R+   T      +L +A   G   S+PL    S
Sbjct: 110 PPGLQPRHPTAQIPSETEG-----TCVRITLPTLDHQPVRLRVAQPSG--LSVPLFSHAS 162

Query: 151 S---PKGVLFSSKSAEVCKQDSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEGTGD 207
           S   P    F +   E  +++     V ++V P           +G +  + G     G 
Sbjct: 163 SRPHPHSPCFFTCQGESFREEKEM--VTQRVSPP---------PAGSQRTQAGSGHCAGG 211

Query: 208 AVLGEKVLEEALLSREHVLELENSKGPSLASLE----GEEDKGKSSSSQVVGPVQEEEYV 263
            +  EK   +A  +   V + E+  GP  AS      G+E+ G   +S     V ++E  
Sbjct: 212 LLGHEKHAMDASPTEHGVGQEED--GPEDASPTEHDVGQEEDGPEDASPTEHGVDQQEDG 269

Query: 264 AEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEEG 323
            E       +++ TE   D     P   DA+  + GV+ E    E     E G+D+ E+G
Sbjct: 270 PE-------DASPTEHGVDQQEDGPE--DARPTEHGVDQEEDGPEDASLTEHGVDQQEDG 320

Query: 324 LDRNEESLDRNEEGLDRNEE 343
                E     E G+D+ E+
Sbjct: 321 ----PEDASPTEHGIDQEED 336



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 42/163 (25%), Positives = 59/163 (36%), Gaps = 21/163 (12%)

Query: 223 EHVLELENSKGPSLASL-----EGEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHT 277
           EH ++ E   GP  ASL     + +ED  + +S    G  QEE+   +  P        T
Sbjct: 294 EHGVDQEED-GPEDASLTEHGVDQQEDGPEDASPTEHGIDQEEDGPEDASP--------T 344

Query: 278 ELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEG 337
           E   D     P  A     + GV+ E    E     E G+D+ +       E     E G
Sbjct: 345 EHGVDQEEDGPEDASPTEHEHGVDQEEDGPEDASPTEHGVDQED-----GPEDARPTEHG 399

Query: 338 LDRNE--EIKRAAFQIISQVISEATEQVLATTVGKVAGRVCQA 378
           +D+ +  E  R     + Q             VG  AGR C A
Sbjct: 400 VDQEDGPEDARPTEHGVDQEDGPEDASRTEHGVGHRAGRACAA 442


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 111/494 (22%), Positives = 157/494 (31%), Gaps = 82/494 (16%)

Query: 103  RRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSA 162
            +R E      +    RLRP T  D+  +        +    P E     PKGV    + A
Sbjct: 965  KRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPA 1024

Query: 163  EVCKQDSPFSRVPRK-VQPGYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLS 221
               + DS      ++ +         E+ +  E   E    + + D    E   E+  LS
Sbjct: 1025 RPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALS 1084

Query: 222  R-----------EHVLELENSKGPSLASLEGEEDKGKSSSSQ------------VVGPVQ 258
                        E  + +  SK  + +S E  E     SSS+            V    +
Sbjct: 1085 EASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEE 1144

Query: 259  EEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLD 318
            EEE   E +    + SA  E  + D   A     A A D      LG EE +D   E + 
Sbjct: 1145 EEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVD-----SLGMEEEVDIETEAVA 1199

Query: 319  RNEEGLDRNEESLDRN-EEGLDRNEEIKRAAFQIISQVISEATEQVLATTVGKVAGRVCQ 377
              E     +E  L    EE  D  E  +                               Q
Sbjct: 1200 PEERPSMLDEPPLPVGVEEPADSREPPEEPGLS--------------------------Q 1233

Query: 378  ASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPP-------DAGLPLPGLPAEGSP 430
               +    E     V  +  L P+ A     E    PP          LP P  P   SP
Sbjct: 1234 EGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSP 1293

Query: 431  P--PKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGILVEDATCV 488
            P  P+T  +   S+   P  +  P    H   L   LA +  +E +P   G     +   
Sbjct: 1294 PPEPETTDASHPSVPPEPLAEDHP---PHTPGLCGSLAKSQSTETVPATPGGEPPLSGGS 1350

Query: 489  TCMSDSSQSVP------LVASPGHCSDSF-STSGLEDSCTETSSSPRDKAITP--PLP-- 537
            + +S SS  VP         SP   S     T G + S T T S P    + P  PLP  
Sbjct: 1351 SGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPSGPLLLPVCPLPTG 1410

Query: 538  ---ESTVPFSNGVL 548
               E + P ++ VL
Sbjct: 1411 RRDERSGPLASPVL 1424



 Score = 33.5 bits (75), Expect = 0.92
 Identities = 40/165 (24%), Positives = 65/165 (39%), Gaps = 21/165 (12%)

Query: 46   VQLRADPAIKEPLPVEDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPA-LLQTHPP--- 101
            +++  +P +  PLP++   P     PP    PP +  +T +  P+ PP  L + HPP   
Sbjct: 1264 LEVEPEPPMMLPLPLQPPLPP--PRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTP 1321

Query: 102  -----CRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVL 156
                   +S+S+  +P T       G          L+L+  +    P   P  SP   L
Sbjct: 1322 GLCGSLAKSQSTETVPATPG-----GEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPS--L 1374

Query: 157  FSSKSAEVCKQDSPFSRVPRKVQPGYP-VVPAEKRSSGERARETG 200
             S        +D  FS  P   +P  P ++P     +G R   +G
Sbjct: 1375 SSGGLPRTPGRD--FSFTPTFSEPSGPLLLPVCPLPTGRRDERSG 1417


>gi|169163653 PREDICTED: similar to tudor domain containing 1 [Homo
           sapiens]
          Length = 2080

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 10/125 (8%)

Query: 736 LRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVD 795
           L +L   M L Y      T PT     ++C A   +G W R  ++      N+V+I ++D
Sbjct: 413 LENLTAHMTLHYDTVCQETSPTCDNFGLLCVARRRNGQWHRG-ILQQLLPPNQVKIWFMD 471

Query: 796 YGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMT-GNTA 854
           YG  + +    +++++ DF+ +P            P S     SP+ DA + +++    A
Sbjct: 472 YGSSEAIPSIYVKKLKQDFILVPLFS--------FPCSLTCLHSPDRDARIFQLSIFKQA 523

Query: 855 LLAQV 859
           LL QV
Sbjct: 524 LLGQV 528



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 24/70 (34%), Positives = 33/70 (47%), Gaps = 2/70 (2%)

Query: 758  PVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTL 817
            P EI          G W RA V+   + + EV+I +VDYG  KRV ++ L  I   F+ L
Sbjct: 945  PYEIGQTACVAKYSGKWCRAAVLT--QVSKEVDIVFVDYGYQKRVLIEDLCAINPRFLLL 1002

Query: 818  PFQGAEVLLD 827
              Q     L+
Sbjct: 1003 ESQAFRCCLN 1012



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 19/72 (26%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 758  PVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTL 817
            P+   ++ A    D A +RA V+      N  E+ ++DYG    V    + +++ +F+T+
Sbjct: 1489 PLVGDLVVAEYSGDNAIYRA-VIKKILPGNSFEVEFIDYGNSAIVNTSKIYELQREFLTV 1547

Query: 818  PFQGAEVLLDSV 829
            P  G    L  V
Sbjct: 1548 PQLGIHAFLSGV 1559


>gi|169164192 PREDICTED: similar to tudor domain containing 1 [Homo
           sapiens]
          Length = 2080

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 10/125 (8%)

Query: 736 LRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVD 795
           L +L   M L Y      T PT     ++C A   +G W R  ++      N+V+I ++D
Sbjct: 413 LENLTAHMTLHYDTVCQETSPTCDNFGLLCVARRRNGQWHRG-ILQQLLPPNQVKIWFMD 471

Query: 796 YGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMT-GNTA 854
           YG  + +    +++++ DF+ +P            P S     SP+ DA + +++    A
Sbjct: 472 YGSSEAIPSIYVKKLKQDFILVPLFS--------FPCSLTCLHSPDRDARIFQLSIFKQA 523

Query: 855 LLAQV 859
           LL QV
Sbjct: 524 LLGQV 528



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 24/70 (34%), Positives = 33/70 (47%), Gaps = 2/70 (2%)

Query: 758  PVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTL 817
            P EI          G W RA V+   + + EV+I +VDYG  KRV ++ L  I   F+ L
Sbjct: 945  PYEIGQTACVAKYSGKWCRAAVLT--QVSKEVDIVFVDYGYQKRVLIEDLCAINPRFLLL 1002

Query: 818  PFQGAEVLLD 827
              Q     L+
Sbjct: 1003 ESQAFRCCLN 1012



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 19/72 (26%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 758  PVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTL 817
            P+   ++ A    D A +RA V+      N  E+ ++DYG    V    + +++ +F+T+
Sbjct: 1489 PLVGDLVVAEYSGDNAIYRA-VIKKILPGNSFEVEFIDYGNSAIVNTSKIYELQREFLTV 1547

Query: 818  PFQGAEVLLDSV 829
            P  G    L  V
Sbjct: 1548 PQLGIHAFLSGV 1559


>gi|169163210 PREDICTED: similar to tudor domain containing 1 [Homo
           sapiens]
          Length = 2080

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/125 (26%), Positives = 57/125 (45%), Gaps = 10/125 (8%)

Query: 736 LRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVD 795
           L +L   M L Y      T PT     ++C A   +G W R  ++      N+V+I ++D
Sbjct: 413 LENLTAHMTLHYDTVCQETSPTCDNFGLLCVARRRNGQWHRG-ILQQLLPPNQVKIWFMD 471

Query: 796 YGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMT-GNTA 854
           YG  + +    +++++ DF+ +P            P S     SP+ DA + +++    A
Sbjct: 472 YGSSEAIPSIYVKKLKQDFILVPLFS--------FPCSLTCLHSPDRDARIFQLSIFKQA 523

Query: 855 LLAQV 859
           LL QV
Sbjct: 524 LLGQV 528



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 24/70 (34%), Positives = 33/70 (47%), Gaps = 2/70 (2%)

Query: 758  PVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTL 817
            P EI          G W RA V+   + + EV+I +VDYG  KRV ++ L  I   F+ L
Sbjct: 945  PYEIGQTACVAKYSGKWCRAAVLT--QVSKEVDIVFVDYGYQKRVLIEDLCAINPRFLLL 1002

Query: 818  PFQGAEVLLD 827
              Q     L+
Sbjct: 1003 ESQAFRCCLN 1012



 Score = 34.3 bits (77), Expect = 0.54
 Identities = 19/72 (26%), Positives = 34/72 (47%), Gaps = 1/72 (1%)

Query: 758  PVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTL 817
            P+   ++ A    D A +RA V+      N  E+ ++DYG    V    + +++ +F+T+
Sbjct: 1489 PLVGDLVVAEYSGDNAIYRA-VIKKILPGNSFEVEFIDYGNSAIVNTSKIYELQREFLTV 1547

Query: 818  PFQGAEVLLDSV 829
            P  G    L  V
Sbjct: 1548 PQLGIHAFLSGV 1559


>gi|116008152 alpha 1 type XV collagen precursor [Homo sapiens]
          Length = 1388

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 94/381 (24%), Positives = 144/381 (37%), Gaps = 58/381 (15%)

Query: 244 DKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGE 303
           D  +SS+S     +QE + VAE L +     A  + AK +    PP   +  +D  + GE
Sbjct: 236 DPEESSASGETSGLQEADGVAEILEAVTYTQASPKEAKVEPINTPPTPSSPFEDMELSGE 295

Query: 304 LGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDR-NEEIKRAAFQIISQVISEATEQ 362
              E +L+     + ++      + E L+   EG+   + +    +       +  A E+
Sbjct: 296 PVPEGTLETTNMSIIQHSSPKQGSGEILNDTLEGVHSVDGDPITDSGSGAGAFLDIAEEK 355

Query: 363 VLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVL------------GPDTAEPATAEA 410
            LA T    AG         G+ E S VP    T+             GPD  E   A A
Sbjct: 356 NLAAT---AAGLAEVPISTAGEAEASSVPTGGPTLSMSTENPEEGVTPGPDNEERLAATA 412

Query: 411 AVAPPDAGLPLPG-LPAEGSPPPKTYVS-CLKSLLSSPTKDSKPNISAHHISLASCLALT 468
           A    +A   +PG + A G  P +  +S   +SL    T       S    + A+ ++L+
Sbjct: 413 A-GEAEALASMPGEVEASGVAPGELDLSMSAQSLGEEATVGPSSEDSLTTAAAATEVSLS 471

Query: 469 TPSEELPDRAGILVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCT----ETS 524
           T  +E  + +G+  +    +T      ++V   + PG   D  + +  E   T    E+ 
Sbjct: 472 TFEDE--EASGVPTDGLAPLTATMAPERAV--TSGPGDEEDLAAATTEEPLITAGGEESG 527

Query: 525 SSPRDKAITPPLPESTVPFSNGVL---------------KGELSDLGAE----------D 559
           S P D    PPLP  TV     +                KGE  D G E           
Sbjct: 528 SPPPD---GPPLPLPTVAPERWITPAQREHVGMKGQAGPKGEKGDAGEELPGPPEPSGPV 584

Query: 560 GWTMDAEADHSG---GSDRNS 577
           G T  AEA+ SG   GSD  S
Sbjct: 585 GPTAGAEAEGSGLGWGSDVGS 605


>gi|38261962 activating transcription factor 7 interacting protein
           [Homo sapiens]
          Length = 1270

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 98/463 (21%), Positives = 163/463 (35%), Gaps = 53/463 (11%)

Query: 70  TPPSVTEPPEKELSTVSKLPAEP------PALLQTHPPCRRSESSGILPNTTDMRLRPGT 123
           +P ++T  P      VSKLPAEP      P  L    P     +SG+L +       P +
Sbjct: 113 SPHNITPEP------VSKLPAEPVSGDPAPGDLDAGDP-----ASGVLASGDSTSGDPTS 161

Query: 124 RRDDSTKLELA-LTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQPGY 182
               S+       T G+A S  +     SP        +A+      P S  P    PG 
Sbjct: 162 SEPSSSDAASGDATSGDAPSGDV-----SPGDATSGDATADDLSSGDPTSSDPI---PGE 213

Query: 183 PVVPAEKRSSGERARETGGAEGTG-DAVLGEKVLEEALLSREHVLELENSKGPSLASLEG 241
           PV P E  S    A +   +E T  D   G     +         +L +S+  S     G
Sbjct: 214 PV-PVEPISGDCAADDIASSEITSVDLASGAPASTDPASDDLASGDLSSSELASDDLATG 272

Query: 242 EEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVE 301
           E    + +S        E + V    P   I++      KDD       AD K +    +
Sbjct: 273 ELASDELTSESTFDRTFEPKSVPVCEPVPEIDNIEPSSNKDDDFLEKNGADEKLEQIQSK 332

Query: 302 GELGNEESLDRNEEGLDRNEEGLDRNEESL--DRNEEGLDRNEEIKRAAFQIISQVISEA 359
             L  +   D N   +D NEE L+ ++ ++  DR  E   + EE       +    IS +
Sbjct: 333 DSLDEKNKADNN---IDANEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSS 389

Query: 360 TEQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGL 419
            E             + Q  + + +     V    + V+  + +E           D  +
Sbjct: 390 ME-------------IDQGEKNEDETSADLVETINENVIEDNKSENILENTDSMETDEII 436

Query: 420 PLPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAG 479
           P+     E   P +  ++C       P  ++ P++     S     +    SE LP  A 
Sbjct: 437 PI----LEKLAPSEDELTCFSKTSLLPIDETNPDLEEKMESSFGSPSKQESSESLPKEAF 492

Query: 480 ILVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTE 522
           +++ D   ++   D S+   +++    CS +   S  +D+  E
Sbjct: 493 LVLSDEEDISGEKDESE---VISQNETCSPAEVESNEKDNKPE 532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,571,823
Number of Sequences: 37866
Number of extensions: 1997771
Number of successful extensions: 9206
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 244
Number of HSP's that attempted gapping in prelim test: 8259
Number of HSP's gapped (non-prelim): 1064
length of query: 903
length of database: 18,247,518
effective HSP length: 111
effective length of query: 792
effective length of database: 14,044,392
effective search space: 11123158464
effective search space used: 11123158464
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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