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Search of human proteins with 44917604
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo
sapiens]
(1085 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 2182 0.0
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 1466 0.0
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 1417 0.0
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 1410 0.0
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 1220 0.0
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 784 0.0
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 121 4e-27
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 114 4e-25
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 112 2e-24
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 112 2e-24
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 111 3e-24
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 111 4e-24
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 111 4e-24
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 109 2e-23
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 109 2e-23
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 106 1e-22
gi|54860079 nadrin isoform 1 [Homo sapiens] 103 1e-21
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 101 3e-21
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 100 6e-21
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 100 6e-21
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 100 1e-20
gi|54860105 nadrin isoform 2 [Homo sapiens] 97 6e-20
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 97 1e-19
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 97 1e-19
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 93 2e-18
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 93 2e-18
gi|4757766 Rho GTPase activating protein 1 [Homo sapiens] 91 8e-18
gi|188497642 ARHGAP15 [Homo sapiens] 90 1e-17
gi|229094128 active breakpoint cluster region-related protein i... 90 1e-17
gi|38679957 active breakpoint cluster region-related protein is... 90 1e-17
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapiens]
Length = 1085
Score = 2182 bits (5655), Expect = 0.0
Identities = 1085/1085 (100%), Positives = 1085/1085 (100%)
Query: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE
Sbjct: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
Query: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI
Sbjct: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
Query: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES
Sbjct: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
Query: 181 KLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKAR 240
KLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKAR
Sbjct: 181 KLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKAR 240
Query: 241 NEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLD 300
NEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLD
Sbjct: 241 NEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLD 300
Query: 301 IIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQ 360
IIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQ
Sbjct: 301 IIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQ 360
Query: 361 QLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYL 420
QLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYL
Sbjct: 361 QLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYL 420
Query: 421 SKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRP 480
SKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRP
Sbjct: 421 SKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRP 480
Query: 481 PNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGI 540
PNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGI
Sbjct: 481 PNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGI 540
Query: 541 FRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDL 600
FRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDL
Sbjct: 541 FRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDL 600
Query: 601 ISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFG 660
ISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFG
Sbjct: 601 ISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFG 660
Query: 661 PTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYS 720
PTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYS
Sbjct: 661 PTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYS 720
Query: 721 EHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDW 780
EHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDW
Sbjct: 721 EHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDW 780
Query: 781 WEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRH 840
WEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRH
Sbjct: 781 WEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRH 840
Query: 841 PDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNR 900
PDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNR
Sbjct: 841 PDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNR 900
Query: 901 GLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQ 960
GLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQ
Sbjct: 901 GLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQ 960
Query: 961 DIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSS 1020
DIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSS
Sbjct: 961 DIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSS 1020
Query: 1021 EPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTD 1080
EPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTD
Sbjct: 1021 EPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTD 1080
Query: 1081 KSCTM 1085
KSCTM
Sbjct: 1081 KSCTM 1085
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo
sapiens]
Length = 1099
Score = 1466 bits (3796), Expect = 0.0
Identities = 753/1095 (68%), Positives = 891/1095 (81%), Gaps = 23/1095 (2%)
Query: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
MS+ ++FKKDKEIIAEYE+Q+KEIR QLVEQ KCLEQQ+E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
EYSR+LEKLAERF +K RS+++HQ +KKDQ LLSPVNCWYL+L+Q RRES+DHATL+DI
Sbjct: 61 LEYSRSLEKLAERFSSKIRSSREHQ-FKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDI 119
Query: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
++NNVI+R QISED R+FKKSKEI Q+HE+L+KV NELYTVMKTYHMYHAESISAES
Sbjct: 120 FMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAES 179
Query: 181 KLKEAEKQEEKQIGRSGDPVFHI-RLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKA 239
KLKEAEKQEEKQ +SGD ++ R E+R QRRSSVKKIEKMKEKRQAKYSENKLK KA
Sbjct: 180 KLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKA 239
Query: 240 RNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGL 299
RN+YLL L ATNA++ KYYIHD+SDLIDCCDLG+HASL R RTYLSAEYNLETSRHEGL
Sbjct: 240 RNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGL 299
Query: 300 DIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRY 359
D+IENAVDNL+ RSDK M+M FCPP+KFEFQ HMGDEVCQVSAQQPVQ EL++RY
Sbjct: 300 DVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRY 359
Query: 360 QQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETY 419
QLQSRLATLKIENEEV+KT +AT+QT+QDM+T+ED+DVS+ FQHSRSTESVKS SETY
Sbjct: 360 HQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETY 419
Query: 420 LSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTR 479
+SK +IAKRRANQQETE FYF K +EY+ GSNLITKLQAKHDLL++TLGEG RAE TTR
Sbjct: 420 MSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTR 479
Query: 480 PPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQG 539
PP +PPKPQK R+ RP S Y+ KLFNG +E F+KDSGQ IPL+VESCIR+INLYGLQ QG
Sbjct: 480 PPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQG 539
Query: 540 IFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFND 599
IFRV GSQVEVNDIKNSFERGE+PL DDQ+ DINSVAGVLKLYFRGLENPLFPKERF D
Sbjct: 540 IFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQD 599
Query: 600 LISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICF 659
LIS I+++N ER I+++L+TLPR V++VMRYLFAFLNHLSQYSDENMMDPYNLAICF
Sbjct: 600 LISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICF 659
Query: 660 GPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMA-GDDYCDSP 718
GPTLM +P+ QD VSCQAH+NE+IKTIIIHHE IFP +EL+GPVYEKCMA G++YCDSP
Sbjct: 660 GPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSP 719
Query: 719 YSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASE 778
+SE G ++EVD D GTEPHTS++E E IEAIAKFDY+GRS RELSFKKGASLLLYHRASE
Sbjct: 720 HSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASE 779
Query: 779 DWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSK-DMNSPT 837
DWWEGRHNG+DGL+PHQYIVVQDMDD FSD+LSQKADSEASSGP+ +DK+SSK D+ SPT
Sbjct: 780 DWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPT 839
Query: 838 DRHPD----GYLARQRKRGEPPP-PVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLA-- 890
+ D G + R R R + P RR G D H PP L S+D + A
Sbjct: 840 EHISDYGFGGVMGRVRLRSDGAAIPRRRSG--GDTH---SPPRGL-GPSIDTPPRAAACP 893
Query: 891 SHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDH 950
S P + RG +SPE+RR GS +I+ D + +R + S +++ DH
Sbjct: 894 SSPHKIPLTRG-RIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDH 952
Query: 951 KPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLS 1010
K L+ E +A+DIE+TM+TAL+ELRELERQ+T K APDVVLDTLE +KN P P S+E S
Sbjct: 953 KSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGP-VSSEPAS 1011
Query: 1011 PLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRM-GVQLKPPALRP-KPAVLPK--TN 1066
PLH + +R + +RRS+SSS++ M+TFKP ++ R+ G QL+PP +RP +P V + ++
Sbjct: 1012 PLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSS 1071
Query: 1067 PTIGPAPPPQGPTDK 1081
+ G P PT+K
Sbjct: 1072 SSSGVGSPAVTPTEK 1086
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 1417 bits (3667), Expect = 0.0
Identities = 736/1108 (66%), Positives = 872/1108 (78%), Gaps = 60/1108 (5%)
Query: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
M++P++FKKDKEIIAEY++QVKEIRAQL EQ KCL+QQ E+RVQLLQDLQDFFRKKAEIE
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
+YSRNLEKLAERF+AKTRSTKD QQ+KKDQN+LSPVNCW LLLNQV+RES+DH TLSDI
Sbjct: 61 MDYSRNLEKLAERFLAKTRSTKD-QQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDI 119
Query: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
YLNN+I RF+Q+SEDS R+FKKSKE+ QL +DLMKVLNELY+VMKTYHMY+A+SISA+S
Sbjct: 120 YLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQS 179
Query: 181 KLKEAEKQEEKQIG-----------RSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKY 229
KLKEAEKQEEKQIG RS D ++R+EE+H RRSSVKKIEKMKEKRQAKY
Sbjct: 180 KLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKY 239
Query: 230 SENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLID-CCDLGYHASLNRALRTYLSAE 288
+ENKLK+IKARNEYLL LEATNASVFKYYIHDLSDLID CCDLGYHASLNRALRT+LSAE
Sbjct: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
Query: 289 YNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQ 348
NLE S+HEGLD IENAV+NL+ SDKQR MEMY FCPPMKFEFQ HMGD Q+ AQ
Sbjct: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
Query: 349 QPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRST 408
QPVQ+EL+ R QQLQSRL+TLKIENEEVKKT EATLQTIQD+VT+ED+DVS+CFQ+S S
Sbjct: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
Query: 409 ESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLG 468
ESVKSTVSET++SKPSIAKRRANQQETEQFYF K++EYLEG NLITKLQAKHDLLQ+TLG
Sbjct: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
Query: 469 EGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIR 528
E R + R R S R Q DS Q IPL+VESCIR
Sbjct: 480 ESQRTDCSLAR-----------RSSTVRKQ---------------DSSQAIPLVVESCIR 513
Query: 529 FINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLE 588
FI+ +GLQH+GIFRVSGSQVEVNDIKN+FERGE+PLA DQ++HD++S+AGVLKLYFRGLE
Sbjct: 514 FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
Query: 589 NPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDEN 648
+PLFPK+ F+DL++C+ +DNL ERALHIRK+LL LP++ LI+MRYLFAFLNHLSQ+S+EN
Sbjct: 574 HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
Query: 649 MMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKC 708
MMDPYNLAICFGP+LM VPE DQVSCQAHVNE+IKTIII HE IFP +EL+GPVY +
Sbjct: 634 MMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRG 693
Query: 709 MAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGA 768
+ +DYCDSP+ E ++E+ QD E HTS+DECEPIEAIAKFDYVGR+ARELSFKKGA
Sbjct: 694 GSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGA 753
Query: 769 SLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKS 828
SLLLY RAS+DWWEGRHNGIDGL+PHQYIVVQD +D + S K++ E S P E +
Sbjct: 754 SLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVT 813
Query: 829 SSKDMNSPTDRH-PDGYLA---RQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDL 884
+ + P+ H D YLA +QRKR E +R+ R+ H LS+S D
Sbjct: 814 ARAGASCPSGGHVADIYLANINKQRKRPE-SGSIRKTFRSDS--------HGLSSSLTDS 864
Query: 885 GSPSLASHPRGLLQ---NRGLNNDSPERRRRPGHGSLTNISRHDSLK-KIDSPPIRRSTS 940
SP + + R Q ++ L + P++ GHGSL +ISRH SLK ++DSP IR++ +
Sbjct: 865 SSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTAT 924
Query: 941 SGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSP 1000
+G+ FN+H+P+DPE IAQDIE TMN+ALNELRELERQS+ KH PDVVLDTLE +K SP
Sbjct: 925 AGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSP 984
Query: 1001 TPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPA 1060
A ++E SPLH L+ EP +RS S++ D F+P+ + +M +KPPA RPKP
Sbjct: 985 VVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPT 1044
Query: 1061 VLPKTN---PTIGPAPPPQGPTDKSCTM 1085
V PKTN P + + PQ TDKSCT+
Sbjct: 1045 VFPKTNATSPGVNSSTSPQS-TDKSCTV 1071
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b [Homo
sapiens]
Length = 1075
Score = 1410 bits (3651), Expect = 0.0
Identities = 736/1095 (67%), Positives = 871/1095 (79%), Gaps = 47/1095 (4%)
Query: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
MS+ ++FKKDKEIIAEYE+Q+KEIR QLVEQ KCLEQQ+E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
EYSR+LEKLAERF +K RS+++HQ +KKDQ LLSPVNCWYL+L+Q RRES+DHATL+DI
Sbjct: 61 LEYSRSLEKLAERFSSKIRSSREHQ-FKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDI 119
Query: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
++NNVI+R QISED R+FKKSKEI Q+HE+L+KV NELYTVMKTYHMYHAESISAES
Sbjct: 120 FMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAES 179
Query: 181 KLKEAEKQEEKQIGRSGDPVFHI-RLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKA 239
KLKEAEKQEEKQ +SGD ++ R E+R QRRSSVKKIEKMKEKRQAKYSENKLK KA
Sbjct: 180 KLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKA 239
Query: 240 RNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGL 299
RN+YLL L ATNA++ KYYIHD+SDLIDCCDLG+HASL R RTYLSAEYNLETSRHEGL
Sbjct: 240 RNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGL 299
Query: 300 DIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRY 359
D+IENAVDNL+ RSDK M+M FCPP+KFEFQ HMGDEVCQVSAQQPVQ EL++RY
Sbjct: 300 DVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRY 359
Query: 360 QQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETY 419
QLQSRLATLKIENEEV+KT +AT+QT+QDM+T+ED+DVS+ FQHSRSTESVKS SETY
Sbjct: 360 HQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETY 419
Query: 420 LSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTR 479
+SK +IAKRRANQQETE FYF K +EY+ GSNLITKLQAKHDLL++TLGEG RAE TTR
Sbjct: 420 MSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTR 479
Query: 480 PPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQG 539
R +R R+Q DSGQ IPL+VESCIR+INLYGLQ QG
Sbjct: 480 ---------GRRNARTRNQ---------------DSGQAIPLVVESCIRYINLYGLQQQG 515
Query: 540 IFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFND 599
IFRV GSQVEVNDIKNSFERGE+PL DDQ+ DINSVAGVLKLYFRGLENPLFPKERF D
Sbjct: 516 IFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQD 575
Query: 600 LISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICF 659
LIS I+++N ER I+++L+TLPR V++VMRYLFAFLNHLSQYSDENMMDPYNLAICF
Sbjct: 576 LISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICF 635
Query: 660 GPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMA-GDDYCDSP 718
GPTLM +P+ QD VSCQAH+NE+IKTIIIHHE IFP +EL+GPVYEKCMA G++YCDSP
Sbjct: 636 GPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSP 695
Query: 719 YSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASE 778
+SE G ++EVD D GTEPHTS++E E IEAIAKFDY+GRS RELSFKKGASLLLYHRASE
Sbjct: 696 HSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASE 755
Query: 779 DWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSK-DMNSPT 837
DWWEGRHNG+DGL+PHQYIVVQDMDD FSD+LSQKADSEASSGP+ +DK+SSK D+ SPT
Sbjct: 756 DWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPT 815
Query: 838 DRHPD----GYLARQRKRGEPPP-PVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLA-- 890
+ D G + R R R + P RR G D H PP L S+D + A
Sbjct: 816 EHISDYGFGGVMGRVRLRSDGAAIPRRRSG--GDTH---SPPRGL-GPSIDTPPRAAACP 869
Query: 891 SHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDH 950
S P + RG +SPE+RR GS +I+ D + +R + S +++ DH
Sbjct: 870 SSPHKIPLTRG-RIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDH 928
Query: 951 KPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLS 1010
K L+ E +A+DIE+TM+TAL+ELRELERQ+T K APDVVLDTLE +KN P P S+E S
Sbjct: 929 KSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGP-VSSEPAS 987
Query: 1011 PLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRM-GVQLKPPALRP-KPAVLPK--TN 1066
PLH + +R + +RRS+SSS++ M+TFKP ++ R+ G QL+PP +RP +P V + ++
Sbjct: 988 PLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSS 1047
Query: 1067 PTIGPAPPPQGPTDK 1081
+ G P PT+K
Sbjct: 1048 SSSGVGSPAVTPTEK 1062
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 1220 bits (3156), Expect = 0.0
Identities = 621/863 (71%), Positives = 717/863 (83%), Gaps = 40/863 (4%)
Query: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
M++P++FKKDKEIIAEY++QVKEIRAQL EQ KCL+QQ E+RVQLLQDLQDFFRKKAEIE
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
+YSRNLEKLAERF+AKTRSTKD QQ+KKDQN+LSPVNCW LLLNQV+RES+DH TLSDI
Sbjct: 61 MDYSRNLEKLAERFLAKTRSTKD-QQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDI 119
Query: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
YLNN+I RF+Q+SEDS R+FKKSKE+ QL +DLMKVLNELY+VMKTYHMY+A+SISA+S
Sbjct: 120 YLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQS 179
Query: 181 KLKEAEKQEEKQIG-----------RSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKY 229
KLKEAEKQEEKQIG RS D ++R+EE+H RRSSVKKIEKMKEKRQAKY
Sbjct: 180 KLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKY 239
Query: 230 SENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLID-CCDLGYHASLNRALRTYLSAE 288
+ENKLK+IKARNEYLL LEATNASVFKYYIHDLSDLID CCDLGYHASLNRALRT+LSAE
Sbjct: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
Query: 289 YNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQ 348
NLE S+HEGLD IENAV+NL+ SDKQR MEMY FCPPMKFEFQ HMGD Q+ AQ
Sbjct: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
Query: 349 QPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRST 408
QPVQ+EL+ R QQLQSRL+TLKIENEEVKKT EATLQTIQD+VT+ED+DVS+CFQ+S S
Sbjct: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
Query: 409 ESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLG 468
ESVKSTVSET++SKPSIAKRRANQQETEQFYF K++EYLEG NLITKLQAKHDLLQ+TLG
Sbjct: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
Query: 469 EGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIR 528
E R + R R S R Q DS Q IPL+VESCIR
Sbjct: 480 ESQRTDCSLAR-----------RSSTVRKQ---------------DSSQAIPLVVESCIR 513
Query: 529 FINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLE 588
FI+ +GLQH+GIFRVSGSQVEVNDIKN+FERGE+PLA DQ++HD++S+AGVLKLYFRGLE
Sbjct: 514 FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
Query: 589 NPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDEN 648
+PLFPK+ F+DL++C+ +DNL ERALHIRK+LL LP++ LI+MRYLFAFLNHLSQ+S+EN
Sbjct: 574 HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
Query: 649 MMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKC 708
MMDPYNLAICFGP+LM VPE DQVSCQAHVNE+IKTIII HE IFP +EL+GPVY +
Sbjct: 634 MMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRG 693
Query: 709 MAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGA 768
+ +DYCDSP+ E ++E+ QD E HTS+DECEPIEAIAKFDYVGR+ARELSFKKGA
Sbjct: 694 GSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGA 753
Query: 769 SLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKS 828
SLLLY RAS+DWWEGRHNGIDGL+PHQYIVVQD +D + S K++ E S P E +
Sbjct: 754 SLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVT 813
Query: 829 SSKDMNSPTDRH-PDGYLARQRK 850
+ + P+ H D YLA K
Sbjct: 814 ARAGASCPSGGHVADIYLANINK 836
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 784 bits (2025), Expect = 0.0
Identities = 394/806 (48%), Positives = 559/806 (69%), Gaps = 11/806 (1%)
Query: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
M+ + ++++ + AEYE+QVKE+R QL EQ +CLE Q E+R +LLQ+L +F R++AE+E
Sbjct: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
Query: 61 TEYSRNLEKLAERFMAK---TRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATL 117
EYSR LEKLAERF ++ S+++HQ ++K+ +LLSP++CW +LL R++S++ A L
Sbjct: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
Query: 118 SDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESIS 177
S++ + R I+ED R+ KKS+++ QL ++L++V++EL T KTY YH ES++
Sbjct: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
Query: 178 AESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSI 237
AE+KL+EAE+QEEK+ GRS E R+SS+KK ++ EKRQAK+ E+KLK
Sbjct: 181 AEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCT 240
Query: 238 KARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHE 297
KARNEYLL+L + NA+V YY+HD+ DL+DCCD G+H +L + LR+Y +AE + S+ +
Sbjct: 241 KARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQ 300
Query: 298 GLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELML 357
GL +E AV+ L+P DK + +E++ FCPP++F++ H GDEV ++ + ++ E++
Sbjct: 301 GLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILP 360
Query: 358 RYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSE 417
R Q +QSRL IE EEV KT +ATLQ + ++V +D DV + FQ S STES+KST S+
Sbjct: 361 RAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSD 420
Query: 418 TYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMT 477
+RR QQETE FY KL+EYL G +++ KLQAKH+ LQ L G + E
Sbjct: 421 P--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEV 478
Query: 478 TRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQH 537
+ K QK R+ RP SQYN +LF GD+E F++ SGQ +PL+VESCIRFINL GLQH
Sbjct: 479 SWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQH 538
Query: 538 QGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERF 597
+GIFRVSG+Q+ V++I+++FERGE+PL + + HD++SVAGVLKLYFR LE PLFP + F
Sbjct: 539 EGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLF 598
Query: 598 NDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAI 657
+L++ ++ ER H+ +LL LP VL+V+RYLF FLNHL+QYSDENMMDPYNLA+
Sbjct: 599 GELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAV 658
Query: 658 CFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYC-- 715
CFGPTL+PVP QD V+ Q VN++++T+I+ + +FP L GPVYEKCMA
Sbjct: 659 CFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCL 718
Query: 716 -DSPYSEHGTLEEVDQDAGTEPHTSEDECE-PIEAIAKFDYVGRSARELSFKKGASLLLY 773
D+ G E + +A E ED+ E +EA+A F Y GR+A+ELSF++G L L+
Sbjct: 719 GDAQLESLGADNEPELEA--EMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLH 776
Query: 774 HRASEDWWEGRHNGIDGLVPHQYIVV 799
RAS DWW G HNG+ GL+PH+YI +
Sbjct: 777 ERASSDWWRGEHNGMRGLIPHKYITL 802
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 121 bits (303), Expect = 4e-27
Identities = 69/215 (32%), Positives = 119/215 (55%), Gaps = 8/215 (3%)
Query: 488 QKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQ 547
+K++K+ PR+ + +L T Q +PLIV +C R + GL+ GI+RV G+
Sbjct: 799 KKNKKAAPRA-FGVRLEECQPAT----ENQRVPLIVAACCRIVEARGLESTGIYRVPGNN 853
Query: 548 VEVNDIKNSFERGENPL-ADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRI 606
V+ ++ RG + D+ D+N ++ +LK +FR L PLF +++ND I RI
Sbjct: 854 AVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRI 913
Query: 607 DNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPV 666
++ ER +RKL+ LP +++L L ++ +S++N M+P NLA+ FGPTL+
Sbjct: 914 EDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRT 973
Query: 667 PE--IQDQVSCQAHVNEIIKTIIIHHETIFPDAKE 699
E + D V+ +I++T+I H + F D ++
Sbjct: 974 SEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEED 1008
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 114 bits (286), Expect = 4e-25
Identities = 75/225 (33%), Positives = 122/225 (54%), Gaps = 16/225 (7%)
Query: 517 QVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSV 576
++ PL+VE C+ FI GL +G+FR+ G V D+++SF+ GE PL D S D+++V
Sbjct: 170 RLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFD--STTDVHTV 227
Query: 577 AGVLKLYFRGLENPLFPKERFNDLISCIRI--DNLYERALHIRKLLLTLPRSVLIVMRYL 634
A +LKLY R L P+ P R+ D +SC ++ + E L + K + LP++ ++RY+
Sbjct: 228 ASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYI 287
Query: 635 FAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQ---AHVNEIIKTIIIHHE 691
FL+ + YS+ N M NLA FGP ++ P+++D V+ + V ++ +I H
Sbjct: 288 CKFLDEVQAYSNVNKMSVQNLATVFGPNILR-PQVEDPVTIMEGTSLVQHLMTVLIRKHS 346
Query: 692 TIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEP 736
+F A +GP + G C + EEV +D+ EP
Sbjct: 347 QLF-TAPVPEGPTSPR---GGLQCAVGWGS----EEVTRDSQGEP 383
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 112 bits (279), Expect = 2e-24
Identities = 74/219 (33%), Positives = 113/219 (51%), Gaps = 10/219 (4%)
Query: 482 NVPPKPQKH--RKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQG 539
NV + KH +P + K++ DL T VK P++V+ CIR I GL+ +G
Sbjct: 251 NVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEG 310
Query: 540 IFRVSGSQVEVNDIKNSFERGENPLADDQSN--HDINSVAGVLKLYFRGLENPLFPKERF 597
++RVSG + D+K +F+R + AD +N DIN + G LKLYFR L P+ + +
Sbjct: 311 LYRVSGFTEHIEDVKMAFDR-DGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTY 369
Query: 598 NDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAI 657
+ I +I N ER + ++L+ LP + +RYL L ++ +N M+ NL I
Sbjct: 370 SKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGI 429
Query: 658 CFGPTLMPVPEIQDQVSCQAH---VNEIIKTIIIHHETI 693
FGPTLM PE D H ++I I+I +E +
Sbjct: 430 VFGPTLMRPPE--DSTLTTLHDMRYQKLIVQILIENEDV 466
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 112 bits (279), Expect = 2e-24
Identities = 74/219 (33%), Positives = 113/219 (51%), Gaps = 10/219 (4%)
Query: 482 NVPPKPQKH--RKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQG 539
NV + KH +P + K++ DL T VK P++V+ CIR I GL+ +G
Sbjct: 115 NVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEG 174
Query: 540 IFRVSGSQVEVNDIKNSFERGENPLADDQSN--HDINSVAGVLKLYFRGLENPLFPKERF 597
++RVSG + D+K +F+R + AD +N DIN + G LKLYFR L P+ + +
Sbjct: 175 LYRVSGFTEHIEDVKMAFDR-DGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTY 233
Query: 598 NDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAI 657
+ I +I N ER + ++L+ LP + +RYL L ++ +N M+ NL I
Sbjct: 234 SKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGI 293
Query: 658 CFGPTLMPVPEIQDQVSCQAH---VNEIIKTIIIHHETI 693
FGPTLM PE D H ++I I+I +E +
Sbjct: 294 VFGPTLMRPPE--DSTLTTLHDMRYQKLIVQILIENEDV 330
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 111 bits (278), Expect = 3e-24
Identities = 66/220 (30%), Positives = 120/220 (54%), Gaps = 12/220 (5%)
Query: 490 HRKSRPRSQYNTKLFNGDLETFVKDS----GQVIPLIVESCIRFINLYGLQHQGIFRVSG 545
+R+ + + +F LE V+ ++ P++VE C+ FI GL+ +G+FR+ G
Sbjct: 26 YRRIKRCFSFRKGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPG 85
Query: 546 SQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIR 605
V +++++F+ GE P D SN D+++VA +LKLY R L P+ P ++ D +SC +
Sbjct: 86 QANLVKELQDAFDCGEKPSFD--SNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAK 143
Query: 606 IDNLYERA--LHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTL 663
+ + E A + K + +LP +++Y+ FL+ + YS N M NLA FGP +
Sbjct: 144 LLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNI 203
Query: 664 MPVPEIQDQVSCQ---AHVNEIIKTIIIHHETIFPDAKEL 700
+ P+++D ++ V +++ +I H+ +FP EL
Sbjct: 204 LR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAEL 242
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 111 bits (277), Expect = 4e-24
Identities = 61/189 (32%), Positives = 109/189 (57%), Gaps = 8/189 (4%)
Query: 517 QVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSV 576
++ P++VE C+ FI GL+ +G+FR+ G V +++++F+ GE P D SN D+++V
Sbjct: 55 RLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD--SNTDVHTV 112
Query: 577 AGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERA--LHIRKLLLTLPRSVLIVMRYL 634
A +LKLY R L P+ P ++ D +SC ++ + E A + K + +LP +++Y+
Sbjct: 113 ASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYI 172
Query: 635 FAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQ---AHVNEIIKTIIIHHE 691
FL+ + YS N M NLA FGP ++ P+++D ++ V +++ +I H+
Sbjct: 173 CRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHD 231
Query: 692 TIFPDAKEL 700
+FP EL
Sbjct: 232 CLFPKDAEL 240
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 111 bits (277), Expect = 4e-24
Identities = 61/189 (32%), Positives = 109/189 (57%), Gaps = 8/189 (4%)
Query: 517 QVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSV 576
++ P++VE C+ FI GL+ +G+FR+ G V +++++F+ GE P D SN D+++V
Sbjct: 150 RLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD--SNTDVHTV 207
Query: 577 AGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERA--LHIRKLLLTLPRSVLIVMRYL 634
A +LKLY R L P+ P ++ D +SC ++ + E A + K + +LP +++Y+
Sbjct: 208 ASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYI 267
Query: 635 FAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQ---AHVNEIIKTIIIHHE 691
FL+ + YS N M NLA FGP ++ P+++D ++ V +++ +I H+
Sbjct: 268 CRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHD 326
Query: 692 TIFPDAKEL 700
+FP EL
Sbjct: 327 CLFPKDAEL 335
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 109 bits (272), Expect = 2e-23
Identities = 67/202 (33%), Positives = 105/202 (51%), Gaps = 2/202 (0%)
Query: 494 RPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDI 553
+P ++ K+++ DL T VK P++V+ CIR I GL +G++RVSG + D+
Sbjct: 256 KPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDV 315
Query: 554 KNSFER-GENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYER 612
K +F+R GE DIN + G LKLYFR L PL + + I +I + E+
Sbjct: 316 KMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQ 375
Query: 613 ALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQ 672
+ + L LP + +RYL A L ++ + EN+M+ NL I FGPTLM PE+
Sbjct: 376 LETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM 435
Query: 673 VSC-QAHVNEIIKTIIIHHETI 693
+ ++ ++I +E I
Sbjct: 436 AALNDIRYQRLVVELLIKNEDI 457
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 109 bits (272), Expect = 2e-23
Identities = 67/202 (33%), Positives = 105/202 (51%), Gaps = 2/202 (0%)
Query: 494 RPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDI 553
+P ++ K+++ DL T VK P++V+ CIR I GL +G++RVSG + D+
Sbjct: 230 KPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDV 289
Query: 554 KNSFER-GENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYER 612
K +F+R GE DIN + G LKLYFR L PL + + I +I + E+
Sbjct: 290 KMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQ 349
Query: 613 ALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQ 672
+ + L LP + +RYL A L ++ + EN+M+ NL I FGPTLM PE+
Sbjct: 350 LETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAM 409
Query: 673 VSC-QAHVNEIIKTIIIHHETI 693
+ ++ ++I +E I
Sbjct: 410 AALNDIRYQRLVVELLIKNEDI 431
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 106 bits (264), Expect = 1e-22
Identities = 71/269 (26%), Positives = 132/269 (49%), Gaps = 19/269 (7%)
Query: 441 MKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPK---------PQKHR 491
+ +R+ L G+ K Q+ H + + + ++ PPK P R
Sbjct: 1079 LSIRQTLLGAKSEPKTQSPHSPKEES------ERKLLSKDDTSPPKDKGTWRKGIPSIMR 1132
Query: 492 KSRPRSQYNTKLFNGDLETFVK-DSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEV 550
K+ + T F L+ + + IPLIV+ C + + GL++ GI+RV G+ +
Sbjct: 1133 KTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAI 1192
Query: 551 NDIKNSFERGENPL-ADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNL 609
+ ++ +G + D D+N ++ +LK +FR L PLF +++ D I R ++
Sbjct: 1193 SSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDP 1252
Query: 610 YERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPE- 668
+R +++L+ LP +++L A L +++ S++N M+P NLAI FGPTL+ E
Sbjct: 1253 LDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSED 1312
Query: 669 -IQDQVSCQAHVNEIIKTIIIHHETIFPD 696
+ V+ +I++T+I HH+ F +
Sbjct: 1313 NMTHMVTHMPDQYKIVETLIQHHDWFFTE 1341
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 103 bits (256), Expect = 1e-21
Identities = 131/595 (22%), Positives = 223/595 (37%), Gaps = 48/595 (8%)
Query: 504 FNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENP 563
F LE +K SG+ I L +E+C+ + G++ +G+FR+ ++ +K + + +
Sbjct: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
Query: 564 LADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTL 623
L D+ D ++VAG LK Y R L PL + + + + ++ + + L
Sbjct: 310 L--DEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKL 367
Query: 624 PRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPE----IQDQVSCQAHV 679
P + RYL FL L+Q SD N M P N+AI GP L+ + + HV
Sbjct: 368 PPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHV 427
Query: 680 NEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTS 739
+I+ II H + FP+ E + V E + +P S H D D+GT
Sbjct: 428 VAVIEPIIQHADWFFPEEVEFN--VSEAFVP----LTTPSSNHSFHTGNDSDSGTLERKR 481
Query: 740 EDECEPIEA-IAKFDYVGRSAREL-SFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYI 797
+E + K + G + + ++G +L H + ++ DG
Sbjct: 482 PASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPA--FQPPLPPTDGST----- 534
Query: 798 VVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPP 857
VV + S +A+S + G V + SP D P + P P
Sbjct: 535 VVPAGPEP--PPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPK--PKDPVSAAVPAP 590
Query: 858 VRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRR------ 911
R + + G P A + + +G P A+ P R + +P +
Sbjct: 591 GRNNSQIASGQN--QPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPP 648
Query: 912 -RPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTAL 970
PG S + S+H PP R + Q+TG +P P ++ +
Sbjct: 649 GHPGGQSSSGTSQHPPSLS-PKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYS----- 702
Query: 971 NELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSS 1030
+ L ++ + P L K + + +L H + S P + S
Sbjct: 703 SSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPS 762
Query: 1031 SSDTMSTFKPMVAPRMGVQLKPPAL--------RPKPAVLPKTNPTIGPAPPPQG 1077
+ + AP+ P RP+P P+ P++ P P P G
Sbjct: 763 TPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPG 817
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 101 bits (252), Expect = 3e-21
Identities = 63/217 (29%), Positives = 112/217 (51%), Gaps = 10/217 (4%)
Query: 448 EGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGD 507
+G N + + D +R + R T+ P P+P S ++ + + F
Sbjct: 1199 KGDNAVIPYETDEDPRRRNILRSLRRN---TKKPKPKPRP-----SITKATWESNYFGVP 1250
Query: 508 LETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADD 567
L T V + IP+ +E CI +I GL +GI+RVSG++ E+ ++ F++ N L
Sbjct: 1251 LTTVVTPE-KPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHN-LDLA 1308
Query: 568 QSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSV 627
+ + +N+VAG +K +F L +PL P DL+ +I++ ++ ++++L P+
Sbjct: 1309 EKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKEN 1368
Query: 628 LIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLM 664
V +Y+ + LN +S + N+M NL+ICF PTLM
Sbjct: 1369 HEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLM 1405
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 100 bits (250), Expect = 6e-21
Identities = 58/204 (28%), Positives = 102/204 (50%), Gaps = 3/204 (1%)
Query: 494 RPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDI 553
R + ++F L + +P V+ CIR + GL G++R+SG+ + +
Sbjct: 317 REKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKL 376
Query: 554 KNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERA 613
+ + E DD D++ + G LKL+FR L PLFP F I+ I++ + R+
Sbjct: 377 RYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRS 436
Query: 614 LHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQV 673
+R L+ +LP +R LF L + ++ ++N M ++AI FGPTL+ PE+++
Sbjct: 437 RCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETS 495
Query: 674 SCQAHV--NEIIKTIIIHHETIFP 695
V N++++ I+ IFP
Sbjct: 496 MPMTMVFQNQVVELILQQCADIFP 519
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 100 bits (250), Expect = 6e-21
Identities = 58/204 (28%), Positives = 102/204 (50%), Gaps = 3/204 (1%)
Query: 494 RPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDI 553
R + ++F L + +P V+ CIR + GL G++R+SG+ + +
Sbjct: 344 REKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKL 403
Query: 554 KNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERA 613
+ + E DD D++ + G LKL+FR L PLFP F I+ I++ + R+
Sbjct: 404 RYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRS 463
Query: 614 LHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQV 673
+R L+ +LP +R LF L + ++ ++N M ++AI FGPTL+ PE+++
Sbjct: 464 RCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR-PEVEETS 522
Query: 674 SCQAHV--NEIIKTIIIHHETIFP 695
V N++++ I+ IFP
Sbjct: 523 MPMTMVFQNQVVELILQQCADIFP 546
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 99.8 bits (247), Expect = 1e-20
Identities = 78/321 (24%), Positives = 147/321 (45%), Gaps = 23/321 (7%)
Query: 375 EVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQE 434
+ ++ TE +Q+ D V + + V ++++ E+ + + E P I K + +E
Sbjct: 546 KTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEG-IEEEIPDSPGIEK---HDKE 601
Query: 435 TEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSR 494
EQ KLR + S D ++ + + +++T RP + R
Sbjct: 602 KEQKDPKKLRSFKVSSI---------DSSEQKKTKKNLKKFLTRRPTL--------QAVR 644
Query: 495 PRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIK 554
+ ++F +L + +P V+ CI + +GL GI+RVSG+ + ++
Sbjct: 645 EKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLR 704
Query: 555 NSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERAL 614
+ E +D DI+ + G LK++FR L PLF FND ++ I+ +R
Sbjct: 705 FAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIK-QEPRQRVA 763
Query: 615 HIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLM-PVPEIQDQV 673
++ L+ LP+ M+ LF L + + ++N M ++AI FGPTL+ P E +
Sbjct: 764 AVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIA 823
Query: 674 SCQAHVNEIIKTIIIHHETIF 694
+ N+I++ I++ +IF
Sbjct: 824 VHTVYQNQIVELILLELSSIF 844
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 97.4 bits (241), Expect = 6e-20
Identities = 132/579 (22%), Positives = 215/579 (37%), Gaps = 94/579 (16%)
Query: 504 FNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENP 563
F LE +K SG+ I L +E+C+ + G++ +G+FR+ ++ +K + + +
Sbjct: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
Query: 564 LADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTL 623
L D+ D ++VAG LK Y R L PL + + + + ++ + + L
Sbjct: 310 L--DEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKL 367
Query: 624 PRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPE----IQDQVSCQAHV 679
P + RYL FL L+Q SD N M P N+AI GP L+ + + HV
Sbjct: 368 PPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHV 427
Query: 680 NEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTS 739
+I+ II H + FP+ E++ V E + +P S H D D+GT
Sbjct: 428 VAVIEPIIQHADWFFPE--EVEFNVSEAFVP----LTTPSSNHSFHTGNDSDSGTLERKR 481
Query: 740 EDECEPIEA-IAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIV 798
+E + K + + +S A GR+N
Sbjct: 482 PASMAVMEGDLVKKESPPKPKDPVSAAVPA-------------PGRNN------------ 516
Query: 799 VQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPV 858
S S + +A++G S M P + +R +P P
Sbjct: 517 --------SQIASGQNQPQAAAG------SHQLSMGQPHNAAGPSPHTLRRAVKKPAPAP 562
Query: 859 RRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRRRPGHGSL 918
+PG GH P S+S PSL+ P R + + + PG S
Sbjct: 563 PKPGNPPPGH-----PGGQSSSGTSQHPPSLSPKP----PTRSPSPPTQHTGQPPGQPSA 613
Query: 919 TNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELER 978
+ ++ +P RR +SS +H P P T A + T + +
Sbjct: 614 PS--------QLSAP--RRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMAL 663
Query: 979 QSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTF 1038
S +H LEQ ++P P T T +P L P + + + T
Sbjct: 664 PS--EHG-------LEQPSHTP-PQTPTPPSTP----PLGKQNPSLPAPQTLAGGNPETA 709
Query: 1039 KPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQG 1077
+P RP+P P+ P++ P P P G
Sbjct: 710 QPHAG---------TLPRPRPVPKPRNRPSVPPPPQPPG 739
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 96.7 bits (239), Expect = 1e-19
Identities = 55/180 (30%), Positives = 91/180 (50%)
Query: 494 RPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDI 553
R S+ T +F + K +P IV C+ I G++ GI+RVSG ++ +
Sbjct: 998 RMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQAL 1057
Query: 554 KNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERA 613
K +F+ ++ S D+N++AG LKLYFR L PLF E + + I + + +
Sbjct: 1058 KAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKE 1117
Query: 614 LHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQV 673
+ LLL+LP + L+ +L L +++ N M +NLA FGPTL+ E + ++
Sbjct: 1118 SCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKL 1177
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 96.7 bits (239), Expect = 1e-19
Identities = 55/180 (30%), Positives = 91/180 (50%)
Query: 494 RPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDI 553
R S+ T +F + K +P IV C+ I G++ GI+RVSG ++ +
Sbjct: 1042 RMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQAL 1101
Query: 554 KNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERA 613
K +F+ ++ S D+N++AG LKLYFR L PLF E + + I + + +
Sbjct: 1102 KAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKE 1161
Query: 614 LHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQV 673
+ LLL+LP + L+ +L L +++ N M +NLA FGPTL+ E + ++
Sbjct: 1162 SCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKL 1221
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 92.8 bits (229), Expect = 2e-18
Identities = 62/208 (29%), Positives = 104/208 (50%), Gaps = 11/208 (5%)
Query: 486 KPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSG 545
K K+ R + + F L+ V + + IPL VE C+ FI GL +G++RVSG
Sbjct: 1242 KKTKNFNPPTRRNWESNYFGMPLQDLVT-AEKPIPLFVEKCVEFIEDTGLCTEGLYRVSG 1300
Query: 546 SQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIR 605
++ + ++I+ F++ N + +N+VAG LK +F L +PL P +L+ +
Sbjct: 1301 NKTDQDNIQKQFDQDHN-INLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAK 1359
Query: 606 IDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMP 665
I + ER +++++ V RY+ LN +SQ N+M NL+ICF PTLM
Sbjct: 1360 IPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMR 1419
Query: 666 VPEIQDQVSCQAHVNEIIKTIIIHHETI 693
P+ +++ E + T IH +
Sbjct: 1420 -PDFENR--------EFLSTTKIHQSVV 1438
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 92.8 bits (229), Expect = 2e-18
Identities = 62/208 (29%), Positives = 104/208 (50%), Gaps = 11/208 (5%)
Query: 486 KPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSG 545
K K+ R + + F L+ V + + IPL VE C+ FI GL +G++RVSG
Sbjct: 1241 KKTKNFNPPTRRNWESNYFGMPLQDLVT-AEKPIPLFVEKCVEFIEDTGLCTEGLYRVSG 1299
Query: 546 SQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIR 605
++ + ++I+ F++ N + +N+VAG LK +F L +PL P +L+ +
Sbjct: 1300 NKTDQDNIQKQFDQDHN-INLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAK 1358
Query: 606 IDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMP 665
I + ER +++++ V RY+ LN +SQ N+M NL+ICF PTLM
Sbjct: 1359 IPDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMR 1418
Query: 666 VPEIQDQVSCQAHVNEIIKTIIIHHETI 693
P+ +++ E + T IH +
Sbjct: 1419 -PDFENR--------EFLSTTKIHQSVV 1437
>gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]
Length = 439
Score = 90.5 bits (223), Expect = 8e-18
Identities = 60/219 (27%), Positives = 105/219 (47%), Gaps = 6/219 (2%)
Query: 477 TTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQ 536
T + P PKP R P Q+ L + + + IP+++ + ++ + L
Sbjct: 220 TQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKN---PEQEPIPIVLRETVAYLQAHALT 276
Query: 537 HQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKER 596
+GIFR S + V +++ + G P+ DQ N +++ A +LK + R L PL +
Sbjct: 277 TEGIFRRSANTQVVREVQQKYNMGL-PVDFDQYN-ELHLPAVILKTFLRELPEPLLTFDL 334
Query: 597 FNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLA 656
+ ++ + ID +R ++L TLP V+R+L AFL +S +SD+N M NLA
Sbjct: 335 YPHVVGFLNIDES-QRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLA 393
Query: 657 ICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFP 695
+ FGP L+ + + +N K ++ H +FP
Sbjct: 394 VVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFP 432
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 90.1 bits (222), Expect = 1e-17
Identities = 54/194 (27%), Positives = 89/194 (45%), Gaps = 1/194 (0%)
Query: 502 KLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGE 561
++F L + +P V+ CI + GL GI+RVSG+ + ++ + E
Sbjct: 277 QIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEE 336
Query: 562 NPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLL 621
DD DI+ V G LK++FR L PLFP F + I+ + R ++ L+
Sbjct: 337 KLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQ 396
Query: 622 TLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVP-EIQDQVSCQAHVN 680
LP M+ LF L + + +N+M +L I FGPTL+ E + + N
Sbjct: 397 KLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQN 456
Query: 681 EIIKTIIIHHETIF 694
+I + ++ + IF
Sbjct: 457 QIAELMLSEYSKIF 470
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 89.7 bits (221), Expect = 1e-17
Identities = 52/179 (29%), Positives = 86/179 (48%)
Query: 494 RPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDI 553
R S+ T +F + K +P IV C+ + G++ GI+R+SG ++ +
Sbjct: 589 RTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQAL 648
Query: 554 KNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERA 613
K F+ + S+ DIN++AG LKLYFR L PL + + I + + +
Sbjct: 649 KAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKE 708
Query: 614 LHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQ 672
+ LL +LP LI +L L +++ N M +NLA FGPTL+ E++ +
Sbjct: 709 NCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESK 767
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 89.7 bits (221), Expect = 1e-17
Identities = 52/179 (29%), Positives = 86/179 (48%)
Query: 494 RPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDI 553
R S+ T +F + K +P IV C+ + G++ GI+R+SG ++ +
Sbjct: 635 RTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQAL 694
Query: 554 KNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERA 613
K F+ + S+ DIN++AG LKLYFR L PL + + I + + +
Sbjct: 695 KAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKE 754
Query: 614 LHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQ 672
+ LL +LP LI +L L +++ N M +NLA FGPTL+ E++ +
Sbjct: 755 NCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESK 813
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,659,134
Number of Sequences: 37866
Number of extensions: 2086797
Number of successful extensions: 14752
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 273
Number of HSP's successfully gapped in prelim test: 522
Number of HSP's that attempted gapping in prelim test: 12509
Number of HSP's gapped (non-prelim): 2553
length of query: 1085
length of database: 18,247,518
effective HSP length: 113
effective length of query: 972
effective length of database: 13,968,660
effective search space: 13577537520
effective search space used: 13577537520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.