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Search of human proteins with 44680133
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor
[Homo sapiens]
(343 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 691 0.0
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 691 0.0
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 691 0.0
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 193 2e-49
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 189 4e-48
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 188 5e-48
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 188 5e-48
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 188 5e-48
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 188 5e-48
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 182 5e-46
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 170 1e-42
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 168 6e-42
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi... 162 3e-40
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 93 4e-19
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 91 1e-18
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 87 2e-17
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 82 9e-16
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 74 1e-13
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 70 4e-12
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 69 5e-12
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 67 2e-11
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 67 3e-11
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 59 5e-09
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 59 6e-09
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 58 1e-08
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 57 3e-08
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 57 3e-08
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 56 4e-08
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 56 4e-08
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 55 9e-08
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 691 bits (1783), Expect = 0.0
Identities = 343/343 (100%), Positives = 343/343 (100%)
Query: 1 MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV
Sbjct: 1 MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
Query: 61 TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV
Sbjct: 61 TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
Query: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL
Sbjct: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
Query: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN
Sbjct: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
Query: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
Sbjct: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
Query: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR
Sbjct: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 691 bits (1783), Expect = 0.0
Identities = 343/343 (100%), Positives = 343/343 (100%)
Query: 1 MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV
Sbjct: 1 MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
Query: 61 TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV
Sbjct: 61 TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
Query: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL
Sbjct: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
Query: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN
Sbjct: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
Query: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
Sbjct: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
Query: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR
Sbjct: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 691 bits (1783), Expect = 0.0
Identities = 343/343 (100%), Positives = 343/343 (100%)
Query: 1 MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV
Sbjct: 1 MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
Query: 61 TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV
Sbjct: 61 TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
Query: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL
Sbjct: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
Query: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN
Sbjct: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
Query: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
Sbjct: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
Query: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR
Sbjct: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 193 bits (491), Expect = 2e-49
Identities = 117/291 (40%), Positives = 173/291 (59%), Gaps = 15/291 (5%)
Query: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
K V +TGCDSGFG LA+ L ++G V A CL + G ++L SDRL TV L+V
Sbjct: 30 KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85
Query: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174
E + + V+ + D +G+WGLVNNAGI T E+ + E + +VNL G ++
Sbjct: 86 KMESIAAATQWVKEHVGD--RGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQ 143
Query: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
+T S LPL+RRA+GR+VN+SS+LGR+A YC++K+GVEAFSD LR E+ GVK+S
Sbjct: 144 VTLSMLPLVRRARGRIVNVSSILGRVAFFV-GGYCVSKYGVEAFSDILRREIQHFGVKIS 202
Query: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTD 294
+VEPG F T + + K+ W+E P+ +++ YG++YFD M+ + ST+
Sbjct: 203 IVEPGYF--RTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTN 260
Query: 295 TSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQI--MTHLPGAISDMIYIR 343
+ V D + HALT+ P TRY W + +++LP +++D I R
Sbjct: 261 LNLVTDCMEHALTSVHPRTRY---SAGWDAKFFFIPLSYLPTSLADYILTR 308
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 189 bits (479), Expect = 4e-48
Identities = 105/266 (39%), Positives = 159/266 (59%), Gaps = 10/266 (3%)
Query: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQL 112
+ K V +TGCDSGFG LAK L +G V A C ++ G ++L S RL+T L
Sbjct: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE----GSQKLQRDTSYRLQTTLL 78
Query: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWG 171
+V SE ++ + VR K E+G+W LVNNAG+ G E+ + + + +V VNL G
Sbjct: 79 DVTKSESIKAAAQWVRD--KVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVG 136
Query: 172 TVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGV 231
+ +T LP+++RA+GRVVN+SS GR+A YC++KFGVEAFSD +R E+Y GV
Sbjct: 137 LIEVTLHMLPMVKRARGRVVNMSSSGGRVA-VIGGGYCVSKFGVEAFSDSIRRELYYFGV 195
Query: 232 KVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSG 291
KV ++EPGN+ T++ E++++ +K+WE LP+ R YG+ YF K++
Sbjct: 196 KVCIIEPGNY--RTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVA 253
Query: 292 STDTSPVIDAVTHALTATTPYTRYHP 317
VI+++ HA+ + +P RY+P
Sbjct: 254 EPRVRDVINSMEHAIVSRSPRIRYNP 279
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 188 bits (478), Expect = 5e-48
Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)
Query: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
E + K + +TGCDSGFG A+ KGF V A CL + G L + S+RLRTV
Sbjct: 25 EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
L+V E V++ + V++ + EKG+WGL+NNAG+ ++ +LE Y++ EVNL
Sbjct: 81 LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
Query: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
+G + +T + LPL+++A+GRV+N+SS+ GR+A Y +K+ VE F+D LR +M
Sbjct: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
GV VS +EPG F T+L P ++ I KK+ WE+L +++ YG+ Y ++ + K++
Sbjct: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
S + D SPV++ + HALT+ P T Y +W+ ++H+P A+ D + ++
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 188 bits (478), Expect = 5e-48
Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)
Query: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
E + K + +TGCDSGFG A+ KGF V A CL + G L + S+RLRTV
Sbjct: 25 EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
L+V E V++ + V++ + EKG+WGL+NNAG+ ++ +LE Y++ EVNL
Sbjct: 81 LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
Query: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
+G + +T + LPL+++A+GRV+N+SS+ GR+A Y +K+ VE F+D LR +M
Sbjct: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
GV VS +EPG F T+L P ++ I KK+ WE+L +++ YG+ Y ++ + K++
Sbjct: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
S + D SPV++ + HALT+ P T Y +W+ ++H+P A+ D + ++
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 188 bits (478), Expect = 5e-48
Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)
Query: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
E + K + +TGCDSGFG A+ KGF V A CL + G L + S+RLRTV
Sbjct: 25 EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
L+V E V++ + V++ + EKG+WGL+NNAG+ ++ +LE Y++ EVNL
Sbjct: 81 LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
Query: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
+G + +T + LPL+++A+GRV+N+SS+ GR+A Y +K+ VE F+D LR +M
Sbjct: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
GV VS +EPG F T+L P ++ I KK+ WE+L +++ YG+ Y ++ + K++
Sbjct: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
S + D SPV++ + HALT+ P T Y +W+ ++H+P A+ D + ++
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 188 bits (478), Expect = 5e-48
Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)
Query: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
E + K + +TGCDSGFG A+ KGF V A CL + G L + S+RLRTV
Sbjct: 25 EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
L+V E V++ + V++ + EKG+WGL+NNAG+ ++ +LE Y++ EVNL
Sbjct: 81 LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
Query: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
+G + +T + LPL+++A+GRV+N+SS+ GR+A Y +K+ VE F+D LR +M
Sbjct: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
GV VS +EPG F T+L P ++ I KK+ WE+L +++ YG+ Y ++ + K++
Sbjct: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
S + D SPV++ + HALT+ P T Y +W+ ++H+P A+ D + ++
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 182 bits (461), Expect = 5e-46
Identities = 110/264 (41%), Positives = 159/264 (60%), Gaps = 16/264 (6%)
Query: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
K V +TGCDSGFG LA+ L ++G V A CL + G ++L SDRL TV L+V
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85
Query: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174
+E V + V+ ++D KG+WGLVNNAGIS E + + + + +VNL G +
Sbjct: 86 KTESVAAAAQWVKECVRD--KGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVID 143
Query: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
+T S LPL+RRA+GRVVN+SS++GR+ + YCI+K+GVEAFSD LR E+ GVKV+
Sbjct: 144 VTLSLLPLVRRARGRVVNVSSVMGRV-SLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
Query: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKY---FDEKIAKMETYCSSG 291
++EPG F T++ S E ++W+ V++ YG+K+ + + +ME C+
Sbjct: 203 MIEPGYF--KTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQ- 259
Query: 292 STDTSPVIDAVTHALTATTPYTRY 315
D S V + + HAL A P TRY
Sbjct: 260 --DLSLVTNCMEHALIACHPRTRY 281
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 170 bits (431), Expect = 1e-42
Identities = 102/271 (37%), Positives = 153/271 (56%), Gaps = 17/271 (6%)
Query: 52 PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
P + V +TGCDSGFG LA L +GF V A CL G ++L + S RL T
Sbjct: 25 PASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPS----GAEDLQRVASSRLHTTL 80
Query: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
L++ + V++ + V +K E G++GLVNNAG++ G + + + +++V VN
Sbjct: 81 LDITDPQSVQQAAKWVEMHVK--EAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTM 138
Query: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
G + +T + LPL+++A+GRV+NI+S+LGR+A YC++KFG+EAFSD LR ++ G
Sbjct: 139 GPIGVTLALLPLLQQARGRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVAHFG 197
Query: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYG----KKYFDEKIAKMET 286
++VS+VEPG F T + + ES++ + W LP + YG KY + M
Sbjct: 198 IRVSIVEPGFF--RTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNL 255
Query: 287 YCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
C T S ++ HALTA P TRY P
Sbjct: 256 ICDPDLTKVSRCLE---HALTARHPRTRYSP 283
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 168 bits (426), Expect = 6e-42
Identities = 107/287 (37%), Positives = 160/287 (55%), Gaps = 15/287 (5%)
Query: 45 TYASAAE--PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSL 102
TY S E PV KAVLVTG D G G +L K+L GF VFAG L ++ G +EL
Sbjct: 70 TYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL--NENGPGAEELRRT 127
Query: 103 NSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFG-EVEFTSLETY 161
S RL +Q+++ +++ V + L+D +G+W ++NNAG+ F + E + Y
Sbjct: 128 CSPRLSVLQMDITKPVQIKDAYSKVAAMLQD--RGLWAVINNAGVLGFPTDGELLLMTDY 185
Query: 162 KQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC 221
KQ VN +GTV +TK+FLPL+R++KGR+VN+SSM G + Y +K V FS
Sbjct: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245
Query: 222 LRYEMYPLGVKVSVVEPGNF---IAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFD 278
+R E+ G+KV+ ++PG F IA TS + + + K + + LP V++DYG+ Y
Sbjct: 246 MRLELSKWGIKVASIQPGGFLTNIAGTS----DKWEKLEKDILDHLPAEVQEDYGQDYIL 301
Query: 279 EKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP-MDYYWWL 324
+ + S S D SPV+ + HA+ A +P+ Y P Y W+
Sbjct: 302 AQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWI 348
>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
Length = 405
Score = 162 bits (411), Expect = 3e-40
Identities = 97/275 (35%), Positives = 147/275 (53%), Gaps = 22/275 (8%)
Query: 52 PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
PV ++AVL+TGCDSGFG AK L S GF V A L + G EL + S RLR +Q
Sbjct: 79 PVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVL--ELNSPGAIELRTCCSPRLRLLQ 136
Query: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
+++ ++ +V+E ++ G+WGLVNNAG + + E + + T++ EVN +
Sbjct: 137 MDLTKPGDISRVLEFTKAHTTST--GLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFF 194
Query: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
G + +TK LPL+R ++GR+V + S G M P Y +K V D E+ P G
Sbjct: 195 GALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWG 254
Query: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEE--------LPEVVRKDYGKKYFDEKIA 282
VKVS+++PG F ES++ + + WE+ LP+ + + YGK Y +
Sbjct: 255 VKVSIIQPGCF-------KTESVRNVGQ--WEKRKQLLLANLPQELLQAYGKDYIEHLHG 305
Query: 283 KMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
+ +D +PV+DA+T AL A P RY+P
Sbjct: 306 QFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYP 340
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 92.8 bits (229), Expect = 4e-19
Identities = 77/267 (28%), Positives = 123/267 (46%), Gaps = 26/267 (9%)
Query: 56 KAVLVTGCDSGFGFSLA---KHLHSKGFLVFAGCLMKDKGHDGVKELDSLNS--DRLRTV 110
+ VL++GC SG G LA H K + V A M+D G E + + L
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVA--TMRDLGKKETLEAAAGEALGQTLTVA 63
Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLW 170
QL+VCS E V + + ++ + LVNNAG+ G +E SL + V + N +
Sbjct: 64 QLDVCSDESVAQCLSCIQGEVDV-------LVNNAGMGLVGPLEGLSLAAMQNVFDTNFF 116
Query: 171 GTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
G VR+ K+ LP + RR +G +V ISS++G Y +KF +E F + L ++
Sbjct: 117 GAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQF 176
Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKI--AKMETY 287
+ +S+VEPG + T Q + PE + YF + A + +
Sbjct: 177 NIFISLVEPGPVV--TEFEGKLLAQVSMAEFPGTDPETLH------YFRDLYLPASRKLF 228
Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTR 314
CS G + V+ A+ + +++T P R
Sbjct: 229 CSVGQ-NPQDVVQAIVNVISSTRPPLR 254
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 90.9 bits (224), Expect = 1e-18
Identities = 62/187 (33%), Positives = 107/187 (57%), Gaps = 8/187 (4%)
Query: 58 VLVTGCDSGFGFSLAKHLHSKGF-LVFAGCLMKDKG--HDGVKELDSLNSDRLRTVQLNV 114
V++TG SG G AK ++ G LV G ++ G + ++EL + ++ +++T + +
Sbjct: 55 VVITGATSGLGKECAKVFYAAGAKLVLCG---RNGGALEELIRELTASHATKVQTHKPYL 111
Query: 115 CSSEEVEK-VVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTV 173
+ + + + + + + LVNNAGIS G + T+++ K+V E N +G V
Sbjct: 112 VTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPV 171
Query: 174 RMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVK 232
+TK+ LP +I+R +G +V ISS+ G+M+ P RS Y +K +AF DCLR EM ++
Sbjct: 172 ALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIE 231
Query: 233 VSVVEPG 239
V+V+ PG
Sbjct: 232 VTVISPG 238
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/206 (34%), Positives = 101/206 (49%), Gaps = 17/206 (8%)
Query: 58 VLVTGCDSGFGFSLAKHLHS---KGFLVFAGCL-MKDKGH--DGVKELDSLNSDRLRTVQ 111
VL+TGC SG G LA L S + F V+A +K +G + + L + L T+Q
Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARAL-ACPPGSLETLQ 64
Query: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWG 171
L+V S+ V E V D LV NAG+ G +E + V +VN+ G
Sbjct: 65 LDVRDSKSVAAARERVTEGRVDV------LVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
Query: 172 TVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
TVRM ++FLP + RR GRV+ S+ G M P YC +KF +E + L + P G
Sbjct: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
Query: 231 VKVSVVEPGNFIAA---TSLYSPESI 253
V +S++E G A L SPE +
Sbjct: 179 VHLSLIECGPVHTAFMEKVLGSPEEV 204
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 81.6 bits (200), Expect = 9e-16
Identities = 62/210 (29%), Positives = 104/210 (49%), Gaps = 25/210 (11%)
Query: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
K V+VTG G G + + + G A ++ DK G + L+ L +C
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSG----ARVVICDKDESGGRALEQ----ELPGAVFILC 61
Query: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGE-VEFTSLETYKQVAEVNLWGTVR 174
+ + V +V +++ + + +VNNAG + E TS + ++Q+ E+NL GT
Sbjct: 62 DVTQEDDVKTLVSETIRRFGR-LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120
Query: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
+TK LP +R+++G V+NISS++G + PY TK V A + L + P GV+V+
Sbjct: 121 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180
Query: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEEL 264
+ PGN +++P +WEEL
Sbjct: 181 CISPGN------IWTP---------LWEEL 195
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 74.3 bits (181), Expect = 1e-13
Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 17/227 (7%)
Query: 31 LLLGSTSFIPIGR---RTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCL 87
LLLG + + I + R ++ +A V +K V++T SG G A+ H+ G A +
Sbjct: 12 LLLGISGLLFIYQEVSRLWSKSA--VQNKVVVITDAISGLGKECARVFHTGG----ARLV 65
Query: 88 MKDKGHDGVKEL-DSLNS----DRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLV 142
+ K + ++ L D+L S + T +L + ++ V ++ + L D + L+
Sbjct: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVL-DCYGCVDILI 124
Query: 143 NNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
NNA + G SLE K++ + N +G + +TK+ LP +I R G++V ++++ G+
Sbjct: 125 NNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFG 184
Query: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLY 248
P R+ Y +K F DCLR E+ V +S V P FI + +Y
Sbjct: 185 IPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSP-TFIRSYHVY 230
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 69.7 bits (169), Expect = 4e-12
Identities = 60/194 (30%), Positives = 89/194 (45%), Gaps = 13/194 (6%)
Query: 59 LVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSE 118
+VTG G G S A+ L G V KDK E+ RT+ ++ S +
Sbjct: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113
Query: 119 EVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSL----ETYKQVAEVNLWGTVR 174
+K+ ++ L E G+ LVNN G+S F + K++ +N+ +
Sbjct: 114 IYDKI----KTGLAGLEIGI--LVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
Query: 175 MTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
MT+ LP ++ R+KG ++NISS G + P + Y TK V+ FS CL E GV V
Sbjct: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFV 227
Query: 234 SVVEPGNFIAATSL 247
V P + AT L
Sbjct: 228 QSVLP--YFVATKL 239
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 69.3 bits (168), Expect = 5e-12
Identities = 61/190 (32%), Positives = 95/190 (50%), Gaps = 15/190 (7%)
Query: 58 VLVTGCDSGFGFSLAKHLHSKGF-LVFAGCLMKDKGHDGVK----ELDSLNSDRLRTVQL 112
V VTG SG G LA L G LV + + + + VK E +L + + L
Sbjct: 53 VWVTGASSGIGEELAYQLSKLGVSLVLSARRVHEL--ERVKRRCLENGNLKEKDILVLPL 110
Query: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGT 172
++ + E + V + LVNN G+S TSL+ Y+++ E+N GT
Sbjct: 111 DLTDTGSHEAATKAVLQEFGRIDI----LVNNGGMSQRSLCMDTSLDVYRKLIELNYLGT 166
Query: 173 VRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEM--YPL 229
V +TK LP +I R +G++V ++S+LG ++ P YC +K + F + LR E+ YP
Sbjct: 167 VSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYP- 225
Query: 230 GVKVSVVEPG 239
G+ VS + PG
Sbjct: 226 GIIVSNICPG 235
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 67.0 bits (162), Expect = 2e-11
Identities = 49/191 (25%), Positives = 93/191 (48%), Gaps = 7/191 (3%)
Query: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
+P+ +K LVT G GF++A+ L G A ++ + V + + +V
Sbjct: 28 DPLANKVALVTASTDGIGFAIARRLAQDG----AHVVVSSRKQQNVDQAVATLQGEGLSV 83
Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTF-GEVEFTSLETYKQVAEVNL 169
VC + E +V +++K G+ LV+NA ++ F G + + E + + ++N+
Sbjct: 84 TGTVCHVGKAEDRERLVATAVK-LHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142
Query: 170 WGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYP 228
MTK+ +P + +R G VV +SS+ +P SPY ++K + + L E+ P
Sbjct: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202
Query: 229 LGVKVSVVEPG 239
++V+ + PG
Sbjct: 203 RNIRVNCLAPG 213
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 66.6 bits (161), Expect = 3e-11
Identities = 46/185 (24%), Positives = 94/185 (50%), Gaps = 7/185 (3%)
Query: 58 VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
V+VTG SG G +A + +G + +DK KE++ + + Q+ +C S
Sbjct: 35 VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHS---INDKQVVLCIS 91
Query: 118 EEVEKVVEIVRSSLKDPEKGMWG---LVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVR 174
+V + V + +K ++ + LVN AG++ G+ E + T++++ +N G+V
Sbjct: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVY 151
Query: 175 MTKSFLPLIR-RAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
+++ + ++ R GR+V +SS G++ + Y +KF + ++ L+ E+ P V +
Sbjct: 152 PSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYI 211
Query: 234 SVVEP 238
+V P
Sbjct: 212 TVAYP 216
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 59.3 bits (142), Expect = 5e-09
Identities = 57/225 (25%), Positives = 96/225 (42%), Gaps = 13/225 (5%)
Query: 31 LLLGSTSFIPIGRRTYASAAEP---VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCL 87
+ LG + F + +A +P V + VL+TG SG G LA G ++ +
Sbjct: 13 IFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDI 72
Query: 88 MKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI 147
K+ + K + R+ + E V +V + V+ + D L+NNAGI
Sbjct: 73 NKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSI----LINNAGI 128
Query: 148 STFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARS 206
T + E ++ +VN + K+FLP +I G +V ISS G +
Sbjct: 129 VTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLA 188
Query: 207 PYCITKFGVEAFSDCLRYEMY---PLGVKVSVVEPGNFIAATSLY 248
YC +KF F++ + E + G+K ++V P F T ++
Sbjct: 189 DYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCP--FFIKTGMF 231
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 58.9 bits (141), Expect = 6e-09
Identities = 65/231 (28%), Positives = 102/231 (44%), Gaps = 38/231 (16%)
Query: 38 FIP-IGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGV 96
FIP +G R A + G AV V+G G G + A+ L S+G +
Sbjct: 52 FIPRLGSR--ADLIKQYGRWAV-VSGATDGIGKAYAEELASRGLNII------------- 95
Query: 97 KELDSLNSDRLRTVQLNVCSSEEVEKVVEI------------VRSSLKDPEKGMWGLVNN 144
L S N ++L+ V ++ + +VE + + +R +LKD + G+ LVNN
Sbjct: 96 --LISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGI--LVNN 151
Query: 145 AGISTFGEVEFTSLETYK--QVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
G+ FT L K + VN+ M LP ++ R KG +V ISS
Sbjct: 152 VGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKP 211
Query: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPES 252
P + + +K ++ FS L+YE G+ V + P F ATS+ +P +
Sbjct: 212 TPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIP--FYVATSMTAPSN 260
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 58.2 bits (139), Expect = 1e-08
Identities = 49/194 (25%), Positives = 90/194 (46%), Gaps = 23/194 (11%)
Query: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRL--- 107
+P+ +K LVT G GF++A+ L +D+ H V N D+
Sbjct: 28 DPLTNKVALVTASTDGIGFAIARRL------------AQDRAHVVVSSRKQQNVDQAVAT 75
Query: 108 -----RTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTF-GEVEFTSLETY 161
+V VC + E +V ++K G+ LV+NA ++ F G + + E +
Sbjct: 76 LQGEGLSVTGTVCHVGKAEDRERLVAMAVK-LHGGIDILVSNAAVNPFFGSLMDVTEEVW 134
Query: 162 KQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSD 220
+ ++N+ MTK+ +P + +R G VV +SS+ +P SPY ++K + ++
Sbjct: 135 DKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNN 194
Query: 221 CLRYEMYPLGVKVS 234
L E+ P ++V+
Sbjct: 195 TLAIELAPRNIRVN 208
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 56.6 bits (135), Expect = 3e-08
Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 4/178 (2%)
Query: 58 VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
VL+TG ++G G LA H G + + V L + ++ + ++ S
Sbjct: 32 VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
Query: 118 EEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTK 177
E E VV+ L + + ++N+ G + G S + + + +VN V++T
Sbjct: 92 EAPESVVQFALDKLGGLD---YLVLNHIGGAPAG-TRARSPQATRWLMQVNFVSYVQLTS 147
Query: 178 SFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSV 235
LP + +KG +V +SS+LGR+ +PY KF ++ F LR E+ V V++
Sbjct: 148 RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 56.6 bits (135), Expect = 3e-08
Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 4/178 (2%)
Query: 58 VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
VL+TG ++G G LA H G + + V L + ++ + ++ S
Sbjct: 32 VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91
Query: 118 EEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTK 177
E E VV+ L + + ++N+ G + G S + + + +VN V++T
Sbjct: 92 EAPESVVQFALDKLGGLD---YLVLNHIGGAPAG-TRARSPQATRWLMQVNFVSYVQLTS 147
Query: 178 SFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSV 235
LP + +KG +V +SS+LGR+ +PY KF ++ F LR E+ V V++
Sbjct: 148 RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 205
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 56.2 bits (134), Expect = 4e-08
Identities = 43/185 (23%), Positives = 79/185 (42%), Gaps = 4/185 (2%)
Query: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
E + K V+VTG G G +A HL G V K+ V L + +
Sbjct: 30 EMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYI 89
Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLW 170
+ E+ V + + + + N ++ F + + ++ EVN
Sbjct: 90 AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHD----DIHHVRKSMEVNFL 145
Query: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
V +T + LP+++++ G +V +SS+ G++A P + Y +KF ++ F +R E
Sbjct: 146 SYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR 205
Query: 231 VKVSV 235
V VS+
Sbjct: 206 VNVSI 210
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 56.2 bits (134), Expect = 4e-08
Identities = 43/185 (23%), Positives = 79/185 (42%), Gaps = 4/185 (2%)
Query: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
E + K V+VTG G G +A HL G V K+ V L + +
Sbjct: 30 EMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYI 89
Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLW 170
+ E+ V + + + + N ++ F + + ++ EVN
Sbjct: 90 AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHD----DIHHVRKSMEVNFL 145
Query: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
V +T + LP+++++ G +V +SS+ G++A P + Y +KF ++ F +R E
Sbjct: 146 SYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR 205
Query: 231 VKVSV 235
V VS+
Sbjct: 206 VNVSI 210
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 55.1 bits (131), Expect = 9e-08
Identities = 56/219 (25%), Positives = 100/219 (45%), Gaps = 14/219 (6%)
Query: 55 SKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDR------LR 108
S LVTG SG G +++ L +G V A L + + V+ L S
Sbjct: 11 SALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHA 70
Query: 109 TVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVN 168
Q +V + ++E V++ P + V+ AGI+ + S + + +V VN
Sbjct: 71 AFQADVSEARAARCLLEQVQACFSRPPSVV---VSCAGITQDEFLLHMSEDDWDKVIAVN 127
Query: 169 LWGTVRMTKSFLPLI--RRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEM 226
L GT +T++ + +G ++NISS++G++ N ++ Y +K GV + E+
Sbjct: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL 187
Query: 227 YPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELP 265
G++ + V PG FIA + + Q + K+ E +P
Sbjct: 188 GRHGIRCNSVLPG-FIATP--MTQKVPQKVVDKITEMIP 223
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,447,079
Number of Sequences: 37866
Number of extensions: 518686
Number of successful extensions: 1440
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 1302
Number of HSP's gapped (non-prelim): 79
length of query: 343
length of database: 18,247,518
effective HSP length: 103
effective length of query: 240
effective length of database: 14,347,320
effective search space: 3443356800
effective search space used: 3443356800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.