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Search of human proteins with 126723191
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126723191 dehydrogenase/reductase (SDR family) member 4 like
2 [Homo sapiens]
(232 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 452 e-127
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 374 e-104
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ... 302 2e-82
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 246 2e-65
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 244 3e-65
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 80 1e-15
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 80 1e-15
gi|40254992 carbonic reductase 4 [Homo sapiens] 75 5e-14
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 74 1e-13
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 73 2e-13
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 73 2e-13
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 71 9e-13
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 70 2e-12
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 69 3e-12
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 69 3e-12
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 69 4e-12
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 69 4e-12
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 67 2e-11
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 66 2e-11
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 65 6e-11
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 65 6e-11
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 63 2e-10
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 63 2e-10
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 62 4e-10
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 62 5e-10
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 61 9e-10
gi|239756089 PREDICTED: similar to hCG1645561 [Homo sapiens] 61 9e-10
gi|239750620 PREDICTED: similar to hCG1645561 [Homo sapiens] 61 9e-10
gi|239744927 PREDICTED: similar to hCG1645561 [Homo sapiens] 61 9e-10
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 60 1e-09
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 452 bits (1162), Expect = e-127
Identities = 232/232 (100%), Positives = 232/232 (100%)
Query: 1 MQMARLLGLCAWARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVV 60
MQMARLLGLCAWARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVV
Sbjct: 1 MQMARLLGLCAWARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVV 60
Query: 61 VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVN 120
VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVN
Sbjct: 61 VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVN 120
Query: 121 PFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS 180
PFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS
Sbjct: 121 PFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS 180
Query: 181 PYNVSKTALLGLNNTLAIELAPRNIRVNCLHLDLSRLASAGCSGWTRKKRKA 232
PYNVSKTALLGLNNTLAIELAPRNIRVNCLHLDLSRLASAGCSGWTRKKRKA
Sbjct: 181 PYNVSKTALLGLNNTLAIELAPRNIRVNCLHLDLSRLASAGCSGWTRKKRKA 232
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 374 bits (961), Expect = e-104
Identities = 197/210 (93%), Positives = 198/210 (94%)
Query: 1 MQMARLLGLCAWARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVV 60
M A LLGLCA A SVRMASS MTRRDPL NKVALVTASTDGIGFAIARRLAQD AHVV
Sbjct: 1 MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV 60
Query: 61 VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVN 120
VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVA AVKLHGGIDILVSNAAVN
Sbjct: 61 VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVN 120
Query: 121 PFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS 180
PFFGS+MDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS
Sbjct: 121 PFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFS 180
Query: 181 PYNVSKTALLGLNNTLAIELAPRNIRVNCL 210
PYNVSKTALLGL TLAIELAPRNIRVNCL
Sbjct: 181 PYNVSKTALLGLTKTLAIELAPRNIRVNCL 210
>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
[Homo sapiens]
Length = 281
Score = 302 bits (773), Expect = 2e-82
Identities = 162/213 (76%), Positives = 178/213 (83%), Gaps = 3/213 (1%)
Query: 1 MQMARLLGLCAWARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVV 60
M ARL G CA A KSVR+ASS MTRRDPLTNKVALVTASTD IGFA+A+RLAQD AHVV
Sbjct: 1 MHKARLRGHCARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVV 60
Query: 61 VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDIL---VSNA 117
VS RKQQNVDQAVATLQGEGLS+TGTVCHVGK +D ERLVA A+KLHG IDIL ++N+
Sbjct: 61 VSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNS 120
Query: 118 AVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSP 177
F+ +L+ EE WD+ LDIN KA ALM KAVVPEMEKRGGGSV ++S+AAF P P
Sbjct: 121 KRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLP 180
Query: 178 GFSPYNVSKTALLGLNNTLAIELAPRNIRVNCL 210
GFSPYNVSKTALLGLN TLAIELAPRNIRVNCL
Sbjct: 181 GFSPYNVSKTALLGLNKTLAIELAPRNIRVNCL 213
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 246 bits (627), Expect = 2e-65
Identities = 130/223 (58%), Positives = 166/223 (74%), Gaps = 6/223 (2%)
Query: 13 ARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQA 72
AR SVRM+S+ + R+ L N+VA+VT ST GIGFAIARRLA+D AHVV+SSRKQQNVD+A
Sbjct: 17 ARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRA 76
Query: 73 VATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEE 132
+A LQGEGLSV G VCHVGKAEDRE+LVA A++ GG+D LV +A VNP GS + +E+
Sbjct: 77 MAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQ 136
Query: 133 VWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGL 192
+WDK L +NVK+PAL+ ++P ME R G+V++VSSIAA++P YNVSKTALLGL
Sbjct: 137 IWDKILSVNVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTALLGL 195
Query: 193 NNTLAIELAPRNIRVNC-----LHLDLSRLASAGCSGWTRKKR 230
TLA+ELAP++IRVNC + D S++ G G + R
Sbjct: 196 TRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGR 238
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 244 bits (624), Expect = 3e-65
Identities = 130/222 (58%), Positives = 165/222 (74%), Gaps = 6/222 (2%)
Query: 13 ARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQA 72
AR SVRM+S+ + R+ L N+VA+VT ST GIGFAIARRLA+D AHVV+SSRKQQNVD+A
Sbjct: 17 ARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRA 76
Query: 73 VATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEE 132
+A LQGEGLSV G VCHVGKAEDRE+LVA A++ GG+D LV +A VNP GS + +E+
Sbjct: 77 MAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQ 136
Query: 133 VWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGL 192
+WDK L +NVK+PAL+ ++P ME R G+V++VSSIAA++P YNVSKTALLGL
Sbjct: 137 IWDKILSVNVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTALLGL 195
Query: 193 NNTLAIELAPRNIRVNC-----LHLDLSRLASAGCSGWTRKK 229
TLA+ELAP++IRVNC + D S++ S W K
Sbjct: 196 TRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFK 237
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 80.1 bits (196), Expect = 1e-15
Identities = 59/186 (31%), Positives = 98/186 (52%), Gaps = 7/186 (3%)
Query: 26 RRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85
R + L K +VT ++ GIG +A LA+ AHVVV++R ++ + + V+ G +
Sbjct: 28 RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87
Query: 86 TVCHVGKAED---RERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINV 142
+ G ED E+ VA A KL GG+D+L+ N N D V K++++N
Sbjct: 88 YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144
Query: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP 202
+ ++T A +P M K+ GS+V+VSS+A P + Y+ SK AL G +++ E +
Sbjct: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 203 RNIRVN 208
+ V+
Sbjct: 204 SRVNVS 209
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 80.1 bits (196), Expect = 1e-15
Identities = 59/186 (31%), Positives = 98/186 (52%), Gaps = 7/186 (3%)
Query: 26 RRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85
R + L K +VT ++ GIG +A LA+ AHVVV++R ++ + + V+ G +
Sbjct: 28 RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87
Query: 86 TVCHVGKAED---RERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINV 142
+ G ED E+ VA A KL GG+D+L+ N N D V K++++N
Sbjct: 88 YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144
Query: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP 202
+ ++T A +P M K+ GS+V+VSS+A P + Y+ SK AL G +++ E +
Sbjct: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 203 RNIRVN 208
+ V+
Sbjct: 204 SRVNVS 209
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 75.1 bits (183), Expect = 5e-14
Identities = 58/190 (30%), Positives = 91/190 (47%), Gaps = 9/190 (4%)
Query: 32 NKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVG 91
+KV V + GIG A+A+ +A+ + V +R + A L G+ L+ + C V
Sbjct: 2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58
Query: 92 KAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKA 151
K D + K G ++ LV+ A +N G L+ E L N+ L KA
Sbjct: 59 KEHDVQNTFEELEKHLGRVNFLVNAAGINRD-GLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
Query: 152 VVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNC-- 209
+ M ++ GGS+V V SI + G S Y+ SK L+G + LA E+A + IRVN
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
Query: 210 ---LHLDLSR 216
+H D+++
Sbjct: 178 PGFVHTDMTK 187
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 73.6 bits (179), Expect = 1e-13
Identities = 56/188 (29%), Positives = 87/188 (46%), Gaps = 11/188 (5%)
Query: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQG-----EGLSVT 84
L +VA+VT GIG AI + L + ++VV++SRK + + A LQ + V
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 85 GTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKA 144
C++ E+ LV + G I+ LV+N F ++ + W L+ N+
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-GQFLSPAEHISSKGWHAVLETNLTG 134
Query: 145 PALMTKAVVPEMEKRGGGSVV--IVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP 202
M KAV K GGS+V IV + A F P ++ + L +LA+E A
Sbjct: 135 TFYMCKAVYSSWMKEHGGSIVNIIVPTKAGF---PLAVHSGAARAGVYNLTKSLALEWAC 191
Query: 203 RNIRVNCL 210
IR+NC+
Sbjct: 192 SGIRINCV 199
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 73.2 bits (178), Expect = 2e-13
Identities = 55/188 (29%), Positives = 84/188 (44%), Gaps = 4/188 (2%)
Query: 26 RRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85
RR +T ++ L+T + GIG A A+ ++ +V+ + +++ A +G G V
Sbjct: 30 RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHT 89
Query: 86 TVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAP 145
V ED G + ILV+NA V + L + +KT ++NV A
Sbjct: 90 FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGV-VYTSDLFATQDPQIEKTFEVNVLAH 148
Query: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP--- 202
TKA +P M K G +V V+S A P Y SK A +G + TL ELA
Sbjct: 149 FWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQI 208
Query: 203 RNIRVNCL 210
++ CL
Sbjct: 209 TGVKTTCL 216
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 72.8 bits (177), Expect = 2e-13
Identities = 60/198 (30%), Positives = 97/198 (48%), Gaps = 11/198 (5%)
Query: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 89
L + LVT + GIG + L A VV SR Q ++D V G +
Sbjct: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60
Query: 90 VGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMT 149
+G E ER + G +D+LV+NAAV ++VT+E +D++ ++N++A ++
Sbjct: 61 LGDWEATERALGSV----GPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115
Query: 150 KAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVN 208
+ V + RG G++V VSS + S Y +K AL L +A+EL P IRVN
Sbjct: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175
Query: 209 CLHLDLSRLASAGCSGWT 226
++ + + S G + W+
Sbjct: 176 AVNPTVV-MTSMGQATWS 192
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 70.9 bits (172), Expect = 9e-13
Identities = 49/188 (26%), Positives = 88/188 (46%), Gaps = 4/188 (2%)
Query: 26 RRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85
RR + ++ L+T + GIG A+ ++ +V+ ++ V++ A + G++
Sbjct: 30 RRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHA 89
Query: 86 TVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAP 145
V E+ R + K G + I+V+NA + L+ +E KT ++N+
Sbjct: 90 YVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGT-VYPADLLSTKDEEITKTFEVNILGH 148
Query: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIE---LAP 202
+TKA++P M +R G +V V+S+ P PY SK A +G + L E L
Sbjct: 149 FWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 208
Query: 203 RNIRVNCL 210
I+ +CL
Sbjct: 209 TGIKTSCL 216
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 69.7 bits (169), Expect = 2e-12
Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 4/178 (2%)
Query: 33 KVALVTASTDGIGFAIARRLAQD--RAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHV 90
+ L++ + GIG +A +LA D + + VV++ + + + GE L T TV +
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQL 65
Query: 91 GKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTK 150
D E + + G +D+LV+NA + G L ++ D N + K
Sbjct: 66 DVCSD-ESVAQCLSCIQGEVDVLVNNAGMG-LVGPLEGLSLAAMQNVFDTNFFGAVRLVK 123
Query: 151 AVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVN 208
AV+P M++R G +V++SS+ Y SK AL G +LAI+L NI ++
Sbjct: 124 AVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 69.3 bits (168), Expect = 3e-12
Identities = 46/178 (25%), Positives = 83/178 (46%), Gaps = 5/178 (2%)
Query: 33 KVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGK 92
KV +VT GIG I R A VV+ + + L G +C V +
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPG----AVFILCDVTQ 65
Query: 93 AEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKAV 152
+D + LV+ ++ G +D +V+NA +P + + + + + L++N+ +TK
Sbjct: 66 EDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125
Query: 153 VPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNCL 210
+P + K G + I S + A + PY +K A+ + LA++ +P +RVNC+
Sbjct: 126 LPYLRKSQGNVINISSLVGAIGQAQAV-PYVATKGAVTAMTKALALDESPYGVRVNCI 182
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 69.3 bits (168), Expect = 3e-12
Identities = 55/196 (28%), Positives = 89/196 (45%), Gaps = 25/196 (12%)
Query: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 89
L N V ++T +T G+G A+ A +V+ R +++ + L T H
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIREL---------TASH 100
Query: 90 VGKAE------------DRERLVAMAVKL---HGGIDILVSNAAVNPFFGSLMDVTEEVW 134
K + D +VA A ++ G +DILV+NA ++ + G++MD T +V
Sbjct: 101 ATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGIS-YRGTIMDTTVDVD 159
Query: 135 DKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNN 194
+ ++ N P +TKA++P M KR G +V +SSI P S Y SK A +
Sbjct: 160 KRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFD 219
Query: 195 TLAIELAPRNIRVNCL 210
L E+ I V +
Sbjct: 220 CLRAEMEQYEIEVTVI 235
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 68.6 bits (166), Expect = 4e-12
Identities = 53/187 (28%), Positives = 92/187 (49%), Gaps = 13/187 (6%)
Query: 33 KVALVTASTDGIGFAIARRLAQDRAHVVVSS---------RKQQNVDQAVATLQGEGLSV 83
+V LVT + G+G A A A+ A VVV+ + D+ V ++ G
Sbjct: 10 RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA 69
Query: 84 TGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVK 143
V + E+ E++V A+ G ID++V+NA + S +++E WD ++++
Sbjct: 70 ---VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRD-RSFARISDEDWDIIHRVHLR 125
Query: 144 APALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPR 203
+T+A M+K+ G +++ SS + + G + Y+ +K LLGL N+LAIE
Sbjct: 126 GSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKS 185
Query: 204 NIRVNCL 210
NI N +
Sbjct: 186 NIHCNTI 192
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 68.6 bits (166), Expect = 4e-12
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 15/184 (8%)
Query: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQA--VATLQGEGLSVTGTV 87
L KV ++TA+ GIG A A A++ A V+ + + + + +Q L VT
Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKK 63
Query: 88 CHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPAL 147
A + ERL D+L N A G+++D E+ WD ++++NV++ L
Sbjct: 64 QIDQFANEVERL-----------DVLF-NVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYL 111
Query: 148 MTKAVVPEMEKRGGGSVVIVSSIA-AFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIR 206
M KA +P+M + G+++ +SS+A + Y+ +K A++GL ++A + + IR
Sbjct: 112 MIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIR 171
Query: 207 VNCL 210
NC+
Sbjct: 172 CNCV 175
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 66.6 bits (161), Expect = 2e-11
Identities = 53/192 (27%), Positives = 87/192 (45%), Gaps = 19/192 (9%)
Query: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGL---SVTGT 86
+ V L+T + GIG +A RLA D + + V + L+ +G +
Sbjct: 1 MARTVVLITGCSSGIGLHLAVRLASDPS-------QSFKVYATLRDLKTQGRLWEAARAL 53
Query: 87 VCHVGKAE-------DRERLVAMAVKL-HGGIDILVSNAAVNPFFGSLMDVTEEVWDKTL 138
C G E D + + A ++ G +D+LV NA + G L + E+ L
Sbjct: 54 ACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVL 112
Query: 139 DINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAI 198
D+NV M +A +P+M++RG G V++ S+ P Y SK AL GL +LA+
Sbjct: 113 DVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAV 172
Query: 199 ELAPRNIRVNCL 210
L P + ++ +
Sbjct: 173 LLLPFGVHLSLI 184
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 66.2 bits (160), Expect = 2e-11
Identities = 52/181 (28%), Positives = 91/181 (50%), Gaps = 9/181 (4%)
Query: 35 ALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAE 94
A+V+ +TDGIG A A LA ++++ SR ++ + Q VA + V + +
Sbjct: 70 AVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADFSS 128
Query: 95 DRERLVAMAVKLHG-GIDILVSNAAV----NPFFGSLMDVTEEVWDKTLDINVKAPALMT 149
RE + + L + ILV+N V +F L + +++WD +++N+ A +LM
Sbjct: 129 GREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSE--DKLWD-IINVNIAAASLMV 185
Query: 150 KAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRVNC 209
V+P M +R G++V +SS + P+P + ++ SK L + L E A + I V
Sbjct: 186 HVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQS 245
Query: 210 L 210
L
Sbjct: 246 L 246
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 64.7 bits (156), Expect = 6e-11
Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 2/172 (1%)
Query: 30 LTNKVALVTASTDGIGFAIARRLAQDRAH-VVVSSRKQQNVDQAVATLQGEGLSVTGTVC 88
L+ + L+T GIG +AR A+ A +V+ R ++ + + ++ G +C
Sbjct: 36 LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFIC 95
Query: 89 HVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALM 148
VG E+ + + G I ILV+NAAV SLMD ++ K+ IN
Sbjct: 96 DVGNREEVYQTAKAVREKVGDITILVNNAAV-VHGKSLMDSDDDALLKSQHINTLGQFWT 154
Query: 149 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIEL 200
TKA +P M + G +V ++S+ A S PG Y SK + +L + L
Sbjct: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGL 206
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 64.7 bits (156), Expect = 6e-11
Identities = 54/183 (29%), Positives = 85/183 (46%), Gaps = 19/183 (10%)
Query: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEG--------- 80
LT+ V VT ++ GIG +A +L++ +V+S+R+ +++ G
Sbjct: 48 LTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILV 107
Query: 81 --LSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTL 138
L +T T H E ++ G IDILV+N ++ MD + +V+ K +
Sbjct: 108 LPLDLTDTGSH-------EAATKAVLQEFGRIDILVNNGGMSQR-SLCMDTSLDVYRKLI 159
Query: 139 DINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAI 198
++N +TK V+P M +R G +V V+SI P Y SK AL G N L
Sbjct: 160 ELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRT 219
Query: 199 ELA 201
ELA
Sbjct: 220 ELA 222
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 63.2 bits (152), Expect = 2e-10
Identities = 52/190 (27%), Positives = 92/190 (48%), Gaps = 15/190 (7%)
Query: 32 NKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTV---- 87
+++ALVT ++ GIG A+AR L Q VV +R N+++ A + G GT+
Sbjct: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAG--YPGTLIPYR 68
Query: 88 CHVGKAEDRERLVAMAVKLHGGIDILVSNAAV-NPFFGSLMDVTEEVWDKTLDINVKAPA 146
C + ED + + H G+DI ++NA + P +L+ + W ++NV A +
Sbjct: 69 CDLSNEEDILSMFSAIRSQHSGVDICINNAGLARP--DTLLSGSTSGWKDMFNVNVLALS 126
Query: 147 LMTKAVVPEMEKRG--GGSVVIVSSIAAFS--PSPGFSPYNVSKTALLGLNNTLAIEL-- 200
+ T+ M++R G ++ ++S++ P Y+ +K A+ L L EL
Sbjct: 127 ICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE 186
Query: 201 APRNIRVNCL 210
A +IR C+
Sbjct: 187 AQTHIRATCI 196
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 62.8 bits (151), Expect = 2e-10
Identities = 56/198 (28%), Positives = 85/198 (42%), Gaps = 11/198 (5%)
Query: 19 MASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQG 78
MAS R L + +ALVT + GIG A++ RLA + A V + + V L G
Sbjct: 1 MASQLQNR---LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGG 57
Query: 79 EGLSV-------TGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTE 131
G V +A L+ +V + A L+ ++E
Sbjct: 58 PGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSE 117
Query: 132 EVWDKTLDINVKAPALMTKAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALL 190
+ WDK + +N+K L+T+A + G GS++ +SSI + G + Y SK ++
Sbjct: 118 DDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVI 177
Query: 191 GLNNTLAIELAPRNIRVN 208
GL T A EL IR N
Sbjct: 178 GLTQTAARELGRHGIRCN 195
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 62.0 bits (149), Expect = 4e-10
Identities = 48/177 (27%), Positives = 85/177 (48%), Gaps = 6/177 (3%)
Query: 36 LVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVC--HVGKA 93
+VT + GIG IA + A + + +R + + QA ++ ++ V V +
Sbjct: 36 VVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVS 95
Query: 94 EDR---ERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALMTK 150
+D E ++ A + G +D+LV N A G D+ +++ + IN ++
Sbjct: 96 QDYNQVENVIKQAQEKLGPVDMLV-NCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSR 154
Query: 151 AVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIRV 207
AV+ M++R G +V VSS A GF+ Y+ SK A+ GL L +E+ P N+ +
Sbjct: 155 AVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYI 211
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 61.6 bits (148), Expect = 5e-10
Identities = 48/158 (30%), Positives = 85/158 (53%), Gaps = 8/158 (5%)
Query: 35 ALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAE 94
A+VT STDGIG + A LA+ VV+ SR + +DQ + ++ + T T+ +E
Sbjct: 53 AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASE 112
Query: 95 D-RERLVAMAVKLHGGIDILVSNAAVN----PFFGSLMDVTEEVWDKTLDINVKAPALMT 149
D +++ L I ILV+N ++ +F + D+ + V K ++IN+ + MT
Sbjct: 113 DIYDKIKTGLAGLE--IGILVNNVGMSYEYPEYFLDVPDL-DNVIKKMININILSVCKMT 169
Query: 150 KAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKT 187
+ V+P M +R G+++ +SS + P P + Y+ +KT
Sbjct: 170 QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKT 207
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 60.8 bits (146), Expect = 9e-10
Identities = 56/188 (29%), Positives = 79/188 (42%), Gaps = 16/188 (8%)
Query: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATL--QGEGLSVTGTV 87
+ KVALVT + GIG A A L A V + + Q A L Q E
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
Query: 88 CHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPAL 147
C V + V G +DILV+NA VN E+ W+KTL IN+ +
Sbjct: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVIS 113
Query: 148 MTKAVVPEMEKRGGGS---VVIVSSIAAFSPSPGFSPYNVSKTALLGLNNT--LAIELAP 202
T + M K+ GG ++ +SS+A P Y SK ++G + LA L
Sbjct: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMN 173
Query: 203 RNIRVNCL 210
+R+N +
Sbjct: 174 SGVRLNAI 181
>gi|239756089 PREDICTED: similar to hCG1645561 [Homo sapiens]
Length = 41
Score = 60.8 bits (146), Expect = 9e-10
Identities = 30/41 (73%), Positives = 35/41 (85%)
Query: 36 LVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATL 76
++T ST+ GFAIA+RLA DRAHVV+SS KQQNVD AVATL
Sbjct: 1 MITGSTNRFGFAIAQRLAHDRAHVVISSGKQQNVDWAVATL 41
>gi|239750620 PREDICTED: similar to hCG1645561 [Homo sapiens]
Length = 41
Score = 60.8 bits (146), Expect = 9e-10
Identities = 30/41 (73%), Positives = 35/41 (85%)
Query: 36 LVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATL 76
++T ST+ GFAIA+RLA DRAHVV+SS KQQNVD AVATL
Sbjct: 1 MITGSTNRFGFAIAQRLAHDRAHVVISSGKQQNVDWAVATL 41
>gi|239744927 PREDICTED: similar to hCG1645561 [Homo sapiens]
Length = 41
Score = 60.8 bits (146), Expect = 9e-10
Identities = 30/41 (73%), Positives = 35/41 (85%)
Query: 36 LVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATL 76
++T ST+ GFAIA+RLA DRAHVV+SS KQQNVD AVATL
Sbjct: 1 MITGSTNRFGFAIAQRLAHDRAHVVISSGKQQNVDWAVATL 41
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 60.5 bits (145), Expect = 1e-09
Identities = 44/174 (25%), Positives = 78/174 (44%), Gaps = 2/174 (1%)
Query: 27 RDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVV-SSRKQQNVDQAVATLQGEGLSVTG 85
R + ++ L+T + G+G +A + A+ + +V+ K+ N + + V
Sbjct: 35 RKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHA 94
Query: 86 TVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAP 145
C + E R+ K G + IL++NA + +D +E+ +K+ D+N KA
Sbjct: 95 YTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTG-KKFLDCPDELMEKSFDVNFKAH 153
Query: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIE 199
KA +P M G +V +SS A S G + Y SK A G ++ +E
Sbjct: 154 LWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVE 207
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.131 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,468,397
Number of Sequences: 37866
Number of extensions: 285783
Number of successful extensions: 741
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 622
Number of HSP's gapped (non-prelim): 78
length of query: 232
length of database: 18,247,518
effective HSP length: 99
effective length of query: 133
effective length of database: 14,498,784
effective search space: 1928338272
effective search space used: 1928338272
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.