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Search of human proteins with 42475970
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
sapiens]
(735 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap... 1509 0.0
gi|149274655 synapse defective 1, Rho GTPase, homolog 2 [Homo sa... 443 e-124
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 121 3e-27
gi|229094128 active breakpoint cluster region-related protein i... 119 1e-26
gi|38679957 active breakpoint cluster region-related protein is... 119 1e-26
gi|38679954 active breakpoint cluster region-related protein is... 119 1e-26
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 117 3e-26
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] 103 4e-22
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 103 4e-22
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 103 4e-22
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 102 1e-21
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 101 2e-21
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 101 2e-21
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 101 2e-21
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 101 2e-21
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 99 1e-20
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 99 1e-20
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 99 1e-20
gi|91208437 GEM interacting protein [Homo sapiens] 99 1e-20
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 96 2e-19
gi|188497642 ARHGAP15 [Homo sapiens] 95 2e-19
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 92 2e-18
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 92 2e-18
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 89 1e-17
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 89 2e-17
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 89 2e-17
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 87 4e-17
gi|156119615 myosin IXA [Homo sapiens] 87 4e-17
gi|239757488 PREDICTED: chromosome 20 open reading frame 95 [Hom... 87 6e-17
gi|239752003 PREDICTED: chromosome 20 open reading frame 95 [Hom... 87 6e-17
>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
sapiens]
Length = 735
Score = 1509 bits (3906), Expect = 0.0
Identities = 735/735 (100%), Positives = 735/735 (100%)
Query: 1 MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSS 60
MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSS
Sbjct: 1 MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSS 60
Query: 61 PEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDP 120
PEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDP
Sbjct: 61 PEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDP 120
Query: 121 RPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRL 180
RPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRL
Sbjct: 121 RPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRL 180
Query: 181 SLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPA 240
SLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPA
Sbjct: 181 SLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPA 240
Query: 241 GPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEAR 300
GPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEAR
Sbjct: 241 GPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEAR 300
Query: 301 ARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGC 360
ARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGC
Sbjct: 301 ARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGC 360
Query: 361 QAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKC 420
QAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKC
Sbjct: 361 QAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKC 420
Query: 421 VGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLR 480
VGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLR
Sbjct: 421 VGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLR 480
Query: 481 ELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVS 540
ELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVS
Sbjct: 481 ELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVS 540
Query: 541 SFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW 600
SFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW
Sbjct: 541 SFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW 600
Query: 601 PDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGR 660
PDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGR
Sbjct: 601 PDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGR 660
Query: 661 DFLPCGRDFLSGPDYDHVTGSDSEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALI 720
DFLPCGRDFLSGPDYDHVTGSDSEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALI
Sbjct: 661 DFLPCGRDFLSGPDYDHVTGSDSEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALI 720
Query: 721 LDLERELSKQINVCL 735
LDLERELSKQINVCL
Sbjct: 721 LDLERELSKQINVCL 735
>gi|149274655 synapse defective 1, Rho GTPase, homolog 2 [Homo
sapiens]
Length = 1194
Score = 443 bits (1139), Expect = e-124
Identities = 297/703 (42%), Positives = 388/703 (55%), Gaps = 111/703 (15%)
Query: 126 EPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRLSLRG- 184
EP P P S +G + + P + KSP R+LS+KMKKLPE R+LS++G
Sbjct: 497 EPSSPNP-SPVKKGSSINWSLP-------DKIKSPRTVRKLSMKMKKLPEFSRKLSVKGT 548
Query: 185 ----------PRAGRERERAA------PAGS--------VISRYHLDSSVGGPGPAAGPG 220
P + R P+G+ VISRYHLD+SV
Sbjct: 549 LNYINSPDNTPSLSKYNCREVHHTDILPSGNTTTAAKRNVISRYHLDTSVSSQQSYQKKN 608
Query: 221 GTRSP---RAGYLSDGDSPERPAGPPSPTS------------------------FRPYEV 253
S + GYLSDGDSPE S FR Y
Sbjct: 609 SMSSKYSCKGGYLSDGDSPELTTKASKHGSENKFGKGKEIISNSCSKNEIDIDAFRHYSF 668
Query: 254 GPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEARARTGPLRGGPDFL 313
+ + G +S+H YG L+P P +D+ C +QVD +ART L FL
Sbjct: 669 SDQPKCSQY-ISGLMSVHFYGAEDLKP-PRIDSKDVFCAIQVDSVNKARTALLTCRTTFL 726
Query: 314 RLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQG 373
+DHTF++E+E A+ L+ +V +W+P R++R C GTV+LPT+FR + QLAV+LEP+G
Sbjct: 727 DMDHTFNIEIENAQHLKLVVFSWEPTPRKNRVCCHGTVVLPTLFRVTKTHQLAVKLEPRG 786
Query: 374 LLYAKLTLSEQQE-----APATAEPRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRG 428
L+Y K+TL EQ E EP +FG+ + +VE+E VPL+IQKC+ +IE+RG
Sbjct: 787 LIYVKVTLMEQWENSLHGLDINQEPIIFGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRG 846
Query: 429 LRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLIT 488
+VVGLYRLCGSAAVKKELR+AFERDS AV L E+ YPDINVITG+LKDYLRELP+PLIT
Sbjct: 847 CQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVLKDYLRELPSPLIT 906
Query: 489 QPLYKVVLEAMARDP-------PNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSS 541
+ LY+ VL+AMA+ P P ++ T LL CLP++E+ATL +LLDHL+LV+S
Sbjct: 907 KQLYEAVLDAMAKSPLKMSSNGCENDPGDSKYTVDLLDCLPEIEKATLKMLLDHLKLVAS 966
Query: 542 FHAYNRMTPQNLAVCFGPVLLPARQAPT--RPRARSSGPGLASAVDFKHHIEVLHYLLQS 599
+H N+MT QNLAVCFGPVLL RQ P+ R + LASA+DFK HIEVLHYLLQ
Sbjct: 967 YHEVNKMTCQNLAVCFGPVLLSQRQEPSTHNNRVFTDSEELASALDFKKHIEVLHYLLQL 1026
Query: 600 WPDPRL----------PRQSPDVAPYLRPKRQPP--LHLPLADPEVVTRPRGRGGPESPP 647
WP RL P Q + YLR K++ P L+L D V RPR + +SP
Sbjct: 1027 WPVQRLTVKKSTDNLFPEQKSSL-NYLRQKKERPHMLNLSGTDSSGVLRPR-QNRLDSPL 1084
Query: 648 SNRYAGDWSVCGRDFLPCGRDFLSGPDYDHVTGSDSE--------DEDEEVGEPRVTGDF 699
SNRYAGDWS CG ++ ++ L+ DYD V D + D E + E +
Sbjct: 1085 SNRYAGDWSSCGENYFLNTKENLNDVDYDDVPSEDRKIGENYSKMDGPEVMIEQPIPMSK 1144
Query: 700 EDDF---------DAPFNPHLNLKD----FDALILDLERELSK 729
E F ++ + NLKD D LI +LEREL+K
Sbjct: 1145 ECTFQTYLTMQTVESTVDRKNNLKDLQESIDTLIGNLERELNK 1187
Score = 31.6 bits (70), Expect = 2.8
Identities = 11/12 (91%), Positives = 12/12 (100%)
Query: 108 GEIWYNPIPEED 119
GEIWYNPIPE+D
Sbjct: 368 GEIWYNPIPEDD 379
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 121 bits (303), Expect = 3e-27
Identities = 111/372 (29%), Positives = 176/372 (47%), Gaps = 42/372 (11%)
Query: 264 LWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDG------EARARTGPLRGGPDFLRLDH 317
L+G L++ ++ G + + +L C L+VD +A+ R P++ +
Sbjct: 909 LYGFLNVIVHSATGFKQSS-----NLYCTLEVDSFGYFVNKAKTRVYRDTAEPNW---NE 960
Query: 318 TFHLELEAARLLRALV---------LAWDPGVRRHRPCAQGTVLL-PTVFRGCQAQQLAV 367
F +ELE ++ LR L + + G R +G V L P + Q+ +
Sbjct: 961 EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVI 1020
Query: 368 RLEP-QGLLYAKLTLSE--QQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKCVGQI 424
+ + L K E + P+ + VFG+ + ++ +RER +VP I+++CV +I
Sbjct: 1021 AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRER--SKVPYIVRQCVEEI 1078
Query: 425 ERRGLRVVGLYRLCGSAAVKKELRDAFERDS--AAVCLSEDLYPDINVITGILKDYLREL 482
ERRG+ VG+YR+ G A + L+ AF+ ++ +V +SE D+N I G LK Y REL
Sbjct: 1079 ERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSE---MDVNAIAGTLKLYFREL 1135
Query: 483 PTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSF 542
P PL T Y E +A P LL LP+ T LLDHL+ V+
Sbjct: 1136 PEPLFTDEFYPNFAEGIALSDP---VAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEK 1192
Query: 543 HAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLAS---AVDFKHHIEVLHYLLQ- 598
A N+M+ NLA FGP LL + ++ A S P + +++ ++VL Y LQ
Sbjct: 1193 EAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQL 1252
Query: 599 -SWPDPRLPRQS 609
+ P P RQS
Sbjct: 1253 EAIPAPDSKRQS 1264
Score = 31.2 bits (69), Expect = 3.6
Identities = 37/159 (23%), Positives = 53/159 (33%), Gaps = 21/159 (13%)
Query: 33 AQRPEPSPPEPEPQAPEGSQAGAEGPSSP------EASRSPARGAYLQSLEPSSR----- 81
AQ P+ PP E ++ + E + E ++ R YLQ+L +
Sbjct: 13 AQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDR 72
Query: 82 -RWVLGGAKPAEDTSLGPGVPGTGEP-AGEIWYNPIPEEDPRPPAPEPPGPQPGSAESEG 139
RW A A D G EP A P P + PP E P +P S G
Sbjct: 73 QRWGFRRAAQAPD--------GASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPG 124
Query: 140 LAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRR 178
A G A + GP ++ +R+
Sbjct: 125 KARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRK 163
Score = 31.2 bits (69), Expect = 3.6
Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 11/74 (14%)
Query: 7 RKTFSRLR-GREKLPRKKSDAKERGHPAQRPEPSP-------PEPEPQA-PEGSQAGAEG 57
+K++ R R G + + A E A RP+P+P P EP+A P+G G+ G
Sbjct: 67 KKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE--GSPG 124
Query: 58 PSSPEASRSPARGA 71
+ P +R P A
Sbjct: 125 KARPGTARRPGAAA 138
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 119 bits (297), Expect = 1e-26
Identities = 107/368 (29%), Positives = 169/368 (45%), Gaps = 57/368 (15%)
Query: 264 LWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDG----EARARTGPLRGGPDFLRLDHTF 319
L+G L + ++ G + + +L C L+VD ++A+T R + + D F
Sbjct: 456 LYGFLHVIVHSAKGFKQSA-----NLYCTLEVDSFGYFVSKAKTRVFRDTAE-PKWDEEF 509
Query: 320 HLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGL----- 374
+ELE ++ LR +L ++ + + ++ + Q Q L+PQ +
Sbjct: 510 EIELEGSQSLR--ILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQ-----LDPQTVETKNW 562
Query: 375 -------------LYAKLTLSEQ--QEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQK 419
K T + + P+ + VFG+ + ++ +RER +VP I+++
Sbjct: 563 HTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRER--SKVPYIVRQ 620
Query: 420 CVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLS-EDLYPDINVITGILKDY 478
CV ++E+RG+ VG+YR+ G A + L+ F+ ++ + L D+ DIN I G LK Y
Sbjct: 621 CVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDM--DINAIAGTLKLY 678
Query: 479 LRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRL 538
RELP PL+T LY +E +A P LL LPD T LL+HL+
Sbjct: 679 FRELPEPLLTDRLYPAFMEGIALSDP---AAKENCMMHLLRSLPDPNLITFLFLLEHLKR 735
Query: 539 VSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHH-----IEVL 593
V+ N+M+ NLA FGP LL RP S L SA D H ++VL
Sbjct: 736 VAEKEPINKMSLHNLATVFGPTLL-------RPSEVESKAHLTSAADIWSHDVMAQVQVL 788
Query: 594 HYLLQSWP 601
Y LQ P
Sbjct: 789 LYYLQHPP 796
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 119 bits (297), Expect = 1e-26
Identities = 107/368 (29%), Positives = 169/368 (45%), Gaps = 57/368 (15%)
Query: 264 LWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDG----EARARTGPLRGGPDFLRLDHTF 319
L+G L + ++ G + + +L C L+VD ++A+T R + + D F
Sbjct: 502 LYGFLHVIVHSAKGFKQSA-----NLYCTLEVDSFGYFVSKAKTRVFRDTAE-PKWDEEF 555
Query: 320 HLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGL----- 374
+ELE ++ LR +L ++ + + ++ + Q Q L+PQ +
Sbjct: 556 EIELEGSQSLR--ILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQ-----LDPQTVETKNW 608
Query: 375 -------------LYAKLTLSEQ--QEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQK 419
K T + + P+ + VFG+ + ++ +RER +VP I+++
Sbjct: 609 HTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRER--SKVPYIVRQ 666
Query: 420 CVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLS-EDLYPDINVITGILKDY 478
CV ++E+RG+ VG+YR+ G A + L+ F+ ++ + L D+ DIN I G LK Y
Sbjct: 667 CVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDM--DINAIAGTLKLY 724
Query: 479 LRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRL 538
RELP PL+T LY +E +A P LL LPD T LL+HL+
Sbjct: 725 FRELPEPLLTDRLYPAFMEGIALSDP---AAKENCMMHLLRSLPDPNLITFLFLLEHLKR 781
Query: 539 VSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHH-----IEVL 593
V+ N+M+ NLA FGP LL RP S L SA D H ++VL
Sbjct: 782 VAEKEPINKMSLHNLATVFGPTLL-------RPSEVESKAHLTSAADIWSHDVMAQVQVL 834
Query: 594 HYLLQSWP 601
Y LQ P
Sbjct: 835 LYYLQHPP 842
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 119 bits (297), Expect = 1e-26
Identities = 107/368 (29%), Positives = 169/368 (45%), Gaps = 57/368 (15%)
Query: 264 LWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDG----EARARTGPLRGGPDFLRLDHTF 319
L+G L + ++ G + + +L C L+VD ++A+T R + + D F
Sbjct: 465 LYGFLHVIVHSAKGFKQSA-----NLYCTLEVDSFGYFVSKAKTRVFRDTAE-PKWDEEF 518
Query: 320 HLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGL----- 374
+ELE ++ LR +L ++ + + ++ + Q Q L+PQ +
Sbjct: 519 EIELEGSQSLR--ILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQ-----LDPQTVETKNW 571
Query: 375 -------------LYAKLTLSEQ--QEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQK 419
K T + + P+ + VFG+ + ++ +RER +VP I+++
Sbjct: 572 HTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRER--SKVPYIVRQ 629
Query: 420 CVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLS-EDLYPDINVITGILKDY 478
CV ++E+RG+ VG+YR+ G A + L+ F+ ++ + L D+ DIN I G LK Y
Sbjct: 630 CVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDM--DINAIAGTLKLY 687
Query: 479 LRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRL 538
RELP PL+T LY +E +A P LL LPD T LL+HL+
Sbjct: 688 FRELPEPLLTDRLYPAFMEGIALSDP---AAKENCMMHLLRSLPDPNLITFLFLLEHLKR 744
Query: 539 VSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHH-----IEVL 593
V+ N+M+ NLA FGP LL RP S L SA D H ++VL
Sbjct: 745 VAEKEPINKMSLHNLATVFGPTLL-------RPSEVESKAHLTSAADIWSHDVMAQVQVL 797
Query: 594 HYLLQSWP 601
Y LQ P
Sbjct: 798 LYYLQHPP 805
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 117 bits (294), Expect = 3e-26
Identities = 82/229 (35%), Positives = 121/229 (52%), Gaps = 15/229 (6%)
Query: 388 PATAEPRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKEL 447
P+ + VFG+ + ++ +RER +VP I+++CV +IERRG+ VG+YR+ G A + L
Sbjct: 1000 PSRKQTGVFGVKIAVVTKRER--SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQAL 1057
Query: 448 RDAFERDS--AAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPN 505
+ AF+ ++ +V +SE D+N I G LK Y RELP PL T Y E +A P
Sbjct: 1058 KAAFDVNNKDVSVMMSE---MDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDP- 1113
Query: 506 RVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPAR 565
LL LP+ T LLDHL+ V+ A N+M+ NLA FGP LL
Sbjct: 1114 --VAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPS 1171
Query: 566 QAPTRPRARSSGPGLAS---AVDFKHHIEVLHYLLQ--SWPDPRLPRQS 609
+ ++ A S P + +++ ++VL Y LQ + P P RQS
Sbjct: 1172 EKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQS 1220
Score = 31.2 bits (69), Expect = 3.6
Identities = 37/159 (23%), Positives = 53/159 (33%), Gaps = 21/159 (13%)
Query: 33 AQRPEPSPPEPEPQAPEGSQAGAEGPSSP------EASRSPARGAYLQSLEPSSR----- 81
AQ P+ PP E ++ + E + E ++ R YLQ+L +
Sbjct: 13 AQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDR 72
Query: 82 -RWVLGGAKPAEDTSLGPGVPGTGEP-AGEIWYNPIPEEDPRPPAPEPPGPQPGSAESEG 139
RW A A D G EP A P P + PP E P +P S G
Sbjct: 73 QRWGFRRAAQAPD--------GASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPG 124
Query: 140 LAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRR 178
A G A + GP ++ +R+
Sbjct: 125 KARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRK 163
Score = 31.2 bits (69), Expect = 3.6
Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 11/74 (14%)
Query: 7 RKTFSRLR-GREKLPRKKSDAKERGHPAQRPEPSP-------PEPEPQA-PEGSQAGAEG 57
+K++ R R G + + A E A RP+P+P P EP+A P+G G+ G
Sbjct: 67 KKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE--GSPG 124
Query: 58 PSSPEASRSPARGA 71
+ P +R P A
Sbjct: 125 KARPGTARRPGAAA 138
>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
Length = 1136
Score = 103 bits (258), Expect = 4e-22
Identities = 77/207 (37%), Positives = 100/207 (48%), Gaps = 29/207 (14%)
Query: 410 PGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDIN 469
P VP I++KCV +IERR LR G+YR+ G ++L AFE V LS+ D
Sbjct: 771 PDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHD-- 828
Query: 470 VITGILKDYLRELPTPLITQPLY-----------KVVLEAMARDPPNRVPPTTEGT---- 514
I+ +LK YLR+LP PLI+ LY K EA A + +E
Sbjct: 829 -ISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVAL 887
Query: 515 ----RGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTR 570
R LL LP RA+L LL HLR + N+MTP NL + FGP LL R
Sbjct: 888 AGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLL-------R 940
Query: 571 PRARSSGPGLASAVDFKHHIEVLHYLL 597
PR + L+S VD+ H V+ L+
Sbjct: 941 PRPTEATVSLSSLVDYPHQARVIETLI 967
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 103 bits (258), Expect = 4e-22
Identities = 57/150 (38%), Positives = 84/150 (56%), Gaps = 5/150 (3%)
Query: 414 PLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITG 473
P+++ C+ +IE RGL GLYR+ G + + ++++ AF+RD +S ++Y DIN+ITG
Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341
Query: 474 ILKDYLRELPTPLITQPLY-KVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLL 532
LK Y R+LP PLIT Y K + A DP ++ E L LP TL L
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEA----LKLLPPAHCETLRYL 397
Query: 533 LDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
+ HL+ V+ N M +NL + FGP L+
Sbjct: 398 MAHLKRVTLHEKENLMNAENLGIVFGPTLM 427
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 103 bits (258), Expect = 4e-22
Identities = 57/150 (38%), Positives = 84/150 (56%), Gaps = 5/150 (3%)
Query: 414 PLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITG 473
P+++ C+ +IE RGL GLYR+ G + + ++++ AF+RD +S ++Y DIN+ITG
Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315
Query: 474 ILKDYLRELPTPLITQPLY-KVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLL 532
LK Y R+LP PLIT Y K + A DP ++ E L LP TL L
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEA----LKLLPPAHCETLRYL 371
Query: 533 LDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
+ HL+ V+ N M +NL + FGP L+
Sbjct: 372 MAHLKRVTLHEKENLMNAENLGIVFGPTLM 401
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 102 bits (255), Expect = 1e-21
Identities = 64/169 (37%), Positives = 95/169 (56%), Gaps = 7/169 (4%)
Query: 394 RVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFER 453
+VFG L L +RE G VP ++ C+ +E GL + G+YR+ G+ AV ++LR A
Sbjct: 652 QVFGSNLANLCQREN--GTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNH 709
Query: 454 DSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEG 513
D + L++ + DI+VITG LK + RELP PL T + + A+ ++P RV
Sbjct: 710 DEK-LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRV----AA 764
Query: 514 TRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
+ L+ LP + T+ +L HLR V NRMT Q++A+ FGP LL
Sbjct: 765 VKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLL 813
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 101 bits (252), Expect = 2e-21
Identities = 55/151 (36%), Positives = 83/151 (54%), Gaps = 3/151 (1%)
Query: 412 QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVI 471
Q P+++ C+ +IE RGL+ GLYR+ G ++++ AF+RD +S ++YPDIN+I
Sbjct: 289 QRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINII 348
Query: 472 TGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTL 531
TG LK Y R+LP P+IT Y ++A + E +L LP TL
Sbjct: 349 TGALKLYFRDLPIPVITYDTYSKFIDAA---KISNADERLEAVHEVLMLLPPAHYETLRY 405
Query: 532 LLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
L+ HL+ V+ N M +NL + FGP L+
Sbjct: 406 LMIHLKKVTMNEKDNFMNAENLGIVFGPTLM 436
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 101 bits (252), Expect = 2e-21
Identities = 55/151 (36%), Positives = 83/151 (54%), Gaps = 3/151 (1%)
Query: 412 QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVI 471
Q P+++ C+ +IE RGL+ GLYR+ G ++++ AF+RD +S ++YPDIN+I
Sbjct: 153 QRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINII 212
Query: 472 TGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTL 531
TG LK Y R+LP P+IT Y ++A + E +L LP TL
Sbjct: 213 TGALKLYFRDLPIPVITYDTYSKFIDAA---KISNADERLEAVHEVLMLLPPAHYETLRY 269
Query: 532 LLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
L+ HL+ V+ N M +NL + FGP L+
Sbjct: 270 LMIHLKKVTMNEKDNFMNAENLGIVFGPTLM 300
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 101 bits (252), Expect = 2e-21
Identities = 75/228 (32%), Positives = 112/228 (49%), Gaps = 10/228 (4%)
Query: 335 AWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPR 394
+W RP A L P G ++ VR + + L + TL +E + +
Sbjct: 270 SWQEKEEDARPNAAAPALGPV---GLESDLSKVRHKLRKFLQRRPTLQSLREK-GYIKDQ 325
Query: 395 VFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERD 454
VFG L L ERER +VP +Q+C+ +E RGL + GLYR+ G+ A ++LR + D
Sbjct: 326 VFGCALAALCERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD 383
Query: 455 SAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGT 514
+ L + + D++VITG LK + RELP PL ++ + A+ R +
Sbjct: 384 E-RLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQAR---RSRCV 439
Query: 515 RGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
R L+ LP TL +L HL V NRM+ Q++A+ FGP LL
Sbjct: 440 RDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLL 487
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 101 bits (252), Expect = 2e-21
Identities = 75/228 (32%), Positives = 112/228 (49%), Gaps = 10/228 (4%)
Query: 335 AWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPR 394
+W RP A L P G ++ VR + + L + TL +E + +
Sbjct: 297 SWQEKEEDARPNAAAPALGPV---GLESDLSKVRHKLRKFLQRRPTLQSLREK-GYIKDQ 352
Query: 395 VFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERD 454
VFG L L ERER +VP +Q+C+ +E RGL + GLYR+ G+ A ++LR + D
Sbjct: 353 VFGCALAALCERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHD 410
Query: 455 SAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGT 514
+ L + + D++VITG LK + RELP PL ++ + A+ R +
Sbjct: 411 E-RLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQAR---RSRCV 466
Query: 515 RGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
R L+ LP TL +L HL V NRM+ Q++A+ FGP LL
Sbjct: 467 RDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLL 514
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 99.4 bits (246), Expect = 1e-20
Identities = 63/178 (35%), Positives = 93/178 (52%), Gaps = 16/178 (8%)
Query: 391 AEPRVFGLPLPLLVERERPPGQ---VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKEL 447
A PR FG+ L E +P + VPLI+ C +E RGL G+YR+ G+ AV L
Sbjct: 804 AAPRAFGVRL----EECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSL 859
Query: 448 RDAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRV 507
++ R + L ++ + D+NVI+ +LK + R+LP PL T Y +EA NR+
Sbjct: 860 QEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEA------NRI 913
Query: 508 PPTTE---GTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
E R L+ LP TL L+ HL+ ++ N+M P+NLA+ FGP L+
Sbjct: 914 EDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLV 971
Score = 39.3 bits (90), Expect = 0.013
Identities = 44/146 (30%), Positives = 63/146 (43%), Gaps = 21/146 (14%)
Query: 122 PPAPEPPGPQPGSAESEGLAPQGAAPASPPTK--ASRTKSPGPA-RRLSIKMKK--LPEL 176
P APEPPG S+ E L P AA AS P++ A R + G A L++++++ PE
Sbjct: 1244 PRAPEPPG-SASSSSQESLRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPET 1302
Query: 177 RRRLSLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSP 236
RRR S + R + ++ +GG GP P G R+ S
Sbjct: 1303 RRRRS-----SWRRHTVVVQSPLTDLNFNEWKELGGGGPPE-PAGARA---------HSD 1347
Query: 237 ERPAGPPSPTSFRPYEVGPAARAPPA 262
+ +G S S + AA PPA
Sbjct: 1348 NKDSGLSSLESTKARAPSSAASQPPA 1373
Score = 31.2 bits (69), Expect = 3.6
Identities = 29/97 (29%), Positives = 36/97 (37%), Gaps = 15/97 (15%)
Query: 204 YHLDSSVGGPGPAAG-------PGGTRSPRAGYLSDGDSPERPAGPPSPTSFRPYEV--- 253
Y D+ + G P +G P PR Y + R P PTS P +
Sbjct: 69 YSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSP 128
Query: 254 ----GPAARAPPAALWGRLSLHLYGLGGLRPAPGATP 286
P R PPAA L G+ RP+PGA P
Sbjct: 129 AAWSDPGLRVPPAAR-AHLDNSSLGMSQPRPSPGAFP 164
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 99.4 bits (246), Expect = 1e-20
Identities = 74/234 (31%), Positives = 111/234 (47%), Gaps = 23/234 (9%)
Query: 363 QQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKCVG 422
+Q VR + + L+ + L QE + +VFG L L +RE VP ++ C+
Sbjct: 489 EQNRVRNKLKRLIAKRPPLQSLQERGLLRD-QVFGCQLESLCQREGDT--VPSFLRLCIA 545
Query: 423 QIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYP---------------- 466
+++RGL V G+YR+ G+ AV ++LR +R+ A ++P
Sbjct: 546 AVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEW 605
Query: 467 -DINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVE 525
DI+V+TG LK +LRELP PL+ L A+A + + L+ +P
Sbjct: 606 DDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQC---LSQIQELIGSMPKPN 662
Query: 526 RATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPG 579
TL LL+HL V + NRMTP NL + FGP L Q + P A + PG
Sbjct: 663 HDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPG 716
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 99.4 bits (246), Expect = 1e-20
Identities = 74/234 (31%), Positives = 111/234 (47%), Gaps = 23/234 (9%)
Query: 363 QQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKCVG 422
+Q VR + + L+ + L QE + +VFG L L +RE VP ++ C+
Sbjct: 305 EQNRVRNKLKRLIAKRPPLQSLQERGLLRD-QVFGCQLESLCQREGDT--VPSFLRLCIA 361
Query: 423 QIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYP---------------- 466
+++RGL V G+YR+ G+ AV ++LR +R+ A ++P
Sbjct: 362 AVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEW 421
Query: 467 -DINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVE 525
DI+V+TG LK +LRELP PL+ L A+A + + L+ +P
Sbjct: 422 DDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQC---LSQIQELIGSMPKPN 478
Query: 526 RATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPG 579
TL LL+HL V + NRMTP NL + FGP L Q + P A + PG
Sbjct: 479 HDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPG 532
>gi|91208437 GEM interacting protein [Homo sapiens]
Length = 970
Score = 99.0 bits (245), Expect = 1e-20
Identities = 81/252 (32%), Positives = 116/252 (46%), Gaps = 29/252 (11%)
Query: 410 PGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDIN 469
P +VP ++ KC +IE R L V G+YR+ GS + L AFE A V LS + D
Sbjct: 561 PEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELSGNSPHD-- 618
Query: 470 VITGILKDYLRELPTPLITQPLYKV------VLEAMARDPPNRVPPTTEGTRG---LLSC 520
++ +LK +L+EL P+I LY L A D P P+ E R LL
Sbjct: 619 -VSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLLVQ 677
Query: 521 LPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGL 580
LPD TL L+ HL V++ N+M+ NL + FGP LL + P PRA S+ P +
Sbjct: 678 LPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLL---RPPDGPRAASAIP-V 733
Query: 581 ASAVDFKHHIEVLHYLLQSW------------PDPRLPRQSPDVAPYLRPKRQPPLHL-P 627
+D H +++ +L+ + +P SP P + PP HL P
Sbjct: 734 TCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTTSSQPPPPHLDP 793
Query: 628 LADPEVVTRPRG 639
+ P V+ G
Sbjct: 794 DSQPPVLASDPG 805
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 95.5 bits (236), Expect = 2e-19
Identities = 52/151 (34%), Positives = 85/151 (56%), Gaps = 5/151 (3%)
Query: 413 VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVIT 472
+PLI+ C +E RGL G+YR+ G+ A +++ + A + + +D + D+NVI+
Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220
Query: 473 GILKDYLRELPTPLITQPLYKVVLEAMAR-DPPNRVPPTTEGTRGLLSCLPDVERATLTL 531
+LK + R+LP PL T Y +EA + DP +R+ + + L+ LP+ TL
Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRL----KTLKRLIHDLPEHHYETLKF 1276
Query: 532 LLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
L HL+ V+ N+M P+NLA+ FGP L+
Sbjct: 1277 LSAHLKTVAENSEKNKMEPRNLAIVFGPTLV 1307
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 95.1 bits (235), Expect = 2e-19
Identities = 57/171 (33%), Positives = 94/171 (54%), Gaps = 6/171 (3%)
Query: 394 RVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFER 453
++FG L + ERE VP +++C+ +E+RGL V G+YR+ G+ A ++LR +
Sbjct: 277 QIFGSHLHKVCEREN--STVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQ 334
Query: 454 DSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEG 513
+ + L + + DI+V+TG LK + RELP PL ++ +EA+ + N E
Sbjct: 335 EE-KLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNN---TRIEA 390
Query: 514 TRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPA 564
+ L+ LP R T+ +L HL + + + N M+ Q+L + FGP LL A
Sbjct: 391 VKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRA 441
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 92.0 bits (227), Expect = 2e-18
Identities = 76/258 (29%), Positives = 119/258 (46%), Gaps = 23/258 (8%)
Query: 392 EPRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAF 451
E FG+PL LV E+P +PL ++KCV IE GL GLYR+ G+ + ++ F
Sbjct: 1256 ESNYFGMPLQDLVTAEKP---IPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQF 1312
Query: 452 ERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTT 511
++D +S ++ +N + G LK + +LP PLI L+ +LEA ++P T
Sbjct: 1313 DQDHNINLVSMEV--TVNAVAGALKAFFADLPDPLIPYSLHPELLEAA------KIPDKT 1364
Query: 512 EGTRGLLSCLP---DVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL----PA 564
E L + V ++ HL VS H N MT NL++CF P L+
Sbjct: 1365 ERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFEN 1424
Query: 565 RQAPTRPRARSS--GPGLASAVDFKHHIEVLHYL-LQSWPDPRLPRQSPDVAPYLRPKRQ 621
R+ + + S + F ++ E++ + + P P P Q V P + +
Sbjct: 1425 REFLSTTKIHQSVVETFIQQCQFFFYNGEIVETTNIVAPPPPSNPGQL--VEPMVPLQLP 1482
Query: 622 PPLHLPLADPEVVTRPRG 639
PPL L P++ T P G
Sbjct: 1483 PPLQPQLIQPQLQTDPLG 1500
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 92.0 bits (227), Expect = 2e-18
Identities = 76/258 (29%), Positives = 119/258 (46%), Gaps = 23/258 (8%)
Query: 392 EPRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAF 451
E FG+PL LV E+P +PL ++KCV IE GL GLYR+ G+ + ++ F
Sbjct: 1255 ESNYFGMPLQDLVTAEKP---IPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQF 1311
Query: 452 ERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTT 511
++D +S ++ +N + G LK + +LP PLI L+ +LEA ++P T
Sbjct: 1312 DQDHNINLVSMEV--TVNAVAGALKAFFADLPDPLIPYSLHPELLEAA------KIPDKT 1363
Query: 512 EGTRGLLSCLP---DVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL----PA 564
E L + V ++ HL VS H N MT NL++CF P L+
Sbjct: 1364 ERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFEN 1423
Query: 565 RQAPTRPRARSS--GPGLASAVDFKHHIEVLHYL-LQSWPDPRLPRQSPDVAPYLRPKRQ 621
R+ + + S + F ++ E++ + + P P P Q V P + +
Sbjct: 1424 REFLSTTKIHQSVVETFIQQCQFFFYNGEIVETTNIVAPPPPSNPGQL--VEPMVPLQLP 1481
Query: 622 PPLHLPLADPEVVTRPRG 639
PPL L P++ T P G
Sbjct: 1482 PPLQPQLIQPQLQTDPLG 1499
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 89.0 bits (219), Expect = 1e-17
Identities = 72/240 (30%), Positives = 111/240 (46%), Gaps = 18/240 (7%)
Query: 417 IQKCVGQIERRGLRVVGLYRLCG-SAAVKKELRDAFERDSAA-VCLSEDLYPDINVITGI 474
++KC+ +E RG+ ++GLYR+ G ++ V+K + F S + + +L+ D IT
Sbjct: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELW-DNKTITSG 456
Query: 475 LKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLD 534
LK+YLR L PL+T L+K + A+ D N E L+ LP+ R L +L+
Sbjct: 457 LKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNY---RVEAVHALVHKLPEKNREMLDILIK 513
Query: 535 HLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLH 594
HL VS N MT NL V FGP L+ A++ + + +H+ ++ H
Sbjct: 514 HLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFH 573
Query: 595 YLLQSWPDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGP--ESPPSNRYA 652
+ PDP +P P R R L +PRGR P P S+ Y+
Sbjct: 574 ----TAPDPSIPLPQPQSRSGSRRTRAICLSTG------SRKPRGRYTPCLAEPDSDSYS 623
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 88.6 bits (218), Expect = 2e-17
Identities = 64/174 (36%), Positives = 90/174 (51%), Gaps = 15/174 (8%)
Query: 392 EPRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAF 451
EP FG+ + L + VP++++K + +E GL GLYR G+A +ELR A
Sbjct: 1694 EPGHFGVCVDSLTSDK---ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQAL 1750
Query: 452 ERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTT 511
+ D AAV L +P I+ ITG+LK +LRELP PL+T Y L A+ +P
Sbjct: 1751 QTDPAAVKLEN--FP-IHAITGVLKQWLRELPEPLMTFAQYGDFLRAV------ELPEKQ 1801
Query: 512 E---GTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
E +L LP+ +L L+ HL V+ NRM+P LA+ F P LL
Sbjct: 1802 EQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLL 1855
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 88.6 bits (218), Expect = 2e-17
Identities = 64/174 (36%), Positives = 90/174 (51%), Gaps = 15/174 (8%)
Query: 392 EPRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAF 451
EP FG+ + L + VP++++K + +E GL GLYR G+A +ELR A
Sbjct: 1694 EPGHFGVCVDSLTSDK---ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQAL 1750
Query: 452 ERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTT 511
+ D AAV L +P I+ ITG+LK +LRELP PL+T Y L A+ +P
Sbjct: 1751 QTDPAAVKLEN--FP-IHAITGVLKQWLRELPEPLMTFAQYGDFLRAV------ELPEKQ 1801
Query: 512 E---GTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
E +L LP+ +L L+ HL V+ NRM+P LA+ F P LL
Sbjct: 1802 EQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLL 1855
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 87.4 bits (215), Expect = 4e-17
Identities = 50/174 (28%), Positives = 85/174 (48%), Gaps = 8/174 (4%)
Query: 389 ATAEPRVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELR 448
AT E FG+PL +V E+P +P+ I++C+ IE GL G+YR+ G+ + + L+
Sbjct: 1240 ATWESNYFGVPLTTVVTPEKP---IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQ 1296
Query: 449 DAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVP 508
F++D +D +N + G +K + ELP PL+ Y + ++ + N
Sbjct: 1297 RQFDQDHNLDLAEKDF--TVNTVAGAMKSFFSELPDPLVP---YNMQIDLVEAHKINDRE 1351
Query: 509 PTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
+ +L P ++ HL VS + N MT +NL++CF P L+
Sbjct: 1352 QKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLM 1405
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 87.4 bits (215), Expect = 4e-17
Identities = 60/172 (34%), Positives = 88/172 (51%), Gaps = 15/172 (8%)
Query: 394 RVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFER 453
R FG+ L L +R VPL+++K + IE GL G+YR GS KELR +
Sbjct: 2059 RQFGVELSRLTSEDRT---VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDT 2115
Query: 454 DSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEG 513
D+ +V L + +I+VI + K +LR+LP PL+T LY+ L AM + E
Sbjct: 2116 DAESVNLDD---YNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMG------LQERKET 2166
Query: 514 TRGLLSCLPDVERA---TLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLL 562
RG+ S + + R TL L+ HL ++ NRM+ LA+ F P +L
Sbjct: 2167 IRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCIL 2218
>gi|239757488 PREDICTED: chromosome 20 open reading frame 95 [Homo
sapiens]
Length = 622
Score = 87.0 bits (214), Expect = 6e-17
Identities = 69/216 (31%), Positives = 108/216 (50%), Gaps = 10/216 (4%)
Query: 391 AEPRVFGLPLPLLVERER---PPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKEL 447
AE R+FG+PL L+E + P QVPL++Q + +E+RGL + G+ R+ GS A K L
Sbjct: 263 AETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGL 322
Query: 448 RDAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRV 507
ERD A S D N + +LK ++R+LPTPL+T A+ + PN +
Sbjct: 323 EQKLERDFYAGLFSWDEVHH-NDASDLLKRFIRKLPTPLLTAEYLPAF--AVVPNIPN-L 378
Query: 508 PPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGP-VLLPARQ 566
+ L+ LP+ R L LL+ LR V + +N+MT +N++ P + L +
Sbjct: 379 KQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGR 438
Query: 567 APTRPRARSS--GPGLASAVDFKHHIEVLHYLLQSW 600
P P+ + G A V H + L + + S+
Sbjct: 439 PPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASF 474
>gi|239752003 PREDICTED: chromosome 20 open reading frame 95 [Homo
sapiens]
Length = 622
Score = 87.0 bits (214), Expect = 6e-17
Identities = 69/216 (31%), Positives = 108/216 (50%), Gaps = 10/216 (4%)
Query: 391 AEPRVFGLPLPLLVERER---PPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKEL 447
AE R+FG+PL L+E + P QVPL++Q + +E+RGL + G+ R+ GS A K L
Sbjct: 263 AETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGL 322
Query: 448 RDAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRV 507
ERD A S D N + +LK ++R+LPTPL+T A+ + PN +
Sbjct: 323 EQKLERDFYAGLFSWDEVHH-NDASDLLKRFIRKLPTPLLTAEYLPAF--AVVPNIPN-L 378
Query: 508 PPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGP-VLLPARQ 566
+ L+ LP+ R L LL+ LR V + +N+MT +N++ P + L +
Sbjct: 379 KQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGR 438
Query: 567 APTRPRARSS--GPGLASAVDFKHHIEVLHYLLQSW 600
P P+ + G A V H + L + + S+
Sbjct: 439 PPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASF 474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,339,248
Number of Sequences: 37866
Number of extensions: 2817865
Number of successful extensions: 37519
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 384
Number of HSP's successfully gapped in prelim test: 1869
Number of HSP's that attempted gapping in prelim test: 19968
Number of HSP's gapped (non-prelim): 11925
length of query: 735
length of database: 18,247,518
effective HSP length: 110
effective length of query: 625
effective length of database: 14,082,258
effective search space: 8801411250
effective search space used: 8801411250
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.