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Search of human proteins with 41872583
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41872583 Rho-associated, coiled-coil containing protein
kinase 2 [Homo sapiens]
(1388 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 2750 0.0
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 1765 0.0
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 465 e-130
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 458 e-128
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 451 e-126
gi|32698688 citron [Homo sapiens] 436 e-121
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 419 e-116
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 365 e-100
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 365 e-100
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 362 2e-99
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 343 5e-94
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 226 2e-58
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 224 3e-58
gi|4826948 protein kinase, X-linked [Homo sapiens] 221 5e-57
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 219 1e-56
gi|148727255 microtubule associated serine/threonine kinase fami... 216 9e-56
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 216 1e-55
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 215 3e-55
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 215 3e-55
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 214 5e-55
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 213 1e-54
gi|4885563 protein kinase C, epsilon [Homo sapiens] 206 1e-52
gi|5453976 protein kinase C, theta [Homo sapiens] 200 9e-51
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 199 1e-50
gi|239752561 PREDICTED: similar to Rho-associated, coiled-coil c... 197 8e-50
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 196 2e-49
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 196 2e-49
gi|28557781 protein kinase C, eta [Homo sapiens] 195 3e-49
gi|4502023 AKT2 kinase [Homo sapiens] 194 5e-49
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 193 8e-49
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 2750 bits (7129), Expect = 0.0
Identities = 1388/1388 (100%), Positives = 1388/1388 (100%)
Query: 1 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP 60
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
Sbjct: 1 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP 60
Query: 61 ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM 120
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
Sbjct: 61 ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM 120
Query: 121 KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL 180
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
Sbjct: 121 KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL 180
Query: 181 MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD 240
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
Sbjct: 181 MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD 240
Query: 241 ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV 300
ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV
Sbjct: 241 ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV 300
Query: 301 GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH 360
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
Sbjct: 301 GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH 360
Query: 361 WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL 420
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
Sbjct: 361 WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL 420
Query: 421 LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT 480
LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT
Sbjct: 421 LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT 480
Query: 481 AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL 540
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
Sbjct: 481 AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL 540
Query: 541 EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR 600
EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR
Sbjct: 541 EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR 600
Query: 601 DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKI 660
DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKI
Sbjct: 601 DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKI 660
Query: 661 LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK 720
LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK
Sbjct: 661 LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK 720
Query: 721 IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLK 780
IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLK
Sbjct: 721 IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLK 780
Query: 781 QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMN 840
QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMN
Sbjct: 781 QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMN 840
Query: 841 LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK 900
LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK
Sbjct: 841 LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK 900
Query: 901 KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE 960
KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE
Sbjct: 901 KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE 960
Query: 961 LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQF 1020
LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQF
Sbjct: 961 LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQF 1020
Query: 1021 EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQ 1080
EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQ
Sbjct: 1021 EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQ 1080
Query: 1081 MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPG 1140
MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPG
Sbjct: 1081 MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPG 1140
Query: 1141 DAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL 1200
DAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL
Sbjct: 1141 DAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL 1200
Query: 1201 DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKG 1260
DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKG
Sbjct: 1201 DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKG 1260
Query: 1261 HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD 1320
HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD
Sbjct: 1261 HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD 1320
Query: 1321 ISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR 1380
ISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR
Sbjct: 1321 ISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR 1380
Query: 1381 QLAPNKPS 1388
QLAPNKPS
Sbjct: 1381 QLAPNKPS 1388
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 1765 bits (4571), Expect = 0.0
Identities = 892/1358 (65%), Positives = 1093/1358 (80%), Gaps = 27/1358 (1%)
Query: 25 SRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRG 84
+R K++ L+RDP+S +N + LLDGL++LV DLDFPALRKNKNIDNFL+RY+ + KIR
Sbjct: 9 TRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRD 68
Query: 85 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 144
L+MKAEDY+VVKVIGRGAFGEVQLVRHK+++KVYAMKLLSKFEMIKRSDSAFFWEERDIM
Sbjct: 69 LRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIM 128
Query: 145 AFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDA 204
AFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWA+FYTAEVVLALDA
Sbjct: 129 AFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDA 188
Query: 205 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 264
IHSMG IHRDVKPDNMLLDK GHLKLADFGTCMKM++ GMV CDTAVGTPDYISPEVLKS
Sbjct: 189 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS 248
Query: 265 QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKH 324
QGGDG+YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM+HKNSL FP+D +ISK
Sbjct: 249 QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKE 308
Query: 325 AKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNF 384
AKNLICAFLTDREVRLGRNGVEEI++H FFKNDQW W+ +R+T APVVP+LSSDID+SNF
Sbjct: 309 AKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNF 368
Query: 385 DDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSD-SPSCRETDSIQSRKNEESQ 443
DD+E+DKG+ ETFPIPKAFVGNQLPF+GFTYY LS +P+ T S + +ES
Sbjct: 369 DDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQES- 427
Query: 444 EIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLER 503
+QK +Y LEE L NEMQ K+E+EQKC++ N +L+K KEL+EE R+++ES + Q+E+
Sbjct: 428 -LQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEK 486
Query: 504 EKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQ 563
EK LLQH+ EYQRKA+ E +K+RN+EN+V++LKDQLEDLKK +QNSQ++ EK++QLQ+Q
Sbjct: 487 EKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQ 546
Query: 564 LDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINL 623
L+E N LLRTESDTA RLRK+ E SK I QLES NR+LQ++N +LE +K + +K++ L
Sbjct: 547 LEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQL 606
Query: 624 QSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEK 683
Q+ LE+ERRDR H SE+I DLQ RI L+E++K+ K L KVE E+++ Q+ EKEK
Sbjct: 607 QAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEK 666
Query: 684 SNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEE 743
+N+EID+ Y+LK +QQ LEQE EHK TKARL DK ++SIEEAKS AM EMEKKL EE
Sbjct: 667 NNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDK---HQSIEEAKSVAMCEMEKKLKEE 723
Query: 744 RTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKR 803
R ++K EN +++ EK+CS+LD DLKQSQQK+ L K+ + ++V+NLTL++EQE+ KR
Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783
Query: 804 CLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQ 863
L QN+LK Q + + LK EKQ+KQE N L+E K LE + A+L K+ + +GQM+ELQ
Sbjct: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843
Query: 864 DQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKAD 923
DQLEAEQYFSTLYKTQV+ELKEE EEK +E +K QELQ+E+++LA QL++ TKA+
Sbjct: 844 DQLEAEQYFSTLYKTQVKELKEEIEEK---NRENLKKIQELQNEKETLATQLDLAETKAE 900
Query: 924 SEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVA 983
SEQLAR + EEQY +L +E K+ +R++QE+T+KD T++ LEE N LT D+
Sbjct: 901 SEQLARGLLEEQYFELTQES-------KKAASRNRQEITDKDHTVSRLEEANSMLTKDIE 953
Query: 984 NLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMN 1043
L E EEL K+K +E+ K+EEIS +KA FEK + TERTLKTQAVNKLAEIMN
Sbjct: 954 ILRRENEELTEKMKKAEEEYKLEKEEEIS--NLKAAFEKNINTERTLKTQAVNKLAEIMN 1011
Query: 1044 RKE---PVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQ 1100
RK+ K+ N D+R+KEKENRKL +EL EREK Q ++K+QKELN+MQAQ+ EE
Sbjct: 1012 RKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECA 1071
Query: 1101 IRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLP 1160
R ELQM L SK+SDIEQLR++L L DS+S+ S P E D PESR+EGWLS+P
Sbjct: 1072 HRNELQMQLASKESDIEQLRAKLLDLS---DSTSVASFPSADETDGNLPESRIEGWLSVP 1128
Query: 1161 VRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRAD 1220
R N K++GW K+YV+VSSKKILFY+ EQDKEQSNP MVLDIDKLFHVRPVTQ DVYRA+
Sbjct: 1129 NRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAE 1188
Query: 1221 AKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKP 1280
+EIP+IFQILYANEGE +K+ E EK+N+ HKGHEFIPTLYHFP NC+AC KP
Sbjct: 1189 TEEIPKIFQILYANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKP 1248
Query: 1281 LWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKW 1340
LWH+FKPPPALECRRCH+KCH+DH+DKKE++I PCKV YD+++A+++LLLA S +EQ+KW
Sbjct: 1249 LWHVFKPPPALECRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKW 1308
Query: 1341 VSRLVKKIPKKPPAPDPFARSSPRT-SMKIQQNQSIRR 1377
V+ LVKKIPK PP+ F R+SPRT S + NQS R+
Sbjct: 1309 VTHLVKKIPKNPPS--GFVRASPRTLSTRSTANQSFRK 1344
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 465 bits (1196), Expect = e-130
Identities = 329/1042 (31%), Positives = 555/1042 (53%), Gaps = 96/1042 (9%)
Query: 26 RQRKLEALIRDP----RSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKK 81
R +KLE L+ D S ++VE+LLD L L + ALR++K + FL + +
Sbjct: 6 RLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQL 65
Query: 82 IRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEER 141
++ +Q+ ED++++KVIGRGAFGEV +V+ K ++++YAMK+L+K+EM+KR+++A F EER
Sbjct: 66 VKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREER 125
Query: 142 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVV 199
D++ + W+ L YAFQD+ +LY+VM+Y GGDL+ L+S ++ +PE A+FY E+V
Sbjct: 126 DVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 185
Query: 200 LALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISP 259
LA+D+IH + +HRD+KPDN+LLD +GH++LADFG+C+KM++ G V AVGTPDYISP
Sbjct: 186 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISP 245
Query: 260 EVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPED 318
E+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIM+H+ FP
Sbjct: 246 EILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSH 305
Query: 319 -AEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSS 377
++S+ AK+LI + RE RLG+NG+E+ ++H FF+ +W+NIR AP +P++SS
Sbjct: 306 VTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEG--LNWENIRNLEAPYIPDVSS 363
Query: 378 DIDSSNFDDIEDDKGDVETFP--IPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQ 435
D+SNFD +D + E P F G LPFIGFT+ E+ SD S + +Q
Sbjct: 364 PSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTES-CFSDRGSLKSI--MQ 420
Query: 436 SRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVE 495
S + +++Q+ L EH S +M+A E ++ + L + +E + +
Sbjct: 421 SNTLTKDEDVQRDL----EH-SLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSS 475
Query: 496 SALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTE 555
AL R+K + +K + E ++ +N D N L+ QLED Q + ST+
Sbjct: 476 RALSNSNRDKEI---------KKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQ 526
Query: 556 KVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLK 615
++ L++Q + ++R E + L K E+S ++L+S ++L+D + + KL
Sbjct: 527 RLRGLEKQ----HRVVRQEKE---ELHKQLVEAS---ERLKSQAKELKDAH---QQRKLA 573
Query: 616 LEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQER 675
L+ EF L + R + S + D EE+++ + + E R+ ++
Sbjct: 574 LQ-EFSELNERMAELRAQKQKVSRQLRD-------KEEEMEVATQKVDAMRQEMRRAEKL 625
Query: 676 FTDLEKEKSNMEIDMTYQLKVIQQS---LEQEEAEHKATKARLADK--NKIYESIEEAKS 730
+LE + + + + + K+ + S +Q E+E +A K + + E +E S
Sbjct: 626 RKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEI-S 684
Query: 731 EAMKEMEKKLL--EERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNED 788
+ E+EKK+L EE ++++ ++L + + D + Q + E+L KD L +
Sbjct: 685 KIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQ-KEILMLKDKLEKS 743
Query: 789 VRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSE-KQLKQENNHLMEMKMNLEKQNAE 847
R ++E+ +K + ++ + E K+L EN L L QN +
Sbjct: 744 KRERHNEMEEAV-------GTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQ 796
Query: 848 LRKERQDA----------DGQMKEL----QDQLEAEQYFSTLYKTQVRELKEECEEKTKL 893
L E QD + Q+ E+ D+ +A Y L EL E + L
Sbjct: 797 LEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEEL--EALRSSSL 854
Query: 894 G-KELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKE 952
G + L + + ++ ++A+LE+ + ++E A+ + +E+ ++ + E ++K+
Sbjct: 855 GSRTLDPLWKVRRSQKLDMSARLELQ-SALEAEIRAKQLVQEELRKVKDANLTLESKLKD 913
Query: 953 MMARHKQELTEKDATIASLEETNRTLTS-----------DVANLANEKEELNNKLKDVQE 1001
A++++ L E + +EE R T + N A +L + E
Sbjct: 914 SEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASE 973
Query: 1002 QLSRLKDEEISAAAIKAQFEKQ 1023
Q ++ E S + A E+Q
Sbjct: 974 QETQAPKPEASPSMSVAASEQQ 995
Score = 85.5 bits (210), Expect = 3e-16
Identities = 112/536 (20%), Positives = 246/536 (45%), Gaps = 82/536 (15%)
Query: 628 ESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNME 687
E +RD H ++ + RI LE++ K+ L++ E Q + + SN
Sbjct: 428 EDVQRDLEHSLQM-EAYERRIRRLEQE----KLELSRKLQESTQTVQSLHGSSRALSNSN 482
Query: 688 IDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIE---------EAKSEAMKEMEK 738
D ++K + + +E+ K ++AD N++ +E E ++ ++ +EK
Sbjct: 483 RDK--EIKKLNEEIER-------LKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEK 533
Query: 739 KLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQ 798
+ R K+++ L+EA +R +LK + Q+ L++ LNE + L + ++
Sbjct: 534 QHRVVRQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQK 593
Query: 799 ETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQ 858
+++ + ++++ TQ+V+ ++ ++ ++ L + + ++ RK R+ ++
Sbjct: 594 VSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENF 653
Query: 859 MKELQDQLEAEQYF-------STL-YKTQVRELKEECEEKTKLGKE------------LQ 898
K+++ +LEA + +TL ++ ++ ++K E E+K +E ++
Sbjct: 654 CKQMESELEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVK 713
Query: 899 QKKQELQD-ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE------KEKIMKELEIK 951
K+E+ D E LA Q EI + K E+ R E+++++E K+K +E +
Sbjct: 714 NVKKEVHDSESHQLALQKEILMLKDKLEKSKR----ERHNEMEEAVGTIKDKYERE---R 766
Query: 952 EMMARHKQELTEKDATIAS----LEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLK 1007
M+ ++LT ++ + S L NR L ++ +LA +KE + + + E + +
Sbjct: 767 AMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVS 826
Query: 1008 DEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLH 1067
DE+ + ++A L ++ T + +A+ + +P+ + VRR +K +
Sbjct: 827 DEKDARGYLQA-----LASKMTEELEALRSSSLGSRTLDPLWK-----VRRSQKLDMSAR 876
Query: 1068 MELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQL 1123
+EL+S E + Q+EL +++ + +TL+SK D E +L
Sbjct: 877 LELQSALEAEIRAKQLVQEELRKVK-----------DANLTLESKLKDSEAKNREL 921
Score = 46.6 bits (109), Expect = 2e-04
Identities = 88/385 (22%), Positives = 156/385 (40%), Gaps = 73/385 (18%)
Query: 907 ERDSLAAQLEI-TLTKADSEQ--LARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTE 963
+R SL + ++ TLTK + Q L S+ E Y E+ ++ LE +++ K L E
Sbjct: 411 DRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAY-----ERRIRRLEQEKLELSRK--LQE 463
Query: 964 KDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQ 1023
T+ SL ++R L+ N +KE +K + E++ RLK++ + ++ Q E
Sbjct: 464 STQTVQSLHGSSRALS----NSNRDKE-----IKKLNEEIERLKNKIADSNRLERQLEDT 514
Query: 1024 --LLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQM 1081
L ER TQ + RG + R +E +LH +L E+L Q
Sbjct: 515 VALRQEREDSTQRL--------------RGLEKQHRVVRQEKEELHKQLVEASERLKSQA 560
Query: 1082 IKYQ----------KELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLD 1131
+ + +E +E+ ++AE + ++ L K+ ++E ++ A+ +
Sbjct: 561 KELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMR 620
Query: 1132 SSSIGSGPGDAEADDGFPESRLEGWL----------------SLPVRNNTKKFG------ 1169
+ +A+ DD E+ E L +L V+ + G
Sbjct: 621 RAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQ 680
Query: 1170 -WVKKYVIVSSKKILFYDSE-QDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRI 1227
+ K KK+LFY+ E +E S+ V ++ K H Q A KEI +
Sbjct: 681 QEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQL----ALQKEILML 736
Query: 1228 FQILYANEGESKKEQEFPVEPVGEK 1252
L ++ E E E V + +K
Sbjct: 737 KDKLEKSKRERHNEMEEAVGTIKDK 761
Score = 40.4 bits (93), Expect = 0.012
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 1154 EGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYM---VLDI-DKLFHVR 1209
+G + +P KK GW + Y +V K+ YD + K + VLD+ D F V
Sbjct: 1099 KGHVKVPKPTGVKK-GWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVS 1157
Query: 1210 PVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPV--EPVGEKSNYI 1256
V +DV A ++IP IF++ + G K + E EK ++
Sbjct: 1158 SVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENENEKRKWV 1206
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 458 bits (1178), Expect = e-128
Identities = 320/1002 (31%), Positives = 532/1002 (53%), Gaps = 116/1002 (11%)
Query: 22 AGASRQRKLEALIRDPRSPIN-----VESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYE 76
+G R R+LE I D + N VE+LLD L L + + LR+ KNI +L +
Sbjct: 2 SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAK 61
Query: 77 KIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAF 136
K++ +++ ED++++KVIGRGAFGEV +V+ K + KV+AMK+L+K+EM+KR+++A
Sbjct: 62 PFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC 121
Query: 137 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFY 194
F EERD++ ++ W+ L YAFQDD LY+VM+Y GGDL+ L+S ++ +PE A+FY
Sbjct: 122 FREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFY 181
Query: 195 TAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTP 254
AE+V+A+D++H + +HRD+KPDN+L+D +GH++LADFG+C+K+ E G V AVGTP
Sbjct: 182 LAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 241
Query: 255 DYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSL 313
DYISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIM+HK
Sbjct: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
Query: 314 CFP-EDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVV 372
FP + ++S++AK+LI + RE RLG+NG+E+ ++HPFF WDNIR AP +
Sbjct: 302 QFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID--WDNIRNCEAPYI 359
Query: 373 PELSSDIDSSNFDDIEDDKGDVETFPIP--KAFVGNQLPFIGFTYYRENLLLSDSPSCRE 430
PE+SS D+SNFD +D + ET P P AF G+ LPF+GFT Y + +LSD R
Sbjct: 360 PEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFT-YTSSCVLSDRSCLRV 418
Query: 431 T-----------------------------DSIQSRKNEESQEIQKKLYTLE----EHLS 457
T ++ K E S+++Q+ T++ +
Sbjct: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVD 478
Query: 458 NEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVE--SALRQLEREKALLQHKNAEY 515
+ A ++LE K++ +EK K++ E L + +E +A+RQ E + A Q K E
Sbjct: 479 GPLTASKDLE--IKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQ-ELDDAFRQIKAYEK 535
Query: 516 QRKA--DHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRT 573
Q K D + L LK+Q ++LK + +++ ++ ++ +L E L T
Sbjct: 536 QIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTE----LHT 591
Query: 574 ESDTAAR-LRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERR 632
+ AR +R + E +Q++ES ++L+ E AK +LE L + +R+
Sbjct: 592 QKQKLARHVRDKEEEVDLVMQKVESLRQELR----RTERAKKELEVHTEALAAEASKDRK 647
Query: 633 DRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTY 692
R L+ + GL++ + + +E ++++ + TDLEK+ E
Sbjct: 648 LREQSEHYSKQLENELEGLKQKQISYSPGVCSIE-HQQEITKLKTDLEKKSIFYE----- 701
Query: 693 QLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVEN 752
+ L + E H L K ++++S E + A+ + E LK K+E
Sbjct: 702 ------EELSKREGIHANEIKNL--KKELHDS--EGQQLALNK------EIMILKDKLEK 745
Query: 753 LLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKM 812
E++ + + KQ + ++K +L E+ + LT ++L
Sbjct: 746 TRRESQSEREEFESEFKQQYE------REKVLLTEENKKLT--------------SELDK 785
Query: 813 QTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYF 872
T L + +QL++E L + K ++ A++ + ++ + D+ +A Y
Sbjct: 786 LTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITE-------IIQWVSDEKDARGYL 838
Query: 873 STLYKTQVRELKEECEEKTKLGKELQQKKQELQD-ERDSLAAQLEITLTKADSEQLARSI 931
L EL E + LG +++ + ++A+LE+ + D+E A+
Sbjct: 839 QALASKMTEEL--EALRNSSLGTRATDMPWKMRRFAKLDMSARLELQ-SALDAEIRAKQA 895
Query: 932 AEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEE 973
+E+ + ++ I+ E ++K+ ++ + L+E + I EE
Sbjct: 896 IQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEE 937
Score = 88.6 bits (218), Expect = 4e-17
Identities = 117/560 (20%), Positives = 245/560 (43%), Gaps = 67/560 (11%)
Query: 602 LQDKNCLLETAKLKLEKEFINLQSALES-------ERR------DRTHGSEIINDLQGRI 648
L D++CL TA +N+Q L++ ERR ++ S + + +
Sbjct: 410 LSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTV 469
Query: 649 CGLEEDLKNGKILLAKVELEKRQLQERFTDLEK---EKSNMEIDMTYQLKVIQQSLE--- 702
L+ +G + +K +LE + L+E L K E S++E + + ++Q L+
Sbjct: 470 QALQYSTVDGPLTASK-DLEIKNLKEEIEKLRKQVTESSHLEQQLE-EANAVRQELDDAF 527
Query: 703 -QEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRC 761
Q +A K K ++ + + + +A SE +K K+L + ++ +E +R
Sbjct: 528 RQIKAYEKQIKTLQQEREDLNKELVQA-SERLKNQSKELKDAHCQRKLAMQEFMEINERL 586
Query: 762 SLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLK 821
+ L ++ + + + ++ D++ + V +L QE ++ + +L++ T+ +
Sbjct: 587 TELHTQKQKLARHVRDKEEEVDLVMQKVESL----RQELRRTERAKKELEVHTEALAAEA 642
Query: 822 MSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVR 881
+++L++++ H + LE + L++++ + ++ Q E + + L K +
Sbjct: 643 SKDRKLREQSEHYSKQ---LENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIF 699
Query: 882 ELKEECEEKTKLGKELQQKKQELQD-ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE 940
+E + + E++ K+EL D E LA EI + K E+ R S E
Sbjct: 700 YEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRE------SQSE 753
Query: 941 KEKIMKELEIKEMMARHKQELTEKDATIAS-----------LEETNRTLTSDVANLANEK 989
+E+ E E K+ R K LTE++ + S L N+ L +V +LA++K
Sbjct: 754 REEF--ESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKK 811
Query: 990 EELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVK 1049
E + + + E + + DE+ + ++A K L+ ++ A M K
Sbjct: 812 ESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWK---- 867
Query: 1050 RGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQA-------QIAEESQIR 1102
+RR K + +EL+S + + Q+ELN+++A ++ + +
Sbjct: 868 ------MRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKN 921
Query: 1103 IELQMTLDSKDSDIEQLRSQ 1122
+EL ++ D E+LRS+
Sbjct: 922 LELLSEIEQLIKDTEELRSE 941
Score = 40.0 bits (92), Expect = 0.016
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1154 EGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDI----DKLFHVR 1209
EG + +P KK GW + IV K+ YD + K ++ + D+ F V
Sbjct: 1073 EGHVRIPKPAGVKK-GWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVS 1131
Query: 1210 PVTQTDVYRADAKEIPRIFQI 1230
V +DV A K+IP IF++
Sbjct: 1132 SVLASDVIHASRKDIPCIFRV 1152
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 451 bits (1160), Expect = e-126
Identities = 315/976 (32%), Positives = 518/976 (53%), Gaps = 145/976 (14%)
Query: 22 AGASRQRKLEALIRDPRSPIN-----VESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYE 76
+G R R+LE I D + N VE+LLD L L + + LR+ KNI +L +
Sbjct: 2 SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAK 61
Query: 77 KIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAF 136
K++ +++ ED++++KVIGRGAFGEV +V+ K + KV+AMK+L+K+EM+KR+++A
Sbjct: 62 PFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC 121
Query: 137 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFY 194
F EERD++ ++ W+ L YAFQDD LY+VM+Y GGDL+ L+S ++ +PE A+FY
Sbjct: 122 FREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFY 181
Query: 195 TAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTP 254
AE+V+A+D++H + +HRD+KPDN+L+D +GH++LADFG+C+K+ E G V AVGTP
Sbjct: 182 LAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 241
Query: 255 DYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSL 313
DYISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIM+HK
Sbjct: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
Query: 314 CFP-EDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVV 372
FP + ++S++AK+LI + RE RLG+NG+E+ ++HPFF WDNIR AP +
Sbjct: 302 QFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID--WDNIRNCEAPYI 359
Query: 373 PELSSDIDSSNFDDIEDDKGDVETFPIP--KAFVGNQLPFIGFTYYRENLLLSDSPSCRE 430
PE+SS D+SNFD +D + ET P P AF G+ LPF+GFT Y + +LSD R
Sbjct: 360 PEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFT-YTSSCVLSDRSCLRV 418
Query: 431 TDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITL 490
T S + +Q+ TL+ +L A E E++ K RLE+ EL ++
Sbjct: 419 TAGPTSL--DLDVNVQR---TLDNNL-----ATEAYERRIK----RLEQEKLELSRKLQE 464
Query: 491 RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS 550
AL+ + L K+ E + +LK+++E L+K+ S
Sbjct: 465 STQTVQALQYSTVDGPLTASKDLE------------------IKNLKEEIEKLRKQVTES 506
Query: 551 QISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLE 610
+ L++QL+E NA +R E D A R K KQI+ L+ DL
Sbjct: 507 -------SHLEQQLEEANA-VRQELDDAFRQIKAY---EKQIKTLQQEREDLN------- 548
Query: 611 TAKLKLEKEFINLQSALESERRDRT--HGSEIINDLQG----------RICGLEEDLKNG 658
KL++ E + +++ + + R+++ + ++ N+L+G +C +E +
Sbjct: 549 --KLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEIT 606
Query: 659 KILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADK 718
K+ K +LEK+ + E+E S E ++K +++ L E + A
Sbjct: 607 KL---KTDLEKKSI-----FYEEELSKREGIHANEIKNLKKELHDSEGQQLA-------- 650
Query: 719 NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINEL 778
+ K+++ LK K+E E++ + + KQ +
Sbjct: 651 -----------------LNKEIM---ILKDKLEKTRRESQSEREEFESEFKQQYE----- 685
Query: 779 LKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMK 838
++K +L E+ + LT ++L T L + +QL++E L + K
Sbjct: 686 -REKVLLTEENKKLT--------------SELDKLTTLYENLSIHNQQLEEEVKDLADKK 730
Query: 839 MNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQ 898
++ A++ + ++ + D+ +A Y L EL E + LG
Sbjct: 731 ESVAHWEAQITE-------IIQWVSDEKDARGYLQALASKMTEEL--EALRNSSLGTRAT 781
Query: 899 QKKQELQD-ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARH 957
+++ + ++A+LE+ + D+E A+ +E+ + ++ I+ E ++K+ ++
Sbjct: 782 DMPWKMRRFAKLDMSARLELQ-SALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKN 840
Query: 958 KQELTEKDATIASLEE 973
+ L+E + I EE
Sbjct: 841 LELLSEIEQLIKDTEE 856
Score = 80.1 bits (196), Expect = 1e-14
Identities = 99/441 (22%), Positives = 194/441 (43%), Gaps = 74/441 (16%)
Query: 725 IEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDV 784
+E+ K E +++++ + L+ + L A K D ++K +++I +L KQ
Sbjct: 451 LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASK-----DLEIKNLKEEIEKLRKQVTE 505
Query: 785 LNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQ 844
+ +EQ+ ++ + +L +Q+ + K L+QE L +++++ E
Sbjct: 506 SSH--------LEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKLEVHTEAL 557
Query: 845 NAEL---RKERQDADGQMKELQDQLEAEQYFSTLY---------KTQVRELKEECEEKT- 891
AE RK R+ ++ K+L+++LE + Y + ++ +LK + E+K+
Sbjct: 558 AAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSI 617
Query: 892 ----KLGK-------ELQQKKQELQD-ERDSLAAQLEITLTKADSEQLARSIAEEQYSDL 939
+L K E++ K+EL D E LA EI + K E+ R S
Sbjct: 618 FYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRE------SQS 671
Query: 940 EKEKIMKELEIKEMMARHKQELTEKDATIAS-----------LEETNRTLTSDVANLANE 988
E+E+ E E K+ R K LTE++ + S L N+ L +V +LA++
Sbjct: 672 EREEF--ESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK 729
Query: 989 KEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPV 1048
KE + + + E + + DE+ + ++A K L+ ++ A M K
Sbjct: 730 KESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWK--- 786
Query: 1049 KRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQA-------QIAEESQI 1101
+RR K + +EL+S + + Q+ELN+++A ++ + +
Sbjct: 787 -------MRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKK 839
Query: 1102 RIELQMTLDSKDSDIEQLRSQ 1122
+EL ++ D E+LRS+
Sbjct: 840 NLELLSEIEQLIKDTEELRSE 860
Score = 50.8 bits (120), Expect = 9e-06
Identities = 57/271 (21%), Positives = 130/271 (47%), Gaps = 25/271 (9%)
Query: 881 RELKEECEEKTKLGKELQQKKQELQ-------DERDSLAAQLEITLTKADSEQLARSIAE 933
R +K +EK +L ++LQ+ Q +Q D + + LEI K + E+L + + E
Sbjct: 446 RRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTE 505
Query: 934 EQYSDLEKEK---IMKELE--IKEMMARHKQ--ELTEKDATIASLEETNRTLTSDVANLA 986
+ + + E+ + +EL+ +++ A KQ L ++ + LE L ++ +
Sbjct: 506 SSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKLEVHTEALAAEASKDR 565
Query: 987 NEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNK---LAEIMN 1043
+E+ + K ++ +L LK ++IS + E Q + LKT K E ++
Sbjct: 566 KLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITK-LKTDLEKKSIFYEEELS 624
Query: 1044 RKEPVKRGNDTDVRRK----EKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEES 1099
++E + +++++ E + L+ E+ ++KL + + Q E E +++ ++
Sbjct: 625 KREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQY 684
Query: 1100 QIRIELQMTLDSK--DSDIEQLRSQLQALHI 1128
+ R ++ +T ++K S++++L + + L I
Sbjct: 685 E-REKVLLTEENKKLTSELDKLTTLYENLSI 714
Score = 40.0 bits (92), Expect = 0.016
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1154 EGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDI----DKLFHVR 1209
EG + +P KK GW + IV K+ YD + K ++ + D+ F V
Sbjct: 992 EGHVRIPKPAGVKK-GWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVS 1050
Query: 1210 PVTQTDVYRADAKEIPRIFQI 1230
V +DV A K+IP IF++
Sbjct: 1051 SVLASDVIHASRKDIPCIFRV 1071
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 436 bits (1120), Expect = e-121
Identities = 330/1195 (27%), Positives = 592/1195 (49%), Gaps = 115/1195 (9%)
Query: 27 QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQ 86
Q K + + SP++ E +LD L L + PAL K K++ NF+ +Y + +++ LQ
Sbjct: 32 QGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQ 91
Query: 87 MKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAF 146
A+D++V ++G G F EVQ+VR KA+ +YAMK++ K ++ + +FF EER+I++
Sbjct: 92 PSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSR 151
Query: 147 ANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDA 204
+ SPW+ QL YAFQD +LY+VMEY PGGDL++L++ Y+ + E +FY AE++LA+ +
Sbjct: 152 STSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHS 211
Query: 205 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 264
+H MG +HRD+KP+N+L+D+ GH+KL DFG+ KM+ MV+ +GTPDY++PEVL
Sbjct: 212 VHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTV 271
Query: 265 QGGD--GFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEIS 322
GD G YG +CDWWSVGV YEM+ G +PF + T++ IM+ + L FP+D ++S
Sbjct: 272 MNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVS 331
Query: 323 KHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSS 382
+LI + L ++ RL G + HPFF + W+NIR + P VP L SD D+S
Sbjct: 332 SDFLDLIQSLLCGQKERLKFEG---LCCHPFF--SKIDWNNIRNSPPPFVPTLKSDDDTS 386
Query: 383 NFDDIEDDKGDVETFPI---PKAFVGNQLPFIGFTYY-------RENLLLSDSPSCRETD 432
NFD+ E + V + P P F G +LPF+GF+Y R ++S S +T
Sbjct: 387 NFDEPEKNSW-VSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTS 445
Query: 433 SIQSR---KNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEIT 489
S++ + K++E Q+ Q K + +E+ ++ L ++ V L + EL+ T
Sbjct: 446 SMEKKLLIKSKELQDSQDKCHKMEQEMT-------RLHRRVSEVEAVLSQKEVELKASET 498
Query: 490 LRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQN 549
R +E L E + L+ + + + E DK L +D+ +L+++K++
Sbjct: 499 QRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQ 558
Query: 550 SQISTEKVNQLQRQLDETNALLRTESD-----------TAARLRKTQAESSKQIQQLESN 598
+Q+ E++ + QL+E R SD A ++ E ++ + +
Sbjct: 559 AQV--EEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQ 616
Query: 599 NRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDL--- 655
+ + LE + + + LQ LE + T +E++ +++ E +L
Sbjct: 617 GKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKL 676
Query: 656 ---KNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQE-EAEHKAT 711
++ + K +E +L+E+ + + ++E+ LK +Q E++ +
Sbjct: 677 QNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEV----HLKQKEQHYEEKIKVLDNQI 732
Query: 712 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLK-- 769
K LADK + E++ + E E K L E++ + +++ + E+R L K
Sbjct: 733 KKDLADKETL-ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLA 791
Query: 770 -QSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEK-QL 827
S +K ++ + ++R +E + K L+ Q ++++ S+K +L
Sbjct: 792 ANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRL 851
Query: 828 KQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEEC 887
+ L E+ + E+Q EL+++ + ++E + QL A Q ++Q+R+ K E
Sbjct: 852 LELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 911
Query: 888 EEKTKLGKE----LQQKKQELQDERDSLAAQLEI---------TLTKADSE------QLA 928
EE T +E L + E+Q + D+L + LT+ ++E L+
Sbjct: 912 EETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLS 971
Query: 929 RSIAEEQYSDLEKEKIMKELE-IKEMMARHKQELTEKDATIASLEETNRTLTSDVANLAN 987
+ + E ++ E ++ E++ ++ + + +LT + T+ +L+ T L V +L
Sbjct: 972 KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEA 1031
Query: 988 EKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKL--------- 1038
+EL K + + S L DE+ + ++ L TE+ + +A ++
Sbjct: 1032 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 1091
Query: 1039 ------AEIMNRKEPVK-----------RGNDTDVRRK--EKENRKLHMELKSEREKLTQ 1079
AEI+ ++ +K + ND + + E R L +L++ERE L Q
Sbjct: 1092 AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE-LKQ 1150
Query: 1080 QMIKYQKEL-NEMQAQIAEESQIRIELQMTLDSKD------SDIEQLRSQLQALH 1127
++++ Q +L +M Q ++ LQ LD D SD+E +Q L+
Sbjct: 1151 RLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLY 1205
Score = 102 bits (253), Expect = 3e-21
Identities = 182/871 (20%), Positives = 354/871 (40%), Gaps = 133/871 (15%)
Query: 418 ENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRL 477
+N+ + + RE + +Q+R+ + S+ I+KKL EE +A+ + + L
Sbjct: 660 QNIRQAKERAERELEKLQNRE-DSSEGIRKKLVEAEELEEKHREAQVSAQH----LEVHL 714
Query: 478 EKTAKELEEEI-TLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKK---RNLENDV 533
++ + EE+I L ++ L E + ++Q E K +++K +++ +
Sbjct: 715 KQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 774
Query: 534 NSLKDQLEDLKKRNQ---NSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSK 590
SL+ ++ +L + N+ NS + T++ + Q ++ + L + + + K +A++ K
Sbjct: 775 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM--ISELRQQKFYLETQAGKLEAQNRK 832
Query: 591 QIQQLES-NNRDLQDKNCLLETA-------------KLKLEKEFINLQSALESERRDRTH 636
+QLE +++D DKN LLE KL+L+++ LQ +L+ T
Sbjct: 833 LEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTA 892
Query: 637 GSEIINDLQGRICGLEEDLKNGKILLAKVELE-----------KRQLQERFTDLEKEKSN 685
LQ LE L+ K L + E + ++Q +F D +
Sbjct: 893 -------LQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKF-DALRNSCT 944
Query: 686 MEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERT 745
+ D+ QL + + + ++ +L + + + I + +SE + ++ + ER
Sbjct: 945 VITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEV--DHLRREITERE 1002
Query: 746 LKQKVENLLLEAEKR-CSLLDCDLKQSQQKINELLKQ-------KDVLNED-------VR 790
++ + +EA K C++L+ + + +ELL++ + VL ++ VR
Sbjct: 1003 MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVR 1062
Query: 791 NLTLKIEQETQKRCLTQNDLKMQTQQVN-TLKMSEKQLKQENNHLMEMKMNLEKQNA--- 846
L ++ E Q R + Q V +K + ++ L E K+ E +
Sbjct: 1063 ELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 1122
Query: 847 ELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEEC-EEKTKLGKELQQKKQELQ 905
+L K+ + + LQ +LE E RELK+ EE+ KL +++ +K +
Sbjct: 1123 DLEKKHAMLEMNARSLQQKLETE-----------RELKQRLLEEQAKLQQQMDLQKNHIF 1171
Query: 906 DERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE----KEKIMKELEIKE-------MM 954
L L+ L +AD + RS E Q +++ EK+ E I + +
Sbjct: 1172 ----RLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQ 1227
Query: 955 ARHKQELTEKDATIASLEE-----TNRTLTSDVANLANEKE-----ELNNKLKDVQEQLS 1004
A+ Q +K + +E T L + LA EKE EL L+ + +L
Sbjct: 1228 AKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELR 1287
Query: 1005 RLKDEEISAAAIKAQFEKQLLTERTLKTQ---------------AVNKLAEIMNRKEPVK 1049
++E AA KA T T + Q A++ LA +R++
Sbjct: 1288 SAREE---AAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESS 1344
Query: 1050 RGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTL 1109
+ R KE+ + + L + K L+ + ++ +E Q+
Sbjct: 1345 TPEEFSRRLKERMHHNIPHRFNVG---LNMRATKCAVCLDTVH--FGRQASKCLECQVMC 1399
Query: 1110 DSKDSDIEQLRSQLQALHIGLDSSSIG----SGPGDAEADDGFPESRLEGWLSLPVRNNT 1165
K S L A + + + + PG + + LEGW+ +P N
Sbjct: 1400 HPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPG-LQTKEPSSSLHLEGWMKVPRNNKR 1458
Query: 1166 KKFGWVKKYVIVSSKKILFYDSEQDKEQSNP 1196
+ GW +KY+++ K+L YD+E + P
Sbjct: 1459 GQQGWDRKYIVLEGSKVLIYDNEAREAGQRP 1489
Score = 77.0 bits (188), Expect = 1e-13
Identities = 95/491 (19%), Positives = 217/491 (44%), Gaps = 59/491 (12%)
Query: 695 KVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLL 754
K++ +S E ++++ K K + +++ + E ++ + + E +L T + +E L
Sbjct: 450 KLLIKSKELQDSQDKCHKME-QEMTRLHRRVSEVEA-VLSQKEVELKASETQRSLLEQDL 507
Query: 755 LEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ-NDLKMQ 813
CS L L+Q++ ++++ + L D+R + K+++ ++ Q ++++
Sbjct: 508 ATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLM 567
Query: 814 TQQVNTLKMS--------EKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQ-- 863
Q+ +S E +L++ E K + +L K + ++ E
Sbjct: 568 MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKL 627
Query: 864 DQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKAD 923
+++ AEQ + +++EL+E+ E+ K E + Q ++ ++ +LE + D
Sbjct: 628 EKINAEQ------QLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRED 681
Query: 924 S-----------EQLARSIAEEQYSDLEKEKIMKELE------IKEMMARHKQELTEKDA 966
S E+L E Q S E +K+ E IK + + K++L +K+
Sbjct: 682 SSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE- 740
Query: 967 TIASLEETNRTLTSDVANLANEKEELNN----KLKDVQEQLSRLKDEEISAAAIKAQFEK 1022
T+ ++ + + + + +E++ + N K++ +++++ L + AA
Sbjct: 741 TLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAA------NS 794
Query: 1023 QLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELK-------SERE 1075
L T+R +K Q E+++ K +T + E +NRKL +L+ S++
Sbjct: 795 SLFTQRNMKAQE-----EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKN 849
Query: 1076 KLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSI 1135
+L + + ++ E + Q E + ELQ++L ++S + L++ AL L +
Sbjct: 850 RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909
Query: 1136 GSGPGDAEADD 1146
AEA++
Sbjct: 910 ELEETTAEAEE 920
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 419 bits (1076), Expect = e-116
Identities = 272/818 (33%), Positives = 451/818 (55%), Gaps = 91/818 (11%)
Query: 26 RQRKLEALIRDPRSPI-NVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRG 84
R R LE L R ++ LLD L +L +L LR+ +++ FL+ V K++
Sbjct: 4 RLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKE 63
Query: 85 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 144
L+++ +D++++KVIGRGAFGEV +VR + + +++AMK+L K+EM+KR+++A F EERD++
Sbjct: 64 LRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVL 123
Query: 145 AFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLAL 202
+S WV L YAFQD+ YLY+VM+Y GGDL+ L+S ++ +P + A+FY AE+VLA+
Sbjct: 124 VKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAI 183
Query: 203 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 262
++H +G +HRDVKPDN+LLD +GH++LADFG+C++++ GMV AVGTPDYISPE+L
Sbjct: 184 HSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEIL 243
Query: 263 KS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDA-E 320
++ + G G YG +CDWWS+GV YE+L G+TPFYA+SLV TY KIM+H++ L FP D +
Sbjct: 244 QAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPD 303
Query: 321 ISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDID 380
+ A++LI L +E RLGR G+++ R HPFF+ W+ + + AP +PEL +D
Sbjct: 304 VPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVD--WERLASSTAPYIPELRGPMD 361
Query: 381 SSNFDDIEDDKGDVETFPIPK--AFVGNQLPFIGFTYYREN----------LLLSDSPSC 428
+SNFD +D T P P AF G+ LPF+GFTY + L C
Sbjct: 362 TSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQC 421
Query: 429 RETDSIQ-SRKNEES----------QEIQKKLYTLEEHLSNEMQAKEELEQ--------- 468
E + ++ SRK++E+ ++++K++ TL + L ++ K L Q
Sbjct: 422 LEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSP 481
Query: 469 -KCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKR 527
+ + L++ +EL E + L+ E+E Q + E ++ +++
Sbjct: 482 GQDSDLRQELDRLHRELAEG-------RAGLQAQEQELCRAQGQQEELLQRLQEAQEREA 534
Query: 528 NLENDVNSLKDQLEDLK--KRNQNSQIS--TEKVNQLQRQ----LDETN--ALLRTESDT 577
+ +L QLE+ + +R +Q+S + +V QLQ Q L+E++ + T S+T
Sbjct: 535 ATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASET 594
Query: 578 -----------AARLRKTQAESSKQIQQLESNN-RDLQDKNCLL--ETAKLKLEKEFINL 623
A+LRK A +Q++Q S+ ++ C L E +L E+E +
Sbjct: 595 NGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEA 654
Query: 624 QSALESERRDRTHGS--EIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEK 681
+ A E E + R G E ++ + ++ + + + K+ + LQ T + +
Sbjct: 655 ELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKV-------SRGYLQALATKMAE 707
Query: 682 EKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARL----ADKNKIYESIEEAKSEAMKEME 737
E ++ V Q+L +H+ RL A +S EA+ A + ++
Sbjct: 708 ELESLR-------NVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQ 760
Query: 738 KKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKI 775
++L + + + + E L EAEK+ L +L ++++
Sbjct: 761 ERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798
Score = 64.7 bits (156), Expect = 6e-10
Identities = 93/425 (21%), Positives = 172/425 (40%), Gaps = 56/425 (13%)
Query: 727 EAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLN 786
E+ SEA +E+KL + ++KVE L + D ++ +Q E+ +D L
Sbjct: 406 ESSSEAWAALERKL--QCLEQEKVE--LSRKHQEALHAPTDHRELEQLRKEVQTLRDRLP 461
Query: 787 EDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNA 846
E +R+ K L+Q D + + +L + + L E + L+ Q
Sbjct: 462 EMLRD----------KASLSQTDGPPAGSPGQDSDLRQ-ELDRLHRELAEGRAGLQAQEQ 510
Query: 847 ELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQD 906
EL + A GQ +EL +L+ Q +Q R L + EE +EL+ + L
Sbjct: 511 ELCR----AQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSR 566
Query: 907 ERDSLAAQLEITLTKADSEQLARSIAE----------EQYSDLEKEKIMKELEIKEMMAR 956
+ L Q E L ++ + + +E Q + L KE ++++
Sbjct: 567 QVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQ---A 623
Query: 957 HKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE------- 1009
H + K+ + L+E NR L+ E+E L +L QE RL+ E
Sbjct: 624 HSHRPSGKEEALCQLQEENR-------RLSREQERLEAELAQEQESKQRLEGERRETESN 676
Query: 1010 -EISAAAIKAQFEKQLLTE---RTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRK 1065
E A I + + ++ + L T+ +L + N D + K + +K
Sbjct: 677 WEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQK 736
Query: 1066 LHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDS-----DIEQLR 1120
+ + E + + I+ ++ L E Q+ +E+Q++ E ++ K S ++ LR
Sbjct: 737 MEASARLELQSALEAEIRAKQGLQERLTQV-QEAQLQAERRLQEAEKQSQALQQELAMLR 795
Query: 1121 SQLQA 1125
+L+A
Sbjct: 796 EELRA 800
Score = 45.1 bits (105), Expect = 5e-04
Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 7/82 (8%)
Query: 1154 EGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNP----YMVLDI-DKLFHV 1208
EG+LS+P + ++ GW + + +S ++L +D+ D S P VLD+ D F
Sbjct: 951 EGFLSVPRPSGVRR-GWQRVFAALSDSRLLLFDAP-DLRLSPPSGALLQVLDLRDPQFSA 1008
Query: 1209 RPVTQTDVYRADAKEIPRIFQI 1230
PV +DV A ++++PRIF++
Sbjct: 1009 TPVLASDVIHAQSRDLPRIFRV 1030
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 365 bits (937), Expect = e-100
Identities = 202/525 (38%), Positives = 310/525 (59%), Gaps = 40/525 (7%)
Query: 26 RQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGL 85
R R+L+ L+ DP + +E LLD L + +L L ++K + +FL E IV +++ +
Sbjct: 6 RLRRLQQLVLDPGF-LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEV 64
Query: 86 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 145
+++ +D++++KVIGRGAF EV +V+ K + +VYAMK+++K++M+KR + + F EERD++
Sbjct: 65 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 124
Query: 146 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALD 203
+ W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + A+FY AE+V+A+D
Sbjct: 125 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 184
Query: 204 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 263
++H +G +HRD+KPDN+LLD+ GH++LADFG+C+K+ G V AVGTPDY+SPE+L+
Sbjct: 185 SVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ 244
Query: 264 SQG---GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFP-EDA 319
+ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+ +K L P D
Sbjct: 245 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDE 304
Query: 320 EISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDI 379
+ + A++ I L E RLGR G + R HPFF WD +R++ P P+
Sbjct: 305 GVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDFEGAT 362
Query: 380 DSSNFDDIEDDKGDVETFPIPK--AFVGNQLPFIGFTY------------------YREN 419
D+ NFD +ED +ET + A +G LPF+G++Y E
Sbjct: 363 DTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQ 422
Query: 420 LLLS--DSPSCRETDSIQSRKNE---------ESQEIQKKLYTLEEHLSNEMQAKEELEQ 468
LL +PS + S Q E E + L L+E L E+ ++ L +
Sbjct: 423 LLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSR 482
Query: 469 KCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA 513
+ +++ T + A +L E + +E+ +RQL+ LLQ + A
Sbjct: 483 EMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGA 527
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 365 bits (937), Expect = e-100
Identities = 202/525 (38%), Positives = 310/525 (59%), Gaps = 40/525 (7%)
Query: 26 RQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGL 85
R R+L+ L+ DP + +E LLD L + +L L ++K + +FL E IV +++ +
Sbjct: 6 RLRRLQQLVLDPGF-LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEV 64
Query: 86 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 145
+++ +D++++KVIGRGAF EV +V+ K + +VYAMK+++K++M+KR + + F EERD++
Sbjct: 65 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 124
Query: 146 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALD 203
+ W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + A+FY AE+V+A+D
Sbjct: 125 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 184
Query: 204 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 263
++H +G +HRD+KPDN+LLD+ GH++LADFG+C+K+ G V AVGTPDY+SPE+L+
Sbjct: 185 SVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ 244
Query: 264 SQG---GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFP-EDA 319
+ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+ +K L P D
Sbjct: 245 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDE 304
Query: 320 EISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDI 379
+ + A++ I L E RLGR G + R HPFF WD +R++ P P+
Sbjct: 305 GVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDFEGAT 362
Query: 380 DSSNFDDIEDDKGDVETFPIPK--AFVGNQLPFIGFTY------------------YREN 419
D+ NFD +ED +ET + A +G LPF+G++Y E
Sbjct: 363 DTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQ 422
Query: 420 LLLS--DSPSCRETDSIQSRKNE---------ESQEIQKKLYTLEEHLSNEMQAKEELEQ 468
LL +PS + S Q E E + L L+E L E+ ++ L +
Sbjct: 423 LLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSR 482
Query: 469 KCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA 513
+ +++ T + A +L E + +E+ +RQL+ LLQ + A
Sbjct: 483 EMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGA 527
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 362 bits (928), Expect = 2e-99
Identities = 203/530 (38%), Positives = 310/530 (58%), Gaps = 45/530 (8%)
Query: 26 RQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGL 85
R R+L+ L+ DP + +E LLD L + +L L ++K + +FL E IV +++ +
Sbjct: 6 RLRRLQQLVLDPGF-LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEV 64
Query: 86 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 145
+++ +D++++KVIGRGAF EV +V+ K + +VYAMK+++K++M+KR + + F EERD++
Sbjct: 65 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 124
Query: 146 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALD 203
+ W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + A+FY AE+V+A+D
Sbjct: 125 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 184
Query: 204 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 263
++H +G +HRD+KPDN+LLD+ GH++LADFG+C+K+ G V AVGTPDY+SPE+L+
Sbjct: 185 SVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ 244
Query: 264 SQG---GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFP-EDA 319
+ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+ +K L P D
Sbjct: 245 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDE 304
Query: 320 EISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDI 379
+ + A++ I L E RLGR G + R HPFF WD +R++ P P+
Sbjct: 305 GVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDFEGAT 362
Query: 380 DSSNFDDIEDD-----KGDVETFPIPK--AFVGNQLPFIGFTY----------------- 415
D+ NFD +ED G ET + A +G LPF+G++Y
Sbjct: 363 DTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPME 422
Query: 416 -YRENLLLS--DSPSCRETDSIQSRKNE---------ESQEIQKKLYTLEEHLSNEMQAK 463
E LL +PS + S Q E E + L L+E L E+ +
Sbjct: 423 LEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTR 482
Query: 464 EELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA 513
+ L ++ +++ T + A +L E + +E+ +RQL+ LLQ + A
Sbjct: 483 QSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGA 532
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 343 bits (881), Expect = 5e-94
Identities = 187/480 (38%), Positives = 283/480 (58%), Gaps = 44/480 (9%)
Query: 76 EKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSA 135
E IV +++ ++++ +D++++KVIGRGAF EV +V+ K + +VYAMK+++K++M+KR + +
Sbjct: 65 EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 124
Query: 136 FFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKF 193
F EERD++ + W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + A+F
Sbjct: 125 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 184
Query: 194 YTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGT 253
Y AE+V+A+D++H +G +HRD+KPDN+LLD+ GH++LADFG+C+K+ G V AVGT
Sbjct: 185 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 244
Query: 254 PDYISPEVLKSQG---GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHK 310
PDY+SPE+L++ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+ +K
Sbjct: 245 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 304
Query: 311 NSLCFP-EDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAA 369
L P D + + A++ I L E RLGR G + R HPFF WD +R++
Sbjct: 305 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVP 362
Query: 370 PVVPELSSDIDSSNFDDIEDD-----KGDVETFPIPK--AFVGNQLPFIGFTY------- 415
P P+ D+ NFD +ED G ET + A +G LPF+G++Y
Sbjct: 363 PFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRD 422
Query: 416 -----------YRENLLLS--DSPSCRETDSIQSRKNE---------ESQEIQKKLYTLE 453
E LL +PS + S Q E E + L L+
Sbjct: 423 SEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQ 482
Query: 454 EHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA 513
E L E+ ++ L ++ +++ T + A +L E + +E+ +RQL+ LLQ + A
Sbjct: 483 EALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGA 542
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 226 bits (575), Expect = 2e-58
Identities = 133/392 (33%), Positives = 216/392 (55%), Gaps = 19/392 (4%)
Query: 3 RPPPTGKMPGAPETAPGDGAGASR--QRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP 60
R PP + G ASR R + D ++ + +SL ++ + D
Sbjct: 5 REPPCNQYTGTTTALQKLEGFASRLFHRHSKGTAHDQKTALENDSLHFSEHTALWDRSMK 64
Query: 61 A-LRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYA 119
L K K ++FL ++E + GL ED++ K +G G+FG V LV+HKA+++ YA
Sbjct: 65 EFLAKAK--EDFLKKWENPTQNNAGL----EDFERKKTLGTGSFGRVMLVKHKATEQYYA 118
Query: 120 MKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN 179
MK+L K +++K E+ I+ N P++V+L YAF+D+ LYMVMEY+PGG++ +
Sbjct: 119 MKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFS 178
Query: 180 LMSNYD-VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMK 238
+ E A+FY A++VL + +HS+ LI+RD+KP+N+L+D G++++ DFG +
Sbjct: 179 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR 238
Query: 239 MDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADS 298
+ C GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD
Sbjct: 239 VKGRTWTLC----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQ 290
Query: 299 LVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQ 358
+ Y KI+ K +++ +NL+ LT R L +NGV +I+ H +F
Sbjct: 291 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVSDIKTHKWFATTD 349
Query: 359 WHWDNIRETAAPVVPELSSDIDSSNFDDIEDD 390
W R+ AP +P+ D+SNFDD E++
Sbjct: 350 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEE 381
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 224 bits (572), Expect = 3e-58
Identities = 118/323 (36%), Positives = 192/323 (59%), Gaps = 14/323 (4%)
Query: 69 DNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEM 128
++FL ++E + GL ED++ K +G G+FG V LV+HKA+++ YAMK+L K ++
Sbjct: 25 EDFLKKWENPTQNNAGL----EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKV 80
Query: 129 IKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VP 187
+K E+ I+ N P++V+L YAF+D+ LYMVMEY+PGG++ + +
Sbjct: 81 VKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140
Query: 188 EKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHC 247
E A+FY A++VL + +HS+ LI+RD+KP+N+L+D G++++ DFG ++ C
Sbjct: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLC 200
Query: 248 DTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 307
GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y KI+
Sbjct: 201 ----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
Query: 308 DHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRET 367
K +++ +NL+ LT R L +NGV +I+ H +F W R+
Sbjct: 253 SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVSDIKTHKWFATTDWIAIYQRKV 311
Query: 368 AAPVVPELSSDIDSSNFDDIEDD 390
AP +P+ D+SNFDD E++
Sbjct: 312 EAPFIPKFRGSGDTSNFDDYEEE 334
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 221 bits (562), Expect = 5e-57
Identities = 111/316 (35%), Positives = 194/316 (61%), Gaps = 17/316 (5%)
Query: 90 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 149
+D+D + +G G FG V LV+ K ++ +A+K++S ++I+ E+ ++ +
Sbjct: 47 QDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSH 106
Query: 150 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHSM 208
P++++LF+ + D+R+LYM+MEY+PGG+L + + N FY+AE++ A++ +HS
Sbjct: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
Query: 209 GLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGD 268
+++RD+KP+N+LLD+ GH+KL DFG K+ + C GTP+Y++PEV++S+G
Sbjct: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLC----GTPEYLAPEVIQSKG-- 220
Query: 269 GFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNL 328
+GR DWW++G+ ++EML G PF+ D+ G Y KI+ K + FP + H K+L
Sbjct: 221 --HGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGK--IDFPRHLDF--HVKDL 274
Query: 329 ICAFL-TDREVRLG--RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFD 385
I L DR RLG +NG +++ H +F++ W R+ P+VP+++ D D+SNF+
Sbjct: 275 IKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
Query: 386 DIEDDKGDVETFPIPK 401
++ D P+P+
Sbjct: 335 TYPENDWDTAA-PVPQ 349
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 219 bits (558), Expect = 1e-56
Identities = 123/328 (37%), Positives = 192/328 (58%), Gaps = 33/328 (10%)
Query: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 150
D+D +K+I GA+G V LVRH+ +++ +AMK ++K +I R+ + ERDI+ FA +P
Sbjct: 373 DFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 432
Query: 151 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHSMG 209
+VV +F +F+ R+L MVMEY+ GGD L+ N +P + A+ Y AE VLAL+ +H+ G
Sbjct: 433 FVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYG 492
Query: 210 LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT------------------AV 251
++HRD+KPDN+L+ GH+KL DFG + + G++ T
Sbjct: 493 IVHRDLKPDNLLITSMGHIKLTDFG----LSKMGLMSLTTNLYEGHIEKDAREFLDKQVC 548
Query: 252 GTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKN 311
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + +++ +
Sbjct: 549 GTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--SD 602
Query: 312 SLCFPE-DAEISKHAKNLICAFL-TDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAA 369
+ +PE D + A+ LI + L T+ VRLG G E++QH FF++ W + A
Sbjct: 603 DILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRD--LDWTGLLRQKA 660
Query: 370 PVVPELSSDIDSSNFDDIEDDKGDVETF 397
+P L S+ D+S FD D V ++
Sbjct: 661 EFIPHLESEDDTSYFDTRSDRYHHVNSY 688
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 216 bits (551), Expect = 9e-56
Identities = 121/330 (36%), Positives = 191/330 (57%), Gaps = 33/330 (10%)
Query: 88 KAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 147
+ D++ +K+I GA+G V VRHK S++ +AMK ++K +I R+ + ERDI+ FA
Sbjct: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
Query: 148 NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDAIH 206
+P+VV ++ +F+ R+L MVMEY+ GGD LM N +P A+ Y AE VLAL+ +H
Sbjct: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLH 496
Query: 207 SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT----------------- 249
+ G++HRD+KPDN+L+ GH+KL DFG + + G++ T
Sbjct: 497 NYGIVHRDLKPDNLLVTSMGHIKLTDFG----LSKVGLMSMTTNLYEGHIEKDAREFLDK 552
Query: 250 -AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMD 308
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + +++
Sbjct: 553 QVCGTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI- 607
Query: 309 HKNSLCFPE-DAEISKHAKNLICAFLTDREV-RLGRNGVEEIRQHPFFKNDQWHWDNIRE 366
+ + +PE D A++LI L + RLG G E++QH FF++ W+++
Sbjct: 608 -SDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRS--LDWNSLLR 664
Query: 367 TAAPVVPELSSDIDSSNFDDIEDDKGDVET 396
A +P+L S+ D+S FD + +ET
Sbjct: 665 QKAEFIPQLESEDDTSYFDTRSEKYHHMET 694
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 216 bits (550), Expect = 1e-55
Identities = 114/307 (37%), Positives = 191/307 (62%), Gaps = 16/307 (5%)
Query: 89 AEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 148
++ ++ ++ +G G+FG V LVRH+ + YAMK+L+K +++K E+ I+ +
Sbjct: 41 SDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAID 100
Query: 149 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHS 207
P++V+L ++F+D+ YLY+VMEY+PGG++ + + E A FY A+VVLA+ +HS
Sbjct: 101 FPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHS 160
Query: 208 MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGG 267
+ LIHRD+KP+N+L+D+ G+L++ DFG ++ C GTP+Y++PE++ S+G
Sbjct: 161 LDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLC----GTPEYLAPEIILSKG- 215
Query: 268 DGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKN 327
Y + DWW++GV +YEM VG PFYAD + Y KI+ + + FP +++S K+
Sbjct: 216 ---YNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGR--VRFP--SKLSSDLKH 268
Query: 328 LICAFL-TDREVRLG--RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNF 384
L+ + L D R G RNGV +I+ H +F W ++ AP +P+ + D+SNF
Sbjct: 269 LLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNF 328
Query: 385 DDIEDDK 391
DD E+++
Sbjct: 329 DDYEEEE 335
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 215 bits (547), Expect = 3e-55
Identities = 112/324 (34%), Positives = 190/324 (58%), Gaps = 14/324 (4%)
Query: 69 DNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEM 128
++FL ++E + L + ++ +K +G G+FG V LV+HK + YAMK+L K ++
Sbjct: 17 EDFLKKWESPAQNTAHL----DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKV 72
Query: 129 IKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VP 187
+K E+ I+ N P++V+L ++F+D+ LYMVMEY+PGG++ + +
Sbjct: 73 VKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 132
Query: 188 EKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHC 247
E A+FY A++VL + +HS+ LI+RD+KP+N+L+D+ G++++ DFG ++ C
Sbjct: 133 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC 192
Query: 248 DTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 307
GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y KI+
Sbjct: 193 ----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 244
Query: 308 DHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRET 367
K +++ +NL+ LT R L +NGV +I+ H +F W R+
Sbjct: 245 SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVNDIKNHKWFATTDWIAIYQRKV 303
Query: 368 AAPVVPELSSDIDSSNFDDIEDDK 391
AP +P+ D+SNFDD E+++
Sbjct: 304 EAPFIPKFKGPGDTSNFDDYEEEE 327
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 215 bits (547), Expect = 3e-55
Identities = 112/324 (34%), Positives = 190/324 (58%), Gaps = 14/324 (4%)
Query: 69 DNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEM 128
++FL ++E + L + ++ +K +G G+FG V LV+HK + YAMK+L K ++
Sbjct: 25 EDFLKKWESPAQNTAHL----DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKV 80
Query: 129 IKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VP 187
+K E+ I+ N P++V+L ++F+D+ LYMVMEY+PGG++ + +
Sbjct: 81 VKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140
Query: 188 EKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHC 247
E A+FY A++VL + +HS+ LI+RD+KP+N+L+D+ G++++ DFG ++ C
Sbjct: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC 200
Query: 248 DTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 307
GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y KI+
Sbjct: 201 ----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
Query: 308 DHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRET 367
K +++ +NL+ LT R L +NGV +I+ H +F W R+
Sbjct: 253 SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVNDIKNHKWFATTDWIAIYQRKV 311
Query: 368 AAPVVPELSSDIDSSNFDDIEDDK 391
AP +P+ D+SNFDD E+++
Sbjct: 312 EAPFIPKFKGPGDTSNFDDYEEEE 335
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 214 bits (545), Expect = 5e-55
Identities = 118/317 (37%), Positives = 183/317 (57%), Gaps = 33/317 (10%)
Query: 90 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 149
ED++ +K+I GA+G V LVRHK++++ +AMK ++K +I R+ + ERDI+ FA +
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
Query: 150 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHSM 208
P+VV +F +F R+L MVMEY+ GGD L+ N +P + Y AE VLAL+ +H+
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 629
Query: 209 GLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT------------------A 250
G++HRD+KPDN+L+ GH+KL DFG + + G++ T
Sbjct: 630 GIVHRDLKPDNLLITSMGHIKLTDFG----LSKIGLMSLTTNLYEGHIEKDAREFLDKQV 685
Query: 251 VGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHK 310
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + +++
Sbjct: 686 CGTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 739
Query: 311 NSLCFPE-DAEISKHAKNLICAFLTDREV-RLGRNGVEEIRQHPFFKNDQWHWDNIRETA 368
+ + +PE D + A++L L + RLG E++QHPFF W +
Sbjct: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTG--LDWTGLLRQK 797
Query: 369 APVVPELSSDIDSSNFD 385
A +P+L S+ D+S FD
Sbjct: 798 AEFIPQLESEDDTSYFD 814
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 213 bits (542), Expect = 1e-54
Identities = 119/316 (37%), Positives = 185/316 (58%), Gaps = 33/316 (10%)
Query: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 150
D++ +K+I GA+G V LVRH+ +++ +A+K ++K +I R+ + ERDI+ FA +P
Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
Query: 151 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDAIHSMG 209
+VV +F +F+ R+L MVMEY+ GGD L+ N +P A+ Y AE VLAL+ +H+ G
Sbjct: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYG 485
Query: 210 LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT------------------AV 251
++HRD+KPDN+L+ GH+KL DFG + + G++ T
Sbjct: 486 IVHRDLKPDNLLITSLGHIKLTDFG----LSKIGLMSMATNLYEGHIEKDAREFIDKQVC 541
Query: 252 GTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKN 311
GTP+YI+PEV+ QG YG+ DWW++GV LYE LVG PF+ D+ + +++ +
Sbjct: 542 GTPEYIAPEVIFRQG----YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVV--SD 595
Query: 312 SLCFPE-DAEISKHAKNLICAFLTDREV-RLGRNGVEEIRQHPFFKNDQWHWDNIRETAA 369
+ +PE D + A++LI L + RLG G E++QHPFF W + A
Sbjct: 596 EIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFL--ALDWAGLLRHKA 653
Query: 370 PVVPELSSDIDSSNFD 385
VP+L ++ D+S FD
Sbjct: 654 EFVPQLEAEDDTSYFD 669
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 206 bits (524), Expect = 1e-52
Identities = 129/352 (36%), Positives = 201/352 (57%), Gaps = 19/352 (5%)
Query: 79 VKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFW 138
V++ + ++ ++++ +KV+G+G+FG+V L K +VYA+K+L K +++ D
Sbjct: 395 VRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTM 454
Query: 139 EERDIMAFANS-PWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVPEKWAKFYTA 196
E+ I+A A P++ QL+ FQ L+ VMEY+ GGDL+ + + E ++FY A
Sbjct: 455 TEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAA 514
Query: 197 EVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDY 256
EV AL +H G+I+RD+K DN+LLD GH KLADFG C + G V T GTPDY
Sbjct: 515 EVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNG-VTTTTFCGTPDY 573
Query: 257 ISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFP 316
I+PE+L+ YG DWW++GV +YEM+ G PF AD+ + I+ + + +P
Sbjct: 574 IAPEILQELE----YGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESIL--HDDVLYP 627
Query: 317 EDAEISKHAKNLICAFLT-DREVRLG----RNGVEEIRQHPFFKNDQWHWDNIRETAAPV 371
+SK A +++ AF+T + RLG +NG + I+QHPFFK W ++ P
Sbjct: 628 --VWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPF 685
Query: 372 VPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVG--NQLPFIGFTYYRENLL 421
P + + D +NFD + V T + +A V NQ F GF+Y+ E+L+
Sbjct: 686 KPRIKTKRDVNNFDQDFTREEPVLTL-VDEAIVKQINQEEFKGFSYFGEDLM 736
Score = 34.3 bits (77), Expect = 0.85
Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 11/125 (8%)
Query: 1240 KEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIK 1299
K+QE P + VG + + + H+F Y PT C+ C LW + + L+C+ C +
Sbjct: 224 KKQETP-DQVGSQ-RFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLR--QGLQCKVCKMN 279
Query: 1300 CHKDHMDKKEEIIAP-CKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPF 1358
H+ + E +AP C V D +L T ++ + KK+ +P P
Sbjct: 280 VHR----RCETNVAPNCGV--DARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPA 333
Query: 1359 ARSSP 1363
+ SSP
Sbjct: 334 SGSSP 338
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 200 bits (508), Expect = 9e-51
Identities = 116/304 (38%), Positives = 175/304 (57%), Gaps = 14/304 (4%)
Query: 85 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 144
+++K ED+ + K++G+G+FG+V L K + + +A+K L K ++ D E+ ++
Sbjct: 373 IKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVL 432
Query: 145 AFA-NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVPEKWAKFYTAEVVLAL 202
+ A P++ +F FQ L+ VMEY+ GGDL+ ++ S + A FY AE++L L
Sbjct: 433 SLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGL 492
Query: 203 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 262
+HS G+++RD+K DN+LLDK GH+K+ADFG C K + G +T GTPDYI+PE+L
Sbjct: 493 QFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMC-KENMLGDAKTNTFCGTPDYIAPEIL 551
Query: 263 KSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEIS 322
Q Y DWWS GV LYEML+G +PF+ + I ++ +P E
Sbjct: 552 LGQK----YNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI--RMDNPFYPRWLE-- 603
Query: 323 KHAKNLIC-AFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDS 381
K AK+L+ F+ + E RLG G +IRQHP F+ W +E P P++ S D
Sbjct: 604 KEAKDLLVKLFVREPEKRLGVRG--DIRQHPLFREINWEELERKEIDPPFRPKVKSPFDC 661
Query: 382 SNFD 385
SNFD
Sbjct: 662 SNFD 665
Score = 40.4 bits (93), Expect = 0.012
Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 1259 KGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPC 1315
K HEF T + PT C C + +W + K +CR+C+ HK +DK +IA C
Sbjct: 158 KCHEFTATFFPQPTFCSVCHEFVWGLNK--QGYQCRQCNAAIHKKCIDK---VIAKC 209
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 199 bits (507), Expect = 1e-50
Identities = 122/345 (35%), Positives = 187/345 (54%), Gaps = 17/345 (4%)
Query: 86 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 145
+MK D++ + V+G+G+FG+V L K + ++YA+K+L K +I+ D E+ ++A
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395
Query: 146 FANSP-WVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVPEKWAKFYTAEVVLALD 203
P ++ QL FQ LY VMEY+ GGDL+ ++ E A FY AE+ + L
Sbjct: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
Query: 204 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 263
+ S G+I+RD+K DN++LD GH+K+ADFG C + G V T GTPDYI+PE++
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTTKTFCGTPDYIAPEIIA 514
Query: 264 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISK 323
Q YG+ DWW+ GV LYEML G PF + + IM+H ++ +P+ +SK
Sbjct: 515 YQP----YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH--NVAYPK--SMSK 566
Query: 324 HAKNLICAFLT---DREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDID 380
A + +T + + G G +I++H FF+ W +E P P+ D
Sbjct: 567 EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRD 626
Query: 381 SSNFDDIEDDKGDVETFPIPKAFVGN--QLPFIGFTYYRENLLLS 423
+SNFD E + VE P K F+ N Q F GF+Y +++
Sbjct: 627 TSNFDK-EFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVIN 670
>gi|239752561 PREDICTED: similar to Rho-associated, coiled-coil
containing protein kinase 1 [Homo sapiens]
Length = 143
Score = 197 bits (500), Expect = 8e-50
Identities = 89/135 (65%), Positives = 112/135 (82%), Gaps = 5/135 (3%)
Query: 1246 VEPV--GEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKD 1303
+EPV EK+N+ HKGHEFIPTLYHFP NC+AC KPLWH+FKPPPALECRRCH+KCH+D
Sbjct: 1 MEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRD 60
Query: 1304 HMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSP 1363
H+DKKE++I PCKV YD+++A+++LLLA S +EQ+KWV+ LVKKIPK PP+ F R+SP
Sbjct: 61 HLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPS--GFVRASP 118
Query: 1364 RT-SMKIQQNQSIRR 1377
RT S + NQS R+
Sbjct: 119 RTLSTRSTANQSFRK 133
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 196 bits (497), Expect = 2e-49
Identities = 110/314 (35%), Positives = 188/314 (59%), Gaps = 17/314 (5%)
Query: 87 MKAEDYDVVKVIGRGAFGEVQLVRHKASQ-KVYAMKLLSKFEMIKRSDSAFFWEERDIMA 145
+K D++++ +G G FG V+LV+ K+ + K +AMK+L K ++ E+ IM
Sbjct: 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 414
Query: 146 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDA 204
A+S ++V+L+ F+D +YLYM+ME GG+L ++ + + +FYTA VV A
Sbjct: 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
Query: 205 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 264
+HS G+I+RD+KP+N++LD G+ KL DFG K+ T GTP+Y++PE++ +
Sbjct: 475 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW--TFCGTPEYVAPEIILN 532
Query: 265 QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKH 324
+G D D+WS+G+ +YE+L G PF + TY+ I+ + + FP+ +I+K+
Sbjct: 533 KGHD----ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPK--KIAKN 586
Query: 325 AKNLICAFLTDR-EVRLG--RNGVEEIRQHPFFKNDQWHWDNIRE--TAAPVVPELSSDI 379
A NLI D RLG +NGV++I++H +F+ ++W+ +R+ P++P ++S
Sbjct: 587 AANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEG--FNWEGLRKGTLTPPIIPSVASPT 644
Query: 380 DSSNFDDIEDDKGD 393
D+SNFD +D +
Sbjct: 645 DTSNFDSFPEDNDE 658
Score = 30.8 bits (68), Expect = 9.4
Identities = 33/153 (21%), Positives = 73/153 (47%), Gaps = 10/153 (6%)
Query: 931 IAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKE 990
+ EE+ +LEK KE EI+E+ K++L K ++ + T+ + A + +
Sbjct: 14 LKEERIKELEKRLSEKEEEIQEL----KRKL-HKCQSVLPVPSTHIGPRTTRAQGISAEP 68
Query: 991 ELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKR 1050
+ D+++ + E S IK + +L +K ++++ EI++ PV+
Sbjct: 69 QTYRSFHDLRQAFRKFTKSERSKDLIK----EAILDNDFMKNLELSQIQEIVDCMYPVEY 124
Query: 1051 GNDTDVRRKEKENRKLHMELKSEREKLTQQMIK 1083
G D+ + KE + L ++ + ++T++ +K
Sbjct: 125 GKDSCI-IKEGDVGSLVYVMEDGKVEVTKEGVK 156
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 196 bits (497), Expect = 2e-49
Identities = 110/314 (35%), Positives = 188/314 (59%), Gaps = 17/314 (5%)
Query: 87 MKAEDYDVVKVIGRGAFGEVQLVRHKASQ-KVYAMKLLSKFEMIKRSDSAFFWEERDIMA 145
+K D++++ +G G FG V+LV+ K+ + K +AMK+L K ++ E+ IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 429
Query: 146 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWAKFYTAEVVLALDA 204
A+S ++V+L+ F+D +YLYM+ME GG+L ++ + + +FYTA VV A
Sbjct: 430 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 489
Query: 205 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 264
+HS G+I+RD+KP+N++LD G+ KL DFG K+ T GTP+Y++PE++ +
Sbjct: 490 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW--TFCGTPEYVAPEIILN 547
Query: 265 QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKH 324
+G D D+WS+G+ +YE+L G PF + TY+ I+ + + FP+ +I+K+
Sbjct: 548 KGHD----ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPK--KIAKN 601
Query: 325 AKNLICAFLTDR-EVRLG--RNGVEEIRQHPFFKNDQWHWDNIRE--TAAPVVPELSSDI 379
A NLI D RLG +NGV++I++H +F+ ++W+ +R+ P++P ++S
Sbjct: 602 AANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEG--FNWEGLRKGTLTPPIIPSVASPT 659
Query: 380 DSSNFDDIEDDKGD 393
D+SNFD +D +
Sbjct: 660 DTSNFDSFPEDNDE 673
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 195 bits (495), Expect = 3e-49
Identities = 124/339 (36%), Positives = 192/339 (56%), Gaps = 18/339 (5%)
Query: 90 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA-N 148
++++ ++V+G+G+FG+V L R K + +YA+K+L K +++ D E+ I++ A N
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412
Query: 149 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVPEKWAKFYTAEVVLALDAIHS 207
P++ QLF FQ L+ VME++ GGDL+ ++ + E A+FY AE++ AL +H
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 472
Query: 208 MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGG 267
G+I+RD+K DN+LLD GH KLADFG C + G V T GTPDYI+PE+L+
Sbjct: 473 KGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNG-VTTATFCGTPDYIAPEILQEM-- 529
Query: 268 DGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKN 327
YG DWW++GV LYEML G PF A++ + I++ + + +P + + A
Sbjct: 530 --LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN--DEVVYP--TWLHEDATG 583
Query: 328 LICAFLT-DREVRLG---RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSN 383
++ +F+T + +RLG + G I +HPFFK W N R+ P P + S D SN
Sbjct: 584 ILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSN 643
Query: 384 FDDIEDDKGDVETFPIPKAFVG--NQLPFIGFTYYRENL 420
FD + K + PI + + NQ F F+Y L
Sbjct: 644 FDP-DFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
Score = 32.0 bits (71), Expect = 4.2
Identities = 15/46 (32%), Positives = 23/46 (50%), Gaps = 5/46 (10%)
Query: 1260 GHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRC----HIKCH 1301
GH+F+ T PT C C + +W +F +C+ C H +CH
Sbjct: 171 GHKFMATYLRQPTYCSHCREFIWGVF-GKQGYQCQVCTCVVHKRCH 215
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 194 bits (493), Expect = 5e-49
Identities = 117/315 (37%), Positives = 179/315 (56%), Gaps = 14/315 (4%)
Query: 76 EKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSA 135
E V K R ++ D+D +K++G+G FG+V LVR KA+ + YAMK+L K +I + + A
Sbjct: 137 EVAVSKARA-KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVA 195
Query: 136 FFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFY 194
E ++ P++ L YAFQ L VMEY GG+L +S V E+ A+FY
Sbjct: 196 HTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFY 255
Query: 195 TAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTP 254
AE+V AL+ +HS +++RD+K +N++LDK GH+K+ DFG C + G T GTP
Sbjct: 256 GAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGAT-MKTFCGTP 314
Query: 255 DYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLC 314
+Y++PEVL+ D YGR DWW +GV +YEM+ G PFY + I+ +
Sbjct: 315 EYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL--MEEIR 368
Query: 315 FPEDAEISKHAKNLICAFL-TDREVRL--GRNGVEEIRQHPFFKNDQWHWDNIRETAAPV 371
FP +S AK+L+ L D + RL G + +E+ +H FF + W ++ P
Sbjct: 369 FPR--TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPF 426
Query: 372 VPELSSDIDSSNFDD 386
P+++S++D+ FDD
Sbjct: 427 KPQVTSEVDTRYFDD 441
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 193 bits (491), Expect = 8e-49
Identities = 150/475 (31%), Positives = 250/475 (52%), Gaps = 51/475 (10%)
Query: 63 RKNKNIDNFLNRYEK--IVKKI-------RGLQMKAE--DYDVVKVIGRGAFGEVQLVRH 111
RK+++ + L+R E+ +VK+I G + KA+ ++++KV+G+G++G+V LVR
Sbjct: 20 RKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRK 78
Query: 112 -KASQ--KVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMV 168
K S ++YAMK+L K +K D ERDI+A N P++V+L YAFQ + LY++
Sbjct: 79 VKGSDAGQLYAMKVLKK-ATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLI 137
Query: 169 MEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGH 227
++++ GGDL +S + E+ KFY AE+ LALD +HS+G+I+RD+KP+N+LLD+ GH
Sbjct: 138 LDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGH 197
Query: 228 LKLADFG---TCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFL 284
+K+ DFG + D+ C GT +Y++PEV+ +G + + DWWS GV +
Sbjct: 198 IKITDFGLSKEAIDHDKRAYSFC----GTIEYMAPEVVNRRG----HTQSADWWSFGVLM 249
Query: 285 YEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTD---REVRLG 341
+EML G PF T + I+ K L P+ +S A++L+ A + G
Sbjct: 250 FEMLTGSLPFQGKDRKETMALIL--KAKLGMPQ--FLSGEAQSLLRALFKRNPCNRLGAG 305
Query: 342 RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPK 401
+GVEEI++HPFF W+ +E P P + D+ +FD + ++ +P
Sbjct: 306 IDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPP 365
Query: 402 AFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQ 461
+ + L F GF++ +L+ + S Q I ++L+ H ++ +
Sbjct: 366 SANAHHL-FRGFSFVASSLI--------QEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYE 416
Query: 462 AKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALL----QHKN 512
KE++ SV R A + E + K ++ + R E +L QH N
Sbjct: 417 IKEDIGVGSYSVCKRCVHKATDTEYAV---KIIDKSKRDPSEEIEILLRYGQHPN 468
Score = 113 bits (282), Expect = 1e-24
Identities = 87/292 (29%), Positives = 149/292 (51%), Gaps = 24/292 (8%)
Query: 78 IVKKIRGLQMKAED-YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAF 136
IV+++ G + D Y++ + IG G++ + HKA+ YA+K++ K KR S
Sbjct: 400 IVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS---KRDPSE- 455
Query: 137 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWAKFYT 195
E ++ + P ++ L + D +++Y+VME M GG+L++ ++ E+ A
Sbjct: 456 --EIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVL 513
Query: 196 AEVVLALDAIHSMGLIHRDVKPDNMLL-DKHGH---LKLADFGTCMKMDETGMVHCDTAV 251
+ +D +HS G++HRD+KP N+L D+ G +++ DFG ++ G T
Sbjct: 514 CTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQL-RAGNGLLMTPC 572
Query: 252 GTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFY---ADSLVGTYSKIMD 308
T ++++PEVLK QG Y CD WS+G+ LY ML G TPF D+ ++I
Sbjct: 573 YTANFVAPEVLKRQG----YDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGS 628
Query: 309 HKNSLCFPEDAEISKHAKNLICAFL-TDREVRLGRNGVEEIRQHPFFKNDQW 359
K +L IS AK+++ L D RL ++ +HP+ N ++
Sbjct: 629 GKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL---TAMQVLKHPWVVNREY 677
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,805,727
Number of Sequences: 37866
Number of extensions: 2449527
Number of successful extensions: 39289
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1124
Number of HSP's successfully gapped in prelim test: 1685
Number of HSP's that attempted gapping in prelim test: 11173
Number of HSP's gapped (non-prelim): 11551
length of query: 1388
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1273
effective length of database: 13,892,928
effective search space: 17685697344
effective search space used: 17685697344
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.