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Search of human proteins with 41393573
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41393573 G protein-coupled receptor kinase interactor 1
isoform 2 [Homo sapiens]
(761 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 1521 0.0
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 1514 0.0
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 956 0.0
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 936 0.0
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 851 0.0
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 850 0.0
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 732 0.0
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 716 0.0
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 129 1e-29
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 126 9e-29
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 126 9e-29
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 124 3e-28
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 123 7e-28
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 123 7e-28
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 123 7e-28
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 122 1e-27
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 119 1e-26
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 118 2e-26
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 115 2e-25
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 107 3e-23
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 107 3e-23
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 86 2e-16
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 86 2e-16
gi|7661880 centaurin beta1 [Homo sapiens] 85 3e-16
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 81 3e-15
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 79 2e-14
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 79 2e-14
gi|187608516 centaurin, beta 2 [Homo sapiens] 77 8e-14
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 72 2e-12
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 72 2e-12
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
2 [Homo sapiens]
Length = 761
Score = 1521 bits (3939), Expect = 0.0
Identities = 761/761 (100%), Positives = 761/761 (100%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL
Sbjct: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL
Sbjct: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT
Sbjct: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGHYIIPQMADSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQ 300
HKNGHYIIPQMADSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQ
Sbjct: 241 HKNGHYIIPQMADSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQ 300
Query: 301 NHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSL 360
NHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSL
Sbjct: 301 NHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSL 360
Query: 361 SSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDGA 420
SSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDGA
Sbjct: 361 SSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDGA 420
Query: 421 VTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPT 480
VTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPT
Sbjct: 421 VTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPT 480
Query: 481 PPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRLQPFHSTELE 540
PPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRLQPFHSTELE
Sbjct: 481 PPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRLQPFHSTELE 540
Query: 541 DDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYEN 600
DDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYEN
Sbjct: 541 DDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYEN 600
Query: 601 TQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELL 660
TQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELL
Sbjct: 601 TQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELL 660
Query: 661 RAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTV 720
RAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTV
Sbjct: 661 RAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTV 720
Query: 721 PPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 761
PPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ
Sbjct: 721 PPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 761
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
1 [Homo sapiens]
Length = 770
Score = 1514 bits (3919), Expect = 0.0
Identities = 761/770 (98%), Positives = 761/770 (98%), Gaps = 9/770 (1%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL
Sbjct: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL
Sbjct: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT
Sbjct: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGHYIIPQMAD---------SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE 291
HKNGHYIIPQMAD SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE
Sbjct: 241 HKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRE 300
Query: 292 NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA 351
NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA
Sbjct: 301 NDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEA 360
Query: 352 KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411
KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM
Sbjct: 361 KRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 420
Query: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 471
DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL
Sbjct: 421 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 480
Query: 472 RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL 531
RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL
Sbjct: 481 RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRL 540
Query: 532 QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG 591
QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG
Sbjct: 541 QPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHG 600
Query: 592 SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ 651
SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ
Sbjct: 601 SGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQ 660
Query: 652 VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR 711
VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR
Sbjct: 661 VTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYR 720
Query: 712 LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 761
LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ
Sbjct: 721 LQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 770
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 956 bits (2470), Expect = 0.0
Identities = 514/781 (65%), Positives = 604/781 (77%), Gaps = 48/781 (6%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMAD-SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLA 298
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRRE DAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 299 TQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGK 358
TQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+AKRRQQG
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 359 SLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411
SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+++NR +S+
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNRQKSL 416
Query: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 471
D SDLSDG VT+QE++E+K AL SEAK+QQLMKVN++LSDELR +Q+++ LQ+EN L
Sbjct: 417 D-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNL 475
Query: 472 RQPPG----PVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPG--- 524
R+ V T ++ + H+ + S R + SMYE GS KP+ P G
Sbjct: 476 RKQATTNVYQVQTGSEYTDTSNHSSLKRRPSA--RGSRPMSMYETGSGQKPY-LPMGEAS 532
Query: 525 --DELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQ-EGS 581
+E RLQPF PA + R S+S++P PS+ LS S+ E +
Sbjct: 533 RPEESRMRLQPF---------------PAHIGRSALVTSSSSLPSFPST--LSWSRDESA 575
Query: 582 RHTSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDP 637
R S+L + S +SDY+NT + G+ +G++ + + P+ P
Sbjct: 576 RRASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSP 635
Query: 638 GLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEP 697
LPSTEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P +
Sbjct: 636 TLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDM 695
Query: 698 VRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTR 757
VR+SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+
Sbjct: 696 VRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTK 755
Query: 758 E 758
E
Sbjct: 756 E 756
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 936 bits (2419), Expect = 0.0
Identities = 504/780 (64%), Positives = 587/780 (75%), Gaps = 76/780 (9%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMAD-SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLA 298
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRRE DAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 299 TQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGK 358
TQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+AKRRQQG
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 359 SLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411
SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+++NR +S+
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNRQKSL 416
Query: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 471
D SDLSDG VT+QE++E+K AL SEAK+QQLMKVN++LSDELR +Q+++ LQ+EN L
Sbjct: 417 D-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNL 475
Query: 472 RQPPG----PVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPG--- 524
R+ V T ++ + H+ + S R + SMYE GS KP+ P G
Sbjct: 476 RKQATTNVYQVQTGSEYTDTSNHSSLKRRPSA--RGSRPMSMYETGSGQKPY-LPMGEAS 532
Query: 525 --DELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSR 582
+E RLQPF PA
Sbjct: 533 RPEESRMRLQPF---------------PA------------------------------- 546
Query: 583 HTSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPG 638
H S+L + S +SDY+NT + G+ +G++ + + P+ P
Sbjct: 547 HASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPT 606
Query: 639 LPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPV 698
LPSTEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P + V
Sbjct: 607 LPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMV 666
Query: 699 RSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTRE 758
R+SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+E
Sbjct: 667 RTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKE 726
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 851 bits (2198), Expect = 0.0
Identities = 471/776 (60%), Positives = 543/776 (69%), Gaps = 118/776 (15%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMAD-SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLA 298
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRRE DAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 299 TQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGK 358
TQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+AKRRQQG
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 359 SLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411
SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+++NR
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNR---- 412
Query: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 471
K+Q L NS+L ++ ++++Q
Sbjct: 413 --------------------------QKLQTLQSENSNLR---KQATTNVYQVQT----- 438
Query: 472 RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPG-----DE 526
G T + P A G + SMYE GS KP+ P G +E
Sbjct: 439 ----GSEYTDTSNHSSLKRRPSARGS-------RPMSMYETGSGQKPY-LPMGEASRPEE 486
Query: 527 LTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSK 586
RLQPF PA H S+
Sbjct: 487 SRMRLQPF---------------PA-------------------------------HASR 500
Query: 587 LSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPGLPST 642
L + S +SDY+NT + G+ +G++ + + P+ P LPST
Sbjct: 501 LEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPST 560
Query: 643 EDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSL 702
EDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P + VR+SL
Sbjct: 561 EDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSL 620
Query: 703 RLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTRE 758
RLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+E
Sbjct: 621 RLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKE 676
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 850 bits (2196), Expect = 0.0
Identities = 471/778 (60%), Positives = 543/778 (69%), Gaps = 120/778 (15%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMAD---SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVW 296
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRRE DAVW
Sbjct: 241 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 300
Query: 297 LATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQ 356
LATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+AKRRQQ
Sbjct: 301 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 360
Query: 357 GKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRAR 409
G SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+++NR
Sbjct: 361 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNR-- 414
Query: 410 SMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENL 469
K+Q L NS+L ++ ++++Q
Sbjct: 415 ----------------------------QKLQTLQSENSNLR---KQATTNVYQVQT--- 440
Query: 470 QLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPG----- 524
G T + P A G + SMYE GS KP+ P G
Sbjct: 441 ------GSEYTDTSNHSSLKRRPSARGS-------RPMSMYETGSGQKPY-LPMGEASRP 486
Query: 525 DELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHT 584
+E RLQPF PA H
Sbjct: 487 EESRMRLQPF---------------PA-------------------------------HA 500
Query: 585 SKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPGLP 640
S+L + S +SDY+NT + G+ +G++ + + P+ P LP
Sbjct: 501 SRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLP 560
Query: 641 STEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRS 700
STEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P + VR+
Sbjct: 561 STEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRT 620
Query: 701 SLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTRE 758
SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+E
Sbjct: 621 SLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKE 678
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 732 bits (1889), Expect = 0.0
Identities = 367/470 (78%), Positives = 412/470 (87%), Gaps = 14/470 (2%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMAD-SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLA 298
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRRE DAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 299 TQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGK 358
TQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+AKRRQQG
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 359 SLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411
SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+++NR +S+
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNRQKSL 416
Query: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREI 461
D SDLSDG VT+QE++E+K AL SEAK+QQLMKVN++LSDELR +Q+++
Sbjct: 417 D-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKL 465
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 716 bits (1847), Expect = 0.0
Identities = 374/534 (70%), Positives = 420/534 (78%), Gaps = 44/534 (8%)
Query: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNG-HYIIPQMAD-SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLA 298
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRRE DAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 299 TQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGK 358
TQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+AKRRQQG
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 359 SLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411
SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+++NR +S+
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNRQKSL 416
Query: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 471
D SDLSDG VT+QE++E+K AL SEAK+QQLMK + +L+ +N
Sbjct: 417 D-SDLSDGPVTVQEFMEVKNALVASEAKIQQLMKAS---------------RLEKQN--- 457
Query: 472 RQPPGPVPTPPLPSERAEHTP--MAPGGSTHRRDRQAFSMYEPGSALKPFGGPP 523
P ++TP M P G R + SM PG L P P
Sbjct: 458 ----------STPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEP 501
Score = 204 bits (520), Expect = 2e-52
Identities = 107/178 (60%), Positives = 135/178 (75%), Gaps = 4/178 (2%)
Query: 585 SKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPGLP 640
S+L + S +SDY+NT + G+ +G++ + + P+ P LP
Sbjct: 451 SRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLP 510
Query: 641 STEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRS 700
STEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P + VR+
Sbjct: 511 STEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRT 570
Query: 701 SLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTRE 758
SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+E
Sbjct: 571 SLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKE 628
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 129 bits (324), Expect = 1e-29
Identities = 77/214 (35%), Positives = 112/214 (52%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC AP+P WAS++ G L+C EC +HR LG H+S V+ L WPP LL ++ + +
Sbjct: 677 CIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNA 736
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANS+WE +L G K P D K +IRAKY+ F+ LP D
Sbjct: 737 LANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPSSD------ 782
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGTTPLHVAAKAGQTLQAELLV 187
L +QL +V +L + LL+ G++ + G T LH+++ + +LL+
Sbjct: 783 VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLI 842
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D S D G TP+ YAR+AG E A+ L++
Sbjct: 843 WYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 126 bits (316), Expect = 9e-29
Identities = 73/214 (34%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ G L+C EC +HR+LG H+S V+ L WP L++++ ++ +
Sbjct: 571 CVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNE 630
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANS+WE S GR K + D K +IRAKY+ F+ LPC T
Sbjct: 631 LANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC------TE 676
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 677 LSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLI 736
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E + L++
Sbjct: 737 WYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 770
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 126 bits (316), Expect = 9e-29
Identities = 73/214 (34%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ G L+C EC +HR+LG H+S V+ L WP L++++ ++ +
Sbjct: 624 CVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNE 683
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANS+WE S GR K + D K +IRAKY+ F+ LPC T
Sbjct: 684 LANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC------TE 729
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 730 LSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLI 789
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E + L++
Sbjct: 790 WYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 124 bits (311), Expect = 3e-28
Identities = 76/214 (35%), Positives = 115/214 (53%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRSLG H+S V+ L WP L +++ ++ ++
Sbjct: 479 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVND 538
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 539 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 584
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G+ + N E G T LH+A + G + A+LL+
Sbjct: 585 LSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLI 644
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 645 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 123 bits (308), Expect = 7e-28
Identities = 73/215 (33%), Positives = 115/215 (53%), Gaps = 17/215 (7%)
Query: 10 VCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69
+C DC AP+P WAS++ G L+C EC +HR+LG H+S V+ L WP L ++ + +
Sbjct: 945 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 1004
Query: 70 NGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVT 129
+ AN +WE GR K + +D + +IRAKY+ L F+ L +
Sbjct: 1005 DTANRVWESD-------TRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL------STS 1050
Query: 130 AKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGTTPLHVAAKAGQTLQAELL 186
+ L +QL ++V+ ++ T L LL+ G + +PLH+AA+ + +LL
Sbjct: 1051 EEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLL 1110
Query: 187 VVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
+ YGAD + D GRT + YARQAG A+ L++
Sbjct: 1111 LWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 123 bits (308), Expect = 7e-28
Identities = 73/215 (33%), Positives = 115/215 (53%), Gaps = 17/215 (7%)
Query: 10 VCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69
+C DC AP+P WAS++ G L+C EC +HR+LG H+S V+ L WP L ++ + +
Sbjct: 589 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 648
Query: 70 NGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVT 129
+ AN +WE GR K + +D + +IRAKY+ L F+ L +
Sbjct: 649 DTANRVWESD-------TRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL------STS 694
Query: 130 AKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGTTPLHVAAKAGQTLQAELL 186
+ L +QL ++V+ ++ T L LL+ G + +PLH+AA+ + +LL
Sbjct: 695 EEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLL 754
Query: 187 VVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
+ YGAD + D GRT + YARQAG A+ L++
Sbjct: 755 LWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 123 bits (308), Expect = 7e-28
Identities = 74/214 (34%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 456 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S GR K + K +IR+KY+ F+ LPC T
Sbjct: 516 LANSIWEGS-------SQGRTKPT-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 562 LSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 122 bits (306), Expect = 1e-27
Identities = 76/222 (34%), Positives = 115/222 (51%), Gaps = 19/222 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 456 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 516 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 562 LSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDR 229
YG D + D +G T + YARQA E L+ QY D+
Sbjct: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLL--QYGCPDK 661
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 119 bits (298), Expect = 1e-26
Identities = 72/214 (33%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +H SLG +S V+ L WP L +++ ++ ++
Sbjct: 456 CVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 516 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 562 LSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 118 bits (296), Expect = 2e-26
Identities = 72/214 (33%), Positives = 110/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 343 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 402
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 403 LANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC------TE 448
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 449 LSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 508
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 509 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 115 bits (287), Expect = 2e-25
Identities = 71/214 (33%), Positives = 110/214 (51%), Gaps = 17/214 (7%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C D +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 479 CVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 538
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 539 LANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC------TE 584
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L + L + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 585 LSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 644
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
YG D + D +G T + YARQA E L++
Sbjct: 645 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 107 bits (268), Expect = 3e-23
Identities = 70/214 (32%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRS G +S V+ L WP L +++ ++ +
Sbjct: 479 CVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNE 538
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 539 LANSIWEGS-------SQGQTKPSIK-STREEKEWWIRSKYEEKLFLAPLPC------TE 584
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + +LL
Sbjct: 585 LSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL- 643
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
G D + D +G T + YARQA E L++
Sbjct: 644 -XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 107 bits (268), Expect = 3e-23
Identities = 70/214 (32%), Positives = 107/214 (50%), Gaps = 19/214 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC +P WAS++ GVL+C EC +HRS G +S V+ L WP L +++ ++ +
Sbjct: 479 CVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNE 538
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 539 LANSIWEGS-------SQGQTKPSIK-STREEKEWWIRSKYEEKLFLAPLPC------TE 584
Query: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
L +QL + +L+T + LL+ G++ G T LH+A + G + +LL
Sbjct: 585 LSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL- 643
Query: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
G D + D +G T + YARQA E L++
Sbjct: 644 -XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 85.5 bits (210), Expect = 2e-16
Identities = 57/179 (31%), Positives = 88/179 (49%), Gaps = 15/179 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLR--HSAWPPTLLQMVHTLA 68
CADC AP P WASI+ V++C C HR LG +S V+ L+ W TL+++ L
Sbjct: 305 CADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLG 364
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
+ N W ++ +Q ++P + +++++ KY+ H L +
Sbjct: 365 NGAGNRFWAANVPPSEALQP---SSSPSTRRCHLEAKYREGKYRR---YHPLFGNQE--- 415
Query: 129 TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPE-KGTTPLHVAAKAGQTLQAELL 186
+L K L ++V T +L LL GA N F + + TPL +A +AGQTLQ E L
Sbjct: 416 ---ELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFL 471
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 85.5 bits (210), Expect = 2e-16
Identities = 57/179 (31%), Positives = 88/179 (49%), Gaps = 15/179 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLR--HSAWPPTLLQMVHTLA 68
CADC AP P WASI+ V++C C HR LG +S V+ L+ W TL+++ L
Sbjct: 550 CADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLG 609
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
+ N W ++ +Q ++P + +++++ KY+ H L +
Sbjct: 610 NGAGNRFWAANVPPSEALQP---SSSPSTRRCHLEAKYREGKYRR---YHPLFGNQE--- 660
Query: 129 TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPE-KGTTPLHVAAKAGQTLQAELL 186
+L K L ++V T +L LL GA N F + + TPL +A +AGQTLQ E L
Sbjct: 661 ---ELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFL 716
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 84.7 bits (208), Expect = 3e-16
Identities = 83/322 (25%), Positives = 129/322 (40%), Gaps = 55/322 (17%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC P P WASI+ GV +C +C +HRSLG H S V+ L +W P L++++ L +
Sbjct: 420 CCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNV 479
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLP--------- 121
N I+E A+V++ K K +I AKY F+ KLP
Sbjct: 480 IINQIYE------ARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGR 533
Query: 122 ---------------------CRDDDGVTAKDLSKQLH-------SSVRTGNLETCLRLL 153
R ++DL LH +S +L T L
Sbjct: 534 GRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLG-SLHPGALLFRASGHPPSLPTMADAL 592
Query: 154 SLGAQANFFH-PEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGH 212
+ GA N+ + + TPL A A L E L+ GA+ D GR P+ +A GH
Sbjct: 593 AHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGH 652
Query: 213 HELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADSLDLSELAKAAK-KKLQAL 271
LA ++ +L G + I + D+ L + AK ++ +A
Sbjct: 653 TGLACLFLKRGADL---------GARDSEGRDPLTIAMETANADIVTLLRLAKMREAEAA 703
Query: 272 SNRLFEELAMDVYDEVDRREND 293
+ +E +D++ + +D
Sbjct: 704 QGQAGDETYLDIFRDFSLMASD 725
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 81.3 bits (199), Expect = 3e-15
Identities = 40/101 (39%), Positives = 60/101 (59%), Gaps = 1/101 (0%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC PDP WASI+ GVL+C EC +HRSLG H S V+ L +W P LL+++ L ++
Sbjct: 418 CGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNS 477
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKY 111
N I+E + + A + ++ QDK IK +++ K+
Sbjct: 478 AVNQIYE-AQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKF 517
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/75 (33%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 138 HSSVRTGNLETCLRLLSLGAQANFFHPE-KGTTPLHVAAKAGQTLQAELLVVYGADPGSP 196
H + R +L L+ GA+ N+ E +G TPL A G + E L+ GAD
Sbjct: 673 HRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQR 732
Query: 197 DVNGRTPIDYARQAG 211
D GR P+ +A G
Sbjct: 733 DSRGRAPLHHATLLG 747
Score = 39.3 bits (90), Expect = 0.014
Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 124 DDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQA 183
+D+G T L +V G+L C LL GA N +G PLH A G+T Q
Sbjct: 700 EDEGKTP------LVQAVLGGSLIVCEFLLQNGADVNQ-RDSRGRAPLHHATLLGRTGQV 752
Query: 184 ELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERL 219
L + GAD + D R P+ A QA + ++ L
Sbjct: 753 CLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLL 788
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
2 [Homo sapiens]
Length = 1704
Score = 79.0 bits (193), Expect = 2e-14
Identities = 59/179 (32%), Positives = 88/179 (49%), Gaps = 15/179 (8%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSA--WPPTLLQMVHTLA 68
CADC APDP WASI+ V++C +C HRSLG S V+ L+ A W L+++ +
Sbjct: 700 CADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIG 759
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
+ AN W +L Q +P +K + FI KY+ F L +
Sbjct: 760 NKRANDFWAGNL----QKDEELHMDSPVEK----RKNFITQKYKEGKFRKTLLA----SL 807
Query: 129 TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEK-GTTPLHVAAKAGQTLQAELL 186
T ++L+K L ++V ++ + LL GA + +TP +A KAGQ+LQ E L
Sbjct: 808 TKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFL 866
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 78.6 bits (192), Expect = 2e-14
Identities = 55/180 (30%), Positives = 88/180 (48%), Gaps = 19/180 (10%)
Query: 46 SIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDK-VHPIKS 104
S V+ L WP L +++ ++ ++ ANSIWE S + + P +K K
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS---------SQGQTKPSEKSTREEKE 162
Query: 105 EFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHP 164
+IR+KY+ F+ LPC D L +QL + +L+T + LL+ G++
Sbjct: 163 RWIRSKYEEKLFLAPLPCTD------LSLGQQLLRATADEDLQTAILLLAHGSREEVNET 216
Query: 165 ---EKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
G T LH+A + G + A+LL+ YG D + D +G T + YARQA E L++
Sbjct: 217 CGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 276
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 76.6 bits (187), Expect = 8e-14
Identities = 41/109 (37%), Positives = 59/109 (54%), Gaps = 7/109 (6%)
Query: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
C DC DP WASI+ G+ +C EC +HRSLG H S V+ L W P LL+++ L ++
Sbjct: 414 CCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGND 473
Query: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHK 119
N ++E ++ + G +K P + K +IRAKY FV K
Sbjct: 474 VINRVYEANV-----EKMGIKKPQPGQRQE--KEAYIRAKYVERKFVDK 515
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 136 QLHSSVRTGNLETCLRLLSLGAQANFFHPEKG-TTPLHVAAKAGQTLQAELLVVYGADPG 194
QL+ + NL L+ GA N+ + E+ TPL A G + E L+ GA+
Sbjct: 609 QLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVN 668
Query: 195 SPDVNGRTPIDYARQAGH 212
DV GR P+ +A GH
Sbjct: 669 QRDVQGRGPLHHATVLGH 686
Score = 40.0 bits (92), Expect = 0.008
Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Query: 137 LHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSP 196
L +V G+L TC LL GA N +G PLH A G T Q L + GA+ +
Sbjct: 645 LIQAVLGGSLVTCEFLLQNGANVNQ-RDVQGRGPLHHATVLGHTGQVCLFLKRGANQHAT 703
Query: 197 DVNGRTPIDYARQAGHHELAE--RLVECQYELTDRLAFY 233
D G+ P+ A +A + ++ RL E+ + Y
Sbjct: 704 DEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLY 742
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/353 (25%), Positives = 141/353 (39%), Gaps = 59/353 (16%)
Query: 9 EVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLA 68
+VC DC APDP W S + G+L C EC +HR LG H S ++ L + L + +
Sbjct: 434 DVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIG 493
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHK--------- 119
+ G N I E L PA+ K NP ++ + ++I AKY + K
Sbjct: 494 NAGFNEIMECCL--PAE---DSVKPNPGSDMN-ARKDYITAKYIERRYARKKHADNAAKL 547
Query: 120 ------LPCRDDDGV-----TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH----- 163
+ RD G+ DL++++ + ET L L H
Sbjct: 548 HSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFL 607
Query: 164 ----------PEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHH 213
KG+T LH +LL+ A + +G TP+D A++ H
Sbjct: 608 VQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHE 667
Query: 214 ELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADSLDLSELAKAAKKKLQALSN 273
E L + L GR H + Y + + LD S+ +KLQ N
Sbjct: 668 HCEELLTQA-----------LSGRFNSHVHVEYEWRLLHEDLDESD--DDMDEKLQPSPN 714
Query: 274 RLFEELAMDVYD-EVDRRENDAVWLATQNHSTLVTE--RSAVPFLPVNPEYSA 323
R E+ + Y ++ +++AV LA ++ + L E R+ +P + N Y A
Sbjct: 715 RR-EDRPISFYQLGSNQLQSNAVSLA-RDAANLAKEKQRAFMPSILQNETYGA 765
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/353 (25%), Positives = 141/353 (39%), Gaps = 59/353 (16%)
Query: 9 EVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLA 68
+VC DC APDP W S + G+L C EC +HR LG H S ++ L + L + +
Sbjct: 434 DVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIG 493
Query: 69 SNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHK--------- 119
+ G N I E L PA+ K NP ++ + ++I AKY + K
Sbjct: 494 NAGFNEIMECCL--PAE---DSVKPNPGSDMN-ARKDYITAKYIERRYARKKHADNAAKL 547
Query: 120 ------LPCRDDDGV-----TAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH----- 163
+ RD G+ DL++++ + ET L L H
Sbjct: 548 HSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFL 607
Query: 164 ----------PEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHH 213
KG+T LH +LL+ A + +G TP+D A++ H
Sbjct: 608 VQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHE 667
Query: 214 ELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADSLDLSELAKAAKKKLQALSN 273
E L + L GR H + Y + + LD S+ +KLQ N
Sbjct: 668 HCEELLTQA-----------LSGRFNSHVHVEYEWRLLHEDLDESD--DDMDEKLQPSPN 714
Query: 274 RLFEELAMDVYD-EVDRRENDAVWLATQNHSTLVTE--RSAVPFLPVNPEYSA 323
R E+ + Y ++ +++AV LA ++ + L E R+ +P + N Y A
Sbjct: 715 RR-EDRPISFYQLGSNQLQSNAVSLA-RDAANLAKEKQRAFMPSILQNETYGA 765
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,596,541
Number of Sequences: 37866
Number of extensions: 1579822
Number of successful extensions: 10514
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 318
Number of HSP's successfully gapped in prelim test: 184
Number of HSP's that attempted gapping in prelim test: 8470
Number of HSP's gapped (non-prelim): 1893
length of query: 761
length of database: 18,247,518
effective HSP length: 110
effective length of query: 651
effective length of database: 14,082,258
effective search space: 9167549958
effective search space used: 9167549958
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.