Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 41281709
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41281709 nuclear factor of kappa light polypeptide gene
enhancer in B-cells inhibitor, delta [Homo sapiens]
(313 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41281709 nuclear factor of kappa light polypeptide gene enhan... 620 e-178
gi|53832024 nuclear factor of kappa light polypeptide gene enhan... 206 3e-53
gi|13899229 nuclear factor of kappa light polypeptide gene enhan... 206 3e-53
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] 106 2e-23
gi|117320531 nuclear factor of kappa light polypeptide gene enha... 101 7e-22
gi|117320540 nuclear factor of kappa light polypeptide gene enha... 101 7e-22
gi|117320527 nuclear factor of kappa light polypeptide gene enha... 101 7e-22
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] 89 5e-18
gi|71274109 nuclear factor of kappa light polypeptide gene enhan... 85 9e-17
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 77 3e-14
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 74 2e-13
gi|10092619 nuclear factor of kappa light polypeptide gene enhan... 69 4e-12
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 69 4e-12
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 69 4e-12
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 69 7e-12
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 69 7e-12
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 69 7e-12
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 69 7e-12
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 69 7e-12
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 67 2e-11
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 67 2e-11
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 65 6e-11
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 65 6e-11
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 64 1e-10
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 64 1e-10
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 64 1e-10
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 64 2e-10
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 64 2e-10
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 64 2e-10
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 62 5e-10
>gi|41281709 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, delta [Homo sapiens]
Length = 313
Score = 620 bits (1599), Expect = e-178
Identities = 313/313 (100%), Positives = 313/313 (100%)
Query: 1 MEAGPWRVSAPPSGPPQFPAVVPGPSLEVARAHMLALGPQQLLAQDEEGDTLLHLFAARG 60
MEAGPWRVSAPPSGPPQFPAVVPGPSLEVARAHMLALGPQQLLAQDEEGDTLLHLFAARG
Sbjct: 1 MEAGPWRVSAPPSGPPQFPAVVPGPSLEVARAHMLALGPQQLLAQDEEGDTLLHLFAARG 60
Query: 61 LRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRS 120
LRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRS
Sbjct: 61 LRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRS 120
Query: 121 VLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLST 180
VLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLST
Sbjct: 121 VLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLST 180
Query: 181 QARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNM 240
QARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNM
Sbjct: 181 QARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNM 240
Query: 241 KAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQL 300
KAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQL
Sbjct: 241 KAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQL 300
Query: 301 LKRSRVAPPGLSS 313
LKRSRVAPPGLSS
Sbjct: 301 LKRSRVAPPGLSS 313
>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, zeta isoform b [Homo sapiens]
Length = 618
Score = 206 bits (523), Expect = 3e-53
Identities = 126/298 (42%), Positives = 178/298 (59%), Gaps = 17/298 (5%)
Query: 27 LEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGK 86
+E + + + Q L++D +GDT LH+ A+G R +Y A + LDI+EH G+
Sbjct: 322 VEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQ 381
Query: 87 TPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV----LNSGV 142
+ VA AANQ LIV+DL+N+GA+ N D GR+ LHV A G VL A+ + S
Sbjct: 382 SAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQ 441
Query: 143 QVDLEARDFEGLTPLHTAILALNVAM-------RPSDLCPRVLSTQARDRLDCVHMLLQM 195
VDLEA +++GLTPLH A++A N + +P + L + + +D + L+QM
Sbjct: 442 FVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM 501
Query: 196 GANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAAL 254
GA +++ KS +T LHLA + AN L++L LELP +FVN KA+ GNTALH+AA+L
Sbjct: 502 GAAVEAKDRKSGRTALHLAAEEANLELIRLFLELP--SCLSFVNAKAYNGNTALHVAASL 559
Query: 255 PPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRV---APP 309
Q VR L+ GADP+ RNLENEQPVHL+ GP E +R++LK + APP
Sbjct: 560 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPP 617
>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, zeta isoform a [Homo sapiens]
Length = 718
Score = 206 bits (523), Expect = 3e-53
Identities = 126/298 (42%), Positives = 178/298 (59%), Gaps = 17/298 (5%)
Query: 27 LEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGK 86
+E + + + Q L++D +GDT LH+ A+G R +Y A + LDI+EH G+
Sbjct: 422 VEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQ 481
Query: 87 TPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV----LNSGV 142
+ VA AANQ LIV+DL+N+GA+ N D GR+ LHV A G VL A+ + S
Sbjct: 482 SAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQ 541
Query: 143 QVDLEARDFEGLTPLHTAILALNVAM-------RPSDLCPRVLSTQARDRLDCVHMLLQM 195
VDLEA +++GLTPLH A++A N + +P + L + + +D + L+QM
Sbjct: 542 FVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQM 601
Query: 196 GANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAAL 254
GA +++ KS +T LHLA + AN L++L LELP +FVN KA+ GNTALH+AA+L
Sbjct: 602 GAAVEAKDRKSGRTALHLAAEEANLELIRLFLELP--SCLSFVNAKAYNGNTALHVAASL 659
Query: 255 PPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRV---APP 309
Q VR L+ GADP+ RNLENEQPVHL+ GP E +R++LK + APP
Sbjct: 660 QYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPP 717
>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
Length = 454
Score = 106 bits (265), Expect = 2e-23
Identities = 86/278 (30%), Positives = 139/278 (50%), Gaps = 40/278 (14%)
Query: 16 PQFPAVVPGPSLEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVY 75
P +P + P H L+ DE+GDT LH+ +G A + + Q
Sbjct: 109 PLYPMMCP-------MEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQG 161
Query: 76 -RRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVL 134
R LDI + +TPL +A P +V L+ GA P A D G++ H+A + P L
Sbjct: 162 GRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCL 221
Query: 135 LAVLNSGV--QVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHML 192
A+L+S +DLEAR+++GLT LH A+ +T+ + + V +L
Sbjct: 222 RALLDSAAPGTLDLEARNYDGLTALHVAV-----------------NTECQ---ETVQLL 261
Query: 193 LQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMA 251
L+ GA+ + +IKS ++ L AV+ + ++VQLLL+ VN + + G++ALH A
Sbjct: 262 LERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGAN-----VNAQMYSGSSALHSA 316
Query: 252 AALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLR 289
+ G +VR L+ +GAD +L+N N+ P+ + R
Sbjct: 317 S----GRGLLPLVRTLVRSGADSSLKNCHNDTPLMVAR 350
Score = 36.2 bits (82), Expect = 0.039
Identities = 39/157 (24%), Positives = 59/157 (37%), Gaps = 27/157 (17%)
Query: 150 DFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLL---QMGANHTSQEIKS 206
D +G TPLH A++ N L VH L+ Q G
Sbjct: 132 DEDGDTPLHIAVVQGN--------------------LPAVHRLVNLFQQGGRELDIYNNL 171
Query: 207 NKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRH 266
+T LHLAV P++V+LL+ + + HG TA H+A A++
Sbjct: 172 RQTPLHLAVITTLPSVVRLLVTAGASPMA----LDRHGQTAAHLACEHRSPTCLRALLDS 227
Query: 267 LLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKR 303
D RN + +H+ E ++ LL+R
Sbjct: 228 AAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLER 264
>gi|117320531 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform a [Homo sapiens]
Length = 900
Score = 101 bits (252), Expect = 7e-22
Identities = 95/276 (34%), Positives = 127/276 (46%), Gaps = 46/276 (16%)
Query: 30 ARAHMLALGPQQLL-AQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRL---DIREHKG 85
A A L G + LL AQDE GDT LHL G V+ + L ++ H
Sbjct: 468 ADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLH 527
Query: 86 KTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVA--ATYGLPGVLLAVLNSG-- 141
+TPL +A Q +V LL +GA+P D G S +H+A A G P +L A+L SG
Sbjct: 528 QTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587
Query: 142 -VQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHT 200
V L DFEGL P+H A+ A + +C+ +L+ GA
Sbjct: 588 AVPQLLHMPDFEGLYPVHLAVRARSP--------------------ECLDLLVDSGAEVE 627
Query: 201 SQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDL--RTFVNMKAHGNTALHMAAALPPGP 258
+ E + +T LHLA + LV L+ R ++ RTF GNT LH+AA L
Sbjct: 628 ATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFA-----GNTPLHLAAGL---- 678
Query: 259 AQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGP 294
+ R LL AGAD + ENE+P L P P P
Sbjct: 679 GYPTLTRLLLKAGAD---IHAENEEP---LCPLPSP 708
>gi|117320540 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 101 bits (252), Expect = 7e-22
Identities = 95/276 (34%), Positives = 127/276 (46%), Gaps = 46/276 (16%)
Query: 30 ARAHMLALGPQQLL-AQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRL---DIREHKG 85
A A L G + LL AQDE GDT LHL G V+ + L ++ H
Sbjct: 468 ADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLH 527
Query: 86 KTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVA--ATYGLPGVLLAVLNSG-- 141
+TPL +A Q +V LL +GA+P D G S +H+A A G P +L A+L SG
Sbjct: 528 QTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587
Query: 142 -VQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHT 200
V L DFEGL P+H A+ A + +C+ +L+ GA
Sbjct: 588 AVPQLLHMPDFEGLYPVHLAVRARSP--------------------ECLDLLVDSGAEVE 627
Query: 201 SQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDL--RTFVNMKAHGNTALHMAAALPPGP 258
+ E + +T LHLA + LV L+ R ++ RTF GNT LH+AA L
Sbjct: 628 ATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFA-----GNTPLHLAAGL---- 678
Query: 259 AQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGP 294
+ R LL AGAD + ENE+P L P P P
Sbjct: 679 GYPTLTRLLLKAGAD---IHAENEEP---LCPLPSP 708
>gi|117320527 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 101 bits (252), Expect = 7e-22
Identities = 95/276 (34%), Positives = 127/276 (46%), Gaps = 46/276 (16%)
Query: 30 ARAHMLALGPQQLL-AQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRL---DIREHKG 85
A A L G + LL AQDE GDT LHL G V+ + L ++ H
Sbjct: 468 ADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLH 527
Query: 86 KTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVA--ATYGLPGVLLAVLNSG-- 141
+TPL +A Q +V LL +GA+P D G S +H+A A G P +L A+L SG
Sbjct: 528 QTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587
Query: 142 -VQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHT 200
V L DFEGL P+H A+ A + +C+ +L+ GA
Sbjct: 588 AVPQLLHMPDFEGLYPVHLAVRARSP--------------------ECLDLLVDSGAEVE 627
Query: 201 SQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDL--RTFVNMKAHGNTALHMAAALPPGP 258
+ E + +T LHLA + LV L+ R ++ RTF GNT LH+AA L
Sbjct: 628 ATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFA-----GNTPLHLAAGL---- 678
Query: 259 AQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGP 294
+ R LL AGAD + ENE+P L P P P
Sbjct: 679 GYPTLTRLLLKAGAD---IHAENEEP---LCPLPSP 708
>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
Length = 969
Score = 89.0 bits (219), Expect = 5e-18
Identities = 80/254 (31%), Positives = 120/254 (47%), Gaps = 37/254 (14%)
Query: 34 MLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRL------DIREHKGKT 87
+LA+ QDE GD++LHL + + ++L+V L ++R +T
Sbjct: 529 LLAVQRHLTAVQDENGDSVLHLAI---IHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
Query: 88 PLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVL-NSGVQVDL 146
PL +A Q +VEDLL GA+ + D G SVLH+AA G VL +L + + L
Sbjct: 586 PLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLL 645
Query: 147 EARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKS 206
+ + +GL +H A+++ + L C+ +L+ GA+ +QE KS
Sbjct: 646 DHPNGDGLNAIHLAMMS--------------------NSLPCLLLLVAAGADVNAQEQKS 685
Query: 207 NKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRH 266
+T LHLAV+ N +L L L GD + G T LH+AA G +
Sbjct: 686 GRTALHLAVEHDNISLAGCL--LLEGDAHV-DSTTYDGTTPLHIAA----GRGSTRLAAL 738
Query: 267 LLAAGADPTLRNLE 280
L AAGADP + N E
Sbjct: 739 LKAAGADPLVENFE 752
Score = 43.1 bits (100), Expect = 3e-04
Identities = 39/121 (32%), Positives = 60/121 (49%), Gaps = 6/121 (4%)
Query: 189 VHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLR-TFVNMKAH-GNT 246
V MLL + + T+ + ++ +VLHLA+ + LV+ LLE+ G + +NM+ T
Sbjct: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
Query: 247 ALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRV 306
LH+A QE +V LL AGAD +L + +HL + L LLK +
Sbjct: 586 PLHLAVI----TKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKA 641
Query: 307 A 307
A
Sbjct: 642 A 642
>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, epsilon [Homo sapiens]
Length = 500
Score = 84.7 bits (208), Expect = 9e-17
Identities = 91/277 (32%), Positives = 121/277 (43%), Gaps = 44/277 (15%)
Query: 23 PGPSLEVARAHMLALGPQQLLAQ---DEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLD 79
P P L + H+ AL PQQL A E+GDTL+HL A L LD
Sbjct: 232 PAPRLPLP--HVGALSPQQLEALTYISEDGDTLVHLAVIHEAP-AVLLCCLALLPQEVLD 288
Query: 80 IREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVA--------ATYGLP 131
I+ + +T L +A +QP V L+ GA D G + LHVA A L
Sbjct: 289 IQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLE 348
Query: 132 GVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHM 191
G + +DL+ ++++GL LH A L N + + +
Sbjct: 349 GRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPL--------------------MEL 388
Query: 192 LLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLEL-PRGDLRTFVNMKAHGNTALHM 250
LL+ GA+ QE S KT LHLAV+ LVQ LL+ + D R +G T LH+
Sbjct: 389 LLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARML-----NGCTPLHL 443
Query: 251 AAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
AA G I L AGAD LRN+E+E P L
Sbjct: 444 AA----GRGLMGISSTLCKAGADSLLRNVEDETPQDL 476
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 76.6 bits (187), Expect = 3e-14
Identities = 71/236 (30%), Positives = 112/236 (47%), Gaps = 43/236 (18%)
Query: 61 LRWAAYAA-AEVLQ--VYRRLDI--REHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAAD 115
L WAA+ EVL+ V R D+ ++ KG L AAA+ Q +V+ LL +GAE + +
Sbjct: 177 LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPN 236
Query: 116 HQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCP 175
G + LH+A G V + ++N+G V+ + D +G TPLH A ++ N A+
Sbjct: 237 AFGNTALHIACYLGQDAVAIELVNAGANVN-QPND-KGFTPLHVAAVSTNGAL------- 287
Query: 176 RVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLL----ELPR 231
C+ +L+ GA+ + + K K+ LH+A T Q+L+ E+
Sbjct: 288 ------------CLELLVNNGAD-VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDC 334
Query: 232 GDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
D GNT LH+AA E ++ L+ GAD R + + P+HL
Sbjct: 335 AD--------KFGNTPLHVAARY----GHELLISTLMTNGADTARRGIHDMFPLHL 378
Score = 62.4 bits (150), Expect = 5e-10
Identities = 64/221 (28%), Positives = 94/221 (42%), Gaps = 36/221 (16%)
Query: 53 LHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPN 112
LHL A G A AE L LD+R+HKG+T L +A VE L GA
Sbjct: 589 LHLAAYNGHCEALKTLAETLV---NLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Query: 113 AADHQGR-SVLHVAATYGLPGVLLAVLNSGVQVDL-EARDFEGLTPLHTAILALNVAMRP 170
+ + + + LH AA G L +++SG + D+ + D G TPL AI+
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIM-------- 697
Query: 171 SDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELP 230
+DCVH+LL+ G+ + +++ + AV L LL
Sbjct: 698 ------------NGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL---- 741
Query: 231 RGDLRTFVNMK-AHGNTALHMAAALPPGPAQEAIVRHLLAA 270
D FV + G T +H+A+A A++R LL A
Sbjct: 742 --DHDAFVLCRDFKGRTPIHLASAC----GHTAVLRTLLQA 776
Score = 58.9 bits (141), Expect = 6e-09
Identities = 75/276 (27%), Positives = 116/276 (42%), Gaps = 30/276 (10%)
Query: 27 LEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGK 86
+EV AH G L+ + + T LH AA G + + + + D+ + G+
Sbjct: 634 VEVLTAH----GASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQ 689
Query: 87 TPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDL 146
TPL++A V LL G+ +AAD +GR+ LH A G L A+L+ V
Sbjct: 690 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV-- 747
Query: 147 EARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKS 206
RDF+G TP+H A + A+ + L LST D LD G ++ S
Sbjct: 748 LCRDFKGRTPIHLASACGHTAVLRT-LLQAALST---DPLDA-------GVDY------S 790
Query: 207 NKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRH 266
+ +H A + ++LLLE F ++ + T LH A E ++
Sbjct: 791 GYSPMHWASYTGHEDCLELLLE-----HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGA 845
Query: 267 LLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLK 302
L A + R+ + P+H GLR LL+
Sbjct: 846 LGAKIVNS--RDAKGRTPLHAAAFADNVSGLRMLLQ 879
Score = 53.9 bits (128), Expect = 2e-07
Identities = 58/210 (27%), Positives = 87/210 (41%), Gaps = 31/210 (14%)
Query: 78 LDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV 137
++ R+ +TPL VAAA E L L + N AD GRS LH A G + +
Sbjct: 100 VNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLL 159
Query: 138 LNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGA 197
LN G L D + PLH A L+ + +L+ GA
Sbjct: 160 LNKG--ASLNVCDKKERQPLHWAAFL--------------------GHLEVLKLLVARGA 197
Query: 198 NHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPG 257
+ ++ + +LH A + +V+ LL + A GNTALH+A L
Sbjct: 198 DLGCKD-RKGYGLLHTAAASGQIEVVKYLLRMG----AEIDEPNAFGNTALHIACYL--- 249
Query: 258 PAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
Q+A+ L+ AGA+ N + P+H+
Sbjct: 250 -GQDAVAIELVNAGANVNQPNDKGFTPLHV 278
Score = 50.4 bits (119), Expect = 2e-06
Identities = 71/287 (24%), Positives = 112/287 (39%), Gaps = 42/287 (14%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVL-QVYRRLDIREHKGKTPLLVAAAANQPLIVED 103
Q +EG + LH+ A G + +++L Q +D + G TPL VAA L++
Sbjct: 302 QSKEGKSPLHMAAIHG----RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357
Query: 104 LLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILA 163
L+ GA+ LH+A +G +L+SG + L+ H
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSI----VSSLSNEHVLSAG 413
Query: 164 LNVAMRPSDLCPRVLSTQAR-DRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTL 222
++ P +L L A ++C+++LL GA+ ++ K +T LH A +
Sbjct: 414 FDI-NTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRD-KFGRTPLHYAAANGSYQC 471
Query: 223 VQLLLELPRGDLRTFVN-MKAHGNTALHMAAA----------------------LPPGPA 259
L+ G VN G + LH AAA L
Sbjct: 472 AVTLVTAGAG-----VNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRR 526
Query: 260 QEAI--VRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRS 304
+EA + LL GADP+LR+ + VH + L LL+ S
Sbjct: 527 KEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS 573
Score = 45.4 bits (106), Expect = 6e-05
Identities = 44/149 (29%), Positives = 65/149 (43%), Gaps = 23/149 (15%)
Query: 81 REHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNS 140
R+ KG+TPL AA A+ + LL AE NA DH GR+ L AA G + +L
Sbjct: 854 RDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYR 913
Query: 141 GVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARD--RLDCVHMLLQMGAN 198
G + DL D T LH A + + C ++ + +D ++ + LQM
Sbjct: 914 G-KADLTVLDENKNTALHLA------CSKGHEKCALMILAETQDLGLINATNSALQM--- 963
Query: 199 HTSQEIKSNKTVLHLAVQAANPTLVQLLL 227
LH+A + ++VQ LL
Sbjct: 964 -----------PLHIAARNGLASVVQALL 981
Score = 43.9 bits (102), Expect = 2e-04
Identities = 60/228 (26%), Positives = 95/228 (41%), Gaps = 24/228 (10%)
Query: 88 PLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLE 147
PL+ A + V LL+ N D + R+ LH AA G +L +L SG V+
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN-- 68
Query: 148 ARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRL--DCVHMLLQMGANHTSQEI- 204
A+D LTPLH A + N + L ARD+L +H+ A ++ +
Sbjct: 69 AKDTLWLTPLHRAAASRNEKVL-GLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127
Query: 205 ----------KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAAL 254
+S ++ LH AV + + V LLL +G + K LH AA L
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN--KGASLNVCDKKE--RQPLHWAAFL 183
Query: 255 PPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLK 302
+++ L+A GAD ++ + +H E ++ LL+
Sbjct: 184 ----GHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
Score = 42.7 bits (99), Expect = 4e-04
Identities = 64/267 (23%), Positives = 99/267 (37%), Gaps = 32/267 (11%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDL 104
+D +G T +H AA G R E + D+ +PL +AA ++ L
Sbjct: 546 RDRQGYTAVHYAAAYGNRQNLELLLE-MSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL 604
Query: 105 LNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILAL 164
+ DH+GR+ L +A G + + G ++ R TPLH A
Sbjct: 605 AETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK-RKWTPLHAA---- 659
Query: 165 NVAMRPSDLCPRVLSTQARDRLDCVHMLLQMG--ANHTSQEIKSNKTVLHLAVQAANPTL 222
A D +H+L+ G A+ T +T L LA+ +
Sbjct: 660 ----------------AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDC 703
Query: 223 VQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENE 282
V LLLE +G +++ G TALH A A++ H A R+ +
Sbjct: 704 VHLLLE--KGSTADAADLR--GRTALHRGAVTGCEDCLAALLDH----DAFVLCRDFKGR 755
Query: 283 QPVHLLRPGPGPEGLRQLLKRSRVAPP 309
P+HL LR LL+ + P
Sbjct: 756 TPIHLASACGHTAVLRTLLQAALSTDP 782
Score = 32.7 bits (73), Expect = 0.43
Identities = 24/87 (27%), Positives = 37/87 (42%)
Query: 34 MLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAA 93
+L G L DE +T LHL ++G A Q ++ + PL +AA
Sbjct: 910 LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
Query: 94 AANQPLIVEDLLNLGAEPNAADHQGRS 120
+V+ LL+ GA A D +G +
Sbjct: 970 RNGLASVVQALLSHGATVLAVDEEGHT 996
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 73.6 bits (179), Expect = 2e-13
Identities = 68/248 (27%), Positives = 109/248 (43%), Gaps = 35/248 (14%)
Query: 59 RGLRWAAY-----AAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNA 113
R L WAAY A ++ + ++ KG TPL AA+ Q +V+ LLNLG E +
Sbjct: 150 RALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDE 209
Query: 114 ADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDL 173
+ G + LH+A G V+ +++ G V+ + G TPLH A + + A+
Sbjct: 210 INVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN--GFTPLHFAAASTHGAL----- 262
Query: 174 CPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGD 233
C+ +L+ GA+ Q K K+ LH+ T Q L++ G+
Sbjct: 263 --------------CLELLVNNGADVNIQS-KDGKSPLHMTAVHGRFTRSQTLIQ-NGGE 306
Query: 234 LRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPG 293
+ + GNT LH+AA E ++ L +GAD + + P+HL
Sbjct: 307 IDC---VDKDGNTPLHVAARY----GHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
Query: 294 PEGLRQLL 301
+ R+LL
Sbjct: 360 SDCCRKLL 367
Score = 65.5 bits (158), Expect = 6e-11
Identities = 67/245 (27%), Positives = 105/245 (42%), Gaps = 35/245 (14%)
Query: 44 AQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVED 103
A+D+ T LH+ AA A A ++ + +++ + G+T L AA +V
Sbjct: 77 ARDKNWQTPLHVAAANK---AVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNL 133
Query: 104 LLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILA 163
LL GA NA D + R LH AA G V+ ++N G +V +D +G TPLH A
Sbjct: 134 LLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEV--TCKDKKGYTPLHAA--- 188
Query: 164 LNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLV 223
+ +++ V LL +G + N T LH+A +V
Sbjct: 189 -----------------ASNGQINVVKHLLNLGVEIDEINVYGN-TALHIACYNGQDAVV 230
Query: 224 QLLLELPRGDLRTFVNM-KAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENE 282
L+ D VN +G T LH AAA G + L+ GAD +++ + +
Sbjct: 231 NELI-----DYGANVNQPNNNGFTPLHFAAASTHG---ALCLELLVNNGADVNIQSKDGK 282
Query: 283 QPVHL 287
P+H+
Sbjct: 283 SPLHM 287
Score = 57.4 bits (137), Expect = 2e-08
Identities = 66/218 (30%), Positives = 101/218 (46%), Gaps = 30/218 (13%)
Query: 86 KTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVA-ATYGLPGVLLAVLNSGVQV 144
+TPL VAA I+E L+ GA NA D+ + LH A A+ V + + +S
Sbjct: 17 RTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS---A 73
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSD-LCPRVLSTQARDR--------------LDCV 189
D+ ARD TPLH A A N A++ ++ + P + S DR ++ V
Sbjct: 74 DVNARDKNWQTPLHVA--AANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMV 131
Query: 190 HMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALH 249
++LL GAN + + K ++ LH A + +V LL+ G T + K G T LH
Sbjct: 132 NLLLAKGANINAFD-KKDRRALHWAAYMGHLDVVALLIN--HGAEVTCKDKK--GYTPLH 186
Query: 250 MAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
AA+ Q +V+HLL G + N+ +H+
Sbjct: 187 AAAS----NGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Score = 57.0 bits (136), Expect = 2e-08
Identities = 70/257 (27%), Positives = 106/257 (41%), Gaps = 42/257 (16%)
Query: 34 MLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRR----LDIREHKGKTPL 89
+L L ++ A+D T LH R A + E +QV + ++ R+ +TPL
Sbjct: 34 LLILSGARVNAKDNMWLTPLH-------RAVASRSEEAVQVLIKHSADVNARDKNWQTPL 86
Query: 90 LVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEAR 149
VAAA E ++ L + N +D GR+ LH AA G ++ +L G ++ A
Sbjct: 87 HVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANIN--AF 144
Query: 150 DFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKT 209
D + LH A LD V +L+ GA T ++ K T
Sbjct: 145 DKKDRRALHWAAY--------------------MGHLDVVALLINHGAEVTCKD-KKGYT 183
Query: 210 VLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLA 269
LH A +V+ LL L + +GNTALH+A Q+A+V L+
Sbjct: 184 PLHAAASNGQINVVKHLLNLG----VEIDEINVYGNTALHIACY----NGQDAVVNELID 235
Query: 270 AGADPTLRNLENEQPVH 286
GA+ N P+H
Sbjct: 236 YGANVNQPNNNGFTPLH 252
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/80 (40%), Positives = 46/80 (57%), Gaps = 1/80 (1%)
Query: 81 REHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNS 140
R+ KG+TPL AA A+ ++ LL A NA D+ G++ L +AA G G + ++NS
Sbjct: 810 RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
Query: 141 GVQVDLEARDFEGLTPLHTA 160
Q DL +D + TPLH A
Sbjct: 870 -AQADLTVKDKDLNTPLHLA 888
Score = 48.9 bits (115), Expect = 6e-06
Identities = 54/209 (25%), Positives = 82/209 (39%), Gaps = 30/209 (14%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDL 104
Q ++G + LH+ A G + ++Q +D + G TPL VAA L++ L
Sbjct: 277 QSKDGKSPLHMTAVHG---RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333
Query: 105 LNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILAL 164
GA+ LH+AA +L+SG ++D D G T LH A
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID--TPDKFGRTCLHAAAAGG 391
Query: 165 NVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQ 224
NV +C+ +L GA+ ++ K +T LH A + ++
Sbjct: 392 NV--------------------ECIKLLQSSGADFHKKD-KCGRTPLHYAAANCHFHCIE 430
Query: 225 LLLELPRGDLRTFVNMKAHGNTALHMAAA 253
L+ T G TALH AAA
Sbjct: 431 TLVTTGANVNET----DDWGRTALHYAAA 455
Score = 45.8 bits (107), Expect = 5e-05
Identities = 47/180 (26%), Positives = 68/180 (37%), Gaps = 24/180 (13%)
Query: 51 TLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAE 110
T LH G E+ +D+++ KG+TPL++A A V LL A
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 111 PNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRP 170
+ D G + LH G + +L +V + +D G TPLH A
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQ--EVSILCKDSRGRTPLHYA---------- 718
Query: 171 SDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNK--TVLHLAVQAANPTLVQLLLE 228
AR + LLQM + K N+ T LH A N +++LLE
Sbjct: 719 ----------AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
Score = 43.5 bits (101), Expect = 2e-04
Identities = 65/232 (28%), Positives = 100/232 (43%), Gaps = 44/232 (18%)
Query: 46 DEEGDTLLHLFAA------RGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPL 99
D+ G T LH AA + + A+ +E L+ R L +E L
Sbjct: 443 DDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE--------------ATL 488
Query: 100 IVEDLLNLGAEPNAADHQGRSVLHVAATYG---LPGVLLAVLNSGVQVDLEARDFEGLTP 156
+E LL A P+ D +G + +H AA YG +LL NSG + E+ +P
Sbjct: 489 CLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFE---ESDSGATKSP 545
Query: 157 LHTAIL-----ALNVAMRPSDLCPRVLSTQARDRLD---------CVHMLLQMGANHTSQ 202
LH A AL V ++ S + + + R LD CV L+ GA+ +
Sbjct: 546 LHLAAYNGHHQALEVLLQ-SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK 604
Query: 203 EIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMK-AHGNTALHMAAA 253
+ + +T LH +V + ++LLLE+ D V++K A G T L +A A
Sbjct: 605 DNVTKRTPLHASVINGHTLCLRLLLEI--ADNPEAVDVKDAKGQTPLMLAVA 654
Score = 41.2 bits (95), Expect = 0.001
Identities = 66/254 (25%), Positives = 103/254 (40%), Gaps = 29/254 (11%)
Query: 46 DEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHK----GKTPLLVAAAANQPLIV 101
D+ G T LH AA G E +++ + HK G+TPL AAA +
Sbjct: 377 DKFGRTCLHAAAAGG-------NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCI 429
Query: 102 EDLLNLGAEPNAADHQGRSVLHVAATYGLP--GVLLAVLNSGVQVDLEARDF-EGLTPLH 158
E L+ GA N D GR+ LH AA + +L + + AR+ E L
Sbjct: 430 ETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLC 489
Query: 159 TAILALNVA---MRPSDLCPRVLSTQARDRLDCVHMLLQ-MGANHTSQEIKSNKTVLHLA 214
L N A +R + + A C+ +LL+ + + + K+ LHLA
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549
Query: 215 VQAANPTLVQLLLE-LPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGAD 273
+ +++LL+ L D+R G TAL +AA EA++ GA
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIR-----DEKGRTALDLAAFKGHTECVEALIN----PGAS 600
Query: 274 PTLR-NLENEQPVH 286
++ N+ P+H
Sbjct: 601 IFVKDNVTKRTPLH 614
Score = 39.3 bits (90), Expect = 0.005
Identities = 55/218 (25%), Positives = 88/218 (40%), Gaps = 37/218 (16%)
Query: 42 LLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLD---IREHKGKTPLLVAAAANQP 98
+L +D G T LH AARG A +E+LQ+ + ++++G TPL A
Sbjct: 704 ILCKDSRGRTPLHYAAARG---HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760
Query: 99 LIVEDLLNLGAEPNAADHQGRSVLHVAATY---GLPGVLLAVLNSGVQVDLEARDFEGLT 155
+E LL + + LH A +LL ++S + + RD +G T
Sbjct: 761 NCIEVLLEQKCFRKFIGNP-FTPLHCAIINDHGNCASLLLGAIDSSI---VSCRDDKGRT 816
Query: 156 PLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAV 215
PL A A D ++C+ +LL+ A + + S KT L +A
Sbjct: 817 PLRAAAFA--------------------DHVECLQLLLRHSAPVNAVD-NSGKTALMMAA 855
Query: 216 QAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAA 253
+ V +L+ + DL NT LH+A +
Sbjct: 856 ENGQAGAVDILVNSAQADLTV---KDKDLNTPLHLACS 890
>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, alpha [Homo sapiens]
Length = 317
Score = 69.3 bits (168), Expect = 4e-12
Identities = 59/193 (30%), Positives = 88/193 (45%), Gaps = 37/193 (19%)
Query: 47 EEGDTLLHLFAARGLRWAAYAAAEVLQVYRR-------LDIREHKGKTPLLVAAAANQPL 99
E+GD+ LHL + A ++V R+ L+ + + +TPL +A NQP
Sbjct: 72 EDGDSFLHLAIIHEEK------ALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPE 125
Query: 100 IVEDLLNLGAEPNAADHQGRSVLHVAATYGL---PGVLL-AVLNSGVQVDLEARDFEGLT 155
I E LL G +P D +G + LH+A G GVL + + L+A ++ G T
Sbjct: 126 IAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHT 185
Query: 156 PLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAV 215
LH A + L V +L+ +GA+ +QE + +T LHLAV
Sbjct: 186 CLHLASI--------------------HGYLGIVELLVSLGADVNAQEPCNGRTALHLAV 225
Query: 216 QAANPTLVQLLLE 228
NP LV LLL+
Sbjct: 226 DLQNPDLVSLLLK 238
Score = 38.9 bits (89), Expect = 0.006
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 6/87 (6%)
Query: 202 QEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAALPPGPAQ 260
Q + + LHLA+ L ++ +GDL F+N + + T LH+A Q
Sbjct: 69 QLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDL-AFLNFQNNLQQTPLHLAVITN----Q 123
Query: 261 EAIVRHLLAAGADPTLRNLENEQPVHL 287
I LL AG DP LR+ P+HL
Sbjct: 124 PEIAEALLGAGCDPELRDFRGNTPLHL 150
Score = 37.4 bits (85), Expect = 0.017
Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 14/120 (11%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVL-------QVYRRLDIREHKGKTPLLVAAAANQ 97
+D G+T LHL +G A+ VL ++ L + G T L +A+
Sbjct: 140 RDFRGNTPLHLACEQG----CLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGY 195
Query: 98 PLIVEDLLNLGAEPNAADH-QGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTP 156
IVE L++LGA+ NA + GR+ LH+A P ++ +L G D+ ++G +P
Sbjct: 196 LGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG--ADVNRVTYQGYSP 253
Score = 32.0 bits (71), Expect = 0.73
Identities = 29/93 (31%), Positives = 40/93 (43%), Gaps = 10/93 (10%)
Query: 42 LLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHK---GKTPLLVAAAANQP 98
L A + G T LHL + G Y L V D+ + G+T L +A P
Sbjct: 176 LKATNYNGHTCLHLASIHG-----YLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNP 230
Query: 99 LIVEDLLNLGAEPNAADHQGRSVLHVAATYGLP 131
+V LL GA+ N +QG S + T+G P
Sbjct: 231 DLVSLLLKCGADVNRVTYQGYSPYQL--TWGRP 261
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 69.3 bits (168), Expect = 4e-12
Identities = 70/225 (31%), Positives = 102/225 (45%), Gaps = 28/225 (12%)
Query: 78 LDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV 137
+D + G TPLL+AA QP + LL GA+ N D G + LH AA G G +
Sbjct: 388 VDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL 447
Query: 138 LNSGVQVDLEARDFEGLTPLHTAI------LALNVAMRPSDLCPRVLSTQARDRL----- 186
L+ G VD + R EG TPLH A +A + R +D P + + + L
Sbjct: 448 LDHGACVDAQER--EGWTPLHLAAQNNFENVARLLVSRQAD--PNLHEAEGKTPLHVAAY 503
Query: 187 ----DCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKA 242
V +L GA +Q+ ++ +T LHLAV+ +Q LL+ G + ++
Sbjct: 504 FGHVSLVKLLTSQGAELDAQQ-RNLRTPLHLAVERGKVRAIQHLLK--SGAVPDALDQSG 560
Query: 243 HGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
+G LH AAA + I + LL GA L + P+HL
Sbjct: 561 YG--PLHTAAA----RGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/262 (29%), Positives = 106/262 (40%), Gaps = 40/262 (15%)
Query: 29 VARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTP 88
V+ +L +L AQ T LHL RG A +L+ D + G P
Sbjct: 507 VSLVKLLTSQGAELDAQQRNLRTPLHLAVERG---KVRAIQHLLKSGAVPDALDQSGYGP 563
Query: 89 LLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEA 148
L AAA + LI + LL GA HQG + LH+AA G ++ + S ++ A
Sbjct: 564 LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAES--HANMGA 621
Query: 149 RDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNK 208
TPLH A A+ V LLQ GA+ + E +S
Sbjct: 622 LGAVNWTPLHLAARHGEEAV--------------------VSALLQCGADPNAAE-QSGW 660
Query: 209 TVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH---GNTALHMAAALPPGPAQEAIVR 265
T LHLAVQ + V LLE N+ A G T H+AA AI++
Sbjct: 661 TPLHLAVQRSTFLSVINLLE-------HHANVHARNKVGWTPAHLAAL----KGNTAILK 709
Query: 266 HLLAAGADPTLRNLENEQPVHL 287
L+ AGA +++ + P+ L
Sbjct: 710 VLVEAGAQLDVQDGVSCTPLQL 731
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 69.3 bits (168), Expect = 4e-12
Identities = 66/252 (26%), Positives = 114/252 (45%), Gaps = 43/252 (17%)
Query: 59 RGLRWAAYAA-AEVLQVY----RRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNA 113
R + WAAY EV+++ + ++ K TPL AA++ +V+ LL+LG + N
Sbjct: 175 RAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNE 234
Query: 114 ADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDL 173
+ G + LHVA G V+ +++ G V+ ++ +G TPLH A + + A+
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVN--QKNEKGFTPLHFAAASTHGAL----- 287
Query: 174 CPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQ----AANPTLVQLLLEL 229
C+ +L+ GA+ + + K KT LH+ + + T++Q +
Sbjct: 288 --------------CLELLVGNGAD-VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 332
Query: 230 PRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLR 289
D +GNT LH+AA E ++ L+ +GAD R + P+HL
Sbjct: 333 DCED--------KNGNTPLHIAARY----GHELLINTLITSGADTAKRGIHGMFPLHLAA 380
Query: 290 PGPGPEGLRQLL 301
+ R+LL
Sbjct: 381 LSGFSDCCRKLL 392
Score = 63.2 bits (152), Expect = 3e-10
Identities = 62/242 (25%), Positives = 103/242 (42%), Gaps = 33/242 (13%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDL 104
+ ++G T LH+ A G R++ + ++Q +D + G TPL +AA L++ L
Sbjct: 302 KSKDGKTPLHMTALHG-RFSR--SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Query: 105 LNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILAL 164
+ GA+ G LH+AA G +L+SG D++ D G T LH A
Sbjct: 359 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSG--FDIDTPDDFGRTCLHAA---- 412
Query: 165 NVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQ 224
A L+C+++LL GA+ ++ K ++ LH A N +
Sbjct: 413 ----------------AAGGNLECLNLLLNTGADFNKKD-KFGRSPLHYAAANCNYQCLF 455
Query: 225 LLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQP 284
L+ G + ++ G T LH AA + +LL A+P +R+ +
Sbjct: 456 ALV----GSGASVNDLDERGCTPLHYAAT---SDTDGKCLEYLLRNDANPGIRDKQGYNA 508
Query: 285 VH 286
VH
Sbjct: 509 VH 510
Score = 58.9 bits (141), Expect = 6e-09
Identities = 68/258 (26%), Positives = 113/258 (43%), Gaps = 44/258 (17%)
Query: 34 MLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRR----LDIREHKGKTPL 89
+L L ++ A+D + T LH R A + E +QV + ++ R+ +TPL
Sbjct: 59 LLILSGARVNAKDSKWLTPLH-------RAVASCSEEAVQVLLKHSADVNARDKNWQTPL 111
Query: 90 LVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEAR 149
+AAA E L+ L + N +D GR+ LH AA G ++ +L+ G ++ A
Sbjct: 112 HIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN--AF 169
Query: 150 DFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKT 209
D + +H A ++ V +L+ GA T ++ K + T
Sbjct: 170 DKKDRRAIHWAAY--------------------MGHIEVVKLLVSHGAEVTCKD-KKSYT 208
Query: 210 VLHLAVQAANPTLVQLLLELPRGDLRTFVN-MKAHGNTALHMAAALPPGPAQEAIVRHLL 268
LH A + ++V+ LL DL +N A+GNT LH+A Q+ +V L+
Sbjct: 209 PLHAAASSGMISVVKYLL-----DLGVDMNEPNAYGNTPLHVACY----NGQDVVVNELI 259
Query: 269 AAGADPTLRNLENEQPVH 286
GA +N + P+H
Sbjct: 260 DCGAIVNQKNEKGFTPLH 277
Score = 58.2 bits (139), Expect = 9e-09
Identities = 66/237 (27%), Positives = 100/237 (42%), Gaps = 32/237 (13%)
Query: 53 LHLFAARGLRWAAYAAAEVL-QVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEP 111
LHL A G + A EVL Q LD+R G+TPL +AA V+ L+N GA
Sbjct: 554 LHLAAYHG----HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
Query: 112 NAADH-QGRSVLHVAATYGLPGVL-LAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMR 169
D+ R+ +H AAT G L L + N+ Q ++ +D G TPL ++L
Sbjct: 610 LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVL------- 662
Query: 170 PSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLEL 229
DCV+ LL GAN +++ K +T LH + V LL+
Sbjct: 663 -------------NGHTDCVYSLLNKGANVDAKD-KWGRTALHRGAVTGHEECVDALLQH 708
Query: 230 PRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVH 286
L + G T +H++AA A+++ + A+P + +H
Sbjct: 709 GAKCLL----RDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALH 761
Score = 56.6 bits (135), Expect = 3e-08
Identities = 62/231 (26%), Positives = 106/231 (45%), Gaps = 30/231 (12%)
Query: 74 VYRRLDI--REHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLP 131
++++ D+ ++++ +TPL AA I+E L+ GA NA D + + LH A
Sbjct: 28 IFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSE 87
Query: 132 GVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSD-LCPRVLSTQARDRL---- 186
+ +L D+ ARD TPLH I A N A++ ++ L P + + DR
Sbjct: 88 EAVQVLLKH--SADVNARDKNWQTPLH--IAAANKAVKCAEALVPLLSNVNVSDRAGRTA 143
Query: 187 ----------DCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRT 236
+ V +LL GAN + + K ++ +H A + +V+LL+ G T
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFD-KKDRRAIHWAAYMGHIEVVKLLVS--HGAEVT 200
Query: 237 FVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
+ K++ T LH AA+ ++V++LL G D N P+H+
Sbjct: 201 CKDKKSY--TPLHAAAS----SGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Score = 53.9 bits (128), Expect = 2e-07
Identities = 58/209 (27%), Positives = 89/209 (42%), Gaps = 26/209 (12%)
Query: 78 LDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV 137
+DI++ G+TPL+++ V LLN GA +A D GR+ LH A G + A+
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 138 LNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGA 197
L G + L RD G TP+H L+ A + +L + A M A
Sbjct: 706 LQHGAKCLL--RDSRGRTPIH-----LSAACGHIGVLGALLQSAA-----------SMDA 747
Query: 198 NHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPG 257
N + + T LH A + T V+LLLE F + + + LH A
Sbjct: 748 NPATAD-NHGYTALHWACYNGHETCVELLLE-----QEVFQKTEGNAFSPLHCAVINDNE 801
Query: 258 PAQEAIVRHLLAAGADPTLRNLENEQPVH 286
A E ++ L A+ + T + + P+H
Sbjct: 802 GAAEMLIDTLGASIVNAT--DSKGRTPLH 828
Score = 46.6 bits (109), Expect = 3e-05
Identities = 71/279 (25%), Positives = 109/279 (39%), Gaps = 59/279 (21%)
Query: 44 AQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVED 103
A+D+ G T LH A G A +LQ + +R+ +G+TP+ ++AA ++
Sbjct: 681 AKDKWGRTALHRGAVTGHEECVDA---LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 737
Query: 104 LL----NLGAEPNAADHQGRSVLHVAATYG----------------LPGVLLAVLNSGVQ 143
LL ++ A P AD+ G + LH A G G + L+ V
Sbjct: 738 LLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVI 797
Query: 144 VDLE----------------ARDFEGLTPLHTA-----------ILALNVAMRPSDLCPR 176
D E A D +G TPLH A +L+ N + D +
Sbjct: 798 NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGK 857
Query: 177 VLSTQARD--RLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDL 234
A + + + V ML+ + + + S T LHLA + T L+LE +
Sbjct: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILE--KITD 915
Query: 235 RTFVN-MKAHGNTALHMAAALPPGPAQEAIVRHLLAAGA 272
R +N A T LH+AA +V+ LL GA
Sbjct: 916 RNLINATNAALQTPLHVAAR----NGLTMVVQELLGKGA 950
Score = 43.1 bits (100), Expect = 3e-04
Identities = 63/263 (23%), Positives = 106/263 (40%), Gaps = 62/263 (23%)
Query: 82 EHKGKTPLLVAAAANQP-LIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLN- 139
+ +G TPL AA ++ +E LL A P D QG + +H +A YG L + +
Sbjct: 468 DERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASE 527
Query: 140 ---------SGVQVDLEARDFEGLTPLHTAIL-----ALNVAMRPSDLCPRVLSTQARDR 185
SG + ++ + ++PLH A AL V ++ S L V ++ R
Sbjct: 528 TPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQ-SLLDLDVRNSSGRTP 586
Query: 186 LD---------CVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLL--------- 227
LD CV +L+ GA+ ++ +T +H A + ++LL+
Sbjct: 587 LDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAV 646
Query: 228 ELPRGDLRT----------------FVNMKAH-------GNTALHMAAALPPGPAQEAIV 264
++ G+ +T +N A+ G TALH A +A++
Sbjct: 647 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL 706
Query: 265 RHLLAAGADPTLRNLENEQPVHL 287
+H GA LR+ P+HL
Sbjct: 707 QH----GAKCLLRDSRGRTPIHL 725
Score = 38.5 bits (88), Expect = 0.008
Identities = 24/78 (30%), Positives = 37/78 (47%)
Query: 41 QLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLI 100
+L QD +T LHL ++G +A E + ++ +TPL VAA ++
Sbjct: 882 ELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMV 941
Query: 101 VEDLLNLGAEPNAADHQG 118
V++LL GA A D G
Sbjct: 942 VQELLGKGASVLAVDENG 959
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 68.6 bits (166), Expect = 7e-12
Identities = 75/281 (26%), Positives = 121/281 (43%), Gaps = 57/281 (20%)
Query: 68 AAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAAT 127
AA +LQ D+ G TPL +AA + + LLN GA N G + LH+A+
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 281
Query: 128 YGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNV--------------AMRPSDL 173
G ++ +L+ G Q++ + +D LTPLH A +V A + L
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 339
Query: 174 CPRVLSTQARDRLDCVHMLLQMGA--------------------NHTSQEIKSNK----- 208
P ++ Q D LDCV +LLQ A +H ++ +K
Sbjct: 340 SPIHMAAQG-DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398
Query: 209 -------TVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQE 261
T LH+A + + +++LLL+ + + G T LH+A+ + P
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLLKTG----ASIDAVTESGLTPLHVASFMGHLP--- 451
Query: 262 AIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLK 302
IV++LL GA P + N++ E P+H+ E + LL+
Sbjct: 452 -IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 491
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/238 (28%), Positives = 101/238 (42%), Gaps = 34/238 (14%)
Query: 50 DTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGA 109
+T LH+ A G A +LQ +++ + +TPL AA +V+ LL A
Sbjct: 471 ETPLHMAARAG---HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 527
Query: 110 EPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMR 169
PN A G + LH+AA G +LA+L + +G TPLH A
Sbjct: 528 NPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFTPLHVA--------- 576
Query: 170 PSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLEL 229
++ +LL+ A H + K+ T LH+AV N +V+LL L
Sbjct: 577 -----------AKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLL--L 622
Query: 230 PRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
PRG + + +G T LH+AA Q + R LL G +++ P+HL
Sbjct: 623 PRGG--SPHSPAWNGYTPLHIAAK----QNQVEVARSLLQYGGSANAESVQGVTPLHL 674
Score = 59.3 bits (142), Expect = 4e-09
Identities = 70/250 (28%), Positives = 104/250 (41%), Gaps = 23/250 (9%)
Query: 46 DEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLL 105
++ G LHL + G E+L L+ KG T L +AA A Q +V +L+
Sbjct: 75 NQNGLNGLHLASKEG---HVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 131
Query: 106 NLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPL-------H 158
N GA NA +G + L++AA V+ +L +G ++ D G TPL H
Sbjct: 132 NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED--GFTPLAVALQQGH 189
Query: 159 TAILA--LNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQ 216
++A +N + P + D +LLQ N K+ T LH+A
Sbjct: 190 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS-KTGFTPLHIAAH 248
Query: 217 AANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTL 276
N + QLLL RG F +G T LH+A+ +VR LL GA
Sbjct: 249 YENLNVAQLLLN--RGASVNFT--PQNGITPLHIASR----RGNVIMVRLLLDRGAQIET 300
Query: 277 RNLENEQPVH 286
+ + P+H
Sbjct: 301 KTKDELTPLH 310
Score = 47.0 bits (110), Expect = 2e-05
Identities = 56/206 (27%), Positives = 82/206 (39%), Gaps = 33/206 (16%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +AA NQ + LL G NA QG + LH+AA G ++ +L+
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI 204
+L + GLTPLH +V + +L++ G
Sbjct: 695 NLGNK--SGLTPLHLVAQEGHVPV--------------------ADVLIKHGV-MVDATT 731
Query: 205 KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAALPPGPAQEAI 263
+ T LH+A N LV+ LL+ + VN K G + LH AA I
Sbjct: 732 RMGYTPLHVASHYGNIKLVKFLLQ-----HQADVNAKTKLGYSPLHQAAQ----QGHTDI 782
Query: 264 VRHLLAAGADPTLRNLENEQPVHLLR 289
V LL GA P + + P+ + +
Sbjct: 783 VTLLLKNGASPNEVSSDGTTPLAIAK 808
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 68.6 bits (166), Expect = 7e-12
Identities = 75/281 (26%), Positives = 121/281 (43%), Gaps = 57/281 (20%)
Query: 68 AAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAAT 127
AA +LQ D+ G TPL +AA + + LLN GA N G + LH+A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 128 YGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNV--------------AMRPSDL 173
G ++ +L+ G Q++ + +D LTPLH A +V A + L
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Query: 174 CPRVLSTQARDRLDCVHMLLQMGA--------------------NHTSQEIKSNK----- 208
P ++ Q D LDCV +LLQ A +H ++ +K
Sbjct: 307 SPIHMAAQG-DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 209 -------TVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQE 261
T LH+A + + +++LLL+ + + G T LH+A+ + P
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTG----ASIDAVTESGLTPLHVASFMGHLP--- 418
Query: 262 AIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLK 302
IV++LL GA P + N++ E P+H+ E + LL+
Sbjct: 419 -IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/238 (28%), Positives = 101/238 (42%), Gaps = 34/238 (14%)
Query: 50 DTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGA 109
+T LH+ A G A +LQ +++ + +TPL AA +V+ LL A
Sbjct: 438 ETPLHMAARAG---HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 110 EPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMR 169
PN A G + LH+AA G +LA+L + +G TPLH A
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFTPLHVA--------- 543
Query: 170 PSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLEL 229
++ +LL+ A H + K+ T LH+AV N +V+LL L
Sbjct: 544 -----------AKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLL--L 589
Query: 230 PRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
PRG + + +G T LH+AA Q + R LL G +++ P+HL
Sbjct: 590 PRGG--SPHSPAWNGYTPLHIAAK----QNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Score = 59.3 bits (142), Expect = 4e-09
Identities = 70/250 (28%), Positives = 104/250 (41%), Gaps = 23/250 (9%)
Query: 46 DEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLL 105
++ G LHL + G E+L L+ KG T L +AA A Q +V +L+
Sbjct: 42 NQNGLNGLHLASKEG---HVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 106 NLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPL-------H 158
N GA NA +G + L++AA V+ +L +G ++ D G TPL H
Sbjct: 99 NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED--GFTPLAVALQQGH 156
Query: 159 TAILA--LNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQ 216
++A +N + P + D +LLQ N K+ T LH+A
Sbjct: 157 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS-KTGFTPLHIAAH 215
Query: 217 AANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTL 276
N + QLLL RG F +G T LH+A+ +VR LL GA
Sbjct: 216 YENLNVAQLLLN--RGASVNFT--PQNGITPLHIASR----RGNVIMVRLLLDRGAQIET 267
Query: 277 RNLENEQPVH 286
+ + P+H
Sbjct: 268 KTKDELTPLH 277
Score = 47.0 bits (110), Expect = 2e-05
Identities = 56/206 (27%), Positives = 82/206 (39%), Gaps = 33/206 (16%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +AA NQ + LL G NA QG + LH+AA G ++ +L+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI 204
+L + GLTPLH +V + +L++ G
Sbjct: 662 NLGNK--SGLTPLHLVAQEGHVPV--------------------ADVLIKHGV-MVDATT 698
Query: 205 KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAALPPGPAQEAI 263
+ T LH+A N LV+ LL+ + VN K G + LH AA I
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQ-----HQADVNAKTKLGYSPLHQAAQ----QGHTDI 749
Query: 264 VRHLLAAGADPTLRNLENEQPVHLLR 289
V LL GA P + + P+ + +
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAK 775
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 68.6 bits (166), Expect = 7e-12
Identities = 75/281 (26%), Positives = 121/281 (43%), Gaps = 57/281 (20%)
Query: 68 AAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAAT 127
AA +LQ D+ G TPL +AA + + LLN GA N G + LH+A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 128 YGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNV--------------AMRPSDL 173
G ++ +L+ G Q++ + +D LTPLH A +V A + L
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Query: 174 CPRVLSTQARDRLDCVHMLLQMGA--------------------NHTSQEIKSNK----- 208
P ++ Q D LDCV +LLQ A +H ++ +K
Sbjct: 307 SPIHMAAQG-DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 209 -------TVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQE 261
T LH+A + + +++LLL+ + + G T LH+A+ + P
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTG----ASIDAVTESGLTPLHVASFMGHLP--- 418
Query: 262 AIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLK 302
IV++LL GA P + N++ E P+H+ E + LL+
Sbjct: 419 -IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/238 (28%), Positives = 101/238 (42%), Gaps = 34/238 (14%)
Query: 50 DTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGA 109
+T LH+ A G A +LQ +++ + +TPL AA +V+ LL A
Sbjct: 438 ETPLHMAARAG---HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 110 EPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMR 169
PN A G + LH+AA G +LA+L + +G TPLH A
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFTPLHVA--------- 543
Query: 170 PSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLEL 229
++ +LL+ A H + K+ T LH+AV N +V+LL L
Sbjct: 544 -----------AKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLL--L 589
Query: 230 PRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
PRG + + +G T LH+AA Q + R LL G +++ P+HL
Sbjct: 590 PRGG--SPHSPAWNGYTPLHIAAK----QNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Score = 59.3 bits (142), Expect = 4e-09
Identities = 70/250 (28%), Positives = 104/250 (41%), Gaps = 23/250 (9%)
Query: 46 DEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLL 105
++ G LHL + G E+L L+ KG T L +AA A Q +V +L+
Sbjct: 42 NQNGLNGLHLASKEG---HVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 106 NLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPL-------H 158
N GA NA +G + L++AA V+ +L +G ++ D G TPL H
Sbjct: 99 NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED--GFTPLAVALQQGH 156
Query: 159 TAILA--LNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQ 216
++A +N + P + D +LLQ N K+ T LH+A
Sbjct: 157 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS-KTGFTPLHIAAH 215
Query: 217 AANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTL 276
N + QLLL RG F +G T LH+A+ +VR LL GA
Sbjct: 216 YENLNVAQLLLN--RGASVNFT--PQNGITPLHIASR----RGNVIMVRLLLDRGAQIET 267
Query: 277 RNLENEQPVH 286
+ + P+H
Sbjct: 268 KTKDELTPLH 277
Score = 47.0 bits (110), Expect = 2e-05
Identities = 56/206 (27%), Positives = 82/206 (39%), Gaps = 33/206 (16%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +AA NQ + LL G NA QG + LH+AA G ++ +L+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI 204
+L + GLTPLH +V + +L++ G
Sbjct: 662 NLGNK--SGLTPLHLVAQEGHVPV--------------------ADVLIKHGV-MVDATT 698
Query: 205 KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAALPPGPAQEAI 263
+ T LH+A N LV+ LL+ + VN K G + LH AA I
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQ-----HQADVNAKTKLGYSPLHQAAQ----QGHTDI 749
Query: 264 VRHLLAAGADPTLRNLENEQPVHLLR 289
V LL GA P + + P+ + +
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAK 775
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 68.6 bits (166), Expect = 7e-12
Identities = 75/281 (26%), Positives = 121/281 (43%), Gaps = 57/281 (20%)
Query: 68 AAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAAT 127
AA +LQ D+ G TPL +AA + + LLN GA N G + LH+A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 128 YGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNV--------------AMRPSDL 173
G ++ +L+ G Q++ + +D LTPLH A +V A + L
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Query: 174 CPRVLSTQARDRLDCVHMLLQMGA--------------------NHTSQEIKSNK----- 208
P ++ Q D LDCV +LLQ A +H ++ +K
Sbjct: 307 SPIHMAAQG-DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 209 -------TVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQE 261
T LH+A + + +++LLL+ + + G T LH+A+ + P
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTG----ASIDAVTESGLTPLHVASFMGHLP--- 418
Query: 262 AIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLK 302
IV++LL GA P + N++ E P+H+ E + LL+
Sbjct: 419 -IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/238 (28%), Positives = 101/238 (42%), Gaps = 34/238 (14%)
Query: 50 DTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGA 109
+T LH+ A G A +LQ +++ + +TPL AA +V+ LL A
Sbjct: 438 ETPLHMAARAG---HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 110 EPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMR 169
PN A G + LH+AA G +LA+L + +G TPLH A
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFTPLHVA--------- 543
Query: 170 PSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLEL 229
++ +LL+ A H + K+ T LH+AV N +V+LL L
Sbjct: 544 -----------AKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLL--L 589
Query: 230 PRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
PRG + + +G T LH+AA Q + R LL G +++ P+HL
Sbjct: 590 PRGG--SPHSPAWNGYTPLHIAAK----QNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Score = 59.3 bits (142), Expect = 4e-09
Identities = 70/250 (28%), Positives = 104/250 (41%), Gaps = 23/250 (9%)
Query: 46 DEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLL 105
++ G LHL + G E+L L+ KG T L +AA A Q +V +L+
Sbjct: 42 NQNGLNGLHLASKEG---HVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 106 NLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPL-------H 158
N GA NA +G + L++AA V+ +L +G ++ D G TPL H
Sbjct: 99 NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED--GFTPLAVALQQGH 156
Query: 159 TAILA--LNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQ 216
++A +N + P + D +LLQ N K+ T LH+A
Sbjct: 157 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS-KTGFTPLHIAAH 215
Query: 217 AANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTL 276
N + QLLL RG F +G T LH+A+ +VR LL GA
Sbjct: 216 YENLNVAQLLLN--RGASVNFT--PQNGITPLHIASR----RGNVIMVRLLLDRGAQIET 267
Query: 277 RNLENEQPVH 286
+ + P+H
Sbjct: 268 KTKDELTPLH 277
Score = 47.0 bits (110), Expect = 2e-05
Identities = 56/206 (27%), Positives = 82/206 (39%), Gaps = 33/206 (16%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +AA NQ + LL G NA QG + LH+AA G ++ +L+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI 204
+L + GLTPLH +V + +L++ G
Sbjct: 662 NLGNK--SGLTPLHLVAQEGHVPV--------------------ADVLIKHGV-MVDATT 698
Query: 205 KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAALPPGPAQEAI 263
+ T LH+A N LV+ LL+ + VN K G + LH AA I
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQ-----HQADVNAKTKLGYSPLHQAAQ----QGHTDI 749
Query: 264 VRHLLAAGADPTLRNLENEQPVHLLR 289
V LL GA P + + P+ + +
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAK 775
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 68.6 bits (166), Expect = 7e-12
Identities = 75/281 (26%), Positives = 121/281 (43%), Gaps = 57/281 (20%)
Query: 68 AAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAAT 127
AA +LQ D+ G TPL +AA + + LLN GA N G + LH+A+
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASR 248
Query: 128 YGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNV--------------AMRPSDL 173
G ++ +L+ G Q++ + +D LTPLH A +V A + L
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKD--ELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Query: 174 CPRVLSTQARDRLDCVHMLLQMGA--------------------NHTSQEIKSNK----- 208
P ++ Q D LDCV +LLQ A +H ++ +K
Sbjct: 307 SPIHMAAQG-DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 209 -------TVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQE 261
T LH+A + + +++LLL+ + + G T LH+A+ + P
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTG----ASIDAVTESGLTPLHVASFMGHLP--- 418
Query: 262 AIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLK 302
IV++LL GA P + N++ E P+H+ E + LL+
Sbjct: 419 -IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/238 (28%), Positives = 101/238 (42%), Gaps = 34/238 (14%)
Query: 50 DTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGA 109
+T LH+ A G A +LQ +++ + +TPL AA +V+ LL A
Sbjct: 438 ETPLHMAARAG---HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 110 EPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMR 169
PN A G + LH+AA G +LA+L + +G TPLH A
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEK--EASQACMTKKGFTPLHVA--------- 543
Query: 170 PSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLEL 229
++ +LL+ A H + K+ T LH+AV N +V+LL L
Sbjct: 544 -----------AKYGKVRVAELLLERDA-HPNAAGKNGLTPLHVAVHHNNLDIVKLL--L 589
Query: 230 PRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
PRG + + +G T LH+AA Q + R LL G +++ P+HL
Sbjct: 590 PRGG--SPHSPAWNGYTPLHIAAK----QNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Score = 59.3 bits (142), Expect = 4e-09
Identities = 70/250 (28%), Positives = 104/250 (41%), Gaps = 23/250 (9%)
Query: 46 DEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLL 105
++ G LHL + G E+L L+ KG T L +AA A Q +V +L+
Sbjct: 42 NQNGLNGLHLASKEG---HVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 106 NLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPL-------H 158
N GA NA +G + L++AA V+ +L +G ++ D G TPL H
Sbjct: 99 NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED--GFTPLAVALQQGH 156
Query: 159 TAILA--LNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQ 216
++A +N + P + D +LLQ N K+ T LH+A
Sbjct: 157 ENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS-KTGFTPLHIAAH 215
Query: 217 AANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTL 276
N + QLLL RG F +G T LH+A+ +VR LL GA
Sbjct: 216 YENLNVAQLLLN--RGASVNFT--PQNGITPLHIASR----RGNVIMVRLLLDRGAQIET 267
Query: 277 RNLENEQPVH 286
+ + P+H
Sbjct: 268 KTKDELTPLH 277
Score = 47.0 bits (110), Expect = 2e-05
Identities = 56/206 (27%), Positives = 82/206 (39%), Gaps = 33/206 (16%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +AA NQ + LL G NA QG + LH+AA G ++ +L+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI 204
+L + GLTPLH +V + +L++ G
Sbjct: 662 NLGNK--SGLTPLHLVAQEGHVPV--------------------ADVLIKHGV-MVDATT 698
Query: 205 KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMAAALPPGPAQEAI 263
+ T LH+A N LV+ LL+ + VN K G + LH AA I
Sbjct: 699 RMGYTPLHVASHYGNIKLVKFLLQ-----HQADVNAKTKLGYSPLHQAAQ----QGHTDI 749
Query: 264 VRHLLAAGADPTLRNLENEQPVHLLR 289
V LL GA P + + P+ + +
Sbjct: 750 VTLLLKNGASPNEVSSDGTTPLAIAK 775
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 67.4 bits (163), Expect = 2e-11
Identities = 68/239 (28%), Positives = 101/239 (42%), Gaps = 34/239 (14%)
Query: 49 GDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLG 108
G+T LH+ A G A ++Q +++ + +TPL ++A + IV+ LL G
Sbjct: 466 GETALHMAARSG---QAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522
Query: 109 AEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAM 168
A PNAA G + LH++A G V +L+ G + + + +G TPLH A
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK--KGFTPLHVA-------- 572
Query: 169 RPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLE 228
+L+ ++LLQ A+ + KS T LH+A N + LLL+
Sbjct: 573 ------------AKYGKLEVANLLLQKSASPDAAG-KSGLTPLHVAAHYDNQKVALLLLD 619
Query: 229 LPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
N G T LH+AA Q I LL GAD + VHL
Sbjct: 620 QGASPHAAAKN----GYTPLHIAAK----KNQMDIATTLLEYGADANAVTRQGIASVHL 670
Score = 65.1 bits (157), Expect = 8e-11
Identities = 79/305 (25%), Positives = 119/305 (39%), Gaps = 53/305 (17%)
Query: 42 LLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIV 101
LL D +G L + AAA +LQ D+ G TPL +AA +
Sbjct: 192 LLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251
Query: 102 EDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAI 161
LLN A + + LHVA+ G ++ +L+ G ++D + RD GLTPLH
Sbjct: 252 TLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD--GLTPLHCGA 309
Query: 162 --------------LALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSN 207
A ++ + L P ++TQ D L+CV +LLQ
Sbjct: 310 RSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG-DHLNCVQLLLQHNV-PVDDVTNDY 367
Query: 208 KTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKA-HGNTALHMAA----------ALPP 256
T LH+A + + ++LL D + N KA +G T LH+A L
Sbjct: 368 LTALHVAAHCGHYKVAKVLL-----DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422
Query: 257 GPAQEA-------------------IVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGL 297
G + +A IV L+ GA P N+ E +H+ E +
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482
Query: 298 RQLLK 302
R L++
Sbjct: 483 RYLVQ 487
Score = 62.0 bits (149), Expect = 7e-10
Identities = 74/224 (33%), Positives = 94/224 (41%), Gaps = 45/224 (20%)
Query: 40 QQLLAQDEE-------GDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVA 92
QQLL Q G T LHL A G AA +L L I KG TPL VA
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHE---DVAAFLLDHGASLSITTKKGFTPLHVA 572
Query: 93 AAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFE 152
A + + LL A P+AA G + LHVAA Y V L +L+ G A++
Sbjct: 573 AKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN-- 630
Query: 153 GLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANH---TSQEIKSNKT 209
G TPLH A ++++D LL+ GA+ T Q I S
Sbjct: 631 GYTPLHIA--------------------AKKNQMDIATTLLEYGADANAVTRQGIAS--- 667
Query: 210 VLHLAVQAANPTLVQLLLELPRGDLRTFVNM-KAHGNTALHMAA 252
+HLA Q + +V LLL VN+ G T LH+AA
Sbjct: 668 -VHLAAQEGHVDMVSLLL-----GRNANVNLSNKSGLTPLHLAA 705
Score = 60.8 bits (146), Expect = 1e-09
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 31/203 (15%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TP+ VAA IV L++ GA PN + +G + LH+AA G V+ ++ G QV
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI 204
+ +A+D + TPLH + + D V LLQ GA+ +
Sbjct: 493 EAKAKDDQ--TPLHI--------------------SARLGKADIVQQLLQQGAS-PNAAT 529
Query: 205 KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIV 264
S T LHL+ + + + LL+ G + K G T LH+AA + +
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLD--HGASLSITTKK--GFTPLHVAAKY----GKLEVA 581
Query: 265 RHLLAAGADPTLRNLENEQPVHL 287
LL A P P+H+
Sbjct: 582 NLLLQKSASPDAAGKSGLTPLHV 604
Score = 51.2 bits (121), Expect = 1e-06
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 31/201 (15%)
Query: 87 TPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDL 146
T L VAA + + LL+ A PNA G + LH+A V+ +L G +
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASI-- 426
Query: 147 EARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKS 206
+A GLTP+H A +V + V L+ GA+ + ++
Sbjct: 427 QAVTESGLTPIHVAAFMGHV--------------------NIVSQLMHHGASPNTTNVR- 465
Query: 207 NKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRH 266
+T LH+A ++ +V+ L++ D T LH++A L + IV+
Sbjct: 466 GETALHMAARSGQAEVVRYLVQ----DGAQVEAKAKDDQTPLHISARL----GKADIVQQ 517
Query: 267 LLAAGADPTLRNLENEQPVHL 287
LL GA P P+HL
Sbjct: 518 LLQQGASPNAATTSGYTPLHL 538
Score = 48.5 bits (114), Expect = 8e-06
Identities = 56/220 (25%), Positives = 90/220 (40%), Gaps = 31/220 (14%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +A N+ ++E LL GA A G + +HVAA G ++ +++ G
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI 204
+ + G T LH A S QA + V L+Q GA +
Sbjct: 460 N--TTNVRGETALHMA----------------ARSGQA----EVVRYLVQDGA-QVEAKA 496
Query: 205 KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIV 264
K ++T LH++ + +VQ LL+ + G T LH++A E +
Sbjct: 497 KDDQTPLHISARLGKADIVQQLLQQGASPNAATTS----GYTPLHLSAR----EGHEDVA 548
Query: 265 RHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRS 304
LL GA ++ + P+H+ E LL++S
Sbjct: 549 AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
Score = 47.0 bits (110), Expect = 2e-05
Identities = 55/203 (27%), Positives = 78/203 (38%), Gaps = 60/203 (29%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYG---LPGVLLA----- 136
G TPL +AA NQ I LL GA+ NA QG + +H+AA G + +LL
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690
Query: 137 -------------------------VLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPS 171
++N G VD + + G TPLH N+ +
Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK--MGYTPLHVGCHYGNIKI--- 745
Query: 172 DLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPR 231
V+ LLQ A + + K+ T LH A Q + ++ +LL+
Sbjct: 746 -----------------VNFLLQHSAK-VNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA 787
Query: 232 GDLRTFVNMKAHGNTALHMAAAL 254
VN GNTAL +A L
Sbjct: 788 SPNELTVN----GNTALGIARRL 806
Score = 43.1 bits (100), Expect = 3e-04
Identities = 26/83 (31%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 78 LDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV 137
+++ G TPL +AA ++ + E L+N GA +A G + LHV YG ++ +
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 138 LNSGVQVDLEARDFEGLTPLHTA 160
L +V+ + ++ G TPLH A
Sbjct: 750 LQHSAKVNAKTKN--GYTPLHQA 770
Score = 29.3 bits (64), Expect = 4.7
Identities = 19/64 (29%), Positives = 28/64 (43%)
Query: 71 VLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGL 130
+LQ +++ + G TPL AA I+ LL A PN G + L +A G
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGY 808
Query: 131 PGVL 134
V+
Sbjct: 809 ISVV 812
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 67.4 bits (163), Expect = 2e-11
Identities = 62/184 (33%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G+TPL +AA+ V+ LL GA NA D +GR+ +HVA + GV++ +L S +
Sbjct: 771 GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAIS-SQHGVIIQLLVSHPDI 829
Query: 145 DLEARDFEGLTPLHTAILALN------VAMRPSDLCPRV---------LSTQARDRLDCV 189
L RD +GLTP A+ N + R S +V ++ Q D ++ V
Sbjct: 830 HLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSD-IESV 888
Query: 190 HMLLQMGANHTSQEIKSNK-TVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTAL 248
L+ + AN S+ ++K T LHLAVQA + +V+ LL L + + H TAL
Sbjct: 889 LFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLL-LAGAKVN---ELTKHRQTAL 944
Query: 249 HMAA 252
H+AA
Sbjct: 945 HLAA 948
Score = 52.4 bits (124), Expect = 5e-07
Identities = 56/186 (30%), Positives = 81/186 (43%), Gaps = 16/186 (8%)
Query: 100 IVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHT 159
I E LL GA PN D +GR+ LHV+ G V +L Q+DLE +D EG T L
Sbjct: 349 IAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQC-KQLDLELKDHEGSTALWL 407
Query: 160 AILALNV----AMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAV 215
A+ + V ++ P + P V++ + D L+Q G++ + + + +L A
Sbjct: 408 AVQHITVSSDQSVNPFEDVP-VVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAA 466
Query: 216 QAANPTLVQLLLELPRGDLRTFVNMK-AHGNTALHMAAALPPGPAQEAIVRHLLAAGADP 274
A N L VN + G T LH A G A + LL GA+P
Sbjct: 467 GAGNEAAALFL-----ATNGAHVNHRNKWGETPLHTACR--HGLAN--LTAELLQQGANP 517
Query: 275 TLRNLE 280
L+ E
Sbjct: 518 NLQTEE 523
Score = 45.8 bits (107), Expect = 5e-05
Identities = 28/76 (36%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 87 TPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDL 146
TPL +A A +IV +LL GA+ N ++ LH+AA LP + +L +G VD
Sbjct: 909 TPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENG--VDF 966
Query: 147 EARDFEGLTPLHTAIL 162
A D G LH A++
Sbjct: 967 AAVDENGNNALHLAVM 982
Score = 44.7 bits (104), Expect = 1e-04
Identities = 51/180 (28%), Positives = 84/180 (46%), Gaps = 16/180 (8%)
Query: 73 QVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPG 132
Q+ +L+ +H G L +A + I L++ A+ + D G S+LH G
Sbjct: 244 QLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLF 303
Query: 133 VLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHML 192
++ +G V+ + TPLH ++AL + + S V+S A+ L
Sbjct: 304 AATFLIKNGAFVNAATLGAQE-TPLH--LVALYSSKKHS---ADVMSEMAQ----IAEAL 353
Query: 193 LQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAH-GNTALHMA 251
LQ GAN Q+ K +T LH+++ A N + LL+ + DL +K H G+TAL +A
Sbjct: 354 LQAGANPNMQDSK-GRTPLHVSIMAGNEYVFSQLLQCKQLDL----ELKDHEGSTALWLA 408
Score = 43.9 bits (102), Expect = 2e-04
Identities = 60/225 (26%), Positives = 92/225 (40%), Gaps = 25/225 (11%)
Query: 48 EGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDI-REHKGKTPLLVAAAANQPLIVEDLLN 106
+G TLLH+ R + +A +L+ +++ R G+T L +A PL+V+ +
Sbjct: 621 DGQTLLHMAIQRQ---DSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICT 677
Query: 107 LGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGL--TPLHTAILAL 164
GA+ + D +G L +A L + ++ G G T LH AI
Sbjct: 678 RGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDEN 737
Query: 165 NVAMRPSDLCPRVLSTQARDRLDC-VHMLLQMGAN-HTSQEIKSNKTVLHLAVQAANPTL 222
N C + R C V+ Q GAN +E + +T LHLA
Sbjct: 738 N----EPTACFLI-------RSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEET 786
Query: 223 VQLLLELPRGDLRTFVNMK-AHGNTALHMAAALPPGPAQEAIVRH 266
VQ LLE VN + A G T +H+A + G + +V H
Sbjct: 787 VQCLLEFGAN-----VNAQDAEGRTPIHVAISSQHGVIIQLLVSH 826
Score = 35.4 bits (80), Expect = 0.066
Identities = 45/179 (25%), Positives = 67/179 (37%), Gaps = 19/179 (10%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G L AA A L GA N + G + LH A +GL + +L G
Sbjct: 458 GNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANP 517
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGAN--HTSQ 202
+L+ E PL +L L + A + D V ++L+ AN H +
Sbjct: 518 NLQT---EEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATN 574
Query: 203 EIK----------SNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMA 251
++ ++TVL LA+ T+ LL G + + G T LHMA
Sbjct: 575 NLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLL----GSGAAINDTMSDGQTLLHMA 629
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 65.5 bits (158), Expect = 6e-11
Identities = 62/213 (29%), Positives = 97/213 (45%), Gaps = 33/213 (15%)
Query: 82 EHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSG 141
+ +T L A +A IVE LL LG N D G S LH+AA+ G ++ A+L G
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
Query: 142 VQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTS 201
QV+ A + G TPLH A +++R + MLL+ GAN +
Sbjct: 97 AQVN--AVNQNGCTPLHYA--------------------ASKNRHEIAVMLLEGGANPDA 134
Query: 202 QEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMK-AHGNTALHMAAALPPGPAQ 260
++ T +H A N ++ +LL + N++ GNT LH+A +
Sbjct: 135 KD-HYEATAMHRAAAKGNLKMIHILLY-----YKASTNIQDTEGNTPLHLAC--DEERVE 186
Query: 261 EAIVRHLLAAGADPTLRNLENEQPVHLLRPGPG 293
EA + L++ GA + N E + P+ + + G G
Sbjct: 187 EA--KLLVSQGASIYIENKEEKTPLQVAKGGLG 217
Score = 53.9 bits (128), Expect = 2e-07
Identities = 51/187 (27%), Positives = 82/187 (43%), Gaps = 36/187 (19%)
Query: 46 DEEGDTLLHLFAARGLRWAAYAA-AEVLQVYRRLDI----REHKGKTPLLVAAAANQPLI 100
D++ T LH WA A E+++ +L + ++ G +PL +AA+A + I
Sbjct: 37 DQDSRTALH--------WACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEI 88
Query: 101 VEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTA 160
V+ LL GA+ NA + G + LH AA+ + + +L G D A+D T +H A
Sbjct: 89 VKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD--AKDHYEATAMHRA 146
Query: 161 ILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANP 220
A+ L +H+LL A+ Q+ + N T LHLA
Sbjct: 147 --------------------AAKGNLKMIHILLYYKASTNIQDTEGN-TPLHLACDEERV 185
Query: 221 TLVQLLL 227
+LL+
Sbjct: 186 EEAKLLV 192
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 65.5 bits (158), Expect = 6e-11
Identities = 71/255 (27%), Positives = 116/255 (45%), Gaps = 33/255 (12%)
Query: 45 QDEEGDTLLHLFAARG-LRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVED 103
+ ++G TLLH A +G + A+ ++ V LD + G+T AA Q ++
Sbjct: 120 ESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV--ALDHVDKLGRTAFHRAAEHGQLDALDF 177
Query: 104 LLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAI-- 161
L+ G + N D +G + LH+AA G VL +++ G +DLE ++ EGLT LH+A
Sbjct: 178 LVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG--LDLEEQNAEGLTALHSAAGG 235
Query: 162 ---LALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI-----------KSN 207
+ + +R ++ + L C+H G+ S+ +
Sbjct: 236 SHPDCVQLLLRAGS----TVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQG 291
Query: 208 KTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHL 267
+ LHLAV+ P LV+LL+ D+ N + T LH+AA A + I L
Sbjct: 292 ASPLHLAVRHNFPALVRLLIN-SDSDVNAVDNRQ---QTPLHLAAE----HAWQDIADML 343
Query: 268 LAAGADPTLRNLENE 282
L AG D LR+ + +
Sbjct: 344 LIAGVDLNLRDKQGK 358
Score = 53.1 bits (126), Expect = 3e-07
Identities = 60/222 (27%), Positives = 90/222 (40%), Gaps = 63/222 (28%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREH--KGKTPLLVAAAANQPLIVE 102
+D+EG+T LHL A RG ++ LD+ E +G T L AA + P V+
Sbjct: 188 KDKEGNTALHLAAGRGHMAVLQRLVDI-----GLDLEEQNAEGLTALHSAAGGSHPDCVQ 242
Query: 103 DLLNLGAEPNA---------------------------------ADHQGRSVLHVAATYG 129
LL G+ NA DHQG S LH+A +
Sbjct: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302
Query: 130 LPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCV 189
P ++ ++NS D+ A D TPLH LA A + D
Sbjct: 303 FPALVRLLINS--DSDVNAVDNRQQTPLH---LAAEHAWQ-----------------DIA 340
Query: 190 HMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPR 231
MLL G + ++ K KT L +AV++ + +LV ++++ R
Sbjct: 341 DMLLIAGVDLNLRD-KQGKTALAVAVRSNHVSLVDMIIKADR 381
Score = 51.2 bits (121), Expect = 1e-06
Identities = 55/202 (27%), Positives = 84/202 (41%), Gaps = 29/202 (14%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G LL++A I++ L+N GA+ + G ++LH AA G VL ++ V
Sbjct: 91 GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEI 204
L+ D G T H A +LD + L+ G +H ++
Sbjct: 151 ALDHVDKLGRTAFHRA--------------------AEHGQLDALDFLVGSGCDHNVKD- 189
Query: 205 KSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIV 264
K T LHLA + ++Q L+++ DL A G TALH AA G + V
Sbjct: 190 KEGNTALHLAAGRGHMAVLQRLVDIGL-DLE---EQNAEGLTALHSAA----GGSHPDCV 241
Query: 265 RHLLAAGADPTLRNLENEQPVH 286
+ LL AG+ +N +H
Sbjct: 242 QLLLRAGSTVNALTQKNLSCLH 263
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 64.3 bits (155), Expect = 1e-10
Identities = 72/243 (29%), Positives = 100/243 (41%), Gaps = 42/243 (17%)
Query: 49 GDTLLHLFAARGLRWAAYAAAEVLQVYRR----LDIREHKGKTPLLVAAAANQPLIVEDL 104
G+T LH+ A G EV++ R +D R + +TPL +A+ + IV+ L
Sbjct: 443 GETALHMAARAG-------QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Query: 105 LNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILAL 164
L A P+AA G + LH++A G V +L +G L + +G TPLH A
Sbjct: 496 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVA---- 549
Query: 165 NVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQ 224
LD +LLQ A S K+ T LH+A N +
Sbjct: 550 ----------------AKYGSLDVAKLLLQRRAAADSAG-KNGLTPLHVAAHYDNQKVAL 592
Query: 225 LLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQP 284
LLLE T N G T LH+AA Q I LL GA+ + + P
Sbjct: 593 LLLEKGASPHATAKN----GYTPLHIAAK----KNQMQIASTLLNYGAETNIVTKQGVTP 644
Query: 285 VHL 287
+HL
Sbjct: 645 LHL 647
Score = 63.2 bits (152), Expect = 3e-10
Identities = 82/313 (26%), Positives = 121/313 (38%), Gaps = 61/313 (19%)
Query: 42 LLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIRE--------HKGKTPLLVAA 93
LL D +G L + +AA +LQ D++ G TPL +AA
Sbjct: 161 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 220
Query: 94 AANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEG 153
+ LLN GA + G + LHVA+ G ++ +L+ G Q+D + RD G
Sbjct: 221 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD--G 278
Query: 154 LTPLHTAIL--------------ALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANH 199
LTPLH A A +A + L P ++ Q D ++CV LLQ A
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG-DHVECVKHLLQHKA-P 336
Query: 200 TSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKA-HGNTALHMAAALPPGP 258
T LH+A + + +LLL D R N +A +G T LH+A
Sbjct: 337 VDDVTLDYLTALHVAAHCGHYRVTKLLL-----DKRANPNARALNGFTPLHIACKKNRIK 391
Query: 259 AQEAIVRH-----------------------------LLAAGADPTLRNLENEQPVHLLR 289
E +V++ LL GA P + N+ E +H+
Sbjct: 392 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 451
Query: 290 PGPGPEGLRQLLK 302
E +R LL+
Sbjct: 452 RAGQVEVVRCLLR 464
Score = 63.2 bits (152), Expect = 3e-10
Identities = 58/185 (31%), Positives = 87/185 (47%), Gaps = 24/185 (12%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +AA NQ I LLN GAE N QG + LH+A+ G ++ +L+ G +
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQ-ARDRL--------------DCV 189
+ + GLT LH A A + +D+ + + Q A +L V
Sbjct: 668 HMSTK--SGLTSLHLA--AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 723
Query: 190 HMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALH 249
+ LL+ GAN + + K+ T LH A Q + ++ +LL+ T A+GNTAL
Sbjct: 724 NFLLKQGAN-VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT----TANGNTALA 778
Query: 250 MAAAL 254
+A L
Sbjct: 779 IAKRL 783
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/216 (31%), Positives = 92/216 (42%), Gaps = 24/216 (11%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TP+ VAA IV LL GA P+ + +G + LH+AA G V+ +L +G V
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469
Query: 145 DLEARDFEGLTPLHTAI---------LALNVAMRPSDLCPR---VLSTQARD-RLDCVHM 191
D AR E TPLH A L L P L AR+ ++D +
Sbjct: 470 DARAR--EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527
Query: 192 LLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMA 251
LL+ GA H S K T LH+A + + + +LLL+ N G T LH+A
Sbjct: 528 LLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN----GLTPLHVA 582
Query: 252 AALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
A + + LL GA P P+H+
Sbjct: 583 AHYD----NQKVALLLLEKGASPHATAKNGYTPLHI 614
Score = 59.7 bits (143), Expect = 3e-09
Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 33/228 (14%)
Query: 81 REHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNS 140
R G TPL +A N+ ++E L+ GA A G + +HVAA G ++L +L +
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 432
Query: 141 GVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHT 200
G D+ + G T LH A A +++ V LL+ GA
Sbjct: 433 GASPDV--TNIRGETALHMAARA--------------------GQVEVVRCLLRNGA-LV 469
Query: 201 SQEIKSNKTVLHLAVQAANPTLVQLLLE-LPRGDLRTFVNMKAHGNTALHMAAALPPGPA 259
+ +T LH+A + +VQLLL+ + D T +G T LH++A
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT-----TNGYTPLHISAR----EG 520
Query: 260 QEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRVA 307
Q + LL AGA +L + P+H+ + + LL+R A
Sbjct: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Score = 32.3 bits (72), Expect = 0.56
Identities = 19/57 (33%), Positives = 27/57 (47%)
Query: 78 LDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVL 134
++ + G TPL AA I+ LL GA+PNA G + L +A G V+
Sbjct: 733 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 64.3 bits (155), Expect = 1e-10
Identities = 72/243 (29%), Positives = 100/243 (41%), Gaps = 42/243 (17%)
Query: 49 GDTLLHLFAARGLRWAAYAAAEVLQVYRR----LDIREHKGKTPLLVAAAANQPLIVEDL 104
G+T LH+ A G EV++ R +D R + +TPL +A+ + IV+ L
Sbjct: 464 GETALHMAARAG-------QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 105 LNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILAL 164
L A P+AA G + LH++A G V +L +G L + +G TPLH A
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVA---- 570
Query: 165 NVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQ 224
LD +LLQ A S K+ T LH+A N +
Sbjct: 571 ----------------AKYGSLDVAKLLLQRRAAADSAG-KNGLTPLHVAAHYDNQKVAL 613
Query: 225 LLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQP 284
LLLE T N G T LH+AA Q I LL GA+ + + P
Sbjct: 614 LLLEKGASPHATAKN----GYTPLHIAAK----KNQMQIASTLLNYGAETNIVTKQGVTP 665
Query: 285 VHL 287
+HL
Sbjct: 666 LHL 668
Score = 63.2 bits (152), Expect = 3e-10
Identities = 82/313 (26%), Positives = 121/313 (38%), Gaps = 61/313 (19%)
Query: 42 LLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIRE--------HKGKTPLLVAA 93
LL D +G L + +AA +LQ D++ G TPL +AA
Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241
Query: 94 AANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEG 153
+ LLN GA + G + LHVA+ G ++ +L+ G Q+D + RD G
Sbjct: 242 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD--G 299
Query: 154 LTPLHTAIL--------------ALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANH 199
LTPLH A A +A + L P ++ Q D ++CV LLQ A
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG-DHVECVKHLLQHKA-P 357
Query: 200 TSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKA-HGNTALHMAAALPPGP 258
T LH+A + + +LLL D R N +A +G T LH+A
Sbjct: 358 VDDVTLDYLTALHVAAHCGHYRVTKLLL-----DKRANPNARALNGFTPLHIACKKNRIK 412
Query: 259 AQEAIVRH-----------------------------LLAAGADPTLRNLENEQPVHLLR 289
E +V++ LL GA P + N+ E +H+
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 472
Query: 290 PGPGPEGLRQLLK 302
E +R LL+
Sbjct: 473 RAGQVEVVRCLLR 485
Score = 63.2 bits (152), Expect = 3e-10
Identities = 58/185 (31%), Positives = 87/185 (47%), Gaps = 24/185 (12%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +AA NQ I LLN GAE N QG + LH+A+ G ++ +L+ G +
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQ-ARDRL--------------DCV 189
+ + GLT LH A A + +D+ + + Q A +L V
Sbjct: 689 HMSTK--SGLTSLHLA--AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744
Query: 190 HMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALH 249
+ LL+ GAN + + K+ T LH A Q + ++ +LL+ T A+GNTAL
Sbjct: 745 NFLLKQGAN-VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT----TANGNTALA 799
Query: 250 MAAAL 254
+A L
Sbjct: 800 IAKRL 804
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/216 (31%), Positives = 92/216 (42%), Gaps = 24/216 (11%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TP+ VAA IV LL GA P+ + +G + LH+AA G V+ +L +G V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 145 DLEARDFEGLTPLHTAI---------LALNVAMRPSDLCPR---VLSTQARD-RLDCVHM 191
D AR E TPLH A L L P L AR+ ++D +
Sbjct: 491 DARAR--EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 192 LLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMA 251
LL+ GA H S K T LH+A + + + +LLL+ N G T LH+A
Sbjct: 549 LLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN----GLTPLHVA 603
Query: 252 AALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
A + + LL GA P P+H+
Sbjct: 604 AHYD----NQKVALLLLEKGASPHATAKNGYTPLHI 635
Score = 59.7 bits (143), Expect = 3e-09
Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 33/228 (14%)
Query: 81 REHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNS 140
R G TPL +A N+ ++E L+ GA A G + +HVAA G ++L +L +
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 141 GVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHT 200
G D+ + G T LH A A +++ V LL+ GA
Sbjct: 454 GASPDV--TNIRGETALHMAARA--------------------GQVEVVRCLLRNGA-LV 490
Query: 201 SQEIKSNKTVLHLAVQAANPTLVQLLLE-LPRGDLRTFVNMKAHGNTALHMAAALPPGPA 259
+ +T LH+A + +VQLLL+ + D T +G T LH++A
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT-----TNGYTPLHISAR----EG 541
Query: 260 QEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRVA 307
Q + LL AGA +L + P+H+ + + LL+R A
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Score = 32.3 bits (72), Expect = 0.56
Identities = 19/57 (33%), Positives = 27/57 (47%)
Query: 78 LDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVL 134
++ + G TPL AA I+ LL GA+PNA G + L +A G V+
Sbjct: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 64.3 bits (155), Expect = 1e-10
Identities = 72/243 (29%), Positives = 100/243 (41%), Gaps = 42/243 (17%)
Query: 49 GDTLLHLFAARGLRWAAYAAAEVLQVYRR----LDIREHKGKTPLLVAAAANQPLIVEDL 104
G+T LH+ A G EV++ R +D R + +TPL +A+ + IV+ L
Sbjct: 464 GETALHMAARAG-------QVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 105 LNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILAL 164
L A P+AA G + LH++A G V +L +G L + +G TPLH A
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPLHVA---- 570
Query: 165 NVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQ 224
LD +LLQ A S K+ T LH+A N +
Sbjct: 571 ----------------AKYGSLDVAKLLLQRRAAADSAG-KNGLTPLHVAAHYDNQKVAL 613
Query: 225 LLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQP 284
LLLE T N G T LH+AA Q I LL GA+ + + P
Sbjct: 614 LLLEKGASPHATAKN----GYTPLHIAAK----KNQMQIASTLLNYGAETNIVTKQGVTP 665
Query: 285 VHL 287
+HL
Sbjct: 666 LHL 668
Score = 63.2 bits (152), Expect = 3e-10
Identities = 82/313 (26%), Positives = 121/313 (38%), Gaps = 61/313 (19%)
Query: 42 LLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIRE--------HKGKTPLLVAA 93
LL D +G L + +AA +LQ D++ G TPL +AA
Sbjct: 182 LLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAA 241
Query: 94 AANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEG 153
+ LLN GA + G + LHVA+ G ++ +L+ G Q+D + RD G
Sbjct: 242 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD--G 299
Query: 154 LTPLHTAIL--------------ALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANH 199
LTPLH A A +A + L P ++ Q D ++CV LLQ A
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG-DHVECVKHLLQHKA-P 357
Query: 200 TSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKA-HGNTALHMAAALPPGP 258
T LH+A + + +LLL D R N +A +G T LH+A
Sbjct: 358 VDDVTLDYLTALHVAAHCGHYRVTKLLL-----DKRANPNARALNGFTPLHIACKKNRIK 412
Query: 259 AQEAIVRH-----------------------------LLAAGADPTLRNLENEQPVHLLR 289
E +V++ LL GA P + N+ E +H+
Sbjct: 413 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAA 472
Query: 290 PGPGPEGLRQLLK 302
E +R LL+
Sbjct: 473 RAGQVEVVRCLLR 485
Score = 63.2 bits (152), Expect = 3e-10
Identities = 58/185 (31%), Positives = 87/185 (47%), Gaps = 24/185 (12%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TPL +AA NQ I LLN GAE N QG + LH+A+ G ++ +L+ G +
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 145 DLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQ-ARDRL--------------DCV 189
+ + GLT LH A A + +D+ + + Q A +L V
Sbjct: 689 HMSTK--SGLTSLHLA--AQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744
Query: 190 HMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALH 249
+ LL+ GAN + + K+ T LH A Q + ++ +LL+ T A+GNTAL
Sbjct: 745 NFLLKQGAN-VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT----TANGNTALA 799
Query: 250 MAAAL 254
+A L
Sbjct: 800 IAKRL 804
Score = 60.5 bits (145), Expect = 2e-09
Identities = 67/216 (31%), Positives = 92/216 (42%), Gaps = 24/216 (11%)
Query: 85 GKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQV 144
G TP+ VAA IV LL GA P+ + +G + LH+AA G V+ +L +G V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 145 DLEARDFEGLTPLHTAI---------LALNVAMRPSDLCPR---VLSTQARD-RLDCVHM 191
D AR E TPLH A L L P L AR+ ++D +
Sbjct: 491 DARAR--EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 192 LLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMA 251
LL+ GA H S K T LH+A + + + +LLL+ N G T LH+A
Sbjct: 549 LLEAGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN----GLTPLHVA 603
Query: 252 AALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
A + + LL GA P P+H+
Sbjct: 604 AHYD----NQKVALLLLEKGASPHATAKNGYTPLHI 635
Score = 59.7 bits (143), Expect = 3e-09
Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 33/228 (14%)
Query: 81 REHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNS 140
R G TPL +A N+ ++E L+ GA A G + +HVAA G ++L +L +
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN 453
Query: 141 GVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHT 200
G D+ + G T LH A A +++ V LL+ GA
Sbjct: 454 GASPDV--TNIRGETALHMAARA--------------------GQVEVVRCLLRNGA-LV 490
Query: 201 SQEIKSNKTVLHLAVQAANPTLVQLLLE-LPRGDLRTFVNMKAHGNTALHMAAALPPGPA 259
+ +T LH+A + +VQLLL+ + D T +G T LH++A
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT-----TNGYTPLHISAR----EG 541
Query: 260 QEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRVA 307
Q + LL AGA +L + P+H+ + + LL+R A
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Score = 32.3 bits (72), Expect = 0.56
Identities = 19/57 (33%), Positives = 27/57 (47%)
Query: 78 LDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVL 134
++ + G TPL AA I+ LL GA+PNA G + L +A G V+
Sbjct: 754 VNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 63.9 bits (154), Expect = 2e-10
Identities = 61/211 (28%), Positives = 91/211 (43%), Gaps = 33/211 (15%)
Query: 78 LDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAV 137
LD+++ G+ L VAA + + L + G+ PN D + + LH AA +G V A+
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497
Query: 138 LNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGA 197
+G V+++ R EG TPL TA AR D V L + GA
Sbjct: 498 CEAGCNVNIKNR--EGETPLLTA--------------------SARGYHDIVECLAEHGA 535
Query: 198 NHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMK-AHGNTALHMAAALPP 256
+ + + K LHLAV+ +++ LL FV+ + HGNT LH+A
Sbjct: 536 DLNACD-KDGHIALHLAVRRCQMEVIKTLL-----SQGCFVDYQDRHGNTPLHVACK--- 586
Query: 257 GPAQEAIVRHLLAAGADPTLRNLENEQPVHL 287
IV L A + + N P+HL
Sbjct: 587 -DGNMPIVVALCEANCNLDISNKYGRTPLHL 616
Score = 60.1 bits (144), Expect = 2e-09
Identities = 44/117 (37%), Positives = 61/117 (52%), Gaps = 7/117 (5%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVL-QVYRRLDIREHKGKTPLLVAAAANQPLIVED 103
QD+E +T LH A G Y+ A+ L + ++I+ +G+TPLL A+A IVE
Sbjct: 474 QDKEEETPLHCAAWHGY----YSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVEC 529
Query: 104 LLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTA 160
L GA+ NA D G LH+A V+ +L+ G VD + D G TPLH A
Sbjct: 530 LAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ--DRHGNTPLHVA 584
Score = 34.7 bits (78), Expect = 0.11
Identities = 31/113 (27%), Positives = 47/113 (41%), Gaps = 11/113 (9%)
Query: 42 LLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRR----LDIREHKGKTPLLVAAAANQ 97
L A D++G LHL R EV++ +D ++ G TPL VA
Sbjct: 537 LNACDKDGHIALHLAVRR-------CQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGN 589
Query: 98 PLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARD 150
IV L + ++ GR+ LH+AA G+ V+ + G V+ D
Sbjct: 590 MPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTD 642
Score = 28.9 bits (63), Expect = 6.2
Identities = 25/81 (30%), Positives = 34/81 (41%), Gaps = 3/81 (3%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDL 104
QD G+T LH+ G A E LDI G+TPL +AA +V L
Sbjct: 573 QDRHGNTPLHVACKDGNMPIVVALCEA---NCNLDISNKYGRTPLHLAANNGILDVVRYL 629
Query: 105 LNLGAEPNAADHQGRSVLHVA 125
+GA A G++ +A
Sbjct: 630 CLMGASVEALTTDGKTAEDLA 650
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 63.9 bits (154), Expect = 2e-10
Identities = 79/262 (30%), Positives = 114/262 (43%), Gaps = 54/262 (20%)
Query: 89 LLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEA 148
LLVAA Q V L+N GA H GR+ LH+AA G V+ +L +G DL+
Sbjct: 14 LLVAAYKGQTENVVQLINKGARVAVTKH-GRTPLHLAANKGHLPVVQILLKAGC--DLDV 70
Query: 149 RDFEGLTPLHTAILALN---VAMRPSDLCPRVLSTQARDRLDCVH------------MLL 193
+D T LH A + N +A + C L Q +D +H +L+
Sbjct: 71 QDDGDQTALHRATVVGNTEIIAALIHEGC--ALDRQDKDGNTALHEASWHGFSQSAKLLV 128
Query: 194 QMGANHTSQEIKSNKTVLHLAVQAANPTLVQ-LLLELPRGDLR-----TFVNMKAH---- 243
+ GAN ++ K+ T LHLA Q ++ + LLL R DL+ T +++ A
Sbjct: 129 KAGANVLAKN-KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHL 187
Query: 244 -------------------GNTALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQP 284
G+TALH+AAAL + + + LL AGAD T+ N + P
Sbjct: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALN----HKKVAKILLEAGADTTIVNNAGQTP 243
Query: 285 VHLLRPGPGPEGLRQLLKRSRV 306
+ R PE L K +V
Sbjct: 244 LETARYHNNPEVALLLTKAPQV 265
Score = 44.3 bits (103), Expect = 1e-04
Identities = 38/129 (29%), Positives = 57/129 (44%), Gaps = 5/129 (3%)
Query: 32 AHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLV 91
A +L +LA+++ G+T LHL + + +L R D++ + G T L V
Sbjct: 124 AKLLVKAGANVLAKNKAGNTALHLACQNS---HSQSTRVLLLAGSRADLKNNAGDTCLHV 180
Query: 92 AAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDF 151
AA N I+ LL + + G + LHVAA V +L +G D +
Sbjct: 181 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG--ADTTIVNN 238
Query: 152 EGLTPLHTA 160
G TPL TA
Sbjct: 239 AGQTPLETA 247
Score = 34.7 bits (78), Expect = 0.11
Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 3/102 (2%)
Query: 34 MLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAA 93
+L L + ++ GDT LH+ AAR + +L + + + G T L VAA
Sbjct: 159 VLLLAGSRADLKNNAGDTCLHV-AARYNHLSIIRL--LLTAFCSVHEKNQAGDTALHVAA 215
Query: 94 AANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLL 135
A N + + LL GA+ ++ G++ L A + P V L
Sbjct: 216 ALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVAL 257
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 63.5 bits (153), Expect = 2e-10
Identities = 80/276 (28%), Positives = 113/276 (40%), Gaps = 46/276 (16%)
Query: 35 LALGPQQLLAQDEEGDTLL----HLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLL 90
+ L ++ L EG +++ HL A R A ++L+ ++ R+H G+TPL
Sbjct: 21 MELDSEEALGTRTEGPSVVQGWGHLLQAVW-RGPAGLVTQLLRQGASVEERDHAGRTPLH 79
Query: 91 VAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARD 150
+A +V LL GA A D GR+ LH AA +G V +L G AR
Sbjct: 80 LAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASA--AARS 137
Query: 151 FEGLTPLHTA------ILALNVAMRPSDLCPRVLSTQARD--------------RLDCVH 190
GLTPLH A +LA + P P + +A D RL +
Sbjct: 138 GTGLTPLHWAAALGHTLLAARLLEAPG---PGPAAAEAEDARGWTAAHWAAAGGRLAVLE 194
Query: 191 MLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHM 250
+L GA + +L A L LL R D R G TAL +
Sbjct: 195 LLAAGGAG-------LDGALLVAAAAGRGAALRFLLARGARVDAR-----DGAGATALGL 242
Query: 251 AAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVH 286
AAAL G +Q+ + LL GADP +R+ +H
Sbjct: 243 AAAL--GRSQD--IEVLLGHGADPGIRDRHGRSALH 274
Score = 60.8 bits (146), Expect = 1e-09
Identities = 56/149 (37%), Positives = 70/149 (46%), Gaps = 15/149 (10%)
Query: 23 PGPSLEVAR-------AHMLALGPQ----QLLAQDEEGDTLLHLFAARGLRWAAYAAAEV 71
PGP+ A AH A G + +LLA G L AA R AA +
Sbjct: 165 PGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRF--L 222
Query: 72 LQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLP 131
L R+D R+ G T L +AAA + +E LL GA+P D GRS LH AA G
Sbjct: 223 LARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHL 282
Query: 132 GVLLAVLNSGVQVDLEARDFEGLTPLHTA 160
+ ++ G +VD ARD GLTPLH A
Sbjct: 283 LAVQLLVTQGAEVD--ARDTLGLTPLHHA 309
Score = 43.1 bits (100), Expect = 3e-04
Identities = 44/118 (37%), Positives = 57/118 (48%), Gaps = 7/118 (5%)
Query: 44 AQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRR-LDIREHKGKTPLLVAAAANQPLIVE 102
A+D G T L L AA G EVL + IR+ G++ L AAA L V+
Sbjct: 231 ARDGAGATALGLAAALGRS----QDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQ 286
Query: 103 DLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTA 160
L+ GAE +A D G + LH A+ G V +L+ G QVD A + TPLH A
Sbjct: 287 LLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVD--ATGWLRKTPLHLA 342
Score = 33.9 bits (76), Expect = 0.19
Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 3/105 (2%)
Query: 45 QDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDL 104
+D G + LH AARG A ++ +D R+ G TPL A+ + L
Sbjct: 265 RDRHGRSALHRAAARG---HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCL 321
Query: 105 LNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEAR 149
L+ GA+ +A ++ LH+AA G + +L+ G L +
Sbjct: 322 LDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 62.4 bits (150), Expect = 5e-10
Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 22/213 (10%)
Query: 33 HMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRLDIREHKGKTPLLVA 92
H+LA+G D+EG + + E+L+ +++ + G T L++A
Sbjct: 188 HLLAMGADV----DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIA 243
Query: 93 AAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFE 152
+ IV+DLL+ G N D G +VL A G ++ A+L +D+ +D
Sbjct: 244 SKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD-- 301
Query: 153 GLTPLHTAILALNVAM--------RPSDLC------PRVLSTQARDRLDCVHMLLQMGAN 198
T L+ A+ N M +++C P + +T+ R+ ++ V +LL GA
Sbjct: 302 NKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRN-IEVVELLLDKGAK 360
Query: 199 HTSQEIKSNKTVLHLAVQAANPTLVQLLLELPR 231
++ + K T LH+A++ + L +LLL P+
Sbjct: 361 VSAVD-KKGDTPLHIAIRGRSRKLAELLLRNPK 392
Score = 52.0 bits (123), Expect = 7e-07
Identities = 63/238 (26%), Positives = 101/238 (42%), Gaps = 31/238 (13%)
Query: 67 AAAEVLQVYRRLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAA 126
A +L+ + +D R G+TPL++AA IV++L+ GA N D + L A+
Sbjct: 20 ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS 79
Query: 127 TYGLPGVLLAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRL 186
G ++ +L G V+LE RD G T L A + R
Sbjct: 80 KEGHVHIVEELLKCG--VNLEHRDMGGWTALMWACY--------------------KGRT 117
Query: 187 DCVHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNT 246
D V +LL GAN + + S ++ A + +V LLL+ + + K +G T
Sbjct: 118 DVVELLLSHGANPSVTGLYSVYPII-WAAGRGHADIVHLLLQ---NGAKVNCSDK-YGTT 172
Query: 247 ALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRS 304
L AA V+HLLA GAD + + + G + ++++LKR+
Sbjct: 173 PLVWAAR----KGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRN 226
Score = 41.6 bits (96), Expect = 0.001
Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 36/285 (12%)
Query: 41 QLLAQDEEGDTLLHLFAARGLRWAAYAAAE-----VLQVYRRLDIREHKGKTPLLVAAAA 95
+LL ++ L++ + WAA +LQ +++ + G TPL+ AA
Sbjct: 121 ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180
Query: 96 NQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVLNSGVQVDLEARDFEGLT 155
V+ LL +GA+ + + L VA G + +L V+L +D G T
Sbjct: 181 GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKD--GNT 238
Query: 156 PL-------HTAILA--------LNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHT 200
L HT I+ +N+ R D ++ ++ V LLQ A+
Sbjct: 239 ALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTV--LIGAVRGGHVEIVRALLQKYADID 296
Query: 201 SQEIKSNKTVLHLAVQAANPTLVQLLLEL-PRGDLRTFVNMKAHGNTALHMAAALPPGPA 259
+ + NKT L+ AV+ N T+V+ +L+ P ++ T G T L A +
Sbjct: 297 IRG-QDNKTALYWAVEKGNATMVRDILQCNPDTEICT-----KDGETPLIKATKM----R 346
Query: 260 QEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRS 304
+V LL GA + + + + P+H+ G + L +LL R+
Sbjct: 347 NIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRK-LAELLLRN 390
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,615,150
Number of Sequences: 37866
Number of extensions: 660986
Number of successful extensions: 4560
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 264
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 2726
Number of HSP's gapped (non-prelim): 1129
length of query: 313
length of database: 18,247,518
effective HSP length: 102
effective length of query: 211
effective length of database: 14,385,186
effective search space: 3035274246
effective search space used: 3035274246
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.