Search of human proteins with 40806209

Search of human proteins with 40806209

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40806209 WW domain containing E3 ubiquitin protein ligase 2
isoform 3 [Homo sapiens]
         (335 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40806209 WW domain containing E3 ubiquitin protein ligase 2 i...   677   0.0  
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   677   0.0  
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [...   145   6e-35
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   131   7e-31
gi|222352183 neural precursor cell expressed, developmentally do...    64   2e-10
gi|222352088 neural precursor cell expressed, developmentally do...    64   2e-10
gi|222352086 neural precursor cell expressed, developmentally do...    64   2e-10
gi|222352084 neural precursor cell expressed, developmentally do...    64   2e-10
gi|222352082 neural precursor cell expressed, developmentally do...    64   2e-10
gi|114520609 neural precursor cell expressed, developmentally do...    60   2e-09
gi|114520607 neural precursor cell expressed, developmentally do...    60   2e-09
gi|21361472 neural precursor cell expressed, developmentally dow...    60   4e-09
gi|222352094 neural precursor cell expressed, developmentally do...    60   4e-09
gi|222352092 neural precursor cell expressed, developmentally do...    60   4e-09
gi|222352090 neural precursor cell expressed, developmentally do...    60   4e-09
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    54   2e-07
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    54   2e-07
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    54   2e-07
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    54   3e-07
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote...    54   3e-07
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]       53   4e-07
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...    52   1e-06
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    46   4e-05
gi|156546890 WW and C2 domain containing 2 [Homo sapiens]              45   9e-05
gi|163965366 nascent polypeptide-associated complex alpha subuni...    45   1e-04
gi|11141889 WW45 protein [Homo sapiens]                                44   2e-04
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...    44   2e-04
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       44   2e-04
gi|5174751 Yes-associated protein 1, 65kDa isoform 2 [Homo sapiens]    44   3e-04
gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo sap...    44   3e-04

>gi|40806209 WW domain containing E3 ubiquitin protein ligase 2
           isoform 3 [Homo sapiens]
          Length = 335

 Score =  677 bits (1747), Expect = 0.0
 Identities = 335/335 (100%), Positives = 335/335 (100%)

Query: 1   MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI 60
           MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI
Sbjct: 1   MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI 60

Query: 61  GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT 120
           GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT
Sbjct: 61  GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT 120

Query: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180
           LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ
Sbjct: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180

Query: 181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT 240
           PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT
Sbjct: 181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT 240

Query: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300
           TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD
Sbjct: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300

Query: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335
           ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG
Sbjct: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
           isoform 1 [Homo sapiens]
          Length = 870

 Score =  677 bits (1747), Expect = 0.0
 Identities = 335/335 (100%), Positives = 335/335 (100%)

Query: 1   MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI 60
           MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI
Sbjct: 1   MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRI 60

Query: 61  GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT 120
           GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT
Sbjct: 61  GSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLT 120

Query: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180
           LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ
Sbjct: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180

Query: 181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT 240
           PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT
Sbjct: 181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPT 240

Query: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300
           TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD
Sbjct: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPD 300

Query: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335
           ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG
Sbjct: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 24/52 (46%), Positives = 30/52 (57%), Gaps = 7/52 (13%)

Query: 282 EEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLP 333
           E+P T G  Q PA       LP GWE +    G  Y+VDHNT+TTT++ P P
Sbjct: 433 EDPRTQGMIQEPA-------LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 477


>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
           [Homo sapiens]
          Length = 922

 Score =  145 bits (365), Expect = 6e-35
 Identities = 123/383 (32%), Positives = 171/383 (44%), Gaps = 81/383 (21%)

Query: 19  QLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQ 78
           QL + V SAK K          Y EV VDG   E  KT K   SS   W+E + +NVT Q
Sbjct: 19  QLQVTVSSAKLKRKKNWFGTAIYTEVVVDG---EITKTAKSSSSSNPKWDEQLTVNVTPQ 75

Query: 79  SHLDLKVWSCHTLRNE-LLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGEL 137
           + L+ +VWS  TL+ + LLG A+++L   L  +  K+E ++  L L  ENK  +   GEL
Sbjct: 76  TTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLENKNGIAQTGEL 135

Query: 138 TIFLDGPTVDLGNVPN------------GSALTDGSQLPSRDSSGTAVAPEN---RHQPP 182
           T+ LDG  ++  N+ N            G AL +  +  +R ++  AV   N    H P 
Sbjct: 136 TVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPT 195

Query: 183 STNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGH-----SGLANGTVND 237
           ST               S  +    G+ +P + S+     KN+       S  A+ TVN 
Sbjct: 196 STLVQN-----------SCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNG 244

Query: 238 EPTTATDPEEPSVVG------------------VTSPPAAPLSVTPNPNTTSLPAPATPA 279
           E ++    +  SV G                  V  PP   + +T + N   +P+ +   
Sbjct: 245 ESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEI-LTSSENNECIPSTSAEL 303

Query: 280 EGE-----EPSTSGTQQLPAAAQA----PDA----------------LPAGWEQRELPNG 314
           E E     EP TS ++   A   A    PD                 LP+GWEQR+ P+G
Sbjct: 304 ESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHG 363

Query: 315 RVYYVDHNTKTTTWER--PLPPG 335
           R YYVDHNT+TTTWER  PLPPG
Sbjct: 364 RTYYVDHNTRTTTWERPQPLPPG 386



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 20/34 (58%), Positives = 23/34 (67%)

Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335
           LP GWE+R     RVY+V+HNTKTT WE P   G
Sbjct: 458 LPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG 491



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 7/50 (14%)

Query: 282 EEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           E+P T G Q         + LP GWE R    G  Y+VDHNT+TTT++ P
Sbjct: 485 EDPRTQGLQN-------EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
           sapiens]
          Length = 862

 Score =  131 bits (330), Expect = 7e-31
 Identities = 120/347 (34%), Positives = 173/347 (49%), Gaps = 37/347 (10%)

Query: 1   MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQ---PRINSYVEVAVDGLPSETKKTG 57
           M+ + S    +     KSQL + V+SAK K + +    P  + YVEV VDG   ++KKT 
Sbjct: 1   MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGP--SPYVEVTVDG---QSKKTE 55

Query: 58  KRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNE-LLGTASVNLSNVLKNNGGKMEN 116
           K   ++   W + + + VT  S L  +VWS  TL+++ LLGTA++++   LK+N  K+E 
Sbjct: 56  KCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEE 115

Query: 117 MQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPE 176
           + +TL L  + K    + G+L+I LDG  ++   V NG   T  S+  S++  G+    E
Sbjct: 116 VVVTLQLGGD-KEPTETIGDLSICLDGLQLESEVVTNGE--TTCSESASQNDDGSRSKDE 172

Query: 177 NRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGAR------SRHRQPVKNSGHSGL 230
            R    STN  G        +G + R +   G  SP         SR  +P +    +  
Sbjct: 173 TR---VSTN--GSDDPEDAGAGENRRVS---GNNSPSLSNGGFKPSRPPRPSRPPPPTPR 224

Query: 231 ANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQ 290
              +VN  P+ AT   + S  G + PP    + T    T+ L  P T + G     SG +
Sbjct: 225 RPASVNGSPS-ATSESDGSSTG-SLPPTNTNTNTSEGATSGLIIPLTISGG-----SGPR 277

Query: 291 QLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWER--PLPPG 335
            L    QAP  LP GWEQR   +GRVYYVDH  K TTW+R  PLPPG
Sbjct: 278 PLNPVTQAP--LPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPG 322



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 25/53 (47%), Positives = 32/53 (60%), Gaps = 5/53 (9%)

Query: 288 GTQQLPAAAQAPD-----ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPG 335
           G Q L A +Q+ +      LP GWE+R   NGRVY+V+HNT+ T WE P   G
Sbjct: 380 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQG 432



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 16/30 (53%), Positives = 20/30 (66%)

Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           LP GWE R   +G  Y+VDHN +TTT+  P
Sbjct: 439 LPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468


>gi|222352183 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 50/175 (28%), Positives = 70/175 (40%), Gaps = 37/175 (21%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185

Query: 249 SVVGVTSPPAAPLSVTPNPNTTS---------------------------LPAPATPAEG 281
               ++   +  L +TP+ N                              LP P+ PA  
Sbjct: 186 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGR 241

Query: 282 EEPST--SGTQQLPAAA--QAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
              ST   G +  P+ A       LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 242 ARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 296



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 30/193 (15%)

Query: 166 RDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTT-----------PATGEQSPGA 214
           R  S T    E  H PP +    GR+R+   +G    T            P+  E+   A
Sbjct: 218 RSCSVTDAVAEQGHLPPPS-APAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDA 276

Query: 215 RSRH------------RQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AA 259
           + R              +P+      G A+G+  +      +P+      ++SP    +A
Sbjct: 277 KGRTYYVNHNNRTTTWTRPIMQLAEDG-ASGSATNSNNHLIEPQIRRPRSLSSPTVTLSA 335

Query: 260 PLS-VTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYY 318
           PL     +P   ++    +  +  +PS   + + P        LP GWE R  PNGR ++
Sbjct: 336 PLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFF 394

Query: 319 VDHNTKTTTWERP 331
           +DHNTKTTTWE P
Sbjct: 395 IDHNTKTTTWEDP 407



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 57  DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 344 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 402

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 403 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458


>gi|222352088 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 50/175 (28%), Positives = 70/175 (40%), Gaps = 37/175 (21%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 240 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 298

Query: 249 SVVGVTSPPAAPLSVTPNPNTTS---------------------------LPAPATPAEG 281
               ++   +  L +TP+ N                              LP P+ PA  
Sbjct: 299 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGR 354

Query: 282 EEPST--SGTQQLPAAA--QAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
              ST   G +  P+ A       LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 355 ARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 409



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 30/193 (15%)

Query: 166 RDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTT-----------PATGEQSPGA 214
           R  S T    E  H PP +    GR+R+   +G    T            P+  E+   A
Sbjct: 331 RSCSVTDAVAEQGHLPPPS-APAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDA 389

Query: 215 RSRH------------RQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AA 259
           + R              +P+      G A+G+  +      +P+      ++SP    +A
Sbjct: 390 KGRTYYVNHNNRTTTWTRPIMQLAEDG-ASGSATNSNNHLIEPQIRRPRSLSSPTVTLSA 448

Query: 260 PLS-VTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYY 318
           PL     +P   ++    +  +  +PS   + + P        LP GWE R  PNGR ++
Sbjct: 449 PLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFF 507

Query: 319 VDHNTKTTTWERP 331
           +DHNTKTTTWE P
Sbjct: 508 IDHNTKTTTWEDP 520



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 170 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 457 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 515

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 516 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 571


>gi|222352086 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 50/175 (28%), Positives = 70/175 (40%), Gaps = 37/175 (21%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 248 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 306

Query: 249 SVVGVTSPPAAPLSVTPNPNTTS---------------------------LPAPATPAEG 281
               ++   +  L +TP+ N                              LP P+ PA  
Sbjct: 307 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGR 362

Query: 282 EEPST--SGTQQLPAAA--QAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
              ST   G +  P+ A       LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 363 ARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 417



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 30/193 (15%)

Query: 166 RDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTT-----------PATGEQSPGA 214
           R  S T    E  H PP +    GR+R+   +G    T            P+  E+   A
Sbjct: 339 RSCSVTDAVAEQGHLPPPS-APAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDA 397

Query: 215 RSRH------------RQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AA 259
           + R              +P+      G A+G+  +      +P+      ++SP    +A
Sbjct: 398 KGRTYYVNHNNRTTTWTRPIMQLAEDG-ASGSATNSNNHLIEPQIRRPRSLSSPTVTLSA 456

Query: 260 PLS-VTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYY 318
           PL     +P   ++    +  +  +PS   + + P        LP GWE R  PNGR ++
Sbjct: 457 PLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFF 515

Query: 319 VDHNTKTTTWERP 331
           +DHNTKTTTWE P
Sbjct: 516 IDHNTKTTTWEDP 528



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 178 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 465 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 523

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 524 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 579


>gi|222352084 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 50/175 (28%), Positives = 70/175 (40%), Gaps = 37/175 (21%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185

Query: 249 SVVGVTSPPAAPLSVTPNPNTTS---------------------------LPAPATPAEG 281
               ++   +  L +TP+ N                              LP P+ PA  
Sbjct: 186 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGR 241

Query: 282 EEPST--SGTQQLPAAA--QAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
              ST   G +  P+ A       LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 242 ARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 296



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 30/193 (15%)

Query: 166 RDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTT-----------PATGEQSPGA 214
           R  S T    E  H PP +    GR+R+   +G    T            P+  E+   A
Sbjct: 218 RSCSVTDAVAEQGHLPPPS-APAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDA 276

Query: 215 RSRH------------RQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AA 259
           + R              +P+      G A+G+  +      +P+      ++SP    +A
Sbjct: 277 KGRTYYVNHNNRTTTWTRPIMQLAEDG-ASGSATNSNNHLIEPQIRRPRSLSSPTVTLSA 335

Query: 260 PLS-VTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYY 318
           PL     +P   ++    +  +  +PS   + + P        LP GWE R  PNGR ++
Sbjct: 336 PLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFF 394

Query: 319 VDHNTKTTTWERP 331
           +DHNTKTTTWE P
Sbjct: 395 IDHNTKTTTWEDP 407



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 57  DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 344 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 402

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 403 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458


>gi|222352082 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 50/175 (28%), Positives = 70/175 (40%), Gaps = 37/175 (21%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185

Query: 249 SVVGVTSPPAAPLSVTPNPNTTS---------------------------LPAPATPAEG 281
               ++   +  L +TP+ N                              LP P+ PA  
Sbjct: 186 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGR 241

Query: 282 EEPST--SGTQQLPAAA--QAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
              ST   G +  P+ A       LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 242 ARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 296



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 30/193 (15%)

Query: 166 RDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTT-----------PATGEQSPGA 214
           R  S T    E  H PP +    GR+R+   +G    T            P+  E+   A
Sbjct: 218 RSCSVTDAVAEQGHLPPPS-APAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDA 276

Query: 215 RSRH------------RQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AA 259
           + R              +P+      G A+G+  +      +P+      ++SP    +A
Sbjct: 277 KGRTYYVNHNNRTTTWTRPIMQLAEDG-ASGSATNSNNHLIEPQIRRPRSLSSPTVTLSA 335

Query: 260 PLS-VTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYY 318
           PL     +P   ++    +  +  +PS   + + P        LP GWE R  PNGR ++
Sbjct: 336 PLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFF 394

Query: 319 VDHNTKTTTWERP 331
           +DHNTKTTTWE P
Sbjct: 395 IDHNTKTTTWEDP 407



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 57  DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 344 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 402

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 403 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458


>gi|114520609 neural precursor cell expressed, developmentally
           down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 29/62 (46%), Positives = 34/62 (54%)

Query: 270 TSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWE 329
           TS  + A P      S SG Q    +      LP GWE R  PNGR +++DHNTKTTTWE
Sbjct: 391 TSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE 450

Query: 330 RP 331
            P
Sbjct: 451 DP 452



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 20/40 (50%), Positives = 26/40 (65%)

Query: 292 LPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           LP        LP GWE+++   GR YYVDHN++TTTW +P
Sbjct: 340 LPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKP 379



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 32/79 (40%), Positives = 40/79 (50%), Gaps = 6/79 (7%)

Query: 261 LSVTPNPNTT-SLPAPATPAEGEEPSTSGTQQLPAAA-----QAPDALPAGWEQRELPNG 314
           L +T  P T+ S    A  AE  EP      Q  AA      Q P  LP GWE+R+   G
Sbjct: 146 LKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILG 205

Query: 315 RVYYVDHNTKTTTWERPLP 333
           R YYV+H ++ T W+RP P
Sbjct: 206 RTYYVNHESRRTQWKRPTP 224



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 16/30 (53%), Positives = 22/30 (73%)

Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           LP GWE+R   +GR++Y++HN K T WE P
Sbjct: 475 LPPGWEERTHTDGRIFYINHNIKRTQWEDP 504


>gi|114520607 neural precursor cell expressed, developmentally
           down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 29/62 (46%), Positives = 34/62 (54%)

Query: 270 TSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWE 329
           TS  + A P      S SG Q    +      LP GWE R  PNGR +++DHNTKTTTWE
Sbjct: 738 TSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWE 797

Query: 330 RP 331
            P
Sbjct: 798 DP 799



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 20/40 (50%), Positives = 26/40 (65%)

Query: 292 LPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           LP        LP GWE+++   GR YYVDHN++TTTW +P
Sbjct: 687 LPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKP 726



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 19/37 (51%), Positives = 25/37 (67%)

Query: 297 QAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLP 333
           Q P  LP GWE+R+   GR YYV+H ++ T W+RP P
Sbjct: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTP 571



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 16/30 (53%), Positives = 22/30 (73%)

Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           LP GWE+R   +GR++Y++HN K T WE P
Sbjct: 822 LPPGWEERTHTDGRIFYINHNIKRTQWEDP 851


>gi|21361472 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 45/155 (29%), Positives = 68/155 (43%), Gaps = 17/155 (10%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 248 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 306

Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPA-----PATPAEGEEPSTSGTQQ--LP----AAAQ 297
               ++   +  L +TP+ N     +     P++       + +  +Q  LP    A   
Sbjct: 307 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVH 362

Query: 298 APDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
               LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 363 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 397



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 49/175 (28%), Positives = 70/175 (40%), Gaps = 14/175 (8%)

Query: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
           R  S T    E  H PP +  +     G  S       A  RT            +R   
Sbjct: 339 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 398

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
            +   G SG A  + N       +P+      ++SP    +APL     +P   ++    
Sbjct: 399 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 454

Query: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  +  +PS   + + P        LP GWE R  PNGR +++DHNTKTTTWE P
Sbjct: 455 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 508



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 178 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 445 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 503

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 504 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 559


>gi|222352094 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 45/155 (29%), Positives = 68/155 (43%), Gaps = 17/155 (10%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185

Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPA-----PATPAEGEEPSTSGTQQ--LP----AAAQ 297
               ++   +  L +TP+ N     +     P++       + +  +Q  LP    A   
Sbjct: 186 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVH 241

Query: 298 APDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
               LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 242 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 276



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 49/175 (28%), Positives = 70/175 (40%), Gaps = 14/175 (8%)

Query: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
           R  S T    E  H PP +  +     G  S       A  RT            +R   
Sbjct: 218 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 277

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
            +   G SG A  + N       +P+      ++SP    +APL     +P   ++    
Sbjct: 278 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 333

Query: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  +  +PS   + + P        LP GWE R  PNGR +++DHNTKTTTWE P
Sbjct: 334 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 387



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 57  DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 324 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 382

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 383 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 438


>gi|222352092 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 45/155 (29%), Positives = 68/155 (43%), Gaps = 17/155 (10%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 127 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 185

Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPA-----PATPAEGEEPSTSGTQQ--LP----AAAQ 297
               ++   +  L +TP+ N     +     P++       + +  +Q  LP    A   
Sbjct: 186 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVH 241

Query: 298 APDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
               LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 242 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 276



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 49/175 (28%), Positives = 70/175 (40%), Gaps = 14/175 (8%)

Query: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
           R  S T    E  H PP +  +     G  S       A  RT            +R   
Sbjct: 218 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 277

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
            +   G SG A  + N       +P+      ++SP    +APL     +P   ++    
Sbjct: 278 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 333

Query: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  +  +PS   + + P        LP GWE R  PNGR +++DHNTKTTTWE P
Sbjct: 334 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 387



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 57  DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 324 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 382

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 383 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 438


>gi|222352090 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 45/155 (29%), Positives = 68/155 (43%), Gaps = 17/155 (10%)

Query: 190 RSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLANGTVNDEPTTATDPEEP 248
           R R+ RH        P+ G   P       + V  +G S GLA       P + T P+E 
Sbjct: 240 RFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE- 298

Query: 249 SVVGVTSPPAAPLSVTPNPNTTSLPA-----PATPAEGEEPSTSGTQQ--LP----AAAQ 297
               ++   +  L +TP+ N     +     P++       + +  +Q  LP    A   
Sbjct: 299 ----LSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYVH 354

Query: 298 APDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
               LP+GWE+R+   GR YYV+HN +TTTW RP+
Sbjct: 355 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPI 389



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 49/175 (28%), Positives = 70/175 (40%), Gaps = 14/175 (8%)

Query: 166 RDSSGTAVAPENRHQPPSTNCF-----GGRSRTHRHSGASARTTPATGEQSPGARSRHRQ 220
           R  S T    E  H PP +  +     G  S       A  RT            +R   
Sbjct: 331 RSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 390

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPP---AAPLS-VTPNPNTTSLPAPA 276
            +   G SG A  + N       +P+      ++SP    +APL     +P   ++    
Sbjct: 391 QLAEDGASGSATNSNNH----LIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTL 446

Query: 277 TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  +  +PS   + + P        LP GWE R  PNGR +++DHNTKTTTWE P
Sbjct: 447 SNPQSPQPSPYNSPK-PQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDP 500



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 5/52 (9%)

Query: 280 EGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +  + ++   ++LP     P  LP GWE++    GR YYV+HN +TT W RP
Sbjct: 170 DSNDSASQHQEELP-----PPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 6/116 (5%)

Query: 221 PVKNSGHSGLANGTVNDEPTTATDPE-EPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPA 279
           PV+ +    L+N   + +P+    P+ +  V     PP   + + PN     +       
Sbjct: 437 PVRRAVKDTLSNPQ-SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTT 495

Query: 280 EGEEPSTSGTQQLPAAAQAPD----ALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
             E+P       + +           LP GWE+R   +GR +Y+DHN+K T WE P
Sbjct: 496 TWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDP 551


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 8/124 (6%)

Query: 209 EQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPN 268
           +QS   R++    ++N+G     N   +D P   +     S  G         +  P  N
Sbjct: 215 KQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADS--GEQEEHTLQETALPPVN 272

Query: 269 TTSLPAPATPAEGEEPSTSGTQQLPAAAQAP-DALPAGWEQRELPNGRVYYVDHNTKTTT 327
           ++ + AP T     +PS    Q LP +A+     LP  WE     NG VY++DHNTKTT+
Sbjct: 273 SSIIAAPIT-----DPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTS 327

Query: 328 WERP 331
           W  P
Sbjct: 328 WLDP 331



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 16/31 (51%), Positives = 21/31 (67%)

Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
           LPAGWE+ E P   +YYVDH  + T +E P+
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPV 391


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 8/124 (6%)

Query: 209 EQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPN 268
           +QS   R++    ++N+G     N   +D P   +     S  G         +  P  N
Sbjct: 215 KQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADS--GEQEEHTLQETALPPVN 272

Query: 269 TTSLPAPATPAEGEEPSTSGTQQLPAAAQAP-DALPAGWEQRELPNGRVYYVDHNTKTTT 327
           ++ + AP T     +PS    Q LP +A+     LP  WE     NG VY++DHNTKTT+
Sbjct: 273 SSIIAAPIT-----DPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTS 327

Query: 328 WERP 331
           W  P
Sbjct: 328 WLDP 331



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 16/31 (51%), Positives = 21/31 (67%)

Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
           LPAGWE+ E P   +YYVDH  + T +E P+
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPV 391


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 8/124 (6%)

Query: 209 EQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPN 268
           +QS   R++    ++N+G     N   +D P   +     S  G         +  P  N
Sbjct: 215 KQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADS--GEQEEHTLQETALPPVN 272

Query: 269 TTSLPAPATPAEGEEPSTSGTQQLPAAAQAP-DALPAGWEQRELPNGRVYYVDHNTKTTT 327
           ++ + AP T     +PS    Q LP +A+     LP  WE     NG VY++DHNTKTT+
Sbjct: 273 SSIIAAPIT-----DPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTS 327

Query: 328 WERP 331
           W  P
Sbjct: 328 WLDP 331



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 16/31 (51%), Positives = 21/31 (67%)

Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
           LPAGWE+ E P   +YYVDH  + T +E P+
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPV 391


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
           containing 2 [Homo sapiens]
          Length = 1455

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 42/136 (30%), Positives = 58/136 (42%), Gaps = 13/136 (9%)

Query: 207 TGEQSPGAR-SRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVG---VTSPPAAP-- 260
           T +  PGA  S   +  +N   S +   ++  EP    + E P V G   V +P ++   
Sbjct: 200 TDQILPGATPSAEGKRKRNKSVSNMEKASI--EPPEEEEEERPVVNGNGVVVTPESSEHE 257

Query: 261 -LSVTPNPNTTSLPAPAT----PAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGR 315
             S   +    S P PA     P E +E         P   + PD LP  WE      G 
Sbjct: 258 DKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGE 317

Query: 316 VYYVDHNTKTTTWERP 331
           VY++DHNTKTT+W  P
Sbjct: 318 VYFIDHNTKTTSWLDP 333



 Score = 33.9 bits (76), Expect = 0.21
 Identities = 26/100 (26%), Positives = 38/100 (38%), Gaps = 15/100 (15%)

Query: 238 EPTTATDPEEPSVVG-----VTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQL 292
           +PT   D EEP  +        +       +  N  TTS   P    + + P      +L
Sbjct: 291 KPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENEL 350

Query: 293 PAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
           P           GWE+ + P    YYVDH  + T +E P+
Sbjct: 351 PY----------GWEKIDDPIYGTYYVDHINRRTQFENPV 380


>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
           ligase 2 [Homo sapiens]
          Length = 1572

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 37/122 (30%), Positives = 50/122 (40%), Gaps = 25/122 (20%)

Query: 213 GARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSL 272
           GA +    P +  G +G A GT       AT  EE +  G  +    PL   P       
Sbjct: 745 GAAAAAESPPQEEGSAGEAQGTCEG----ATAQEEGATGGSQANGHQPLRSLP------- 793

Query: 273 PAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPL 332
                         S  Q +    +  +ALP  WE R   +GR++YVDH  +TTTW+RP 
Sbjct: 794 --------------SVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPT 839

Query: 333 PP 334
            P
Sbjct: 840 AP 841



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 15/33 (45%), Positives = 22/33 (66%)

Query: 302  LPAGWEQRELPNGRVYYVDHNTKTTTWERPLPP 334
            LP GWE +    G+ ++VDHN++TTT+  P  P
Sbjct: 987  LPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLP 1019


>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
          Length = 1606

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 43/162 (26%), Positives = 69/162 (42%), Gaps = 18/162 (11%)

Query: 183 STNCFGGR---SRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEP 239
           S +C+ G    S T   S  SA+ + +T   S           ++   S + +  ++ E 
Sbjct: 704 SPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDS-MQSPELDPES 762

Query: 240 TTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQ---QLPAAA 296
           T    P +  +      P+  +  +P    + +  P+   EGE P    +Q   QLP+  
Sbjct: 763 TNGAGPWQDELAA----PSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLR 818

Query: 297 QA-------PDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
                     + LP  WE R   +GRV+YVDH  +TTTW+RP
Sbjct: 819 PEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860



 Score = 35.0 bits (79), Expect = 0.094
 Identities = 14/33 (42%), Positives = 21/33 (63%)

Query: 302  LPAGWEQRELPNGRVYYVDHNTKTTTWERPLPP 334
            LP GWE +    G+ ++VDHN++ TT+  P  P
Sbjct: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIP 1052


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
           sapiens]
          Length = 748

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 24/70 (34%), Positives = 36/70 (51%)

Query: 265 PNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTK 324
           PN N T         +  +   +G Q +  +    + LP GWE+R   +GR+ Y++H T+
Sbjct: 122 PNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITR 181

Query: 325 TTTWERPLPP 334
           TT WERP  P
Sbjct: 182 TTQWERPTRP 191



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 17/30 (56%), Positives = 20/30 (66%)

Query: 302 LPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           LP GWE R    GRVY+VDHN +TT +  P
Sbjct: 299 LPPGWEIRNTATGRVYFVDHNNRTTQFTDP 328



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 28/98 (28%), Positives = 36/98 (36%), Gaps = 26/98 (26%)

Query: 255 SPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQ----------------- 297
           S P  PLS   + NT        P  G   +T G    P  A+                 
Sbjct: 196 SSPGRPLSCFVDENT--------PISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHL 247

Query: 298 -APDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPP 334
             P  LP G+EQR    G+VY++   T  +TW  P  P
Sbjct: 248 HTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP 285


>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
            sapiens]
          Length = 1393

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 39/150 (26%), Positives = 62/150 (41%), Gaps = 23/150 (15%)

Query: 194  HRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGV 253
            H  +  +  TTP++ E           P +N   + LAN      PT +T+  E +    
Sbjct: 964  HGETTVNEDTTPSSAE-----------PTENGERTPLANENTTTSPTESTEHGERTANEK 1012

Query: 254  TSP-PAAPLSV---TPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQR 309
            T+P PA P      TP+ N  ++P+PA P E EE + S  +    +   P       E+ 
Sbjct: 1013 TTPSPAEPTEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKP---TEHGEKT 1069

Query: 310  ELPNGRVYY-----VDHNTKTTTWERPLPP 334
             L N ++        +H  KTT+    + P
Sbjct: 1070 TLANEKITLSPEGPTEHGAKTTSANEKITP 1099



 Score = 38.5 bits (88), Expect = 0.009
 Identities = 39/155 (25%), Positives = 63/155 (40%), Gaps = 22/155 (14%)

Query: 158  TDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPAT------GEQS 211
            T  S  P+ +   T +A EN    P+       S  H    A+ +TTP+       GE++
Sbjct: 974  TPSSAEPTENGERTPLANENTTTSPT------ESTEHGERTANEKTTPSPAEPTEHGERT 1027

Query: 212  PGARSRH-RQPVKNSGHSGL---ANGTVNDEPTTATDPEEPSVVG---VTSPPAAPL--- 261
            P A  +    P K + H  +   AN      P   T+  E + +    +T  P  P    
Sbjct: 1028 PSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTLANEKITLSPEGPTEHG 1087

Query: 262  SVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAA 296
            + T + N    P+ A P E  E +TS   ++ ++A
Sbjct: 1088 AKTTSANEKITPSLAKPTEHGERTTSPNDKITSSA 1122



 Score = 36.2 bits (82), Expect = 0.042
 Identities = 46/198 (23%), Positives = 71/198 (35%), Gaps = 23/198 (11%)

Query: 121 LNLQTENKGSVVSGGELTIFLDGPTVDLG------NVPNGSALTDGSQLPSRDSSGTAVA 174
           L   T+N    +S  ELT  L  PT   G      N P+ +  T+  +  + +++  + A
Sbjct: 262 LTKTTKNIQETISANELTQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPA 321

Query: 175 P--ENRHQPPSTNC--FGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGL 230
              ENR +  + N   F      +R   A+  TT    E +        +    S     
Sbjct: 322 EPIENRERTANENTAPFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPT 381

Query: 231 ANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSV------------TPNPNTTSLPAPATP 278
            +G       T   P EP+  G  +P A   +             TP  N  + P+PA P
Sbjct: 382 EHGERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEP 441

Query: 279 AEGEEPSTSGTQQLPAAA 296
            E  E  T+     P+ A
Sbjct: 442 TENRE-RTANENTTPSPA 458



 Score = 35.8 bits (81), Expect = 0.055
 Identities = 45/184 (24%), Positives = 69/184 (37%), Gaps = 27/184 (14%)

Query: 115 ENMQLTLNLQTE-NKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAV 173
           EN + T N +T  +       G+ T F +  T            T  S  P+     T +
Sbjct: 481 ENRETTANEKTTPSPAEPTENGQRTPFANEKT------------TSSSAEPTEHGERTPL 528

Query: 174 APENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHS-GLAN 232
           A EN    P+          +R   A+ +TTP+  E +       R P+ N   +  LA 
Sbjct: 529 ANENTTPSPA------EPTENRERTANEKTTPSPAEPTENG---DRTPLANEKTTPSLAE 579

Query: 233 GTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQL 292
            T N + T   + +  S    ++ P      TP  N  + P+PA P E  E  T+     
Sbjct: 580 PTENGQRTPFANEKTTSS---SAEPTEHEERTPLANENTTPSPAEPTENRE-RTANENTT 635

Query: 293 PAAA 296
           P+ A
Sbjct: 636 PSPA 639



 Score = 31.2 bits (69), Expect = 1.4
 Identities = 39/157 (24%), Positives = 56/157 (35%), Gaps = 29/157 (18%)

Query: 158 TDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSR 217
           T  S   +     T +A EN    P+          +R   A+  TTP     SP   + 
Sbjct: 414 TSSSAESTEHGERTPLANENTTPSPA------EPTENRERTANENTTP-----SPAGPTE 462

Query: 218 HRQPVKNSGHS-GLANGTVNDEPT----TATDPEEPSVVGVTSP------------PAAP 260
           +R+   N   +      T N E T    T   P EP+  G  +P            P   
Sbjct: 463 NRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEH 522

Query: 261 LSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQ 297
              TP  N  + P+PA P E  E  T+  +  P+ A+
Sbjct: 523 GERTPLANENTTPSPAEPTENRE-RTANEKTTPSPAE 558


>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
          Length = 1192

 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 20/48 (41%), Positives = 29/48 (60%), Gaps = 8/48 (16%)

Query: 284 PSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           P  +G+ QLP        LP GWE+    +G+V+Y+DHNT+ T+W  P
Sbjct: 2   PRRAGSGQLP--------LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41



 Score = 37.0 bits (84), Expect = 0.025
 Identities = 21/49 (42%), Positives = 24/49 (48%)

Query: 283 EPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +P    T+ L  A    D LP GWE    P   VYY+DH  KTT  E P
Sbjct: 40  DPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88


>gi|163965366 nascent polypeptide-associated complex alpha subunit
           isoform a [Homo sapiens]
          Length = 2078

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 50/189 (26%), Positives = 70/189 (37%), Gaps = 39/189 (20%)

Query: 144 PTVDLGNVPNGSALTDGSQLPSRDSS-GTAVAPENRHQPPSTNCFGGRSRTHRHSGASAR 202
           PT D G     S+    + L    S  G +V+P+ +  P                G++  
Sbjct: 771 PTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTK-------------KGSAGP 817

Query: 203 TTPATGEQSPGARSRHRQPVKNS--GHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAA- 259
            TP     SP +      PV+ S    + L+     D P T   P  PS  G  +P A  
Sbjct: 818 DTPIGNLSSPVS------PVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVT 871

Query: 260 ---------PLSVTPNPNTTSLP----APATPAEGEEPSTSGTQQLPAAAQ---APDALP 303
                    P   TP P+  +LP     PATPA  + P+ S T   P  A+   AP  +P
Sbjct: 872 PLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIP 931

Query: 304 AGWEQRELP 312
           A    +  P
Sbjct: 932 ASPSPKGAP 940



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 43/179 (24%), Positives = 55/179 (30%), Gaps = 18/179 (10%)

Query: 152  PNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQS 211
            P G+  T  +  PS        +P+     P+      +      S   A TTPA    S
Sbjct: 1191 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS 1250

Query: 212  PGARSRHRQP-----------------VKNSGHSGLANGTVNDEPTTATDPEEPSVVGVT 254
            P        P                 +    H G  N  V   P+    P      G  
Sbjct: 1251 PKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAP 1310

Query: 255  SPPAA-PLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELP 312
            +PPAA P S   +P T       TP     PS  GT  LPA   +    P     +E P
Sbjct: 1311 TPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGP 1369



 Score = 37.4 bits (85), Expect = 0.019
 Identities = 43/157 (27%), Positives = 55/157 (35%), Gaps = 21/157 (13%)

Query: 152  PNGSALTDGSQLPSRDSSGTAVAPENRHQPPST---NCFGGRSRTHRHSGASARTTPATG 208
            P G+     +  PS        +P+    PP+    +  G  + T    GAS  T PA  
Sbjct: 982  PKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGAS--TPPAAT 1039

Query: 209  EQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAA-PLS----- 262
              SP        P       G         P+    P  PS+ G  +PPAA P S     
Sbjct: 1040 PPSPKG-----SPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGP 1094

Query: 263  VTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAP 299
             TP+P    +P  ATP     PS  G    P    AP
Sbjct: 1095 ATPSPKGAPMPPAATP-----PSPKGGLATPPHKGAP 1126



 Score = 34.3 bits (77), Expect = 0.16
 Identities = 44/194 (22%), Positives = 66/194 (34%), Gaps = 24/194 (12%)

Query: 143  GPTVDLGNVPNGSALTDGSQLPSRDSS--GTAVAPENRHQPPSTNCFGGRSRTH------ 194
            GP   +GN+ +  +  + S LP    S  G+  +P   H P   +  G  + +       
Sbjct: 816  GPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSP 875

Query: 195  RHSGASARTTPATG-------EQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEE 247
            +      + TP          ++ P   +  + P  +   S          P     P  
Sbjct: 876  KGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGI--PAS 933

Query: 248  PSVVGVTSPPAA-PLS-----VTPNPNTTSLPAPATPAEGE-EPSTSGTQQLPAAAQAPD 300
            PS  G  +PPAA P S      TP+P     P  ATP   +  P+T   +  P    A  
Sbjct: 934  PSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATP 993

Query: 301  ALPAGWEQRELPNG 314
              P G      P G
Sbjct: 994  PSPKGGPATPSPKG 1007



 Score = 33.9 bits (76), Expect = 0.21
 Identities = 36/158 (22%), Positives = 51/158 (32%), Gaps = 17/158 (10%)

Query: 152  PNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTN--CFGGRSRTHRHSGAS--ARTTPAT 207
            P G+  T  +  PS         P+    PP+       G   T  H GA   A  TP +
Sbjct: 1237 PKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPS 1296

Query: 208  GEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNP 267
             +  P            S   G         P+    P  P   G  +PPA      P+P
Sbjct: 1297 PKGGPAT----------SPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAV---TPPSP 1343

Query: 268  NTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAG 305
              T      TP+    P+T  +++ P    A  +   G
Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGG 1381



 Score = 33.1 bits (74), Expect = 0.36
 Identities = 43/168 (25%), Positives = 68/168 (40%), Gaps = 29/168 (17%)

Query: 143  GPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASAR 202
            GP +   +   G A+      P  D +  AV P +  + P+T             GA+  
Sbjct: 1381 GPAMTPPSPKRGPAIPS----PKGDPTSPAVIPLSPKKAPATPV--------TREGAA-- 1426

Query: 203  TTPATGEQSPGAR---SRHRQPVKNSGHSGLANGTVNDEPT-------TATDPEEPSVVG 252
             TP+ G+ +P A    S  + P  ++   G A  +   +PT       +  +P  P  V 
Sbjct: 1427 -TPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVA 1485

Query: 253  V-TSPPAAPLSVTPNP-NTTSLPAPATPAEGEEPSTSGTQQLPAAAQA 298
              +SP  AP   TP P    +LPA    +  E P+T  +++ P A  A
Sbjct: 1486 TSSSPKKAP--ATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTA 1531



 Score = 32.0 bits (71), Expect = 0.80
 Identities = 35/138 (25%), Positives = 43/138 (31%), Gaps = 7/138 (5%)

Query: 164  PSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVK 223
            PS        +P+    PP+      +      S   A T PA    SP        P  
Sbjct: 971  PSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKG-----SPAA 1025

Query: 224  NSGHSGLANGTVNDEPTTATDPEE-PSVVGVTSPPAAPL-SVTPNPNTTSLPAPATPAEG 281
                 G +       P+    P   P   G  + PAA L S    P T SL    TP   
Sbjct: 1026 TPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAA 1085

Query: 282  EEPSTSGTQQLPAAAQAP 299
              PS  G    P+   AP
Sbjct: 1086 TPPSPKGGPATPSPKGAP 1103



 Score = 30.4 bits (67), Expect = 2.3
 Identities = 21/62 (33%), Positives = 24/62 (38%), Gaps = 1/62 (1%)

Query: 239  PTTATDPEEPSVVGVTSPPAA-PLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQ 297
            P+    P  PS     +PPAA P S    P T S     TP     PS  G    P+   
Sbjct: 948  PSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKG 1007

Query: 298  AP 299
            AP
Sbjct: 1008 AP 1009



 Score = 30.0 bits (66), Expect = 3.0
 Identities = 32/166 (19%), Positives = 49/166 (29%), Gaps = 3/166 (1%)

Query: 152  PNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQS 211
            P G+     +  PS        +P+    PP+      +      S   A T PA    S
Sbjct: 936  PKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPS 995

Query: 212  PGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPA---APLSVTPNPN 268
            P        P        +   +    P     P+  S     +PP+   +P +      
Sbjct: 996  PKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKG 1055

Query: 269  TTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNG 314
              + PA   P+    P+T   +  P    A    P G      P G
Sbjct: 1056 APTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKG 1101



 Score = 30.0 bits (66), Expect = 3.0
 Identities = 31/109 (28%), Positives = 42/109 (38%), Gaps = 8/109 (7%)

Query: 204  TPATGEQSPGARSRHRQP-VKNSGHSGLANGTVNDEPTTATDP---EEPSVVGVTSPPAA 259
            TP     +P ++     P V  S + G  +      P   T P   E P+   VT P   
Sbjct: 1566 TPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPE 1625

Query: 260  PLSVTPNPNTTSLPAPATPAEGEEPSTSG---TQQLPAAA-QAPDALPA 304
                TP P  T    P TP+  ++  TS    T ++ A   QA   LPA
Sbjct: 1626 KGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPA 1674



 Score = 28.5 bits (62), Expect = 8.8
 Identities = 41/177 (23%), Positives = 62/177 (35%), Gaps = 27/177 (15%)

Query: 152  PNGSALTDGSQLPSRDSSGT--AVAPENRHQPPSTNCFGGRS---RTHRHSGASARTTPA 206
            P G+        PS   + T  A  P ++  P + +   G +    T  H G  A T P+
Sbjct: 1329 PKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPS 1388

Query: 207  TGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPN 266
              ++ P   S    P  +     L+       P T      PS   +T P   P+S+   
Sbjct: 1389 P-KRGPAIPSPKGDPT-SPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKA 1446

Query: 267  PNTTS---------------LPAPATPAEGEEP-----STSGTQQLPAAAQAPDALP 303
            P T++               LPA   P+  E P     +TS + +   A  AP   P
Sbjct: 1447 PATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAP 1503


>gi|11141889 WW45 protein [Homo sapiens]
          Length = 383

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 23/53 (43%), Positives = 26/53 (49%), Gaps = 13/53 (24%)

Query: 288 GTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP-----LPPG 335
           G++ LP        LP GW       GR YY+DHNT TT W  P     LPPG
Sbjct: 195 GSEDLP--------LPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPG 239



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 14/35 (40%), Positives = 17/35 (48%)

Query: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPP 334
           + LP GWE+ E      YYVDH  K   +  P  P
Sbjct: 234 EGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAP 268


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
           isoform 2 [Homo sapiens]
          Length = 431

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 18/33 (54%), Positives = 23/33 (69%)

Query: 301 ALPAGWEQRELPNGRVYYVDHNTKTTTWERPLP 333
           ALP GWE +    G  Y+VDHNT+TTT++ P P
Sbjct: 6   ALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRP 38


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 42/155 (27%), Positives = 54/155 (34%), Gaps = 12/155 (7%)

Query: 158 TDGSQLPSRDSSGTAVAPENRHQP--PSTNCFGGRSRTHRHSGASARTTPATGEQSPGAR 215
           T G    SR  +G   AP     P  PS     G  +  R +  S    P      PG +
Sbjct: 526 TQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQ 585

Query: 216 SRHRQPVKNSGHSGLANGTVNDEPTTATDP-----EEPSVVGVTSPPAAPLSVTPNPNTT 270
            R   P K  G +G         P   T P       PS  G    P   L+  P+ +  
Sbjct: 586 QRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQD-- 643

Query: 271 SLPAPATPAEG--EEPSTSGTQQLPAAAQAPDALP 303
            +P PAT A G    P  + +Q L  A   P+  P
Sbjct: 644 -VPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAP 677


>gi|5174751 Yes-associated protein 1, 65kDa isoform 2 [Homo sapiens]
          Length = 454

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 46/191 (24%), Positives = 71/191 (37%), Gaps = 33/191 (17%)

Query: 174 APENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANG 233
           AP+ + QPPS    G    +     A A T  A      G +  H +    +    L N 
Sbjct: 12  APQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNA 71

Query: 234 TVNDE---------------PTTATDPEEP-------SVVGVTSPPAAPLSVTPNPNTTS 271
            +N +               P +   P EP       S    T+    P  V  + +  S
Sbjct: 72  VMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPAS 131

Query: 272 L------PAPATPA---EGEEPSTSGTQQLPAAAQAPD--ALPAGWEQRELPNGRVYYVD 320
           L      P   TP     G   + +      ++ + PD   LPAGWE  +  +G+ Y+++
Sbjct: 132 LQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLN 191

Query: 321 HNTKTTTWERP 331
           H  +TTTW+ P
Sbjct: 192 HIDQTTTWQDP 202



 Score = 30.0 bits (66), Expect = 3.0
 Identities = 18/42 (42%), Positives = 22/42 (52%), Gaps = 2/42 (4%)

Query: 265 PNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQA-PDALPAG 305
           P P     P P+ P +G+ P +   Q  PAA QA P A PAG
Sbjct: 11  PAPQGQGQP-PSQPPQGQGPPSGPGQPAPAATQAAPQAPPAG 51


>gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo
           sapiens]
          Length = 504

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 46/191 (24%), Positives = 71/191 (37%), Gaps = 33/191 (17%)

Query: 174 APENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANG 233
           AP+ + QPPS    G    +     A A T  A      G +  H +    +    L N 
Sbjct: 12  APQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNA 71

Query: 234 TVNDE---------------PTTATDPEEP-------SVVGVTSPPAAPLSVTPNPNTTS 271
            +N +               P +   P EP       S    T+    P  V  + +  S
Sbjct: 72  VMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPAS 131

Query: 272 L------PAPATPA---EGEEPSTSGTQQLPAAAQAPD--ALPAGWEQRELPNGRVYYVD 320
           L      P   TP     G   + +      ++ + PD   LPAGWE  +  +G+ Y+++
Sbjct: 132 LQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLN 191

Query: 321 HNTKTTTWERP 331
           H  +TTTW+ P
Sbjct: 192 HIDQTTTWQDP 202



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 28/97 (28%), Positives = 41/97 (42%), Gaps = 31/97 (31%)

Query: 237 DEPTTATDPEEP--SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPA 294
           D+ TT  DP +   S + VT+P + P+                            Q +  
Sbjct: 194 DQTTTWQDPRKAMLSQMNVTAPTSPPVQ---------------------------QNMMN 226

Query: 295 AAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP 331
           +A  P  LP GWEQ    +G +YY++H  KTT+W  P
Sbjct: 227 SASGP--LPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261



 Score = 30.0 bits (66), Expect = 3.0
 Identities = 18/42 (42%), Positives = 22/42 (52%), Gaps = 2/42 (4%)

Query: 265 PNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQA-PDALPAG 305
           P P     P P+ P +G+ P +   Q  PAA QA P A PAG
Sbjct: 11  PAPQGQGQP-PSQPPQGQGPPSGPGQPAPAATQAAPQAPPAG 51


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.125    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,203,621
Number of Sequences: 37866
Number of extensions: 844928
Number of successful extensions: 7844
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 198
Number of HSP's successfully gapped in prelim test: 683
Number of HSP's that attempted gapping in prelim test: 5205
Number of HSP's gapped (non-prelim): 2711
length of query: 335
length of database: 18,247,518
effective HSP length: 103
effective length of query: 232
effective length of database: 14,347,320
effective search space: 3328578240
effective search space used: 3328578240
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.