Guide to the Human Genome
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Search of human proteins with 40549413

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40549413 glial cell derived neurotrophic factor isoform 3
[Homo sapiens]
         (133 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40549413 glial cell derived neurotrophic factor isoform 3 [Ho...   281   8e-77
gi|40549411 glial cell derived neurotrophic factor isoform 2 pre...   241   1e-64
gi|4503975 glial cell derived neurotrophic factor isoform 1 prep...   241   1e-64
gi|4758826 neurturin preproprotein [Homo sapiens]                     100   4e-22
gi|16950645 neurotrophic factor artemin isoform 2 [Homo sapiens]       70   6e-13
gi|209954781 neurotrophic factor artemin isoform 1 precursor [Ho...    70   6e-13
gi|209954778 neurotrophic factor artemin isoform 3 precursor [Ho...    70   6e-13
gi|209954776 neurotrophic factor artemin isoform 1 precursor [Ho...    70   6e-13
gi|209977029 neurotrophic factor artemin isoform 3 precursor [Ho...    70   6e-13
gi|4758974 persephin precursor [Homo sapiens]                          68   2e-12
gi|7705308 growth differentiation factor 2 [Homo sapiens]              32   0.11 
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...    31   0.25 
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...    29   0.97 
gi|56237021 fibrillin 3 precursor [Homo sapiens]                       28   2.8  
gi|24234690 meiotic recombination 11 homolog A isoform 2 [Homo s...    27   4.8  
gi|5031923 meiotic recombination 11 homolog A isoform 1 [Homo sa...    27   4.8  
gi|21361870 chromosome 11 open reading frame 17 [Homo sapiens]         27   4.8  
gi|116174740 chromosome 11 open reading frame 17 [Homo sapiens]        27   4.8  
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                26   8.2  

>gi|40549413 glial cell derived neurotrophic factor isoform 3 [Homo
           sapiens]
          Length = 133

 Score =  281 bits (720), Expect = 8e-77
 Identities = 133/133 (100%), Positives = 133/133 (100%)

Query: 1   MGCRGCLPGAAPHRVRLPAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKE 60
           MGCRGCLPGAAPHRVRLPAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKE
Sbjct: 1   MGCRGCLPGAAPHRVRLPAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKE 60

Query: 61  ELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYH 120
           ELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYH
Sbjct: 61  ELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYH 120

Query: 121 ILRKHSAKRCGCI 133
           ILRKHSAKRCGCI
Sbjct: 121 ILRKHSAKRCGCI 133


>gi|40549411 glial cell derived neurotrophic factor isoform 2
           precursor [Homo sapiens]
          Length = 185

 Score =  241 bits (615), Expect = 1e-64
 Identities = 115/115 (100%), Positives = 115/115 (100%)

Query: 19  AANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTY 78
           AANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTY
Sbjct: 71  AANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTY 130

Query: 79  DKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 133
           DKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
Sbjct: 131 DKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 185


>gi|4503975 glial cell derived neurotrophic factor isoform 1
           preproprotein [Homo sapiens]
          Length = 211

 Score =  241 bits (615), Expect = 1e-64
 Identities = 115/115 (100%), Positives = 115/115 (100%)

Query: 19  AANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTY 78
           AANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTY
Sbjct: 97  AANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTY 156

Query: 79  DKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 133
           DKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI
Sbjct: 157 DKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 211


>gi|4758826 neurturin preproprotein [Homo sapiens]
          Length = 197

 Score =  100 bits (248), Expect = 4e-22
 Identities = 48/115 (41%), Positives = 72/115 (62%), Gaps = 5/115 (4%)

Query: 20  ANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD 79
           A P   R + R G R     C L  + + V++LGLGY + E ++FRYC+G+C+AA   YD
Sbjct: 87  AGPRRRRARARLGARP----CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYD 142

Query: 80  KILKNLSRNRRLVSDKV-GQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI 133
             L+ L + RRL  ++V  Q CCRP A++D++SFLD +  YH + + SA+ C C+
Sbjct: 143 LGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAHSRYHTVHELSARECACV 197


>gi|16950645 neurotrophic factor artemin isoform 2 [Homo sapiens]
          Length = 237

 Score = 69.7 bits (169), Expect = 6e-13
 Identities = 47/132 (35%), Positives = 66/132 (50%), Gaps = 10/132 (7%)

Query: 11  APHRVRLPAANPENSR-----GKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFR 65
           AP     P+A P   R     G G R +    RGC L +  + V  LGLG+ + E + FR
Sbjct: 106 APPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFR 165

Query: 66  YCSGSCDAAETTYDKILKNLSRNRRL----VSDKVGQACCRPIAFDDDLSFLDDNLVYHI 121
           +CSGSC  A + +D  L +L     L     S  V Q CCRP  + + +SF+D N  +  
Sbjct: 166 FCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY-EAVSFMDVNSTWRT 224

Query: 122 LRKHSAKRCGCI 133
           + + SA  CGC+
Sbjct: 225 VDRLSATACGCL 236


>gi|209954781 neurotrophic factor artemin isoform 1 precursor [Homo
           sapiens]
          Length = 220

 Score = 69.7 bits (169), Expect = 6e-13
 Identities = 47/132 (35%), Positives = 66/132 (50%), Gaps = 10/132 (7%)

Query: 11  APHRVRLPAANPENSR-----GKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFR 65
           AP     P+A P   R     G G R +    RGC L +  + V  LGLG+ + E + FR
Sbjct: 89  APPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFR 148

Query: 66  YCSGSCDAAETTYDKILKNLSRNRRL----VSDKVGQACCRPIAFDDDLSFLDDNLVYHI 121
           +CSGSC  A + +D  L +L     L     S  V Q CCRP  + + +SF+D N  +  
Sbjct: 149 FCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY-EAVSFMDVNSTWRT 207

Query: 122 LRKHSAKRCGCI 133
           + + SA  CGC+
Sbjct: 208 VDRLSATACGCL 219


>gi|209954778 neurotrophic factor artemin isoform 3 precursor [Homo
           sapiens]
          Length = 228

 Score = 69.7 bits (169), Expect = 6e-13
 Identities = 47/132 (35%), Positives = 66/132 (50%), Gaps = 10/132 (7%)

Query: 11  APHRVRLPAANPENSR-----GKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFR 65
           AP     P+A P   R     G G R +    RGC L +  + V  LGLG+ + E + FR
Sbjct: 97  APPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFR 156

Query: 66  YCSGSCDAAETTYDKILKNLSRNRRL----VSDKVGQACCRPIAFDDDLSFLDDNLVYHI 121
           +CSGSC  A + +D  L +L     L     S  V Q CCRP  + + +SF+D N  +  
Sbjct: 157 FCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY-EAVSFMDVNSTWRT 215

Query: 122 LRKHSAKRCGCI 133
           + + SA  CGC+
Sbjct: 216 VDRLSATACGCL 227


>gi|209954776 neurotrophic factor artemin isoform 1 precursor [Homo
           sapiens]
          Length = 220

 Score = 69.7 bits (169), Expect = 6e-13
 Identities = 47/132 (35%), Positives = 66/132 (50%), Gaps = 10/132 (7%)

Query: 11  APHRVRLPAANPENSR-----GKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFR 65
           AP     P+A P   R     G G R +    RGC L +  + V  LGLG+ + E + FR
Sbjct: 89  APPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFR 148

Query: 66  YCSGSCDAAETTYDKILKNLSRNRRL----VSDKVGQACCRPIAFDDDLSFLDDNLVYHI 121
           +CSGSC  A + +D  L +L     L     S  V Q CCRP  + + +SF+D N  +  
Sbjct: 149 FCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY-EAVSFMDVNSTWRT 207

Query: 122 LRKHSAKRCGCI 133
           + + SA  CGC+
Sbjct: 208 VDRLSATACGCL 219


>gi|209977029 neurotrophic factor artemin isoform 3 precursor [Homo
           sapiens]
          Length = 228

 Score = 69.7 bits (169), Expect = 6e-13
 Identities = 47/132 (35%), Positives = 66/132 (50%), Gaps = 10/132 (7%)

Query: 11  APHRVRLPAANPENSR-----GKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFR 65
           AP     P+A P   R     G G R +    RGC L +  + V  LGLG+ + E + FR
Sbjct: 97  APPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFR 156

Query: 66  YCSGSCDAAETTYDKILKNLSRNRRL----VSDKVGQACCRPIAFDDDLSFLDDNLVYHI 121
           +CSGSC  A + +D  L +L     L     S  V Q CCRP  + + +SF+D N  +  
Sbjct: 157 FCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRY-EAVSFMDVNSTWRT 215

Query: 122 LRKHSAKRCGCI 133
           + + SA  CGC+
Sbjct: 216 VDRLSATACGCL 227


>gi|4758974 persephin precursor [Homo sapiens]
          Length = 156

 Score = 68.2 bits (165), Expect = 2e-12
 Identities = 41/103 (39%), Positives = 58/103 (56%), Gaps = 6/103 (5%)

Query: 31  RGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCD-AAETTYDKILKNLSRNR 89
           R +R  +  C L ++ L+V +LGLGY ++E++IFRYC+GSC   A T +   L  L    
Sbjct: 57  RLRRALSGPCQLWSLTLSVAELGLGYASEEKVIFRYCAGSCPRGARTQHGLALARLQGQG 116

Query: 90  RLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGC 132
           R      G  CCRP  +  D++FLDD   +  L + SA  CGC
Sbjct: 117 R----AHGGPCCRPTRY-TDVAFLDDRHRWQRLPQLSAAACGC 154


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score = 32.3 bits (72), Expect = 0.11
 Identities = 31/120 (25%), Positives = 43/120 (35%), Gaps = 25/120 (20%)

Query: 30  RRGQRGKNRGCVLTAIHLNVTDLGLG--------YETKEELIFRYCSGSC-----DAAET 76
           R+   G    C  T++ +N  D+G          YE  E      C G C     D    
Sbjct: 317 RKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYE------CKGGCFFPLADDVTP 370

Query: 77  TYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKH----SAKRCGC 132
           T   I++ L   +     KVG+ACC P           D++    L+ H    S   CGC
Sbjct: 371 TKHAIVQTLVHLK--FPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score = 31.2 bits (69), Expect = 0.25
 Identities = 26/115 (22%), Positives = 46/115 (40%), Gaps = 12/115 (10%)

Query: 28  KGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFR--YCSGSCD-----AAETTYDK 80
           +G+R  +     C   A+H+N  D+G        L +   +C G C+       E T   
Sbjct: 388 QGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHA 447

Query: 81  ILKNLSRNRRLVSDKVGQACCRPIAFDD-DLSFLD--DNLVYHILRKHSAKRCGC 132
           +++ L  +  +  +     CC P       + F+D  +N+VY        + CGC
Sbjct: 448 VIQTLMNS--MDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score = 29.3 bits (64), Expect = 0.97
 Identities = 28/131 (21%), Positives = 53/131 (40%), Gaps = 11/131 (8%)

Query: 12  PHRVRLPAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLG--YETKEELIFRYCSG 69
           PHR        E +  K RR Q  + R C    + ++  D+G      + +     YCSG
Sbjct: 342 PHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSG 401

Query: 70  SCD-----AAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDD-DLSFLDD--NLVYHI 121
           +C      + + +    ++++ R   +V   + + CC P       + F D+  N+V  +
Sbjct: 402 ACQFPMPKSLKPSNHATIQSIVRAVGVVPG-IPEPCCVPEKMSSLSILFFDENKNVVLKV 460

Query: 122 LRKHSAKRCGC 132
               + + C C
Sbjct: 461 YPNMTVESCAC 471


>gi|56237021 fibrillin 3 precursor [Homo sapiens]
          Length = 2809

 Score = 27.7 bits (60), Expect = 2.8
 Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 6/67 (8%)

Query: 37   NRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV 96
            N  CV  A +L V       + ++ + FR+ +G+C       +++  N++R     S  +
Sbjct: 1627 NYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQ------NELAFNVTRKMCCCSYNI 1680

Query: 97   GQACCRP 103
            GQA  RP
Sbjct: 1681 GQAWNRP 1687


>gi|24234690 meiotic recombination 11 homolog A isoform 2 [Homo
           sapiens]
          Length = 680

 Score = 26.9 bits (58), Expect = 4.8
 Identities = 11/19 (57%), Positives = 13/19 (68%)

Query: 19  AANPENSRGKGRRGQRGKN 37
           A N    RG+GRRG RG+N
Sbjct: 565 ATNKGRGRGRGRRGGRGQN 583


>gi|5031923 meiotic recombination 11 homolog A isoform 1 [Homo
           sapiens]
          Length = 708

 Score = 26.9 bits (58), Expect = 4.8
 Identities = 11/19 (57%), Positives = 13/19 (68%)

Query: 19  AANPENSRGKGRRGQRGKN 37
           A N    RG+GRRG RG+N
Sbjct: 565 ATNKGRGRGRGRRGGRGQN 583


>gi|21361870 chromosome 11 open reading frame 17 [Homo sapiens]
          Length = 210

 Score = 26.9 bits (58), Expect = 4.8
 Identities = 11/22 (50%), Positives = 13/22 (59%)

Query: 2  GCRGCLPGAAPHRVRLPAANPE 23
          GC G L   APH  + PAA P+
Sbjct: 47 GCMGVLAREAPHLEKQPAAGPQ 68


>gi|116174740 chromosome 11 open reading frame 17 [Homo sapiens]
          Length = 210

 Score = 26.9 bits (58), Expect = 4.8
 Identities = 11/22 (50%), Positives = 13/22 (59%)

Query: 2  GCRGCLPGAAPHRVRLPAANPE 23
          GC G L   APH  + PAA P+
Sbjct: 47 GCMGVLAREAPHLEKQPAAGPQ 68


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 26.2 bits (56), Expect = 8.2
 Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 11/59 (18%)

Query: 16  RLPAANPENSRGKGRRGQRGKNRGC----VLTAIH-------LNVTDLGLGYETKEELI 63
           R P+    +S G+GR  +RG +  C     L  IH       L V D+   YE  ++L+
Sbjct: 491 RTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLL 549


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.446 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,390,295
Number of Sequences: 37866
Number of extensions: 224344
Number of successful extensions: 679
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 653
Number of HSP's gapped (non-prelim): 19
length of query: 133
length of database: 18,247,518
effective HSP length: 91
effective length of query: 42
effective length of database: 14,801,712
effective search space: 621671904
effective search space used: 621671904
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 56 (26.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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