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Search of human proteins with 40548397
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40548397 NADP-dependent retinol dehydrogenase/reductase
[Homo sapiens]
(319 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 645 0.0
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 645 0.0
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 645 0.0
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 645 0.0
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 296 2e-80
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 295 4e-80
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 284 8e-77
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 274 7e-74
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 188 5e-48
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 188 5e-48
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 188 5e-48
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 169 3e-42
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi... 153 2e-37
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 86 4e-17
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 82 5e-16
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 80 3e-15
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 77 2e-14
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 67 2e-11
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 67 3e-11
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 65 1e-10
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 65 1e-10
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 64 2e-10
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 62 9e-10
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 59 4e-09
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 59 4e-09
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 59 4e-09
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 59 4e-09
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 59 6e-09
gi|40254992 carbonic reductase 4 [Homo sapiens] 57 2e-08
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 55 6e-08
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 645 bits (1663), Expect = 0.0
Identities = 319/319 (100%), Positives = 319/319 (100%)
Query: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC
Sbjct: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
Query: 61 LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA
Sbjct: 61 LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
Query: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
Query: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE
Sbjct: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
Query: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA
Sbjct: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
Query: 301 LQDFLLLKQKAELANPKAV 319
LQDFLLLKQKAELANPKAV
Sbjct: 301 LQDFLLLKQKAELANPKAV 319
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 645 bits (1663), Expect = 0.0
Identities = 319/319 (100%), Positives = 319/319 (100%)
Query: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC
Sbjct: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
Query: 61 LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA
Sbjct: 61 LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
Query: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
Query: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE
Sbjct: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
Query: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA
Sbjct: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
Query: 301 LQDFLLLKQKAELANPKAV 319
LQDFLLLKQKAELANPKAV
Sbjct: 301 LQDFLLLKQKAELANPKAV 319
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 645 bits (1663), Expect = 0.0
Identities = 319/319 (100%), Positives = 319/319 (100%)
Query: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC
Sbjct: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
Query: 61 LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA
Sbjct: 61 LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
Query: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
Query: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE
Sbjct: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
Query: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA
Sbjct: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
Query: 301 LQDFLLLKQKAELANPKAV 319
LQDFLLLKQKAELANPKAV
Sbjct: 301 LQDFLLLKQKAELANPKAV 319
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 645 bits (1663), Expect = 0.0
Identities = 319/319 (100%), Positives = 319/319 (100%)
Query: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC
Sbjct: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
Query: 61 LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA
Sbjct: 61 LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120
Query: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSK 180
Query: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE
Sbjct: 181 YAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGE 240
Query: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA
Sbjct: 241 GYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAA 300
Query: 301 LQDFLLLKQKAELANPKAV 319
LQDFLLLKQKAELANPKAV
Sbjct: 301 LQDFLLLKQKAELANPKAV 319
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 296 bits (758), Expect = 2e-80
Identities = 139/293 (47%), Positives = 204/293 (69%), Gaps = 1/293 (0%)
Query: 16 WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
W R+ ++ + + DKY+FITGCDSGFGNL AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 17 WYRERQV-VSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
Query: 76 RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
RL TV LDVT E++ QWVK VG++GLWGL+NNAG+ + +WL ED ++
Sbjct: 76 RLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLK 135
Query: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
VNL G+I VTL+MLPLV++A+GR++NVSS+ GR+A GGY SKY VE F+D LRR+++
Sbjct: 136 VNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQ 195
Query: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
FGV +S +EPG F+T + + + +E+ W++ IK+ YG+ Y + + +K
Sbjct: 196 HFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLL 255
Query: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308
+ +L+ V +CM+HALTS+ P+T Y+AG DAK F+IPLS++P +L D++L +
Sbjct: 256 NCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTR 308
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 295 bits (755), Expect = 4e-80
Identities = 143/291 (49%), Positives = 202/291 (69%), Gaps = 1/291 (0%)
Query: 16 WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75
W R+ ++ + + DKY+FITGCDSGFG L AR D +G V+AACLTE G+ L+ +TS+
Sbjct: 17 WYRERQV-LSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
Query: 76 RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135
RL TV LDVT E+V AQWVK V +KGLWGL+NNAG+ AP + LT +D+ ++
Sbjct: 76 RLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILD 135
Query: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195
VNL G+I VTL++LPLV++A+GRV+NVSSV GR+++ GGGY SKY VE F+DSLRR++
Sbjct: 136 VNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELS 195
Query: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255
FGV V+ IEPG FKT + + ++ L IW++ SP++K+ YGE ++ + +
Sbjct: 196 YFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQ 255
Query: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
DLS V CM+HAL + P+T Y+AG DAK+ ++P+S+MP L D ++
Sbjct: 256 KCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 284 bits (726), Expect = 8e-77
Identities = 137/293 (46%), Positives = 196/293 (66%), Gaps = 1/293 (0%)
Query: 14 FLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
+ W + L + ++++KY+FITGCDSGFGNL A+ +G V+AAC TE GS L+ +T
Sbjct: 11 YRWFKNCNL-VGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDT 69
Query: 74 SERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREP 133
S RL+T LLDVT E++K AQWV+++VGE+GLW L+NNAGV P +WLT +D+ +
Sbjct: 70 SYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKV 129
Query: 134 IEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRD 193
I VNL GLI VTL+MLP+VK+A+GRV+N+SS GGR+A++GGGY SK+ VE F+DS+RR+
Sbjct: 130 INVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRE 189
Query: 194 MKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
+ FGV V IEPG ++T + + + +WE+L + + YGE Y DKLK
Sbjct: 190 LYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNI 249
Query: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
+ V+ M+HA+ S P+ Y G DAK+ +IPL+ +P + DF+L
Sbjct: 250 MQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFIL 302
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 274 bits (701), Expect = 7e-74
Identities = 137/299 (45%), Positives = 205/299 (68%), Gaps = 4/299 (1%)
Query: 10 ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTAL 69
+L LW + + + ++ ++FITGCDSGFG L A D++GF V+A+CLT SG+ L
Sbjct: 10 LLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDL 68
Query: 70 KAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLED 129
+ S RL T LLD+TDP++V++ A+WV+ V E GL+GL+NNAGV G++ PT WLT +D
Sbjct: 69 QRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD 128
Query: 130 YREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDS 189
++ + VN G I VTL +LPL+++A+GRVIN++SV GRLA GGGY SK+ +E F+DS
Sbjct: 129 FQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDS 188
Query: 190 LRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKL-AIWEQLSPDIKQQYGEGYIEKSLD 248
LRRD+ FG+ VS +EPG F+T + + ++ +EK L A W +L P + YG ++ K L
Sbjct: 189 LRRDVAHFGIRVSIVEPGFFRTPVTN-LESLEKTLQACWARLPPATQAHYGGAFLTKYLK 247
Query: 249 KLKGNKSYV-NMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
+ + + + DL+ V C++HALT+ P+T Y+ G DAK+ W+P S++PA+L D +L
Sbjct: 248 MQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVL 306
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 188 bits (478), Expect = 5e-48
Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)
Query: 25 EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
E + K + +TGCDSGFG A+ KGF V A CL + G L + S+RLRTV
Sbjct: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
Query: 81 LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
L+V E V++ + V++ + EKG+WGL+NNAG+ ++ +LE Y++ EVNL
Sbjct: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
Query: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
+G + +T + LPL+++A+GRV+N+SS+ GR+A Y +K+ VE F+D LR +M
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
Query: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
GV VS +EPG F T+L P ++ I KK+ WE+L +++ YG+ Y ++ + K++
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
Query: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
S + D SPV++ + HALT+ P T Y +W+ ++H+P A+ D + ++
Sbjct: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 188 bits (478), Expect = 5e-48
Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)
Query: 25 EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
E + K + +TGCDSGFG A+ KGF V A CL + G L + S+RLRTV
Sbjct: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
Query: 81 LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
L+V E V++ + V++ + EKG+WGL+NNAG+ ++ +LE Y++ EVNL
Sbjct: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
Query: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
+G + +T + LPL+++A+GRV+N+SS+ GR+A Y +K+ VE F+D LR +M
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
Query: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
GV VS +EPG F T+L P ++ I KK+ WE+L +++ YG+ Y ++ + K++
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
Query: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
S + D SPV++ + HALT+ P T Y +W+ ++H+P A+ D + ++
Sbjct: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 188 bits (478), Expect = 5e-48
Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)
Query: 25 EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80
E + K + +TGCDSGFG A+ KGF V A CL + G L + S+RLRTV
Sbjct: 51 EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
Query: 81 LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138
L+V E V++ + V++ + EKG+WGL+NNAG+ ++ +LE Y++ EVNL
Sbjct: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
Query: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197
+G + +T + LPL+++A+GRV+N+SS+ GR+A Y +K+ VE F+D LR +M
Sbjct: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
Query: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253
GV VS +EPG F T+L P ++ I KK+ WE+L +++ YG+ Y ++ + K++
Sbjct: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
Query: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308
S + D SPV++ + HALT+ P T Y +W+ ++H+P A+ D + ++
Sbjct: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 169 bits (428), Expect = 3e-42
Identities = 107/312 (34%), Positives = 169/312 (54%), Gaps = 15/312 (4%)
Query: 3 FWVLGLL-ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACL 61
FW L L + C ++T ++ + K + +TG D G G+ + D+ GF V A L
Sbjct: 55 FWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL 114
Query: 62 TESGSTA--LKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVL 119
E+G A L+ S RL + +D+T P +K V + ++GLW +INNAGV G
Sbjct: 115 NENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFP 174
Query: 120 APTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGG-----RLAIVGG 174
+ L + DY++ + VN FG + VT LPL++K++GR++NVSS+GG RLA
Sbjct: 175 TDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLA---- 230
Query: 175 GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEK-KLAIWEQLSPD 233
Y SK AV F+ +R ++ +G+ V+ I+PG F TN+A EK + I + L +
Sbjct: 231 SYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAE 290
Query: 234 IKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP 293
+++ YG+ YI + L S + D SPV+ + HA+ + P +Y GK A + WI
Sbjct: 291 VQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYL-WIC 349
Query: 294 LSH-MPAALQDF 304
L+H +P + D+
Sbjct: 350 LAHYLPIGIYDY 361
>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
Length = 405
Score = 153 bits (387), Expect = 2e-37
Identities = 93/280 (33%), Positives = 146/280 (52%), Gaps = 4/280 (1%)
Query: 27 ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET--SERLRTVLLDV 84
+ + + ITGCDSGFG A+ D GF V+A L + A++ T S RLR + +D+
Sbjct: 80 VATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDL 139
Query: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
T P ++ R ++ K GLWGL+NNAG V+A + + +R +EVN FG + +
Sbjct: 140 TKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALEL 199
Query: 145 TLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSC 203
T +LPL++ ++GR++ V S G + G Y SK AV D+ ++ +GV VS
Sbjct: 200 TKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSI 259
Query: 204 IEPGLFKTNLADPVKVIEK-KLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 262
I+PG FKT V EK K + L ++ Q YG+ YIE + + DL+
Sbjct: 260 IQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLT 319
Query: 263 PVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQ 302
PVV+ + AL + P+ Y G+ + + ++P L+
Sbjct: 320 PVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLR 359
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 85.9 bits (211), Expect = 4e-17
Identities = 67/225 (29%), Positives = 106/225 (47%), Gaps = 20/225 (8%)
Query: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPEN 89
K + +TG G G R F G V+ ESG AL+ E + +L DVT ++
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68
Query: 90 VKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNML 149
VK + G L ++NNAG + + + +R+ +E+NL G ++T L
Sbjct: 69 VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126
Query: 150 PLVKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGL 208
P ++K+QG VIN+SS+ G + Y +K AV +L D +GV V+CI PG
Sbjct: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG- 185
Query: 209 FKTNLADPVKVIEKKLAIWEQLS---PDIKQQYGEGYIEKSLDKL 250
N+ P +WE+L+ PD + EG + + L ++
Sbjct: 186 ---NIWTP---------LWEELAALMPDPRATIREGMLAQPLGRM 218
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 82.4 bits (202), Expect = 5e-16
Identities = 66/228 (28%), Positives = 113/228 (49%), Gaps = 23/228 (10%)
Query: 1 MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC 60
+LF LG+ L L +GK + + + ITG SG G A+ F G ++ C
Sbjct: 27 LLFGCLGVFGLFRLLQWVRGKAYLRNAV---VVITGATSGLGKECAKVFYAAGAKLVL-C 82
Query: 61 LTESGSTA-----LKAETSERLRT-----VLLDVTDPENVKRTAQWVKNQVGEKGLWGLI 110
G+ L A + +++T V D+TD + A + G + L+
Sbjct: 83 GRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LV 140
Query: 111 NNAGVP--GVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGG 167
NNAG+ G + T T++ + +E N FG +++T +LP ++K+ QG ++ +SS+ G
Sbjct: 141 NNAGISYRGTIMDT---TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQG 197
Query: 168 RLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLA 214
+++I Y SK+A + F D LR +M+ + + V+ I PG TNL+
Sbjct: 198 KMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 79.7 bits (195), Expect = 3e-15
Identities = 69/257 (26%), Positives = 123/257 (47%), Gaps = 24/257 (9%)
Query: 32 IFITGCDSGFG-NLAARTFD--KKGFHVIAACLTESGSTALKAETSERLRTVL----LDV 84
+ I+GC SG G LA + KK + V+A L+A E L L LDV
Sbjct: 8 VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDV 67
Query: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
E+V + ++ +V L+NNAG+ G++ P + L+L + + N FG + +
Sbjct: 68 CSDESVAQCLSCIQGEVDV-----LVNNAGM-GLVGPLEGLSLAAMQNVFDTNFFGAVRL 121
Query: 145 TLNMLPLVKKA-QGRVINVSSVGGRLAIVGGG-YTPSKYAVEGFNDSLRRDMKAFGVHVS 202
+LP +K+ QG ++ +SSV G ++ Y SK+A+EGF +SL + F + +S
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181
Query: 203 CIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 262
+EPG T + + + +A + P+ + + Y+ S K + ++ +
Sbjct: 182 LVEPGPVVTEFEGKL-LAQVSMAEFPGTDPETLHYFRDLYLPAS------RKLFCSVGQN 234
Query: 263 P--VVECMDHALTSLFP 277
P VV+ + + ++S P
Sbjct: 235 PQDVVQAIVNVISSTRP 251
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 77.4 bits (189), Expect = 2e-14
Identities = 58/212 (27%), Positives = 110/212 (51%), Gaps = 14/212 (6%)
Query: 15 LWTR-KGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAET 73
LW +G+ ++TD +++TG SG G A K G ++ + +K
Sbjct: 35 LWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRC 94
Query: 74 SER-------LRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLT 126
E + + LD+TD + + + V + G + L+NN G+ D +
Sbjct: 95 LENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGGMSQRSLCMD-TS 151
Query: 127 LEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGRLAI-VGGGYTPSKYAVE 184
L+ YR+ IE+N G +S+T +LP ++++ QG+++ V+S+ G +++ + GY SK+A+
Sbjct: 152 LDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALR 211
Query: 185 GFNDSLRRDMKAF-GVHVSCIEPGLFKTNLAD 215
GF + LR ++ + G+ VS I PG ++N+ +
Sbjct: 212 GFFNGLRTELATYPGIIVSNICPGPVQSNIVE 243
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 67.0 bits (162), Expect = 2e-11
Identities = 60/222 (27%), Positives = 107/222 (48%), Gaps = 23/222 (10%)
Query: 5 VLGLLILCGF-----LWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAA 59
+L LLI+C L+ K + + +T + + ITG G G L A F K ++
Sbjct: 10 LLPLLIVCSLESFVKLFIPKRR---KSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLW 66
Query: 60 CLTESG--STALKAE-TSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVP 116
+ + G TA K + ++ T ++D ++ E++ +A+ VK ++G+ + L+NNA
Sbjct: 67 DINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSI--LVNNA--- 121
Query: 117 GVLAPTDWLTLED--YREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGRLAI-V 172
GV+ +D +D + EVN+ T LP + K G ++ V+S G +++
Sbjct: 122 GVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPF 181
Query: 173 GGGYTPSKYAVEGFNDSLRRDMKAF---GVHVSCIEPGLFKT 211
Y SK+A GF+ +L ++ A GV +C+ P T
Sbjct: 182 LLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNT 223
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 66.6 bits (161), Expect = 3e-11
Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 16/197 (8%)
Query: 32 IFITGCDSGFG-NLAAR-TFDKKGFHVIAACLTESGSTALKAETSERL-------RTVLL 82
+ ITGC SG G +LA R D + A L + + E + L T+ L
Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
Query: 83 DVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLI 142
DV D ++V + +V E + L+ NAG+ G+L P + L + ++VN+ G +
Sbjct: 66 DVRDSKSVAAA----RERVTEGRVDVLVCNAGL-GLLGPLEALGEDAVASVLDVNVVGTV 120
Query: 143 SVTLNMLPLVKK-AQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVH 200
+ LP +K+ GRV+ SVGG + + Y SK+A+EG +SL + FGVH
Sbjct: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
Query: 201 VSCIEPGLFKTNLADPV 217
+S IE G T + V
Sbjct: 181 LSLIECGPVHTAFMEKV 197
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 64.7 bits (156), Expect = 1e-10
Identities = 62/225 (27%), Positives = 103/225 (45%), Gaps = 27/225 (12%)
Query: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAACLT----ESGSTALKAET-SERLRTVLLDV 84
K + ITG ++G G AR +G V AC ES ++ ++ +T + ++ LD+
Sbjct: 40 KVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
Query: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
+D ++++ A+ + EK L LINNAGV ++ P T + + + VN G +
Sbjct: 100 SDTKSIRAFAEGFLAE--EKQLHILINNAGV--MMCPYS-KTADGFETHLGVNHLGHFLL 154
Query: 145 TLNMLPLVK-KAQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190
T +L +K A RV+NVSSV + + G Y SK A F L
Sbjct: 155 TYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTREL 214
Query: 191 RRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIK 235
+ ++ GV + PG+ ++ L V+ +W SP +K
Sbjct: 215 AKRLQGTGVTTYAVHPGVVRSEL---VRHSSLLCLLWRLFSPFVK 256
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 64.7 bits (156), Expect = 1e-10
Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 22/224 (9%)
Query: 1 MLFWVLGLLIL---CGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVI 57
+L + GLL + LW++ + +K + IT SG G AR F G ++
Sbjct: 12 LLLGISGLLFIYQEVSRLWSKSA------VQNKVVVITDAISGLGKECARVFHTGGARLV 65
Query: 58 AACLT----ESGSTAL--KAETSERL--RTVLLDVTDPENVKRTAQWVKNQVGEKGLWGL 109
E+ AL A+ S+ + VLLD++D V A+ V + G + L
Sbjct: 66 LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--L 123
Query: 110 INNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP-LVKKAQGRVINVSSVGGR 168
INNA V V P ++LE ++ ++ N FG I++T +LP ++ + G+++ V+++ G+
Sbjct: 124 INNASVK-VKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGK 182
Query: 169 LAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKT 211
I Y SK+A GF D LR +++ + V +S + P ++
Sbjct: 183 FGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 63.5 bits (153), Expect = 2e-10
Identities = 58/220 (26%), Positives = 98/220 (44%), Gaps = 24/220 (10%)
Query: 29 DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE-----RLRTVLLD 83
D+ +TG G G AR ++G V+ T L AE L D
Sbjct: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70
Query: 84 VTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL---TLEDYREPIEVNLFG 140
+++ E++ +++Q G+ INNAG LA D L + +++ VN+
Sbjct: 71 LSNEEDILSMFSAIRSQ--HSGVDICINNAG----LARPDTLLSGSTSGWKDMFNVNVLA 124
Query: 141 LISVTLNMLPLVKKA---QGRVINVSSVGGRLAI---VGGGYTPSKYAVEGFNDSLRRDM 194
L T +K+ G +IN++S+ G + V Y+ +KYAV + LR+++
Sbjct: 125 LSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQEL 184
Query: 195 KAFGVHV--SCIEPGLFKTNLADPV--KVIEKKLAIWEQL 230
+ H+ +CI PG+ +T A + K EK A +EQ+
Sbjct: 185 REAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQM 224
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 61.6 bits (148), Expect = 9e-10
Identities = 51/197 (25%), Positives = 93/197 (47%), Gaps = 15/197 (7%)
Query: 25 EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE---RLRTVL 81
+ + + + ITG G G F K+ ++ + + G AE + +
Sbjct: 32 KSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYV 91
Query: 82 LDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYR--EPIEVNLF 139
+D ++ E + R+ VK +VG+ + ++NNAG + P D L+ +D + EVN+
Sbjct: 92 VDCSNREEIYRSLNQVKKEVGDVTI--VVNNAGT---VYPADLLSTKDEEITKTFEVNIL 146
Query: 140 GLISVTLNMLP-LVKKAQGRVINVSSVGGRLAIVGG-GYTPSKYAVEGFNDSLRRDMKAF 197
G +T +LP ++++ G ++ V+SV G I Y SK+A GF+ L +++A
Sbjct: 147 GHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQAL 206
Query: 198 ---GVHVSCIEPGLFKT 211
G+ SC+ P T
Sbjct: 207 GKTGIKTSCLCPVFVNT 223
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 59.3 bits (142), Expect = 4e-09
Identities = 58/198 (29%), Positives = 83/198 (41%), Gaps = 25/198 (12%)
Query: 34 ITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRT 93
ITG SG G A +G + L SG A + DVT ++V+
Sbjct: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
Query: 94 AQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL------TLEDYREPIEVNLFGLISVTLN 147
K + G + +N AG+ V + T L TLED++ ++VNL G T N
Sbjct: 75 LALAKGKFGRVDV--AVNCAGI-AVASKTYNLKKGQTHTLEDFQRVLDVNLMG----TFN 127
Query: 148 MLPLVKKAQGR-----------VINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMK 195
++ LV G+ +IN +SV VG Y+ SK + G + RD+
Sbjct: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
Query: 196 AFGVHVSCIEPGLFKTNL 213
G+ V I PGLF T L
Sbjct: 188 PIGIRVMTIAPGLFGTPL 205
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 59.3 bits (142), Expect = 4e-09
Identities = 52/206 (25%), Positives = 98/206 (47%), Gaps = 15/206 (7%)
Query: 5 VLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTE- 63
+LGL + + ++ + + E + K + +TG G G A K G HV+ ++
Sbjct: 11 ILGLF-MAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKE 69
Query: 64 ------SGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPG 117
S L A ++ + + D+T E AQ K G L ++N+
Sbjct: 70 TLQKVVSHCLELGAASAHYIAGTMEDMTFAEQF--VAQAGKLMGGLDML--ILNHITNTS 125
Query: 118 VLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGY 176
+ D + R+ +EVN + +T+ LP++K++ G ++ VSS+ G++A + Y
Sbjct: 126 LNLFHD--DIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY 183
Query: 177 TPSKYAVEGFNDSLRRDMKAFGVHVS 202
+ SK+A++GF S+R++ V+VS
Sbjct: 184 SASKFALDGFFSSIRKEYSVSRVNVS 209
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 59.3 bits (142), Expect = 4e-09
Identities = 52/206 (25%), Positives = 98/206 (47%), Gaps = 15/206 (7%)
Query: 5 VLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTE- 63
+LGL + + ++ + + E + K + +TG G G A K G HV+ ++
Sbjct: 11 ILGLF-MAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKE 69
Query: 64 ------SGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPG 117
S L A ++ + + D+T E AQ K G L ++N+
Sbjct: 70 TLQKVVSHCLELGAASAHYIAGTMEDMTFAEQF--VAQAGKLMGGLDML--ILNHITNTS 125
Query: 118 VLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAI-VGGGY 176
+ D + R+ +EVN + +T+ LP++K++ G ++ VSS+ G++A + Y
Sbjct: 126 LNLFHD--DIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAY 183
Query: 177 TPSKYAVEGFNDSLRRDMKAFGVHVS 202
+ SK+A++GF S+R++ V+VS
Sbjct: 184 SASKFALDGFFSSIRKEYSVSRVNVS 209
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 59.3 bits (142), Expect = 4e-09
Identities = 60/203 (29%), Positives = 95/203 (46%), Gaps = 24/203 (11%)
Query: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAACL-TESGS-TALKAETSERLRTVL---LDV 84
K + +TG ++G G A+ ++G V AC E G A + +T+ + VL LD+
Sbjct: 42 KVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDL 101
Query: 85 TDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISV 144
+D ++++ A+ + EK L LINNAGV ++ P T + + I VN G +
Sbjct: 102 SDTKSIRAFAKGFLAE--EKHLHVLINNAGV--MMCPYS-KTADGFEMHIGVNHLGHFLL 156
Query: 145 TLNMLPLVKK-AQGRVINVSSVGGRLAIV-------------GGGYTPSKYAVEGFNDSL 190
T +L +K+ A R++NVSS+ L + G Y SK A F L
Sbjct: 157 THLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQEL 216
Query: 191 RRDMKAFGVHVSCIEPGLFKTNL 213
R +K GV + PG ++ L
Sbjct: 217 ARRLKGSGVTTYSVHPGTVQSEL 239
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 58.9 bits (141), Expect = 6e-09
Identities = 55/207 (26%), Positives = 94/207 (45%), Gaps = 25/207 (12%)
Query: 27 ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAAC----LTESGSTALKAET-SERLRTVL 81
I K + +TG ++G G A ++G ++I AC E+ + ++ ET + +
Sbjct: 36 IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARH 95
Query: 82 LDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGL 141
LD+ ++++ A + + E+ + LINNA GV+ W T + + VN G
Sbjct: 96 LDLASLKSIREFAAKIIEE--EERVDILINNA---GVMRCPHWTTEDGFEMQFGVNHLGH 150
Query: 142 ISVTLNMLPLVK-KAQGRVINVSS---VGGRLAI-----------VGGGYTPSKYAVEGF 186
+T +L +K A R+IN+SS V G + Y SK A+ F
Sbjct: 151 FLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210
Query: 187 NDSLRRDMKAFGVHVSCIEPGLFKTNL 213
L R ++ GV V+ + PG+ +T L
Sbjct: 211 TKELSRRLQGSGVTVNALHPGVARTEL 237
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 57.0 bits (136), Expect = 2e-08
Identities = 45/194 (23%), Positives = 85/194 (43%), Gaps = 9/194 (4%)
Query: 29 DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPE 88
DK + G G G A+ +KG+ + G+ A + DV
Sbjct: 2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEH 61
Query: 89 NVKRTAQWVKNQVGEKGLWGLINNAGV--PGVLAPTDWLTLEDYREPIEVNLFG-LISVT 145
+V+ T + ++ +G L+N AG+ G+L T ED + NL G +++
Sbjct: 62 DVQNTFEELEKHLGRVNF--LVNAAGINRDGLLVRTK---TEDMVSQLHTNLLGSMLTCK 116
Query: 146 LNMLPLVKKAQGRVINVSSVGGRLAIVGGG-YTPSKYAVEGFNDSLRRDMKAFGVHVSCI 204
M ++++ G ++NV S+ G G Y+ SK + GF+ +L +++ + V+ +
Sbjct: 117 AAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVV 176
Query: 205 EPGLFKTNLADPVK 218
PG T++ +K
Sbjct: 177 APGFVHTDMTKDLK 190
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 55.5 bits (132), Expect = 6e-08
Identities = 46/195 (23%), Positives = 88/195 (45%), Gaps = 2/195 (1%)
Query: 27 ITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTD 86
+ ++ +TG SG G AR + G HV+ + + A+ +V V
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCH 93
Query: 87 PENVKRTAQWVKNQVGE-KGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVT 145
+ Q V + G+ L+ +AGV ++ T + + + + + VN+ +
Sbjct: 94 VGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 146 LNMLPLVKKAQGRVINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMKAFGVHVSCI 204
+LP ++ +G VI VSS+ +V G Y SK A+ G +L ++ + V+C+
Sbjct: 154 SQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCV 213
Query: 205 EPGLFKTNLADPVKV 219
PG+ KT+ + V++
Sbjct: 214 VPGIIKTDFSKVVRI 228
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,990,694
Number of Sequences: 37866
Number of extensions: 511174
Number of successful extensions: 1538
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 1432
Number of HSP's gapped (non-prelim): 89
length of query: 319
length of database: 18,247,518
effective HSP length: 102
effective length of query: 217
effective length of database: 14,385,186
effective search space: 3121585362
effective search space used: 3121585362
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.