Search of human proteins with 40255080

Search of human proteins with 40255080

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40255080 hypothetical protein LOC158763 [Homo sapiens]
         (547 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40255080 hypothetical protein LOC158763 [Homo sapiens]            1076   0.0  
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]   284   2e-76
gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo sapi...   284   2e-76
gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo sapi...   284   2e-76
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap...    85   1e-16
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi...    85   1e-16
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           85   2e-16
gi|33188433 deleted in liver cancer 1 isoform 1 [Homo sapiens]         83   6e-16
gi|33188437 deleted in liver cancer 1 isoform 2 [Homo sapiens]         83   6e-16
gi|85815829 SH3-domain binding protein 1 [Homo sapiens]                79   1e-14
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]            78   2e-14
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]           77   3e-14
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                      77   3e-14
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                     77   3e-14
gi|215820652 StAR-related lipid transfer (START) domain containi...    76   7e-14
gi|215820650 StAR-related lipid transfer (START) domain containi...    76   7e-14
gi|31543659 StAR-related lipid transfer (START) domain containin...    76   7e-14
gi|156119615 myosin IXA [Homo sapiens]                                 75   2e-13
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]            74   4e-13
gi|39932589 Rho GTPase activating protein 18 [Homo sapiens]            73   6e-13
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa...    73   8e-13
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa...    73   8e-13
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    73   8e-13
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]             73   8e-13
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]           73   8e-13
gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]              72   1e-12
gi|188497642 ARHGAP15 [Homo sapiens]                                   72   1e-12
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]    72   1e-12
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]     72   1e-12
gi|23510413 sorting nexin 26 [Homo sapiens]                            71   2e-12

>gi|40255080 hypothetical protein LOC158763 [Homo sapiens]
          Length = 547

 Score = 1076 bits (2782), Expect = 0.0
 Identities = 547/547 (100%), Positives = 547/547 (100%)

Query: 1   MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELER 60
           MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELER
Sbjct: 1   MGGCIPFLKAARALCPRIMPPLLLLSAFIFLVSVLGGAPGHNPDRRTKMVSIHSLSELER 60

Query: 61  LKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEV 120
           LKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEV
Sbjct: 61  LKLQETAYHELVARHFLSEFKPDRALPIDRPNTLDKWFLILRGQQRAVSHKTFGISLEEV 120

Query: 121 LVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFT 180
           LVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFT
Sbjct: 121 LVNEFTRRKHLELTATMQVEEATGQAAGRRRGNVVRRVFGRIRRFFSRRRNEPTLPREFT 180

Query: 181 RRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVE 240
           RRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVE
Sbjct: 181 RRGRRGAVSVDSLAELEDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVE 240

Query: 241 ACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRD 300
           ACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRD
Sbjct: 241 ACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRD 300

Query: 301 MKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCED 360
           MKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCED
Sbjct: 301 MKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCED 360

Query: 361 SIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMID 420
           SIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMID
Sbjct: 361 SIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMID 420

Query: 421 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA 480
           NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA
Sbjct: 421 NWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPVETSA 480

Query: 481 EARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKT 540
           EARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKT
Sbjct: 481 EARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLRVPREKEAKT 540

Query: 541 GVSYFFP 547
           GVSYFFP
Sbjct: 541 GVSYFFP 547


>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
          Length = 771

 Score =  284 bits (726), Expect = 2e-76
 Identities = 183/489 (37%), Positives = 272/489 (55%), Gaps = 28/489 (5%)

Query: 46  RTKMVSIHSLSELERLKLQETAYHELVARHFLSEFKPDRALPID---RPNTLDKWFLIL- 101
           R + V I SLSELER +LQE A+++L     LS       +P D   R  +L K    L 
Sbjct: 7   RLRSVPIQSLSELERARLQEVAFYQLQQDCDLS---CQITIPKDGQKRKKSLRKKLDSLG 63

Query: 102 --RGQQRAVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAA----GRRRGNVV 155
             + + +    + FG+ L +V+ N+   +   +L    Q + +   A+    G +R N  
Sbjct: 64  KEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKE 123

Query: 156 RRVFGRIRRFFSRRRNE---PTLPREFTRRGRRGAVSVDSLAELEDG-ALLLQTLQLSKI 211
                      S   NE   P  P    R  RRGA+SVDS+ +L+D  + LL+ LQLS  
Sbjct: 124 LSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLP 183

Query: 212 SFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLRE 271
           +    ++     +K+SLNPI +Q+P++V++CCQ +EKHGL  VGIF +  S +RVRQLRE
Sbjct: 184 AEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLRE 243

Query: 272 EFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQL 331
           EFD+G+DV L++  +VHDVAALLKEF RDM D LL  +LY +F+ T  L+P++QL  LQL
Sbjct: 244 EFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQL 303

Query: 332 LVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKG 391
           L+YL+PPC+ DTL RLL+ L  +  + +D+I  DGQ V GN+MTS NLA +FG  LL K 
Sbjct: 304 LIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQ 363

Query: 392 KFGKRE-SRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDF 450
           K   +E S ++    +   A + VV+ MI+N++ LF VPP +Q +V   + ++ P+ +D+
Sbjct: 364 KSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDY 423

Query: 451 IRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGS----------SEE 500
           + RR   +  S  +   E +       +S ++  A      P D  S           +E
Sbjct: 424 LLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQE 483

Query: 501 PAVPSGTAR 509
            A P G+ +
Sbjct: 484 DAAPGGSEK 492


>gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo
           sapiens]
          Length = 765

 Score =  284 bits (726), Expect = 2e-76
 Identities = 183/489 (37%), Positives = 272/489 (55%), Gaps = 28/489 (5%)

Query: 46  RTKMVSIHSLSELERLKLQETAYHELVARHFLSEFKPDRALPID---RPNTLDKWFLIL- 101
           R + V I SLSELER +LQE A+++L     LS       +P D   R  +L K    L 
Sbjct: 210 RLRSVPIQSLSELERARLQEVAFYQLQQDCDLS---CQITIPKDGQKRKKSLRKKLDSLG 266

Query: 102 --RGQQRAVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAA----GRRRGNVV 155
             + + +    + FG+ L +V+ N+   +   +L    Q + +   A+    G +R N  
Sbjct: 267 KEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKE 326

Query: 156 RRVFGRIRRFFSRRRNE---PTLPREFTRRGRRGAVSVDSLAELEDG-ALLLQTLQLSKI 211
                      S   NE   P  P    R  RRGA+SVDS+ +L+D  + LL+ LQLS  
Sbjct: 327 LSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLP 386

Query: 212 SFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLRE 271
           +    ++     +K+SLNPI +Q+P++V++CCQ +EKHGL  VGIF +  S +RVRQLRE
Sbjct: 387 AEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLRE 446

Query: 272 EFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQL 331
           EFD+G+DV L++  +VHDVAALLKEF RDM D LL  +LY +F+ T  L+P++QL  LQL
Sbjct: 447 EFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQL 506

Query: 332 LVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKG 391
           L+YL+PPC+ DTL RLL+ L  +  + +D+I  DGQ V GN+MTS NLA +FG  LL K 
Sbjct: 507 LIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQ 566

Query: 392 KFGKRE-SRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDF 450
           K   +E S ++    +   A + VV+ MI+N++ LF VPP +Q +V   + ++ P+ +D+
Sbjct: 567 KSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDY 626

Query: 451 IRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGS----------SEE 500
           + RR   +  S  +   E +       +S ++  A      P D  S           +E
Sbjct: 627 LLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQE 686

Query: 501 PAVPSGTAR 509
            A P G+ +
Sbjct: 687 DAAPGGSEK 695


>gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo
           sapiens]
          Length = 974

 Score =  284 bits (726), Expect = 2e-76
 Identities = 183/489 (37%), Positives = 272/489 (55%), Gaps = 28/489 (5%)

Query: 46  RTKMVSIHSLSELERLKLQETAYHELVARHFLSEFKPDRALPID---RPNTLDKWFLIL- 101
           R + V I SLSELER +LQE A+++L     LS       +P D   R  +L K    L 
Sbjct: 210 RLRSVPIQSLSELERARLQEVAFYQLQQDCDLS---CQITIPKDGQKRKKSLRKKLDSLG 266

Query: 102 --RGQQRAVSHKTFGISLEEVLVNEFTRRKHLELTATMQVEEATGQAA----GRRRGNVV 155
             + + +    + FG+ L +V+ N+   +   +L    Q + +   A+    G +R N  
Sbjct: 267 KEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGNKRQNKE 326

Query: 156 RRVFGRIRRFFSRRRNE---PTLPREFTRRGRRGAVSVDSLAELEDG-ALLLQTLQLSKI 211
                      S   NE   P  P    R  RRGA+SVDS+ +L+D  + LL+ LQLS  
Sbjct: 327 LSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSITDLDDNQSRLLEALQLSLP 386

Query: 212 SFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLRE 271
           +    ++     +K+SLNPI +Q+P++V++CCQ +EKHGL  VGIF +  S +RVRQLRE
Sbjct: 387 AEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLRE 446

Query: 272 EFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQL 331
           EFD+G+DV L++  +VHDVAALLKEF RDM D LL  +LY +F+ T  L+P++QL  LQL
Sbjct: 447 EFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQLGTLQL 506

Query: 332 LVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKG 391
           L+YL+PPC+ DTL RLL+ L  +  + +D+I  DGQ V GN+MTS NLA +FG  LL K 
Sbjct: 507 LIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQ 566

Query: 392 KFGKRE-SRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDF 450
           K   +E S ++    +   A + VV+ MI+N++ LF VPP +Q +V   + ++ P+ +D+
Sbjct: 567 KSSDKEFSVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDY 626

Query: 451 IRRRNLRKIQSARIKMEEDALLSDPVETSAEARAAVLAQSKPSDEGS----------SEE 500
           + RR   +  S  +   E +       +S ++  A      P D  S           +E
Sbjct: 627 LLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNKASSGDISPYDNNSPVLSERSLLAMQE 686

Query: 501 PAVPSGTAR 509
            A P G+ +
Sbjct: 687 DAAPGGSEK 695


>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
           sapiens]
          Length = 645

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 84/305 (27%), Positives = 129/305 (42%), Gaps = 55/305 (18%)

Query: 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALL 294
           +P +VE C +FI +HG +  GIF L      V+QLR+ FD G     D + +VH VA+LL
Sbjct: 176 VPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLL 235

Query: 295 KEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLL---VYLMPPCHSDTLERLLKAL 351
           K + RD+ + ++P   Y  FLL   L   D+  A Q L   + ++P  +   L  + + L
Sbjct: 236 KLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFL 295

Query: 352 HKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVAS 411
           H+I  NC             N+M+  NLA V G                           
Sbjct: 296 HEIQLNC-----------AVNKMSVDNLATVIG--------------------------- 317

Query: 412 VNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDAL 471
           VN++R+ +++  V+ +  P IQR +              IR   +   +S  I +   A 
Sbjct: 318 VNLIRSKVEDPAVIMRGTPQIQRVMTM-----------MIRDHEVLFPKSKDIPLSPPAQ 366

Query: 472 LSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLR 531
            +DP + +  AR++V       D   S   +  S T+ S D     G  P         +
Sbjct: 367 KNDP-KKAPVARSSV-GWDATEDLRISRTDSFSSMTSDS-DTTSPTGQQPSDAFPEDSSK 423

Query: 532 VPREK 536
           VPREK
Sbjct: 424 VPREK 428


>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
           sapiens]
          Length = 638

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 84/305 (27%), Positives = 129/305 (42%), Gaps = 55/305 (18%)

Query: 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALL 294
           +P +VE C +FI +HG +  GIF L      V+QLR+ FD G     D + +VH VA+LL
Sbjct: 169 VPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLL 228

Query: 295 KEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLL---VYLMPPCHSDTLERLLKAL 351
           K + RD+ + ++P   Y  FLL   L   D+  A Q L   + ++P  +   L  + + L
Sbjct: 229 KLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFL 288

Query: 352 HKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVAS 411
           H+I  NC             N+M+  NLA V G                           
Sbjct: 289 HEIQLNC-----------AVNKMSVDNLATVIG--------------------------- 310

Query: 412 VNVVRAMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDAL 471
           VN++R+ +++  V+ +  P IQR +              IR   +   +S  I +   A 
Sbjct: 311 VNLIRSKVEDPAVIMRGTPQIQRVMTM-----------MIRDHEVLFPKSKDIPLSPPAQ 359

Query: 472 LSDPVETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDRPLLR 531
            +DP + +  AR++V       D   S   +  S T+ S D     G  P         +
Sbjct: 360 KNDP-KKAPVARSSV-GWDATEDLRISRTDSFSSMTSDS-DTTSPTGQQPSDAFPEDSSK 416

Query: 532 VPREK 536
           VPREK
Sbjct: 417 VPREK 421


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 55/198 (27%), Positives = 99/198 (50%), Gaps = 21/198 (10%)

Query: 233  KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG---LDVVLDDNQNVHD 289
            + IP +V+ CC+ +E+ GL   GI+ +  +   +  ++EE ++G   +D+  D  ++++ 
Sbjct: 1159 RYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNV 1218

Query: 290  VAALLKEFFRDMKDSLLPDDLYMSFL-LTATLKPQDQLSALQLLVYLMPPCHSDTLERLL 348
            +++LLK FFR + + L  +D Y  F+       P D+L  L+ L++ +P  H +TL+ L 
Sbjct: 1219 ISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLS 1278

Query: 349  KALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHY 408
              L  + EN E            N+M   NLA+VFG  L++       E   T + + H 
Sbjct: 1279 AHLKTVAENSEK-----------NKMEPRNLAIVFGPTLVRTS-----EDNMTHM-VTHM 1321

Query: 409  VASVNVVRAMIDNWDVLF 426
                 +V  +I + D  F
Sbjct: 1322 PDQYKIVETLIQHHDWFF 1339


>gi|33188433 deleted in liver cancer 1 isoform 1 [Homo sapiens]
          Length = 1528

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 61/229 (26%), Positives = 108/229 (47%), Gaps = 24/229 (10%)

Query: 219  LLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLD 278
            + G    +++    + +PQ ++   +++  H L  VG+F       R++ LR+  +  +D
Sbjct: 1075 VFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAID 1134

Query: 279  VVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVYLMP 337
             V  + Q+ +DVA +LK++FRD+ + L+ + L  +FL      P+DQ L A++  + L+P
Sbjct: 1135 CVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLP 1194

Query: 338  PCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE 397
              + + L+ LL  L  +T             V  N+MT TNLA+    +L       +  
Sbjct: 1195 DENREVLQTLLYFLSDVT-----------AAVKENQMTPTNLAVCLAPSLFHLNTLKREN 1243

Query: 398  S------RKTKLG------IDHYVASVNVVRAMIDNWDVLFQVPPHIQR 434
            S      RK  LG      ++  +A+   +  MI     LFQVP  + R
Sbjct: 1244 SSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSR 1292


>gi|33188437 deleted in liver cancer 1 isoform 2 [Homo sapiens]
          Length = 1091

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 61/229 (26%), Positives = 108/229 (47%), Gaps = 24/229 (10%)

Query: 219 LLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLD 278
           + G    +++    + +PQ ++   +++  H L  VG+F       R++ LR+  +  +D
Sbjct: 638 VFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAID 697

Query: 279 VVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVYLMP 337
            V  + Q+ +DVA +LK++FRD+ + L+ + L  +FL      P+DQ L A++  + L+P
Sbjct: 698 CVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLP 757

Query: 338 PCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRE 397
             + + L+ LL  L  +T             V  N+MT TNLA+    +L       +  
Sbjct: 758 DENREVLQTLLYFLSDVT-----------AAVKENQMTPTNLAVCLAPSLFHLNTLKREN 806

Query: 398 S------RKTKLG------IDHYVASVNVVRAMIDNWDVLFQVPPHIQR 434
           S      RK  LG      ++  +A+   +  MI     LFQVP  + R
Sbjct: 807 SSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSR 855


>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
          Length = 701

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 90/351 (25%), Positives = 149/351 (42%), Gaps = 33/351 (9%)

Query: 184 RRGAVSVDS-LAEL-EDGALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEA 241
           RR   S+D+ LAEL E+      +  ++   FP   R+ G      L  + ++I   +EA
Sbjct: 239 RRSLSSLDTALAELRENHGQADHSPSMTATHFP---RVYGVSLATHLQELGREIALPIEA 295

Query: 242 CCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDM 301
           C   +   G+   G+F L      +++L++        + +   + H VA  LK + R++
Sbjct: 296 CVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLREL 355

Query: 302 KDSLLPDDLYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCED 360
            + L+  DLY  ++  A+LK P  +L ALQ +   +PP +   L  L+K L ++ E  E 
Sbjct: 356 PEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQE- 414

Query: 361 SIGIDGQLVPGNRMTSTNLALVFGSALL----KKGKFGKRESRKTKLGIDHYVASVNVVR 416
                      N+MT +N+A+V G  LL    K+G   + ++          +  V VV 
Sbjct: 415 ----------VNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVS-----SIQVVGVVE 459

Query: 417 AMIDNWDVLFQVPPHIQRQVAKRVWKSSPEALDFIRRRNLRKIQSARIKMEEDALLSDPV 476
           A+I + D LF  P  I   V+     S+    D +  R L   +     +   A    P 
Sbjct: 460 ALIQSADTLF--PGDINFNVSGLF--SAVTLQDTVSDR-LASEELPSTAVPTPATTPAPA 514

Query: 477 ETSAEARAAVLAQSKPSDEGSSEEPAVPSGTARSHDDEEGAGNPPIPEQDR 527
              A A A  LA +   +   SE P  P+    +    E A   P+ +  R
Sbjct: 515 PAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAA--PVEDMAR 563


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 45/160 (28%), Positives = 88/160 (55%), Gaps = 13/160 (8%)

Query: 235 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLR--EEFDQGLDVVLDDNQNVHDVAA 292
           +P+ V+ C + +E+HGL   GI+ +  ++  +++LR     D+ LD+     +++H +  
Sbjct: 669 VPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITG 728

Query: 293 LLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALH 352
            LK FFR++ + L   + +  F+     +P+ +++A++ L+  +P  + DT++ L + L 
Sbjct: 729 ALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLR 788

Query: 353 KITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGK 392
           ++ EN E            NRMT  ++A+VFG  LLK  K
Sbjct: 789 RVIENGEK-----------NRMTYQSIAIVFGPTLLKPEK 817


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 55/198 (27%), Positives = 102/198 (51%), Gaps = 21/198 (10%)

Query: 233  KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGL-DVVLDDN--QNVHD 289
            +++P +V ACC+ +E  GL + GI+ +  +   V  L+E+ ++G  D+ L D   Q+++ 
Sbjct: 823  QRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNV 882

Query: 290  VAALLKEFFRDMKDSLLPDDLYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLL 348
            +++LLK FFR + + L  DD Y  F+    ++  ++++  L+ L+  +P  + +TL+ L+
Sbjct: 883  ISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLV 942

Query: 349  KALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHY 408
              L  I ++ E            N+M   NLALVFG  L++       E   T + + H 
Sbjct: 943  GHLKTIADHSEK-----------NKMEPRNLALVFGPTLVRTS-----EDNMTDM-VTHM 985

Query: 409  VASVNVVRAMIDNWDVLF 426
                 +V  +I + D  F
Sbjct: 986  PDRYKIVETLIQHSDWFF 1003


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 56/197 (28%), Positives = 97/197 (49%), Gaps = 21/197 (10%)

Query: 234 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG---LDVVLDDNQNVHDV 290
           Q P VV+ C + IE  GL + G++ +    + +  ++  FD+     D+  +   +++ +
Sbjct: 289 QRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINII 348

Query: 291 AALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLK 349
              LK +FRD+   ++  D Y  F+  A +   D+ L A+  ++ L+PP H +TL  L+ 
Sbjct: 349 TGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMI 408

Query: 350 ALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYV 409
            L K+T N +D           N M + NL +VFG  L++       +S  T L    Y 
Sbjct: 409 HLKKVTMNEKD-----------NFMNAENLGIVFGPTLMRP----PEDSTLTTLHDMRY- 452

Query: 410 ASVNVVRAMIDNWDVLF 426
               +V+ +I+N DVLF
Sbjct: 453 -QKLIVQILIENEDVLF 468


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 56/197 (28%), Positives = 97/197 (49%), Gaps = 21/197 (10%)

Query: 234 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG---LDVVLDDNQNVHDV 290
           Q P VV+ C + IE  GL + G++ +    + +  ++  FD+     D+  +   +++ +
Sbjct: 153 QRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINII 212

Query: 291 AALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLK 349
              LK +FRD+   ++  D Y  F+  A +   D+ L A+  ++ L+PP H +TL  L+ 
Sbjct: 213 TGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMI 272

Query: 350 ALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYV 409
            L K+T N +D           N M + NL +VFG  L++       +S  T L    Y 
Sbjct: 273 HLKKVTMNEKD-----------NFMNAENLGIVFGPTLMRP----PEDSTLTTLHDMRY- 316

Query: 410 ASVNVVRAMIDNWDVLF 426
               +V+ +I+N DVLF
Sbjct: 317 -QKLIVQILIENEDVLF 332


>gi|215820652 StAR-related lipid transfer (START) domain containing
           8 isoform b [Homo sapiens]
          Length = 1023

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 64/234 (27%), Positives = 110/234 (47%), Gaps = 25/234 (10%)

Query: 216 GQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ 275
           GQ + G    + +    + +PQ ++   +++    L  VGIF       R++ LR+  + 
Sbjct: 566 GQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNET 625

Query: 276 GLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVY 334
             D V  + Q+ +DVA LLK++FRD+ + +    L  +FL    L P+DQ L+A Q    
Sbjct: 626 SPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATL 685

Query: 335 LMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLAL-----VFGSALLK 389
           L+P  + + L+ LL  L  I    E            N+MT+ NLA+     +F   + K
Sbjct: 686 LLPDENREVLQTLLYFLSDIASAEE------------NQMTAGNLAVCLAPSIFHLNVSK 733

Query: 390 KGKFGKR-ESRKTKLG------IDHYVASVNVVRAMIDNWDVLFQVPPHIQRQV 436
           K     R +S+++ +G      +   +A+   +  MI +   LFQVP  +  Q+
Sbjct: 734 KDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQL 787


>gi|215820650 StAR-related lipid transfer (START) domain containing
           8 isoform a [Homo sapiens]
          Length = 1103

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 64/234 (27%), Positives = 110/234 (47%), Gaps = 25/234 (10%)

Query: 216 GQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ 275
           GQ + G    + +    + +PQ ++   +++    L  VGIF       R++ LR+  + 
Sbjct: 646 GQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNET 705

Query: 276 GLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVY 334
             D V  + Q+ +DVA LLK++FRD+ + +    L  +FL    L P+DQ L+A Q    
Sbjct: 706 SPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATL 765

Query: 335 LMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLAL-----VFGSALLK 389
           L+P  + + L+ LL  L  I    E            N+MT+ NLA+     +F   + K
Sbjct: 766 LLPDENREVLQTLLYFLSDIASAEE------------NQMTAGNLAVCLAPSIFHLNVSK 813

Query: 390 KGKFGKR-ESRKTKLG------IDHYVASVNVVRAMIDNWDVLFQVPPHIQRQV 436
           K     R +S+++ +G      +   +A+   +  MI +   LFQVP  +  Q+
Sbjct: 814 KDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQL 867


>gi|31543659 StAR-related lipid transfer (START) domain containing 8
           isoform b [Homo sapiens]
          Length = 1023

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 64/234 (27%), Positives = 110/234 (47%), Gaps = 25/234 (10%)

Query: 216 GQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ 275
           GQ + G    + +    + +PQ ++   +++    L  VGIF       R++ LR+  + 
Sbjct: 566 GQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNET 625

Query: 276 GLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVY 334
             D V  + Q+ +DVA LLK++FRD+ + +    L  +FL    L P+DQ L+A Q    
Sbjct: 626 SPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATL 685

Query: 335 LMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLAL-----VFGSALLK 389
           L+P  + + L+ LL  L  I    E            N+MT+ NLA+     +F   + K
Sbjct: 686 LLPDENREVLQTLLYFLSDIASAEE------------NQMTAGNLAVCLAPSIFHLNVSK 733

Query: 390 KGKFGKR-ESRKTKLG------IDHYVASVNVVRAMIDNWDVLFQVPPHIQRQV 436
           K     R +S+++ +G      +   +A+   +  MI +   LFQVP  +  Q+
Sbjct: 734 KDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVPQDMVLQL 787


>gi|156119615 myosin IXA [Homo sapiens]
          Length = 2548

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 47/158 (29%), Positives = 85/158 (53%), Gaps = 12/158 (7%)

Query: 233  KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAA 292
            + +P VVE    +IE HGL   GI+    S  ++++LR+  D   + V  D+ N+H +A+
Sbjct: 2073 RTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIAS 2132

Query: 293  LLKEFFRDMKDSLLPDDLYMSFLLTATLKP-QDQLSALQLLVYLMPPCHSDTLERLLKAL 351
            + K++ RD+ + L+  +LY  FL    L+  ++ +  +  ++  +   H +TLERL+  L
Sbjct: 2133 VFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHL 2192

Query: 352  HKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLK 389
             +I    ED+          NRM++  LA+VF   +L+
Sbjct: 2193 VRIALQ-EDT----------NRMSANALAIVFAPCILR 2219


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 58/197 (29%), Positives = 99/197 (50%), Gaps = 21/197 (10%)

Query: 228 LNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEF--DQGLDVVLDDN- 284
           L    + +P V+++C +FIE HG+   GI+ L      +++LR+EF  DQ  D+  +   
Sbjct: 27  LESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYL 85

Query: 285 QNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQD-QLSALQLLVYLMPPCHSDT 343
           Q++H V +L K +FR++ + LL  +LY  F    +  P++ QL+ +Q ++  +PP H  T
Sbjct: 86  QDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRT 145

Query: 344 LERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKL 403
           LE L++ L  I      +            M + NLALV+   LL+      +E   T  
Sbjct: 146 LEYLIRHLAHIASFSSKT-----------NMHARNLALVWAPNLLR-----SKEIEATGC 189

Query: 404 GIDHYVASVNVVRAMID 420
             D    +V V + +I+
Sbjct: 190 NGDAAFLAVRVQQVVIE 206


>gi|39932589 Rho GTPase activating protein 18 [Homo sapiens]
          Length = 663

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 63/243 (25%), Positives = 110/243 (45%), Gaps = 20/243 (8%)

Query: 200 ALLLQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTL 259
           A+ ++T        P+   L   +RK+       +IP + +     IE+ GL   G+  +
Sbjct: 311 AVKIKTKDSGLFCVPLTALLEQDQRKVP----GMRIPLIFQKLISRIEERGLETEGLLRI 366

Query: 260 EYSVQRVRQLREEFDQGLDVVLDDNQNV--HDVAALLKEFFRDMKDSLLPDDLYMSFLLT 317
             +  R++ L +E +        + ++V  HD A+LLK F R++   LL  +   +F   
Sbjct: 367 PGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAV 426

Query: 318 ATLKPQ-DQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTS 376
             L  +  QL AL LLV L+P  + DTL+ LL+ L ++ +N E            N+MT 
Sbjct: 427 QNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEK-----------NKMTV 475

Query: 377 TNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQV 436
            N+A+V    L      G + S + +  +     + N +  +I    +L+ +P  I  QV
Sbjct: 476 MNVAMVMAPNLFMCHALGLKSSEQREFVM--AAGTANTMHLLIKYQKLLWTIPKFIVNQV 533

Query: 437 AKR 439
            K+
Sbjct: 534 RKQ 536


>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
           sapiens]
          Length = 653

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 58/201 (28%), Positives = 96/201 (47%), Gaps = 20/201 (9%)

Query: 236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLK 295
           P +VE C  FI + GL   G+F L      V++L++ FD G     D N +VH VA+LLK
Sbjct: 58  PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLK 117

Query: 296 EFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLL---VYLMPPCHSDTLERLLKALH 352
            + R++ + ++P   Y  FL  A L  +++ + ++ L   V  +P  + +    LLK + 
Sbjct: 118 LYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYN----LLKYIC 173

Query: 353 KITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASV 412
           +  +  +   G+       N+M+  NLA VFG  +L+     K E   T +  +  V   
Sbjct: 174 RFLDEVQSYSGV-------NKMSVQNLATVFGPNILRP----KVEDPLTIM--EGTVVVQ 220

Query: 413 NVVRAMIDNWDVLFQVPPHIQ 433
            ++  MI   D LF     +Q
Sbjct: 221 QLMSVMISKHDCLFPKDAELQ 241


>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
           sapiens]
          Length = 655

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 58/201 (28%), Positives = 96/201 (47%), Gaps = 20/201 (9%)

Query: 236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLK 295
           P +VE C  FI + GL   G+F L      V++L++ FD G     D N +VH VA+LLK
Sbjct: 60  PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLK 119

Query: 296 EFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLL---VYLMPPCHSDTLERLLKALH 352
            + R++ + ++P   Y  FL  A L  +++ + ++ L   V  +P  + +    LLK + 
Sbjct: 120 LYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYN----LLKYIC 175

Query: 353 KITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASV 412
           +  +  +   G+       N+M+  NLA VFG  +L+     K E   T +  +  V   
Sbjct: 176 RFLDEVQSYSGV-------NKMSVQNLATVFGPNILRP----KVEDPLTIM--EGTVVVQ 222

Query: 413 NVVRAMIDNWDVLFQVPPHIQ 433
            ++  MI   D LF     +Q
Sbjct: 223 QLMSVMISKHDCLFPKDAELQ 243


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 58/201 (28%), Positives = 96/201 (47%), Gaps = 20/201 (9%)

Query: 236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLK 295
           P +VE C  FI + GL   G+F L      V++L++ FD G     D N +VH VA+LLK
Sbjct: 153 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLK 212

Query: 296 EFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLL---VYLMPPCHSDTLERLLKALH 352
            + R++ + ++P   Y  FL  A L  +++ + ++ L   V  +P  + +    LLK + 
Sbjct: 213 LYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYN----LLKYIC 268

Query: 353 KITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVASV 412
           +  +  +   G+       N+M+  NLA VFG  +L+     K E   T +  +  V   
Sbjct: 269 RFLDEVQSYSGV-------NKMSVQNLATVFGPNILRP----KVEDPLTIM--EGTVVVQ 315

Query: 413 NVVRAMIDNWDVLFQVPPHIQ 433
            ++  MI   D LF     +Q
Sbjct: 316 QLMSVMISKHDCLFPKDAELQ 336


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 50/195 (25%), Positives = 94/195 (48%), Gaps = 21/195 (10%)

Query: 236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG---LDVVLDDNQNVHDVAA 292
           P VV+ C + IE  GL++ G++ +      +  ++  FD+     D+ ++  ++++ +  
Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341

Query: 293 LLKEFFRDMKDSLLPDDLYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKAL 351
            LK +FRD+   L+  D Y  F+ +A +  P +QL  L   + L+PP H +TL  L+  L
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 401

Query: 352 HKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVAS 411
            ++T + ++           N M + NL +VFG  L++  +            ++     
Sbjct: 402 KRVTLHEKE-----------NLMNAENLGIVFGPTLMRSPEL------DAMAALNDIRYQ 444

Query: 412 VNVVRAMIDNWDVLF 426
             VV  +I N D+LF
Sbjct: 445 RLVVELLIKNEDILF 459


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 50/195 (25%), Positives = 94/195 (48%), Gaps = 21/195 (10%)

Query: 236 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG---LDVVLDDNQNVHDVAA 292
           P VV+ C + IE  GL++ G++ +      +  ++  FD+     D+ ++  ++++ +  
Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315

Query: 293 LLKEFFRDMKDSLLPDDLYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKAL 351
            LK +FRD+   L+  D Y  F+ +A +  P +QL  L   + L+PP H +TL  L+  L
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375

Query: 352 HKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYVAS 411
            ++T + ++           N M + NL +VFG  L++  +            ++     
Sbjct: 376 KRVTLHEKE-----------NLMNAENLGIVFGPTLMRSPEL------DAMAALNDIRYQ 418

Query: 412 VNVVRAMIDNWDVLF 426
             VV  +I N D+LF
Sbjct: 419 RLVVELLIKNEDILF 433


>gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]
          Length = 439

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 46/160 (28%), Positives = 80/160 (50%), Gaps = 11/160 (6%)

Query: 229 NPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVH 288
           NP  + IP V+     +++ H L+  GIF    + Q VR+++++++ GL V  D    +H
Sbjct: 253 NPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELH 312

Query: 289 DVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLL 348
             A +LK F R++ + LL  DLY   +    +    ++ A   ++  +P  +   L  L 
Sbjct: 313 LPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLT 372

Query: 349 KALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALL 388
             L +I+ + +            N+MT+TNLA+VFG  LL
Sbjct: 373 AFLVQISAHSDQ-----------NKMTNTNLAVVFGPNLL 401


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 61/229 (26%), Positives = 106/229 (46%), Gaps = 28/229 (12%)

Query: 203 LQTLQLSKISFPIGQRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYS 262
           L+TLQ   +   I  ++ GS            +P  V+ C + +EK GL   GI+ +  +
Sbjct: 265 LKTLQEKGL---IKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGN 321

Query: 263 VQRVRQLREEFDQGLDVVLDDNQ--NVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATL 320
           +  +++LR   +Q   + LDD+Q  ++H V   LK FFR++ + L P   +  F+    +
Sbjct: 322 LATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFV--EAI 379

Query: 321 KPQD---QLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTST 377
           K QD   ++ A++ LV  +PP + DT++ L   L KI                 N M++ 
Sbjct: 380 KKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASK-----------NLMSTQ 428

Query: 378 NLALVFGSALLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLF 426
           +L +VFG  LL      + E+    + I H V    +   M+  +  +F
Sbjct: 429 SLGIVFGPTLL------RAENETGNMAI-HMVYQNQIAELMLSEYSKIF 470


>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
          Length = 2087

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 55/197 (27%), Positives = 99/197 (50%), Gaps = 17/197 (8%)

Query: 234 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDN---QNVHDV 290
           ++PQV+++C  FIE++G+   GI+ L      +++LR EFD      L      Q++H V
Sbjct: 384 EVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSV 442

Query: 291 AALLKEFFRDMKDSLLPDDLYMSFL-LTATLKPQDQLSALQLLVYLMPPCHSDTLERLLK 349
            +L K +FR++ + LL   LY  F    +    +++L  +  ++  +PP H  TLE L++
Sbjct: 443 GSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMR 502

Query: 350 ALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYV 409
            L  + + C  +            M + NLA+V+   LL+  +        T   ++  +
Sbjct: 503 HLSLLADYCSIT-----------NMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRI 551

Query: 410 ASVNVVRAMIDNWDVLF 426
            SV VV  ++++ DVLF
Sbjct: 552 QSV-VVEFILNHVDVLF 567


>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
          Length = 1738

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 55/197 (27%), Positives = 99/197 (50%), Gaps = 17/197 (8%)

Query: 234 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDN---QNVHDV 290
           ++PQV+++C  FIE++G+   GI+ L      +++LR EFD      L      Q++H V
Sbjct: 35  EVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSV 93

Query: 291 AALLKEFFRDMKDSLLPDDLYMSFL-LTATLKPQDQLSALQLLVYLMPPCHSDTLERLLK 349
            +L K +FR++ + LL   LY  F    +    +++L  +  ++  +PP H  TLE L++
Sbjct: 94  GSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMR 153

Query: 350 ALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKKGKFGKRESRKTKLGIDHYV 409
            L  + + C  +            M + NLA+V+   LL+  +        T   ++  +
Sbjct: 154 HLSLLADYCSIT-----------NMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRI 202

Query: 410 ASVNVVRAMIDNWDVLF 426
            SV VV  ++++ DVLF
Sbjct: 203 QSV-VVEFILNHVDVLF 218


>gi|23510413 sorting nexin 26 [Homo sapiens]
          Length = 1126

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 29/220 (13%)

Query: 217 QRLLGSKRKMSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG 276
           QR+ G      L+   + +PQV+  C +FIE HG+   GI+ L      +++LR EFD  
Sbjct: 310 QRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSE 368

Query: 277 LDVVLDDN---QNVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLK-PQDQLSALQLL 332
               L      Q++H V++L K +FR++ + LL   LY  F    ++   +++L  +  +
Sbjct: 369 RIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDV 428

Query: 333 VYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSALLKK-- 390
           +  +PP H  TLE LL+ L ++  +  ++            M + NLA+V+   LL+   
Sbjct: 429 IQQLPPPHYRTLEYLLRHLARMARHSANT-----------SMHARNLAIVWAPNLLRSME 477

Query: 391 ----GKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLF 426
               G  G    R+ +      V SV VV  ++ + DVLF
Sbjct: 478 LESVGMGGAAAFREVR------VQSV-VVEFLLTHVDVLF 510


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,971,869
Number of Sequences: 37866
Number of extensions: 869443
Number of successful extensions: 3638
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 82
Number of HSP's successfully gapped in prelim test: 56
Number of HSP's that attempted gapping in prelim test: 3382
Number of HSP's gapped (non-prelim): 183
length of query: 547
length of database: 18,247,518
effective HSP length: 107
effective length of query: 440
effective length of database: 14,195,856
effective search space: 6246176640
effective search space used: 6246176640
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.