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Search of human proteins with 40254924
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40254924 leucine rich repeat containing 59 [Homo sapiens]
(307 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40254924 leucine rich repeat containing 59 [Homo sapiens] 608 e-174
gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo sapi... 72 5e-13
gi|61742786 leucine rich repeat and death domain containing prot... 71 1e-12
gi|61742784 leucine rich repeat and death domain containing prot... 71 1e-12
gi|61742782 leucine rich repeat and death domain containing prot... 71 1e-12
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 70 2e-12
gi|45827729 scribble isoform b [Homo sapiens] 69 4e-12
gi|45827731 scribble isoform a [Homo sapiens] 69 4e-12
gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Hom... 68 9e-12
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 68 9e-12
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 67 3e-11
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 66 3e-11
gi|238908508 leucine-rich repeat and death domain-containing pro... 66 4e-11
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 66 4e-11
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 66 4e-11
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 65 6e-11
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 65 8e-11
gi|24308207 leucine rich repeat containing 47 [Homo sapiens] 64 1e-10
gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 64 1e-10
gi|27545328 leucine rich repeat containing 2 [Homo sapiens] 64 1e-10
gi|53729363 leucine rich repeat and sterile alpha motif containi... 64 2e-10
gi|53729361 leucine rich repeat and sterile alpha motif containi... 64 2e-10
gi|53729359 leucine rich repeat and sterile alpha motif containi... 64 2e-10
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 63 3e-10
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 63 3e-10
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 63 4e-10
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 62 8e-10
gi|45439342 peptidylprolyl isomerase (cyclophilin)-like 5 isofor... 61 1e-09
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 61 1e-09
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 60 2e-09
>gi|40254924 leucine rich repeat containing 59 [Homo sapiens]
Length = 307
Score = 608 bits (1567), Expect = e-174
Identities = 307/307 (100%), Positives = 307/307 (100%)
Query: 1 MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCG 60
MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCG
Sbjct: 1 MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCG 60
Query: 61 LTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
LTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL
Sbjct: 61 LTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
Query: 121 DPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAK 180
DPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAK
Sbjct: 121 DPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAK 180
Query: 181 EAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRK 240
EAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRK
Sbjct: 181 EAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRK 240
Query: 241 HTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWV 300
HTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWV
Sbjct: 241 HTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWV 300
Query: 301 LQTDSQQ 307
LQTDSQQ
Sbjct: 301 LQTDSQQ 307
>gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo
sapiens]
Length = 557
Score = 72.4 bits (176), Expect = 5e-13
Identities = 41/86 (47%), Positives = 53/86 (61%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L +L T L LS N L+ +PSD L +LV LDLS NK++ LPA+ G +V+L+ L L N
Sbjct: 47 LWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNN 106
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
N L LP +L L+ L LK NPL
Sbjct: 107 NLLRVLPFELGKLFQLQTLGLKGNPL 132
Score = 55.5 bits (132), Expect = 6e-08
Identities = 28/71 (39%), Positives = 43/71 (60%)
Query: 50 KLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKN 109
K+ +L + LTHL L LS N L ++P+D +L NL +LDL +NK+ +LP + +
Sbjct: 39 KVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVS 98
Query: 110 LKWLDLKDNPL 120
L+ L L +N L
Sbjct: 99 LRELHLNNNLL 109
Score = 50.8 bits (120), Expect = 1e-06
Identities = 30/78 (38%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L LS + L+ +P ++A L LDLS NK+ +LP++ + L +L L+ N L+ LP
Sbjct: 56 LHLSDNSLSRIP-SDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPF 114
Query: 80 DFGRLVNLQHLDLLNNKL 97
+ G+L LQ L L N L
Sbjct: 115 ELGKLFQLQTLGLKGNPL 132
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 70.9 bits (172), Expect = 1e-12
Identities = 46/107 (42%), Positives = 66/107 (61%), Gaps = 1/107 (0%)
Query: 22 LSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADF 81
LS + L+E+P + L ALP T L ++ N+L TLP L+ L +LDLS+N L LP +
Sbjct: 155 LSHNCLSELP-EALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 213
Query: 82 GRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
G L +L L+L +N+L +LP S A L++L+ L L N L V A +A
Sbjct: 214 GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLA 260
Score = 63.9 bits (154), Expect = 2e-10
Identities = 39/86 (45%), Positives = 52/86 (60%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L AL LDLS N L TLP + GL L++L+L+ N+LQ LPA L +L+ L L +
Sbjct: 190 LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHS 249
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
N L ++P A+L L LDL+DN L
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQL 275
Score = 58.9 bits (141), Expect = 5e-09
Identities = 47/123 (38%), Positives = 62/123 (50%), Gaps = 5/123 (4%)
Query: 7 KGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK 66
KGG RD L G L +L++L L+ L LDLS N L TLP+ + L
Sbjct: 98 KGGQRRDTL-GACLRGALTNLPA----GLSGLAHLAHLDLSFNSLETLPACVLQMRGLGA 152
Query: 67 LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAK 126
L LS N L +LP G L L L + +N+L TLP + L L+ LDL N LD + +
Sbjct: 153 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 212
Query: 127 VAG 129
+ G
Sbjct: 213 IGG 215
Score = 57.8 bits (138), Expect = 1e-08
Identities = 43/110 (39%), Positives = 54/110 (49%), Gaps = 1/110 (0%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDLS + L +P L +L LS N L+ LP L L L ++ N+LQ LP
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALL-LSHNCLSELPEALGALPALTFLTVTHNRLQTLPP 188
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
G L LQ LDL N L TLP L +L L+L N L + A +AG
Sbjct: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
Score = 55.5 bits (132), Expect = 6e-08
Identities = 39/101 (38%), Positives = 56/101 (55%), Gaps = 4/101 (3%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDLS + L+ +P E+ L L+L+ N+L +LP+ GL L L L N L +PA
Sbjct: 199 LDLSQNLLDTLP-PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
D RL L LDL +N+L LP +L + ++ L+ NPL
Sbjct: 258 DLARLPLLTRLDLRDNQLRDLP---PELLDAPFVRLQGNPL 295
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 70.9 bits (172), Expect = 1e-12
Identities = 46/107 (42%), Positives = 66/107 (61%), Gaps = 1/107 (0%)
Query: 22 LSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADF 81
LS + L+E+P + L ALP T L ++ N+L TLP L+ L +LDLS+N L LP +
Sbjct: 155 LSHNCLSELP-EALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 213
Query: 82 GRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
G L +L L+L +N+L +LP S A L++L+ L L N L V A +A
Sbjct: 214 GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLA 260
Score = 63.9 bits (154), Expect = 2e-10
Identities = 39/86 (45%), Positives = 52/86 (60%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L AL LDLS N L TLP + GL L++L+L+ N+LQ LPA L +L+ L L +
Sbjct: 190 LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHS 249
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
N L ++P A+L L LDL+DN L
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQL 275
Score = 58.9 bits (141), Expect = 5e-09
Identities = 47/123 (38%), Positives = 62/123 (50%), Gaps = 5/123 (4%)
Query: 7 KGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK 66
KGG RD L G L +L++L L+ L LDLS N L TLP+ + L
Sbjct: 98 KGGQRRDTL-GACLRGALTNLPA----GLSGLAHLAHLDLSFNSLETLPACVLQMRGLGA 152
Query: 67 LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAK 126
L LS N L +LP G L L L + +N+L TLP + L L+ LDL N LD + +
Sbjct: 153 LLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE 212
Query: 127 VAG 129
+ G
Sbjct: 213 IGG 215
Score = 57.8 bits (138), Expect = 1e-08
Identities = 43/110 (39%), Positives = 54/110 (49%), Gaps = 1/110 (0%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDLS + L +P L +L LS N L+ LP L L L ++ N+LQ LP
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALL-LSHNCLSELPEALGALPALTFLTVTHNRLQTLPP 188
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
G L LQ LDL N L TLP L +L L+L N L + A +AG
Sbjct: 189 ALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
Score = 55.5 bits (132), Expect = 6e-08
Identities = 39/101 (38%), Positives = 56/101 (55%), Gaps = 4/101 (3%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDLS + L+ +P E+ L L+L+ N+L +LP+ GL L L L N L +PA
Sbjct: 199 LDLSQNLLDTLP-PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
D RL L LDL +N+L LP +L + ++ L+ NPL
Sbjct: 258 DLARLPLLTRLDLRDNQLRDLP---PELLDAPFVRLQGNPL 295
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 70.9 bits (172), Expect = 1e-12
Identities = 46/107 (42%), Positives = 66/107 (61%), Gaps = 1/107 (0%)
Query: 22 LSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADF 81
LS + L+E+P + L ALP T L ++ N+L TLP L+ L +LDLS+N L LP +
Sbjct: 9 LSHNCLSELP-EALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI 67
Query: 82 GRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
G L +L L+L +N+L +LP S A L++L+ L L N L V A +A
Sbjct: 68 GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLA 114
Score = 63.9 bits (154), Expect = 2e-10
Identities = 39/86 (45%), Positives = 52/86 (60%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L AL LDLS N L TLP + GL L++L+L+ N+LQ LPA L +L+ L L +
Sbjct: 44 LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHS 103
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
N L ++P A+L L LDL+DN L
Sbjct: 104 NLLASVPADLARLPLLTRLDLRDNQL 129
Score = 55.5 bits (132), Expect = 6e-08
Identities = 39/101 (38%), Positives = 56/101 (55%), Gaps = 4/101 (3%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDLS + L+ +P E+ L L+L+ N+L +LP+ GL L L L N L +PA
Sbjct: 53 LDLSQNLLDTLP-PEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 111
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
D RL L LDL +N+L LP +L + ++ L+ NPL
Sbjct: 112 DLARLPLLTRLDLRDNQLRDLP---PELLDAPFVRLQGNPL 149
Score = 52.0 bits (123), Expect = 7e-07
Identities = 35/84 (41%), Positives = 43/84 (51%)
Query: 46 LSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFA 105
LS N L+ LP L L L ++ N+LQ LP G L LQ LDL N L TLP
Sbjct: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 68
Query: 106 QLKNLKWLDLKDNPLDPVLAKVAG 129
L +L L+L N L + A +AG
Sbjct: 69 GLGSLLELNLASNRLQSLPASLAG 92
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 70.1 bits (170), Expect = 2e-12
Identities = 36/77 (46%), Positives = 53/77 (68%)
Query: 44 LDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVS 103
LDLS N LTT+P+ F L+ LV+L+LS N+L+ LPA+ R+ L+HLD +N L T+P
Sbjct: 179 LDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPE 238
Query: 104 FAQLKNLKWLDLKDNPL 120
A +++L+ L L+ N L
Sbjct: 239 LAGMESLELLYLRRNKL 255
Score = 68.9 bits (167), Expect = 5e-12
Identities = 45/113 (39%), Positives = 67/113 (59%), Gaps = 1/113 (0%)
Query: 13 DKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKN 72
++ D +L +S + L + +L LP T+LD+ N+LT+LPS L +L KL++S N
Sbjct: 80 EQTDLTKLIISNNKLQSL-TDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHN 138
Query: 73 KLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLA 125
KL+ LP + L NL+ L L +N+L + F QL NL+ LDL +N L V A
Sbjct: 139 KLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPA 191
Score = 63.2 bits (152), Expect = 3e-10
Identities = 41/119 (34%), Positives = 67/119 (56%), Gaps = 1/119 (0%)
Query: 11 LRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLS 70
+R+ + +L++S + L +P +E+ L L L N+LT + F L++L LDLS
Sbjct: 124 IRELENLQKLNVSHNKLKILP-EEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLS 182
Query: 71 KNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
N L +PA F L +L L+L +N+L +LP ++K LK LD N L+ + ++AG
Sbjct: 183 NNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAG 241
Score = 50.4 bits (119), Expect = 2e-06
Identities = 39/126 (30%), Positives = 56/126 (44%), Gaps = 25/126 (19%)
Query: 18 NELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
+++DLS + L+ + + EL L K T LDL N L +LP + L L ++LS N+ + L
Sbjct: 452 SDVDLSFNKLSFISL-ELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKML 510
Query: 78 PADFGRLV------------------------NLQHLDLLNNKLVTLPVSFAQLKNLKWL 113
P R+ NL LDL NN L+ +P NL+ L
Sbjct: 511 PEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTL 570
Query: 114 DLKDNP 119
L NP
Sbjct: 571 LLDGNP 576
Score = 50.1 bits (118), Expect = 3e-06
Identities = 35/108 (32%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+LDLS + L VP ++L L+LS N+L +LP++ + L LD + N L+ +P
Sbjct: 178 DLDLSNNHLTTVPAS-FSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIP 236
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAK 126
+ + +L+ L L NKL LP F LK L + +N ++ + A+
Sbjct: 237 PELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIEMLEAE 283
Score = 50.1 bits (118), Expect = 3e-06
Identities = 31/104 (29%), Positives = 53/104 (50%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
++ S + L E+P + + + +DLS NKL+ + + C L L LDL N L LP
Sbjct: 430 INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPE 489
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
+ LV LQ ++L N+ LP ++ L+ + + +N + V
Sbjct: 490 EMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSV 533
Score = 47.4 bits (111), Expect = 2e-05
Identities = 40/126 (31%), Positives = 58/126 (46%), Gaps = 24/126 (19%)
Query: 25 SDLNEVPVKELAALPKATILDLSCNKLTTLPS-DFCGL---------------------- 61
S+L E ELA + +L L NKL LP C L
Sbjct: 229 SNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHL 288
Query: 62 THLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
++ LDL NKL+ +P + L +L+ LDL NN + +LP S L +LK+L L+ NPL
Sbjct: 289 NSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLR 347
Query: 122 PVLAKV 127
+ ++
Sbjct: 348 TIRREI 353
Score = 43.5 bits (101), Expect = 2e-04
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 1/82 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL + + + + + L L +LDL NKL ++P + L L +LDLS N + LP
Sbjct: 269 ELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 328
Query: 79 ADFGRLVNLQHLDLLNNKLVTL 100
G L +L+ L L N L T+
Sbjct: 329 YSLGNL-HLKFLALEGNPLRTI 349
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 69.3 bits (168), Expect = 4e-12
Identities = 48/113 (42%), Positives = 62/113 (54%), Gaps = 2/113 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+LDL +DL +P L ALP L L N+L+ LP + L LV LD+S+N+L++LP
Sbjct: 178 QLDLGGNDLEVLP-DTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDC 131
A+ G LV L L L N L LP QLK L L + N L V + GDC
Sbjct: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV-TEAIGDC 288
Score = 65.5 bits (158), Expect = 6e-11
Identities = 42/103 (40%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S +D+ E+P + + I D S N L+ LP F L L L L+ LQ LP
Sbjct: 86 ELDVSRNDIPEIP-ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALP 144
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
D G L NL L+L N L +LP S + L L+ LDL N L+
Sbjct: 145 GDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLE 187
Score = 56.6 bits (135), Expect = 3e-08
Identities = 38/107 (35%), Positives = 55/107 (51%), Gaps = 4/107 (3%)
Query: 27 LNEVPVKELAA----LPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFG 82
LN+V ++ L L L+L N L +LP+ L L +LDL N L+ LP G
Sbjct: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
Query: 83 RLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
L NL+ L L N+L LP L+ L LD+ +N L+ + A++ G
Sbjct: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGG 241
Score = 53.9 bits (128), Expect = 2e-07
Identities = 38/98 (38%), Positives = 52/98 (53%), Gaps = 7/98 (7%)
Query: 21 DLSLSDLNEVP--VKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
D S + L+ +P +L +L + D+S L LP D L +LV L+L +N L+ LP
Sbjct: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVS---LQALPGDVGNLANLVTLELRENLLKSLP 167
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLK--WLD 114
A LV L+ LDL N L LP + L NL+ WLD
Sbjct: 168 ASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Score = 53.1 bits (126), Expect = 3e-07
Identities = 60/217 (27%), Positives = 93/217 (42%), Gaps = 9/217 (4%)
Query: 18 NELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
+EL L+ + L +P + L L K T L++ N L LP + G L L L N+L L
Sbjct: 292 SELILTENLLMALP-RSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVL 350
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLA-KVAGDCLDEKQ 136
P + L LD+ N+L +LP + L NLK L L +N P+L + D ++
Sbjct: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEK 409
Query: 137 CKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEK 196
C +L + + ++ E +A R + + EA + E A EK
Sbjct: 410 VLTC--YLLPQQPPLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEK 467
Query: 197 ---ERRRKEYDA-LKAAKREQEKKPKKEANQAPKSKS 229
+RR + + LK KR E + + P S S
Sbjct: 468 RGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGS 504
Score = 52.4 bits (124), Expect = 5e-07
Identities = 37/102 (36%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L + L+ +P EL L + LD+S N+L LP++ GL L L LS+N L++LP
Sbjct: 201 ELWLDRNQLSALP-PELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
G+L L L + N+L + + +NL L L +N L
Sbjct: 260 DGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301
Score = 50.4 bits (119), Expect = 2e-06
Identities = 34/99 (34%), Positives = 48/99 (48%), Gaps = 1/99 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L + L E+P K L L LS N++ LP + LV+LD+S+N + ++P
Sbjct: 40 ELLLDANQLRELP-KPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIP 98
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKD 117
L+ D N L LP F QL++L L L D
Sbjct: 99 ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALND 137
Score = 50.4 bits (119), Expect = 2e-06
Identities = 28/75 (37%), Positives = 39/75 (52%)
Query: 46 LSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFA 105
L N+L LP F L +L KL LS N++Q+LP + + L LD+ N + +P S
Sbjct: 43 LDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK 102
Query: 106 QLKNLKWLDLKDNPL 120
K L+ D NPL
Sbjct: 103 FCKALEIADFSGNPL 117
Score = 49.3 bits (116), Expect = 4e-06
Identities = 42/121 (34%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 9 GNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLD 68
GNLR + LD+S + L E+P EL L T L LS N L LP L L L
Sbjct: 217 GNLRRLVC---LDVSENRLEELPA-ELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILK 272
Query: 69 LSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
+ +N+L ++ G NL L L N L+ LP S +L L L++ N L+ + ++
Sbjct: 273 VDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIG 332
Query: 129 G 129
G
Sbjct: 333 G 333
Score = 48.9 bits (115), Expect = 6e-06
Identities = 40/108 (37%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 17 GNELDLSLSDLNEVPVKELAA----LPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKN 72
GN +L +L E +K L A L K LDL N L LP L +L +L L +N
Sbjct: 148 GNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRN 207
Query: 73 KLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+L LP + G L L LD+ N+L LP L L L L N L
Sbjct: 208 QLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255
Score = 47.8 bits (112), Expect = 1e-05
Identities = 36/114 (31%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 15 LDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKL 74
L+ +L LS +++ +P E+A + LD+S N + +P L D S N L
Sbjct: 59 LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPL 117
Query: 75 QQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
+LP F +L +L HL L + L LP L NL L+L++N L + A ++
Sbjct: 118 SRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171
Score = 39.7 bits (91), Expect = 0.003
Identities = 22/60 (36%), Positives = 34/60 (56%)
Query: 64 LVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
L +L L N+L++LP F RL+NL+ L L +N++ LP A L LD+ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Score = 32.0 bits (71), Expect = 0.71
Identities = 23/67 (34%), Positives = 35/67 (52%), Gaps = 1/67 (1%)
Query: 63 HLVKLDLSKNKLQQLPADFGRLV-NLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
H+ +D LQ +P + R +L+ L L N+L LP F +L NL+ L L DN +
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 122 PVLAKVA 128
+ +VA
Sbjct: 73 RLPPEVA 79
Score = 32.0 bits (71), Expect = 0.71
Identities = 28/99 (28%), Positives = 41/99 (41%), Gaps = 19/99 (19%)
Query: 157 RERQRRLEVE---REAE--------------KKREAKQRAKEAQERELRKREKAEEKERR 199
RERQ+ E+E +AE +K + ++ K Q+R RE AE
Sbjct: 1355 RERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAEA 1414
Query: 200 RKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPP 238
R D + EQE + A+ +P S+ P PPP
Sbjct: 1415 RLALDGETLGEEEQEDEQPPWASPSPTSRQS--PASPPP 1451
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 69.3 bits (168), Expect = 4e-12
Identities = 48/113 (42%), Positives = 62/113 (54%), Gaps = 2/113 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+LDL +DL +P L ALP L L N+L+ LP + L LV LD+S+N+L++LP
Sbjct: 178 QLDLGGNDLEVLP-DTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDC 131
A+ G LV L L L N L LP QLK L L + N L V + GDC
Sbjct: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEV-TEAIGDC 288
Score = 65.5 bits (158), Expect = 6e-11
Identities = 42/103 (40%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S +D+ E+P + + I D S N L+ LP F L L L L+ LQ LP
Sbjct: 86 ELDVSRNDIPEIP-ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALP 144
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
D G L NL L+L N L +LP S + L L+ LDL N L+
Sbjct: 145 GDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLE 187
Score = 56.6 bits (135), Expect = 3e-08
Identities = 38/107 (35%), Positives = 55/107 (51%), Gaps = 4/107 (3%)
Query: 27 LNEVPVKELAA----LPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFG 82
LN+V ++ L L L+L N L +LP+ L L +LDL N L+ LP G
Sbjct: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
Query: 83 RLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
L NL+ L L N+L LP L+ L LD+ +N L+ + A++ G
Sbjct: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGG 241
Score = 53.9 bits (128), Expect = 2e-07
Identities = 38/98 (38%), Positives = 52/98 (53%), Gaps = 7/98 (7%)
Query: 21 DLSLSDLNEVP--VKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
D S + L+ +P +L +L + D+S L LP D L +LV L+L +N L+ LP
Sbjct: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVS---LQALPGDVGNLANLVTLELRENLLKSLP 167
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLK--WLD 114
A LV L+ LDL N L LP + L NL+ WLD
Sbjct: 168 ASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Score = 53.1 bits (126), Expect = 3e-07
Identities = 60/217 (27%), Positives = 93/217 (42%), Gaps = 9/217 (4%)
Query: 18 NELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
+EL L+ + L +P + L L K T L++ N L LP + G L L L N+L L
Sbjct: 292 SELILTENLLMALP-RSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVL 350
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLA-KVAGDCLDEKQ 136
P + L LD+ N+L +LP + L NLK L L +N P+L + D ++
Sbjct: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEK 409
Query: 137 CKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEK 196
C +L + + ++ E +A R + + EA + E A EK
Sbjct: 410 VLTC--YLLPQQPPLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEK 467
Query: 197 ---ERRRKEYDA-LKAAKREQEKKPKKEANQAPKSKS 229
+RR + + LK KR E + + P S S
Sbjct: 468 RGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGS 504
Score = 52.4 bits (124), Expect = 5e-07
Identities = 37/102 (36%), Positives = 55/102 (53%), Gaps = 1/102 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L + L+ +P EL L + LD+S N+L LP++ GL L L LS+N L++LP
Sbjct: 201 ELWLDRNQLSALP-PELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
G+L L L + N+L + + +NL L L +N L
Sbjct: 260 DGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301
Score = 50.4 bits (119), Expect = 2e-06
Identities = 34/99 (34%), Positives = 48/99 (48%), Gaps = 1/99 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L + L E+P K L L LS N++ LP + LV+LD+S+N + ++P
Sbjct: 40 ELLLDANQLRELP-KPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIP 98
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKD 117
L+ D N L LP F QL++L L L D
Sbjct: 99 ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALND 137
Score = 50.4 bits (119), Expect = 2e-06
Identities = 28/75 (37%), Positives = 39/75 (52%)
Query: 46 LSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFA 105
L N+L LP F L +L KL LS N++Q+LP + + L LD+ N + +P S
Sbjct: 43 LDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK 102
Query: 106 QLKNLKWLDLKDNPL 120
K L+ D NPL
Sbjct: 103 FCKALEIADFSGNPL 117
Score = 49.3 bits (116), Expect = 4e-06
Identities = 42/121 (34%), Positives = 59/121 (48%), Gaps = 4/121 (3%)
Query: 9 GNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLD 68
GNLR + LD+S + L E+P EL L T L LS N L LP L L L
Sbjct: 217 GNLRRLVC---LDVSENRLEELPA-ELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILK 272
Query: 69 LSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
+ +N+L ++ G NL L L N L+ LP S +L L L++ N L+ + ++
Sbjct: 273 VDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIG 332
Query: 129 G 129
G
Sbjct: 333 G 333
Score = 48.9 bits (115), Expect = 6e-06
Identities = 40/108 (37%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 17 GNELDLSLSDLNEVPVKELAA----LPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKN 72
GN +L +L E +K L A L K LDL N L LP L +L +L L +N
Sbjct: 148 GNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRN 207
Query: 73 KLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+L LP + G L L LD+ N+L LP L L L L N L
Sbjct: 208 QLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255
Score = 47.8 bits (112), Expect = 1e-05
Identities = 36/114 (31%), Positives = 57/114 (50%), Gaps = 1/114 (0%)
Query: 15 LDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKL 74
L+ +L LS +++ +P E+A + LD+S N + +P L D S N L
Sbjct: 59 LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPL 117
Query: 75 QQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
+LP F +L +L HL L + L LP L NL L+L++N L + A ++
Sbjct: 118 SRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171
Score = 39.7 bits (91), Expect = 0.003
Identities = 22/60 (36%), Positives = 34/60 (56%)
Query: 64 LVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
L +L L N+L++LP F RL+NL+ L L +N++ LP A L LD+ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Score = 32.0 bits (71), Expect = 0.71
Identities = 23/67 (34%), Positives = 35/67 (52%), Gaps = 1/67 (1%)
Query: 63 HLVKLDLSKNKLQQLPADFGRLV-NLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
H+ +D LQ +P + R +L+ L L N+L LP F +L NL+ L L DN +
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 122 PVLAKVA 128
+ +VA
Sbjct: 73 RLPPEVA 79
Score = 32.0 bits (71), Expect = 0.71
Identities = 28/99 (28%), Positives = 41/99 (41%), Gaps = 19/99 (19%)
Query: 157 RERQRRLEVE---REAE--------------KKREAKQRAKEAQERELRKREKAEEKERR 199
RERQ+ E+E +AE +K + ++ K Q+R RE AE
Sbjct: 1355 RERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAEA 1414
Query: 200 RKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPP 238
R D + EQE + A+ +P S+ P PPP
Sbjct: 1415 RLALDGETLGEEEQEDEQPPWASPSPTSRQS--PASPPP 1451
>gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Homo
sapiens]
Length = 555
Score = 68.2 bits (165), Expect = 9e-12
Identities = 40/86 (46%), Positives = 52/86 (60%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L +L T L L+ N L+ +P D L +LV LDLS NKL+ LPA+ G +V+L+ L L N
Sbjct: 52 LWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNN 111
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
N L LP +L L+ L LK NPL
Sbjct: 112 NLLRVLPYELGRLFQLQTLGLKGNPL 137
Score = 51.2 bits (121), Expect = 1e-06
Identities = 27/71 (38%), Positives = 42/71 (59%)
Query: 50 KLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKN 109
++ +L + LTHL L L+ N L ++P D +L NL +LDL +NKL +LP + +
Sbjct: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
Query: 110 LKWLDLKDNPL 120
L+ L L +N L
Sbjct: 104 LRELLLNNNLL 114
Score = 48.9 bits (115), Expect = 6e-06
Identities = 31/78 (39%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L L+ + L+ +P ++A L LDLS NKL +LP++ + L +L L+ N L+ LP
Sbjct: 61 LHLNDNYLSRIP-PDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPY 119
Query: 80 DFGRLVNLQHLDLLNNKL 97
+ GRL LQ L L N L
Sbjct: 120 ELGRLFQLQTLGLKGNPL 137
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 68.2 bits (165), Expect = 9e-12
Identities = 43/150 (28%), Positives = 75/150 (50%), Gaps = 1/150 (0%)
Query: 11 LRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLS 70
L + L LDLS++D +P+ L +P LD+ NKL LP + +L L L
Sbjct: 172 LSNLLKLTHLDLSMNDFTTIPLAVLN-MPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQ 230
Query: 71 KNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGD 130
+N++ LP + NL L L NNKL +PV ++ NL++++ +DNPL ++ +
Sbjct: 231 RNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSE 290
Query: 131 CLDEKQCKQCANKVLQHMKAVQADQERERQ 160
DE++ ++ H ++ + + Q
Sbjct: 291 GTDEEEERELFGLQFMHTYIQESRRRADHQ 320
Score = 65.5 bits (158), Expect = 6e-11
Identities = 41/106 (38%), Positives = 63/106 (59%), Gaps = 2/106 (1%)
Query: 19 ELDLSLS-DLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
+L+L+++ D+ ++P +EL+ L K T LDLS N TT+P + L LD+ NKL+QL
Sbjct: 156 KLELAVNRDICDLP-QELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQL 214
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
P R+ NL L L N++ LP + + +KNL L L +N L +
Sbjct: 215 PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDI 260
Score = 42.4 bits (98), Expect = 5e-04
Identities = 23/68 (33%), Positives = 36/68 (52%)
Query: 51 LTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNL 110
L +P +L+ LDLS+N + ++P G L LQ L L NK+ T+P + +L
Sbjct: 95 LLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASL 154
Query: 111 KWLDLKDN 118
+ L+L N
Sbjct: 155 EKLELAVN 162
Score = 40.0 bits (92), Expect = 0.003
Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 5/122 (4%)
Query: 22 LSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADF 81
+SL+ L E +E + IL + + TLPS L L + L + L ++P
Sbjct: 47 VSLTKLREKVTREDGRV----ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFI 102
Query: 82 GRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCA 141
GR NL LDL N + +P L L+ L L N + V K +C ++ +
Sbjct: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTV-PKELSNCASLEKLELAV 161
Query: 142 NK 143
N+
Sbjct: 162 NR 163
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 66.6 bits (161), Expect = 3e-11
Identities = 41/100 (41%), Positives = 60/100 (60%), Gaps = 1/100 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S + + E P + + TI++ S N ++ LP F L +L +L L+ L+ LP
Sbjct: 96 ELDISKNGVQEFP-ENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLP 154
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDN 118
A+FGRLV L+ L+L N L TLP S +L L+ LDL +N
Sbjct: 155 ANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194
Score = 59.7 bits (143), Expect = 3e-09
Identities = 41/114 (35%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 20 LDLSLSDLNEVPVKELAA----LPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQ 75
L+L+ LN+ ++ L A L K IL+L N L TLP L L +LDL N+
Sbjct: 138 LNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFG 197
Query: 76 QLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
+LP ++ NL+ L + NN L LP S +LK L +LD+ N ++ V ++G
Sbjct: 198 ELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISG 251
Score = 59.3 bits (142), Expect = 4e-09
Identities = 49/178 (27%), Positives = 82/178 (46%), Gaps = 14/178 (7%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
E D S ++L +P + L L + N L LP + ++ + L NKL+ LP
Sbjct: 303 EFDCSCNELESLP-STIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLP 361
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCK 138
+ G++ L+ L+L +N+L LP SF +LK L L L DN L + + E + +
Sbjct: 362 EEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ-SKALIPLQTEAHPETKQR 420
Query: 139 QCANKVLQHM----KAVQADQ--------ERERQRRLEVEREAEKKREAKQRAKEAQE 184
N + + Q+D E +RQ+R+ V E E K+E + A + ++
Sbjct: 421 VLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKD 478
Score = 52.4 bits (124), Expect = 5e-07
Identities = 35/103 (33%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+L LS + L ++P + L K T L + N+LT LP+ L+ L + D S N+L+ LP
Sbjct: 257 DLLLSSNMLQQLP-DSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLP 315
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
+ G L +L+ L + N L LP KN+ + L+ N L+
Sbjct: 316 STIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE 358
Score = 48.5 bits (114), Expect = 7e-06
Identities = 31/87 (35%), Positives = 42/87 (48%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
+ L LD+S N++ T+ D G L L LS N LQQLP G L L L + +
Sbjct: 226 IGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDD 285
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPLD 121
N+L LP + L L+ D N L+
Sbjct: 286 NQLTMLPNTIGNLSLLEEFDCSCNELE 312
Score = 48.1 bits (113), Expect = 1e-05
Identities = 38/125 (30%), Positives = 59/125 (47%), Gaps = 24/125 (19%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQ-- 76
EL L + + E+P K+L L + N L+ LP+ L +L +LD+SKN +Q+
Sbjct: 50 ELYLDANQIEELP-KQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFP 108
Query: 77 ---------------------LPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDL 115
LP F +L+NL L L + L LP +F +L L+ L+L
Sbjct: 109 ENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILEL 168
Query: 116 KDNPL 120
++N L
Sbjct: 169 RENHL 173
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/101 (34%), Positives = 49/101 (48%), Gaps = 1/101 (0%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDL ++ E+P + L + L + N L LP L LV LD+SKN+++ +
Sbjct: 189 LDLGNNEFGELP-EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDM 247
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
D L+ L L +N L LP S LK L L + DN L
Sbjct: 248 DISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQL 288
Score = 43.9 bits (102), Expect = 2e-04
Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 7/131 (5%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L+L + L +P K + L + LDL N+ LP + +L +L + N LQ LP
Sbjct: 166 LELRENHLKTLP-KSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 224
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDP------VLAKVAGDCLD 133
G+L L +LD+ N++ T+ + + + L+ L L N L +L K+ +D
Sbjct: 225 SIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVD 284
Query: 134 EKQCKQCANKV 144
+ Q N +
Sbjct: 285 DNQLTMLPNTI 295
Score = 39.7 bits (91), Expect = 0.003
Identities = 25/78 (32%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 42 TILDLSCNKLTTLPSDFCGLTH-LVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTL 100
++LD S L +P + L +L L N++++LP L+ L + +N L L
Sbjct: 25 SVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNL 84
Query: 101 PVSFAQLKNLKWLDLKDN 118
P + A L NLK LD+ N
Sbjct: 85 PTTIASLVNLKELDISKN 102
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 66.2 bits (160), Expect = 3e-11
Identities = 37/109 (33%), Positives = 66/109 (60%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L++ + +N++P + + L++ N+LT+LP DF T +V+L+L+ N+L ++P
Sbjct: 360 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPE 419
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
D LV+L+ L L NN L LP L+ L+ LDL++N L+ + ++A
Sbjct: 420 DVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIA 468
Score = 65.9 bits (159), Expect = 4e-11
Identities = 39/77 (50%), Positives = 45/77 (58%)
Query: 44 LDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVS 103
LDLS + LPS LT L +L L NKLQ LPA+ G LVNL L L N L +LP S
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 104 FAQLKNLKWLDLKDNPL 120
LK L+ LDL+ N L
Sbjct: 165 LDNLKKLRMLDLRHNKL 181
Score = 65.5 bits (158), Expect = 6e-11
Identities = 41/102 (40%), Positives = 58/102 (56%), Gaps = 1/102 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL+L+ + L ++P ++++ L +L LS N L LP L L +LDL +NKL+ LP
Sbjct: 406 ELNLATNQLTKIP-EDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLP 464
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+ L +LQ L L NN+L TLP L NL L L +N L
Sbjct: 465 NEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLL 506
Score = 64.3 bits (155), Expect = 1e-10
Identities = 44/100 (44%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L LS + L ++P L L K LDL NKL +LP++ L L KL L+ N+L LP
Sbjct: 430 LILSNNLLKKLP-HGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPR 488
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNP 119
G L NL HL L N L LP L+NL+ L L DNP
Sbjct: 489 GIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
Score = 63.2 bits (152), Expect = 3e-10
Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 5/115 (4%)
Query: 10 NLRDKLDGNE----LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLV 65
+L D LD + LDL + L E+P + L T L L N++TT+ D L+ L
Sbjct: 160 SLPDSLDNLKKLRMLDLRHNKLREIP-SVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218
Query: 66 KLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
L + +NK++QLPA+ G L NL LD+ +N+L LP + LDL+ N L
Sbjct: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Score = 62.0 bits (149), Expect = 6e-10
Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 18 NELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
++L++ + L +P+ + L+L+ N+LT +P D GL L L LS N L++L
Sbjct: 382 SKLNMKDNQLTSLPL-DFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 440
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
P G L L+ LDL NKL +LP A LK+L+ L L +N L
Sbjct: 441 PHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQL 483
Score = 60.5 bits (145), Expect = 2e-09
Identities = 31/96 (32%), Positives = 56/96 (58%)
Query: 33 KELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDL 92
K++ L K ++L + NK+ LP++ L +L+ LD++ N+L+ LP + G + +LDL
Sbjct: 209 KDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDL 268
Query: 93 LNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
+N+L+ LP + L +L L L+ N L + +A
Sbjct: 269 QHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLA 304
Score = 55.5 bits (132), Expect = 6e-08
Identities = 49/155 (31%), Positives = 76/155 (49%), Gaps = 11/155 (7%)
Query: 20 LDLSLSDLNEVP--VKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
LDLS ++ +P +KEL L T L L NKL +LP++ L +L+ L LS+N L L
Sbjct: 105 LDLSKRSIHILPSSIKELTQL---TELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSL 161
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV------LAKVAGDC 131
P L L+ LDL +NKL +P +L +L L L+ N + V L+K++
Sbjct: 162 PDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 221
Query: 132 LDEKQCKQCANKVLQHMKAVQADQERERQRRLEVE 166
+ E + KQ ++ + + D + L E
Sbjct: 222 IRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKE 256
Score = 55.1 bits (131), Expect = 8e-08
Identities = 35/101 (34%), Positives = 53/101 (52%), Gaps = 4/101 (3%)
Query: 22 LSLSDLNEVPVKELAA----LPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
LS+ + E +K+L A L LD++ N+L LP + T + LDL N+L L
Sbjct: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDL 276
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDN 118
P G L +L L L N+L +P S A+ L+ L+L++N
Sbjct: 277 PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENN 317
Score = 53.5 bits (127), Expect = 2e-07
Identities = 37/113 (32%), Positives = 56/113 (49%), Gaps = 1/113 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L + L +P E+ L L LS N LT+LP L L LDL NKL+++P
Sbjct: 127 ELYLYSNKLQSLPA-EVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIP 185
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDC 131
+ RL +L L L N++ T+ L L L +++N + + A++ C
Sbjct: 186 SVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELC 238
Score = 50.4 bits (119), Expect = 2e-06
Identities = 35/100 (35%), Positives = 51/100 (51%), Gaps = 2/100 (2%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LD++ + L +P KE+ + T LDL N+L LP L+ L +L L N+L +P
Sbjct: 243 LDVAHNQLEHLP-KEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPR 301
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVS-FAQLKNLKWLDLKDN 118
+ L+ L+L NN + TLP S + L L L L N
Sbjct: 302 SLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARN 341
Score = 40.8 bits (94), Expect = 0.002
Identities = 32/116 (27%), Positives = 62/116 (53%), Gaps = 8/116 (6%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLS--CNKLTTL--PSDFCGLTHLVKLDLSKNKL 74
EL+L ++++ +P L++L K L L+ C +L + PS F + + L++ N++
Sbjct: 311 ELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQF---STIYSLNMEHNRI 367
Query: 75 QQLPAD-FGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
++P F R L L++ +N+L +LP+ F ++ L+L N L + V+G
Sbjct: 368 NKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSG 423
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 65.9 bits (159), Expect = 4e-11
Identities = 40/108 (37%), Positives = 57/108 (52%), Gaps = 1/108 (0%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L L + L +P L +L +L+L N+LTT P C L L+ LDL+ N + LP
Sbjct: 262 LSLGKNKLRHIP-DTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPK 320
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKV 127
+ L NL+ L + +NKL L V QL +K L L DN L+ + K+
Sbjct: 321 EIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368
Score = 64.3 bits (155), Expect = 1e-10
Identities = 35/101 (34%), Positives = 58/101 (57%), Gaps = 1/101 (0%)
Query: 27 LNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVN 86
++E+PV +++ + L+LS NKL FC L +L LDL KN+++++PA +++
Sbjct: 499 ISEIPV-DISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
Query: 87 LQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKV 127
L L L NK T P L+NL+ LDL +N L + + +
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDI 598
Score = 63.5 bits (153), Expect = 2e-10
Identities = 31/96 (32%), Positives = 57/96 (59%), Gaps = 1/96 (1%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDL + + ++P ++ + +L L CNK T P + C L +L LDLS+N+LQ++ +
Sbjct: 538 LDLGKNQIKKIPAS-ISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISS 596
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDL 115
D L +Q L+ +N+ + P+ QL++L+ L++
Sbjct: 597 DICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Score = 60.5 bits (145), Expect = 2e-09
Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 1/109 (0%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L+ S + + +VP+ E+ K ++LS NK+ P C L L L ++ N + ++P
Sbjct: 446 LEFSGNIITDVPI-EIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPV 504
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
D L HL+L NKL+ F L NLK+LDL N + + A ++
Sbjct: 505 DISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASIS 553
Score = 60.5 bits (145), Expect = 2e-09
Identities = 34/104 (32%), Positives = 57/104 (54%), Gaps = 2/104 (1%)
Query: 19 ELDLSLSDLNEVPVK--ELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQ 76
+L+ S + P++ +L +L + I + KLT LP + +T L +LD+S N +++
Sbjct: 606 KLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE 665
Query: 77 LPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+P + G L NL L NN++ LP S L +L+ L+L N L
Sbjct: 666 IPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709
Score = 53.5 bits (127), Expect = 2e-07
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 3/91 (3%)
Query: 33 KELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLD- 91
+EL L +LDLS N+L + SD C L + KL+ S N+ P + +L +L+ L+
Sbjct: 573 RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Query: 92 --LLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+ KL LP + + LK LD+ +N +
Sbjct: 633 SQIKGRKLTRLPGELSNMTQLKELDISNNAI 663
Score = 51.2 bits (121), Expect = 1e-06
Identities = 43/149 (28%), Positives = 71/149 (47%), Gaps = 7/149 (4%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L+L + L P K L LPK LDL+ N +++LP + L +L L + NKL L
Sbjct: 285 LNLEYNQLTTFP-KALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV 343
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQ 139
+ +L+ ++ L L +NKL + + L+ L L N L + K++ C +C
Sbjct: 344 EIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKIS--CCAMLECLS 401
Query: 140 CA-NKVLQHMKAVQADQERERQRRLEVER 167
+ NK+ + K + + R+L V R
Sbjct: 402 LSDNKLTELPKYI---HKLNNLRKLHVNR 427
Score = 49.7 bits (117), Expect = 3e-06
Identities = 35/114 (30%), Positives = 59/114 (51%), Gaps = 1/114 (0%)
Query: 7 KGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVK 66
+G + D L L L + L+ +P E+ L IL++S N ++ +P + L ++ +
Sbjct: 180 QGADSGDLLGLEILSLQENGLSSLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQ 238
Query: 67 LDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
L N ++ P+D L NL+ L L NKL +P + LK L+ L+L+ N L
Sbjct: 239 LFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQL 292
Score = 46.6 bits (109), Expect = 3e-05
Identities = 33/123 (26%), Positives = 59/123 (47%), Gaps = 5/123 (4%)
Query: 9 GNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLD 68
G L + ELD+S + + E+P + + L L N+++ LP L L +L+
Sbjct: 645 GELSNMTQLKELDISNNAIREIP-RNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLN 703
Query: 69 LSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNL----KWLDLKDNPLDPVL 124
LS N L LP+ + +L+ ++ +N L+ PV + K L ++L D + +L
Sbjct: 704 LSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKIL 763
Query: 125 AKV 127
K+
Sbjct: 764 EKI 766
Score = 46.2 bits (108), Expect = 4e-05
Identities = 34/99 (34%), Positives = 50/99 (50%), Gaps = 1/99 (1%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L++S + ++ +P KE++ L L N + PSD L +L L L KNKL+ +P
Sbjct: 216 LNVSHNHISHIP-KEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDN 118
L L+ L+L N+L T P + L L LDL N
Sbjct: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGN 313
Score = 43.9 bits (102), Expect = 2e-04
Identities = 31/87 (35%), Positives = 40/87 (45%)
Query: 34 ELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLL 93
+L L IL L NKL +P L L L+L N+L P L L LDL
Sbjct: 252 DLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLT 311
Query: 94 NNKLVTLPVSFAQLKNLKWLDLKDNPL 120
N + +LP +LKNL+ L + N L
Sbjct: 312 GNLISSLPKEIRELKNLETLLMDHNKL 338
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/134 (25%), Positives = 63/134 (47%), Gaps = 4/134 (2%)
Query: 16 DGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLP-SDFCGLTHLVKLDLSKNKL 74
D ++L L E P K++ + L L N++ T +D L L L L +N L
Sbjct: 142 DNFTVNLEAKGLQEFP-KDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGL 200
Query: 75 QQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDE 134
LP++ L NL+ L++ +N + +P +QL N++ L +N ++ + + +CL
Sbjct: 201 SSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDL--ECLGN 258
Query: 135 KQCKQCANKVLQHM 148
+ L+H+
Sbjct: 259 LEILSLGKNKLRHI 272
Score = 38.9 bits (89), Expect = 0.006
Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 2/101 (1%)
Query: 20 LDLSLSDLNEVP--VKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
L+ L D N++ E+ L K L L+ NKL + L L L KN L+ +
Sbjct: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNI 387
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDN 118
P L+ L L +NKL LP +L NL+ L + N
Sbjct: 388 PEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
Score = 38.5 bits (88), Expect = 0.008
Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 1/104 (0%)
Query: 21 DLSLSDLN-EVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
+L L+D EV ++ + IL L N L +P L L LS NKL +LP
Sbjct: 353 ELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPK 412
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
+L NL+ L + N +V + + L N+ L+ N + V
Sbjct: 413 YIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDV 456
Score = 37.4 bits (85), Expect = 0.017
Identities = 24/94 (25%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 27 LNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVN 86
L +P K ++ L LS NKLT LP L +L KL +++N + ++ L N
Sbjct: 384 LKNIPEK-ISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442
Query: 87 LQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+ L+ N + +P+ + + ++L N +
Sbjct: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKI 476
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 65.9 bits (159), Expect = 4e-11
Identities = 45/126 (35%), Positives = 69/126 (54%), Gaps = 4/126 (3%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLT--TLPSDFCGLTHLVKLDLSKNKLQQL 77
L+L ++ LN +P + +LP +LDL+ N L+ +LP +F LT L L LS N + L
Sbjct: 91 LNLGMNRLNTLP-RGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEIL 149
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG-DCLDEKQ 136
P D G+L LQ L L +N L++LP +L LK L ++ N L + ++ D +KQ
Sbjct: 150 PPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQ 209
Query: 137 CKQCAN 142
+ N
Sbjct: 210 VFKAEN 215
Score = 60.1 bits (144), Expect = 2e-09
Identities = 40/113 (35%), Positives = 60/113 (53%), Gaps = 3/113 (2%)
Query: 11 LRDKLDGNELDLSLSDL---NEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKL 67
+ + + N+ ++ +SD N + V L L T L LS NKLT +P + L +L L
Sbjct: 9 VEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVL 68
Query: 68 DLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+ N++++LP L L+HL+L N+L TLP F L L+ LDL N L
Sbjct: 69 NFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 121
Score = 54.3 bits (129), Expect = 1e-07
Identities = 36/98 (36%), Positives = 53/98 (54%), Gaps = 3/98 (3%)
Query: 25 SDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQ--LPADFG 82
+ + E+P ++++L K L+L N+L TLP F L L LDL+ N L + LP +F
Sbjct: 73 NQIEELPT-QISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFF 131
Query: 83 RLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
L L+ L L +N LP +L L+ L L+DN L
Sbjct: 132 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 169
Score = 47.4 bits (111), Expect = 2e-05
Identities = 24/61 (39%), Positives = 37/61 (60%)
Query: 61 LTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
L+H+ +L LS NKL +P + L NL+ L+ NN++ LP + L+ LK L+L N L
Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
Query: 121 D 121
+
Sbjct: 99 N 99
Score = 30.8 bits (68), Expect = 1.6
Identities = 18/66 (27%), Positives = 37/66 (56%), Gaps = 4/66 (6%)
Query: 66 KLDLSKNKLQQLPADFGRLVNLQHLDLL---NNKLVTLPVSFAQLKNLKWLDLKDNPLDP 122
++D+S + + D L L H+ L +NKL +P + A+LKNL+ L+ +N ++
Sbjct: 19 EVDMSDRGISNM-LDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEE 77
Query: 123 VLAKVA 128
+ +++
Sbjct: 78 LPTQIS 83
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 65.9 bits (159), Expect = 4e-11
Identities = 45/126 (35%), Positives = 69/126 (54%), Gaps = 4/126 (3%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLT--TLPSDFCGLTHLVKLDLSKNKLQQL 77
L+L ++ LN +P + +LP +LDL+ N L+ +LP +F LT L L LS N + L
Sbjct: 38 LNLGMNRLNTLP-RGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEIL 96
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG-DCLDEKQ 136
P D G+L LQ L L +N L++LP +L LK L ++ N L + ++ D +KQ
Sbjct: 97 PPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQ 156
Query: 137 CKQCAN 142
+ N
Sbjct: 157 VFKAEN 162
Score = 54.3 bits (129), Expect = 1e-07
Identities = 36/98 (36%), Positives = 53/98 (54%), Gaps = 3/98 (3%)
Query: 25 SDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQ--LPADFG 82
+ + E+P ++++L K L+L N+L TLP F L L LDL+ N L + LP +F
Sbjct: 20 NQIEELPT-QISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFF 78
Query: 83 RLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
L L+ L L +N LP +L L+ L L+DN L
Sbjct: 79 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
Score = 48.9 bits (115), Expect = 6e-06
Identities = 32/89 (35%), Positives = 45/89 (50%), Gaps = 2/89 (2%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
+A L +L+ N++ LP+ L L L+L N+L LP FG L L+ LDL
Sbjct: 6 IAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTY 65
Query: 95 NKLV--TLPVSFAQLKNLKWLDLKDNPLD 121
N L +LP +F L L+ L L DN +
Sbjct: 66 NNLSENSLPGNFFYLTTLRALYLSDNDFE 94
Score = 44.3 bits (103), Expect = 1e-04
Identities = 25/67 (37%), Positives = 37/67 (55%)
Query: 54 LPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWL 113
+P + L +L L+ N++++LP L L+HL+L N+L TLP F L L+ L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 114 DLKDNPL 120
DL N L
Sbjct: 62 DLTYNNL 68
Score = 32.7 bits (73), Expect = 0.41
Identities = 16/45 (35%), Positives = 26/45 (57%)
Query: 77 LPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
+P + L NL+ L+ NN++ LP + L+ LK L+L N L+
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLN 46
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 65.5 bits (158), Expect = 6e-11
Identities = 39/102 (38%), Positives = 57/102 (55%), Gaps = 1/102 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S +++ E+P + ++ + D S N LT LP F L +L L ++ LQ LP
Sbjct: 86 ELDVSRNEIPEIP-ESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLP 144
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+ G L NL L+L N L LP S QL+ L+ LDL +N +
Sbjct: 145 ENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEI 186
Score = 60.8 bits (146), Expect = 1e-09
Identities = 44/123 (35%), Positives = 65/123 (52%), Gaps = 4/123 (3%)
Query: 9 GNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLD 68
GNL++ L LD+S + L +P +E++ L T L +S N L T+P L L L
Sbjct: 217 GNLKNLLC---LDVSENRLERLP-EEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILK 272
Query: 69 LSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
+ +N+L QLP G +L L L N+L+TLP S +LK L L+ N L + ++
Sbjct: 273 VDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIG 332
Query: 129 GDC 131
G C
Sbjct: 333 GCC 335
Score = 60.1 bits (144), Expect = 2e-09
Identities = 39/109 (35%), Positives = 56/109 (51%), Gaps = 4/109 (3%)
Query: 21 DLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPAD 80
D+SL L E + L L+L N LT LP L L +LDL N++ LP
Sbjct: 137 DISLQSLPE----NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPES 192
Query: 81 FGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
G L++L+ L L N+L LP LKNL LD+ +N L+ + +++G
Sbjct: 193 IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISG 241
Score = 59.7 bits (143), Expect = 3e-09
Identities = 41/133 (30%), Positives = 70/133 (52%), Gaps = 2/133 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELDL +++ +P + + AL L L N+L+ LP + L +L+ LD+S+N+L++LP
Sbjct: 178 ELDLGNNEIYNLP-ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLP 236
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCK 138
+ L +L L + N L T+P +LK L L + N L L + G+C +
Sbjct: 237 EEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQ-LPEAVGECESLTELV 295
Query: 139 QCANKVLQHMKAV 151
N++L K++
Sbjct: 296 LTENQLLTLPKSI 308
Score = 58.5 bits (140), Expect = 7e-09
Identities = 38/106 (35%), Positives = 58/106 (54%), Gaps = 8/106 (7%)
Query: 15 LDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKL 74
LDGN+L +E+P +E+ L LD+S N+L LP + GLT L L +S+N L
Sbjct: 204 LDGNQL-------SELP-QEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLL 255
Query: 75 QQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+ +P G+L L L + N+L LP + + ++L L L +N L
Sbjct: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQL 301
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 1/99 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L + L E+P ++ L K L LS N++ LP + LV+LD+S+N++ ++P
Sbjct: 40 ELLLDANQLRELP-EQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIP 98
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKD 117
LQ D N L LP SF +L+NL L + D
Sbjct: 99 ESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVND 137
Score = 56.6 bits (135), Expect = 3e-08
Identities = 38/106 (35%), Positives = 57/106 (53%), Gaps = 2/106 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L+ + L +P K + L K + L+ NKL +LP + G L + N+L ++P
Sbjct: 293 ELVLTENQLLTLP-KSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIP 351
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVL 124
A+ + L LD+ N+L+ LP+S LK LK L L DN P+L
Sbjct: 352 AEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPLL 396
Score = 52.4 bits (124), Expect = 5e-07
Identities = 28/75 (37%), Positives = 40/75 (53%)
Query: 46 LSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFA 105
L N+L LP F L L KL LS N++Q+LP + + L LD+ N++ +P S +
Sbjct: 43 LDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIS 102
Query: 106 QLKNLKWLDLKDNPL 120
K L+ D NPL
Sbjct: 103 FCKALQVADFSGNPL 117
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/89 (35%), Positives = 45/89 (50%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L L + LDL N++ LP L HL L L N+L +LP + G L NL LD+
Sbjct: 170 LTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSE 229
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
N+L LP + L +L L + N L+ +
Sbjct: 230 NRLERLPEEISGLTSLTDLVISQNLLETI 258
Score = 51.6 bits (122), Expect = 9e-07
Identities = 36/110 (32%), Positives = 58/110 (52%), Gaps = 1/110 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+L +S + L +P + L K +IL + N+LT LP L +L L++N+L LP
Sbjct: 247 DLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLP 305
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
G+L L +L+ NKLV+LP +L ++DN L + A+V+
Sbjct: 306 KSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVS 355
Score = 47.8 bits (112), Expect = 1e-05
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 1/102 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+L LS +++ +P E+A + LD+S N++ +P L D S N L +LP
Sbjct: 63 KLGLSDNEIQRLP-PEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP 121
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
F L NL L + + L +LP + L NL L+L++N L
Sbjct: 122 ESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLL 163
Score = 44.3 bits (103), Expect = 1e-04
Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 7/99 (7%)
Query: 29 EVPVKELAALPKA-------TILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADF 81
+V L LP+A T L L+ N+L TLP L L L+ +NKL LP +
Sbjct: 272 KVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331
Query: 82 GRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
G +L + +N+L +P +Q L LD+ N L
Sbjct: 332 GGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRL 370
Score = 37.7 bits (86), Expect = 0.013
Identities = 21/60 (35%), Positives = 33/60 (55%)
Query: 64 LVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
L +L L N+L++LP F +LV L+ L L +N++ LP A L LD+ N + +
Sbjct: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97
Score = 29.6 bits (65), Expect = 3.5
Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 1/67 (1%)
Query: 63 HLVKLDLSKNKLQQLPADFGRLV-NLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLD 121
H+ +D L +P + R +L+ L L N+L LP F QL L+ L L DN +
Sbjct: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
Query: 122 PVLAKVA 128
+ ++A
Sbjct: 73 RLPPEIA 79
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 65.1 bits (157), Expect = 8e-11
Identities = 36/101 (35%), Positives = 54/101 (53%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
+DLS + + +P + L L+ NKLT LP + C L L L L+ N L++LP+
Sbjct: 43 IDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPS 102
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
FG+L L+ L L N+L LP L++L +DL N +
Sbjct: 103 TFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQI 143
Score = 53.9 bits (128), Expect = 2e-07
Identities = 38/95 (40%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 27 LNEVPVKELAALPKATILDLSCNKLTTLPSDFCG-LTHLVKLDLSKNKLQQLPADFGRLV 85
L E P +DLS NK+ +LP G T L L L+ NKL LP + L
Sbjct: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
Query: 86 NLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
L+ L L NN L LP +F QL LK L L N L
Sbjct: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQL 120
Score = 50.1 bits (118), Expect = 3e-06
Identities = 36/109 (33%), Positives = 58/109 (53%), Gaps = 2/109 (1%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L L+ + L +P E+ L K L L+ N L LPS F L+ L L LS N+L LP
Sbjct: 67 LSLNNNKLTVLP-DEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPP 125
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVA 128
L +L +DL N++ ++P S +L+ ++ L+L N + + K++
Sbjct: 126 QLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKIS 173
Score = 49.7 bits (117), Expect = 3e-06
Identities = 33/83 (39%), Positives = 43/83 (51%), Gaps = 2/83 (2%)
Query: 40 KATILDLSCNKLTTLPSDFCGLT-HLVKLDLSKNKLQQL-PADFGRLVNLQHLDLLNNKL 97
K + L LT P+D LT +L +DLS NK++ L P G+ L+ L L NNKL
Sbjct: 15 KTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKL 74
Query: 98 VTLPVSFAQLKNLKWLDLKDNPL 120
LP LK L+ L L +N L
Sbjct: 75 TVLPDEICNLKKLETLSLNNNHL 97
>gi|24308207 leucine rich repeat containing 47 [Homo sapiens]
Length = 583
Score = 64.3 bits (155), Expect = 1e-10
Identities = 60/200 (30%), Positives = 84/200 (42%), Gaps = 37/200 (18%)
Query: 34 ELAALPKATILDLSCNKLTTLP-------SDFCGLTHLVKLDLSKNKLQQLPADFGRLV- 85
EL LP +LDLS N L LP ++ GL L L+LS N+L++LPAD R
Sbjct: 94 ELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAP 153
Query: 86 NLQHLDLLNNKLVTLPV--------------------------SFAQLKNLKWLDLKDNP 119
LQ L+L N L + P A L +LK LDL +N
Sbjct: 154 RLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQ 213
Query: 120 LDPVLAKVAGDCLDEKQCKQCANKVLQHM--KAVQADQERERQRRLEVEREAEKKREAKQ 177
L + A++A DC K+ NK+ K V Q R L V K + +
Sbjct: 214 LSEIPAELA-DCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILEYLRVGGRGGGKGKGRA 272
Query: 178 RAKEAQERELRKREKAEEKE 197
E +E ++RE+ + +E
Sbjct: 273 EGSEKEESRRKRRERKQRRE 292
Score = 57.4 bits (137), Expect = 2e-08
Identities = 48/173 (27%), Positives = 78/173 (45%), Gaps = 14/173 (8%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFC---GLTHLVKLDLSKNKLQQ 76
L+LS + L E+P P+ L+L+ N L + P++ L L +L + N L++
Sbjct: 134 LNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRE 193
Query: 77 LPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL-DPVLAKVAGDCLDEK 135
L D L +L+ LDL NN+L +P A LK ++ + N L D L K+ C
Sbjct: 194 LSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRLEKMVSGCQ--- 250
Query: 136 QCKQCANKVLQHMK--AVQADQERERQRRLEVEREAEKKREAKQRAKEAQERE 186
+L++++ + + R E E K+RE KQR + E
Sbjct: 251 -----TRSILEYLRVGGRGGGKGKGRAEGSEKEESRRKRRERKQRREGGDGEE 298
>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 64.3 bits (155), Expect = 1e-10
Identities = 50/158 (31%), Positives = 76/158 (48%), Gaps = 28/158 (17%)
Query: 26 DLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLV 85
+L E+P EL+ L + T +D+S NK +++P +++L LD+S N L LP D RL
Sbjct: 202 ELMELPF-ELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLE 260
Query: 86 NLQHLDLLNNKLVTLPVSFAQLKN------------------------LKWLDLKDNPLD 121
LQ L NKL LP S LK LK++ L DNP+D
Sbjct: 261 ELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPID 320
Query: 122 PVLAKVAGDCLDEKQCKQCANKVLQHMKAVQAD-QERE 158
+ + ++ ++ +Q +K + MKA D +ERE
Sbjct: 321 NAQCEDGNEIMESERDRQHFDK--EVMKAYIEDLKERE 356
Score = 43.1 bits (100), Expect = 3e-04
Identities = 36/121 (29%), Positives = 58/121 (47%), Gaps = 6/121 (4%)
Query: 11 LRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLS 70
L DK++ N +L+ + +P K+ A + +LS T LP THL + +S
Sbjct: 75 LLDKIERN----TLTRQSSLP-KDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYIS 129
Query: 71 KNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGD 130
+Q +P ++ LDL N++ LP LKNLK L++ N L + ++ GD
Sbjct: 130 NTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPEL-GD 188
Query: 131 C 131
C
Sbjct: 189 C 189
>gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 64.3 bits (155), Expect = 1e-10
Identities = 50/158 (31%), Positives = 76/158 (48%), Gaps = 28/158 (17%)
Query: 26 DLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLV 85
+L E+P EL+ L + T +D+S NK +++P +++L LD+S N L LP D RL
Sbjct: 202 ELMELPF-ELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLE 260
Query: 86 NLQHLDLLNNKLVTLPVSFAQLKN------------------------LKWLDLKDNPLD 121
LQ L NKL LP S LK LK++ L DNP+D
Sbjct: 261 ELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMDNPID 320
Query: 122 PVLAKVAGDCLDEKQCKQCANKVLQHMKAVQAD-QERE 158
+ + ++ ++ +Q +K + MKA D +ERE
Sbjct: 321 NAQCEDGNEIMESERDRQHFDK--EVMKAYIEDLKERE 356
Score = 43.1 bits (100), Expect = 3e-04
Identities = 36/121 (29%), Positives = 58/121 (47%), Gaps = 6/121 (4%)
Query: 11 LRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLS 70
L DK++ N +L+ + +P K+ A + +LS T LP THL + +S
Sbjct: 75 LLDKIERN----TLTRQSSLP-KDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYIS 129
Query: 71 KNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGD 130
+Q +P ++ LDL N++ LP LKNLK L++ N L + ++ GD
Sbjct: 130 NTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLKSIPPEL-GD 188
Query: 131 C 131
C
Sbjct: 189 C 189
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 63.9 bits (154), Expect = 2e-10
Identities = 34/86 (39%), Positives = 52/86 (60%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L +L +LDL N+LT LP D LT L L++ +N+L QLP G L LQ L++ +
Sbjct: 77 LLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKD 136
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
NKL LP + +L++L+ L++ N +
Sbjct: 137 NKLKELPDTVGELRSLRTLNISGNEI 162
Score = 57.8 bits (138), Expect = 1e-08
Identities = 59/247 (23%), Positives = 110/247 (44%), Gaps = 25/247 (10%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDL + L +P +L L +L++ N+L LP LT L L++ NKL++LP
Sbjct: 86 LDLHDNQLTALP-DDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPD 144
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG---DCLDEKQ 136
G L +L+ L++ N++ LP A ++ L+ L L + + +V G + +
Sbjct: 145 TVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFL 204
Query: 137 CKQCANKVL---QHMKAV-----------QADQERERQRRLEVE-----REAEKKREAKQ 177
CK+ + Q++ + D +R R E+E + EK++E K
Sbjct: 205 CKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKM 264
Query: 178 RAKEAQER--ELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRK 235
K ER EL +RE + ++ + D + +E++ + ++ ++ + + R R
Sbjct: 265 LEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRL 324
Query: 236 PPPRKHT 242
K T
Sbjct: 325 QEQLKQT 331
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 63.9 bits (154), Expect = 2e-10
Identities = 34/86 (39%), Positives = 52/86 (60%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L +L +LDL N+LT LP D LT L L++ +N+L QLP G L LQ L++ +
Sbjct: 77 LLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKD 136
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
NKL LP + +L++L+ L++ N +
Sbjct: 137 NKLKELPDTVGELRSLRTLNISGNEI 162
Score = 57.8 bits (138), Expect = 1e-08
Identities = 59/247 (23%), Positives = 110/247 (44%), Gaps = 25/247 (10%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDL + L +P +L L +L++ N+L LP LT L L++ NKL++LP
Sbjct: 86 LDLHDNQLTALP-DDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPD 144
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG---DCLDEKQ 136
G L +L+ L++ N++ LP A ++ L+ L L + + +V G + +
Sbjct: 145 TVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFL 204
Query: 137 CKQCANKVL---QHMKAV-----------QADQERERQRRLEVE-----REAEKKREAKQ 177
CK+ + Q++ + D +R R E+E + EK++E K
Sbjct: 205 CKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKM 264
Query: 178 RAKEAQER--ELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRK 235
K ER EL +RE + ++ + D + +E++ + ++ ++ + + R R
Sbjct: 265 LEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRL 324
Query: 236 PPPRKHT 242
K T
Sbjct: 325 QEQLKQT 331
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 63.9 bits (154), Expect = 2e-10
Identities = 34/86 (39%), Positives = 52/86 (60%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
L +L +LDL N+LT LP D LT L L++ +N+L QLP G L LQ L++ +
Sbjct: 77 LLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKD 136
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
NKL LP + +L++L+ L++ N +
Sbjct: 137 NKLKELPDTVGELRSLRTLNISGNEI 162
Score = 57.8 bits (138), Expect = 1e-08
Identities = 59/247 (23%), Positives = 110/247 (44%), Gaps = 25/247 (10%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDL + L +P +L L +L++ N+L LP LT L L++ NKL++LP
Sbjct: 86 LDLHDNQLTALP-DDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPD 144
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG---DCLDEKQ 136
G L +L+ L++ N++ LP A ++ L+ L L + + +V G + +
Sbjct: 145 TVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFL 204
Query: 137 CKQCANKVL---QHMKAV-----------QADQERERQRRLEVE-----REAEKKREAKQ 177
CK+ + Q++ + D +R R E+E + EK++E K
Sbjct: 205 CKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKM 264
Query: 178 RAKEAQER--ELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRK 235
K ER EL +RE + ++ + D + +E++ + ++ ++ + + R R
Sbjct: 265 LEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRL 324
Query: 236 PPPRKHT 242
K T
Sbjct: 325 QEQLKQT 331
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 63.2 bits (152), Expect = 3e-10
Identities = 40/105 (38%), Positives = 59/105 (56%), Gaps = 1/105 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S + + E P + + TI++ S N ++ LP F L +L +L L+ L+ LP
Sbjct: 96 ELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
A+FGRL LQ L+L N+L LP + +L L+ LDL N V
Sbjct: 155 ANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEV 199
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/107 (36%), Positives = 53/107 (49%), Gaps = 8/107 (7%)
Query: 14 KLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNK 73
K+D N+L + L D + L LD S N++ LPS LT+L N
Sbjct: 282 KIDENQL-MYLPD-------SIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNY 333
Query: 74 LQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
LQQLP + G N+ L L +NKL TLP ++ LK ++L DN L
Sbjct: 334 LQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Score = 53.5 bits (127), Expect = 2e-07
Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 2/112 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+L LS + L ++P + + +L T L + N+L LP GL + +LD S N+++ LP
Sbjct: 257 DLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALP 315
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGD 130
+ G+L NL+ +N L LP KN+ L L N L+ L + GD
Sbjct: 316 SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLE-TLPEEMGD 366
Score = 53.1 bits (126), Expect = 3e-07
Identities = 36/99 (36%), Positives = 51/99 (51%), Gaps = 1/99 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L + + E+P K+L L L N LTTLP+ L +L +LD+SKN +Q+ P
Sbjct: 50 ELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFP 108
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKD 117
+ L ++ N + LP F+QL NL L L D
Sbjct: 109 ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLND 147
Score = 53.1 bits (126), Expect = 3e-07
Identities = 51/190 (26%), Positives = 84/190 (44%), Gaps = 14/190 (7%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD S +++ +P + L N L LP + ++ L L NKL+ LP
Sbjct: 303 ELDCSFNEVEALP-SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCK 138
+ G + L+ ++L +N+L LP SF +L+ L + L DN P++ L ++
Sbjct: 362 EEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP------LQKETDS 415
Query: 139 QCANKVLQHMKAVQADQERERQRRLEVEREAEK----KREAKQRAKEAQERELRKREK-A 193
+ VL + Q Q R + E+ + + KQRA+ A E + K E+ A
Sbjct: 416 ETQKMVLTNYMFPQ--QPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREA 473
Query: 194 EEKERRRKEY 203
+E K Y
Sbjct: 474 PPREGNLKRY 483
Score = 52.8 bits (125), Expect = 4e-07
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 5/103 (4%)
Query: 20 LDLSLSDLNEVP--VKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
LDL ++ EVP +++L+ L + + N+LT +P L L LD+SKN ++ +
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFW---MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMV 245
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
NLQ L L +N L LP + LKN+ L + +N L
Sbjct: 246 EEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQL 288
Score = 49.3 bits (116), Expect = 4e-06
Identities = 35/108 (32%), Positives = 55/108 (50%), Gaps = 4/108 (3%)
Query: 20 LDLSLSDLNEVPVKELAA----LPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQ 75
L+L+ LN+ ++ L A L K IL+L N+L LP LT L +LDL N+
Sbjct: 138 LNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
Query: 76 QLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
++P +L L+ + N+L +P LK L +LD+ N ++ V
Sbjct: 198 EVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMV 245
Score = 48.5 bits (114), Expect = 7e-06
Identities = 34/102 (33%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 20 LDLSLSDLNEVPVKELAALPKATI-LDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
LD S L +VP KE+ K L L N++ LP L KL L N L LP
Sbjct: 27 LDYSHCSLEQVP-KEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLP 85
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
A L+NL+ LD+ N + P + K L ++ NP+
Sbjct: 86 ASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPI 127
Score = 47.0 bits (110), Expect = 2e-05
Identities = 29/93 (31%), Positives = 48/93 (51%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
+ +L + T LD+S N + + +L L LS N LQQLP G L N+ L +
Sbjct: 226 IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE 285
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKV 127
N+L+ LP S L +++ LD N ++ + + +
Sbjct: 286 NQLMYLPDSIGGLISVEELDCSFNEVEALPSSI 318
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 63.2 bits (152), Expect = 3e-10
Identities = 40/105 (38%), Positives = 59/105 (56%), Gaps = 1/105 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S + + E P + + TI++ S N ++ LP F L +L +L L+ L+ LP
Sbjct: 96 ELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
A+FGRL LQ L+L N+L LP + +L L+ LDL N V
Sbjct: 155 ANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEV 199
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/107 (36%), Positives = 53/107 (49%), Gaps = 8/107 (7%)
Query: 14 KLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNK 73
K+D N+L + L D + L LD S N++ LPS LT+L N
Sbjct: 282 KIDENQL-MYLPD-------SIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNY 333
Query: 74 LQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
LQQLP + G N+ L L +NKL TLP ++ LK ++L DN L
Sbjct: 334 LQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Score = 53.5 bits (127), Expect = 2e-07
Identities = 37/112 (33%), Positives = 58/112 (51%), Gaps = 2/112 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+L LS + L ++P + + +L T L + N+L LP GL + +LD S N+++ LP
Sbjct: 257 DLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALP 315
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGD 130
+ G+L NL+ +N L LP KN+ L L N L+ L + GD
Sbjct: 316 SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLE-TLPEEMGD 366
Score = 53.1 bits (126), Expect = 3e-07
Identities = 36/99 (36%), Positives = 51/99 (51%), Gaps = 1/99 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL L + + E+P K+L L L N LTTLP+ L +L +LD+SKN +Q+ P
Sbjct: 50 ELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFP 108
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKD 117
+ L ++ N + LP F+QL NL L L D
Sbjct: 109 ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLND 147
Score = 53.1 bits (126), Expect = 3e-07
Identities = 51/190 (26%), Positives = 84/190 (44%), Gaps = 14/190 (7%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD S +++ +P + L N L LP + ++ L L NKL+ LP
Sbjct: 303 ELDCSFNEVEALP-SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCK 138
+ G + L+ ++L +N+L LP SF +L+ L + L DN P++ L ++
Sbjct: 362 EEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP------LQKETDS 415
Query: 139 QCANKVLQHMKAVQADQERERQRRLEVEREAEK----KREAKQRAKEAQERELRKREK-A 193
+ VL + Q Q R + E+ + + KQRA+ A E + K E+ A
Sbjct: 416 ETQKMVLTNYMFPQ--QPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREA 473
Query: 194 EEKERRRKEY 203
+E K Y
Sbjct: 474 PPREGNLKRY 483
Score = 52.8 bits (125), Expect = 4e-07
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 5/103 (4%)
Query: 20 LDLSLSDLNEVP--VKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
LDL ++ EVP +++L+ L + + N+LT +P L L LD+SKN ++ +
Sbjct: 189 LDLGSNEFTEVPEVLEQLSGLKEFW---MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMV 245
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
NLQ L L +N L LP + LKN+ L + +N L
Sbjct: 246 EEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQL 288
Score = 49.3 bits (116), Expect = 4e-06
Identities = 35/108 (32%), Positives = 55/108 (50%), Gaps = 4/108 (3%)
Query: 20 LDLSLSDLNEVPVKELAA----LPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQ 75
L+L+ LN+ ++ L A L K IL+L N+L LP LT L +LDL N+
Sbjct: 138 LNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
Query: 76 QLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
++P +L L+ + N+L +P LK L +LD+ N ++ V
Sbjct: 198 EVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMV 245
Score = 48.5 bits (114), Expect = 7e-06
Identities = 34/102 (33%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 20 LDLSLSDLNEVPVKELAALPKATI-LDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
LD S L +VP KE+ K L L N++ LP L KL L N L LP
Sbjct: 27 LDYSHCSLEQVP-KEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLP 85
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
A L+NL+ LD+ N + P + K L ++ NP+
Sbjct: 86 ASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPI 127
Score = 47.0 bits (110), Expect = 2e-05
Identities = 29/93 (31%), Positives = 48/93 (51%)
Query: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
+ +L + T LD+S N + + +L L LS N LQQLP G L N+ L +
Sbjct: 226 IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE 285
Query: 95 NKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKV 127
N+L+ LP S L +++ LD N ++ + + +
Sbjct: 286 NQLMYLPDSIGGLISVEELDCSFNEVEALPSSI 318
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 62.8 bits (151), Expect = 4e-10
Identities = 30/93 (32%), Positives = 59/93 (63%), Gaps = 1/93 (1%)
Query: 152 QADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKR 211
Q + ER+++RR +R+ E+++E K+ + ++++ +KRE+ +E+ER+RKE + + +R
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 212 EQE-KKPKKEANQAPKSKSGSRPRKPPPRKHTR 243
E+E +K KKE + + + G R RK + R
Sbjct: 91 EKERRKRKKEKKKRERKQRGRRERKKKKERKER 123
Score = 60.1 bits (144), Expect = 2e-09
Identities = 36/111 (32%), Positives = 63/111 (56%), Gaps = 5/111 (4%)
Query: 134 EKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKA 193
EKQ K+ K + K ++++R+R+ RE +KK+E K+R +E ++R RKR+K
Sbjct: 83 EKQRKERREKERRKRKK----EKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKR 138
Query: 194 EEKERRRKEYDALKAAKREQE-KKPKKEANQAPKSKSGSRPRKPPPRKHTR 243
+K+RR++ + KRE++ KK KKE + + ++ +K RK R
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERR 189
Score = 56.2 bits (134), Expect = 4e-08
Identities = 32/114 (28%), Positives = 63/114 (55%), Gaps = 4/114 (3%)
Query: 134 EKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQEREL----RK 189
EK+ ++ + + K + +ERER+ + ER+ +K+R+ K+R + +E+E RK
Sbjct: 100 EKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERK 159
Query: 190 REKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTR 243
R+K +++ER +K K K+E+E+K ++E + K + + + RK R
Sbjct: 160 RKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDR 213
Score = 54.7 bits (130), Expect = 1e-07
Identities = 27/86 (31%), Positives = 53/86 (61%), Gaps = 1/86 (1%)
Query: 155 QERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQE 214
+ERE+QR+ E+E K+++ K++ +E ++R R+R+K +E++ R +E + KR++
Sbjct: 80 KEREKQRKERREKERRKRKKEKKK-RERKQRGRRERKKKKERKERERENKQRRERKRKKR 138
Query: 215 KKPKKEANQAPKSKSGSRPRKPPPRK 240
+K K+ + + + G R RK RK
Sbjct: 139 RKKKRRKERKREKERGKRERKRKKRK 164
Score = 54.3 bits (129), Expect = 1e-07
Identities = 30/89 (33%), Positives = 55/89 (61%), Gaps = 2/89 (2%)
Query: 155 QERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQE 214
+ERE++R+ E ++ +KKR+ ++R KE +ER+ ++REK + KERR KE K K+++E
Sbjct: 48 REREKERKRERGKKEKKKRKKRERGKE-RERKRKEREK-QRKERREKERRKRKKEKKKRE 105
Query: 215 KKPKKEANQAPKSKSGSRPRKPPPRKHTR 243
+K + + K + R R+ R+ +
Sbjct: 106 RKQRGRRERKKKKERKERERENKQRRERK 134
Score = 52.4 bits (124), Expect = 5e-07
Identities = 27/106 (25%), Positives = 59/106 (55%), Gaps = 2/106 (1%)
Query: 138 KQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKE 197
K+ K + K + +E+ER++R + +++ E+K+ ++ K+ +ER+ R+RE + +E
Sbjct: 73 KERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE 132
Query: 198 RRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTR 243
R+RK+ K +R++ K+ K+ + K K + + R+ R
Sbjct: 133 RKRKK--RRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNR 176
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/91 (32%), Positives = 56/91 (61%), Gaps = 4/91 (4%)
Query: 154 DQERERQR-RLEVEREAEKKRE-AKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKR 211
++E+ER+R R + E++ KKRE K+R ++ +ERE +++E+ E++ R+RK+ + K+
Sbjct: 49 EREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQ 108
Query: 212 --EQEKKPKKEANQAPKSKSGSRPRKPPPRK 240
+E+K KKE + + R RK R+
Sbjct: 109 RGRRERKKKKERKERERENKQRRERKRKKRR 139
Score = 50.8 bits (120), Expect = 1e-06
Identities = 29/96 (30%), Positives = 60/96 (62%), Gaps = 3/96 (3%)
Query: 149 KAVQADQERERQRRLEVEREAEKKR-EAKQRAKEAQERELRKREKAEEKERRRKEYDALK 207
K + +E++++++ E +E E+KR E +++ KE +E+E RKR+K E+K+R RK+ +
Sbjct: 55 KRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKK-EKKKRERKQ-RGRR 112
Query: 208 AAKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTR 243
K+++E+K ++ N+ + + + RK RK +
Sbjct: 113 ERKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Score = 44.3 bits (103), Expect = 1e-04
Identities = 23/82 (28%), Positives = 52/82 (63%), Gaps = 8/82 (9%)
Query: 155 QERERQRRLEVEREAEK-KREAKQRAKEAQERELRK-------REKAEEKERRRKEYDAL 206
+ R+++RR E +RE E+ KRE K++ ++ +ERE ++ +++ E KERR ++ +
Sbjct: 137 KRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERK 196
Query: 207 KAAKREQEKKPKKEANQAPKSK 228
K ++++E+K ++ ++ S+
Sbjct: 197 KERRKKKERKKDRKTDRQTDSQ 218
Score = 40.8 bits (94), Expect = 0.002
Identities = 22/71 (30%), Positives = 42/71 (59%), Gaps = 4/71 (5%)
Query: 155 QERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEE----KERRRKEYDALKAAK 210
+ER+R++R + ERE +++R K+R KE + +E R+R+K + K++ RK+
Sbjct: 156 RERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQT 215
Query: 211 REQEKKPKKEA 221
Q +P +E+
Sbjct: 216 DSQVFRPLRES 226
Score = 38.5 bits (88), Expect = 0.008
Identities = 19/57 (33%), Positives = 34/57 (59%), Gaps = 2/57 (3%)
Query: 179 AKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRK 235
+K +RE ++++ E+E+R++E + K KRE+ KK KK+ + + K R RK
Sbjct: 26 SKPCTQRESERKKERREREKRKRERE--KERKRERGKKEKKKRKKRERGKERERKRK 80
Score = 35.4 bits (80), Expect = 0.064
Identities = 13/69 (18%), Positives = 42/69 (60%)
Query: 133 DEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREK 192
+ K+ K+ + + K + ++E++R+R + ++ +++E ++R KE ++ +K+E+
Sbjct: 146 ERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKER 205
Query: 193 AEEKERRRK 201
++++ R+
Sbjct: 206 KKDRKTDRQ 214
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 61.6 bits (148), Expect = 8e-10
Identities = 43/111 (38%), Positives = 60/111 (54%), Gaps = 1/111 (0%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S + L +P ++++AL IL LS +L TLP+ FC L L L L N LQ LP
Sbjct: 208 ELDVSSNRLRGLP-EDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALP 266
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAG 129
A F L L+ L+L +N P + L L+ L L N L V + ++G
Sbjct: 267 AQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG 317
Score = 61.2 bits (147), Expect = 1e-09
Identities = 38/102 (37%), Positives = 57/102 (55%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S + L + + ++AL + L+LS N+L LP+ L HL +LD+S N+L LP
Sbjct: 115 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP 174
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
L L+ LD+ +N+L P QL L+ LD+ N L
Sbjct: 175 DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRL 216
Score = 61.2 bits (147), Expect = 1e-09
Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 3/132 (2%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
ELD+S + L +P L+ L + LD+ N+LT P L L +LD+S N+L+ LP
Sbjct: 162 ELDVSFNRLAHLP-DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLP 220
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCK 138
D L L+ L L +L TLP F +L +L+ L L +N L + A+ + CL +
Sbjct: 221 EDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFS--CLQRLKML 278
Query: 139 QCANKVLQHMKA 150
++ + + A
Sbjct: 279 NLSSNLFEEFPA 290
Score = 57.8 bits (138), Expect = 1e-08
Identities = 40/103 (38%), Positives = 55/103 (53%), Gaps = 5/103 (4%)
Query: 20 LDLSLSDLNEVPVKELAALPKATI--LDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQL 77
L+LS + E P A LP A + L LS N+LT++PS GL L+ L L N+++ L
Sbjct: 278 LNLSSNLFEEFPA---ALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYL 334
Query: 78 PADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
P L L+ L L N++ LP F QL + +KDNPL
Sbjct: 335 PDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPL 377
Score = 53.1 bits (126), Expect = 3e-07
Identities = 36/97 (37%), Positives = 53/97 (54%), Gaps = 3/97 (3%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
+L+LS + L +P +L AL LD+S N+L LP L+ L LD+ N+L P
Sbjct: 139 KLNLSHNQLPALPA-QLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP 197
Query: 79 ADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLK--WL 113
+LV L+ LD+ +N+L LP + L+ LK WL
Sbjct: 198 RQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL 234
Score = 48.9 bits (115), Expect = 6e-06
Identities = 47/156 (30%), Positives = 72/156 (46%), Gaps = 8/156 (5%)
Query: 16 DGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTH-LVKLDLSKNKL 74
D L+L + L EVP +AL +L L N+ LP L H L +LD+S N+L
Sbjct: 64 DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRL 123
Query: 75 QQLPAD-FGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV------LAKV 127
L A+ L L+ L+L +N+L LP L +L+ LD+ N L + L+++
Sbjct: 124 TALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRL 183
Query: 128 AGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRL 163
+D Q ++LQ + + D R R L
Sbjct: 184 RTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGL 219
Score = 42.0 bits (97), Expect = 7e-04
Identities = 32/101 (31%), Positives = 51/101 (50%), Gaps = 1/101 (0%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
L L + L +P + + L + +L+LS N P+ L L +L LS+N+L +P+
Sbjct: 255 LMLDNNGLQALPA-QFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPS 313
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
L L L L NN++ LP S +L L+ L L+ N +
Sbjct: 314 LISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQI 354
Score = 37.0 bits (84), Expect = 0.022
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLP 78
EL LS + L VP ++ L + L L N++ LP LT L +L L N++ LP
Sbjct: 300 ELYLSRNQLTSVP-SLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLP 358
Query: 79 ADFGRLVNLQHLDLLNNKLVTLP 101
FG+L + + +N L+ P
Sbjct: 359 DHFGQLSRVGLWKIKDNPLIQPP 381
>gi|45439342 peptidylprolyl isomerase (cyclophilin)-like 5 isoform 1
[Homo sapiens]
Length = 414
Score = 61.2 bits (147), Expect = 1e-09
Identities = 35/78 (44%), Positives = 44/78 (56%), Gaps = 1/78 (1%)
Query: 44 LDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVS 103
LDLS NK+ LP FC L L L L N+L Q P G+L+NL+ L NKL LP
Sbjct: 231 LDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSE 290
Query: 104 FAQLKNLKWLDLKDNPLD 121
F L +L++LDL N +
Sbjct: 291 FRNL-SLEYLDLFGNTFE 307
Score = 53.1 bits (126), Expect = 3e-07
Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 4/105 (3%)
Query: 19 ELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLT---HLVKLDLSKNKLQ 75
+LDLS + + ++P + L L+L+ N L + C T L LDLSKNK++
Sbjct: 181 KLDLSHNHIKKLPAT-IGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIK 239
Query: 76 QLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
LP F +L L++L L +N+L+ P QL NL++L N L
Sbjct: 240 ALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKL 284
Score = 49.7 bits (117), Expect = 3e-06
Identities = 41/130 (31%), Positives = 55/130 (42%), Gaps = 37/130 (28%)
Query: 51 LTTLPSDFCGLTH----------LVKLDLSKNKLQQLPADFGRLVNLQH----------- 89
L L + +CGL L KLDLS N +++LPA G L++LQ
Sbjct: 156 LEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESF 215
Query: 90 ---------------LDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDE 134
LDL NK+ LPV F QL+ LK L L DN L K+ G ++
Sbjct: 216 SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKI-GQLINL 274
Query: 135 KQCKQCANKV 144
+ NK+
Sbjct: 275 RFLSAARNKL 284
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 60.8 bits (146), Expect = 1e-09
Identities = 26/82 (31%), Positives = 53/82 (64%)
Query: 154 DQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQ 213
++ER+ +R+ E +E E+K+E +++ +E +ER+ R+R++ EKE RKE + + KRE+
Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191
Query: 214 EKKPKKEANQAPKSKSGSRPRK 235
+K +K+ + + + + RK
Sbjct: 192 NRKERKKERERKERRERKKERK 213
Score = 59.3 bits (142), Expect = 4e-09
Identities = 31/79 (39%), Positives = 52/79 (65%), Gaps = 3/79 (3%)
Query: 157 RERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKK 216
RER+R +E +E +K+RE+ +R KE +ERE RKRE+ EKER+R+ K +R++E++
Sbjct: 39 REREREIETRKEGKKERES-ERKKERREREKRKRER--EKERKRERGKKEKKGERKKEER 95
Query: 217 PKKEANQAPKSKSGSRPRK 235
+K+ + ++K G K
Sbjct: 96 ERKKRRREKENKEGEEKEK 114
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/112 (31%), Positives = 61/112 (54%), Gaps = 5/112 (4%)
Query: 134 EKQCKQCANKVLQHMKAVQADQERERQRRLEVER---EAEKKREAKQRAKEAQERELRKR 190
+K+ K+ + + K + +ER+R+ R E ER E EK+RE K+R K +++ K
Sbjct: 116 KKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKE 175
Query: 191 EKAEEKER--RRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRK 240
E+ +EKER R+K K K+E+E+K ++E + K K + + R+
Sbjct: 176 EERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQ 227
Score = 53.1 bits (126), Expect = 3e-07
Identities = 33/86 (38%), Positives = 50/86 (58%), Gaps = 5/86 (5%)
Query: 154 DQERERQRRLE--VEREAEKKREAKQRAKEAQERE---LRKREKAEEKERRRKEYDALKA 208
++ERE + R E ERE+E+K+E ++R K +ERE R+R K E+K R+KE K
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99
Query: 209 AKREQEKKPKKEANQAPKSKSGSRPR 234
+RE+E K +E + K + R R
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGR 125
Score = 53.1 bits (126), Expect = 3e-07
Identities = 33/110 (30%), Positives = 62/110 (56%), Gaps = 9/110 (8%)
Query: 133 DEKQCKQCANKVLQHMKAVQADQERERQRRLEVER-------EAEKKREAKQRAKEAQER 185
+ K+ ++ + + K + ++ERER+ R + ER E K++E K+R K + R
Sbjct: 134 ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR 193
Query: 186 ELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRK 235
+ RK+E+ E KERR ++ + K +R++E++ ++ N K + G R RK
Sbjct: 194 KERKKER-ERKERRERKKERKKKEERKKERQKDRQTNWREKER-GKRERK 241
Score = 52.8 bits (125), Expect = 4e-07
Identities = 30/111 (27%), Positives = 64/111 (57%), Gaps = 3/111 (2%)
Query: 134 EKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKA 193
+K+ ++ NK + + + +++ER R + +E E+K E K+ +E +ERE +K E+
Sbjct: 98 KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR--EERKERERKKEERE 155
Query: 194 EEKERR-RKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTR 243
+E+ER+ RK+ + + ++E+E+K K+ + + ++ +K RK R
Sbjct: 156 KERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERR 206
Score = 51.6 bits (122), Expect = 9e-07
Identities = 30/93 (32%), Positives = 53/93 (56%), Gaps = 5/93 (5%)
Query: 155 QERERQRRLEVEREAEKKREAKQRAKEAQERELRKREK----AEEKERRRKEYDALKAAK 210
++R+R+R E +RE KK + +R KE +ER+ R+REK EEKE+R+K+ + + +
Sbjct: 67 EKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKK-EKKERGR 125
Query: 211 REQEKKPKKEANQAPKSKSGSRPRKPPPRKHTR 243
+E K ++ + + + R RK R+ R
Sbjct: 126 TSKEGKERERKEERKREERKERERKKEEREKER 158
Score = 50.8 bits (120), Expect = 1e-06
Identities = 29/91 (31%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 152 QADQERERQRRLE-VEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAK 210
+ +ERE +R+ E ERE K+ K+R +E ++E + K EE+ER+++ +
Sbjct: 50 EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEG 109
Query: 211 REQEKKPKKEANQAPK-SKSGSRPRKPPPRK 240
E+EK+ KKE + + SK G + RK
Sbjct: 110 EEKEKRKKKEKKERGRTSKEGKERERKEERK 140
Score = 50.8 bits (120), Expect = 1e-06
Identities = 35/120 (29%), Positives = 65/120 (54%), Gaps = 19/120 (15%)
Query: 134 EKQCKQCANKVLQHMKAVQADQERERQRRLE-------VEREAEKKREAKQR------AK 180
EK+ K+ K + K + +ERER++R E+E KK+E K+R K
Sbjct: 74 EKERKRERGK--KEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGK 131
Query: 181 EAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRK 240
E + +E RKRE+ +E+ER+++E + +RE++++ K+E Q + + + ++ RK
Sbjct: 132 ERERKEERKREERKERERKKEE----REKERERKERKKRERKQVGEKEEERKEKERKERK 187
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/99 (27%), Positives = 57/99 (57%), Gaps = 8/99 (8%)
Query: 152 QADQERERQRRLEVEREAEKKREAKQRAKEAQERELR------KREKAEEKERRRKEYDA 205
+ ++ER+R+R + E++ E+K+E ++R K +E+E + KR+K E+KER R +
Sbjct: 72 EREKERKRERG-KKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEG 130
Query: 206 LKAAKREQEKK-PKKEANQAPKSKSGSRPRKPPPRKHTR 243
+ ++E+ K+ +KE + + + R RK ++ +
Sbjct: 131 KERERKEERKREERKERERKKEEREKERERKERKKRERK 169
Score = 43.5 bits (101), Expect = 2e-04
Identities = 23/87 (26%), Positives = 51/87 (58%), Gaps = 1/87 (1%)
Query: 133 DEKQCKQCANKVLQHMKAVQADQER-ERQRRLEVEREAEKKREAKQRAKEAQERELRKRE 191
+ K+ K+ K + + + ++ER ER++R +E +K+RE K+R + +ER+ ++
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 192 KAEEKERRRKEYDALKAAKREQEKKPK 218
K E ++ R+ + + KRE++++ K
Sbjct: 219 KKERQKDRQTNWREKERGKRERKERKK 245
Score = 42.7 bits (99), Expect = 4e-04
Identities = 26/74 (35%), Positives = 45/74 (60%), Gaps = 4/74 (5%)
Query: 156 ERERQRRLEVEREAEKKREA--KQRAKEAQERELRKREKA-EEKERRRKEYDALKAAKRE 212
E+E +R+ E ER+ KKRE K+R KE + +E R+R+K ++KE R+KE +
Sbjct: 173 EKEEERK-EKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWR 231
Query: 213 QEKKPKKEANQAPK 226
++++ K+E + K
Sbjct: 232 EKERGKRERKERKK 245
Score = 42.4 bits (98), Expect = 5e-04
Identities = 21/88 (23%), Positives = 51/88 (57%), Gaps = 1/88 (1%)
Query: 134 EKQCKQCANKVLQHMKAVQADQER-ERQRRLEVEREAEKKREAKQRAKEAQERELRKREK 192
EK+ ++ K + + + ++ER E++R+ +RE +K K+R ++ + ++R+K
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKK 214
Query: 193 AEEKERRRKEYDALKAAKREQEKKPKKE 220
EE+++ R++ ++E+ K+ +KE
Sbjct: 215 KEERKKERQKDRQTNWREKERGKRERKE 242
Score = 40.4 bits (93), Expect = 0.002
Identities = 19/77 (24%), Positives = 44/77 (57%)
Query: 126 KVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQER 185
K G+ +E++ K+ + + + +ERER+ R E ++E +KK E K+ ++ ++
Sbjct: 169 KQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQT 228
Query: 186 ELRKREKAEEKERRRKE 202
R++E+ + + + RK+
Sbjct: 229 NWREKERGKRERKERKK 245
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 60.5 bits (145), Expect = 2e-09
Identities = 42/101 (41%), Positives = 53/101 (52%), Gaps = 1/101 (0%)
Query: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
LDLS + L+ +P K A L K T + LS N+L +P C T L L L L +L
Sbjct: 239 LDLSHNLLHSIP-KSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRG 297
Query: 80 DFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
F LVNL+ LDL N L P+ LKNL+ L L DN +
Sbjct: 298 SFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKI 338
Score = 56.6 bits (135), Expect = 3e-08
Identities = 35/95 (36%), Positives = 51/95 (53%)
Query: 29 EVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQ 88
EV +EL L I+DL NK+ +P + LT L K ++ N L LPA + L
Sbjct: 178 EVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLS 237
Query: 89 HLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPV 123
LDL +N L ++P SFA+L+ + + L N L+ V
Sbjct: 238 VLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272
Score = 55.1 bits (131), Expect = 8e-08
Identities = 39/128 (30%), Positives = 53/128 (41%), Gaps = 23/128 (17%)
Query: 19 ELDLSLSDLNEVPV----------------KELAALPKATI-------LDLSCNKLTTLP 55
EL L +DL E+PV L LPK + + L N+ P
Sbjct: 122 ELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
Query: 56 SDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDL 115
+ C L L +DL +NK+ +P + G L LQ + +N L LP S Q L LDL
Sbjct: 182 QELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDL 241
Query: 116 KDNPLDPV 123
N L +
Sbjct: 242 SHNLLHSI 249
Score = 52.0 bits (123), Expect = 7e-07
Identities = 35/95 (36%), Positives = 51/95 (53%), Gaps = 2/95 (2%)
Query: 28 NEVPV--KELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLV 85
N +PV L + ++LDLS N L ++P F L + ++ LS N+L+++P R
Sbjct: 221 NNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWT 280
Query: 86 NLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL 120
+L L L N L L SF L NL++LDL N L
Sbjct: 281 SLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHL 315
Score = 51.6 bits (122), Expect = 9e-07
Identities = 68/274 (24%), Positives = 104/274 (37%), Gaps = 56/274 (20%)
Query: 9 GNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLD 68
G+ R ++ LDLS + L+ P+ ++ AL +L L NK+ LPS+ L+ L L
Sbjct: 297 GSFRCLVNLRFLDLSQNHLHHCPL-QICALKNLEVLGLDDNKIGQLPSELGSLSKLKILG 355
Query: 69 LSKN--------------------------KLQQLPADFGRLVNLQHLDLLNNKLVTLPV 102
L+ N KL +P +L +L+ L + NN L LPV
Sbjct: 356 LTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPV 415
Query: 103 SFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQC---KQCANKVLQHMKAVQADQERER 159
S + NL+ LD + N L K D + + Q + + +L H+ +
Sbjct: 416 SLGSMPNLEVLDCRHN-----LLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLK 470
Query: 160 QRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKA----------- 208
L E +E EA + L KE R + A K
Sbjct: 471 VLTLMDNPMEEPPKEVCAEGNEAIWKYL--------KENRNRNIMATKIQAWWRGTMVQR 522
Query: 209 --AKREQEKKPKKEANQAPKSKSGSRPRKPPPRK 240
K + KP+K+ +PK K G + K P K
Sbjct: 523 GFGKFGELLKPQKKGKTSPKDKKGKKDVKGKPGK 556
Score = 46.2 bits (108), Expect = 4e-05
Identities = 25/77 (32%), Positives = 43/77 (55%)
Query: 44 LDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVS 103
+D S LT +P + T L ++ L N+++++P + RL N++ L L N L +L +
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 104 FAQLKNLKWLDLKDNPL 120
L +L+ LDL NP+
Sbjct: 90 LGLLSSLESLDLSYNPI 106
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,088,849
Number of Sequences: 37866
Number of extensions: 581813
Number of successful extensions: 23994
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 847
Number of HSP's successfully gapped in prelim test: 843
Number of HSP's that attempted gapping in prelim test: 6222
Number of HSP's gapped (non-prelim): 9713
length of query: 307
length of database: 18,247,518
effective HSP length: 102
effective length of query: 205
effective length of database: 14,385,186
effective search space: 2948963130
effective search space used: 2948963130
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.