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Search of human proteins with 40254851
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40254851 protein kinase PKNbeta [Homo sapiens]
(889 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40254851 protein kinase PKNbeta [Homo sapiens] 1799 0.0
gi|5453974 protein kinase N2 [Homo sapiens] 877 0.0
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 867 0.0
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 867 0.0
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 303 4e-82
gi|4506067 protein kinase C, alpha [Homo sapiens] 298 2e-80
gi|4502023 AKT2 kinase [Homo sapiens] 297 3e-80
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 294 3e-79
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 294 3e-79
gi|13384594 protein kinase C, gamma [Homo sapiens] 291 1e-78
gi|47157325 protein kinase C, delta [Homo sapiens] 291 2e-78
gi|31377782 protein kinase C, delta [Homo sapiens] 291 2e-78
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 289 7e-78
gi|4885563 protein kinase C, epsilon [Homo sapiens] 287 3e-77
gi|28557781 protein kinase C, eta [Homo sapiens] 286 8e-77
gi|62241015 AKT1 kinase [Homo sapiens] 286 8e-77
gi|62241013 AKT1 kinase [Homo sapiens] 286 8e-77
gi|62241011 AKT1 kinase [Homo sapiens] 286 8e-77
gi|5453976 protein kinase C, theta [Homo sapiens] 283 7e-76
gi|133908623 protein kinase C, iota [Homo sapiens] 273 4e-73
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 267 4e-71
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 267 4e-71
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 267 4e-71
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 265 2e-70
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 261 2e-69
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 261 2e-69
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 261 2e-69
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 261 2e-69
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 260 3e-69
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 258 2e-68
>gi|40254851 protein kinase PKNbeta [Homo sapiens]
Length = 889
Score = 1799 bits (4660), Expect = 0.0
Identities = 889/889 (100%), Positives = 889/889 (100%)
Query: 1 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS 60
MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS
Sbjct: 1 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSS 60
Query: 61 NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV 120
NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV
Sbjct: 61 NRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKV 120
Query: 121 KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA 180
KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA
Sbjct: 121 KQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLA 180
Query: 181 EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL 240
EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL
Sbjct: 181 EELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLL 240
Query: 241 EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP 300
EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP
Sbjct: 241 EQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSP 300
Query: 301 AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI 360
AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI
Sbjct: 301 AAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVI 360
Query: 361 PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI 420
PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI
Sbjct: 361 PLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVI 420
Query: 421 ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT 480
ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT
Sbjct: 421 ERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRT 480
Query: 481 PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR 540
PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR
Sbjct: 481 PTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTR 540
Query: 541 RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE 600
RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE
Sbjct: 541 RGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDE 600
Query: 601 IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ 660
IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ
Sbjct: 601 IESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQ 660
Query: 661 ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC 720
ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC
Sbjct: 661 ARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFC 720
Query: 721 GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG 780
GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG
Sbjct: 721 GTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPG 780
Query: 781 FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLC 840
FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLC
Sbjct: 781 FLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLC 840
Query: 841 GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP 889
GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP
Sbjct: 841 GPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP 889
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 877 bits (2267), Expect = 0.0
Identities = 478/943 (50%), Positives = 621/943 (65%), Gaps = 81/943 (8%)
Query: 17 EDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHA 76
+D K+ I+R I+KELKIKEG ENLR+V TD++ L +V +L+ SN++LE+LH +L+EL+A
Sbjct: 46 DDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNA 105
Query: 77 RILLPGPGP---GPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCAS 133
I++ P P P P R L+AL++QL +ELKVKQGAENM ++
Sbjct: 106 HIVVSDPEDITDCPRTPDTPNNDPRCSTSNNR-LKALQKQLDIELKVKQGAENMIQMYSN 164
Query: 134 GTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEA---------SGSPEPGP-ELLAEEL 183
G+ K+RKL AQQ+L+DS+ K+ ++RM+I L+A + P P EL EEL
Sbjct: 165 GSSKDRKLHGTAQQLLQDSKTKIEVIRMQI--LQAVQTNELAFDNAKPVISPLELRMEEL 222
Query: 184 QHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQL 243
+H +E AVAEGAKNV+KLL S + DRKAL+EAQA+ ESSQKLDLL+ +LEQ L ++
Sbjct: 223 RHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEV 282
Query: 244 PPAHPLRSRVTRELRAAVPGYPQPS------------GTPVKPTALTGTLQVRLLGCEQL 291
P HP +SR+ E + V P S T KP ALTGTL+VRL+GC+ +
Sbjct: 283 PKNHP-KSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDI 341
Query: 292 LTAVPGRSPAAALAS---SPSE---GWLRTKAKHQRGRG-------ELASEVLAVLKVDN 338
L VPGRS A ++A SPSE ++ +K + G +L+++V AVLK+DN
Sbjct: 342 LENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDN 401
Query: 339 RVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQ 398
VVGQT W ++ QSWDQ F + L+R+RELEI V+WRDWR LC V FLRLEDFLDN H
Sbjct: 402 TVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHG 461
Query: 399 LSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLV 458
+ L L PQG LFA+VTF +PVIERRP+LQRQ++IFSK++G+ FLRA QMN+ +A WGRLV
Sbjct: 462 MCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLV 521
Query: 459 MNLLPPCSSPSTISP----PKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPP 514
+P + T SP P P + + + PA+ S K E PPP PP
Sbjct: 522 RRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVT--KLDFDLEPEPPPAPP 579
Query: 515 R---------------LYLPQEPT------------------SEETPRTKRPHMEPRTRR 541
R L +P + + SE P T + +E +
Sbjct: 580 RASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQ 639
Query: 542 GPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEI 601
S R LQDFRC AVLGRGHFGKVLL ++K T + +AIKALKK ++++RDE+
Sbjct: 640 ELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEV 699
Query: 602 ESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQA 661
+SL CEKRI E V HPFL++L ACFQT H CFV E+ GGDLMM IH DVF EP+A
Sbjct: 700 DSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRA 759
Query: 662 RFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCG 721
FY ACVVLGLQ+LHE KI+YRDLKLDNLLLD +GF+KIADFGLCKEG+G+GDRTSTFCG
Sbjct: 760 VFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCG 819
Query: 722 TPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGF 781
TPEFLAPEVLT+ +YTRAVDWWGLGVL+YEMLVGE PFPGD EEEVFD IVN + YP F
Sbjct: 820 TPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRF 879
Query: 782 LSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCG 841
LS + + +++LL++ PE+RLGA E+DAE++K PFFR +W AL+ + ++PPF+PT+ G
Sbjct: 880 LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRG 939
Query: 842 PADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSE 884
D+ F+ EFT P LTPP +L+ +Q FRDFD++++
Sbjct: 940 REDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIAD 982
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 867 bits (2241), Expect = 0.0
Identities = 480/917 (52%), Positives = 608/917 (66%), Gaps = 63/917 (6%)
Query: 17 EDEKEVIRRAIQKELKIKEGVENLRRVATDR-RHLGHVQQLLRSSNRRLEQLHGELRELH 75
E E+E +RR I+KELK+KEG ENLRR TD R LG V+ LLR S+RRL+ LH +L+ELH
Sbjct: 42 ELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELH 101
Query: 76 ARILLPGPGP---GPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCA 132
A ++LP P GP P A GP A L + L +QL +ELKVKQGAENM T +
Sbjct: 102 AHVVLPDPAATHDGPQSPGAGGPTCSATNLS--RVAGLEKQLAIELKVKQGAENMIQTYS 159
Query: 133 SGTPKERKLLAAAQQMLRDSQLKVALLRMKISSL-------------EASGSPEPGP-EL 178
+G+ K+RKLL AQQML+DS+ K+ ++RM++ + GSP+ G EL
Sbjct: 160 NGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVEL 219
Query: 179 LAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQ 238
EEL+H VE AVAEGAKNV++LLS+ + DRKA++EAQ +L ES+QKL LLR ALE+
Sbjct: 220 RIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALER 279
Query: 239 LLEQLPPAHPLRSRVTRELRAAVPGY-------PQPS---GTPVKPTALTGTLQVRLLGC 288
L +LP HP + EL AA P P+ T KP LTGTL+VR++GC
Sbjct: 280 RLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGC 339
Query: 289 EQLLTAVPGRSPAAALA------------SSPSEGWLRTKAKHQRGRGEL------ASEV 330
L +P +P ++ S P+ G L +++ GR L SEV
Sbjct: 340 RDLPETIPW-NPTPSMGGPGTPDSRPPFLSRPARG-LYSRSGSLSGRSSLKAEAENTSEV 397
Query: 331 LAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLED 390
VLK+DN VVGQT W +WDQ+F + LERARELE+ V WRD R LC + FL+LED
Sbjct: 398 STVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLED 457
Query: 391 FLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLG 450
FLDN H++ L + PQG L A+VTF +PVIER PRL+RQ++IFSK++G+ F RA QMN+
Sbjct: 458 FLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNID 517
Query: 451 MAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPP 510
+A W RL+ L+P + T SP S+ T + +K LG +
Sbjct: 518 VATWVRLLRRLIPNATGTGTFSPGAS---------PGSEARTTGDISVEKLNLGTDSDSS 568
Query: 511 PKPPRLYLPQEPTSEETP--RTKRPHMEPRTRRGPSPP-ASPTRKPP-RLQDFRCLAVLG 566
P+ P P+S +P + P + T+ P P SP RK P L+DF+ LAVLG
Sbjct: 569 PQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLG 628
Query: 567 RGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLL 626
RGHFGKVLL +F+ +G+ +AIKALKK ++++RDE+ESL CEKRIL AV GHPFL++L
Sbjct: 629 RGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLF 688
Query: 627 ACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLK 686
CFQT H CFV E+ GGDLM+ IH DVF EP+A FY ACVVLGLQFLHE KI+YRDLK
Sbjct: 689 GCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLK 748
Query: 687 LDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLG 746
LDNLLLD +G++KIADFGLCKEG+G+GDRTSTFCGTPEFLAPEVLT +YTRAVDWWGLG
Sbjct: 749 LDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLG 808
Query: 747 VLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGE 806
VLLYEMLVGE PFPGD EEEVFD IVN + YP FLS + + +++LL++ PE+RLG+ E
Sbjct: 809 VLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSE 868
Query: 807 QDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHS 866
+DAE++K QPFFRT W+ALLAR + PPFVPTL G D+ F+ EFTG P L+PP
Sbjct: 869 RDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDAR 928
Query: 867 LLTARQQAAFRDFDFVS 883
LTA +QAAF DFDFV+
Sbjct: 929 PLTAAEQAAFLDFDFVA 945
Score = 71.6 bits (174), Expect = 3e-12
Identities = 51/165 (30%), Positives = 81/165 (49%), Gaps = 24/165 (14%)
Query: 97 PWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKV 156
P +Q E LRR++ ELK+K+GAEN+ T + L + +LR S ++
Sbjct: 35 PGVQQQLELERERLRREIRKELKLKEGAENLRR----ATTDLGRSLGPVELLLRGSSRRL 90
Query: 157 ALLRMKISSLEA-----------SGSPEP---GPELLAEE------LQHRLHVEAAVAEG 196
LL ++ L A G P GP A L+ +L +E V +G
Sbjct: 91 DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQG 150
Query: 197 AKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLE 241
A+N+++ S+ T+DRK L AQ LQ+S K+D++R+ L + L+
Sbjct: 151 AENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQ 195
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 867 bits (2241), Expect = 0.0
Identities = 480/917 (52%), Positives = 608/917 (66%), Gaps = 63/917 (6%)
Query: 17 EDEKEVIRRAIQKELKIKEGVENLRRVATDR-RHLGHVQQLLRSSNRRLEQLHGELRELH 75
E E+E +RR I+KELK+KEG ENLRR TD R LG V+ LLR S+RRL+ LH +L+ELH
Sbjct: 36 ELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELH 95
Query: 76 ARILLPGPGP---GPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCA 132
A ++LP P GP P A GP A L + L +QL +ELKVKQGAENM T +
Sbjct: 96 AHVVLPDPAATHDGPQSPGAGGPTCSATNLS--RVAGLEKQLAIELKVKQGAENMIQTYS 153
Query: 133 SGTPKERKLLAAAQQMLRDSQLKVALLRMKISSL-------------EASGSPEPGP-EL 178
+G+ K+RKLL AQQML+DS+ K+ ++RM++ + GSP+ G EL
Sbjct: 154 NGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVEL 213
Query: 179 LAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQ 238
EEL+H VE AVAEGAKNV++LLS+ + DRKA++EAQ +L ES+QKL LLR ALE+
Sbjct: 214 RIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALER 273
Query: 239 LLEQLPPAHPLRSRVTRELRAAVPGY-------PQPS---GTPVKPTALTGTLQVRLLGC 288
L +LP HP + EL AA P P+ T KP LTGTL+VR++GC
Sbjct: 274 RLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGC 333
Query: 289 EQLLTAVPGRSPAAALA------------SSPSEGWLRTKAKHQRGRGEL------ASEV 330
L +P +P ++ S P+ G L +++ GR L SEV
Sbjct: 334 RDLPETIPW-NPTPSMGGPGTPDSRPPFLSRPARG-LYSRSGSLSGRSSLKAEAENTSEV 391
Query: 331 LAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLED 390
VLK+DN VVGQT W +WDQ+F + LERARELE+ V WRD R LC + FL+LED
Sbjct: 392 STVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLED 451
Query: 391 FLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLG 450
FLDN H++ L + PQG L A+VTF +PVIER PRL+RQ++IFSK++G+ F RA QMN+
Sbjct: 452 FLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNID 511
Query: 451 MAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPP 510
+A W RL+ L+P + T SP S+ T + +K LG +
Sbjct: 512 VATWVRLLRRLIPNATGTGTFSPGAS---------PGSEARTTGDISVEKLNLGTDSDSS 562
Query: 511 PKPPRLYLPQEPTSEETP--RTKRPHMEPRTRRGPSPP-ASPTRKPP-RLQDFRCLAVLG 566
P+ P P+S +P + P + T+ P P SP RK P L+DF+ LAVLG
Sbjct: 563 PQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLG 622
Query: 567 RGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLL 626
RGHFGKVLL +F+ +G+ +AIKALKK ++++RDE+ESL CEKRIL AV GHPFL++L
Sbjct: 623 RGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLF 682
Query: 627 ACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLK 686
CFQT H CFV E+ GGDLM+ IH DVF EP+A FY ACVVLGLQFLHE KI+YRDLK
Sbjct: 683 GCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLK 742
Query: 687 LDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLG 746
LDNLLLD +G++KIADFGLCKEG+G+GDRTSTFCGTPEFLAPEVLT +YTRAVDWWGLG
Sbjct: 743 LDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLG 802
Query: 747 VLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGE 806
VLLYEMLVGE PFPGD EEEVFD IVN + YP FLS + + +++LL++ PE+RLG+ E
Sbjct: 803 VLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSE 862
Query: 807 QDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHS 866
+DAE++K QPFFRT W+ALLAR + PPFVPTL G D+ F+ EFTG P L+PP
Sbjct: 863 RDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDAR 922
Query: 867 LLTARQQAAFRDFDFVS 883
LTA +QAAF DFDFV+
Sbjct: 923 PLTAAEQAAFLDFDFVA 939
Score = 71.6 bits (174), Expect = 3e-12
Identities = 51/165 (30%), Positives = 81/165 (49%), Gaps = 24/165 (14%)
Query: 97 PWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKV 156
P +Q E LRR++ ELK+K+GAEN+ T + L + +LR S ++
Sbjct: 29 PGVQQQLELERERLRREIRKELKLKEGAENLRR----ATTDLGRSLGPVELLLRGSSRRL 84
Query: 157 ALLRMKISSLEA-----------SGSPEP---GPELLAEE------LQHRLHVEAAVAEG 196
LL ++ L A G P GP A L+ +L +E V +G
Sbjct: 85 DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQG 144
Query: 197 AKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLE 241
A+N+++ S+ T+DRK L AQ LQ+S K+D++R+ L + L+
Sbjct: 145 AENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQ 189
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 303 bits (777), Expect = 4e-82
Identities = 157/336 (46%), Positives = 210/336 (62%), Gaps = 5/336 (1%)
Query: 555 RLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAV 614
+L DF L VLG+G FGKV+L + KGT + YA+K LKK V+ D++E EKR+L
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 615 GCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQ 673
G PFL L +CFQT FV E+V GGDLM I + F EP A FY A + +GL
Sbjct: 398 GKP--PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
Query: 674 FLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQ 733
FL K IIYRDLKLDN++LD++G +KIADFG+CKE I G T TFCGTP+++APE++
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515
Query: 734 EAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKL 793
+ Y ++VDWW GVLLYEML G+ PF G+ E+E+F I+ + YP +S + + + L
Sbjct: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 794 LQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT 853
+ K P KRLG G + +IK FFR +W+ L + IQPP+ P CG + F+ FT
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFT 634
Query: 854 GLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP 889
PP LTPP ++ Q+ F F FV+ FL+P
Sbjct: 635 RHPPVLTPP-DQEVIRNIDQSEFEGFSFVNSEFLKP 669
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 298 bits (763), Expect = 2e-80
Identities = 164/378 (43%), Positives = 226/378 (59%), Gaps = 14/378 (3%)
Query: 520 QEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPP-------RLQDFRCLAVLGRGHFGK 572
+E E + ++ + P + SP S RK P +L DF L VLG+G FGK
Sbjct: 295 EEGNMELRQKFEKAKLGPAGNKVISP--SEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGK 352
Query: 573 VLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTS 632
V+L KGT + YAIK LKK V+ D++E EKR+L + PFL L +CFQT
Sbjct: 353 VMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP--PFLTQLHSCFQTV 410
Query: 633 SHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLL 691
FV E+V GGDLM I + F EPQA FY A + +GL FLH++ IIYRDLKLDN++
Sbjct: 411 DRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVM 470
Query: 692 LDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYE 751
LD++G +KIADFG+CKE + G T TFCGTP+++APE++ + Y ++VDWW GVLLYE
Sbjct: 471 LDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYE 530
Query: 752 MLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEE 811
ML G+ PF G+ E+E+F I+ + YP LS + + + L+ K P KRLG G + +
Sbjct: 531 MLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERD 590
Query: 812 IKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTAR 871
++ FFR +W+ L R IQPPF P +CG F+ FT P LTPP ++
Sbjct: 591 VREHAFFRRIDWEKLENREIQPPFKPKVCGKG-AENFDKFFTRGQPVLTPP-DQLVIANI 648
Query: 872 QQAAFRDFDFVSERFLEP 889
Q+ F F +V+ +F+ P
Sbjct: 649 DQSDFEGFSYVNPQFVHP 666
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 297 bits (760), Expect = 3e-80
Identities = 150/338 (44%), Positives = 208/338 (61%), Gaps = 7/338 (2%)
Query: 548 SPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCE 607
S R + DF L +LG+G FGKV+LV+ K TG+YYA+K L+K+ ++++DE+ E
Sbjct: 141 SKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE 200
Query: 608 KRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQI-HEDVFPEPQARFYVA 666
R+L+ T HPFL +L FQT CFV E+ GG+L + E VF E +ARFY A
Sbjct: 201 SRVLQN---TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGA 257
Query: 667 CVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFL 726
+V L++LH + ++YRD+KL+NL+LD G +KI DFGLCKEGI G TFCGTPE+L
Sbjct: 258 EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYL 317
Query: 727 APEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQG 786
APEVL Y RAVDWWGLGV++YEM+ G PF E +F+ I+ + +P LS +
Sbjct: 318 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEA 377
Query: 787 LEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLR 846
+ LL+K P++RLG G DA+E+ FF + NWQ ++ + + PPF P + D R
Sbjct: 378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTR 437
Query: 847 YFEGEFTGLPPALTPPAPH---SLLTARQQAAFRDFDF 881
YF+ EFT +TPP + LL Q+ F F +
Sbjct: 438 YFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 294 bits (752), Expect = 3e-79
Identities = 151/312 (48%), Positives = 193/312 (61%), Gaps = 4/312 (1%)
Query: 552 KPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRIL 611
K + DF L +LG+G FGKV+LV+ K +GKYYA+K LKK+ ++++DE+ E R+L
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200
Query: 612 EAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQI-HEDVFPEPQARFYVACVVL 670
+ T HPFL SL FQT CFV E+V GG+L + E VF E + RFY A +V
Sbjct: 201 KN---TRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
Query: 671 GLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEV 730
L +LH KI+YRDLKL+NL+LD G +KI DFGLCKEGI TFCGTPE+LAPEV
Sbjct: 258 ALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEV 317
Query: 731 LTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFI 790
L Y RAVDWWGLGV++YEM+ G PF E++F+ I+ D +P LS +
Sbjct: 318 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 791 QKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEG 850
LL K P KRLG G DA+EI FF NWQ + + + PPF P + D RYF+
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDE 437
Query: 851 EFTGLPPALTPP 862
EFT +TPP
Sbjct: 438 EFTAQTITITPP 449
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 294 bits (752), Expect = 3e-79
Identities = 151/312 (48%), Positives = 193/312 (61%), Gaps = 4/312 (1%)
Query: 552 KPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRIL 611
K + DF L +LG+G FGKV+LV+ K +GKYYA+K LKK+ ++++DE+ E R+L
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200
Query: 612 EAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQI-HEDVFPEPQARFYVACVVL 670
+ T HPFL SL FQT CFV E+V GG+L + E VF E + RFY A +V
Sbjct: 201 KN---TRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
Query: 671 GLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEV 730
L +LH KI+YRDLKL+NL+LD G +KI DFGLCKEGI TFCGTPE+LAPEV
Sbjct: 258 ALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEV 317
Query: 731 LTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFI 790
L Y RAVDWWGLGV++YEM+ G PF E++F+ I+ D +P LS +
Sbjct: 318 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 791 QKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEG 850
LL K P KRLG G DA+EI FF NWQ + + + PPF P + D RYF+
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDE 437
Query: 851 EFTGLPPALTPP 862
EFT +TPP
Sbjct: 438 EFTAQTITITPP 449
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 291 bits (746), Expect = 1e-78
Identities = 165/373 (44%), Positives = 218/373 (58%), Gaps = 16/373 (4%)
Query: 531 KRPHMEPRTRRGPSPPASPT--------RKPPRLQ--DFRCLAVLGRGHFGKVLLVQFKG 580
+R M P + PSP SPT P RL DF L VLG+G FGKV+L + +G
Sbjct: 313 ERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRG 372
Query: 581 TGKYYAIKALKKQEVLSRDEIESLYCEKRILE--AVGCTGHP-FLLSLLACFQTSSHACF 637
+ + YAIK LKK ++ D+++ EKR+L G G P FL L + FQT F
Sbjct: 373 SDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYF 432
Query: 638 VTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQG 696
V E+V GGDLM I + F EP A FY A + +GL FLH + IIYRDLKLDN++LDA+G
Sbjct: 433 VMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEG 492
Query: 697 FLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGE 756
+KI DFG+CKE + G T TFCGTP+++APE++ + Y ++VDWW GVLLYEML G+
Sbjct: 493 HIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQ 552
Query: 757 CPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQP 816
PF G+ EEE+F I+ YP LS + + + L K P KRLG+G I+
Sbjct: 553 PPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHG 612
Query: 817 FFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAF 876
FFR +W+ L I PPF P CG + F+ FT PALTPP +L + QA F
Sbjct: 613 FFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALTPP-DRLVLASIDQADF 670
Query: 877 RDFDFVSERFLEP 889
+ F +V+ F+ P
Sbjct: 671 QGFTYVNPDFVHP 683
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 291 bits (745), Expect = 2e-78
Identities = 157/325 (48%), Positives = 208/325 (64%), Gaps = 10/325 (3%)
Query: 564 VLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLL 623
VLG+G FGKVLL + KG G+Y+AIKALKK VL D++E EKR+L +PFL
Sbjct: 354 VLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAA--ENPFLT 411
Query: 624 SLLACFQTSSHACFVTEFVPGGDLMMQIHEDV-FPEPQARFYVACVVLGLQFLHEKKIIY 682
L+ FQT H FV EF+ GGDLM I + F +A FY A ++ GLQFLH K IIY
Sbjct: 412 HLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIY 471
Query: 683 RDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDW 742
RDLKLDN+LLD G +KIADFG+CKE I R STFCGTP+++APE+L YT +VDW
Sbjct: 472 RDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDW 531
Query: 743 WGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAP-YPGFLSVQGLEFIQKLLQKCPEKR 801
W GVLLYEML+G+ PF GD E+E+F+ I +D P YP +++ + + ++KL ++ P KR
Sbjct: 532 WSFGVLLYEMLIGQSPFHGDDEDELFESI-RVDTPHYPRWITKESKDILEKLFEREPTKR 590
Query: 802 LGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTP 861
LG IK+ PFF+T NW L R ++PPF P + P D F+ EF L+
Sbjct: 591 LGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLS- 645
Query: 862 PAPHSLLTARQQAAFRDFDFVSERF 886
+ +L+ + Q+AF F FV+ +F
Sbjct: 646 YSDKNLIDSMDQSAFAGFSFVNPKF 670
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 291 bits (745), Expect = 2e-78
Identities = 157/325 (48%), Positives = 208/325 (64%), Gaps = 10/325 (3%)
Query: 564 VLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLL 623
VLG+G FGKVLL + KG G+Y+AIKALKK VL D++E EKR+L +PFL
Sbjct: 354 VLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAA--ENPFLT 411
Query: 624 SLLACFQTSSHACFVTEFVPGGDLMMQIHEDV-FPEPQARFYVACVVLGLQFLHEKKIIY 682
L+ FQT H FV EF+ GGDLM I + F +A FY A ++ GLQFLH K IIY
Sbjct: 412 HLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIY 471
Query: 683 RDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDW 742
RDLKLDN+LLD G +KIADFG+CKE I R STFCGTP+++APE+L YT +VDW
Sbjct: 472 RDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDW 531
Query: 743 WGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAP-YPGFLSVQGLEFIQKLLQKCPEKR 801
W GVLLYEML+G+ PF GD E+E+F+ I +D P YP +++ + + ++KL ++ P KR
Sbjct: 532 WSFGVLLYEMLIGQSPFHGDDEDELFESI-RVDTPHYPRWITKESKDILEKLFEREPTKR 590
Query: 802 LGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTP 861
LG IK+ PFF+T NW L R ++PPF P + P D F+ EF L+
Sbjct: 591 LGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLS- 645
Query: 862 PAPHSLLTARQQAAFRDFDFVSERF 886
+ +L+ + Q+AF F FV+ +F
Sbjct: 646 YSDKNLIDSMDQSAFAGFSFVNPKF 670
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 289 bits (740), Expect = 7e-78
Identities = 151/334 (45%), Positives = 203/334 (60%), Gaps = 4/334 (1%)
Query: 555 RLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAV 614
+L DF L VLG+G FGKV+L + KGT + YA+K LKK V+ D++E EKR+L
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 615 GCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQ 673
G PFL L +CFQT FV E+V GGDLM I + F EP A FY A + +GL
Sbjct: 398 GKP--PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455
Query: 674 FLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQ 733
FL K IIYRDLKLDN++LD++G +KIADFG+CKE I G T TFCGTP+++APE++
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515
Query: 734 EAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKL 793
+ Y ++VDWW GVLLYEML G+ PF G+ E+E+F I+ + YP +S + + + L
Sbjct: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 794 LQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT 853
+ K P KRLG G + +IK FFR +W+ L + IQPP+ P D F+ EFT
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFT 635
Query: 854 GLPPALTPPAPHSLLTARQQAAFRDFDFVSERFL 887
P LTP ++ Q F F + + F+
Sbjct: 636 RQPVELTPTDKLFIMNL-DQNEFAGFSYTNPEFV 668
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 287 bits (735), Expect = 3e-77
Identities = 147/332 (44%), Positives = 205/332 (61%), Gaps = 6/332 (1%)
Query: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
L +F + VLG+G FGKV+L + KG + YA+K LKK +L D+++ EKRIL
Sbjct: 405 LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALA- 463
Query: 616 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHED-VFPEPQARFYVACVVLGLQF 674
HP+L L CFQT FV E+V GGDLM QI F EP++RFY A V L F
Sbjct: 464 -RKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMF 522
Query: 675 LHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQE 734
LH+ +IYRDLKLDN+LLDA+G K+ADFG+CKEGI G T+TFCGTP+++APE+L +
Sbjct: 523 LHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQEL 582
Query: 735 AYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLL 794
Y +VDWW LGVL+YEM+ G+ PF D E+++F+ I++ D YP +LS + + ++ +
Sbjct: 583 EYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFM 642
Query: 795 QKCPEKRLG--AGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEF 852
K P KRLG A + + IK PFF+ +W L + I+PPF P + D+ F+ +F
Sbjct: 643 TKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDF 702
Query: 853 TGLPPALTPPAPHSLLTARQQAAFRDFDFVSE 884
T P LT +++ Q F+ F + E
Sbjct: 703 TREEPVLT-LVDEAIVKQINQEEFKGFSYFGE 733
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 286 bits (731), Expect = 8e-77
Identities = 152/330 (46%), Positives = 199/330 (60%), Gaps = 5/330 (1%)
Query: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
+ +F + VLG+G FGKV+L + K TG YA+K LKK +L D++E EKRIL
Sbjct: 352 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLA- 410
Query: 616 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDV-FPEPQARFYVACVVLGLQF 674
HPFL L CFQT FV EFV GGDLM I + F E +ARFY A ++ L F
Sbjct: 411 -RNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMF 469
Query: 675 LHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQE 734
LH+K IIYRDLKLDN+LLD +G K+ADFG+CKEGI G T+TFCGTP+++APE+L +
Sbjct: 470 LHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM 529
Query: 735 AYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLL 794
Y AVDWW +GVLLYEML G PF + E+++F+ I+N + YP +L ++ +
Sbjct: 530 LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM 589
Query: 795 QKCPEKRLGAGEQDAEE-IKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT 853
K P RLG+ Q E I PFF+ +W L R I+PPF P + D+ F+ +F
Sbjct: 590 TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFI 649
Query: 854 GLPPALTPPAPHSLLTARQQAAFRDFDFVS 883
P LT P L Q FR+F +VS
Sbjct: 650 KEEPVLT-PIDEGHLPMINQDEFRNFSYVS 678
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 286 bits (731), Expect = 8e-77
Identities = 144/309 (46%), Positives = 196/309 (63%), Gaps = 5/309 (1%)
Query: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
+ +F L +LG+G FGKV+LV+ K TG+YYA+K LKK+ ++++DE+ E R+L+
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN-- 204
Query: 616 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQI-HEDVFPEPQARFYVACVVLGLQF 674
+ HPFL +L FQT CFV E+ GG+L + E VF E +ARFY A +V L +
Sbjct: 205 -SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263
Query: 675 LH-EKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQ 733
LH EK ++YRDLKL+NL+LD G +KI DFGLCKEGI G TFCGTPE+LAPEVL
Sbjct: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323
Query: 734 EAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKL 793
Y RAVDWWGLGV++YEM+ G PF E++F+ I+ + +P L + + L
Sbjct: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383
Query: 794 LQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT 853
L+K P++RLG G +DA+EI FF WQ + + + PPF P + D RYF+ EFT
Sbjct: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443
Query: 854 GLPPALTPP 862
+TPP
Sbjct: 444 AQMITITPP 452
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 286 bits (731), Expect = 8e-77
Identities = 144/309 (46%), Positives = 196/309 (63%), Gaps = 5/309 (1%)
Query: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
+ +F L +LG+G FGKV+LV+ K TG+YYA+K LKK+ ++++DE+ E R+L+
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN-- 204
Query: 616 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQI-HEDVFPEPQARFYVACVVLGLQF 674
+ HPFL +L FQT CFV E+ GG+L + E VF E +ARFY A +V L +
Sbjct: 205 -SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263
Query: 675 LH-EKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQ 733
LH EK ++YRDLKL+NL+LD G +KI DFGLCKEGI G TFCGTPE+LAPEVL
Sbjct: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323
Query: 734 EAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKL 793
Y RAVDWWGLGV++YEM+ G PF E++F+ I+ + +P L + + L
Sbjct: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383
Query: 794 LQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT 853
L+K P++RLG G +DA+EI FF WQ + + + PPF P + D RYF+ EFT
Sbjct: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443
Query: 854 GLPPALTPP 862
+TPP
Sbjct: 444 AQMITITPP 452
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 286 bits (731), Expect = 8e-77
Identities = 144/309 (46%), Positives = 196/309 (63%), Gaps = 5/309 (1%)
Query: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
+ +F L +LG+G FGKV+LV+ K TG+YYA+K LKK+ ++++DE+ E R+L+
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN-- 204
Query: 616 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQI-HEDVFPEPQARFYVACVVLGLQF 674
+ HPFL +L FQT CFV E+ GG+L + E VF E +ARFY A +V L +
Sbjct: 205 -SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 263
Query: 675 LH-EKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQ 733
LH EK ++YRDLKL+NL+LD G +KI DFGLCKEGI G TFCGTPE+LAPEVL
Sbjct: 264 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 323
Query: 734 EAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKL 793
Y RAVDWWGLGV++YEM+ G PF E++F+ I+ + +P L + + L
Sbjct: 324 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGL 383
Query: 794 LQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT 853
L+K P++RLG G +DA+EI FF WQ + + + PPF P + D RYF+ EFT
Sbjct: 384 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 443
Query: 854 GLPPALTPP 862
+TPP
Sbjct: 444 AQMITITPP 452
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 283 bits (723), Expect = 7e-76
Identities = 152/331 (45%), Positives = 205/331 (61%), Gaps = 10/331 (3%)
Query: 555 RLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAV 614
+++DF +LG+G FGKV L +FK T +++AIKALKK VL D++E EKR+L
Sbjct: 376 KIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLA 435
Query: 615 GCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQ 673
HPFL + FQT + FV E++ GGDLM I F +A FY A ++LGLQ
Sbjct: 436 W--EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 493
Query: 674 FLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQ 733
FLH K I+YRDLKLDN+LLD G +KIADFG+CKE + +T+TFCGTP+++APE+L
Sbjct: 494 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLG 553
Query: 734 EAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAP-YPGFLSVQGLEFIQK 792
+ Y +VDWW GVLLYEML+G+ PF G EEE+F I MD P YP +L + + + K
Sbjct: 554 QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI-RMDNPFYPRWLEKEAKDLLVK 612
Query: 793 LLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEF 852
L + PEKRLG +I+ P FR NW+ L + I PPF P + P D F+ EF
Sbjct: 613 LFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 668
Query: 853 TGLPPALTPPAPHSLLTARQQAAFRDFDFVS 883
P L+ A +L+ + Q FR+F F++
Sbjct: 669 LNEKPRLS-FADRALINSMDQNMFRNFSFMN 698
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 273 bits (699), Expect = 4e-73
Identities = 151/377 (40%), Positives = 215/377 (57%), Gaps = 18/377 (4%)
Query: 518 LPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQ 577
+P P+S E+ E R +S LQDF L V+GRG + KVLLV+
Sbjct: 217 IPYNPSSHESLDQVGEEKEAMNTRESGKASSSLG----LQDFDLLRVIGRGSYAKVLLVR 272
Query: 578 FKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACF 637
K T + YA+K +KK+ V ++I+ + EK + E + HPFL+ L +CFQT S F
Sbjct: 273 LKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQA--SNHPFLVGLHSCFQTESRLFF 330
Query: 638 VTEFVPGGDLMMQIHED-VFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQG 696
V E+V GGDLM + PE ARFY A + L L +LHE+ IIYRDLKLDN+LLD++G
Sbjct: 331 VIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG 390
Query: 697 FLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGE 756
+K+ D+G+CKEG+ GD TSTFCGTP ++APE+L E Y +VDWW LGVL++EM+ G
Sbjct: 391 HIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGR 450
Query: 757 CPF---------PGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQ 807
PF +TE+ +F I+ P LSV+ ++ L K P++RLG Q
Sbjct: 451 SPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQ 510
Query: 808 DA-EEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHS 866
+I+ PFFR +W + + + PPF P + G L F+ +FT P LTP
Sbjct: 511 TGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPD-DDD 569
Query: 867 LLTARQQAAFRDFDFVS 883
++ Q+ F F++++
Sbjct: 570 IVRKIDQSEFEGFEYIN 586
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 267 bits (682), Expect = 4e-71
Identities = 144/341 (42%), Positives = 202/341 (59%), Gaps = 12/341 (3%)
Query: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
LQDF + V+GRG + KVLLV+ K + YA+K +KK+ V ++I+ + EK + E
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQA- 124
Query: 616 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHED-VFPEPQARFYVACVVLGLQF 674
+ +PFL+ L +CFQT+S V E+V GGDLM + PE ARFY A + + L F
Sbjct: 125 -SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183
Query: 675 LHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQE 734
LHE+ IIYRDLKLDN+LLDA G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L E
Sbjct: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243
Query: 735 AYTRAVDWWGLGVLLYEMLVGECPF-------PGDTEEEVFDCIVNMDAPYPGFLSVQGL 787
Y +VDWW LGVL++EM+ G PF +TE+ +F I+ P FLSV+
Sbjct: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
Query: 788 EFIQKLLQKCPEKRLGAGEQDA-EEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLR 846
++ L K P++RLG Q +IK FFR+ +W L + PPF P + L
Sbjct: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363
Query: 847 YFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFL 887
F+ +FT P LTP + Q+ F F++++ L
Sbjct: 364 NFDTQFTSEPVQLTPD-DEDAIKRIDQSEFEGFEYINPLLL 403
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 267 bits (682), Expect = 4e-71
Identities = 144/341 (42%), Positives = 202/341 (59%), Gaps = 12/341 (3%)
Query: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
LQDF + V+GRG + KVLLV+ K + YA+K +KK+ V ++I+ + EK + E
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQA- 124
Query: 616 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHED-VFPEPQARFYVACVVLGLQF 674
+ +PFL+ L +CFQT+S V E+V GGDLM + PE ARFY A + + L F
Sbjct: 125 -SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183
Query: 675 LHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQE 734
LHE+ IIYRDLKLDN+LLDA G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L E
Sbjct: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243
Query: 735 AYTRAVDWWGLGVLLYEMLVGECPF-------PGDTEEEVFDCIVNMDAPYPGFLSVQGL 787
Y +VDWW LGVL++EM+ G PF +TE+ +F I+ P FLSV+
Sbjct: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
Query: 788 EFIQKLLQKCPEKRLGAGEQDA-EEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLR 846
++ L K P++RLG Q +IK FFR+ +W L + PPF P + L
Sbjct: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363
Query: 847 YFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFL 887
F+ +FT P LTP + Q+ F F++++ L
Sbjct: 364 NFDTQFTSEPVQLTPD-DEDAIKRIDQSEFEGFEYINPLLL 403
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 267 bits (682), Expect = 4e-71
Identities = 144/341 (42%), Positives = 202/341 (59%), Gaps = 12/341 (3%)
Query: 556 LQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVG 615
LQDF + V+GRG + KVLLV+ K + YA+K +KK+ V ++I+ + EK + E
Sbjct: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQA- 307
Query: 616 CTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHED-VFPEPQARFYVACVVLGLQF 674
+ +PFL+ L +CFQT+S V E+V GGDLM + PE ARFY A + + L F
Sbjct: 308 -SSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 366
Query: 675 LHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQE 734
LHE+ IIYRDLKLDN+LLDA G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L E
Sbjct: 367 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 426
Query: 735 AYTRAVDWWGLGVLLYEMLVGECPF-------PGDTEEEVFDCIVNMDAPYPGFLSVQGL 787
Y +VDWW LGVL++EM+ G PF +TE+ +F I+ P FLSV+
Sbjct: 427 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 486
Query: 788 EFIQKLLQKCPEKRLGAGEQDA-EEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLR 846
++ L K P++RLG Q +IK FFR+ +W L + PPF P + L
Sbjct: 487 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 546
Query: 847 YFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFL 887
F+ +FT P LTP + Q+ F F++++ L
Sbjct: 547 NFDTQFTSEPVQLTPD-DEDAIKRIDQSEFEGFEYINPLLL 586
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 265 bits (676), Expect = 2e-70
Identities = 147/347 (42%), Positives = 201/347 (57%), Gaps = 12/347 (3%)
Query: 509 PPPKPPRLY-LPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGR 567
PP P Y + P +P+ R + +P A PT DF L V+G+
Sbjct: 51 PPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPT-------DFDFLKVIGK 103
Query: 568 GHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLA 627
G++GKVLL + K G +YA+K L+K+ +L + E + E+ +L + HPFL+ L
Sbjct: 104 GNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVL--LKNVRHPFLVGLRY 161
Query: 628 CFQTSSHACFVTEFVPGGDLMMQIH-EDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLK 686
FQT FV ++V GG+L + E F EP+ARFY A V + +LH IIYRDLK
Sbjct: 162 SFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLK 221
Query: 687 LDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLG 746
+N+LLD QG + + DFGLCKEG+ D TSTFCGTPE+LAPEVL +E Y RAVDWW LG
Sbjct: 222 PENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLG 281
Query: 747 VLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGE 806
+LYEML G PF ++++ I++ PG +V + +Q LL K +RLG+ +
Sbjct: 282 AVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGS-K 340
Query: 807 QDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT 853
D EIK FF NW L + + PPF P + GPADL++F+ EFT
Sbjct: 341 ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFT 387
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 261 bits (668), Expect = 2e-69
Identities = 150/352 (42%), Positives = 203/352 (57%), Gaps = 10/352 (2%)
Query: 519 PQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQF 578
PQEP + P + GPS ++P KP DF L V+G+G FGKVLL +
Sbjct: 63 PQEPELMNANPSPPPSPSQQINLGPS--SNPHAKP---SDFHFLKVIGKGSFGKVLLARH 117
Query: 579 KGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFV 638
K +YA+K L+K+ +L + E + + E+ +L + HPFL+ L FQT+ FV
Sbjct: 118 KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNVKHPFLVGLHFSFQTADKLYFV 175
Query: 639 TEFVPGGDLMMQIH-EDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGF 697
+++ GG+L + E F EP+ARFY A + L +LH I+YRDLK +N+LLD+QG
Sbjct: 176 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGH 235
Query: 698 LKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC 757
+ + DFGLCKE I TSTFCGTPE+LAPEVL ++ Y R VDWW LG +LYEML G
Sbjct: 236 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 295
Query: 758 PFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPF 817
PF E++D I+N ++ ++ LLQK KRLGA + D EIK F
Sbjct: 296 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVF 354
Query: 818 FRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLP-PALTPPAPHSLL 868
F NW L+ + I PPF P + GP DLR+F+ EFT P P +P S+L
Sbjct: 355 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVL 406
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 261 bits (668), Expect = 2e-69
Identities = 150/352 (42%), Positives = 203/352 (57%), Gaps = 10/352 (2%)
Query: 519 PQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQF 578
PQEP + P + GPS ++P KP DF L V+G+G FGKVLL +
Sbjct: 77 PQEPELMNANPSPPPSPSQQINLGPS--SNPHAKP---SDFHFLKVIGKGSFGKVLLARH 131
Query: 579 KGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFV 638
K +YA+K L+K+ +L + E + + E+ +L + HPFL+ L FQT+ FV
Sbjct: 132 KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNVKHPFLVGLHFSFQTADKLYFV 189
Query: 639 TEFVPGGDLMMQIH-EDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGF 697
+++ GG+L + E F EP+ARFY A + L +LH I+YRDLK +N+LLD+QG
Sbjct: 190 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGH 249
Query: 698 LKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC 757
+ + DFGLCKE I TSTFCGTPE+LAPEVL ++ Y R VDWW LG +LYEML G
Sbjct: 250 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 309
Query: 758 PFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPF 817
PF E++D I+N ++ ++ LLQK KRLGA + D EIK F
Sbjct: 310 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVF 368
Query: 818 FRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLP-PALTPPAPHSLL 868
F NW L+ + I PPF P + GP DLR+F+ EFT P P +P S+L
Sbjct: 369 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVL 420
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 261 bits (668), Expect = 2e-69
Identities = 150/352 (42%), Positives = 203/352 (57%), Gaps = 10/352 (2%)
Query: 519 PQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQF 578
PQEP + P + GPS ++P KP DF L V+G+G FGKVLL +
Sbjct: 91 PQEPELMNANPSPPPSPSQQINLGPS--SNPHAKP---SDFHFLKVIGKGSFGKVLLARH 145
Query: 579 KGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFV 638
K +YA+K L+K+ +L + E + + E+ +L + HPFL+ L FQT+ FV
Sbjct: 146 KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNVKHPFLVGLHFSFQTADKLYFV 203
Query: 639 TEFVPGGDLMMQIH-EDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGF 697
+++ GG+L + E F EP+ARFY A + L +LH I+YRDLK +N+LLD+QG
Sbjct: 204 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGH 263
Query: 698 LKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC 757
+ + DFGLCKE I TSTFCGTPE+LAPEVL ++ Y R VDWW LG +LYEML G
Sbjct: 264 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 323
Query: 758 PFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPF 817
PF E++D I+N ++ ++ LLQK KRLGA + D EIK F
Sbjct: 324 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVF 382
Query: 818 FRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLP-PALTPPAPHSLL 868
F NW L+ + I PPF P + GP DLR+F+ EFT P P +P S+L
Sbjct: 383 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVL 434
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 261 bits (668), Expect = 2e-69
Identities = 150/352 (42%), Positives = 203/352 (57%), Gaps = 10/352 (2%)
Query: 519 PQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQF 578
PQEP + P + GPS ++P KP DF L V+G+G FGKVLL +
Sbjct: 158 PQEPELMNANPSPPPSPSQQINLGPS--SNPHAKP---SDFHFLKVIGKGSFGKVLLARH 212
Query: 579 KGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFV 638
K +YA+K L+K+ +L + E + + E+ +L + HPFL+ L FQT+ FV
Sbjct: 213 KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNVKHPFLVGLHFSFQTADKLYFV 270
Query: 639 TEFVPGGDLMMQIH-EDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGF 697
+++ GG+L + E F EP+ARFY A + L +LH I+YRDLK +N+LLD+QG
Sbjct: 271 LDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGH 330
Query: 698 LKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGEC 757
+ + DFGLCKE I TSTFCGTPE+LAPEVL ++ Y R VDWW LG +LYEML G
Sbjct: 331 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 390
Query: 758 PFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPF 817
PF E++D I+N ++ ++ LLQK KRLGA + D EIK F
Sbjct: 391 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVF 449
Query: 818 FRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLP-PALTPPAPHSLL 868
F NW L+ + I PPF P + GP DLR+F+ EFT P P +P S+L
Sbjct: 450 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVL 501
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 260 bits (665), Expect = 3e-69
Identities = 140/310 (45%), Positives = 191/310 (61%), Gaps = 7/310 (2%)
Query: 545 PPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESL 604
P A+P +P DF L V+G+G++GKVLL + K G +YA+K L+K+ +L + E +
Sbjct: 24 PSANPNAQPT---DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHI 80
Query: 605 YCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIH-EDVFPEPQARF 663
E+ +L + HPFL+ L FQT FV ++V GG+L + E F EP+ARF
Sbjct: 81 MAERSVL--LKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 138
Query: 664 YVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTP 723
Y A V + +LH IIYRDLK +N+LLD QG + + DFGLCKEG+ D TSTFCGTP
Sbjct: 139 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 198
Query: 724 EFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLS 783
E+LAPEVL +E Y RAVDWW LG +LYEML G PF ++++ I++ PG +
Sbjct: 199 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 258
Query: 784 VQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPA 843
V + +Q LL K +RLG+ + D EIK FF NW L + + PPF P + GPA
Sbjct: 259 VAACDLLQSLLHKDQRQRLGS-KADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPA 317
Query: 844 DLRYFEGEFT 853
DL++F+ EFT
Sbjct: 318 DLKHFDPEFT 327
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 258 bits (658), Expect = 2e-68
Identities = 144/353 (40%), Positives = 211/353 (59%), Gaps = 9/353 (2%)
Query: 521 EPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKG 580
+P+ +E R+ + P +P KP DF L V+G+G FGKVLL + K
Sbjct: 127 DPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPT---DFDFLKVIGKGSFGKVLLAKRKL 183
Query: 581 TGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTE 640
GK+YA+K L+K+ VL+R E + + E+ +L + HPFL+ L FQT+ FV +
Sbjct: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVL--LKNVKHPFLVGLHYSFQTTEKLYFVLD 241
Query: 641 FVPGGDLMMQIH-EDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLK 699
FV GG+L + E FPE +ARFY A + L +LH KI+YRDLK +N+LLD+ G +
Sbjct: 242 FVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVV 301
Query: 700 IADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPF 759
+ DFGLCKEGI D T+TFCGTPE+LAPEV+ ++ Y VDWW LG +LYEML G PF
Sbjct: 302 LTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPF 361
Query: 760 PGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFR 819
E++D I++ +S+ +++LL+K + RLGA ++D EI+ PFF
Sbjct: 362 YCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFE 420
Query: 820 TTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT--GLPPALTPPAPHSLLTA 870
+ +W L+ + I PPF P + GP D+R F+ FT +P ++ + +S++ A
Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNA 473
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,980,685
Number of Sequences: 37866
Number of extensions: 2284899
Number of successful extensions: 18869
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 781
Number of HSP's successfully gapped in prelim test: 766
Number of HSP's that attempted gapping in prelim test: 12403
Number of HSP's gapped (non-prelim): 4873
length of query: 889
length of database: 18,247,518
effective HSP length: 111
effective length of query: 778
effective length of database: 14,044,392
effective search space: 10926536976
effective search space used: 10926536976
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.