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Search of human proteins with 39812133
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
(360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 719 0.0
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens] 625 e-179
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 258 8e-69
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 207 1e-53
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 118 7e-27
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 114 2e-25
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 102 4e-22
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 99 6e-21
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 99 8e-21
gi|30348954 mindbomb homolog 1 [Homo sapiens] 97 2e-20
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 94 1e-19
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 94 1e-19
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 94 1e-19
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 94 2e-19
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 94 2e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 94 2e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 94 2e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 94 2e-19
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 93 4e-19
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 92 6e-19
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 92 7e-19
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 91 1e-18
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 91 2e-18
gi|17864094 feminization 1 homolog a [Homo sapiens] 89 8e-18
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 88 1e-17
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 86 4e-17
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 86 4e-17
gi|34304381 inversin isoform a [Homo sapiens] 86 5e-17
gi|34304379 inversin isoform b [Homo sapiens] 86 5e-17
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 86 5e-17
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 719 bits (1857), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG 60
MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG
Sbjct: 1 MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG 60
Query: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK
Sbjct: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
Query: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF
Sbjct: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
Query: 181 RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT
Sbjct: 181 RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
Query: 241 NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLL 300
NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLL
Sbjct: 241 NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLL 300
Query: 301 LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 360
LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
Sbjct: 301 LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 360
>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
Length = 327
Score = 625 bits (1613), Expect = e-179
Identities = 322/360 (89%), Positives = 322/360 (89%), Gaps = 33/360 (9%)
Query: 1 MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG 60
MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG
Sbjct: 1 MAKAPSWAGVGALAYKAPEALWPAEAVMDGTMEDSEAVQRATALIEQRLAQEEENEKLRG 60
Query: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK
Sbjct: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
Query: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF
Sbjct: 121 KRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQF 180
Query: 181 RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT
Sbjct: 181 RRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
Query: 241 NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLL 300
NVRDK T LH AVR LNRYKIIKLLL
Sbjct: 241 NVRDKEGDTALHDAVR---------------------------------LNRYKIIKLLL 267
Query: 301 LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 360
LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ
Sbjct: 268 LHGADMMTKNLAGKTPTDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 327
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 258 bits (658), Expect = 8e-69
Identities = 125/237 (52%), Positives = 175/237 (73%), Gaps = 3/237 (1%)
Query: 92 QERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEET 151
+ ++K L+ R ++ ++ ++ +I+L+K++K +K PEPE IT PVD T
Sbjct: 67 EAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKE---PEPEIITEPVDVPT 123
Query: 152 FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211
FLKAA+E K+ V+EKFL+D + D CD+++RTALHRA LEGH+ I+EKL++ GA ++F+D
Sbjct: 124 FLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD 183
Query: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL 271
L+ TA+HWA RGG+L+V+KLL + GA + RDKLLST LHVAVRTG E EH ++
Sbjct: 184 MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
Query: 272 EINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTR 328
++NA+DREGDT LHDAVRLNRYK+I+LL+++GAD+ KN AGKTP DLV WQ T+
Sbjct: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTK 300
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 207 bits (527), Expect = 1e-53
Identities = 111/246 (45%), Positives = 153/246 (62%), Gaps = 4/246 (1%)
Query: 87 QKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGP 146
+K K ER T +L ++ ++NL++ RKKR + + P+ + P
Sbjct: 54 EKKKKLERFNSTRFNLD----NLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEP 109
Query: 147 VDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
V E FLKAA E + +I+K+L DGG + D+ RTALH A L+GH +++ KLL GAT
Sbjct: 110 VGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGAT 169
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
VD +D LD T + WACRGGHL ++K L + GA N RDK+ STPLHVAVRT + +EH
Sbjct: 170 VDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHL 229
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQAD 326
+ G +NA+D+EGDTALH+AVR YK +KLLLL+GA++ +N A TP L + WQ
Sbjct: 230 IECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRG 289
Query: 327 TRHALE 332
R AL+
Sbjct: 290 IREALQ 295
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 118 bits (296), Expect = 7e-27
Identities = 65/162 (40%), Positives = 96/162 (59%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +K E + S + D+ RTALH A+L GH+E++ LL GA ++ D+ D
Sbjct: 89 AAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKD 148
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
A+HWA GHL+VV LL +HGA+ +DK TPLH A GQ+ +V+H L+LG+EI+
Sbjct: 149 RRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID 208
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ G+TALH A + ++ L+ +GA++ N G TP
Sbjct: 209 EINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTP 250
Score = 89.4 bits (220), Expect = 5e-18
Identities = 52/132 (39%), Positives = 72/132 (54%)
Query: 175 DTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQ 234
+T D +RT LH A+ G EI+E L+ +GA V+ +D + T +H A E V++L
Sbjct: 10 NTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLI 69
Query: 235 SHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYK 294
H AD N RDK TPLHVA V+ E + L +N DR G TALH A +
Sbjct: 70 KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVE 129
Query: 295 IIKLLLLHGADM 306
++ LLL GA++
Sbjct: 130 MVNLLLAKGANI 141
Score = 87.4 bits (215), Expect = 2e-17
Identities = 52/175 (29%), Positives = 93/175 (53%), Gaps = 1/175 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G ++++ LA G + + D+ R ALH A+ GH++++ L+++GA V +D+
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A G + VVK L + G + + + +T LH+A GQ +V + G +N
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241
Query: 275 ARDREGDTALHDAVRLNRYKI-IKLLLLHGADMMTKNLAGKTPTDLVQLWQADTR 328
+ G T LH A + ++LL+ +GAD+ ++ GK+P + + TR
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
Score = 83.6 bits (205), Expect = 3e-16
Identities = 48/133 (36%), Positives = 64/133 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +I G C LH A+L H + KLL +G +D D+
Sbjct: 321 AARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFG 380
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A GG++E +KLLQS GAD + +DK TPLH A +E ++ G +N
Sbjct: 381 RTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN 440
Query: 275 ARDREGDTALHDA 287
D G TALH A
Sbjct: 441 ETDDWGRTALHYA 453
Score = 78.2 bits (191), Expect = 1e-14
Identities = 51/169 (30%), Positives = 83/169 (49%), Gaps = 1/169 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G++ V++ L G D + + TALH A G ++ +L+D GA V+ +
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247
Query: 215 CTAMHWACRGGHLEV-VKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEI 273
T +H+A H + ++LL ++GAD N++ K +PLH+ G+ + + G EI
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI 307
Query: 274 NARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQL 322
+ D++G+T LH A R +I L GAD + P L L
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
Score = 77.8 bits (190), Expect = 1e-14
Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 1/165 (0%)
Query: 152 FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211
F A+ G + +E + +G + + ++ LH ++ G + L+ NG +D D
Sbjct: 253 FAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVD 311
Query: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL 271
+ T +H A R GH ++ L++ GADT PLH+A + LS G
Sbjct: 312 KDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371
Query: 272 EINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
EI+ D+ G T LH A + IKLL GAD K+ G+TP
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
Score = 65.9 bits (159), Expect = 6e-11
Identities = 52/169 (30%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQF-RRTALHRASLEGH---MEILEKLLDNGATVDFQ 210
AA +G + +E + G S D +RT LH + + GH + +L ++ DN VD +
Sbjct: 582 AAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVK 641
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
D T + A GH++ V LL A+ + D L T LH + TG E V+ L
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLL---LHGADMMTKNLAGKTP 316
+ I +D G T LH A + LL L D K+ G TP
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750
Score = 65.5 bits (158), Expect = 7e-11
Identities = 45/160 (28%), Positives = 72/160 (45%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
AV G+ + + +GG D D+ T LH A+ GH ++ L +GA
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM 348
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINA 275
+H A H + + L S G + + DK T LH A G VE ++ S G + +
Sbjct: 349 FPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHK 408
Query: 276 RDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
+D+ G T LH A + I+ L+ GA++ + G+T
Sbjct: 409 KDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRT 448
Score = 62.0 bits (149), Expect = 8e-10
Identities = 49/167 (29%), Positives = 78/167 (46%), Gaps = 6/167 (3%)
Query: 155 AAVEGKMKVIEKFL--ADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
AA G + +E L + G ++ ++ LH A+ GH + LE LL + +D +D
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLS-TPLHVAVRTGQVEIVEHFLSLG- 270
TA+ A GH E V+ L + GA V+D + TPLH +V G + L +
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIAD 633
Query: 271 --LEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
++ +D +G T L AV + LLL A++ T ++ G T
Sbjct: 634 NPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT 680
Score = 61.2 bits (147), Expect = 1e-09
Identities = 50/193 (25%), Positives = 81/193 (41%), Gaps = 28/193 (14%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ K L+ G DT D+F RT LH A+ G++E ++ L +GA +D+
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQV-------------- 260
T +H+A H ++ L + GA+ N D T LH A +
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473
Query: 261 ------EIVEHFLSLGLEI--------NARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
E+ E +L LE + RD+EG ++H A + ++LLL
Sbjct: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533
Query: 307 MTKNLAGKTPTDL 319
++ +G T + L
Sbjct: 534 FEESDSGATKSPL 546
Score = 58.9 bits (141), Expect = 7e-09
Identities = 44/137 (32%), Positives = 61/137 (44%), Gaps = 4/137 (2%)
Query: 168 LADGGSA-DTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGH 226
+AD A D D +T L A GH++ + LL+ A VD D L CTA+H GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 227 LEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL---EINARDREGDTA 283
E V++L +D TPLH A G + L + L + +D +G T
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750
Query: 284 LHDAVRLNRYKIIKLLL 300
LH A I++LL
Sbjct: 751 LHWACYNGNENCIEVLL 767
Score = 55.5 bits (132), Expect = 7e-08
Identities = 52/216 (24%), Positives = 84/216 (38%), Gaps = 39/216 (18%)
Query: 138 PEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEIL 197
PE ++ + + A G + + L + DT D TALHR + GH E +
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHL----EVVKLLQSHGADTNVRDKLLSTPLHV 253
+ LL+ ++ +D T +H+A GH E++++ S D +D TPLH
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSE-EDCCFKDNQGYTPLHW 753
Query: 254 AVRTGQVEIVEHFLS------------------------------LGLE----INARDRE 279
A G +E L LG ++ RD +
Sbjct: 754 ACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
Query: 280 GDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
G T L A + + ++LLL H A + + +GKT
Sbjct: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKT 849
Score = 55.1 bits (131), Expect = 1e-07
Identities = 49/193 (25%), Positives = 82/193 (42%), Gaps = 31/193 (16%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRAS--------------------LEGHM 194
AA IE + G + + D + RTALH A+ LE
Sbjct: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAR 479
Query: 195 EILEK--------LLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLL--QSHGADTNVRD 244
E+ EK LL N A +D+ ++H+A GH + ++LL +++
Sbjct: 480 ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539
Query: 245 KLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGA 304
+PLH+A G + +E L ++++ RD +G TAL A + ++ L+ GA
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA 599
Query: 305 DMMTK-NLAGKTP 316
+ K N+ +TP
Sbjct: 600 SIFVKDNVTKRTP 612
Score = 53.1 bits (126), Expect = 4e-07
Identities = 28/78 (35%), Positives = 41/78 (52%)
Query: 239 DTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKL 298
D N D TPLHVA G EI+E + G +NA+D T LH AV + +++
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 299 LLLHGADMMTKNLAGKTP 316
L+ H AD+ ++ +TP
Sbjct: 68 LIKHSADVNARDKNWQTP 85
Score = 53.1 bits (126), Expect = 4e-07
Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 3/110 (2%)
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEH 265
T+D + R T +H A G E+++LL GA N +D + TPLH AV + E V+
Sbjct: 11 TLDSEKR---TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
+ ++NARD+ T LH A K ++++ + + + G+T
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRT 117
Score = 48.9 bits (115), Expect = 7e-06
Identities = 32/82 (39%), Positives = 42/82 (51%), Gaps = 1/82 (1%)
Query: 178 DQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLL-QSH 236
D RT L A+ H+E L+ LL + A V+ D TA+ A G V +L S
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 237 GADTNVRDKLLSTPLHVAVRTG 258
AD V+DK L+TPLH+A G
Sbjct: 871 QADLTVKDKDLNTPLHLACSKG 892
Score = 41.2 bits (95), Expect = 0.001
Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 3/121 (2%)
Query: 183 TALHRASLEGHMEILEKLLD--NGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADT 240
T LH A + H LL + + V +D T + A H+E ++LL H A
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
Query: 241 NVRDKLLSTPLHVAVRTGQVEIVEHFL-SLGLEINARDREGDTALHDAVRLNRYKIIKLL 299
N D T L +A GQ V+ + S ++ +D++ +T LH A K L+
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900
Query: 300 L 300
L
Sbjct: 901 L 901
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 114 bits (284), Expect = 2e-25
Identities = 62/162 (38%), Positives = 93/162 (57%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +K E + + + D+ RTALH A+ GH E+++ LL GA ++ D+ D
Sbjct: 114 AAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD 173
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
A+HWA GH+EVVKLL SHGA+ +DK TPLH A +G + +V++ L LG+++N
Sbjct: 174 RRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN 233
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ G+T LH A + ++ L+ GA + KN G TP
Sbjct: 234 EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTP 275
Score = 89.0 bits (219), Expect = 6e-18
Identities = 54/159 (33%), Positives = 80/159 (50%)
Query: 148 DEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV 207
D+ + ++A G + + + D +RT LH A+ G EI+E L+ +GA V
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 208 DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFL 267
+ +D T +H A E V++L H AD N RDK TPLH+A V+ E +
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 268 SLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
L +N DR G TALH A +++KLLL GA++
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
Score = 84.7 bits (208), Expect = 1e-16
Identities = 52/163 (31%), Positives = 79/163 (48%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
+A + ++ L + D+ +T LH A+ ++ E L+ + V+ DR
Sbjct: 80 RAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA 139
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEI 273
TA+H A GH E+VKLL S GA+ N DK +H A G +E+V+ +S G E+
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199
Query: 274 NARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+D++ T LH A ++K LL G DM N G TP
Sbjct: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP 242
Score = 79.3 bits (194), Expect = 5e-15
Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 1/169 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V++ L G + + + T LH A G ++ +L+D GA V+ ++
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKG 272
Query: 215 CTAMHWACRGGHLEV-VKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEI 273
T +H+A H + ++LL +GAD N++ K TPLH+ G+ + + G I
Sbjct: 273 FTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI 332
Query: 274 NARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQL 322
+ D+ G+T LH A R +I L+ GAD + + G P L L
Sbjct: 333 DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAAL 381
Score = 79.0 bits (193), Expect = 6e-15
Identities = 50/165 (30%), Positives = 80/165 (48%), Gaps = 1/165 (0%)
Query: 152 FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211
F A+ G + +E + +G + + +T LH +L G + ++ +GA +D +D
Sbjct: 278 FAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCED 336
Query: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL 271
+ T +H A R GH ++ L + GADT R PLH+A +G + LS G
Sbjct: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
Query: 272 EINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+I+ D G T LH A + + LLL GAD K+ G++P
Sbjct: 397 DIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
Score = 73.2 bits (178), Expect = 3e-13
Identities = 60/227 (26%), Positives = 91/227 (40%), Gaps = 42/227 (18%)
Query: 130 LAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRAS 189
L + P +I + + + + G + L G + D D++ RTALHR +
Sbjct: 635 LLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGA 694
Query: 190 LEGHMEILEKLLDNGATVDFQD---------------------------RLDC------- 215
+ GH E ++ LL +GA +D +D
Sbjct: 695 VTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADN 754
Query: 216 ---TAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAV---RTGQVEIVEHFLSL 269
TA+HWAC GH V+LL S PLH AV G E++ L
Sbjct: 755 HGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFS-PLHCAVINDNEGAAEMLIDTLGA 813
Query: 270 GLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ +NA D +G T LH A + + ++LLL H A + + + GKTP
Sbjct: 814 SI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTP 859
Score = 67.8 bits (164), Expect = 1e-11
Identities = 38/103 (36%), Positives = 52/103 (50%)
Query: 185 LHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRD 244
LH A+L G + KLL +G +D D T +H A GG+LE + LL + GAD N +D
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
Query: 245 KLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDA 287
K +PLH A + + + G +N D G T LH A
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 67.8 bits (164), Expect = 1e-11
Identities = 47/167 (28%), Positives = 78/167 (46%), Gaps = 13/167 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G K L+ G DT D F RT LH A+ G++E L LL+ GA + +D+
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTG-QVEIVEHFLSLGLEI 273
+ +H+A + + + L GA N D+ TPLH A + + +E+ L
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498
Query: 274 NARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV 320
RD++G A+H + +G + + +A +TP D++
Sbjct: 499 GIRDKQGYNAVHYSA------------AYGHRLCLQLIASETPLDVL 533
Score = 67.0 bits (162), Expect = 2e-11
Identities = 47/156 (30%), Positives = 70/156 (44%), Gaps = 4/156 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQF-RRTALHRASLEGHMEILEKLLDNGA---TVDFQ 210
AA +G ++ ++ + G S D +RT +H A+ GH E L L+ N VD Q
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
D T + + GH + V L + GA+ + +DK T LH TG E V+ L G
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
+ RD G T +H + ++ LL A M
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASM 745
Score = 65.9 bits (159), Expect = 6e-11
Identities = 46/153 (30%), Positives = 70/153 (45%), Gaps = 7/153 (4%)
Query: 155 AAVEGKMKVIEKFLADG---GSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211
AA G + + + + + D D +T L + L GH + + LL+ GA VD +D
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683
Query: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL 271
+ TA+H GH E V L HGA +RD TP+H++ G + ++ L
Sbjct: 684 KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743
Query: 272 EINAR----DREGDTALHDAVRLNRYKIIKLLL 300
++A D G TALH A ++LLL
Sbjct: 744 SMDANPATADNHGYTALHWACYNGHETCVELLL 776
Score = 61.2 bits (147), Expect = 1e-09
Identities = 41/132 (31%), Positives = 64/132 (48%)
Query: 184 ALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVR 243
+L +A G + + L+ V+FQD T +H A G E+++LL GA N +
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 244 DKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHG 303
D TPLH AV + E V+ L ++NARD+ T LH A K + L+
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 304 ADMMTKNLAGKT 315
+++ + AG+T
Sbjct: 131 SNVNVSDRAGRT 142
Score = 61.2 bits (147), Expect = 1e-09
Identities = 52/193 (26%), Positives = 79/193 (40%), Gaps = 38/193 (19%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ--- 210
+ AV G + ++ L G D RT +H ++ GH+ +L LL + A++D
Sbjct: 692 RGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPAT 751
Query: 211 -DRLDCTAMHWACRGGHLEVVKLL-----------------------QSHGA-----DT- 240
D TA+HWAC GH V+LL + GA DT
Sbjct: 752 ADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTL 811
Query: 241 -----NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
N D TPLH A T VE ++ LS ++N+ D G T L A +
Sbjct: 812 GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNT 871
Query: 296 IKLLLLHGADMMT 308
+++L+ + +T
Sbjct: 872 VEMLVSSASAELT 884
Score = 56.2 bits (134), Expect = 4e-08
Identities = 45/144 (31%), Positives = 67/144 (46%), Gaps = 6/144 (4%)
Query: 178 DQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLL-QSH 236
D RT LH A+ H+E L+ LL + A V+ D T + A G V++L S
Sbjct: 820 DSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 879
Query: 237 GADTNVRDKLLSTPLHVAV----RTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNR 292
A+ ++D +T LH+A T + I+E L INA + T LH A R
Sbjct: 880 SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL-INATNAALQTPLHVAARNGL 938
Query: 293 YKIIKLLLLHGADMMTKNLAGKTP 316
+++ LL GA ++ + G TP
Sbjct: 939 TMVVQELLGKGASVLAVDENGYTP 962
Score = 53.9 bits (128), Expect = 2e-07
Identities = 31/92 (33%), Positives = 47/92 (51%)
Query: 225 GHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTAL 284
G + V+ L D N +D TPLH A G EI+E + G +NA+D + T L
Sbjct: 19 GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL 78
Query: 285 HDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
H AV + +++LL H AD+ ++ +TP
Sbjct: 79 HRAVASCSEEAVQVLLKHSADVNARDKNWQTP 110
Score = 50.4 bits (119), Expect = 2e-06
Identities = 35/104 (33%), Positives = 49/104 (47%), Gaps = 3/104 (2%)
Query: 185 LHRASLEGHMEILEKLLDN--GATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
LH A + + E L+D + V+ D T +H A H+E ++LL SH A N
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFL-SLGLEINARDREGDTALH 285
D TPL +A GQ VE + S E+ +D +TALH
Sbjct: 852 VDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895
Score = 47.8 bits (112), Expect = 2e-05
Identities = 42/176 (23%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASL-EGHMEILEKLLDNGATVDFQDRL 213
AA + + + G S + D+ T LH A+ + + LE LL N A +D+
Sbjct: 445 AAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQ 504
Query: 214 DCTAMHWACRGGH---LEVVK-------LLQSHGAD--TNVRDKLLSTPLHVAVRTGQVE 261
A+H++ GH L+++ L+++ G D ++ ++ +PLH+A G +
Sbjct: 505 GYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ 564
Query: 262 IVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKN-LAGKTP 316
+E + L+++ R+ G T L A + + +L+ GA ++ K+ + +TP
Sbjct: 565 ALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTP 620
Score = 41.6 bits (96), Expect = 0.001
Identities = 35/152 (23%), Positives = 65/152 (42%), Gaps = 13/152 (8%)
Query: 162 KVIEKFLADGGSADTCDQFRRTALHRASLEGH------------MEILEKLLDNGATVDF 209
K +E L + + D+ A+H ++ GH +++L + D
Sbjct: 486 KCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDS 545
Query: 210 QDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSL 269
+R + +H A GH + +++L D +VR+ TPL +A G VE V+ ++
Sbjct: 546 DNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605
Query: 270 GLEINARDR-EGDTALHDAVRLNRYKIIKLLL 300
G I +D T +H A + ++LL+
Sbjct: 606 GASILVKDYILKRTPIHAAATNGHSECLRLLI 637
Score = 33.9 bits (76), Expect = 0.23
Identities = 21/63 (33%), Positives = 32/63 (50%)
Query: 254 AVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 313
A+ G + V + ++N +D E T LH A L +II+LL+L GA + K+
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 314 KTP 316
TP
Sbjct: 75 LTP 77
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 102 bits (255), Expect = 4e-22
Identities = 65/184 (35%), Positives = 98/184 (53%), Gaps = 6/184 (3%)
Query: 148 DEET-FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D+ T ++AA ++ ++ + G D D T LH A+ +GH E+++ LL NG
Sbjct: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
Query: 207 -VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEH 265
V+ QD T M WA H+++VKLL S G+D N+RD + LH A +G V+I E
Sbjct: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEI 924
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV----Q 321
L+ +++A + GD+ LH A R NRY + L L +D+ KN G+TP Q
Sbjct: 925 LLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQ 984
Query: 322 LWQA 325
+W A
Sbjct: 985 VWSA 988
Score = 74.7 bits (182), Expect = 1e-13
Identities = 50/155 (32%), Positives = 81/155 (52%), Gaps = 3/155 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTC--DQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
+A +G+++ + L DG + Q +R+ LH A+ GH++I L+ GA +D
Sbjct: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG-L 271
T + A HLE VK L GA + +D ST LH+A + G E+V++ LS G +
Sbjct: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864
Query: 272 EINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
++N +D G T + A ++KLLL G+D+
Sbjct: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDI 899
Score = 44.3 bits (103), Expect = 2e-04
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 218 MHWACRGGHLEVVKLLQSHGADTNVRDKLLS--TPLHVAVRTGQVEIVEHFLSLGLEINA 275
++++ R G L+ V L+ G D N + + + +PLH A G V+I + G I+
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
Query: 276 RDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
+ T L +A N + +K L+ GA + K+ G T
Sbjct: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGST 841
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 99.0 bits (245), Expect = 6e-21
Identities = 56/171 (32%), Positives = 92/171 (53%)
Query: 148 DEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV 207
D+ +A V G ++I + +G + D D+ TALH AS G + + L+ GA V
Sbjct: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
Query: 208 DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFL 267
+++ TA+H AC+ H + ++L G+ ++++ T LHVA R + I+ L
Sbjct: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
Query: 268 SLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTD 318
+ ++ +++ GDTALH A LN K+ K+LL GAD N AG+TP +
Sbjct: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
Score = 92.0 bits (227), Expect = 7e-19
Identities = 57/161 (35%), Positives = 83/161 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +G + V++ L G D D +TALHRA++ G+ EI+ L+ G +D QD+
Sbjct: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+H A G + KLL GA+ ++K +T LH+A + + L G +
Sbjct: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
++ GDT LH A R N II+LLL + KN AG T
Sbjct: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDT 209
Score = 76.6 bits (187), Expect = 3e-14
Identities = 53/166 (31%), Positives = 89/166 (53%), Gaps = 1/166 (0%)
Query: 150 ETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDF 209
E L AA +G+ + + + L + G+ + RT LH A+ +GH+ +++ LL G +D
Sbjct: 12 ERLLVAAYKGQTENVVQ-LINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDV 70
Query: 210 QDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSL 269
QD D TA+H A G+ E++ L G + +DK +T LH A G + + +
Sbjct: 71 QDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKA 130
Query: 270 GLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
G + A+++ G+TALH A + + + ++LLL G+ KN AG T
Sbjct: 131 GANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT 176
Score = 73.6 bits (179), Expect = 3e-13
Identities = 46/132 (34%), Positives = 71/132 (53%), Gaps = 1/132 (0%)
Query: 188 ASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLL 247
A+ +G E + +L++ GA V T +H A GHL VV++L G D +V+D
Sbjct: 17 AAYKGQTENVVQLINKGARVAVTKH-GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
Query: 248 STPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMM 307
T LH A G EI+ + G ++ +D++G+TALH+A + KLL+ GA+++
Sbjct: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
Query: 308 TKNLAGKTPTDL 319
KN AG T L
Sbjct: 136 AKNKAGNTALHL 147
Score = 45.8 bits (107), Expect = 6e-05
Identities = 29/87 (33%), Positives = 42/87 (48%)
Query: 168 LADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHL 227
L G AD + T LH A+ H+ I+ LL +V +++ TA+H A H
Sbjct: 161 LLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHK 220
Query: 228 EVVKLLQSHGADTNVRDKLLSTPLHVA 254
+V K+L GADT + + TPL A
Sbjct: 221 KVAKILLEAGADTTIVNNAGQTPLETA 247
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 98.6 bits (244), Expect = 8e-21
Identities = 59/162 (36%), Positives = 89/162 (54%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA K E S + D+ R+ALH A GH+E + LL+ GA+++ D+ +
Sbjct: 114 AAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE 173
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
+HWA GHLEV+KLL + GAD +D+ LH A +GQ+E+V++ L +G EI+
Sbjct: 174 RQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID 233
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ G+TALH A L + + L+ GA++ N G TP
Sbjct: 234 EPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTP 275
Score = 96.7 bits (239), Expect = 3e-20
Identities = 57/159 (35%), Positives = 83/159 (52%)
Query: 148 DEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV 207
D+ ++A ++ + L+ + + DQ RRT LH A+ G + IL+ LL +GA V
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 208 DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFL 267
+ +D L T +H A + +V+ LL +H AD N RDKL TPLHVA + E
Sbjct: 68 NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127
Query: 268 SLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
L +N DR G +ALH AV + + LLL GA +
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL 166
Score = 89.7 bits (221), Expect = 4e-18
Identities = 55/175 (31%), Positives = 90/175 (51%), Gaps = 1/175 (0%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A G ++ + L G S + CD+ R LH A+ GH+E+L+ L+ GA + +DR
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
+H A G +EVVK L GA+ + + +T LH+A GQ + ++ G +N
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
Query: 275 ARDREGDTALH-DAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTR 328
+ +G T LH AV N ++LL+ +GAD+ ++ GK+P + + TR
Sbjct: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTR 321
Score = 89.0 bits (219), Expect = 6e-18
Identities = 61/197 (30%), Positives = 94/197 (47%), Gaps = 4/197 (2%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
+AA KV+ LA + D+ +T LH A+ + E L ++++ DR
Sbjct: 80 RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEI 273
+A+H A GHLE V LL + GA NV DK PLH A G +E+++ ++ G ++
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
Query: 274 NARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEH 333
+DR+G LH A + +++K LL GA++ N G T + + A+E
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH-IACYLGQDAVAIEL 258
Query: 334 PEPGAEHNGLEGPNDSG 350
GA N PND G
Sbjct: 259 VNAGANVN---QPNDKG 272
Score = 78.2 bits (191), Expect = 1e-14
Identities = 52/171 (30%), Positives = 82/171 (47%), Gaps = 18/171 (10%)
Query: 164 IEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACR 223
+E + +G + + ++ LH A++ G + L+ NG+ +D D+ T +H A R
Sbjct: 289 LELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAAR 348
Query: 224 GGHLEVVKLLQSHGADTNVRDKLLSTPLHVAV------------RTGQVEIV------EH 265
GH ++ L ++GADT R PLH+AV +GQ+ + EH
Sbjct: 349 YGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEH 408
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
LS G +IN D G T LH A + + LLL GAD+ ++ G+TP
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTP 459
Score = 74.7 bits (182), Expect = 1e-13
Identities = 53/171 (30%), Positives = 85/171 (49%), Gaps = 3/171 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G+++V++ L G D + F TALH A G + +L++ GA V+ +
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
Query: 215 CTAMHWAC--RGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
T +H A G L ++LL ++GAD N + K +PLH+A G+ + + G E
Sbjct: 273 FTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSE 331
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLW 323
I+ D+ G+T LH A R +I L+ +GAD + + P L L+
Sbjct: 332 IDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLF 382
Score = 74.3 bits (181), Expect = 2e-13
Identities = 81/304 (26%), Positives = 124/304 (40%), Gaps = 58/304 (19%)
Query: 61 DARQKLPMDLLVLEDEKHHGAQSAALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRK 120
+A + L L+ L+ H G + L +G E++ G LI+ RK
Sbjct: 599 EALKTLAETLVNLDVRDHKGRTALFLATERGSTECV--------EVLTAHGASALIKERK 650
Query: 121 KRKQKKRDALAASHEPP-------PEPEEITGPVD---EETFLKAAVEGKMKVIEKFLAD 170
++ A A+ H E +IT +D + + A + G + + L
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
Query: 171 GGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV---DFQDR--------------- 212
G +AD D RTALHR ++ G + L LLD+ A V DF+ R
Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770
Query: 213 ------------LDC-------TAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHV 253
LD + MHWA GH + ++LL H + + TPLH
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF-TPLHC 829
Query: 254 AVRTGQVEIVEHFL-SLGLEI-NARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNL 311
AV Q E L +LG +I N+RD +G T LH A + +++LL H A++ +
Sbjct: 830 AVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDH 889
Query: 312 AGKT 315
G+T
Sbjct: 890 TGRT 893
Score = 68.2 bits (165), Expect = 1e-11
Identities = 55/183 (30%), Positives = 82/183 (44%), Gaps = 4/183 (2%)
Query: 141 EEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKL 200
E++ + AA G + ++ + D D RTAL A+ G E +E L
Sbjct: 578 EDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVL 637
Query: 201 LDNGATVDFQDRL-DCTAMHWACRGGHLEVVKLLQSHG--AD-TNVRDKLLSTPLHVAVR 256
+GA+ ++R T +H A GH + + LL G AD T+V D TPL +A+
Sbjct: 638 TAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIM 697
Query: 257 TGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G V+ V L G +A D G TALH + LL H A ++ ++ G+TP
Sbjct: 698 NGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTP 757
Query: 317 TDL 319
L
Sbjct: 758 IHL 760
Score = 67.8 bits (164), Expect = 1e-11
Identities = 51/180 (28%), Positives = 74/180 (41%), Gaps = 18/180 (10%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ + + +G D D+F T LH A+ GH ++ L+ NGA + D
Sbjct: 313 AAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHD 372
Query: 215 CTAMHWACRGGHLEVVKLLQSHGA------------------DTNVRDKLLSTPLHVAVR 256
+H A G + + L S G D N D L T LH A
Sbjct: 373 MFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAAS 432
Query: 257 TGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G VE + LS G ++ RD+ G T LH A Y+ L+ GA + + G +P
Sbjct: 433 GGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSP 492
Score = 61.6 bits (148), Expect = 1e-09
Identities = 44/151 (29%), Positives = 69/151 (45%), Gaps = 5/151 (3%)
Query: 165 EKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRG 224
E L+ G +T D RT LH A+ G++E L LL +GA + +D+ T +H+A
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 225 GHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTAL 284
G + L + GA N D +PLH A + E ++ D E D L
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTP-----SSHDAEEDEPL 521
Query: 285 HDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
++ R + ++ LL +GAD ++ G T
Sbjct: 522 KESRRKEAFFCLEFLLDNGADPSLRDRQGYT 552
Score = 57.0 bits (136), Expect = 3e-08
Identities = 33/90 (36%), Positives = 47/90 (52%)
Query: 227 LEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHD 286
+E V+ L S + NV D+ TPLH A G V I++ L G +NA+D T LH
Sbjct: 21 VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHR 80
Query: 287 AVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A K++ LLL H AD+ ++ +TP
Sbjct: 81 AAASRNEKVLGLLLAHSADVNARDKLWQTP 110
Score = 57.0 bits (136), Expect = 3e-08
Identities = 46/140 (32%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 182 RTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHG-ADT 240
RT LH A+ ++ L LL + A V+ D TA+ A G V+ L G AD
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADL 918
Query: 241 NVRDKLLSTPLHVAVRTGQ----VEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKII 296
V D+ +T LH+A G + I+ LGL INA + LH A R ++
Sbjct: 919 TVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAARNGLASVV 977
Query: 297 KLLLLHGADMMTKNLAGKTP 316
+ LL HGA ++ + G TP
Sbjct: 978 QALLSHGATVLAVDEEGHTP 997
Score = 56.6 bits (135), Expect = 3e-08
Identities = 41/132 (31%), Positives = 57/132 (43%), Gaps = 4/132 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNG-ATVDFQDRL 213
AA + + L + D RTAL A+ G +E LL G A + D
Sbjct: 865 AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADT---NVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
TA+H AC GH + ++ + D N + L PLH+A R G +V+ LS G
Sbjct: 925 KNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHG 984
Query: 271 LEINARDREGDT 282
+ A D EG T
Sbjct: 985 ATVLAVDEEGHT 996
Score = 52.8 bits (125), Expect = 5e-07
Identities = 40/146 (27%), Positives = 66/146 (45%), Gaps = 5/146 (3%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G ++ + L+ G D+F RT LH A+ G + L+ GA V+ D
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
C+ +H+A + + + H ++ D PL + R +E L G + +
Sbjct: 490 CSPLHYAAAS---DTYRRAEPHTPSSH--DAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLL 300
RDR+G TA+H A + ++LLL
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLL 570
Score = 39.3 bits (90), Expect = 0.006
Identities = 25/67 (37%), Positives = 35/67 (52%)
Query: 250 PLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTK 309
PL A+ + VE V LS IN D+E T LH A + I++LLL+ GA++ K
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 310 NLAGKTP 316
+ TP
Sbjct: 71 DTLWLTP 77
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 97.4 bits (241), Expect = 2e-20
Identities = 60/170 (35%), Positives = 89/170 (52%), Gaps = 1/170 (0%)
Query: 144 TGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDN 203
+G ++EE +KAA G + +E L TA+ AS GH++IL+ LL
Sbjct: 428 SGDLNEE-LVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQ 486
Query: 204 GATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIV 263
V+ +D+ A+H A G V+++L AD N R+K TPLH+AV G +++V
Sbjct: 487 NVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVV 546
Query: 264 EHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 313
+ L G + +D EGDT LHDA+ R I+ +LL GAD+ N G
Sbjct: 547 KTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNG 596
Score = 66.6 bits (161), Expect = 3e-11
Identities = 47/146 (32%), Positives = 75/146 (51%), Gaps = 9/146 (6%)
Query: 183 TALHRASLEGHMEILEKLLDNG-ATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTN 241
TALH A+L H+E+ E L+ G A +D Q+ TA+H A H ++V+LL GA +
Sbjct: 634 TALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLD 693
Query: 242 VRDKLLSTPLHVAVR---TGQVEIVEHFLSLGLEINARDREGDTAL-----HDAVRLNRY 293
++DK TPLH A+R Q+ ++ +G A + +T + A + +
Sbjct: 694 IQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAA 753
Query: 294 KIIKLLLLHGADMMTKNLAGKTPTDL 319
I L +GAD+ +N G++P DL
Sbjct: 754 SIACFLAANGADLSIRNKKGQSPLDL 779
Score = 61.6 bits (148), Expect = 1e-09
Identities = 46/145 (31%), Positives = 73/145 (50%), Gaps = 5/145 (3%)
Query: 150 ETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGH---MEILEKLLDNGA 205
+T L A+ K I L + G+ T ALH A+L G+ M +L L
Sbjct: 564 DTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPW 623
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHG-ADTNVRDKLLSTPLHVAVRTGQVEIVE 264
VD + TA+H A H+EV +LL G A+ ++++ T LH+AV +IV
Sbjct: 624 IVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVR 683
Query: 265 HFLSLGLEINARDREGDTALHDAVR 289
+ G +++ +D++GDT LH+A+R
Sbjct: 684 LLVRAGAKLDIQDKDGDTPLHEALR 708
Score = 60.5 bits (145), Expect = 2e-09
Identities = 40/160 (25%), Positives = 75/160 (46%), Gaps = 1/160 (0%)
Query: 142 EITGPVDEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKL 200
++ G T ++AA + G + +++ L + D+ A+H A+ ++E L
Sbjct: 457 DVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVL 516
Query: 201 LDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQV 260
A ++ +++ T +H A GHL+VVK L G +++D TPLH A+ +
Sbjct: 517 HRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRD 576
Query: 261 EIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLL 300
+I+ L G ++ + G ALH A +++LL
Sbjct: 577 DILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616
Score = 53.1 bits (126), Expect = 4e-07
Identities = 46/166 (27%), Positives = 76/166 (45%), Gaps = 4/166 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A +G ++V++ L G D T LH A + +IL LL+ GA V +
Sbjct: 537 AVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNG 596
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLS---TPLHVAVRTGQVEIVEHFLSLG- 270
A+H A G+ +++L S + D+ T LH+A VE+ E + G
Sbjct: 597 FNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGN 656
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++ ++ TALH AV +I++LL+ GA + ++ G TP
Sbjct: 657 ANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 94.4 bits (233), Expect = 1e-19
Identities = 55/161 (34%), Positives = 79/161 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +M++ L G + + T LH AS EGH +++ LLD GA + +
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T++H A + + V +L HGAD + KL TPL VA G V++V L G +N
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 734
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
A+ + G T LH A + II +LL HGA G T
Sbjct: 735 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 775
Score = 89.0 bits (219), Expect = 6e-18
Identities = 56/162 (34%), Positives = 81/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ L +G S D + TALH A+ G +E++ LL NGA VD + R +
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 476
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R G E+V+LL H A + TPLH++ R GQV++ L G +
Sbjct: 477 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 536
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + KLLL A + G TP
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 578
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/150 (32%), Positives = 85/150 (56%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + + ++L G +TC+Q ALH A+ EGH+ ++++LL G++VD
Sbjct: 13 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
+ TA+H A G EVVK+L GA+ N + + TPL++A + +++V++ L G
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLL 300
+ +G T L A++ + + +LL
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Score = 85.5 bits (210), Expect = 7e-17
Identities = 55/162 (33%), Positives = 81/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++KV+E + G S + T +H A+ GH+ I+ LL NGA+ D +
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 443
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+H A R G +EVV+ L +GA + R + TPLH+A R G+ EIV+ L +
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 503
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A G T LH + R + + +LL GA G TP
Sbjct: 504 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
Score = 84.3 bits (207), Expect = 2e-16
Identities = 57/162 (35%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V L G + D + T LH AS G+ +++ LLD G +D + R
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH +VV+LL GA R K +PLH+A + VE V+H L ++
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ TALH A Y++ KLLL A+ + L G TP
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTP 380
Score = 84.0 bits (206), Expect = 2e-16
Identities = 58/160 (36%), Positives = 82/160 (51%), Gaps = 3/160 (1%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A + ++++E L+ GA++ T +H A GHL +V LL +GA +V
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ T LH+A R GQVE+V L G ++AR RE T LH A RL + +I++LLL H
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 303 GADMMTKNLAGKTPTDL-VQLWQADTRHALEHPEPGAEHN 341
A G TP + + Q D L E GA H+
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVL--LEAGAAHS 536
Score = 76.3 bits (186), Expect = 4e-14
Identities = 47/162 (29%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V + L +AD+ + T LH A+ + ++ LL+ GA+ +
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + +++ L ++GA+TN+ K TPLH+A + G ++V L G I+
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ G T+LH A + ++ + +L HGAD G TP
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 710
Score = 75.5 bits (184), Expect = 7e-14
Identities = 50/151 (33%), Positives = 72/151 (47%), Gaps = 11/151 (7%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A+ G++ + LL+ GA VDF R T +H A + G+ +VKLL G +
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ + TPLH A R+G ++VE L G + AR + G + LH A + + + +K LL H
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Query: 303 GADMMTKNLAGKTPTDLVQLWQADTRHALEH 333
K P D V L H H
Sbjct: 334 -----------KAPVDDVTLDYLTALHVAAH 353
Score = 72.4 bits (176), Expect = 6e-13
Identities = 55/179 (30%), Positives = 87/179 (48%), Gaps = 14/179 (7%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A+ GH + + LLD A + + T +H AC+ ++V++LL +GA
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ TP+HVA G + IV L G + + G+TALH A R + ++++ LL +
Sbjct: 406 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
Query: 303 GADMMTKNLAGKTP---------TDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRE 352
GA + + +TP T++VQL + HP+ A NG + S RE
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQL----LLQHMAHPD-AATTNGYTPLHISARE 519
Score = 71.2 bits (173), Expect = 1e-12
Identities = 52/173 (30%), Positives = 78/173 (45%), Gaps = 1/173 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
+E+T L A GK ++++ L D T LH ++ EG +++ LL+ GA
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ T +H A + G L+V KLL A + K TPLHVA ++
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
L G +A + G T LH A + N+ +I LL +GA+ G TP L
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL 647
Score = 70.1 bits (170), Expect = 3e-12
Identities = 40/130 (30%), Positives = 70/130 (53%)
Query: 187 RASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKL 246
RA+ G+++ + + L G ++ ++ A+H A + GH+ +V+ L G+ + K
Sbjct: 16 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
Query: 247 LSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
+T LH+A GQ E+V+ + G INA+ + G T L+ A + N ++K LL +GA+
Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
Query: 307 MTKNLAGKTP 316
T G TP
Sbjct: 136 STATEDGFTP 145
Score = 69.7 bits (169), Expect = 4e-12
Identities = 52/185 (28%), Positives = 83/185 (44%), Gaps = 12/185 (6%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG ++ L G + + T+LH A+ E + + + L +GA D +L
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T + AC G++++V L GA+ N + K TPLH A + G I+ L G + N
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHP 334
A G+TAL A RL ++ L + ++ T T T + + +H L P
Sbjct: 768 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT------TTTTITE------KHKLNVP 815
Query: 335 EPGAE 339
E E
Sbjct: 816 ETMTE 820
Score = 68.6 bits (166), Expect = 9e-12
Identities = 48/165 (29%), Positives = 76/165 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
+A EG++ V L G + + T LH A+ G +++ + LL A D +
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 575
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + +V LL GA + K TPLH+A + Q++I L+ G E N
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 635
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
++G T LH A + ++ LLL GA++ +G T L
Sbjct: 636 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 680
Score = 63.9 bits (154), Expect = 2e-10
Identities = 48/199 (24%), Positives = 86/199 (43%), Gaps = 37/199 (18%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV------- 207
A++ G+ +V++ + +G + + Q T L+ A+ E H+++++ LL+NGA
Sbjct: 83 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 142
Query: 208 ----------------------DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDK 245
D + ++ A+H A R + LL + + +V+ K
Sbjct: 143 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202
Query: 246 LL--------STPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIK 297
++ TPLH+A G V + L+ G ++ R G T LH A + ++K
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262
Query: 298 LLLLHGADMMTKNLAGKTP 316
LLL G + K G TP
Sbjct: 263 LLLDRGGQIDAKTRDGLTP 281
Score = 33.9 bits (76), Expect = 0.23
Identities = 19/69 (27%), Positives = 34/69 (49%)
Query: 254 AVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 313
A R G ++ V +L G++IN ++ G ALH A + +++ LL G+ + + G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 314 KTPTDLVQL 322
T + L
Sbjct: 77 NTALHIASL 85
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 94.4 bits (233), Expect = 1e-19
Identities = 55/161 (34%), Positives = 79/161 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +M++ L G + + T LH AS EGH +++ LLD GA + +
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T++H A + + V +L HGAD + KL TPL VA G V++V L G +N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
A+ + G T LH A + II +LL HGA G T
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 796
Score = 89.0 bits (219), Expect = 6e-18
Identities = 56/162 (34%), Positives = 81/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ L +G S D + TALH A+ G +E++ LL NGA VD + R +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R G E+V+LL H A + TPLH++ R GQV++ L G +
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + KLLL A + G TP
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/150 (32%), Positives = 85/150 (56%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + + ++L G +TC+Q ALH A+ EGH+ ++++LL G++VD
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
+ TA+H A G EVVK+L GA+ N + + TPL++A + +++V++ L G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLL 300
+ +G T L A++ + + +LL
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 85.5 bits (210), Expect = 7e-17
Identities = 55/162 (33%), Positives = 81/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++KV+E + G S + T +H A+ GH+ I+ LL NGA+ D +
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+H A R G +EVV+ L +GA + R + TPLH+A R G+ EIV+ L +
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A G T LH + R + + +LL GA G TP
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Score = 84.3 bits (207), Expect = 2e-16
Identities = 57/162 (35%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V L G + D + T LH AS G+ +++ LLD G +D + R
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH +VV+LL GA R K +PLH+A + VE V+H L ++
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ TALH A Y++ KLLL A+ + L G TP
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTP 401
Score = 84.0 bits (206), Expect = 2e-16
Identities = 58/160 (36%), Positives = 82/160 (51%), Gaps = 3/160 (1%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A + ++++E L+ GA++ T +H A GHL +V LL +GA +V
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ T LH+A R GQVE+V L G ++AR RE T LH A RL + +I++LLL H
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 303 GADMMTKNLAGKTPTDL-VQLWQADTRHALEHPEPGAEHN 341
A G TP + + Q D L E GA H+
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVL--LEAGAAHS 557
Score = 76.3 bits (186), Expect = 4e-14
Identities = 47/162 (29%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V + L +AD+ + T LH A+ + ++ LL+ GA+ +
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + +++ L ++GA+TN+ K TPLH+A + G ++V L G I+
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ G T+LH A + ++ + +L HGAD G TP
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731
Score = 75.5 bits (184), Expect = 7e-14
Identities = 50/151 (33%), Positives = 72/151 (47%), Gaps = 11/151 (7%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A+ G++ + LL+ GA VDF R T +H A + G+ +VKLL G +
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ + TPLH A R+G ++VE L G + AR + G + LH A + + + +K LL H
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 303 GADMMTKNLAGKTPTDLVQLWQADTRHALEH 333
K P D V L H H
Sbjct: 355 -----------KAPVDDVTLDYLTALHVAAH 374
Score = 72.4 bits (176), Expect = 6e-13
Identities = 55/179 (30%), Positives = 87/179 (48%), Gaps = 14/179 (7%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A+ GH + + LLD A + + T +H AC+ ++V++LL +GA
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ TP+HVA G + IV L G + + G+TALH A R + ++++ LL +
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
Query: 303 GADMMTKNLAGKTP---------TDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRE 352
GA + + +TP T++VQL + HP+ A NG + S RE
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQL----LLQHMAHPD-AATTNGYTPLHISARE 540
Score = 71.2 bits (173), Expect = 1e-12
Identities = 52/173 (30%), Positives = 78/173 (45%), Gaps = 1/173 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
+E+T L A GK ++++ L D T LH ++ EG +++ LL+ GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ T +H A + G L+V KLL A + K TPLHVA ++
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
L G +A + G T LH A + N+ +I LL +GA+ G TP L
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL 668
Score = 70.1 bits (170), Expect = 3e-12
Identities = 40/130 (30%), Positives = 70/130 (53%)
Query: 187 RASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKL 246
RA+ G+++ + + L G ++ ++ A+H A + GH+ +V+ L G+ + K
Sbjct: 37 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 247 LSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
+T LH+A GQ E+V+ + G INA+ + G T L+ A + N ++K LL +GA+
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 307 MTKNLAGKTP 316
T G TP
Sbjct: 157 STATEDGFTP 166
Score = 69.7 bits (169), Expect = 4e-12
Identities = 52/185 (28%), Positives = 83/185 (44%), Gaps = 12/185 (6%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG ++ L G + + T+LH A+ E + + + L +GA D +L
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T + AC G++++V L GA+ N + K TPLH A + G I+ L G + N
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHP 334
A G+TAL A RL ++ L + ++ T T T + + +H L P
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT------TTTTITE------KHKLNVP 836
Query: 335 EPGAE 339
E E
Sbjct: 837 ETMTE 841
Score = 68.6 bits (166), Expect = 9e-12
Identities = 48/165 (29%), Positives = 76/165 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
+A EG++ V L G + + T LH A+ G +++ + LL A D +
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + +V LL GA + K TPLH+A + Q++I L+ G E N
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
++G T LH A + ++ LLL GA++ +G T L
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701
Score = 63.9 bits (154), Expect = 2e-10
Identities = 48/199 (24%), Positives = 86/199 (43%), Gaps = 37/199 (18%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV------- 207
A++ G+ +V++ + +G + + Q T L+ A+ E H+++++ LL+NGA
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 208 ----------------------DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDK 245
D + ++ A+H A R + LL + + +V+ K
Sbjct: 164 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 246 LL--------STPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIK 297
++ TPLH+A G V + L+ G ++ R G T LH A + ++K
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 298 LLLLHGADMMTKNLAGKTP 316
LLL G + K G TP
Sbjct: 284 LLLDRGGQIDAKTRDGLTP 302
Score = 33.9 bits (76), Expect = 0.23
Identities = 19/69 (27%), Positives = 34/69 (49%)
Query: 254 AVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 313
A R G ++ V +L G++IN ++ G ALH A + +++ LL G+ + + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 314 KTPTDLVQL 322
T + L
Sbjct: 98 NTALHIASL 106
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 94.4 bits (233), Expect = 1e-19
Identities = 55/161 (34%), Positives = 79/161 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +M++ L G + + T LH AS EGH +++ LLD GA + +
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T++H A + + V +L HGAD + KL TPL VA G V++V L G +N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
A+ + G T LH A + II +LL HGA G T
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNT 796
Score = 89.0 bits (219), Expect = 6e-18
Identities = 56/162 (34%), Positives = 81/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ L +G S D + TALH A+ G +E++ LL NGA VD + R +
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREE 497
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R G E+V+LL H A + TPLH++ R GQV++ L G +
Sbjct: 498 QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHS 557
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + KLLL A + G TP
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/150 (32%), Positives = 85/150 (56%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + + ++L G +TC+Q ALH A+ EGH+ ++++LL G++VD
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
+ TA+H A G EVVK+L GA+ N + + TPL++A + +++V++ L G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLL 300
+ +G T L A++ + + +LL
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 85.5 bits (210), Expect = 7e-17
Identities = 55/162 (33%), Positives = 81/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++KV+E + G S + T +H A+ GH+ I+ LL NGA+ D +
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+H A R G +EVV+ L +GA + R + TPLH+A R G+ EIV+ L +
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A G T LH + R + + +LL GA G TP
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Score = 84.3 bits (207), Expect = 2e-16
Identities = 57/162 (35%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V L G + D + T LH AS G+ +++ LLD G +D + R
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH +VV+LL GA R K +PLH+A + VE V+H L ++
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ TALH A Y++ KLLL A+ + L G TP
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTP 401
Score = 84.0 bits (206), Expect = 2e-16
Identities = 58/160 (36%), Positives = 82/160 (51%), Gaps = 3/160 (1%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A + ++++E L+ GA++ T +H A GHL +V LL +GA +V
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ T LH+A R GQVE+V L G ++AR RE T LH A RL + +I++LLL H
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 303 GADMMTKNLAGKTPTDL-VQLWQADTRHALEHPEPGAEHN 341
A G TP + + Q D L E GA H+
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVL--LEAGAAHS 557
Score = 76.3 bits (186), Expect = 4e-14
Identities = 47/162 (29%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V + L +AD+ + T LH A+ + ++ LL+ GA+ +
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + +++ L ++GA+TN+ K TPLH+A + G ++V L G I+
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ G T+LH A + ++ + +L HGAD G TP
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731
Score = 75.5 bits (184), Expect = 7e-14
Identities = 50/151 (33%), Positives = 72/151 (47%), Gaps = 11/151 (7%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A+ G++ + LL+ GA VDF R T +H A + G+ +VKLL G +
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ + TPLH A R+G ++VE L G + AR + G + LH A + + + +K LL H
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 303 GADMMTKNLAGKTPTDLVQLWQADTRHALEH 333
K P D V L H H
Sbjct: 355 -----------KAPVDDVTLDYLTALHVAAH 374
Score = 72.4 bits (176), Expect = 6e-13
Identities = 55/179 (30%), Positives = 87/179 (48%), Gaps = 14/179 (7%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A+ GH + + LLD A + + T +H AC+ ++V++LL +GA
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ TP+HVA G + IV L G + + G+TALH A R + ++++ LL +
Sbjct: 427 ITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 486
Query: 303 GADMMTKNLAGKTP---------TDLVQLWQADTRHALEHPEPGAEHNGLEGPNDSGRE 352
GA + + +TP T++VQL + HP+ A NG + S RE
Sbjct: 487 GALVDARAREEQTPLHIASRLGKTEIVQL----LLQHMAHPD-AATTNGYTPLHISARE 540
Score = 71.2 bits (173), Expect = 1e-12
Identities = 52/173 (30%), Positives = 78/173 (45%), Gaps = 1/173 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
+E+T L A GK ++++ L D T LH ++ EG +++ LL+ GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ T +H A + G L+V KLL A + K TPLHVA ++
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
L G +A + G T LH A + N+ +I LL +GA+ G TP L
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL 668
Score = 70.1 bits (170), Expect = 3e-12
Identities = 40/130 (30%), Positives = 70/130 (53%)
Query: 187 RASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKL 246
RA+ G+++ + + L G ++ ++ A+H A + GH+ +V+ L G+ + K
Sbjct: 37 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 247 LSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
+T LH+A GQ E+V+ + G INA+ + G T L+ A + N ++K LL +GA+
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 307 MTKNLAGKTP 316
T G TP
Sbjct: 157 STATEDGFTP 166
Score = 69.7 bits (169), Expect = 4e-12
Identities = 52/185 (28%), Positives = 83/185 (44%), Gaps = 12/185 (6%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG ++ L G + + T+LH A+ E + + + L +GA D +L
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T + AC G++++V L GA+ N + K TPLH A + G I+ L G + N
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHP 334
A G+TAL A RL ++ L + ++ T T T + + +H L P
Sbjct: 789 ATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT------TTTTITE------KHKLNVP 836
Query: 335 EPGAE 339
E E
Sbjct: 837 ETMTE 841
Score = 68.6 bits (166), Expect = 9e-12
Identities = 48/165 (29%), Positives = 76/165 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
+A EG++ V L G + + T LH A+ G +++ + LL A D +
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + +V LL GA + K TPLH+A + Q++I L+ G E N
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
++G T LH A + ++ LLL GA++ +G T L
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701
Score = 63.9 bits (154), Expect = 2e-10
Identities = 48/199 (24%), Positives = 86/199 (43%), Gaps = 37/199 (18%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV------- 207
A++ G+ +V++ + +G + + Q T L+ A+ E H+++++ LL+NGA
Sbjct: 104 ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 163
Query: 208 ----------------------DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDK 245
D + ++ A+H A R + LL + + +V+ K
Sbjct: 164 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
Query: 246 LL--------STPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIK 297
++ TPLH+A G V + L+ G ++ R G T LH A + ++K
Sbjct: 224 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 283
Query: 298 LLLLHGADMMTKNLAGKTP 316
LLL G + K G TP
Sbjct: 284 LLLDRGGQIDAKTRDGLTP 302
Score = 33.9 bits (76), Expect = 0.23
Identities = 19/69 (27%), Positives = 34/69 (49%)
Query: 254 AVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 313
A R G ++ V +L G++IN ++ G ALH A + +++ LL G+ + + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 314 KTPTDLVQL 322
T + L
Sbjct: 98 NTALHIASL 106
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 93.6 bits (231), Expect = 2e-19
Identities = 60/179 (33%), Positives = 89/179 (49%), Gaps = 3/179 (1%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 363 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRT 257
E LL GA++D T +H A GHL +VK L GA NV + + TPLH+A R
Sbjct: 421 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 480
Query: 258 GQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G E+ ++ L ++NA+ ++ T LH A R+ ++KLLL + A+ AG TP
Sbjct: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 539
Score = 85.1 bits (209), Expect = 9e-17
Identities = 53/162 (32%), Positives = 79/162 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH +VKLL + A+ N+ TPLH+A R G VE V L
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + ++ +LLL A G TP
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 605
Score = 85.1 bits (209), Expect = 9e-17
Identities = 51/162 (31%), Positives = 82/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H + GH+ V +L HG + ++ TPLHVA G +++V+ L ++N
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A+ + G + LH A + I+ LLL +GA + G TP
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803
Score = 84.3 bits (207), Expect = 2e-16
Identities = 50/162 (30%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + GH E+V LL S A+ N+ +K TPLH+ + G V + + + G+ ++
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A R G T LH A K++K LL H AD+ K G +P
Sbjct: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 770
Score = 82.0 bits (201), Expect = 7e-16
Identities = 54/162 (33%), Positives = 72/162 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH EV K L + A N + K TPLH A R G +V+ L N
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G T LH A R + + LL A G TP
Sbjct: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 572
Score = 78.6 bits (192), Expect = 8e-15
Identities = 54/201 (26%), Positives = 94/201 (46%), Gaps = 3/201 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 266
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 326
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
HGA + K +P+H+A + ++ V L EI+ + T LH A +++
Sbjct: 327 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 386
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
K+LL GA ++ L G TP
Sbjct: 387 AKVLLDKGAKPNSRALNGFTP 407
Score = 78.2 bits (191), Expect = 1e-14
Identities = 52/181 (28%), Positives = 81/181 (44%), Gaps = 14/181 (7%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A G++++VK L H AD N + KL +PLH A + G +IV L G N
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHP 334
+G T L A RL + +L K TD +H + P
Sbjct: 795 EVSSDGTTPLAIAKRLGYISVTDVL--------------KVVTDETSFVLVSDKHRMSFP 840
Query: 335 E 335
E
Sbjct: 841 E 841
Score = 77.0 bits (188), Expect = 2e-14
Identities = 50/188 (26%), Positives = 94/188 (50%), Gaps = 6/188 (3%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
++ +K++++ R S + + + T +FL+AA G + L +G +
Sbjct: 19 LQEQKEKEESNRKRRNRSRDRKKKADAAT------SFLRAARSGNLDKALDHLRNGVDIN 72
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
TC+Q LH AS EGH++++ +LL ++ + TA+H A G EVV+ L +
Sbjct: 73 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 132
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
+GA+ N + + TPL++A + +E+V+ L G N +G T L A++ +
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 192
Query: 296 IKLLLLHG 303
+ L+ +G
Sbjct: 193 VAHLINYG 200
Score = 76.3 bits (186), Expect = 4e-14
Identities = 59/195 (30%), Positives = 81/195 (41%), Gaps = 33/195 (16%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ---- 210
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + +
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338
Query: 211 ----------DRLDC-------------------TAMHWACRGGHLEVVKLLQSHGADTN 241
D LDC T +H A GH V K+L GA N
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398
Query: 242 VRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLL 301
R TPLH+A + V ++E L G I+A G T LH A + I+K LL
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 458
Query: 302 HGADMMTKNLAGKTP 316
GA N+ +TP
Sbjct: 459 RGASPNVSNVKVETP 473
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 29/191 (15%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG---- 270
T ++ A + HLEVVK L +GA+ NV + TPL VA++ G +V H ++ G
Sbjct: 145 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 204
Query: 271 -----LEINARD--------------------REGDTALHDAVRLNRYKIIKLLLLHGAD 305
L I AR+ + G T LH A + +LLL GA
Sbjct: 205 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 264
Query: 306 MMTKNLAGKTP 316
+ G TP
Sbjct: 265 VNFTPQNGITP 275
Score = 74.3 bits (181), Expect = 2e-13
Identities = 51/173 (29%), Positives = 83/173 (47%), Gaps = 1/173 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 502 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ T +H A + G + V +LL A N K TPLHVAV ++IV+
Sbjct: 562 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
L G ++ G T LH A + N+ ++ + LL +G +++ G TP L
Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 674
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/166 (30%), Positives = 76/166 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A +L++VKLL G + TPLH+A + QVE+ L G N
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV 320
A +G T LH A + +++ LLL A+ N +G TP LV
Sbjct: 663 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708
Score = 69.3 bits (168), Expect = 5e-12
Identities = 46/141 (32%), Positives = 65/141 (46%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
GA N + TPLH+A R G V +V L G +I + ++ T LH A R +I
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 320
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
++LL HGA + K G +P
Sbjct: 321 SEILLDHGAPIQAKTKNGLSP 341
Score = 63.9 bits (154), Expect = 2e-10
Identities = 38/134 (28%), Positives = 68/134 (50%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
K +T LH+A GQ E+V ++ G +NA+ ++G T L+ A + N +++K LL +
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 303 GADMMTKNLAGKTP 316
GA+ G TP
Sbjct: 167 GANQNVATEDGFTP 180
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 93.6 bits (231), Expect = 2e-19
Identities = 60/179 (33%), Positives = 89/179 (49%), Gaps = 3/179 (1%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 330 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRT 257
E LL GA++D T +H A GHL +VK L GA NV + + TPLH+A R
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 258 GQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G E+ ++ L ++NA+ ++ T LH A R+ ++KLLL + A+ AG TP
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Score = 85.1 bits (209), Expect = 9e-17
Identities = 53/162 (32%), Positives = 79/162 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH +VKLL + A+ N+ TPLH+A R G VE V L
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + ++ +LLL A G TP
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572
Score = 85.1 bits (209), Expect = 9e-17
Identities = 51/162 (31%), Positives = 82/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H + GH+ V +L HG + ++ TPLHVA G +++V+ L ++N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A+ + G + LH A + I+ LLL +GA + G TP
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
Score = 84.3 bits (207), Expect = 2e-16
Identities = 50/162 (30%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + GH E+V LL S A+ N+ +K TPLH+ + G V + + + G+ ++
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A R G T LH A K++K LL H AD+ K G +P
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 737
Score = 82.0 bits (201), Expect = 7e-16
Identities = 54/162 (33%), Positives = 72/162 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH EV K L + A N + K TPLH A R G +V+ L N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G T LH A R + + LL A G TP
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Score = 79.0 bits (193), Expect = 6e-15
Identities = 57/198 (28%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A G++++VK L H AD N + KL +PLH A + G +IV L G N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHP 334
+G T L A RL + +L K TD +H + P
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVL--------------KVVTDETSFVLVSDKHRMSFP 807
Query: 335 EPGAEHNGLEGPNDSGRE 352
E E L+ D G E
Sbjct: 808 ETVDEI--LDVSEDEGEE 823
Score = 78.6 bits (192), Expect = 8e-15
Identities = 54/201 (26%), Positives = 94/201 (46%), Gaps = 3/201 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 233
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
HGA + K +P+H+A + ++ V L EI+ + T LH A +++
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
K+LL GA ++ L G TP
Sbjct: 354 AKVLLDKGAKPNSRALNGFTP 374
Score = 76.6 bits (187), Expect = 3e-14
Identities = 46/153 (30%), Positives = 80/153 (52%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + L +G +TC+Q LH AS EGH++++ +LL ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
+ TA+H A G EVV+ L ++GA+ N + + TPL++A + +E+V+ L G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLLLHG 303
N +G T L A++ ++ L+ +G
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 76.3 bits (186), Expect = 4e-14
Identities = 59/195 (30%), Positives = 81/195 (41%), Gaps = 33/195 (16%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ---- 210
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 211 ----------DRLDC-------------------TAMHWACRGGHLEVVKLLQSHGADTN 241
D LDC T +H A GH V K+L GA N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 242 VRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLL 301
R TPLH+A + V ++E L G I+A G T LH A + I+K LL
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 302 HGADMMTKNLAGKTP 316
GA N+ +TP
Sbjct: 426 RGASPNVSNVKVETP 440
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 29/191 (15%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG---- 270
T ++ A + HLEVVK L +GA+ NV + TPL VA++ G +V H ++ G
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 271 -----LEINARD--------------------REGDTALHDAVRLNRYKIIKLLLLHGAD 305
L I AR+ + G T LH A + +LLL GA
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 306 MMTKNLAGKTP 316
+ G TP
Sbjct: 232 VNFTPQNGITP 242
Score = 74.3 bits (181), Expect = 2e-13
Identities = 51/173 (29%), Positives = 83/173 (47%), Gaps = 1/173 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ T +H A + G + V +LL A N K TPLHVAV ++IV+
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
L G ++ G T LH A + N+ ++ + LL +G +++ G TP L
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/166 (30%), Positives = 76/166 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A +L++VKLL G + TPLH+A + QVE+ L G N
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV 320
A +G T LH A + +++ LLL A+ N +G TP LV
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Score = 69.3 bits (168), Expect = 5e-12
Identities = 46/141 (32%), Positives = 65/141 (46%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
GA N + TPLH+A R G V +V L G +I + ++ T LH A R +I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
++LL HGA + K G +P
Sbjct: 288 SEILLDHGAPIQAKTKNGLSP 308
Score = 63.9 bits (154), Expect = 2e-10
Identities = 38/134 (28%), Positives = 68/134 (50%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
K +T LH+A GQ E+V ++ G +NA+ ++G T L+ A + N +++K LL +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 303 GADMMTKNLAGKTP 316
GA+ G TP
Sbjct: 134 GANQNVATEDGFTP 147
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/111 (26%), Positives = 58/111 (52%)
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEH 265
+V F++ T+ A R G+L+ +G D N ++ LH+A + G V++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
L + + ++G+TALH A + ++++ L+ +GA++ ++ G TP
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTP 114
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 93.6 bits (231), Expect = 2e-19
Identities = 60/179 (33%), Positives = 89/179 (49%), Gaps = 3/179 (1%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 330 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRT 257
E LL GA++D T +H A GHL +VK L GA NV + + TPLH+A R
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 258 GQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G E+ ++ L ++NA+ ++ T LH A R+ ++KLLL + A+ AG TP
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Score = 85.1 bits (209), Expect = 9e-17
Identities = 53/162 (32%), Positives = 79/162 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH +VKLL + A+ N+ TPLH+A R G VE V L
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + ++ +LLL A G TP
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572
Score = 85.1 bits (209), Expect = 9e-17
Identities = 51/162 (31%), Positives = 82/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H + GH+ V +L HG + ++ TPLHVA G +++V+ L ++N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A+ + G + LH A + I+ LLL +GA + G TP
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
Score = 84.3 bits (207), Expect = 2e-16
Identities = 50/162 (30%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + GH E+V LL S A+ N+ +K TPLH+ + G V + + + G+ ++
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A R G T LH A K++K LL H AD+ K G +P
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 737
Score = 82.0 bits (201), Expect = 7e-16
Identities = 54/162 (33%), Positives = 72/162 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH EV K L + A N + K TPLH A R G +V+ L N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G T LH A R + + LL A G TP
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Score = 79.0 bits (193), Expect = 6e-15
Identities = 57/198 (28%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A G++++VK L H AD N + KL +PLH A + G +IV L G N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHP 334
+G T L A RL + +L K TD +H + P
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVL--------------KVVTDETSFVLVSDKHRMSFP 807
Query: 335 EPGAEHNGLEGPNDSGRE 352
E E L+ D G E
Sbjct: 808 ETVDEI--LDVSEDEGEE 823
Score = 78.6 bits (192), Expect = 8e-15
Identities = 54/201 (26%), Positives = 94/201 (46%), Gaps = 3/201 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 233
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
HGA + K +P+H+A + ++ V L EI+ + T LH A +++
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
K+LL GA ++ L G TP
Sbjct: 354 AKVLLDKGAKPNSRALNGFTP 374
Score = 76.6 bits (187), Expect = 3e-14
Identities = 46/153 (30%), Positives = 80/153 (52%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + L +G +TC+Q LH AS EGH++++ +LL ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
+ TA+H A G EVV+ L ++GA+ N + + TPL++A + +E+V+ L G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLLLHG 303
N +G T L A++ ++ L+ +G
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 76.3 bits (186), Expect = 4e-14
Identities = 59/195 (30%), Positives = 81/195 (41%), Gaps = 33/195 (16%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ---- 210
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 211 ----------DRLDC-------------------TAMHWACRGGHLEVVKLLQSHGADTN 241
D LDC T +H A GH V K+L GA N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 242 VRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLL 301
R TPLH+A + V ++E L G I+A G T LH A + I+K LL
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 302 HGADMMTKNLAGKTP 316
GA N+ +TP
Sbjct: 426 RGASPNVSNVKVETP 440
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 29/191 (15%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG---- 270
T ++ A + HLEVVK L +GA+ NV + TPL VA++ G +V H ++ G
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 271 -----LEINARD--------------------REGDTALHDAVRLNRYKIIKLLLLHGAD 305
L I AR+ + G T LH A + +LLL GA
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 306 MMTKNLAGKTP 316
+ G TP
Sbjct: 232 VNFTPQNGITP 242
Score = 74.3 bits (181), Expect = 2e-13
Identities = 51/173 (29%), Positives = 83/173 (47%), Gaps = 1/173 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ T +H A + G + V +LL A N K TPLHVAV ++IV+
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
L G ++ G T LH A + N+ ++ + LL +G +++ G TP L
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/166 (30%), Positives = 76/166 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A +L++VKLL G + TPLH+A + QVE+ L G N
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV 320
A +G T LH A + +++ LLL A+ N +G TP LV
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Score = 69.3 bits (168), Expect = 5e-12
Identities = 46/141 (32%), Positives = 65/141 (46%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
GA N + TPLH+A R G V +V L G +I + ++ T LH A R +I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
++LL HGA + K G +P
Sbjct: 288 SEILLDHGAPIQAKTKNGLSP 308
Score = 63.9 bits (154), Expect = 2e-10
Identities = 38/134 (28%), Positives = 68/134 (50%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
K +T LH+A GQ E+V ++ G +NA+ ++G T L+ A + N +++K LL +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 303 GADMMTKNLAGKTP 316
GA+ G TP
Sbjct: 134 GANQNVATEDGFTP 147
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/111 (26%), Positives = 58/111 (52%)
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEH 265
+V F++ T+ A R G+L+ +G D N ++ LH+A + G V++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
L + + ++G+TALH A + ++++ L+ +GA++ ++ G TP
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTP 114
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 93.6 bits (231), Expect = 2e-19
Identities = 60/179 (33%), Positives = 89/179 (49%), Gaps = 3/179 (1%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 330 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRT 257
E LL GA++D T +H A GHL +VK L GA NV + + TPLH+A R
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 258 GQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G E+ ++ L ++NA+ ++ T LH A R+ ++KLLL + A+ AG TP
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Score = 85.1 bits (209), Expect = 9e-17
Identities = 53/162 (32%), Positives = 79/162 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH +VKLL + A+ N+ TPLH+A R G VE V L
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + ++ +LLL A G TP
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572
Score = 85.1 bits (209), Expect = 9e-17
Identities = 51/162 (31%), Positives = 82/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H + GH+ V +L HG + ++ TPLHVA G +++V+ L ++N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A+ + G + LH A + I+ LLL +GA + G TP
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
Score = 84.3 bits (207), Expect = 2e-16
Identities = 50/162 (30%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + GH E+V LL S A+ N+ +K TPLH+ + G V + + + G+ ++
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A R G T LH A K++K LL H AD+ K G +P
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 737
Score = 82.0 bits (201), Expect = 7e-16
Identities = 54/162 (33%), Positives = 72/162 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH EV K L + A N + K TPLH A R G +V+ L N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G T LH A R + + LL A G TP
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Score = 79.0 bits (193), Expect = 6e-15
Identities = 57/198 (28%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A G++++VK L H AD N + KL +PLH A + G +IV L G N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHP 334
+G T L A RL + +L K TD +H + P
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVL--------------KVVTDETSFVLVSDKHRMSFP 807
Query: 335 EPGAEHNGLEGPNDSGRE 352
E E L+ D G E
Sbjct: 808 ETVDEI--LDVSEDEGEE 823
Score = 78.6 bits (192), Expect = 8e-15
Identities = 54/201 (26%), Positives = 94/201 (46%), Gaps = 3/201 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 233
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
HGA + K +P+H+A + ++ V L EI+ + T LH A +++
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
K+LL GA ++ L G TP
Sbjct: 354 AKVLLDKGAKPNSRALNGFTP 374
Score = 76.6 bits (187), Expect = 3e-14
Identities = 46/153 (30%), Positives = 80/153 (52%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + L +G +TC+Q LH AS EGH++++ +LL ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
+ TA+H A G EVV+ L ++GA+ N + + TPL++A + +E+V+ L G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLLLHG 303
N +G T L A++ ++ L+ +G
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 76.3 bits (186), Expect = 4e-14
Identities = 59/195 (30%), Positives = 81/195 (41%), Gaps = 33/195 (16%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ---- 210
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 211 ----------DRLDC-------------------TAMHWACRGGHLEVVKLLQSHGADTN 241
D LDC T +H A GH V K+L GA N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 242 VRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLL 301
R TPLH+A + V ++E L G I+A G T LH A + I+K LL
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 302 HGADMMTKNLAGKTP 316
GA N+ +TP
Sbjct: 426 RGASPNVSNVKVETP 440
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 29/191 (15%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG---- 270
T ++ A + HLEVVK L +GA+ NV + TPL VA++ G +V H ++ G
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 271 -----LEINARD--------------------REGDTALHDAVRLNRYKIIKLLLLHGAD 305
L I AR+ + G T LH A + +LLL GA
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 306 MMTKNLAGKTP 316
+ G TP
Sbjct: 232 VNFTPQNGITP 242
Score = 74.3 bits (181), Expect = 2e-13
Identities = 51/173 (29%), Positives = 83/173 (47%), Gaps = 1/173 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ T +H A + G + V +LL A N K TPLHVAV ++IV+
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
L G ++ G T LH A + N+ ++ + LL +G +++ G TP L
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/166 (30%), Positives = 76/166 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A +L++VKLL G + TPLH+A + QVE+ L G N
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV 320
A +G T LH A + +++ LLL A+ N +G TP LV
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Score = 69.3 bits (168), Expect = 5e-12
Identities = 46/141 (32%), Positives = 65/141 (46%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
GA N + TPLH+A R G V +V L G +I + ++ T LH A R +I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
++LL HGA + K G +P
Sbjct: 288 SEILLDHGAPIQAKTKNGLSP 308
Score = 63.9 bits (154), Expect = 2e-10
Identities = 38/134 (28%), Positives = 68/134 (50%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
K +T LH+A GQ E+V ++ G +NA+ ++G T L+ A + N +++K LL +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 303 GADMMTKNLAGKTP 316
GA+ G TP
Sbjct: 134 GANQNVATEDGFTP 147
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/111 (26%), Positives = 58/111 (52%)
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEH 265
+V F++ T+ A R G+L+ +G D N ++ LH+A + G V++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
L + + ++G+TALH A + ++++ L+ +GA++ ++ G TP
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTP 114
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 93.6 bits (231), Expect = 2e-19
Identities = 60/179 (33%), Positives = 89/179 (49%), Gaps = 3/179 (1%)
Query: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEIL 197
E ++IT +D T L A + K L D G+ T LH A + H+ ++
Sbjct: 330 EIDDIT--LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRT 257
E LL GA++D T +H A GHL +VK L GA NV + + TPLH+A R
Sbjct: 388 ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA 447
Query: 258 GQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G E+ ++ L ++NA+ ++ T LH A R+ ++KLLL + A+ AG TP
Sbjct: 448 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Score = 85.1 bits (209), Expect = 9e-17
Identities = 53/162 (32%), Positives = 79/162 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G + +++ L G S + + T LH A+ GH E+ + LL N A V+ + + D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH +VKLL + A+ N+ TPLH+A R G VE V L
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + ++ +LLL A G TP
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTP 572
Score = 85.1 bits (209), Expect = 9e-17
Identities = 51/162 (31%), Positives = 82/162 (50%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +++V L GGSA+ T LH A+ EGH E++ LL A + ++
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H + GH+ V +L HG + ++ TPLHVA G +++V+ L ++N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A+ + G + LH A + I+ LLL +GA + G TP
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
Score = 84.3 bits (207), Expect = 2e-16
Identities = 50/162 (30%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + +++ L GGS + T LH A+ + +E+ LL G + + +
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + GH E+V LL S A+ N+ +K TPLH+ + G V + + + G+ ++
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A R G T LH A K++K LL H AD+ K G +P
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 737
Score = 82.0 bits (201), Expect = 7e-16
Identities = 54/162 (33%), Positives = 72/162 (44%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++V+E L G S D + T LH AS GH+ I++ LL GA+ + +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R GH EV K L + A N + K TPLH A R G +V+ L N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G T LH A R + + LL A G TP
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTP 539
Score = 79.0 bits (193), Expect = 6e-15
Identities = 57/198 (28%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG +++ L+ + + ++ T LH + EGH+ + + L+ +G VD R+
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A G++++VK L H AD N + KL +PLH A + G +IV L G N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEHP 334
+G T L A RL + +L K TD +H + P
Sbjct: 762 EVSSDGTTPLAIAKRLGYISVTDVL--------------KVVTDETSFVLVSDKHRMSFP 807
Query: 335 EPGAEHNGLEGPNDSGRE 352
E E L+ D G E
Sbjct: 808 ETVDEI--LDVSEDEGEE 823
Score = 78.6 bits (192), Expect = 8e-15
Identities = 54/201 (26%), Positives = 94/201 (46%), Gaps = 3/201 (1%)
Query: 116 IELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSAD 175
+ + + + A+ ++P P+ TG AA + V + L G S +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHI---AAHYENLNVAQLLLNRGASVN 233
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
Q T LH AS G++ ++ LLD GA ++ + + + T +H A R GH+ + ++L
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
HGA + K +P+H+A + ++ V L EI+ + T LH A +++
Sbjct: 294 HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRV 353
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
K+LL GA ++ L G TP
Sbjct: 354 AKVLLDKGAKPNSRALNGFTP 374
Score = 76.6 bits (187), Expect = 3e-14
Identities = 46/153 (30%), Positives = 80/153 (52%)
Query: 151 TFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ 210
+FL+AA G + L +G +TC+Q LH AS EGH++++ +LL ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG 270
+ TA+H A G EVV+ L ++GA+ N + + TPL++A + +E+V+ L G
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLLLHG 303
N +G T L A++ ++ L+ +G
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 76.3 bits (186), Expect = 4e-14
Identities = 59/195 (30%), Positives = 81/195 (41%), Gaps = 33/195 (16%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ---- 210
A+ G + ++ L G +T + T LH A+ GH+ I E LLD+GA + +
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 211 ----------DRLDC-------------------TAMHWACRGGHLEVVKLLQSHGADTN 241
D LDC T +H A GH V K+L GA N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 242 VRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLL 301
R TPLH+A + V ++E L G I+A G T LH A + I+K LL
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 302 HGADMMTKNLAGKTP 316
GA N+ +TP
Sbjct: 426 RGASPNVSNVKVETP 440
Score = 75.5 bits (184), Expect = 7e-14
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 29/191 (15%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG +K++ + L +T + TALH A+L G E++ +L++ GA V+ Q +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG---- 270
T ++ A + HLEVVK L +GA+ NV + TPL VA++ G +V H ++ G
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 271 -----LEINARD--------------------REGDTALHDAVRLNRYKIIKLLLLHGAD 305
L I AR+ + G T LH A + +LLL GA
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 306 MMTKNLAGKTP 316
+ G TP
Sbjct: 232 VNFTPQNGITP 242
Score = 74.3 bits (181), Expect = 2e-13
Identities = 51/173 (29%), Positives = 83/173 (47%), Gaps = 1/173 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L A G +++ L + + + T LH A+ EGH+E + LL+ A+
Sbjct: 469 DDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ T +H A + G + V +LL A N K TPLHVAV ++IV+
Sbjct: 529 QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
L G ++ G T LH A + N+ ++ + LL +G +++ G TP L
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/166 (30%), Positives = 76/166 (45%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG ++ + L S + T LH A+ G + + E LL+ A + +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A +L++VKLL G + TPLH+A + QVE+ L G N
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV 320
A +G T LH A + +++ LLL A+ N +G TP LV
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Score = 69.3 bits (168), Expect = 5e-12
Identities = 46/141 (32%), Positives = 65/141 (46%)
Query: 176 TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQS 235
T + R ALH A+ LL N D + T +H A +L V +LL +
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 236 HGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKI 295
GA N + TPLH+A R G V +V L G +I + ++ T LH A R +I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 296 IKLLLLHGADMMTKNLAGKTP 316
++LL HGA + K G +P
Sbjct: 288 SEILLDHGAPIQAKTKNGLSP 308
Score = 63.9 bits (154), Expect = 2e-10
Identities = 38/134 (28%), Positives = 68/134 (50%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T+ RA+ G+++ L NG ++ ++ +H A + GH+++V L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
K +T LH+A GQ E+V ++ G +NA+ ++G T L+ A + N +++K LL +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 303 GADMMTKNLAGKTP 316
GA+ G TP
Sbjct: 134 GANQNVATEDGFTP 147
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/111 (26%), Positives = 58/111 (52%)
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEH 265
+V F++ T+ A R G+L+ +G D N ++ LH+A + G V++V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 63
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
L + + ++G+TALH A + ++++ L+ +GA++ ++ G TP
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTP 114
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 92.8 bits (229), Expect = 4e-19
Identities = 54/152 (35%), Positives = 84/152 (55%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +G ++++++ + +G + + D TAL AS EGH+ I+E+LL G ++ +D
Sbjct: 45 AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+ WAC G +VV+LL SHGA+ +V P+ A G +IV L G ++N
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
D+ G T L A R + +K LL GAD+
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Score = 90.1 bits (222), Expect = 3e-18
Identities = 60/186 (32%), Positives = 91/186 (48%), Gaps = 3/186 (1%)
Query: 130 LAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRAS 189
L SH P +TG + AA G ++ L +G + D++ T L A+
Sbjct: 122 LLLSHGANPS---VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAA 178
Query: 190 LEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLST 249
+GH+E ++ LL GA VD + TA+ A +GG+ + VK + + N+ DK +T
Sbjct: 179 RKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNT 238
Query: 250 PLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTK 309
L +A + G EIV+ L G +N DR GDT L AVR +I++ LL AD+ +
Sbjct: 239 ALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR 298
Query: 310 NLAGKT 315
KT
Sbjct: 299 GQDNKT 304
Score = 85.9 bits (211), Expect = 5e-17
Identities = 54/168 (32%), Positives = 90/168 (53%), Gaps = 3/168 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ EG ++++ L G + D+ T L A GH+EI+ LL A +D + + +
Sbjct: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA++WA G+ +V+ + DT + K TPL A + +E+VE L G +++
Sbjct: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGAD---MMTKNLAGKTPTDL 319
A D++GDT LH A+R K+ +LLL + D + N AG+TP ++
Sbjct: 363 AVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 85.5 bits (210), Expect = 7e-17
Identities = 58/176 (32%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 147 VDEE-----TFLKAAVEGKM-KVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKL 200
VD+E T L AV+G + +++ L + + D+ TAL AS EGH EI++ L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 201 LDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQV 260
LD G V+ DR T + A RGGH+E+V+ L AD ++R + T L+ AV G
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 261 EIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+V L + ++G+T L A ++ ++++LLL GA + + G TP
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTP 371
Score = 66.2 bits (160), Expect = 4e-11
Identities = 49/162 (30%), Positives = 78/162 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +G ++ ++ LA G D TAL A G+ + ++++L V+ D+
Sbjct: 177 AARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG 236
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+ A + GH E+V+ L G N+ D+ T L AVR G VEIV L +I+
Sbjct: 237 NTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADID 296
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
R ++ TAL+ AV +++ +L D G+TP
Sbjct: 297 IRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETP 338
Score = 65.9 bits (159), Expect = 6e-11
Identities = 48/140 (34%), Positives = 68/140 (48%), Gaps = 4/140 (2%)
Query: 191 EGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTP 250
E ++ L+ LL+ VD ++ T + A G+LE+VK L +GA+ N+ D T
Sbjct: 15 EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
Query: 251 LHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKN 310
L A + G V IVE L G+ + RD G TAL A R +++LLL HGA+
Sbjct: 75 LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
Query: 311 LAGKTPTDLVQLWQADTRHA 330
L P +W A HA
Sbjct: 135 LYSVYPI----IWAAGRGHA 150
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 92.4 bits (228), Expect = 6e-19
Identities = 54/162 (33%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++KV+E L G S + T +H A+ GH+ I+ +L+ +GA+ + +
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+H A R G EVV+ L GA + K TPLH++ R G+ +IV+ L G N
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A G T LH + R + LL HGA + G TP
Sbjct: 527 AATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568
Score = 87.4 bits (215), Expect = 2e-17
Identities = 57/184 (30%), Positives = 96/184 (52%), Gaps = 11/184 (5%)
Query: 117 ELRKKRKQKKRDALAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADT 176
E KKRK +KR S + + + ++L+AA G ++ ++ +G +
Sbjct: 21 EPEKKRKHRKR-----SRDRKKKSDA------NASYLRAARAGHLEKALDYIKNGVDINI 69
Query: 177 CDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSH 236
C+Q ALH AS EGH+E++ +LL A VD + TA+H A G EVVK+L ++
Sbjct: 70 CNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTN 129
Query: 237 GADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKII 296
GA+ N + + TPL++A + +E+V+ L G + +G T L A++ +++
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVV 189
Query: 297 KLLL 300
LLL
Sbjct: 190 SLLL 193
Score = 84.3 bits (207), Expect = 2e-16
Identities = 45/137 (32%), Positives = 72/137 (52%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH A + ++++E LL +GA++ T +H A GH+ +V L HGA N
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ T LH+A R+GQ E+V + + G ++ A+ ++ T LH + RL + I++ LL
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Query: 303 GADMMTKNLAGKTPTDL 319
GA +G TP L
Sbjct: 522 GASPNAATTSGYTPLHL 538
Score = 83.6 bits (205), Expect = 3e-16
Identities = 50/162 (30%), Positives = 77/162 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A+ G +++ L G D + T LH + GH +++E LLD A + + +
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 334
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
+ +H A +G HL V+LL H + T LHVA G ++ + L N
Sbjct: 335 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 394
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A+ G T LH A + NR K+++LLL HGA + +G TP
Sbjct: 395 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTP 436
Score = 82.8 bits (203), Expect = 4e-16
Identities = 47/162 (29%), Positives = 80/162 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + ++ + + G S +T + TALH A+ G E++ L+ +GA V+ + + D
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H + R G ++V+ L GA N TPLH++ R G ++ L G ++
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++G T LH A + + ++ LLL A +G TP
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTP 601
Score = 82.8 bits (203), Expect = 4e-16
Identities = 51/162 (31%), Positives = 78/162 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA KV L G S + T LH A+ + M+I LL+ GA + R
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
++H A + GH+++V LL A+ N+ +K TPLH+A + +V + E ++ G ++
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD 724
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
A+ + G T LH KI+ LL H A + K G TP
Sbjct: 725 AQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766
Score = 82.4 bits (202), Expect = 6e-16
Identities = 54/183 (29%), Positives = 83/183 (45%), Gaps = 3/183 (1%)
Query: 134 HEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGH 193
H P + G E AA G+ +V+ + DG + + +T LH ++ G
Sbjct: 455 HGASPNTTNVRG---ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511
Query: 194 MEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHV 253
+I+++LL GA+ + T +H + R GH +V L HGA ++ K TPLHV
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHV 571
Query: 254 AVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 313
A + G++E+ L +A + G T LH A + K+ LLL GA G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 314 KTP 316
TP
Sbjct: 632 YTP 634
Score = 80.9 bits (198), Expect = 2e-15
Identities = 46/161 (28%), Positives = 80/161 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + +M + L G A+ + ++H A+ EGH++++ LL A V+ ++
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + + V ++L + GA + + K+ TPLHV G ++IV L ++N
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
A+ + G T LH A + II +LL + A + G T
Sbjct: 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNT 798
Score = 80.1 bits (196), Expect = 3e-15
Identities = 51/159 (32%), Positives = 77/159 (48%), Gaps = 1/159 (0%)
Query: 148 DEETFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D++T L + GK ++++ L G S + T LH ++ EGH ++ LLD+GA+
Sbjct: 498 DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
+ + T +H A + G LEV LL A + K TPLHVA ++
Sbjct: 558 LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGAD 305
L G +A + G T LH A + N+ I LL +GAD
Sbjct: 618 LDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
Score = 78.2 bits (191), Expect = 1e-14
Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 1/145 (0%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A+ GH ++ + LLD A + + T +H AC+ ++V++LL HGA
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+ TP+HVA G V IV + G N + G+TALH A R + ++++ L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 303 GADMMTKNLAGKTPTDL-VQLWQAD 326
GA + K +TP + +L +AD
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKAD 513
Score = 76.6 bits (187), Expect = 3e-14
Identities = 46/154 (29%), Positives = 73/154 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG + ++ L + + ++ T LH A+ E + + E L++ GA VD Q ++
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H C G++++V L H A N + K TPLH A + G I+ L N
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMT 308
G+TAL A RL ++ L + + MT
Sbjct: 791 ELTVNGNTALGIARRLGYISVVDTLKIVTEETMT 824
Score = 75.1 bits (183), Expect = 9e-14
Identities = 42/130 (32%), Positives = 69/130 (53%)
Query: 187 RASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKL 246
RA+ GH+E + NG ++ ++ A+H A + GH+EVV L A+ + K
Sbjct: 47 RAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKK 106
Query: 247 LSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
+T LH+A GQ E+V+ ++ G +NA+ + G T L+ A + N +++K LL +GA
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 307 MTKNLAGKTP 316
G TP
Sbjct: 167 SLATEDGFTP 176
Score = 75.1 bits (183), Expect = 9e-14
Identities = 51/150 (34%), Positives = 75/150 (50%), Gaps = 4/150 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA + K L + +AD + T LH A+ G++ + LL+ A VDF R D
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 215 CTAMHWACRGGHLEVVKLLQSHGA--DTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
T +H A + G+ +VKLL GA D RD L TPLH R+G ++VE L
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL--TPLHCGARSGHEQVVEMLLDRAAP 326
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLH 302
I ++ + G + LH A + + ++LLL H
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/162 (31%), Positives = 77/162 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V L + D + T LH AS G+ +++ LLD GA +D + R
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H R GH +VV++L A + K +PLH+A + + V+ L + ++
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ TALH A YK+ K+LL A+ K L G TP
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTP 403
Score = 72.4 bits (176), Expect = 6e-13
Identities = 47/160 (29%), Positives = 75/160 (46%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A G +V+E L + + + LH A+ H+ ++ LL + VD
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINA 275
TA+H A GH +V K+L A+ N + TPLH+A + +++++E L G I A
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 276 RDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
G T +H A + I+ L+ HGA T N+ G+T
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
Score = 71.2 bits (173), Expect = 1e-12
Identities = 50/171 (29%), Positives = 83/171 (48%), Gaps = 7/171 (4%)
Query: 149 EETFLKAAV---EGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGA 205
E+ F AV +G +V+ L + DT + R ALH A+ + + LL N
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDN 226
Query: 206 TVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEH 265
D + + T +H A G++ V LL + A + + TPLHVA + G +V+
Sbjct: 227 NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
L G +I+A+ R+G T LH R +++++LL A +++K G +P
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSP 337
Score = 70.1 bits (170), Expect = 3e-12
Identities = 44/162 (27%), Positives = 76/162 (46%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA GK++V L S D + T LH A+ + ++ LLD GA+ +
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A + +++ L +GAD N + +H+A + G V++V L +N
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++ G T LH A + +R + ++L+ GA + + G TP
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733
Score = 67.0 bits (162), Expect = 2e-11
Identities = 48/191 (25%), Positives = 83/191 (43%), Gaps = 29/191 (15%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATV------- 207
A++ G+ +V++ + +G + + Q T L+ A+ E H+E+++ LLDNGA+
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG 173
Query: 208 ----------------------DFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDK 245
D + ++ A+H A R + LL + + +V K
Sbjct: 174 FTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK 233
Query: 246 LLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGAD 305
TPLH+A G + + L+ ++ R T LH A + ++KLLL GA
Sbjct: 234 SGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK 293
Query: 306 MMTKNLAGKTP 316
+ K G TP
Sbjct: 294 IDAKTRDGLTP 304
Score = 30.8 bits (68), Expect = 2.0
Identities = 18/69 (26%), Positives = 32/69 (46%)
Query: 254 AVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAG 313
A R G +E ++ G++IN ++ G ALH A + +++ LL A++ G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 314 KTPTDLVQL 322
T + L
Sbjct: 108 NTALHIASL 116
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 92.0 bits (227), Expect = 7e-19
Identities = 55/160 (34%), Positives = 81/160 (50%)
Query: 162 KVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWA 221
K + K A G + Q + LH A+L G +++ LL +GA ++ +H A
Sbjct: 725 KRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLA 784
Query: 222 CRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGD 281
C+ GH +VVK L A N +D +TPL A G E+V L G INA + +G+
Sbjct: 785 CQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGN 844
Query: 282 TALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQ 321
TALH+AV +++LLLLHGA + N +T D +
Sbjct: 845 TALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAE 884
Score = 72.8 bits (177), Expect = 5e-13
Identities = 49/145 (33%), Positives = 75/145 (51%), Gaps = 2/145 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G+ +I L G +A + + LH A +GH ++++ LLD+ A + +D
Sbjct: 751 AALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSG 810
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T + +AC GGH E+V LL HGA N + +T LH AV V +VE L G +
Sbjct: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870
Query: 275 ARDREGDTALHDAVRLNRYKIIKLL 299
++ TA+ D N KI++LL
Sbjct: 871 VLNKRQRTAV-DCAEQNS-KIMELL 893
Score = 71.2 bits (173), Expect = 1e-12
Identities = 45/142 (31%), Positives = 72/142 (50%), Gaps = 3/142 (2%)
Query: 178 DQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHG 237
D T LH A++ G +++ L+ GA V+ D T +H AC+ G+ V LL +
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYK 519
Query: 238 ADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE---INARDREGDTALHDAVRLNRYK 294
A V+D +TPLH+A G + V+ + +E ++ + +GDT LH A R
Sbjct: 520 ASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQG 579
Query: 295 IIKLLLLHGADMMTKNLAGKTP 316
+I+ LL +GA +N +TP
Sbjct: 580 VIETLLQNGASTEIQNRLKETP 601
Score = 62.4 bits (150), Expect = 6e-10
Identities = 40/137 (29%), Positives = 67/137 (48%), Gaps = 3/137 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AAV G+ +I+ ++ G + D T LH A +G+ + LL A+ + QD
Sbjct: 470 AAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNG 529
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADT---NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL 271
T +H AC GH + VK L + ++ ++ ++ TPLH+A R G ++E L G
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
Query: 272 EINARDREGDTALHDAV 288
++R +T L A+
Sbjct: 590 STEIQNRLKETPLKCAL 606
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/80 (40%), Positives = 42/80 (52%), Gaps = 6/80 (7%)
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
RD TPLHVA GQ +++ +S G +NA D G T LH A + Y+ + LLLLH
Sbjct: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQ-KGYQSVTLLLLH 517
Query: 303 ---GADMMTKNLAGKTPTDL 319
A++ N G TP L
Sbjct: 518 YKASAEVQDNN--GNTPLHL 535
Score = 45.8 bits (107), Expect = 6e-05
Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 3/115 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLD---NGATVDFQD 211
A +G V L SA+ D T LH A GH + ++ L+ +D +
Sbjct: 503 ACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGN 562
Query: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
T +H A R G+ V++ L +GA T ++++L TPL A+ + + ++E +
Sbjct: 563 EKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAY 617
Score = 29.6 bits (65), Expect = 4.4
Identities = 33/114 (28%), Positives = 44/114 (38%), Gaps = 18/114 (15%)
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLH--------VAVRTGQVEIVEH 265
DC H A G EV +LL D + K+ PL V+ R +V
Sbjct: 399 DCLFKHIAS-GNQKEVERLLSQEDHDKDTVQKMCH-PLCFCDDCEKLVSGRLNDPSVVTP 456
Query: 266 FLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
F +RD G T LH A + +I LL+ GA + + G TP L
Sbjct: 457 F--------SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHL 502
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 91.3 bits (225), Expect = 1e-18
Identities = 60/173 (34%), Positives = 86/173 (49%), Gaps = 1/173 (0%)
Query: 151 TFLKAAVE-GKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDF 209
T L AVE GK++ I+ L G D DQ LH A+ G I + LL GA+++
Sbjct: 529 TPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL 588
Query: 210 QDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSL 269
T +H A GHLE++ LL A+ + TPLH+A R G+ +V L
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648
Query: 270 GLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQL 322
G + NA ++ G T LH AV+ + + + LL H A++ +N G TP L L
Sbjct: 649 GADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
Score = 86.3 bits (212), Expect = 4e-17
Identities = 62/200 (31%), Positives = 88/200 (44%), Gaps = 33/200 (16%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L AA + + + LA G A+ D+ LH A+ G LLD+GA VD Q+R
Sbjct: 400 LIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 459
Query: 213 LDCTAMHWACRG---------------------------------GHLEVVKLLQSHGAD 239
T +H A + GH+ +VKLL S GA+
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519
Query: 240 TNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLL 299
+ + + L TPLH+AV G+V ++H L G +A D+ G LH A +Y I K+L
Sbjct: 520 LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKML 579
Query: 300 LLHGADMMTKNLAGKTPTDL 319
L +GA + G TP L
Sbjct: 580 LRYGASLELPTHQGWTPLHL 599
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/165 (30%), Positives = 79/165 (47%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA GK + + L G S + T LH A+ +GH+EI+ L ++ A + ++
Sbjct: 567 AAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN 626
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
T +H A R G VV L GAD N ++ TPLH+AV+ V + L ++
Sbjct: 627 WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
AR++ G T H A I+K+L+ GA + ++ TP L
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
Score = 66.6 bits (161), Expect = 3e-11
Identities = 52/190 (27%), Positives = 76/190 (40%), Gaps = 3/190 (1%)
Query: 130 LAASHEPPPEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRAS 189
L S + P E G AA G + +++ + G D + RT LH A
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHV---AAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535
Query: 190 LEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLST 249
G + ++ LL +GA D D+ +H A G + K+L +GA + T
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595
Query: 250 PLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTK 309
PLH+A G +EI+ + A T LH A R ++ LL GAD
Sbjct: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655
Query: 310 NLAGKTPTDL 319
+G TP L
Sbjct: 656 EQSGWTPLHL 665
Score = 62.0 bits (149), Expect = 8e-10
Identities = 44/134 (32%), Positives = 63/134 (47%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
T LH +G +E + LL + VD Q T + A + ++ LL +HGAD N
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
D+ PLH A + G L G ++A++REG T LH A + N + +LL+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 303 GADMMTKNLAGKTP 316
AD GKTP
Sbjct: 484 QADPNLHEAEGKTP 497
Score = 59.3 bits (142), Expect = 5e-09
Identities = 47/183 (25%), Positives = 80/183 (43%), Gaps = 1/183 (0%)
Query: 138 PEPEEITGPVDEETFLKAAV-EGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEI 196
P EE+ ++ T L V +G ++ + LA D T L A+ + ++
Sbjct: 351 PRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDL 410
Query: 197 LEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVR 256
LL +GA + D +H+A + G +LL HGA + +++ TPLH+A +
Sbjct: 411 CALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ 470
Query: 257 TGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ +S + N + EG T LH A ++KLL GA++ + +TP
Sbjct: 471 NNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP 530
Query: 317 TDL 319
L
Sbjct: 531 LHL 533
Score = 57.4 bits (137), Expect = 2e-08
Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 4/163 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA +G +++I + T LH A+ G ++ LL GA + ++
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 215 CTAMHWAC-RGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEI 273
T +H A R L V+ LL+ H A+ + R+K+ TP H+A G I++ + G ++
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHH-ANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718
Query: 274 NARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
+ +D T L A+R + I+ L G + L G P
Sbjct: 719 DVQDGVSCTPLQLALRSRKQGIMS--FLEGKEPSVATLGGSKP 759
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 90.5 bits (223), Expect = 2e-18
Identities = 50/154 (32%), Positives = 84/154 (54%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L AA G +++++ + G D D+ A++ A+ GH++ L+ L +N +D +D+
Sbjct: 384 LIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDK 443
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
A+H A R GH +V +LL S G++ N++DK TPLH A G + + G
Sbjct: 444 SGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCN 503
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
+N ++REG+T L A + I++ L HGAD+
Sbjct: 504 VNIKNREGETPLLTASARGYHDIVECLAEHGADL 537
Score = 85.9 bits (211), Expect = 5e-17
Identities = 43/125 (34%), Positives = 69/125 (55%)
Query: 192 GHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPL 251
G+++IL+ L+ G+ +D QD+ A++WA R GH++ +K L + +V+DK L
Sbjct: 390 GNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMAL 449
Query: 252 HVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNL 311
HVA R G ++ + S G N +D+E +T LH A Y + K L G ++ KN
Sbjct: 450 HVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNR 509
Query: 312 AGKTP 316
G+TP
Sbjct: 510 EGETP 514
Score = 82.4 bits (202), Expect = 6e-16
Identities = 46/152 (30%), Positives = 76/152 (50%), Gaps = 1/152 (0%)
Query: 149 EETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVD 208
E L A+ G ++E G + CD+ ALH A ME+++ LL G VD
Sbjct: 512 ETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD 571
Query: 209 FQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLS 268
+QDR T +H AC+ G++ +V L + ++ +K TPLH+A G +++V +
Sbjct: 572 YQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCL 631
Query: 269 LGLEINARDREGDTALHDAVRLNRYKIIKLLL 300
+G + A +G TA D R +++ + LL
Sbjct: 632 MGASVEALTTDGKTA-EDLARSEQHEHVAGLL 662
Score = 81.6 bits (200), Expect = 1e-15
Identities = 53/180 (29%), Positives = 87/180 (48%)
Query: 140 PEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEK 199
P ++ E AA G V + + G + + D+ T LH A+ G+ + +
Sbjct: 437 PLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKA 496
Query: 200 LLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQ 259
L + G V+ ++R T + A G+ ++V+ L HGAD N DK LH+AVR Q
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 260 VEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
+E+++ LS G ++ +DR G+T LH A + I+ L ++ N G+TP L
Sbjct: 557 MEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 616
Score = 75.9 bits (185), Expect = 5e-14
Identities = 54/175 (30%), Positives = 86/175 (49%), Gaps = 1/175 (0%)
Query: 148 DEETFLK-AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
+EET L AA G V + G + + ++ T L AS G+ +I+E L ++GA
Sbjct: 477 EEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGAD 536
Query: 207 VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHF 266
++ D+ A+H A R +EV+K L S G + +D+ +TPLHVA + G + IV
Sbjct: 537 LNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVAL 596
Query: 267 LSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQ 321
++ ++ G T LH A +++ L L GA + GKT DL +
Sbjct: 597 CEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLAR 651
Score = 30.0 bits (66), Expect = 3.4
Identities = 23/87 (26%), Positives = 38/87 (43%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A +G M ++ + D +++ RT LH A+ G ++++ L GA+V+
Sbjct: 584 ACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDG 643
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTN 241
TA A H V LL DT+
Sbjct: 644 KTAEDLARSEQHEHVAGLLARLRKDTH 670
>gi|17864094 feminization 1 homolog a [Homo sapiens]
Length = 617
Score = 88.6 bits (218), Expect = 8e-18
Identities = 62/190 (32%), Positives = 99/190 (52%), Gaps = 15/190 (7%)
Query: 141 EEITGPVDEET-----FLKAAVEGKMKVIEKFLAD-------GGSADTCDQFRRTA--LH 186
EE++ + E+T L AA G + ++E L GGS + + A L
Sbjct: 29 EEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLW 88
Query: 187 RASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKL 246
AS GH+++++ LL++GA+V+ + T + AC GHLE+VK L H AD V ++
Sbjct: 89 AASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRH 148
Query: 247 LSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
T L ++ G EI ++ L G ++N + +G+TALHD I+K+LL++ A
Sbjct: 149 GHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCA-K 207
Query: 307 MTKNLAGKTP 316
M K+ G TP
Sbjct: 208 MEKDGYGMTP 217
Score = 40.0 bits (92), Expect = 0.003
Identities = 21/69 (30%), Positives = 33/69 (47%)
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
C + C+ L+V +L GAD NVRD ++PLH+A +I+ + G +
Sbjct: 496 CVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFD 555
Query: 275 ARDREGDTA 283
A + TA
Sbjct: 556 ATNLHKQTA 564
Score = 37.4 bits (85), Expect = 0.021
Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 13/91 (14%)
Query: 243 RDKLLSTPLHVAV-------------RTGQVEIVEHFLSLGLEINARDREGDTALHDAVR 289
R K +PLH+AV + +++ + G ++N RD + ++ LH A
Sbjct: 478 RGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAAL 537
Query: 290 LNRYKIIKLLLLHGADMMTKNLAGKTPTDLV 320
N I+ LL+ GA NL +T +DL+
Sbjct: 538 NNHPDIMNLLIKSGAHFDATNLHKQTASDLL 568
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 88.2 bits (217), Expect = 1e-17
Identities = 60/165 (36%), Positives = 80/165 (48%), Gaps = 1/165 (0%)
Query: 156 AVEGKMKVI-EKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A GK++ + E LAD A DQ RTALH A GH EI+E LL G V+ +D
Sbjct: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
+ +H A G E+VK L GA N ++ TPLH A + EI L G +
Sbjct: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
A+D TA+H A K+I +LL + A ++ G TP L
Sbjct: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178
Score = 77.8 bits (190), Expect = 1e-14
Identities = 49/167 (29%), Positives = 81/167 (48%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A G +++E L G + D + LH A+ G EI++ LL GA V+ ++
Sbjct: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
CT +H+A E+ +L GA+ + +D +T +H A G ++++ L N
Sbjct: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQ 321
+D EG+T LH A R + KLL+ GA + +N KTP + +
Sbjct: 167 IQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
Score = 30.4 bits (67), Expect = 2.6
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 154 KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
+AA +G +K+I L S + D T LH A E +E + L+ GA++ +++
Sbjct: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
Query: 214 DCTAMHWACRGG 225
+ T + A +GG
Sbjct: 205 EKTPLQVA-KGG 215
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 86.3 bits (212), Expect = 4e-17
Identities = 55/169 (32%), Positives = 82/169 (48%), Gaps = 4/169 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++I L G TALH A++ GH+E + LL +GA V+ QD +
Sbjct: 108 AVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF 167
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG--LE 272
T +H A GH +V +LL GAD NV ++ PLH+A G + I + + G +
Sbjct: 168 FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 227
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMM--TKNLAGKTPTDL 319
+NA+D E LH R + I+K LL ++ N+ G TP L
Sbjct: 228 VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHL 276
Score = 78.6 bits (192), Expect = 8e-15
Identities = 43/122 (35%), Positives = 62/122 (50%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A + + E++ LL +GA + TA+H A GHLE +L HGA+ N+
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 162
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+D + TPLH+A G ++ L G ++N GD LH A I KLL+
Sbjct: 163 QDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEE 222
Query: 303 GA 304
G+
Sbjct: 223 GS 224
Score = 63.2 bits (152), Expect = 4e-10
Identities = 48/172 (27%), Positives = 84/172 (48%), Gaps = 8/172 (4%)
Query: 143 ITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTC--DQFRRTALHRASLEGHMEILEKL 200
++G V + A+ +G + + + + +G AD D LH S GH +I++ L
Sbjct: 195 VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYL 254
Query: 201 LDNGATVD--FQDRLDCTAMHWACRGGHLEVVK-LLQSHGADTNVRDKLLS-TPLHVAVR 256
L + V + T +H AC G EV K ++Q G ++ ++ + S T H A
Sbjct: 255 LQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT 314
Query: 257 TGQ-VEIVEHFLSLG-LEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
G+ +++V+ L + IN + R+G T LH A ++++ LL +GADM
Sbjct: 315 YGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM 366
Score = 44.7 bits (104), Expect = 1e-04
Identities = 29/92 (31%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQ--FRRTALHRASLEGH-MEILEKLLD-NGATVDFQ 210
A GK +V ++ + G+ + F TA H A G +++++ LLD N ++ Q
Sbjct: 277 ACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQ 336
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
R T +H AC GH+ +V+ L +GAD N+
Sbjct: 337 GRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 368
Score = 36.6 bits (83), Expect = 0.036
Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 1/100 (1%)
Query: 218 MHWACR-GGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINAR 276
+H C GG ++ L G + + T LH+AV E++ L G +I
Sbjct: 71 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQV 130
Query: 277 DREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G TALH A + +LL HGA++ ++ TP
Sbjct: 131 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTP 170
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 86.3 bits (212), Expect = 4e-17
Identities = 55/169 (32%), Positives = 82/169 (48%), Gaps = 4/169 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
A + ++I L G TALH A++ GH+E + LL +GA V+ QD +
Sbjct: 209 AVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF 268
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLG--LE 272
T +H A GH +V +LL GAD NV ++ PLH+A G + I + + G +
Sbjct: 269 FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 328
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMM--TKNLAGKTPTDL 319
+NA+D E LH R + I+K LL ++ N+ G TP L
Sbjct: 329 VNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHL 377
Score = 78.6 bits (192), Expect = 8e-15
Identities = 43/122 (35%), Positives = 62/122 (50%)
Query: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
TALH A + + E++ LL +GA + TA+H A GHLE +L HGA+ N+
Sbjct: 204 TALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNI 263
Query: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
+D + TPLH+A G ++ L G ++N GD LH A I KLL+
Sbjct: 264 QDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEE 323
Query: 303 GA 304
G+
Sbjct: 324 GS 325
Score = 63.2 bits (152), Expect = 4e-10
Identities = 48/172 (27%), Positives = 84/172 (48%), Gaps = 8/172 (4%)
Query: 143 ITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTC--DQFRRTALHRASLEGHMEILEKL 200
++G V + A+ +G + + + + +G AD D LH S GH +I++ L
Sbjct: 296 VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYL 355
Query: 201 LDNGATVD--FQDRLDCTAMHWACRGGHLEVVK-LLQSHGADTNVRDKLLS-TPLHVAVR 256
L + V + T +H AC G EV K ++Q G ++ ++ + S T H A
Sbjct: 356 LQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACT 415
Query: 257 TGQ-VEIVEHFLSLG-LEINARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
G+ +++V+ L + IN + R+G T LH A ++++ LL +GADM
Sbjct: 416 YGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM 467
Score = 44.7 bits (104), Expect = 1e-04
Identities = 29/92 (31%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQ--FRRTALHRASLEGH-MEILEKLLD-NGATVDFQ 210
A GK +V ++ + G+ + F TA H A G +++++ LLD N ++ Q
Sbjct: 378 ACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQ 437
Query: 211 DRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
R T +H AC GH+ +V+ L +GAD N+
Sbjct: 438 GRDGHTGLHSACYHGHIRLVQFLLDNGADMNL 469
Score = 36.6 bits (83), Expect = 0.036
Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 1/100 (1%)
Query: 218 MHWACR-GGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINAR 276
+H C GG ++ L G + + T LH+AV E++ L G +I
Sbjct: 172 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQV 231
Query: 277 DREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G TALH A + +LL HGA++ ++ TP
Sbjct: 232 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTP 271
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 85.9 bits (211), Expect = 5e-17
Identities = 53/170 (31%), Positives = 82/170 (48%), Gaps = 2/170 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G + ++ L + D D + T L RA GH ++++ L+ GA VD D+
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
+ +HWA GG+ +V ++L + + NV+D TPL A G + + + + N
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGA--DMMTKNLAGKTPTDLVQL 322
+D+EG TALH + IKLLL A + M N TP D L
Sbjct: 484 IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALL 533
Score = 73.2 bits (178), Expect = 3e-13
Identities = 58/191 (30%), Positives = 94/191 (49%), Gaps = 17/191 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSA--DTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
AAV G +++ + G SA D DQF RT L L ++ + LL GA V+ D
Sbjct: 21 AAVNGDKGALQRLIV-GNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDH 79
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQ---VEIVEHFLSL 269
TA+H A + G+ +KLL + A+ +D TPLH+ R + ++ F++
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAP 139
Query: 270 GLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRH 329
G E++ +D+ TALH + N + +KLL+ H +++ ++ GK P W A+
Sbjct: 140 G-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLH----WAAN--- 191
Query: 330 ALEHPEPGAEH 340
H +P A H
Sbjct: 192 ---HKDPSAVH 199
Score = 69.3 bits (168), Expect = 5e-12
Identities = 44/165 (26%), Positives = 78/165 (47%), Gaps = 2/165 (1%)
Query: 142 EITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLL 201
+ T + +A G VI+ + G D DQ + LH A+L G+ ++ + L+
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443
Query: 202 DNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVE 261
+N + QD T + A GG++ + +L + AD N++DK T LH + G ++
Sbjct: 444 ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLD 503
Query: 262 IVEHFLSLGLEIN--ARDREGDTALHDAVRLNRYKIIKLLLLHGA 304
++ L N + E T L A+ R+++I+ +L HGA
Sbjct: 504 AIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 65.9 bits (159), Expect = 6e-11
Identities = 42/164 (25%), Positives = 78/164 (47%), Gaps = 2/164 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ--DR 212
AA + ++ FL D D RT+ A+ +G ++L +L + +D D+
Sbjct: 296 AAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
TA+H A GH+ VKLL + A + D + TPL A G ++++ + G
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++ D++G + LH A + ++L+ + + ++ AG+TP
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459
Score = 61.2 bits (147), Expect = 1e-09
Identities = 47/166 (28%), Positives = 77/166 (46%), Gaps = 4/166 (2%)
Query: 155 AAVEGKMKVIEKFLA-DGGSADTCDQFRRTALHRASLEGHMEILEKLLD-NGATVDFQDR 212
A +G + V++ + + + + D RT LH A+L GH +I+ LL+ N + D
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSL--G 270
T +H+A + E VK+ H + + D T A G +++ LSL
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++IN D+ G TALH A +KLLL + A + ++ TP
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
Score = 48.5 bits (114), Expect = 9e-06
Identities = 55/200 (27%), Positives = 87/200 (43%), Gaps = 50/200 (25%)
Query: 161 MKVIEKFLADGGSADTCDQFRRTALHRASLEG---HMEILEK------------------ 199
+ ++ KF+A G DT D+ ++TALH ++ H+++L K
Sbjct: 130 LALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHW 188
Query: 200 ---------------LLDNGAT---VDFQDRLDCTAMHWACRGGHLEVVKLLQSH-GADT 240
+LD T +++QD T +H+A G++ VV +L S+ +
Sbjct: 189 AANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNI 248
Query: 241 NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN-----ARDREGDTALHDAVRLNRYKI 295
D L TPLH A G +IV H L LE N D +G T LH A + N +
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIV-HLL---LERNKSGTIPSDSQGATPLHYAAQSNFAET 304
Query: 296 IKLLLLHGADMMTKNLAGKT 315
+K+ L H + +L G+T
Sbjct: 305 VKVFLKHPSVKDDSDLEGRT 324
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 85.9 bits (211), Expect = 5e-17
Identities = 53/170 (31%), Positives = 82/170 (48%), Gaps = 2/170 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+ G + ++ L + D D + T L RA GH ++++ L+ GA VD D+
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
+ +HWA GG+ +V ++L + + NV+D TPL A G + + + + N
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGA--DMMTKNLAGKTPTDLVQL 322
+D+EG TALH + IKLLL A + M N TP D L
Sbjct: 484 IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALL 533
Score = 73.2 bits (178), Expect = 3e-13
Identities = 58/191 (30%), Positives = 94/191 (49%), Gaps = 17/191 (8%)
Query: 155 AAVEGKMKVIEKFLADGGSA--DTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
AAV G +++ + G SA D DQF RT L L ++ + LL GA V+ D
Sbjct: 21 AAVNGDKGALQRLIV-GNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDH 79
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQ---VEIVEHFLSL 269
TA+H A + G+ +KLL + A+ +D TPLH+ R + ++ F++
Sbjct: 80 SQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAP 139
Query: 270 GLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRH 329
G E++ +D+ TALH + N + +KLL+ H +++ ++ GK P W A+
Sbjct: 140 G-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLH----WAAN--- 191
Query: 330 ALEHPEPGAEH 340
H +P A H
Sbjct: 192 ---HKDPSAVH 199
Score = 69.3 bits (168), Expect = 5e-12
Identities = 44/165 (26%), Positives = 78/165 (47%), Gaps = 2/165 (1%)
Query: 142 EITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLL 201
+ T + +A G VI+ + G D DQ + LH A+L G+ ++ + L+
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443
Query: 202 DNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVE 261
+N + QD T + A GG++ + +L + AD N++DK T LH + G ++
Sbjct: 444 ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLD 503
Query: 262 IVEHFLSLGLEIN--ARDREGDTALHDAVRLNRYKIIKLLLLHGA 304
++ L N + E T L A+ R+++I+ +L HGA
Sbjct: 504 AIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 65.9 bits (159), Expect = 6e-11
Identities = 42/164 (25%), Positives = 78/164 (47%), Gaps = 2/164 (1%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQ--DR 212
AA + ++ FL D D RT+ A+ +G ++L +L + +D D+
Sbjct: 296 AAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
TA+H A GH+ VKLL + A + D + TPL A G ++++ + G
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++ D++G + LH A + ++L+ + + ++ AG+TP
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459
Score = 61.2 bits (147), Expect = 1e-09
Identities = 47/166 (28%), Positives = 77/166 (46%), Gaps = 4/166 (2%)
Query: 155 AAVEGKMKVIEKFLA-DGGSADTCDQFRRTALHRASLEGHMEILEKLLD-NGATVDFQDR 212
A +G + V++ + + + + D RT LH A+L GH +I+ LL+ N + D
Sbjct: 228 AVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDS 287
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSL--G 270
T +H+A + E VK+ H + + D T A G +++ LSL
Sbjct: 288 QGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSD 347
Query: 271 LEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
++IN D+ G TALH A +KLLL + A + ++ TP
Sbjct: 348 IDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTP 393
Score = 48.5 bits (114), Expect = 9e-06
Identities = 55/200 (27%), Positives = 87/200 (43%), Gaps = 50/200 (25%)
Query: 161 MKVIEKFLADGGSADTCDQFRRTALHRASLEG---HMEILEK------------------ 199
+ ++ KF+A G DT D+ ++TALH ++ H+++L K
Sbjct: 130 LALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHW 188
Query: 200 ---------------LLDNGAT---VDFQDRLDCTAMHWACRGGHLEVVKLLQSH-GADT 240
+LD T +++QD T +H+A G++ VV +L S+ +
Sbjct: 189 AANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNI 248
Query: 241 NVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN-----ARDREGDTALHDAVRLNRYKI 295
D L TPLH A G +IV H L LE N D +G T LH A + N +
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIV-HLL---LERNKSGTIPSDSQGATPLHYAAQSNFAET 304
Query: 296 IKLLLLHGADMMTKNLAGKT 315
+K+ L H + +L G+T
Sbjct: 305 VKVFLKHPSVKDDSDLEGRT 324
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 85.9 bits (211), Expect = 5e-17
Identities = 50/161 (31%), Positives = 84/161 (52%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA+EG ++E + G + D R L+ +LE + + E L+NGA V+ D
Sbjct: 920 AALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEG 979
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+H +C GH+E+V++L ++ AD N D + L A G V++V+ + G ++
Sbjct: 980 RTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD 1039
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
+G TAL A + ++++LL HGAD + G+T
Sbjct: 1040 HTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1080
Score = 84.3 bits (207), Expect = 2e-16
Identities = 51/152 (33%), Positives = 85/152 (55%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A+E ++ + E FL +G + + D RTALH + +GHME+++ L+ A V+ D
Sbjct: 954 ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINA 275
+A+ A GH++VV+LL HGA + +T L +A + G +++V+ L G + N
Sbjct: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073
Query: 276 RDREGDTALHDAVRLNRYKIIKLLLLHGADMM 307
D+ G TA+ A + +IIKLL +GA +
Sbjct: 1074 ADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105
Score = 84.0 bits (206), Expect = 2e-16
Identities = 53/168 (31%), Positives = 83/168 (49%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G + V+ ++ G + D T L A+ +GH +++ L+ GA ++ D+
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
TA+ A GGH EVV L G + D T L A G +IV + L G E+N
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQL 322
D EG TAL A + +I++ LL HGA++ +++ G+T + L
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAAL 719
Score = 83.6 bits (205), Expect = 3e-16
Identities = 59/174 (33%), Positives = 85/174 (48%), Gaps = 6/174 (3%)
Query: 148 DEETFLKAAVEGKMK-VIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGAT 206
D T L+AA G + ++ L G + D RTAL A+ GH EI+E LLD+GA
Sbjct: 643 DSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE 702
Query: 207 VDFQD-----RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVE 261
V+ +D L A+ GH VV LL GA+ + DK TPL VA G V+
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762
Query: 262 IVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKT 315
+V+ L G +++ D G T L A + ++ LL GA + + + G+T
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRT 816
Score = 83.2 bits (204), Expect = 3e-16
Identities = 48/152 (31%), Positives = 78/152 (51%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA EG + E + G + D R AS EGH + ++ LL+N + +D +
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDG 913
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN 274
A+ A GH ++V+LL SHGAD N +D L++ Q+ + E+FL G +
Sbjct: 914 RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVE 973
Query: 275 ARDREGDTALHDAVRLNRYKIIKLLLLHGADM 306
A D EG TALH + +++++L+ + AD+
Sbjct: 974 ASDAEGRTALHVSCWQGHMEMVQVLIAYHADV 1005
Score = 77.4 bits (189), Expect = 2e-14
Identities = 61/193 (31%), Positives = 84/193 (43%), Gaps = 1/193 (0%)
Query: 156 AVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDC 215
A +G V+ + G D CD+ T L A+ EGH+++++ LL+ GA VD D
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 216 TAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINA 275
T + A GH VV L GA + D T L +A G VE+V L GL+ N
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 276 RDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLV-QLWQADTRHALEHP 334
RD G T LH A I + L+ GA + G+ P L Q D L
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
Query: 335 EPGAEHNGLEGPN 347
+ + G +G N
Sbjct: 903 KSNIDQRGYDGRN 915
Score = 77.0 bits (188), Expect = 2e-14
Identities = 57/167 (34%), Positives = 79/167 (47%), Gaps = 5/167 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
AA G +V+ L G D D RTAL A+ GH +I+ LL +GA V+ D
Sbjct: 618 AAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEG 677
Query: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAV-----RTGQVEIVEHFLSL 269
TA+ A GH E+V+ L HGA+ N D T L VA G +V +
Sbjct: 678 RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
Query: 270 GLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
G E++ D++G T L A ++ LLL GAD+ + G+TP
Sbjct: 738 GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTP 784
Score = 77.0 bits (188), Expect = 2e-14
Identities = 52/162 (32%), Positives = 76/162 (46%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L AA G V+ L G + D+ D RT L AS +G++E++ LLD G + +D
Sbjct: 786 LAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 845
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
T +H A GH + + L GA TN D P +A + G + V+ L
Sbjct: 846 AGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSN 905
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGK 314
I+ R +G AL A I++LL HGAD+ K+ G+
Sbjct: 906 IDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGR 947
Score = 76.6 bits (187), Expect = 3e-14
Identities = 56/179 (31%), Positives = 85/179 (47%), Gaps = 3/179 (1%)
Query: 164 IEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACR 223
I L +G S + CD RT L A+ G ++++ L+ GA ++ +D T + A R
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 224 GGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTA 283
GH +VV L GA+ N D+ T L A G E+V L G++++ D + TA
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTA 647
Query: 284 LHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHALEH-PEPGAEHN 341
L A I+ LL HGA++ + G+T L+ R +EH + GAE N
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTA--LIAAAYMGHREIVEHLLDHGAEVN 704
Score = 74.3 bits (181), Expect = 2e-13
Identities = 52/162 (32%), Positives = 75/162 (46%)
Query: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
L AA EG + V++ L G D D RT L A+ GH ++ LL GA VD D
Sbjct: 753 LVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS 812
Query: 213 LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE 272
T + A G++EVV+ L G D N RD TPLH+A G I E + G
Sbjct: 813 EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 872
Query: 273 INARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGK 314
N D +G A + Y +++LL + +++ + G+
Sbjct: 873 TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGR 914
Score = 63.2 bits (152), Expect = 4e-10
Identities = 40/136 (29%), Positives = 74/136 (54%), Gaps = 4/136 (2%)
Query: 155 AAVEGKMKVIEKFLADGGSAD-TCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRL 213
AA +G +KV++ + G D TC+Q TAL A+ EGH+++++ LL++GA + D+
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQ-GATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
Query: 214 DCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEI 273
TAM A + GH +++KLL+ +GA + + +P+H + + SL ++
Sbjct: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASS--LNGCSPSPVHTMEQKPLQSLSSKVQSLTIKS 1135
Query: 274 NARDREGDTALHDAVR 289
N+ G + ++R
Sbjct: 1136 NSSGSTGGGDMQPSLR 1151
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,513,068
Number of Sequences: 37866
Number of extensions: 665888
Number of successful extensions: 5598
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 366
Number of HSP's successfully gapped in prelim test: 113
Number of HSP's that attempted gapping in prelim test: 2380
Number of HSP's gapped (non-prelim): 2025
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.