Guide to the Human Genome
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Search of human proteins with 39753961

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39753961 IQ motif containing GTPase activating protein 3
[Homo sapiens]
         (1631 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39753961 IQ motif containing GTPase activating protein 3 [Hom...  3200   0.0  
gi|4506787 IQ motif containing GTPase activating protein 1 [Homo...  1916   0.0  
gi|116089337 IQ motif containing GTPase activating protein 2 [Ho...  1232   0.0  
gi|4557793 neurofibromin isoform 2 [Homo sapiens]                      68   8e-11
gi|109826564 neurofibromin isoform 1 [Homo sapiens]                    59   3e-08
gi|126116596 asp (abnormal spindle)-like, microcephaly associate...    55   7e-07
gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo s...    51   8e-06
gi|153945715 myosin VC [Homo sapiens]                                  48   7e-05
gi|4759026 RAS protein activator like 1 [Homo sapiens]                 46   3e-04
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]        45   8e-04
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]       45   8e-04
gi|222831628 IQ motif containing F5 [Homo sapiens]                     42   0.005
gi|38201692 RAS p21 protein activator 3 [Homo sapiens]                 41   0.008
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho...    40   0.024
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho...    40   0.024
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]       39   0.032
gi|215982794 myosin VA isoform 2 [Homo sapiens]                        39   0.041
gi|215982791 myosin VA isoform 1 [Homo sapiens]                        39   0.041
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     39   0.054
gi|4507357 transgelin 2 [Homo sapiens]                                 39   0.054
gi|122937512 myosin VIIB [Homo sapiens]                                39   0.054
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]     38   0.070
gi|5454102 transforming, acidic coiled-coil containing protein 3...    38   0.070
gi|224451032 KIAA1683 isoform a [Homo sapiens]                         38   0.092
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             38   0.092
gi|224451036 KIAA1683 isoform c [Homo sapiens]                         38   0.092
gi|54606862 KIAA1683 isoform b [Homo sapiens]                          38   0.092
gi|28269672 serologically defined colon cancer antigen 8 [Homo s...    38   0.092
gi|156119615 myosin IXA [Homo sapiens]                                 37   0.12 
gi|189083802 myosin VIIA isoform 2 [Homo sapiens]                      37   0.12 

>gi|39753961 IQ motif containing GTPase activating protein 3 [Homo
            sapiens]
          Length = 1631

 Score = 3200 bits (8298), Expect = 0.0
 Identities = 1631/1631 (100%), Positives = 1631/1631 (100%)

Query: 1    MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEE 60
            MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEE
Sbjct: 1    MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEE 60

Query: 61   SLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPS 120
            SLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPS
Sbjct: 61   SLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPS 120

Query: 121  TFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELA 180
            TFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELA
Sbjct: 121  TFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELA 180

Query: 181  KYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENL 240
            KYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENL
Sbjct: 181  KYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENL 240

Query: 241  REPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVV 300
            REPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVV
Sbjct: 241  REPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVV 300

Query: 301  DDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEV 360
            DDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEV
Sbjct: 301  DDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEV 360

Query: 361  QAGVAAANTKGDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQL 420
            QAGVAAANTKGDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQL
Sbjct: 361  QAGVAAANTKGDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQL 420

Query: 421  ELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGEN 480
            ELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGEN
Sbjct: 421  ELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGEN 480

Query: 481  AQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSP 540
            AQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSP
Sbjct: 481  AQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSP 540

Query: 541  EKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRAN 600
            EKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRAN
Sbjct: 541  EKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRAN 600

Query: 601  QDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAK 660
            QDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAK
Sbjct: 601  QDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAK 660

Query: 661  KQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAA 720
            KQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAA
Sbjct: 661  KQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAA 720

Query: 721  YDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY 780
            YDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY
Sbjct: 721  YDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY 780

Query: 781  LEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY 840
            LEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY
Sbjct: 781  LEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY 840

Query: 841  RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDI 900
            RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDI
Sbjct: 841  RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDI 900

Query: 901  KIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLF 960
            KIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLF
Sbjct: 901  KIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLF 960

Query: 961  YLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKS 1020
            YLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKS
Sbjct: 961  YLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKS 1020

Query: 1021 KVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYK 1080
            KVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYK
Sbjct: 1021 KVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYK 1080

Query: 1081 NWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQI 1140
            NWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQI
Sbjct: 1081 NWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQI 1140

Query: 1141 PYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGA 1200
            PYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGA
Sbjct: 1141 PYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGA 1200

Query: 1201 LAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPE 1260
            LAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPE
Sbjct: 1201 LAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPE 1260

Query: 1261 ERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPT 1320
            ERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPT
Sbjct: 1261 ERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPT 1320

Query: 1321 IPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFH 1380
            IPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFH
Sbjct: 1321 IPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFH 1380

Query: 1381 PGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRV 1440
            PGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRV
Sbjct: 1381 PGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRV 1440

Query: 1441 LRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTF 1500
            LRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTF
Sbjct: 1441 LRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTF 1500

Query: 1501 YEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFR 1560
            YEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFR
Sbjct: 1501 YEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFR 1560

Query: 1561 NVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLL 1620
            NVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLL
Sbjct: 1561 NVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLL 1620

Query: 1621 IFLLNKKFLRK 1631
            IFLLNKKFLRK
Sbjct: 1621 IFLLNKKFLRK 1631


>gi|4506787 IQ motif containing GTPase activating protein 1 [Homo
            sapiens]
          Length = 1657

 Score = 1916 bits (4964), Expect = 0.0
 Identities = 970/1635 (59%), Positives = 1250/1635 (76%), Gaps = 18/1635 (1%)

Query: 14   ERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGH 73
            ERLTAEEMDE+RRQNVAY+YLC LEEAKRWMEACL E+LP   ELEE LRNGV LAKLG+
Sbjct: 24   ERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGN 83

Query: 74   CFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKK 133
             F+P VV LKKIYD EQ RY+ATGLHFRHTDN+  WL+A+  IGLP  F+PETTDIYD+K
Sbjct: 84   FFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRK 143

Query: 134  NMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIG 193
            NMPR +YCIHALSL+LF+LGLAPQI DLYGKV FT EE++NM +EL KYG+Q+PAFSKIG
Sbjct: 144  NMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIG 203

Query: 194  GILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLA 253
            GILANELSVDEAA+HAAV+AINEA++R +  DT AAL+NP+A+L NL EPLA+ YQ++L 
Sbjct: 204  GILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILY 263

Query: 254  QAKMEKAANARNHDDRESQ--DIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPEA 311
            QAK +K  NA+N  +   +  D+Y+  LTQAEIQGNIN VN   AL  +D ALE+    A
Sbjct: 264  QAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALA 323

Query: 312  LLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTKG 371
            L +ALQ PAL LRG+++  +DWYL+QL SD++QK Q  G  + L+KEE+Q+GV AAN+  
Sbjct: 324  LFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS-GQTDPLQKEELQSGVDAANSAA 382

Query: 372  DQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQGE 431
             Q Q  L AV  IN AI++GVA  TV ELM PEAQLP VYP A+ +YQ ELA LQ+Q  E
Sbjct: 383  QQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPE 442

Query: 432  --LGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALL 489
              L   EL VAVEMLS+V LINRALE+ D +  W  L +  TGL  +E EN QRY D L+
Sbjct: 443  HNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELM 502

Query: 490  KLR-QERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALL 548
            KL+ Q      +F++WND+QA V  VN   QEE +R+LA+ LINEALD+G  +KTL AL 
Sbjct: 503  KLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQ 562

Query: 549  LPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQR 608
            +PAA L+ V   VA  Y   L+ AKR+KAQ   D  AVLWL+EI+ G+ ++N+DT  AQ+
Sbjct: 563  IPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQK 622

Query: 609  MALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAKKQRPADT- 667
             ALG+ AIN+A++ G   +T   LR+P V L GV+P+C   Y   L  A  KK    D  
Sbjct: 623  FALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNN 682

Query: 668  AFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLW 727
            + WV+H +K G  YY +L+T +G W++PP    N+  L+REEIQS+++ VTAAY+R+QLW
Sbjct: 683  SKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLW 742

Query: 728  KANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYF 787
             AN G + +LQAR RG+LVRQ+F    +FL+  +PA+  IQ+ WRGY+Q+K Y + L Y 
Sbjct: 743  LANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYL 802

Query: 788  KANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAP 847
            +++ D ++KIQ+ ARM  AR++Y  RL YF+ ++N I+KIQAF RA KA+DDY+ L++A 
Sbjct: 803  RSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAE 862

Query: 848  HPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVK 907
             PP+ VVR+F HLL+QS QDF  E +L+K++EEV+  IRSNQQLE DLN+MDIKIGLLVK
Sbjct: 863  DPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVK 922

Query: 908  NRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKG-LKSLSKEKRQKLEAYQHLFYLLQTQ 966
            N+ITLQ+VVSH KKLTK+NKEQLSDMM+++KQKG LK+LSKEKR+KLEAYQHLFYLLQT 
Sbjct: 923  NKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTN 982

Query: 967  PIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQ 1026
            P YLAKLIFQMPQNK+TKFM++VIF+LYNYAS++RE YLLL+LFKTALQEEIKSKV+Q Q
Sbjct: 983  PTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQ 1042

Query: 1027 DVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQT 1086
            ++VTGNPTV+++VV F R  RGQ+AL++IL  V++++++DK L++ TDPV +YK+W+NQ 
Sbjct: 1043 EIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQM 1102

Query: 1087 EAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRY 1146
            E+QTG+ S LPYDVTPEQAL+H EV+ RLD ++RN+ A+TDKFL AI SSVD+IPYGMR+
Sbjct: 1103 ESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRF 1162

Query: 1147 VAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQR 1206
            +AKVLK +L EKFPDA + E+ K++GNLLYYR++NPA+VAPDAFDI+ ++AGG L   QR
Sbjct: 1163 IAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQR 1222

Query: 1207 HALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVD 1266
              LG++A++LQHAA+ K F G + HL ++N+YL +++ KFR+F   AC VPE +++F VD
Sbjct: 1223 RNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVD 1282

Query: 1267 EYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIG 1326
            EYSD+V + KP++YI++GE++NTH LLL+HQD IAP+H DP+HELL+DLGE+PTI  LIG
Sbjct: 1283 EYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIG 1342

Query: 1327 ES---IAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGD 1383
            ES   +       L+K EVSLTLTNKF+    +  + + R++LL+TK+L+ D+I+F PG+
Sbjct: 1343 ESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGE 1402

Query: 1384 TLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRN 1443
            TL EIL   A+ EQEA H++ M RR    A+TP+ +++ +S+   S L L EK+ ++   
Sbjct: 1403 TLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTG 1462

Query: 1444 LRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEE 1503
            L++L  LG V  +N YQ L++++A+DIRNQ R+R RRKAELVKLQ T   L++K TFY E
Sbjct: 1463 LKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGE 1522

Query: 1504 QGDYYSQYIRACLDHLAPDSKSS-------GKGKKQPSLHYTAAQLLEKGVLVEIEDLPA 1556
            Q DYY  YI+ CLD+LA   K S       GK  K+ SL YTAA+L EKGVL+EIEDL  
Sbjct: 1523 QVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQV 1582

Query: 1557 SHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVN 1616
            + F+NVIF+I+P +E G FEV AKF+GV ME F LHYQDLLQLQYEGVAVMKLF++AKVN
Sbjct: 1583 NQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVN 1642

Query: 1617 VNLLIFLLNKKFLRK 1631
            VNLLIFLLNKKF  K
Sbjct: 1643 VNLLIFLLNKKFYGK 1657


>gi|116089337 IQ motif containing GTPase activating protein 2 [Homo
            sapiens]
          Length = 1575

 Score = 1232 bits (3187), Expect = 0.0
 Identities = 656/1379 (47%), Positives = 925/1379 (67%), Gaps = 45/1379 (3%)

Query: 287  NINHVNVHGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKA 346
            +++   +H A+  +++A+E+   E  +  L++P   L  V  + A  Y ++L   +++K 
Sbjct: 208  SVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKE 267

Query: 347  QELGLV-------------ELLEKEEVQAGVAAANTKGDQEQAMLHAVQRINKAIRRGVA 393
            +   L              ELL + E+Q  +   N +         AV  IN  I  G  
Sbjct: 268  ENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQA--------AVDHINAVIPEGDP 319

Query: 394  ADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQ--GELGQEELFVAVEMLSAVVLIN 451
             +T+  L  PEAQLP VYP A++MYQ EL  LQ+Q     L  EEL +AVEMLSAV L+N
Sbjct: 320  ENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLN 379

Query: 452  RALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALLKLRQE-RGMGEDFLSWNDLQAT 510
            +ALE+ D     + L +PA GL  ++    +RY + LL ++ E    G+D LSWN++Q  
Sbjct: 380  QALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNC 439

Query: 511  VSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYHLLLV 570
            +  VNAQ QEE DRV+AV  INEA+D+G+P +TL  LLLP A + DV    A  Y  +L 
Sbjct: 440  IDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLY 499

Query: 571  AAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQRMALGVAAINQAIKEGKAAQTER 630
             AK QK   +     VLWL+EI+Q V  AN D + A++    V  +NQ ++  K++    
Sbjct: 500  HAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVDVNQCLEGKKSSDILS 559

Query: 631  VLRNPAVALRGVVPDCANGYQRALESAMA-KKQRPADTAFWVQHDMKDGTAYYFHLQTFQ 689
            VL++       ++P+CA+ Y  AL  A   K +R +    W++ ++     YY++  + +
Sbjct: 560  VLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKE 619

Query: 690  GIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQK 749
              W  P  C    S LT +EI+  + +VT  Y R+ +W A+   +++ QA   G ++R++
Sbjct: 620  SSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREE 679

Query: 750  FAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQ 809
            F     FL      V+KIQA W+GY+QRK Y+   Q F  N D+I+KIQ+W RM  AR+ 
Sbjct: 680  FEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKS 739

Query: 810  YLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFL 869
            YL RL YF+ + N IVKIQ+  RA KA+DDY+ LV + +PPL+V+R+F +LL+QS  DF 
Sbjct: 740  YLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQ 799

Query: 870  AEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQ 929
             E E+ +L+EEVV KIR+NQQLE+DLN+MDIKIGLLVKNRITL++V+SH KKL K+   +
Sbjct: 800  EELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGE 859

Query: 930  LSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEAV 989
            +  +   D Q G+KSLSKE+R+ LE YQ LFYLLQT P+YLAKLIFQMPQNK+TKFM+ V
Sbjct: 860  MEILNNTDNQ-GIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTV 918

Query: 990  IFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQ 1049
            IF+LYNYAS++RE YLLL+LFKTAL+EEIKSKV+Q QD+VTGNPTV+++VV F R  RGQ
Sbjct: 919  IFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQ 978

Query: 1050 SALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHP 1109
            + L+++L  V++++++DK L ++T+PV +YK W+NQ E QTG+ S LPYDVT EQAL++P
Sbjct: 979  NTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYP 1038

Query: 1110 EVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYK 1169
            EV+ +L+ ++ NL  +TDK L +I SS+D +PYG+RY+AKVLK ++ EKFPDAT+ E+ K
Sbjct: 1039 EVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLK 1098

Query: 1170 VVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQS 1229
            +VGNLLYYR++NPA+VAPD FDI+ M AGG + + QR  LG+VA++LQHAA+ K F G++
Sbjct: 1099 IVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGEN 1158

Query: 1230 QHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVGELVNT 1289
            +HL  +N+YL ET+ +FRK+   AC VPEPEE+F +D+Y+D+V V+KP++YI++ E+++T
Sbjct: 1159 EHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIIST 1218

Query: 1290 HRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIA-------ADGHTDLSKLEV 1342
            H LLLEHQD IAP+  D L ELL  LGE+PT+   +GE          A+  + LSK E+
Sbjct: 1219 HSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEI 1278

Query: 1343 SLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGDTLKEILSLSASREQEAAHK 1402
            SL LT+K++  + +A DS  RSL++ TK+L+ D+I+  PG+TL EIL   A+ +QE  H 
Sbjct: 1279 SLVLTSKYDIEDGEAIDS--RSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHA 1336

Query: 1403 QLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRNLRRLEALGLVSARNGYQGL 1462
              M  R    ++TPE ++  +S+   + LPL +K+R++ RNLR LE  G VS+ N YQ +
Sbjct: 1337 TDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDI 1396

Query: 1463 VDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPD 1522
            ++E+AKDIRNQ  +R  RKAEL KLQ TL  L+ K  FYEEQ +YY  YI+ CLD+L   
Sbjct: 1397 LNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRK 1456

Query: 1523 S-----KSSGKG-----KKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEA 1572
            +     K  GKG     K+   + YTAA+L EKGVL++I+DL  + F+NV FDI   ++ 
Sbjct: 1457 NTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDV 1516

Query: 1573 GKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLLIFLLNKKFLRK 1631
            G F+V +KFLGV+ME+ QL+ QDLLQ+QYEGVAVMK+F+K KVNVNLLI+LLNKKF  K
Sbjct: 1517 GIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK 1575



 Score =  433 bits (1113), Expect = e-121
 Identities = 259/600 (43%), Positives = 351/600 (58%), Gaps = 41/600 (6%)

Query: 14  ERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGH 73
           ERL+AEEMDE+RRQN+AY+YLC LEEAKRWME CL EELP   ELEE LRNGV LAKL  
Sbjct: 21  ERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAK 80

Query: 74  CFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKK 133
            FAP +V  KKIYDVEQ RY+ +GLHFRHTDN   WL A+  IGLP  F+PETTD+YD+K
Sbjct: 81  FFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRK 140

Query: 134 NMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIG 193
           N+PR++YCIHALSL+LF+LG+APQI DL GKV FT EE+SNM  EL KYG+Q+P+FSKIG
Sbjct: 141 NIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIG 200

Query: 194 GILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLA 253
           GILANELSVDEAA+HAAV+AINEAVE+G+ E T+  L+NP+A+L  + + LA  YQ+ L 
Sbjct: 201 GILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELW 260

Query: 254 QAKMEKAANARNHD---DRESQDIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPE 310
            AK +K  NAR  +     E +D Y+  LTQAEIQGNIN VN   A++ ++  +    PE
Sbjct: 261 DAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPE 320

Query: 311 ALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTK 370
             L AL+ P   L  V    A  Y  +L + ++Q       +  L  EE+   V      
Sbjct: 321 NTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNT-----MNYLAHEELLIAV------ 369

Query: 371 GDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQL-----PPVYPVASSMYQLELAVL 425
                 ML AV  +N+A+          +L  P   L       V   A+++  ++L VL
Sbjct: 370 -----EMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVL 424

Query: 426 QQQQGELGQEELFVAVEMLS-----------AVVLINRALEARDASGFWSSLVNPATGLA 474
            Q Q  L   E+   ++M++           AV  IN A++  +      +L+ P   ++
Sbjct: 425 SQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANIS 484

Query: 475 EVEGENAQRYFDALLKLRQERGMGEDFLS---W-NDLQATVSQVNAQTQEETDRVLAVSL 530
           +V+  +AQ Y D L   + ++    + +S   W +++Q  V   N         V  V  
Sbjct: 485 DVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVD 544

Query: 531 INEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLE 590
           +N+ L+       LS L    +  +D+    A +Y+  LV AK  K++     G+  WL+
Sbjct: 545 VNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGS--WLK 602



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 26/71 (36%), Positives = 37/71 (52%)

Query: 595 GVVRANQDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRAL 654
           G + AN+ +     +   V AIN+A+++G A QT   LRNP   L  V  + A  YQ+ L
Sbjct: 200 GGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKEL 259

Query: 655 ESAMAKKQRPA 665
             A  KK+  A
Sbjct: 260 WDAKKKKEENA 270


>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
          Length = 2818

 Score = 67.8 bits (164), Expect = 8e-11
 Identities = 72/300 (24%), Positives = 131/300 (43%), Gaps = 56/300 (18%)

Query: 1004 YLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDV 1063
            +LL QL      +E++   +  Q +  GN ++   ++ F     G + LQ++L  +++ V
Sbjct: 1251 HLLYQLLWNMFSKEVEL-ADSMQTLFRGN-SLASKIMTFCFKVYGATYLQKLLDPLLRIV 1308

Query: 1064 LEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLL 1123
            +                +W            H+ ++V P +     E    L+   RNLL
Sbjct: 1309 ITSS-------------DW-----------QHVSFEVDPTRL----EPSESLEENQRNLL 1340

Query: 1124 AMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPA 1183
             MT+KF  AI SS  + P  +R V   L   ++++FP  +       VG+ ++ RF+NPA
Sbjct: 1341 QMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS----IGAVGSAMFLRFINPA 1396

Query: 1184 VVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETH 1243
            +V+P    I+       +       L  ++++LQ  A    F+ + +H+R  ND+++   
Sbjct: 1397 IVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFT-KEEHMRPFNDFVKSNF 1451

Query: 1244 LKFRKFIHRACQVPEPEERFAVDEYSDMV---AVAKPMVYITVGELVNTHRLLLEHQDCI 1300
                          +   RF +D  SD     AV   + +I+ G ++  HRLL  +Q+ I
Sbjct: 1452 --------------DAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKI 1497


>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
          Length = 2839

 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 75/317 (23%), Positives = 131/317 (41%), Gaps = 69/317 (21%)

Query: 1004 YLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDV 1063
            +LL QL      +E++   +  Q +  GN ++   ++ F     G + LQ++L  +++ V
Sbjct: 1251 HLLYQLLWNMFSKEVEL-ADSMQTLFRGN-SLASKIMTFCFKVYGATYLQKLLDPLLRIV 1308

Query: 1064 LEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLL 1123
            +                +W            H+ ++V P +     E    L+   RNLL
Sbjct: 1309 ITSS-------------DW-----------QHVSFEVDPTRL----EPSESLEENQRNLL 1340

Query: 1124 AMTDKFLLAITSSVDQIPYGMRYVAKVL----------KATLAEKFPDATD-------SE 1166
             MT+KF  AI SS  + P  +R V   L          KAT+ EK  +            
Sbjct: 1341 QMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQN 1400

Query: 1167 VYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFS 1226
                VG+ ++ RF+NPA+V+P    I+       +       L  ++++LQ  A    F+
Sbjct: 1401 SIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFT 1456

Query: 1227 GQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMV---AVAKPMVYITV 1283
             + +H+R  ND+++                 +   RF +D  SD     AV   + +I+ 
Sbjct: 1457 -KEEHMRPFNDFVKSNF--------------DAARRFFLDIASDCPTSDAVNHSLSFISD 1501

Query: 1284 GELVNTHRLLLEHQDCI 1300
            G ++  HRLL  +Q+ I
Sbjct: 1502 GNVLALHRLLWNNQEKI 1518


>gi|126116596 asp (abnormal spindle)-like, microcephaly associated
            [Homo sapiens]
          Length = 3477

 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 34/102 (33%), Positives = 53/102 (51%), Gaps = 15/102 (14%)

Query: 710  IQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQA 769
            +Q+      +A  ++Q++      VI +QAR +GF+ ++KF E  +       + IKIQA
Sbjct: 2889 LQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKN-------STIKIQA 2941

Query: 770  HWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYL 811
             WR YR +K        +   + A  KIQAW R W A ++YL
Sbjct: 2942 MWRRYRAKK--------YLCKVKAACKIQAWYRCWRAHKEYL 2975



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 42/137 (30%), Positives = 69/137 (50%), Gaps = 20/137 (14%)

Query: 709  EIQSAVTKVTAAYDR---QQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVI 765
            +++ A T + AAY     +QL K      +++Q+  RG+  R K+       ++ L ++I
Sbjct: 1800 QVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKY-------QSVLQSII 1852

Query: 766  KIQAHWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIV 825
            KIQ   R YR  K   +   +F     A+I +Q+  R W  R+Q +RR H       + +
Sbjct: 1853 KIQ---RWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQ-IRREH------QAAL 1902

Query: 826  KIQAFFRARKAQDDYRI 842
            KIQ+ FR  KAQ  +R+
Sbjct: 1903 KIQSAFRMAKAQKQFRL 1919



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 65/281 (23%), Positives = 109/281 (38%), Gaps = 81/281 (28%)

Query: 753  HSHFLRTWLP-AVIKIQAHWRGYRQRKIYL---------------------EWLQYFKAN 790
            H HFL      A   IQAH+RGY+ R+++L                     E ++Y +  
Sbjct: 3021 HEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKHERIKYIEFK 3080

Query: 791  LDAIIKIQAWARMWAARRQYL------RRLHY-------------------------FQK 819
               +I +QA  R W  R+++L      R LH+                           K
Sbjct: 3081 KSTVI-LQALVRGWLVRKRFLEQRAKIRLLHFTAAAYYHLNAVRIQRAYKLYLAVKNANK 3139

Query: 820  NVNSIVKIQAFFRARKAQDDY-------RILVHAPHPPLSVVRRFAHLLNQSQQDFLAEA 872
             VNS++ IQ +FRAR  +  +       + + H     LS   R A ++ ++ + FL   
Sbjct: 3140 QVNSVICIQRWFRARLQEKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVRHFLLRK 3199

Query: 873  ELLKLQEEVVR-----KIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNK 927
            +  K    +++     +  S ++      I  I++ L V NR   +E      KL KR  
Sbjct: 3200 KQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREE-----NKLYKRTA 3254

Query: 928  EQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPI 968
              L  ++     K L ++       LEA +HL  + +  P+
Sbjct: 3255 LALHYLLT---YKHLSAI-------LEALKHLEVVTRLSPL 3285



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 38/143 (26%), Positives = 68/143 (47%), Gaps = 29/143 (20%)

Query: 710  IQSAVTK-VTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFA-EHSHFLRTWLP----- 762
            IQ A  + VT   + Q+     + F +Q+    R F+ +++ A    H+ RTW       
Sbjct: 2821 IQKAFCRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFL 2880

Query: 763  ----AVIKIQAHWRGY----RQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRL 814
                A + +Q H+R +     QR++YL+          ++I IQA ++ +  +R+     
Sbjct: 2881 LYRKAAVVLQNHYRAFLSAKHQRQVYLQIRS-------SVIIIQARSKGFIQKRK----- 2928

Query: 815  HYFQKNVNSIVKIQAFFRARKAQ 837
              FQ+  NS +KIQA +R  +A+
Sbjct: 2929 --FQEIKNSTIKIQAMWRRYRAK 2949



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 51/246 (20%), Positives = 106/246 (43%), Gaps = 48/246 (19%)

Query: 708  EEIQSAVTKVTAAYDRQQLWKANVGF---VIQLQARLRGFLVRQKFAEHSHFLRTWLPAV 764
            ++ +SAV  + +AY   Q  K  +     VI++Q+  R ++ +++F    +       A 
Sbjct: 1630 QKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKN-------AT 1682

Query: 765  IKIQA------------HWRG--------YRQRKIYLEWLQYFKANLDAIIKIQAWARMW 804
            IK+Q+            H R         YR +KI  +  + +    ++ IK+QA+ R +
Sbjct: 1683 IKLQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGY 1742

Query: 805  AARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLN-- 862
              R+Q        +    +++ +Q++FR RKA+  Y  +  A    + V++ + H     
Sbjct: 1743 LVRKQ-------MRLQRKAVISLQSYFRMRKARQYYLKMYKA----IIVIQNYYHAYKAQ 1791

Query: 863  -QSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVK---NRITLQEVVSH 918
               +++FL   +     +   R  +  Q ++Q  +I  +KI    +    R+  Q V+  
Sbjct: 1792 VNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQ-SIAALKIQSAFRGYNKRVKYQSVLQS 1850

Query: 919  CKKLTK 924
              K+ +
Sbjct: 1851 IIKIQR 1856



 Score = 38.1 bits (87), Expect = 0.070
 Identities = 45/165 (27%), Positives = 75/165 (45%), Gaps = 25/165 (15%)

Query: 737  LQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIK 796
            LQA  RG  VR+        LR    A   IQ+++R YRQ+        YF   L  I K
Sbjct: 2173 LQASFRGVRVRRT-------LRKMQTAATLIQSNYRRYRQQT-------YFN-KLKKITK 2217

Query: 797  IQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRR 856
                 R WA + + ++   Y  K  +S++ IQA FR +KA+   +++  A      + RR
Sbjct: 2218 T-VQQRYWAMKERNIQFQRY-NKLRHSVIYIQAIFRGKKARRHLKMMHIA---ATLIQRR 2272

Query: 857  FAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIK 901
            F  L+ + +   L +  +L     + RK R++   +  L  + ++
Sbjct: 2273 FRTLMMRRRFLSLKKTAIL-----IQRKYRAHLCTKHHLQFLQVQ 2312



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 43/178 (24%), Positives = 84/178 (47%), Gaps = 40/178 (22%)

Query: 764  VIKIQAHWRGYRQRKIY--------------------LEWLQYFKANLDAIIKIQAWARM 803
            +IK QAH R ++QR+ Y                    ++ L  ++    A+I +Q+  R 
Sbjct: 1586 IIKFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRG 1645

Query: 804  WAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQ 863
              AR+ Y+  L        S++KIQ+++RA  ++ ++  L +A     S V+     + Q
Sbjct: 1646 MQARKMYIHIL-------TSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVK-----MKQ 1693

Query: 864  SQQDFL-AEAELLKLQEEVVRKIRSNQQLEQDLNIMD--IKI-----GLLVKNRITLQ 913
            +++ +L   A  L +Q+    K  + Q+ E+ + + +  IK+     G LV+ ++ LQ
Sbjct: 1694 TRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQ 1751



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 67/287 (23%), Positives = 125/287 (43%), Gaps = 45/287 (15%)

Query: 737  LQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIK 796
            +Q R R  ++R++F              I IQ  +R +   K +L++LQ      +A+IK
Sbjct: 2269 IQRRFRTLMMRRRFLSLKK-------TAILIQRKYRAHLCTKHHLQFLQV----QNAVIK 2317

Query: 797  IQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRR 856
            IQ+  R W  R++ +R +H       +   IQ+ FR  +    Y+ L  A     SVV +
Sbjct: 2318 IQSSYRRWMIRKR-MREMH------RAATFIQSTFRMHRLHMRYQALKQA-----SVVIQ 2365

Query: 857  FAHLLNQS----QQDFLAEAELLKLQEEVVRKIRSNQQLE---QDLNIMDIKI-GLLVKN 908
              +  N++    +Q +L +     + +   R +++ + L+       ++  +   LLV+ 
Sbjct: 2366 QQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRR 2425

Query: 909  R-ITLQEV---VSHCKKLTKRNKEQLSDMMVLDK-----QKGLKSLSKEKRQKLEAYQHL 959
            R I+L++    V    + T   K +L   + L K     Q   + L  +K  KL+  Q  
Sbjct: 2426 RFISLKKATIFVQRKYRATICAKHKLYQFLHLRKAAITIQSSYRRLMVKK--KLQEMQRA 2483

Query: 960  FYLLQ-TQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYL 1005
              L+Q T  +Y   + FQ  ++ +    +   +  Y  A  +RE Y+
Sbjct: 2484 AVLIQATFRMYRTYITFQTWKHASILIQQH--YRTYRAAKLQRENYI 2528



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 37/157 (23%), Positives = 64/157 (40%), Gaps = 40/157 (25%)

Query: 708  EEIQSAVTKVTAAY-----DRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLP 762
            E++Q+    +   Y      RQ+  K     +I LQ+R+R  +    +       + +L 
Sbjct: 1344 EKVQNKAASLIQGYWRRYSTRQRFLKLKYYSII-LQSRIRMIIAVTSY-------KRYLW 1395

Query: 763  AVIKIQAHWRGYRQRK------------------IYLEWLQ-YFKANLDAIIKIQAWARM 803
            A + IQ HWR Y +RK                  ++ +W Q   ++ + A + +Q   R 
Sbjct: 1396 ATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQRAFRE 1455

Query: 804  WAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDY 840
            W  R+Q         K  NS + IQ+++R  K    Y
Sbjct: 1456 WHLRKQ--------AKEENSAIIIQSWYRMHKELRKY 1484



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 35/158 (22%), Positives = 73/158 (46%), Gaps = 28/158 (17%)

Query: 763  AVIKIQAHWRGYRQRKIYL-----------EWLQYFKANLDAIIKIQAWARMWAARRQYL 811
            A I IQ H + ++ RK YL            + +       A+I IQ++ R +  R+  +
Sbjct: 2627 AAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKD-I 2685

Query: 812  RRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHL---LNQSQQDF 868
            + +H       +   IQ+F+R  +A+ DY     A    + V++ +  L   +   +++F
Sbjct: 2686 QNMH------RAATLIQSFYRMHRAKVDYETKKTA----IVVIQNYYRLYVRVKTERKNF 2735

Query: 869  LAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLV 906
            LA  + ++  +   R ++  Q+L+   N+ + K+  +V
Sbjct: 2736 LAVQKSVRTIQAAFRGMKVRQKLK---NVSEEKMAAIV 2770



 Score = 31.6 bits (70), Expect = 6.6
 Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 15/106 (14%)

Query: 710  IQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQA 769
            IQS+  ++      Q++ +A     + +QA  R +     F       +TW  A I IQ 
Sbjct: 2464 IQSSYRRLMVKKKLQEMQRA----AVLIQATFRMYRTYITF-------QTWKHASILIQQ 2512

Query: 770  HWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLH 815
            H+R YR  K+  E   Y +    A++   A+  M A  RQ LR  H
Sbjct: 2513 HYRTYRAAKLQRE--NYIRQWHSAVVIQAAYKGMKA--RQLLREKH 2554


>gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo
            sapiens]
          Length = 1487

 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 87/424 (20%), Positives = 174/424 (41%), Gaps = 49/424 (11%)

Query: 885  IRSNQQLEQDLNIMDIKIG--------LLVKNRITLQEVVSHCKKLTK----RNKEQLSD 932
            + S +QL Q LN   +K          +  + RI L  ++    + +     ++ + L D
Sbjct: 20   VNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILED 79

Query: 933  MMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAKLIF---QMPQNKTTKFMEAV 989
               +D   G K L  ++     AY      L+  P  +A  +    ++ Q  T   +  V
Sbjct: 80   TQFVD---GYKQLGFQET----AYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTV 132

Query: 990  IFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNG--R 1047
              SLY     + +   LLQ+ +  ++ E+K   + P+ ++        ++ + +  G   
Sbjct: 133  FTSLYGNCIMQEDESYLLQVLRYLIEFELKES-DNPRRLLRRGTCAFSILFKLFSEGLFS 191

Query: 1048 GQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWI-NQTEAQTGQRSHLPYDVTPEQAL 1106
             +  L   L + I  +L +    + TDP  L + +  +Q E   G++    +        
Sbjct: 192  AKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRF-------- 243

Query: 1107 SHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATD-S 1165
               +VQ  ++     L+A+ +KF+  +  +    P+ +R++   +  TL+    D  +  
Sbjct: 244  -RQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLS--CVDRLEVG 300

Query: 1166 EVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAF 1225
            EV  +  +LL   F+ PAVV P+ + I++ A    +A   R  L  V +LLQ  A   + 
Sbjct: 301  EVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVA---RFNLMQVGRLLQQLAMTGSE 357

Query: 1226 SGQSQHLRVLNDYLEETHLKFRKFI--HRACQVPEPEERFAVDEYSDMVAVAKPMVYITV 1283
             G  +    L  + +     F   +   RA + P       +   + +  +++ +VYIT 
Sbjct: 358  EGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETP------PLSSVNLLEGLSRTVVYITY 411

Query: 1284 GELV 1287
             +L+
Sbjct: 412  SQLI 415


>gi|153945715 myosin VC [Homo sapiens]
          Length = 1742

 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 57/247 (23%), Positives = 106/247 (42%), Gaps = 34/247 (13%)

Query: 711  QSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAH 770
            Q  V K   A   ++ W A     I +Q   RG+LVR  +      +R    A I +QA+
Sbjct: 793  QQTVRKAITAVALKEAWAA-----IIIQKHCRGYLVRSLY----QLIRM---ATITMQAY 840

Query: 771  WRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAF 830
             RG+  R+ Y + L+  KA     + +Q +AR W ARR++ + +  F  N+    ++Q  
Sbjct: 841  SRGFLARRRYRKMLEEHKA-----VILQKYARAWLARRRF-QSIRRFVLNIQLTYRVQ-- 892

Query: 831  FRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQ 890
             R +K  +D     H       +V +   L      D     ++ KL+ E+ +     + 
Sbjct: 893  -RLQKKLEDQNKENH------GLVEKLTSLAALRAGDV---EKIQKLEAELEKAATHRRN 942

Query: 891  LEQD----LNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLS 946
             E+      + ++ K+  L K+   L+      +   +   E+L + M    ++    + 
Sbjct: 943  YEEKGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQ 1002

Query: 947  KEKRQKL 953
            KE+RQ++
Sbjct: 1003 KEERQRM 1009


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 40/146 (27%), Positives = 63/146 (43%), Gaps = 19/146 (13%)

Query: 1048 GQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALS 1107
            G   L E+L  VI  V E+K   +  DP  +            G+   + +    + ALS
Sbjct: 359  GMPYLHEVLKPVISRVFEEKKY-MELDPCKM----------DLGRTRRISF----KGALS 403

Query: 1108 HPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEV 1167
              +++   + +L  L       + AI  SV + P  MR   K L   + E+FP A   +V
Sbjct: 404  EEQMR---ETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDV 460

Query: 1168 -YKVVGNLLYYRFLNPAVVAPDAFDI 1192
             Y  +   L+ RF  PA++ P  FD+
Sbjct: 461  KYLAISGFLFLRFFAPAILTPKLFDL 486


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 46/221 (20%), Positives = 90/221 (40%), Gaps = 35/221 (15%)

Query: 1099 DVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEK 1158
            +++P +   + +V   L   L  L  + +K  +A     + +P  +RY+   L+ ++  K
Sbjct: 829  ELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS----EILPPTLRYIYGCLQKSVQHK 884

Query: 1159 FPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQH 1218
            +P  T     +VV   ++ R + PA++ P  F+I++ +     A      L  VA+ +Q+
Sbjct: 885  WPTNTTMRT-RVVSGFVFLRLICPAILNPRMFNIISDSPSPIAA----RTLILVAKSVQN 939

Query: 1219 AAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPE---PEERFAVDEYSDMVAVA 1275
             A    F  +  ++  +N +++    +   F+     VPE     E    D   D+ A+ 
Sbjct: 940  LANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAAL- 998

Query: 1276 KPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLG 1316
                                H+ C+A  H D L  L  + G
Sbjct: 999  --------------------HEICVA--HSDELRTLSNERG 1017


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 46/221 (20%), Positives = 90/221 (40%), Gaps = 35/221 (15%)

Query: 1099 DVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEK 1158
            +++P +   + +V   L   L  L  + +K  +A     + +P  +RY+   L+ ++  K
Sbjct: 652  ELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS----EILPPTLRYIYGCLQKSVQHK 707

Query: 1159 FPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQH 1218
            +P  T     +VV   ++ R + PA++ P  F+I++ +     A      L  VA+ +Q+
Sbjct: 708  WPTNTTMRT-RVVSGFVFLRLICPAILNPRMFNIISDSPSPIAA----RTLILVAKSVQN 762

Query: 1219 AAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPE---PEERFAVDEYSDMVAVA 1275
             A    F  +  ++  +N +++    +   F+     VPE     E    D   D+ A+ 
Sbjct: 763  LANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAAL- 821

Query: 1276 KPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLG 1316
                                H+ C+A  H D L  L  + G
Sbjct: 822  --------------------HEICVA--HSDELRTLSNERG 840


>gi|222831628 IQ motif containing F5 [Homo sapiens]
          Length = 148

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 31/102 (30%), Positives = 51/102 (50%), Gaps = 23/102 (22%)

Query: 737 LQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGY------RQRKIYLEWLQYFKAN 790
           +QA  RG LVR+     +  LR W+     IQ  WR        ++R++ LE   ++   
Sbjct: 18  IQAWWRGMLVRRTLLHAA--LRAWI-----IQCWWRQVLEKLLAKRRRMVLE---FYVQQ 67

Query: 791 LDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFR 832
             A +++Q+W RMW  R++Y R L       N++  IQ ++R
Sbjct: 68  EWAAVRLQSWVRMWCVRQRYCRLL-------NAVRIIQVYWR 102


>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
          Length = 834

 Score = 41.2 bits (95), Expect = 0.008
 Identities = 26/100 (26%), Positives = 47/100 (47%), Gaps = 5/100 (5%)

Query: 1093 RSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLK 1152
            +SH P ++ P +      ++  ++    NL    D+   AIT S    P  M  +   L+
Sbjct: 405  QSHKPCEIDPVKLKDGENLENNME----NLRQYVDRVFHAITESGVSCPTVMCDIFFSLR 460

Query: 1153 ATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDI 1192
               A++F D  D   Y  V + ++ RF  PA+++P+ F +
Sbjct: 461  EAAAKRFQDDPDVR-YTAVSSFIFLRFFAPAILSPNLFQL 499


>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
            sapiens]
          Length = 1065

 Score = 39.7 bits (91), Expect = 0.024
 Identities = 44/198 (22%), Positives = 80/198 (40%), Gaps = 31/198 (15%)

Query: 1169 KVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQ 1228
            +++   L+ RFL PA+++P  F+++        A      L  +A++ Q+ A    F  +
Sbjct: 391  RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTA----RTLTLIAKVTQNLANFAKFGSK 446

Query: 1229 SQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVG-ELV 1287
             +++  +N +LE      ++F+    ++  PE       +           YI +G EL 
Sbjct: 447  EEYMSFMNQFLEHEWTNMQRFL---LEISNPETLSNTAGFEG---------YIDLGRELS 494

Query: 1288 NTHRLLLEHQDCIAP---DHQDPLHELLEDL---------GELPTIPDLIGESIAADGHT 1335
            + H LL E    +         PL  +L D+         G+LP   DL   S    G +
Sbjct: 495  SLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDL--ASTPGSGSS 552

Query: 1336 DLSKLEVSLTLTNKFEGL 1353
             +S     + + N   GL
Sbjct: 553  SISAGLQKMVIENDLSGL 570


>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
            sapiens]
          Length = 1132

 Score = 39.7 bits (91), Expect = 0.024
 Identities = 44/198 (22%), Positives = 80/198 (40%), Gaps = 31/198 (15%)

Query: 1169 KVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQ 1228
            +++   L+ RFL PA+++P  F+++        A      L  +A++ Q+ A    F  +
Sbjct: 487  RLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTA----RTLTLIAKVTQNLANFAKFGSK 542

Query: 1229 SQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVG-ELV 1287
             +++  +N +LE      ++F+    ++  PE       +           YI +G EL 
Sbjct: 543  EEYMSFMNQFLEHEWTNMQRFL---LEISNPETLSNTAGFEG---------YIDLGRELS 590

Query: 1288 NTHRLLLEHQDCIAP---DHQDPLHELLEDL---------GELPTIPDLIGESIAADGHT 1335
            + H LL E    +         PL  +L D+         G+LP   DL   S    G +
Sbjct: 591  SLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDL--ASTPGSGSS 648

Query: 1336 DLSKLEVSLTLTNKFEGL 1353
             +S     + + N   GL
Sbjct: 649  SISAGLQKMVIENDLSGL 666


>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
          Length = 1139

 Score = 39.3 bits (90), Expect = 0.032
 Identities = 42/200 (21%), Positives = 87/200 (43%), Gaps = 12/200 (6%)

Query: 1169 KVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQ 1228
            +++   L+ RFL PA+++P  F+++        +      L  +A+++Q+ A    F  +
Sbjct: 471  RLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTS----RTLTLIAKVIQNLANFAKFGNK 526

Query: 1229 SQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDM---VAVAKPMVYITVGE 1285
             +++  +ND+LE      ++F+               D Y D+   ++V   +++  V +
Sbjct: 527  EEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQ 586

Query: 1286 LVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIAADGHTDLSKLEVSLT 1345
            L       L  Q  +A     PL  +L D+ +  T P  I + +      + S   VS +
Sbjct: 587  LDKGENSFL--QATVA--KLGPLPRVLADITKSLTNPTPIQQQLRRFTEHN-SSPNVSGS 641

Query: 1346 LTNKFEGLEADADDSNTRSL 1365
            L++  + +  D  DS+   L
Sbjct: 642  LSSGLQKIFEDPTDSDLHKL 661


>gi|215982794 myosin VA isoform 2 [Homo sapiens]
          Length = 1828

 Score = 38.9 bits (89), Expect = 0.041
 Identities = 54/226 (23%), Positives = 110/226 (48%), Gaps = 27/226 (11%)

Query: 735 IQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAI 794
           I++Q  +RG+L+R+K+            A I +Q + RGY Q + Y ++L+  KA   A 
Sbjct: 771 IRIQKTIRGWLLRKKYLR-------MRKAAITMQRYVRGY-QARCYAKFLRRTKA---AT 819

Query: 795 IKIQAWARMWAARRQY-LRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSV 853
           I IQ + RM+  RR+Y +RR         + + +Q++ R   A++ YR ++   H  + +
Sbjct: 820 I-IQKYWRMYVVRRRYKIRRA--------ATIVLQSYLRGFLARNRYRKILR-EHKAVII 869

Query: 854 VRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQ 913
            +R    L  ++  +      +   +   R++ + ++L++ L I    +    K  I ++
Sbjct: 870 QKRVRGWL--ARTHYKRSMHAIIYLQCCFRRMMAKRELKK-LKIEARSVERYKKLHIGME 926

Query: 914 -EVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEK-RQKLEAYQ 957
            +++   +K+ ++NK+    +  L   +G+ +   EK R  LE  Q
Sbjct: 927 NKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQ 972


>gi|215982791 myosin VA isoform 1 [Homo sapiens]
          Length = 1855

 Score = 38.9 bits (89), Expect = 0.041
 Identities = 54/226 (23%), Positives = 110/226 (48%), Gaps = 27/226 (11%)

Query: 735 IQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAI 794
           I++Q  +RG+L+R+K+            A I +Q + RGY Q + Y ++L+  KA   A 
Sbjct: 771 IRIQKTIRGWLLRKKYLR-------MRKAAITMQRYVRGY-QARCYAKFLRRTKA---AT 819

Query: 795 IKIQAWARMWAARRQY-LRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSV 853
           I IQ + RM+  RR+Y +RR         + + +Q++ R   A++ YR ++   H  + +
Sbjct: 820 I-IQKYWRMYVVRRRYKIRRA--------ATIVLQSYLRGFLARNRYRKILR-EHKAVII 869

Query: 854 VRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQ 913
            +R    L  ++  +      +   +   R++ + ++L++ L I    +    K  I ++
Sbjct: 870 QKRVRGWL--ARTHYKRSMHAIIYLQCCFRRMMAKRELKK-LKIEARSVERYKKLHIGME 926

Query: 914 -EVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEK-RQKLEAYQ 957
            +++   +K+ ++NK+    +  L   +G+ +   EK R  LE  Q
Sbjct: 927 NKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQ 972


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 38.5 bits (88), Expect = 0.054
 Identities = 29/91 (31%), Positives = 48/91 (52%), Gaps = 7/91 (7%)

Query: 57  ELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAH- 115
           EL ++LR+GVLL +L +   P  + L+++     LR Q +   F    NI  +LS     
Sbjct: 32  ELAQALRDGVLLCQLLNNLLPHAINLREV----NLRPQMS--QFLCLKNIRTFLSTCCEK 85

Query: 116 IGLPSTFFPETTDIYDKKNMPRVVYCIHALS 146
            GL  +   E  D++D ++  +V+Y + ALS
Sbjct: 86  FGLKRSELFEAFDLFDVQDFGKVIYTLSALS 116


>gi|4507357 transgelin 2 [Homo sapiens]
          Length = 199

 Score = 38.5 bits (88), Expect = 0.054
 Identities = 30/121 (24%), Positives = 59/121 (48%), Gaps = 14/121 (11%)

Query: 21  MDEQRRQNVAYQYLCRLEEAK-RWMEACLKEELPSPVELEESLRN----GVLLAKLGHCF 75
           +  + +Q +  QY   LE+   +W+    ++++  P    E+ +N    G +L +L +  
Sbjct: 10  LSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINAL 69

Query: 76  APS-VVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKKN 134
            P    P+KKI        QA+ + F+  + I+ +L A    G+ +T   +T D+++ KN
Sbjct: 70  YPEGQAPVKKI--------QASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKN 121

Query: 135 M 135
           M
Sbjct: 122 M 122


>gi|122937512 myosin VIIB [Homo sapiens]
          Length = 2116

 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/118 (29%), Positives = 53/118 (44%), Gaps = 20/118 (16%)

Query: 735 IQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAI 794
           + +Q  LRG+  R++F            A + +QA WRGY  R+ +   L  F+  L AI
Sbjct: 768 LSIQKVLRGYRYRKEFLRQRR-------AAVTLQAWWRGYCNRRNFKLILVGFE-RLQAI 819

Query: 795 IKIQAWARMWAARRQ-----------YLRRLHYFQKNVNSIVKIQAFFRARKAQDDYR 841
            + Q  AR + A RQ           YL R    Q    ++V IQA  R   A+ +++
Sbjct: 820 ARSQPLARQYQAMRQRTVQLQALCRGYLVR-QQVQAKRRAVVVIQAHARGMAARRNFQ 876



 Score = 35.4 bits (80), Expect = 0.46
 Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 11/99 (11%)

Query: 735 IQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAI 794
           +QLQA  RG+LVRQ+       ++    AV+ IQAH RG   R+ +    Q  KAN   +
Sbjct: 837 VQLQALCRGYLVRQQ-------VQAKRRAVVVIQAHARGMAARRNF----QQRKANAPLV 885

Query: 795 IKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRA 833
           I  +      A   +  R ++    +   + K+  F  A
Sbjct: 886 IPAEGQKSQGALPAKKRRSIYDTVTDTEMVEKVFGFLPA 924


>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
          Length = 1280

 Score = 38.1 bits (87), Expect = 0.070
 Identities = 44/201 (21%), Positives = 86/201 (42%), Gaps = 21/201 (10%)

Query: 1169 KVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQ 1228
            +++   L+ RFL PA+++P  F+++        +      L  +A+++Q+ A    F  +
Sbjct: 619  RLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTS----RTLTLIAKVIQNLANFAKFGNK 674

Query: 1229 SQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVG-ELV 1287
             +++  +ND+LE      ++F+    ++  P+       +           YI +G EL 
Sbjct: 675  EEYMAFMNDFLEHEWGGMKRFL---LEISNPDTISNTPGFDG---------YIDLGRELS 722

Query: 1288 NTHRLLLE---HQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIAADGHTDLSKLEVSL 1344
              H LL E     D        PL  +L D+ +  T P  I + +      + S   VS 
Sbjct: 723  VLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHN-SSPNVSG 781

Query: 1345 TLTNKFEGLEADADDSNTRSL 1365
            +L++  + +  D  DS+   L
Sbjct: 782  SLSSGLQKIFEDPTDSDLHKL 802


>gi|5454102 transforming, acidic coiled-coil containing protein 3
           [Homo sapiens]
          Length = 838

 Score = 38.1 bits (87), Expect = 0.070
 Identities = 38/150 (25%), Positives = 71/150 (47%), Gaps = 22/150 (14%)

Query: 814 LHYFQKNVNSIVKIQAFFRARKAQDDYRIL------VHAPHPPLS-VVRRFAHLLNQSQQ 866
           L Y QK+++++VK          Q++ R L      +H  +  L  ++ RF  ++ Q+ +
Sbjct: 637 LQYSQKDLDAVVKA--------TQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAME 688

Query: 867 DFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRN 926
           +   + EL K   E+ + ++   QL  DLN M+     L K     +EV+   +K  +  
Sbjct: 689 EVQKQKELSKA--EIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESL 746

Query: 927 KEQLSDMMVLDKQKG-----LKSLSKEKRQ 951
           K+ + D +    Q+G     LK+ ++EK Q
Sbjct: 747 KKCVEDYLARITQEGQRYQALKAHAEEKLQ 776


>gi|224451032 KIAA1683 isoform a [Homo sapiens]
          Length = 1367

 Score = 37.7 bits (86), Expect = 0.092
 Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 7/45 (15%)

Query: 734  VIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRK 778
            VI +QA +RG+L R++       +R W    + IQA WRGYR R+
Sbjct: 1117 VITIQAGVRGYLARRR-------IRLWHRGAMVIQATWRGYRVRR 1154


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 37.7 bits (86), Expect = 0.092
 Identities = 66/308 (21%), Positives = 124/308 (40%), Gaps = 44/308 (14%)

Query: 871  EAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQL 930
            +AE  +LQ++   K +   QL+ ++N +  K   L++    L E     K+  + + E+L
Sbjct: 392  KAEFKQLQQQREEKEQHGLQLQSEINQLHSK---LLETERQLGEAHGRLKEQRQLSSEKL 448

Query: 931  SD--MMVLDKQKGLKSLSKEKRQKLEAYQHLFYLL-QTQPIYLAKLIFQMPQNKTTKFME 987
             D    V D Q  L  L ++ ++K+     L + L +T+  +  +   Q  Q+ T K  E
Sbjct: 449  MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ--QSTTAKLRE 506

Query: 988  A------VIFSLYNYASSRREAYLLLQLFKTAL------QEEIKSKVEQPQDVV------ 1029
            A      V+  + +     +    LLQ  K  +      +E++ +K++  +         
Sbjct: 507  AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566

Query: 1030 -----TGNPTVVRLVVRFYRNGRGQSALQEILGKVIQD------VLEDKVLSVHTDPVHL 1078
                 T    V +L  +           QE L   +Q+        +D+VLS+ T    L
Sbjct: 567  QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626

Query: 1079 ------YKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLA 1132
                   K  ++Q + Q   ++ L       +     ++Q  LD A +N L    + L  
Sbjct: 627  NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA-QNALQDKQQELNK 685

Query: 1133 ITSSVDQI 1140
            IT+ +DQ+
Sbjct: 686  ITTQLDQV 693


>gi|224451036 KIAA1683 isoform c [Homo sapiens]
          Length = 1134

 Score = 37.7 bits (86), Expect = 0.092
 Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 7/45 (15%)

Query: 734 VIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRK 778
           VI +QA +RG+L R++       +R W    + IQA WRGYR R+
Sbjct: 884 VITIQAGVRGYLARRR-------IRLWHRGAMVIQATWRGYRVRR 921


>gi|54606862 KIAA1683 isoform b [Homo sapiens]
          Length = 1180

 Score = 37.7 bits (86), Expect = 0.092
 Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 7/45 (15%)

Query: 734 VIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRK 778
           VI +QA +RG+L R++       +R W    + IQA WRGYR R+
Sbjct: 930 VITIQAGVRGYLARRR-------IRLWHRGAMVIQATWRGYRVRR 967


>gi|28269672 serologically defined colon cancer antigen 8 [Homo
           sapiens]
          Length = 713

 Score = 37.7 bits (86), Expect = 0.092
 Identities = 85/387 (21%), Positives = 147/387 (37%), Gaps = 42/387 (10%)

Query: 130 YDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASE-----LAKYGL 184
           +++ NMP +   +H ++        +  IH L  +VKF  EELS M ++     L   GL
Sbjct: 107 HEETNMPTMHDLVHTIN------DQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGL 160

Query: 185 QLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDT------------LAALQN 232
           Q    S+       E ++ +A+ +     I    + GV E +             AA   
Sbjct: 161 QQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAG 220

Query: 233 PSALLENLR---EPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNIN 289
               LE L+   E    + +  L   + + A   R  +D + Q  +  +L  A     + 
Sbjct: 221 EQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVG 280

Query: 290 HVNV-----HGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQ 344
            + +        L      +  Q+ E L+K   D   AL  VR   AD    +  S  EQ
Sbjct: 281 GLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREA-SAYEQ 339

Query: 345 KAQELGLVELLEKEEVQAGVAAANTKGDQE-QAMLHAVQRINKAIRRGVAADTVKELMCP 403
             Q L + E    E+ +A +     + + E QA     +  ++  +R +  D +K+ +  
Sbjct: 340 VKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITK 399

Query: 404 EAQLPPVYPVASSMYQLELAVLQ-QQQGELGQEELFVAVEMLSAV--VLINRALEARDAS 460
           E +      + S M  L   + Q + Q E   +E   A+  L  +   L +R ++     
Sbjct: 400 EREY-----MGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVC 454

Query: 461 GFWSSLVNPATGLAEVEGENAQRYFDA 487
           G     +N  T + + E E   R F A
Sbjct: 455 GEMRYQLN-KTNMEKDEAEKEHREFRA 480


>gi|156119615 myosin IXA [Homo sapiens]
          Length = 2548

 Score = 37.4 bits (85), Expect = 0.12
 Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 10/100 (10%)

Query: 711  QSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAH 770
            + A    +AA   Q  W+A++     L+ R    +++QK+ +   + R    A I IQA 
Sbjct: 1069 KDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRD---YYRRRHMAAICIQAR 1125

Query: 771  WRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQY 810
            W+ YR+ K Y E           II +Q+  R + AR+++
Sbjct: 1126 WKAYRESKRYQE-------QRKKIILLQSTCRGFRARQRF 1158


>gi|189083802 myosin VIIA isoform 2 [Homo sapiens]
          Length = 2175

 Score = 37.4 bits (85), Expect = 0.12
 Identities = 46/184 (25%), Positives = 77/184 (41%), Gaps = 50/184 (27%)

Query: 728 KANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIY----LEW 783
           KA    VI LQ  +RGF  R  F +  +       A   IQ HWRG+  RK Y    L +
Sbjct: 742 KAITDRVILLQKVIRGFKDRSNFLKLKN-------AATLIQRHWRGHNCRKNYGLMRLGF 794

Query: 784 L------------QYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFF 831
           L            Q ++     II+ QA  R +  R+ +  RL        +++ +QA+ 
Sbjct: 795 LRLQALHRSRKLHQQYRLARQRIIQFQARCRAYLVRKAFRHRLW-------AVLTVQAYA 847

Query: 832 RARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKL-QEEVVRKIRSNQQ 890
           R                    ++ R  H   +++  +  EAE ++L +EE +RK  S ++
Sbjct: 848 R-------------------GMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAKK 888

Query: 891 LEQD 894
            +++
Sbjct: 889 AKEE 892


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,034,125
Number of Sequences: 37866
Number of extensions: 2449047
Number of successful extensions: 8181
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 104
Number of HSP's that attempted gapping in prelim test: 7785
Number of HSP's gapped (non-prelim): 402
length of query: 1631
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1515
effective length of database: 13,855,062
effective search space: 20990418930
effective search space used: 20990418930
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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