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Search of human proteins with 38569491
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
(1263 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 2567 0.0
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 461 e-129
gi|116256471 SNF1-like kinase [Homo sapiens] 409 e-114
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 382 e-105
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 382 e-105
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 382 e-105
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 382 e-105
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 382 e-105
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 381 e-105
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 381 e-105
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 381 e-105
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 381 e-105
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 379 e-104
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 378 e-104
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 294 4e-79
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 292 2e-78
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 271 3e-72
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 265 2e-70
gi|156105707 SNF related kinase [Homo sapiens] 265 3e-70
gi|156105705 SNF related kinase [Homo sapiens] 265 3e-70
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 261 2e-69
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 255 2e-67
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 251 2e-66
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 241 2e-63
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 240 7e-63
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 199 1e-50
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 199 1e-50
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 187 4e-47
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 183 8e-46
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 179 2e-44
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 2567 bits (6653), Expect = 0.0
Identities = 1263/1263 (100%), Positives = 1263/1263 (100%)
Query: 1 MPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMK 60
MPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMK
Sbjct: 1 MPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMK 60
Query: 61 MLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYF 120
MLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYF
Sbjct: 61 MLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYF 120
Query: 121 CHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKE 180
CHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKE
Sbjct: 121 CHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKE 180
Query: 181 YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHML 240
YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHML
Sbjct: 181 YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHML 240
Query: 241 VLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL 300
VLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL
Sbjct: 241 VLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL 300
Query: 301 DKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAG 360
DKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAG
Sbjct: 301 DKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAG 360
Query: 361 TAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTE 420
TAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTE
Sbjct: 361 TAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTE 420
Query: 421 VMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQ 480
VMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQ
Sbjct: 421 VMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQ 480
Query: 481 LLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQ 540
LLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQ
Sbjct: 481 LLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQ 540
Query: 541 EAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQL 600
EAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQL
Sbjct: 541 EAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQL 600
Query: 601 QKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALL 660
QKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALL
Sbjct: 601 QKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALL 660
Query: 661 THQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIF 720
THQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIF
Sbjct: 661 THQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIF 720
Query: 721 QQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPS 780
QQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPS
Sbjct: 721 QQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPS 780
Query: 781 AGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQ 840
AGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQ
Sbjct: 781 AGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQ 840
Query: 841 SRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPD 900
SRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPD
Sbjct: 841 SRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPD 900
Query: 901 YTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQEL 960
YTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQEL
Sbjct: 901 YTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQEL 960
Query: 961 FRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPT 1020
FRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPT
Sbjct: 961 FRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPT 1020
Query: 1021 PPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPES 1080
PPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPES
Sbjct: 1021 PPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPES 1080
Query: 1081 LLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYP 1140
LLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYP
Sbjct: 1081 LLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYP 1140
Query: 1141 ARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLM 1200
ARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLM
Sbjct: 1141 ARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLM 1200
Query: 1201 GSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQ 1260
GSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQ
Sbjct: 1201 GSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQ 1260
Query: 1261 AGV 1263
AGV
Sbjct: 1261 AGV 1263
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 461 bits (1185), Expect = e-129
Identities = 323/871 (37%), Positives = 441/871 (50%), Gaps = 158/871 (18%)
Query: 2 PARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKM 61
P R+G+Y+I+ T+GKGNFAVVK H +TK +VAIKIIDK+QLD NL+KI+REVQIMKM
Sbjct: 14 PVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKM 73
Query: 62 LCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFC 121
L HPHII+LYQVMET+ M+YLVTEYA GEIFD+L HGR+ E EARRKF QI++AV +C
Sbjct: 74 LDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYC 133
Query: 122 HCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEY 181
H R IVHRDLKAENLLLD N+NIKIADFGF N F G+LL TWCGSPPYAAPE+FEG++Y
Sbjct: 134 HGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQY 193
Query: 182 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLV 241
+GP++DIWS+GVVLYVLVCGALPFDG TL LR RVL G+FRIP+FMS +CEHLIR MLV
Sbjct: 194 EGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLV 253
Query: 242 LDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD 301
LDP+KRL++ QI +HKWM + + R + Q+ + E + NE VL M +G+D
Sbjct: 254 LDPSKRLTIAQIKEHKWMLI---EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGID 310
Query: 302 KEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKT---------------------------- 333
+++T++SL++ +Y+H++AIY LL +R K H++
Sbjct: 311 QQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT 370
Query: 334 --------------LRLGALPSMPRALAFQAPVN-IQAEQAGTAMN-ISVPQVQ--LINP 375
LR LP AF P + QAE A + P+V L++P
Sbjct: 371 VGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDP 430
Query: 376 ENQIVEPDGTLNLDSD--------------EGEEPSPEALVRYLS----MRRHTVGVADP 417
++ G +L S+ E EE A + S RRHT+
Sbjct: 431 VPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTN 490
Query: 418 RTEVMEDLQKLL-----PGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQS 472
+ VM K+ P V+ + V ++NF+ + ++++ Q + S
Sbjct: 491 QLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTS 550
Query: 473 ---LLQP--PTLQLLNGM-------GPL----GRRASDGGAN------------------ 498
L+P P +Q L+ P+ GRRASD
Sbjct: 551 PFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKG 610
Query: 499 -IQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLP 557
++L+ QLL GP + PA P + + E Q+ ST S +H
Sbjct: 611 ILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPAS--VH-- 666
Query: 558 TERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQ 617
+ SP + + Q + L+K S + + Q C+ K ++++ E
Sbjct: 667 -PQLSPRQ-----SLETQYLQHRLQK---PSLLSKAQNTCQLYCKEPPRSLEQQLQEHRL 717
Query: 618 QQHMLYQQEQHH--------QILQ-------QQI----QDSICPPQPSPPLQAACENQPA 658
QQ L+ Q+Q QI + QQ+ Q++ P Q +PP P
Sbjct: 718 QQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPV 777
Query: 659 L-----------LTHQLQRLRIQP----SSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHG 703
L Q Q +++QP S P P +Q PPP QP
Sbjct: 778 LEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGA 837
Query: 704 AASSSQFQ----GLPSRSAIFQQQPENCSSP 730
A + QF LPS ++ P C P
Sbjct: 838 APAPLQFSYQTCELPSAASPAPDYPTPCQYP 868
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 409 bits (1051), Expect = e-114
Identities = 194/334 (58%), Positives = 259/334 (77%), Gaps = 8/334 (2%)
Query: 2 PARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKM 61
P R+G+Y+I+RT+GKGNFAVVK A H VTK +VAIKIIDKT+LD NL+KI+REVQ+MK+
Sbjct: 21 PLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKL 80
Query: 62 LCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFC 121
L HPHII+LYQVMET+ M+Y+VTE+A GE+FD+L ++G ++E EAR+KF QI++AV +C
Sbjct: 81 LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140
Query: 122 HCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEY 181
H +IVHRDLK ENLLLD N++IK+ADFGF N + G+ L TWCGSPPYAAPE+FEGKEY
Sbjct: 141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEY 200
Query: 182 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLV 241
+GP++DIWSLGVVLYVLVCG+LPFDG L LR RVL G+FRIPFFMS +CE LIR MLV
Sbjct: 201 EGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLV 260
Query: 242 LDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPL---NEDVLLAMEDM 298
+DP +R+++ QI +H+WM+ P C L +E L M+ +
Sbjct: 261 VDPARRITIAQIRQHRWMRAEPCLPG-----PACPAFSAHSYTSNLGDYDEQALGIMQTL 315
Query: 299 GLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHK 332
G+D+++T++SL++ +Y+H++AIY LL +R K ++
Sbjct: 316 GVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYR 349
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 382 bits (980), Expect = e-105
Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VA+KIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ L+L+P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
+KR ++EQI K +WM +G D + K+ R+ + M MG +E+
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 341
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
SL Y+ A Y LL
Sbjct: 342 IQDSLVGQRYNEVMATYLLL 361
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 382 bits (980), Expect = e-105
Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VA+KIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ L+L+P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
+KR ++EQI K +WM +G D + K+ R+ + M MG +E+
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 341
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
SL Y+ A Y LL
Sbjct: 342 IQDSLVGQRYNEVMATYLLL 361
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 382 bits (980), Expect = e-105
Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VA+KIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ L+L+P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
+KR ++EQI K +WM +G D + K+ R+ + M MG +E+
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 341
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
SL Y+ A Y LL
Sbjct: 342 IQDSLVGQRYNEVMATYLLL 361
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 382 bits (980), Expect = e-105
Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VA+KIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ L+L+P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
+KR ++EQI K +WM +G D + K+ R+ + M MG +E+
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 341
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
SL Y+ A Y LL
Sbjct: 342 IQDSLVGQRYNEVMATYLLL 361
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 382 bits (980), Expect = e-105
Identities = 187/320 (58%), Positives = 243/320 (75%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VA+KIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 17 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 76
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 77 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 137 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 196
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ L+L+P
Sbjct: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
+KR ++EQI K +WM +G D + K+ R+ + M MG +E+
Sbjct: 257 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTREE 308
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
SL Y+ A Y LL
Sbjct: 309 IQDSLVGQRYNEVMATYLLL 328
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 381 bits (978), Expect = e-105
Identities = 186/320 (58%), Positives = 245/320 (76%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VAIKIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YL+ EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ LVL+P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
KR ++EQI K +W+ G + + + +++++D M MG +E+
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID--------IMVGMGYSQEE 344
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
+SL YD +A Y LL
Sbjct: 345 IQESLSKMKYDEITATYLLL 364
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 381 bits (978), Expect = e-105
Identities = 186/320 (58%), Positives = 245/320 (76%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VAIKIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YL+ EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ LVL+P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
KR ++EQI K +W+ G + + + +++++D M MG +E+
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID--------IMVGMGYSQEE 344
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
+SL YD +A Y LL
Sbjct: 345 IQESLSKMKYDEITATYLLL 364
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 381 bits (978), Expect = e-105
Identities = 186/320 (58%), Positives = 245/320 (76%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VAIKIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YL+ EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ LVL+P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
KR ++EQI K +W+ G + + + +++++D M MG +E+
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID--------IMVGMGYSQEE 344
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
+SL YD +A Y LL
Sbjct: 345 IQESLSKMKYDEITATYLLL 364
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 381 bits (978), Expect = e-105
Identities = 186/320 (58%), Positives = 245/320 (76%), Gaps = 8/320 (2%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VAIKIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YL+ EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ LVL+P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
KR ++EQI K +W+ G + + + +++++D M MG +E+
Sbjct: 293 IKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID--------IMVGMGYSQEE 344
Query: 305 TLQSLRSDAYDHYSAIYSLL 324
+SL YD +A Y LL
Sbjct: 345 IQESLSKMKYDEITATYLLL 364
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 379 bits (973), Expect = e-104
Identities = 190/322 (59%), Positives = 246/322 (76%), Gaps = 12/322 (3%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
IG Y + +TIGKGNFA VK A H++T +VA+KIIDKTQL+ +L+K+FREV+IMK+L H
Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNH 116
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YLV EYASGGE+FD+LVAHGRM EKEAR KF+QIV+AV +CH +
Sbjct: 117 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 176
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
IVHRDLKAENLLLD ++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 177 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 236
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VD+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST+CE+L++ +LVL+P
Sbjct: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV--LLAMEDMGLDK 302
KR S+EQI K +WM +G E ++LK + DP D + M MG +
Sbjct: 297 IKRGSLEQIMKDRWMNVGH----------EEEELKPYTEPDPDFNDTKRIDIMVTMGFAR 346
Query: 303 EQTLQSLRSDAYDHYSAIYSLL 324
++ +L + YD A Y LL
Sbjct: 347 DEINDALINQKYDEVMATYILL 368
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 378 bits (970), Expect = e-104
Identities = 191/322 (59%), Positives = 245/322 (76%), Gaps = 12/322 (3%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
+G Y + RTIGKGNFA VK A H++T +VAIKIIDKTQL+ +L+K+FREV+IMK L H
Sbjct: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 115
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
P+I++L++V+ETE+ +YLV EYAS GE+FD+LV+HGRM EKEAR KF+QIV+AV++CH +
Sbjct: 116 PNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
NIVHRDLKAENLLLDA NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 176 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+VDIWSLGV+LY LV G+LPFDG L+ LR RVL GK+R+PF+MST+CE ++R LVL+P
Sbjct: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLK--EERQVDPLNEDVLLAMEDMGLDK 302
KR ++EQI K KW+ +G E ++LK E + D + + M MG +
Sbjct: 296 AKRCTLEQIMKDKWINIG----------YEGEELKPYTEPEEDFGDTKRIEVMVGMGYTR 345
Query: 303 EQTLQSLRSDAYDHYSAIYSLL 324
E+ +SL S Y+ +A Y LL
Sbjct: 346 EEIKESLTSQKYNEVTATYLLL 367
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 294 bits (752), Expect = 4e-79
Identities = 147/338 (43%), Positives = 220/338 (65%), Gaps = 2/338 (0%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
+G Y +++T+GKG +VK H VT KVAIKI+++ +L E L K+ RE+ I+K++ H
Sbjct: 16 VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 75
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
PH+++L+ V E ++ +YLV E+ SGGE+FD+LV GR+ KEAR+ F+QI++A+ FCH
Sbjct: 76 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 135
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
+I HRDLK ENLLLD NI+IADFG ++L LL+T CGSP YA PE+ G++YDG
Sbjct: 136 SICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 195
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
K D+WS GV+L+ L+ GALPFD L+ L +V G F +P F+ +C+ L+R M+ +D
Sbjct: 196 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDA 255
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL--DK 302
+RL++E I KH W G +P ++ I Q++ ++ ++ DVL +M +G D+
Sbjct: 256 ARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDR 315
Query: 303 EQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALP 340
+ LQ L S+ + IY LL DR +R+ + LP
Sbjct: 316 NKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLP 353
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 292 bits (747), Expect = 2e-78
Identities = 149/340 (43%), Positives = 220/340 (64%), Gaps = 4/340 (1%)
Query: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
+G Y +++T+GKG +VK H +T KVAIKI+++ +L E L K+ RE+ I+K++ H
Sbjct: 31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 90
Query: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
PH+++L+ V E ++ +YLV E+ SGGE+FD+LV GR+ KEAR+ F+QIV+A+ FCH
Sbjct: 91 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSY 150
Query: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
+I HRDLK ENLLLD NI+IADFG ++L LL+T CGSP YA PE+ +G++YDG
Sbjct: 151 SICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGR 210
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+ D+WS GV+L+ L+ GALPFD L+ L +V G F +P F+ +C+ L+R M+ ++P
Sbjct: 211 RADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEP 270
Query: 245 NKRLSMEQICKHKWMKLG--DADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL-- 300
KRLS+EQI KH W G + DP + ++ L+ DVL +M +G
Sbjct: 271 EKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFR 330
Query: 301 DKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALP 340
D+E+ + LRS+ + IY LL DR +R+ + LP
Sbjct: 331 DRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLP 370
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 271 bits (693), Expect = 3e-72
Identities = 141/334 (42%), Positives = 207/334 (61%), Gaps = 21/334 (6%)
Query: 4 RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDE-ENLKKIFREVQIMKML 62
+IG+Y + T+G G F VK H +T KVA+KI+++ ++ + + KI RE+Q +K+
Sbjct: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
Query: 63 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH 122
HPHII+LYQV+ T ++V EY SGGE+FD++ HGR+ E EARR F+QI++AV +CH
Sbjct: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
Query: 123 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD 182
+VHRDLK EN+LLDA++N KIADFG SN+ + G+ L+T CGSP YAAPE+ G+ Y
Sbjct: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191
Query: 183 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL 242
GP+VDIWS GV+LY L+CG LPFD + L ++ G F IP +++ L+ HML +
Sbjct: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQV 251
Query: 243 DPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAME 296
DP KR +++ I +H+W K L DP++D + + + +KE E
Sbjct: 252 DPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKE-------------VCE 298
Query: 297 DMGLDKEQTLQSLRS-DAYDHYSAIYSLLCDRHK 329
+ + + SL S D D + Y L+ D +
Sbjct: 299 KFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRR 332
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 265 bits (677), Expect = 2e-70
Identities = 132/298 (44%), Positives = 199/298 (66%), Gaps = 7/298 (2%)
Query: 4 RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDE-ENLKKIFREVQIMKML 62
+IG+Y + T+G G F VK H +T KVA+KI+++ ++ + + KI RE+Q +K+
Sbjct: 23 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 82
Query: 63 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH 122
HPHII+LYQV+ T I++V EY SGGE+FD++ +GR+ EKE+RR F+QI++ V +CH
Sbjct: 83 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 142
Query: 123 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD 182
+VHRDLK EN+LLDA++N KIADFG SN+ + G+ L+T CGSP YAAPE+ G+ Y
Sbjct: 143 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 202
Query: 183 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL 242
GP+VDIWS GV+LY L+CG LPFD + L ++ G F P +++ L++HML +
Sbjct: 203 GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQV 262
Query: 243 DPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLA 294
DP KR +++ I +H+W K L DP++ + + + LKE + +E+ +L+
Sbjct: 263 DPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLS 320
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 265 bits (676), Expect = 3e-70
Identities = 136/331 (41%), Positives = 209/331 (63%), Gaps = 8/331 (2%)
Query: 6 GYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHP 65
G Y++D+T+G+G+FAVVK A H+ T KVA+K+IDKT+LD +F+EV+ MK++ HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 66 HIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCR 124
+I+RLY+V++T+ +YL+ E GG++FD+++ H + E A++ F QIV A+ +CH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 125 NIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDG 183
++VHRDLK EN++ +K+ DFGFSN F PG+ L T CGS Y+APE+ G EYD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 184 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLD 243
P VDIWSLGV+L++LVCG PF + ++ K+ +P +S EC+ LI ML D
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 244 PNKRLSMEQICKHKWMKLGDADP--NFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD 301
P +R S+E+I H W++ D P ++ + + L EE + VL + D
Sbjct: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI----AD 309
Query: 302 KEQTLQSLRSDAYDHYSAIYSLLCDRHKRHK 332
++ +++L ++ Y+H +A Y LL +R R K
Sbjct: 310 RDAIVEALETNRYNHITATYFLLAERILREK 340
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 265 bits (676), Expect = 3e-70
Identities = 136/331 (41%), Positives = 209/331 (63%), Gaps = 8/331 (2%)
Query: 6 GYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHP 65
G Y++D+T+G+G+FAVVK A H+ T KVA+K+IDKT+LD +F+EV+ MK++ HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 66 HIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCR 124
+I+RLY+V++T+ +YL+ E GG++FD+++ H + E A++ F QIV A+ +CH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 125 NIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDG 183
++VHRDLK EN++ +K+ DFGFSN F PG+ L T CGS Y+APE+ G EYD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 184 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLD 243
P VDIWSLGV+L++LVCG PF + ++ K+ +P +S EC+ LI ML D
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 244 PNKRLSMEQICKHKWMKLGDADP--NFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD 301
P +R S+E+I H W++ D P ++ + + L EE + VL + D
Sbjct: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI----AD 309
Query: 302 KEQTLQSLRSDAYDHYSAIYSLLCDRHKRHK 332
++ +++L ++ Y+H +A Y LL +R R K
Sbjct: 310 RDAIVEALETNRYNHITATYFLLAERILREK 340
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 261 bits (668), Expect = 2e-69
Identities = 135/340 (39%), Positives = 202/340 (59%)
Query: 4 RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLC 63
RIG+Y I IG GNF+ VK H +TK KVAIKI+DKT+LD++ + + RE+ M+ L
Sbjct: 70 RIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLH 129
Query: 64 HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC 123
HP+IIRLY+V+ET ++LV EYA GGE+F + G+++E E++ F QIV+AV H
Sbjct: 130 HPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHE 189
Query: 124 RNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDG 183
I+HRDLKAEN+ +N +K+ DFGFS + G++L T+CGSPPYAAPELF + Y G
Sbjct: 190 NQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIG 249
Query: 184 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLD 243
VDIW+LGV+LY +V G +PF T+ L+ +L G + +P +S C LIR +L
Sbjct: 250 IYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQI 309
Query: 244 PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKE 303
P +R ++ I +WM+ + + + L E + +V +E +G+ +E
Sbjct: 310 PTERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITEE 369
Query: 304 QTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMP 343
+ DA + +Y ++ R +R K L + +P
Sbjct: 370 HIRNNQGRDARSSITGVYRIILHRVQRKKALESVPVMMLP 409
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 255 bits (651), Expect = 2e-67
Identities = 132/313 (42%), Positives = 199/313 (63%), Gaps = 22/313 (7%)
Query: 4 RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDE-ENLKKIFREVQIMKML 62
+IG+Y + T+G G F VK H +T KVA+KI+++ ++ + + KI RE+Q +K+
Sbjct: 23 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 82
Query: 63 CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMA---------------EKEA 107
HPHII+LYQV+ T I++V EY SGGE+FD++ +GR + EKE+
Sbjct: 83 RHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKES 142
Query: 108 RRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS 167
RR F+QI++ V +CH +VHRDLK EN+LLDA++N KIADFG SN+ + G+ L+T CGS
Sbjct: 143 RRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS 202
Query: 168 PPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFF 227
P YAAPE+ G+ Y GP+VDIWS GV+LY L+CG LPFD + L ++ G F P +
Sbjct: 203 PNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQY 262
Query: 228 MSTECEHLIRHMLVLDPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEE 281
++ L++HML +DP KR +++ I +H+W K L DP++ + + + LKE
Sbjct: 263 LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEV 322
Query: 282 RQVDPLNEDVLLA 294
+ +E+ +L+
Sbjct: 323 CEKFECSEEEVLS 335
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 251 bits (642), Expect = 2e-66
Identities = 125/274 (45%), Positives = 184/274 (67%), Gaps = 7/274 (2%)
Query: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPH 66
YE+ T+GKG + VKRAT + VAIK I K ++ DE+++ I RE++IM L HPH
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
II +Y+V E + I ++ EYAS GE++D++ R++E+E R F+QIV+AV++CH +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 186
VHRDLK EN+LLD N NIKIADFG SNL+ + L+T+CGSP YA+PE+ G+ Y GP+V
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 187 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 246
D W+LGV+LY LV G +PFDG +NL ++ SG++R P ++ LIR ML+++P++
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
Query: 247 RLSMEQICKHKWMKLGDADPNFDRLIAECQQLKE 280
R ++E I H W+ G + + +C L +
Sbjct: 294 RATIEDIANHWWVNWG-----YKSSVCDCDALHD 322
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 241 bits (616), Expect = 2e-63
Identities = 124/258 (48%), Positives = 177/258 (68%), Gaps = 3/258 (1%)
Query: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPH 66
YE T+GKG + VK+A + VAIK I K ++ DE++L I RE++IM L HPH
Sbjct: 53 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
II +++V E I +V EYAS G+++D++ +++E+EAR F+QIV+AV++CH +
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171
Query: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 186
VHRDLK EN+LLDAN NIKIADFG SNL+ G+ L+T+CGSP YA+PE+ GK Y GP+V
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 187 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 246
D WSLGV+LY+LV G +PFDG + L ++ +G +R P S C LIR +L+++P +
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290
Query: 247 RLSMEQICKHKWMKLGDA 264
R ++E + H W+ G A
Sbjct: 291 RATLEDVASHWWVNWGYA 308
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 240 bits (612), Expect = 7e-63
Identities = 133/333 (39%), Positives = 197/333 (59%), Gaps = 13/333 (3%)
Query: 7 YYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPH 66
YYE+ TIG G FA VK A H++T VAIKI+DK L + L +I E++ +K L H H
Sbjct: 10 YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQH 68
Query: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
I +LY V+ET I++V EY GGE+FD++++ R++E+E R F+QIV+AV + H +
Sbjct: 69 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
Query: 127 VHRDLKAENLLLDANLNIKIADFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
HRDLK ENLL D +K+ DFG L+T CGS YAAPEL +GK Y G
Sbjct: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
Query: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
+ D+WS+G++LYVL+CG LPFD + L +++ GK+ +P ++S L++ ML +DP
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
Query: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 304
KR+SM+ + H W+ D N+ + + + L++D + + + Q
Sbjct: 249 KKRISMKNLLNHPWIM---QDYNYP------VEWQSKNPFIHLDDDCVTELSVHHRNNRQ 299
Query: 305 TLQSLRS-DAYDHYSAIYSLLCDRHKRHKTLRL 336
T++ L S YDH +A Y LL + R K +RL
Sbjct: 300 TMEDLISLWQYDHLTATYLLLLAKKARGKPVRL 332
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 199 bits (507), Expect = 1e-50
Identities = 125/341 (36%), Positives = 188/341 (55%), Gaps = 22/341 (6%)
Query: 4 RIGYYEI-DRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENL--KKIFREVQIMK 60
R+G Y I R +G+G+FA V+ H++T KVAIK+IDK + ++ K + RE QI +
Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
Query: 61 MLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYF 120
M+ HP+I +L ++ETE YLV E GG + + R+ E EARR +Q+++AV
Sbjct: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
Query: 121 CHCRNIVHRDLKAENLLLDANLNIKIADFGFSN---LFTPGQLLKTWCGSPPYAAPELFE 177
H +VHRDLK ENLLLD + NIK+ DFG SN + T CGSP YAAPEL
Sbjct: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
Query: 178 GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKF------RIPFFMSTE 231
K+Y GPK+D+WS+GV +Y ++ G LPF T++ R L K +P +ST
Sbjct: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPF---TVEPFSLRALYQKMVDKEMNPLPTQLSTG 292
Query: 232 CEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV 291
+R +L DP KR +++Q ++W+ + N+ + ++ L+ V
Sbjct: 293 AISFLRSLLEPDPVKRPNIQQALANRWL-----NENYTGKVPCNVTYPNRISLEDLSPSV 347
Query: 292 LLAM-EDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRH 331
+L M E +G + ++ S+ H AIY LL + +R+
Sbjct: 348 VLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERY 388
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 199 bits (506), Expect = 1e-50
Identities = 108/264 (40%), Positives = 163/264 (61%), Gaps = 13/264 (4%)
Query: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPH 66
Y + +G+G++A VK A K VAIKIID+ + + L+K RE++I+ ML H
Sbjct: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Query: 67 IIRLYQVMETER-MIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 125
II+ Y++ ET +Y+V E A G++ + + G + E EAR+KF Q+ A+ +CH +
Sbjct: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
Query: 126 IVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ-----LLKTWCGSPPYAAPELFEGKE 180
+VHRDLK +NLLLD + NIK++DF FS L KT+CGSP YAAPE+ +G
Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
Query: 181 YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF----FMSTECEHLI 236
Y DIWSLGV+LY++VCG++P+D S ++ + + + R+ F ++ EC+ LI
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Query: 237 RHMLVLDPNKRLSMEQICKHKWMK 260
HML D N+RL +++I H WM+
Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWMQ 273
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 187 bits (476), Expect = 4e-47
Identities = 100/257 (38%), Positives = 162/257 (63%), Gaps = 6/257 (2%)
Query: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPH 66
Y++ +TIG+G ++ VK A + KVAIK+IDK EE +++ RE+QI++ L H +
Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Query: 67 IIRLYQVMET-ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 125
II++Y+++E+ + I LV E A GG++FD ++ G + E A+ F+Q+V A+ +CH
Sbjct: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
Query: 126 IVHRDLKAENLLLDANLNIKIADFGFSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDG 183
+ HRDLK EN LL N+K+ DFGF+ + +L +T+CGS YAAPE+ +G +D
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
Query: 184 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSG-KFRIPFFMSTECEHLIRHMLVL 242
K D+WS+GVVLYV++C +LPFD + + + + G F +S +C+ L++ +L
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
Query: 243 DPNKRLSMEQICKHKWM 259
D R S+E++ H W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 183 bits (465), Expect = 8e-46
Identities = 100/264 (37%), Positives = 163/264 (61%), Gaps = 13/264 (4%)
Query: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPH 66
Y + +GKG++A VK A K VA+KIID+ + + +++ RE+ I+ + H
Sbjct: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGS 71
Query: 67 IIRLYQVMET-ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 125
II+ Y++ ET + IY++ E G++ + + G + E AR+ F+Q+ +AV +CH +
Sbjct: 72 IIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLD 131
Query: 126 IVHRDLKAENLLLDANLNIKIADFGFSNLF---TPGQLL--KTWCGSPPYAAPELFEGKE 180
IVHRDLK ENLLLD + NIK++DFGFS + G+++ KT+CGS YAAPE+ +
Sbjct: 132 IVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIP 191
Query: 181 YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF----FMSTECEHLI 236
Y DIWSLGV+LY++VCG++P+D S ++ + + + R+ F ++ EC+ LI
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLI 249
Query: 237 RHMLVLDPNKRLSMEQICKHKWMK 260
ML D ++RL +++I H W++
Sbjct: 250 YRMLQPDVSQRLHIDEILSHSWLQ 273
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 179 bits (453), Expect = 2e-44
Identities = 105/294 (35%), Positives = 168/294 (57%), Gaps = 26/294 (8%)
Query: 7 YYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPH 66
+YE R IG GNFAVVK H T+ A+KIIDK++L + + E+ I++ L HP+
Sbjct: 355 HYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKE-DMVDSEILIIQSLSHPN 413
Query: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
I++L++V ET+ IYL+ EY GG++FD ++ + E +A + A+ H ++I
Sbjct: 414 IVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSI 473
Query: 127 VHRDLKAENLLL----DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD 182
VHRDLK ENLL+ D + +K+ADFG + + + T CG+P Y APE+ K Y
Sbjct: 474 VHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVV--RPIFTVCGTPTYVAPEILSEKGY- 530
Query: 183 GPKVDIWSLGVVLYVLVCGALPF-----DGSTLQNLRARVLSGKFRIPFF--MSTECEHL 235
G +VD+W+ GV+LY+L+CG PF D L N+ ++ +F P++ +S + L
Sbjct: 531 GLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNI-IQLGHFEFLPPYWDNISDAAKDL 589
Query: 236 IRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNE 289
+ +LV+DP KR + Q+ +H W++ + +K ++QV P +E
Sbjct: 590 VSRLLVVDPKKRYTAHQVLQHPWIETA----------GKTNTVKRQKQVSPSSE 633
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,728,541
Number of Sequences: 37866
Number of extensions: 2959922
Number of successful extensions: 24226
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 811
Number of HSP's successfully gapped in prelim test: 428
Number of HSP's that attempted gapping in prelim test: 14123
Number of HSP's gapped (non-prelim): 5058
length of query: 1263
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1149
effective length of database: 13,930,794
effective search space: 16006482306
effective search space used: 16006482306
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.