Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 38569460
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38569460 SNF1-like kinase 2 [Homo sapiens]
(926 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 1868 0.0
gi|116256471 SNF1-like kinase [Homo sapiens] 588 e-168
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 461 e-129
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 357 3e-98
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 357 3e-98
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 357 4e-98
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 357 4e-98
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 357 4e-98
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 355 1e-97
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 354 2e-97
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 354 2e-97
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 354 2e-97
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 353 5e-97
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 351 2e-96
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 291 1e-78
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 290 3e-78
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 290 4e-78
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 289 7e-78
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 280 3e-75
gi|156105707 SNF related kinase [Homo sapiens] 273 7e-73
gi|156105705 SNF related kinase [Homo sapiens] 273 7e-73
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 265 1e-70
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 238 1e-62
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 234 4e-61
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 226 8e-59
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 197 3e-50
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 196 6e-50
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 185 1e-46
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 183 6e-46
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 181 4e-45
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 1868 bits (4840), Expect = 0.0
Identities = 926/926 (100%), Positives = 926/926 (100%)
Query: 1 MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN 60
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN
Sbjct: 1 MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN 60
Query: 61 LEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEAR 120
LEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEAR
Sbjct: 61 LEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEAR 120
Query: 121 RKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSP 180
RKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSP
Sbjct: 121 RKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSP 180
Query: 181 PYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFM 240
PYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFM
Sbjct: 181 PYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFM 240
Query: 241 SEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQV 300
SEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQV
Sbjct: 241 SEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQV 300
Query: 301 LRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTI 360
LRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTI
Sbjct: 301 LRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTI 360
Query: 361 AEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDT 420
AEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDT
Sbjct: 361 AEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDT 420
Query: 421 PKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQ 480
PKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQ
Sbjct: 421 PKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQ 480
Query: 481 RRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIML 540
RRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIML
Sbjct: 481 RRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIML 540
Query: 541 ANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQ 600
ANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQ
Sbjct: 541 ANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQ 600
Query: 601 HLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVST 660
HLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVST
Sbjct: 601 HLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVST 660
Query: 661 LPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQK 720
LPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQK
Sbjct: 661 LPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQK 720
Query: 721 RLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEP 780
RLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEP
Sbjct: 721 RLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEP 780
Query: 781 SSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPA 840
SSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPA
Sbjct: 781 SSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPA 840
Query: 841 PLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLAL 900
PLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLAL
Sbjct: 841 PLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLAL 900
Query: 901 SELPGLFDCEMLDAVDPQHNGYVLVN 926
SELPGLFDCEMLDAVDPQHNGYVLVN
Sbjct: 901 SELPGLFDCEMLDAVDPQHNGYVLVN 926
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 588 bits (1516), Expect = e-168
Identities = 344/682 (50%), Positives = 442/682 (64%), Gaps = 49/682 (7%)
Query: 11 QRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQI 70
Q+ P+RVGFYDIE TLGKGNFAVVKL RHR+TKT+VAIKIIDK++LD+ NLEKIYREVQ+
Sbjct: 18 QQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQL 77
Query: 71 MKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAV 130
MK+L+HPHIIKLYQVMETK MLY+VTE+AKNGE+FDYL ++G L+E+EAR+KFWQILSAV
Sbjct: 78 MKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAV 137
Query: 131 DYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEG 190
+YCH IVHRDLK ENLLLD NM+IK+ADFGFGNF+KSGE L+TWCGSPPYAAPEVFEG
Sbjct: 138 EYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEG 197
Query: 191 QQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRR 250
++YEGPQLDIWS+GVVLYVLVCG+LPFDGP LP LRQRVLEGRFRIP+FMS+DCE LIRR
Sbjct: 198 KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRR 257
Query: 251 MLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPS-IGEFNEQVLRLMHSLGI 309
MLV+DP++R+TIAQI++H+WM E + P + S +G+++EQ L +M +LG+
Sbjct: 258 MLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGV 317
Query: 310 DQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQ 369
D+Q+T+ESLQN SYNHFAAIY+LL+ERLK +R++ + RP + +
Sbjct: 318 DRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNA---------QCARPGPARQPRPRSSD 368
Query: 370 TVGLPVTMHSPNMRLLRSALL-PQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLL 428
GL V + R ALL PQ + A E +C + L
Sbjct: 369 LSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQA----------EMDCELQSSLQWPLF 418
Query: 429 DPVPPVL--VRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLS 486
PV V + PS++++T+I E +G E+ E+ S S RRHTL+
Sbjct: 419 FPVDASCSGVFRPRPVSPSSLLDTAISEEAR-QGPGLEEEQDTQESLPS--STGRRHTLA 475
Query: 487 EVTNQLVVMPGAGKIFSMND--SPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQP 544
EV+ +L + + S + SP+ + S + L P+ + ++ A P
Sbjct: 476 EVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSP 535
Query: 545 SPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQN 604
R+ SPF+ + P +QA V PVSF+EGRRASDTSLTQG+ AFRQ L+
Sbjct: 536 -VRLASPFLGSQSATPVLQAQGGLGGAV--LLPVSFQEGRRASDTSLTQGLKAFRQQLRK 592
Query: 605 LARTKGILELNKVQLLYEQI--GPEA-------DPNLAPA-APQLQDLASSCPQ-----E 649
RTKG L LNK++ L Q+ P + P APA +P L A+ + E
Sbjct: 593 TTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLE 652
Query: 650 EVSQQQESVSTLPASVHPQLSP 671
EV +QQ L HP +P
Sbjct: 653 EVLEQQR---LLQLQHHPAAAP 671
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 461 bits (1185), Expect = e-129
Identities = 323/871 (37%), Positives = 441/871 (50%), Gaps = 158/871 (18%)
Query: 14 PVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKM 73
P R+G+Y+I+ T+GKGNFAVVK H +TK +VAIKIIDK+QLD NL+KI+REVQIMKM
Sbjct: 2 PARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKM 61
Query: 74 LDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYC 133
L HPHII+LYQVMET+ M+YLVTEYA GEIFD+L HGR+ E EARRKF QI++AV +C
Sbjct: 62 LCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFC 121
Query: 134 HGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQY 193
H R IVHRDLKAENLLLD N+NIKIADFGF N F G+LL TWCGSPPYAAPE+FEG++Y
Sbjct: 122 HCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEY 181
Query: 194 EGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLV 253
+GP++DIWS+GVVLYVLVCGALPFDG TL LR RVL G+FRIP+FMS +CEHLIR MLV
Sbjct: 182 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLV 241
Query: 254 LDPSKRLTIAQIKEHKWMLI---EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGID 310
LDP+KRL++ QI +HKWM + + R + Q+ + E + NE VL M +G+D
Sbjct: 242 LDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD 301
Query: 311 QQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT 370
+++T++SL++ +Y+H++AIY LL +R K H++
Sbjct: 302 KEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKT---------------------------- 333
Query: 371 VGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDP 430
LR LP AF P + QAE A + P+V L++P
Sbjct: 334 --------------LRLGALPSMPRALAFQAPVN-IQAEQAGTAMN-ISVPQVQ--LINP 375
Query: 431 VPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTN 490
++ G +L S+ E EE A + S RRHT+
Sbjct: 376 ENQIVEPDGTLNLDSD--------------EGEEPSPEALVRYLS----MRRHTVGVADP 417
Query: 491 QLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTS 550
+ VM K+ P V+ + V ++NF+ + ++++ Q + S
Sbjct: 418 RTEVMEDLQKLL-----PGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQS 472
Query: 551 PFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKG 610
L+P P +Q L+ P+ GRRASD
Sbjct: 473 ---LLQP--PTLQLLNGM-------GPL----GRRASDGGAN------------------ 498
Query: 611 ILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPAS--VH-- 666
++L+ QLL GP + PA P + + E Q+ ST S +H
Sbjct: 499 -IQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLP 557
Query: 667 -PQLSPRQ-----SLETQYLQHRLQK---PSLLSKAQNTCQLYCKEPPRSLEQQLQEHRL 717
+ SP + + Q + L+K S + + Q C+ K ++++ E
Sbjct: 558 TERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQ 617
Query: 718 QQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPV 777
QQ L+ Q+Q QI + QQ+ Q++ P Q +PP P
Sbjct: 618 QQHMLYQQEQHH--------QILQ-------QQI----QDSICPPQPSPPLQAACENQPA 658
Query: 778 LEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGA 837
L Q Q +++QP S P P +Q PPP QP
Sbjct: 659 L-----------LTHQLQRLRIQP----SSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHG 703
Query: 838 APAPLQFSYQTCELPSAASPAPDYPTPCQYP 868
A + QF LPS ++ P C P
Sbjct: 704 AASSSQFQ----GLPSRSAIFQQQPENCSSP 730
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 357 bits (916), Expect = 3e-98
Identities = 201/437 (45%), Positives = 276/437 (63%), Gaps = 23/437 (5%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYLV EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
SKR T+ QI + +WM + E +P + P +P E LM S+G +++
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 342
Query: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT---- 370
+SL + YN A Y LL ++SS E D +P A+ T + A +
Sbjct: 343 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 394
Query: 371 VGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDP 430
V V+ + R A P ++S AE EE+ K + P
Sbjct: 395 VQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 454
Query: 431 VPPV--LVRKGCQSLPS 445
P+ L RK PS
Sbjct: 455 ASPLPGLERKKTTPTPS 471
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 357 bits (916), Expect = 3e-98
Identities = 201/437 (45%), Positives = 276/437 (63%), Gaps = 23/437 (5%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYLV EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
SKR T+ QI + +WM + E +P + P +P E LM S+G +++
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 342
Query: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT---- 370
+SL + YN A Y LL ++SS E D +P A+ T + A +
Sbjct: 343 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 394
Query: 371 VGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDP 430
V V+ + R A P ++S AE EE+ K + P
Sbjct: 395 VQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVP 454
Query: 431 VPPV--LVRKGCQSLPS 445
P+ L RK PS
Sbjct: 455 ASPLPGLERKKTTPTPS 471
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 357 bits (915), Expect = 4e-98
Identities = 200/436 (45%), Positives = 274/436 (62%), Gaps = 22/436 (5%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYLV EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
SKR T+ QI + +WM + E +P + P +P E LM S+G +++
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 342
Query: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLP 374
+SL + YN A Y LL ++SS E D +P A+ T + A +
Sbjct: 343 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 394
Query: 375 V---TMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPV 431
V +P R P ++S AE EE+ K + P
Sbjct: 395 VQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPA 454
Query: 432 PPV--LVRKGCQSLPS 445
P+ L RK PS
Sbjct: 455 SPLPGLERKKTTPTPS 470
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 357 bits (915), Expect = 4e-98
Identities = 200/436 (45%), Positives = 274/436 (62%), Gaps = 22/436 (5%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 109
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYLV EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 110 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 170 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 289
Query: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
SKR T+ QI + +WM + E +P + P +P E LM S+G +++
Sbjct: 290 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 342
Query: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLP 374
+SL + YN A Y LL ++SS E D +P A+ T + A +
Sbjct: 343 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 394
Query: 375 V---TMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPV 431
V +P R P ++S AE EE+ K + P
Sbjct: 395 VQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPA 454
Query: 432 PPV--LVRKGCQSLPS 445
P+ L RK PS
Sbjct: 455 SPLPGLERKKTTPTPS 470
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 357 bits (915), Expect = 4e-98
Identities = 200/436 (45%), Positives = 274/436 (62%), Gaps = 22/436 (5%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVA+KIIDK+QL++ +L+K++REV+IMK+L+H
Sbjct: 17 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 76
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYLV EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 77 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 137 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 196
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L+++ L+L+P
Sbjct: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNP 256
Query: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
SKR T+ QI + +WM + E +P + P +P E LM S+G +++
Sbjct: 257 SKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE-------LMVSMGYTREEI 309
Query: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLP 374
+SL + YN A Y LL ++SS E D +P A+ T + A +
Sbjct: 310 QDSLVGQRYNEVMATYLLL-----GYKSS---ELEGDTITLKPRPSADLTNSSAPSPSHK 361
Query: 375 V---TMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPV 431
V +P R P ++S AE EE+ K + P
Sbjct: 362 VQRSVSANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPA 421
Query: 432 PPV--LVRKGCQSLPS 445
P+ L RK PS
Sbjct: 422 SPLPGLERKKTTPTPS 437
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 355 bits (910), Expect = 1e-97
Identities = 176/327 (53%), Positives = 238/327 (72%), Gaps = 5/327 (1%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVAIKIIDK+QL+ +L+K++REV+IMK+L+H
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYL+ EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
+IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L++R LVL+P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 257 SKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316
KR T+ QI + +W I + L P EP + +++ + +M +G Q++ E
Sbjct: 293 IKRGTLEQIMKDRW--INAGHEEDELKPFV---EPELDISDQKRIDIMVGMGYSQEEIQE 347
Query: 317 SLQNKSYNHFAAIYFLLVERLKSHRSS 343
SL Y+ A Y LL + R S
Sbjct: 348 SLSKMKYDEITATYLLLGRKSSEVRPS 374
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 354 bits (908), Expect = 2e-97
Identities = 174/317 (54%), Positives = 235/317 (74%), Gaps = 5/317 (1%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVAIKIIDK+QL+ +L+K++REV+IMK+L+H
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYL+ EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
+IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L++R LVL+P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 257 SKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316
KR T+ QI + +W I + L P EP + +++ + +M +G Q++ E
Sbjct: 293 IKRGTLEQIMKDRW--INAGHEEDELKPFV---EPELDISDQKRIDIMVGMGYSQEEIQE 347
Query: 317 SLQNKSYNHFAAIYFLL 333
SL Y+ A Y LL
Sbjct: 348 SLSKMKYDEITATYLLL 364
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 354 bits (908), Expect = 2e-97
Identities = 174/317 (54%), Positives = 235/317 (74%), Gaps = 5/317 (1%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVAIKIIDK+QL+ +L+K++REV+IMK+L+H
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYL+ EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
+IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L++R LVL+P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 257 SKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316
KR T+ QI + +W I + L P EP + +++ + +M +G Q++ E
Sbjct: 293 IKRGTLEQIMKDRW--INAGHEEDELKPFV---EPELDISDQKRIDIMVGMGYSQEEIQE 347
Query: 317 SLQNKSYNHFAAIYFLL 333
SL Y+ A Y LL
Sbjct: 348 SLSKMKYDEITATYLLL 364
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 354 bits (908), Expect = 2e-97
Identities = 174/317 (54%), Positives = 235/317 (74%), Gaps = 5/317 (1%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y + T+GKGNFA VKL RH +T EVAIKIIDK+QL+ +L+K++REV+IMK+L+H
Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYL+ EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
+IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 173 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L++R LVL+P
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNP 292
Query: 257 SKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316
KR T+ QI + +W I + L P EP + +++ + +M +G Q++ E
Sbjct: 293 IKRGTLEQIMKDRW--INAGHEEDELKPFV---EPELDISDQKRIDIMVGMGYSQEEIQE 347
Query: 317 SLQNKSYNHFAAIYFLL 333
SL Y+ A Y LL
Sbjct: 348 SLSKMKYDEITATYLLL 364
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 353 bits (905), Expect = 5e-97
Identities = 176/319 (55%), Positives = 234/319 (73%), Gaps = 9/319 (2%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
VG Y + T+GKGNFA VKL RH +T EVAIKIIDK+QL+ +L+K++REV+IMK L+H
Sbjct: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 115
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYLV EYA GE+FDYL +HGR+ E EAR KF QI+SAV YCH +
Sbjct: 116 PNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
IVHRDLKAENLLLD NIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 176 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++DIWS+GV+LY LV G+LPFDG L LR+RVL G++R+P++MS DCE ++RR LVL+P
Sbjct: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295
Query: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
+KR T+ QI + KW+ I E +P P+E + + + +M +G +++
Sbjct: 296 AKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGD-------TKRIEVMVGMGYTREEI 348
Query: 315 IESLQNKSYNHFAAIYFLL 333
ESL ++ YN A Y LL
Sbjct: 349 KESLTSQKYNEVTATYLLL 367
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 351 bits (900), Expect = 2e-96
Identities = 170/319 (53%), Positives = 237/319 (74%), Gaps = 9/319 (2%)
Query: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
+G Y ++ T+GKGNFA VKL RH +T EVA+KIIDK+QL+ +L+K++REV+IMK+L+H
Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNH 116
Query: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
P+I+KL++V+ET+ LYLV EYA GE+FDYL HGR+ E EAR KF QI+SAV YCH +
Sbjct: 117 PNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 176
Query: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
IVHRDLKAENLLLD +MNIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 177 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 236
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
++D+WS+GV+LY LV G+LPFDG L LR+RVL G++RIP++MS DCE+L++++LVL+P
Sbjct: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 296
Query: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
KR ++ QI + +WM + E +P P N+ + + +M ++G + +
Sbjct: 297 IKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFND-------TKRIDIMVTMGFARDEI 349
Query: 315 IESLQNKSYNHFAAIYFLL 333
++L N+ Y+ A Y LL
Sbjct: 350 NDALINQKYDEVMATYILL 368
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 291 bits (746), Expect = 1e-78
Identities = 154/360 (42%), Positives = 223/360 (61%), Gaps = 13/360 (3%)
Query: 6 GPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY 65
G +H Q VG Y +E TLGKG +VKLG H +T +VAIKI+++ +L L K+
Sbjct: 9 GAQHAQY----VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVE 64
Query: 66 REVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQ 125
RE+ I+K+++HPH++KL+ V E K LYLV E+ GE+FDYL GRL EAR+ F Q
Sbjct: 65 REIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQ 124
Query: 126 ILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAP 185
I+SA+D+CH I HRDLK ENLLLD NI+IADFG + LL T CGSP YA P
Sbjct: 125 IISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACP 184
Query: 186 EVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCE 245
EV G++Y+G + D+WS GV+L+ L+ GALPFD L L ++V G F +P+F+ DC+
Sbjct: 185 EVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQ 244
Query: 246 HLIRRMLVLDPSKRLTIAQIKEHKWML---IEVPVQRPVLYPQEQENEPSIGEFNEQVLR 302
L+R M+ +D ++RLT+ I++H W + E ++P+ + + PS+ + + VL
Sbjct: 245 SLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLD 304
Query: 303 LMHSLGI--DQQKTIESLQNKSYNHFAAIYFLLVERLKSHRS----SFPVEQRLDGRQRR 356
MHSLG D+ K ++ L ++ N IYFLL++R + + S P +D ++R
Sbjct: 305 SMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKR 364
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 290 bits (743), Expect = 3e-78
Identities = 143/335 (42%), Positives = 216/335 (64%), Gaps = 6/335 (1%)
Query: 3 MADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE 62
MA + G V++G Y + TLG G F VK+G+H +T +VA+KI+++ ++ ++++
Sbjct: 10 MATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVV 69
Query: 63 -KIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARR 121
KI RE+Q +K+ HPHIIKLYQV+ T S +++V EY GE+FDY+ +GRL+E E+RR
Sbjct: 70 GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRR 129
Query: 122 KFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPP 181
F QILS VDYCH +VHRDLK EN+LLD +MN KIADFG N GE L T CGSP
Sbjct: 130 LFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 189
Query: 182 YAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMS 241
YAAPEV G+ Y GP++DIWS GV+LY L+CG LPFD +P L +++ +G F P +++
Sbjct: 190 YAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLN 249
Query: 242 EDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVL 301
L++ ML +DP KR TI I+EH+W ++P L+P++ ++ + +E +
Sbjct: 250 PSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP---KYLFPEDPSYSSTMID-DEALK 305
Query: 302 RLMHSLGIDQQKTIESLQNKSY-NHFAAIYFLLVE 335
+ +++ + L N+++ + A Y L+++
Sbjct: 306 EVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIID 340
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 290 bits (742), Expect = 4e-78
Identities = 150/346 (43%), Positives = 218/346 (63%), Gaps = 10/346 (2%)
Query: 3 MADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE 62
MA+ +H G V++G Y + TLG G F VK+G H++T +VA+KI+++ ++ ++++
Sbjct: 1 MAEKQKH--DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV 58
Query: 63 -KIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARR 121
KI RE+Q +K+ HPHIIKLYQV+ T + ++V EY GE+FDY+ HGR+ E EARR
Sbjct: 59 GKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR 118
Query: 122 KFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPP 181
F QILSAVDYCH +VHRDLK EN+LLD +MN KIADFG N GE L T CGSP
Sbjct: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 178
Query: 182 YAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMS 241
YAAPEV G+ Y GP++DIWS GV+LY L+CG LPFD +P L +++ G F IP +++
Sbjct: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238
Query: 242 EDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVL 301
L+ ML +DP KR TI I+EH+W ++P L+P++ + ++ + +E V
Sbjct: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP---SYLFPEDPSYDANVID-DEAVK 294
Query: 302 RLMHSLGIDQQKTIESL-QNKSYNHFAAIYFLLVE--RLKSHRSSF 344
+ + + + SL + A Y L+++ R+ + S F
Sbjct: 295 EVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEF 340
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 289 bits (740), Expect = 7e-78
Identities = 154/343 (44%), Positives = 215/343 (62%), Gaps = 11/343 (3%)
Query: 7 PRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYR 66
P+H Q VG Y +E TLGKG +VKLG H IT +VAIKI+++ +L L K+ R
Sbjct: 25 PQHAQY----VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVER 80
Query: 67 EVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQI 126
E+ I+K+++HPH++KL+ V E K LYLV E+ GE+FDYL GRL EAR+ F QI
Sbjct: 81 EIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQI 140
Query: 127 LSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPE 186
+SA+D+CH I HRDLK ENLLLD NI+IADFG + LL T CGSP YA PE
Sbjct: 141 VSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPE 200
Query: 187 VFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEH 246
V +G++Y+G + D+WS GV+L+ L+ GALPFD L L ++V G F +P+F+ DC+
Sbjct: 201 VIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS 260
Query: 247 LIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQ-----EQENEPSIGEFNEQVL 301
L+R M+ ++P KRL++ QI++H W L P L P + PS GE + VL
Sbjct: 261 LLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVL 320
Query: 302 RLMHSLGI--DQQKTIESLQNKSYNHFAAIYFLLVERLKSHRS 342
M SLG D+++ L+++ N IY+LL++R + + S
Sbjct: 321 ESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPS 363
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 280 bits (717), Expect = 3e-75
Identities = 143/350 (40%), Positives = 216/350 (61%), Gaps = 21/350 (6%)
Query: 3 MADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE 62
MA + G V++G Y + TLG G F VK+G+H +T +VA+KI+++ ++ ++++
Sbjct: 10 MATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVV 69
Query: 63 -KIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGR-------- 113
KI RE+Q +K+ HPHIIKLYQV+ T S +++V EY GE+FDY+ +GR
Sbjct: 70 GKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVV 129
Query: 114 -------LNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNF 166
L+E E+RR F QILS VDYCH +VHRDLK EN+LLD +MN KIADFG N
Sbjct: 130 KTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM 189
Query: 167 FKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILR 226
GE L T CGSP YAAPEV G+ Y GP++DIWS GV+LY L+CG LPFD +P L
Sbjct: 190 MSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLF 249
Query: 227 QRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQE 286
+++ +G F P +++ L++ ML +DP KR TI I+EH+W ++P L+P++
Sbjct: 250 KKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP---KYLFPED 306
Query: 287 QENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSY-NHFAAIYFLLVE 335
++ + +E + + +++ + L N+++ + A Y L+++
Sbjct: 307 PSYSSTMID-DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIID 355
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 273 bits (697), Expect = 7e-73
Identities = 173/510 (33%), Positives = 270/510 (52%), Gaps = 30/510 (5%)
Query: 18 GFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHP 77
G YD++ TLG+G+FAVVKL RH T +VA+K+IDK++LD + +++EV+ MK++ HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 78 HIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGR-LNESEARRKFWQILSAVDYCHGR 136
+I++LY+V++T++ LYL+ E G++FDY+ H LNE A++ F QI+ A+ YCH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 137 KIVHRDLKAENLLLDNNMN-IKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEG 195
+VHRDLK EN++ +K+ DFGF N F+ G+ L T CGS Y+APE+ G +Y+
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 196 PQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLD 255
P +DIWS+GV+L++LVCG PF +++ ++ +P +S++C+ LI RML D
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 256 PSKRLTIAQIKEHKWML-IEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
P +R ++ +I+ H W+ ++ P S E N + R++ D+
Sbjct: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAI 313
Query: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT-VGL 373
+E+L+ YNH A YFLL ER+ + E+ + R PS I Q T + +
Sbjct: 314 VEALETNRYNHITATYFLLAERILREKQ----EKEIQTRSASPSNIKAQFRQSWPTKIDV 369
Query: 374 PVTMHSP-NMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVP 432
P + L A +PQ S A +G +++ + D P++ G L VP
Sbjct: 370 PQDLEDDLTATPLSHATVPQ-SPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVP 428
Query: 433 PVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQL 492
P ++ P+ + E E E EED ST+ RR VTN+L
Sbjct: 429 PASLK------PTASGRKCLFRVEEDEEEDEEDKK---PMSLSTQVVLRRK--PSVTNRL 477
Query: 493 V---VMPGAGKIFSMNDSPSLDSVDSEYDM 519
P +IF +S D E+DM
Sbjct: 478 TSRKSAPVLNQIFEEGES------DDEFDM 501
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 273 bits (697), Expect = 7e-73
Identities = 173/510 (33%), Positives = 270/510 (52%), Gaps = 30/510 (5%)
Query: 18 GFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHP 77
G YD++ TLG+G+FAVVKL RH T +VA+K+IDK++LD + +++EV+ MK++ HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 78 HIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGR-LNESEARRKFWQILSAVDYCHGR 136
+I++LY+V++T++ LYL+ E G++FDY+ H LNE A++ F QI+ A+ YCH
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 137 KIVHRDLKAENLLLDNNMN-IKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEG 195
+VHRDLK EN++ +K+ DFGF N F+ G+ L T CGS Y+APE+ G +Y+
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 196 PQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLD 255
P +DIWS+GV+L++LVCG PF +++ ++ +P +S++C+ LI RML D
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 256 PSKRLTIAQIKEHKWML-IEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
P +R ++ +I+ H W+ ++ P S E N + R++ D+
Sbjct: 254 PKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAI 313
Query: 315 IESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQT-VGL 373
+E+L+ YNH A YFLL ER+ + E+ + R PS I Q T + +
Sbjct: 314 VEALETNRYNHITATYFLLAERILREKQ----EKEIQTRSASPSNIKAQFRQSWPTKIDV 369
Query: 374 PVTMHSP-NMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVP 432
P + L A +PQ S A +G +++ + D P++ G L VP
Sbjct: 370 PQDLEDDLTATPLSHATVPQ-SPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVP 428
Query: 433 PVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQL 492
P ++ P+ + E E E EED ST+ RR VTN+L
Sbjct: 429 PASLK------PTASGRKCLFRVEEDEEEDEEDKK---PMSLSTQVVLRRK--PSVTNRL 477
Query: 493 V---VMPGAGKIFSMNDSPSLDSVDSEYDM 519
P +IF +S D E+DM
Sbjct: 478 TSRKSAPVLNQIFEEGES------DDEFDM 501
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 265 bits (677), Expect = 1e-70
Identities = 140/346 (40%), Positives = 213/346 (61%), Gaps = 7/346 (2%)
Query: 16 RVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLD 75
R+GFY I G +G GNF+ VKLG H +TK +VAIKI+DK++LD + RE+ M+ L
Sbjct: 70 RIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLH 129
Query: 76 HPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHG 135
HP+II+LY+V+ET S L+LV EYA GE+F ++ G+L+E E++ F QI+SAV + H
Sbjct: 130 HPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHE 189
Query: 136 RKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEG 195
+I+HRDLKAEN+ +N +K+ DFGF K GE+L T+CGSPPYAAPE+F + Y G
Sbjct: 190 NQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIG 249
Query: 196 PQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLD 255
+DIW++GV+LY +V G +PF T+ L++ +LEG + +P +SE C LIR +L
Sbjct: 250 IYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQI 309
Query: 256 PSKRLTIAQIKEHKWMLIEVPVQRPV----LYPQEQENEPSIGEFNEQVLRLMHSLGIDQ 311
P++R I I +WM VP P+ L P+ ++ E +V + LGI +
Sbjct: 310 PTERYGIDCIMNDEWMQ-GVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITE 368
Query: 312 QKTIESLQNKSYNHFAAIYFLLVERLKSHRS--SFPVEQRLDGRQR 355
+ + + + +Y +++ R++ ++ S PV D ++R
Sbjct: 369 EHIRNNQGRDARSSITGVYRIILHRVQRKKALESVPVMMLPDPKER 414
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 238 bits (608), Expect = 1e-62
Identities = 117/253 (46%), Positives = 165/253 (65%), Gaps = 2/253 (0%)
Query: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL-DAVNLEKIYREVQIMKMLDHPH 78
Y+++ TLGKG + VK R + VAIK I K ++ D ++ I RE++IM L+HPH
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138
II +Y+V E K + ++ EYA GE++DY++ RL+E E R F QI+SAV YCH +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQL 198
VHRDLK EN+LLD+N NIKIADFG N ++ + L T+CGSP YA+PE+ G+ Y GP++
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 199 DIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSK 258
D W++GV+LY LV G +PFDG L +++ G +R P D LIR ML+++P +
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
Query: 259 RLTIAQIKEHKWM 271
R TI I H W+
Sbjct: 294 RATIEDIANHWWV 306
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 234 bits (596), Expect = 4e-61
Identities = 118/253 (46%), Positives = 169/253 (66%), Gaps = 3/253 (1%)
Query: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL-DAVNLEKIYREVQIMKMLDHPH 78
Y+ TLGKG + VK R + VAIK I K ++ D +L I RE++IM L+HPH
Sbjct: 53 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138
II +++V E S + +V EYA G+++DY++ +L+E EAR F QI+SAV YCH ++
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171
Query: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQL 198
VHRDLK EN+LLD N NIKIADFG N + G+ L T+CGSP YA+PE+ G+ Y GP++
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 199 DIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSK 258
D WS+GV+LY+LV G +PFDG IL +++ G +R P S+ C LIR +L+++P++
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290
Query: 259 RLTIAQIKEHKWM 271
R T+ + H W+
Sbjct: 291 RATLEDVASHWWV 303
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 226 bits (576), Expect = 8e-59
Identities = 121/321 (37%), Positives = 192/321 (59%), Gaps = 10/321 (3%)
Query: 19 FYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPH 78
+Y++ T+G G FA VKL H +T VAIKI+DK+ L + +L +I E++ +K L H H
Sbjct: 10 YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-DLPRIKTEIEALKNLRHQH 68
Query: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138
I +LY V+ET + +++V EY GE+FDY+ + RL+E E R F QI+SAV Y H +
Sbjct: 69 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128
Query: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSGE--LLATWCGSPPYAAPEVFEGQQYEGP 196
HRDLK ENLL D +K+ DFG K + L T CGS YAAPE+ +G+ Y G
Sbjct: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
Query: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
+ D+WSMG++LYVL+CG LPFD + L ++++ G++ +P ++S L+++ML +DP
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
Query: 257 SKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316
KR+++ + H W + + YP E +++ ++ + + + ++T+E
Sbjct: 249 KKRISMKNLLNHPW------IMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTME 302
Query: 317 SLQNK-SYNHFAAIYFLLVER 336
L + Y+H A Y LL+ +
Sbjct: 303 DLISLWQYDHLTATYLLLLAK 323
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 197 bits (502), Expect = 3e-50
Identities = 108/255 (42%), Positives = 155/255 (60%), Gaps = 9/255 (3%)
Query: 26 LGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPHIIKLYQ 84
LG+G++A VK K VAIKIID+ + A LEK RE++I+ ML+H IIK Y+
Sbjct: 18 LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYE 77
Query: 85 VMETK-SMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDL 143
+ ET +Y+V E A G++ + + G L+E EAR+KF Q+ A+ YCH +VHRDL
Sbjct: 78 IFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDL 137
Query: 144 KAENLLLDNNMNIKIADFGFGNFFKSGE-----LLATWCGSPPYAAPEVFEGQQYEGPQL 198
K +NLLLD + NIK++DF F + L T+CGSP YAAPEV +G Y+
Sbjct: 138 KCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVY 197
Query: 199 DIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIP--YFMSEDCEHLIRRMLVLDP 256
DIWS+GV+LY++VCG++P+D + + + E R P ++ +C+ LI ML D
Sbjct: 198 DIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDV 257
Query: 257 SKRLTIAQIKEHKWM 271
++RL I +I H WM
Sbjct: 258 NRRLHIDEILSHCWM 272
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 196 bits (499), Expect = 6e-50
Identities = 127/341 (37%), Positives = 190/341 (55%), Gaps = 21/341 (6%)
Query: 16 RVGFYDIEGT-LGKGNFAVVKLGRHRITKTEVAIKIIDKSQL--DAVNLEKIYREVQIMK 72
RVG Y I LG+G+FA V+ G H +T +VAIK+IDK + D + + RE QI +
Sbjct: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
Query: 73 MLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDY 132
M+ HP+I +L ++ET++ YLV E G + + RL ESEARR Q++SAV++
Sbjct: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
Query: 133 CHGRKIVHRDLKAENLLLDNNMNIKIADFGFGN---FFKSGELLATWCGSPPYAAPEVFE 189
H +VHRDLK ENLLLD + NIK+ DFG N + +T CGSP YAAPE+
Sbjct: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
Query: 190 GQQYEGPQLDIWSMGVVLYVLVCGALPF--DGPTLPILRQRVLEGRFR-IPYFMSEDCEH 246
++Y GP++D+WS+GV +Y ++ G LPF + +L L Q++++ +P +S
Sbjct: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
Query: 247 LIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRP--VLYPQE---QENEPSIGEFNEQVL 301
+R +L DP KR I Q ++W+ + P V YP ++ PS+ VL
Sbjct: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSV------VL 349
Query: 302 RLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRS 342
+ LG I ++ + H AIYFLL ++L+ + S
Sbjct: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLS 390
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 185 bits (470), Expect = 1e-46
Identities = 104/261 (39%), Positives = 155/261 (59%), Gaps = 9/261 (3%)
Query: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPH 78
Y + LGKG++A VK K VA+KIID+ + +E+ RE+ I+ ++H
Sbjct: 12 YIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGS 71
Query: 79 IIKLYQVMETKS-MLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRK 137
IIK Y++ ET +Y++ E G++ +++ G L+E AR+ F Q+ SAV YCH
Sbjct: 72 IIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLD 131
Query: 138 IVHRDLKAENLLLDNNMNIKIADFGFGNFF---KSGELL--ATWCGSPPYAAPEVFEGQQ 192
IVHRDLK ENLLLD + NIK++DFGF +G ++ T+CGS YAAPEV +
Sbjct: 132 IVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIP 191
Query: 193 YEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYF--MSEDCEHLIRR 250
Y+ DIWS+GV+LY++VCG++P+D + + + E R P ++ +C+ LI R
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYR 251
Query: 251 MLVLDPSKRLTIAQIKEHKWM 271
ML D S+RL I +I H W+
Sbjct: 252 MLQPDVSQRLHIDEILSHSWL 272
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 183 bits (465), Expect = 6e-46
Identities = 102/257 (39%), Positives = 157/257 (61%), Gaps = 6/257 (2%)
Query: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPH 78
Y + T+G+G ++ VK + + +VAIK+IDK +++ RE+QI++ LDH +
Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Query: 79 IIKLYQVMETKS-MLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRK 137
II++Y+++E+ + LV E A+ G++FD + N G L ES A+ F Q++ A+ YCHG
Sbjct: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
Query: 138 IVHRDLKAENLLLDNNMNIKIADFGFGNFFKSG--ELLATWCGSPPYAAPEVFEGQQYEG 195
+ HRDLK EN LL N+K+ DFGF EL T+CGS YAAPEV +G ++
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
Query: 196 PQLDIWSMGVVLYVLVCGALPFDGPTLP-ILRQRVLEGRFRIPYFMSEDCEHLIRRMLVL 254
+ D+WSMGVVLYV++C +LPFD +P +L Q+ F +S DC+ L++R+L
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
Query: 255 DPSKRLTIAQIKEHKWM 271
D R +I ++ H W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 181 bits (458), Expect = 4e-45
Identities = 109/298 (36%), Positives = 167/298 (56%), Gaps = 16/298 (5%)
Query: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI 79
Y+ +G GNFAVVK RHR T+ A+KIIDKS+L + + E+ I++ L HP+I
Sbjct: 356 YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKE-DMVDSEILIIQSLSHPNI 414
Query: 80 IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIV 139
+KL++V ET +YL+ EY + G++FD + + E +A + A+ + H + IV
Sbjct: 415 VKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIV 474
Query: 140 HRDLKAENLLL----DNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEG 195
HRDLK ENLL+ D + +K+ADFG + T CG+P Y APE+ + Y G
Sbjct: 475 HRDLKPENLLVQRNEDKSTTLKLADFGLAKHVV--RPIFTVCGTPTYVAPEILSEKGY-G 531
Query: 196 PQLDIWSMGVVLYVLVCGALPFDGP--TLPILRQRVLEGRFRI--PYF--MSEDCEHLIR 249
++D+W+ GV+LY+L+CG PF P L + G F PY+ +S+ + L+
Sbjct: 532 LEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVS 591
Query: 250 RMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSL 307
R+LV+DP KR T Q+ +H W IE + + Q+Q + S G F Q R++ +
Sbjct: 592 RLLVVDPKKRYTAHQVLQHPW--IETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQV 647
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,480,992
Number of Sequences: 37866
Number of extensions: 2451095
Number of successful extensions: 51854
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1369
Number of HSP's successfully gapped in prelim test: 1317
Number of HSP's that attempted gapping in prelim test: 19265
Number of HSP's gapped (non-prelim): 13377
length of query: 926
length of database: 18,247,518
effective HSP length: 112
effective length of query: 814
effective length of database: 14,006,526
effective search space: 11401312164
effective search space used: 11401312164
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.