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Search of human proteins with 38569428
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38569428 ankyrin repeat domain protein 5 [Homo sapiens]
(776 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38569428 ankyrin repeat domain protein 5 [Homo sapiens] 1566 0.0
gi|38569426 ankyrin repeat domain protein 5 [Homo sapiens] 1566 0.0
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 131 3e-30
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 131 3e-30
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 131 3e-30
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 112 2e-24
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 98 3e-20
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 97 6e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 94 4e-19
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 94 4e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 94 4e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 94 4e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 94 4e-19
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 93 1e-18
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 89 1e-17
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 89 2e-17
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 87 6e-17
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 87 8e-17
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 81 3e-15
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 81 3e-15
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 81 3e-15
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 81 3e-15
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 80 6e-15
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 80 9e-15
gi|118150656 ankyrin repeat domain 7 [Homo sapiens] 79 1e-14
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 79 1e-14
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 79 2e-14
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 79 2e-14
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 79 2e-14
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 79 2e-14
>gi|38569428 ankyrin repeat domain protein 5 [Homo sapiens]
Length = 776
Score = 1566 bits (4054), Expect = 0.0
Identities = 776/776 (100%), Positives = 776/776 (100%)
Query: 1 MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSND 60
MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSND
Sbjct: 1 MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSND 60
Query: 61 IDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFY 120
IDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFY
Sbjct: 61 IDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFY 120
Query: 121 CILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAI 180
CILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAI
Sbjct: 121 CILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAI 180
Query: 181 NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY 240
NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY
Sbjct: 181 NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY 240
Query: 241 NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAAS 300
NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAAS
Sbjct: 241 NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAAS 300
Query: 301 KEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV 360
KEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV
Sbjct: 301 KEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV 360
Query: 361 MVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGM 420
MVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGM
Sbjct: 361 MVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGM 420
Query: 421 GKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQD 480
GKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQD
Sbjct: 421 GKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQD 480
Query: 481 DSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDV 540
DSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDV
Sbjct: 481 DSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDV 540
Query: 541 VKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIE 600
VKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIE
Sbjct: 541 VKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIE 600
Query: 601 SCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 660
SCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK
Sbjct: 601 SCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 660
Query: 661 GKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITF 720
GKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITF
Sbjct: 661 GKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITF 720
Query: 721 IPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT 776
IPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT
Sbjct: 721 IPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT 776
>gi|38569426 ankyrin repeat domain protein 5 [Homo sapiens]
Length = 776
Score = 1566 bits (4054), Expect = 0.0
Identities = 776/776 (100%), Positives = 776/776 (100%)
Query: 1 MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSND 60
MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSND
Sbjct: 1 MALADKRLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSND 60
Query: 61 IDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFY 120
IDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFY
Sbjct: 61 IDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFY 120
Query: 121 CILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAI 180
CILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAI
Sbjct: 121 CILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAI 180
Query: 181 NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY 240
NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY
Sbjct: 181 NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY 240
Query: 241 NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAAS 300
NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAAS
Sbjct: 241 NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAAS 300
Query: 301 KEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV 360
KEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV
Sbjct: 301 KEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV 360
Query: 361 MVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGM 420
MVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGM
Sbjct: 361 MVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGM 420
Query: 421 GKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQD 480
GKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQD
Sbjct: 421 GKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQD 480
Query: 481 DSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDV 540
DSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDV
Sbjct: 481 DSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDV 540
Query: 541 VKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIE 600
VKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIE
Sbjct: 541 VKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIE 600
Query: 601 SCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 660
SCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK
Sbjct: 601 SCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 660
Query: 661 GKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITF 720
GKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITF
Sbjct: 661 GKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDITF 720
Query: 721 IPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT 776
IPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT
Sbjct: 721 IPRRIWSPEATTAELIRKRELRRERFTHEVDFDDFMMPFQKNITEKARALEAALKT 776
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 131 bits (329), Expect = 3e-30
Identities = 155/624 (24%), Positives = 261/624 (41%), Gaps = 65/624 (10%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG + L++A+ N ID+V +LL+ GA+ G TP A + GH ++ IL
Sbjct: 108 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL------ 161
Query: 107 MTIVDNEGKGVL---FYCILPTKRHYRCALIALE--HGADV------NNSTYEG-KPIFL 154
++N+ KG + I K + A + L+ H ADV N +T G P+ +
Sbjct: 162 ---LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218
Query: 155 RACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAF 214
A + +V L +GA + + G T L AS+ G +V+ +L+RGG+++A
Sbjct: 219 AA---HYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274
Query: 215 DNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
D H AA+ G +++LL + + NG +PLH AA G +C K++ Q
Sbjct: 275 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334
Query: 275 CDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPN---PLW------ 325
+ LD+ T VA G R + + +K A P A+ N PL
Sbjct: 335 APVDDVTLDYLTALHVAAHCG------HYRVTKLLLDKRANPNARALNGFTPLHIACKKN 388
Query: 326 ALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV----MVLEERQDYASSE--QLAAIA 379
+++ + V+ A ++ A+ + G I F+ +VL Q+ AS + +
Sbjct: 389 RIKVMELLVKYGASIQ---AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 445
Query: 380 HLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIP 439
LH R G V + R L ++ L ++++ + + GK + +
Sbjct: 446 ALHMAARAGQVEV------VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Query: 440 EYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINII 499
+ +G P + I + D + + H + ++K F+ +++
Sbjct: 500 AHPDAATTNGYTPLH-ISAREGQVDVASVLLEAGAAHSLA---------TKKGFTPLHVA 549
Query: 500 TKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLW 559
K G L K + D TPL A N V LLEKGA+ +AT +
Sbjct: 550 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 609
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQL 619
TPLH A Q I L+ GA + + TPL+ A + D V LLD GA +
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 669
Query: 620 ENRKGHSAMDVAKAYADYRIIDLI 643
+ G +++ +A + D++
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADIL 693
Score = 111 bits (278), Expect = 2e-24
Identities = 144/658 (21%), Positives = 239/658 (36%), Gaps = 99/658 (15%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG++ LH+AS + +MV LLD G D + R G TP AA GH+ +E+L + A
Sbjct: 244 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ G L + H C L+H A V+ DV
Sbjct: 304 LLARTKNGLSPLH--MAAQGDHVECVKHLLQHKAPVD---------------------DV 340
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L +L TAL A+ G + + +L++ NA + H A
Sbjct: 341 TLDYL---------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 385
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
K +++LL Y + I+ +G TP+H AA G + + Q G N+ +T
Sbjct: 386 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 445
Query: 287 PRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAV 346
+A G + + R + + AR E + L A
Sbjct: 446 ALHMAARAGQVEVVRCLLRNGALVDARAR-------------------EEQTPLHIA--- 483
Query: 347 LDRGDGSISKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSF 406
+ K + V +L + + + LH R G V++ L ++
Sbjct: 484 -----SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV------ASVLLEAG 532
Query: 407 VLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKN----- 461
S KK + K G + + A ++G P ++ Y N
Sbjct: 533 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 592
Query: 462 ------VTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVF-SNINIITKAG----------- 503
+ + + P H + I + + + NI+TK G
Sbjct: 593 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 652
Query: 504 --DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
D+ +L + G + M T L A ++V L + GA+ +A +TP
Sbjct: 653 HTDMVTL--LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 710
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L ACH G +V L++ GA ++A + N TPL++A + + LL GAK
Sbjct: 711 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 770
Query: 622 RKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGK-TPPILKTEGPEIKKEE 678
G++A+ +AK ++D +K + + K K P TE ++ EE
Sbjct: 771 ANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEE 828
Score = 76.6 bits (187), Expect = 8e-14
Identities = 58/193 (30%), Positives = 90/193 (46%), Gaps = 4/193 (2%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+E F+ ++I G++ G VD TPL A GN ++VK LL++G
Sbjct: 209 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
++A TPLH A +G +VELL+E GA + A + N +PL+ A + ++ VK
Sbjct: 269 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 328
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILK 668
+LL A +A+ VA YR+ L+ +K N + L G TP +
Sbjct: 329 HLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN----PNARALNGFTPLHIA 384
Query: 669 TEGPEIKKEEELL 681
+ IK E L+
Sbjct: 385 CKKNRIKVMELLV 397
Score = 75.1 bits (183), Expect = 2e-13
Identities = 61/223 (27%), Positives = 104/223 (46%), Gaps = 10/223 (4%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
+++ +AG + ++ +G VD + +TPL A G ++V+ LL+ A+ +A
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPLH + GQ D+ +L+E+GA A+ TPL+ A + LD K LL A
Sbjct: 507 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
Query: 616 KFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
+ G + + VA Y + ++ L+ EK + A+N G TP + + +++
Sbjct: 567 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN----GYTPLHIAAKKNQMQ 622
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDI 718
LL+ YG T V K V L+ G+T V +
Sbjct: 623 IASTLLN--YGAETNI----VTKQGVTPLHLASQEGHTDMVTL 659
Score = 72.8 bits (177), Expect = 1e-12
Identities = 48/158 (30%), Positives = 83/158 (52%), Gaps = 2/158 (1%)
Query: 490 EKVFSNINII--TKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEK 547
+K SN + + +AG+L + + + GI ++ + L A G++ +V+ LL +
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
Query: 548 GANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTV 607
G++V++ T LH A AGQ ++V++LV+ GA I+A S N TPL A + +D V
Sbjct: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 608 KYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKE 645
KYLL+ GA G + + VA + + ++ E
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 163
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/283 (24%), Positives = 115/283 (40%), Gaps = 38/283 (13%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NGL+ALHLA+ + +V LL G+ D + G T A+ G +++L K A+
Sbjct: 42 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 101
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAH----- 161
+ G L+ + + H LE+GA+ + +T +G A + H
Sbjct: 102 INAQSQNGFTPLY--MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 159
Query: 162 -----------------------DVKDVCLTFLEKGANPNA-----INSST--GRTALME 191
D K L L+ N + +N +T G T L
Sbjct: 160 ILLENDTKGKVRLPALHIAARKDDTKSAAL-LLQNDHNADVQSKMMVNRTTESGFTPLHI 218
Query: 192 ASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISING 251
A+ G V + +L RG V+ + H A+K G +++KLL G + + +G
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 252 NTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEG 294
TPLH AA G + + +RG L + + +P +A +G
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 321
Score = 67.4 bits (163), Expect = 5e-11
Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 3/147 (2%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
FLRA + D + +L+ G + N N + G AL A++EG V +V+ +L RG V+
Sbjct: 14 FLRAARAGN--LDKVVEYLKGGIDINTCNQN-GLNALHLAAKEGHVGLVQELLGRGSSVD 70
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ + A H A+ G +++K+L ++ S NG TPL+ AA D KY+ +
Sbjct: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130
Query: 273 RGCDLKWKNLDHKTPRAVAKEGGFKAA 299
G + D TP AVA + G A
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQA 157
Score = 66.2 bits (160), Expect = 1e-10
Identities = 71/276 (25%), Positives = 114/276 (41%), Gaps = 19/276 (6%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKA 105
+NG + LH+A N I ++ L+ GA G TP AA +GH + +L + A
Sbjct: 375 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434
Query: 106 DMTIVDNEGKGVLFYCILPTKRHY-RCALIALEHGADVN-NSTYEGKPIFLRACEDAHDV 163
+ + G+ L + RC L +GA V+ + E P+ + + ++
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEI 491
Query: 164 KDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAH 223
+ L + A+P+A ++ G T L ++REG V++ +LE G + H
Sbjct: 492 VQLLLQHM---AHPDAATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 547
Query: 224 FAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLD 283
AAK G D+ KLL NG TPLH AA + ++G
Sbjct: 548 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA-------- 599
Query: 284 HKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAK 319
+P A AK G + +IA+ L GA+
Sbjct: 600 --SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 633
Score = 65.5 bits (158), Expect = 2e-10
Identities = 60/233 (25%), Positives = 103/233 (44%), Gaps = 7/233 (3%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKA 105
I G +ALH+A+ + +++V LL GA D + R TP A+ LG +++L + A
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 500
Query: 106 DMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEG-KPIFLRACEDAHDVK 164
G L I + A + LE GA + +T +G P+ + A +
Sbjct: 501 HPDAATTNGYTPLH--ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA---KYGSL 555
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
DV L++ A ++ + G T L A+ ++ +LE+G +A + + H
Sbjct: 556 DVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 614
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
AAK I L Y + +++ G TPLH A+ G D + +G ++
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/121 (30%), Positives = 61/121 (50%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
+++ K G + +++ G VD T L A +G +VVK L+++GAN+NA
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPL+ A D+V+ L+E+GA A+ + TPL A++ V LL+
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 166
Query: 616 K 616
K
Sbjct: 167 K 167
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/131 (29%), Positives = 64/131 (48%), Gaps = 4/131 (3%)
Query: 551 VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610
VN T +TPLH A H G ++ LL+ GA +D + N TPL+ A + + VK L
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 611 LDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTE 670
LD G + + R G + + A ++++L+ E+ L +N G +P + +
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN----GLSPLHMAAQ 320
Query: 671 GPEIKKEEELL 681
G ++ + LL
Sbjct: 321 GDHVECVKHLL 331
Score = 57.0 bits (136), Expect = 7e-08
Identities = 71/280 (25%), Positives = 116/280 (41%), Gaps = 11/280 (3%)
Query: 17 LQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDV 76
+ C +N+ K +E L K G + TE +GL+ +H+A+ +++V LL GA PDV
Sbjct: 383 IACKKNRIKV-MELLVKYG-ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438
Query: 77 QDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIAL 136
+ G T AA G + L + A + E + L K + L
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI--VQLLL 496
Query: 137 EHGADVNNSTYEG-KPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
+H A + +T G P+ + A E DV V LE GA +++ + G T L A++
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASV---LLEAGA-AHSLATKKGFTPLHVAAKY 552
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G +++ + +L+R ++ + H AA + LL + NG TPL
Sbjct: 553 GSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPL 612
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
H AA + G + TP +A + G
Sbjct: 613 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 652
Score = 50.8 bits (120), Expect = 5e-06
Identities = 29/114 (25%), Positives = 57/114 (50%)
Query: 180 INSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFA 239
+ S + + A+R G ++ V L+ G ++N + + +A H AAK G +++ L
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 240 YNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKE 293
V + GNT LH A++ G A+ K + + G ++ ++ + TP +A +
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 118
Score = 48.9 bits (115), Expect = 2e-05
Identities = 42/188 (22%), Positives = 73/188 (38%), Gaps = 37/188 (19%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++I + AG +K + G ++ + TPL A +IDVVK+LLE GAN +
Sbjct: 80 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 139
Query: 556 NFLWTPLHFACHAGQQDIVELLVE------------------------------------ 579
+TPL A G V +L+E
Sbjct: 140 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 199
Query: 580 -SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYR 638
S +++ + + TPL+ A ++ LL+ GA R G + + VA +
Sbjct: 200 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 259
Query: 639 IIDLIKEK 646
++ L+ ++
Sbjct: 260 MVKLLLDR 267
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 131 bits (329), Expect = 3e-30
Identities = 155/624 (24%), Positives = 261/624 (41%), Gaps = 65/624 (10%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG + L++A+ N ID+V +LL+ GA+ G TP A + GH ++ IL
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL------ 182
Query: 107 MTIVDNEGKGVL---FYCILPTKRHYRCALIALE--HGADV------NNSTYEG-KPIFL 154
++N+ KG + I K + A + L+ H ADV N +T G P+ +
Sbjct: 183 ---LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 155 RACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAF 214
A + +V L +GA + + G T L AS+ G +V+ +L+RGG+++A
Sbjct: 240 AA---HYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
Query: 215 DNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
D H AA+ G +++LL + + NG +PLH AA G +C K++ Q
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Query: 275 CDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPN---PLW------ 325
+ LD+ T VA G R + + +K A P A+ N PL
Sbjct: 356 APVDDVTLDYLTALHVAAHCG------HYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
Query: 326 ALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV----MVLEERQDYASSE--QLAAIA 379
+++ + V+ A ++ A+ + G I F+ +VL Q+ AS + +
Sbjct: 410 RIKVMELLVKYGASIQ---AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Query: 380 HLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIP 439
LH R G V + R L ++ L ++++ + + GK + +
Sbjct: 467 ALHMAARAGQVEV------VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 440 EYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINII 499
+ +G P + I + D + + H + ++K F+ +++
Sbjct: 521 AHPDAATTNGYTPLH-ISAREGQVDVASVLLEAGAAHSLA---------TKKGFTPLHVA 570
Query: 500 TKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLW 559
K G L K + D TPL A N V LLEKGA+ +AT +
Sbjct: 571 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQL 619
TPLH A Q I L+ GA + + TPL+ A + D V LLD GA +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690
Query: 620 ENRKGHSAMDVAKAYADYRIIDLI 643
+ G +++ +A + D++
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADIL 714
Score = 111 bits (278), Expect = 2e-24
Identities = 144/658 (21%), Positives = 239/658 (36%), Gaps = 99/658 (15%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG++ LH+AS + +MV LLD G D + R G TP AA GH+ +E+L + A
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ G L + H C L+H A V+ DV
Sbjct: 325 LLARTKNGLSPLH--MAAQGDHVECVKHLLQHKAPVD---------------------DV 361
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L +L TAL A+ G + + +L++ NA + H A
Sbjct: 362 TLDYL---------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 406
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
K +++LL Y + I+ +G TP+H AA G + + Q G N+ +T
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Query: 287 PRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAV 346
+A G + + R + + AR E + L A
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAR-------------------EEQTPLHIA--- 504
Query: 347 LDRGDGSISKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSF 406
+ K + V +L + + + LH R G V++ L ++
Sbjct: 505 -----SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV------ASVLLEAG 553
Query: 407 VLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKN----- 461
S KK + K G + + A ++G P ++ Y N
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613
Query: 462 ------VTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVF-SNINIITKAG----------- 503
+ + + P H + I + + + NI+TK G
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673
Query: 504 --DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
D+ +L + G + M T L A ++V L + GA+ +A +TP
Sbjct: 674 HTDMVTL--LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L ACH G +V L++ GA ++A + N TPL++A + + LL GAK
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791
Query: 622 RKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGK-TPPILKTEGPEIKKEE 678
G++A+ +AK ++D +K + + K K P TE ++ EE
Sbjct: 792 ANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEE 849
Score = 76.6 bits (187), Expect = 8e-14
Identities = 58/193 (30%), Positives = 90/193 (46%), Gaps = 4/193 (2%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+E F+ ++I G++ G VD TPL A GN ++VK LL++G
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
++A TPLH A +G +VELL+E GA + A + N +PL+ A + ++ VK
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILK 668
+LL A +A+ VA YR+ L+ +K N + L G TP +
Sbjct: 350 HLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN----PNARALNGFTPLHIA 405
Query: 669 TEGPEIKKEEELL 681
+ IK E L+
Sbjct: 406 CKKNRIKVMELLV 418
Score = 75.1 bits (183), Expect = 2e-13
Identities = 61/223 (27%), Positives = 104/223 (46%), Gaps = 10/223 (4%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
+++ +AG + ++ +G VD + +TPL A G ++V+ LL+ A+ +A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPLH + GQ D+ +L+E+GA A+ TPL+ A + LD K LL A
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 616 KFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
+ G + + VA Y + ++ L+ EK + A+N G TP + + +++
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN----GYTPLHIAAKKNQMQ 643
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDI 718
LL+ YG T V K V L+ G+T V +
Sbjct: 644 IASTLLN--YGAETNI----VTKQGVTPLHLASQEGHTDMVTL 680
Score = 72.4 bits (176), Expect = 2e-12
Identities = 45/145 (31%), Positives = 77/145 (53%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
+AG+L + + + GI ++ + L A G++ +V+ LL +G++V++ T
Sbjct: 40 RAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNT 99
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
LH A AGQ ++V++LV+ GA I+A S N TPL A + +D VKYLL+ GA
Sbjct: 100 ALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTA 159
Query: 621 NRKGHSAMDVAKAYADYRIIDLIKE 645
G + + VA + + ++ E
Sbjct: 160 TEDGFTPLAVALQQGHNQAVAILLE 184
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/283 (24%), Positives = 115/283 (40%), Gaps = 38/283 (13%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NGL+ALHLA+ + +V LL G+ D + G T A+ G +++L K A+
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAH----- 161
+ G L+ + + H LE+GA+ + +T +G A + H
Sbjct: 123 INAQSQNGFTPLY--MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 162 -----------------------DVKDVCLTFLEKGANPNA-----INSST--GRTALME 191
D K L L+ N + +N +T G T L
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAAL-LLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 192 ASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISING 251
A+ G V + +L RG V+ + H A+K G +++KLL G + + +G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 252 NTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEG 294
TPLH AA G + + +RG L + + +P +A +G
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
Score = 67.4 bits (163), Expect = 5e-11
Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 3/147 (2%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
FLRA + D + +L+ G + N N + G AL A++EG V +V+ +L RG V+
Sbjct: 35 FLRAARAGN--LDKVVEYLKGGIDINTCNQN-GLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ + A H A+ G +++K+L ++ S NG TPL+ AA D KY+ +
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 273 RGCDLKWKNLDHKTPRAVAKEGGFKAA 299
G + D TP AVA + G A
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQA 178
Score = 66.2 bits (160), Expect = 1e-10
Identities = 71/276 (25%), Positives = 114/276 (41%), Gaps = 19/276 (6%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKA 105
+NG + LH+A N I ++ L+ GA G TP AA +GH + +L + A
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 106 DMTIVDNEGKGVLFYCILPTKRHY-RCALIALEHGADVN-NSTYEGKPIFLRACEDAHDV 163
+ + G+ L + RC L +GA V+ + E P+ + + ++
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 164 KDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAH 223
+ L + A+P+A ++ G T L ++REG V++ +LE G + H
Sbjct: 513 VQLLLQHM---AHPDAATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568
Query: 224 FAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLD 283
AAK G D+ KLL NG TPLH AA + ++G
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA-------- 620
Query: 284 HKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAK 319
+P A AK G + +IA+ L GA+
Sbjct: 621 --SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Score = 65.5 bits (158), Expect = 2e-10
Identities = 60/233 (25%), Positives = 103/233 (44%), Gaps = 7/233 (3%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKA 105
I G +ALH+A+ + +++V LL GA D + R TP A+ LG +++L + A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521
Query: 106 DMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEG-KPIFLRACEDAHDVK 164
G L I + A + LE GA + +T +G P+ + A +
Sbjct: 522 HPDAATTNGYTPLH--ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA---KYGSL 576
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
DV L++ A ++ + G T L A+ ++ +LE+G +A + + H
Sbjct: 577 DVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 635
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
AAK I L Y + +++ G TPLH A+ G D + +G ++
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/121 (30%), Positives = 61/121 (50%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
+++ K G + +++ G VD T L A +G +VVK L+++GAN+NA
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPL+ A D+V+ L+E+GA A+ + TPL A++ V LL+
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
Query: 616 K 616
K
Sbjct: 188 K 188
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/131 (29%), Positives = 64/131 (48%), Gaps = 4/131 (3%)
Query: 551 VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610
VN T +TPLH A H G ++ LL+ GA +D + N TPL+ A + + VK L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 611 LDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTE 670
LD G + + R G + + A ++++L+ E+ L +N G +P + +
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN----GLSPLHMAAQ 341
Query: 671 GPEIKKEEELL 681
G ++ + LL
Sbjct: 342 GDHVECVKHLL 352
Score = 57.0 bits (136), Expect = 7e-08
Identities = 71/280 (25%), Positives = 116/280 (41%), Gaps = 11/280 (3%)
Query: 17 LQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDV 76
+ C +N+ K +E L K G + TE +GL+ +H+A+ +++V LL GA PDV
Sbjct: 404 IACKKNRIKV-MELLVKYG-ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 77 QDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIAL 136
+ G T AA G + L + A + E + L K + L
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI--VQLLL 517
Query: 137 EHGADVNNSTYEG-KPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
+H A + +T G P+ + A E DV V LE GA +++ + G T L A++
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASV---LLEAGA-AHSLATKKGFTPLHVAAKY 573
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G +++ + +L+R ++ + H AA + LL + NG TPL
Sbjct: 574 GSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPL 633
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
H AA + G + TP +A + G
Sbjct: 634 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673
Score = 50.8 bits (120), Expect = 5e-06
Identities = 34/136 (25%), Positives = 61/136 (44%)
Query: 158 EDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
EDA D F S + + A+R G ++ V L+ G ++N + +
Sbjct: 4 EDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQN 63
Query: 218 RHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
+A H AAK G +++ L V + GNT LH A++ G A+ K + + G ++
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 278 KWKNLDHKTPRAVAKE 293
++ + TP +A +
Sbjct: 124 NAQSQNGFTPLYMAAQ 139
Score = 48.9 bits (115), Expect = 2e-05
Identities = 42/188 (22%), Positives = 73/188 (38%), Gaps = 37/188 (19%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++I + AG +K + G ++ + TPL A +IDVVK+LLE GAN +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 556 NFLWTPLHFACHAGQQDIVELLVE------------------------------------ 579
+TPL A G V +L+E
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 220
Query: 580 -SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYR 638
S +++ + + TPL+ A ++ LL+ GA R G + + VA +
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 639 IIDLIKEK 646
++ L+ ++
Sbjct: 281 MVKLLLDR 288
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 131 bits (329), Expect = 3e-30
Identities = 155/624 (24%), Positives = 261/624 (41%), Gaps = 65/624 (10%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG + L++A+ N ID+V +LL+ GA+ G TP A + GH ++ IL
Sbjct: 129 NGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL------ 182
Query: 107 MTIVDNEGKGVL---FYCILPTKRHYRCALIALE--HGADV------NNSTYEG-KPIFL 154
++N+ KG + I K + A + L+ H ADV N +T G P+ +
Sbjct: 183 ---LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 155 RACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAF 214
A + +V L +GA + + G T L AS+ G +V+ +L+RGG+++A
Sbjct: 240 AA---HYGNVNVATLLLNRGAAVD-FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
Query: 215 DNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
D H AA+ G +++LL + + NG +PLH AA G +C K++ Q
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Query: 275 CDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPN---PLW------ 325
+ LD+ T VA G R + + +K A P A+ N PL
Sbjct: 356 APVDDVTLDYLTALHVAAHCG------HYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
Query: 326 ALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFV----MVLEERQDYASSE--QLAAIA 379
+++ + V+ A ++ A+ + G I F+ +VL Q+ AS + +
Sbjct: 410 RIKVMELLVKYGASIQ---AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Query: 380 HLHEKTRGGGVNINEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIP 439
LH R G V + R L ++ L ++++ + + GK + +
Sbjct: 467 ALHMAARAGQVEV------VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 440 EYAFPRRQDGGPPYYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINII 499
+ +G P + I + D + + H + ++K F+ +++
Sbjct: 521 AHPDAATTNGYTPLH-ISAREGQVDVASVLLEAGAAHSLA---------TKKGFTPLHVA 570
Query: 500 TKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLW 559
K G L K + D TPL A N V LLEKGA+ +AT +
Sbjct: 571 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQL 619
TPLH A Q I L+ GA + + TPL+ A + D V LLD GA +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690
Query: 620 ENRKGHSAMDVAKAYADYRIIDLI 643
+ G +++ +A + D++
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADIL 714
Score = 111 bits (278), Expect = 2e-24
Identities = 144/658 (21%), Positives = 239/658 (36%), Gaps = 99/658 (15%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG++ LH+AS + +MV LLD G D + R G TP AA GH+ +E+L + A
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ G L + H C L+H A V+ DV
Sbjct: 325 LLARTKNGLSPLH--MAAQGDHVECVKHLLQHKAPVD---------------------DV 361
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L +L TAL A+ G + + +L++ NA + H A
Sbjct: 362 TLDYL---------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 406
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
K +++LL Y + I+ +G TP+H AA G + + Q G N+ +T
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Query: 287 PRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAV 346
+A G + + R + + AR E + L A
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAR-------------------EEQTPLHIA--- 504
Query: 347 LDRGDGSISKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNINEFFKGTRYLNKSF 406
+ K + V +L + + + LH R G V++ L ++
Sbjct: 505 -----SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV------ASVLLEAG 553
Query: 407 VLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKN----- 461
S KK + K G + + A ++G P ++ Y N
Sbjct: 554 AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVAL 613
Query: 462 ------VTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVF-SNINIITKAG----------- 503
+ + + P H + I + + + NI+TK G
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673
Query: 504 --DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
D+ +L + G + M T L A ++V L + GA+ +A +TP
Sbjct: 674 HTDMVTL--LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L ACH G +V L++ GA ++A + N TPL++A + + LL GAK
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791
Query: 622 RKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGK-TPPILKTEGPEIKKEE 678
G++A+ +AK ++D +K + + K K P TE ++ EE
Sbjct: 792 ANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEE 849
Score = 76.6 bits (187), Expect = 8e-14
Identities = 58/193 (30%), Positives = 90/193 (46%), Gaps = 4/193 (2%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+E F+ ++I G++ G VD TPL A GN ++VK LL++G
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
++A TPLH A +G +VELL+E GA + A + N +PL+ A + ++ VK
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILK 668
+LL A +A+ VA YR+ L+ +K N + L G TP +
Sbjct: 350 HLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN----PNARALNGFTPLHIA 405
Query: 669 TEGPEIKKEEELL 681
+ IK E L+
Sbjct: 406 CKKNRIKVMELLV 418
Score = 75.1 bits (183), Expect = 2e-13
Identities = 61/223 (27%), Positives = 104/223 (46%), Gaps = 10/223 (4%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
+++ +AG + ++ +G VD + +TPL A G ++V+ LL+ A+ +A
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPLH + GQ D+ +L+E+GA A+ TPL+ A + LD K LL A
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 616 KFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
+ G + + VA Y + ++ L+ EK + A+N G TP + + +++
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN----GYTPLHIAAKKNQMQ 643
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDI 718
LL+ YG T V K V L+ G+T V +
Sbjct: 644 IASTLLN--YGAETNI----VTKQGVTPLHLASQEGHTDMVTL 680
Score = 72.4 bits (176), Expect = 2e-12
Identities = 45/145 (31%), Positives = 77/145 (53%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
+AG+L + + + GI ++ + L A G++ +V+ LL +G++V++ T
Sbjct: 40 RAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNT 99
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
LH A AGQ ++V++LV+ GA I+A S N TPL A + +D VKYLL+ GA
Sbjct: 100 ALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTA 159
Query: 621 NRKGHSAMDVAKAYADYRIIDLIKE 645
G + + VA + + ++ E
Sbjct: 160 TEDGFTPLAVALQQGHNQAVAILLE 184
Score = 68.6 bits (166), Expect = 2e-11
Identities = 70/283 (24%), Positives = 115/283 (40%), Gaps = 38/283 (13%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NGL+ALHLA+ + +V LL G+ D + G T A+ G +++L K A+
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAH----- 161
+ G L+ + + H LE+GA+ + +T +G A + H
Sbjct: 123 INAQSQNGFTPLY--MAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 162 -----------------------DVKDVCLTFLEKGANPNA-----INSST--GRTALME 191
D K L L+ N + +N +T G T L
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAAL-LLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 192 ASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISING 251
A+ G V + +L RG V+ + H A+K G +++KLL G + + +G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 252 NTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEG 294
TPLH AA G + + +RG L + + +P +A +G
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
Score = 67.4 bits (163), Expect = 5e-11
Identities = 47/147 (31%), Positives = 73/147 (49%), Gaps = 3/147 (2%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
FLRA + D + +L+ G + N N + G AL A++EG V +V+ +L RG V+
Sbjct: 35 FLRAARAGN--LDKVVEYLKGGIDINTCNQN-GLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ + A H A+ G +++K+L ++ S NG TPL+ AA D KY+ +
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 273 RGCDLKWKNLDHKTPRAVAKEGGFKAA 299
G + D TP AVA + G A
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQA 178
Score = 66.2 bits (160), Expect = 1e-10
Identities = 71/276 (25%), Positives = 114/276 (41%), Gaps = 19/276 (6%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKA 105
+NG + LH+A N I ++ L+ GA G TP AA +GH + +L + A
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 106 DMTIVDNEGKGVLFYCILPTKRHY-RCALIALEHGADVN-NSTYEGKPIFLRACEDAHDV 163
+ + G+ L + RC L +GA V+ + E P+ + + ++
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEI 512
Query: 164 KDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAH 223
+ L + A+P+A ++ G T L ++REG V++ +LE G + H
Sbjct: 513 VQLLLQHM---AHPDAATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568
Query: 224 FAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLD 283
AAK G D+ KLL NG TPLH AA + ++G
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA-------- 620
Query: 284 HKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAK 319
+P A AK G + +IA+ L GA+
Sbjct: 621 --SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Score = 65.5 bits (158), Expect = 2e-10
Identities = 60/233 (25%), Positives = 103/233 (44%), Gaps = 7/233 (3%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKA 105
I G +ALH+A+ + +++V LL GA D + R TP A+ LG +++L + A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521
Query: 106 DMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEG-KPIFLRACEDAHDVK 164
G L I + A + LE GA + +T +G P+ + A +
Sbjct: 522 HPDAATTNGYTPLH--ISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAA---KYGSL 576
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
DV L++ A ++ + G T L A+ ++ +LE+G +A + + H
Sbjct: 577 DVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHI 635
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
AAK I L Y + +++ G TPLH A+ G D + +G ++
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/121 (30%), Positives = 61/121 (50%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
+++ K G + +++ G VD T L A +G +VVK L+++GAN+NA
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPL+ A D+V+ L+E+GA A+ + TPL A++ V LL+
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDT 187
Query: 616 K 616
K
Sbjct: 188 K 188
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/131 (29%), Positives = 64/131 (48%), Gaps = 4/131 (3%)
Query: 551 VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610
VN T +TPLH A H G ++ LL+ GA +D + N TPL+ A + + VK L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 611 LDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTE 670
LD G + + R G + + A ++++L+ E+ L +N G +P + +
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN----GLSPLHMAAQ 341
Query: 671 GPEIKKEEELL 681
G ++ + LL
Sbjct: 342 GDHVECVKHLL 352
Score = 57.0 bits (136), Expect = 7e-08
Identities = 71/280 (25%), Positives = 116/280 (41%), Gaps = 11/280 (3%)
Query: 17 LQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDV 76
+ C +N+ K +E L K G + TE +GL+ +H+A+ +++V LL GA PDV
Sbjct: 404 IACKKNRIKV-MELLVKYG-ASIQAITE--SGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459
Query: 77 QDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIAL 136
+ G T AA G + L + A + E + L K + L
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEI--VQLLL 517
Query: 137 EHGADVNNSTYEG-KPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
+H A + +T G P+ + A E DV V LE GA +++ + G T L A++
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASV---LLEAGA-AHSLATKKGFTPLHVAAKY 573
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G +++ + +L+R ++ + H AA + LL + NG TPL
Sbjct: 574 GSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPL 633
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
H AA + G + TP +A + G
Sbjct: 634 HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEG 673
Score = 50.8 bits (120), Expect = 5e-06
Identities = 34/136 (25%), Positives = 61/136 (44%)
Query: 158 EDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
EDA D F S + + A+R G ++ V L+ G ++N + +
Sbjct: 4 EDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQN 63
Query: 218 RHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
+A H AAK G +++ L V + GNT LH A++ G A+ K + + G ++
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 278 KWKNLDHKTPRAVAKE 293
++ + TP +A +
Sbjct: 124 NAQSQNGFTPLYMAAQ 139
Score = 48.9 bits (115), Expect = 2e-05
Identities = 42/188 (22%), Positives = 73/188 (38%), Gaps = 37/188 (19%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++I + AG +K + G ++ + TPL A +IDVVK+LLE GAN +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT 160
Query: 556 NFLWTPLHFACHAGQQDIVELLVE------------------------------------ 579
+TPL A G V +L+E
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 220
Query: 580 -SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYR 638
S +++ + + TPL+ A ++ LL+ GA R G + + VA +
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 639 IIDLIKEK 646
++ L+ ++
Sbjct: 281 MVKLLLDR 288
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 112 bits (279), Expect = 2e-24
Identities = 116/479 (24%), Positives = 198/479 (41%), Gaps = 50/479 (10%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
+LRA H K L +++ G + N N + G AL AS+EG VE+V +L+R V+
Sbjct: 45 YLRAARAGHLEK--ALDYIKNGVDINICNQN-GLNALHLASKEGHVEVVSELLQREANVD 101
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
A + A H A+ G +++K+L +V S NG TPL+ AA + K++
Sbjct: 102 AATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
Query: 273 RGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLHDW 332
G D TP AVA + G +++ + L K L AL +
Sbjct: 162 NGASQSLATEDGFTPLAVALQQGH----------DQVVSLLLENDTKGKVRLPALHIAAR 211
Query: 333 SVEREAFLREAFAVLDRGDGSISKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNI 392
+ +A +L + + A E + LH G +N+
Sbjct: 212 KDDTKA---------------------AALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250
Query: 393 NEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGPP 452
T LN++ + + + + K+G + + + +DG P
Sbjct: 251 -----ATLLLNRAAAV-DFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304
Query: 453 YYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINIITKAGDLASLKKAF 512
+ +R + E + D + + ++ S +++ T+ L ++
Sbjct: 305 LHC---------GARSGHEQVVE-MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ +PVD N Y T L A G+ V K LL+K AN NA +TPLH AC +
Sbjct: 355 QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIK 414
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
++ELL++ GA I A + + TP++ A ++ V L+ GA N +G +A+ +A
Sbjct: 415 VMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Score = 108 bits (270), Expect = 2e-23
Identities = 140/600 (23%), Positives = 230/600 (38%), Gaps = 49/600 (8%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG + L++A+ N +++V FLLD GA + G TP A + GH+ + +L
Sbjct: 139 NGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL------ 192
Query: 107 MTIVDNEGKGVL---FYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDV 163
++N+ KG + I K + A + L++ NN+ E K F AH
Sbjct: 193 ---LENDTKGKVRLPALHIAARKDDTKAAALLLQND---NNADVESKSGFTPLHIAAHYG 246
Query: 164 KDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAH 223
T L A + T L AS+ G +V+ +L+RG +++A D H
Sbjct: 247 NINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLH 306
Query: 224 FAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLD 283
A+ G ++++L + + NG +PLH A G +C + + Q + D
Sbjct: 307 CGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTND 366
Query: 284 HKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPN---PLWALRLHDWSVEREAFL 340
+ T VA G + A+ + +K A P AK N PL + E L
Sbjct: 367 YLTALHVAAHCG------HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL 420
Query: 341 REAF---AVLDRGDGSISKNDF---VMVLEERQDYASSEQLAAI---AHLHEKTRGGGVN 391
+ AV + G I F V ++ + + +S + LH R G
Sbjct: 421 KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 392 INEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGP 451
+ RYL + K + + + GK + + G
Sbjct: 481 V------VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYT 534
Query: 452 PYYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINIITKAGDLASLKKA 511
P + + + D + F DH I ++K F+ +++ K G L
Sbjct: 535 PLH-LSAREGHEDVAAFLLDHGASLSI---------TTKKGFTPLHVAAKYGKLEVANLL 584
Query: 512 FESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQ 571
+ D TPL A N V LL++GA+ +A +TPLH A Q
Sbjct: 585 LQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644
Query: 572 DIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
DI L+E GA +A + ++ A + +D V LL A L N+ G + + +A
Sbjct: 645 DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704
Score = 100 bits (250), Expect = 4e-21
Identities = 156/699 (22%), Positives = 275/699 (39%), Gaps = 69/699 (9%)
Query: 49 LSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGH-ELSMEILAKAKADM 107
L ALH+A+ +D + LL + DV+ + G TP AA G+ ++ +L +A A
Sbjct: 203 LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAA-- 260
Query: 108 TIVDNEGKGVLFYCILPTKR-HYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
VD + + + +KR + + L+ GA ++ T +G H+ V
Sbjct: 261 --VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHE--QV 316
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L++ A P + G + L A++ + V+ +L+ V+ ND A H AA
Sbjct: 317 VEMLLDRAA-PILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAA 375
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G + + K+L + ++NG TPLH A + + + G ++ T
Sbjct: 376 HCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLT 435
Query: 287 PRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLR----- 341
P VA G + ++ + A P N AL + S + E
Sbjct: 436 PIHVAAFMG------HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG 489
Query: 342 ---EAFAVLDRGDGSIS----KNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGVNINE 394
EA A D+ IS K D V L ++ ++ + LH R G ++
Sbjct: 490 AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAA 549
Query: 395 FFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRR--QDGGPP 452
F L+ L S KK + K GK L + ++ + A P + G P
Sbjct: 550 FL-----LDHGASL-SITTKKGFTPLHVAAKYGK--LEVANLLLQKSASPDAAGKSGLTP 601
Query: 453 YYMIETYKN-----------VTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVF-SNINIIT 500
++ Y N + + + P H + I + + ++ N +T
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 501 KAGDLASLKKAFESG------------IPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+ G +AS+ A + G V++ + TPL A ++V + L+ +G
Sbjct: 662 RQG-IASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A+V+A +TPLH CH G IV L++ A ++A + N TPL++A + +
Sbjct: 721 AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN 780
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIK-EKLDNLPKPAENQKLKGKTP--- 664
LL A G++A+ +A+ ++D +K + + +K K P
Sbjct: 781 VLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETM 840
Query: 665 -PILKTEGPEIKKEE--ELLSSIYGVPTTSEGKKVQKGN 700
+L E++K E+LS + EG+ G+
Sbjct: 841 NEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGD 879
Score = 85.5 bits (210), Expect = 2e-16
Identities = 85/314 (27%), Positives = 128/314 (40%), Gaps = 15/314 (4%)
Query: 17 LQC-VRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPD 75
L C R+ ++ +E L P L ++ NGLS LH+A+ + ++ V LL D
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPIL---SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Query: 76 VQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIA 135
T AA GH ++L KA+ G L I K + +
Sbjct: 362 DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH--IACKKNRIKVMELL 419
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
L+HGA + T G A H ++ + GA+PN N G TAL A+R
Sbjct: 420 LKHGASIQAVTESGLTPIHVAAFMGH--VNIVSQLMHHGASPNTTNVR-GETALHMAARS 476
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G E+VR +++ G +V A D H +A+ G DI++ L + +G TPL
Sbjct: 477 GQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPL 536
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLAR 315
H +A G D ++ G L TP VA + G ++ A + K A
Sbjct: 537 HLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG------KLEVANLLLQKSAS 590
Query: 316 PGAKNPNPLWALRL 329
P A + L L +
Sbjct: 591 PDAAGKSGLTPLHV 604
Score = 82.0 bits (201), Expect = 2e-15
Identities = 74/285 (25%), Positives = 113/285 (39%), Gaps = 38/285 (13%)
Query: 44 EPINGLSALHLA---------------------SVSNDI------------DMVSFLLDL 70
E +G + LH+A + NDI +MV LLD
Sbjct: 231 ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR 290
Query: 71 GAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYR 130
GA D + R G TP A GHE +E+L A + G L + H
Sbjct: 291 GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH--MATQGDHLN 348
Query: 131 CALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALM 190
C + L+H V++ T + A H V L+K ANPNA + G T L
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGH--YKVAKVLLDKKANPNA-KALNGFTPLH 405
Query: 191 EASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISIN 250
A ++ ++++ +L+ G + A H AA G +I+ L + ++
Sbjct: 406 IACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465
Query: 251 GNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
G T LH AA G A+ +Y+ Q G ++ K D +TP ++ G
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 510
Score = 78.6 bits (192), Expect = 2e-14
Identities = 48/145 (33%), Positives = 78/145 (53%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
+AG L ++G+ +++ + L A G+++VV LL++ ANV+A T
Sbjct: 50 RAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNT 109
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
LH A AGQ ++V++LV +GA ++A S N TPL A + L+ VK+LLD GA L
Sbjct: 110 ALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA 169
Query: 621 NRKGHSAMDVAKAYADYRIIDLIKE 645
G + + VA +++ L+ E
Sbjct: 170 TEDGFTPLAVALQQGHDQVVSLLLE 194
Score = 76.6 bits (187), Expect = 8e-14
Identities = 65/249 (26%), Positives = 100/249 (40%), Gaps = 5/249 (2%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
G + LH+A+ +++ + LL A PD + G TP AA ++ +L A
Sbjct: 565 GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Query: 108 TIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVC 167
G L I K A LE+GAD N T +G A ++ H D+
Sbjct: 625 HAAAKNGYTPLH--IAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH--VDMV 680
Query: 168 LTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAK 227
L + AN N N S G T L A++E V + ++ +G V+A + H
Sbjct: 681 SLLLGRNANVNLSNKS-GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCH 739
Query: 228 GGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTP 287
G I+ L ++ V + NG TPLH AA G + Q ++ T
Sbjct: 740 YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTA 799
Query: 288 RAVAKEGGF 296
+A+ G+
Sbjct: 800 LGIARRLGY 808
Score = 71.6 bits (174), Expect = 3e-12
Identities = 62/218 (28%), Positives = 100/218 (45%), Gaps = 7/218 (3%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+GL+ LH+A+ ++ + LLD GA P + G TP AA+ L + AD
Sbjct: 597 SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEG-KPIFLRACEDAHDVKD 165
V + G+ + + H + L A+VN S G P+ L A ED +V +
Sbjct: 657 ANAVTRQ--GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAE 714
Query: 166 VCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFA 225
V + +GA+ +A + G T L G ++IV +L+ +VNA + + H A
Sbjct: 715 V---LVNQGAHVDA-QTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 770
Query: 226 AKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGF 263
A+ G I+ +L N +++NGNT L A G+
Sbjct: 771 AQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGY 808
Score = 68.9 bits (167), Expect = 2e-11
Identities = 69/267 (25%), Positives = 107/267 (40%), Gaps = 10/267 (3%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NGL+ALHLAS +++VS LL A+ D + G T A+ G +++L A+
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ G L+ + + H L++GA + +T +G A + HD V
Sbjct: 133 VNAQSQNGFTPLY--MAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHD--QV 188
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
LE N AL A+R+ + +L+ + H AA
Sbjct: 189 VSLLLE-----NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAA 243
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G ++ LL V + N TPLH A+ G A+ K + RG + K D T
Sbjct: 244 HYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLT 303
Query: 287 P-RAVAKEGGFKAASKEIRRAERIANK 312
P A+ G + + RA I +K
Sbjct: 304 PLHCGARSGHEQVVEMLLDRAAPILSK 330
Score = 58.9 bits (141), Expect = 2e-08
Identities = 40/163 (24%), Positives = 71/163 (43%), Gaps = 4/163 (2%)
Query: 519 DMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLV 578
D K L A + LL+ N + +TPLH A H G ++ LL+
Sbjct: 196 DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL 255
Query: 579 ESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYR 638
A +D + N+ TPL+ A + + VK LLD GAK + R G + + +
Sbjct: 256 NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQ 315
Query: 639 IIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEELL 681
+++++ ++ P ++ G +P + T+G + + LL
Sbjct: 316 VVEMLLDR----AAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
Score = 57.8 bits (138), Expect = 4e-08
Identities = 70/271 (25%), Positives = 112/271 (41%), Gaps = 31/271 (11%)
Query: 17 LQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDV 76
+ C +N+ K +E L K G + TE +GL+ +H+A+ +++VS L+ GA P+
Sbjct: 406 IACKKNRIKV-MELLLKHG-ASIQAVTE--SGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 77 QDRMGCTPTMRAAELGH--------ELSMEILAKAKADMT---IVDNEGKGVLFYCILPT 125
+ G T AA G + ++ AKAK D T I GK + +L
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL-- 519
Query: 126 KRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTG 185
+ GA N +T G + + H+ DV L+ GA+ + I + G
Sbjct: 520 -----------QQGASPNAATTSGYTPLHLSAREGHE--DVAAFLLDHGASLS-ITTKKG 565
Query: 186 RTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVG 245
T L A++ G +E+ +L++ +A H AA + LL
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH 625
Query: 246 LISINGNTPLHYAAMGGFADCCKYIAQRGCD 276
+ NG TPLH AA D + + G D
Sbjct: 626 AAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/120 (24%), Positives = 61/120 (50%), Gaps = 3/120 (2%)
Query: 530 MTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASI 589
+ A +G+++ ++ G ++N + LH A G ++V L++ A +DAA+
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
Query: 590 NNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDN 649
+T L+ A + + + VK L+ GA +++ G + + +A A ++++K LDN
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA---AQENHLEVVKFLLDN 162
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 97.8 bits (242), Expect = 3e-20
Identities = 134/607 (22%), Positives = 230/607 (37%), Gaps = 61/607 (10%)
Query: 51 ALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIV 110
ALH A+ +D+V+ L++ GA +D+ G TP AA G ++ L ++ +
Sbjct: 151 ALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEI 210
Query: 111 DNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTF 170
+ G L + LI ++GA+VN G A H +CL
Sbjct: 211 NVYGNTALHIACYNGQDAVVNELI--DYGANVNQPNNNGFTPLHFAAASTHGA--LCLEL 266
Query: 171 L-EKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGG 229
L GA+ N I S G++ L + G + +++ GGE++ D D + H AA+ G
Sbjct: 267 LVNNGADVN-IQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYG 325
Query: 230 FFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRA 289
++ L D I+ PLH AA+ +DCC+ + G ++ + +T
Sbjct: 326 HELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLH 385
Query: 290 VAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRLH------------------D 331
A GG K ++ + +K + G + P A H D
Sbjct: 386 AAAAGGNVECIKLLQSSGADFHKKDKCG-RTPLHYAAANCHFHCIETLVTTGANVNETDD 444
Query: 332 WSVEREAFLREAFAVLDRGDGSI-SKNDFVMVLEERQDYASSEQLAAIAHLHEKTRGGGV 390
W R A A + +DR + + +D LE ++ E + L + +
Sbjct: 445 WG--RTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSI 502
Query: 391 NINEFFKGTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGG 450
E + Y +YG ++ + + ++ G F G
Sbjct: 503 RDKEGYNSIHY------AAAYGHRQCLELLLERTNSG---------------FEESDSGA 541
Query: 451 PPYYMIETYKNVTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINIITKAGDLASLKK 510
K+ + +N H + V EK + +++ G ++
Sbjct: 542 T--------KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEA 593
Query: 511 AFESGIPVDMKDNYYK-TPLMTACASGNIDVVKFLLEKGAN---VNATDNFLWTPLHFAC 566
G + +KDN K TPL + +G+ ++ LLE N V+ D TPL A
Sbjct: 594 LINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAV 653
Query: 567 HAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHS 626
G D V LL+E A +D I T L+R I + + V+ LL+ ++ +G +
Sbjct: 654 AYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRT 713
Query: 627 AMDVAKA 633
+ A A
Sbjct: 714 PLHYAAA 720
Score = 92.4 bits (228), Expect = 1e-18
Identities = 141/656 (21%), Positives = 255/656 (38%), Gaps = 55/656 (8%)
Query: 9 ENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLL 68
+N+ + + + V ++ ++ ++ L K + +N + N + LH+A+ + + ++
Sbjct: 46 DNMWLTPLHRAVASRSEEAVQVLIK--HSADVNARDK-NWQTPLHVAAANKAVKCAEVII 102
Query: 69 DLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRH 128
L + +V DR G T AA GH + +L A++ D + + L + H
Sbjct: 103 PLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY--MGH 160
Query: 129 YRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTA 188
+ + HGA+V +G A + +V L G + IN G TA
Sbjct: 161 LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQI--NVVKHLLNLGVEIDEINVY-GNTA 217
Query: 189 LMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNG-DVGLI 247
L A G +V +++ G VN +N+ HFAA + L NG DV +
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277
Query: 248 SINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAE 307
S +G +PLH A+ G + + Q G ++ + D TP VA G + +R +
Sbjct: 278 SKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTS- 336
Query: 308 RIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAV----------LDRGDGSISKN 357
A+ G + PL L+ S L F + L +
Sbjct: 337 --GADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE 394
Query: 358 DFVMVLEERQDYASSEQ--------LAAIAHLH--EKTRGGGVNINE----------FFK 397
++ D+ ++ AA H H E G N+NE +
Sbjct: 395 CIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
Query: 398 GTRYLNKSFVLGSYGPKKKEKGMGKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIE 457
+ +LG+ +E ++ K+ + L L F + D P E
Sbjct: 455 ASDMDRNKTILGNAHDNSEELERARELKEKEATLCL--------EFLLQNDANPSIRDKE 506
Query: 458 TYKNVTDSSRFNRDHPPEHPIQ-DDSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGI 516
Y ++ ++ + E ++ +S + DS S +++ G +L+ +S +
Sbjct: 507 GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLV 566
Query: 517 PVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL-WTPLHFACHAGQQDIVE 575
+D++D +T L A G+ + V+ L+ GA++ DN TPLH + G +
Sbjct: 567 DLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLR 626
Query: 576 LLVE---SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAM 628
LL+E + +D TPL A+ +D V LL+ A + G +A+
Sbjct: 627 LLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTAL 682
Score = 88.6 bits (218), Expect = 2e-17
Identities = 71/270 (26%), Positives = 114/270 (42%), Gaps = 43/270 (15%)
Query: 39 LINYTEPINGLSA-----LHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGH 93
LI+ TE +N L + LH+A+ D +++ L+ GA + +D M TP RA
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 94 ELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIF 153
E ++++L K AD+ D + L + + +CA + + + VN
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLH--VAAANKAVKCAEVIIPLLSSVN---------- 109
Query: 154 LRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNA 213
++ GRTAL A+ G VE+V +L +G +NA
Sbjct: 110 --------------------------VSDRGGRTALHHAALNGHVEMVNLLLAKGANINA 143
Query: 214 FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQR 273
FD A H+AA G D++ LL + +V G TPLH AA G + K++
Sbjct: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203
Query: 274 GCDLKWKNLDHKTPRAVAKEGGFKAASKEI 303
G ++ N+ T +A G A E+
Sbjct: 204 GVEIDEINVYGNTALHIACYNGQDAVVNEL 233
Score = 74.3 bits (181), Expect = 4e-13
Identities = 42/139 (30%), Positives = 76/139 (54%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V++ D +T L A +G++++V LL KGAN+NA D LH+A + G D+V LL
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Query: 578 VESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADY 637
+ GA + TPL+ A + +++ VK+LL++G + N G++A+ +A
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQD 227
Query: 638 RIIDLIKEKLDNLPKPAEN 656
+++ + + N+ +P N
Sbjct: 228 AVVNELIDYGANVNQPNNN 246
Score = 67.8 bits (164), Expect = 4e-11
Identities = 43/156 (27%), Positives = 79/156 (50%), Gaps = 1/156 (0%)
Query: 490 EKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGA 549
+K ++ ++ G + +K G+ +D + Y T L AC +G VV L++ GA
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
Query: 550 NVNATDNFLWTPLHFACHAGQQDI-VELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
NVN +N +TPLHFA + + +ELLV +GA ++ S + +PL+ R +
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIK 644
L+ G + ++ G++ + VA Y +I+ ++
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
Score = 63.9 bits (154), Expect = 5e-10
Identities = 36/133 (27%), Positives = 71/133 (53%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V+ D+ +TPL A G+ ++++ L+ GA VNA DN TPLH A + ++ V++L
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68
Query: 578 VESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADY 637
++ A ++A N TPL+ A + + + ++ + + + +R G +A+ A
Sbjct: 69 IKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHV 128
Query: 638 RIIDLIKEKLDNL 650
+++L+ K N+
Sbjct: 129 EMVNLLLAKGANI 141
Score = 63.2 bits (152), Expect = 9e-10
Identities = 40/136 (29%), Positives = 68/136 (50%), Gaps = 1/136 (0%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
G L + G V KD TPL A ++G I+VVK LL G ++ + + T L
Sbjct: 159 GHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTAL 218
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCR-LDTVKYLLDIGAKFQLEN 621
H AC+ GQ +V L++ GA ++ + N TPL+ A S ++ L++ GA +++
Sbjct: 219 HIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Query: 622 RKGHSAMDVAKAYADY 637
+ G S + + + +
Sbjct: 279 KDGKSPLHMTAVHGRF 294
Score = 60.8 bits (146), Expect = 5e-09
Identities = 51/186 (27%), Positives = 83/186 (44%), Gaps = 34/186 (18%)
Query: 488 DSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEK 547
DSEK + +++ GD ++ SG V+ KDN + TPL A AS + + V+ L++
Sbjct: 13 DSEKR-TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKH 71
Query: 548 GANVNATDNFLWTPLHFAC------------------------------HA---GQQDIV 574
A+VNA D TPLH A HA G ++V
Sbjct: 72 SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMV 131
Query: 575 ELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAY 634
LL+ GA I+A + L+ A LD V L++ GA+ +++KG++ + A +
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
Query: 635 ADYRII 640
++
Sbjct: 192 GQINVV 197
Score = 59.3 bits (142), Expect = 1e-08
Identities = 65/251 (25%), Positives = 98/251 (39%), Gaps = 23/251 (9%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCT--PTMRAAELGHELSMEILAKAKA 105
G +++H A+ + LL+ + G T P AA GH ++E+L ++
Sbjct: 507 GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLV 566
Query: 106 DMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKD 165
D+ I D +G+ L K H C + GA + K L A +
Sbjct: 567 DLDIRDEKGRTALDLAAF--KGHTECVEALINPGASIFVKDNVTKRTPLHA--SVINGHT 622
Query: 166 VCLTFL-EKGANPNAIN--SSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAA 222
+CL L E NP A++ + G+T LM A G ++ V +LE+ V+ D A
Sbjct: 623 LCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTAL 682
Query: 223 HFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFA--------------DCCK 268
H G + +++L + G TPLHYAA G A DCC
Sbjct: 683 HRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCF 742
Query: 269 YIAQRGCDLKW 279
Q L W
Sbjct: 743 KDNQGYTPLHW 753
Score = 58.5 bits (140), Expect = 2e-08
Identities = 68/272 (25%), Positives = 104/272 (38%), Gaps = 38/272 (13%)
Query: 37 PELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELS 96
PE ++ + G + L LA ID VS LL+ A+ D D +GCT R GHE
Sbjct: 635 PEAVDVKDA-KGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEEC 693
Query: 97 MEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALE-----------------HG 139
+++L + + + D+ G+ L Y + L+ + H
Sbjct: 694 VQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHW 753
Query: 140 ADVNNST--------------YEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINS--- 182
A N + + G P C +D + L GA ++I S
Sbjct: 754 ACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLL--GAIDSSIVSCRD 811
Query: 183 STGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLF-AYN 241
GRT L A+ VE ++ +L VNA DN A AA+ G + +L +
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQ 871
Query: 242 GDVGLISINGNTPLHYAAMGGFADCCKYIAQR 273
D+ + + NTPLH A G C I +
Sbjct: 872 ADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/162 (28%), Positives = 69/162 (42%), Gaps = 3/162 (1%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
G + + G ++ D + L A G++DVV L+ GA V D +TPL
Sbjct: 126 GHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPL 185
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
H A GQ ++V+ L+ G ID ++ +T L+ A + + V L+D GA N
Sbjct: 186 HAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNN 245
Query: 623 KGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
G + + A A L E L N Q GK+P
Sbjct: 246 NGFTPLHFAAASTHGA---LCLELLVNNGADVNIQSKDGKSP 284
Score = 57.4 bits (137), Expect = 5e-08
Identities = 44/169 (26%), Positives = 78/169 (46%), Gaps = 28/169 (16%)
Query: 509 KKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHA 568
+K SG +D D + +T L A A GN++ +K L GA+ + D TPLH+A
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAAN 423
Query: 569 GQQDIVELLVESGALID-------------AAS------------INNSTPLNRAIESCR 603
+E LV +GA ++ AAS +NS L RA E
Sbjct: 424 CHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKE 483
Query: 604 LDT---VKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDN 649
+ +++LL A + +++G++++ A AY + ++L+ E+ ++
Sbjct: 484 KEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532
Score = 55.5 bits (132), Expect = 2e-07
Identities = 63/238 (26%), Positives = 95/238 (39%), Gaps = 14/238 (5%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
S LHLA+ + + LL D++D G T AA GH +E L A + +
Sbjct: 544 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFV 603
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALE-----HGADVNNSTYEGKPIFLRACEDAHDVK 164
DN K + + H C + LE DV ++ + P+ L A+
Sbjct: 604 KDNVTKRTPLHASV-INGHTLCLRLLLEIADNPEAVDVKDAKGQ-TPLMLAV---AYGHI 658
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
D LEK AN + ++ G TAL G E V+ +LE+ + D+ H+
Sbjct: 659 DAVSLLLEKEANVDTVDI-LGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717
Query: 225 AAKGGFFDILKLLFAY---NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKW 279
AA G L L D G TPLH+A G +C + + ++ C K+
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKF 775
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/100 (32%), Positives = 52/100 (52%)
Query: 544 LLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCR 603
L+ K +VN D+ TPLH A G +I+ELL+ SGA ++A TPL+RA+ S
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 604 LDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
+ V+ L+ A ++ + + VA A + ++I
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
Score = 50.1 bits (118), Expect = 8e-06
Identities = 72/291 (24%), Positives = 108/291 (37%), Gaps = 57/291 (19%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHE---LSMEILAKAK 104
G +ALH A+ S D+D +L AH + ++ RA EL + L +E L +
Sbjct: 446 GRTALHYAAAS-DMDRNKTILG-NAHDNSEE------LERARELKEKEATLCLEFLLQND 497
Query: 105 ADMTIVDNEGKGVLFYCILPTKRHYRCALIALEH---GADVNNSTYEGKPIFLRACEDAH 161
A+ +I D EG + Y H +C + LE G + ++S P+ L A H
Sbjct: 498 ANPSIRDKEGYNSIHYAA--AYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHH 555
Query: 162 DVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHA 221
+V L L I GRTAL A+ +G E V ++ G + DN
Sbjct: 556 QALEVLLQSLVD----LDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRT 611
Query: 222 AHFA---------------------------AKG----------GFFDILKLLFAYNGDV 244
A AKG G D + LL +V
Sbjct: 612 PLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANV 671
Query: 245 GLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
+ I G T LH M G +C + + ++ + K+ +TP A G
Sbjct: 672 DTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARG 722
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/137 (24%), Positives = 60/137 (43%)
Query: 508 LKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACH 567
L+ +G V+++ K+PL G + L++ G ++ D TPLH A
Sbjct: 264 LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAAR 323
Query: 568 AGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSA 627
G + ++ L SGA I++ PL+ A + D + LL G + ++ G +
Sbjct: 324 YGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383
Query: 628 MDVAKAYADYRIIDLIK 644
+ A A + I L++
Sbjct: 384 LHAAAAGGNVECIKLLQ 400
Score = 49.3 bits (116), Expect = 1e-05
Identities = 37/135 (27%), Positives = 58/135 (42%)
Query: 528 PLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAA 587
PL A + + D + LL G ++ D F T LH A G + ++LL SGA
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 588 SINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKL 647
TPL+ A +C ++ L+ GA + G +A+ A A R ++
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAH 469
Query: 648 DNLPKPAENQKLKGK 662
DN + ++LK K
Sbjct: 470 DNSEELERARELKEK 484
Score = 46.6 bits (109), Expect = 9e-05
Identities = 39/130 (30%), Positives = 58/130 (44%), Gaps = 1/130 (0%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
II G+ ASL V +D+ +TPL A + +++ ++ LL A VNA DN
Sbjct: 787 IINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNS 846
Query: 558 LWTPLHFACHAGQQDIVELLVESG-ALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAK 616
T L A GQ V++LV S A + + +TPL+ A +LD
Sbjct: 847 GKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD 906
Query: 617 FQLENRKGHS 626
L N K ++
Sbjct: 907 ESLINEKNNA 916
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/150 (23%), Positives = 59/150 (39%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
S +++ G + ++G +D D TPL A G+ ++ L GA+
Sbjct: 283 SPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAK 342
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
PLH A D L+ SG ID T L+ A ++ +K L
Sbjct: 343 CGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402
Query: 614 GAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
GA F +++ G + + A A + I+ +
Sbjct: 403 GADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 4/90 (4%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNAT---DNFLWTPLHFACHAG 569
E + + KD+ +TPL A A G+ + LL+ + DN +TPLH+AC+ G
Sbjct: 699 EQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNG 758
Query: 570 QQDIVELLVESGALIDAASINNSTPLNRAI 599
++ +E+L+E N TPL+ AI
Sbjct: 759 NENCIEVLLEQKCFRKFIG-NPFTPLHCAI 787
Score = 37.7 bits (86), Expect = 0.041
Identities = 40/131 (30%), Positives = 56/131 (42%), Gaps = 36/131 (27%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD---------------------- 555
VD+KD +TPLM A A G+ID V LLEK ANV+ D
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697
Query: 556 -----NFLW------TPLHFACHAGQQD-IVELLVESGALIDAASINNS--TPLNRAIES 601
+ L TPLH+A G + ELL + + D +N TPL+ A +
Sbjct: 698 LEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYN 757
Query: 602 CRLDTVKYLLD 612
+ ++ LL+
Sbjct: 758 GNENCIEVLLE 768
Score = 37.0 bits (84), Expect = 0.070
Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 6/106 (5%)
Query: 204 ILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGF 263
++ + +VN D+++ H AA G +I++LL V TPLH A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 264 ADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERI 309
+ + + + D+ ++ + +TP VA AA+K ++ AE I
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVA------AANKAVKCAEVI 101
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 97.1 bits (240), Expect = 6e-20
Identities = 81/292 (27%), Positives = 129/292 (44%), Gaps = 40/292 (13%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
G + L +AS ++++V LLD G + +D G TP AA GH L E L + A
Sbjct: 814 GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGART 873
Query: 108 TIVDNEGKGVLFYCILPTKRHYRCALIALE------------------------------ 137
+DN+G+ + + + + HY C I LE
Sbjct: 874 NEIDNDGR--IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL 931
Query: 138 ---HGADVNNSTYEGKP-IFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEAS 193
HGADVN +G+P +++ A E+ + + FLE GAN A + + GRTAL +
Sbjct: 932 LFSHGADVNCKDADGRPTLYILALENQLTMAEY---FLENGANVEA-SDAEGRTALHVSC 987
Query: 194 REGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNT 253
+G +E+V+ ++ +VNA DN++ A AA G +++LL + V G T
Sbjct: 988 WQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT 1047
Query: 254 PLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRR 305
L AA G D + + + G D + +T VA + G K + +
Sbjct: 1048 ALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
Score = 92.0 bits (227), Expect = 2e-18
Identities = 66/240 (27%), Positives = 115/240 (47%), Gaps = 5/240 (2%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+G++ L +A+ +D+V LL+ GA D D G TP + AA +GH + L A
Sbjct: 747 DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ +D+EG+ VL I + + L+ G D N+ G A + H + +
Sbjct: 807 VDSIDSEGRTVL--SIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL--I 862
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
C +E+GA N I++ GR + AS+EG + V+ +LE ++ D +A AA
Sbjct: 863 CEALIEQGARTNEIDND-GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAA 921
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G DI++LLF++ DV +G L+ A+ +Y + G +++ + + +T
Sbjct: 922 LEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRT 981
Score = 83.6 bits (205), Expect = 7e-16
Identities = 73/254 (28%), Positives = 109/254 (42%), Gaps = 10/254 (3%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG + L A+ S +D+V+ L+ GA +++D G TP AA GH + L A+
Sbjct: 544 NGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGAN 603
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ D +G L H L G V+ + + + A H+ D+
Sbjct: 604 INHTDQDGWTALRSA--AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE--DI 659
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFA- 225
L L+ GA N ++ GRTAL+ A+ G EIV +L+ G EVN D D A A
Sbjct: 660 VLNLLQHGAEVNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718
Query: 226 ----AKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKN 281
A G ++ LL +V +G TPL AA G D + + G D+ +
Sbjct: 719 LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778
Query: 282 LDHKTPRAVAKEGG 295
+ +TP A G
Sbjct: 779 NNGRTPLLAAASMG 792
Score = 80.1 bits (196), Expect = 7e-15
Identities = 68/250 (27%), Positives = 117/250 (46%), Gaps = 8/250 (3%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
+AL A+ D+V LL GA + D G T + AA +GH +E L A++
Sbjct: 646 TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNH 705
Query: 110 VDNEGK---GVLFYCILPTKRHYRCALIALEHGADVNNSTYEGK-PIFLRACEDAHDVKD 165
D +G+ V C+ +K H + ++ GA+V++ +G P+ + A E DV D
Sbjct: 706 EDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD 765
Query: 166 VCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFA 225
+ LE GA+ + +++ GRT L+ A+ G +V +L G V++ D++ A
Sbjct: 766 L---LLEGGADVDHTDNN-GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821
Query: 226 AKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
+ G ++++ L D G TPLH AA G C+ + ++G + D +
Sbjct: 822 SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881
Query: 286 TPRAVAKEGG 295
P +A + G
Sbjct: 882 IPFILASQEG 891
Score = 76.6 bits (187), Expect = 8e-14
Identities = 76/257 (29%), Positives = 111/257 (43%), Gaps = 19/257 (7%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGA---HPDVQDRMG------CTPTMRAAELGHELSME 98
G +AL A+ ++V LLD GA H DV R C P A GH +
Sbjct: 677 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP----ASKGHASVVS 732
Query: 99 ILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACE 158
+L A++ D +G L + + H + LE GADV+++ G+ L A
Sbjct: 733 LLIDRGAEVDHCDKDGMTPLL--VAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAAS 790
Query: 159 DAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDR 218
H V T L GA ++I+S GRT L AS +G VE+VR +L+RG + N D+
Sbjct: 791 MGH--ASVVNTLLFWGAAVDSIDSE-GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
Query: 219 HHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLK 278
H AA G I + L I +G P A+ G DC + + + ++
Sbjct: 848 WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID 907
Query: 279 WKNLDHKTP-RAVAKEG 294
+ D + R A EG
Sbjct: 908 QRGYDGRNALRVAALEG 924
Score = 73.9 bits (180), Expect = 5e-13
Identities = 74/281 (26%), Positives = 119/281 (42%), Gaps = 7/281 (2%)
Query: 40 INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
IN+T+ +G +AL A+ ++VS LL G D D T AA GHE +
Sbjct: 604 INHTDQ-DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 662
Query: 100 LAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACED 159
L + A++ DNEG+ L H L+HGA+VN+ +G+ A
Sbjct: 663 LLQHGAEVNKADNEGRTALIAAAY--MGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720
Query: 160 AHDVK---DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDN 216
K V +++GA + + G T L+ A+ EG V++V +LE G +V+ DN
Sbjct: 721 VPASKGHASVVSLLIDRGAEVDHCDKD-GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDN 779
Query: 217 DRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCD 276
+ AA G ++ L + V I G T L A+ G + + + RG D
Sbjct: 780 NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
Query: 277 LKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPG 317
++ TP +A G + + + N++ G
Sbjct: 840 ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Score = 71.6 bits (174), Expect = 3e-12
Identities = 71/257 (27%), Positives = 109/257 (42%), Gaps = 10/257 (3%)
Query: 44 EPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKA 103
E +G + L LA+ +V+ L+ GA+ + D+ G T AA GH + L A
Sbjct: 574 EDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633
Query: 104 KADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDV 163
+ D + + L H L L+HGA+VN + EG+ + A H
Sbjct: 634 GVKVDCADADSRTAL--RAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGH-- 689
Query: 164 KDVCLTFLEKGANPNAINSSTGRTALMEA-----SREGVVEIVRGILERGGEVNAFDNDR 218
+++ L+ GA N GRTAL A + +G +V +++RG EV+ D D
Sbjct: 690 REIVEHLLDHGAEVNH-EDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG 748
Query: 219 HHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLK 278
AA G D++ LL DV NG TPL AA G A + G +
Sbjct: 749 MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVD 808
Query: 279 WKNLDHKTPRAVAKEGG 295
+ + +T ++A G
Sbjct: 809 SIDSEGRTVLSIASAQG 825
Score = 70.1 bits (170), Expect = 7e-12
Identities = 45/148 (30%), Positives = 74/148 (50%), Gaps = 3/148 (2%)
Query: 502 AGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
+G L + G ++++D + TPL A G+ VV L+ GAN+N TD WT
Sbjct: 555 SGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTA 614
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L A G ++V L+ +G +D A ++ T L A D V LL GA+ +
Sbjct: 615 LRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKAD 674
Query: 622 RKGHSAMDVAKAYADYRIIDLIKEKLDN 649
+G +A+ +A AY +R ++++ LD+
Sbjct: 675 NEGRTAL-IAAAYMGHR--EIVEHLLDH 699
Score = 69.7 bits (169), Expect = 1e-11
Identities = 42/129 (32%), Positives = 64/129 (49%)
Query: 515 GIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIV 574
G VD D+ +T L A A GN++VV+ LL++G + N D+ WTPLH A G + I
Sbjct: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC 863
Query: 575 ELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAY 634
E L+E GA + + P A + D V+ LL+ + G +A+ VA
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923
Query: 635 ADYRIIDLI 643
I++L+
Sbjct: 924 GHRDIVELL 932
Score = 69.7 bits (169), Expect = 1e-11
Identities = 65/209 (31%), Positives = 102/209 (48%), Gaps = 11/209 (5%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSM-EILAKAKA 105
+G +AL +A++ D+V L GA + +D G PT+ L ++L+M E + A
Sbjct: 912 DGRNALRVAALEGHRDIVELLFSHGADVNCKDADG-RPTLYILALENQLTMAEYFLENGA 970
Query: 106 DMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKD 165
++ D EG+ L + + H + + + ADVN + E + A H VK
Sbjct: 971 NVEASDAEGRTALH--VSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH-VKV 1027
Query: 166 VCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFA 225
V L +E GA + + G TAL A++EG +++V+ +LE G + N D A A
Sbjct: 1028 VQL-LIEHGAVVDH-TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
Query: 226 AKGGFFDILKLLFAYNGDVGLISINGNTP 254
AK G I+KLL Y G S+NG +P
Sbjct: 1086 AKNGHSQIIKLLEKY----GASSLNGCSP 1110
Score = 69.3 bits (168), Expect = 1e-11
Identities = 45/148 (30%), Positives = 76/148 (51%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
I+ L + E+G V+ D +T L +C G++++V+ L+ A+VNA DN
Sbjct: 952 ILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE 1011
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
+ L A G +V+LL+E GA++D +T L A + +D V+ LL+ GA
Sbjct: 1012 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADP 1071
Query: 618 QLENRKGHSAMDVAKAYADYRIIDLIKE 645
++ G +AM VA +II L+++
Sbjct: 1072 NHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
Score = 64.7 bits (156), Expect = 3e-10
Identities = 45/138 (32%), Positives = 68/138 (49%), Gaps = 1/138 (0%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
G + + + G VD D TPL+ A G++DVV LLE GA+V+ TDN TPL
Sbjct: 726 GHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL 785
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
A G +V L+ GA +D+ T L+ A ++ V+ LLD G +
Sbjct: 786 LAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 845
Query: 623 KGHSAMDVAKAYADYRII 640
G + + +A A+ +R+I
Sbjct: 846 AGWTPLHMA-AFEGHRLI 862
Score = 61.2 bits (147), Expect = 3e-09
Identities = 40/139 (28%), Positives = 66/139 (47%), Gaps = 5/139 (3%)
Query: 513 ESGIPVDMKDNYYKTPLMTAC-----ASGNIDVVKFLLEKGANVNATDNFLWTPLHFACH 567
+ G V+ +D +T L A + G+ VV L+++GA V+ D TPL A +
Sbjct: 698 DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757
Query: 568 AGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSA 627
G D+V+LL+E GA +D N TPL A V LL GA + +G +
Sbjct: 758 EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTV 817
Query: 628 MDVAKAYADYRIIDLIKEK 646
+ +A A + ++ + ++
Sbjct: 818 LSIASAQGNVEVVRTLLDR 836
Score = 60.5 bits (145), Expect = 6e-09
Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 9/236 (3%)
Query: 57 VSNDIDMVSFLLDLGAHPDVQD-RMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGK 115
+ + +++ L+ GAH + +D R C +R A L E S+ L A + D+ G+
Sbjct: 490 IPKEQEVLQLLVKAGAHVNSEDDRTSCI--VRQA-LEREDSIRTLLDNGASVNQCDSNGR 546
Query: 116 GVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGA 175
+L L++ GAD+ G A H CL + GA
Sbjct: 547 TLLANAAYSGSLDVVNLLVS--RGADLEIEDAHGHTPLTLAARQGHTKVVNCL--IGCGA 602
Query: 176 NPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILK 235
N N + G TAL A+ G E+V +L G +V+ D D A AA GG DI+
Sbjct: 603 NINHTDQD-GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661
Query: 236 LLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVA 291
L + +V G T L AA G + +++ G ++ +++D +T +VA
Sbjct: 662 NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
Score = 60.1 bits (144), Expect = 8e-09
Identities = 70/261 (26%), Positives = 114/261 (43%), Gaps = 24/261 (9%)
Query: 514 SGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDI 573
+G+ VD D +T L A G+ D+V LL+ GA VN DN T L A + G ++I
Sbjct: 633 AGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREI 692
Query: 574 VELLVESGALIDAASINNSTPLNRA-----IESCRLDTVKYLLDIGAKFQLENRKGHSAM 628
VE L++ GA ++ ++ T L+ A V L+D GA+ ++ G + +
Sbjct: 693 VEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPL 752
Query: 629 DVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVP 688
VA ++DL+ E ++ N G+TP + LL V
Sbjct: 753 LVAAYEGHVDVVDLLLEGGADVDHTDNN----GRTPLLAAASMGHASVVNTLLFWGAAVD 808
Query: 689 T-TSEGKKV-----QKGNVVHLNSLITSGYTKKVDITFIPRRIWSPEATTA----ELIRK 738
+ SEG+ V +GNV + +L+ G +D W+P A LI +
Sbjct: 809 SIDSEGRTVLSIASAQGNVEVVRTLLDRG----LDENHRDDAGWTPLHMAAFEGHRLICE 864
Query: 739 RELRRERFTHEVDFDDFMMPF 759
+ + T+E+D +D +PF
Sbjct: 865 ALIEQGARTNEID-NDGRIPF 884
Score = 54.7 bits (130), Expect = 3e-07
Identities = 41/162 (25%), Positives = 71/162 (43%), Gaps = 5/162 (3%)
Query: 134 IALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEAS 193
+ ++ GA VN+ I +A E ++ T L+ GA+ N +S+ GRT L A+
Sbjct: 499 LLVKAGAHVNSEDDRTSCIVRQALEREDSIR----TLLDNGASVNQCDSN-GRTLLANAA 553
Query: 194 REGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNT 253
G +++V ++ RG ++ D H AA+ G ++ L ++ +G T
Sbjct: 554 YSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWT 613
Query: 254 PLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
L AA GG + + G + + D +T A GG
Sbjct: 614 ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGG 655
Score = 53.5 bits (127), Expect = 7e-07
Identities = 42/162 (25%), Positives = 68/162 (41%), Gaps = 3/162 (1%)
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
L++GA VN G+ + A DV + +GA+ I + G T L A+R+
Sbjct: 532 LDNGASVNQCDSNGRTLLANAAYSGS--LDVVNLLVSRGADLE-IEDAHGHTPLTLAARQ 588
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G ++V ++ G +N D D A AA GG +++ L V + T L
Sbjct: 589 GHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTAL 648
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFK 297
AA GG D + Q G ++ + + +T A G +
Sbjct: 649 RAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHR 690
Score = 50.1 bits (118), Expect = 8e-06
Identities = 33/92 (35%), Positives = 46/92 (50%), Gaps = 4/92 (4%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
G + ++ E G VD N T L A G+IDVV+ LLE GA+ N D F T +
Sbjct: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAM 1082
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTP 594
A G I++LL + G A+S+N +P
Sbjct: 1083 RVAAKNGHSQIIKLLEKYG----ASSLNGCSP 1110
Score = 49.7 bits (117), Expect = 1e-05
Identities = 40/148 (27%), Positives = 72/148 (48%), Gaps = 5/148 (3%)
Query: 482 SVWYIDDSEKVFSNIN-IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDV 540
++W I + V +++ +I K ++ L ++G V+ +D+ +T + A D
Sbjct: 472 ALWMIWNGTPVRDSLSTLIPKEQEVLQL--LVKAGAHVNSEDD--RTSCIVRQALEREDS 527
Query: 541 VKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIE 600
++ LL+ GA+VN D+ T L A ++G D+V LLV GA ++ + TPL A
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 601 SCRLDTVKYLLDIGAKFQLENRKGHSAM 628
V L+ GA ++ G +A+
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGWTAL 615
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/133 (24%), Positives = 60/133 (45%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++I + G++ ++ + G+ + +D+ TPL A G+ + + L+E+GA N D
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
N P A G D V++L+E+ + ID + L A D V+ L GA
Sbjct: 878 NDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
Query: 616 KFQLENRKGHSAM 628
++ G +
Sbjct: 938 DVNCKDADGRPTL 950
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/98 (32%), Positives = 50/98 (51%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V+ DN ++ L +A G++ VV+ L+E GA V+ T N T L A G D+V++L
Sbjct: 1005 VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Query: 578 VESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+E GA + A T + A ++ +K L GA
Sbjct: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Score = 43.9 bits (102), Expect = 6e-04
Identities = 31/148 (20%), Positives = 64/148 (43%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
+ ++ G ++ E+ +D + + L A G+ D+V+ L GA+VN D
Sbjct: 886 LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDAD 945
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
L+ Q + E +E+GA ++A+ T L+ + ++ V+ L+ A
Sbjct: 946 GRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADV 1005
Query: 618 QLENRKGHSAMDVAKAYADYRIIDLIKE 645
+ + SA+ A +++ L+ E
Sbjct: 1006 NAADNEKRSALQSAAWQGHVKVVQLLIE 1033
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 94.4 bits (233), Expect = 4e-19
Identities = 83/299 (27%), Positives = 137/299 (45%), Gaps = 24/299 (8%)
Query: 38 ELINYTEPIN-----GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELG 92
EL+NY +N G + L++A+ N +++V FLL+ GA+ +V G TP A + G
Sbjct: 129 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 188
Query: 93 HELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRH-YRCALIALEHGADVNNSTYEG-K 150
HE A + +GK L + + R A + L++ + + + G
Sbjct: 189 HE-------NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 241
Query: 151 PIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGE 210
P+ + A ++ +V L +GA+ N G T L ASR G V +VR +L+RG +
Sbjct: 242 PLHIAA---HYENLNVAQLLLNRGASVN-FTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297
Query: 211 VNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYI 270
+ D H AA+ G I ++L + + + NG +P+H AA G DC + +
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357
Query: 271 AQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
Q ++ LDH TP VA G R A+ + +K A+P ++ N L +
Sbjct: 358 LQYDAEIDDITLDHLTPLHVAAHCGHH------RVAKVLLDKGAKPNSRALNGFTPLHI 410
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/352 (26%), Positives = 140/352 (39%), Gaps = 70/352 (19%)
Query: 40 INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
+N+T P NG++ LH+AS ++ MV LLD GA + + + TP AA GH EI
Sbjct: 265 VNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 323
Query: 100 L--------AKAKADMTIVDNEGKGVLFYCILPTKR-----------------------H 128
L AK K ++ + +G C+ + H
Sbjct: 324 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 383
Query: 129 YRCALIALEHGADVNNSTYEGKPIFLRACEDAH---------------DVKDVCLT---- 169
+R A + L+ GA N+ G AC+ H V + LT
Sbjct: 384 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 443
Query: 170 ------------FLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
L++GA+PN N T L A+R G E+ + +L+ +VNA D
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 502
Query: 218 RHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
H AA+ G +++KLL N + L + G+TPLH AA G + + ++
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562
Query: 278 KWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
TP VA + G ++R AE + + A P A N L L +
Sbjct: 563 ACMTKKGFTPLHVAAKYG------KVRVAELLLERDAHPNAAGKNGLTPLHV 608
Score = 79.7 bits (195), Expect = 9e-15
Identities = 72/249 (28%), Positives = 108/249 (43%), Gaps = 5/249 (2%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+GL+ LH+AS + +V LL GA P+V + TP AA GH + L + KA
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 495
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ + + L +C H + LE+ A+ N +T G A + H +
Sbjct: 496 VNAKAKDDQTPL-HCAARIG-HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH--VET 551
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L LEK A+ A + G T L A++ G V + +LER NA + H A
Sbjct: 552 VLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 610
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
DI+KLL G + NG TPLH AA + + + Q G +++ T
Sbjct: 611 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 670
Query: 287 PRAVAKEGG 295
P +A + G
Sbjct: 671 PLHLAAQEG 679
Score = 76.3 bits (186), Expect = 1e-13
Identities = 47/158 (29%), Positives = 82/158 (51%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+E + +++ + G L +K + G ++ + +TPL A +G+ +V K+LL+
Sbjct: 434 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A VNA TPLH A G ++V+LL+E+ A + A+ TPL+ A ++TV
Sbjct: 494 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 553
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
LL+ A +KG + + VA Y R+ +L+ E+
Sbjct: 554 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 591
Score = 72.4 bits (176), Expect = 2e-12
Identities = 63/250 (25%), Positives = 106/250 (42%), Gaps = 7/250 (2%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGH-ELSMEILAKAKAD 106
G + LH+A+ + + LL+ AHP+ + G TP A + ++ +L + +
Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ N G I + A L++G N + +G A ++ H ++
Sbjct: 629 HSPAWN---GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH--AEM 683
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L K AN N N S G T L ++EG V + +++ G V+A + H A+
Sbjct: 684 VALLLSKQANGNLGNKS-GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G ++K L + DV + G +PLH AA G D + + G + D T
Sbjct: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 802
Query: 287 PRAVAKEGGF 296
P A+AK G+
Sbjct: 803 PLAIAKRLGY 812
Score = 71.6 bits (174), Expect = 3e-12
Identities = 42/154 (27%), Positives = 79/154 (51%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
F+ ++I K + ++ ++G +D TPL A G++ +VK LL++GA+ N
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
++ + TPLH A AG ++ + L+++ A ++A + ++ TPL+ A + VK LL+
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
A L GH+ + +A + + EK
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/204 (26%), Positives = 92/204 (45%), Gaps = 4/204 (1%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+ F+ ++I +L + G V+ TPL A GN+ +V+ LL++G
Sbjct: 236 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 295
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A + TPLH A G I E+L++ GA I A + N +P++ A + LD V+
Sbjct: 296 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 355
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILK 668
LL A+ + + VA +R+ ++ LD KP ++ L G TP +
Sbjct: 356 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL---LDKGAKP-NSRALNGFTPLHIA 411
Query: 669 TEGPEIKKEEELLSSIYGVPTTSE 692
+ ++ E LL + + +E
Sbjct: 412 CKKNHVRVMELLLKTGASIDAVTE 435
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/140 (36%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G+ V K LL+KGA N+ +TPLH AC ++ELL+++GA IDA
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ + TPL+ A L VK LL GA + N K + + +A A A + ++ K
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA-ARAGH--TEVAKYL 489
Query: 647 LDNLPKPAENQKLKGKTPPI 666
L N K N K K P+
Sbjct: 490 LQN--KAKVNAKAKDDQTPL 507
Score = 63.9 bits (154), Expect = 5e-10
Identities = 36/100 (36%), Positives = 55/100 (55%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++++ + G + + G+ VD TPL A GNI +VKFLL+ A+VNA
Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPL 595
++PLH A G DIV LL+++GA + S + +TPL
Sbjct: 765 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804
Score = 63.5 bits (153), Expect = 7e-10
Identities = 48/160 (30%), Positives = 73/160 (45%), Gaps = 11/160 (6%)
Query: 44 EPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKA 103
E + G++ LHLA+ +MV+ LL A+ ++ ++ G TP A+ GH ++L K
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 104 KADMTIVDNEGKGVLFYCILPTKRHY---RCALIALEHGADVNNSTYEGKPIFLRACEDA 160
+ G Y L HY + L+H ADVN T G +A +
Sbjct: 724 GVMVDATTRMG-----YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 778
Query: 161 HDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEI 200
H D+ L+ GA+PN + SS G T L A R G + +
Sbjct: 779 H--TDIVTLLLKNGASPNEV-SSDGTTPLAIAKRLGYISV 815
Score = 61.6 bits (148), Expect = 3e-09
Identities = 36/123 (29%), Positives = 61/123 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL AC ++ V++ LL+ GA+++A TPLH A G IV+ L++ GA +
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+++ TPL+ A + + KYLL AK + + + + A ++ L+ E
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 525
Query: 647 LDN 649
N
Sbjct: 526 NAN 528
Score = 60.8 bits (146), Expect = 5e-09
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 8/214 (3%)
Query: 491 KVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGAN 550
KV + +++ +AG K ++ V+ K +TPL A G+ ++VK LLE AN
Sbjct: 469 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528
Query: 551 VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610
N TPLH A G + V L+E A + TPL+ A + ++ + L
Sbjct: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 588
Query: 611 LDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTE 670
L+ A + G + + VA + + I+ L+ + + PA N G TP + +
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN----GYTPLHIAAK 644
Query: 671 GPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHL 704
+++ LL YG +E VQ +HL
Sbjct: 645 QNQVEVARSLLQ--YGGSANAE--SVQGVTPLHL 674
Score = 60.8 bits (146), Expect = 5e-09
Identities = 38/123 (30%), Positives = 60/123 (48%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G + V + LLE+ A+ NA TPLH A H DIV+LL+ G +
Sbjct: 571 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ N TPL+ A + +++ + LL G E+ +G + + +A ++ L+ K
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 690
Query: 647 LDN 649
N
Sbjct: 691 QAN 693
Score = 60.8 bits (146), Expect = 5e-09
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 4/172 (2%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
++ ++I K + + + G + + TPL A G+ ++V LL K AN N
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
+ TPLH G + ++L++ G ++DA + TPL+ A + VK+LL
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
A + + G+S + A I+ L+ L N P E G TP
Sbjct: 756 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPNEVSS-DGTTP 803
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/223 (25%), Positives = 93/223 (41%), Gaps = 10/223 (4%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++ + G +K E+ ++ TPL A G+++ V LLEK A+
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPLH A G+ + ELL+E A +AA N TPL+ A+ LD VK LL G
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
Query: 616 KFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
G++ + +A A +++ + L A + ++G TP L + +
Sbjct: 627 SPHSPAWNGYTPLHIA---AKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAE 682
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDI 718
LLS + G K + L+ + G+ D+
Sbjct: 683 MVALLLSK------QANGNLGNKSGLTPLHLVAQEGHVPVADV 719
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/122 (29%), Positives = 60/122 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL G++ V L++ G V+AT +TPLH A H G +V+ L++ A ++A
Sbjct: 703 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 762
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ +PL++A + D V LL GA + G + + +AK + D++K
Sbjct: 763 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 822
Query: 647 LD 648
D
Sbjct: 823 TD 824
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/224 (24%), Positives = 101/224 (45%), Gaps = 14/224 (6%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
+ +++ +K G + + + I ++ T L A +G +VV+ L+ GANVNA
Sbjct: 80 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 139
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+TPL+ A ++V+ L+E+GA + A+ + TPL A++ + V +L++
Sbjct: 140 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199
Query: 614 GAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPE 673
G K ++ A+ +A D R ++ L N P P K G TP +
Sbjct: 200 GTKGKVR----LPALHIAARNDDTRTAAVL---LQNDPNPDVLSK-TGFTPLHIAAHYEN 251
Query: 674 IKKEEELLSSIYGVPTTSEGK------KVQKGNVVHLNSLITSG 711
+ + LL+ V T + ++GNV+ + L+ G
Sbjct: 252 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 295
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/155 (24%), Positives = 70/155 (45%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
++K F+ +++ K G + + E + TPL A N+D+VK LL +G
Sbjct: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
+ ++ +TPLH A Q ++ L++ G +A S+ TPL+ A + + V
Sbjct: 626 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 685
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
LL A L N+ G + + + + D++
Sbjct: 686 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/119 (26%), Positives = 58/119 (48%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ G P+ K +P+ A ++D V+ LL+ A ++ TPLH A H G
Sbjct: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 385
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
+ ++L++ GA ++ ++N TPL+ A + + ++ LL GA G + + VA
Sbjct: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 444
Score = 57.0 bits (136), Expect = 7e-08
Identities = 39/131 (29%), Positives = 62/131 (47%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
++G+L +G+ ++ + L A G++ +V LL K + T T
Sbjct: 54 RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNT 113
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
LH A AGQ ++V LV GA ++A S TPL A + L+ VK+LL+ GA +
Sbjct: 114 ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 173
Query: 621 NRKGHSAMDVA 631
G + + VA
Sbjct: 174 TEDGFTPLAVA 184
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/143 (30%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
FLRA + D L L G + N N + G L AS+EG V++V +L + +
Sbjct: 49 FLRAARSGN--LDKALDHLRNGVDINTCNQN-GLNGLHLASKEGHVKMVVELLHKEIILE 105
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ A H AA G ++++ L Y +V S G TPL+ AA + K++ +
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
Query: 273 RGCDLKWKNLDHKTPRAVAKEGG 295
G + D TP AVA + G
Sbjct: 166 NGANQNVATEDGFTPLAVALQQG 188
Score = 47.4 bits (111), Expect = 5e-05
Identities = 47/215 (21%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+K F+ + + + L +K E+G ++ TPL A G+ +VV L+ G
Sbjct: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Query: 549 A-----------------------------NVNATDNFLWTPLHFACHAGQQDIVELLVE 579
N + +TPLH A H ++ +LL+
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260
Query: 580 SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRI 639
GA ++ N TPL+ A + V+ LLD GA+ + + + + + A RI
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 320
Query: 640 IDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEI 674
+++ LD+ P + + G +P + +G +
Sbjct: 321 SEIL---LDH-GAPIQAKTKNGLSPIHMAAQGDHL 351
Score = 38.9 bits (89), Expect = 0.018
Identities = 44/195 (22%), Positives = 81/195 (41%), Gaps = 19/195 (9%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
++ +++ + G++ +K + V+ K +PL A G+ D+V LL+ GA+ N
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRL---DTVKY 609
+ TPL A G + ++L + + T + R+ +TV
Sbjct: 795 EVSSDGTTPLAIAKRLGYISVTDVL---------KVVTDETSFVLVSDKHRMSFPETVDE 845
Query: 610 LLDIGAKFQLEN--RKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPIL 667
+LD+ + G + D R +D KE LD +PK +Q ++ P +
Sbjct: 846 ILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPK--LDQVVESPAIPRI 903
Query: 668 KTEGPE---IKKEEE 679
PE I+ EE+
Sbjct: 904 PCAMPETVVIRSEEQ 918
Score = 36.6 bits (83), Expect = 0.091
Identities = 24/107 (22%), Positives = 49/107 (45%)
Query: 187 TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGL 246
T+ + A+R G ++ L G ++N + + + H A+K G ++ L +
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
Query: 247 ISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKE 293
+ GNT LH AA+ G + + + G ++ ++ TP +A +
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 153
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 94.4 bits (233), Expect = 4e-19
Identities = 83/299 (27%), Positives = 137/299 (45%), Gaps = 24/299 (8%)
Query: 38 ELINYTEPIN-----GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELG 92
EL+NY +N G + L++A+ N +++V FLL+ GA+ +V G TP A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 93 HELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRH-YRCALIALEHGADVNNSTYEG-K 150
HE A + +GK L + + R A + L++ + + + G
Sbjct: 156 HE-------NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 208
Query: 151 PIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGE 210
P+ + A ++ +V L +GA+ N G T L ASR G V +VR +L+RG +
Sbjct: 209 PLHIAA---HYENLNVAQLLLNRGASVN-FTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 211 VNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYI 270
+ D H AA+ G I ++L + + + NG +P+H AA G DC + +
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 271 AQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
Q ++ LDH TP VA G R A+ + +K A+P ++ N L +
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHH------RVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/352 (26%), Positives = 140/352 (39%), Gaps = 70/352 (19%)
Query: 40 INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
+N+T P NG++ LH+AS ++ MV LLD GA + + + TP AA GH EI
Sbjct: 232 VNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 100 L--------AKAKADMTIVDNEGKGVLFYCILPTKR-----------------------H 128
L AK K ++ + +G C+ + H
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 129 YRCALIALEHGADVNNSTYEGKPIFLRACEDAH---------------DVKDVCLT---- 169
+R A + L+ GA N+ G AC+ H V + LT
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
Query: 170 ------------FLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
L++GA+PN N T L A+R G E+ + +L+ +VNA D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 469
Query: 218 RHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
H AA+ G +++KLL N + L + G+TPLH AA G + + ++
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 278 KWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
TP VA + G ++R AE + + A P A N L L +
Sbjct: 530 ACMTKKGFTPLHVAAKYG------KVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 79.7 bits (195), Expect = 9e-15
Identities = 72/249 (28%), Positives = 108/249 (43%), Gaps = 5/249 (2%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+GL+ LH+AS + +V LL GA P+V + TP AA GH + L + KA
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ + + L +C H + LE+ A+ N +T G A + H +
Sbjct: 463 VNAKAKDDQTPL-HCAARIG-HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH--VET 518
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L LEK A+ A + G T L A++ G V + +LER NA + H A
Sbjct: 519 VLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
DI+KLL G + NG TPLH AA + + + Q G +++ T
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637
Query: 287 PRAVAKEGG 295
P +A + G
Sbjct: 638 PLHLAAQEG 646
Score = 76.3 bits (186), Expect = 1e-13
Identities = 47/158 (29%), Positives = 82/158 (51%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+E + +++ + G L +K + G ++ + +TPL A +G+ +V K+LL+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A VNA TPLH A G ++V+LL+E+ A + A+ TPL+ A ++TV
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 520
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
LL+ A +KG + + VA Y R+ +L+ E+
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558
Score = 72.4 bits (176), Expect = 2e-12
Identities = 63/250 (25%), Positives = 106/250 (42%), Gaps = 7/250 (2%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGH-ELSMEILAKAKAD 106
G + LH+A+ + + LL+ AHP+ + G TP A + ++ +L + +
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ N G I + A L++G N + +G A ++ H ++
Sbjct: 596 HSPAWN---GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH--AEM 650
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L K AN N N S G T L ++EG V + +++ G V+A + H A+
Sbjct: 651 VALLLSKQANGNLGNKS-GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G ++K L + DV + G +PLH AA G D + + G + D T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 287 PRAVAKEGGF 296
P A+AK G+
Sbjct: 770 PLAIAKRLGY 779
Score = 71.6 bits (174), Expect = 3e-12
Identities = 42/154 (27%), Positives = 79/154 (51%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
F+ ++I K + ++ ++G +D TPL A G++ +VK LL++GA+ N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
++ + TPLH A AG ++ + L+++ A ++A + ++ TPL+ A + VK LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
A L GH+ + +A + + EK
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/204 (26%), Positives = 92/204 (45%), Gaps = 4/204 (1%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+ F+ ++I +L + G V+ TPL A GN+ +V+ LL++G
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A + TPLH A G I E+L++ GA I A + N +P++ A + LD V+
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILK 668
LL A+ + + VA +R+ ++ LD KP ++ L G TP +
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL---LDKGAKP-NSRALNGFTPLHIA 378
Query: 669 TEGPEIKKEEELLSSIYGVPTTSE 692
+ ++ E LL + + +E
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTE 402
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/140 (36%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G+ V K LL+KGA N+ +TPLH AC ++ELL+++GA IDA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ + TPL+ A L VK LL GA + N K + + +A A A + ++ K
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA-ARAGH--TEVAKYL 456
Query: 647 LDNLPKPAENQKLKGKTPPI 666
L N K N K K P+
Sbjct: 457 LQN--KAKVNAKAKDDQTPL 474
Score = 64.3 bits (155), Expect = 4e-10
Identities = 57/208 (27%), Positives = 90/208 (43%), Gaps = 26/208 (12%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++++ + G + + G+ VD TPL A GNI +VKFLL+ A+VNA
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPL---NRAIESCRLDTVKYLLD 612
++PLH A G DIV LL+++GA + S + +TPL R D +K + D
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
Query: 613 ------------------IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPA 654
+ + +G + D R +D KE LD +PK
Sbjct: 792 ETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPK-- 849
Query: 655 ENQKLKGKTPPILKTEGPE---IKKEEE 679
+Q ++ P + PE I+ EE+
Sbjct: 850 LDQVVESPAIPRIPCAMPETVVIRSEEQ 877
Score = 63.5 bits (153), Expect = 7e-10
Identities = 48/160 (30%), Positives = 73/160 (45%), Gaps = 11/160 (6%)
Query: 44 EPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKA 103
E + G++ LHLA+ +MV+ LL A+ ++ ++ G TP A+ GH ++L K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 104 KADMTIVDNEGKGVLFYCILPTKRHY---RCALIALEHGADVNNSTYEGKPIFLRACEDA 160
+ G Y L HY + L+H ADVN T G +A +
Sbjct: 691 GVMVDATTRMG-----YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745
Query: 161 HDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEI 200
H D+ L+ GA+PN + SS G T L A R G + +
Sbjct: 746 H--TDIVTLLLKNGASPNEV-SSDGTTPLAIAKRLGYISV 782
Score = 61.6 bits (148), Expect = 3e-09
Identities = 36/123 (29%), Positives = 61/123 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL AC ++ V++ LL+ GA+++A TPLH A G IV+ L++ GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+++ TPL+ A + + KYLL AK + + + + A ++ L+ E
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 647 LDN 649
N
Sbjct: 493 NAN 495
Score = 60.8 bits (146), Expect = 5e-09
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 8/214 (3%)
Query: 491 KVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGAN 550
KV + +++ +AG K ++ V+ K +TPL A G+ ++VK LLE AN
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 551 VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610
N TPLH A G + V L+E A + TPL+ A + ++ + L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Query: 611 LDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTE 670
L+ A + G + + VA + + I+ L+ + + PA N G TP + +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN----GYTPLHIAAK 611
Query: 671 GPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHL 704
+++ LL YG +E VQ +HL
Sbjct: 612 QNQVEVARSLLQ--YGGSANAE--SVQGVTPLHL 641
Score = 60.8 bits (146), Expect = 5e-09
Identities = 38/123 (30%), Positives = 60/123 (48%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G + V + LLE+ A+ NA TPLH A H DIV+LL+ G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ N TPL+ A + +++ + LL G E+ +G + + +A ++ L+ K
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 647 LDN 649
N
Sbjct: 658 QAN 660
Score = 60.8 bits (146), Expect = 5e-09
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 4/172 (2%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
++ ++I K + + + G + + TPL A G+ ++V LL K AN N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
+ TPLH G + ++L++ G ++DA + TPL+ A + VK+LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
A + + G+S + A I+ L+ L N P E G TP
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPNEVSS-DGTTP 770
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/223 (25%), Positives = 93/223 (41%), Gaps = 10/223 (4%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++ + G +K E+ ++ TPL A G+++ V LLEK A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPLH A G+ + ELL+E A +AA N TPL+ A+ LD VK LL G
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 616 KFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
G++ + +A A +++ + L A + ++G TP L + +
Sbjct: 594 SPHSPAWNGYTPLHIA---AKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDI 718
LLS + G K + L+ + G+ D+
Sbjct: 650 MVALLLSK------QANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/122 (29%), Positives = 60/122 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL G++ V L++ G V+AT +TPLH A H G +V+ L++ A ++A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ +PL++A + D V LL GA + G + + +AK + D++K
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 789
Query: 647 LD 648
D
Sbjct: 790 TD 791
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/224 (24%), Positives = 101/224 (45%), Gaps = 14/224 (6%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
+ +++ +K G + + + I ++ T L A +G +VV+ L+ GANVNA
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+TPL+ A ++V+ L+E+GA + A+ + TPL A++ + V +L++
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 614 GAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPE 673
G K ++ A+ +A D R ++ L N P P K G TP +
Sbjct: 167 GTKGKVR----LPALHIAARNDDTRTAAVL---LQNDPNPDVLSK-TGFTPLHIAAHYEN 218
Query: 674 IKKEEELLSSIYGVPTTSEGK------KVQKGNVVHLNSLITSG 711
+ + LL+ V T + ++GNV+ + L+ G
Sbjct: 219 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/155 (24%), Positives = 70/155 (45%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
++K F+ +++ K G + + E + TPL A N+D+VK LL +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
+ ++ +TPLH A Q ++ L++ G +A S+ TPL+ A + + V
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
LL A L N+ G + + + + D++
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/119 (26%), Positives = 58/119 (48%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ G P+ K +P+ A ++D V+ LL+ A ++ TPLH A H G
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
+ ++L++ GA ++ ++N TPL+ A + + ++ LL GA G + + VA
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Score = 57.0 bits (136), Expect = 7e-08
Identities = 39/131 (29%), Positives = 62/131 (47%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
++G+L +G+ ++ + L A G++ +V LL K + T T
Sbjct: 21 RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNT 80
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
LH A AGQ ++V LV GA ++A S TPL A + L+ VK+LL+ GA +
Sbjct: 81 ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
Query: 621 NRKGHSAMDVA 631
G + + VA
Sbjct: 141 TEDGFTPLAVA 151
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/143 (30%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
FLRA + D L L G + N N + G L AS+EG V++V +L + +
Sbjct: 16 FLRAARSGN--LDKALDHLRNGVDINTCNQN-GLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ A H AA G ++++ L Y +V S G TPL+ AA + K++ +
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 273 RGCDLKWKNLDHKTPRAVAKEGG 295
G + D TP AVA + G
Sbjct: 133 NGANQNVATEDGFTPLAVALQQG 155
Score = 47.4 bits (111), Expect = 5e-05
Identities = 47/215 (21%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+K F+ + + + L +K E+G ++ TPL A G+ +VV L+ G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 549 A-----------------------------NVNATDNFLWTPLHFACHAGQQDIVELLVE 579
N + +TPLH A H ++ +LL+
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 580 SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRI 639
GA ++ N TPL+ A + V+ LLD GA+ + + + + + A RI
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 640 IDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEI 674
+++ LD+ P + + G +P + +G +
Sbjct: 288 SEIL---LDH-GAPIQAKTKNGLSPIHMAAQGDHL 318
Score = 36.6 bits (83), Expect = 0.091
Identities = 24/107 (22%), Positives = 49/107 (45%)
Query: 187 TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGL 246
T+ + A+R G ++ L G ++N + + + H A+K G ++ L +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 247 ISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKE 293
+ GNT LH AA+ G + + + G ++ ++ TP +A +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 94.4 bits (233), Expect = 4e-19
Identities = 83/299 (27%), Positives = 137/299 (45%), Gaps = 24/299 (8%)
Query: 38 ELINYTEPIN-----GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELG 92
EL+NY +N G + L++A+ N +++V FLL+ GA+ +V G TP A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 93 HELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRH-YRCALIALEHGADVNNSTYEG-K 150
HE A + +GK L + + R A + L++ + + + G
Sbjct: 156 HE-------NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 208
Query: 151 PIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGE 210
P+ + A ++ +V L +GA+ N G T L ASR G V +VR +L+RG +
Sbjct: 209 PLHIAA---HYENLNVAQLLLNRGASVN-FTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 211 VNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYI 270
+ D H AA+ G I ++L + + + NG +P+H AA G DC + +
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 271 AQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
Q ++ LDH TP VA G R A+ + +K A+P ++ N L +
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHH------RVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/352 (26%), Positives = 140/352 (39%), Gaps = 70/352 (19%)
Query: 40 INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
+N+T P NG++ LH+AS ++ MV LLD GA + + + TP AA GH EI
Sbjct: 232 VNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 100 L--------AKAKADMTIVDNEGKGVLFYCILPTKR-----------------------H 128
L AK K ++ + +G C+ + H
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 129 YRCALIALEHGADVNNSTYEGKPIFLRACEDAH---------------DVKDVCLT---- 169
+R A + L+ GA N+ G AC+ H V + LT
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
Query: 170 ------------FLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
L++GA+PN N T L A+R G E+ + +L+ +VNA D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 469
Query: 218 RHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
H AA+ G +++KLL N + L + G+TPLH AA G + + ++
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 278 KWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
TP VA + G ++R AE + + A P A N L L +
Sbjct: 530 ACMTKKGFTPLHVAAKYG------KVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 79.7 bits (195), Expect = 9e-15
Identities = 72/249 (28%), Positives = 108/249 (43%), Gaps = 5/249 (2%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+GL+ LH+AS + +V LL GA P+V + TP AA GH + L + KA
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ + + L +C H + LE+ A+ N +T G A + H +
Sbjct: 463 VNAKAKDDQTPL-HCAARIG-HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH--VET 518
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L LEK A+ A + G T L A++ G V + +LER NA + H A
Sbjct: 519 VLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
DI+KLL G + NG TPLH AA + + + Q G +++ T
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637
Query: 287 PRAVAKEGG 295
P +A + G
Sbjct: 638 PLHLAAQEG 646
Score = 76.3 bits (186), Expect = 1e-13
Identities = 47/158 (29%), Positives = 82/158 (51%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+E + +++ + G L +K + G ++ + +TPL A +G+ +V K+LL+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A VNA TPLH A G ++V+LL+E+ A + A+ TPL+ A ++TV
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 520
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
LL+ A +KG + + VA Y R+ +L+ E+
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558
Score = 72.4 bits (176), Expect = 2e-12
Identities = 63/250 (25%), Positives = 106/250 (42%), Gaps = 7/250 (2%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGH-ELSMEILAKAKAD 106
G + LH+A+ + + LL+ AHP+ + G TP A + ++ +L + +
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ N G I + A L++G N + +G A ++ H ++
Sbjct: 596 HSPAWN---GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH--AEM 650
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L K AN N N S G T L ++EG V + +++ G V+A + H A+
Sbjct: 651 VALLLSKQANGNLGNKS-GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G ++K L + DV + G +PLH AA G D + + G + D T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 287 PRAVAKEGGF 296
P A+AK G+
Sbjct: 770 PLAIAKRLGY 779
Score = 71.6 bits (174), Expect = 3e-12
Identities = 42/154 (27%), Positives = 79/154 (51%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
F+ ++I K + ++ ++G +D TPL A G++ +VK LL++GA+ N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
++ + TPLH A AG ++ + L+++ A ++A + ++ TPL+ A + VK LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
A L GH+ + +A + + EK
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/204 (26%), Positives = 92/204 (45%), Gaps = 4/204 (1%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+ F+ ++I +L + G V+ TPL A GN+ +V+ LL++G
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A + TPLH A G I E+L++ GA I A + N +P++ A + LD V+
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILK 668
LL A+ + + VA +R+ ++ LD KP ++ L G TP +
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL---LDKGAKP-NSRALNGFTPLHIA 378
Query: 669 TEGPEIKKEEELLSSIYGVPTTSE 692
+ ++ E LL + + +E
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTE 402
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/140 (36%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G+ V K LL+KGA N+ +TPLH AC ++ELL+++GA IDA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ + TPL+ A L VK LL GA + N K + + +A A A + ++ K
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA-ARAGH--TEVAKYL 456
Query: 647 LDNLPKPAENQKLKGKTPPI 666
L N K N K K P+
Sbjct: 457 LQN--KAKVNAKAKDDQTPL 474
Score = 64.3 bits (155), Expect = 4e-10
Identities = 57/208 (27%), Positives = 90/208 (43%), Gaps = 26/208 (12%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++++ + G + + G+ VD TPL A GNI +VKFLL+ A+VNA
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPL---NRAIESCRLDTVKYLLD 612
++PLH A G DIV LL+++GA + S + +TPL R D +K + D
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
Query: 613 ------------------IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPA 654
+ + +G + D R +D KE LD +PK
Sbjct: 792 ETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPK-- 849
Query: 655 ENQKLKGKTPPILKTEGPE---IKKEEE 679
+Q ++ P + PE I+ EE+
Sbjct: 850 LDQVVESPAIPRIPCAMPETVVIRSEEQ 877
Score = 63.5 bits (153), Expect = 7e-10
Identities = 48/160 (30%), Positives = 73/160 (45%), Gaps = 11/160 (6%)
Query: 44 EPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKA 103
E + G++ LHLA+ +MV+ LL A+ ++ ++ G TP A+ GH ++L K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 104 KADMTIVDNEGKGVLFYCILPTKRHY---RCALIALEHGADVNNSTYEGKPIFLRACEDA 160
+ G Y L HY + L+H ADVN T G +A +
Sbjct: 691 GVMVDATTRMG-----YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745
Query: 161 HDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEI 200
H D+ L+ GA+PN + SS G T L A R G + +
Sbjct: 746 H--TDIVTLLLKNGASPNEV-SSDGTTPLAIAKRLGYISV 782
Score = 61.6 bits (148), Expect = 3e-09
Identities = 36/123 (29%), Positives = 61/123 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL AC ++ V++ LL+ GA+++A TPLH A G IV+ L++ GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+++ TPL+ A + + KYLL AK + + + + A ++ L+ E
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 647 LDN 649
N
Sbjct: 493 NAN 495
Score = 60.8 bits (146), Expect = 5e-09
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 8/214 (3%)
Query: 491 KVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGAN 550
KV + +++ +AG K ++ V+ K +TPL A G+ ++VK LLE AN
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 551 VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610
N TPLH A G + V L+E A + TPL+ A + ++ + L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Query: 611 LDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTE 670
L+ A + G + + VA + + I+ L+ + + PA N G TP + +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN----GYTPLHIAAK 611
Query: 671 GPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHL 704
+++ LL YG +E VQ +HL
Sbjct: 612 QNQVEVARSLLQ--YGGSANAE--SVQGVTPLHL 641
Score = 60.8 bits (146), Expect = 5e-09
Identities = 38/123 (30%), Positives = 60/123 (48%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G + V + LLE+ A+ NA TPLH A H DIV+LL+ G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ N TPL+ A + +++ + LL G E+ +G + + +A ++ L+ K
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 647 LDN 649
N
Sbjct: 658 QAN 660
Score = 60.8 bits (146), Expect = 5e-09
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 4/172 (2%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
++ ++I K + + + G + + TPL A G+ ++V LL K AN N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
+ TPLH G + ++L++ G ++DA + TPL+ A + VK+LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
A + + G+S + A I+ L+ L N P E G TP
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPNEVSS-DGTTP 770
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/223 (25%), Positives = 93/223 (41%), Gaps = 10/223 (4%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++ + G +K E+ ++ TPL A G+++ V LLEK A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPLH A G+ + ELL+E A +AA N TPL+ A+ LD VK LL G
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 616 KFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
G++ + +A A +++ + L A + ++G TP L + +
Sbjct: 594 SPHSPAWNGYTPLHIA---AKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDI 718
LLS + G K + L+ + G+ D+
Sbjct: 650 MVALLLSK------QANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/122 (29%), Positives = 60/122 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL G++ V L++ G V+AT +TPLH A H G +V+ L++ A ++A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ +PL++A + D V LL GA + G + + +AK + D++K
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 789
Query: 647 LD 648
D
Sbjct: 790 TD 791
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/224 (24%), Positives = 101/224 (45%), Gaps = 14/224 (6%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
+ +++ +K G + + + I ++ T L A +G +VV+ L+ GANVNA
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+TPL+ A ++V+ L+E+GA + A+ + TPL A++ + V +L++
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 614 GAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPE 673
G K ++ A+ +A D R ++ L N P P K G TP +
Sbjct: 167 GTKGKVR----LPALHIAARNDDTRTAAVL---LQNDPNPDVLSK-TGFTPLHIAAHYEN 218
Query: 674 IKKEEELLSSIYGVPTTSEGK------KVQKGNVVHLNSLITSG 711
+ + LL+ V T + ++GNV+ + L+ G
Sbjct: 219 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/155 (24%), Positives = 70/155 (45%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
++K F+ +++ K G + + E + TPL A N+D+VK LL +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
+ ++ +TPLH A Q ++ L++ G +A S+ TPL+ A + + V
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
LL A L N+ G + + + + D++
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/119 (26%), Positives = 58/119 (48%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ G P+ K +P+ A ++D V+ LL+ A ++ TPLH A H G
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
+ ++L++ GA ++ ++N TPL+ A + + ++ LL GA G + + VA
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Score = 57.0 bits (136), Expect = 7e-08
Identities = 39/131 (29%), Positives = 62/131 (47%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
++G+L +G+ ++ + L A G++ +V LL K + T T
Sbjct: 21 RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNT 80
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
LH A AGQ ++V LV GA ++A S TPL A + L+ VK+LL+ GA +
Sbjct: 81 ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
Query: 621 NRKGHSAMDVA 631
G + + VA
Sbjct: 141 TEDGFTPLAVA 151
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/143 (30%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
FLRA + D L L G + N N + G L AS+EG V++V +L + +
Sbjct: 16 FLRAARSGN--LDKALDHLRNGVDINTCNQN-GLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ A H AA G ++++ L Y +V S G TPL+ AA + K++ +
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 273 RGCDLKWKNLDHKTPRAVAKEGG 295
G + D TP AVA + G
Sbjct: 133 NGANQNVATEDGFTPLAVALQQG 155
Score = 47.4 bits (111), Expect = 5e-05
Identities = 47/215 (21%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+K F+ + + + L +K E+G ++ TPL A G+ +VV L+ G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 549 A-----------------------------NVNATDNFLWTPLHFACHAGQQDIVELLVE 579
N + +TPLH A H ++ +LL+
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 580 SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRI 639
GA ++ N TPL+ A + V+ LLD GA+ + + + + + A RI
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 640 IDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEI 674
+++ LD+ P + + G +P + +G +
Sbjct: 288 SEIL---LDH-GAPIQAKTKNGLSPIHMAAQGDHL 318
Score = 36.6 bits (83), Expect = 0.091
Identities = 24/107 (22%), Positives = 49/107 (45%)
Query: 187 TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGL 246
T+ + A+R G ++ L G ++N + + + H A+K G ++ L +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 247 ISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKE 293
+ GNT LH AA+ G + + + G ++ ++ TP +A +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 94.4 bits (233), Expect = 4e-19
Identities = 83/299 (27%), Positives = 137/299 (45%), Gaps = 24/299 (8%)
Query: 38 ELINYTEPIN-----GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELG 92
EL+NY +N G + L++A+ N +++V FLL+ GA+ +V G TP A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 93 HELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRH-YRCALIALEHGADVNNSTYEG-K 150
HE A + +GK L + + R A + L++ + + + G
Sbjct: 156 HE-------NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 208
Query: 151 PIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGE 210
P+ + A ++ +V L +GA+ N G T L ASR G V +VR +L+RG +
Sbjct: 209 PLHIAA---HYENLNVAQLLLNRGASVN-FTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 211 VNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYI 270
+ D H AA+ G I ++L + + + NG +P+H AA G DC + +
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 271 AQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
Q ++ LDH TP VA G R A+ + +K A+P ++ N L +
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHH------RVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/352 (26%), Positives = 140/352 (39%), Gaps = 70/352 (19%)
Query: 40 INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
+N+T P NG++ LH+AS ++ MV LLD GA + + + TP AA GH EI
Sbjct: 232 VNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 100 L--------AKAKADMTIVDNEGKGVLFYCILPTKR-----------------------H 128
L AK K ++ + +G C+ + H
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 129 YRCALIALEHGADVNNSTYEGKPIFLRACEDAH---------------DVKDVCLT---- 169
+R A + L+ GA N+ G AC+ H V + LT
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
Query: 170 ------------FLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
L++GA+PN N T L A+R G E+ + +L+ +VNA D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 469
Query: 218 RHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
H AA+ G +++KLL N + L + G+TPLH AA G + + ++
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 278 KWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
TP VA + G ++R AE + + A P A N L L +
Sbjct: 530 ACMTKKGFTPLHVAAKYG------KVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 79.7 bits (195), Expect = 9e-15
Identities = 72/249 (28%), Positives = 108/249 (43%), Gaps = 5/249 (2%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+GL+ LH+AS + +V LL GA P+V + TP AA GH + L + KA
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ + + L +C H + LE+ A+ N +T G A + H +
Sbjct: 463 VNAKAKDDQTPL-HCAARIG-HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH--VET 518
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L LEK A+ A + G T L A++ G V + +LER NA + H A
Sbjct: 519 VLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
DI+KLL G + NG TPLH AA + + + Q G +++ T
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637
Query: 287 PRAVAKEGG 295
P +A + G
Sbjct: 638 PLHLAAQEG 646
Score = 76.3 bits (186), Expect = 1e-13
Identities = 47/158 (29%), Positives = 82/158 (51%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+E + +++ + G L +K + G ++ + +TPL A +G+ +V K+LL+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A VNA TPLH A G ++V+LL+E+ A + A+ TPL+ A ++TV
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 520
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
LL+ A +KG + + VA Y R+ +L+ E+
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558
Score = 72.4 bits (176), Expect = 2e-12
Identities = 63/250 (25%), Positives = 106/250 (42%), Gaps = 7/250 (2%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGH-ELSMEILAKAKAD 106
G + LH+A+ + + LL+ AHP+ + G TP A + ++ +L + +
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ N G I + A L++G N + +G A ++ H ++
Sbjct: 596 HSPAWN---GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH--AEM 650
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L K AN N N S G T L ++EG V + +++ G V+A + H A+
Sbjct: 651 VALLLSKQANGNLGNKS-GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G ++K L + DV + G +PLH AA G D + + G + D T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 287 PRAVAKEGGF 296
P A+AK G+
Sbjct: 770 PLAIAKRLGY 779
Score = 71.6 bits (174), Expect = 3e-12
Identities = 42/154 (27%), Positives = 79/154 (51%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
F+ ++I K + ++ ++G +D TPL A G++ +VK LL++GA+ N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
++ + TPLH A AG ++ + L+++ A ++A + ++ TPL+ A + VK LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
A L GH+ + +A + + EK
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/204 (26%), Positives = 92/204 (45%), Gaps = 4/204 (1%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+ F+ ++I +L + G V+ TPL A GN+ +V+ LL++G
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A + TPLH A G I E+L++ GA I A + N +P++ A + LD V+
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILK 668
LL A+ + + VA +R+ ++ LD KP ++ L G TP +
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL---LDKGAKP-NSRALNGFTPLHIA 378
Query: 669 TEGPEIKKEEELLSSIYGVPTTSE 692
+ ++ E LL + + +E
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTE 402
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/140 (36%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G+ V K LL+KGA N+ +TPLH AC ++ELL+++GA IDA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ + TPL+ A L VK LL GA + N K + + +A A A + ++ K
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA-ARAGH--TEVAKYL 456
Query: 647 LDNLPKPAENQKLKGKTPPI 666
L N K N K K P+
Sbjct: 457 LQN--KAKVNAKAKDDQTPL 474
Score = 64.3 bits (155), Expect = 4e-10
Identities = 57/208 (27%), Positives = 90/208 (43%), Gaps = 26/208 (12%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++++ + G + + G+ VD TPL A GNI +VKFLL+ A+VNA
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPL---NRAIESCRLDTVKYLLD 612
++PLH A G DIV LL+++GA + S + +TPL R D +K + D
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
Query: 613 ------------------IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPA 654
+ + +G + D R +D KE LD +PK
Sbjct: 792 ETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPK-- 849
Query: 655 ENQKLKGKTPPILKTEGPE---IKKEEE 679
+Q ++ P + PE I+ EE+
Sbjct: 850 LDQVVESPAIPRIPCAMPETVVIRSEEQ 877
Score = 63.5 bits (153), Expect = 7e-10
Identities = 48/160 (30%), Positives = 73/160 (45%), Gaps = 11/160 (6%)
Query: 44 EPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKA 103
E + G++ LHLA+ +MV+ LL A+ ++ ++ G TP A+ GH ++L K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 104 KADMTIVDNEGKGVLFYCILPTKRHY---RCALIALEHGADVNNSTYEGKPIFLRACEDA 160
+ G Y L HY + L+H ADVN T G +A +
Sbjct: 691 GVMVDATTRMG-----YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745
Query: 161 HDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEI 200
H D+ L+ GA+PN + SS G T L A R G + +
Sbjct: 746 H--TDIVTLLLKNGASPNEV-SSDGTTPLAIAKRLGYISV 782
Score = 61.6 bits (148), Expect = 3e-09
Identities = 36/123 (29%), Positives = 61/123 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL AC ++ V++ LL+ GA+++A TPLH A G IV+ L++ GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+++ TPL+ A + + KYLL AK + + + + A ++ L+ E
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 647 LDN 649
N
Sbjct: 493 NAN 495
Score = 60.8 bits (146), Expect = 5e-09
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 8/214 (3%)
Query: 491 KVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGAN 550
KV + +++ +AG K ++ V+ K +TPL A G+ ++VK LLE AN
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 551 VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610
N TPLH A G + V L+E A + TPL+ A + ++ + L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Query: 611 LDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTE 670
L+ A + G + + VA + + I+ L+ + + PA N G TP + +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN----GYTPLHIAAK 611
Query: 671 GPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHL 704
+++ LL YG +E VQ +HL
Sbjct: 612 QNQVEVARSLLQ--YGGSANAE--SVQGVTPLHL 641
Score = 60.8 bits (146), Expect = 5e-09
Identities = 38/123 (30%), Positives = 60/123 (48%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G + V + LLE+ A+ NA TPLH A H DIV+LL+ G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ N TPL+ A + +++ + LL G E+ +G + + +A ++ L+ K
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 647 LDN 649
N
Sbjct: 658 QAN 660
Score = 60.8 bits (146), Expect = 5e-09
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 4/172 (2%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
++ ++I K + + + G + + TPL A G+ ++V LL K AN N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
+ TPLH G + ++L++ G ++DA + TPL+ A + VK+LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
A + + G+S + A I+ L+ L N P E G TP
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPNEVSS-DGTTP 770
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/223 (25%), Positives = 93/223 (41%), Gaps = 10/223 (4%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++ + G +K E+ ++ TPL A G+++ V LLEK A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPLH A G+ + ELL+E A +AA N TPL+ A+ LD VK LL G
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 616 KFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
G++ + +A A +++ + L A + ++G TP L + +
Sbjct: 594 SPHSPAWNGYTPLHIA---AKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDI 718
LLS + G K + L+ + G+ D+
Sbjct: 650 MVALLLSK------QANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/122 (29%), Positives = 60/122 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL G++ V L++ G V+AT +TPLH A H G +V+ L++ A ++A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ +PL++A + D V LL GA + G + + +AK + D++K
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 789
Query: 647 LD 648
D
Sbjct: 790 TD 791
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/224 (24%), Positives = 101/224 (45%), Gaps = 14/224 (6%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
+ +++ +K G + + + I ++ T L A +G +VV+ L+ GANVNA
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+TPL+ A ++V+ L+E+GA + A+ + TPL A++ + V +L++
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 614 GAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPE 673
G K ++ A+ +A D R ++ L N P P K G TP +
Sbjct: 167 GTKGKVR----LPALHIAARNDDTRTAAVL---LQNDPNPDVLSK-TGFTPLHIAAHYEN 218
Query: 674 IKKEEELLSSIYGVPTTSEGK------KVQKGNVVHLNSLITSG 711
+ + LL+ V T + ++GNV+ + L+ G
Sbjct: 219 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/155 (24%), Positives = 70/155 (45%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
++K F+ +++ K G + + E + TPL A N+D+VK LL +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
+ ++ +TPLH A Q ++ L++ G +A S+ TPL+ A + + V
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
LL A L N+ G + + + + D++
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/119 (26%), Positives = 58/119 (48%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ G P+ K +P+ A ++D V+ LL+ A ++ TPLH A H G
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
+ ++L++ GA ++ ++N TPL+ A + + ++ LL GA G + + VA
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Score = 57.0 bits (136), Expect = 7e-08
Identities = 39/131 (29%), Positives = 62/131 (47%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
++G+L +G+ ++ + L A G++ +V LL K + T T
Sbjct: 21 RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNT 80
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
LH A AGQ ++V LV GA ++A S TPL A + L+ VK+LL+ GA +
Sbjct: 81 ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
Query: 621 NRKGHSAMDVA 631
G + + VA
Sbjct: 141 TEDGFTPLAVA 151
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/143 (30%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
FLRA + D L L G + N N + G L AS+EG V++V +L + +
Sbjct: 16 FLRAARSGN--LDKALDHLRNGVDINTCNQN-GLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ A H AA G ++++ L Y +V S G TPL+ AA + K++ +
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 273 RGCDLKWKNLDHKTPRAVAKEGG 295
G + D TP AVA + G
Sbjct: 133 NGANQNVATEDGFTPLAVALQQG 155
Score = 47.4 bits (111), Expect = 5e-05
Identities = 47/215 (21%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+K F+ + + + L +K E+G ++ TPL A G+ +VV L+ G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 549 A-----------------------------NVNATDNFLWTPLHFACHAGQQDIVELLVE 579
N + +TPLH A H ++ +LL+
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 580 SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRI 639
GA ++ N TPL+ A + V+ LLD GA+ + + + + + A RI
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 640 IDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEI 674
+++ LD+ P + + G +P + +G +
Sbjct: 288 SEIL---LDH-GAPIQAKTKNGLSPIHMAAQGDHL 318
Score = 36.6 bits (83), Expect = 0.091
Identities = 24/107 (22%), Positives = 49/107 (45%)
Query: 187 TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGL 246
T+ + A+R G ++ L G ++N + + + H A+K G ++ L +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 247 ISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKE 293
+ GNT LH AA+ G + + + G ++ ++ TP +A +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 94.4 bits (233), Expect = 4e-19
Identities = 83/299 (27%), Positives = 137/299 (45%), Gaps = 24/299 (8%)
Query: 38 ELINYTEPIN-----GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELG 92
EL+NY +N G + L++A+ N +++V FLL+ GA+ +V G TP A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 93 HELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRH-YRCALIALEHGADVNNSTYEG-K 150
HE A + +GK L + + R A + L++ + + + G
Sbjct: 156 HE-------NVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFT 208
Query: 151 PIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGE 210
P+ + A ++ +V L +GA+ N G T L ASR G V +VR +L+RG +
Sbjct: 209 PLHIAA---HYENLNVAQLLLNRGASVN-FTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 211 VNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYI 270
+ D H AA+ G I ++L + + + NG +P+H AA G DC + +
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 271 AQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
Q ++ LDH TP VA G R A+ + +K A+P ++ N L +
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHH------RVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/352 (26%), Positives = 140/352 (39%), Gaps = 70/352 (19%)
Query: 40 INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
+N+T P NG++ LH+AS ++ MV LLD GA + + + TP AA GH EI
Sbjct: 232 VNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEI 290
Query: 100 L--------AKAKADMTIVDNEGKGVLFYCILPTKR-----------------------H 128
L AK K ++ + +G C+ + H
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 129 YRCALIALEHGADVNNSTYEGKPIFLRACEDAH---------------DVKDVCLT---- 169
+R A + L+ GA N+ G AC+ H V + LT
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
Query: 170 ------------FLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
L++GA+PN N T L A+R G E+ + +L+ +VNA D
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKD 469
Query: 218 RHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
H AA+ G +++KLL N + L + G+TPLH AA G + + ++
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 278 KWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
TP VA + G ++R AE + + A P A N L L +
Sbjct: 530 ACMTKKGFTPLHVAAKYG------KVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 79.7 bits (195), Expect = 9e-15
Identities = 72/249 (28%), Positives = 108/249 (43%), Gaps = 5/249 (2%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+GL+ LH+AS + +V LL GA P+V + TP AA GH + L + KA
Sbjct: 403 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 462
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ + + L +C H + LE+ A+ N +T G A + H +
Sbjct: 463 VNAKAKDDQTPL-HCAARIG-HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH--VET 518
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L LEK A+ A + G T L A++ G V + +LER NA + H A
Sbjct: 519 VLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
DI+KLL G + NG TPLH AA + + + Q G +++ T
Sbjct: 578 HHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVT 637
Query: 287 PRAVAKEGG 295
P +A + G
Sbjct: 638 PLHLAAQEG 646
Score = 76.3 bits (186), Expect = 1e-13
Identities = 47/158 (29%), Positives = 82/158 (51%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
+E + +++ + G L +K + G ++ + +TPL A +G+ +V K+LL+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A VNA TPLH A G ++V+LL+E+ A + A+ TPL+ A ++TV
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 520
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
LL+ A +KG + + VA Y R+ +L+ E+
Sbjct: 521 ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558
Score = 72.4 bits (176), Expect = 2e-12
Identities = 63/250 (25%), Positives = 106/250 (42%), Gaps = 7/250 (2%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGH-ELSMEILAKAKAD 106
G + LH+A+ + + LL+ AHP+ + G TP A + ++ +L + +
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+ N G I + A L++G N + +G A ++ H ++
Sbjct: 596 HSPAWN---GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH--AEM 650
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L K AN N N S G T L ++EG V + +++ G V+A + H A+
Sbjct: 651 VALLLSKQANGNLGNKS-GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G ++K L + DV + G +PLH AA G D + + G + D T
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Query: 287 PRAVAKEGGF 296
P A+AK G+
Sbjct: 770 PLAIAKRLGY 779
Score = 71.6 bits (174), Expect = 3e-12
Identities = 42/154 (27%), Positives = 79/154 (51%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
F+ ++I K + ++ ++G +D TPL A G++ +VK LL++GA+ N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
++ + TPLH A AG ++ + L+++ A ++A + ++ TPL+ A + VK LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
A L GH+ + +A + + EK
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525
Score = 66.2 bits (160), Expect = 1e-10
Identities = 54/204 (26%), Positives = 92/204 (45%), Gaps = 4/204 (1%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+ F+ ++I +L + G V+ TPL A GN+ +V+ LL++G
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A + TPLH A G I E+L++ GA I A + N +P++ A + LD V+
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILK 668
LL A+ + + VA +R+ ++ LD KP ++ L G TP +
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL---LDKGAKP-NSRALNGFTPLHIA 378
Query: 669 TEGPEIKKEEELLSSIYGVPTTSE 692
+ ++ E LL + + +E
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTE 402
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/140 (36%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G+ V K LL+KGA N+ +TPLH AC ++ELL+++GA IDA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ + TPL+ A L VK LL GA + N K + + +A A A + ++ K
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA-ARAGH--TEVAKYL 456
Query: 647 LDNLPKPAENQKLKGKTPPI 666
L N K N K K P+
Sbjct: 457 LQN--KAKVNAKAKDDQTPL 474
Score = 64.3 bits (155), Expect = 4e-10
Identities = 57/208 (27%), Positives = 90/208 (43%), Gaps = 26/208 (12%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++++ + G + + G+ VD TPL A GNI +VKFLL+ A+VNA
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPL---NRAIESCRLDTVKYLLD 612
++PLH A G DIV LL+++GA + S + +TPL R D +K + D
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 791
Query: 613 ------------------IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPA 654
+ + +G + D R +D KE LD +PK
Sbjct: 792 ETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPK-- 849
Query: 655 ENQKLKGKTPPILKTEGPE---IKKEEE 679
+Q ++ P + PE I+ EE+
Sbjct: 850 LDQVVESPAIPRIPCAMPETVVIRSEEQ 877
Score = 63.5 bits (153), Expect = 7e-10
Identities = 48/160 (30%), Positives = 73/160 (45%), Gaps = 11/160 (6%)
Query: 44 EPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKA 103
E + G++ LHLA+ +MV+ LL A+ ++ ++ G TP A+ GH ++L K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 104 KADMTIVDNEGKGVLFYCILPTKRHY---RCALIALEHGADVNNSTYEGKPIFLRACEDA 160
+ G Y L HY + L+H ADVN T G +A +
Sbjct: 691 GVMVDATTRMG-----YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG 745
Query: 161 HDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEI 200
H D+ L+ GA+PN + SS G T L A R G + +
Sbjct: 746 H--TDIVTLLLKNGASPNEV-SSDGTTPLAIAKRLGYISV 782
Score = 61.6 bits (148), Expect = 3e-09
Identities = 36/123 (29%), Positives = 61/123 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL AC ++ V++ LL+ GA+++A TPLH A G IV+ L++ GA +
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+++ TPL+ A + + KYLL AK + + + + A ++ L+ E
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 647 LDN 649
N
Sbjct: 493 NAN 495
Score = 60.8 bits (146), Expect = 5e-09
Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 8/214 (3%)
Query: 491 KVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGAN 550
KV + +++ +AG K ++ V+ K +TPL A G+ ++VK LLE AN
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 551 VNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYL 610
N TPLH A G + V L+E A + TPL+ A + ++ + L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Query: 611 LDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTE 670
L+ A + G + + VA + + I+ L+ + + PA N G TP + +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN----GYTPLHIAAK 611
Query: 671 GPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHL 704
+++ LL YG +E VQ +HL
Sbjct: 612 QNQVEVARSLLQ--YGGSANAE--SVQGVTPLHL 641
Score = 60.8 bits (146), Expect = 5e-09
Identities = 38/123 (30%), Positives = 60/123 (48%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G + V + LLE+ A+ NA TPLH A H DIV+LL+ G +
Sbjct: 538 TPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ N TPL+ A + +++ + LL G E+ +G + + +A ++ L+ K
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 647 LDN 649
N
Sbjct: 658 QAN 660
Score = 60.8 bits (146), Expect = 5e-09
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 4/172 (2%)
Query: 493 FSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVN 552
++ ++I K + + + G + + TPL A G+ ++V LL K AN N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 553 ATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLD 612
+ TPLH G + ++L++ G ++DA + TPL+ A + VK+LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 613 IGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
A + + G+S + A I+ L+ L N P E G TP
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLL---LKNGASPNEVSS-DGTTP 770
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/223 (25%), Positives = 93/223 (41%), Gaps = 10/223 (4%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
++ + G +K E+ ++ TPL A G+++ V LLEK A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+TPLH A G+ + ELL+E A +AA N TPL+ A+ LD VK LL G
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 616 KFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
G++ + +A A +++ + L A + ++G TP L + +
Sbjct: 594 SPHSPAWNGYTPLHIA---AKQNQVEVARSLL-QYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKVDI 718
LLS + G K + L+ + G+ D+
Sbjct: 650 MVALLLSK------QANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/122 (29%), Positives = 60/122 (49%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL G++ V L++ G V+AT +TPLH A H G +V+ L++ A ++A
Sbjct: 670 TPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK 646
+ +PL++A + D V LL GA + G + + +AK + D++K
Sbjct: 730 KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVV 789
Query: 647 LD 648
D
Sbjct: 790 TD 791
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/224 (24%), Positives = 101/224 (45%), Gaps = 14/224 (6%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
+ +++ +K G + + + I ++ T L A +G +VV+ L+ GANVNA
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+TPL+ A ++V+ L+E+GA + A+ + TPL A++ + V +L++
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Query: 614 GAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPE 673
G K ++ A+ +A D R ++ L N P P K G TP +
Sbjct: 167 GTKGKVR----LPALHIAARNDDTRTAAVL---LQNDPNPDVLSK-TGFTPLHIAAHYEN 218
Query: 674 IKKEEELLSSIYGVPTTSEGK------KVQKGNVVHLNSLITSG 711
+ + LL+ V T + ++GNV+ + L+ G
Sbjct: 219 LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/155 (24%), Positives = 70/155 (45%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
++K F+ +++ K G + + E + TPL A N+D+VK LL +G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
+ ++ +TPLH A Q ++ L++ G +A S+ TPL+ A + + V
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVA 652
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
LL A L N+ G + + + + D++
Sbjct: 653 LLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/119 (26%), Positives = 58/119 (48%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ G P+ K +P+ A ++D V+ LL+ A ++ TPLH A H G
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
+ ++L++ GA ++ ++N TPL+ A + + ++ LL GA G + + VA
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Score = 57.0 bits (136), Expect = 7e-08
Identities = 39/131 (29%), Positives = 62/131 (47%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
++G+L +G+ ++ + L A G++ +V LL K + T T
Sbjct: 21 RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNT 80
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
LH A AGQ ++V LV GA ++A S TPL A + L+ VK+LL+ GA +
Sbjct: 81 ALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 140
Query: 621 NRKGHSAMDVA 631
G + + VA
Sbjct: 141 TEDGFTPLAVA 151
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/143 (30%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 153 FLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVN 212
FLRA + D L L G + N N + G L AS+EG V++V +L + +
Sbjct: 16 FLRAARSGN--LDKALDHLRNGVDINTCNQN-GLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ A H AA G ++++ L Y +V S G TPL+ AA + K++ +
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 273 RGCDLKWKNLDHKTPRAVAKEGG 295
G + D TP AVA + G
Sbjct: 133 NGANQNVATEDGFTPLAVALQQG 155
Score = 47.4 bits (111), Expect = 5e-05
Identities = 47/215 (21%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
S+K F+ + + + L +K E+G ++ TPL A G+ +VV L+ G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 549 A-----------------------------NVNATDNFLWTPLHFACHAGQQDIVELLVE 579
N + +TPLH A H ++ +LL+
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 580 SGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRI 639
GA ++ N TPL+ A + V+ LLD GA+ + + + + + A RI
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 640 IDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEI 674
+++ LD+ P + + G +P + +G +
Sbjct: 288 SEIL---LDH-GAPIQAKTKNGLSPIHMAAQGDHL 318
Score = 36.6 bits (83), Expect = 0.091
Identities = 24/107 (22%), Positives = 49/107 (45%)
Query: 187 TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGL 246
T+ + A+R G ++ L G ++N + + + H A+K G ++ L +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 247 ISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKE 293
+ GNT LH AA+ G + + + G ++ ++ TP +A +
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 92.8 bits (229), Expect = 1e-18
Identities = 70/250 (28%), Positives = 109/250 (43%), Gaps = 7/250 (2%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+G L +A+ +I ++ L+ G+ DVQD+ G AA GH +++ L++ K
Sbjct: 378 HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCP 437
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVN-NSTYEGKPIFLRACEDAHDVKD 165
+ + D G+ L + H A + G++ N E P+ C H
Sbjct: 438 LDVKDKSGEMALH--VAARYGHADVAQLLCSFGSNPNIQDKEEETPLH---CAAWHGYYS 492
Query: 166 VCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFA 225
V E G N N I + G T L+ AS G +IV + E G ++NA D D H A H A
Sbjct: 493 VAKALCEAGCNVN-IKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551
Query: 226 AKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
+ +++K L + V +GNTPLH A G + + C+L N +
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGR 611
Query: 286 TPRAVAKEGG 295
TP +A G
Sbjct: 612 TPLHLAANNG 621
Score = 68.9 bits (167), Expect = 2e-11
Identities = 40/136 (29%), Positives = 72/136 (52%), Gaps = 3/136 (2%)
Query: 509 KKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHA 568
K E+G V++K+ +TPL+TA A G D+V+ L E GA++NA D LH A
Sbjct: 495 KALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRR 554
Query: 569 GQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAM 628
Q ++++ L+ G +D + +TPL+ A + + V L + + N+ G + +
Sbjct: 555 CQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPL 614
Query: 629 DVAKAYADYRIIDLIK 644
+A A+ I+D+++
Sbjct: 615 HLA---ANNGILDVVR 627
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/147 (32%), Positives = 72/147 (48%), Gaps = 2/147 (1%)
Query: 504 DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLH 563
D+A L +F S +++D +TPL A G V K L E G NVN + TPL
Sbjct: 459 DVAQLLCSFGSN--PNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLL 516
Query: 564 FACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRK 623
A G DIVE L E GA ++A + L+ A+ C+++ +K LL G ++R
Sbjct: 517 TASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH 576
Query: 624 GHSAMDVAKAYADYRIIDLIKEKLDNL 650
G++ + VA + I+ + E NL
Sbjct: 577 GNTPLHVACKDGNMPIVVALCEANCNL 603
Score = 62.4 bits (150), Expect = 2e-09
Identities = 46/156 (29%), Positives = 71/156 (45%), Gaps = 1/156 (0%)
Query: 486 IDDSEKVFSN-INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFL 544
ID +K SN + + G + +LK E+ P+D+KD + L A G+ DV + L
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464
Query: 545 LEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRL 604
G+N N D TPLH A G + + L E+G ++ + TPL A
Sbjct: 465 CSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYH 524
Query: 605 DTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRII 640
D V+ L + GA ++ GH A+ +A +I
Sbjct: 525 DIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560
Score = 60.1 bits (144), Expect = 8e-09
Identities = 43/158 (27%), Positives = 69/158 (43%), Gaps = 7/158 (4%)
Query: 141 DVNNSTYEGKPIFLRA--CEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVV 198
DVN G P L A C + L L K + + G A+ A+R G V
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQ-----ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHV 425
Query: 199 EIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYA 258
+ ++ + E ++ D A H AA+ G D+ +LL ++ + + TPLH A
Sbjct: 426 DTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485
Query: 259 AMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGF 296
A G+ K + + GC++ KN + +TP A G+
Sbjct: 486 AWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGY 523
Score = 57.8 bits (138), Expect = 4e-08
Identities = 33/129 (25%), Positives = 64/129 (49%), Gaps = 4/129 (3%)
Query: 496 INIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATD 555
+++ + + +K G VD +D + TPL AC GN+ +V L E N++ ++
Sbjct: 548 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 607
Query: 556 NFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ TPLH A + G D+V L GA ++A + + T A + R + +++ + A
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKT----AEDLARSEQHEHVAGLLA 663
Query: 616 KFQLENRKG 624
+ + + +G
Sbjct: 664 RLRKDTHRG 672
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/148 (24%), Positives = 64/148 (43%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
I G++ L+ + G +D++D + A G++D +KFL E ++ D
Sbjct: 385 IAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS 444
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
LH A G D+ +LL G+ + TPL+ A K L + G
Sbjct: 445 GEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNV 504
Query: 618 QLENRKGHSAMDVAKAYADYRIIDLIKE 645
++NR+G + + A A + I++ + E
Sbjct: 505 NIKNREGETPLLTASARGYHDIVECLAE 532
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/133 (25%), Positives = 63/133 (47%)
Query: 185 GRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDV 244
G L+ A+ G ++I++ +++RG ++ D +A ++AA+ G D LK L +
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438
Query: 245 GLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIR 304
+ +G LH AA G AD + + G + ++ + +TP A G+ + +K +
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALC 498
Query: 305 RAERIANKLARPG 317
A N R G
Sbjct: 499 EAGCNVNIKNREG 511
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 89.4 bits (220), Expect = 1e-17
Identities = 76/264 (28%), Positives = 112/264 (42%), Gaps = 7/264 (2%)
Query: 55 ASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEG 114
A + D D V L+ + QD TP AA LG +E+L + A + D++
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 115 KGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGK-PIFLRACEDAHDVKDVCLTFLEK 173
L + + L+H ADVN + P+ + A A + + L
Sbjct: 75 LTPLHRAVASCSEE--AVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL-- 130
Query: 174 GANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDI 233
+N N ++ GRTAL A+ G E+V+ +L RG +NAFD A H+AA G ++
Sbjct: 131 -SNVN-VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEV 188
Query: 234 LKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKE 293
+KLL ++ +V TPLH AA G KY+ G D+ N TP VA
Sbjct: 189 VKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACY 248
Query: 294 GGFKAASKEIRRAERIANKLARPG 317
G E+ I N+ G
Sbjct: 249 NGQDVVVNELIDCGAIVNQKNEKG 272
Score = 80.9 bits (198), Expect = 4e-15
Identities = 70/272 (25%), Positives = 117/272 (43%), Gaps = 8/272 (2%)
Query: 16 VLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPD 75
++Q + N D ++ L + E +N+ + + LH A+ D +++ L+ GA +
Sbjct: 12 LVQAIFNGDPDEVRAL--IFKKEDVNFQDN-EKRTPLHAAAYLGDAEIIELLILSGARVN 68
Query: 76 VQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIA 135
+D TP RA E ++++L K AD+ D + L I + +CA
Sbjct: 69 AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLH--IAAANKAVKCAEAL 126
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
+ ++VN S G+ A H ++ L +GAN NA + R A+ A+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHG--EMVKLLLSRGANINAFDKKD-RRAIHWAAYM 183
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G +E+V+ ++ G EV D + H AA G ++K L D+ + GNTPL
Sbjct: 184 GHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPL 243
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHKTP 287
H A G + G + KN TP
Sbjct: 244 HVACYNGQDVVVNELIDCGAIVNQKNEKGFTP 275
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/147 (33%), Positives = 76/147 (51%), Gaps = 4/147 (2%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V++ D +T L A SG+ ++VK LL +GAN+NA D +H+A + G ++V+LL
Sbjct: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192
Query: 578 VESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADY 637
V GA + + TPL+ A S + VKYLLD+G N G++ + V A Y
Sbjct: 193 VSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV----ACY 248
Query: 638 RIIDLIKEKLDNLPKPAENQKLKGKTP 664
D++ +L + + KG TP
Sbjct: 249 NGQDVVVNELIDCGAIVNQKNEKGFTP 275
Score = 72.0 bits (175), Expect = 2e-12
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 6/246 (2%)
Query: 51 ALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIV 110
A+H A+ I++V L+ GA +D+ TP AA G ++ L DM
Sbjct: 176 AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEP 235
Query: 111 DNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTF 170
+ G L + LI + GA VN +G A H +CL
Sbjct: 236 NAYGNTPLHVACYNGQDVVVNELI--DCGAIVNQKNEKGFTPLHFAAASTHGA--LCLEL 291
Query: 171 LE-KGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGG 229
L GA+ N + S G+T L + G + I++ G ++ D + + H AA+ G
Sbjct: 292 LVGNGADVN-MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 230 FFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRA 289
++ L D I+G PLH AA+ GF+DCC+ + G D+ + +T
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 290 VAKEGG 295
A GG
Sbjct: 411 AAAAGG 416
Score = 69.7 bits (169), Expect = 1e-11
Identities = 68/275 (24%), Positives = 112/275 (40%), Gaps = 15/275 (5%)
Query: 23 KDKKQIEKLTKLGYPELINYT---------EPINGLSALHLASVSNDIDMVSFLLDLGAH 73
KD++ I +G+ E++ + + LH A+ S I +V +LLDLG
Sbjct: 172 KDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVD 231
Query: 74 PDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCAL 133
+ + G TP A G ++ + L A + + +G L + T C
Sbjct: 232 MNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL-CLE 290
Query: 134 IALEHGADVNNSTYEGK-PIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEA 192
+ + +GADVN + +GK P+ + A H T ++ GA + G T L A
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTAL---HGRFSRSQTIIQSGAVIDC-EDKNGNTPLHIA 346
Query: 193 SREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGN 252
+R G ++ ++ G + H AA GF D + L + D+ G
Sbjct: 347 ARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGR 406
Query: 253 TPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTP 287
T LH AA GG +C + G D K+ ++P
Sbjct: 407 TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP 441
Score = 68.9 bits (167), Expect = 2e-11
Identities = 41/136 (30%), Positives = 71/136 (52%), Gaps = 1/136 (0%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
G + +K G V KD TPL A +SG I VVK+LL+ G ++N + + TPL
Sbjct: 184 GHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPL 243
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCR-LDTVKYLLDIGAKFQLEN 621
H AC+ GQ +V L++ GA+++ + TPL+ A S ++ L+ GA +++
Sbjct: 244 HVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKS 303
Query: 622 RKGHSAMDVAKAYADY 637
+ G + + + + +
Sbjct: 304 KDGKTPLHMTALHGRF 319
Score = 67.8 bits (164), Expect = 4e-11
Identities = 42/155 (27%), Positives = 81/155 (52%), Gaps = 1/155 (0%)
Query: 490 EKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGA 549
+K ++ ++ +G ++ +K + G+ ++ + Y TPL AC +G VV L++ GA
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 550 NVNATDNFLWTPLHFACHAGQQDI-VELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
VN + +TPLHFA + + +ELLV +GA ++ S + TPL+ R +
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
++ GA E++ G++ + +A Y +I+ +
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Score = 67.4 bits (163), Expect = 5e-11
Identities = 40/122 (32%), Positives = 65/122 (53%)
Query: 529 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAAS 588
L+ A +G+ D V+ L+ K +VN DN TPLH A + G +I+ELL+ SGA ++A
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 589 INNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLD 648
TPL+RA+ SC + V+ LL A ++ + + +A A + + + L
Sbjct: 72 SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131
Query: 649 NL 650
N+
Sbjct: 132 NV 133
Score = 66.2 bits (160), Expect = 1e-10
Identities = 62/239 (25%), Positives = 101/239 (42%), Gaps = 24/239 (10%)
Query: 492 VFSNINIITKAGDLASLKKAFES-----------GIPVDMKDNYYKTPLMTACASGNIDV 540
+ SN+N+ +AG A AF G ++ D + + A G+I+V
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEV 188
Query: 541 VKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIE 600
VK L+ GA V D +TPLH A +G +V+ L++ G ++ + +TPL+ A
Sbjct: 189 VKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACY 248
Query: 601 SCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLK 660
+ + V L+D GA +N KG + + A A L E L +
Sbjct: 249 NGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGA---LCLELLVGNGADVNMKSKD 305
Query: 661 GKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKK--------VQKGNVVHLNSLITSG 711
GKTP + + + ++ S G E K + G+ + +N+LITSG
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQS--GAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/139 (31%), Positives = 70/139 (50%), Gaps = 7/139 (5%)
Query: 509 KKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHA 568
+K SG +D D++ +T L A A GN++ + LL GA+ N D F +PLH+A
Sbjct: 389 RKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448
Query: 569 GQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDT----VKYLLDIGAKFQLENRKG 624
+ LV SGA ++ TPL+ A S DT ++YLL A + +++G
Sbjct: 449 CNYQCLFALVGSGASVNDLDERGCTPLHYAATS---DTDGKCLEYLLRNDANPGIRDKQG 505
Query: 625 HSAMDVAKAYADYRIIDLI 643
++A+ + AY + LI
Sbjct: 506 YNAVHYSAAYGHRLCLQLI 524
Score = 65.1 bits (157), Expect = 2e-10
Identities = 81/311 (26%), Positives = 122/311 (39%), Gaps = 34/311 (10%)
Query: 11 LQIYKVLQCVRNKDKKQIEKLTKLGYPELINYT---------EPINGLSALHLASVSNDI 61
+Q V+ C + + G+ LIN I+G+ LHLA++S
Sbjct: 326 IQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385
Query: 62 DMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYC 121
D LL G D D G T AA G+ + +L AD D G+ L Y
Sbjct: 386 DCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445
Query: 122 ILPTKRHYRCALIALEHGADVNNSTYEG-KPIFLRACEDAHDVKDVCLTF-LEKGANP-- 177
+Y+C + GA VN+ G P+ A D D K CL + L ANP
Sbjct: 446 --AANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDT-DGK--CLEYLLRNDANPGI 500
Query: 178 ------NAINSSTG---RTALMEASREGVVEIVRGILERGGEVNAFDNDRH---HAAHFA 225
NA++ S R L + E +++ ++E G D+D H A
Sbjct: 501 RDKQGYNAVHYSAAYGHRLCLQLIASETPLDV---LMETSGTDMLSDSDNRATISPLHLA 557
Query: 226 AKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKN-LDH 284
A G L++L D+ + + +G TPL AA G +C + +G + K+ +
Sbjct: 558 AYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILK 617
Query: 285 KTPRAVAKEGG 295
+TP A G
Sbjct: 618 RTPIHAAATNG 628
Score = 61.2 bits (147), Expect = 3e-09
Identities = 43/162 (26%), Positives = 80/162 (49%), Gaps = 12/162 (7%)
Query: 501 KAGDLASLKKAFESGIP------------VDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
K D SL +A +G P V+ +DN +TPL A G+ ++++ L+ G
Sbjct: 5 KLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSG 64
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
A VNA D+ TPLH A + ++ V++L++ A ++A N TPL+ A + + +
Sbjct: 65 ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNL 650
L+ + + + +R G +A+ A ++ L+ + N+
Sbjct: 125 ALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
Score = 61.2 bits (147), Expect = 3e-09
Identities = 58/233 (24%), Positives = 95/233 (40%), Gaps = 8/233 (3%)
Query: 33 KLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELG 92
K GY ++Y+ L L + +D++ D +R +P AA G
Sbjct: 503 KQGY-NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 561
Query: 93 HELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPI 152
H ++E+L ++ D+ + ++ G+ L K H C + + GA + Y K
Sbjct: 562 HHQALEVLVQSLLDLDVRNSSGRTPLDLAAF--KGHVECVDVLINQGASILVKDYILKRT 619
Query: 153 FLRACEDAHDVKDVCLTFLEKGANP-NAIN--SSTGRTALMEASREGVVEIVRGILERGG 209
+ A A + CL L A P NA++ G+T LM + G + V +L +G
Sbjct: 620 PIHAA--ATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
Query: 210 EVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGG 262
V+A D A H A G + + L + L G TP+H +A G
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
Score = 58.9 bits (141), Expect = 2e-08
Identities = 66/258 (25%), Positives = 100/258 (38%), Gaps = 8/258 (3%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
G +ALH A+ S +MV LL GA+ + D+ AA +GH +++L A++
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEV 199
Query: 108 TIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVC 167
T D + L + L+ G D+N G AC + DV V
Sbjct: 200 TCKDKKSYTPLHAAA--SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV--VV 255
Query: 168 LTFLEKGANPNAINSSTGRTAL--MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFA 225
++ GA N N G T L AS G + + ++ G +VN D H
Sbjct: 256 NELIDCGAIVNQKNEK-GFTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMT 313
Query: 226 AKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
A G F + + + NGNTPLH AA G + G D + +
Sbjct: 314 ALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGM 373
Query: 286 TPRAVAKEGGFKAASKEI 303
P +A GF +++
Sbjct: 374 FPLHLAALSGFSDCCRKL 391
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/220 (26%), Positives = 92/220 (41%), Gaps = 8/220 (3%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
NG + L L+ ++ D V LL+ GA+ D +D+ G T R A GHE ++ L + A
Sbjct: 652 NGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYE--GKPIFLRACEDAHDVK 164
+ D+ G+ + AL+ D N +T + G AC + H
Sbjct: 712 CLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGH--- 768
Query: 165 DVCLTFL--EKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAA 222
+ C+ L ++ N+ + + EG E++ L VNA D+
Sbjct: 769 ETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTL-GASIVNATDSKGRTPL 827
Query: 223 HFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGG 262
H AA + L+LL ++N V + G TPL AA G
Sbjct: 828 HAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENG 867
Score = 58.2 bits (139), Expect = 3e-08
Identities = 65/264 (24%), Positives = 105/264 (39%), Gaps = 12/264 (4%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
G +ALH +V+ + V LL GA ++D G TP +A GH + L ++ A M
Sbjct: 686 GRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASM 745
Query: 108 ----TIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDV 163
DN G L + H C + LE P+ D
Sbjct: 746 DANPATADNHGYTALHWACY--NGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGA 803
Query: 164 KDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAH 223
++ + L GA+ S GRT L A+ VE ++ +L +VN+ D+
Sbjct: 804 AEMLIDTL--GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLM 861
Query: 224 FAAKGGFFDILKLLF-AYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCD---LKW 279
AA+ G + +++L + + ++ L + NT LH A G I ++ D +
Sbjct: 862 MAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINA 921
Query: 280 KNLDHKTPRAVAKEGGFKAASKEI 303
N +TP VA G +E+
Sbjct: 922 TNAALQTPLHVAARNGLTMVVQEL 945
Score = 57.4 bits (137), Expect = 5e-08
Identities = 43/141 (30%), Positives = 65/141 (46%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
GD ++ SG V+ KD+ + TPL A AS + + V+ LL+ A+VNA D TPL
Sbjct: 52 GDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPL 111
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
H A E LV + ++ + T L+ A S + VK LL GA ++
Sbjct: 112 HIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDK 171
Query: 623 KGHSAMDVAKAYADYRIIDLI 643
K A+ A ++ L+
Sbjct: 172 KDRRAIHWAAYMGHIEVVKLL 192
Score = 57.0 bits (136), Expect = 7e-08
Identities = 38/145 (26%), Positives = 73/145 (50%), Gaps = 4/145 (2%)
Query: 488 DSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEK 547
D+ S +++ G +L+ +S + +D++++ +TPL A G+++ V L+ +
Sbjct: 546 DNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ 605
Query: 548 GANVNATDNFL-WTPLHFACHAGQQDIVELLV---ESGALIDAASINNSTPLNRAIESCR 603
GA++ D L TP+H A G + + LL+ E +D N TPL ++ +
Sbjct: 606 GASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGH 665
Query: 604 LDTVKYLLDIGAKFQLENRKGHSAM 628
D V LL+ GA +++ G +A+
Sbjct: 666 TDCVYSLLNKGANVDAKDKWGRTAL 690
Score = 55.8 bits (133), Expect = 1e-07
Identities = 37/131 (28%), Positives = 69/131 (52%), Gaps = 3/131 (2%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V+ +D ++TPL A A+ + + L+ +NVN +D T LH A +G ++V+LL
Sbjct: 100 VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 159
Query: 578 VESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADY 637
+ GA I+A + ++ A ++ VK L+ GA+ +++K ++ + A A
Sbjct: 160 LSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAA---ASS 216
Query: 638 RIIDLIKEKLD 648
+I ++K LD
Sbjct: 217 GMISVVKYLLD 227
Score = 54.3 bits (129), Expect = 4e-07
Identities = 102/471 (21%), Positives = 177/471 (37%), Gaps = 59/471 (12%)
Query: 186 RTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVG 245
RT L A+ G EI+ ++ G VNA D+ H A + +++L ++ DV
Sbjct: 42 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101
Query: 246 LISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRR 305
N TPLH AA C + + L N+ + R F
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPL---LSNVNVSDRAGRTALHHAAFSG------H 152
Query: 306 AERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVLDRGDGSISKNDFVMVLEE 365
E + L+R N R W+ A++ V + + + ++
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWA----AYMGHIEVVK-----LLVSHGAEVTCKD 203
Query: 366 RQDY------ASSEQLAAIAHLHEKTRGGGVNINE------------FFKGTRYL-NKSF 406
++ Y ASS ++ + +L + GV++NE + G + N+
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDL----GVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259
Query: 407 VLGSYGPKKKEKGM-----GKKGKKGKFVLPLPICVIPEYAFPRRQDGGPPYYMIETYKN 461
G+ +K EKG G L L + + + +DG P +M +
Sbjct: 260 DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM-KSKDGKTPLHMTALH-- 316
Query: 462 VTDSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSN-INIITKAGDLASLKKAFESGIPVDM 520
RF+R + IQ +V ID +K + ++I + G + SG
Sbjct: 317 ----GRFSRS---QTIIQSGAV--IDCEDKNGNTPLHIAARYGHELLINTLITSGADTAK 367
Query: 521 KDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVES 580
+ + PL A SG D + LL G +++ D+F T LH A G + + LL+ +
Sbjct: 368 RGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNT 427
Query: 581 GALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
GA + +PL+ A +C + L+ GA + +G + + A
Sbjct: 428 GADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 54.3 bits (129), Expect = 4e-07
Identities = 65/291 (22%), Positives = 110/291 (37%), Gaps = 47/291 (16%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDR-MGCTPTMRAAELGHELSMEIL---AK 102
+G + L LA+ ++ V L++ GA V+D + TP AA GH + +L A+
Sbjct: 582 SGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAE 641
Query: 103 AKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHD 162
+ + I D G+ L +L H C L GA+V+ G+ R H+
Sbjct: 642 PQNAVDIQDGNGQTPLMLSVL--NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHE 699
Query: 163 VKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNA----FDNDR 218
C+ L + + S GRT + ++ G + ++ +L+ ++A DN
Sbjct: 700 E---CVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756
Query: 219 HHAAHFAAKGGFFDILKLLF-------------------AYNGDVGLISI---------- 249
+ A H+A G ++LL N + G +
Sbjct: 757 YTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIV 816
Query: 250 -----NGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
G TPLH AA +C + + + + KTP +A E G
Sbjct: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENG 867
Score = 53.9 bits (128), Expect = 6e-07
Identities = 37/133 (27%), Positives = 63/133 (47%), Gaps = 4/133 (3%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
VD++D +TPLM + +G+ D V LL KGANV+A D + T LH G ++ V+ L
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 578 VESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE----NRKGHSAMDVAKA 633
++ GA TP++ + + + LL A + G++A+ A
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACY 765
Query: 634 YADYRIIDLIKEK 646
++L+ E+
Sbjct: 766 NGHETCVELLLEQ 778
Score = 53.5 bits (127), Expect = 7e-07
Identities = 61/247 (24%), Positives = 102/247 (41%), Gaps = 48/247 (19%)
Query: 14 YKVLQC-VRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSFLLDLGA 72
+ L C V N ++ E L ++N T+ G + LH A+ ++ ++ + LL A
Sbjct: 789 FSPLHCAVINDNEGAAEMLIDTLGASIVNATDS-KGRTPLHAAAFTDHVECLQLLLSHNA 847
Query: 73 HPDVQDRMGCTPTMRAAELGHELSMEIL-AKAKADMTIVDNEGKGVLFYCILPTKRHYRC 131
+ D G TP M AAE G ++E+L + A A++T+ DN L
Sbjct: 848 QVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHL----------- 896
Query: 132 ALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTG--RTAL 189
AC H+ L LEK + N IN++ +T L
Sbjct: 897 ------------------------ACSKGHETS--ALLILEKITDRNLINATNAALQTPL 930
Query: 190 MEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKG-GFFDILKLLFAYNGDVGLIS 248
A+R G+ +V+ +L +G V A D + + A A D L L+ A ++
Sbjct: 931 HVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILA-----TMMP 985
Query: 249 INGNTPL 255
++ ++PL
Sbjct: 986 VSSSSPL 992
Score = 52.4 bits (124), Expect = 2e-06
Identities = 56/225 (24%), Positives = 83/225 (36%), Gaps = 39/225 (17%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+G + LH+ ++ ++ GA D +D+ G TP AA GHEL + L + AD
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+G+ HG P+ L A D
Sbjct: 365 TA-----KRGI--------------------HGMF---------PLHLAALSG---FSDC 387
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
C L G + + + GRT L A+ G +E + +L G + N D H+AA
Sbjct: 388 CRKLLSSGFDIDTPDDF-GRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGF-ADCCKYI 270
+ L L V + G TPLHYAA C +Y+
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYL 491
Score = 51.2 bits (121), Expect = 4e-06
Identities = 35/130 (26%), Positives = 57/130 (43%)
Query: 514 SGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDI 573
+G V+MK KTPL G + +++ GA ++ D TPLH A G + +
Sbjct: 295 NGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELL 354
Query: 574 VELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKA 633
+ L+ SGA I+ PL+ A S D + LL G + G + + A A
Sbjct: 355 INTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAA 414
Query: 634 YADYRIIDLI 643
+ ++L+
Sbjct: 415 GGNLECLNLL 424
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/124 (29%), Positives = 64/124 (51%), Gaps = 3/124 (2%)
Query: 527 TPLMTACASGNIDVVKFLLEK-GAN-VNATDNFLWTPLHFACHAGQQDIVELLVESGALI 584
+PL A + N + L++ GA+ VNATD+ TPLH A + ++LL+ A +
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849
Query: 585 DAASINNSTPLNRAIESCRLDTVKYLL-DIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
++ TPL A E+ + +TV+ L+ A+ L++ ++A+ +A + LI
Sbjct: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909
Query: 644 KEKL 647
EK+
Sbjct: 910 LEKI 913
Score = 44.3 bits (103), Expect = 4e-04
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 3/78 (3%)
Query: 520 MKDNYYKTPLMTACASGNIDVVKFLLEKGAN---VNATDNFLWTPLHFACHAGQQDIVEL 576
++DN T L AC+ G+ +LEK + +NAT+ L TPLH A G +V+
Sbjct: 885 LQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQE 944
Query: 577 LVESGALIDAASINNSTP 594
L+ GA + A N TP
Sbjct: 945 LLGKGASVLAVDENGYTP 962
Score = 43.9 bits (102), Expect = 6e-04
Identities = 60/263 (22%), Positives = 93/263 (35%), Gaps = 42/263 (15%)
Query: 48 GLSALHLASVSNDIDMVSFLLD----LGAHPDVQDRMGCTPTMRAAELGHELSMEILAKA 103
G + +HL++ I ++ LL + A+P D G T A GHE +E+L +
Sbjct: 719 GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ 778
Query: 104 KADM-------------TIVDNEGKGVLFYCILPTK-------------------RHYRC 131
+ I DNEG + L H C
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
Query: 132 ALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALME 191
+ L H A VN+ GK + A E+ + + + + ++ TAL
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQT--NTVEMLVSSASAELTLQDNSKNTALHL 896
Query: 192 ASREGVVEIVRGILERGGE---VNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLIS 248
A +G ILE+ + +NA + H AA+ G +++ L V +
Sbjct: 897 ACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVD 956
Query: 249 INGNTP-LHYAAMGGFADCCKYI 270
NG TP L A ADC I
Sbjct: 957 ENGYTPALACAPNKDVADCLALI 979
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/65 (35%), Positives = 37/65 (56%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V+ D+ +TPL A + +++ ++ LL A VN+ D+ TPL A GQ + VE+L
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 578 VESGA 582
V S +
Sbjct: 876 VSSAS 880
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/127 (25%), Positives = 60/127 (47%), Gaps = 6/127 (4%)
Query: 188 ALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLI 247
+L++A G + VR ++ + +VN DN++ H AA G +I++LL V
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 248 SINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAE 307
TPLH A + + + + D+ ++ + +TP +A AA+K ++ AE
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA------AANKAVKCAE 124
Query: 308 RIANKLA 314
+ L+
Sbjct: 125 ALVPLLS 131
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/72 (31%), Positives = 37/72 (51%)
Query: 515 GIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIV 574
G VD KD + +T L +G+ + V LL+ GA D+ TP+H + G ++
Sbjct: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
Query: 575 ELLVESGALIDA 586
L++S A +DA
Sbjct: 736 GALLQSAASMDA 747
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 89.0 bits (219), Expect = 2e-17
Identities = 77/265 (29%), Positives = 106/265 (40%), Gaps = 20/265 (7%)
Query: 52 LHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVD 111
LH A+ N + +V +LL GA +D+ G P A GH E+L + A + + D
Sbjct: 688 LHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVAD 747
Query: 112 NEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV----- 166
L K Y + L+HGAD +G E D++D+
Sbjct: 748 LWKFTPLHEAA--AKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDA 805
Query: 167 ---------CLTFLEKGANPNAIN--SSTGR--TALMEASREGVVEIVRGILERGGEVNA 213
CL ++K P IN + GR T L A+ +E+ +LE G +VNA
Sbjct: 806 ALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA 865
Query: 214 FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQR 273
D H AA G DI LL YN V TPLH AA G C +
Sbjct: 866 QDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 925
Query: 274 GCDLKWKNLDHKTPRAVAKEGGFKA 298
G D KN + +TP +A +A
Sbjct: 926 GADPTMKNQEGQTPLDLATADDIRA 950
Score = 85.1 bits (209), Expect = 2e-16
Identities = 88/314 (28%), Positives = 129/314 (41%), Gaps = 44/314 (14%)
Query: 14 YKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVS---NDIDMVSFLLDL 70
+ +LQ R D +++K L E+IN+ +P + +ALH A S + LL
Sbjct: 491 HSLLQAAREADLAKVKKTLAL---EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK 547
Query: 71 GAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYR 130
GA+ + +++ TP AAE H ME+L K A M +D G+ L L H +
Sbjct: 548 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL--AGHLQ 605
Query: 131 CALIALEHGAD------------------VNNSTYEGKPI--------FLRACE--DAHD 162
+ L +G+D V E PI L A + D
Sbjct: 606 TCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLET 665
Query: 163 VKDVCLTFLEKGANPNAINSSTGR--TALMEASREGVVEIVRGILERGGEVNAFDNDRHH 220
VK +C N N GR T L A+ V +V +L G +V+A D
Sbjct: 666 VKQLC-----SSQNVNC-RDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLV 719
Query: 221 AAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWK 280
H A G +++ +LL + V + + TPLH AA G + CK + + G D K
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK 779
Query: 281 NLDHKTPRAVAKEG 294
N D TP + KEG
Sbjct: 780 NRDGNTPLDLVKEG 793
Score = 80.1 bits (196), Expect = 7e-15
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 4/147 (2%)
Query: 500 TKAGDLASLKKAFESGIPVDMKD--NYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
+KAGDL ++K+ S V+ +D + TPL A + VV++LL GA+V+A D
Sbjct: 658 SKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKG 716
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
PLH AC G ++ ELLV GA ++ A + TPL+ A + + K LL GA
Sbjct: 717 GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADP 776
Query: 618 QLENRKGHSAMDVAKAYADYRIIDLIK 644
+NR G++ +D+ K D I DL++
Sbjct: 777 TKKNRDGNTPLDLVKE-GDTDIQDLLR 802
Score = 72.4 bits (176), Expect = 2e-12
Identities = 55/167 (32%), Positives = 84/167 (50%), Gaps = 4/167 (2%)
Query: 503 GDLASLKKAFESGIPVDMKD--NYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
GD++ +K+ ++ V+ KD +PL A G DVV+ LL+ GANV+A D+
Sbjct: 193 GDVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
PLH AC G ++V LL+ GA +A N TPL+ A ++D LL GA +
Sbjct: 252 PLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIR 311
Query: 621 NRKGHSAMDVAKAYADYRII-DLIKEKLDNLPKPAENQKLKGKTPPI 666
N G SA+D+A A + + K++L + +KL P+
Sbjct: 312 NTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPL 358
Score = 71.6 bits (174), Expect = 3e-12
Identities = 41/110 (37%), Positives = 59/110 (53%)
Query: 522 DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESG 581
D TPL A + +V+ LL+ GA+V+A D PLH AC G ++ ELL++ G
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 425
Query: 582 ALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
A ++A + TPL+ A R++ LL GA L N G SA+D+A
Sbjct: 426 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 70.9 bits (172), Expect = 4e-12
Identities = 75/281 (26%), Positives = 114/281 (40%), Gaps = 24/281 (8%)
Query: 15 KVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSA-LHLASVSNDIDMVSFLLDLGAH 73
++L+ RN D ++++L +N + S+ LH A+ D+V LL +GA+
Sbjct: 185 ELLEACRNGDVSRVKRLVDAAN---VNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241
Query: 74 PDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCAL 133
+D G P A GH + +L AD DN L + K +
Sbjct: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAI--KGKIDVCI 299
Query: 134 IALEHGADVNNSTYEGKPIFLRACEDAHDV------KDVCLTFLEKG--------ANPNA 179
+ L+HGAD N +GK A A V KD L G P
Sbjct: 300 VLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLN 359
Query: 180 IN--SSTGR--TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILK 235
+N +S GR T L A+ V IV+ +L+ G +V+A D H A G +++ +
Sbjct: 360 VNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTE 419
Query: 236 LLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCD 276
LL + V + + TPLH AA + C + G D
Sbjct: 420 LLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGAD 460
Score = 66.2 bits (160), Expect = 1e-10
Identities = 39/107 (36%), Positives = 57/107 (53%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A N++V ++LLE GA+VNA D PLH A G DI LL++ ++A
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 898
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKA 633
TPL+ A + R LL GA ++N++G + +D+A A
Sbjct: 899 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
Score = 60.5 bits (145), Expect = 6e-09
Identities = 69/276 (25%), Positives = 107/276 (38%), Gaps = 36/276 (13%)
Query: 29 EKLTKLGYPELIN-YTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMR 87
EKL L P +N + + LHLA+ N + +V LL GA +D+ G P
Sbjct: 349 EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
Query: 88 AAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGAD---VN- 143
A GH E+L K A + +D L +K + L HGAD VN
Sbjct: 409 ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAA--SKNRVEVCSLLLSHGADPTLVNC 466
Query: 144 ----------------NSTYEGKPIFLRACEDAHDVKDV-------CLTFLEKGANPNAI 180
TYE K L D+ V + F + ++ A+
Sbjct: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETAL 526
Query: 181 NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY 240
+ + A + R+ V E+ +L +G VN + D H AA+ D++++L +
Sbjct: 527 HCAV---ASLHPKRKQVTEL---LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580
Query: 241 NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCD 276
+ + G T LH AA+ G C+ + G D
Sbjct: 581 GAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSD 616
Score = 59.7 bits (143), Expect = 1e-08
Identities = 42/130 (32%), Positives = 63/130 (48%), Gaps = 3/130 (2%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACAS---GNIDVVKFLLEKGANVNATDNF 557
+ DLA +KK I + ++T L A AS V + LL KGANVN +
Sbjct: 498 READLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKD 557
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
TPLH A D++E+L + GA ++A T L+RA + L T + LL G+
Sbjct: 558 FMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDP 617
Query: 618 QLENRKGHSA 627
+ + +G +A
Sbjct: 618 SIISLQGFTA 627
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/183 (27%), Positives = 75/183 (40%), Gaps = 54/183 (29%)
Query: 515 GIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIV 574
G V KD PL AC+ G+ +V + L+ GA+VN D + +TPLH A G+ +I
Sbjct: 707 GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEIC 766
Query: 575 ELLVESGA--------------------------------LIDAA--------------- 587
+LL++ GA L+DAA
Sbjct: 767 KLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE 826
Query: 588 SIN-------NSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRII 640
+IN NSTPL+ A L+ +YLL+ GA +++ G + A +Y I
Sbjct: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
Query: 641 DLI 643
L+
Sbjct: 887 ALL 889
Score = 51.6 bits (122), Expect = 3e-06
Identities = 29/86 (33%), Positives = 44/86 (51%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
E G V+ +D PL A + G++D+ L++ VNATD + +TPLH A G+
Sbjct: 858 EHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQ 917
Query: 573 IVELLVESGALIDAASINNSTPLNRA 598
+ LL+ GA + TPL+ A
Sbjct: 918 LCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 50.4 bits (119), Expect = 6e-06
Identities = 27/70 (38%), Positives = 39/70 (55%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ G V KD PL AC+ G+ +V + LL+ GA VNA D + +TPLH A + +
Sbjct: 390 QHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVE 449
Query: 573 IVELLVESGA 582
+ LL+ GA
Sbjct: 450 VCSLLLSHGA 459
Score = 49.7 bits (117), Expect = 1e-05
Identities = 50/175 (28%), Positives = 77/175 (44%), Gaps = 8/175 (4%)
Query: 154 LRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALME-ASREGVVEIVRGILERGGEVN 212
L AC + DV V L AN NA + + +++ + A+ G ++V +L+ G V+
Sbjct: 187 LEACRNG-DVSRV--KRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243
Query: 213 AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
A D+ H A G +++ LL D TPLH AA+ G D C + Q
Sbjct: 244 ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 303
Query: 273 RGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWAL 327
G D +N D K+ +A + E ++ E + + AR G N L AL
Sbjct: 304 HGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL--EAARSG--NEEKLMAL 354
Score = 43.9 bits (102), Expect = 6e-04
Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 1/93 (1%)
Query: 524 YYKTPLMTACASGNIDVVKFLLEK-GANVNATDNFLWTPLHFACHAGQQDIVELLVESGA 582
Y K L+ A SGN + + LL N +A+D TPLH A + IV+LL++ GA
Sbjct: 334 YKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGA 393
Query: 583 LIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ A PL+ A + + LL GA
Sbjct: 394 DVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA 426
Score = 33.5 bits (75), Expect = 0.77
Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 3/72 (4%)
Query: 560 TPLHFAC---HAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAK 616
T LH A H ++ + ELL+ GA ++ + + TPL+ A E D ++ L GAK
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
Query: 617 FQLENRKGHSAM 628
+ G +A+
Sbjct: 584 MNALDTLGQTAL 595
Score = 32.3 bits (72), Expect = 1.7
Identities = 19/68 (27%), Positives = 31/68 (45%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
GL LH A+ +D+ + L+ + D+ TP AA+ G +L AD
Sbjct: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
Query: 108 TIVDNEGK 115
T+ + EG+
Sbjct: 930 TMKNQEGQ 937
Score = 31.6 bits (70), Expect = 2.9
Identities = 20/72 (27%), Positives = 29/72 (40%)
Query: 540 VVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAI 599
V K + N T TPLH A ++ E L+E GA ++A PL+ A
Sbjct: 819 VQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAA 878
Query: 600 ESCRLDTVKYLL 611
+D L+
Sbjct: 879 SYGHVDIAALLI 890
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 87.0 bits (214), Expect = 6e-17
Identities = 78/280 (27%), Positives = 117/280 (41%), Gaps = 23/280 (8%)
Query: 28 IEKLTKLGYPELINYTEPINGLSA--LHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPT 85
+E + KL + +N + I G + LH A+ N + +V +LL GA +D+ G P
Sbjct: 505 VETVKKLCTVQSVNCRD-IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPL 563
Query: 86 MRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNS 145
A GH E+L K A + + D L K Y + L+HGAD
Sbjct: 564 HNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA--AKGKYEICKLLLQHGADPTKK 621
Query: 146 TYEGKPIFLRACEDAHDVKDV--------------CLTFLEKGANPNAIN--SSTGR--T 187
+G + D++D+ CL ++K ++P+ +N + GR T
Sbjct: 622 NRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHST 681
Query: 188 ALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLI 247
L A+ +E+ +L+ G +VNA D H AA G D+ LL YN V
Sbjct: 682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT 741
Query: 248 SINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTP 287
TPLH AA G C + G D KN + +TP
Sbjct: 742 DKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTP 781
Score = 82.8 bits (203), Expect = 1e-15
Identities = 80/321 (24%), Positives = 133/321 (41%), Gaps = 58/321 (18%)
Query: 14 YKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVS---NDIDMVSFLLDL 70
+ +LQ R D +I+K L E++N+ P +ALH A+ S + LL
Sbjct: 333 HSLLQAAREADVTRIKKHLSL---EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRK 389
Query: 71 GAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLF---YCILPTKR 127
GA+ + + + TP A+E H +E++ K +A + +DN G+ L YC
Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYC-----G 444
Query: 128 HYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRT 187
H + + L +G D N + +G E+ + L++G + + +S
Sbjct: 445 HLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL-------LQEGIS---LGNSEADR 494
Query: 188 ALMEASREGVVE----------------------------------IVRGILERGGEVNA 213
L+EA++ G VE +V +L+ G +V+A
Sbjct: 495 QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554
Query: 214 FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQR 273
D H A G +++ +LL + V + + TPLH AA G + CK + Q
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 614
Query: 274 GCDLKWKNLDHKTPRAVAKEG 294
G D KN D TP + K+G
Sbjct: 615 GADPTKKNRDGNTPLDLVKDG 635
Score = 79.0 bits (193), Expect = 2e-14
Identities = 52/146 (35%), Positives = 80/146 (54%), Gaps = 4/146 (2%)
Query: 501 KAGDLASLKKAFESGIPVDMKD--NYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL 558
KAGD+ ++KK V+ +D TPL A + VV++LL+ GA+V+A D
Sbjct: 501 KAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGG 559
Query: 559 WTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQ 618
PLH AC G ++ ELLV+ GA+++ A + TPL+ A + + K LL GA
Sbjct: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619
Query: 619 LENRKGHSAMDVAKAYADYRIIDLIK 644
+NR G++ +D+ K D I DL++
Sbjct: 620 KKNRDGNTPLDLVKD-GDTDIQDLLR 644
Score = 72.8 bits (177), Expect = 1e-12
Identities = 43/105 (40%), Positives = 59/105 (56%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPL A G DVV++LL+ GANV A D+ PLH AC G ++V LL+ GA +A
Sbjct: 60 TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
N TPL+ A ++D LL GA+ + N G +A+D+A
Sbjct: 120 RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Score = 72.4 bits (176), Expect = 2e-12
Identities = 76/291 (26%), Positives = 120/291 (41%), Gaps = 24/291 (8%)
Query: 15 KVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSA-LHLASVSNDIDMVSFLLDLGAH 73
++ + RN D +E++ +L PE +N + S LH A+ D+V +LL GA+
Sbjct: 27 ELFEACRNGD---VERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGAN 83
Query: 74 PDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCAL 133
+D G P A GH + +L + AD DN L + K +
Sbjct: 84 VQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGK--IDVCI 141
Query: 134 IALEHGADVNNSTYEGKPIFLRACEDAHDV------KDVCLTFLEKG--------ANPNA 179
+ L+HGA+ +G+ A A V KD L G P
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201
Query: 180 IN--SSTGR--TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILK 235
+N +S GR T L A+ V+IV+ +L+ G +V+A D H A G +++ +
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTE 261
Query: 236 LLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
LL + V + + TPLH AA + C + G D N +K+
Sbjct: 262 LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKS 312
Score = 71.2 bits (173), Expect = 3e-12
Identities = 41/110 (37%), Positives = 58/110 (52%)
Query: 522 DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESG 581
D TPL A + +V+ LL+ GA+V+A D PLH AC G ++ ELLV+ G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 582 ALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
A ++A + TPL+ A R++ LL GA L N SA+D+A
Sbjct: 268 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317
Score = 71.2 bits (173), Expect = 3e-12
Identities = 54/172 (31%), Positives = 83/172 (48%), Gaps = 3/172 (1%)
Query: 464 DSSRFNRDHPPEHPIQDDSVWYIDDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDN 523
D ++ NRD + D I D + + + K G LA +KK S V+ +D
Sbjct: 617 DPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKK-LSSPDNVNCRDT 675
Query: 524 Y--YKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESG 581
+ TPL A N++V ++LL+ GA+VNA D PLH A G D+ LL++
Sbjct: 676 QGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735
Query: 582 ALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKA 633
A ++A TPL+ A + R LL GA L+N++G + +D+ A
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
Score = 56.2 bits (134), Expect = 1e-07
Identities = 32/91 (35%), Positives = 51/91 (56%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
++G V +D+ PL AC+ G+ +VV LL GA+ NA DN+ +TPLH A G+ D
Sbjct: 79 QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKID 138
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCR 603
+ +L++ GA + + T L+ A S +
Sbjct: 139 VCIVLLQHGAEPTIRNTDGRTALDLADPSAK 169
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 3/133 (2%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASG---NIDVVKFLLEKGANVNATDNF 557
+ D+ +KK + ++T L A AS + + LL KGAN+N
Sbjct: 340 READVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKE 399
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
TPLH A D+VE++V+ A ++A T L+RA L T + LL G
Sbjct: 400 FLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDP 459
Query: 618 QLENRKGHSAMDV 630
+ + +G +A+ +
Sbjct: 460 NIISLQGFTALQM 472
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/150 (27%), Positives = 66/150 (44%), Gaps = 21/150 (14%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ G V KD PL AC+ G+ +V + L++ GA VNA D + +TPLH A + +
Sbjct: 232 QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVE 291
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR-----KGHSA 627
+ LL+ GA + +N K +D+ QL+ R KGHS
Sbjct: 292 VCSLLLSYGADPTLLNCHN----------------KSAIDLAPTPQLKERLAYEFKGHSL 335
Query: 628 MDVAKAYADYRIIDLIKEKLDNLPKPAENQ 657
+ A+ RI + ++ N P ++
Sbjct: 336 LQAAREADVTRIKKHLSLEMVNFKHPQTHE 365
Score = 52.0 bits (123), Expect = 2e-06
Identities = 59/231 (25%), Positives = 91/231 (39%), Gaps = 65/231 (28%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
+ G V KD PL AC+ G+ +V + L++ GA VN D + +TPLH A G+ +
Sbjct: 547 QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYE 606
Query: 573 IVELLVESGA--------------------------------LIDAA------------- 587
I +LL++ GA L+DAA
Sbjct: 607 ICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSS 666
Query: 588 --SIN-------NSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKG----HSA-----MD 629
++N +STPL+ A L+ +YLL GA +++ G H+A +D
Sbjct: 667 PDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVD 726
Query: 630 VAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEG--PEIKKEE 678
VA Y +K P QK + + +L G P +K +E
Sbjct: 727 VAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
Score = 50.4 bits (119), Expect = 6e-06
Identities = 69/276 (25%), Positives = 101/276 (36%), Gaps = 33/276 (11%)
Query: 49 LSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMT 108
L LH A ++ L+ GA + D TP AA +L AD T
Sbjct: 245 LVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPT 304
Query: 109 IVDNEGKGVLFYCILPTKRHYRC------ALIALEHGADVNN---------------STY 147
+++ K + P + +L+ ADV T+
Sbjct: 305 LLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTH 364
Query: 148 EGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGR--TALMEASREGVVEIVRGIL 205
E + A K +C L KGAN IN T T L AS + ++V ++
Sbjct: 365 E-TALHCAAASPYPKRKQICELLLRKGAN---INEKTKEFLTPLHVASEKAHNDVVEVVV 420
Query: 206 ERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFAD 265
+ +VNA DN + H AA G +LL +Y D +IS+ G T L MG +
Sbjct: 421 KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQ---MGN--E 475
Query: 266 CCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASK 301
+ + Q G L D + A AK G + K
Sbjct: 476 NVQQLLQEGISLGNSEADRQLLEA-AKAGDVETVKK 510
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/145 (28%), Positives = 64/145 (44%), Gaps = 6/145 (4%)
Query: 177 PNAINS--STGR--TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFD 232
P +NS + GR T L A+ G ++V +L+ G V A D+ H A G +
Sbjct: 46 PEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAE 105
Query: 233 ILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAK 292
++ LL + D TPLH AA+ G D C + Q G + +N D +T +A
Sbjct: 106 VVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLAD 165
Query: 293 EGGFKAASKEIRRAERIANKLARPG 317
+ E ++ E + + AR G
Sbjct: 166 PSAKAVLTGEYKKDELLES--ARSG 188
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/87 (31%), Positives = 40/87 (45%)
Query: 515 GIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIV 574
G ++ K + TPL A + DVV+ +++ A VNA DN T LH A + G
Sbjct: 390 GANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC 449
Query: 575 ELLVESGALIDAASINNSTPLNRAIES 601
LL+ G + S+ T L E+
Sbjct: 450 RLLLSYGCDPNIISLQGFTALQMGNEN 476
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 1/93 (1%)
Query: 524 YYKTPLMTACASGNIDVVKFLLEK-GANVNATDNFLWTPLHFACHAGQQDIVELLVESGA 582
Y K L+ + SGN + + LL N +A+D TPLH A + IV+LL++ GA
Sbjct: 176 YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGA 235
Query: 583 LIDAASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ A + PL+ A + + L+ GA
Sbjct: 236 DVHAKDKGDLVPLHNACSYGHYEVTELLVKHGA 268
Score = 30.8 bits (68), Expect = 5.0
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Query: 565 ACHAGQQDIVELLV--ESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
AC G + V+ LV E D A STPL+ A R D V+YLL GA Q +
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAG-RKSTPLHFAAGFGRKDVVEYLLQNGANVQARDD 89
Query: 623 KGHSAMDVAKAYADYRIIDLI 643
G + A ++ +++L+
Sbjct: 90 GGLIPLHNACSFGHAEVVNLL 110
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
1 [Homo sapiens]
Length = 1298
Score = 86.7 bits (213), Expect = 8e-17
Identities = 74/279 (26%), Positives = 120/279 (43%), Gaps = 45/279 (16%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
N S LH A+ + +D+ L+ GA+ D TP M AAE H +++ L KA A
Sbjct: 772 NKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGAL 831
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGA-DVNNSTYEGKPIFLRACEDAHDVKD 165
+ D EG L + K HY L +G DVN C+D
Sbjct: 832 VDPKDAEGSTCLH--LAAKKGHYEVVQYLLSNGQMDVN-------------CQD------ 870
Query: 166 VCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFA 225
G T ++ A+ V++V+ +L +G ++N DN+ + H+A
Sbjct: 871 -----------------DGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWA 913
Query: 226 AKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
A G DI ++L A D+ ++I+G++PLH AA DC R D+ KN + +
Sbjct: 914 AFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGE 973
Query: 286 TPRAVAKEGGFKAASKEIRRAERIANKLARPGAKNPNPL 324
TP A + + ++ A +++ L P+P+
Sbjct: 974 TPLQCA------SLNSQVWSALQMSKALQDSAPDRPSPV 1006
Score = 64.7 bits (156), Expect = 3e-10
Identities = 49/164 (29%), Positives = 74/164 (45%), Gaps = 5/164 (3%)
Query: 521 KDNYYKTPLMTACASGNIDVVKFLLEKGANVN--ATDNFLWTPLHFACHAGQQDIVELLV 578
K ++ L + G + V +L G + N +PLH A AG DI +LV
Sbjct: 734 KLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV 793
Query: 579 ESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYR 638
++GA ID S + TPL A E+ L+ VKYL+ GA ++ +G + + +A Y
Sbjct: 794 QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYE 853
Query: 639 IIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLS 682
++ + L N Q G TP I TE + + LLS
Sbjct: 854 VVQYL---LSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 894
Score = 64.7 bits (156), Expect = 3e-10
Identities = 42/165 (25%), Positives = 85/165 (51%), Gaps = 5/165 (3%)
Query: 496 INIITKAGDLASLKKAFESG-IPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNAT 554
+++ K G ++ +G + V+ +D+ TP++ A ++D+VK LL KG+++N
Sbjct: 843 LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR 902
Query: 555 DNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIG 614
DN LH+A +G DI E+L+ + + A +I+ +PL+ A R D V L
Sbjct: 903 DNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRD 962
Query: 615 AKFQLENRKGHSAMDVA----KAYADYRIIDLIKEKLDNLPKPAE 655
+ L+N++G + + A + ++ ++ +++ + P P E
Sbjct: 963 SDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVE 1007
Score = 57.8 bits (138), Expect = 4e-08
Identities = 40/147 (27%), Positives = 72/147 (48%), Gaps = 6/147 (4%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYY--KTPLMTACASGNIDVVKFLLEKGANVNATDNFL 558
+ G+L + GI + K + ++PL A +G++D+ L++ GAN++
Sbjct: 747 RQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQ 806
Query: 559 WTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIG-AKF 617
TPL A + V+ L+++GAL+D ST L+ A + + V+YLL G
Sbjct: 807 RTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDV 866
Query: 618 QLENRKGHSAMDVAKAYADYRIIDLIK 644
++ G + M A +Y+ +DL+K
Sbjct: 867 NCQDDGGWTPMIWA---TEYKHVDLVK 890
Score = 56.2 bits (134), Expect = 1e-07
Identities = 35/131 (26%), Positives = 65/131 (49%), Gaps = 1/131 (0%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
S ++ +AG + ++G +D +TPLM A + +++ VK+L++ GA V+
Sbjct: 775 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 834
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGAL-IDAASINNSTPLNRAIESCRLDTVKYLLD 612
D T LH A G ++V+ L+ +G + ++ TP+ A E +D VK LL
Sbjct: 835 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 894
Query: 613 IGAKFQLENRK 623
G+ + + +
Sbjct: 895 KGSDINIRDNE 905
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 81.3 bits (199), Expect = 3e-15
Identities = 80/287 (27%), Positives = 114/287 (39%), Gaps = 41/287 (14%)
Query: 43 TEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAK 102
++ G +AL A +D+V LL+ GA+ + + G TP M AA GH +L
Sbjct: 300 SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD 359
Query: 103 AKADMTIVDNEGK--GVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDA 160
A + NE K + C K H LE GAD + T E + AC D
Sbjct: 360 HGAGINTHSNEFKESALTLACY---KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 161 H------------------DVKDVCLT-------------FLEKGANPNAINSSTGRTAL 189
H D + LT +E+GAN +N G T L
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPL 475
Query: 190 MEASREGVVEIVRGILERGGEVNA-FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLIS 248
MEA+REG E+V +L +G +NA + + A A GGF ++ L D I
Sbjct: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IE 532
Query: 249 INGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
+ +TPL A+ G + KY+ G ++ T A E G
Sbjct: 533 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
Score = 67.4 bits (163), Expect = 5e-11
Identities = 64/251 (25%), Positives = 108/251 (43%), Gaps = 10/251 (3%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMG---CTPTMRAAELGHELSMEILAKAK 104
G S L LA + ++ LL + H +V+DR TP M A+ G+ +++L
Sbjct: 238 GESLLCLACSAGYYELAQVLLAM--HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD 295
Query: 105 ADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVK 164
AD+ G L Y + L GA++ + G + A H
Sbjct: 296 ADVNSQSATGNTALTYAC--AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH--V 351
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
+V L+ GA N ++ +AL A +G +++VR +LE G + ++ H A
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
A G ++ +LL V + + + +PL AA GG + + +RG +L+ N +
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 285 KTP-RAVAKEG 294
TP A+EG
Sbjct: 472 YTPLMEAAREG 482
Score = 65.1 bits (157), Expect = 2e-10
Identities = 48/150 (32%), Positives = 77/150 (51%), Gaps = 6/150 (4%)
Query: 504 DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA-TDNFLWTPL 562
+LA+L E G ++ ++ TPLM A G+ ++V LL +GAN+NA T+ T L
Sbjct: 452 ELAAL--LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
AC G ++ + L+++GA I+ + STPL A + L+ VKYLL GA
Sbjct: 510 TLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 623 KGHSAMDVAKAYADYRIIDLIKEKLDNLPK 652
G +A+ A + D++ + +L K
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLDK 596
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/150 (28%), Positives = 69/150 (46%), Gaps = 2/150 (1%)
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
L+ G VN T EG+ + AC + ++ L AN + T LM AS
Sbjct: 225 LDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANVEDRGNKGDITPLMAASSG 282
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G ++IV+ +L +VN+ + A +A GGF DI+K+L ++ + NG+TPL
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
AA G + + + G + + + K
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFK 372
Score = 62.0 bits (149), Expect = 2e-09
Identities = 36/89 (40%), Positives = 51/89 (57%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A + G +D+VK LL A+VN+ T L +AC G DIV++L+ GA I+
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ N TPL A + ++ + LLD GA
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/225 (25%), Positives = 90/225 (40%), Gaps = 34/225 (15%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
SAL LA +DMV FLL+ GA + + T M A GH +L + A + +
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLT 169
+ + L + H A + +E GA++ EG + A + H+ ++
Sbjct: 434 PADSFESPL--TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE--EMVAL 489
Query: 170 FLEKGANPNAINSSTGRTAL------------------------------MEASREGVVE 199
L +GAN NA T TAL MEAS+EG +E
Sbjct: 490 LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLE 549
Query: 200 IVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDV 244
+V+ +L G V+A A +A + G D+ +L D+
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
Score = 61.2 bits (147), Expect = 3e-09
Identities = 41/170 (24%), Positives = 81/170 (47%), Gaps = 1/170 (0%)
Query: 487 DDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMT-ACASGNIDVVKFLL 545
D +E + + AG + + + G ++ N +K +T AC G++D+V+FLL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 546 EKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLD 605
E GA+ + + T L AC G ++ LL++SGA ++ + + +PL A ++
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 606 TVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAE 655
L++ GA + N +G++ + A ++ L+ + N+ E
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Score = 61.2 bits (147), Expect = 3e-09
Identities = 37/130 (28%), Positives = 60/130 (46%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
S + + G L ++ E+G + K + T LM AC G+++V + LL+ GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+ +PL A G ++ LL+E GA ++ + TPL A + V LL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 614 GAKFQLENRK 623
GA + +
Sbjct: 494 GANINAQTEE 503
Score = 59.3 bits (142), Expect = 1e-08
Identities = 46/141 (32%), Positives = 64/141 (45%), Gaps = 4/141 (2%)
Query: 156 ACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFD 215
AC D DV V L++G + N ++ G + L A G E+ + +L V
Sbjct: 212 ACSDG-DVNAV-RKLLDEGRSVNE-HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 216 NDRHHAAHFAAK-GGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
N AA GG+ DI+KLL ++ DV S GNT L YA GGF D K + G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 275 CDLKWKNLDHKTPRAVAKEGG 295
+++ N + TP A G
Sbjct: 329 ANIEDHNENGHTPLMEAASAG 349
Score = 58.2 bits (139), Expect = 3e-08
Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 1/131 (0%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
T L ACA G +D+VK LL +GAN+ + TPL A AG ++ +L++ GA I+
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 366
Query: 587 ASIN-NSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKE 645
S + L A LD V++LL+ GA + + + H+A+ A + L+ +
Sbjct: 367 HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
Query: 646 KLDNLPKPAEN 656
+ PA++
Sbjct: 427 SGAQVNMPADS 437
Score = 57.0 bits (136), Expect = 7e-08
Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 2/133 (1%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL-WTP 561
GD+ +++K + G V+ ++ L AC++G ++ + LL ANV N TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L A G DIV+LL+ A +++ S +T L A +D VK LL+ GA + N
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 622 RKGHS-AMDVAKA 633
GH+ M+ A A
Sbjct: 336 ENGHTPLMEAASA 348
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/164 (27%), Positives = 76/164 (46%), Gaps = 5/164 (3%)
Query: 529 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALI-DAA 587
L AC+ G+++ V+ LL++G +VN + L AC AG ++ ++L+ A + D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 588 SINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKL 647
+ + TPL A LD VK LL A ++ G++A+ A A I+ ++ +
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 648 DNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTS 691
N+ EN G TP + ++ LL G+ T S
Sbjct: 329 ANIEDHNEN----GHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 81.3 bits (199), Expect = 3e-15
Identities = 80/287 (27%), Positives = 114/287 (39%), Gaps = 41/287 (14%)
Query: 43 TEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAK 102
++ G +AL A +D+V LL+ GA+ + + G TP M AA GH +L
Sbjct: 289 SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD 348
Query: 103 AKADMTIVDNEGK--GVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDA 160
A + NE K + C K H LE GAD + T E + AC D
Sbjct: 349 HGAGINTHSNEFKESALTLACY---KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 405
Query: 161 H------------------DVKDVCLT-------------FLEKGANPNAINSSTGRTAL 189
H D + LT +E+GAN +N G T L
Sbjct: 406 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPL 464
Query: 190 MEASREGVVEIVRGILERGGEVNA-FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLIS 248
MEA+REG E+V +L +G +NA + + A A GGF ++ L D I
Sbjct: 465 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IE 521
Query: 249 INGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
+ +TPL A+ G + KY+ G ++ T A E G
Sbjct: 522 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 568
Score = 67.4 bits (163), Expect = 5e-11
Identities = 64/251 (25%), Positives = 108/251 (43%), Gaps = 10/251 (3%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMG---CTPTMRAAELGHELSMEILAKAK 104
G S L LA + ++ LL + H +V+DR TP M A+ G+ +++L
Sbjct: 227 GESLLCLACSAGYYELAQVLLAM--HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD 284
Query: 105 ADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVK 164
AD+ G L Y + L GA++ + G + A H
Sbjct: 285 ADVNSQSATGNTALTYAC--AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH--V 340
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
+V L+ GA N ++ +AL A +G +++VR +LE G + ++ H A
Sbjct: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
A G ++ +LL V + + + +PL AA GG + + +RG +L+ N +
Sbjct: 401 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 460
Query: 285 KTP-RAVAKEG 294
TP A+EG
Sbjct: 461 YTPLMEAAREG 471
Score = 65.1 bits (157), Expect = 2e-10
Identities = 48/150 (32%), Positives = 77/150 (51%), Gaps = 6/150 (4%)
Query: 504 DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA-TDNFLWTPL 562
+LA+L E G ++ ++ TPLM A G+ ++V LL +GAN+NA T+ T L
Sbjct: 441 ELAAL--LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 498
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
AC G ++ + L+++GA I+ + STPL A + L+ VKYLL GA
Sbjct: 499 TLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTA 555
Query: 623 KGHSAMDVAKAYADYRIIDLIKEKLDNLPK 652
G +A+ A + D++ + +L K
Sbjct: 556 TGDTALTYACENGHTDVADVLLQAGADLDK 585
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/150 (28%), Positives = 69/150 (46%), Gaps = 2/150 (1%)
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
L+ G VN T EG+ + AC + ++ L AN + T LM AS
Sbjct: 214 LDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANVEDRGNKGDITPLMAASSG 271
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G ++IV+ +L +VN+ + A +A GGF DI+K+L ++ + NG+TPL
Sbjct: 272 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 331
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
AA G + + + G + + + K
Sbjct: 332 MEAASAGHVEVARVLLDHGAGINTHSNEFK 361
Score = 62.0 bits (149), Expect = 2e-09
Identities = 36/89 (40%), Positives = 51/89 (57%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A + G +D+VK LL A+VN+ T L +AC G DIV++L+ GA I+
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ N TPL A + ++ + LLD GA
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGA 351
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/225 (25%), Positives = 90/225 (40%), Gaps = 34/225 (15%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
SAL LA +DMV FLL+ GA + + T M A GH +L + A + +
Sbjct: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLT 169
+ + L + H A + +E GA++ EG + A + H+ ++
Sbjct: 423 PADSFESPL--TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE--EMVAL 478
Query: 170 FLEKGANPNAINSSTGRTAL------------------------------MEASREGVVE 199
L +GAN NA T TAL MEAS+EG +E
Sbjct: 479 LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLE 538
Query: 200 IVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDV 244
+V+ +L G V+A A +A + G D+ +L D+
Sbjct: 539 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
Score = 61.2 bits (147), Expect = 3e-09
Identities = 41/170 (24%), Positives = 81/170 (47%), Gaps = 1/170 (0%)
Query: 487 DDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMT-ACASGNIDVVKFLL 545
D +E + + AG + + + G ++ N +K +T AC G++D+V+FLL
Sbjct: 322 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381
Query: 546 EKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLD 605
E GA+ + + T L AC G ++ LL++SGA ++ + + +PL A ++
Sbjct: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
Query: 606 TVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAE 655
L++ GA + N +G++ + A ++ L+ + N+ E
Sbjct: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 491
Score = 61.2 bits (147), Expect = 3e-09
Identities = 37/130 (28%), Positives = 60/130 (46%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
S + + G L ++ E+G + K + T LM AC G+++V + LL+ GA VN
Sbjct: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+ +PL A G ++ LL+E GA ++ + TPL A + V LL
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Query: 614 GAKFQLENRK 623
GA + +
Sbjct: 483 GANINAQTEE 492
Score = 59.3 bits (142), Expect = 1e-08
Identities = 46/141 (32%), Positives = 64/141 (45%), Gaps = 4/141 (2%)
Query: 156 ACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFD 215
AC D DV V L++G + N ++ G + L A G E+ + +L V
Sbjct: 201 ACSDG-DVNAV-RKLLDEGRSVNE-HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
Query: 216 NDRHHAAHFAAK-GGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
N AA GG+ DI+KLL ++ DV S GNT L YA GGF D K + G
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 275 CDLKWKNLDHKTPRAVAKEGG 295
+++ N + TP A G
Sbjct: 318 ANIEDHNENGHTPLMEAASAG 338
Score = 58.2 bits (139), Expect = 3e-08
Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 1/131 (0%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
T L ACA G +D+VK LL +GAN+ + TPL A AG ++ +L++ GA I+
Sbjct: 296 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 355
Query: 587 ASIN-NSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKE 645
S + L A LD V++LL+ GA + + + H+A+ A + L+ +
Sbjct: 356 HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
Query: 646 KLDNLPKPAEN 656
+ PA++
Sbjct: 416 SGAQVNMPADS 426
Score = 57.0 bits (136), Expect = 7e-08
Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 2/133 (1%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL-WTP 561
GD+ +++K + G V+ ++ L AC++G ++ + LL ANV N TP
Sbjct: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L A G DIV+LL+ A +++ S +T L A +D VK LL+ GA + N
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
Query: 622 RKGHS-AMDVAKA 633
GH+ M+ A A
Sbjct: 325 ENGHTPLMEAASA 337
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/164 (27%), Positives = 76/164 (46%), Gaps = 5/164 (3%)
Query: 529 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALI-DAA 587
L AC+ G+++ V+ LL++G +VN + L AC AG ++ ++L+ A + D
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
Query: 588 SINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKL 647
+ + TPL A LD VK LL A ++ G++A+ A A I+ ++ +
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 648 DNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTS 691
N+ EN G TP + ++ LL G+ T S
Sbjct: 318 ANIEDHNEN----GHTPLMEAASAGHVEVARVLLDHGAGINTHS 357
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 81.3 bits (199), Expect = 3e-15
Identities = 80/287 (27%), Positives = 114/287 (39%), Gaps = 41/287 (14%)
Query: 43 TEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAK 102
++ G +AL A +D+V LL+ GA+ + + G TP M AA GH +L
Sbjct: 300 SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD 359
Query: 103 AKADMTIVDNEGK--GVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDA 160
A + NE K + C K H LE GAD + T E + AC D
Sbjct: 360 HGAGINTHSNEFKESALTLACY---KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 161 H------------------DVKDVCLT-------------FLEKGANPNAINSSTGRTAL 189
H D + LT +E+GAN +N G T L
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPL 475
Query: 190 MEASREGVVEIVRGILERGGEVNA-FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLIS 248
MEA+REG E+V +L +G +NA + + A A GGF ++ L D I
Sbjct: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IE 532
Query: 249 INGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
+ +TPL A+ G + KY+ G ++ T A E G
Sbjct: 533 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
Score = 79.0 bits (193), Expect = 2e-14
Identities = 71/252 (28%), Positives = 108/252 (42%), Gaps = 35/252 (13%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
S L LA+ +++ + L++ GA+ + + G TP M AA GHE + +L A++
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 110 VDNE------------------------GKGVLFYCILPTKR-----HYRCALIALEHGA 140
E G + C P H L GA
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGA 559
Query: 141 DVNNSTYEGKPIFLRACEDAH-DVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVE 199
+V+ +T G ACE+ H DV DV L+ GA+ S GRT LM+A+R G +
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADV---LLQAGADLEH-ESEGGRTPLMKAARAGHLC 615
Query: 200 IVRGILERGGEVN-AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYA 258
V+ ++ +G VN A N+ H A GG +++LL A+ D +G+T L A
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675
Query: 259 AMGGFADCCKYI 270
A GG + Y+
Sbjct: 676 AKGGHTNVVSYL 687
Score = 75.9 bits (185), Expect = 1e-13
Identities = 75/281 (26%), Positives = 115/281 (40%), Gaps = 37/281 (13%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
SAL LA +DMV FLL+ GA + + T M A GH +L + A + +
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLT 169
+ + L + H A + +E GA++ EG + A + H+ ++
Sbjct: 434 PADSFESPL--TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE--EMVAL 489
Query: 170 FLEKGANPNAINSSTGRTAL------------------------------MEASREGVVE 199
L +GAN NA T TAL MEAS+EG +E
Sbjct: 490 LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLE 549
Query: 200 IVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAA 259
+V+ +L G V+A A +A + G D+ +L D+ S G TPL AA
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
Query: 260 MGGFADCCKYIAQRGCDLK--WKNLDHKTPRAVAKEGGFKA 298
G +++ +G ++ N DH T ++A GG A
Sbjct: 610 RAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLA 649
Score = 75.1 bits (183), Expect = 2e-13
Identities = 64/229 (27%), Positives = 102/229 (44%), Gaps = 6/229 (2%)
Query: 52 LHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVD 111
L LA ++V LL GA+ + ++ TP AA G+ ++IL A A++
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
Query: 112 NEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLR-ACEDAHDVKDVCLTF 170
G+ + H + L+ G+D+N + L AC +V
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR--AEVVSLL 1243
Query: 171 LEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNA--FDNDRHHAAHFAAKG 228
L++ AN + TG T LMEA+ G E+ R +L++G +VNA + R A AA
Sbjct: 1244 LDRKANVEH-RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
Query: 229 GFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
G + +LL + + + GNTPL A+ GG D + + Q G D+
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Score = 72.4 bits (176), Expect = 2e-12
Identities = 53/168 (31%), Positives = 86/168 (51%), Gaps = 8/168 (4%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A G++++VK+LL GANV+AT T L +AC G D+ ++L+++GA ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKF-QLENRKGHSAMDVAKAYADYRIIDLIKE 645
S TPL +A + L TV++L+ GA + H+ + +A A +++L+
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELL-- 654
Query: 646 KLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEELL---SSIYGVPTT 690
L + P K G T I +G LL +++ VPTT
Sbjct: 655 -LAHGADPTHRLK-DGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTT 700
Score = 67.4 bits (163), Expect = 5e-11
Identities = 64/251 (25%), Positives = 108/251 (43%), Gaps = 10/251 (3%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMG---CTPTMRAAELGHELSMEILAKAK 104
G S L LA + ++ LL + H +V+DR TP M A+ G+ +++L
Sbjct: 238 GESLLCLACSAGYYELAQVLLAM--HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD 295
Query: 105 ADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVK 164
AD+ G L Y + L GA++ + G + A H
Sbjct: 296 ADVNSQSATGNTALTYAC--AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH--V 351
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
+V L+ GA N ++ +AL A +G +++VR +LE G + ++ H A
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
A G ++ +LL V + + + +PL AA GG + + +RG +L+ N +
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 285 KTP-RAVAKEG 294
TP A+EG
Sbjct: 472 YTPLMEAAREG 482
Score = 67.4 bits (163), Expect = 5e-11
Identities = 71/281 (25%), Positives = 116/281 (41%), Gaps = 12/281 (4%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
+AL LA ++VS L+ A + +D+ G TP + AA GH +EIL D+
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLT 169
K R L+ + + + P+ L A + ++
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA---SGGYVNIIKI 1173
Query: 170 FLEKGANPNA-INSSTGRTALMEASREGVVEIVRGILERGGEVNA-FDNDRHHAAHFAAK 227
L GA N+ S G + LM A+ G V V+ +L+ G ++NA + +R+ A A
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 228 GGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTP 287
G +++ LL +V + G TPL AA GG+A+ + + +G D+ +
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 288 RAV---AKEGGFKAASKEIRRAERIANKLARPGAKNPNPLW 325
A+ A +G +K I R I + K PLW
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVR----NKKGNTPLW 1330
Score = 66.6 bits (161), Expect = 8e-11
Identities = 51/162 (31%), Positives = 83/162 (51%), Gaps = 10/162 (6%)
Query: 504 DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA-TDNFLWTPL 562
+LA+L E G ++ ++ TPLM A G+ ++V LL +GAN+NA T+ T L
Sbjct: 452 ELAAL--LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
AC G ++ + L+++GA I+ + STPL A + L+ VKYLL GA
Sbjct: 510 TLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 623 KGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
G +A+ A + D++ + +L E++ G+TP
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADL----EHESEGGRTP 604
Score = 65.9 bits (159), Expect = 1e-10
Identities = 36/108 (33%), Positives = 67/108 (62%), Gaps = 3/108 (2%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA-TDNFLWTPLHFACHAGQQDIVEL 576
++ +D TPL+ A +G++ VV+ LL+KG ++ A ++ TPL AC G+Q++V+L
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
Query: 577 LVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKG 624
L+ GA + ++++ TPL+ A ++ +K LL+ GA ++ +R G
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA--EINSRTG 1186
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/150 (28%), Positives = 69/150 (46%), Gaps = 2/150 (1%)
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
L+ G VN T EG+ + AC + ++ L AN + T LM AS
Sbjct: 225 LDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANVEDRGNKGDITPLMAASSG 282
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G ++IV+ +L +VN+ + A +A GGF DI+K+L ++ + NG+TPL
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
AA G + + + G + + + K
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFK 372
Score = 62.0 bits (149), Expect = 2e-09
Identities = 36/89 (40%), Positives = 51/89 (57%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A + G +D+VK LL A+VN+ T L +AC G DIV++L+ GA I+
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ N TPL A + ++ + LLD GA
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 61.2 bits (147), Expect = 3e-09
Identities = 41/170 (24%), Positives = 81/170 (47%), Gaps = 1/170 (0%)
Query: 487 DDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMT-ACASGNIDVVKFLL 545
D +E + + AG + + + G ++ N +K +T AC G++D+V+FLL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 546 EKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLD 605
E GA+ + + T L AC G ++ LL++SGA ++ + + +PL A ++
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 606 TVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAE 655
L++ GA + N +G++ + A ++ L+ + N+ E
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Score = 61.2 bits (147), Expect = 3e-09
Identities = 37/130 (28%), Positives = 60/130 (46%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
S + + G L ++ E+G + K + T LM AC G+++V + LL+ GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+ +PL A G ++ LL+E GA ++ + TPL A + V LL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 614 GAKFQLENRK 623
GA + +
Sbjct: 494 GANINAQTEE 503
Score = 60.8 bits (146), Expect = 5e-09
Identities = 49/180 (27%), Positives = 92/180 (51%), Gaps = 10/180 (5%)
Query: 490 EKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYK-TPLMTACASGNIDVVKFLLEKG 548
+K F+ + + AG + ++ + G ++ + K TPL AC+ G +VV LL +G
Sbjct: 1086 KKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARG 1145
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA--ASINNSTPLNRAIESCRLDT 606
AN + +TPL A G +I+++L+ +GA I++ S +PL A + +
Sbjct: 1146 ANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPA 1205
Query: 607 VKYLLDIGAKF--QLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
VK LLD+G+ Q+E + ++A+ +A ++ L+ ++ N+ E++ G TP
Sbjct: 1206 VKLLLDMGSDINAQIETNR-NTALTLACFQGRAEVVSLLLDRKANV----EHRAKTGLTP 1260
Score = 59.7 bits (143), Expect = 1e-08
Identities = 54/232 (23%), Positives = 102/232 (43%), Gaps = 10/232 (4%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQ--DRMGCTPTMRAAELGHELSMEILAKA 103
++ + L LA+ ++++ LL+ GA + + ++G +P M AA GH ++++L
Sbjct: 1153 VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDM 1212
Query: 104 KADMT--IVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAH 161
+D+ I N + C + + L+ A+V + G + A +
Sbjct: 1213 GSDINAQIETNRNTALTLACF---QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1269
Query: 162 DVKDVCLTFLEKGANPNAINSSTGR-TALMEASREGVVEIVRGILERGGEVNAFDNDRHH 220
+V L+KGA+ NA + R TAL A+ +G + ++ RG ++ + +
Sbjct: 1270 --AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNT 1327
Query: 221 AAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
A+ GG FD+++LL DV TPL A G +Y+ +
Sbjct: 1328 PLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 59.3 bits (142), Expect = 1e-08
Identities = 46/141 (32%), Positives = 64/141 (45%), Gaps = 4/141 (2%)
Query: 156 ACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFD 215
AC D DV V L++G + N ++ G + L A G E+ + +L V
Sbjct: 212 ACSDG-DVNAV-RKLLDEGRSVNE-HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 216 NDRHHAAHFAAK-GGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
N AA GG+ DI+KLL ++ DV S GNT L YA GGF D K + G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 275 CDLKWKNLDHKTPRAVAKEGG 295
+++ N + TP A G
Sbjct: 329 ANIEDHNENGHTPLMEAASAG 349
Score = 58.2 bits (139), Expect = 3e-08
Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 1/131 (0%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
T L ACA G +D+VK LL +GAN+ + TPL A AG ++ +L++ GA I+
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 366
Query: 587 ASIN-NSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKE 645
S + L A LD V++LL+ GA + + + H+A+ A + L+ +
Sbjct: 367 HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
Query: 646 KLDNLPKPAEN 656
+ PA++
Sbjct: 427 SGAQVNMPADS 437
Score = 57.0 bits (136), Expect = 7e-08
Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 2/133 (1%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL-WTP 561
GD+ +++K + G V+ ++ L AC++G ++ + LL ANV N TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L A G DIV+LL+ A +++ S +T L A +D VK LL+ GA + N
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 622 RKGHS-AMDVAKA 633
GH+ M+ A A
Sbjct: 336 ENGHTPLMEAASA 348
Score = 56.2 bits (134), Expect = 1e-07
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
Query: 522 DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESG 581
++ + T L ACA G+ ++V L+ + A + D +TPL A AG +VE+L++ G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 582 ALIDAAS-INNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRII 640
I+A S TPL+ A R + V LL GA + N ++ + +A + II
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 641 DLI 643
++
Sbjct: 1172 KIL 1174
Score = 54.7 bits (130), Expect = 3e-07
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 6/178 (3%)
Query: 40 INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
IN N +AL LA ++VS LLD A+ + + + G TP M AA G+ +
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
Query: 100 LAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACED 159
L AD+ I K HY+ + + GA ++ +G A
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 160 AHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
H DV ++ GA+ +A ++ T LM A R+G V++V+ +++ EVN F +D
Sbjct: 1336 GH--FDVVQLLVQAGADVDAADNRK-ITPLMSAFRKGHVKVVQYLVK---EVNQFPSD 1387
Score = 53.9 bits (128), Expect = 6e-07
Identities = 45/193 (23%), Positives = 90/193 (46%), Gaps = 7/193 (3%)
Query: 503 GDLASLKKAFESGIPVDMK-DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
G + ++K + G ++ + + T L AC G +VV LL++ ANV TP
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNS--TPLNRAIESCRLDTVKYLLDIGAKFQL 619
L A G ++ +L++ GA ++A + +S T L A + + L+ GA +
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 620 ENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEE 679
N+KG++ + +A + ++ L+ + ++ A+N+K+ TP + +K +
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADV-DAADNRKI---TPLMSAFRKGHVKVVQY 1376
Query: 680 LLSSIYGVPTTSE 692
L+ + P+ E
Sbjct: 1377 LVKEVNQFPSDIE 1389
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/164 (27%), Positives = 76/164 (46%), Gaps = 5/164 (3%)
Query: 529 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALI-DAA 587
L AC+ G+++ V+ LL++G +VN + L AC AG ++ ++L+ A + D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 588 SINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKL 647
+ + TPL A LD VK LL A ++ G++A+ A A I+ ++ +
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 648 DNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTS 691
N+ EN G TP + ++ LL G+ T S
Sbjct: 329 ANIEDHNEN----GHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/178 (27%), Positives = 75/178 (42%), Gaps = 14/178 (7%)
Query: 500 TKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLW 559
++ G L +K SG V T L AC +G+ DV LL+ GA++
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNS-TPLNRAIESCRLDTVKYLLDIGA--- 615
TPL A AG V+ L+ GA ++ A+ NN T ++ A L V+ LL GA
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Query: 616 -------KFQLENRKGHSAMDVAKAYADY--RIIDLIKEKLDNLPKPAENQKLKGKTP 664
+E KG +V DY ++ + + LP P+++Q + P
Sbjct: 663 HRLKDGSTMLIEAAKG-GHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVP 719
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/110 (28%), Positives = 51/110 (46%), Gaps = 1/110 (0%)
Query: 188 ALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLI 247
+L EA +G V VR +L+ G VN + A G++++ ++L A + +V
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 248 SINGN-TPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGF 296
G+ TPL A+ GG+ D K + D+ ++ T A GGF
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
Score = 44.7 bits (104), Expect = 3e-04
Identities = 38/143 (26%), Positives = 62/143 (43%), Gaps = 3/143 (2%)
Query: 178 NAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLL 237
+A S TAL A G E+V ++ R ++ D AA G ++++L
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 238 FAYNGDVGLIS-INGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGF 296
GD+ S +TPL A GG + + RG + + +N+ TP ++A GG+
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167
Query: 297 KAASKEIRRAERIANKLARPGAK 319
K + A N +R G+K
Sbjct: 1168 VNIIKILLNAGAEIN--SRTGSK 1188
Score = 43.9 bits (102), Expect = 6e-04
Identities = 35/138 (25%), Positives = 55/138 (39%), Gaps = 14/138 (10%)
Query: 35 GYPELINY---------TEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPT 85
G+ EL+ Y G +AL A + D+ LL GA + + G TP
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
Query: 86 MRAAELGHELSMEILAK--AKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVN 143
M+AA GH +++ L A + +N+ V C H + L HGAD
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC---AGGHLAVVELLLAHGADPT 662
Query: 144 NSTYEGKPIFLRACEDAH 161
+ +G + + A + H
Sbjct: 663 HRLKDGSTMLIEAAKGGH 680
Score = 32.3 bits (72), Expect = 1.7
Identities = 15/50 (30%), Positives = 29/50 (58%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEK 547
+ + G ++ ++G VD DN TPLM+A G++ VV++L+++
Sbjct: 1331 LASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 31.2 bits (69), Expect = 3.8
Identities = 23/88 (26%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 210 EVNAFDNDRHHAA-HFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCK 268
+++A H A A GG +++ +L A + + G TPL AA G +
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 269 YIAQRGCDLKWKNLDHK-TPRAVAKEGG 295
+ +G D++ ++ K TP ++A GG
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGG 1133
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 81.3 bits (199), Expect = 3e-15
Identities = 80/287 (27%), Positives = 114/287 (39%), Gaps = 41/287 (14%)
Query: 43 TEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAK 102
++ G +AL A +D+V LL+ GA+ + + G TP M AA GH +L
Sbjct: 300 SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD 359
Query: 103 AKADMTIVDNEGK--GVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDA 160
A + NE K + C K H LE GAD + T E + AC D
Sbjct: 360 HGAGINTHSNEFKESALTLACY---KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 161 H------------------DVKDVCLT-------------FLEKGANPNAINSSTGRTAL 189
H D + LT +E+GAN +N G T L
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPL 475
Query: 190 MEASREGVVEIVRGILERGGEVNA-FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLIS 248
MEA+REG E+V +L +G +NA + + A A GGF ++ L D I
Sbjct: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IE 532
Query: 249 INGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGG 295
+ +TPL A+ G + KY+ G ++ T A E G
Sbjct: 533 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
Score = 79.0 bits (193), Expect = 2e-14
Identities = 71/252 (28%), Positives = 108/252 (42%), Gaps = 35/252 (13%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
S L LA+ +++ + L++ GA+ + + G TP M AA GHE + +L A++
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
Query: 110 VDNE------------------------GKGVLFYCILPTKR-----HYRCALIALEHGA 140
E G + C P H L GA
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGA 559
Query: 141 DVNNSTYEGKPIFLRACEDAH-DVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVE 199
+V+ +T G ACE+ H DV DV L+ GA+ S GRT LM+A+R G +
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADV---LLQAGADLEH-ESEGGRTPLMKAARAGHLC 615
Query: 200 IVRGILERGGEVN-AFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYA 258
V+ ++ +G VN A N+ H A GG +++LL A+ D +G+T L A
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675
Query: 259 AMGGFADCCKYI 270
A GG + Y+
Sbjct: 676 AKGGHTNVVSYL 687
Score = 75.9 bits (185), Expect = 1e-13
Identities = 75/281 (26%), Positives = 115/281 (40%), Gaps = 37/281 (13%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
SAL LA +DMV FLL+ GA + + T M A GH +L + A + +
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLT 169
+ + L + H A + +E GA++ EG + A + H+ ++
Sbjct: 434 PADSFESPL--TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE--EMVAL 489
Query: 170 FLEKGANPNAINSSTGRTAL------------------------------MEASREGVVE 199
L +GAN NA T TAL MEAS+EG +E
Sbjct: 490 LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLE 549
Query: 200 IVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAA 259
+V+ +L G V+A A +A + G D+ +L D+ S G TPL AA
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
Query: 260 MGGFADCCKYIAQRGCDLK--WKNLDHKTPRAVAKEGGFKA 298
G +++ +G ++ N DH T ++A GG A
Sbjct: 610 RAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLA 649
Score = 75.1 bits (183), Expect = 2e-13
Identities = 64/229 (27%), Positives = 102/229 (44%), Gaps = 6/229 (2%)
Query: 52 LHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVD 111
L LA ++V LL GA+ + ++ TP AA G+ ++IL A A++
Sbjct: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
Query: 112 NEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLR-ACEDAHDVKDVCLTF 170
G+ + H + L+ G+D+N + L AC +V
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR--AEVVSLL 1243
Query: 171 LEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNA--FDNDRHHAAHFAAKG 228
L++ AN + TG T LMEA+ G E+ R +L++G +VNA + R A AA
Sbjct: 1244 LDRKANVEH-RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
Query: 229 GFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDL 277
G + +LL + + + GNTPL A+ GG D + + Q G D+
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
Score = 72.4 bits (176), Expect = 2e-12
Identities = 53/168 (31%), Positives = 86/168 (51%), Gaps = 8/168 (4%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A G++++VK+LL GANV+AT T L +AC G D+ ++L+++GA ++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKF-QLENRKGHSAMDVAKAYADYRIIDLIKE 645
S TPL +A + L TV++L+ GA + H+ + +A A +++L+
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELL-- 654
Query: 646 KLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEELL---SSIYGVPTT 690
L + P K G T I +G LL +++ VPTT
Sbjct: 655 -LAHGADPTHRLK-DGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTT 700
Score = 67.4 bits (163), Expect = 5e-11
Identities = 64/251 (25%), Positives = 108/251 (43%), Gaps = 10/251 (3%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMG---CTPTMRAAELGHELSMEILAKAK 104
G S L LA + ++ LL + H +V+DR TP M A+ G+ +++L
Sbjct: 238 GESLLCLACSAGYYELAQVLLAM--HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD 295
Query: 105 ADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVK 164
AD+ G L Y + L GA++ + G + A H
Sbjct: 296 ADVNSQSATGNTALTYAC--AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGH--V 351
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
+V L+ GA N ++ +AL A +G +++VR +LE G + ++ H A
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
A G ++ +LL V + + + +PL AA GG + + +RG +L+ N +
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
Query: 285 KTP-RAVAKEG 294
TP A+EG
Sbjct: 472 YTPLMEAAREG 482
Score = 67.4 bits (163), Expect = 5e-11
Identities = 71/281 (25%), Positives = 116/281 (41%), Gaps = 12/281 (4%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
+AL LA ++VS L+ A + +D+ G TP + AA GH +EIL D+
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLT 169
K R L+ + + + P+ L A + ++
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA---SGGYVNIIKI 1173
Query: 170 FLEKGANPNA-INSSTGRTALMEASREGVVEIVRGILERGGEVNA-FDNDRHHAAHFAAK 227
L GA N+ S G + LM A+ G V V+ +L+ G ++NA + +R+ A A
Sbjct: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
Query: 228 GGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTP 287
G +++ LL +V + G TPL AA GG+A+ + + +G D+ +
Sbjct: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
Query: 288 RAV---AKEGGFKAASKEIRRAERIANKLARPGAKNPNPLW 325
A+ A +G +K I R I + K PLW
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHIDVR----NKKGNTPLW 1330
Score = 66.6 bits (161), Expect = 8e-11
Identities = 51/162 (31%), Positives = 83/162 (51%), Gaps = 10/162 (6%)
Query: 504 DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA-TDNFLWTPL 562
+LA+L E G ++ ++ TPLM A G+ ++V LL +GAN+NA T+ T L
Sbjct: 452 ELAAL--LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
AC G ++ + L+++GA I+ + STPL A + L+ VKYLL GA
Sbjct: 510 TLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 623 KGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
G +A+ A + D++ + +L E++ G+TP
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADL----EHESEGGRTP 604
Score = 65.9 bits (159), Expect = 1e-10
Identities = 36/108 (33%), Positives = 67/108 (62%), Gaps = 3/108 (2%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA-TDNFLWTPLHFACHAGQQDIVEL 576
++ +D TPL+ A +G++ VV+ LL+KG ++ A ++ TPL AC G+Q++V+L
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
Query: 577 LVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKG 624
L+ GA + ++++ TPL+ A ++ +K LL+ GA ++ +R G
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA--EINSRTG 1186
Score = 62.0 bits (149), Expect = 2e-09
Identities = 42/150 (28%), Positives = 69/150 (46%), Gaps = 2/150 (1%)
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
L+ G VN T EG+ + AC + ++ L AN + T LM AS
Sbjct: 225 LDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANVEDRGNKGDITPLMAASSG 282
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G ++IV+ +L +VN+ + A +A GGF DI+K+L ++ + NG+TPL
Sbjct: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
AA G + + + G + + + K
Sbjct: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFK 372
Score = 62.0 bits (149), Expect = 2e-09
Identities = 36/89 (40%), Positives = 51/89 (57%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A + G +D+VK LL A+VN+ T L +AC G DIV++L+ GA I+
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ N TPL A + ++ + LLD GA
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGA 362
Score = 61.2 bits (147), Expect = 3e-09
Identities = 41/170 (24%), Positives = 81/170 (47%), Gaps = 1/170 (0%)
Query: 487 DDSEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMT-ACASGNIDVVKFLL 545
D +E + + AG + + + G ++ N +K +T AC G++D+V+FLL
Sbjct: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
Query: 546 EKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLD 605
E GA+ + + T L AC G ++ LL++SGA ++ + + +PL A ++
Sbjct: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
Query: 606 TVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAE 655
L++ GA + N +G++ + A ++ L+ + N+ E
Sbjct: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
Score = 61.2 bits (147), Expect = 3e-09
Identities = 37/130 (28%), Positives = 60/130 (46%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
S + + G L ++ E+G + K + T LM AC G+++V + LL+ GA VN
Sbjct: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+ +PL A G ++ LL+E GA ++ + TPL A + V LL
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 614 GAKFQLENRK 623
GA + +
Sbjct: 494 GANINAQTEE 503
Score = 60.8 bits (146), Expect = 5e-09
Identities = 49/180 (27%), Positives = 92/180 (51%), Gaps = 10/180 (5%)
Query: 490 EKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYK-TPLMTACASGNIDVVKFLLEKG 548
+K F+ + + AG + ++ + G ++ + K TPL AC+ G +VV LL +G
Sbjct: 1086 KKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARG 1145
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA--ASINNSTPLNRAIESCRLDT 606
AN + +TPL A G +I+++L+ +GA I++ S +PL A + +
Sbjct: 1146 ANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPA 1205
Query: 607 VKYLLDIGAKF--QLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
VK LLD+G+ Q+E + ++A+ +A ++ L+ ++ N+ E++ G TP
Sbjct: 1206 VKLLLDMGSDINAQIETNR-NTALTLACFQGRAEVVSLLLDRKANV----EHRAKTGLTP 1260
Score = 59.7 bits (143), Expect = 1e-08
Identities = 54/232 (23%), Positives = 102/232 (43%), Gaps = 10/232 (4%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQ--DRMGCTPTMRAAELGHELSMEILAKA 103
++ + L LA+ ++++ LL+ GA + + ++G +P M AA GH ++++L
Sbjct: 1153 VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDM 1212
Query: 104 KADMT--IVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAH 161
+D+ I N + C + + L+ A+V + G + A +
Sbjct: 1213 GSDINAQIETNRNTALTLACF---QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1269
Query: 162 DVKDVCLTFLEKGANPNAINSSTGR-TALMEASREGVVEIVRGILERGGEVNAFDNDRHH 220
+V L+KGA+ NA + R TAL A+ +G + ++ RG ++ + +
Sbjct: 1270 --AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNT 1327
Query: 221 AAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
A+ GG FD+++LL DV TPL A G +Y+ +
Sbjct: 1328 PLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 59.3 bits (142), Expect = 1e-08
Identities = 46/141 (32%), Positives = 64/141 (45%), Gaps = 4/141 (2%)
Query: 156 ACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFD 215
AC D DV V L++G + N ++ G + L A G E+ + +L V
Sbjct: 212 ACSDG-DVNAV-RKLLDEGRSVNE-HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 216 NDRHHAAHFAAK-GGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
N AA GG+ DI+KLL ++ DV S GNT L YA GGF D K + G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 275 CDLKWKNLDHKTPRAVAKEGG 295
+++ N + TP A G
Sbjct: 329 ANIEDHNENGHTPLMEAASAG 349
Score = 58.2 bits (139), Expect = 3e-08
Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 1/131 (0%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
T L ACA G +D+VK LL +GAN+ + TPL A AG ++ +L++ GA I+
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINT 366
Query: 587 ASIN-NSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKE 645
S + L A LD V++LL+ GA + + + H+A+ A + L+ +
Sbjct: 367 HSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
Query: 646 KLDNLPKPAEN 656
+ PA++
Sbjct: 427 SGAQVNMPADS 437
Score = 57.0 bits (136), Expect = 7e-08
Identities = 43/133 (32%), Positives = 67/133 (50%), Gaps = 2/133 (1%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL-WTP 561
GD+ +++K + G V+ ++ L AC++G ++ + LL ANV N TP
Sbjct: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L A G DIV+LL+ A +++ S +T L A +D VK LL+ GA + N
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
Query: 622 RKGHS-AMDVAKA 633
GH+ M+ A A
Sbjct: 336 ENGHTPLMEAASA 348
Score = 56.2 bits (134), Expect = 1e-07
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
Query: 522 DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESG 581
++ + T L ACA G+ ++V L+ + A + D +TPL A AG +VE+L++ G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 582 ALIDAAS-INNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRII 640
I+A S TPL+ A R + V LL GA + N ++ + +A + II
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 641 DLI 643
++
Sbjct: 1172 KIL 1174
Score = 54.7 bits (130), Expect = 3e-07
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 6/178 (3%)
Query: 40 INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
IN N +AL LA ++VS LLD A+ + + + G TP M AA G+ +
Sbjct: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
Query: 100 LAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACED 159
L AD+ I K HY+ + + GA ++ +G A
Sbjct: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
Query: 160 AHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDND 217
H DV ++ GA+ +A ++ T LM A R+G V++V+ +++ EVN F +D
Sbjct: 1336 GH--FDVVQLLVQAGADVDAADNRK-ITPLMSAFRKGHVKVVQYLVK---EVNQFPSD 1387
Score = 53.9 bits (128), Expect = 6e-07
Identities = 45/193 (23%), Positives = 90/193 (46%), Gaps = 7/193 (3%)
Query: 503 GDLASLKKAFESGIPVDMK-DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
G + ++K + G ++ + + T L AC G +VV LL++ ANV TP
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNS--TPLNRAIESCRLDTVKYLLDIGAKFQL 619
L A G ++ +L++ GA ++A + +S T L A + + L+ GA +
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 620 ENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEE 679
N+KG++ + +A + ++ L+ + ++ A+N+K+ TP + +K +
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADV-DAADNRKI---TPLMSAFRKGHVKVVQY 1376
Query: 680 LLSSIYGVPTTSE 692
L+ + P+ E
Sbjct: 1377 LVKEVNQFPSDIE 1389
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/164 (27%), Positives = 76/164 (46%), Gaps = 5/164 (3%)
Query: 529 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALI-DAA 587
L AC+ G+++ V+ LL++G +VN + L AC AG ++ ++L+ A + D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 588 SINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKL 647
+ + TPL A LD VK LL A ++ G++A+ A A I+ ++ +
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 648 DNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTS 691
N+ EN G TP + ++ LL G+ T S
Sbjct: 329 ANIEDHNEN----GHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/178 (27%), Positives = 75/178 (42%), Gaps = 14/178 (7%)
Query: 500 TKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLW 559
++ G L +K SG V T L AC +G+ DV LL+ GA++
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNS-TPLNRAIESCRLDTVKYLLDIGA--- 615
TPL A AG V+ L+ GA ++ A+ NN T ++ A L V+ LL GA
Sbjct: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
Query: 616 -------KFQLENRKGHSAMDVAKAYADY--RIIDLIKEKLDNLPKPAENQKLKGKTP 664
+E KG +V DY ++ + + LP P+++Q + P
Sbjct: 663 HRLKDGSTMLIEAAKG-GHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVP 719
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/110 (28%), Positives = 51/110 (46%), Gaps = 1/110 (0%)
Query: 188 ALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLI 247
+L EA +G V VR +L+ G VN + A G++++ ++L A + +V
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 248 SINGN-TPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGF 296
G+ TPL A+ GG+ D K + D+ ++ T A GGF
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
Score = 44.7 bits (104), Expect = 3e-04
Identities = 38/143 (26%), Positives = 62/143 (43%), Gaps = 3/143 (2%)
Query: 178 NAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLL 237
+A S TAL A G E+V ++ R ++ D AA G ++++L
Sbjct: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
Query: 238 FAYNGDVGLIS-INGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGF 296
GD+ S +TPL A GG + + RG + + +N+ TP ++A GG+
Sbjct: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167
Query: 297 KAASKEIRRAERIANKLARPGAK 319
K + A N +R G+K
Sbjct: 1168 VNIIKILLNAGAEIN--SRTGSK 1188
Score = 43.9 bits (102), Expect = 6e-04
Identities = 35/138 (25%), Positives = 55/138 (39%), Gaps = 14/138 (10%)
Query: 35 GYPELINY---------TEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPT 85
G+ EL+ Y G +AL A + D+ LL GA + + G TP
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
Query: 86 MRAAELGHELSMEILAK--AKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVN 143
M+AA GH +++ L A + +N+ V C H + L HGAD
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC---AGGHLAVVELLLAHGADPT 662
Query: 144 NSTYEGKPIFLRACEDAH 161
+ +G + + A + H
Sbjct: 663 HRLKDGSTMLIEAAKGGH 680
Score = 32.3 bits (72), Expect = 1.7
Identities = 15/50 (30%), Positives = 29/50 (58%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEK 547
+ + G ++ ++G VD DN TPLM+A G++ VV++L+++
Sbjct: 1331 LASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 31.2 bits (69), Expect = 3.8
Identities = 23/88 (26%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 210 EVNAFDNDRHHAA-HFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCK 268
+++A H A A GG +++ +L A + + G TPL AA G +
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 269 YIAQRGCDLKWKNLDHK-TPRAVAKEGG 295
+ +G D++ ++ K TP ++A GG
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGG 1133
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 80.5 bits (197), Expect = 6e-15
Identities = 75/263 (28%), Positives = 113/263 (42%), Gaps = 14/263 (5%)
Query: 28 IEKLTKLGYPELINYTE-PINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTM 86
+E+L K G +N + G +AL A D+V LL GA+P V P +
Sbjct: 87 VEELLKCG----VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPII 142
Query: 87 RAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNST 146
AA GH + +L + A + D G L + K H C L GADV+
Sbjct: 143 WAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAA--RKGHLECVKHLLAMGADVDQEG 200
Query: 147 YEGKPIFLRACEDAH--DVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGI 204
+ A + + VK++ L++ N N + G TALM AS+EG EIV+ +
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEI----LKRNPNVN-LTDKDGNTALMIASKEGHTEIVQDL 255
Query: 205 LERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFA 264
L+ G VN D A +GG +I++ L D+ + + T L++A G A
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 265 DCCKYIAQRGCDLKWKNLDHKTP 287
+ I Q D + D +TP
Sbjct: 316 TMVRDILQCNPDTEICTKDGETP 338
Score = 76.6 bits (187), Expect = 8e-14
Identities = 67/263 (25%), Positives = 117/263 (44%), Gaps = 7/263 (2%)
Query: 62 DMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYC 121
D+V LL GA + D+ G TP + AA GH ++ L AD VD EG +
Sbjct: 151 DIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD---VDQEGANSMTAL 207
Query: 122 ILPTKRHYRCALIA-LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAI 180
I+ K Y ++ L+ +VN + +G + A ++ H ++ L+ G N I
Sbjct: 208 IVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHT--EIVQDLLDAGTYVN-I 264
Query: 181 NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAY 240
+G T L+ A R G VEIVR +L++ +++ D A ++A + G +++ +
Sbjct: 265 PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQC 324
Query: 241 NGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAAS 300
N D + + +G TPL A + + + +G + + TP +A G + +
Sbjct: 325 NPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLA 384
Query: 301 KEIRRAERIANKLARPGAKNPNP 323
+ + R + L RP P
Sbjct: 385 ELLLRNPKDGRLLYRPNKAGETP 407
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/132 (33%), Positives = 71/132 (53%)
Query: 500 TKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLW 559
+K G + +++ + G+ ++ +D T LM AC G DVV+ LL GAN + T +
Sbjct: 79 SKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSV 138
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQL 619
P+ +A G DIV LL+++GA ++ + +TPL A L+ VK+LL +GA
Sbjct: 139 YPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQ 198
Query: 620 ENRKGHSAMDVA 631
E +A+ VA
Sbjct: 199 EGANSMTALIVA 210
Score = 64.3 bits (155), Expect = 4e-10
Identities = 63/221 (28%), Positives = 92/221 (41%), Gaps = 26/221 (11%)
Query: 504 DLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLH 563
++ +LK E VD ++ +TPLM A GN+++VK L++ GAN N D WT L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 564 FACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRK 623
A G IVE L++ G ++ + T L A R D V+ LL GA
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN------- 129
Query: 624 GHSAMDVAKAYADYRII--------DLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIK 675
V Y+ Y II D++ L N K + K G TP + ++
Sbjct: 130 ----PSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKY-GTTPLVWAARKGHLE 184
Query: 676 KEEELLSSIYGVPTTSEGKKVQKGNVVHLNSLITSGYTKKV 716
+ LL+ G EG +V + GYT+ V
Sbjct: 185 CVKHLLA--MGADVDQEGANSMTALIV----AVKGGYTQSV 219
Score = 64.3 bits (155), Expect = 4e-10
Identities = 39/127 (30%), Positives = 66/127 (51%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
I + G+L +K+ ++G +++D T L++A G++ +V+ LL+ G N+ D
Sbjct: 44 IAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMG 103
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
WT L +AC+ G+ D+VELL+ GA + + P+ A D V LL GAK
Sbjct: 104 GWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKV 163
Query: 618 QLENRKG 624
++ G
Sbjct: 164 NCSDKYG 170
Score = 63.5 bits (153), Expect = 7e-10
Identities = 59/228 (25%), Positives = 102/228 (44%), Gaps = 7/228 (3%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
G + L +A+ ++++V L+ GA+ +++D T + A++ GH +E L K ++
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 97
Query: 108 TIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVN-NSTYEGKPIFLRACEDAHDVKDV 166
D G L + K + L HGA+ + Y PI A D+
Sbjct: 98 EHRDMGGWTALMWACY--KGRTDVVELLLSHGANPSVTGLYSVYPIIWAA---GRGHADI 152
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L+ GA N + G T L+ A+R+G +E V+ +L G +V+ + A A
Sbjct: 153 VHLLLQNGAKVNC-SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAV 211
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
KGG+ +K + N +V L +GNT L A+ G + + + G
Sbjct: 212 KGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 259
Score = 62.0 bits (149), Expect = 2e-09
Identities = 65/258 (25%), Positives = 103/258 (39%), Gaps = 5/258 (1%)
Query: 60 DIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLF 119
+I + LL+ D ++ G TP M AAE G+ ++ L K A+ + D + L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 120 YCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNA 179
+ H L+ G ++ + G + AC DV L GANP+
Sbjct: 77 SA--SKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGR--TDVVELLLSHGANPSV 132
Query: 180 INSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFA 239
+ + A R G +IV +L+ G +VN D +AA+ G + +K L A
Sbjct: 133 TGLYSVYPIIWAAGR-GHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
Query: 240 YNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAA 299
DV N T L A GG+ K I +R ++ + D T +A + G
Sbjct: 192 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEI 251
Query: 300 SKEIRRAERIANKLARPG 317
+++ A N R G
Sbjct: 252 VQDLLDAGTYVNIPDRSG 269
Score = 61.6 bits (148), Expect = 3e-09
Identities = 49/196 (25%), Positives = 87/196 (44%), Gaps = 20/196 (10%)
Query: 524 YYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGAL 583
Y P++ A G+ D+V LL+ GA VN +D + TPL +A G + V+ L+ GA
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 584 IDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
+D N+ T L A++ +VK +L L ++ G++A+ +A +++
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGH---TEIV 252
Query: 644 KEKLD-----NLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTSEGKK--- 695
++ LD N+P + G T I G ++ LL + + K
Sbjct: 253 QDLLDAGTYVNIPDRS------GDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306
Query: 696 ---VQKGNVVHLNSLI 708
V+KGN + ++
Sbjct: 307 YWAVEKGNATMVRDIL 322
Score = 60.1 bits (144), Expect = 8e-09
Identities = 47/205 (22%), Positives = 99/205 (48%), Gaps = 20/205 (9%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
I +K G ++ ++G V++ D T L+ A G++++V+ LL+K A+++
Sbjct: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
T L++A G +V +++ + + + TPL +A + ++ V+ LLD GAK
Sbjct: 302 NKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKV 361
Query: 618 QLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKL-----KGKTPPILKTEGP 672
++KG + + +A ++ +L+ L P + + L G+TP +
Sbjct: 362 SAVDKKGDTPLHIAIRGRSRKLAELL------LRNPKDGRLLYRPNKAGETPYNI----- 410
Query: 673 EIKKEEELLSSIYGV----PTTSEG 693
+ ++ +L+ I+G PT ++G
Sbjct: 411 DCSHQKSILTQIFGARHLSPTETDG 435
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/184 (27%), Positives = 81/184 (44%), Gaps = 4/184 (2%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
+ K G S+K+ + V++ D T LM A G+ ++V+ LL+ G VN D
Sbjct: 209 VAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRS 268
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
T L A G +IV L++ A ID +N T L A+E V+ +L
Sbjct: 269 GDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDT 328
Query: 618 QLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKE 677
++ + G + + A + +++L+ LD K + K KG TP + G K
Sbjct: 329 EICTKDGETPLIKATKMRNIEVVELL---LDKGAKVSAVDK-KGDTPLHIAIRGRSRKLA 384
Query: 678 EELL 681
E LL
Sbjct: 385 ELLL 388
Score = 50.1 bits (118), Expect = 8e-06
Identities = 50/196 (25%), Positives = 84/196 (42%), Gaps = 8/196 (4%)
Query: 501 KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT 560
+ G L +K G VD + T L+ A G VK +L++ NVN TD T
Sbjct: 179 RKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNT 238
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
L A G +IV+ L+++G ++ + T L A+ ++ V+ LL A +
Sbjct: 239 ALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR 298
Query: 621 NRKGHSAMDVAKAYADYRII-DLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEE 679
+ +A+ A + ++ D+++ D E G+TP I T+ I+ E
Sbjct: 299 GQDNKTALYWAVEKGNATMVRDILQCNPD-----TEICTKDGETPLIKATKMRNIEVVEL 353
Query: 680 LLSSIYGVPTTSEGKK 695
LL G ++ KK
Sbjct: 354 LLDK--GAKVSAVDKK 367
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/146 (23%), Positives = 66/146 (45%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD 572
++G V+ D Y TPL+ A G+++ VK LL GA+V+ T L A G
Sbjct: 158 QNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQ 217
Query: 573 IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAK 632
V+ +++ ++ + +T L A + + V+ LLD G + +R G + + A
Sbjct: 218 SVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAV 277
Query: 633 AYADYRIIDLIKEKLDNLPKPAENQK 658
I+ + +K ++ ++ K
Sbjct: 278 RGGHVEIVRALLQKYADIDIRGQDNK 303
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 79.7 bits (195), Expect = 9e-15
Identities = 67/269 (24%), Positives = 113/269 (42%), Gaps = 7/269 (2%)
Query: 42 YTEPINGLSALHLASVSNDIDMVSFLLD--LGAHPDVQDRMGCTPTMRAAELGHELSMEI 99
+ E +GL+ LH A+ + +++F+++ D D++G T RAAE G +++
Sbjct: 118 HCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDF 177
Query: 100 LAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACED 159
L + D + D EG L + + H ++ G D+ EG A
Sbjct: 178 LVGSGCDHNVKDKEGNTALH--LAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGG 235
Query: 160 AHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRH 219
+H D L G+ NA+ + L A+ G ++ R ++ GG N D+
Sbjct: 236 SHP--DCVQLLLRAGSTVNALTQKN-LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA 292
Query: 220 HAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKW 279
H A + F +++LL + DV + TPLH AA + D + G DL
Sbjct: 293 SPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNL 352
Query: 280 KNLDHKTPRAVAKEGGFKAASKEIRRAER 308
++ KT AVA + I +A+R
Sbjct: 353 RDKQGKTALAVAVRSNHVSLVDMIIKADR 381
Score = 63.9 bits (154), Expect = 5e-10
Identities = 60/237 (25%), Positives = 93/237 (39%), Gaps = 6/237 (2%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
G +A H A+ +D + FL+ G +V+D+ G T AA GH ++ L D+
Sbjct: 159 GRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDL 218
Query: 108 TIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVC 167
+ EG L + H C + L G+ VN T + A + DV
Sbjct: 219 EEQNAEGLTALHSAAGGS--HPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSE--DVS 274
Query: 168 LTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAK 227
+ G N ++ G + L A R +VR ++ +VNA DN + H AA+
Sbjct: 275 RVLIHAGGCANVVDHQ-GASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAE 333
Query: 228 GGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
+ DI +L D+ L G T L A I + +W+ DH
Sbjct: 334 HAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEK-DH 389
Score = 54.7 bits (130), Expect = 3e-07
Identities = 34/112 (30%), Positives = 53/112 (47%)
Query: 532 ACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINN 591
A SG+ DV + L+ G N D+ +PLH A +V LL+ S + ++A
Sbjct: 265 AALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQ 324
Query: 592 STPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
TPL+ A E D LL G L +++G +A+ VA ++D+I
Sbjct: 325 QTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMI 376
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/116 (25%), Positives = 49/116 (42%)
Query: 516 IPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVE 575
+ +D D +T A G +D + FL+ G + N D T LH A G +++
Sbjct: 150 VALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQ 209
Query: 576 LLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVA 631
LV+ G ++ + T L+ A D V+ LL G+ +K S + A
Sbjct: 210 RLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYA 265
Score = 43.9 bits (102), Expect = 6e-04
Identities = 30/123 (24%), Positives = 56/123 (45%)
Query: 489 SEKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
++K S ++ +G + +G ++ D+ +PL A +V+ L+
Sbjct: 255 TQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSD 314
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
++VNA DN TPLH A QDI ++L+ +G ++ T L A+ S + V
Sbjct: 315 SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVD 374
Query: 609 YLL 611
++
Sbjct: 375 MII 377
Score = 40.4 bits (93), Expect = 0.006
Identities = 52/197 (26%), Positives = 76/197 (38%), Gaps = 9/197 (4%)
Query: 128 HYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVC----LTFLEKGANPNA---I 180
H + + LEH A V+ G R C + + L L+ N A
Sbjct: 60 HEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHC 119
Query: 181 NSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDR--HHAAHFAAKGGFFDILKLLF 238
S G T L A+++G V ++ I+E +V D+ A H AA+ G D L L
Sbjct: 120 ESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLV 179
Query: 239 AYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKA 298
D + GNT LH AA G + + G DL+ +N + T A G
Sbjct: 180 GSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPD 239
Query: 299 ASKEIRRAERIANKLAR 315
+ + RA N L +
Sbjct: 240 CVQLLLRAGSTVNALTQ 256
>gi|118150656 ankyrin repeat domain 7 [Homo sapiens]
Length = 254
Score = 79.3 bits (194), Expect = 1e-14
Identities = 55/186 (29%), Positives = 93/186 (50%), Gaps = 7/186 (3%)
Query: 490 EKVFSNINIITKAGDLASLKKAFE-SGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKG 548
EK ++ GDL LK+ + V+M+D Y+TPL ACA+G+ DVV FL+E+
Sbjct: 23 EKDLKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACANGHTDVVLFLIEQQ 82
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVK 608
+N D+ +PL A +D +L+ GA D I +T L+ A+ L V+
Sbjct: 83 CKINVRDSENKSPLIKAVQCQNEDCATILLNFGADPDLRDIRYNTVLHYAVCGQSLSLVE 142
Query: 609 YLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEK------LDNLPKPAENQKLKGK 662
LL+ A + +N+ G++ + VA + +++ + EK DN + A + G+
Sbjct: 143 KLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILAVSGE 202
Query: 663 TPPILK 668
P ++K
Sbjct: 203 PPCLVK 208
Score = 53.9 bits (128), Expect = 6e-07
Identities = 30/70 (42%), Positives = 43/70 (61%), Gaps = 2/70 (2%)
Query: 512 FESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQ 571
+E+ + KD Y TPL+ A + N +VKFLLEKGA+VNA+DN+ T L A
Sbjct: 147 YEADLEAKNKDGY--TPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILAVSGEPP 204
Query: 572 DIVELLVESG 581
+V+LL++ G
Sbjct: 205 CLVKLLLQQG 214
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/191 (26%), Positives = 84/191 (43%), Gaps = 8/191 (4%)
Query: 49 LSALHLASVSNDIDMVSFLLDLGAHP-DVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
L LH A+ D+ + L + + ++QD+ TP A GH + L + + +
Sbjct: 26 LKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACANGHTDVVLFLIEQQCKI 85
Query: 108 TIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRA-CEDAHDVKDV 166
+ D+E K L + ++ CA I L GAD + + A C + + +
Sbjct: 86 NVRDSENKSPLIKAV--QCQNEDCATILLNFGADPDLRDIRYNTVLHYAVCGQSLSLVE- 142
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
LE A+ A N G T L+ A ++V+ +LE+G +VNA DN + A A
Sbjct: 143 --KLLEYEADLEAKNKD-GYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILAV 199
Query: 227 KGGFFDILKLL 237
G ++KLL
Sbjct: 200 SGEPPCLVKLL 210
Score = 43.5 bits (101), Expect = 7e-04
Identities = 52/202 (25%), Positives = 90/202 (44%), Gaps = 15/202 (7%)
Query: 20 VRNKDKKQIEKLTKLG-------YPELINYTEPINGL---SALHLASVSNDIDMVSFLLD 69
+R KD K++ + +G Y ++ Y + + LHLA + D+V FL++
Sbjct: 21 LREKDLKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACANGHTDVVLFLIE 80
Query: 70 LGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHY 129
+V+D +P ++A + +E IL AD + D VL Y +
Sbjct: 81 QQCKINVRDSENKSPLIKAVQCQNEDCATILLNFGADPDLRDIRYNTVLHYAVCGQSLSL 140
Query: 130 RCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTAL 189
L LE+ AD+ +G L A ++ + LEKGA+ NA + + RTAL
Sbjct: 141 VEKL--LEYEADLEAKNKDGYTPLLVAV--INNNPKMVKFLLEKGADVNA-SDNYQRTAL 195
Query: 190 MEASREGVVEIVRGILERGGEV 211
+ A +V+ +L++G E+
Sbjct: 196 ILAVSGEPPCLVKLLLQQGVEL 217
Score = 43.5 bits (101), Expect = 7e-04
Identities = 31/106 (29%), Positives = 47/106 (44%)
Query: 186 RTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVG 245
RT L A G ++V ++E+ ++N D++ A + D +L + D
Sbjct: 60 RTPLHLACANGHTDVVLFLIEQQCKINVRDSENKSPLIKAVQCQNEDCATILLNFGADPD 119
Query: 246 LISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVA 291
L I NT LHYA G + + + DL+ KN D TP VA
Sbjct: 120 LRDIRYNTVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVA 165
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/106 (30%), Positives = 50/106 (47%)
Query: 515 GIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIV 574
G D++D Y T L A ++ +V+ LLE A++ A + +TPL A +V
Sbjct: 115 GADPDLRDIRYNTVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMV 174
Query: 575 ELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
+ L+E GA ++A+ T L A+ VK LL G + E
Sbjct: 175 KFLLEKGADVNASDNYQRTALILAVSGEPPCLVKLLLQQGVELCYE 220
Score = 40.0 bits (92), Expect = 0.008
Identities = 34/154 (22%), Positives = 66/154 (42%), Gaps = 3/154 (1%)
Query: 141 DVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEI 200
DVN + + AC + H DV L +E+ N + S ++ L++A + +
Sbjct: 51 DVNMQDKKYRTPLHLACANGHT--DVVLFLIEQQCKIN-VRDSENKSPLIKAVQCQNEDC 107
Query: 201 VRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAM 260
+L G + + D + H+A G +++ L Y D+ + +G TPL A +
Sbjct: 108 ATILLNFGADPDLRDIRYNTVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVI 167
Query: 261 GGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEG 294
K++ ++G D+ + +T +A G
Sbjct: 168 NNNPKMVKFLLEKGADVNASDNYQRTALILAVSG 201
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 79.3 bits (194), Expect = 1e-14
Identities = 43/128 (33%), Positives = 67/128 (52%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
G LA ++K E+G ++ +D T + A GN+DV+K LL KGA ++A D L T L
Sbjct: 164 GHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTAL 223
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENR 622
H A G + E L+ A ++A TPL+ A+ R ++ L+ GA ++N
Sbjct: 224 HVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNC 283
Query: 623 KGHSAMDV 630
G + MD+
Sbjct: 284 AGKTPMDL 291
Score = 70.1 bits (170), Expect = 7e-12
Identities = 47/158 (29%), Positives = 81/158 (51%), Gaps = 12/158 (7%)
Query: 498 IITKAGDLAS-LKKAFESGIPV-----------DMKDNYYKTPLMTACASGNIDVVKFLL 545
IIT+ D+ + LK A E+ +PV D+ D Y +T L AC G++ +V+ L+
Sbjct: 114 IITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLM 173
Query: 546 EKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLD 605
E GA + D T +H+A G D+++LL+ GA I A ST L+ A+ + +
Sbjct: 174 EAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYE 233
Query: 606 TVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLI 643
++L+ A ++R+G + + A Y++I L+
Sbjct: 234 CAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLL 271
Score = 57.8 bits (138), Expect = 4e-08
Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 3/137 (2%)
Query: 151 PIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGE 210
P FL+A + + V FL NP+ + RTAL A EG + IV ++E G +
Sbjct: 122 PTFLKAALE--NKLPVVEKFLSDKNNPDVCDEYK-RTALHRACLEGHLAIVEKLMEAGAQ 178
Query: 211 VNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYI 270
+ D A H+A++GG D+LKLL + +T LH A G +C +++
Sbjct: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
Query: 271 AQRGCDLKWKNLDHKTP 287
DL K+ + TP
Sbjct: 239 IACEADLNAKDREGDTP 255
Score = 53.9 bits (128), Expect = 6e-07
Identities = 43/162 (26%), Positives = 71/162 (43%), Gaps = 5/162 (3%)
Query: 155 RACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAF 214
RAC + H + +E GA TA+ ASR G +++++ +L +G +++A
Sbjct: 159 RACLEGHLA--IVEKLMEAGAQIE-FRDMLESTAIHWASRGGNLDVLKLLLNKGAKISAR 215
Query: 215 DNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRG 274
D A H A + G ++ + L A D+ G+TPLH A + + G
Sbjct: 216 DKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG 275
Query: 275 CDLKWKNLDHKTPRAVAK--EGGFKAASKEIRRAERIANKLA 314
DL KN KTP + + G KA +R +++A
Sbjct: 276 ADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIA 317
Score = 48.9 bits (115), Expect = 2e-05
Identities = 59/249 (23%), Positives = 101/249 (40%), Gaps = 39/249 (15%)
Query: 7 RLENLQIYKVLQCVRNKDKKQIEKLTKLGYPELINYTEPINGLSALHLASVSNDIDMVSF 66
+LENL+ +++ ++ + K + K+ + PE TEP++ + L A++ N + +V
Sbjct: 80 KLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLK-AALENKLPVVEK 138
Query: 67 LLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVDNEGKGVLFYCILPTK 126
L +PDV D T RA GH +E L +A A + D + T
Sbjct: 139 FLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD---------MLESTA 189
Query: 127 RHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGR 186
H+ G ++ DV L KGA +A +
Sbjct: 190 IHW------ASRGGNL----------------------DVLKLLLNKGAKISARDKLLS- 220
Query: 187 TALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGL 246
TAL A R G E ++ ++NA D + H A + + +++LL Y D+ +
Sbjct: 221 TALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNI 280
Query: 247 ISINGNTPL 255
+ G TP+
Sbjct: 281 KNCAGKTPM 289
Score = 37.4 bits (85), Expect = 0.054
Identities = 30/145 (20%), Positives = 53/145 (36%)
Query: 173 KGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFD 232
K P I ++A+ E + +V L + D + A H A G
Sbjct: 108 KEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLA 167
Query: 233 ILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAK 292
I++ L + + +T +H+A+ GG D K + +G + ++ T VA
Sbjct: 168 IVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAV 227
Query: 293 EGGFKAASKEIRRAERIANKLARPG 317
G ++ + E N R G
Sbjct: 228 RTGHYECAEHLIACEADLNAKDREG 252
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 79.0 bits (193), Expect = 2e-14
Identities = 70/251 (27%), Positives = 110/251 (43%), Gaps = 10/251 (3%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRM---GCTPTMRAAELGHELSMEILAKAK 104
G S L LA + ++ LL + H +V+DR TP M AA GH +++L K
Sbjct: 267 GESLLCLACSAGYYELAQVLLAM--HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHK 324
Query: 105 ADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVK 164
AD+ + G L Y + + LE GA + + G + A H
Sbjct: 325 ADVNAQSSTGNTALTYAC--AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGH--V 380
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
+V LE GA N ++ +AL A +G +E+VR +LE G + ++ H A
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
A G ++ +LL V + + + +PL AA GG + + +RG L+ N +
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
Query: 285 KTP-RAVAKEG 294
TP A+EG
Sbjct: 501 YTPLMEAAREG 511
Score = 77.8 bits (190), Expect = 4e-14
Identities = 69/247 (27%), Positives = 107/247 (43%), Gaps = 6/247 (2%)
Query: 52 LHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVD 111
L LA ++V LL GA+ + ++ TP AA G+ ++IL A A++
Sbjct: 1154 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1213
Query: 112 NEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLR-ACEDAHDVKDVCLTF 170
G+ + H + L+ G+D+N + L AC +V
Sbjct: 1214 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT--EVVSLL 1271
Query: 171 LEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNA--FDNDRHHAAHFAAKG 228
L++ AN + TG T LMEA+ G E+ R +L++G +VNA + R A AA
Sbjct: 1272 LDRKANVEH-RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330
Query: 229 GFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPR 288
G + +LL + + + GNTPL AA GG D + + Q G D+ + TP
Sbjct: 1331 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
Query: 289 AVAKEGG 295
A G
Sbjct: 1391 MAAFRKG 1397
Score = 75.1 bits (183), Expect = 2e-13
Identities = 71/252 (28%), Positives = 105/252 (41%), Gaps = 35/252 (13%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
S L LA+ +++ + L++ GA + + G TP M AA GHE + +L A++
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 110 VDNE------------------------GKGVLFYCILPTKR-----HYRCALIALEHGA 140
E G + C P H L GA
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGA 588
Query: 141 DVNNSTYEGKPIFLRACEDAH-DVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVE 199
+V+ +T G ACE+ H DV DV L+ GA+ S GRT LM+A+R G V
Sbjct: 589 NVHATTATGDTALTYACENGHTDVADV---LLQAGADLEH-ESEGGRTPLMKAARAGHVC 644
Query: 200 IVRGILERGGEVNAFD-NDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYA 258
V+ ++ +G VN N+ H A GG +++LL A+ D +G+T L A
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 259 AMGGFADCCKYI 270
A GG Y+
Sbjct: 705 AKGGHTSVVCYL 716
Score = 73.2 bits (178), Expect = 9e-13
Identities = 73/281 (25%), Positives = 114/281 (40%), Gaps = 37/281 (13%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
SAL LA ++MV FLL+ GA + + T M A GH +L + A + +
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLT 169
+ + L + H A + +E GA + EG + A + H+ ++
Sbjct: 463 PADSFESPL--TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE--EMVAL 518
Query: 170 FLEKGANPNAINSSTGRTAL------------------------------MEASREGVVE 199
L +GAN NA T TAL MEA++EG +E
Sbjct: 519 LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLE 578
Query: 200 IVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAA 259
+V+ +L G V+A A +A + G D+ +L D+ S G TPL AA
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
Query: 260 MGGFADCCKYIAQRGCDLK--WKNLDHKTPRAVAKEGGFKA 298
G +++ +G ++ N DH T ++A GG A
Sbjct: 639 RAGHVCTVQFLISKGANVNRTTANNDH-TVLSLACAGGHLA 678
Score = 70.5 bits (171), Expect = 6e-12
Identities = 39/118 (33%), Positives = 68/118 (57%), Gaps = 1/118 (0%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A G++++VK+LL GANV+AT T L +AC G D+ ++L+++GA ++
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKF-QLENRKGHSAMDVAKAYADYRIIDLI 643
S TPL +A + + TV++L+ GA + H+ + +A A +++L+
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL 683
Score = 70.5 bits (171), Expect = 6e-12
Identities = 82/322 (25%), Positives = 134/322 (41%), Gaps = 14/322 (4%)
Query: 36 YPEL-INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHE 94
YP + I+ N +AL LA ++V LL+ GA + +D+ G TP + AA GH
Sbjct: 1070 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 1129
Query: 95 LSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFL 154
+EIL AD+ K R L+ + + + P+ L
Sbjct: 1130 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Query: 155 RACEDAHDVKDVCLTFLEKGANPNA-INSSTGRTALMEASREGVVEIVRGILERGGEVNA 213
A + ++ L GA N+ S G + LM A+ G V+ +L+ G ++NA
Sbjct: 1190 AA---SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 1246
Query: 214 -FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ +R+ A A G +++ LL +V + G TPL AA GG+A+ + +
Sbjct: 1247 QIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1306
Query: 273 RGCDLKWKNLDHKTPRAV---AKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
+G D+ + A+ A +G +K I R I + K PLW L
Sbjct: 1307 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR----NKKGNTPLW-LAA 1361
Query: 330 HDWSVEREAFLREAFAVLDRGD 351
+ ++ L +A A +D D
Sbjct: 1362 NGGHLDVVQLLVQAGADVDAAD 1383
Score = 69.7 bits (169), Expect = 1e-11
Identities = 39/113 (34%), Positives = 69/113 (61%), Gaps = 3/113 (2%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA-TDNFLWTPLHFACHAGQQ 571
E G ++ +D TPL+ A +G++ VV+ LL+ GA++ A ++ TPL AC G+Q
Sbjct: 1104 ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQ 1163
Query: 572 DIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKG 624
++VELL+ GA + ++++ TPL+ A ++ +K LL+ GA ++ +R G
Sbjct: 1164 EVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA--EINSRTG 1214
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/123 (33%), Positives = 69/123 (56%), Gaps = 1/123 (0%)
Query: 522 DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESG 581
++ + T L ACA G+ ++V+ LLE+GA++ D +TPL A AG +VE+L+++G
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
Query: 582 ALIDAAS-INNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRII 640
A I+A S TPL+ A R + V+ LL GA + N ++ + +A + II
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
Query: 641 DLI 643
++
Sbjct: 1200 KIL 1202
Score = 64.3 bits (155), Expect = 4e-10
Identities = 36/89 (40%), Positives = 53/89 (59%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A G++ +VK LL A+VNA + T L +AC G D+V++L+ESGA I+
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ N TPL A + ++ + LL+ GA
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGA 391
Score = 62.4 bits (150), Expect = 2e-09
Identities = 37/130 (28%), Positives = 60/130 (46%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
S + + G L ++ E+G + K + T LM AC G+++V + LL+ GA VN
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+ +PL A G ++ LL+E GA ++ + TPL A + V LL
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 614 GAKFQLENRK 623
GA + +
Sbjct: 523 GANINAQTEE 532
Score = 62.0 bits (149), Expect = 2e-09
Identities = 40/140 (28%), Positives = 69/140 (49%), Gaps = 1/140 (0%)
Query: 508 LKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDN-FLWTPLHFAC 566
+K ESG ++ + TPLM A ++G+++V + LLE GA +N N F + L AC
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC 409
Query: 567 HAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHS 626
+ G ++V L+E+GA + + T L A ++ + LLD GA+ + S
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
Query: 627 AMDVAKAYADYRIIDLIKEK 646
+ +A + L+ E+
Sbjct: 470 PLTLAACGGHVELAALLIER 489
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/180 (27%), Positives = 93/180 (51%), Gaps = 10/180 (5%)
Query: 490 EKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYK-TPLMTACASGNIDVVKFLLEKG 548
+K F+ + + AG + ++ ++G ++ + K TPL AC+ G +VV+ LL +G
Sbjct: 1114 KKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARG 1173
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA--ASINNSTPLNRAIESCRLDT 606
AN + +TPL A G +I+++L+ +GA I++ S +PL A +
Sbjct: 1174 ANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAA 1233
Query: 607 VKYLLDIGAKF--QLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
VK LLD+G+ Q+E + ++A+ +A ++ L+ ++ N+ E++ G TP
Sbjct: 1234 VKLLLDMGSDINAQIETNR-NTALTLACFQGRTEVVSLLLDRKANV----EHRAKTGLTP 1288
Score = 60.5 bits (145), Expect = 6e-09
Identities = 35/128 (27%), Positives = 68/128 (53%), Gaps = 1/128 (0%)
Query: 502 AGDLASLKKAFESGIPVDMKDNYYKTPLMT-ACASGNIDVVKFLLEKGANVNATDNFLWT 560
AG + + E+G ++ N +K +T AC G++++V+FLLE GA+ + + T
Sbjct: 377 AGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHT 436
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
L AC G ++ LL++SGA ++ + + +PL A ++ L++ GA +
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496
Query: 621 NRKGHSAM 628
N +G++ +
Sbjct: 497 NDEGYTPL 504
Score = 59.3 bits (142), Expect = 1e-08
Identities = 43/140 (30%), Positives = 71/140 (50%), Gaps = 1/140 (0%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V+ + + T L ACA G +DVVK LLE GA++ + TPL A AG ++ LL
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Query: 578 VESGALIDAASIN-NSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYAD 636
+E+GA I+ S + L A L+ V++LL+ GA + + + H+A+ A
Sbjct: 387 LENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446
Query: 637 YRIIDLIKEKLDNLPKPAEN 656
+ L+ + + PA++
Sbjct: 447 VEVARLLLDSGAQVNMPADS 466
Score = 59.3 bits (142), Expect = 1e-08
Identities = 54/232 (23%), Positives = 101/232 (43%), Gaps = 10/232 (4%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQ--DRMGCTPTMRAAELGHELSMEILAKA 103
++ + L LA+ ++++ LL+ GA + + ++G +P M AA GH ++++L
Sbjct: 1181 VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM 1240
Query: 104 KADMT--IVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAH 161
+D+ I N + C + + L+ A+V + G + A +
Sbjct: 1241 GSDINAQIETNRNTALTLACF---QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1297
Query: 162 DVKDVCLTFLEKGANPNAINSSTGR-TALMEASREGVVEIVRGILERGGEVNAFDNDRHH 220
+V L+KGA+ NA + R TAL A+ +G + ++ RG ++ + +
Sbjct: 1298 --AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1355
Query: 221 AAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
AA GG D+++LL DV TPL A G +Y+ +
Sbjct: 1356 PLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 58.5 bits (140), Expect = 2e-08
Identities = 40/150 (26%), Positives = 67/150 (44%), Gaps = 2/150 (1%)
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
L G VN T EG+ + AC + ++ L AN T LM A+
Sbjct: 254 LIEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANVEDRGIKGDITPLMAAANG 311
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G V+IV+ +L +VNA + + A +A GG+ D++K+L + + NG+TPL
Sbjct: 312 GHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPL 371
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
A G + + + + G + + + K
Sbjct: 372 MEAGSAGHVEVARLLLENGAGINTHSNEFK 401
Score = 55.5 bits (132), Expect = 2e-07
Identities = 43/146 (29%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL---W 559
GD+ +++K G V+ ++ L AC++G ++ + LL ANV D +
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE--DRGIKGDI 302
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQL 619
TPL A + G IV+LL+ A ++A S +T L A +D VK LL+ GA +
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 620 ENRKGHSAMDVAKAYADYRIIDLIKE 645
N GH+ + A + + L+ E
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLE 388
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/193 (24%), Positives = 89/193 (46%), Gaps = 7/193 (3%)
Query: 503 GDLASLKKAFESGIPVDMK-DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
G A++K + G ++ + + T L AC G +VV LL++ ANV TP
Sbjct: 1229 GHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTP 1288
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNS--TPLNRAIESCRLDTVKYLLDIGAKFQL 619
L A G ++ +L++ GA ++A + +S T L A + + L+ GA +
Sbjct: 1289 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1348
Query: 620 ENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEE 679
N+KG++ + +A ++ L+ + ++ A+N+K+ TP + +K
Sbjct: 1349 RNKKGNTPLWLAANGGHLDVVQLLVQAGADV-DAADNRKI---TPLMAAFRKGHVKVVRY 1404
Query: 680 LLSSIYGVPTTSE 692
L+ + P+ SE
Sbjct: 1405 LVKEVNQFPSDSE 1417
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/131 (26%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 526 KTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALID 585
+T L AC G ++V FL++ GA++ + TPL A G ++V+ L+ +GA +
Sbjct: 535 ETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVH 591
Query: 586 AASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKE 645
A + T L A E+ D LL GA + E+ G + + A + +
Sbjct: 592 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 646 KLDNLPKPAEN 656
K N+ + N
Sbjct: 652 KGANVNRTTAN 662
Score = 51.6 bits (122), Expect = 3e-06
Identities = 28/71 (39%), Positives = 36/71 (50%)
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
AA GG I+KLL A+ DV S GNT L YA GG+ D K + + G ++ N +
Sbjct: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367
Query: 285 KTPRAVAKEGG 295
TP A G
Sbjct: 368 HTPLMEAGSAG 378
Score = 47.4 bits (111), Expect = 5e-05
Identities = 43/164 (26%), Positives = 75/164 (45%), Gaps = 5/164 (3%)
Query: 529 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAAS 588
L AC+ G+++ V+ LL +G +VN + L AC AG ++ ++L+ A ++
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 589 INNS-TPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKL 647
I TPL A + VK LL A ++ G++A+ A A +D++K L
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG---YVDVVKVLL 354
Query: 648 DNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTS 691
++ E+ G TP + ++ LL + G+ T S
Sbjct: 355 ES-GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397
Score = 47.0 bits (110), Expect = 7e-05
Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 1/114 (0%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
G L +K +G V T L AC +G+ DV LL+ GA++ TPL
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNS-TPLNRAIESCRLDTVKYLLDIGA 615
A AG V+ L+ GA ++ + NN T L+ A L V+ LL GA
Sbjct: 635 MKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Score = 46.6 bits (109), Expect = 9e-05
Identities = 39/138 (28%), Positives = 58/138 (42%), Gaps = 3/138 (2%)
Query: 160 AHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRH 219
A D LT + + NA S +L EA EG V VR +L G VN +
Sbjct: 211 ALDEAAAALTRMRAESTANAGQSDN--RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGE 268
Query: 220 HAAHFAAKGGFFDILKLLFAYNGDVGLISINGN-TPLHYAAMGGFADCCKYIAQRGCDLK 278
A G++++ ++L A + +V I G+ TPL AA GG K + D+
Sbjct: 269 SLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVN 328
Query: 279 WKNLDHKTPRAVAKEGGF 296
++ T A GG+
Sbjct: 329 AQSSTGNTALTYACAGGY 346
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 56/138 (40%), Gaps = 14/138 (10%)
Query: 35 GYPELINY---------TEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPT 85
G+ EL+ Y G +AL A + D+ LL GA + + G TP
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634
Query: 86 MRAAELGHELSMEILAK--AKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVN 143
M+AA GH +++ L A + T +N+ + C H + L HGAD
Sbjct: 635 MKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC---AGGHLAVVELLLAHGADPT 691
Query: 144 NSTYEGKPIFLRACEDAH 161
+ +G + + A + H
Sbjct: 692 HRLKDGSTMLIEAAKGGH 709
Score = 35.0 bits (79), Expect = 0.27
Identities = 50/217 (23%), Positives = 85/217 (39%), Gaps = 17/217 (7%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDN- 556
+ G L ++ ++G VD DN TPLM A G++ VV++L+ K N +D+
Sbjct: 1359 LAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV-KEVNQFPSDSE 1417
Query: 557 ---FLWT----PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKY 609
++ T + CH + IV+ A + N++ L ++ +L
Sbjct: 1418 CMRYIATITDKEMLKKCHLCMESIVQAKDRQA----AEANKNASILLEELDLEKLREESR 1473
Query: 610 LLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKT 669
L + AK E RK + I+ ++ L E +KLK + P + T
Sbjct: 1474 RLALAAK--REKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLT 1531
Query: 670 EGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNS 706
E P + I TT G ++ N + S
Sbjct: 1532 EPPSATTTTTI--GISATWTTLAGSHGKRNNTITTTS 1566
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 79.0 bits (193), Expect = 2e-14
Identities = 70/251 (27%), Positives = 110/251 (43%), Gaps = 10/251 (3%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRM---GCTPTMRAAELGHELSMEILAKAK 104
G S L LA + ++ LL + H +V+DR TP M AA GH +++L K
Sbjct: 267 GESLLCLACSAGYYELAQVLLAM--HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHK 324
Query: 105 ADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVK 164
AD+ + G L Y + + LE GA + + G + A H
Sbjct: 325 ADVNAQSSTGNTALTYAC--AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGH--V 380
Query: 165 DVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHF 224
+V LE GA N ++ +AL A +G +E+VR +LE G + ++ H A
Sbjct: 381 EVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALME 440
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
A G ++ +LL V + + + +PL AA GG + + +RG L+ N +
Sbjct: 441 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEG 500
Query: 285 KTP-RAVAKEG 294
TP A+EG
Sbjct: 501 YTPLMEAAREG 511
Score = 77.8 bits (190), Expect = 4e-14
Identities = 69/247 (27%), Positives = 107/247 (43%), Gaps = 6/247 (2%)
Query: 52 LHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIVD 111
L LA ++V LL GA+ + ++ TP AA G+ ++IL A A++
Sbjct: 903 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962
Query: 112 NEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLR-ACEDAHDVKDVCLTF 170
G+ + H + L+ G+D+N + L AC +V
Sbjct: 963 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT--EVVSLL 1020
Query: 171 LEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNA--FDNDRHHAAHFAAKG 228
L++ AN + TG T LMEA+ G E+ R +L++G +VNA + R A AA
Sbjct: 1021 LDRKANVEH-RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1079
Query: 229 GFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPR 288
G + +LL + + + GNTPL AA GG D + + Q G D+ + TP
Sbjct: 1080 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1139
Query: 289 AVAKEGG 295
A G
Sbjct: 1140 MAAFRKG 1146
Score = 75.1 bits (183), Expect = 2e-13
Identities = 71/252 (28%), Positives = 105/252 (41%), Gaps = 35/252 (13%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
S L LA+ +++ + L++ GA + + G TP M AA GHE + +L A++
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 110 VDNE------------------------GKGVLFYCILPTKR-----HYRCALIALEHGA 140
E G + C P H L GA
Sbjct: 529 QTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGA 588
Query: 141 DVNNSTYEGKPIFLRACEDAH-DVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVE 199
+V+ +T G ACE+ H DV DV L+ GA+ S GRT LM+A+R G V
Sbjct: 589 NVHATTATGDTALTYACENGHTDVADV---LLQAGADLEH-ESEGGRTPLMKAARAGHVC 644
Query: 200 IVRGILERGGEVNAFD-NDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYA 258
V+ ++ +G VN N+ H A GG +++LL A+ D +G+T L A
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 259 AMGGFADCCKYI 270
A GG Y+
Sbjct: 705 AKGGHTSVVCYL 716
Score = 73.2 bits (178), Expect = 9e-13
Identities = 73/281 (25%), Positives = 114/281 (40%), Gaps = 37/281 (13%)
Query: 50 SALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTI 109
SAL LA ++MV FLL+ GA + + T M A GH +L + A + +
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 110 VDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLT 169
+ + L + H A + +E GA + EG + A + H+ ++
Sbjct: 463 PADSFESPL--TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHE--EMVAL 518
Query: 170 FLEKGANPNAINSSTGRTAL------------------------------MEASREGVVE 199
L +GAN NA T TAL MEA++EG +E
Sbjct: 519 LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLE 578
Query: 200 IVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAA 259
+V+ +L G V+A A +A + G D+ +L D+ S G TPL AA
Sbjct: 579 LVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 638
Query: 260 MGGFADCCKYIAQRGCDLK--WKNLDHKTPRAVAKEGGFKA 298
G +++ +G ++ N DH T ++A GG A
Sbjct: 639 RAGHVCTVQFLISKGANVNRTTANNDH-TVLSLACAGGHLA 678
Score = 70.5 bits (171), Expect = 6e-12
Identities = 39/118 (33%), Positives = 68/118 (57%), Gaps = 1/118 (0%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A G++++VK+LL GANV+AT T L +AC G D+ ++L+++GA ++
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKF-QLENRKGHSAMDVAKAYADYRIIDLI 643
S TPL +A + + TV++L+ GA + H+ + +A A +++L+
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELL 683
Score = 70.5 bits (171), Expect = 6e-12
Identities = 82/322 (25%), Positives = 134/322 (41%), Gaps = 14/322 (4%)
Query: 36 YPEL-INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHE 94
YP + I+ N +AL LA ++V LL+ GA + +D+ G TP + AA GH
Sbjct: 819 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 878
Query: 95 LSMEILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFL 154
+EIL AD+ K R L+ + + + P+ L
Sbjct: 879 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
Query: 155 RACEDAHDVKDVCLTFLEKGANPNA-INSSTGRTALMEASREGVVEIVRGILERGGEVNA 213
A + ++ L GA N+ S G + LM A+ G V+ +L+ G ++NA
Sbjct: 939 AA---SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 995
Query: 214 -FDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
+ +R+ A A G +++ LL +V + G TPL AA GG+A+ + +
Sbjct: 996 QIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1055
Query: 273 RGCDLKWKNLDHKTPRAV---AKEGGFKAASKEIRRAERIANKLARPGAKNPNPLWALRL 329
+G D+ + A+ A +G +K I R I + K PLW L
Sbjct: 1056 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR----NKKGNTPLW-LAA 1110
Query: 330 HDWSVEREAFLREAFAVLDRGD 351
+ ++ L +A A +D D
Sbjct: 1111 NGGHLDVVQLLVQAGADVDAAD 1132
Score = 69.7 bits (169), Expect = 1e-11
Identities = 39/113 (34%), Positives = 69/113 (61%), Gaps = 3/113 (2%)
Query: 513 ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA-TDNFLWTPLHFACHAGQQ 571
E G ++ +D TPL+ A +G++ VV+ LL+ GA++ A ++ TPL AC G+Q
Sbjct: 853 ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQ 912
Query: 572 DIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKG 624
++VELL+ GA + ++++ TPL+ A ++ +K LL+ GA ++ +R G
Sbjct: 913 EVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGA--EINSRTG 963
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/123 (33%), Positives = 69/123 (56%), Gaps = 1/123 (0%)
Query: 522 DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESG 581
++ + T L ACA G+ ++V+ LLE+GA++ D +TPL A AG +VE+L+++G
Sbjct: 829 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 888
Query: 582 ALIDAAS-INNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRII 640
A I+A S TPL+ A R + V+ LL GA + N ++ + +A + II
Sbjct: 889 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 948
Query: 641 DLI 643
++
Sbjct: 949 KIL 951
Score = 64.3 bits (155), Expect = 4e-10
Identities = 36/89 (40%), Positives = 53/89 (59%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
TPLM A G++ +VK LL A+VNA + T L +AC G D+V++L+ESGA I+
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGA 615
+ N TPL A + ++ + LL+ GA
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGA 391
Score = 62.4 bits (150), Expect = 2e-09
Identities = 37/130 (28%), Positives = 60/130 (46%)
Query: 494 SNINIITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNA 553
S + + G L ++ E+G + K + T LM AC G+++V + LL+ GA VN
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 554 TDNFLWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDI 613
+ +PL A G ++ LL+E GA ++ + TPL A + V LL
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 614 GAKFQLENRK 623
GA + +
Sbjct: 523 GANINAQTEE 532
Score = 62.0 bits (149), Expect = 2e-09
Identities = 40/140 (28%), Positives = 69/140 (49%), Gaps = 1/140 (0%)
Query: 508 LKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDN-FLWTPLHFAC 566
+K ESG ++ + TPLM A ++G+++V + LLE GA +N N F + L AC
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLAC 409
Query: 567 HAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHS 626
+ G ++V L+E+GA + + T L A ++ + LLD GA+ + S
Sbjct: 410 YKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
Query: 627 AMDVAKAYADYRIIDLIKEK 646
+ +A + L+ E+
Sbjct: 470 PLTLAACGGHVELAALLIER 489
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/180 (27%), Positives = 93/180 (51%), Gaps = 10/180 (5%)
Query: 490 EKVFSNINIITKAGDLASLKKAFESGIPVDMKDNYYK-TPLMTACASGNIDVVKFLLEKG 548
+K F+ + + AG + ++ ++G ++ + K TPL AC+ G +VV+ LL +G
Sbjct: 863 KKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARG 922
Query: 549 ANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA--ASINNSTPLNRAIESCRLDT 606
AN + +TPL A G +I+++L+ +GA I++ S +PL A +
Sbjct: 923 ANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAA 982
Query: 607 VKYLLDIGAKF--QLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTP 664
VK LLD+G+ Q+E + ++A+ +A ++ L+ ++ N+ E++ G TP
Sbjct: 983 VKLLLDMGSDINAQIETNR-NTALTLACFQGRTEVVSLLLDRKANV----EHRAKTGLTP 1037
Score = 60.5 bits (145), Expect = 6e-09
Identities = 35/128 (27%), Positives = 68/128 (53%), Gaps = 1/128 (0%)
Query: 502 AGDLASLKKAFESGIPVDMKDNYYKTPLMT-ACASGNIDVVKFLLEKGANVNATDNFLWT 560
AG + + E+G ++ N +K +T AC G++++V+FLLE GA+ + + T
Sbjct: 377 AGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHT 436
Query: 561 PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLE 620
L AC G ++ LL++SGA ++ + + +PL A ++ L++ GA +
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496
Query: 621 NRKGHSAM 628
N +G++ +
Sbjct: 497 NDEGYTPL 504
Score = 59.3 bits (142), Expect = 1e-08
Identities = 43/140 (30%), Positives = 71/140 (50%), Gaps = 1/140 (0%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V+ + + T L ACA G +DVVK LLE GA++ + TPL A AG ++ LL
Sbjct: 327 VNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Query: 578 VESGALIDAASIN-NSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYAD 636
+E+GA I+ S + L A L+ V++LL+ GA + + + H+A+ A
Sbjct: 387 LENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH 446
Query: 637 YRIIDLIKEKLDNLPKPAEN 656
+ L+ + + PA++
Sbjct: 447 VEVARLLLDSGAQVNMPADS 466
Score = 59.3 bits (142), Expect = 1e-08
Identities = 54/232 (23%), Positives = 101/232 (43%), Gaps = 10/232 (4%)
Query: 46 INGLSALHLASVSNDIDMVSFLLDLGAHPDVQ--DRMGCTPTMRAAELGHELSMEILAKA 103
++ + L LA+ ++++ LL+ GA + + ++G +P M AA GH ++++L
Sbjct: 930 VSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDM 989
Query: 104 KADMT--IVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAH 161
+D+ I N + C + + L+ A+V + G + A +
Sbjct: 990 GSDINAQIETNRNTALTLACF---QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1046
Query: 162 DVKDVCLTFLEKGANPNAINSSTGR-TALMEASREGVVEIVRGILERGGEVNAFDNDRHH 220
+V L+KGA+ NA + R TAL A+ +G + ++ RG ++ + +
Sbjct: 1047 --AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1104
Query: 221 AAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQ 272
AA GG D+++LL DV TPL A G +Y+ +
Sbjct: 1105 PLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 58.5 bits (140), Expect = 2e-08
Identities = 40/150 (26%), Positives = 67/150 (44%), Gaps = 2/150 (1%)
Query: 136 LEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASRE 195
L G VN T EG+ + AC + ++ L AN T LM A+
Sbjct: 254 LIEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANVEDRGIKGDITPLMAAANG 311
Query: 196 GVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPL 255
G V+IV+ +L +VNA + + A +A GG+ D++K+L + + NG+TPL
Sbjct: 312 GHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPL 371
Query: 256 HYAAMGGFADCCKYIAQRGCDLKWKNLDHK 285
A G + + + + G + + + K
Sbjct: 372 MEAGSAGHVEVARLLLENGAGINTHSNEFK 401
Score = 55.5 bits (132), Expect = 2e-07
Identities = 43/146 (29%), Positives = 70/146 (47%), Gaps = 5/146 (3%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFL---W 559
GD+ +++K G V+ ++ L AC++G ++ + LL ANV D +
Sbjct: 245 GDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE--DRGIKGDI 302
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQL 619
TPL A + G IV+LL+ A ++A S +T L A +D VK LL+ GA +
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 620 ENRKGHSAMDVAKAYADYRIIDLIKE 645
N GH+ + A + + L+ E
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLE 388
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/193 (24%), Positives = 89/193 (46%), Gaps = 7/193 (3%)
Query: 503 GDLASLKKAFESGIPVDMK-DNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
G A++K + G ++ + + T L AC G +VV LL++ ANV TP
Sbjct: 978 GHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTP 1037
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNS--TPLNRAIESCRLDTVKYLLDIGAKFQL 619
L A G ++ +L++ GA ++A + +S T L A + + L+ GA +
Sbjct: 1038 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDV 1097
Query: 620 ENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKTEGPEIKKEEE 679
N+KG++ + +A ++ L+ + ++ A+N+K+ TP + +K
Sbjct: 1098 RNKKGNTPLWLAANGGHLDVVQLLVQAGADV-DAADNRKI---TPLMAAFRKGHVKVVRY 1153
Query: 680 LLSSIYGVPTTSE 692
L+ + P+ SE
Sbjct: 1154 LVKEVNQFPSDSE 1166
Score = 52.4 bits (124), Expect = 2e-06
Identities = 35/131 (26%), Positives = 59/131 (45%), Gaps = 3/131 (2%)
Query: 526 KTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALID 585
+T L AC G ++V FL++ GA++ + TPL A G ++V+ L+ +GA +
Sbjct: 535 ETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVH 591
Query: 586 AASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKE 645
A + T L A E+ D LL GA + E+ G + + A + +
Sbjct: 592 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 646 KLDNLPKPAEN 656
K N+ + N
Sbjct: 652 KGANVNRTTAN 662
Score = 51.6 bits (122), Expect = 3e-06
Identities = 28/71 (39%), Positives = 36/71 (50%)
Query: 225 AAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDH 284
AA GG I+KLL A+ DV S GNT L YA GG+ D K + + G ++ N +
Sbjct: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367
Query: 285 KTPRAVAKEGG 295
TP A G
Sbjct: 368 HTPLMEAGSAG 378
Score = 47.4 bits (111), Expect = 5e-05
Identities = 43/164 (26%), Positives = 75/164 (45%), Gaps = 5/164 (3%)
Query: 529 LMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDAAS 588
L AC+ G+++ V+ LL +G +VN + L AC AG ++ ++L+ A ++
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 589 INNS-TPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKL 647
I TPL A + VK LL A ++ G++A+ A A +D++K L
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGG---YVDVVKVLL 354
Query: 648 DNLPKPAENQKLKGKTPPILKTEGPEIKKEEELLSSIYGVPTTS 691
++ E+ G TP + ++ LL + G+ T S
Sbjct: 355 ES-GASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397
Score = 47.0 bits (110), Expect = 7e-05
Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 1/114 (0%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
G L +K +G V T L AC +G+ DV LL+ GA++ TPL
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNS-TPLNRAIESCRLDTVKYLLDIGA 615
A AG V+ L+ GA ++ + NN T L+ A L V+ LL GA
Sbjct: 635 MKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Score = 46.6 bits (109), Expect = 9e-05
Identities = 39/138 (28%), Positives = 58/138 (42%), Gaps = 3/138 (2%)
Query: 160 AHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRH 219
A D LT + + NA S +L EA EG V VR +L G VN +
Sbjct: 211 ALDEAAAALTRMRAESTANAGQSDN--RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGE 268
Query: 220 HAAHFAAKGGFFDILKLLFAYNGDVGLISINGN-TPLHYAAMGGFADCCKYIAQRGCDLK 278
A G++++ ++L A + +V I G+ TPL AA GG K + D+
Sbjct: 269 SLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVN 328
Query: 279 WKNLDHKTPRAVAKEGGF 296
++ T A GG+
Sbjct: 329 AQSSTGNTALTYACAGGY 346
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 56/138 (40%), Gaps = 14/138 (10%)
Query: 35 GYPELINY---------TEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPT 85
G+ EL+ Y G +AL A + D+ LL GA + + G TP
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634
Query: 86 MRAAELGHELSMEILAK--AKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVN 143
M+AA GH +++ L A + T +N+ + C H + L HGAD
Sbjct: 635 MKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC---AGGHLAVVELLLAHGADPT 691
Query: 144 NSTYEGKPIFLRACEDAH 161
+ +G + + A + H
Sbjct: 692 HRLKDGSTMLIEAAKGGH 709
Score = 35.0 bits (79), Expect = 0.27
Identities = 50/217 (23%), Positives = 85/217 (39%), Gaps = 17/217 (7%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDN- 556
+ G L ++ ++G VD DN TPLM A G++ VV++L+ K N +D+
Sbjct: 1108 LAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV-KEVNQFPSDSE 1166
Query: 557 ---FLWT----PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKY 609
++ T + CH + IV+ A + N++ L ++ +L
Sbjct: 1167 CMRYIATITDKEMLKKCHLCMESIVQAKDRQA----AEANKNASILLEELDLEKLREESR 1222
Query: 610 LLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPILKT 669
L + AK E RK + I+ ++ L E +KLK + P + T
Sbjct: 1223 RLALAAK--REKRKEKRRKKKEEQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLT 1280
Query: 670 EGPEIKKEEELLSSIYGVPTTSEGKKVQKGNVVHLNS 706
E P + I TT G ++ N + S
Sbjct: 1281 EPPSATTTTTI--GISATWTTLAGSHGKRNNTITTTS 1315
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 79.0 bits (193), Expect = 2e-14
Identities = 67/246 (27%), Positives = 108/246 (43%), Gaps = 6/246 (2%)
Query: 47 NGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKAD 106
+G + L +A+ + ID V L+ GA ++Q G T AA+ GH + L A
Sbjct: 45 HGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGAS 104
Query: 107 MTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDV 166
+G L H + L+HGA++++ Y+G A + + DV
Sbjct: 105 TEFRTKDGGTALLAA--SQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGY--LDV 160
Query: 167 CLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAA 226
L GA N G L AS+ G E+VR +L RG + +A ND A AA
Sbjct: 161 IRLLLASGAKVNQPRQD-GTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAA 219
Query: 227 KGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKT 286
G+ D++K L ++ +G++ NG + LH A + G + + G D +N ++
Sbjct: 220 NKGYNDVIKELLKFSPTLGILK-NGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANEL 278
Query: 287 PRAVAK 292
P + K
Sbjct: 279 PAELTK 284
Score = 68.2 bits (165), Expect = 3e-11
Identities = 53/205 (25%), Positives = 87/205 (42%), Gaps = 5/205 (2%)
Query: 99 ILAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACE 158
+L + D+ D+ G +L + H C + GAD+N G A +
Sbjct: 31 LLNSGRVDVDCRDSHGTTLLM--VAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQ 88
Query: 159 DAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDR 218
H+ DV GA+ + G TAL+ AS+ G +++V +L+ G ++ D
Sbjct: 89 QGHN--DVVRFLFGFGASTE-FRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDG 145
Query: 219 HHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLK 278
A AA+GG+ D+++LL A V +G PL A+ G ++ + + RG D
Sbjct: 146 ATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRD 205
Query: 279 WKNLDHKTPRAVAKEGGFKAASKEI 303
D T A G+ KE+
Sbjct: 206 AARNDGTTALLKAANKGYNDVIKEL 230
Score = 61.2 bits (147), Expect = 3e-09
Identities = 52/167 (31%), Positives = 82/167 (49%), Gaps = 6/167 (3%)
Query: 501 KAGDLASLKKAFESG-IPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLW 559
+ G+LA LK SG + VD +D++ T LM A +G+ID V+ L+ +GA++N
Sbjct: 21 RRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGT 80
Query: 560 TPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQL 619
T L FA G D+V L GA + + + T L A + + V+ LL GA
Sbjct: 81 TALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHD 140
Query: 620 ENRKGHSAMDVAKAYADYRIIDLIKEKLDNLPKPAENQKLKGKTPPI 666
+ G +A+ +A A +D+I+ L + K NQ + T P+
Sbjct: 141 QLYDGATALFLA---AQGGYLDVIRLLLASGAK--VNQPRQDGTAPL 182
Score = 49.7 bits (117), Expect = 1e-05
Identities = 39/149 (26%), Positives = 71/149 (47%), Gaps = 4/149 (2%)
Query: 498 IITKAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNF 557
+ + G L ++ SG V+ PL A G+ +VV+ +L +GA+ +A N
Sbjct: 151 LAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARND 210
Query: 558 LWTPLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKF 617
T L A + G D+++ L++ + N ++ L+ A+ S + TV LL+ GA
Sbjct: 211 GTTALLKAANKGYNDVIKELLKFSPTLGILK-NGTSALHAAVLSGNIKTVALLLEAGADP 269
Query: 618 QLENRKGHSAMDVAKAYADYRIIDLIKEK 646
L N+ ++ K + RI+ L++ K
Sbjct: 270 SLRNKANELPAELTK---NERILRLLRSK 295
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/139 (25%), Positives = 61/139 (43%)
Query: 502 AGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTP 561
AG + +++ G ++++ T L A G+ DVV+FL GA+ T
Sbjct: 56 AGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTA 115
Query: 562 LHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLEN 621
L A G +VE L++ GA I + +T L A + LD ++ LL GAK
Sbjct: 116 LLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPR 175
Query: 622 RKGHSAMDVAKAYADYRII 640
+ G + + +A ++
Sbjct: 176 QDGTAPLWIASQMGHSEVV 194
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/119 (29%), Positives = 54/119 (45%), Gaps = 1/119 (0%)
Query: 527 TPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELLVESGALIDA 586
T L A G +DV++ LL GA VN PL A G ++V +++ GA DA
Sbjct: 147 TALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDA 206
Query: 587 ASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAKAYADYRIIDLIKE 645
A + +T L +A D +K LL + + G SA+ A + + + L+ E
Sbjct: 207 ARNDGTTALLKAANKGYNDVIKELLKFSPTLGI-LKNGTSALHAAVLSGNIKTVALLLE 264
Score = 33.1 bits (74), Expect = 1.0
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 220 HAAHFAAKGGFFDILKLLF-AYNGDVGLISINGNTPLHYAAMGGFADCCKYIAQRGCDLK 278
+AA +AA+ G +LKLL + DV +G T L AA G DC + + +G D+
Sbjct: 14 NAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADIN 73
Query: 279 WKNLDHKTPRAVAKEGG 295
+ T A + G
Sbjct: 74 LQRESGTTALFFAAQQG 90
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 78.6 bits (192), Expect = 2e-14
Identities = 42/115 (36%), Positives = 65/115 (56%)
Query: 518 VDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQDIVELL 577
V+ ++ +TPL A G++ VK L+ GANVN D WTPLH AC+ G D+ ++L
Sbjct: 155 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 214
Query: 578 VESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKGHSAMDVAK 632
+ +GA ++ +++ TPL+ + S D VK LL G N+ G +DVA+
Sbjct: 215 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE 269
Score = 56.2 bits (134), Expect = 1e-07
Identities = 35/96 (36%), Positives = 51/96 (53%)
Query: 503 GDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPL 562
GD+ +K+ G V++KD TPL AC G DV K L+ GA+VN TPL
Sbjct: 173 GDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTPL 232
Query: 563 HFACHAGQQDIVELLVESGALIDAASINNSTPLNRA 598
H + +G +DIV+LL+ G A+ + P++ A
Sbjct: 233 HDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/164 (25%), Positives = 73/164 (44%), Gaps = 1/164 (0%)
Query: 185 GRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDV 244
G T L A+ G V+ V+ ++ G VN D H A G++D+ K+L A DV
Sbjct: 162 GETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADV 221
Query: 245 GLISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASK-EI 303
++ +TPLH +A G D K + + G + N + P VA+ + K E+
Sbjct: 222 NTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREV 281
Query: 304 RRAERIANKLARPGAKNPNPLWALRLHDWSVEREAFLREAFAVL 347
++ + A++ NP D E+++ + E+ +L
Sbjct: 282 PLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQIL 325
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/60 (36%), Positives = 35/60 (58%)
Query: 48 GLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADM 107
G + LH+A++ D+ V L+ LGA+ +V+D G TP A +G+ +IL A AD+
Sbjct: 162 GETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADV 221
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/97 (30%), Positives = 45/97 (46%), Gaps = 2/97 (2%)
Query: 162 DVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERGGEVNAFDNDRHHA 221
DVK V + GAN N + G T L EA G ++ + ++ G +VN D
Sbjct: 174 DVKQV-KELISLGANVN-VKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQGLDDDTP 231
Query: 222 AHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYA 258
H +A G DI+KLL + G+ + +G P+ A
Sbjct: 232 LHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA 268
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,806,502
Number of Sequences: 37866
Number of extensions: 1411063
Number of successful extensions: 8733
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 336
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 3216
Number of HSP's gapped (non-prelim): 3255
length of query: 776
length of database: 18,247,518
effective HSP length: 110
effective length of query: 666
effective length of database: 14,082,258
effective search space: 9378783828
effective search space used: 9378783828
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.