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Search of human proteins with 38524622
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38524622 formin binding protein 1 [Homo sapiens]
(617 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38524622 formin binding protein 1 [Homo sapiens] 1254 0.0
gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens] 610 e-174
gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens] 609 e-174
gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens] 550 e-156
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 66 8e-11
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 66 8e-11
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 64 4e-10
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 63 7e-10
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 63 7e-10
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 63 7e-10
gi|20149528 proline-serine-threonine phosphatase interacting pro... 60 6e-09
gi|165905601 proline-serine-threonine phosphatase interacting pr... 58 2e-08
gi|195546919 growth arrest-specific 7 isoform d [Homo sapiens] 57 7e-08
gi|41406080 growth arrest-specific 7 isoform c [Homo sapiens] 57 7e-08
gi|41406078 growth arrest-specific 7 isoform b [Homo sapiens] 57 7e-08
gi|41406076 growth arrest-specific 7 isoform a [Homo sapiens] 57 7e-08
gi|24308229 protein kinase C and casein kinase substrate in neur... 55 2e-07
gi|28875786 FCH and double SH3 domains 1 [Homo sapiens] 55 2e-07
gi|226371723 FCH domain only 2 isoform a [Homo sapiens] 54 4e-07
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] 53 7e-07
gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sap... 51 3e-06
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 50 5e-06
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 50 5e-06
gi|194306660 coiled-coil domain containing 77 isoform b [Homo sa... 48 2e-05
gi|194306658 coiled-coil domain containing 77 isoform b [Homo sa... 48 2e-05
gi|14150165 coiled-coil domain containing 77 isoform a [Homo sap... 48 2e-05
gi|194306535 coiled-coil domain containing 77 isoform b [Homo sa... 48 2e-05
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 48 3e-05
gi|19224660 protein kinase C and casein kinase substrate in neur... 48 3e-05
gi|148747351 protein kinase C and casein kinase substrate in neu... 47 4e-05
>gi|38524622 formin binding protein 1 [Homo sapiens]
Length = 617
Score = 1254 bits (3245), Expect = 0.0
Identities = 617/617 (100%), Positives = 617/617 (100%)
Query: 1 MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSK 60
MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSK
Sbjct: 1 MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSK 60
Query: 61 EEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG 120
EEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG
Sbjct: 61 EEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG 120
Query: 121 RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRH 180
RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRH
Sbjct: 121 RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRH 180
Query: 181 QMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQ 240
QMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQ
Sbjct: 181 QMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQ 240
Query: 241 VIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL 300
VIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL
Sbjct: 241 VIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL 300
Query: 301 SNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSP 360
SNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSP
Sbjct: 301 SNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSP 360
Query: 361 KQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDE 420
KQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDE
Sbjct: 361 KQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDE 420
Query: 421 LNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLA 480
LNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLA
Sbjct: 421 LNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLA 480
Query: 481 EVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFD 540
EVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFD
Sbjct: 481 EVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFD 540
Query: 541 DEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGY 600
DEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGY
Sbjct: 541 DEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGY 600
Query: 601 VPTSYVEVCLDKNAKDS 617
VPTSYVEVCLDKNAKDS
Sbjct: 601 VPTSYVEVCLDKNAKDS 617
>gi|41581463 formin binding protein 1-like isoform 2 [Homo sapiens]
Length = 547
Score = 610 bits (1573), Expect = e-174
Identities = 310/624 (49%), Positives = 426/624 (68%), Gaps = 84/624 (13%)
Query: 1 MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSK 60
MSWGTELWDQFD+L+KHTQWGID LE+Y KFVKER EIE +YAKQLRNL KKY PK++SK
Sbjct: 1 MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60
Query: 61 EEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG 120
+EE ++TSC AF + LNE+NDYAGQ EV++E MA ++ +L RY +LK ERK + +G
Sbjct: 61 DEEP-RFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEG 119
Query: 121 RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRH 180
RKAQQ+++ CWKQ+++SK++FER+C+EA++AQQ +E++D D N TKADVEKA+QQ +R
Sbjct: 120 RKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRT 179
Query: 181 QMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQ 240
MA+++K +Y++ LQ FN EQH++++ IP I++++QEM+ERR +++ E + +A+ +R+
Sbjct: 180 HMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERK 239
Query: 241 VIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL 300
VIPII KCL+G++ AA+S+D++ DSQ+V++++KSGFEPPGD FEDY+Q + RT+SD ++
Sbjct: 240 VIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTI 299
Query: 301 SNSRGE-GKPDLKFG-GKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQ 358
S S+ E GK D K GK+KGKLW F KK K +L H P
Sbjct: 300 SASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLP------------------ 341
Query: 359 SPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKV 418
P+Q+++ L R +E
Sbjct: 342 -PEQRRKKLQQRIDE--------------------------------------------- 355
Query: 419 DELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAW 478
LN+E+QKE DQ+DA+ KMKDVY KNPQMGDP SL KLAE NI++LR+E K EAW
Sbjct: 356 --LNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAW 413
Query: 479 LAEVEGRLPARSEQARRQSGLYDSQNPPTVNN-CAQDRESPDGSYTEEQSQE----SEMK 533
L+EVEG+ R D ++ +N+ Q RESP+GSYT++ +QE +
Sbjct: 414 LSEVEGKTGGRG----------DRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQH 463
Query: 534 VLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRR 593
+FDDEF+D++PLPAIG CKA+Y F+G NEGT+++ EGE LY+IEEDKGDGWTR RR
Sbjct: 464 GHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARR 523
Query: 594 NEDEEGYVPTSYVEVCLDKNAKDS 617
EEGYVPTSY++V L+KN+K S
Sbjct: 524 QNGEEGYVPTSYIDVTLEKNSKGS 547
>gi|68348709 formin binding protein 1-like isoform 1 [Homo sapiens]
Length = 551
Score = 609 bits (1570), Expect = e-174
Identities = 309/622 (49%), Positives = 425/622 (68%), Gaps = 84/622 (13%)
Query: 1 MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSK 60
MSWGTELWDQFD+L+KHTQWGID LE+Y KFVKER EIE +YAKQLRNL KKY PK++SK
Sbjct: 1 MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK 60
Query: 61 EEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG 120
+EE ++TSC AF + LNE+NDYAGQ EV++E MA ++ +L RY +LK ERK + +G
Sbjct: 61 DEEP-RFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEG 119
Query: 121 RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRH 180
RKAQQ+++ CWKQ+++SK++FER+C+EA++AQQ +E++D D N TKADVEKA+QQ +R
Sbjct: 120 RKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRT 179
Query: 181 QMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQ 240
MA+++K +Y++ LQ FN EQH++++ IP I++++QEM+ERR +++ E + +A+ +R+
Sbjct: 180 HMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERK 239
Query: 241 VIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL 300
VIPII KCL+G++ AA+S+D++ DSQ+V++++KSGFEPPGD FEDY+Q + RT+SD ++
Sbjct: 240 VIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTI 299
Query: 301 SNSRGE-GKPDLKFG-GKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQ 358
S S+ E GK D K GK+KGKLW F KK K +L H P
Sbjct: 300 SASKQESGKMDAKTTVGKAKGKLWLFGKKPKGPALEDFSHLP------------------ 341
Query: 359 SPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKV 418
P+Q+++ L R +E
Sbjct: 342 -PEQRRKKLQQRIDE--------------------------------------------- 355
Query: 419 DELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAW 478
LN+E+QKE DQ+DA+ KMKDVY KNPQMGDP SL KLAE NI++LR+E K EAW
Sbjct: 356 --LNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAW 413
Query: 479 LAEVEGRLPARSEQARRQSGLYDSQNPPTVNN-CAQDRESPDGSYTEEQSQE----SEMK 533
L+EVEG+ R D ++ +N+ Q RESP+GSYT++ +QE +
Sbjct: 414 LSEVEGKTGGRG----------DRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQH 463
Query: 534 VLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRR 593
+FDDEF+D++PLPAIG CKA+Y F+G NEGT+++ EGE LY+IEEDKGDGWTR RR
Sbjct: 464 GHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARR 523
Query: 594 NEDEEGYVPTSYVEVCLDKNAK 615
EEGYVPTSY++V L+KN+K
Sbjct: 524 QNGEEGYVPTSYIDVTLEKNSK 545
>gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]
Length = 545
Score = 550 bits (1418), Expect = e-156
Identities = 287/616 (46%), Positives = 408/616 (66%), Gaps = 76/616 (12%)
Query: 1 MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSK 60
M WGTELWDQF+ LE+HTQWG+D+L++Y+KFVKERTE+E +YAKQLR+L KKY PK+ +K
Sbjct: 1 MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAK 60
Query: 61 EEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG 120
++ E K++ ++F+ L E+ND+AGQ E+++EN++ ++ ++L +Y QE+KQERK +F +G
Sbjct: 61 DDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEG 120
Query: 121 RKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRH 180
R+AQQ +E +KQLE+SKR+FERDC+EA++A Q E++D DIN TKADVEKA+QQA +R
Sbjct: 121 RRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRS 180
Query: 181 QMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQ 240
MAE+SK +Y++ LQ+FN +Q +Y + +P IF K+Q+M+ERR R+G +E + +
Sbjct: 181 HMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELE 240
Query: 241 VIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSL 300
V+PII KCL+G+ AA ++D KNDS ++IE +KSGF PGD+EFED++QPM R SD+SL
Sbjct: 241 VVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSL 300
Query: 301 SNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSP 360
+ +G+P+L+ G+S+ K WPF KKNK + H P P
Sbjct: 301 -GTPSDGRPELRGPGRSRTKRWPFGKKNKTVVTEDFSHLP-------------------P 340
Query: 361 KQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDE 420
+QQ++ L + E+R ++L
Sbjct: 341 EQQRKRLQQQL------------------------------------EERSREL------ 358
Query: 421 LNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLA 480
QKE+DQR+A+ KMKDVY K PQMGDPASL+ ++AE NIE+L++E QK+EAWLA
Sbjct: 359 -----QKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLA 413
Query: 481 EVEGR-LPARSEQARRQSGLYD--SQNPP--TVNNCAQDRESPDGSYTEEQSQESEMKVL 535
E E R L R + R + D + PP + N+ +QD + S E S+ES+ +
Sbjct: 414 EAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKE---SSEEPPSEESQDTPI 470
Query: 536 ATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNE 595
T+FD++F +EEP IG C A+Y FEG +EGTIS+ EGE L ++EEDKGDGWTR+RR E
Sbjct: 471 YTEFDEDF-EEEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKE 529
Query: 596 DEEGYVPTSYVEVCLD 611
EGYVPTSY+ V L+
Sbjct: 530 GGEGYVPTSYLRVTLN 545
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
[Homo sapiens]
Length = 1075
Score = 66.2 bits (160), Expect = 8e-11
Identities = 66/314 (21%), Positives = 133/314 (42%), Gaps = 33/314 (10%)
Query: 5 TELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEE 64
T+L +QF LE+ ++ + +L+ +F + + EIEL Y++ L L++++ K S E +
Sbjct: 26 TQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQ 85
Query: 65 YKY-------TSCKAFI--SNLNEMNDYAGQHEVISENM---ASQIIVDLARYVQELKQE 112
+K +C + E D+A +++ N+ SQI D+ R ++ K+
Sbjct: 86 FKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEI 145
Query: 113 RKSNFHDGRKAQQHIETCWK---QLESSKRRFERDCKEADRAQ--QYFEKMDADINVTK- 166
+ K + T K + E KEA++ + Q+ + D +N+ +
Sbjct: 146 GLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRH 205
Query: 167 ADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEY-------------YHTHIPNIF 213
D + R + +M E +A YS K +++Y Y+ H ++
Sbjct: 206 EDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIH--DVS 263
Query: 214 QKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYK 273
I + + + +TY + + + LD I A +++D ++D V++
Sbjct: 264 DLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCN 323
Query: 274 SGFEPPGDIEFEDY 287
F PP EF+ +
Sbjct: 324 QVFCPPLKFEFQPH 337
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
[Homo sapiens]
Length = 1099
Score = 66.2 bits (160), Expect = 8e-11
Identities = 66/314 (21%), Positives = 133/314 (42%), Gaps = 33/314 (10%)
Query: 5 TELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEE 64
T+L +QF LE+ ++ + +L+ +F + + EIEL Y++ L L++++ K S E +
Sbjct: 26 TQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQ 85
Query: 65 YKY-------TSCKAFI--SNLNEMNDYAGQHEVISENM---ASQIIVDLARYVQELKQE 112
+K +C + E D+A +++ N+ SQI D+ R ++ K+
Sbjct: 86 FKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEI 145
Query: 113 RKSNFHDGRKAQQHIETCWK---QLESSKRRFERDCKEADRAQ--QYFEKMDADINVTK- 166
+ K + T K + E KEA++ + Q+ + D +N+ +
Sbjct: 146 GLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRH 205
Query: 167 ADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEY-------------YHTHIPNIF 213
D + R + +M E +A YS K +++Y Y+ H ++
Sbjct: 206 EDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIH--DVS 263
Query: 214 QKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYK 273
I + + + +TY + + + LD I A +++D ++D V++
Sbjct: 264 DLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCN 323
Query: 274 SGFEPPGDIEFEDY 287
F PP EF+ +
Sbjct: 324 QVFCPPLKFEFQPH 337
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 63.9 bits (154), Expect = 4e-10
Identities = 60/287 (20%), Positives = 125/287 (43%), Gaps = 9/287 (3%)
Query: 1 MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSK 60
M +G++L + + + K W + +LE KF+ R + + YA L+NL Q K S
Sbjct: 1 MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCN--QVDKEST 58
Query: 61 EEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKS--NFH 118
+ Y K+++ + + + + +E++ S + L +++ +Q +KS H
Sbjct: 59 VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118
Query: 119 DGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQI 178
+A+ I+ +LE K + + KE + A++ +++ A T+ E+ +
Sbjct: 119 QQIEAEM-IKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMK 177
Query: 179 RHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVD 238
H + Y L+ Q++YY +P + +Q+M+E I + Y+++
Sbjct: 178 LHMLHNQ----YVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQIT 233
Query: 239 RQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFE 285
V I I + E ID + I+ +++ +IEF+
Sbjct: 234 SLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFD 280
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo
sapiens]
Length = 1085
Score = 63.2 bits (152), Expect = 7e-10
Identities = 63/314 (20%), Positives = 134/314 (42%), Gaps = 35/314 (11%)
Query: 6 ELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPK-KNSKEEEE 64
+L +Q LE+ T+ + +L+ F +++ EIE Y++ L L++++ K +++K+ ++
Sbjct: 27 QLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQ 86
Query: 65 YK-----YTSCKAFISNLNEMNDYAGQHEVISENMASQIIV-------DLARYVQELKQE 112
YK + + LN++ + H +S+ + +I+ D R ++ K+
Sbjct: 87 YKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEI 146
Query: 113 RKSNFHDGRKAQQHIETCWK---QLESSKRRFERDCKEADRAQQ--------------YF 155
D K + T K + E KEA++ ++
Sbjct: 147 AFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLE 206
Query: 156 EKMDADINVTKADVEKARQQAQIRHQMAEDSKA--DYSSILQKFNHEQHEYYHTHIPNIF 213
E+ +V K + K ++QA+ + KA +Y L+ N +YY I ++
Sbjct: 207 ERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYY---IHDLS 263
Query: 214 QKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYK 273
I + + +++TY + + + LD I A ++++ ++D Q +E Y
Sbjct: 264 DLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYP 323
Query: 274 SGFEPPGDIEFEDY 287
+ F PP EF+ +
Sbjct: 324 AAFCPPMKFEFQSH 337
Score = 33.1 bits (74), Expect = 0.78
Identities = 25/103 (24%), Positives = 43/103 (41%), Gaps = 6/103 (5%)
Query: 506 PTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQN 565
P C + D Y+E + E + T+ D+ EP+ AI A + + G++
Sbjct: 703 PVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAI----AKFDYVGRS 758
Query: 566 EGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVEV 608
+S +G +L + D W R+ +G VP Y+ V
Sbjct: 759 ARELSFKKGASLLLYHRASEDWWE--GRHNGIDGLVPHQYIVV 799
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 63.2 bits (152), Expect = 7e-10
Identities = 62/332 (18%), Positives = 144/332 (43%), Gaps = 52/332 (15%)
Query: 6 ELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEY 65
+L +Q L++ + + +L+ F +++ EIE+ Y++ L L++++ K S +++++
Sbjct: 27 QLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQF 86
Query: 66 KY--------------------------TSCKAFISNLN----EMNDYAGQHEVISENMA 95
K T +++N+ ++++ +G+ S+ +
Sbjct: 87 KKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVG 146
Query: 96 SQIIVDLARYVQELKQERKSNFH----DGRKAQQHIETCWKQLESSKRRFERDCKEADRA 151
Q+ DL + + EL K+ +H D AQ ++ KQ E ++ + K+ DR
Sbjct: 147 QQLQDDLMKVLNELYSVMKT-YHMYNADSISAQSKLKEAEKQEE---KQIGKSVKQEDRQ 202
Query: 152 QQYFEKMDADINVTKADV--------EKARQQAQIRHQ----MAEDSKADYSSILQKFNH 199
A++ + + V EK +++ Q ++ A ++ +Y L+ N
Sbjct: 203 TPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNA 262
Query: 200 EQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESI 259
+YY + ++ + ++ + +++T+ + + + LD I A E++
Sbjct: 263 SVFKYYIHDLSDLIDQCCDLGYH--ASLNRALRTFLSAELNLEQSKHEGLDAIENAVENL 320
Query: 260 DQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPM 291
D +D Q ++E Y + F PP EF+ + M
Sbjct: 321 DATSDKQRLMEMYNNVFCPPMKFEFQPHMGDM 352
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 63.2 bits (152), Expect = 7e-10
Identities = 62/332 (18%), Positives = 144/332 (43%), Gaps = 52/332 (15%)
Query: 6 ELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEY 65
+L +Q L++ + + +L+ F +++ EIE+ Y++ L L++++ K S +++++
Sbjct: 27 QLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQF 86
Query: 66 KY--------------------------TSCKAFISNLN----EMNDYAGQHEVISENMA 95
K T +++N+ ++++ +G+ S+ +
Sbjct: 87 KKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVG 146
Query: 96 SQIIVDLARYVQELKQERKSNFH----DGRKAQQHIETCWKQLESSKRRFERDCKEADRA 151
Q+ DL + + EL K+ +H D AQ ++ KQ E ++ + K+ DR
Sbjct: 147 QQLQDDLMKVLNELYSVMKT-YHMYNADSISAQSKLKEAEKQEE---KQIGKSVKQEDRQ 202
Query: 152 QQYFEKMDADINVTKADV--------EKARQQAQIRHQ----MAEDSKADYSSILQKFNH 199
A++ + + V EK +++ Q ++ A ++ +Y L+ N
Sbjct: 203 TPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNA 262
Query: 200 EQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESI 259
+YY + ++ + ++ + +++T+ + + + LD I A E++
Sbjct: 263 SVFKYYIHDLSDLIDQCCDLGYH--ASLNRALRTFLSAELNLEQSKHEGLDAIENAVENL 320
Query: 260 DQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPM 291
D +D Q ++E Y + F PP EF+ + M
Sbjct: 321 DATSDKQRLMEMYNNVFCPPMKFEFQPHMGDM 352
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 60.1 bits (144), Expect = 6e-09
Identities = 57/265 (21%), Positives = 118/265 (44%), Gaps = 25/265 (9%)
Query: 30 KFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEV 89
+ +++R + E Y K+L +++K + + S +A +L + + G +
Sbjct: 41 ELLRQRAQAEERYGKELVQIARK--------AGGQTEINSLRASFDSLKQQMENVGSSHI 92
Query: 90 ISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEAD 149
+ + L + + K++RK + Q+ + +K+ SK+ +E+ C++AD
Sbjct: 93 QLALTLREELRSLEEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDAD 152
Query: 150 RAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTH- 208
A+Q FE++ A N + VEK++ +A+ A +++ Y + + + E+ H
Sbjct: 153 DAEQAFERISA--NGHQKQVEKSQNKARQCKDSATEAERVYRQSIAQLEKVRAEWEQEHR 210
Query: 209 -IPNIFQKIQEMEERRIVR-----MGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQK 262
FQ +QE + I+R + D ++ + L+G SID
Sbjct: 211 TTCEAFQ-LQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGC-----SIDAD 264
Query: 263 NDSQLVIEAYKSGFEPPGDIEFEDY 287
DS I+A +G EPP + +++Y
Sbjct: 265 IDS--FIQAKSTGTEPPAPVPYQNY 287
Score = 39.7 bits (91), Expect = 0.008
Identities = 21/52 (40%), Positives = 31/52 (59%), Gaps = 2/52 (3%)
Query: 556 KALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVE 607
+ALY + QN + + G+ L VI E + DGW + RN + G+VP SY+E
Sbjct: 365 RALYDYTAQNPDELDLSAGDILEVILEGE-DGWWTVERN-GQRGFVPGSYLE 414
>gi|165905601 proline-serine-threonine phosphatase interacting
protein 2 [Homo sapiens]
Length = 334
Score = 58.2 bits (139), Expect = 2e-08
Identities = 59/286 (20%), Positives = 123/286 (43%), Gaps = 12/286 (4%)
Query: 11 FDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSC 70
+DN+ +H G +++ F+KER IE Y K L NLS+K K + E +
Sbjct: 21 YDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRK---KPCGQSEINTLKRAL 77
Query: 71 KAFISNLNEMNDYAGQHEVISENMASQI-IVDLARYVQELKQERKSNFHDGRKAQQHIET 129
+ F ++++ A H +++++ + ++ R Q+L++++ D Q+ ++
Sbjct: 78 EVF---KQQVDNVAQCHIQLAQSLREEARKMEEFREKQKLQRKKTELIMDAIHKQKSLQ- 133
Query: 130 CWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKAD 189
+K+ +K+ +E+ C++ D A+Q + +N + EK + EDS
Sbjct: 134 -FKKTMDAKKNYEQKCRDKDEAEQAVSRSANLVNPKQQ--EKLFVKLATSKTAVEDSDKA 190
Query: 190 YSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCL 249
Y + + + E+ HI + + E RI ++ + Q +
Sbjct: 191 YMLHIGTLDKVREEWQSEHI-KACEAFEAQECERINFFRNALWLHVNQLSQQCVTSDEMY 249
Query: 250 DGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTV 295
+ + K+ E + D + + K+G PP I +E++ K V
Sbjct: 250 EQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQKNAV 295
>gi|195546919 growth arrest-specific 7 isoform d [Homo sapiens]
Length = 412
Score = 56.6 bits (135), Expect = 7e-08
Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 27/268 (10%)
Query: 21 GIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEM 80
G + ++ +F++ER +IE YAK NL+K Q S+EE +A+ +
Sbjct: 166 GKQMQKEMSEFIRERIKIEEDYAK---NLAKLSQNSLASQEEGSLG----EAWAQVKKSL 218
Query: 81 NDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRR 140
D A H S + S++ L + + K++ K K HI KQL S
Sbjct: 219 ADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMK-------KCDHHIADLRKQLASRYAS 271
Query: 141 FERDCKEADRAQQYFEKMDADI-----NVTKADVEKARQQAQIRHQMAEDSKADYSSILQ 195
E+ K Q+ E + N T+ D++KAR++ + + D +
Sbjct: 272 VEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRK-------STQAGDDLMRCVD 324
Query: 196 KFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKA 255
+N Q +++ + + ++ +E R+ + + + Y ++ + ++ + +
Sbjct: 325 LYNQAQSKWFEEMVTTTLE-LERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQL 383
Query: 256 AESIDQKNDSQLVIEAYKSGFEPPGDIE 283
+D D +L + +K+G P D+E
Sbjct: 384 LRKVDPAKDRELWVREHKTGNIRPVDME 411
>gi|41406080 growth arrest-specific 7 isoform c [Homo sapiens]
Length = 476
Score = 56.6 bits (135), Expect = 7e-08
Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 27/268 (10%)
Query: 21 GIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEM 80
G + ++ +F++ER +IE YAK NL+K Q S+EE +A+ +
Sbjct: 230 GKQMQKEMSEFIRERIKIEEDYAK---NLAKLSQNSLASQEEGSLG----EAWAQVKKSL 282
Query: 81 NDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRR 140
D A H S + S++ L + + K++ K K HI KQL S
Sbjct: 283 ADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMK-------KCDHHIADLRKQLASRYAS 335
Query: 141 FERDCKEADRAQQYFEKMDADI-----NVTKADVEKARQQAQIRHQMAEDSKADYSSILQ 195
E+ K Q+ E + N T+ D++KAR++ + + D +
Sbjct: 336 VEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRK-------STQAGDDLMRCVD 388
Query: 196 KFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKA 255
+N Q +++ + + ++ +E R+ + + + Y ++ + ++ + +
Sbjct: 389 LYNQAQSKWFEEMVTTTLE-LERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQL 447
Query: 256 AESIDQKNDSQLVIEAYKSGFEPPGDIE 283
+D D +L + +K+G P D+E
Sbjct: 448 LRKVDPAKDRELWVREHKTGNIRPVDME 475
Score = 33.5 bits (75), Expect = 0.59
Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 2/55 (3%)
Query: 555 CKALYTFEGQNEGT-ISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVEV 608
C+ LY F G+ G + GE + +++ G GW + + G+ P SYV++
Sbjct: 6 CRTLYPFSGERHGQGLRFAAGELITLLQVPDG-GWWEGEKEDGLRGWFPASYVQL 59
>gi|41406078 growth arrest-specific 7 isoform b [Homo sapiens]
Length = 416
Score = 56.6 bits (135), Expect = 7e-08
Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 27/268 (10%)
Query: 21 GIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEM 80
G + ++ +F++ER +IE YAK NL+K Q S+EE +A+ +
Sbjct: 170 GKQMQKEMSEFIRERIKIEEDYAK---NLAKLSQNSLASQEEGSLG----EAWAQVKKSL 222
Query: 81 NDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRR 140
D A H S + S++ L + + K++ K K HI KQL S
Sbjct: 223 ADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMK-------KCDHHIADLRKQLASRYAS 275
Query: 141 FERDCKEADRAQQYFEKMDADI-----NVTKADVEKARQQAQIRHQMAEDSKADYSSILQ 195
E+ K Q+ E + N T+ D++KAR++ + + D +
Sbjct: 276 VEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRK-------STQAGDDLMRCVD 328
Query: 196 KFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKA 255
+N Q +++ + + ++ +E R+ + + + Y ++ + ++ + +
Sbjct: 329 LYNQAQSKWFEEMVTTTLE-LERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQL 387
Query: 256 AESIDQKNDSQLVIEAYKSGFEPPGDIE 283
+D D +L + +K+G P D+E
Sbjct: 388 LRKVDPAKDRELWVREHKTGNIRPVDME 415
>gi|41406076 growth arrest-specific 7 isoform a [Homo sapiens]
Length = 336
Score = 56.6 bits (135), Expect = 7e-08
Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 27/268 (10%)
Query: 21 GIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEM 80
G + ++ +F++ER +IE YAK NL+K Q S+EE +A+ +
Sbjct: 90 GKQMQKEMSEFIRERIKIEEDYAK---NLAKLSQNSLASQEEGSLG----EAWAQVKKSL 142
Query: 81 NDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRR 140
D A H S + S++ L + + K++ K K HI KQL S
Sbjct: 143 ADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMK-------KCDHHIADLRKQLASRYAS 195
Query: 141 FERDCKEADRAQQYFEKMDADI-----NVTKADVEKARQQAQIRHQMAEDSKADYSSILQ 195
E+ K Q+ E + N T+ D++KAR++ + + D +
Sbjct: 196 VEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRK-------STQAGDDLMRCVD 248
Query: 196 KFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKA 255
+N Q +++ + + ++ +E R+ + + + Y ++ + ++ + +
Sbjct: 249 LYNQAQSKWFEEMVTTTLE-LERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQL 307
Query: 256 AESIDQKNDSQLVIEAYKSGFEPPGDIE 283
+D D +L + +K+G P D+E
Sbjct: 308 LRKVDPAKDRELWVREHKTGNIRPVDME 335
>gi|24308229 protein kinase C and casein kinase substrate in neurons
1 [Homo sapiens]
Length = 444
Score = 55.1 bits (131), Expect = 2e-07
Identities = 55/288 (19%), Positives = 128/288 (44%), Gaps = 20/288 (6%)
Query: 32 VKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSC-KAFISNLNEMNDYAGQHEVI 90
V+ER +IE +Y +QL + +K+++ E+ +Y S +A+ + + E + + H+ +
Sbjct: 46 VQERAKIEKAYGQQLTDWAKRWR----QLIEKGPQYGSLERAWGAIMTEADKVSELHQEV 101
Query: 91 SENMASQIIVDLARYVQELKQER-------KSNFHDG-RKAQQHIETCWKQLESSKRRFE 142
N+ ++ + + + ++ ++ DG RKAQ+ K+LE++K+ +
Sbjct: 102 KNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYH 161
Query: 143 RDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQH 202
CKE A + +VT +K + + Q + ++ Y +L+
Sbjct: 162 LACKEEKLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTP 221
Query: 203 EYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQK 262
+Y ++ +F++ Q+ EE+R+V + E + ++ R + + + E +
Sbjct: 222 QYME-NMEQVFEQCQQFEEKRLVFLKEVL---LDIKRHLNLAENSSYIHVYRELEQAIRG 277
Query: 263 NDSQLVIEAYKSGFEPPGDI---EFEDYTQPMKRTVSDNSLSNSRGEG 307
D+Q + ++S P + +FE++ + T + + EG
Sbjct: 278 ADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKKEKQPKKAEG 325
Score = 49.7 bits (117), Expect = 8e-06
Identities = 63/313 (20%), Positives = 127/313 (40%), Gaps = 76/313 (24%)
Query: 361 KQQKEPLSHRFNEFMTSKPKIH-CFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVD 419
++ ++P + + E +K H + K ++ ++ + E ++ PEQ+ KKLQ KVD
Sbjct: 140 RKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQ--SVTPEQQ-KKLQDKVD 196
Query: 420 ELNKEIQKEMDQRDAITK------------------------------MKDVYL---KNP 446
+ +++QK ++ + + + +K+V L ++
Sbjct: 197 KCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHL 256
Query: 447 QMGDPASLDHKLAEVSQNI------EKLR-----------VETQKFEAWLAEVEGRLPAR 489
+ + +S H E+ Q I E LR + +FE W ++ +
Sbjct: 257 NLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKK 316
Query: 490 SEQARRQSGLYDSQNPPTVNNCAQ----------DRESPDGS-YTEEQSQE----SEMKV 534
+Q ++ G+ + V + +Q DR P + +++++S SE
Sbjct: 317 EKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDDESGNPFGGSETNG 376
Query: 535 LATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRN 594
A F+D+ +ALY ++GQ + +S G+ L + E+ GW R R +
Sbjct: 377 GANPFEDDSKGVR-------VRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLD 429
Query: 595 EDEEGYVPTSYVE 607
+ G P +YVE
Sbjct: 430 SGQLGLYPANYVE 442
>gi|28875786 FCH and double SH3 domains 1 [Homo sapiens]
Length = 690
Score = 54.7 bits (130), Expect = 2e-07
Identities = 46/184 (25%), Positives = 83/184 (45%), Gaps = 31/184 (16%)
Query: 453 SLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCA 512
S++ +L EV ++I + +V K A LA ++G +GL + A
Sbjct: 367 SIEQRLQEVRESIRRAQVSQVKGAARLALLQG------------AGLDVERWLKPAMTQA 414
Query: 513 QDRESPDGSYTEEQSQESEMKVLATDFD-DEFDD--------EEPLPAIGTCKAL----- 558
QD + +E + + ++ A D + +F++ EEP P +AL
Sbjct: 415 QDEVEQERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALATRALPCPAH 474
Query: 559 --YTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYV---EVCLDKN 613
+ ++ E +++ EGE L VIEE D W + R E G+VP Y+ ++ L ++
Sbjct: 475 VVFRYQAGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPES 534
Query: 614 AKDS 617
++DS
Sbjct: 535 SQDS 538
>gi|226371723 FCH domain only 2 isoform a [Homo sapiens]
Length = 810
Score = 53.9 bits (128), Expect = 4e-07
Identities = 64/300 (21%), Positives = 126/300 (42%), Gaps = 54/300 (18%)
Query: 3 WGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEE 62
WG E FD L + + G ++ FV+ER IE +Y++ + L+K
Sbjct: 11 WG-EKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKS---------- 59
Query: 63 EEYKYTSCKAFISNLNEMNDYAGQHEVI--SENMASQIIVDLARYVQELKQE-------- 112
SN +++ +A +V S + +DL R +QEL +E
Sbjct: 60 -----------ASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQ 108
Query: 113 ------RKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTK 166
K +A Q I++ + L+ SK + C E +R ++ T+
Sbjct: 109 VKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKE--------GATQ 160
Query: 167 ADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVR 226
++EKA ++ + A D+ Y ++K+ + ++ + QK Q++EE ++
Sbjct: 161 REIEKAA----VKSKKATDT---YKLYVEKYALAKADF-EQKMTETAQKFQDIEETHLIH 212
Query: 227 MGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFED 286
+ E + + + +++ IG+ + + + ++ Q E+ +G E PG IEFE+
Sbjct: 213 IKEIIGSLSNAIKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEE 272
>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
Length = 740
Score = 53.1 bits (126), Expect = 7e-07
Identities = 44/169 (26%), Positives = 69/169 (40%), Gaps = 20/169 (11%)
Query: 452 ASLDHKLAEVSQNIEKLRVETQKFEAWL-------AEVEGRLPARSEQARRQSGLYDSQN 504
A L+ K+ E +NI K + K EA L V+ L + Q +
Sbjct: 365 AELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWAR 424
Query: 505 PPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIG------TCKAL 558
PP V + S + E+ +E E D D FDD P+ TCK +
Sbjct: 425 PPAVTSNGT-LHSLNADTEREEGEEFE------DNMDVFDDSSSSPSGTLRNYPLTCKVV 477
Query: 559 YTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVE 607
Y+++ +++ E E L VIE+ + W + R + GYVP Y++
Sbjct: 478 YSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQ 526
Score = 48.9 bits (115), Expect = 1e-05
Identities = 54/223 (24%), Positives = 100/223 (44%), Gaps = 20/223 (8%)
Query: 9 DQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKY----QPKKNSKEEEE 64
+Q L+ Q D+LE F +++ IE YA+ ++ L+ +Y P + + +
Sbjct: 20 EQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRND 79
Query: 65 YK--YTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDG-R 121
Y+ Y K+F+ ++ A I EN I + AR V+ LK+++ D
Sbjct: 80 YRSMYPVWKSFLEGTMQV---AQSRMNICENY-KNFISEPARTVRSLKEQQLKRCVDQLT 135
Query: 122 KAQQHIETCWKQLESSKRR-FERD------CKEAD-RAQQYFEKMDADINVTKADVEKAR 173
K Q ++ K L K++ FE + ++AD A+ + I++ KA V+
Sbjct: 136 KIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKA 195
Query: 174 QQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKI 216
++++ + A ++ DY L N Q YY T + NI + +
Sbjct: 196 RRSEC-NSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKAL 237
>gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo
sapiens]
Length = 506
Score = 51.2 bits (121), Expect = 3e-06
Identities = 49/220 (22%), Positives = 90/220 (40%), Gaps = 32/220 (14%)
Query: 403 SNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVS 462
S + E+R+ L+ K+ L ++I+K ++ + +M Y D S A +
Sbjct: 291 SAMDKERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMD 350
Query: 463 QN---IEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTVNNCAQDRESPD 519
+N ++ L + K + LAE+E R + P N+ + RE
Sbjct: 351 ENNLKLDLLEANSYKLSSMLAELEQR---------------PQPSHPCSNSIFRWREKEH 395
Query: 520 GSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGT------------CKALYTFEGQNEG 567
+ S+ MK L + P T CKALY+F+ + +
Sbjct: 396 THSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDD 455
Query: 568 TISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVE 607
+++ +G+ + +I E K +GW N ++G+ P +YVE
Sbjct: 456 ELNLEKGD-IVIIHEKKEEGWWFGSLN-GKKGHFPAAYVE 493
Score = 50.8 bits (120), Expect = 4e-06
Identities = 56/269 (20%), Positives = 114/269 (42%), Gaps = 25/269 (9%)
Query: 11 FDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSC 70
+ NL++ +Q G + ++ +++R +E+SYAK L+ L+ K K + + +S
Sbjct: 14 YKNLKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKL--SKALQNTRKSCVSSA 71
Query: 71 KAFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETC 130
A+ S M A H+ + + + + I + + +++RKS ++ K + +
Sbjct: 72 WAWAS--EGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISN 129
Query: 131 WKQLESSKRRFERDCKEADRAQQYFEKMDAD---------INVTKADVEKARQQAQIRHQ 181
W Q +K++ K+ + Q E +N EK ++ + +Q
Sbjct: 130 WNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQ 189
Query: 182 MAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQV 241
+ A YS+ L+ + + N +Q I E+E+ RI + ++ Y++
Sbjct: 190 ---KNMAGYSTRLK---------WENTLENCYQSILELEKERIQLLCNNLNQYSQHISLF 237
Query: 242 IPIIGKCLDGIVKAAESIDQKNDSQLVIE 270
+ C I A ID + D Q V+E
Sbjct: 238 GQTLTTCHTQIHCAISKIDIEKDIQAVME 266
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 50.4 bits (119), Expect = 5e-06
Identities = 92/483 (19%), Positives = 187/483 (38%), Gaps = 66/483 (13%)
Query: 12 DNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCK 71
D + T G+ +E+ I EI++ ++ SK+ K++ +E++ + K
Sbjct: 757 DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERK 816
Query: 72 AFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCW 131
F + ++ E+ + + +DL+ V ++K++ K H H E C
Sbjct: 817 TFEK----------EKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSH-------HTEKCH 859
Query: 132 KQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYS 191
K+ E SK K+ D ++ EKMD + K + E+ +++ +H M + +K +
Sbjct: 860 KEGEKSKNTAA--IKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN 917
Query: 192 SILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDG 251
S EY + +K +E++++ R ES+
Sbjct: 918 S----------EYSKSEKGKNKEKDRELDKKEKSRDKESI-------------------N 948
Query: 252 IVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDL 311
I + ++K S +++ K+ E P ++ + +P+K D + + +
Sbjct: 949 ITNSKHIQEEKKSS--IVDGNKAQHEKPLSLKEKTKDEPLK--TPDGKEKDKKDKDIDRY 1004
Query: 312 KFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRF 371
K K K K I+ N L+ L + +P P +SP++ P+ + + L
Sbjct: 1005 KERDKHKDK----IQINSLLKLKSEADKPKP----KSSPASKDTRPKEKRLVNDDLMQTS 1056
Query: 372 NEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQ 431
E M S + + K+ E N + + K ++K E + +
Sbjct: 1057 FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELT 1116
Query: 432 RDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSE 491
R +++ D Y K Q D S SQ+++ V T +++++ RSE
Sbjct: 1117 RSKSSEVTDAYTKEKQPKDAVS------NRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSE 1170
Query: 492 QAR 494
+
Sbjct: 1171 NEK 1173
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 50.4 bits (119), Expect = 5e-06
Identities = 92/483 (19%), Positives = 187/483 (38%), Gaps = 66/483 (13%)
Query: 12 DNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCK 71
D + T G+ +E+ I EI++ ++ SK+ K++ +E++ + K
Sbjct: 780 DKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERK 839
Query: 72 AFISNLNEMNDYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCW 131
F + ++ E+ + + +DL+ V ++K++ K H H E C
Sbjct: 840 TFEK----------EKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSH-------HTEKCH 882
Query: 132 KQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYS 191
K+ E SK K+ D ++ EKMD + K + E+ +++ +H M + +K +
Sbjct: 883 KEGEKSKNTAA--IKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN 940
Query: 192 SILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDG 251
S EY + +K +E++++ R ES+
Sbjct: 941 S----------EYSKSEKGKNKEKDRELDKKEKSRDKESI-------------------N 971
Query: 252 IVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDL 311
I + ++K S +++ K+ E P ++ + +P+K D + + +
Sbjct: 972 ITNSKHIQEEKKSS--IVDGNKAQHEKPLSLKEKTKDEPLK--TPDGKEKDKKDKDIDRY 1027
Query: 312 KFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRF 371
K K K K I+ N L+ L + +P P +SP++ P+ + + L
Sbjct: 1028 KERDKHKDK----IQINSLLKLKSEADKPKP----KSSPASKDTRPKEKRLVNDDLMQTS 1079
Query: 372 NEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQ 431
E M S + + K+ E N + + K ++K E + +
Sbjct: 1080 FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELT 1139
Query: 432 RDAITKMKDVYLKNPQMGDPASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSE 491
R +++ D Y K Q D S SQ+++ V T +++++ RSE
Sbjct: 1140 RSKSSEVTDAYTKEKQPKDAVS------NRSQSVDTKNVMTLGKSSFVSDNSLNRSPRSE 1193
Query: 492 QAR 494
+
Sbjct: 1194 NEK 1196
>gi|194306660 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/262 (18%), Positives = 110/262 (41%), Gaps = 19/262 (7%)
Query: 22 IDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMN 81
+ IL+K I+ V E + E S K +SK+ +P + KE E+ + I + +
Sbjct: 139 VTILQKTIQAVGECEQSESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQ 197
Query: 82 DYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRF 141
G+ +S +I D +++E++ + + N Q I+ K L ++
Sbjct: 198 AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRN-------QNKIKELTKNLHHTQELL 250
Query: 142 ERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQ 201
K+ + + + + + K ++ +Q +++ + ED ++ + +H Q
Sbjct: 251 YESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQ 310
Query: 202 HEYYHT---------HIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGI 252
EY + + N++Q+ E + R+ E E+ + +GK L +
Sbjct: 311 SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIM 370
Query: 253 VKAAESIDQKNDSQLVIEAYKS 274
K E+++++ L +E +K+
Sbjct: 371 TKRYEALERRR--ILEVEGFKT 390
>gi|194306658 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/262 (18%), Positives = 110/262 (41%), Gaps = 19/262 (7%)
Query: 22 IDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMN 81
+ IL+K I+ V E + E S K +SK+ +P + KE E+ + I + +
Sbjct: 139 VTILQKTIQAVGECEQSESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQ 197
Query: 82 DYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRF 141
G+ +S +I D +++E++ + + N Q I+ K L ++
Sbjct: 198 AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRN-------QNKIKELTKNLHHTQELL 250
Query: 142 ERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQ 201
K+ + + + + + K ++ +Q +++ + ED ++ + +H Q
Sbjct: 251 YESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQ 310
Query: 202 HEYYHT---------HIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGI 252
EY + + N++Q+ E + R+ E E+ + +GK L +
Sbjct: 311 SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIM 370
Query: 253 VKAAESIDQKNDSQLVIEAYKS 274
K E+++++ L +E +K+
Sbjct: 371 TKRYEALERRR--ILEVEGFKT 390
>gi|14150165 coiled-coil domain containing 77 isoform a [Homo
sapiens]
Length = 488
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/262 (18%), Positives = 110/262 (41%), Gaps = 19/262 (7%)
Query: 22 IDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMN 81
+ IL+K I+ V E + E S K +SK+ +P + KE E+ + I + +
Sbjct: 171 VTILQKTIQAVGECEQSESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQ 229
Query: 82 DYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRF 141
G+ +S +I D +++E++ + + N Q I+ K L ++
Sbjct: 230 AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRN-------QNKIKELTKNLHHTQELL 282
Query: 142 ERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQ 201
K+ + + + + + K ++ +Q +++ + ED ++ + +H Q
Sbjct: 283 YESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQ 342
Query: 202 HEYYHT---------HIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGI 252
EY + + N++Q+ E + R+ E E+ + +GK L +
Sbjct: 343 SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIM 402
Query: 253 VKAAESIDQKNDSQLVIEAYKS 274
K E+++++ L +E +K+
Sbjct: 403 TKRYEALERRR--ILEVEGFKT 422
>gi|194306535 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/262 (18%), Positives = 110/262 (41%), Gaps = 19/262 (7%)
Query: 22 IDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMN 81
+ IL+K I+ V E + E S K +SK+ +P + KE E+ + I + +
Sbjct: 139 VTILQKTIQAVGECEQSESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQ 197
Query: 82 DYAGQHEVISENMASQIIVDLARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRF 141
G+ +S +I D +++E++ + + N Q I+ K L ++
Sbjct: 198 AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRN-------QNKIKELTKNLHHTQELL 250
Query: 142 ERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQ 201
K+ + + + + + K ++ +Q +++ + ED ++ + +H Q
Sbjct: 251 YESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQ 310
Query: 202 HEYYHT---------HIPNIFQKIQEMEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGI 252
EY + + N++Q+ E + R+ E E+ + +GK L +
Sbjct: 311 SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIM 370
Query: 253 VKAAESIDQKNDSQLVIEAYKS 274
K E+++++ L +E +K+
Sbjct: 371 TKRYEALERRR--ILEVEGFKT 390
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 47.8 bits (112), Expect = 3e-05
Identities = 46/160 (28%), Positives = 79/160 (49%), Gaps = 14/160 (8%)
Query: 332 SLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKR-G 390
S +SP PP PP +S S P +P ++ ++ +F + T K K+ R +R G
Sbjct: 291 SSTSSPEGPPAPPKQHSSTSPFPT--STPLRR---ITKKFVKGSTEKNKLRLQRDQERLG 345
Query: 391 LSLKLGATPEDFSNLPPEQRR-----KKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKN 445
LKL A E+ L E +R KK +++ EL ++ ++E ++D K + LK
Sbjct: 346 KQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKE 405
Query: 446 PQMGD-PASLDHKLAEVSQNIE--KLRVETQKFEAWLAEV 482
+ + +L+ KL E + E +LR E ++ +A AE+
Sbjct: 406 ERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEI 445
>gi|19224660 protein kinase C and casein kinase substrate in neurons
3 [Homo sapiens]
Length = 424
Score = 47.8 bits (112), Expect = 3e-05
Identities = 66/300 (22%), Positives = 109/300 (36%), Gaps = 69/300 (23%)
Query: 361 KQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDE 420
++ ++P R E SK H R ++ + D S + EQ RK LQ++V+
Sbjct: 137 RKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKAD-SAVSQEQLRK-LQERVER 194
Query: 421 LNKEIQK---------------------EMDQ---------RDAITKMKDVYLKNPQMGD 450
KE +K +M+Q R + KD+ L Q D
Sbjct: 195 CAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLD 254
Query: 451 PASLD---------HKLAEVSQNIEKLR-----------VETQKFEAWLAEVEGRLPARS 490
+S + H+ E + + E LR + +FE W + + + +
Sbjct: 255 LSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRTISRKE 314
Query: 491 EQARRQSGLYDSQNPPTVNNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLP 550
+ R + + PT + A +SP T + D+E+ DEE
Sbjct: 315 KGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQ--------------DEEWSDEESPR 360
Query: 551 AIGT---CKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVE 607
T +ALY + GQ +S GE L + E+ GW + + G P +YVE
Sbjct: 361 KAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE 420
Score = 44.7 bits (104), Expect = 3e-04
Identities = 67/334 (20%), Positives = 132/334 (39%), Gaps = 48/334 (14%)
Query: 33 KERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISE 92
+ER IE +YA+QL + ++K+ + + E+ T KA+ + + H + E
Sbjct: 44 QERARIEKAYAQQLADWARKW---RGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVRE 100
Query: 93 NMASQIIVDLARYVQELKQERKSNFH--------------DG-RKAQQHIETCWKQLESS 137
+ Q + ++ ++ FH DG RKAQ+ K++E+S
Sbjct: 101 KLQGQDS-------ERVRAWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEAS 153
Query: 138 KRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKF 197
K+ + K+ AQ AD V++ + K +++ + + AE +KA Y L +
Sbjct: 154 KKSYHAARKDEKTAQTRESHAKADSAVSQEQLRKLQERVERCAKEAEKTKAQYEQTLAEL 213
Query: 198 NHEQHEYYHTHIPNIFQKIQEMEERRIVRMGESMKT-YAEVDRQVIPIIGKCLDGIVKAA 256
H Y + F+ Q E +R++ + + T + +D + + +
Sbjct: 214 -HRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTLHQHLDLSSSEKFHELHRDLHQGI 272
Query: 257 ESIDQKNDSQLVIEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGK 316
E+ + D + + G +FE+++ +RT+S +G PD
Sbjct: 273 EAASDEEDLRWWRSTHGPGMAMNWP-QFEEWSLDTQRTIS----RKEKGGRSPD------ 321
Query: 317 SKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASP 350
+ L S++ + PPP + SP
Sbjct: 322 ----------EVTLTSIVPTRDGTAPPPQSPGSP 345
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/133 (26%), Positives = 60/133 (45%), Gaps = 12/133 (9%)
Query: 487 PARSEQARRQSGLYDSQNPP--TVNNCAQDRESPDGSYTEEQS-------QESEMKVLAT 537
PA+S Q++ ++ ++ TV+ + SY + QS ES +T
Sbjct: 351 PAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSST 410
Query: 538 DFDDE---FDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRN 594
D + + FDD+ +ALY +EGQ +S G+ L +E++ GW + R +
Sbjct: 411 DANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLD 470
Query: 595 EDEEGYVPTSYVE 607
+ G P +YVE
Sbjct: 471 NGQVGLYPANYVE 483
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/199 (21%), Positives = 90/199 (45%), Gaps = 12/199 (6%)
Query: 34 ERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISEN 93
ER IE +YA+QL ++++ + E+ T KA+++ ++E + H + +
Sbjct: 47 ERARIEKAYAQQLTEWARRW---RQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKAS 103
Query: 94 MASQIIVDLARYVQEL--KQ------ERKSNFHDGRKAQQHIETCWKQLESSKRRFERDC 145
+ + + + +E KQ E K RKAQ+ K++E++K+ C
Sbjct: 104 LMNDDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAAC 163
Query: 146 KEADRAQQYFEKMDADINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYY 205
KE A AD ++ ++K + + + Q +K Y L++ + +Y
Sbjct: 164 KEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYM 223
Query: 206 HTHIPNIFQKIQEMEERRI 224
++ +F++ Q+ EE+R+
Sbjct: 224 E-NMEQVFEQCQQFEEKRL 241
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,552,171
Number of Sequences: 37866
Number of extensions: 1300312
Number of successful extensions: 15476
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 570
Number of HSP's that attempted gapping in prelim test: 12310
Number of HSP's gapped (non-prelim): 3241
length of query: 617
length of database: 18,247,518
effective HSP length: 108
effective length of query: 509
effective length of database: 14,157,990
effective search space: 7206416910
effective search space used: 7206416910
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.