Search of human proteins with 12548788

Search of human proteins with 12548788

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
         (473 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is...   963   0.0  
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso...   909   0.0  
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...   752   0.0  
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...   734   0.0  
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...   721   0.0  
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...   368   e-102
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre...   343   3e-94
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom...   330   1e-90
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec...   324   9e-89
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom...   314   1e-85
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...   314   1e-85
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]       293   2e-79
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]       292   4e-79
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]         292   4e-79
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]       292   5e-79
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo...   288   7e-78
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   286   2e-77
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]       286   2e-77
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo...   286   4e-77
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   285   5e-77
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]       282   5e-76
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr...   280   2e-75
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso...   279   5e-75
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...   276   2e-74
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...   276   2e-74
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor...   276   2e-74
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ...   271   1e-72
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso...   268   1e-71
gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform...   265   7e-71
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ...   265   7e-71

>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 2 precursor [Homo sapiens]
          Length = 473

 Score =  963 bits (2489), Expect = 0.0
 Identities = 473/473 (100%), Positives = 473/473 (100%)

Query: 1   MCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60
           MCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP
Sbjct: 1   MCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60

Query: 61  VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120
           VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD
Sbjct: 61  VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120

Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180
           TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
Sbjct: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180

Query: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240
           SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK
Sbjct: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240

Query: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300
           RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
Sbjct: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300

Query: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360
           PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR
Sbjct: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360

Query: 361 VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS 420
           VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS
Sbjct: 361 VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS 420

Query: 421 LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473
           LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
Sbjct: 421 LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473


>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 1 precursor [Homo sapiens]
          Length = 473

 Score =  909 bits (2348), Expect = 0.0
 Identities = 447/448 (99%), Positives = 448/448 (100%)

Query: 26  RSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT 85
           +SVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT
Sbjct: 26  QSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT 85

Query: 86  MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 145
           MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP
Sbjct: 86  MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 145

Query: 146 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER 205
           DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER
Sbjct: 146 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER 205

Query: 206 IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF 265
           IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF
Sbjct: 206 IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF 265

Query: 266 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA 325
           WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA
Sbjct: 266 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA 325

Query: 326 FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI 385
           FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI
Sbjct: 326 FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI 385

Query: 386 GDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDV 445
           GDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDV
Sbjct: 386 GDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDV 445

Query: 446 NAIDRWSRIVFPFTFSLFNLVYWLYYVN 473
           NAIDRWSRIVFPFTFSLFNLVYWLYYVN
Sbjct: 446 NAIDRWSRIVFPFTFSLFNLVYWLYYVN 473


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score =  752 bits (1942), Expect = 0.0
 Identities = 367/450 (81%), Positives = 404/450 (89%), Gaps = 2/450 (0%)

Query: 26  RSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT 85
           +SVNDP NMS VKETVD+LLKGYDIRLRPDFGGPPV VGMNIDIASIDMVSEVNMDYTLT
Sbjct: 25  QSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLT 84

Query: 86  MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 145
           MYFQQ WRDKRL+Y+ IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP
Sbjct: 85  MYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 144

Query: 146 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER 205
           DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRG D AVTGV +
Sbjct: 145 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTK 204

Query: 206 IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF 265
           IELPQFSIV+++L+++ VVF+TG+YPRLSLSF+LKRNIGYFILQTYMPSILITILSWVSF
Sbjct: 205 IELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSF 264

Query: 266 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA 325
           WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVF+ALLEYA
Sbjct: 265 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYA 324

Query: 326 FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEM--NEVSG 383
            VNYIFFGRGPQRQKK AEK A A N++ + + N++D H NILL++LE+ NEM  +E   
Sbjct: 325 LVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVM 384

Query: 384 GIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLT 443
           G+GD R++ +++D S IQYRK  +PR   GR   +R +  KK+ LRRR+SQLKI IPDLT
Sbjct: 385 GLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLT 444

Query: 444 DVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473
           DVNAIDRWSRI FP  FS FN+VYWLYYVN
Sbjct: 445 DVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score =  734 bits (1895), Expect = 0.0
 Identities = 367/488 (75%), Positives = 404/488 (82%), Gaps = 40/488 (8%)

Query: 26  RSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT 85
           +SVNDP NMS VKETVD+LLKGYDIRLRPDFGGPPV VGMNIDIASIDMVSEVNMDYTLT
Sbjct: 25  QSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLT 84

Query: 86  MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 145
           MYFQQ WRDKRL+Y+ IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP
Sbjct: 85  MYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 144

Query: 146 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER 205
           DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRG D AVTGV +
Sbjct: 145 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTK 204

Query: 206 IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF 265
           IELPQFSIV+++L+++ VVF+TG+YPRLSLSF+LKRNIGYFILQTYMPSILITILSWVSF
Sbjct: 205 IELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSF 264

Query: 266 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA 325
           WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVF+ALLEYA
Sbjct: 265 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYA 324

Query: 326 FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRV------------------------ 361
            VNYIFFGRGPQRQKK AEK A A N++ + + N++                        
Sbjct: 325 LVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSP 384

Query: 362 --------------DAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQ 405
                         D H NILL++LE+ NEM  +E   G+GD R++ +++D S IQYRK 
Sbjct: 385 TRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKA 444

Query: 406 SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNL 465
            +PR   GR   +R +  KK+ LRRR+SQLKI IPDLTDVNAIDRWSRI FP  FS FN+
Sbjct: 445 GLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNI 504

Query: 466 VYWLYYVN 473
           VYWLYYVN
Sbjct: 505 VYWLYYVN 512


>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score =  721 bits (1860), Expect = 0.0
 Identities = 357/451 (79%), Positives = 399/451 (88%), Gaps = 7/451 (1%)

Query: 27  SVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTM 86
           S N+P NMS+VKETVD+LLKGYDIRLRPDFGGPPV VGM ID+ASIDMVSEVNMDYTLTM
Sbjct: 27  STNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTM 86

Query: 87  YFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPD 146
           YFQQ W+DKRL+YSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPD
Sbjct: 87  YFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPD 146

Query: 147 GTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERI 206
           GTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW GG+ AVTGV +I
Sbjct: 147 GTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKI 206

Query: 207 ELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFW 266
           ELPQFSIV++++VS+ V F TGAYPRLSLSFRLKRNIGYFILQTYMPS LITILSWVSFW
Sbjct: 207 ELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFW 266

Query: 267 INYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAF 326
           INYDASAARVALGITTVLTMTTI+THLRETLPKIPYVKAID+YLMGCFVFVFLALLEYAF
Sbjct: 267 INYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAF 326

Query: 327 VNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR--VDAHGNILLTSLEVHNEM--NEVS 382
           VNYIFFG+GP  QKK A K  ++ N+++K E N+  VDAHGNILL++LE+ NE   +EV 
Sbjct: 327 VNYIFFGKGP--QKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVL 384

Query: 383 GGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDL 442
             + D + +  S+D++ IQYRK    RE +GR L    +P  K  +RRR+SQLK+KIPDL
Sbjct: 385 TSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVP-SKGRIRRRASQLKVKIPDL 443

Query: 443 TDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473
           TDVN+ID+WSR+ FP TFSLFN+VYWLYYV+
Sbjct: 444 TDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score =  368 bits (945), Expect = e-102
 Identities = 162/309 (52%), Positives = 235/309 (76%)

Query: 33  NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92
           N + V++ +D++L  YD+RLRP+FGG PV V ++I + SI+ +SE+NMDYT+TM+F Q W
Sbjct: 55  NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114

Query: 93  RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152
           +D RLAY    LNLTLD R+ ++LWVPD YFLN K +FVH VTV+NR+ +LHPDGTV YG
Sbjct: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174

Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFS 212
           +R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI  +W     A+   E + +PQF+
Sbjct: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFT 234

Query: 213 IVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDAS 272
            +   + S+ V F TG+Y RL L F+++R +  +++Q Y P++L TI SW+SFW+NYD+S
Sbjct: 235 FLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSS 294

Query: 273 AARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFF 332
           AARV +G+T++L +TTI++HLR+ LP I  +KAID+Y++ C  FVFL+LLEY ++NY+F+
Sbjct: 295 AARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFY 354

Query: 333 GRGPQRQKK 341
            RGP+RQ +
Sbjct: 355 SRGPRRQPR 363



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 15/28 (53%), Positives = 22/28 (78%)

Query: 445 VNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
           V  +D+WSR +FP  F LFN+VYW+Y++
Sbjct: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHM 631


>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
           precursor [Homo sapiens]
          Length = 452

 Score =  343 bits (879), Expect = 3e-94
 Identities = 194/476 (40%), Positives = 291/476 (61%), Gaps = 44/476 (9%)

Query: 8   LLLPIWLSWTLGTRGSEPRSVNDPGN-------MSFVKETVDKLLKGYDIRLRPDFGGPP 60
           LL P+ L      RG+  R++ND G+       +S++   +D L+ GY    RP  GGPP
Sbjct: 7   LLAPLLLLCAQQLRGT--RAMNDIGDYVGSNLEISWLPN-LDGLIAGYARNFRPGIGGPP 63

Query: 61  VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120
           V V + +++ASID +SE NM+YT+T++  Q WRD RL+Y+     L LD+R  D+LW+PD
Sbjct: 64  VNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPD 123

Query: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180
           T+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T AC MDL +YP+DEQ C L++E
Sbjct: 124 TFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLE 183

Query: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF-ATGAYPRLSLSFRL 239
           SYGY+++DI +YW    + + G+++++L QF+I  +R  +  + F + G +PRLSL F L
Sbjct: 184 SYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHL 243

Query: 240 KRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPK 299
           +RN G +I+Q+YMPS+L+  +SWVSFWI+  A  ARV+LGITTVLTMTT+    R +LP+
Sbjct: 244 RRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPR 303

Query: 300 IPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESN 359
              +KA+D+Y   C+VFVF AL+EYAF ++        R+K    + AK K  R ++E  
Sbjct: 304 ASAIKALDVYFWICYVFVFAALVEYAFAHF----NADYRKK----QKAKVKVSRPRAE-- 353

Query: 360 RVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPRE--GHGRFLG 417
            +D    I+L SL             G T+  AIS        R++ +P    G  R +G
Sbjct: 354 -MDVRNAIVLFSL----------SAAGVTQELAIS-------RRQRRVPGNLMGSYRSVG 395

Query: 418 DRSLPHKKTHLRRRSSQ--LKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471
             +   KK    R   Q  ++ ++  + D + ID ++R VFP  F+  N++YW  Y
Sbjct: 396 VETGETKKEGAARSGGQGGIRARLRPI-DADTIDIYARAVFPAAFAAVNVIYWAAY 450


>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
           sapiens]
          Length = 479

 Score =  330 bits (847), Expect = 1e-90
 Identities = 176/423 (41%), Positives = 268/423 (63%), Gaps = 33/423 (7%)

Query: 48  YDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY-SGIPLNL 106
           +D  +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y + YW+D+RL++ S   L++
Sbjct: 84  HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143

Query: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166
           T D R+  ++WVPD +F++ K+SF+H  T  N M+R+ PDG VLY LR+T TA C MD  
Sbjct: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203

Query: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF- 225
           R+PLD Q C+LEIESY YT DD+  YW+ G+ ++   ERI L QF I E    ++   + 
Sbjct: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263

Query: 226 ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285
           +TG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+  A  ARV LGITTVLT
Sbjct: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323

Query: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345
           M+TI T +  ++P++ Y+KA+D+YL   FVFVFL++LEYA VNY+   +  ++++KL EK
Sbjct: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ-ERKEQKLREK 382

Query: 346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ 405
                       ++ +      +L       E+N++   + +        D   +Q    
Sbjct: 383 LPC---------TSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP---DRMMVQLTLA 430

Query: 406 SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNL 465
           S           +RS P +K+   +RSS + ++I    D +AID++SRI+FP  + LFNL
Sbjct: 431 S-----------ERSSPQRKS---QRSSYVSMRI----DTHAIDKYSRIIFPAAYILFNL 472

Query: 466 VYW 468
           +YW
Sbjct: 473 IYW 475


>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
           precursor [Homo sapiens]
          Length = 490

 Score =  324 bits (831), Expect = 9e-89
 Identities = 172/434 (39%), Positives = 262/434 (60%), Gaps = 49/434 (11%)

Query: 48  YDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIP-LNL 106
           +D  +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y + YW+D+RLA+S     ++
Sbjct: 89  HDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSM 148

Query: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166
           T D R+  ++WVPD +F++ K+SF H  T  N M+R+ PDG VLY +RIT TA C MD  
Sbjct: 149 TFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFS 208

Query: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFA 226
            +PLD Q C+LE+ESY YT +D+  YW+ GD+++   E+I L QF I +    SR   ++
Sbjct: 209 HFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYS 268

Query: 227 -TGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285
            TG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+  A  ARV+LGITTVLT
Sbjct: 269 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLT 328

Query: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAE- 344
           MTTI T +  ++P++ YVKA+D+YL   FVFVFL++LEYA VNY+   +  ++++KL E 
Sbjct: 329 MTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ-ERKERKLREK 387

Query: 345 ----------KTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAIS 394
                     KT       S+SE+N +  +    + + E   +   V  G+    N+A  
Sbjct: 388 FPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAA-- 445

Query: 395 FDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRI 454
                                        +K  L +  +  +I      + +AID++SR+
Sbjct: 446 -----------------------------RKKGLLKGQTGFRI----FQNTHAIDKYSRL 472

Query: 455 VFPFTFSLFNLVYW 468
           +FP ++  FNL+YW
Sbjct: 473 IFPASYIFFNLIYW 486


>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
           sapiens]
          Length = 467

 Score =  314 bits (804), Expect = 1e-85
 Identities = 173/428 (40%), Positives = 259/428 (60%), Gaps = 35/428 (8%)

Query: 49  DIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY-SGIPLNLT 107
           D  +RP FGG PV VG+++ + SID +SE NMD+T+T Y + YW+D+RL++ S    ++T
Sbjct: 71  DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130

Query: 108 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 167
            D+R+  ++WVPD +F++ K+SF+H  T++N M+R+HPDG VL  LRIT +A C MD  R
Sbjct: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190

Query: 168 YPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF-- 225
           +PLD QNC+LE+ESY Y  DD+  YW+ G+K++   E + L QF  +E    S  + F  
Sbjct: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQF-FIEDFSASSGLAFYS 249

Query: 226 ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285
           +TG Y RL ++F L+R++ +F+LQTY P+IL+ +LSWVSFWI+  A  ARV+LGITTVLT
Sbjct: 250 STGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLT 309

Query: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345
           M+TI T +  ++P++ Y+KA+D+YL    +FVFL+++EYA VNY+        ++K  +K
Sbjct: 310 MSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL----TTVEERKQFKK 365

Query: 346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ 405
           T K       S    +DA   +        +E+        D   +++S ++     RK 
Sbjct: 366 TGKI------SRMYNIDAVQAMAFDGCYHDSEI--------DMDQTSLSLNSEDFMRRKS 411

Query: 406 -SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFN 464
              P     R              RR+S    +    L + + ID +SRI+FP  + LFN
Sbjct: 412 ICSPSTDSSRI------------KRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFN 459

Query: 465 LVYWLYYV 472
           L YW  YV
Sbjct: 460 LFYWGVYV 467


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score =  314 bits (804), Expect = 1e-85
 Identities = 174/432 (40%), Positives = 252/432 (58%), Gaps = 36/432 (8%)

Query: 42  DKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSG 101
           + L  GY+  LRP+FGG PV + + +DIASI  +SE NMDYT T+Y +Q W D+RL + G
Sbjct: 42  ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101

Query: 102 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 161
              + TLD R+ + LWVPDTY +  KKSF+H VTV NR+IRL  +GTVLY LRITTT AC
Sbjct: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160

Query: 162 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSR 221
            MDL +YP+D Q C L++ES+GY  +D+EF W  G+ +V G+E + L Q++I  +  +  
Sbjct: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220

Query: 222 NVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT 281
                TG Y RL L F L+RN+ YFIL+TY+PS  + +LSWVSFWI+ D+  AR  +G+T
Sbjct: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280

Query: 282 TVLTMTTINTHLRETLPKIP-YVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340
           TVL+MTT+    R +LP    ++KAID+YL  CF FVF ALLEYA  +Y           
Sbjct: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY----------S 330

Query: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGI 400
            L +  AK   DR  ++     +  NI+ +S+                  ++I   +  +
Sbjct: 331 SLQQMAAK---DRGTTKEVEEVSITNIINSSISSFKRKISF---------ASIEISSDNV 378

Query: 401 QYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTF 460
            Y   +M      +F+            R +  ++ +    + + + +D +S+++FP  F
Sbjct: 379 DYSDLTMKTSDKFKFV-----------FREKMGRI-VDYFTIQNPSNVDHYSKLLFPLIF 426

Query: 461 SLFNLVYWLYYV 472
            L N+ YW YY+
Sbjct: 427 MLANVFYWAYYM 438


>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
          Length = 464

 Score =  293 bits (750), Expect = 2e-79
 Identities = 169/436 (38%), Positives = 252/436 (57%), Gaps = 36/436 (8%)

Query: 41  VDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL 97
           +DKL+    GYD R+RP+F GPPV V  NI I S   ++E  MDY + ++ +Q W D RL
Sbjct: 47  LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRL 106

Query: 98  AYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156
           AYS  P + L LD  + D +W PD +F N+K +  H VT  N+++R+  +G VLY +R+T
Sbjct: 107 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 166

Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216
            T +C MDL+ +P+D Q C +++ES+GYT +D+ F W+  +  V   E + LPQF + E 
Sbjct: 167 LTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQD-EAPVQVAEGLTLPQFLLKEE 225

Query: 217 R-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAAR 275
           + L      + TG +  + + F L+R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ AR
Sbjct: 226 KDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 285

Query: 276 VALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRG 335
           VALGITTVLTMTT ++  R +LPK+ YVKAID+++  C +FVF ALLEYA VN++     
Sbjct: 286 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFV----- 340

Query: 336 PQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISF 395
            ++ K+L     K KN   K+E+            +LE     +++   + ++R S  ++
Sbjct: 341 SRQHKELLRFRRKRKN---KTEA-----------FALEKFYRFSDMDDEVRESRFSFTAY 386

Query: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455
                   K  M  +G          P+    +  +S     K+  +     ID  SR  
Sbjct: 387 GMGPCLQAKDGMTPKG----------PNHPVQVMPKSPDEMRKV-FIDRAKKIDTISRAC 435

Query: 456 FPFTFSLFNLVYWLYY 471
           FP  F +FN+ YW+ Y
Sbjct: 436 FPLAFLIFNIFYWVIY 451


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  292 bits (748), Expect = 4e-79
 Identities = 174/454 (38%), Positives = 250/454 (55%), Gaps = 49/454 (10%)

Query: 24  EPRSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNM 80
           + RS   P       + +DKL+    GYD R+RP+F GPPV V  NI I S   V+E  M
Sbjct: 31  DSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTM 90

Query: 81  DYTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNR 139
           DY + ++ +Q W D RLAYS  P + L LD  + D +W PD +F N+K +  H VT  N+
Sbjct: 91  DYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNK 150

Query: 140 MIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKA 199
           ++R+  +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W   D  
Sbjct: 151 LLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGP 209

Query: 200 VTGVERIELPQFSIVEHRLVSRNVV-FATGAYPRLSLSFRLKRNIGYFILQTYMPSILIT 258
           V   E + LPQF + E + +      + TG +  + + F L+R +GY+++Q Y+PS+LI 
Sbjct: 210 VQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIV 269

Query: 259 ILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVF 318
           ILSWVSFWIN DA+ ARVALGITTVLTMTT ++  R +LPK+ YVKAID+++  C +FVF
Sbjct: 270 ILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVF 329

Query: 319 LALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEM 378
            ALLEYA VN++       RQ K   +  + +  ++K E                     
Sbjct: 330 AALLEYAAVNFV------SRQHKEFLRLRRRQKRQNKEED-------------------- 363

Query: 379 NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHG-RFLGDRSLPHKKTHLRRRSSQLKI 437
                    TR S  +F   G+ +  Q   ++G   +      LP       +    +K 
Sbjct: 364 --------VTRESRFNFSGYGMGHCLQ--VKDGTAVKATPANPLPQPP----KDGDAIKK 409

Query: 438 KIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471
           K  D      ID  SR  FP  F +FN+ YW+ Y
Sbjct: 410 KFVD--RAKRIDTISRAAFPLAFLIFNIFYWITY 441


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  292 bits (748), Expect = 4e-79
 Identities = 174/454 (38%), Positives = 250/454 (55%), Gaps = 49/454 (10%)

Query: 24  EPRSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNM 80
           + RS   P       + +DKL+    GYD R+RP+F GPPV V  NI I S   V+E  M
Sbjct: 31  DSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTM 90

Query: 81  DYTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNR 139
           DY + ++ +Q W D RLAYS  P + L LD  + D +W PD +F N+K +  H VT  N+
Sbjct: 91  DYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNK 150

Query: 140 MIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKA 199
           ++R+  +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W   D  
Sbjct: 151 LLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGP 209

Query: 200 VTGVERIELPQFSIVEHRLVSRNVV-FATGAYPRLSLSFRLKRNIGYFILQTYMPSILIT 258
           V   E + LPQF + E + +      + TG +  + + F L+R +GY+++Q Y+PS+LI 
Sbjct: 210 VQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIV 269

Query: 259 ILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVF 318
           ILSWVSFWIN DA+ ARVALGITTVLTMTT ++  R +LPK+ YVKAID+++  C +FVF
Sbjct: 270 ILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVF 329

Query: 319 LALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEM 378
            ALLEYA VN++       RQ K   +  + +  ++K E                     
Sbjct: 330 AALLEYAAVNFV------SRQHKEFLRLRRRQKRQNKEED-------------------- 363

Query: 379 NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHG-RFLGDRSLPHKKTHLRRRSSQLKI 437
                    TR S  +F   G+ +  Q   ++G   +      LP       +    +K 
Sbjct: 364 --------VTRESRFNFSGYGMGHCLQ--VKDGTAVKATPANPLPQPP----KDGDAIKK 409

Query: 438 KIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471
           K  D      ID  SR  FP  F +FN+ YW+ Y
Sbjct: 410 KFVD--RAKRIDTISRAAFPLAFLIFNIFYWITY 441


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score =  292 bits (747), Expect = 5e-79
 Identities = 173/454 (38%), Positives = 250/454 (55%), Gaps = 49/454 (10%)

Query: 24  EPRSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNM 80
           + RS   P       + +DKL+    GYD R+RP+F GPPV V  NI I S   ++E  M
Sbjct: 31  DSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTM 90

Query: 81  DYTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNR 139
           DY + ++ +Q W D RLAYS  P + L LD  + D +W PD +F N+K +  H VT  N+
Sbjct: 91  DYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNK 150

Query: 140 MIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKA 199
           ++R+  +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W   D  
Sbjct: 151 LLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLS-DGP 209

Query: 200 VTGVERIELPQFSIVEHRLVSRNVV-FATGAYPRLSLSFRLKRNIGYFILQTYMPSILIT 258
           V   E + LPQF + E + +      + TG +  + + F L+R +GY+++Q Y+PS+LI 
Sbjct: 210 VQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIV 269

Query: 259 ILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVF 318
           ILSWVSFWIN DA+ ARVALGITTVLTMTT ++  R +LPK+ YVKAID+++  C +FVF
Sbjct: 270 ILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVF 329

Query: 319 LALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEM 378
            ALLEYA VN++       RQ K   +  + +  ++K E                     
Sbjct: 330 AALLEYAAVNFV------SRQHKEFLRLRRRQKRQNKEED-------------------- 363

Query: 379 NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHG-RFLGDRSLPHKKTHLRRRSSQLKI 437
                    TR S  +F   G+ +  Q   ++G   +      LP       +    +K 
Sbjct: 364 --------VTRESRFNFSGYGMGHCLQ--VKDGTAVKATPANPLPQPP----KDGDAIKK 409

Query: 438 KIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471
           K  D      ID  SR  FP  F +FN+ YW+ Y
Sbjct: 410 KFVD--RAKRIDTISRAAFPLAFLIFNIFYWITY 441


>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 457

 Score =  288 bits (737), Expect = 7e-78
 Identities = 172/466 (36%), Positives = 254/466 (54%), Gaps = 41/466 (8%)

Query: 12  IWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNID 68
           ++ S          RS   P + S   + +DKL+    GYD R+RP+F GPPV V  NI 
Sbjct: 16  VFFSLAASKEAEAARSAPKPMSPS---DFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIF 72

Query: 69  IASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDK 127
           I S   ++E  MDY + ++ +Q W D RLAY+  P + L LD  + D +W PD +F N+K
Sbjct: 73  INSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEK 132

Query: 128 KSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTD 187
            +  H +T  N+++R+  +G VLY +RIT T AC MDL+ +P+D Q C +++ES+GYT +
Sbjct: 133 GAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMN 192

Query: 188 DIEFYWRGGDKAVTGVERIELPQFSIVEHR-LVSRNVVFATGAYPRLSLSFRLKRNIGYF 246
           D+ F W+    AV   + + LPQF + E + L      + TG +  +   F L+R +GY+
Sbjct: 193 DLIFEWQE-QGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYY 251

Query: 247 ILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAI 306
           ++Q Y+PS+LI ILSW+SFWIN DA+ ARV LGITTVLTMTT ++  R +LPK+ YVKAI
Sbjct: 252 LIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAI 311

Query: 307 DMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGN 366
           D+++  C +FVF ALLEYA VN++      ++ K+L     K ++ +S            
Sbjct: 312 DIWMAVCLLFVFSALLEYAAVNFV-----SRQHKELLRFRRKRRHHKS------------ 354

Query: 367 ILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ-SMPREGHGRFLGDRSLPHKK 425
                  + N   E   G G    SA     + +Q +   S+    +         P K 
Sbjct: 355 ------PMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKS 408

Query: 426 THLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471
               R+    + K         ID+ SRI FP  F +FN+ YW+ Y
Sbjct: 409 PEEMRKLFIQRAK--------KIDKISRIGFPMAFLIFNMFYWIIY 446


>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
           precursor [Homo sapiens]
          Length = 475

 Score =  286 bits (733), Expect = 2e-77
 Identities = 158/437 (36%), Positives = 238/437 (54%), Gaps = 38/437 (8%)

Query: 41  VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
           ++ LL+GYD +LRPD G  P  +  ++ + SI  V+ +NM+YT+ ++F Q W D+RL ++
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                L L++ +  ++W+PDT+F N KK+  H +T  NRM+R+  DG VLY LR+T  A 
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220
           C + L  +P+DE +C LE  SYGY  ++I + W+     V       L QFS V  R  +
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249

Query: 221 RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280
             V   +G Y  +S+ F L R +GYF +QTY+P  LI +LSWVSFWIN DA  AR +LGI
Sbjct: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309

Query: 281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340
           TTVLTMTT++T  R++LPK+ YV A+D+++  CF+FVF AL+EY  ++Y    R P + K
Sbjct: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369

Query: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGI-----GDTRNSAISF 395
              +K    +    K+ +  +      +  +   H +  +   G       D  +    F
Sbjct: 370 DKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCF 429

Query: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455
           ++           R G  R        H + H+R               +  +D ++RI 
Sbjct: 430 EDC----------RTGAWR--------HGRIHIR---------------IAKMDSYARIF 456

Query: 456 FPFTFSLFNLVYWLYYV 472
           FP  F LFNLVYW+ Y+
Sbjct: 457 FPTAFCLFNLVYWVSYL 473


>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
          Length = 449

 Score =  286 bits (733), Expect = 2e-77
 Identities = 165/436 (37%), Positives = 243/436 (55%), Gaps = 51/436 (11%)

Query: 41  VDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL 97
           +DKL+    GYD R+RP+F GPPV V  NI I S   ++E  MDY + ++ +Q W D RL
Sbjct: 47  LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRL 106

Query: 98  AYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156
           AYS  P + L LD  + D +W PD +F N+K +  H VT  N+++R+  +G VLY +R+T
Sbjct: 107 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 166

Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216
            T +C MDL+ +P+D Q C +++ES+GYT +D+ F W+  +  V   E + LPQF + E 
Sbjct: 167 LTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQD-EAPVQVAEGLTLPQFLLKEE 225

Query: 217 R-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAAR 275
           + L      + TG +  + + F L+R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ AR
Sbjct: 226 KDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 285

Query: 276 VALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRG 335
           VALGITTVLTMTT ++  R +LPK+ YVKAID+++  C +FVF ALLEYA VN++     
Sbjct: 286 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFV----- 340

Query: 336 PQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISF 395
            ++ K+L     K KN   +   +R                  +  + G+G    +    
Sbjct: 341 SRQHKELLRFRRKRKNKDDEVRESR-----------------FSFTAYGMGPCLQAKDGM 383

Query: 396 DNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIV 455
              G  +  Q MP+                       S  +++   +     ID  SR  
Sbjct: 384 TPKGPNHPVQVMPK-----------------------SPDEMRKVFIDRAKKIDTISRAC 420

Query: 456 FPFTFSLFNLVYWLYY 471
           FP  F +FN+ YW+ Y
Sbjct: 421 FPLAFLIFNIFYWVIY 436


>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 449

 Score =  286 bits (731), Expect = 4e-77
 Identities = 169/465 (36%), Positives = 250/465 (53%), Gaps = 47/465 (10%)

Query: 12  IWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNID 68
           ++ S          RS   P + S   + +DKL+    GYD R+RP+F GPPV V  NI 
Sbjct: 16  VFFSLAASKEAEAARSAPKPMSPS---DFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIF 72

Query: 69  IASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDK 127
           I S   ++E  MDY + ++ +Q W D RLAY+  P + L LD  + D +W PD +F N+K
Sbjct: 73  INSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEK 132

Query: 128 KSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTD 187
            +  H +T  N+++R+  +G VLY +RIT T AC MDL+ +P+D Q C +++ES+GYT +
Sbjct: 133 GAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMN 192

Query: 188 DIEFYWRGGDKAVTGVERIELPQFSIVEHR-LVSRNVVFATGAYPRLSLSFRLKRNIGYF 246
           D+ F W+    AV   + + LPQF + E + L      + TG +  +   F L+R +GY+
Sbjct: 193 DLIFEWQE-QGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYY 251

Query: 247 ILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAI 306
           ++Q Y+PS+LI ILSW+SFWIN DA+ ARV LGITTVLTMTT ++  R +LPK+ YVKAI
Sbjct: 252 LIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAI 311

Query: 307 DMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGN 366
           D+++  C +FVF ALLEYA VN++   R  +   +   K    K D +        A+G 
Sbjct: 312 DIWMAVCLLFVFSALLEYAAVNFV--SRQHKELLRFRRKRRHHKEDEAGEGRFNFSAYG- 368

Query: 367 ILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKT 426
           +    L+  + ++       +T N   +   S  + RK  + R                 
Sbjct: 369 MGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQR----------------- 411

Query: 427 HLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471
                                ID+ SRI FP  F +FN+ YW+ Y
Sbjct: 412 ------------------AKKIDKISRIGFPMAFLIFNMFYWIIY 438


>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
           precursor [Homo sapiens]
          Length = 467

 Score =  285 bits (730), Expect = 5e-77
 Identities = 160/433 (36%), Positives = 240/433 (55%), Gaps = 38/433 (8%)

Query: 41  VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
           ++ LL+GYD +LRPD G  P  +  ++ + SI  V+ +NM+YT+ ++F Q W D+RL ++
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                L L++ +  ++W+PDT+F N KK+  H +T  NRM+R+  DG VLY LR+T  A 
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220
           C + L  +P+DE +C LE  SYGY  ++I + W+     V       L QFS V  R  +
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249

Query: 221 RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280
             V   +G Y  +S+ F L R +GYF +QTY+P  LI +LSWVSFWIN DA  AR +LGI
Sbjct: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309

Query: 281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340
           TTVLTMTT++T  R++LPK+ YV A+D+++  CF+FVF AL+EY  ++Y    R P + K
Sbjct: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369

Query: 341 KLAEKTAKAKND-RSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSG 399
              +K      D R +S + +++   ++     E   E  +      D  +    F++  
Sbjct: 370 DKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK----DCASFFCCFEDC- 424

Query: 400 IQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFT 459
                    R G  R        H + H+R               +  +D ++RI FP  
Sbjct: 425 ---------RTGAWR--------HGRIHIR---------------IAKMDSYARIFFPTA 452

Query: 460 FSLFNLVYWLYYV 472
           F LFNLVYW+ Y+
Sbjct: 453 FCLFNLVYWVSYL 465


>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
          Length = 417

 Score =  282 bits (721), Expect = 5e-76
 Identities = 142/317 (44%), Positives = 207/317 (65%), Gaps = 14/317 (4%)

Query: 19  GTRGSEPRSVNDPGNMSFVKETVDKLL---KGYDIRLRPDFGGPPVCVGMNIDIASIDMV 75
           GT+GS+P S +D          +DKL+    GYD R+RP+F GPPV V  NI I S   +
Sbjct: 35  GTKGSQPMSPSD---------FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSI 85

Query: 76  SEVNMDYTLTMYFQQYWRDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGV 134
           ++  MDY + ++ +Q W D RL+Y   P + L LD  + D +W PD +F N+K +  H V
Sbjct: 86  TKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEV 145

Query: 135 TVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWR 194
           T  N+++R+  +G VLY +R+T   +C+MDL+ +P+D Q CT+++ES+GYT  D+ F W 
Sbjct: 146 TTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWL 205

Query: 195 GGDKAVTGVERIELPQFSIVEHR-LVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMP 253
               AV   E + LPQF + + + L      + TG +  + + F L+R +GY+++Q Y+P
Sbjct: 206 EDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIP 265

Query: 254 SILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGC 313
           S+LI ILSWVSFWIN DA+ ARV LGITTVLTMTT ++  R +LPK+ YVKAID+++  C
Sbjct: 266 SLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVC 325

Query: 314 FVFVFLALLEYAFVNYI 330
            +FVF ALLEYA +N++
Sbjct: 326 LLFVFAALLEYAAINFV 342


>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
           precursor [Homo sapiens]
          Length = 462

 Score =  280 bits (716), Expect = 2e-75
 Identities = 167/481 (34%), Positives = 250/481 (51%), Gaps = 49/481 (10%)

Query: 1   MCSGLLELLLPIWLSWTLGTRGSEPRSVNDP--GNMSFVKETVDKLLKGYDIRLRPDFGG 58
           M   LL   + + LS   G       SV D    N++     +D LL GYD RLRP  G 
Sbjct: 11  MIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGE 70

Query: 59  PPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWV 118
               V  +I + S   VS+  M+YT+ ++F+Q W+D+RL + G    L L+N +A ++W 
Sbjct: 71  RITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWT 130

Query: 119 PDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLE 178
           PDT+F N KKS  H +T  N+++RL  DGT+LY +R+T +A C M L  +P+D   C L+
Sbjct: 131 PDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLK 190

Query: 179 IESYGYTTDDIEFYWRGGD--KAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLS 236
             SY Y   ++ + W  G     V   +   L Q+ ++   + + N+  +TG Y  ++  
Sbjct: 191 FGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAH 250

Query: 237 FRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRET 296
           F LKR IGYF++QTY+P I+  ILS VSFW+N ++  AR   G+TTVLTMTT++   R +
Sbjct: 251 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 310

Query: 297 LPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKS 356
           LPK+ Y  A+D ++  C+ FVF AL+E+A VNY F  RG     K A + AK K  R   
Sbjct: 311 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNY-FTKRGWAWDGKKALEAAKIKKKREVI 369

Query: 357 ESNRVDAHGNILLTSLEVHNEMN----EVSGGIGDTRNSAISFDNSGIQYRKQSMPREGH 412
            +   +A      T+ ++ +  N    +   G  +T + ++              P E  
Sbjct: 370 LNKSTNA-----FTTGKMSHPPNIPKEQTPAGTSNTTSVSVK-------------PSE-- 409

Query: 413 GRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
                +++   KKT+                 ++ ID+ SRIVFP  F  FNLVYW  Y+
Sbjct: 410 -----EKTSESKKTY---------------NSISKIDKMSRIVFPVLFGTFNLVYWATYL 449

Query: 473 N 473
           N
Sbjct: 450 N 450


>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
           [Homo sapiens]
          Length = 465

 Score =  279 bits (713), Expect = 5e-75
 Identities = 161/436 (36%), Positives = 237/436 (54%), Gaps = 36/436 (8%)

Query: 37  VKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKR 96
           + + ++ LL+GYD +LRPD G  P  +  ++ + SI  V  +NM+YT+ + F Q W D R
Sbjct: 64  ITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSR 123

Query: 97  LAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156
           L ++     L L++ +  ++W+PDT+F N +KS  H +T  NR++R+  DG VLY LR+T
Sbjct: 124 LKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLT 183

Query: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216
             A C + L  +P+DE +C LE  SYGY  ++IE+ W+     V   +   L QF+ V  
Sbjct: 184 INAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGL 243

Query: 217 RLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARV 276
           R  +      +G Y  +++ F L R +GYF +QTY+P IL  +LSWVSFWIN DA  AR 
Sbjct: 244 RNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPART 303

Query: 277 ALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGP 336
           +LGITTVLTMTT++T  R++LPK+ YV A+D+++  CF+FVF AL+EY  ++Y       
Sbjct: 304 SLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYF----TS 359

Query: 337 QRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFD 396
            ++ K A K  K KN  S +        G+ L+    +     +  G          SF 
Sbjct: 360 NQKGKTATKDRKLKNKASMTPGLH---PGSTLIPMNNISVPQEDDYGYQCLEGKDCASFF 416

Query: 397 NSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVF 456
                 R  S  REG             + H+R               +  ID +SRI F
Sbjct: 417 CCFEDCRTGSW-REG-------------RIHIR---------------IAKIDSYSRIFF 447

Query: 457 PFTFSLFNLVYWLYYV 472
           P  F+LFNLVYW+ Y+
Sbjct: 448 PTAFALFNLVYWVGYL 463


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score =  276 bits (707), Expect = 2e-74
 Identities = 163/444 (36%), Positives = 242/444 (54%), Gaps = 42/444 (9%)

Query: 33  NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92
           N++     +D+LL GYD RLRP  G     V  NI + S   VS+ +M+YT+ ++F+Q W
Sbjct: 38  NITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKW 97

Query: 93  RDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 151
           +D+RL + G P+N L L+N +A ++W PDT+F N KKS  H +T+ N+++R+  DGT+LY
Sbjct: 98  KDERLKFKG-PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLY 156

Query: 152 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW--RGGDKAVTGVERIELP 209
            +R+T  A C M L  +P+D  +C L+  SY YTT ++ + W     D      +   L 
Sbjct: 157 TMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLN 216

Query: 210 QFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINY 269
           Q+ ++   +    +  +TG Y  ++  F LKR IGYF++QTY+P I+  ILS VSFW+N 
Sbjct: 217 QYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNR 276

Query: 270 DASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY 329
           ++  AR   G+TTVLTMTT++   R +LPK+ Y  A+D ++  C+ FVF AL+E+A VNY
Sbjct: 277 ESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY 336

Query: 330 IFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTR 389
            F  RG       A       ND+ K +++ V    N    ++ V N    +S    D  
Sbjct: 337 -FTKRG------WAWDGKSVVNDKKKEKAS-VMIQNNAY--AVAVANYAPNLS---KDPV 383

Query: 390 NSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAID 449
            S IS        +  + P             P+KK   +   ++          V+ ID
Sbjct: 384 LSTIS--------KSATTPE------------PNKKPENKPAEAK-----KTFNSVSKID 418

Query: 450 RWSRIVFPFTFSLFNLVYWLYYVN 473
           R SRIVFP  F  FNLVYW  Y+N
Sbjct: 419 RMSRIVFPVLFGTFNLVYWATYLN 442


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score =  276 bits (707), Expect = 2e-74
 Identities = 163/444 (36%), Positives = 242/444 (54%), Gaps = 42/444 (9%)

Query: 33  NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92
           N++     +D+LL GYD RLRP  G     V  NI + S   VS+ +M+YT+ ++F+Q W
Sbjct: 38  NITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKW 97

Query: 93  RDKRLAYSGIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 151
           +D+RL + G P+N L L+N +A ++W PDT+F N KKS  H +T+ N+++R+  DGT+LY
Sbjct: 98  KDERLKFKG-PMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLY 156

Query: 152 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW--RGGDKAVTGVERIELP 209
            +R+T  A C M L  +P+D  +C L+  SY YTT ++ + W     D      +   L 
Sbjct: 157 TMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLN 216

Query: 210 QFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINY 269
           Q+ ++   +    +  +TG Y  ++  F LKR IGYF++QTY+P I+  ILS VSFW+N 
Sbjct: 217 QYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNR 276

Query: 270 DASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY 329
           ++  AR   G+TTVLTMTT++   R +LPK+ Y  A+D ++  C+ FVF AL+E+A VNY
Sbjct: 277 ESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY 336

Query: 330 IFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTR 389
            F  RG       A       ND+ K +++ V    N    ++ V N    +S    D  
Sbjct: 337 -FTKRG------WAWDGKSVVNDKKKEKAS-VMIQNNAY--AVAVANYAPNLS---KDPV 383

Query: 390 NSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAID 449
            S IS        +  + P             P+KK   +   ++          V+ ID
Sbjct: 384 LSTIS--------KSATTPE------------PNKKPENKPAEAK-----KTFNSVSKID 418

Query: 450 RWSRIVFPFTFSLFNLVYWLYYVN 473
           R SRIVFP  F  FNLVYW  Y+N
Sbjct: 419 RMSRIVFPVLFGTFNLVYWATYLN 442


>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
           [Homo sapiens]
          Length = 492

 Score =  276 bits (707), Expect = 2e-74
 Identities = 159/446 (35%), Positives = 239/446 (53%), Gaps = 33/446 (7%)

Query: 33  NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92
           N++     +D+LL GYD RLRP  G     V  +I + S   VS+ +M+YT+ ++F+Q W
Sbjct: 63  NITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTW 122

Query: 93  RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152
            D+RL + G    L L+N +A ++W PDT+F N KKS  H +T  N+++RL  +GT+LY 
Sbjct: 123 HDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYT 182

Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWR-GGDKAV-TGVERIELPQ 210
           +R+T  A C M L  +P+D   C L+  SY YTT ++ + W  G +K+V    +   L Q
Sbjct: 183 MRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQ 242

Query: 211 FSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYD 270
           + ++ H + +  +  +TG Y  ++  F LKR IGYF++QTY+P I+  ILS VSFW+N +
Sbjct: 243 YDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 302

Query: 271 ASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYI 330
           +  AR   G+TTVLTMTT++   R +LPK+ Y  A+D ++  C+ FVF AL+E+A VNY 
Sbjct: 303 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYF 362

Query: 331 FFGRGPQRQKKLAEKTAKAKND---RSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGD 387
                    KK+ E     K      +K  S   +  G     +L    E + +S G   
Sbjct: 363 TKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAP 422

Query: 388 TRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNA 447
           + +S  +   S      Q  P E              KT+                 V+ 
Sbjct: 423 SASSTPTIIASPKATYVQDSPTE-------------TKTY---------------NSVSK 454

Query: 448 IDRWSRIVFPFTFSLFNLVYWLYYVN 473
           +D+ SRI+FP  F++FNLVYW  YVN
Sbjct: 455 VDKISRIIFPVLFAIFNLVYWATYVN 480


>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
           [Homo sapiens]
          Length = 467

 Score =  271 bits (692), Expect = 1e-72
 Identities = 153/432 (35%), Positives = 237/432 (54%), Gaps = 17/432 (3%)

Query: 41  VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
           ++KLL+ YD +LRPD G  P  + ++I + SI  VS +NM+Y + ++F Q W D RL ++
Sbjct: 51  LNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFN 110

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                LTL++ +   +W+PDT F N K +  H +T  N+++R+  DG +LY LR+T  A 
Sbjct: 111 STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170

Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220
           C + L  +P+DE +C L   SYGY  +++ + WR         +   L QF  +  R  +
Sbjct: 171 CQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTT 230

Query: 221 RNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 280
             V  + G Y  +++ F L R +GYF +QTY+P IL  +LSWVSFWI  DA+ AR ALGI
Sbjct: 231 EIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGI 290

Query: 281 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQK 340
           TTVLTMTT++T  R++LP++ YV A+D+++  CF+FVF AL+EYA +NY    R P   K
Sbjct: 291 TTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTK 350

Query: 341 KLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGI 400
           K    T+    D S+    R+        + L++      +      T N+++ +     
Sbjct: 351 K---TTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMI-----TLNNSVYWQEFED 402

Query: 401 QYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTF 460
               + +  +    F        +      R  ++ I I +L      D +SR+ FP +F
Sbjct: 403 TCVYECLDGKDCQSFF---CCYEECKSGSWRKGRIHIDILEL------DSYSRVFFPTSF 453

Query: 461 SLFNLVYWLYYV 472
            LFNLVYW+ Y+
Sbjct: 454 LLFNLVYWVGYL 465


>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
           [Homo sapiens]
          Length = 554

 Score =  268 bits (684), Expect = 1e-71
 Identities = 167/493 (33%), Positives = 256/493 (51%), Gaps = 61/493 (12%)

Query: 41  VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
           +D LL GYD RLRP FGGP   V  +I + S   VS+V M+YT+ ++F+Q W DKRL Y 
Sbjct: 52  LDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
           G    L L+N +  ++W PDT+F N KKS  H +T  N++ R+  +GT+LY +R+T +A 
Sbjct: 112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAE 171

Query: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW-RGGDKAV-TGVERIELPQFSIVEHRL 218
           C M L  +P+D   C L+  SY Y   ++ + W +G +K+V    E   L Q+ ++   +
Sbjct: 172 CPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTV 231

Query: 219 VSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVAL 278
            S  +   TG Y  +++ F L+R +GYF++QTY+P I+  ILS VSFWIN ++  AR   
Sbjct: 232 SSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVF 291

Query: 279 GITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY---IFFGRG 335
           GITTVLTMTT++   R +LPK+ Y  A+D ++  CF FVF AL+E+A VNY   I   + 
Sbjct: 292 GITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKA 351

Query: 336 PQRQKKLAEKTAKAKNDRSK-SESNRVDAHGNILL---TSLEVHNEM---NEVSGGIGDT 388
            ++  K  ++   A   R K  E+   + + N+ +   T+  VH+E    N    G   +
Sbjct: 352 KRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSS 411

Query: 389 RNSAISFDNS----------------------------------------GIQYRKQSMP 408
           ++S +  ++S                                        G   RK S+ 
Sbjct: 412 KSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVG 471

Query: 409 REGHGRFLGDRSLPHKKTHLRRRSSQLKIKI--------PDLTDVNAIDRWSRIVFPFTF 460
                   G R L   KT +    +  K+          P  +  + ID+++RI+FP TF
Sbjct: 472 SASTRHVFGSR-LQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTF 530

Query: 461 SLFNLVYWLYYVN 473
             FN+VYW+ Y++
Sbjct: 531 GAFNMVYWVVYLS 543


>gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3
           precursor [Homo sapiens]
          Length = 515

 Score =  265 bits (677), Expect = 7e-71
 Identities = 157/477 (32%), Positives = 238/477 (49%), Gaps = 78/477 (16%)

Query: 41  VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
           ++ LL+GYD +LRPD G  P  +  ++ + SI  V+ +NM+YT+ ++F Q W D+RL ++
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
                L L++ +  ++W+PDT+F N KK+  H +T  NRM+R+  DG VLY LR+T  A 
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 161 CMMDLRRYPLDEQNCTLEIESY-------------------------------------- 182
           C + L  +P+DE +C LE  S+                                      
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249

Query: 183 --GYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240
             GY  ++I + W+     V       L QFS V  R  +  V   +G Y  +S+ F L 
Sbjct: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 309

Query: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300
           R +GYF +QTY+P  LI +LSWVSFWIN DA  AR +LGITTVLTMTT++T  R++LPK+
Sbjct: 310 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKV 369

Query: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360
            YV A+D+++  CF+FVF AL+EY  ++Y    R P + K   +K    +    K+ +  
Sbjct: 370 SYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTID 429

Query: 361 VDAHGNILLTSLEVHNEMNEVSGGI-----GDTRNSAISFDNSGIQYRKQSMPREGHGRF 415
           +      +  +   H +  +   G       D  +    F++           R G  R 
Sbjct: 430 IRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDC----------RTGAWR- 478

Query: 416 LGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
                  H + H+R               +  +D ++RI FP  F LFNLVYW+ Y+
Sbjct: 479 -------HGRIHIR---------------IAKMDSYARIFFPTAFCLFNLVYWVSYL 513


>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
           precursor [Homo sapiens]
          Length = 456

 Score =  265 bits (677), Expect = 7e-71
 Identities = 158/445 (35%), Positives = 232/445 (52%), Gaps = 42/445 (9%)

Query: 33  NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92
           N +     +D+LL GYD RLRP  G     V  +I + S   VS+ +M+YT+ ++F+Q W
Sbjct: 38  NTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSW 97

Query: 93  RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152
           +D+RL + G    L L+N +A ++W PDT+F N KKS  H +T+ N+++R+  DGT+LY 
Sbjct: 98  KDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYT 157

Query: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW--RGGDKAVTGVERIELPQ 210
           +R+T  A C M L  +P+D   C L+  SY YT  ++ + W        V   +   L Q
Sbjct: 158 MRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQ 217

Query: 211 FSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYD 270
           + ++   + S  V  +TG Y  ++  F LKR IGYF++QTY+P I+  ILS VSFW+N +
Sbjct: 218 YDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 277

Query: 271 ASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYI 330
           +  AR   G+TTVLTMTT++   R +LPK+ Y  A+D ++  C+ FVF AL+E+A VNY 
Sbjct: 278 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY- 336

Query: 331 FFGRGPQRQKK--LAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDT 388
           F  RG     K  + EK  K K+   K  +           T+      +     G+   
Sbjct: 337 FTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP-------TATSYTPNLARGDPGLATI 389

Query: 389 RNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAI 448
             SA        + + ++ P E             KKT                  V+ I
Sbjct: 390 AKSATIEPK---EVKPETKPPE------------PKKT---------------FNSVSKI 419

Query: 449 DRWSRIVFPFTFSLFNLVYWLYYVN 473
           DR SRI FP  F +FNLVYW  Y+N
Sbjct: 420 DRLSRIAFPLLFGIFNLVYWATYLN 444


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,757,288
Number of Sequences: 37866
Number of extensions: 683233
Number of successful extensions: 1690
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1510
Number of HSP's gapped (non-prelim): 117
length of query: 473
length of database: 18,247,518
effective HSP length: 106
effective length of query: 367
effective length of database: 14,233,722
effective search space: 5223775974
effective search space used: 5223775974
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.