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Search of human proteins with 38373677
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38373677 guanine nucleotide-releasing factor 2 isoform b
[Homo sapiens]
(1095 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 2196 0.0
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 2151 0.0
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 142 2e-33
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 142 2e-33
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 142 2e-33
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 135 2e-31
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 135 2e-31
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 129 2e-29
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 123 1e-27
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 123 1e-27
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 112 3e-24
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 109 2e-23
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 109 2e-23
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 108 2e-23
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 107 6e-23
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 107 6e-23
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 107 6e-23
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 105 2e-22
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 105 2e-22
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 103 9e-22
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 102 2e-21
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 99 2e-20
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 98 4e-20
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 93 1e-18
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 93 1e-18
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 93 1e-18
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 93 2e-18
gi|23957680 ral guanine nucleotide dissociation stimulator-like ... 92 3e-18
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 91 8e-18
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 89 2e-17
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 2196 bits (5691), Expect = 0.0
Identities = 1095/1095 (100%), Positives = 1095/1095 (100%)
Query: 1 MGNAIEKQKPLKRSHLYPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVK 60
MGNAIEKQKPLKRSHLYPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVK
Sbjct: 1 MGNAIEKQKPLKRSHLYPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVK 60
Query: 61 IPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVS 120
IPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVS
Sbjct: 61 IPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVS 120
Query: 121 ALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSL 180
ALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSL
Sbjct: 121 ALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSL 180
Query: 181 ANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPS 240
ANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPS
Sbjct: 181 ANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPS 240
Query: 241 SPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSP 300
SPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSP
Sbjct: 241 SPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSP 300
Query: 301 PPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYG 360
PPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYG
Sbjct: 301 PPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYG 360
Query: 361 GESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQ 420
GESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQ
Sbjct: 361 GESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQ 420
Query: 421 IPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRR 480
IPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRR
Sbjct: 421 IPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRR 480
Query: 481 SAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPV 540
SAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPV
Sbjct: 481 SAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPV 540
Query: 541 EFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQK 600
EFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQK
Sbjct: 541 EFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQK 600
Query: 601 NKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDS 660
NKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDS
Sbjct: 601 NKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDS 660
Query: 661 RDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLV 720
RDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLV
Sbjct: 661 RDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLV 720
Query: 721 HATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVL 780
HATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVL
Sbjct: 721 HATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVL 780
Query: 781 VRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQ 840
VRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQ
Sbjct: 781 VRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQ 840
Query: 841 PLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQF 900
PLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQF
Sbjct: 841 PLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQF 900
Query: 901 TEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIR 960
TEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIR
Sbjct: 901 TEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIR 960
Query: 961 RLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDY 1020
RLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDY
Sbjct: 961 RLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDY 1020
Query: 1021 IDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIK 1080
IDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIK
Sbjct: 1021 IDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIK 1080
Query: 1081 PRNITRRKTDREEKT 1095
PRNITRRKTDREEKT
Sbjct: 1081 PRNITRRKTDREEKT 1095
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 2151 bits (5574), Expect = 0.0
Identities = 1074/1074 (100%), Positives = 1074/1074 (100%)
Query: 22 DSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPL 81
DSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPL
Sbjct: 4 DSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPL 63
Query: 82 PLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEM 141
PLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEM
Sbjct: 64 PLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEM 123
Query: 142 LPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKE 201
LPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKE
Sbjct: 124 LPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKE 183
Query: 202 MVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEI 261
MVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEI
Sbjct: 184 MVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEI 243
Query: 262 LNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVV 321
LNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVV
Sbjct: 244 LNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVV 303
Query: 322 APMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQ 381
APMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQ
Sbjct: 304 APMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQ 363
Query: 382 LSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGS 441
LSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGS
Sbjct: 364 LSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGS 423
Query: 442 PFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPS 501
PFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPS
Sbjct: 424 PFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPS 483
Query: 502 QYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPL 561
QYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPL
Sbjct: 484 QYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPL 543
Query: 562 PEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQ 621
PEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQ
Sbjct: 544 PEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQ 603
Query: 622 ELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEE 681
ELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEE
Sbjct: 604 ELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEE 663
Query: 682 EVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTY 741
EVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTY
Sbjct: 664 EVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTY 723
Query: 742 RTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLM 801
RTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLM
Sbjct: 724 RTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLM 783
Query: 802 ELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHE 861
ELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHE
Sbjct: 784 ELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHE 843
Query: 862 IAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKA 921
IAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKA
Sbjct: 844 IAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKA 903
Query: 922 QDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDS 981
QDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDS
Sbjct: 904 QDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDS 963
Query: 982 SSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMR 1041
SSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMR
Sbjct: 964 SSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMR 1023
Query: 1042 CFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT 1095
CFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
Sbjct: 1024 CFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT 1077
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 142 bits (357), Expect = 2e-33
Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)
Query: 844 ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 901
A GV A P H + EIAEQLTLLD +F KI E W K + E++P + + T
Sbjct: 1010 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 1067
Query: 902 EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 961
+HFN++S + S I+ E R + K++ + R L+N+N+ L I S+++ + I R
Sbjct: 1068 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 1127
Query: 962 LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 1016
L+ W KQT + + L+ S F+ R AL +PPC+PYLG+ L DL F+ G
Sbjct: 1128 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 1187
Query: 1017 NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1075
P+Y DG VNFSK +I+ +R FQQ Y + + + D S + EE+L+E
Sbjct: 1188 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 1247
Query: 1076 SLKIKPR 1082
SL+I+P+
Sbjct: 1248 SLRIEPK 1254
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 142 bits (357), Expect = 2e-33
Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)
Query: 844 ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 901
A GV A P H + EIAEQLTLLD +F KI E W K + E++P + + T
Sbjct: 1026 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 1083
Query: 902 EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 961
+HFN++S + S I+ E R + K++ + R L+N+N+ L I S+++ + I R
Sbjct: 1084 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 1143
Query: 962 LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 1016
L+ W KQT + + L+ S F+ R AL +PPC+PYLG+ L DL F+ G
Sbjct: 1144 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 1203
Query: 1017 NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1075
P+Y DG VNFSK +I+ +R FQQ Y + + + D S + EE+L+E
Sbjct: 1204 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 1263
Query: 1076 SLKIKPR 1082
SL+I+P+
Sbjct: 1264 SLRIEPK 1270
>gi|24797101 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 2 [Homo sapiens]
Length = 489
Score = 142 bits (357), Expect = 2e-33
Identities = 91/247 (36%), Positives = 136/247 (55%), Gaps = 10/247 (4%)
Query: 844 ARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFT 901
A GV A P H + EIAEQLTLLD +F KI E W K + E++P + + T
Sbjct: 242 AEGVKAEPFENHS--ALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTT 299
Query: 902 EHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 961
+HFN++S + S I+ E R + K++ + R L+N+N+ L I S+++ + I R
Sbjct: 300 KHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFR 359
Query: 962 LE--W---QKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLG 1016
L+ W KQT + + L+ S F+ R AL +PPC+PYLG+ L DL F+ G
Sbjct: 360 LKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG 419
Query: 1017 NPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWEL 1075
P+Y DG VNFSK +I+ +R FQQ Y + + + D S + EE+L+E
Sbjct: 420 TPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYES 479
Query: 1076 SLKIKPR 1082
SL+I+P+
Sbjct: 480 SLRIEPK 486
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 135 bits (341), Expect = 2e-31
Identities = 111/401 (27%), Positives = 184/401 (45%), Gaps = 53/401 (13%)
Query: 733 YCEAFLTTYRTFISPEELIKKLQYRYEKFSPF-ADTFKKRVSK----------------- 774
+ FLTTYR+F P+EL+ L R+E P D K + K
Sbjct: 621 FVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYV 680
Query: 775 --------NTF--FVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNIL 824
N F +V D +EL E + + + + + S+A+++R+
Sbjct: 681 QPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQ 740
Query: 825 DKVDQKKLLRCATSSQPLAARGVAARPGTLHDF-----HSHEIAEQLTLLDAELFYKIEI 879
+ + S P ++PG F H EIA QLTLL+++L+ K++
Sbjct: 741 AQANGVSH-NITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQP 799
Query: 880 PEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKH 937
E++ +W KE E SPNL + H N++ W I+ E ++R +L + I+I++
Sbjct: 800 SELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQV 859
Query: 938 LRKLNNFNSYLAILSALDSAPIRRLE-----WQKQTSEGLAEYCTLIDSSSSFRAYRAAL 992
+ LNNFN L I+SA++S + RL+ Q++ + L E L S F+ Y L
Sbjct: 860 FQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL--SQDHFKKYLVKL 917
Query: 993 SEVEPPCIPYLGLILQDLTFVHLGNPDYIDGK----VNFSKRWQQFNILDSMRCFQQAHY 1048
+ PPC+P+ G+ L ++ GN D++ K +NFSKR + I ++ +Q Y
Sbjct: 918 KSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPY 977
Query: 1049 DMRRNDDIINFFNDF------SDHLAEEALWELSLKIKPRN 1083
+R D+ FF + S+ + L+ SL+I+PRN
Sbjct: 978 CLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRN 1018
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 135 bits (340), Expect = 2e-31
Identities = 111/403 (27%), Positives = 185/403 (45%), Gaps = 57/403 (14%)
Query: 733 YCEAFLTTYRTFISPEELIKKLQYRYEKFSPF---ADTFK------------KRVSKNTF 777
+ FLTTYR+F P+EL+ + R+E P AD KR K
Sbjct: 623 FVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYI 682
Query: 778 FVLVRVVDELCLVELTEEILKL-----LMELVFRLVCNGELSLARVLRKNILDKVDQKKL 832
+ V +C + L++ + + + ++I + +KK+
Sbjct: 683 QPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKI 742
Query: 833 LR-------CATSSQPLAARGVAARPGTLHDF-----HSHEIAEQLTLLDAELFYKIEIP 880
R S P +RPG + F H EIA QLTLL+++L+ ++
Sbjct: 743 ARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPS 802
Query: 881 EVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHL 938
E++ +W KE E SPNL + H N++ W I+ E ++R ++ + I+I++
Sbjct: 803 ELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVF 862
Query: 939 RKLNNFNSYLAILSALDSAPIRRLEW--------QKQTSEGLAEYCTLIDSSSSFRAYRA 990
++LNNFN L ++SA++S+P+ RL+ QK+ E E S ++ Y A
Sbjct: 863 QELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL-----SEDHYKKYLA 917
Query: 991 ALSEVEPPCIPYLGLILQDLTFVHLGNPDYI--DGK--VNFSKRWQQFNILDSMRCFQQA 1046
L + PPC+P+ G+ L ++ GNP+ + GK +NFSKR + I ++ +Q
Sbjct: 918 KLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQ 977
Query: 1047 HYDMRRNDDIINFF---NDFSDHLAEE---ALWELSLKIKPRN 1083
Y +R DI FF N + + +E L+ SL+I+PRN
Sbjct: 978 PYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN 1020
Score = 34.7 bits (78), Expect = 0.51
Identities = 58/272 (21%), Positives = 98/272 (36%), Gaps = 57/272 (20%)
Query: 428 NLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTA 487
NL+P+ S+ + + +L F L P+ PL P P+K S
Sbjct: 993 NLNPMGNSMEKEFTDYL---FNKSLEIEPRNPKPL---------PRFPKKYSYPLKSPGV 1040
Query: 488 DGSGCRVSYERHPS---------QYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSA 538
S R RHP+ Y I + +STA P+ P P + P G+S+
Sbjct: 1041 RPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTP---LTPPPASGASS 1097
Query: 539 PVE----FVGDFTAP-ESTGDPE----KPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQ 589
+ F D ++P S+ D P P + ++ + ++ P P +
Sbjct: 1098 TTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPPPVPPRR 1157
Query: 590 TPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPR-- 647
P++ +K++ + L PPA+PP+Q P K PR
Sbjct: 1158 RPESAPAESSPSKIMSK---------------HLDSPPAIPPRQ-----PTSKAYSPRYS 1197
Query: 648 --DPSAVSGVPGKDSRDGSERAPKSPDALESA 677
D +++S P ++PD S+
Sbjct: 1198 ISDRTSISDPPESPPLLPPREPVRTPDVFSSS 1229
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 129 bits (324), Expect = 2e-29
Identities = 82/230 (35%), Positives = 121/230 (52%), Gaps = 8/230 (3%)
Query: 861 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 918
E+AEQ+TLLD +F I E L W K E++P + + ++HFN+MS V S IM
Sbjct: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
Query: 919 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--W---QKQTSEGLA 973
R + K++ + R L+N+N L I SAL+ + I RL+ W KQT +
Sbjct: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
Query: 974 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQ 1032
+ + S F+ R L PP +PYLG+ L DL F+ G P++ +G VNFSK
Sbjct: 1125 KLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRM 1184
Query: 1033 QFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPR 1082
+I+ +R FQQ Y + + + D + E+ L+ELSLKI+PR
Sbjct: 1185 ISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPR 1234
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform b
[Homo sapiens]
Length = 867
Score = 123 bits (308), Expect = 1e-27
Identities = 74/244 (30%), Positives = 132/244 (54%), Gaps = 13/244 (5%)
Query: 852 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSY 909
GT S ++A Q+T+ D ELF + E++ + + ++ + NL F FN + +
Sbjct: 622 GTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF 681
Query: 910 WVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQ 967
WV + I L + R +LL KFIKI H ++ N NS+ AI+ L + + RL W+K
Sbjct: 682 WVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKL 741
Query: 968 TSEG---LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGK 1024
S+ AE+ +L+D S + RAYR ++++EPP IP++ L+++D+TF H GN +ID
Sbjct: 742 PSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNL 801
Query: 1025 VNFSKRWQQFNILDSMRCFQQAHYD------MRRNDDIINFFNDFSDHLAEEALWELSLK 1078
VNF K N ++R ++ ++ + + D+ ++ + + L ++S +
Sbjct: 802 VNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR 861
Query: 1079 IKPR 1082
++PR
Sbjct: 862 LEPR 865
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 123 bits (308), Expect = 1e-27
Identities = 74/244 (30%), Positives = 132/244 (54%), Gaps = 13/244 (5%)
Query: 852 GTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSY 909
GT S ++A Q+T+ D ELF + E++ + + ++ + NL F FN + +
Sbjct: 766 GTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQF 825
Query: 910 WVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQ 967
WV + I L + R +LL KFIKI H ++ N NS+ AI+ L + + RL W+K
Sbjct: 826 WVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKL 885
Query: 968 TSEG---LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGK 1024
S+ AE+ +L+D S + RAYR ++++EPP IP++ L+++D+TF H GN +ID
Sbjct: 886 PSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNL 945
Query: 1025 VNFSKRWQQFNILDSMRCFQQAHYD------MRRNDDIINFFNDFSDHLAEEALWELSLK 1078
VNF K N ++R ++ ++ + + D+ ++ + + L ++S +
Sbjct: 946 VNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR 1005
Query: 1079 IKPR 1082
++PR
Sbjct: 1006 LEPR 1009
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 112 bits (279), Expect = 3e-24
Identities = 71/232 (30%), Positives = 131/232 (56%), Gaps = 10/232 (4%)
Query: 861 EIAEQLTLLDAELFYKIEIPEVLLW--AKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 918
++A +L D LF I E++ + +++ + E + NL+ + N + WV + I+L
Sbjct: 498 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557
Query: 919 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLA 973
+ R +L+ KFIKI H + N NS+ AI+ L++A + RL W+K + + +
Sbjct: 558 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617
Query: 974 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1033
E +L D S + +AYR A +++PP IP++ L+L+D+TF+H GN ++D VNF K
Sbjct: 618 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMI 677
Query: 1034 FNILDSMR-CFQQAHYDM--RRNDDIINFFNDFSDHLAEEALWELSLKIKPR 1082
+ + ++R C D+ + + ++ ++ N +++AL+ELS +I+PR
Sbjct: 678 ADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPR 729
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 109 bits (272), Expect = 2e-23
Identities = 92/364 (25%), Positives = 170/364 (46%), Gaps = 24/364 (6%)
Query: 738 LTTYRTFISPEELIKKLQYRYEKFS-PFADTFKKRVSKNTFFVLVRVVDE----LCLVEL 792
L +R ++S EL +KL Y + + F+ ++ + +++ E L L+ +
Sbjct: 39 LLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRM 98
Query: 793 TEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPG 852
TEE ++ +L + +SL + + +R T + ++ +G A
Sbjct: 99 TEEFREVASQLGYEK----HVSLIDI------SSIPSYDWMRRVTQRKKVSKKGKACL-- 146
Query: 853 TLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVR 912
E+AE LT L+ + F +I + + E +P L + FN +S WV+
Sbjct: 147 LFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQ 206
Query: 913 SIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE-----WQKQ 967
+++ + Q R ++ KFI + K L +L NFN+ +A++ L + I RL+ +
Sbjct: 207 LMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSE 266
Query: 968 TSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVN 1026
++ E L+ S+ ++ YR A ++ + IP LG+ L+DL VH+ PD+ + KVN
Sbjct: 267 VTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVN 326
Query: 1027 FSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRNIT 1085
K Q L + Q A + + N D+IN D + E+ +++LSL ++PRN
Sbjct: 327 IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386
Query: 1086 RRKT 1089
+ T
Sbjct: 387 SQPT 390
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 109 bits (272), Expect = 2e-23
Identities = 92/364 (25%), Positives = 170/364 (46%), Gaps = 24/364 (6%)
Query: 738 LTTYRTFISPEELIKKLQYRYEKFS-PFADTFKKRVSKNTFFVLVRVVDE----LCLVEL 792
L +R ++S EL +KL Y + + F+ ++ + +++ E L L+ +
Sbjct: 39 LLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRM 98
Query: 793 TEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPG 852
TEE ++ +L + +SL + + +R T + ++ +G A
Sbjct: 99 TEEFREVASQLGYEK----HVSLIDI------SSIPSYDWMRRVTQRKKVSKKGKACL-- 146
Query: 853 TLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVR 912
E+AE LT L+ + F +I + + E +P L + FN +S WV+
Sbjct: 147 LFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQ 206
Query: 913 SIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE-----WQKQ 967
+++ + Q R ++ KFI + K L +L NFN+ +A++ L + I RL+ +
Sbjct: 207 LMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSE 266
Query: 968 TSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVN 1026
++ E L+ S+ ++ YR A ++ + IP LG+ L+DL VH+ PD+ + KVN
Sbjct: 267 VTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVN 326
Query: 1027 FSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRNIT 1085
K Q L + Q A + + N D+IN D + E+ +++LSL ++PRN
Sbjct: 327 IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386
Query: 1086 RRKT 1089
+ T
Sbjct: 387 SQPT 390
>gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
isoform 2 [Homo sapiens]
Length = 689
Score = 108 bits (271), Expect = 2e-23
Identities = 91/358 (25%), Positives = 168/358 (46%), Gaps = 24/358 (6%)
Query: 738 LTTYRTFISPEELIKKLQYRYEKFS-PFADTFKKRVSKNTFFVLVRVVDE----LCLVEL 792
L +R ++S EL +KL Y + + F+ ++ + +++ E L L+ +
Sbjct: 39 LLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRM 98
Query: 793 TEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPG 852
TEE ++ +L + +SL + + +R T + ++ +G A
Sbjct: 99 TEEFREVASQLGYEK----HVSLIDI------SSIPSYDWMRRVTQRKKVSKKGKACL-- 146
Query: 853 TLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVR 912
E+AE LT L+ + F +I + + E +P L + FN +S WV+
Sbjct: 147 LFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQ 206
Query: 913 SIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE-----WQKQ 967
+++ + Q R ++ KFI + K L +L NFN+ +A++ L + I RL+ +
Sbjct: 207 LMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSE 266
Query: 968 TSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVN 1026
++ E L+ S+ ++ YR A ++ + IP LG+ L+DL VH+ PD+ + KVN
Sbjct: 267 VTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVN 326
Query: 1027 FSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRN 1083
K Q L + Q A + + N D+IN D + E+ +++LSL ++PRN
Sbjct: 327 IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRN 384
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b [Homo
sapiens]
Length = 881
Score = 107 bits (267), Expect = 6e-23
Identities = 60/177 (33%), Positives = 100/177 (56%), Gaps = 8/177 (4%)
Query: 861 EIAEQLTLLDAELF---YKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 917
++A QLT D LF +++E+ +L + + + NL +F FN + YWV + + L
Sbjct: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682
Query: 918 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EWQKQTSEGLAEY 975
R +LL KFIK+ HL++ N NS+ A++ L ++ I RL W++ + Y
Sbjct: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742
Query: 976 CT---LIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
L+D S + R YR AL+++ PP IP++ L+L+D+TF+H GN ++ +NF K
Sbjct: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEK 799
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [Homo
sapiens]
Length = 881
Score = 107 bits (267), Expect = 6e-23
Identities = 60/177 (33%), Positives = 100/177 (56%), Gaps = 8/177 (4%)
Query: 861 EIAEQLTLLDAELF---YKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 917
++A QLT D LF +++E+ +L + + + NL +F FN + YWV + + L
Sbjct: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682
Query: 918 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EWQKQTSEGLAEY 975
R +LL KFIK+ HL++ N NS+ A++ L ++ I RL W++ + Y
Sbjct: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742
Query: 976 CT---LIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
L+D S + R YR AL+++ PP IP++ L+L+D+TF+H GN ++ +NF K
Sbjct: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEK 799
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a [Homo
sapiens]
Length = 923
Score = 107 bits (267), Expect = 6e-23
Identities = 60/177 (33%), Positives = 100/177 (56%), Gaps = 8/177 (4%)
Query: 861 EIAEQLTLLDAELF---YKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 917
++A QLT D LF +++E+ +L + + + NL +F FN + YWV + + L
Sbjct: 665 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 724
Query: 918 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EWQKQTSEGLAEY 975
R +LL KFIK+ HL++ N NS+ A++ L ++ I RL W++ + Y
Sbjct: 725 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 784
Query: 976 CT---LIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
L+D S + R YR AL+++ PP IP++ L+L+D+TF+H GN ++ +NF K
Sbjct: 785 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEK 841
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens]
Length = 762
Score = 105 bits (263), Expect = 2e-22
Identities = 86/356 (24%), Positives = 161/356 (45%), Gaps = 12/356 (3%)
Query: 735 EAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTE 794
+ LT +R IS EL++K+ Y+ A K +FV + + + ++
Sbjct: 87 QVMLTMHRIVISSAELLQKVITLYK--DALAKNSPGLCLKICYFVRYWITEFWVMFKMDA 144
Query: 795 EILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTL 854
+ + E + GE R++ ++ D + L S R V+
Sbjct: 145 SLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSL---LF 201
Query: 855 HDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSI 914
E++E LT L+ + F +I + + +++P + + N +S WV+ +
Sbjct: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 915 IMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQK-----QTS 969
++ + Q R + +KFI++ + L +L NFN+ +A++ L + I RL+ + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 970 EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFS 1028
+ L E L+ SS ++ YR A E IP LG+ L+DL ++ PDY+ DGKVN
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 1029 KRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRN 1083
K +N + + Q+ + N D+++ D + E+ ++ELS +PRN
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRN 437
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens]
Length = 797
Score = 105 bits (263), Expect = 2e-22
Identities = 86/356 (24%), Positives = 161/356 (45%), Gaps = 12/356 (3%)
Query: 735 EAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTE 794
+ LT +R IS EL++K+ Y+ A K +FV + + + ++
Sbjct: 87 QVMLTMHRIVISSAELLQKVITLYK--DALAKNSPGLCLKICYFVRYWITEFWVMFKMDA 144
Query: 795 EILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTL 854
+ + E + GE R++ ++ D + L S R V+
Sbjct: 145 SLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSL---LF 201
Query: 855 HDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSI 914
E++E LT L+ + F +I + + +++P + + N +S WV+ +
Sbjct: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 915 IMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQK-----QTS 969
++ + Q R + +KFI++ + L +L NFN+ +A++ L + I RL+ + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 970 EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFS 1028
+ L E L+ SS ++ YR A E IP LG+ L+DL ++ PDY+ DGKVN
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 1029 KRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRN 1083
K +N + + Q+ + N D+++ D + E+ ++ELS +PRN
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRN 437
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 103 bits (257), Expect = 9e-22
Identities = 79/249 (31%), Positives = 118/249 (47%), Gaps = 18/249 (7%)
Query: 861 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 918
E A Q+TL+D +F I+ E+ W K++ +PN FT FN++S+WV I+
Sbjct: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
Query: 919 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW------QKQTSE 970
+ + R +L +IK K L +LNN ++ +A++S L SAPI RL W K T E
Sbjct: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
Query: 971 GLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKR 1030
L + D+ R Y ++L PCIPYLG+ L DLT++ P N +
Sbjct: 172 KLEYVMSKEDNYKRLRDYISSLKMT--PCIPYLGIYLSDLTYIDSAYPSTGSILENEQRS 229
Query: 1031 WQQFNILDSMRCFQQA-HYDMRRNDDIINFFNDFS-----DHLAEEALWELSLKIKPRNI 1084
NIL + QQ+ YD+ + + N E+ ++LSLKI+P
Sbjct: 230 NLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTS 289
Query: 1085 TRRKTDREE 1093
T R E
Sbjct: 290 TPRSAASRE 298
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 102 bits (255), Expect = 2e-21
Identities = 65/177 (36%), Positives = 97/177 (54%), Gaps = 8/177 (4%)
Query: 861 EIAEQLTLLDAELFYKIEIPEVLL-WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQE 919
E+A QL++ + ELF IE E + K +++ NL +F E N ++WV S I+ +
Sbjct: 720 EVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRET 779
Query: 920 KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLAE 974
R +++ FIKI H R+ NFNS AI+S L+ AP+ RL W+K + + +
Sbjct: 780 NQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQD 839
Query: 975 YCTLIDSSSSFRAYRAALS--EVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
L D S + YR L+ ++PP IP +I +DLTF+H GN +DG VNF K
Sbjct: 840 LQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEK 896
Score = 32.7 bits (73), Expect = 1.9
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 6/76 (7%)
Query: 680 EEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLT 739
EEE + + + +H E+ T K G V G+ + L +H E + E FL
Sbjct: 246 EEEGEIVMVKEHRELDRTGTRK-----GHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL 300
Query: 740 TYRTFI-SPEELIKKL 754
TYRTF+ SP E+ KKL
Sbjct: 301 TYRTFLSSPMEVGKKL 316
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 99.0 bits (245), Expect = 2e-20
Identities = 62/177 (35%), Positives = 97/177 (54%), Gaps = 8/177 (4%)
Query: 861 EIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEK-SPNLTQFTEHFNNMSYWVRSIIMLQE 919
E+A QL++ D +LF IE E + + N + + +L +F + N ++WV S I+ +
Sbjct: 863 EVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEA 922
Query: 920 KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTS---EGLAE 974
R +++ FIKI H R+ NFNS AI+S L+ A + RL W+K S + L +
Sbjct: 923 NQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQD 982
Query: 975 YCTLIDSSSSFRAYRAALS--EVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
+ D S + YR LS ++PP IP ++ +D+TF+H GN +DG VNF K
Sbjct: 983 LQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEK 1039
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 98.2 bits (243), Expect = 4e-20
Identities = 79/252 (31%), Positives = 123/252 (48%), Gaps = 23/252 (9%)
Query: 861 EIAEQLTLLDAELFYKIEIPEVLL---WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 917
E A Q+TL+D +F I+ PE L W+K++ +PN+ FT FN +S+WV I+
Sbjct: 53 EFASQITLMDIPVFKAIQ-PEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILT 111
Query: 918 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW------QKQTS 969
+ + R +L F+KI K L +LNN +S ++++SAL SAPI RL W K T
Sbjct: 112 AQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTF 171
Query: 970 EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
E L + D+ R Y +L V P IPYLG+ L DL ++ P N +
Sbjct: 172 EKLDYLMSKEDNYKRTREYIRSLKMV--PSIPYLGIYLLDLIYIDSAYPASGSIMENEQR 229
Query: 1030 RWQQFNILDSMRCFQ-QAHYD-------MRRNDDIINFFNDFSDHLAEEALWELSLKIKP 1081
Q NIL + Q YD +++ + + + E+ ++LSL+I+P
Sbjct: 230 SNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEEL-QKFVEDDNYKLSLRIEP 288
Query: 1082 RNITRRKTDREE 1093
+ + R +E
Sbjct: 289 GSSSPRLVSSKE 300
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 93.2 bits (230), Expect = 1e-18
Identities = 90/360 (25%), Positives = 160/360 (44%), Gaps = 23/360 (6%)
Query: 737 FLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEI 796
FL + +I +L KL + Y++ D K V + +L E+
Sbjct: 39 FLMMHPWYIPSSQLAAKLLHIYQQSRK--DNSNSLQVKTCHLVRYWISAFPAEFDLNPEL 96
Query: 797 LKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHD 856
+ + EL L G + ++ +D V K R T P+ + + L D
Sbjct: 97 AEQIKELKALLDQEGNRRHSSLID---IDSVPTYKWKRQVTQRNPVGQK--KRKMSLLFD 151
Query: 857 -FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSII 915
E+AE LT L+ F KI + + +P L +F FN++S WV+ +I
Sbjct: 152 HLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMI 211
Query: 916 MLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL-EWQKQTS----- 969
+ + A R ++ F+ + + L +L NFN+ +A++ L + I RL E S
Sbjct: 212 LSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIK 271
Query: 970 --EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYID---GK 1024
EGL E L+ ++ ++ YR L+ P LG+ L+DL + L PD++D +
Sbjct: 272 LWEGLTE---LVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTR 328
Query: 1025 VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFN-DFSDHLAEEALWELSLKIKPRN 1083
+N +K Q F+IL+ + ++ N D+++ + E+ L++LSL+ +PR+
Sbjct: 329 LNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS 388
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 93.2 bits (230), Expect = 1e-18
Identities = 90/360 (25%), Positives = 160/360 (44%), Gaps = 23/360 (6%)
Query: 737 FLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEI 796
FL + +I +L KL + Y++ D K V + +L E+
Sbjct: 39 FLMMHPWYIPSSQLAAKLLHIYQQSRK--DNSNSLQVKTCHLVRYWISAFPAEFDLNPEL 96
Query: 797 LKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHD 856
+ + EL L G + ++ +D V K R T P+ + + L D
Sbjct: 97 AEQIKELKALLDQEGNRRHSSLID---IDSVPTYKWKRQVTQRNPVGQK--KRKMSLLFD 151
Query: 857 -FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSII 915
E+AE LT L+ F KI + + +P L +F FN++S WV+ +I
Sbjct: 152 HLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMI 211
Query: 916 MLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL-EWQKQTS----- 969
+ + A R ++ F+ + + L +L NFN+ +A++ L + I RL E S
Sbjct: 212 LSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIK 271
Query: 970 --EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYID---GK 1024
EGL E L+ ++ ++ YR L+ P LG+ L+DL + L PD++D +
Sbjct: 272 LWEGLTE---LVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTR 328
Query: 1025 VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFN-DFSDHLAEEALWELSLKIKPRN 1083
+N +K Q F+IL+ + ++ N D+++ + E+ L++LSL+ +PR+
Sbjct: 329 LNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS 388
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 93.2 bits (230), Expect = 1e-18
Identities = 90/360 (25%), Positives = 160/360 (44%), Gaps = 23/360 (6%)
Query: 737 FLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEI 796
FL + +I +L KL + Y++ D K V + +L E+
Sbjct: 39 FLMMHPWYIPSSQLAAKLLHIYQQSRK--DNSNSLQVKTCHLVRYWISAFPAEFDLNPEL 96
Query: 797 LKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHD 856
+ + EL L G + ++ +D V K R T P+ + + L D
Sbjct: 97 AEQIKELKALLDQEGNRRHSSLID---IDSVPTYKWKRQVTQRNPVGQK--KRKMSLLFD 151
Query: 857 -FHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSII 915
E+AE LT L+ F KI + + +P L +F FN++S WV+ +I
Sbjct: 152 HLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMI 211
Query: 916 MLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL-EWQKQTS----- 969
+ + A R ++ F+ + + L +L NFN+ +A++ L + I RL E S
Sbjct: 212 LSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIK 271
Query: 970 --EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYID---GK 1024
EGL E L+ ++ ++ YR L+ P LG+ L+DL + L PD++D +
Sbjct: 272 LWEGLTE---LVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTR 328
Query: 1025 VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFN-DFSDHLAEEALWELSLKIKPRN 1083
+N +K Q F+IL+ + ++ N D+++ + E+ L++LSL+ +PR+
Sbjct: 329 LNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRS 388
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [Homo
sapiens]
Length = 456
Score = 92.8 bits (229), Expect = 2e-18
Identities = 55/183 (30%), Positives = 99/183 (54%), Gaps = 7/183 (3%)
Query: 854 LHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKSPNLTQFTEHFNNMSYWV 911
+H ++A LT ELF + E + ++ E+ ++ NL + + +++WV
Sbjct: 214 IHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWV 273
Query: 912 RSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTS 969
+ ++L E R +LL KFIKI ++ + S+ A++ LD+A + RL W+K
Sbjct: 274 ATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPG 333
Query: 970 EG---LAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVN 1026
+ ++ L D + ++YR +S+++PP IP++ LIL+DLTF+H G+ +DG VN
Sbjct: 334 KFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVN 393
Query: 1027 FSK 1029
K
Sbjct: 394 IEK 396
>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
[Homo sapiens]
Length = 473
Score = 91.7 bits (226), Expect = 3e-18
Identities = 71/253 (28%), Positives = 127/253 (50%), Gaps = 34/253 (13%)
Query: 862 IAEQLTLLDAELFYKIEIPEVL--LWAK---EQNEEKSPNLTQFTEHFNNMSYWVRSIIM 916
+AEQLTL+DAELF K+ + E L +W + + NE +P + HFN ++ + + +
Sbjct: 223 LAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCL 282
Query: 917 LQE--KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTSEGL 972
+A+DR R++ +IK+ + LNNF+S I+SAL S PI +L W +S+ +
Sbjct: 283 GDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSM 342
Query: 973 AEYCTLIDSSSSFR--------AYRAALSEVEPP------------CIPYLGLILQDLTF 1012
E L ++ + +++ A E P +P+LG L +L
Sbjct: 343 KELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQR 402
Query: 1013 VHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQA--HYDMRRNDDIINFFNDFSDHLAEE 1070
+ PD +DG N KR ++ +L M+ Q A +Y +R + + +F + L+++
Sbjct: 403 LDSAIPDDLDGNTN--KRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRM-EQLSDK 459
Query: 1071 ALWELSLKIKPRN 1083
++LS +++P N
Sbjct: 460 ESYKLSCQLEPEN 472
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 90.5 bits (223), Expect = 8e-18
Identities = 103/415 (24%), Positives = 179/415 (43%), Gaps = 74/415 (17%)
Query: 733 YCEAFLTTYRTFISPEELIKKLQYRY--------EKFSPFADTFKKRVSKNTFFVLVRVV 784
Y FL+TYR F S +E+++ L RY E+ + + K V +N ++R
Sbjct: 127 YISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDGSQSSSESKMVIRNAIASILRAW 186
Query: 785 DELCLVELTEE----ILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKL-------- 832
+ C + E L+ L++ + R++ + +N+L++ ++++
Sbjct: 187 LDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRA---QNLLEQFQKQEVETDNGLPN 243
Query: 833 -LRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWA--- 886
+ + + G +A F +AEQLT +DA+LF K+ L +W+
Sbjct: 244 TISFSLEEEEELEGGESAE---FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRD 300
Query: 887 KEQNEEKSPNLTQFTEHFNNMSYWVRSIIM--LQEKAQDRERLLLKFIKIMKHLRKLNNF 944
K++N+ +P + FN ++ V S I+ + K Q R +++ K+I I R L NF
Sbjct: 301 KKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNF 360
Query: 945 NSYLAILSALDSAPIRRLE--WQKQTSEGLAEYCTLID------------------SSSS 984
+S AI+SAL S I RL+ W + + + L D +S
Sbjct: 361 SSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSK 420
Query: 985 FRAYRAALSE----------------VEPPCIPYLGLILQDLTFVHLGNPDYID-GKVNF 1027
F +++ E V +PYLG L DLT + DYI+ G +NF
Sbjct: 421 FANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINF 480
Query: 1028 SKRWQQFNILDSMRCFQQA--HYDMRRNDDIINFFNDFSDHLAEEALWELSLKIK 1080
KR ++F ++ ++ Q A Y M + I +F L EE + LS +I+
Sbjct: 481 EKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQR-QQLLTEEESYALSCEIE 534
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 89.0 bits (219), Expect = 2e-17
Identities = 126/508 (24%), Positives = 199/508 (39%), Gaps = 73/508 (14%)
Query: 638 PPAG---KDGHPRDPSAVSGVPGKDSRDGSERAPKSPD-ALESAQSEEEVDELSLIDHNE 693
PP G RDP G G G E + + A S EEE + + +
Sbjct: 14 PPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGAVFTVTSRQ 73
Query: 694 I--MSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDL-VLYCEAFLTTYRTFISPEEL 750
+ L +R G+ + L+ H +T V + AFL T+R F S L
Sbjct: 74 YRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPAL 133
Query: 751 IKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVV---------DELCLVELTEEILKLLM 801
+ + R E +R ++ VL + + ++ E L
Sbjct: 134 LGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKGQLDRLESFLLQTG 193
Query: 802 ELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARG-VAARPGTLHDFHSH 860
+ V G L R LR +VD + +PLA G A P + F +
Sbjct: 194 YAAGKGVGGGSADLIRNLRS----RVDPQ----APDLPKPLALPGDPPADPTDVLVFLAD 245
Query: 861 EIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKS---PNLTQFTEHFNNMSYWVRSII 915
+AEQLTLLDAELF + + L LW S P++ FN ++ V S +
Sbjct: 246 HLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSV 305
Query: 916 MLQEKAQD--------------RERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 961
+ + R RLL K+I++ + R L NF+S A++SAL S+PI R
Sbjct: 306 LGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHR 365
Query: 962 LE--WQKQTSEGL---AEYCTLIDSSSSFRAYRAAL-------SEVEP------------ 997
L W + T + L + C + ++ R L S +EP
Sbjct: 366 LRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRG 425
Query: 998 -PCIPYLGLILQDLTFVHLGNPDYID-GKVNFSKRWQQFNILDSMRCFQQ--AHYDMRRN 1053
+PYLG L+DL + + D ++ G +NF KR ++F +L +R Q Y+++ +
Sbjct: 426 GGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPD 485
Query: 1054 DDIINFFNDFSDHLAEEALWELSLKIKP 1081
DI + L E +S +++P
Sbjct: 486 HDIQRWLQGLRP-LTEAQSHRVSCEVEP 512
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,945,088
Number of Sequences: 37866
Number of extensions: 2634741
Number of successful extensions: 14985
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 514
Number of HSP's that attempted gapping in prelim test: 11979
Number of HSP's gapped (non-prelim): 3150
length of query: 1095
length of database: 18,247,518
effective HSP length: 113
effective length of query: 982
effective length of database: 13,968,660
effective search space: 13717224120
effective search space used: 13717224120
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.