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Search of human proteins with 38348298
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38348298 ankyrin repeat domain 45 [Homo sapiens]
(266 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38348298 ankyrin repeat domain 45 [Homo sapiens] 531 e-151
gi|16507237 heat shock 70kDa protein 5 [Homo sapiens] 60 2e-09
gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Hom... 58 8e-09
gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo ... 58 8e-09
gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens] 57 2e-08
gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens] 56 3e-08
gi|241896857 hypothetical protein LOC100287718 [Homo sapiens] 54 1e-07
gi|239754321 PREDICTED: similar to ankyrin repeat domain 2 [Homo... 54 1e-07
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 54 2e-07
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 54 2e-07
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 54 2e-07
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 54 2e-07
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 54 2e-07
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 52 4e-07
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 51 9e-07
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 51 1e-06
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 50 3e-06
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ... 50 3e-06
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 50 3e-06
gi|17864094 feminization 1 homolog a [Homo sapiens] 50 3e-06
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 50 3e-06
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens] 49 3e-06
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun... 49 5e-06
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 49 5e-06
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 49 5e-06
gi|7657265 fem-1 homolog b [Homo sapiens] 49 5e-06
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 49 5e-06
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1... 49 6e-06
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 48 8e-06
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 48 8e-06
>gi|38348298 ankyrin repeat domain 45 [Homo sapiens]
Length = 266
Score = 531 bits (1367), Expect = e-151
Identities = 266/266 (100%), Positives = 266/266 (100%)
Query: 1 MESEGPPESESSEFFSQQEEENEEEEAQEPEETGPKNPLLQPALTGDVEGLQKIFEDPEN 60
MESEGPPESESSEFFSQQEEENEEEEAQEPEETGPKNPLLQPALTGDVEGLQKIFEDPEN
Sbjct: 1 MESEGPPESESSEFFSQQEEENEEEEAQEPEETGPKNPLLQPALTGDVEGLQKIFEDPEN 60
Query: 61 PHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAW 120
PHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAW
Sbjct: 61 PHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAW 120
Query: 121 GRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSL 180
GRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSL
Sbjct: 121 GRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSL 180
Query: 181 AVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQLEDIVTPIFTKM 240
AVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQLEDIVTPIFTKM
Sbjct: 181 AVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQLEDIVTPIFTKM 240
Query: 241 TTPCQVKSAKSVTSHDQKRSQDDTSN 266
TTPCQVKSAKSVTSHDQKRSQDDTSN
Sbjct: 241 TTPCQVKSAKSVTSHDQKRSQDDTSN 266
>gi|16507237 heat shock 70kDa protein 5 [Homo sapiens]
Length = 654
Score = 60.5 bits (145), Expect = 2e-09
Identities = 30/75 (40%), Positives = 44/75 (58%)
Query: 166 DARLTLKKYIAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQ 225
D R L+ Y + + D EK GKL EDK T+ A K EWLE+H +A I + +
Sbjct: 560 DTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAK 619
Query: 226 RQQLEDIVTPIFTKM 240
+++LE+IV PI +K+
Sbjct: 620 KKELEEIVQPIISKL 634
>gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Homo
sapiens]
Length = 1134
Score = 58.2 bits (139), Expect = 8e-09
Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 18/130 (13%)
Query: 39 LLQPALTGDVEGLQKIF---EDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRA 95
LL +L G+ + +Q+I +DP P+ E G L+ A AG +++++
Sbjct: 936 LLDSSLEGEFDLVQRIIYEVDDPSLPNDE------------GITALHNAVCAGHTEIVKF 983
Query: 96 LAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRE-ERARDVAARYS 154
L ++GVN+N + G+T LHCAA+ ++ K LVE + A+ + + + A D
Sbjct: 984 LVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEME 1043
Query: 155 Q--TECVEFL 162
+ T+C +FL
Sbjct: 1044 EGYTQCSQFL 1053
>gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo
sapiens]
Length = 1005
Score = 58.2 bits (139), Expect = 8e-09
Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 18/130 (13%)
Query: 39 LLQPALTGDVEGLQKIF---EDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRA 95
LL +L G+ + +Q+I +DP P+ E G L+ A AG +++++
Sbjct: 807 LLDSSLEGEFDLVQRIIYEVDDPSLPNDE------------GITALHNAVCAGHTEIVKF 854
Query: 96 LAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRE-ERARDVAARYS 154
L ++GVN+N + G+T LHCAA+ ++ K LVE + A+ + + + A D
Sbjct: 855 LVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEME 914
Query: 155 Q--TECVEFL 162
+ T+C +FL
Sbjct: 915 EGYTQCSQFL 924
>gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens]
Length = 614
Score = 57.0 bits (136), Expect = 2e-08
Identities = 51/208 (24%), Positives = 85/208 (40%), Gaps = 15/208 (7%)
Query: 63 HEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYG-VNLNEKTTRGYTLLHCAAAWG 121
H Q ++ +D G+ ++ A AG SD+I LA+ NL T LH AAA G
Sbjct: 217 HHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAG 276
Query: 122 RLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSLA 181
+ E +++L+EL +D + E A T CV+ L ++
Sbjct: 277 KAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQE----------SRTEPT 326
Query: 182 VTDTEKGSGKLLKEDKNTILSA--CRAKNEWLETHTEASINELF--EQRQQLEDIVTPIF 237
+ S KE + +L+ C+ K E H + + + E ++ DI+T
Sbjct: 327 RPPPSQSSRPQKKERRFNVLNQIFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFD 386
Query: 238 TKMTTPCQVKSAKSVTSHDQKRSQDDTS 265
+ + T CQ + V + K+ D S
Sbjct: 387 SIVGTNCQEQPGDQVAMVEFKKKTSDNS 414
Score = 32.0 bits (71), Expect = 0.58
Identities = 34/117 (29%), Positives = 46/117 (39%), Gaps = 18/117 (15%)
Query: 15 FSQQEEENEEEEAQEPEETGPKNPLLQPALTGDVEGLQKIF-EDPENPHHEQAMQLLLEE 73
F QQ ++ EE + Q A GDV L + EDP +L
Sbjct: 15 FDQQRGDSSEEV--------DLTMVYQAASNGDVNALTAVIREDPS---------ILECC 57
Query: 74 DIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALV 130
D G L A Q+D ++ L K G N+N + G T L A G LE +L+
Sbjct: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLL 114
>gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]
Length = 1090
Score = 56.2 bits (134), Expect = 3e-08
Identities = 54/210 (25%), Positives = 90/210 (42%), Gaps = 20/210 (9%)
Query: 6 PPESESSEFFSQQEEENEEEEAQEPEETGPKNPLLQPALTGDVEGLQKIF---EDPENPH 62
PP + +++ + ++ +E P LL +L G+ + +Q+I EDP P+
Sbjct: 859 PPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPN 918
Query: 63 HEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGR 122
E G L+ A AG +++ L +GVN+N + G+T LHCAA+
Sbjct: 919 DE------------GITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNS 966
Query: 123 LETLKALVELDVDIEALNFRE-ERARDVAARYSQ--TECVEFLDWADARLTLKKYIAKVS 179
+ K LVE I A + E A D + +C +FL +L + V+
Sbjct: 967 VHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMN--KGVA 1024
Query: 180 LAVTDTEKGSGKLLKEDKNTILSACRAKNE 209
A+ D E + L + L+ R K+E
Sbjct: 1025 YALWDYEAQNSDELSFHEGDALTILRRKDE 1054
>gi|241896857 hypothetical protein LOC100287718 [Homo sapiens]
Length = 222
Score = 54.3 bits (129), Expect = 1e-07
Identities = 34/89 (38%), Positives = 47/89 (52%)
Query: 78 RNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIE 137
R L+ A + GQ +VIR L +YG T+ G+T H AA G L LK L L I+
Sbjct: 71 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 130
Query: 138 ALNFREERARDVAARYSQTECVEFLDWAD 166
A +F + + +A Y Q CV FL+ A+
Sbjct: 131 APDFFGDTPKRIAQIYGQKACVAFLEKAE 159
>gi|239754321 PREDICTED: similar to ankyrin repeat domain 2 [Homo
sapiens]
Length = 245
Score = 54.3 bits (129), Expect = 1e-07
Identities = 34/89 (38%), Positives = 47/89 (52%)
Query: 78 RNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIE 137
R L+ A + GQ +VIR L +YG T+ G+T H AA G L LK L L I+
Sbjct: 94 RTPLHWAAIKGQMEVIRLLIEYGARPCLVTSVGWTPAHFAAEAGHLNILKTLHALHAAID 153
Query: 138 ALNFREERARDVAARYSQTECVEFLDWAD 166
A +F + + +A Y Q CV FL+ A+
Sbjct: 154 APDFFGDTPKRIAQIYGQKACVAFLEKAE 182
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 53.5 bits (127), Expect = 2e-07
Identities = 31/93 (33%), Positives = 51/93 (54%), Gaps = 6/93 (6%)
Query: 45 TGDVEGLQKIFEDPENPHHEQAMQLLLEEDIV------GRNLLYAACMAGQSDVIRALAK 98
T + GL + + H + ++LL +E I+ G L+ A +AGQ +V+R L
Sbjct: 73 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 132
Query: 99 YGVNLNEKTTRGYTLLHCAAAWGRLETLKALVE 131
YG N+N ++ +G+T L+ AA LE +K L+E
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
Score = 47.4 bits (111), Expect = 1e-05
Identities = 28/87 (32%), Positives = 44/87 (50%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G +++++ L + N N TT G+T LH AA G +ET+ AL+E + +
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
Query: 141 FREERARDVAARYSQTECVEFLDWADA 167
+ VAA+Y + E L DA
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDA 593
Score = 43.1 bits (100), Expect = 2e-04
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 7/117 (5%)
Query: 63 HEQAMQLLLEED-------IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H + ++LL++ + G L+ AC V+ L K G +++ T G T LH
Sbjct: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 442
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLK 172
A+ G L +K L++ N + E +AAR TE ++L A++ K
Sbjct: 443 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 499
Score = 41.2 bits (95), Expect = 0.001
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 48 VEGLQKIFEDPENPHHEQAMQLLLEE------DIVGRNLLYAACMAGQSDVIRALAKYGV 101
V+G+ + + H E LL ++ + G L+ G V L K+GV
Sbjct: 666 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725
Query: 102 NLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEF 161
++ T GYT LH A+ +G ++ +K L++ D+ A AA+ T+ V
Sbjct: 726 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 785
Query: 162 L 162
L
Sbjct: 786 L 786
Score = 39.7 bits (91), Expect = 0.003
Identities = 40/168 (23%), Positives = 64/168 (38%), Gaps = 7/168 (4%)
Query: 62 HHEQAMQLLLEE----DIV---GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLL 114
+H + M+LLL+ D V G L+ A G +++ L + G + N + T L
Sbjct: 415 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474
Query: 115 HCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKY 174
H AA G E K L++ + A ++ AAR T V+ L +A L
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534
Query: 175 IAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINEL 222
L + E +L + AC K + H A ++
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 582
Score = 37.4 bits (85), Expect = 0.014
Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 7/107 (6%)
Query: 63 HEQAMQLLLEEDI-------VGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLLE + G L+ A G + + AL + + T +G+T LH
Sbjct: 515 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 574
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
AA +G++ + L+E D A VA ++ + V+ L
Sbjct: 575 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
Score = 35.0 bits (79), Expect = 0.068
Identities = 19/54 (35%), Positives = 29/54 (53%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALV 130
G L+ A Q +V R+L +YG + N ++ +G T LH AA G E + L+
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
Score = 33.1 bits (74), Expect = 0.26
Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 68 QLLLEEDI----VGRN---LLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAW 120
+LLLE D G+N L+ A D+++ L G + + GYT LH AA
Sbjct: 586 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 645
Query: 121 GRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
++E ++L++ A + + +AA+ E V L
Sbjct: 646 NQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Score = 32.3 bits (72), Expect = 0.44
Identities = 18/71 (25%), Positives = 32/71 (45%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G + L +G + KT G + +H AA L+ ++ L++ D +I+ +
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 368
Query: 141 FREERARDVAA 151
VAA
Sbjct: 369 LDHLTPLHVAA 379
Score = 31.2 bits (69), Expect = 0.98
Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 7/84 (8%)
Query: 63 HEQAMQLLLE-----EDIVGRNL--LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLL+ +DI +L L+ A G V + L G N + G+T LH
Sbjct: 350 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409
Query: 116 CAAAWGRLETLKALVELDVDIEAL 139
A + ++ L++ I+A+
Sbjct: 410 IACKKNHVRVMELLLKTGASIDAV 433
Score = 28.9 bits (63), Expect = 4.9
Identities = 20/79 (25%), Positives = 34/79 (43%)
Query: 84 ACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRE 143
A +G D + GV++N G LH A+ G ++ + L+ ++ +E +
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 144 ERARDVAARYSQTECVEFL 162
A +AA Q E V L
Sbjct: 112 NTALHIAALAGQDEVVREL 130
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 53.5 bits (127), Expect = 2e-07
Identities = 31/93 (33%), Positives = 51/93 (54%), Gaps = 6/93 (6%)
Query: 45 TGDVEGLQKIFEDPENPHHEQAMQLLLEEDIV------GRNLLYAACMAGQSDVIRALAK 98
T + GL + + H + ++LL +E I+ G L+ A +AGQ +V+R L
Sbjct: 40 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 99
Query: 99 YGVNLNEKTTRGYTLLHCAAAWGRLETLKALVE 131
YG N+N ++ +G+T L+ AA LE +K L+E
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Score = 47.4 bits (111), Expect = 1e-05
Identities = 28/87 (32%), Positives = 44/87 (50%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G +++++ L + N N TT G+T LH AA G +ET+ AL+E + +
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 141 FREERARDVAARYSQTECVEFLDWADA 167
+ VAA+Y + E L DA
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA 560
Score = 43.1 bits (100), Expect = 2e-04
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 7/117 (5%)
Query: 63 HEQAMQLLLEED-------IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H + ++LL++ + G L+ AC V+ L K G +++ T G T LH
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLK 172
A+ G L +K L++ N + E +AAR TE ++L A++ K
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 41.2 bits (95), Expect = 0.001
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 48 VEGLQKIFEDPENPHHEQAMQLLLEE------DIVGRNLLYAACMAGQSDVIRALAKYGV 101
V+G+ + + H E LL ++ + G L+ G V L K+GV
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 102 NLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEF 161
++ T GYT LH A+ +G ++ +K L++ D+ A AA+ T+ V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 162 L 162
L
Sbjct: 753 L 753
Score = 39.7 bits (91), Expect = 0.003
Identities = 40/168 (23%), Positives = 64/168 (38%), Gaps = 7/168 (4%)
Query: 62 HHEQAMQLLLEE----DIV---GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLL 114
+H + M+LLL+ D V G L+ A G +++ L + G + N + T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 115 HCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKY 174
H AA G E K L++ + A ++ AAR T V+ L +A L
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 175 IAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINEL 222
L + E +L + AC K + H A ++
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Score = 37.4 bits (85), Expect = 0.014
Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 7/107 (6%)
Query: 63 HEQAMQLLLEEDI-------VGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLLE + G L+ A G + + AL + + T +G+T LH
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
AA +G++ + L+E D A VA ++ + V+ L
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 35.0 bits (79), Expect = 0.068
Identities = 19/54 (35%), Positives = 29/54 (53%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALV 130
G L+ A Q +V R+L +YG + N ++ +G T LH AA G E + L+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 33.1 bits (74), Expect = 0.26
Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 68 QLLLEEDI----VGRN---LLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAW 120
+LLLE D G+N L+ A D+++ L G + + GYT LH AA
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 612
Query: 121 GRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
++E ++L++ A + + +AA+ E V L
Sbjct: 613 NQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 32.3 bits (72), Expect = 0.44
Identities = 18/71 (25%), Positives = 32/71 (45%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G + L +G + KT G + +H AA L+ ++ L++ D +I+ +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 141 FREERARDVAA 151
VAA
Sbjct: 336 LDHLTPLHVAA 346
Score = 31.2 bits (69), Expect = 0.98
Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 7/84 (8%)
Query: 63 HEQAMQLLLE-----EDIVGRNL--LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLL+ +DI +L L+ A G V + L G N + G+T LH
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 116 CAAAWGRLETLKALVELDVDIEAL 139
A + ++ L++ I+A+
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAV 400
Score = 28.9 bits (63), Expect = 4.9
Identities = 20/79 (25%), Positives = 34/79 (43%)
Query: 84 ACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRE 143
A +G D + GV++N G LH A+ G ++ + L+ ++ +E +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 144 ERARDVAARYSQTECVEFL 162
A +AA Q E V L
Sbjct: 79 NTALHIAALAGQDEVVREL 97
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 53.5 bits (127), Expect = 2e-07
Identities = 31/93 (33%), Positives = 51/93 (54%), Gaps = 6/93 (6%)
Query: 45 TGDVEGLQKIFEDPENPHHEQAMQLLLEEDIV------GRNLLYAACMAGQSDVIRALAK 98
T + GL + + H + ++LL +E I+ G L+ A +AGQ +V+R L
Sbjct: 40 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 99
Query: 99 YGVNLNEKTTRGYTLLHCAAAWGRLETLKALVE 131
YG N+N ++ +G+T L+ AA LE +K L+E
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Score = 47.4 bits (111), Expect = 1e-05
Identities = 28/87 (32%), Positives = 44/87 (50%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G +++++ L + N N TT G+T LH AA G +ET+ AL+E + +
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 141 FREERARDVAARYSQTECVEFLDWADA 167
+ VAA+Y + E L DA
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA 560
Score = 43.1 bits (100), Expect = 2e-04
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 7/117 (5%)
Query: 63 HEQAMQLLLEED-------IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H + ++LL++ + G L+ AC V+ L K G +++ T G T LH
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLK 172
A+ G L +K L++ N + E +AAR TE ++L A++ K
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 41.2 bits (95), Expect = 0.001
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 48 VEGLQKIFEDPENPHHEQAMQLLLEE------DIVGRNLLYAACMAGQSDVIRALAKYGV 101
V+G+ + + H E LL ++ + G L+ G V L K+GV
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 102 NLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEF 161
++ T GYT LH A+ +G ++ +K L++ D+ A AA+ T+ V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 162 L 162
L
Sbjct: 753 L 753
Score = 39.7 bits (91), Expect = 0.003
Identities = 40/168 (23%), Positives = 64/168 (38%), Gaps = 7/168 (4%)
Query: 62 HHEQAMQLLLEE----DIV---GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLL 114
+H + M+LLL+ D V G L+ A G +++ L + G + N + T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 115 HCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKY 174
H AA G E K L++ + A ++ AAR T V+ L +A L
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 175 IAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINEL 222
L + E +L + AC K + H A ++
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Score = 37.4 bits (85), Expect = 0.014
Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 7/107 (6%)
Query: 63 HEQAMQLLLEEDI-------VGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLLE + G L+ A G + + AL + + T +G+T LH
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
AA +G++ + L+E D A VA ++ + V+ L
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 35.0 bits (79), Expect = 0.068
Identities = 19/54 (35%), Positives = 29/54 (53%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALV 130
G L+ A Q +V R+L +YG + N ++ +G T LH AA G E + L+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 33.1 bits (74), Expect = 0.26
Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 68 QLLLEEDI----VGRN---LLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAW 120
+LLLE D G+N L+ A D+++ L G + + GYT LH AA
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 612
Query: 121 GRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
++E ++L++ A + + +AA+ E V L
Sbjct: 613 NQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 32.3 bits (72), Expect = 0.44
Identities = 18/71 (25%), Positives = 32/71 (45%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G + L +G + KT G + +H AA L+ ++ L++ D +I+ +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 141 FREERARDVAA 151
VAA
Sbjct: 336 LDHLTPLHVAA 346
Score = 31.2 bits (69), Expect = 0.98
Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 7/84 (8%)
Query: 63 HEQAMQLLLE-----EDIVGRNL--LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLL+ +DI +L L+ A G V + L G N + G+T LH
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 116 CAAAWGRLETLKALVELDVDIEAL 139
A + ++ L++ I+A+
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAV 400
Score = 28.9 bits (63), Expect = 4.9
Identities = 20/79 (25%), Positives = 34/79 (43%)
Query: 84 ACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRE 143
A +G D + GV++N G LH A+ G ++ + L+ ++ +E +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 144 ERARDVAARYSQTECVEFL 162
A +AA Q E V L
Sbjct: 79 NTALHIAALAGQDEVVREL 97
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 53.5 bits (127), Expect = 2e-07
Identities = 31/93 (33%), Positives = 51/93 (54%), Gaps = 6/93 (6%)
Query: 45 TGDVEGLQKIFEDPENPHHEQAMQLLLEEDIV------GRNLLYAACMAGQSDVIRALAK 98
T + GL + + H + ++LL +E I+ G L+ A +AGQ +V+R L
Sbjct: 40 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 99
Query: 99 YGVNLNEKTTRGYTLLHCAAAWGRLETLKALVE 131
YG N+N ++ +G+T L+ AA LE +K L+E
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Score = 47.4 bits (111), Expect = 1e-05
Identities = 28/87 (32%), Positives = 44/87 (50%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G +++++ L + N N TT G+T LH AA G +ET+ AL+E + +
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 141 FREERARDVAARYSQTECVEFLDWADA 167
+ VAA+Y + E L DA
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA 560
Score = 43.1 bits (100), Expect = 2e-04
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 7/117 (5%)
Query: 63 HEQAMQLLLEED-------IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H + ++LL++ + G L+ AC V+ L K G +++ T G T LH
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLK 172
A+ G L +K L++ N + E +AAR TE ++L A++ K
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 41.2 bits (95), Expect = 0.001
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 48 VEGLQKIFEDPENPHHEQAMQLLLEE------DIVGRNLLYAACMAGQSDVIRALAKYGV 101
V+G+ + + H E LL ++ + G L+ G V L K+GV
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 102 NLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEF 161
++ T GYT LH A+ +G ++ +K L++ D+ A AA+ T+ V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 162 L 162
L
Sbjct: 753 L 753
Score = 39.7 bits (91), Expect = 0.003
Identities = 40/168 (23%), Positives = 64/168 (38%), Gaps = 7/168 (4%)
Query: 62 HHEQAMQLLLEE----DIV---GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLL 114
+H + M+LLL+ D V G L+ A G +++ L + G + N + T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 115 HCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKY 174
H AA G E K L++ + A ++ AAR T V+ L +A L
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 175 IAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINEL 222
L + E +L + AC K + H A ++
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Score = 37.4 bits (85), Expect = 0.014
Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 7/107 (6%)
Query: 63 HEQAMQLLLEEDI-------VGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLLE + G L+ A G + + AL + + T +G+T LH
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
AA +G++ + L+E D A VA ++ + V+ L
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 35.0 bits (79), Expect = 0.068
Identities = 19/54 (35%), Positives = 29/54 (53%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALV 130
G L+ A Q +V R+L +YG + N ++ +G T LH AA G E + L+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 33.1 bits (74), Expect = 0.26
Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 68 QLLLEEDI----VGRN---LLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAW 120
+LLLE D G+N L+ A D+++ L G + + GYT LH AA
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 612
Query: 121 GRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
++E ++L++ A + + +AA+ E V L
Sbjct: 613 NQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 32.3 bits (72), Expect = 0.44
Identities = 18/71 (25%), Positives = 32/71 (45%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G + L +G + KT G + +H AA L+ ++ L++ D +I+ +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 141 FREERARDVAA 151
VAA
Sbjct: 336 LDHLTPLHVAA 346
Score = 31.2 bits (69), Expect = 0.98
Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 7/84 (8%)
Query: 63 HEQAMQLLLE-----EDIVGRNL--LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLL+ +DI +L L+ A G V + L G N + G+T LH
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 116 CAAAWGRLETLKALVELDVDIEAL 139
A + ++ L++ I+A+
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAV 400
Score = 28.9 bits (63), Expect = 4.9
Identities = 20/79 (25%), Positives = 34/79 (43%)
Query: 84 ACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRE 143
A +G D + GV++N G LH A+ G ++ + L+ ++ +E +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 144 ERARDVAARYSQTECVEFL 162
A +AA Q E V L
Sbjct: 79 NTALHIAALAGQDEVVREL 97
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 53.5 bits (127), Expect = 2e-07
Identities = 31/93 (33%), Positives = 51/93 (54%), Gaps = 6/93 (6%)
Query: 45 TGDVEGLQKIFEDPENPHHEQAMQLLLEEDIV------GRNLLYAACMAGQSDVIRALAK 98
T + GL + + H + ++LL +E I+ G L+ A +AGQ +V+R L
Sbjct: 40 TCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN 99
Query: 99 YGVNLNEKTTRGYTLLHCAAAWGRLETLKALVE 131
YG N+N ++ +G+T L+ AA LE +K L+E
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Score = 47.4 bits (111), Expect = 1e-05
Identities = 28/87 (32%), Positives = 44/87 (50%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G +++++ L + N N TT G+T LH AA G +ET+ AL+E + +
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 141 FREERARDVAARYSQTECVEFLDWADA 167
+ VAA+Y + E L DA
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA 560
Score = 43.1 bits (100), Expect = 2e-04
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 7/117 (5%)
Query: 63 HEQAMQLLLEED-------IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H + ++LL++ + G L+ AC V+ L K G +++ T G T LH
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLK 172
A+ G L +K L++ N + E +AAR TE ++L A++ K
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 41.2 bits (95), Expect = 0.001
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 6/121 (4%)
Query: 48 VEGLQKIFEDPENPHHEQAMQLLLEE------DIVGRNLLYAACMAGQSDVIRALAKYGV 101
V+G+ + + H E LL ++ + G L+ G V L K+GV
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 102 NLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEF 161
++ T GYT LH A+ +G ++ +K L++ D+ A AA+ T+ V
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 162 L 162
L
Sbjct: 753 L 753
Score = 39.7 bits (91), Expect = 0.003
Identities = 40/168 (23%), Positives = 64/168 (38%), Gaps = 7/168 (4%)
Query: 62 HHEQAMQLLLEE----DIV---GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLL 114
+H + M+LLL+ D V G L+ A G +++ L + G + N + T L
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Query: 115 HCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKY 174
H AA G E K L++ + A ++ AAR T V+ L +A L
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 175 IAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASINEL 222
L + E +L + AC K + H A ++
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKV 549
Score = 37.4 bits (85), Expect = 0.014
Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 7/107 (6%)
Query: 63 HEQAMQLLLEEDI-------VGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLLE + G L+ A G + + AL + + T +G+T LH
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
AA +G++ + L+E D A VA ++ + V+ L
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Score = 35.0 bits (79), Expect = 0.068
Identities = 19/54 (35%), Positives = 29/54 (53%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALV 130
G L+ A Q +V R+L +YG + N ++ +G T LH AA G E + L+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 33.1 bits (74), Expect = 0.26
Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 68 QLLLEEDI----VGRN---LLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAW 120
+LLLE D G+N L+ A D+++ L G + + GYT LH AA
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 612
Query: 121 GRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
++E ++L++ A + + +AA+ E V L
Sbjct: 613 NQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 32.3 bits (72), Expect = 0.44
Identities = 18/71 (25%), Positives = 32/71 (45%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G + L +G + KT G + +H AA L+ ++ L++ D +I+ +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 141 FREERARDVAA 151
VAA
Sbjct: 336 LDHLTPLHVAA 346
Score = 31.2 bits (69), Expect = 0.98
Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 7/84 (8%)
Query: 63 HEQAMQLLLE-----EDIVGRNL--LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H ++LLL+ +DI +L L+ A G V + L G N + G+T LH
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376
Query: 116 CAAAWGRLETLKALVELDVDIEAL 139
A + ++ L++ I+A+
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAV 400
Score = 28.9 bits (63), Expect = 4.9
Identities = 20/79 (25%), Positives = 34/79 (43%)
Query: 84 ACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFRE 143
A +G D + GV++N G LH A+ G ++ + L+ ++ +E +
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 144 ERARDVAARYSQTECVEFL 162
A +AA Q E V L
Sbjct: 79 NTALHIAALAGQDEVVREL 97
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 52.4 bits (124), Expect = 4e-07
Identities = 40/134 (29%), Positives = 58/134 (43%), Gaps = 7/134 (5%)
Query: 38 PLLQPALTGDVEGLQKIFEDPENPHHEQAMQLLLEE------DIVGRNLLYAACMAGQSD 91
PLL D G + N H E LL + D R L+ A G D
Sbjct: 103 PLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLD 162
Query: 92 VIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAA 151
V+ L +G + K +GYT LH AA+ G++ +K L+ L V+I+ +N A +A
Sbjct: 163 VVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIAC 222
Query: 152 RYSQTECV-EFLDW 164
Q V E +D+
Sbjct: 223 YNGQDAVVNELIDY 236
Score = 43.9 bits (102), Expect = 1e-04
Identities = 20/48 (41%), Positives = 27/48 (56%)
Query: 72 EEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAA 119
E ++ G L+ AC GQ V+ L YG N+N+ G+T LH AAA
Sbjct: 209 EINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAA 256
Score = 42.7 bits (99), Expect = 3e-04
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 10/110 (9%)
Query: 63 HEQAMQLLLEE-------DIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H A+ LLLE+ DI+G L+ M G + ++ L + V++ K +RG T LH
Sbjct: 657 HIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLH 716
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVA--ARYSQTE-CVEFL 162
AAA G L L+++ + E F++ + A Y+ E C+E L
Sbjct: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Score = 37.7 bits (86), Expect = 0.010
Identities = 23/85 (27%), Positives = 37/85 (43%)
Query: 78 RNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIE 137
R L+ A G +++I L G +N K T LH A A E ++ L++ D+
Sbjct: 17 RTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVN 76
Query: 138 ALNFREERARDVAARYSQTECVEFL 162
A + + VAA +C E +
Sbjct: 77 ARDKNWQTPLHVAAANKAVKCAEVI 101
Score = 37.7 bits (86), Expect = 0.010
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 2/106 (1%)
Query: 74 DIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTL--LHCAAAWGRLETLKALVE 131
D G N ++ A G + L + + E++ G T LH AA G + L+ L++
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563
Query: 132 LDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAK 177
VD++ + + A D+AA TECVE L A + +K + K
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609
Score = 35.4 bits (80), Expect = 0.052
Identities = 24/82 (29%), Positives = 32/82 (39%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A + SD R L G ++ G T LH AAA G +E +K L D +
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 141 FREERARDVAARYSQTECVEFL 162
AA C+E L
Sbjct: 411 KCGRTPLHYAAANCHFHCIETL 432
Score = 34.7 bits (78), Expect = 0.089
Identities = 32/101 (31%), Positives = 44/101 (43%), Gaps = 5/101 (4%)
Query: 72 EEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVE 131
++D GR L+ A I L G N+NE G T LH AAA L
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
Query: 132 LDVDIEALNFREERARDVAARYSQTECVEFLDWADARLTLK 172
+ E L ERAR++ + T C+EFL DA +++
Sbjct: 468 AHDNSEEL----ERARELKEK-EATLCLEFLLQNDANPSIR 503
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 51.2 bits (121), Expect = 9e-07
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 63 HEQAMQLLLEEDIV-------GRNLLYAACMAGQSDVIRALAKYG---VNLNEKTTRGYT 112
H+ +++LL D + G L+ A G + ++R L G +NE+ T
Sbjct: 92 HKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNET 151
Query: 113 LLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
LHCAA +G E +K L+E D N + E D+AA Y + E V+ L
Sbjct: 152 ALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKML 201
Score = 36.6 bits (83), Expect = 0.023
Identities = 29/125 (23%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 38 PLLQPALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALA 97
PL A GD + ++ + + P H + E++ L+ A G ++V++ L
Sbjct: 116 PLHLAAWKGDAQIVRLLIH--QGPSHTRVN----EQNNDNETALHCAAQYGHTEVVKVLL 169
Query: 98 KYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTE 157
+ + + + T L AA +GRLE +K L+ ++ + N ++ +AAR
Sbjct: 170 EELTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKA 229
Query: 158 CVEFL 162
V+ L
Sbjct: 230 VVQVL 234
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 50.8 bits (120), Expect = 1e-06
Identities = 39/120 (32%), Positives = 53/120 (44%), Gaps = 7/120 (5%)
Query: 43 ALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVN 102
A G V L I ED E+ + D +GR + A GQ D + L G +
Sbjct: 132 AQKGHVPVLAFIMEDLEDVALDHV-------DKLGRTAFHRAAEHGQLDALDFLVGSGCD 184
Query: 103 LNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
N K G T LH AA G + L+ LV++ +D+E N A AA S +CV+ L
Sbjct: 185 HNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLL 244
Score = 47.0 bits (110), Expect = 2e-05
Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 21/120 (17%)
Query: 63 HEQAMQLLLE-------EDIVGR----------NLLYAACMAGQSDVIRALAKYGVNLNE 105
HEQA++LLLE ED VG N L + G +++ L G ++
Sbjct: 60 HEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHC 119
Query: 106 KTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDV---AARYSQTECVEFL 162
++ G TLLHCAA G + L ++E D++ AL+ ++ R AA + Q + ++FL
Sbjct: 120 ESKDGLTLLHCAAQKGHVPVLAFIME-DLEDVALDHVDKLGRTAFHRAAEHGQLDALDFL 178
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 49.7 bits (117), Expect = 3e-06
Identities = 26/72 (36%), Positives = 41/72 (56%)
Query: 69 LLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKA 128
L D R L+ AC AG ++++ L + GV +N+K G++ LH AA+ GR E +KA
Sbjct: 32 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
Query: 129 LVELDVDIEALN 140
L+ + A+N
Sbjct: 92 LLGKGAQVNAVN 103
Score = 31.6 bits (70), Expect = 0.75
Identities = 28/94 (29%), Positives = 37/94 (39%), Gaps = 6/94 (6%)
Query: 63 HEQAMQLLL------EEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHC 116
HE A+ LL +D ++ A G +I L Y + N + T G T LH
Sbjct: 119 HEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178
Query: 117 AAAWGRLETLKALVELDVDIEALNFREERARDVA 150
A R+E K LV I N E+ VA
Sbjct: 179 ACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
sapiens]
Length = 151
Score = 49.7 bits (117), Expect = 3e-06
Identities = 26/72 (36%), Positives = 41/72 (56%)
Query: 69 LLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKA 128
L D R L+ AC AG ++++ L + GV +N+K G++ LH AA+ GR E +KA
Sbjct: 32 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
Query: 129 LVELDVDIEALN 140
L+ + A+N
Sbjct: 92 LLGKGAQVNAVN 103
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 49.7 bits (117), Expect = 3e-06
Identities = 32/92 (34%), Positives = 44/92 (47%)
Query: 75 IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDV 134
++ + L+ A G + R L G T+ GYT LH AA G L T+K LVE
Sbjct: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKA 694
Query: 135 DIEALNFREERARDVAARYSQTECVEFLDWAD 166
D+ A + A +AA + +E VE L AD
Sbjct: 695 DVLARGPLNQTALHLAAAHGHSEVVEELVSAD 726
Score = 46.2 bits (108), Expect = 3e-05
Identities = 43/162 (26%), Positives = 70/162 (43%), Gaps = 17/162 (10%)
Query: 81 LYAACMAGQSDVIRALAKY-GVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEAL 139
L+ A G +++ LAK GV++N +T G T LH AA G + L++L D+
Sbjct: 574 LHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVC 633
Query: 140 NFREERARDVAARYSQTECVEFLDWADA---RLTLKKYIAKVSLAVTDTEKGSGKLLKED 196
+ + VAA T L A +T Y A + LA + + KLL E+
Sbjct: 634 SLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTA-LHLAARNGHLATVKLLVEE 692
Query: 197 KNTI------------LSACRAKNEWLETHTEASINELFEQR 226
K + L+A +E +E A + +LF+++
Sbjct: 693 KADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQ 734
Score = 33.5 bits (75), Expect = 0.20
Identities = 36/138 (26%), Positives = 56/138 (40%), Gaps = 18/138 (13%)
Query: 36 KNPLLQPALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRA 95
K L+ ++GD L KI + Q + L L+ G +LL+ A AGQ + +
Sbjct: 407 KKKLVDAIVSGDTSKLMKILQP-------QDVDLALDS---GASLLHLAVEAGQEECAKW 456
Query: 96 LAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQ 155
L N N RG T LH A ++ L+ + + A + + A AA+
Sbjct: 457 LLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNG- 515
Query: 156 TECVEFLDWADARLTLKK 173
D + RL L+K
Sbjct: 516 -------DESSTRLLLEK 526
Score = 30.8 bits (68), Expect = 1.3
Identities = 25/86 (29%), Positives = 34/86 (39%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
GR L+ A G V R L ++N + T LH AA G T + L+
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGK 663
Query: 137 EALNFREERARDVAARYSQTECVEFL 162
EA+ A +AAR V+ L
Sbjct: 664 EAMTSDGYTALHLAARNGHLATVKLL 689
Score = 30.8 bits (68), Expect = 1.3
Identities = 26/96 (27%), Positives = 43/96 (44%), Gaps = 1/96 (1%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A G ++ L + ++ + T LH AAA G E ++ LV DV I
Sbjct: 670 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-I 728
Query: 137 EALNFREERARDVAARYSQTECVEFLDWADARLTLK 172
+ + + A +AA+ + VE L A + L+
Sbjct: 729 DLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQ 764
>gi|17864094 feminization 1 homolog a [Homo sapiens]
Length = 617
Score = 49.7 bits (117), Expect = 3e-06
Identities = 47/176 (26%), Positives = 73/176 (41%), Gaps = 3/176 (1%)
Query: 20 EENEEEEAQEPEETGPKNPLLQPALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGRN 79
+ EE + E+T PLL A G ++ ++ + E E I G
Sbjct: 26 KSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAP 85
Query: 80 LLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEAL 139
L+AA AG V+++L +G ++N T T L A G LE +K LVE D+E
Sbjct: 86 PLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVS 145
Query: 140 NFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSLAVTD-TEKGSGKLLK 194
N ++ E ++L A + K K + A+ D E GS ++K
Sbjct: 146 NRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKS--VKGNTALHDCAESGSLDIMK 199
Score = 37.7 bits (86), Expect = 0.010
Identities = 17/54 (31%), Positives = 29/54 (53%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALV 130
G L +C G ++ + L + G ++N K+ +G T LH A G L+ +K L+
Sbjct: 149 GHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
Score = 31.2 bits (69), Expect = 0.98
Identities = 18/82 (21%), Positives = 35/82 (42%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L AAC G ++++ L ++ +L G+T L + G E + L+E D+ +
Sbjct: 120 LRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKS 179
Query: 141 FREERARDVAARYSQTECVEFL 162
+ A A + ++ L
Sbjct: 180 VKGNTALHDCAESGSLDIMKML 201
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 49.7 bits (117), Expect = 3e-06
Identities = 41/140 (29%), Positives = 68/140 (48%), Gaps = 9/140 (6%)
Query: 1 MESEGPPESESS-EFFSQQEEENEEEEAQEPEETGPKNPLLQPALT-----GDVEGLQ-K 53
++ + PE+E+ S E+E+EEEEA+E T L + D +GL +
Sbjct: 444 LQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGEDDTDGLTPQ 503
Query: 54 IFEDPENPHH--EQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGY 111
+ ED E H + + +G LL+ AC+ GQ ++ L + G LN + G+
Sbjct: 504 LEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGW 563
Query: 112 TLLHCAAAWGRLETLKALVE 131
T LH A +G LE ++ L++
Sbjct: 564 TPLHEACNYGHLEIVRFLLD 583
Score = 31.2 bits (69), Expect = 0.98
Identities = 35/137 (25%), Positives = 57/137 (41%), Gaps = 16/137 (11%)
Query: 3 SEGPPESESSEFFSQQEEENEEEEAQEPEETGPK----NPLLQPAL-TGDVEGLQKIFED 57
SEG +++ + Q EE+EE + G K N + + L +EG + +D
Sbjct: 491 SEGEDDTDG---LTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQD 547
Query: 58 PENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNE---KTTRGYTLL 114
H L D G L+ AC G +++R L +G +++ + G T L
Sbjct: 548 LVRQGHP-----LNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPL 602
Query: 115 HCAAAWGRLETLKALVE 131
H A G E + L+E
Sbjct: 603 HDALNCGHFEVAELLLE 619
>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
Length = 1858
Score = 49.3 bits (116), Expect = 3e-06
Identities = 26/80 (32%), Positives = 46/80 (57%)
Query: 72 EEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVE 131
E++ G LL+ AC +G +V+ + ++G +LN + +T LH AA +G+ +K L+
Sbjct: 217 EKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLM 276
Query: 132 LDVDIEALNFREERARDVAA 151
+ +N EE+A D+AA
Sbjct: 277 HQANPHLVNCNEEKASDIAA 296
Score = 44.7 bits (104), Expect = 9e-05
Identities = 41/153 (26%), Positives = 64/153 (41%), Gaps = 13/153 (8%)
Query: 100 GVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECV 159
G N+NEK G TLLH A A G E + ++E D+ ++ + +AA+Y QT V
Sbjct: 212 GGNVNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLV 271
Query: 160 EFLDWADARLTLKKYIAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLETHTEASI 219
+ L + A L + EK S E +L +A+ W E E
Sbjct: 272 KL---------LLMHQANPHLVNCNEEKASDIAASEFIEEML--LKAEIAWEEKMKEPLS 320
Query: 220 NELFEQRQQLEDIV--TPIFTKMTTPCQVKSAK 250
Q + E+I+ P+ + +P + AK
Sbjct: 321 ASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAK 353
>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform b [Homo sapiens]
Length = 943
Score = 48.9 bits (115), Expect = 5e-06
Identities = 27/74 (36%), Positives = 42/74 (56%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A G ++V++ L + G ++N K G+T LH AA WG+ E + LV+ D+
Sbjct: 112 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 171
Query: 137 EALNFREERARDVA 150
E +N + A DVA
Sbjct: 172 EMVNKVGQTAFDVA 185
Score = 35.8 bits (81), Expect = 0.040
Identities = 17/69 (24%), Positives = 35/69 (50%)
Query: 92 VIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAA 151
+++ L + G N+N+ G+ LH AA+ G L+ + L+ + A+N + D+A
Sbjct: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
Query: 152 RYSQTECVE 160
+ E ++
Sbjct: 61 EEAMEELLQ 69
Score = 34.3 bits (77), Expect = 0.12
Identities = 43/217 (19%), Positives = 91/217 (41%), Gaps = 8/217 (3%)
Query: 56 EDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVN---LNE--KTTRG 110
+ P + E+AM+ LL+ ++ + + A + ++ A+ +N +N+ G
Sbjct: 53 DTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSG 112
Query: 111 YTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLT 170
T LH AAA G E LK L++ D+ ++ AA + + E L +
Sbjct: 113 GTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDME 172
Query: 171 LKKYIAKVSLAVTDTE-KGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQL 229
+ + + + V D + G + L++ +N + S R K L T N + ++
Sbjct: 173 MVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNN--QSQKTF 230
Query: 230 EDIVTPIFTKMTTPCQVKSAKSVTSHDQKRSQDDTSN 266
++ T I +++S + +++ + D S+
Sbjct: 231 KNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESS 267
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 48.9 bits (115), Expect = 5e-06
Identities = 27/74 (36%), Positives = 42/74 (56%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A G ++V++ L + G ++N K G+T LH AA WG+ E + LV+ D+
Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 258
Query: 137 EALNFREERARDVA 150
E +N + A DVA
Sbjct: 259 EMVNKVGQTAFDVA 272
Score = 45.1 bits (105), Expect = 7e-05
Identities = 22/87 (25%), Positives = 44/87 (50%)
Query: 74 DIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELD 133
++ G L+ AC+ D+++ L + G N+N+ G+ LH AA+ G L+ + L+
Sbjct: 70 NVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQG 129
Query: 134 VDIEALNFREERARDVAARYSQTECVE 160
+ A+N + D+A + E ++
Sbjct: 130 AHVGAVNSEGDTPLDIAEEEAMEELLQ 156
Score = 34.3 bits (77), Expect = 0.12
Identities = 43/217 (19%), Positives = 91/217 (41%), Gaps = 8/217 (3%)
Query: 56 EDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVN---LNE--KTTRG 110
+ P + E+AM+ LL+ ++ + + A + ++ A+ +N +N+ G
Sbjct: 140 DTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSG 199
Query: 111 YTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLT 170
T LH AAA G E LK L++ D+ ++ AA + + E L +
Sbjct: 200 GTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDME 259
Query: 171 LKKYIAKVSLAVTDTE-KGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQL 229
+ + + + V D + G + L++ +N + S R K L T N + ++
Sbjct: 260 MVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNN--QSQKTF 317
Query: 230 EDIVTPIFTKMTTPCQVKSAKSVTSHDQKRSQDDTSN 266
++ T I +++S + +++ + D S+
Sbjct: 318 KNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESS 354
Score = 33.5 bits (75), Expect = 0.20
Identities = 23/80 (28%), Positives = 34/80 (42%)
Query: 83 AACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFR 142
AAC +G +D + L G ++N G T LH A ++ +K LVE +I +
Sbjct: 46 AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE 105
Query: 143 EERARDVAARYSQTECVEFL 162
AA + EFL
Sbjct: 106 GWIPLHAAASCGYLDIAEFL 125
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 48.9 bits (115), Expect = 5e-06
Identities = 27/74 (36%), Positives = 42/74 (56%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A G ++V++ L + G ++N K G+T LH AA WG+ E + LV+ D+
Sbjct: 199 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 258
Query: 137 EALNFREERARDVA 150
E +N + A DVA
Sbjct: 259 EMVNKVGQTAFDVA 272
Score = 45.1 bits (105), Expect = 7e-05
Identities = 22/87 (25%), Positives = 44/87 (50%)
Query: 74 DIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELD 133
++ G L+ AC+ D+++ L + G N+N+ G+ LH AA+ G L+ + L+
Sbjct: 70 NVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQG 129
Query: 134 VDIEALNFREERARDVAARYSQTECVE 160
+ A+N + D+A + E ++
Sbjct: 130 AHVGAVNSEGDTPLDIAEEEAMEELLQ 156
Score = 34.3 bits (77), Expect = 0.12
Identities = 43/217 (19%), Positives = 91/217 (41%), Gaps = 8/217 (3%)
Query: 56 EDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVN---LNE--KTTRG 110
+ P + E+AM+ LL+ ++ + + A + ++ A+ +N +N+ G
Sbjct: 140 DTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSG 199
Query: 111 YTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFLDWADARLT 170
T LH AAA G E LK L++ D+ ++ AA + + E L +
Sbjct: 200 GTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDME 259
Query: 171 LKKYIAKVSLAVTDTE-KGSGKLLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQL 229
+ + + + V D + G + L++ +N + S R K L T N + ++
Sbjct: 260 MVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNN--QSQKTF 317
Query: 230 EDIVTPIFTKMTTPCQVKSAKSVTSHDQKRSQDDTSN 266
++ T I +++S + +++ + D S+
Sbjct: 318 KNKETLIIEPEKNASRIESLEQEKVDEEEEGKKDESS 354
Score = 33.5 bits (75), Expect = 0.20
Identities = 23/80 (28%), Positives = 34/80 (42%)
Query: 83 AACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFR 142
AAC +G +D + L G ++N G T LH A ++ +K LVE +I +
Sbjct: 46 AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE 105
Query: 143 EERARDVAARYSQTECVEFL 162
AA + EFL
Sbjct: 106 GWIPLHAAASCGYLDIAEFL 125
>gi|7657265 fem-1 homolog b [Homo sapiens]
Length = 627
Score = 48.9 bits (115), Expect = 5e-06
Identities = 29/88 (32%), Positives = 43/88 (48%)
Query: 75 IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDV 134
I G L+ A AG +V++ L +G N+N T T L A GRL+ +K LVE +
Sbjct: 86 IDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNA 145
Query: 135 DIEALNFREERARDVAARYSQTECVEFL 162
+I N + +AA T+ V +L
Sbjct: 146 NISIANKYDNTCLMIAAYKGHTDVVRYL 173
Score = 35.4 bits (80), Expect = 0.052
Identities = 26/82 (31%), Positives = 38/82 (46%), Gaps = 1/82 (1%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L A G +DV+R L + + N K G T LH AA G ++ +K L++ I +N
Sbjct: 158 LMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAI-VVN 216
Query: 141 FREERARDVAARYSQTECVEFL 162
VAA + + VE L
Sbjct: 217 GHGMTPLKVAAESCKADVVELL 238
Score = 31.2 bits (69), Expect = 0.98
Identities = 24/88 (27%), Positives = 37/88 (42%), Gaps = 1/88 (1%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L AAC G+ D+++ L + N++ T L AA G + ++ L+E D A
Sbjct: 125 LRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKA 184
Query: 141 FREERARDVAARYSQTECV-EFLDWADA 167
A AA + V E + W A
Sbjct: 185 HCGATALHFAAEAGHIDIVKELIKWRAA 212
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 48.9 bits (115), Expect = 5e-06
Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 1/83 (1%)
Query: 82 YAACMAGQSDVIRALAKYGV-NLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
+ A G +++ L + GV N+NE+ G T +H AA G +E L+ L+++ D N
Sbjct: 241 HVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNITN 300
Query: 141 FREERARDVAARYSQTECVEFLD 163
ER DVA R++ V+ L+
Sbjct: 301 KAGERPSDVAKRFAHLAAVKLLE 323
Score = 44.7 bits (104), Expect = 9e-05
Identities = 27/81 (33%), Positives = 40/81 (49%)
Query: 82 YAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNF 141
+ A + GQ ++AL G NL + RG T LH AA G TL+ ++ VD +
Sbjct: 70 HIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDK 129
Query: 142 REERARDVAARYSQTECVEFL 162
RE R AA + + C++ L
Sbjct: 130 REWRPVHYAAFHGRLGCLQLL 150
Score = 37.0 bits (84), Expect = 0.018
Identities = 26/93 (27%), Positives = 43/93 (46%)
Query: 70 LLEEDIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKAL 129
L +D G L+ A G S ++ + + GV+ + R + +H AA GRL L+ L
Sbjct: 91 LTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLL 150
Query: 130 VELDVDIEALNFREERARDVAARYSQTECVEFL 162
V+ IE +++ +AA C +FL
Sbjct: 151 VKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFL 183
Score = 33.5 bits (75), Expect = 0.20
Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 4/90 (4%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALV----ELDVDI 136
++ A G+ ++ L K+G ++ + G +H AA G L K LV +
Sbjct: 135 VHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVL 194
Query: 137 EALNFREERARDVAARYSQTECVEFLDWAD 166
+A N E D+A R+ + ++F+ A+
Sbjct: 195 KAFNDNGENVLDLAQRFFKQNILQFIQGAE 224
Score = 28.1 bits (61), Expect = 8.3
Identities = 16/64 (25%), Positives = 33/64 (51%)
Query: 99 YGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTEC 158
+G ++ TTRG+T H AA G+ ++AL+ ++ A + R +AA + +
Sbjct: 54 HGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFT 113
Query: 159 VEFL 162
++ +
Sbjct: 114 LQIM 117
>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
[Homo sapiens]
Length = 567
Score = 48.5 bits (114), Expect = 6e-06
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 9/102 (8%)
Query: 39 LLQPALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAK 98
LL+ +L D E ++ ++ +P L ED G L+ C+ ++++ L
Sbjct: 72 LLEASLRNDAEEVRYFLKNKVSPD-------LCNED--GLTALHQCCIDNFEEIVKLLLS 122
Query: 99 YGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
+G N+N K +T LH AA G + +K LV+ D+ A+N
Sbjct: 123 HGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVN 164
Score = 37.0 bits (84), Expect = 0.018
Identities = 22/76 (28%), Positives = 34/76 (44%)
Query: 74 DIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELD 133
D G LL+ A G L +GV ++ K G+ LH AA WG+++ + LV
Sbjct: 226 DAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHG 285
Query: 134 VDIEALNFREERARDV 149
+ A +E D+
Sbjct: 286 ASLSARTSMDEMPIDL 301
Score = 30.0 bits (66), Expect = 2.2
Identities = 24/102 (23%), Positives = 47/102 (46%)
Query: 93 IRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAAR 152
I + G +L+ +G TLLH A A G L + L++ V ++ ++ AA
Sbjct: 212 IHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAF 271
Query: 153 YSQTECVEFLDWADARLTLKKYIAKVSLAVTDTEKGSGKLLK 194
+ Q + E L A L+ + + ++ + + + E+ LL+
Sbjct: 272 WGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLE 313
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 48.1 bits (113), Expect = 8e-06
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 7/107 (6%)
Query: 63 HEQAMQLLLEED-------IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H + +LLL++ + G L+ AC + V+ L KYG ++ T G T +H
Sbjct: 356 HYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIH 415
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
AA G L + L++ + N R E A +AAR Q E V L
Sbjct: 416 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Score = 47.8 bits (112), Expect = 1e-05
Identities = 34/137 (24%), Positives = 62/137 (45%), Gaps = 1/137 (0%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A +AGQ++V++ L K G N+N ++ G+T L+ AA ++ +K L+E +
Sbjct: 76 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
Query: 137 EALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSLAVTDTEKGSGKLLKED 196
VA + + V L D + ++ ++ DT K + LL+ D
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT-KSAALLLQND 194
Query: 197 KNTILSACRAKNEWLET 213
N + + N E+
Sbjct: 195 HNADVQSKMMVNRTTES 211
Score = 43.1 bits (100), Expect = 2e-04
Identities = 27/87 (31%), Positives = 36/87 (41%)
Query: 76 VGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVD 135
+G L AC G ++ L K G N+N KT GYT LH AA G + L++
Sbjct: 706 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
Query: 136 IEALNFREERARDVAARYSQTECVEFL 162
A A +A R V+ L
Sbjct: 766 PNATTANGNTALAIAKRLGYISVVDTL 792
Score = 39.7 bits (91), Expect = 0.003
Identities = 45/182 (24%), Positives = 72/182 (39%), Gaps = 6/182 (3%)
Query: 74 DIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELD 133
+I G L+ A AGQ +V+R L + G ++ + T LH A+ G+ E ++ L++
Sbjct: 440 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Query: 134 VDIEALNFREERARDVAARYSQTECVEFLDWADA--RLTLKKYIAKVSLAVTDTEKGSGK 191
+A ++AR Q + L A A L KK + +A K
Sbjct: 500 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 559
Query: 192 LLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQLEDIVTPIFTKMT--TPCQVKSA 249
LL + + SA KN H A + LE +P T TP + +
Sbjct: 560 LLLQRRAAADSA--GKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617
Query: 250 KS 251
K+
Sbjct: 618 KN 619
Score = 35.4 bits (80), Expect = 0.052
Identities = 29/111 (26%), Positives = 46/111 (41%), Gaps = 11/111 (9%)
Query: 63 HEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVN-----------LNEKTTRGY 111
H QA+ +LLE D G+ L A +A + D ++ A N +N T G+
Sbjct: 154 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 213
Query: 112 TLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
T LH AA +G + L+ ++ VA++ T V+ L
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Score = 35.4 bits (80), Expect = 0.052
Identities = 23/82 (28%), Positives = 34/82 (41%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G +D++ L G N++ T G T LH AA ++ L + D +A
Sbjct: 645 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 704
Query: 141 FREERARDVAARYSQTECVEFL 162
VA Y + V FL
Sbjct: 705 KLGYTPLIVACHYGNVKMVNFL 726
Score = 33.1 bits (74), Expect = 0.26
Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 6/104 (5%)
Query: 42 PALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGR------NLLYAACMAGQSDVIRA 95
P L GL + + H E LL + V L+ A G V +
Sbjct: 303 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 362
Query: 96 LAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEAL 139
L N N + G+T LH A R++ ++ LV+ I+A+
Sbjct: 363 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
Score = 32.7 bits (73), Expect = 0.34
Identities = 21/75 (28%), Positives = 34/75 (45%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A +G V+ L + G L +T G + LH AA +E +K L++ +
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 337
Query: 137 EALNFREERARDVAA 151
+ + A VAA
Sbjct: 338 DDVTLDYLTALHVAA 352
Score = 30.4 bits (67), Expect = 1.7
Identities = 17/60 (28%), Positives = 26/60 (43%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A Q + L YG N T +G T LH A+ G + + L++ +I
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Score = 29.3 bits (64), Expect = 3.7
Identities = 20/86 (23%), Positives = 36/86 (41%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A + +V L K+G + + T GYT L A +G ++ + L++ ++
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
Query: 137 EALNFREERARDVAARYSQTECVEFL 162
A AA+ T + L
Sbjct: 734 NAKTKNGYTPLHQAAQQGHTHIINVL 759
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 48.1 bits (113), Expect = 8e-06
Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 7/107 (6%)
Query: 63 HEQAMQLLLEED-------IVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLH 115
H + +LLL++ + G L+ AC + V+ L KYG ++ T G T +H
Sbjct: 377 HYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIH 436
Query: 116 CAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
AA G L + L++ + N R E A +AAR Q E V L
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Score = 47.8 bits (112), Expect = 1e-05
Identities = 34/137 (24%), Positives = 62/137 (45%), Gaps = 1/137 (0%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A +AGQ++V++ L K G N+N ++ G+T L+ AA ++ +K L+E +
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 137 EALNFREERARDVAARYSQTECVEFLDWADARLTLKKYIAKVSLAVTDTEKGSGKLLKED 196
VA + + V L D + ++ ++ DT K + LL+ D
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT-KSAALLLQND 215
Query: 197 KNTILSACRAKNEWLET 213
N + + N E+
Sbjct: 216 HNADVQSKMMVNRTTES 232
Score = 43.1 bits (100), Expect = 2e-04
Identities = 27/87 (31%), Positives = 36/87 (41%)
Query: 76 VGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVD 135
+G L AC G ++ L K G N+N KT GYT LH AA G + L++
Sbjct: 727 LGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Query: 136 IEALNFREERARDVAARYSQTECVEFL 162
A A +A R V+ L
Sbjct: 787 PNATTANGNTALAIAKRLGYISVVDTL 813
Score = 39.7 bits (91), Expect = 0.003
Identities = 45/182 (24%), Positives = 72/182 (39%), Gaps = 6/182 (3%)
Query: 74 DIVGRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELD 133
+I G L+ A AGQ +V+R L + G ++ + T LH A+ G+ E ++ L++
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 134 VDIEALNFREERARDVAARYSQTECVEFLDWADA--RLTLKKYIAKVSLAVTDTEKGSGK 191
+A ++AR Q + L A A L KK + +A K
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580
Query: 192 LLKEDKNTILSACRAKNEWLETHTEASINELFEQRQQLEDIVTPIFTKMT--TPCQVKSA 249
LL + + SA KN H A + LE +P T TP + +
Sbjct: 581 LLLQRRAAADSA--GKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Query: 250 KS 251
K+
Sbjct: 639 KN 640
Score = 35.4 bits (80), Expect = 0.052
Identities = 29/111 (26%), Positives = 46/111 (41%), Gaps = 11/111 (9%)
Query: 63 HEQAMQLLLEEDIVGRNLLYAACMAGQSDVIRALAKYGVN-----------LNEKTTRGY 111
H QA+ +LLE D G+ L A +A + D ++ A N +N T G+
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234
Query: 112 TLLHCAAAWGRLETLKALVELDVDIEALNFREERARDVAARYSQTECVEFL 162
T LH AA +G + L+ ++ VA++ T V+ L
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Score = 35.4 bits (80), Expect = 0.052
Identities = 23/82 (28%), Positives = 34/82 (41%)
Query: 81 LYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEALN 140
L+ A G +D++ L G N++ T G T LH AA ++ L + D +A
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 725
Query: 141 FREERARDVAARYSQTECVEFL 162
VA Y + V FL
Sbjct: 726 KLGYTPLIVACHYGNVKMVNFL 747
Score = 33.1 bits (74), Expect = 0.26
Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 6/104 (5%)
Query: 42 PALTGDVEGLQKIFEDPENPHHEQAMQLLLEEDIVGR------NLLYAACMAGQSDVIRA 95
P L GL + + H E LL + V L+ A G V +
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 96 LAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDIEAL 139
L N N + G+T LH A R++ ++ LV+ I+A+
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Score = 32.7 bits (73), Expect = 0.34
Identities = 21/75 (28%), Positives = 34/75 (45%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A +G V+ L + G L +T G + LH AA +E +K L++ +
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
Query: 137 EALNFREERARDVAA 151
+ + A VAA
Sbjct: 359 DDVTLDYLTALHVAA 373
Score = 30.4 bits (67), Expect = 1.7
Identities = 17/60 (28%), Positives = 26/60 (43%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A Q + L YG N T +G T LH A+ G + + L++ +I
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Score = 29.3 bits (64), Expect = 3.7
Identities = 20/86 (23%), Positives = 36/86 (41%)
Query: 77 GRNLLYAACMAGQSDVIRALAKYGVNLNEKTTRGYTLLHCAAAWGRLETLKALVELDVDI 136
G L+ A + +V L K+G + + T GYT L A +G ++ + L++ ++
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 137 EALNFREERARDVAARYSQTECVEFL 162
A AA+ T + L
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVL 780
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,032,753
Number of Sequences: 37866
Number of extensions: 433679
Number of successful extensions: 7176
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 358
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 4482
Number of HSP's gapped (non-prelim): 1923
length of query: 266
length of database: 18,247,518
effective HSP length: 100
effective length of query: 166
effective length of database: 14,460,918
effective search space: 2400512388
effective search space used: 2400512388
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.