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Search of human proteins with 38257146
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38257146 ankyrin repeat domain 46 [Homo sapiens]
(228 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38257146 ankyrin repeat domain 46 [Homo sapiens] 457 e-129
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 73 2e-13
gi|169208819 PREDICTED: similar to kinase D-interacting substrat... 70 1e-12
gi|169208593 PREDICTED: similar to kinase D-interacting substrat... 70 1e-12
gi|169208169 PREDICTED: similar to kinase D-interacting substrat... 70 1e-12
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 68 7e-12
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 68 7e-12
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 68 7e-12
gi|156142184 ankyrin repeat domain 39 [Homo sapiens] 67 1e-11
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 65 4e-11
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 65 4e-11
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 65 4e-11
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 65 5e-11
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 65 5e-11
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 65 6e-11
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 65 6e-11
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 64 8e-11
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 64 1e-10
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 63 2e-10
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 63 2e-10
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 62 3e-10
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 62 3e-10
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 62 4e-10
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 62 4e-10
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 62 4e-10
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 62 4e-10
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 62 4e-10
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 62 4e-10
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 61 7e-10
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 61 7e-10
>gi|38257146 ankyrin repeat domain 46 [Homo sapiens]
Length = 228
Score = 457 bits (1177), Expect = e-129
Identities = 228/228 (100%), Positives = 228/228 (100%)
Query: 1 MSYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDI 60
MSYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDI
Sbjct: 1 MSYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDI 60
Query: 61 CQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGV 120
CQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGV
Sbjct: 61 CQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGV 120
Query: 121 NKDVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFR 180
NKDVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFR
Sbjct: 121 NKDVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFR 180
Query: 181 TTWQEFVEDLGFWRVLLLIFVIALLSLGIAYYVSGVLPFVENQPELVH 228
TTWQEFVEDLGFWRVLLLIFVIALLSLGIAYYVSGVLPFVENQPELVH
Sbjct: 181 TTWQEFVEDLGFWRVLLLIFVIALLSLGIAYYVSGVLPFVENQPELVH 228
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 73.2 bits (178), Expect = 2e-13
Identities = 43/98 (43%), Positives = 52/98 (53%), Gaps = 3/98 (3%)
Query: 24 DFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALH 83
D ++LLE G DP D +GRT LH A+ GN I QLL GAD D GNT LH
Sbjct: 122 DVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLH 181
Query: 84 LC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRR 118
L HV I L+ G ++D + G TPL LAK +
Sbjct: 182 LAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
Score = 48.5 bits (114), Expect = 5e-06
Identities = 28/66 (42%), Positives = 36/66 (54%)
Query: 19 ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQG 78
A +G+ + LL+ G DPN RD G T LHLAA +V + L + GA + A D G
Sbjct: 150 ASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAG 209
Query: 79 NTALHL 84
T LHL
Sbjct: 210 RTPLHL 215
Score = 34.3 bits (77), Expect = 0.090
Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 52 AAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQG 108
+A +V+ Q L + GAD A D +G TALH G+ +Q L+ +G + + G
Sbjct: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
Query: 109 ATPLVLA 115
TPL LA
Sbjct: 177 NTPLHLA 183
>gi|169208819 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 70.5 bits (171), Expect = 1e-12
Identities = 43/100 (43%), Positives = 56/100 (56%), Gaps = 7/100 (7%)
Query: 27 YSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL---H 83
+ + LLE G N+RD RGRT L LA RG++D QLL +F D A D GN+ +
Sbjct: 66 FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
Query: 84 LCGHVDTIQFLVSN----GLKIDICNHQGATPLVLAKRRG 119
CGH ++FLV + GL++D N G T L LA RG
Sbjct: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
>gi|169208593 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 70.5 bits (171), Expect = 1e-12
Identities = 43/100 (43%), Positives = 56/100 (56%), Gaps = 7/100 (7%)
Query: 27 YSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL---H 83
+ + LLE G N+RD RGRT L LA RG++D QLL +F D A D GN+ +
Sbjct: 66 FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
Query: 84 LCGHVDTIQFLVSN----GLKIDICNHQGATPLVLAKRRG 119
CGH ++FLV + GL++D N G T L LA RG
Sbjct: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
>gi|169208169 PREDICTED: similar to kinase D-interacting substrate
220 [Homo sapiens]
Length = 380
Score = 70.5 bits (171), Expect = 1e-12
Identities = 43/100 (43%), Positives = 56/100 (56%), Gaps = 7/100 (7%)
Query: 27 YSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL---H 83
+ + LLE G N+RD RGRT L LA RG++D QLL +F D A D GN+ +
Sbjct: 66 FVRLLLEQGAAVNLRDERGRTALSLACERGHLDAVQLLVQFSGDPEAADSAGNSPVMWAA 125
Query: 84 LCGHVDTIQFLVSN----GLKIDICNHQGATPLVLAKRRG 119
CGH ++FLV + GL++D N G T L LA RG
Sbjct: 126 ACGHGAVLEFLVRSFRRLGLRLDRTNRAGLTALQLAAARG 165
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 67.8 bits (164), Expect = 7e-12
Identities = 45/118 (38%), Positives = 62/118 (52%), Gaps = 3/118 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G + + LLE G D N+ D +GRT L +AA G++ + L GA L +
Sbjct: 1107 PLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSL 1166
Query: 75 DYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
D +G +AL L GH +Q+LV G ID + G TPL LA G + V+ L+E
Sbjct: 1167 DKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1224
Score = 49.7 bits (117), Expect = 2e-06
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 3/105 (2%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
Q PL+ A +G + + LL G + D G + L A +G+ + Q L + GA
Sbjct: 1136 QGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA 1195
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPL 112
+ TD G T L L G +T+ +LV G I+ +H G PL
Sbjct: 1196 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1240
Score = 47.8 bits (112), Expect = 8e-06
Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 3/78 (3%)
Query: 45 GRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKI 101
G T L AA RG +++C+LL GA + T+ +G L GH ++ L+ G +
Sbjct: 1071 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1130
Query: 102 DICNHQGATPLVLAKRRG 119
++ + QG TPL++A G
Sbjct: 1131 NLSDKQGRTPLMVAACEG 1148
Score = 45.8 bits (107), Expect = 3e-05
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 3/110 (2%)
Query: 23 GDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL 82
G + LL G + + RG L AA +G+ I +LL + G D+ +D QG T L
Sbjct: 1082 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1141
Query: 83 HLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+ GH+ T++FL+S G + + +G + L A +G V L+E
Sbjct: 1142 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1191
Score = 39.3 bits (90), Expect = 0.003
Identities = 33/111 (29%), Positives = 53/111 (47%), Gaps = 5/111 (4%)
Query: 56 GNVDICQLLHKFGADLLATDYQGNTAL---HLCGHVDTIQFLVSNGLKIDICNHQGATPL 112
G+ ++ LL +FGA L T G TAL GH+ + L G+++D + +G L
Sbjct: 938 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
Query: 113 VLAKRRGVNKDVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHS 163
V + RG + D+++ L + E GT K +Q A + +A HS
Sbjct: 998 VHSALRG-HGDILQYLLTCEWSPGPP-QPGTLRKSHALQQALTAAASMGHS 1046
Score = 33.9 bits (76), Expect = 0.12
Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 8/90 (8%)
Query: 13 NVPLLQACIDGDFNYSK---RLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
N P+L C+ + + LLE G + G T L AAA G++ + LL K G
Sbjct: 927 NAPIL--CVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGV 984
Query: 70 DLLATDYQGNTAL---HLCGHVDTIQFLVS 96
+ D +G AL L GH D +Q+L++
Sbjct: 985 RVDHLDKKGQCALVHSALRGHGDILQYLLT 1014
Score = 33.1 bits (74), Expect = 0.20
Identities = 25/86 (29%), Positives = 38/86 (44%), Gaps = 3/86 (3%)
Query: 19 ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQG 78
AC+ G + L+E G + D GRT L LAA G+ + L + GA + D+ G
Sbjct: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
Query: 79 NTALHL---CGHVDTIQFLVSNGLKI 101
L C + + L+ G K+
Sbjct: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 67.8 bits (164), Expect = 7e-12
Identities = 45/118 (38%), Positives = 62/118 (52%), Gaps = 3/118 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G + + LLE G D N+ D +GRT L +AA G++ + L GA L +
Sbjct: 1115 PLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSL 1174
Query: 75 DYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
D +G +AL L GH +Q+LV G ID + G TPL LA G + V+ L+E
Sbjct: 1175 DKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVE 1232
Score = 49.7 bits (117), Expect = 2e-06
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 3/105 (2%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
Q PL+ A +G + + LL G + D G + L A +G+ + Q L + GA
Sbjct: 1144 QGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAA 1203
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPL 112
+ TD G T L L G +T+ +LV G I+ +H G PL
Sbjct: 1204 IDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1248
Score = 47.8 bits (112), Expect = 8e-06
Identities = 26/78 (33%), Positives = 42/78 (53%), Gaps = 3/78 (3%)
Query: 45 GRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKI 101
G T L AA RG +++C+LL GA + T+ +G L GH ++ L+ G +
Sbjct: 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1138
Query: 102 DICNHQGATPLVLAKRRG 119
++ + QG TPL++A G
Sbjct: 1139 NLSDKQGRTPLMVAACEG 1156
Score = 45.8 bits (107), Expect = 3e-05
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 3/110 (2%)
Query: 23 GDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL 82
G + LL G + + RG L AA +G+ I +LL + G D+ +D QG T L
Sbjct: 1090 GKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPL 1149
Query: 83 HLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+ GH+ T++FL+S G + + +G + L A +G V L+E
Sbjct: 1150 MVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVE 1199
Score = 39.3 bits (90), Expect = 0.003
Identities = 33/111 (29%), Positives = 53/111 (47%), Gaps = 5/111 (4%)
Query: 56 GNVDICQLLHKFGADLLATDYQGNTAL---HLCGHVDTIQFLVSNGLKIDICNHQGATPL 112
G+ ++ LL +FGA L T G TAL GH+ + L G+++D + +G L
Sbjct: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
Query: 113 VLAKRRGVNKDVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHS 163
V + RG + D+++ L + E GT K +Q A + +A HS
Sbjct: 1006 VHSALRG-HGDILQYLLTCEWSPGPP-QPGTLRKSHALQQALTAAASMGHS 1054
Score = 33.9 bits (76), Expect = 0.12
Identities = 29/90 (32%), Positives = 43/90 (47%), Gaps = 8/90 (8%)
Query: 13 NVPLLQACIDGDFNYSK---RLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
N P+L C+ + + LLE G + G T L AAA G++ + LL K G
Sbjct: 935 NAPIL--CVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGV 992
Query: 70 DLLATDYQGNTAL---HLCGHVDTIQFLVS 96
+ D +G AL L GH D +Q+L++
Sbjct: 993 RVDHLDKKGQCALVHSALRGHGDILQYLLT 1022
Score = 33.1 bits (74), Expect = 0.20
Identities = 25/86 (29%), Positives = 38/86 (44%), Gaps = 3/86 (3%)
Query: 19 ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQG 78
AC+ G + L+E G + D GRT L LAA G+ + L + GA + D+ G
Sbjct: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
Query: 79 NTALHL---CGHVDTIQFLVSNGLKI 101
L C + + L+ G K+
Sbjct: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 67.8 bits (164), Expect = 7e-12
Identities = 45/123 (36%), Positives = 67/123 (54%), Gaps = 3/123 (2%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G ++ +K L E+G + NI++ G T L A+ARG DI + L + GAD
Sbjct: 477 EEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGAD 536
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
L A D G+ ALHL ++ I+ L+S G +D + G TPL +A + G V+ L
Sbjct: 537 LNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVAL 596
Query: 128 LES 130
E+
Sbjct: 597 CEA 599
Score = 58.2 bits (139), Expect = 6e-09
Identities = 40/130 (30%), Positives = 63/130 (48%), Gaps = 5/130 (3%)
Query: 2 SYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDIC 61
S + V D +N + A G + K L E+ +++D G LH+AA G+ D+
Sbjct: 403 SRIDVQDKGGSNA-VYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVA 461
Query: 62 QLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRR 118
QLL FG++ D + T LH G+ + L G ++I N +G TPL+ A R
Sbjct: 462 QLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASAR 521
Query: 119 GVNKDVIRLL 128
G + D++ L
Sbjct: 522 GYH-DIVECL 530
Score = 54.3 bits (129), Expect = 8e-08
Identities = 44/126 (34%), Positives = 62/126 (49%), Gaps = 16/126 (12%)
Query: 6 VNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLH 65
+ND NVP LQ + NY D N + G L +AA GN+ I QLL
Sbjct: 352 INDD---NVPGLQHLLGSLSNY---------DVNQPNKHGTPPLLIAAGCGNIQILQLLI 399
Query: 66 KFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNK 122
K G+ + D G+ A++ GHVDT++FL N +D+ + G L +A R G +
Sbjct: 400 KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYG-HA 458
Query: 123 DVIRLL 128
DV +LL
Sbjct: 459 DVAQLL 464
Score = 47.8 bits (112), Expect = 8e-06
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PLL A G+ + L++ G +++D G ++ AA G+VD + L + L
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVK 441
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
D G ALH+ GH D Q L S G +I + + TPL A G
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHG 489
Score = 45.1 bits (105), Expect = 5e-05
Identities = 27/69 (39%), Positives = 36/69 (52%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
N PL AC DG+ L E+ + +I + GRT LHLAA G +D+ + L GA +
Sbjct: 578 NTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVE 637
Query: 73 ATDYQGNTA 81
A G TA
Sbjct: 638 ALTTDGKTA 646
Score = 43.5 bits (101), Expect = 1e-04
Identities = 34/113 (30%), Positives = 52/113 (46%), Gaps = 4/113 (3%)
Query: 29 KRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC--- 85
K LL G + +D G T LH+A GN+ I L + +L ++ G T LHL
Sbjct: 561 KTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANN 620
Query: 86 GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKG 138
G +D +++L G ++ G T LA R ++ V LL L + +G
Sbjct: 621 GILDVVRYLCLMGASVEALTTDGKTAEDLA-RSEQHEHVAGLLARLRKDTHRG 672
>gi|156142184 ankyrin repeat domain 39 [Homo sapiens]
Length = 183
Score = 67.4 bits (163), Expect = 1e-11
Identities = 41/113 (36%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 19 ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQG 78
A ++GD K L++ DP+ DS G T LH A+ G+ +CQ L + GA A + G
Sbjct: 38 AALNGDLGRVKHLIQKAEDPSQPDSAGYTALHYASRNGHYAVCQFLLESGAKCDAQTHGG 97
Query: 79 NTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
TALH CGH + + L+S+G + + G T L A RG + D+ LL
Sbjct: 98 ATALHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERG-HGDICSLL 149
Score = 39.3 bits (90), Expect = 0.003
Identities = 21/49 (42%), Positives = 27/49 (55%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
L +A G ++ LL G +P + D G T LH AA RG+ DIC LL
Sbjct: 101 LHRASYCGHTEIARLLLSHGSNPRVVDDDGMTSLHKAAERGHGDICSLL 149
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 65.5 bits (158), Expect = 4e-11
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 4/109 (3%)
Query: 23 GDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL 82
G + +K LL+ +PN R G T LH+A + + + +LL K+GA + A G T +
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 414
Query: 83 HLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
H+ GH++ + L+ NG D+ N +G T L +A R G +V+R L
Sbjct: 415 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG-QVEVVRCL 462
Score = 63.9 bits (154), Expect = 1e-10
Identities = 39/136 (28%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 6 VNDSSQTNVPLLQ-ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
+N +Q + L A +G + LL G + +G T LH+A+ G ++ ++L
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95
Query: 65 HKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVN 121
K GA++ A G T L++ H+D +++L+ NG G TPL +A ++G N
Sbjct: 96 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155
Query: 122 KDVIRLLESLEEQEVK 137
+ V LLE+ + +V+
Sbjct: 156 QAVAILLENDTKGKVR 171
Score = 62.0 bits (149), Expect = 4e-10
Identities = 40/122 (32%), Positives = 62/122 (50%), Gaps = 4/122 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S +N L+A G+ + L+ G D N + G LHLAA G+V + Q L G+
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 70 DLLATDYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIR 126
+ + +GNTALH L G + ++ LV G I+ + G TPL +A + + DV++
Sbjct: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN-HIDVVK 126
Query: 127 LL 128
L
Sbjct: 127 YL 128
Score = 56.2 bits (134), Expect = 2e-08
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
P+ A G N LL++G P++ + RG T LH+AA G V++ + L + GA + A
Sbjct: 413 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 472
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
+ T LH+ G + +Q L+ + D G TPL ++ R G
Sbjct: 473 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
Score = 56.2 bits (134), Expect = 2e-08
Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 10/120 (8%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LLE G P+ G T LH+AA + + I L +GA+ QG T LHL GH
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 653
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGTHSKL 147
D + L+ G I + G T L LA +D + + + L + G ++ H+KL
Sbjct: 654 TDMVTLLLDKGANIHMSTKSGLTSLHLA----AQEDKVNVADILTKH---GADQDAHTKL 706
Score = 55.5 bits (132), Expect = 4e-08
Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL AC + L++ G G T +H+AA G+++I LL + GA T
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 439
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ +G TALH+ G V+ ++ L+ NG +D + TPL +A R G + V LL+ +
Sbjct: 440 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Query: 132 EEQEVKGFN 140
+ N
Sbjct: 500 AHPDAATTN 508
Score = 55.1 bits (131), Expect = 5e-08
Identities = 49/162 (30%), Positives = 74/162 (45%), Gaps = 13/162 (8%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + LL G + NI +G T LHLA+ G+ D+ LL GA++ +
Sbjct: 611 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 670
Query: 75 DYQGNTALHLCGHVDTI---QFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T+LHL D + L +G D G TPL++A G K V LL+
Sbjct: 671 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-- 728
Query: 132 EEQEVKGFNRGTHSKLETMQTAESESAMESHS-LLNPNLQQG 172
+G N ++K + T ++A + H+ ++N LQ G
Sbjct: 729 -----QGAN--VNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 763
Score = 52.0 bits (123), Expect = 4e-07
Identities = 38/124 (30%), Positives = 59/124 (47%), Gaps = 10/124 (8%)
Query: 6 VNDSSQTNV-------PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNV 58
+N ++TN+ PL A +G + LL+ G + ++ G T LHLAA V
Sbjct: 628 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 687
Query: 59 DICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLA 115
++ +L K GAD A G T L + G+V + FL+ G ++ G TPL A
Sbjct: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
Query: 116 KRRG 119
++G
Sbjct: 748 AQQG 751
Score = 51.6 bits (122), Expect = 5e-07
Identities = 48/156 (30%), Positives = 68/156 (43%), Gaps = 12/156 (7%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G + +K LL+ + G T LH+AA N + LL + GA AT
Sbjct: 545 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 604
Query: 75 DYQGNTALHLCGHVDTIQF---LVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ + +Q L++ G + +I QG TPL LA + G V LL+
Sbjct: 605 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-- 662
Query: 132 EEQEVKGFN--RGTHSKLETMQTAESESAMESHSLL 165
KG N T S L ++ A E + +L
Sbjct: 663 -----KGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
Score = 51.2 bits (121), Expect = 7e-07
Identities = 38/103 (36%), Positives = 51/103 (49%), Gaps = 13/103 (12%)
Query: 30 RLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---G 86
R ESGF P LH+AA GNV++ LL GA + T G T LH+ G
Sbjct: 207 RTTESGFTP----------LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 256
Query: 87 HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+ + ++ L+ G +ID G TPL A R G ++ V LLE
Sbjct: 257 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299
Score = 48.5 bits (114), Expect = 5e-06
Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 17/124 (13%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G+ N K LL+ G + + G T LH AA G+ + +LL + GA LLA
Sbjct: 248 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 307
Query: 75 DYQGNTALHLCG---HVDTIQFLVSNGLKID--------------ICNHQGATPLVLAKR 117
G + LH+ HV+ ++ L+ + +D C H T L+L KR
Sbjct: 308 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 367
Query: 118 RGVN 121
N
Sbjct: 368 ANPN 371
Score = 47.8 bits (112), Expect = 8e-06
Identities = 34/116 (29%), Positives = 57/116 (49%), Gaps = 5/116 (4%)
Query: 8 DSSQTN--VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLH 65
D++ TN PL + +G + + LLE+G ++ +G T LH+AA G++D+ +LL
Sbjct: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Query: 66 KFGADLLATDYQGNTALHLCGHVDTIQ---FLVSNGLKIDICNHQGATPLVLAKRR 118
+ A + G T LH+ H D + L+ G G TPL +A ++
Sbjct: 563 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 618
Score = 46.6 bits (109), Expect = 2e-05
Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 4/118 (3%)
Query: 2 SYVFVNDSSQTN-VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDI 60
S + VN ++++ PL A G+ N + LL G + G T LH+A+ RGN ++
Sbjct: 201 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNM 260
Query: 61 CQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLA 115
+LL G + A G T LH GH ++ L+ G + G +PL +A
Sbjct: 261 VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 318
Score = 46.2 bits (108), Expect = 2e-05
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 3/97 (3%)
Query: 26 NYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC 85
N + L + G D + G T L +A GNV + L K GA++ A G T LH
Sbjct: 688 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
Query: 86 ---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
GH I L+ +G K + G T L +AKR G
Sbjct: 748 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 784
Score = 46.2 bits (108), Expect = 2e-05
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 3/83 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL+ AC G+ LL+ G + N + G T LH AA +G+ I +L + GA AT
Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 769
Query: 75 DYQGNTALHLC---GHVDTIQFL 94
GNTAL + G++ + L
Sbjct: 770 TANGNTALAIAKRLGYISVVDTL 792
Score = 45.8 bits (107), Expect = 3e-05
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 3/122 (2%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G + LL+ P+ + G T LH++A G VD+ +L + GA
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
+G T LH+ G +D + L+ D G TPL +A K + L
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594
Query: 128 LE 129
LE
Sbjct: 595 LE 596
Score = 39.3 bits (90), Expect = 0.003
Identities = 40/148 (27%), Positives = 66/148 (44%), Gaps = 28/148 (18%)
Query: 1 MSYVFVNDSSQTNV------PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRT---GLHL 51
+ Y+ N ++Q+ PL A G LLE+ D++G+ LH+
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRLPALHI 177
Query: 52 AAARGNVDICQLL--HKFGADLLA------TDYQGNTALHLCGH---VDTIQFLVSNGLK 100
AA + + LL + AD+ + T G T LH+ H V+ L++ G
Sbjct: 178 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 237
Query: 101 IDICNHQGATPLVLAKRRGVNKDVIRLL 128
+D G TPL +A +RG N ++++LL
Sbjct: 238 VDFTARNGITPLHVASKRG-NTNMVKLL 264
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 65.5 bits (158), Expect = 4e-11
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 4/109 (3%)
Query: 23 GDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL 82
G + +K LL+ +PN R G T LH+A + + + +LL K+GA + A G T +
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Query: 83 HLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
H+ GH++ + L+ NG D+ N +G T L +A R G +V+R L
Sbjct: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG-QVEVVRCL 483
Score = 63.9 bits (154), Expect = 1e-10
Identities = 39/136 (28%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 6 VNDSSQTNVPLLQ-ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
+N +Q + L A +G + LL G + +G T LH+A+ G ++ ++L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 65 HKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVN 121
K GA++ A G T L++ H+D +++L+ NG G TPL +A ++G N
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 122 KDVIRLLESLEEQEVK 137
+ V LLE+ + +V+
Sbjct: 177 QAVAILLENDTKGKVR 192
Score = 62.0 bits (149), Expect = 4e-10
Identities = 40/122 (32%), Positives = 62/122 (50%), Gaps = 4/122 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S +N L+A G+ + L+ G D N + G LHLAA G+V + Q L G+
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 70 DLLATDYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIR 126
+ + +GNTALH L G + ++ LV G I+ + G TPL +A + + DV++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN-HIDVVK 147
Query: 127 LL 128
L
Sbjct: 148 YL 149
Score = 56.2 bits (134), Expect = 2e-08
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
P+ A G N LL++G P++ + RG T LH+AA G V++ + L + GA + A
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
+ T LH+ G + +Q L+ + D G TPL ++ R G
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Score = 56.2 bits (134), Expect = 2e-08
Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 10/120 (8%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LLE G P+ G T LH+AA + + I L +GA+ QG T LHL GH
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGTHSKL 147
D + L+ G I + G T L LA +D + + + L + G ++ H+KL
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLA----AQEDKVNVADILTKH---GADQDAHTKL 727
Score = 55.5 bits (132), Expect = 4e-08
Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL AC + L++ G G T +H+AA G+++I LL + GA T
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ +G TALH+ G V+ ++ L+ NG +D + TPL +A R G + V LL+ +
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 132 EEQEVKGFN 140
+ N
Sbjct: 521 AHPDAATTN 529
Score = 55.1 bits (131), Expect = 5e-08
Identities = 49/162 (30%), Positives = 74/162 (45%), Gaps = 13/162 (8%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + LL G + NI +G T LHLA+ G+ D+ LL GA++ +
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 75 DYQGNTALHLCGHVDTI---QFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T+LHL D + L +G D G TPL++A G K V LL+
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-- 749
Query: 132 EEQEVKGFNRGTHSKLETMQTAESESAMESHS-LLNPNLQQG 172
+G N ++K + T ++A + H+ ++N LQ G
Sbjct: 750 -----QGAN--VNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784
Score = 52.0 bits (123), Expect = 4e-07
Identities = 38/124 (30%), Positives = 59/124 (47%), Gaps = 10/124 (8%)
Query: 6 VNDSSQTNV-------PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNV 58
+N ++TN+ PL A +G + LL+ G + ++ G T LHLAA V
Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 708
Query: 59 DICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLA 115
++ +L K GAD A G T L + G+V + FL+ G ++ G TPL A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 116 KRRG 119
++G
Sbjct: 769 AQQG 772
Score = 51.6 bits (122), Expect = 5e-07
Identities = 48/156 (30%), Positives = 68/156 (43%), Gaps = 12/156 (7%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G + +K LL+ + G T LH+AA N + LL + GA AT
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
Query: 75 DYQGNTALHLCGHVDTIQF---LVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ + +Q L++ G + +I QG TPL LA + G V LL+
Sbjct: 626 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-- 683
Query: 132 EEQEVKGFN--RGTHSKLETMQTAESESAMESHSLL 165
KG N T S L ++ A E + +L
Sbjct: 684 -----KGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 51.2 bits (121), Expect = 7e-07
Identities = 38/103 (36%), Positives = 51/103 (49%), Gaps = 13/103 (12%)
Query: 30 RLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---G 86
R ESGF P LH+AA GNV++ LL GA + T G T LH+ G
Sbjct: 228 RTTESGFTP----------LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 87 HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+ + ++ L+ G +ID G TPL A R G ++ V LLE
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Score = 48.5 bits (114), Expect = 5e-06
Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 17/124 (13%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G+ N K LL+ G + + G T LH AA G+ + +LL + GA LLA
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328
Query: 75 DYQGNTALHLCG---HVDTIQFLVSNGLKID--------------ICNHQGATPLVLAKR 117
G + LH+ HV+ ++ L+ + +D C H T L+L KR
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Query: 118 RGVN 121
N
Sbjct: 389 ANPN 392
Score = 47.8 bits (112), Expect = 8e-06
Identities = 34/116 (29%), Positives = 57/116 (49%), Gaps = 5/116 (4%)
Query: 8 DSSQTN--VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLH 65
D++ TN PL + +G + + LLE+G ++ +G T LH+AA G++D+ +LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 66 KFGADLLATDYQGNTALHLCGHVDTIQ---FLVSNGLKIDICNHQGATPLVLAKRR 118
+ A + G T LH+ H D + L+ G G TPL +A ++
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
Score = 46.6 bits (109), Expect = 2e-05
Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 4/118 (3%)
Query: 2 SYVFVNDSSQTN-VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDI 60
S + VN ++++ PL A G+ N + LL G + G T LH+A+ RGN ++
Sbjct: 222 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNM 281
Query: 61 CQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLA 115
+LL G + A G T LH GH ++ L+ G + G +PL +A
Sbjct: 282 VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 46.2 bits (108), Expect = 2e-05
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 3/97 (3%)
Query: 26 NYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC 85
N + L + G D + G T L +A GNV + L K GA++ A G T LH
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 86 ---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
GH I L+ +G K + G T L +AKR G
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Score = 46.2 bits (108), Expect = 2e-05
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 3/83 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL+ AC G+ LL+ G + N + G T LH AA +G+ I +L + GA AT
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 790
Query: 75 DYQGNTALHLC---GHVDTIQFL 94
GNTAL + G++ + L
Sbjct: 791 TANGNTALAIAKRLGYISVVDTL 813
Score = 45.8 bits (107), Expect = 3e-05
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 3/122 (2%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G + LL+ P+ + G T LH++A G VD+ +L + GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
+G T LH+ G +D + L+ D G TPL +A K + L
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 128 LE 129
LE
Sbjct: 616 LE 617
Score = 39.3 bits (90), Expect = 0.003
Identities = 40/148 (27%), Positives = 66/148 (44%), Gaps = 28/148 (18%)
Query: 1 MSYVFVNDSSQTNV------PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRT---GLHL 51
+ Y+ N ++Q+ PL A G LLE+ D++G+ LH+
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRLPALHI 198
Query: 52 AAARGNVDICQLL--HKFGADLLA------TDYQGNTALHLCGH---VDTIQFLVSNGLK 100
AA + + LL + AD+ + T G T LH+ H V+ L++ G
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258
Query: 101 IDICNHQGATPLVLAKRRGVNKDVIRLL 128
+D G TPL +A +RG N ++++LL
Sbjct: 259 VDFTARNGITPLHVASKRG-NTNMVKLL 285
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 65.5 bits (158), Expect = 4e-11
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 4/109 (3%)
Query: 23 GDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL 82
G + +K LL+ +PN R G T LH+A + + + +LL K+GA + A G T +
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Query: 83 HLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
H+ GH++ + L+ NG D+ N +G T L +A R G +V+R L
Sbjct: 436 HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAG-QVEVVRCL 483
Score = 63.9 bits (154), Expect = 1e-10
Identities = 39/136 (28%), Positives = 69/136 (50%), Gaps = 4/136 (2%)
Query: 6 VNDSSQTNVPLLQ-ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
+N +Q + L A +G + LL G + +G T LH+A+ G ++ ++L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 65 HKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVN 121
K GA++ A G T L++ H+D +++L+ NG G TPL +A ++G N
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 122 KDVIRLLESLEEQEVK 137
+ V LLE+ + +V+
Sbjct: 177 QAVAILLENDTKGKVR 192
Score = 62.0 bits (149), Expect = 4e-10
Identities = 40/122 (32%), Positives = 62/122 (50%), Gaps = 4/122 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S +N L+A G+ + L+ G D N + G LHLAA G+V + Q L G+
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 70 DLLATDYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIR 126
+ + +GNTALH L G + ++ LV G I+ + G TPL +A + + DV++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQEN-HIDVVK 147
Query: 127 LL 128
L
Sbjct: 148 YL 149
Score = 56.2 bits (134), Expect = 2e-08
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
P+ A G N LL++G P++ + RG T LH+AA G V++ + L + GA + A
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
+ T LH+ G + +Q L+ + D G TPL ++ R G
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Score = 56.2 bits (134), Expect = 2e-08
Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 10/120 (8%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LLE G P+ G T LH+AA + + I L +GA+ QG T LHL GH
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGTHSKL 147
D + L+ G I + G T L LA +D + + + L + G ++ H+KL
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLA----AQEDKVNVADILTKH---GADQDAHTKL 727
Score = 55.5 bits (132), Expect = 4e-08
Identities = 39/129 (30%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL AC + L++ G G T +H+AA G+++I LL + GA T
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ +G TALH+ G V+ ++ L+ NG +D + TPL +A R G + V LL+ +
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 132 EEQEVKGFN 140
+ N
Sbjct: 521 AHPDAATTN 529
Score = 55.1 bits (131), Expect = 5e-08
Identities = 49/162 (30%), Positives = 74/162 (45%), Gaps = 13/162 (8%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + LL G + NI +G T LHLA+ G+ D+ LL GA++ +
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 75 DYQGNTALHLCGHVDTI---QFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T+LHL D + L +G D G TPL++A G K V LL+
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-- 749
Query: 132 EEQEVKGFNRGTHSKLETMQTAESESAMESHS-LLNPNLQQG 172
+G N ++K + T ++A + H+ ++N LQ G
Sbjct: 750 -----QGAN--VNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784
Score = 52.0 bits (123), Expect = 4e-07
Identities = 38/124 (30%), Positives = 59/124 (47%), Gaps = 10/124 (8%)
Query: 6 VNDSSQTNV-------PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNV 58
+N ++TN+ PL A +G + LL+ G + ++ G T LHLAA V
Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKV 708
Query: 59 DICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLA 115
++ +L K GAD A G T L + G+V + FL+ G ++ G TPL A
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 116 KRRG 119
++G
Sbjct: 769 AQQG 772
Score = 51.6 bits (122), Expect = 5e-07
Identities = 48/156 (30%), Positives = 68/156 (43%), Gaps = 12/156 (7%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G + +K LL+ + G T LH+AA N + LL + GA AT
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
Query: 75 DYQGNTALHLCGHVDTIQF---LVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ + +Q L++ G + +I QG TPL LA + G V LL+
Sbjct: 626 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-- 683
Query: 132 EEQEVKGFN--RGTHSKLETMQTAESESAMESHSLL 165
KG N T S L ++ A E + +L
Sbjct: 684 -----KGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 51.2 bits (121), Expect = 7e-07
Identities = 38/103 (36%), Positives = 51/103 (49%), Gaps = 13/103 (12%)
Query: 30 RLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---G 86
R ESGF P LH+AA GNV++ LL GA + T G T LH+ G
Sbjct: 228 RTTESGFTP----------LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 87 HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+ + ++ L+ G +ID G TPL A R G ++ V LLE
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Score = 48.5 bits (114), Expect = 5e-06
Identities = 38/124 (30%), Positives = 55/124 (44%), Gaps = 17/124 (13%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G+ N K LL+ G + + G T LH AA G+ + +LL + GA LLA
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328
Query: 75 DYQGNTALHLCG---HVDTIQFLVSNGLKID--------------ICNHQGATPLVLAKR 117
G + LH+ HV+ ++ L+ + +D C H T L+L KR
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR 388
Query: 118 RGVN 121
N
Sbjct: 389 ANPN 392
Score = 47.8 bits (112), Expect = 8e-06
Identities = 34/116 (29%), Positives = 57/116 (49%), Gaps = 5/116 (4%)
Query: 8 DSSQTN--VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLH 65
D++ TN PL + +G + + LLE+G ++ +G T LH+AA G++D+ +LL
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 66 KFGADLLATDYQGNTALHLCGHVDTIQ---FLVSNGLKIDICNHQGATPLVLAKRR 118
+ A + G T LH+ H D + L+ G G TPL +A ++
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
Score = 46.6 bits (109), Expect = 2e-05
Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 4/118 (3%)
Query: 2 SYVFVNDSSQTN-VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDI 60
S + VN ++++ PL A G+ N + LL G + G T LH+A+ RGN ++
Sbjct: 222 SKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNM 281
Query: 61 CQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLA 115
+LL G + A G T LH GH ++ L+ G + G +PL +A
Sbjct: 282 VKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 46.2 bits (108), Expect = 2e-05
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 3/97 (3%)
Query: 26 NYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC 85
N + L + G D + G T L +A GNV + L K GA++ A G T LH
Sbjct: 709 NVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 86 ---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
GH I L+ +G K + G T L +AKR G
Sbjct: 769 AQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Score = 46.2 bits (108), Expect = 2e-05
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 3/83 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL+ AC G+ LL+ G + N + G T LH AA +G+ I +L + GA AT
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 790
Query: 75 DYQGNTALHLC---GHVDTIQFL 94
GNTAL + G++ + L
Sbjct: 791 TANGNTALAIAKRLGYISVVDTL 813
Score = 45.8 bits (107), Expect = 3e-05
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 3/122 (2%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G + LL+ P+ + G T LH++A G VD+ +L + GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
+G T LH+ G +D + L+ D G TPL +A K + L
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615
Query: 128 LE 129
LE
Sbjct: 616 LE 617
Score = 39.3 bits (90), Expect = 0.003
Identities = 40/148 (27%), Positives = 66/148 (44%), Gaps = 28/148 (18%)
Query: 1 MSYVFVNDSSQTNV------PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRT---GLHL 51
+ Y+ N ++Q+ PL A G LLE+ D++G+ LH+
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRLPALHI 198
Query: 52 AAARGNVDICQLL--HKFGADLLA------TDYQGNTALHLCGH---VDTIQFLVSNGLK 100
AA + + LL + AD+ + T G T LH+ H V+ L++ G
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258
Query: 101 IDICNHQGATPLVLAKRRGVNKDVIRLL 128
+D G TPL +A +RG N ++++LL
Sbjct: 259 VDFTARNGITPLHVASKRG-NTNMVKLL 285
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 65.1 bits (157), Expect = 5e-11
Identities = 44/101 (43%), Positives = 53/101 (52%), Gaps = 3/101 (2%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LL G DP IRD GR+ LH AAARG++ QLL GA++ A D G T LH GH
Sbjct: 255 LLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGH 314
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
V+ L+ G ++D TPL LA RG V LL
Sbjct: 315 VEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLL 355
Score = 59.3 bits (142), Expect = 3e-09
Identities = 44/118 (37%), Positives = 54/118 (45%), Gaps = 3/118 (2%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATD 75
LLQA G +LL G RD GRT LHLA RG+ + +LL + GA + A D
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 76 YQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLES 130
G TALH GH + L+ G + G TPL A G RLLE+
Sbjct: 105 RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
Score = 55.5 bits (132), Expect = 4e-08
Identities = 54/176 (30%), Positives = 72/176 (40%), Gaps = 13/176 (7%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATD 75
LL A G + LL G + RD G T L LAAA G ++L GAD D
Sbjct: 207 LLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRD 266
Query: 76 YQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLE 132
G +ALH GH+ +Q LV+ G ++D + G TPL A R G + LL+
Sbjct: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGA 326
Query: 133 EQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFRTTWQEFVE 188
+ + G+ R T L A E L G + RT W E +
Sbjct: 327 QVDATGWLRKTPLHL----------AAERGHGPTVGLLLSRGASPTLRTQWAEVAQ 372
Score = 43.1 bits (100), Expect = 2e-04
Identities = 40/118 (33%), Positives = 56/118 (47%), Gaps = 8/118 (6%)
Query: 15 PLLQACIDGDFNYSKRLLES-GFDP---NIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
PL A G + RLLE+ G P D+RG T H AAA G + + +LL GA
Sbjct: 143 PLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAG 202
Query: 71 LLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
L A G ++FL++ G ++D + GAT L LA G ++D+ LL
Sbjct: 203 LDGALLVAAAA----GRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLL 256
Score = 37.0 bits (84), Expect = 0.014
Identities = 25/69 (36%), Positives = 32/69 (46%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + G + LL+ G D GRT LH AA G+ + +LL + GA A
Sbjct: 77 PLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAAR 136
Query: 75 DYQGNTALH 83
G T LH
Sbjct: 137 SGTGLTPLH 145
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 65.1 bits (157), Expect = 5e-11
Identities = 47/127 (37%), Positives = 62/127 (48%), Gaps = 5/127 (3%)
Query: 8 DSSQTNV--PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLH 65
D+ Q N+ PL A G + LL+SG P+ D G LH AAARG IC++L
Sbjct: 521 DAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL 580
Query: 66 KFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNK 122
++GA L +QG T LHL GH++ I L + + TPL LA R G
Sbjct: 581 RYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEA 640
Query: 123 DVIRLLE 129
V LL+
Sbjct: 641 VVSALLQ 647
Score = 58.9 bits (141), Expect = 3e-09
Identities = 44/124 (35%), Positives = 63/124 (50%), Gaps = 6/124 (4%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + N ++ L+ DPN+ ++ G+T LH+AA G+V + +LL GA+L A
Sbjct: 464 PLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQ 523
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG---VNKDVIRLL 128
T LHL G V IQ L+ +G D + G PL A RG + K ++R
Sbjct: 524 QRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYG 583
Query: 129 ESLE 132
SLE
Sbjct: 584 ASLE 587
Score = 50.4 bits (119), Expect = 1e-06
Identities = 41/122 (33%), Positives = 56/122 (45%), Gaps = 4/122 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
++ PL A G + K L G + + + RT LHLA RG V Q L K GA
Sbjct: 492 AEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551
Query: 70 DLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIR 126
A D G LH G + L+ G +++ HQG TPL LA +G + ++I
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG-HLEIIH 610
Query: 127 LL 128
LL
Sbjct: 611 LL 612
Score = 47.0 bits (110), Expect = 1e-05
Identities = 44/152 (28%), Positives = 57/152 (37%), Gaps = 36/152 (23%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PLL A D + LL G D N D G LH AA G+ +LL GA + A
Sbjct: 398 PLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ 457
Query: 75 DYQGNTALHLC------------------------------------GHVDTIQFLVSNG 98
+ +G T LHL GHV ++ L S G
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
Query: 99 LKIDICNHQGATPLVLAKRRGVNKDVIRLLES 130
++D TPL LA RG + + LL+S
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549
Score = 45.8 bits (107), Expect = 3e-05
Identities = 38/119 (31%), Positives = 52/119 (43%), Gaps = 4/119 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL G + LL D + + + G T L +AA D+C LL GAD
Sbjct: 365 PLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRV 424
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLES 130
D G LH G T + L+ +G +D +G TPL LA + ++V RLL S
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNF-ENVARLLVS 482
Score = 45.1 bits (105), Expect = 5e-05
Identities = 35/106 (33%), Positives = 49/106 (46%), Gaps = 3/106 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G+ LL+ G DPN + G T LHLA R L + A++ A
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKR 117
+ G T HL G+ ++ LV G ++D+ + TPL LA R
Sbjct: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734
Score = 37.0 bits (84), Expect = 0.014
Identities = 35/117 (29%), Positives = 49/117 (41%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G L ES + + T LHLAA G + L + GAD A
Sbjct: 596 PLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAA 655
Query: 75 DYQGNTALHLCGHVDT---IQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
+ G T LHL T + L+ + + N G TP LA +G N ++++L
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKG-NTAILKVL 711
Score = 35.8 bits (81), Expect = 0.031
Identities = 45/179 (25%), Positives = 73/179 (40%), Gaps = 18/179 (10%)
Query: 11 QTNVPLLQACIDGDF-NYSKRLLESGFDPNI--RDSR------GRTGLHLAAARGNVDIC 61
+ N + Q +D D NY KR L+ N+ RD T LH A+G+V+
Sbjct: 319 EVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQV 378
Query: 62 QLLHKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRR 118
+LL D+ G T L + D L+++G + + G PL A +
Sbjct: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQN 438
Query: 119 GVNKDVIRLLE---SLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEG 174
G + LL+ ++ QE +G+ T L E+ + + +PNL + EG
Sbjct: 439 GDDGTARLLLDHGACVDAQEREGW---TPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 64.7 bits (156), Expect = 6e-11
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 3/109 (2%)
Query: 17 LQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDY 76
L AC GD + +LL G D N + G T LH A NVD+ + L + GA++ D
Sbjct: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
Query: 77 QGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNK 122
+G LH CG++D +FL+ G + N +G TPL +A+ + +
Sbjct: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEE 153
Score = 53.1 bits (126), Expect = 2e-07
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 9/112 (8%)
Query: 28 SKRLLESGFDPNIRDSR-GRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCG 86
+++ L SG ++R ++ G T LH+AAA+G ++ +LL + G D+ DY G T LH
Sbjct: 181 ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA 240
Query: 87 H---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQE 135
H + + LV N +++ N G T +A ++D++ LE L++++
Sbjct: 241 HWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-----DEDILGYLEELQKKQ 287
Score = 45.4 bits (106), Expect = 4e-05
Identities = 27/69 (39%), Positives = 41/69 (59%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATD 75
L QACID + + K L+E+G + N D+ G LH AA+ G +DI + L GA + A +
Sbjct: 77 LHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVN 136
Query: 76 YQGNTALHL 84
+G+T L +
Sbjct: 137 SEGDTPLDI 145
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 64.7 bits (156), Expect = 6e-11
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 3/109 (2%)
Query: 17 LQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDY 76
L AC GD + +LL G D N + G T LH A NVD+ + L + GA++ D
Sbjct: 45 LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDN 104
Query: 77 QGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNK 122
+G LH CG++D +FL+ G + N +G TPL +A+ + +
Sbjct: 105 EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEE 153
Score = 53.1 bits (126), Expect = 2e-07
Identities = 34/112 (30%), Positives = 62/112 (55%), Gaps = 9/112 (8%)
Query: 28 SKRLLESGFDPNIRDSR-GRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCG 86
+++ L SG ++R ++ G T LH+AAA+G ++ +LL + G D+ DY G T LH
Sbjct: 181 ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAA 240
Query: 87 H---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQE 135
H + + LV N +++ N G T +A ++D++ LE L++++
Sbjct: 241 HWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-----DEDILGYLEELQKKQ 287
Score = 45.4 bits (106), Expect = 4e-05
Identities = 27/69 (39%), Positives = 41/69 (59%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATD 75
L QACID + + K L+E+G + N D+ G LH AA+ G +DI + L GA + A +
Sbjct: 77 LHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVN 136
Query: 76 YQGNTALHL 84
+G+T L +
Sbjct: 137 SEGDTPLDI 145
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 64.3 bits (155), Expect = 8e-11
Identities = 50/158 (31%), Positives = 74/158 (46%), Gaps = 8/158 (5%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL A + G + L+ G N D G T LHLA +G + LL + A
Sbjct: 464 HTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAE 523
Query: 73 ATDYQGNTALHLC---GHVDTIQFLV---SNGLKIDICNHQGATPLVLAKRRGVNKDVIR 126
D GNT LHL GH D ++ LV ++DI N +G TPL +A R G +
Sbjct: 524 VQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIET 583
Query: 127 LLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSL 164
LL++ E++ NR + L+ ++ S ME++ L
Sbjct: 584 LLQNGASTEIQ--NRLKETPLKCALNSKILSVMEAYHL 619
Score = 62.8 bits (151), Expect = 2e-10
Identities = 40/119 (33%), Positives = 65/119 (54%), Gaps = 6/119 (5%)
Query: 14 VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLA 73
VPL AC G F K LL+S PN +D G T L A + G+ ++ LL + GA + A
Sbjct: 779 VPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINA 838
Query: 74 TDYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
++ +GNTALH + HV ++ L+ +G + + N + T + A++ N ++ LL+
Sbjct: 839 SNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQ---NSKIMELLQ 894
Score = 47.4 bits (111), Expect = 1e-05
Identities = 40/135 (29%), Positives = 59/135 (43%), Gaps = 18/135 (13%)
Query: 34 SGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GHVDT 90
SG N+ G + LH+AA G D+ LL K GA+ A + LHL GH
Sbjct: 733 SGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQV 792
Query: 91 IQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE---SLEEQEVKGFNRGTHSKL 147
++ L+ + K + + G TPL+ A G ++ V LL+ S+ KG
Sbjct: 793 VKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKG--------- 843
Query: 148 ETMQTAESESAMESH 162
TA E+ +E H
Sbjct: 844 ---NTALHEAVIEKH 855
Score = 43.5 bits (101), Expect = 1e-04
Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 6 VNDSSQT-NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN +SQ + PL A + G + LL+ G + R++ LHLA +G+ + + L
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
Query: 65 HKFGADLLATDYQGNTAL-HLC--GHVDTIQFLVSNGLKIDICNHQGATPL 112
A D GNT L + C GH + + L+ +G I+ N++G T L
Sbjct: 797 LDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTAL 847
Score = 38.9 bits (89), Expect = 0.004
Identities = 22/70 (31%), Positives = 34/70 (48%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
N PL+ AC G LL+ G N +++G T LH A +V + +LL GA +
Sbjct: 811 NTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQ 870
Query: 73 ATDYQGNTAL 82
+ + TA+
Sbjct: 871 VLNKRQRTAV 880
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 63.5 bits (153), Expect = 1e-10
Identities = 40/122 (32%), Positives = 59/122 (48%), Gaps = 14/122 (11%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LL+ G P+ G T LH+AA + +DI L ++GAD A QG ++HL GH
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH 676
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGTHSKL 147
VD + L+ +++ N G TPL LA +D + + E L N+G H
Sbjct: 677 VDMVSLLLGRNANVNLSNKSGLTPLHLA----AQEDRVNVAEVL-------VNQGAHVDA 725
Query: 148 ET 149
+T
Sbjct: 726 QT 727
Score = 62.4 bits (150), Expect = 3e-10
Identities = 38/122 (31%), Positives = 65/122 (53%), Gaps = 4/122 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S N L+A G + +++G D NI + G LHLA+ G+V++ L + A
Sbjct: 39 SDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREA 98
Query: 70 DLLATDYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIR 126
++ A +GNTALH L G + ++ LV+NG ++ + G TPL +A + + +V++
Sbjct: 99 NVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQEN-HLEVVK 157
Query: 127 LL 128
L
Sbjct: 158 FL 159
Score = 60.1 bits (144), Expect = 2e-09
Identities = 48/155 (30%), Positives = 67/155 (43%), Gaps = 12/155 (7%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
P+ A G N +L+ G PN + RG T LH+AA G ++ + L + GA + A
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL--- 128
T LH+ G D +Q L+ G + G TPL L+ R G ++DV L
Sbjct: 496 AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG-HEDVAAFLLDH 554
Query: 129 -ESLEEQEVKGFN----RGTHSKLETMQTAESESA 158
SL KGF + KLE +SA
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Score = 58.5 bits (140), Expect = 4e-09
Identities = 36/118 (30%), Positives = 60/118 (50%), Gaps = 3/118 (2%)
Query: 23 GDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL 82
G + +K LL+ +PN + G T LH+A + + + +LL K GA + A G T +
Sbjct: 378 GHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPI 437
Query: 83 HLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVK 137
H+ GHV+ + L+ +G + N +G T L +A R G + V L++ + E K
Sbjct: 438 HVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495
Score = 57.0 bits (136), Expect = 1e-08
Identities = 37/138 (26%), Positives = 70/138 (50%), Gaps = 4/138 (2%)
Query: 4 VFVNDSSQTNVPLLQ-ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQ 62
V +N +Q + L A +G LL+ + + +G T LH+A+ G ++ +
Sbjct: 65 VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVK 124
Query: 63 LLHKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
+L GA++ A G T L++ H++ ++FL+ NG + G TPL +A ++G
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQG 184
Query: 120 VNKDVIRLLESLEEQEVK 137
++ V LLE+ + +V+
Sbjct: 185 HDQVVSLLLENDTKGKVR 202
Score = 53.5 bits (127), Expect = 1e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 3/118 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL AC + LL+ G G T +H+AA G+V+I L GA T
Sbjct: 403 PLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT 462
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+ +G TALH+ G + +++LV +G +++ TPL ++ R G V +LL+
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520
Score = 52.8 bits (125), Expect = 2e-07
Identities = 45/160 (28%), Positives = 74/160 (46%), Gaps = 13/160 (8%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + + LLE G D N +G +HLAA G+VD+ LL A++ +
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLS 693
Query: 75 DYQGNTALHLCGHVDTI---QFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LHL D + + LV+ G +D G TPL + G + I+++ L
Sbjct: 694 NKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV----GCHYGNIKIVNFL 749
Query: 132 EEQEVKGFNRGTHSKLETMQTAESESAMESHS-LLNPNLQ 170
+ K ++K + T ++A + H+ ++N LQ
Sbjct: 750 LQHSAK-----VNAKTKNGYTPLHQAAQQGHTHIINVLLQ 784
Score = 49.7 bits (117), Expect = 2e-06
Identities = 39/134 (29%), Positives = 63/134 (47%), Gaps = 5/134 (3%)
Query: 1 MSYVFVNDSS-QTNVPLLQ-ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNV 58
+S + ND+ + +P L A D + LL++ + ++ G T LH+AA GN+
Sbjct: 189 VSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI 248
Query: 59 DICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLA 115
++ LL A + T T LH+ G+ + ++ L+ G KID G TPL
Sbjct: 249 NVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG 308
Query: 116 KRRGVNKDVIRLLE 129
R G + V LL+
Sbjct: 309 ARSGHEQVVEMLLD 322
Score = 47.0 bits (110), Expect = 1e-05
Identities = 45/169 (26%), Positives = 70/169 (41%), Gaps = 13/169 (7%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL + +G + + LL+ G +I +G T LH+AA G +++ LL + A A
Sbjct: 535 PLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAA 594
Query: 75 DYQGNTALHLCGHVDTIQ---FLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ H D + L+ G G TPL +A ++ LLE
Sbjct: 595 GKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Query: 132 EEQEVKGFNRGTHSKLETMQTAESESAMESHSLL-----NPNLQQGEGV 175
+ N T + ++ A E ++ SLL N NL G+
Sbjct: 655 ADA-----NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
Score = 40.8 bits (94), Expect = 0.001
Identities = 35/124 (28%), Positives = 55/124 (44%), Gaps = 4/124 (3%)
Query: 8 DSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKF 67
+S PL A G+ N + LL + T LH+A+ RGN ++ +LL
Sbjct: 231 ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR 290
Query: 68 GADLLATDYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
GA + A G T LH GH ++ L+ I G +PL +A +G + +
Sbjct: 291 GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA-TQGDHLNC 349
Query: 125 IRLL 128
++LL
Sbjct: 350 VQLL 353
Score = 34.3 bits (77), Expect = 0.090
Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 3/126 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL C G+ LL+ N + G T LH AA +G+ I +L + A
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Query: 75 DYQGNTALHLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQ 134
GNTAL + + I V + LKI + T V K + + + + + +
Sbjct: 793 TVNGNTALGIARRLGYIS--VVDTLKI-VTEETMTTTTVTEKHKMNVPETMNEVLDMSDD 849
Query: 135 EVKGFN 140
EV+ N
Sbjct: 850 EVRKAN 855
Score = 32.7 bits (73), Expect = 0.26
Identities = 16/44 (36%), Positives = 24/44 (54%)
Query: 86 GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
GH++ + NG+ I+ICN G L LA + G + V LL+
Sbjct: 52 GHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQ 95
Score = 32.3 bits (72), Expect = 0.34
Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 3/76 (3%)
Query: 47 TGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDI 103
T LH+AA G+ + ++L A+ A G T LH+ + ++ L+ +G I
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 104 CNHQGATPLVLAKRRG 119
G TP+ +A G
Sbjct: 429 VTESGLTPIHVAAFMG 444
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 62.8 bits (151), Expect = 2e-10
Identities = 43/125 (34%), Positives = 67/125 (53%), Gaps = 7/125 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFD---PNIRDSRGRTGLHLAAARGNVDICQLLHKFGADL 71
PL++A G + LL+ G D P + SR T L +AA +G+ C+LL GA +
Sbjct: 1288 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD-TALTIAADKGHYKFCELLIGRGAHI 1346
Query: 72 LATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
+ +GNT L L GH+D +Q LV G +D +++ TPL+ A R+G K V L+
Sbjct: 1347 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Query: 129 ESLEE 133
+ + +
Sbjct: 1407 KEVNQ 1411
Score = 56.2 bits (134), Expect = 2e-08
Identities = 49/152 (32%), Positives = 70/152 (46%), Gaps = 13/152 (8%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL+ A G K LL D N + S G T L A A G VD+ ++L + GA +
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
Query: 75 DYQGNTAL---HLCGHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRGVNKDVIRLLES 130
+ G+T L GHV+ + L+ NG I+ N + L LA +G + V LLE+
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA 423
Query: 131 LEEQEVKGFNRGTHSKLETMQTAESESAMESH 162
+QE K + M TA E+ M+ H
Sbjct: 424 GADQE---------HKTDEMHTALMEACMDGH 446
Score = 53.5 bits (127), Expect = 1e-07
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 3/116 (2%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA--DLLA 73
L AC G + LLE+G D + T L A G+V++ +LL GA ++ A
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
Query: 74 TDYQGNTALHLCG-HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ L CG HV+ L+ G ++ N +G TPL+ A R G + V LL
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Score = 52.0 bits (123), Expect = 4e-07
Identities = 31/93 (33%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL++A +G K LL +G + + + G T L A G+ D+ +L + GADL
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 73 ATDYQGNTAL---HLCGHVDTIQFLVSNGLKID 102
G T L GHV T+QFL+S G ++
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Score = 49.7 bits (117), Expect = 2e-06
Identities = 48/159 (30%), Positives = 65/159 (40%), Gaps = 38/159 (23%)
Query: 7 NDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGR-------------------- 46
N N L +AC +GD N ++LL G N G
Sbjct: 229 NAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 288
Query: 47 --------------TGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL-HLC--GHVD 89
T L AA G+V I +LL AD+ A GNTAL + C G+VD
Sbjct: 289 MHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD 348
Query: 90 TIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ L+ +G I+ N G TPL+ A G + +V RLL
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAG-HVEVARLL 386
Score = 47.4 bits (111), Expect = 1e-05
Identities = 45/142 (31%), Positives = 64/142 (45%), Gaps = 9/142 (6%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S + L AC G + LLE G RD +G T L LAA G+V + ++L GA
Sbjct: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 1140
Query: 70 DLLA-TDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVI 125
D+ A ++ +T L L G + ++ L++ G + N TPL LA G +
Sbjct: 1141 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1200
Query: 126 RLLESLEEQEVKGFNRGTHSKL 147
LL + E N T SKL
Sbjct: 1201 ILLNAGAE-----INSRTGSKL 1217
Score = 47.4 bits (111), Expect = 1e-05
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 3/89 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S + L A G + + + L+ G ++R+ +G T L LAA G++D+ QLL + GA
Sbjct: 1318 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1377
Query: 70 DLLATDYQGNTALHLC---GHVDTIQFLV 95
D+ A D + T L GHV +++LV
Sbjct: 1378 DVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 47.0 bits (110), Expect = 1e-05
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 3/97 (3%)
Query: 9 SSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFG 68
+ + + L++AC+DG ++ LL+SG N+ + L LAA G+V++ LL + G
Sbjct: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
Query: 69 ADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKID 102
A L + +G T L GH + + L+ G I+
Sbjct: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Score = 43.5 bits (101), Expect = 1e-04
Identities = 37/124 (29%), Positives = 61/124 (49%), Gaps = 5/124 (4%)
Query: 9 SSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFG 68
SS N L AC G + K LLESG + G T L A + G+V++ +LL + G
Sbjct: 331 SSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENG 390
Query: 69 ADL--LATDYQGNTALHLC--GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
A + + +++ + C GH++ ++FL+ G + + T L+ A G + +V
Sbjct: 391 AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDG-HVEV 449
Query: 125 IRLL 128
RLL
Sbjct: 450 ARLL 453
Score = 41.2 bits (95), Expect = 7e-04
Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 4/118 (3%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADL-LAT 74
L AC +G + + LL++G D GRT L AA G+V Q L GA++ T
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+T L L GH+ ++ L+++G G+T L+ A + G V LL+
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 34.7 bits (78), Expect = 0.069
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLA- 73
PL A G + L+E G + G T L AA G+ ++ LL GA++ A
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 74 TDYQGNTALHLC---GHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRG 119
T+ TAL L G ++ FL+ G I++ C +TPL+ A + G
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGADIELGC----STPLMEAAQEG 575
Score = 28.5 bits (62), Expect = 5.0
Identities = 17/54 (31%), Positives = 28/54 (51%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHK 66
N PL A G + + L+++G D + D+R T L A +G+V + + L K
Sbjct: 1354 NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 62.8 bits (151), Expect = 2e-10
Identities = 43/125 (34%), Positives = 67/125 (53%), Gaps = 7/125 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFD---PNIRDSRGRTGLHLAAARGNVDICQLLHKFGADL 71
PL++A G + LL+ G D P + SR T L +AA +G+ C+LL GA +
Sbjct: 1037 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD-TALTIAADKGHYKFCELLIGRGAHI 1095
Query: 72 LATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
+ +GNT L L GH+D +Q LV G +D +++ TPL+ A R+G K V L+
Sbjct: 1096 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
Query: 129 ESLEE 133
+ + +
Sbjct: 1156 KEVNQ 1160
Score = 56.2 bits (134), Expect = 2e-08
Identities = 49/152 (32%), Positives = 70/152 (46%), Gaps = 13/152 (8%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL+ A G K LL D N + S G T L A A G VD+ ++L + GA +
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDH 363
Query: 75 DYQGNTAL---HLCGHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRGVNKDVIRLLES 130
+ G+T L GHV+ + L+ NG I+ N + L LA +G + V LLE+
Sbjct: 364 NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEA 423
Query: 131 LEEQEVKGFNRGTHSKLETMQTAESESAMESH 162
+QE K + M TA E+ M+ H
Sbjct: 424 GADQE---------HKTDEMHTALMEACMDGH 446
Score = 53.5 bits (127), Expect = 1e-07
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 3/116 (2%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA--DLLA 73
L AC G + LLE+G D + T L A G+V++ +LL GA ++ A
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
Query: 74 TDYQGNTALHLCG-HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ L CG HV+ L+ G ++ N +G TPL+ A R G + V LL
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Score = 52.0 bits (123), Expect = 4e-07
Identities = 31/93 (33%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL++A +G K LL +G + + + G T L A G+ D+ +L + GADL
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 73 ATDYQGNTAL---HLCGHVDTIQFLVSNGLKID 102
G T L GHV T+QFL+S G ++
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657
Score = 49.7 bits (117), Expect = 2e-06
Identities = 48/159 (30%), Positives = 65/159 (40%), Gaps = 38/159 (23%)
Query: 7 NDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGR-------------------- 46
N N L +AC +GD N ++LL G N G
Sbjct: 229 NAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA 288
Query: 47 --------------TGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL-HLC--GHVD 89
T L AA G+V I +LL AD+ A GNTAL + C G+VD
Sbjct: 289 MHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD 348
Query: 90 TIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ L+ +G I+ N G TPL+ A G + +V RLL
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAG-HVEVARLL 386
Score = 47.4 bits (111), Expect = 1e-05
Identities = 45/142 (31%), Positives = 64/142 (45%), Gaps = 9/142 (6%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S + L AC G + LLE G RD +G T L LAA G+V + ++L GA
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 70 DLLA-TDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVI 125
D+ A ++ +T L L G + ++ L++ G + N TPL LA G +
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
Query: 126 RLLESLEEQEVKGFNRGTHSKL 147
LL + E N T SKL
Sbjct: 950 ILLNAGAE-----INSRTGSKL 966
Score = 47.4 bits (111), Expect = 1e-05
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 3/89 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S + L A G + + + L+ G ++R+ +G T L LAA G++D+ QLL + GA
Sbjct: 1067 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1126
Query: 70 DLLATDYQGNTALHLC---GHVDTIQFLV 95
D+ A D + T L GHV +++LV
Sbjct: 1127 DVDAADNRKITPLMAAFRKGHVKVVRYLV 1155
Score = 47.0 bits (110), Expect = 1e-05
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 3/97 (3%)
Query: 9 SSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFG 68
+ + + L++AC+DG ++ LL+SG N+ + L LAA G+V++ LL + G
Sbjct: 431 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 490
Query: 69 ADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKID 102
A L + +G T L GH + + L+ G I+
Sbjct: 491 ASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Score = 43.5 bits (101), Expect = 1e-04
Identities = 37/124 (29%), Positives = 61/124 (49%), Gaps = 5/124 (4%)
Query: 9 SSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFG 68
SS N L AC G + K LLESG + G T L A + G+V++ +LL + G
Sbjct: 331 SSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENG 390
Query: 69 ADL--LATDYQGNTALHLC--GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
A + + +++ + C GH++ ++FL+ G + + T L+ A G + +V
Sbjct: 391 AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDG-HVEV 449
Query: 125 IRLL 128
RLL
Sbjct: 450 ARLL 453
Score = 41.2 bits (95), Expect = 7e-04
Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 4/118 (3%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADL-LAT 74
L AC +G + + LL++G D GRT L AA G+V Q L GA++ T
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+T L L GH+ ++ L+++G G+T L+ A + G V LL+
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 34.7 bits (78), Expect = 0.069
Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLA- 73
PL A G + L+E G + G T L AA G+ ++ LL GA++ A
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 74 TDYQGNTALHLC---GHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRG 119
T+ TAL L G ++ FL+ G I++ C +TPL+ A + G
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGADIELGC----STPLMEAAQEG 575
Score = 28.5 bits (62), Expect = 5.0
Identities = 17/54 (31%), Positives = 28/54 (51%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHK 66
N PL A G + + L+++G D + D+R T L A +G+V + + L K
Sbjct: 1103 NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 62.4 bits (150), Expect = 3e-10
Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 26/170 (15%)
Query: 15 PLLQACIDGDFNYSKRLLESGFD---PNIRDSRGRTGLHLAAARGNVDICQLLHKFGADL 71
PL++A G + LL+ G D P + SR T L +AA +G+ C+LL GA +
Sbjct: 1260 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD-TALTIAADKGHYKFCELLIHRGAHI 1318
Query: 72 LATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG--------- 119
+ +GNT L L GH D +Q LV G +D +++ TPL+ A R+G
Sbjct: 1319 DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Query: 120 --VNK-----DVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESH 162
VN+ + +R + ++ ++E+ + H +ET+ A+ + A E++
Sbjct: 1379 KEVNQFPSDIECMRYIATITDKELL---KKCHQCVETIVKAKDQQAAEAN 1425
Score = 54.3 bits (129), Expect = 8e-08
Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 11/141 (7%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA--DLLA 73
L AC G + + LLE+G D + T L A G+V++ +LL GA ++ A
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 435
Query: 74 TDYQGNTALHLCG-HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLE 132
++ L CG HV+ L+ G ++ N +G TPL+ A R G + V LL
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL---- 491
Query: 133 EQEVKGFNRGTHSKLETMQTA 153
+G N ++ ET +TA
Sbjct: 492 ---AQGANINAQTE-ETQETA 508
Score = 52.4 bits (124), Expect = 3e-07
Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 3/119 (2%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL++A +G K LL SG + + + G T L A G+ D+ +L + GADL
Sbjct: 536 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Query: 73 ATDYQGNTAL---HLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
G T L GH+ T+QFL+S G ++ +V G + V+ LL
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELL 654
Score = 51.6 bits (122), Expect = 5e-07
Identities = 49/153 (32%), Positives = 74/153 (48%), Gaps = 15/153 (9%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL+ A G + K LL D N + + G T L A A G VDI ++L GA++
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334
Query: 75 DYQGNTAL---HLCGHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRGVNKDVIR-LLE 129
+ G+T L GHV+ + L+ +G I+ N + L LA +G + D++R LLE
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG-HLDMVRFLLE 393
Query: 130 SLEEQEVKGFNRGTHSKLETMQTAESESAMESH 162
+ +QE K + M TA E+ M+ H
Sbjct: 394 AGADQE---------HKTDEMHTALMEACMDGH 417
Score = 48.5 bits (114), Expect = 5e-06
Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 38/150 (25%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAA-------------------RG 56
L +AC DGD N ++LL+ G N G + L LA + RG
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 57 N---------------VDICQLLHKFGADLLATDYQGNTAL-HLC--GHVDTIQFLVSNG 98
N +DI +LL AD+ + GNTAL + C G VD ++ L++ G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 99 LKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
I+ N G TPL+ A G + +V R+L
Sbjct: 329 ANIEDHNENGHTPLMEAASAG-HVEVARVL 357
Score = 47.8 bits (112), Expect = 8e-06
Identities = 29/97 (29%), Positives = 52/97 (53%), Gaps = 3/97 (3%)
Query: 9 SSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFG 68
+ + + L++AC+DG ++ LL+SG N+ + L LAA G+V++ LL + G
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
Query: 69 ADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKID 102
A+L + +G T L GH + + L++ G I+
Sbjct: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 47.4 bits (111), Expect = 1e-05
Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 3/89 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S + L A G + + + L+ G ++R+ +G T L LA+ G+ D+ QLL + GA
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 70 DLLATDYQGNTALHLC---GHVDTIQFLV 95
D+ A D + T L GHV +Q+LV
Sbjct: 1350 DVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 43.9 bits (102), Expect = 1e-04
Identities = 38/128 (29%), Positives = 62/128 (48%), Gaps = 6/128 (4%)
Query: 6 VNDSSQT-NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN S T N L AC G + K LL G + + G T L AA+ G+V++ ++L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 357
Query: 65 --HKFGADLLATDYQGNTALHLC--GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGV 120
H G + + +++ + C GH+D ++FL+ G + + T L+ A G
Sbjct: 358 LDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG- 416
Query: 121 NKDVIRLL 128
+ +V RLL
Sbjct: 417 HVEVARLL 424
Score = 37.7 bits (86), Expect = 0.008
Identities = 41/142 (28%), Positives = 59/142 (41%), Gaps = 9/142 (6%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S + L AC G L+ RD +G T L LAA G+V + ++L G
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
Query: 70 DLLA-TDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVI 125
D+ A ++ +T L L G + + L++ G + N TPL LA G +
Sbjct: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172
Query: 126 RLLESLEEQEVKGFNRGTHSKL 147
LL + E N T SKL
Sbjct: 1173 ILLNAGAE-----INSRTGSKL 1189
Score = 35.0 bits (79), Expect = 0.053
Identities = 38/121 (31%), Positives = 56/121 (46%), Gaps = 9/121 (7%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLA- 73
PL A G + L+E G + + G T L AA G+ ++ LL GA++ A
Sbjct: 441 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
Query: 74 TDYQGNTALHLC---GHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRGVNKDVIRLLE 129
T+ TAL L G + FL+ G I++ C +TPL+ A + G + V LL
Sbjct: 501 TEETQETALTLACCGGFSEVADFLIKAGADIELGC----STPLMEASQEGHLELVKYLLA 556
Query: 130 S 130
S
Sbjct: 557 S 557
Score = 34.3 bits (77), Expect = 0.090
Identities = 50/193 (25%), Positives = 75/193 (38%), Gaps = 10/193 (5%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL AC G LL G + R+ T L LAA+ G V+I ++L GA++
Sbjct: 1123 DTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182
Query: 73 AT--DYQGNTALHLC---GHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRGVNKDVIR 126
+ G + L L GHV ++ L+ G I+ T L LA +G + V
Sbjct: 1183 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSL 1242
Query: 127 LLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFRTTWQEF 186
LL+ E +R M+ A A LL+ + S R T
Sbjct: 1243 LLDRKANVE----HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
Query: 187 VEDLGFWRVLLLI 199
D G ++ L+
Sbjct: 1299 AADKGHYKFCELL 1311
Score = 31.6 bits (70), Expect = 0.59
Identities = 19/54 (35%), Positives = 29/54 (53%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHK 66
N PL A G F+ + L+++G D + D+R T L A +G+V + Q L K
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 30.0 bits (66), Expect = 1.7
Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 3/49 (6%)
Query: 74 TDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
T+ +TAL L GH + + L++ KI+ + +G TPL+LA G
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAG 1099
Score = 27.7 bits (60), Expect = 8.5
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 4/93 (4%)
Query: 7 NDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRG-RTGLHLAAARGNVDICQLLH 65
++S PL++A G + L+ G + N + T + LA A G++ + +LL
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLL 655
Query: 66 KFGADLLATDYQGNTALHLC---GHVDTIQFLV 95
GAD G+T L GH + + +L+
Sbjct: 656 AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 62.4 bits (150), Expect = 3e-10
Identities = 50/170 (29%), Positives = 85/170 (50%), Gaps = 26/170 (15%)
Query: 15 PLLQACIDGDFNYSKRLLESGFD---PNIRDSRGRTGLHLAAARGNVDICQLLHKFGADL 71
PL++A G + LL+ G D P + SR T L +AA +G+ C+LL GA +
Sbjct: 1260 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD-TALTIAADKGHYKFCELLIHRGAHI 1318
Query: 72 LATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG--------- 119
+ +GNT L L GH D +Q LV G +D +++ TPL+ A R+G
Sbjct: 1319 DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Query: 120 --VNK-----DVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESH 162
VN+ + +R + ++ ++E+ + H +ET+ A+ + A E++
Sbjct: 1379 KEVNQFPSDIECMRYIATITDKELL---KKCHQCVETIVKAKDQQAAEAN 1425
Score = 54.3 bits (129), Expect = 8e-08
Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 11/141 (7%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA--DLLA 73
L AC G + + LLE+G D + T L A G+V++ +LL GA ++ A
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 435
Query: 74 TDYQGNTALHLCG-HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLE 132
++ L CG HV+ L+ G ++ N +G TPL+ A R G + V LL
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL---- 491
Query: 133 EQEVKGFNRGTHSKLETMQTA 153
+G N ++ ET +TA
Sbjct: 492 ---AQGANINAQTE-ETQETA 508
Score = 52.4 bits (124), Expect = 3e-07
Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 3/119 (2%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL++A +G K LL SG + + + G T L A G+ D+ +L + GADL
Sbjct: 536 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Query: 73 ATDYQGNTAL---HLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
G T L GH+ T+QFL+S G ++ +V G + V+ LL
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELL 654
Score = 51.6 bits (122), Expect = 5e-07
Identities = 49/153 (32%), Positives = 74/153 (48%), Gaps = 15/153 (9%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL+ A G + K LL D N + + G T L A A G VDI ++L GA++
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH 334
Query: 75 DYQGNTAL---HLCGHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRGVNKDVIR-LLE 129
+ G+T L GHV+ + L+ +G I+ N + L LA +G + D++R LLE
Sbjct: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG-HLDMVRFLLE 393
Query: 130 SLEEQEVKGFNRGTHSKLETMQTAESESAMESH 162
+ +QE K + M TA E+ M+ H
Sbjct: 394 AGADQE---------HKTDEMHTALMEACMDGH 417
Score = 48.5 bits (114), Expect = 5e-06
Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 38/150 (25%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAA-------------------RG 56
L +AC DGD N ++LL+ G N G + L LA + RG
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 57 N---------------VDICQLLHKFGADLLATDYQGNTAL-HLC--GHVDTIQFLVSNG 98
N +DI +LL AD+ + GNTAL + C G VD ++ L++ G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 99 LKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
I+ N G TPL+ A G + +V R+L
Sbjct: 329 ANIEDHNENGHTPLMEAASAG-HVEVARVL 357
Score = 47.8 bits (112), Expect = 8e-06
Identities = 29/97 (29%), Positives = 52/97 (53%), Gaps = 3/97 (3%)
Query: 9 SSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFG 68
+ + + L++AC+DG ++ LL+SG N+ + L LAA G+V++ LL + G
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
Query: 69 ADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKID 102
A+L + +G T L GH + + L++ G I+
Sbjct: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Score = 47.4 bits (111), Expect = 1e-05
Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 3/89 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S + L A G + + + L+ G ++R+ +G T L LA+ G+ D+ QLL + GA
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 70 DLLATDYQGNTALHLC---GHVDTIQFLV 95
D+ A D + T L GHV +Q+LV
Sbjct: 1350 DVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 43.9 bits (102), Expect = 1e-04
Identities = 38/128 (29%), Positives = 62/128 (48%), Gaps = 6/128 (4%)
Query: 6 VNDSSQT-NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN S T N L AC G + K LL G + + G T L AA+ G+V++ ++L
Sbjct: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 357
Query: 65 --HKFGADLLATDYQGNTALHLC--GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGV 120
H G + + +++ + C GH+D ++FL+ G + + T L+ A G
Sbjct: 358 LDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG- 416
Query: 121 NKDVIRLL 128
+ +V RLL
Sbjct: 417 HVEVARLL 424
Score = 37.7 bits (86), Expect = 0.008
Identities = 41/142 (28%), Positives = 59/142 (41%), Gaps = 9/142 (6%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S + L AC G L+ RD +G T L LAA G+V + ++L G
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
Query: 70 DLLA-TDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVI 125
D+ A ++ +T L L G + + L++ G + N TPL LA G +
Sbjct: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172
Query: 126 RLLESLEEQEVKGFNRGTHSKL 147
LL + E N T SKL
Sbjct: 1173 ILLNAGAE-----INSRTGSKL 1189
Score = 35.0 bits (79), Expect = 0.053
Identities = 38/121 (31%), Positives = 56/121 (46%), Gaps = 9/121 (7%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLA- 73
PL A G + L+E G + + G T L AA G+ ++ LL GA++ A
Sbjct: 441 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
Query: 74 TDYQGNTALHLC---GHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRGVNKDVIRLLE 129
T+ TAL L G + FL+ G I++ C +TPL+ A + G + V LL
Sbjct: 501 TEETQETALTLACCGGFSEVADFLIKAGADIELGC----STPLMEASQEGHLELVKYLLA 556
Query: 130 S 130
S
Sbjct: 557 S 557
Score = 34.3 bits (77), Expect = 0.090
Identities = 50/193 (25%), Positives = 75/193 (38%), Gaps = 10/193 (5%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL AC G LL G + R+ T L LAA+ G V+I ++L GA++
Sbjct: 1123 DTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEIN 1182
Query: 73 AT--DYQGNTALHLC---GHVDTIQFLVSNGLKIDI-CNHQGATPLVLAKRRGVNKDVIR 126
+ G + L L GHV ++ L+ G I+ T L LA +G + V
Sbjct: 1183 SRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSL 1242
Query: 127 LLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFRTTWQEF 186
LL+ E +R M+ A A LL+ + S R T
Sbjct: 1243 LLDRKANVE----HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
Query: 187 VEDLGFWRVLLLI 199
D G ++ L+
Sbjct: 1299 AADKGHYKFCELL 1311
Score = 31.6 bits (70), Expect = 0.59
Identities = 19/54 (35%), Positives = 29/54 (53%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHK 66
N PL A G F+ + L+++G D + D+R T L A +G+V + Q L K
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 30.0 bits (66), Expect = 1.7
Identities = 17/49 (34%), Positives = 27/49 (55%), Gaps = 3/49 (6%)
Query: 74 TDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
T+ +TAL L GH + + L++ KI+ + +G TPL+LA G
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAG 1099
Score = 27.7 bits (60), Expect = 8.5
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 4/93 (4%)
Query: 7 NDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRG-RTGLHLAAARGNVDICQLLH 65
++S PL++A G + L+ G + N + T + LA A G++ + +LL
Sbjct: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLL 655
Query: 66 KFGADLLATDYQGNTALHLC---GHVDTIQFLV 95
GAD G+T L GH + + +L+
Sbjct: 656 AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 62.0 bits (149), Expect = 4e-10
Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 7/165 (4%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G +K LL+ G PN R G T LH+A + +V + +LL K GA + A
Sbjct: 374 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 433
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ GH+ ++ L+ G ++ N + TPL +A R G + LL++
Sbjct: 434 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493
Query: 132 EEQEVKGFNRGT--HSKLETMQTAESESAMESHSLLNPNLQQGEG 174
+ K + T H T + +E+++ NPNL G
Sbjct: 494 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA--NPNLATTAG 536
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/124 (34%), Positives = 66/124 (53%), Gaps = 5/124 (4%)
Query: 17 LQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVD-ICQLLHKFGADLLATD 75
L+A G+ + + L +G D N + G GLHLA+ G+V + +LLHK L T
Sbjct: 50 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 108
Query: 76 YQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLE 132
+GNTALH L G + ++ LV+ G ++ + +G TPL +A + + V LLE+
Sbjct: 109 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 168
Query: 133 EQEV 136
Q V
Sbjct: 169 NQNV 172
Score = 53.5 bits (127), Expect = 1e-07
Identities = 27/88 (30%), Positives = 49/88 (55%), Gaps = 3/88 (3%)
Query: 44 RGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLK 100
+G T LH+AA G ++ + L +GA++ A +G T L++ H++ ++FL+ NG
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 169
Query: 101 IDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ G TPL +A ++G V L+
Sbjct: 170 QNVATEDGFTPLAVALQQGHENVVAHLI 197
Score = 52.8 bits (125), Expect = 2e-07
Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 3/126 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A ++ LL+ G N +G T LHLAA G+ ++ LL A+
Sbjct: 638 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LHL GHV L+ +G+ +D G TPL +A G K V LL+
Sbjct: 698 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 757
Query: 132 EEQEVK 137
+ K
Sbjct: 758 ADVNAK 763
Score = 52.4 bits (124), Expect = 3e-07
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 4/124 (3%)
Query: 8 DSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKF 67
+S Q PL A +G LL + N+ + G T LHL A G+V + +L K
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 68 GADLLATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
G + AT G T LH+ H + ++FL+ + ++ G +PL A ++G + D+
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG-HTDI 782
Query: 125 IRLL 128
+ LL
Sbjct: 783 VTLL 786
Score = 50.8 bits (120), Expect = 9e-07
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL +G + L++ G + G T LH+A+ GN+ + + L + AD+ A
Sbjct: 704 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 763
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
G + LH GH D + L+ NG + + G TPL +AKR G
Sbjct: 764 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 811
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/117 (32%), Positives = 55/117 (47%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + N ++ LL G N G T LH+A+ RGNV + +LL GA +
Sbjct: 242 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 301
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
T LH GHV + L+ +G I G +P+ +A +G + D +RLL
Sbjct: 302 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA-AQGDHLDCVRLL 357
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/117 (31%), Positives = 54/117 (46%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G N K LLE+ +PN+ + G T LH+AA G+V+ L + A
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
+G T LH+ G V + L+ + G TPL +A N D+++LL
Sbjct: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLL 621
Score = 49.7 bits (117), Expect = 2e-06
Identities = 31/92 (33%), Positives = 48/92 (52%), Gaps = 3/92 (3%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LL++ +P++ G T LH+AA N+++ QLL GA + T G T LH+ G+
Sbjct: 225 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 284
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
V ++ L+ G +I+ TPL A R G
Sbjct: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNG 316
Score = 49.3 bits (116), Expect = 3e-06
Identities = 44/145 (30%), Positives = 65/145 (44%), Gaps = 8/145 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G ++ LLE PN G T LH+A N+DI +LL G +
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 631
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LH+ V+ + L+ G + + QG TPL LA + G + +++ LL S
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLS- 689
Query: 132 EEQEVKGFNRGTHSKLETMQTAESE 156
++ G N G S L + E
Sbjct: 690 --KQANG-NLGNKSGLTPLHLVAQE 711
Score = 45.4 bits (106), Expect = 4e-05
Identities = 42/160 (26%), Positives = 71/160 (44%), Gaps = 8/160 (5%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G +K LL++ N + +T LH AA G+ ++ +LL + A+
Sbjct: 469 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
G+T LH+ GHV+T+ L+ +G TPL +A + G +R+
Sbjct: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG----KVRV 584
Query: 128 LESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNP 167
E L E++ N + L + A + ++ LL P
Sbjct: 585 AELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLP 623
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 34/156 (21%)
Query: 6 VNDSSQTN-VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN SQ PL A + K LLE+G + N+ G T L +A +G+ ++ L
Sbjct: 137 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 196
Query: 65 HKFG----------------------ADLLATD-------YQGNTALHLCGHVDTI---Q 92
+G A LL D G T LH+ H + + Q
Sbjct: 197 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 256
Query: 93 FLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
L++ G ++ G TPL +A RRG N ++RLL
Sbjct: 257 LLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 291
Score = 43.1 bits (100), Expect = 2e-04
Identities = 34/120 (28%), Positives = 57/120 (47%), Gaps = 7/120 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A +G S+ LL+ G + G + +H+AA ++D +LL ++ A++
Sbjct: 308 PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 367
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
T LH+ CGH + L+ G K + G TPL +A K+ +R++E L
Sbjct: 368 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA----CKKNHVRVMELL 423
Score = 42.4 bits (98), Expect = 3e-04
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 4/139 (2%)
Query: 6 VNDSSQTNV-PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN + Q + PL A G+ + LL+ G + T LH AA G+V I ++L
Sbjct: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
Query: 65 HKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVN 121
GA + A G + +H+ H+D ++ L+ +ID TPL +A G +
Sbjct: 325 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 384
Query: 122 KDVIRLLESLEEQEVKGFN 140
+ LL+ + + N
Sbjct: 385 RVAKVLLDKGAKPNSRALN 403
Score = 38.9 bits (89), Expect = 0.004
Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 6/132 (4%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL A +G LLE +G T LH+AA G V + +LL + A
Sbjct: 537 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
Query: 73 ATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG---VNKDVIR 126
A G T LH+ H +D ++ L+ G G TPL +A ++ V + +++
Sbjct: 597 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 656
Query: 127 LLESLEEQEVKG 138
S + V+G
Sbjct: 657 YGGSANAESVQG 668
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 62.0 bits (149), Expect = 4e-10
Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 7/165 (4%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G +K LL+ G PN R G T LH+A + +V + +LL K GA + A
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ GH+ ++ L+ G ++ N + TPL +A R G + LL++
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 132 EEQEVKGFNRGT--HSKLETMQTAESESAMESHSLLNPNLQQGEG 174
+ K + T H T + +E+++ NPNL G
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA--NPNLATTAG 503
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/124 (34%), Positives = 66/124 (53%), Gaps = 5/124 (4%)
Query: 17 LQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVD-ICQLLHKFGADLLATD 75
L+A G+ + + L +G D N + G GLHLA+ G+V + +LLHK L T
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75
Query: 76 YQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLE 132
+GNTALH L G + ++ LV+ G ++ + +G TPL +A + + V LLE+
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 133 EQEV 136
Q V
Sbjct: 136 NQNV 139
Score = 53.5 bits (127), Expect = 1e-07
Identities = 27/88 (30%), Positives = 49/88 (55%), Gaps = 3/88 (3%)
Query: 44 RGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLK 100
+G T LH+AA G ++ + L +GA++ A +G T L++ H++ ++FL+ NG
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 101 IDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ G TPL +A ++G V L+
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLI 164
Score = 52.8 bits (125), Expect = 2e-07
Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 3/126 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A ++ LL+ G N +G T LHLAA G+ ++ LL A+
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LHL GHV L+ +G+ +D G TPL +A G K V LL+
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 132 EEQEVK 137
+ K
Sbjct: 725 ADVNAK 730
Score = 52.4 bits (124), Expect = 3e-07
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 4/124 (3%)
Query: 8 DSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKF 67
+S Q PL A +G LL + N+ + G T LHL A G+V + +L K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 68 GADLLATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
G + AT G T LH+ H + ++FL+ + ++ G +PL A ++G + D+
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG-HTDI 749
Query: 125 IRLL 128
+ LL
Sbjct: 750 VTLL 753
Score = 50.8 bits (120), Expect = 9e-07
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL +G + L++ G + G T LH+A+ GN+ + + L + AD+ A
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
G + LH GH D + L+ NG + + G TPL +AKR G
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/117 (32%), Positives = 55/117 (47%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + N ++ LL G N G T LH+A+ RGNV + +LL GA +
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
T LH GHV + L+ +G I G +P+ +A +G + D +RLL
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA-AQGDHLDCVRLL 324
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/117 (31%), Positives = 54/117 (46%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G N K LLE+ +PN+ + G T LH+AA G+V+ L + A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
+G T LH+ G V + L+ + G TPL +A N D+++LL
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLL 588
Score = 49.7 bits (117), Expect = 2e-06
Identities = 31/92 (33%), Positives = 48/92 (52%), Gaps = 3/92 (3%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LL++ +P++ G T LH+AA N+++ QLL GA + T G T LH+ G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
V ++ L+ G +I+ TPL A R G
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283
Score = 49.3 bits (116), Expect = 3e-06
Identities = 44/145 (30%), Positives = 65/145 (44%), Gaps = 8/145 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G ++ LLE PN G T LH+A N+DI +LL G +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LH+ V+ + L+ G + + QG TPL LA + G + +++ LL S
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLS- 656
Query: 132 EEQEVKGFNRGTHSKLETMQTAESE 156
++ G N G S L + E
Sbjct: 657 --KQANG-NLGNKSGLTPLHLVAQE 678
Score = 45.4 bits (106), Expect = 4e-05
Identities = 42/160 (26%), Positives = 71/160 (44%), Gaps = 8/160 (5%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G +K LL++ N + +T LH AA G+ ++ +LL + A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
G+T LH+ GHV+T+ L+ +G TPL +A + G +R+
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG----KVRV 551
Query: 128 LESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNP 167
E L E++ N + L + A + ++ LL P
Sbjct: 552 AELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 34/156 (21%)
Query: 6 VNDSSQTN-VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN SQ PL A + K LLE+G + N+ G T L +A +G+ ++ L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 65 HKFG----------------------ADLLATD-------YQGNTALHLCGHVDTI---Q 92
+G A LL D G T LH+ H + + Q
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 93 FLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
L++ G ++ G TPL +A RRG N ++RLL
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
Score = 43.1 bits (100), Expect = 2e-04
Identities = 34/120 (28%), Positives = 57/120 (47%), Gaps = 7/120 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A +G S+ LL+ G + G + +H+AA ++D +LL ++ A++
Sbjct: 275 PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
T LH+ CGH + L+ G K + G TPL +A K+ +R++E L
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA----CKKNHVRVMELL 390
Score = 42.4 bits (98), Expect = 3e-04
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 4/139 (2%)
Query: 6 VNDSSQTNV-PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN + Q + PL A G+ + LL+ G + T LH AA G+V I ++L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 65 HKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVN 121
GA + A G + +H+ H+D ++ L+ +ID TPL +A G +
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
Query: 122 KDVIRLLESLEEQEVKGFN 140
+ LL+ + + N
Sbjct: 352 RVAKVLLDKGAKPNSRALN 370
Score = 38.9 bits (89), Expect = 0.004
Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 6/132 (4%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL A +G LLE +G T LH+AA G V + +LL + A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 73 ATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG---VNKDVIR 126
A G T LH+ H +D ++ L+ G G TPL +A ++ V + +++
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 127 LLESLEEQEVKG 138
S + V+G
Sbjct: 624 YGGSANAESVQG 635
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 62.0 bits (149), Expect = 4e-10
Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 7/165 (4%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G +K LL+ G PN R G T LH+A + +V + +LL K GA + A
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ GH+ ++ L+ G ++ N + TPL +A R G + LL++
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 132 EEQEVKGFNRGT--HSKLETMQTAESESAMESHSLLNPNLQQGEG 174
+ K + T H T + +E+++ NPNL G
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA--NPNLATTAG 503
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/124 (34%), Positives = 66/124 (53%), Gaps = 5/124 (4%)
Query: 17 LQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVD-ICQLLHKFGADLLATD 75
L+A G+ + + L +G D N + G GLHLA+ G+V + +LLHK L T
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75
Query: 76 YQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLE 132
+GNTALH L G + ++ LV+ G ++ + +G TPL +A + + V LLE+
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 133 EQEV 136
Q V
Sbjct: 136 NQNV 139
Score = 53.5 bits (127), Expect = 1e-07
Identities = 27/88 (30%), Positives = 49/88 (55%), Gaps = 3/88 (3%)
Query: 44 RGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLK 100
+G T LH+AA G ++ + L +GA++ A +G T L++ H++ ++FL+ NG
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 101 IDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ G TPL +A ++G V L+
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLI 164
Score = 52.8 bits (125), Expect = 2e-07
Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 3/126 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A ++ LL+ G N +G T LHLAA G+ ++ LL A+
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LHL GHV L+ +G+ +D G TPL +A G K V LL+
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 132 EEQEVK 137
+ K
Sbjct: 725 ADVNAK 730
Score = 52.4 bits (124), Expect = 3e-07
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 4/124 (3%)
Query: 8 DSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKF 67
+S Q PL A +G LL + N+ + G T LHL A G+V + +L K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 68 GADLLATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
G + AT G T LH+ H + ++FL+ + ++ G +PL A ++G + D+
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG-HTDI 749
Query: 125 IRLL 128
+ LL
Sbjct: 750 VTLL 753
Score = 50.8 bits (120), Expect = 9e-07
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL +G + L++ G + G T LH+A+ GN+ + + L + AD+ A
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
G + LH GH D + L+ NG + + G TPL +AKR G
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/117 (32%), Positives = 55/117 (47%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + N ++ LL G N G T LH+A+ RGNV + +LL GA +
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
T LH GHV + L+ +G I G +P+ +A +G + D +RLL
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA-AQGDHLDCVRLL 324
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/117 (31%), Positives = 54/117 (46%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G N K LLE+ +PN+ + G T LH+AA G+V+ L + A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
+G T LH+ G V + L+ + G TPL +A N D+++LL
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLL 588
Score = 49.7 bits (117), Expect = 2e-06
Identities = 31/92 (33%), Positives = 48/92 (52%), Gaps = 3/92 (3%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LL++ +P++ G T LH+AA N+++ QLL GA + T G T LH+ G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
V ++ L+ G +I+ TPL A R G
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283
Score = 49.3 bits (116), Expect = 3e-06
Identities = 44/145 (30%), Positives = 65/145 (44%), Gaps = 8/145 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G ++ LLE PN G T LH+A N+DI +LL G +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LH+ V+ + L+ G + + QG TPL LA + G + +++ LL S
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLS- 656
Query: 132 EEQEVKGFNRGTHSKLETMQTAESE 156
++ G N G S L + E
Sbjct: 657 --KQANG-NLGNKSGLTPLHLVAQE 678
Score = 45.4 bits (106), Expect = 4e-05
Identities = 42/160 (26%), Positives = 71/160 (44%), Gaps = 8/160 (5%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G +K LL++ N + +T LH AA G+ ++ +LL + A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
G+T LH+ GHV+T+ L+ +G TPL +A + G +R+
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG----KVRV 551
Query: 128 LESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNP 167
E L E++ N + L + A + ++ LL P
Sbjct: 552 AELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 34/156 (21%)
Query: 6 VNDSSQTN-VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN SQ PL A + K LLE+G + N+ G T L +A +G+ ++ L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 65 HKFG----------------------ADLLATD-------YQGNTALHLCGHVDTI---Q 92
+G A LL D G T LH+ H + + Q
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 93 FLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
L++ G ++ G TPL +A RRG N ++RLL
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
Score = 43.1 bits (100), Expect = 2e-04
Identities = 34/120 (28%), Positives = 57/120 (47%), Gaps = 7/120 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A +G S+ LL+ G + G + +H+AA ++D +LL ++ A++
Sbjct: 275 PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
T LH+ CGH + L+ G K + G TPL +A K+ +R++E L
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA----CKKNHVRVMELL 390
Score = 42.4 bits (98), Expect = 3e-04
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 4/139 (2%)
Query: 6 VNDSSQTNV-PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN + Q + PL A G+ + LL+ G + T LH AA G+V I ++L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 65 HKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVN 121
GA + A G + +H+ H+D ++ L+ +ID TPL +A G +
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
Query: 122 KDVIRLLESLEEQEVKGFN 140
+ LL+ + + N
Sbjct: 352 RVAKVLLDKGAKPNSRALN 370
Score = 38.9 bits (89), Expect = 0.004
Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 6/132 (4%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL A +G LLE +G T LH+AA G V + +LL + A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 73 ATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG---VNKDVIR 126
A G T LH+ H +D ++ L+ G G TPL +A ++ V + +++
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 127 LLESLEEQEVKG 138
S + V+G
Sbjct: 624 YGGSANAESVQG 635
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 62.0 bits (149), Expect = 4e-10
Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 7/165 (4%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G +K LL+ G PN R G T LH+A + +V + +LL K GA + A
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ GH+ ++ L+ G ++ N + TPL +A R G + LL++
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 132 EEQEVKGFNRGT--HSKLETMQTAESESAMESHSLLNPNLQQGEG 174
+ K + T H T + +E+++ NPNL G
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA--NPNLATTAG 503
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/124 (34%), Positives = 66/124 (53%), Gaps = 5/124 (4%)
Query: 17 LQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVD-ICQLLHKFGADLLATD 75
L+A G+ + + L +G D N + G GLHLA+ G+V + +LLHK L T
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75
Query: 76 YQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLE 132
+GNTALH L G + ++ LV+ G ++ + +G TPL +A + + V LLE+
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 133 EQEV 136
Q V
Sbjct: 136 NQNV 139
Score = 53.5 bits (127), Expect = 1e-07
Identities = 27/88 (30%), Positives = 49/88 (55%), Gaps = 3/88 (3%)
Query: 44 RGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLK 100
+G T LH+AA G ++ + L +GA++ A +G T L++ H++ ++FL+ NG
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 101 IDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ G TPL +A ++G V L+
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLI 164
Score = 52.8 bits (125), Expect = 2e-07
Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 3/126 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A ++ LL+ G N +G T LHLAA G+ ++ LL A+
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LHL GHV L+ +G+ +D G TPL +A G K V LL+
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 132 EEQEVK 137
+ K
Sbjct: 725 ADVNAK 730
Score = 52.4 bits (124), Expect = 3e-07
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 4/124 (3%)
Query: 8 DSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKF 67
+S Q PL A +G LL + N+ + G T LHL A G+V + +L K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 68 GADLLATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
G + AT G T LH+ H + ++FL+ + ++ G +PL A ++G + D+
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG-HTDI 749
Query: 125 IRLL 128
+ LL
Sbjct: 750 VTLL 753
Score = 50.8 bits (120), Expect = 9e-07
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL +G + L++ G + G T LH+A+ GN+ + + L + AD+ A
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
G + LH GH D + L+ NG + + G TPL +AKR G
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/117 (32%), Positives = 55/117 (47%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + N ++ LL G N G T LH+A+ RGNV + +LL GA +
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
T LH GHV + L+ +G I G +P+ +A +G + D +RLL
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA-AQGDHLDCVRLL 324
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/117 (31%), Positives = 54/117 (46%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G N K LLE+ +PN+ + G T LH+AA G+V+ L + A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
+G T LH+ G V + L+ + G TPL +A N D+++LL
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLL 588
Score = 49.7 bits (117), Expect = 2e-06
Identities = 31/92 (33%), Positives = 48/92 (52%), Gaps = 3/92 (3%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LL++ +P++ G T LH+AA N+++ QLL GA + T G T LH+ G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
V ++ L+ G +I+ TPL A R G
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283
Score = 49.3 bits (116), Expect = 3e-06
Identities = 44/145 (30%), Positives = 65/145 (44%), Gaps = 8/145 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G ++ LLE PN G T LH+A N+DI +LL G +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LH+ V+ + L+ G + + QG TPL LA + G + +++ LL S
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLS- 656
Query: 132 EEQEVKGFNRGTHSKLETMQTAESE 156
++ G N G S L + E
Sbjct: 657 --KQANG-NLGNKSGLTPLHLVAQE 678
Score = 45.4 bits (106), Expect = 4e-05
Identities = 42/160 (26%), Positives = 71/160 (44%), Gaps = 8/160 (5%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G +K LL++ N + +T LH AA G+ ++ +LL + A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
G+T LH+ GHV+T+ L+ +G TPL +A + G +R+
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG----KVRV 551
Query: 128 LESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNP 167
E L E++ N + L + A + ++ LL P
Sbjct: 552 AELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 34/156 (21%)
Query: 6 VNDSSQTN-VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN SQ PL A + K LLE+G + N+ G T L +A +G+ ++ L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 65 HKFG----------------------ADLLATD-------YQGNTALHLCGHVDTI---Q 92
+G A LL D G T LH+ H + + Q
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 93 FLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
L++ G ++ G TPL +A RRG N ++RLL
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
Score = 43.1 bits (100), Expect = 2e-04
Identities = 34/120 (28%), Positives = 57/120 (47%), Gaps = 7/120 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A +G S+ LL+ G + G + +H+AA ++D +LL ++ A++
Sbjct: 275 PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
T LH+ CGH + L+ G K + G TPL +A K+ +R++E L
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA----CKKNHVRVMELL 390
Score = 42.4 bits (98), Expect = 3e-04
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 4/139 (2%)
Query: 6 VNDSSQTNV-PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN + Q + PL A G+ + LL+ G + T LH AA G+V I ++L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 65 HKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVN 121
GA + A G + +H+ H+D ++ L+ +ID TPL +A G +
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
Query: 122 KDVIRLLESLEEQEVKGFN 140
+ LL+ + + N
Sbjct: 352 RVAKVLLDKGAKPNSRALN 370
Score = 38.9 bits (89), Expect = 0.004
Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 6/132 (4%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL A +G LLE +G T LH+AA G V + +LL + A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 73 ATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG---VNKDVIR 126
A G T LH+ H +D ++ L+ G G TPL +A ++ V + +++
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 127 LLESLEEQEVKG 138
S + V+G
Sbjct: 624 YGGSANAESVQG 635
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 62.0 bits (149), Expect = 4e-10
Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 7/165 (4%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G +K LL+ G PN R G T LH+A + +V + +LL K GA + A
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
G T LH+ GH+ ++ L+ G ++ N + TPL +A R G + LL++
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 132 EEQEVKGFNRGT--HSKLETMQTAESESAMESHSLLNPNLQQGEG 174
+ K + T H T + +E+++ NPNL G
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA--NPNLATTAG 503
Score = 57.4 bits (137), Expect = 1e-08
Identities = 43/124 (34%), Positives = 66/124 (53%), Gaps = 5/124 (4%)
Query: 17 LQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVD-ICQLLHKFGADLLATD 75
L+A G+ + + L +G D N + G GLHLA+ G+V + +LLHK L T
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75
Query: 76 YQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLE 132
+GNTALH L G + ++ LV+ G ++ + +G TPL +A + + V LLE+
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 133 EQEV 136
Q V
Sbjct: 136 NQNV 139
Score = 53.5 bits (127), Expect = 1e-07
Identities = 27/88 (30%), Positives = 49/88 (55%), Gaps = 3/88 (3%)
Query: 44 RGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLK 100
+G T LH+AA G ++ + L +GA++ A +G T L++ H++ ++FL+ NG
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 101 IDICNHQGATPLVLAKRRGVNKDVIRLL 128
++ G TPL +A ++G V L+
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLI 164
Score = 52.8 bits (125), Expect = 2e-07
Identities = 40/126 (31%), Positives = 56/126 (44%), Gaps = 3/126 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A ++ LL+ G N +G T LHLAA G+ ++ LL A+
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LHL GHV L+ +G+ +D G TPL +A G K V LL+
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 132 EEQEVK 137
+ K
Sbjct: 725 ADVNAK 730
Score = 52.4 bits (124), Expect = 3e-07
Identities = 37/124 (29%), Positives = 60/124 (48%), Gaps = 4/124 (3%)
Query: 8 DSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKF 67
+S Q PL A +G LL + N+ + G T LHL A G+V + +L K
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 68 GADLLATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
G + AT G T LH+ H + ++FL+ + ++ G +PL A ++G + D+
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQG-HTDI 749
Query: 125 IRLL 128
+ LL
Sbjct: 750 VTLL 753
Score = 50.8 bits (120), Expect = 9e-07
Identities = 33/108 (30%), Positives = 51/108 (47%), Gaps = 3/108 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL +G + L++ G + G T LH+A+ GN+ + + L + AD+ A
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
G + LH GH D + L+ NG + + G TPL +AKR G
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLG 778
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/117 (32%), Positives = 55/117 (47%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A + N ++ LL G N G T LH+A+ RGNV + +LL GA +
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
T LH GHV + L+ +G I G +P+ +A +G + D +RLL
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA-AQGDHLDCVRLL 324
Score = 50.1 bits (118), Expect = 2e-06
Identities = 37/117 (31%), Positives = 54/117 (46%), Gaps = 4/117 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G N K LLE+ +PN+ + G T LH+AA G+V+ L + A
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
+G T LH+ G V + L+ + G TPL +A N D+++LL
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN-NLDIVKLL 588
Score = 49.7 bits (117), Expect = 2e-06
Identities = 31/92 (33%), Positives = 48/92 (52%), Gaps = 3/92 (3%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GH 87
LL++ +P++ G T LH+AA N+++ QLL GA + T G T LH+ G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
V ++ L+ G +I+ TPL A R G
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNG 283
Score = 49.3 bits (116), Expect = 3e-06
Identities = 44/145 (30%), Positives = 65/145 (44%), Gaps = 8/145 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A G ++ LLE PN G T LH+A N+DI +LL G +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
+ G T LH+ V+ + L+ G + + QG TPL LA + G + +++ LL S
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLS- 656
Query: 132 EEQEVKGFNRGTHSKLETMQTAESE 156
++ G N G S L + E
Sbjct: 657 --KQANG-NLGNKSGLTPLHLVAQE 678
Score = 45.4 bits (106), Expect = 4e-05
Identities = 42/160 (26%), Positives = 71/160 (44%), Gaps = 8/160 (5%)
Query: 11 QTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGAD 70
+ PL A G +K LL++ N + +T LH AA G+ ++ +LL + A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 71 LLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRL 127
G+T LH+ GHV+T+ L+ +G TPL +A + G +R+
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG----KVRV 551
Query: 128 LESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNP 167
E L E++ N + L + A + ++ LL P
Sbjct: 552 AELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 34/156 (21%)
Query: 6 VNDSSQTN-VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN SQ PL A + K LLE+G + N+ G T L +A +G+ ++ L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 65 HKFG----------------------ADLLATD-------YQGNTALHLCGHVDTI---Q 92
+G A LL D G T LH+ H + + Q
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 93 FLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
L++ G ++ G TPL +A RRG N ++RLL
Sbjct: 224 LLLNRGASVNFTPQNGITPLHIASRRG-NVIMVRLL 258
Score = 43.1 bits (100), Expect = 2e-04
Identities = 34/120 (28%), Positives = 57/120 (47%), Gaps = 7/120 (5%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A +G S+ LL+ G + G + +H+AA ++D +LL ++ A++
Sbjct: 275 PLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDI 334
Query: 75 DYQGNTALHL---CGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131
T LH+ CGH + L+ G K + G TPL +A K+ +R++E L
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA----CKKNHVRVMELL 390
Score = 42.4 bits (98), Expect = 3e-04
Identities = 37/139 (26%), Positives = 61/139 (43%), Gaps = 4/139 (2%)
Query: 6 VNDSSQTNV-PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLL 64
VN + Q + PL A G+ + LL+ G + T LH AA G+V I ++L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 65 HKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVN 121
GA + A G + +H+ H+D ++ L+ +ID TPL +A G +
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
Query: 122 KDVIRLLESLEEQEVKGFN 140
+ LL+ + + N
Sbjct: 352 RVAKVLLDKGAKPNSRALN 370
Score = 38.9 bits (89), Expect = 0.004
Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 6/132 (4%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLL 72
+ PL A +G LLE +G T LH+AA G V + +LL + A
Sbjct: 504 HTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 73 ATDYQGNTALHLCGH---VDTIQFLVSNGLKIDICNHQGATPLVLAKRRG---VNKDVIR 126
A G T LH+ H +D ++ L+ G G TPL +A ++ V + +++
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 127 LLESLEEQEVKG 138
S + V+G
Sbjct: 624 YGGSANAESVQG 635
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 62.0 bits (149), Expect = 4e-10
Identities = 42/118 (35%), Positives = 59/118 (50%), Gaps = 4/118 (3%)
Query: 14 VPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLA 73
VPL G + LL G D N+ D +GRT L +AA+ G++ L GA +
Sbjct: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128
Query: 74 TDYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
D +G TAL L GH+ ++ LV NG D + G TPL LA G + +V++ L
Sbjct: 1129 MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYG-DAEVVQFL 1185
Score = 48.5 bits (114), Expect = 5e-06
Identities = 39/124 (31%), Positives = 55/124 (44%), Gaps = 4/124 (3%)
Query: 8 DSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKF 67
DS L A G + LLE G + RG L +G+ I LL
Sbjct: 1030 DSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTH 1089
Query: 68 GADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDV 124
GAD+ D QG T L + GH+ T+ FL++ G I + + +G T L A +G + V
Sbjct: 1090 GADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKG-HLSV 1148
Query: 125 IRLL 128
+R L
Sbjct: 1149 VRSL 1152
Score = 43.9 bits (102), Expect = 1e-04
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 19 ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQG 78
AC+ G + + L+++G + D GRT L LAA G+ ++ Q L GA + DY G
Sbjct: 1140 ACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSG 1199
Query: 79 NTALHL---CGHVDTIQFLVSNGLKI 101
L C + + L+ G KI
Sbjct: 1200 MRPLDRAVGCRNTSVVVTLLKKGAKI 1225
Score = 37.7 bits (86), Expect = 0.008
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 8/89 (8%)
Query: 13 NVPLLQACIDGDFNYSKR---LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
N P+L C+ Y++ LLE G + + G T L AAA G + I LL K A
Sbjct: 885 NAPIL--CVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRA 942
Query: 70 DLLATDYQGNTAL---HLCGHVDTIQFLV 95
+ D G AL L GH++ ++FL+
Sbjct: 943 KVDHLDKNGQCALVHAALRGHLEVVKFLI 971
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 61.2 bits (147), Expect = 7e-10
Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 3/112 (2%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A ++ + ++LL SGF+ + D GRT LH AAA GNV+ +LL GAD
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 75 DYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKD 123
D G T LH H I+ LV+ G ++ + G T L A ++++
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRN 461
Score = 61.2 bits (147), Expect = 7e-10
Identities = 44/138 (31%), Positives = 71/138 (51%), Gaps = 6/138 (4%)
Query: 4 VFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDP---NIRDSRGRTGLHLAAARGNVDI 60
+FV D+ PL + I+G + LLE +P +++D++G+T L LA A G++D
Sbjct: 601 IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660
Query: 61 CQLLHKFGADLLATDYQGNTALH---LCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKR 117
LL + A++ D G TALH + GH + +Q L+ + I + +G TPL A
Sbjct: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAA 720
Query: 118 RGVNKDVIRLLESLEEQE 135
RG + LL+ +E
Sbjct: 721 RGHATWLSELLQMALSEE 738
Score = 58.2 bits (139), Expect = 6e-09
Identities = 37/106 (34%), Positives = 57/106 (53%), Gaps = 6/106 (5%)
Query: 39 NIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALH---LCGHVDTIQFLV 95
N+ D GRT LH AA G+V++ LL GA++ A D + ALH GH+D + L+
Sbjct: 109 NVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI 168
Query: 96 SNGLKIDICNHQGATPLVLAKRRG---VNKDVIRLLESLEEQEVKG 138
++G ++ + +G TPL A G V K ++ L ++E V G
Sbjct: 169 NHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYG 214
Score = 57.0 bits (136), Expect = 1e-08
Identities = 37/117 (31%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 16 LLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATD 75
L A ++G LL G + N D + R LH AA G++D+ LL GA++ D
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
Query: 76 YQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
+G T LH G ++ ++ L++ G++ID N G T L +A G + V L++
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID 235
Score = 57.0 bits (136), Expect = 1e-08
Identities = 45/130 (34%), Positives = 65/130 (50%), Gaps = 7/130 (5%)
Query: 7 NDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHK 66
+DS T PL A +G + LL+S D +IRD +GRT L LAA +G+ + + L
Sbjct: 537 SDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALIN 596
Query: 67 FGADLLATD-YQGNTALH---LCGHVDTIQFLV---SNGLKIDICNHQGATPLVLAKRRG 119
GA + D T LH + GH ++ L+ N +D+ + +G TPL+LA G
Sbjct: 597 PGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYG 656
Query: 120 VNKDVIRLLE 129
V LLE
Sbjct: 657 HIDAVSLLLE 666
Score = 53.9 bits (128), Expect = 1e-07
Identities = 42/137 (30%), Positives = 64/137 (46%), Gaps = 11/137 (8%)
Query: 4 VFVNDSSQTNV-------PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARG 56
+ VN+ + N+ PL + G F S+ L+++G + + D G T LH+AA G
Sbjct: 266 LLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYG 325
Query: 57 NVDICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLV 113
+ + L GAD LHL H D + L+S+G +ID + G T L
Sbjct: 326 HELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLH 385
Query: 114 LAKRRGVNKDVIRLLES 130
A G N + I+LL+S
Sbjct: 386 AAAAGG-NVECIKLLQS 401
Score = 52.8 bits (125), Expect = 2e-07
Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 13 NVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDIC-QLLHKFGADL 71
N L AC +G L++ G + N ++ G T LH AAA + +C +LL GAD+
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 72 LATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
G + LH+ G Q L+ NG +ID + G TPL +A R G
Sbjct: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYG 325
Score = 47.0 bits (110), Expect = 1e-05
Identities = 37/127 (29%), Positives = 59/127 (46%), Gaps = 7/127 (5%)
Query: 17 LQACIDGDFNYSKRLLESGFDPNI---RDSRGRTGLHLAAARGNVDICQLLHKFGADLLA 73
L I D LL D +I RD +GRT L AA +V+ QLL + A + A
Sbjct: 783 LHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNA 842
Query: 74 TDYQGNTALHLC---GHVDTIQFLVSNG-LKIDICNHQGATPLVLAKRRGVNKDVIRLLE 129
D G TAL + G + LV++ + + + TPL LA +G K + +L+
Sbjct: 843 VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
Query: 130 SLEEQEV 136
++++ +
Sbjct: 903 KIQDESL 909
Score = 45.4 bits (106), Expect = 4e-05
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 4/109 (3%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
PL A +G N K LL G + + + G T LH+A G + L +GA++
Sbjct: 184 PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 243
Query: 75 DYQGNTALHLCGHVD----TIQFLVSNGLKIDICNHQGATPLVLAKRRG 119
+ G T LH ++ LV+NG ++I + G +PL + G
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG 292
Score = 41.6 bits (96), Expect = 6e-04
Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 5/103 (4%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNT--ALHLC--- 85
LL++ +P+IRD G +H AAA G+ +LL + G T LHL
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552
Query: 86 GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLL 128
GH ++ L+ + + +DI + +G T L LA +G + V L+
Sbjct: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595
Score = 40.4 bits (93), Expect = 0.001
Identities = 37/123 (30%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALH---LCGH 87
L+ D N DS RT LH+AA G+ +I +LL GA + A D T LH
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 88 VDTIQFLVSNGLKIDICNHQGATPL-VLAKRRGVN--KDVIRLLESLEEQEVKGFNRGTH 144
+ +Q L+ + ++ + TPL V A + V + +I LL S+ + G H
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
Query: 145 SKL 147
+ L
Sbjct: 122 AAL 124
Score = 40.0 bits (92), Expect = 0.002
Identities = 34/122 (27%), Positives = 55/122 (45%), Gaps = 4/122 (3%)
Query: 10 SQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69
S+ PL A GD + L+ SG N +D+ T LH A A + + Q+L K A
Sbjct: 14 SEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSA 73
Query: 70 DLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIR 126
D+ A D T LH+ V + ++ +++ + G T L A G + +++
Sbjct: 74 DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNG-HVEMVN 132
Query: 127 LL 128
LL
Sbjct: 133 LL 134
Score = 31.2 bits (69), Expect = 0.77
Identities = 26/73 (35%), Positives = 32/73 (43%), Gaps = 5/73 (6%)
Query: 15 PLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGN---VDICQLLHKFGADL 71
PL A + LL N D+ G+T L +AA G VDI L++ ADL
Sbjct: 817 PLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDI--LVNSAQADL 874
Query: 72 LATDYQGNTALHL 84
D NT LHL
Sbjct: 875 TVKDKDLNTPLHL 887
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 61.2 bits (147), Expect = 7e-10
Identities = 48/149 (32%), Positives = 70/149 (46%), Gaps = 7/149 (4%)
Query: 31 LLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHL---CGH 87
L + G N +D GRT L LA ICQLL GAD+ + D Q TAL L G
Sbjct: 140 LCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 199
Query: 88 VDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKG---FNRGTH 144
D ++ L+ NG I + + G A R G N D++ LL++ E KG + +G
Sbjct: 200 RDAVEVLIKNGADISLLDALGHDSSYYA-RIGDNLDILTLLKTASENTNKGRELWKKGPS 258
Query: 145 SKLETMQTAESESAMESHSLLNPNLQQGE 173
+ + + E ++SH + N+Q E
Sbjct: 259 LQQRNLTHMQDEVNVKSHQREHQNIQDLE 287
Score = 52.0 bits (123), Expect = 4e-07
Identities = 34/96 (35%), Positives = 45/96 (46%), Gaps = 3/96 (3%)
Query: 23 GDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTAL 82
G+ +L G D D+ GR LHLAA G+ Q L ++ D QG TAL
Sbjct: 66 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTAL 125
Query: 83 HLCGHVD---TIQFLVSNGLKIDICNHQGATPLVLA 115
H D +IQ L +G ++ + G TPLVLA
Sbjct: 126 HDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLA 161
Score = 44.3 bits (103), Expect = 9e-05
Identities = 29/101 (28%), Positives = 47/101 (46%), Gaps = 4/101 (3%)
Query: 16 LLQACIDGDFNYSKRLL-ESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLAT 74
L++A GD +L + G +P D GR+ H+ ++GN++ + G D+ +
Sbjct: 25 LMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTS 84
Query: 75 DYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPL 112
D G ALHL GH +Q L+ + + QG T L
Sbjct: 85 DTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTAL 125
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,125,556
Number of Sequences: 37866
Number of extensions: 337116
Number of successful extensions: 3018
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 872
Number of HSP's gapped (non-prelim): 1448
length of query: 228
length of database: 18,247,518
effective HSP length: 99
effective length of query: 129
effective length of database: 14,498,784
effective search space: 1870343136
effective search space used: 1870343136
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.