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Search of human proteins with 38016904
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
(1074 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 2328 0.0
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 1843 0.0
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 697 0.0
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 339 7e-93
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 315 1e-85
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 282 1e-75
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 280 4e-75
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 273 5e-73
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 270 5e-72
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 263 7e-70
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 261 2e-69
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 257 4e-68
gi|145309328 papilin [Homo sapiens] 235 1e-61
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 225 2e-58
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 225 2e-58
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens] 225 2e-58
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 224 3e-58
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 220 5e-57
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 220 5e-57
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 220 5e-57
gi|226442878 ADAMTS-like 5 [Homo sapiens] 209 9e-54
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 190 5e-48
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 180 7e-45
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 176 1e-43
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 169 1e-41
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 169 1e-41
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 151 3e-36
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 149 1e-35
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 144 6e-34
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 141 3e-33
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 2328 bits (6034), Expect = 0.0
Identities = 1074/1074 (100%), Positives = 1074/1074 (100%)
Query: 1 MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC 60
MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC
Sbjct: 1 MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC 60
Query: 61 GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG 120
GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG
Sbjct: 61 GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG 120
Query: 121 RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR 180
RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR
Sbjct: 121 RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR 180
Query: 181 SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV 240
SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV
Sbjct: 181 SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV 240
Query: 241 APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD 300
APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD
Sbjct: 241 APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD 300
Query: 301 PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP 360
PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP
Sbjct: 301 PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP 360
Query: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL
Sbjct: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
Query: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD
Sbjct: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
Query: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW
Sbjct: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Query: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
Query: 781 RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP 840
RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP
Sbjct: 781 RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP 840
Query: 841 CTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDM 900
CTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDM
Sbjct: 841 CTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDM 900
Query: 901 RACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPP 960
RACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPP
Sbjct: 901 RACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPP 960
Query: 961 ALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPC 1020
ALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPC
Sbjct: 961 ALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPC 1020
Query: 1021 NSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLERSPQDPS 1074
NSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLERSPQDPS
Sbjct: 1021 NSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLERSPQDPS 1074
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 1843 bits (4774), Expect = 0.0
Identities = 855/857 (99%), Positives = 855/857 (99%)
Query: 1 MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC 60
MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC
Sbjct: 1 MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC 60
Query: 61 GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG 120
GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG
Sbjct: 61 GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG 120
Query: 121 RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR 180
RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR
Sbjct: 121 RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR 180
Query: 181 SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV 240
SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV
Sbjct: 181 SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV 240
Query: 241 APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD 300
APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD
Sbjct: 241 APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD 300
Query: 301 PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP 360
PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP
Sbjct: 301 PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP 360
Query: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL
Sbjct: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
Query: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD
Sbjct: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
Query: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW
Sbjct: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Query: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
Query: 781 RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP 840
RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP
Sbjct: 781 RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP 840
Query: 841 CTTAWFHSDWSSKCSAE 857
CTTAWFHSDWSSK S E
Sbjct: 841 CTTAWFHSDWSSKVSPE 857
Score = 109 bits (273), Expect = 1e-23
Identities = 76/246 (30%), Positives = 105/246 (42%), Gaps = 39/246 (15%)
Query: 741 PGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCG 800
PGT RQ++ Q PP H P + + + GH S CS CG
Sbjct: 639 PGTLQRQVRIPQ------MPAPP----HPRTPLGSPAAYWKRVGH-------SACSASCG 681
Query: 801 RGQRSRQVRCVG-NNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECG 859
+G C+ +G+E+ E+ CA+G P S E C PC W +W+S CS CG
Sbjct: 682 KGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTS-CSRSCG 740
Query: 860 TGIQRRSVVCL----GSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWY 915
G Q R + C G G+++ P + C RP ++C L C W
Sbjct: 741 PGTQHRQLQCRQEFGGGGSSVPP----------ERCGHLPRPNITQSCQLRLC---GHWE 787
Query: 916 TG-PWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRW 974
G PW +CS CG G + R + CV G E V+ S P+PP+ + C C W
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDE--VSEQECASGPPQPPSREACDMGPCTTAW 845
Query: 975 FSTPWS 980
F + WS
Sbjct: 846 FHSDWS 851
Score = 109 bits (272), Expect = 2e-23
Identities = 64/183 (34%), Positives = 83/183 (45%), Gaps = 22/183 (12%)
Query: 852 SKCSAECGTGIQRRSVVCLG--SGAALGPGQGEAGAGTGQSCPTGSRPP-DMRACSLGPC 908
S CSA CG G+ R +C+ SG L +SC G+RPP C PC
Sbjct: 674 SACSASCGKGVWRPIFLCISRESGEELDE----------RSCAAGARPPASPEPCHGTPC 723
Query: 909 ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQ 968
W G W CS CG GTQ R + C + G + P C HLPRP Q CQ +
Sbjct: 724 PPYWE--AGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLR 781
Query: 969 ACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTN--QTLSTRC---PPQLRPSRKRPCNSQ 1023
C +PWS CS C G ++R+V+C+ N + C PPQ P + C+
Sbjct: 782 LCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQ--PPSREACDMG 839
Query: 1024 PCS 1026
PC+
Sbjct: 840 PCT 842
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/109 (36%), Positives = 54/109 (49%), Gaps = 5/109 (4%)
Query: 922 CSSECGSGTQRRDIICVSK-LGTEFNVTSPSNCSHLPRPPAL-QPCQGQACQDRWFSTPW 979
CS+ CG G R +C+S+ G E + S C+ RPPA +PC G C W + W
Sbjct: 676 CSASCGKGVWRPIFLCISRESGEELDERS---CAAGARPPASPEPCHGTPCPPYWEAGEW 732
Query: 980 SPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQR 1028
+ CSRSC GTQ R++QC + PP+ RP +Q C R
Sbjct: 733 TSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLR 781
Score = 31.2 bits (69), Expect = 5.5
Identities = 27/80 (33%), Positives = 31/80 (38%), Gaps = 15/80 (18%)
Query: 820 EQECASGPP-QPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGP 878
+QE SG Q P+ E W W+S CS CG G+QRRS C L P
Sbjct: 24 DQEVLSGHSLQTPTEEGQGPEGVWGPWVQ--WAS-CSQPCGVGVQRRSRTCQLPTVQLHP 80
Query: 879 GQGEAGAGTGQSCPTGSRPP 898
S P RPP
Sbjct: 81 -----------SLPLPPRPP 89
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 697 bits (1800), Expect = 0.0
Identities = 403/1060 (38%), Positives = 533/1060 (50%), Gaps = 129/1060 (12%)
Query: 40 GQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRG 99
G G GVWG W W++CS+ C GV ++R C P + RG
Sbjct: 49 GGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCL-------------------PRSYRLRG 89
Query: 100 QGPRPQTSPETLPLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGY 159
G RP G P R A H+ + A R S
Sbjct: 90 -GQRP-----------------GAPARAFADHV-------VSAVRTS------------- 111
Query: 160 GRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTE--LPPT 217
+PLHR+R + ++ S P P+ + + +T + P
Sbjct: 112 ------VPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPG 165
Query: 218 ELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEP--PSPTHSLGEGGFF 275
+ + +P PL +TA T R + RH AS SP H + + G
Sbjct: 166 KYG-YGKAPYILPLQTDTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHG-- 222
Query: 276 RASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHP 335
P S G S A P +P QG H P E H
Sbjct: 223 -----PLYQSDSGPRSGLQAAEAP--IYQLPL---THDQGYPAASSLFHSP--ETSNNH- 269
Query: 336 GAWLPLLSNGPH-ASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCAAF 394
G H A+ +S A S+ I C G Q + C+ CP R +QCA++
Sbjct: 270 -------GVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASY 321
Query: 395 NSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAG 454
N++ FMG+ Y+WEPF EV+G+++CELNC+ G+RFYVR EKV DGT C ICV+G
Sbjct: 322 NNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSG 381
Query: 455 RCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQ 514
+C S GCD LGS + D CGVCGGD++ C++VSG LGY +++ IP GA ++
Sbjct: 382 QCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKIN 441
Query: 515 IAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPR-EEGKGESLSAE 573
I ++ S+NYLALR GRSIINGNWA+D PG Y GGT+F Y RP GES AE
Sbjct: 442 ITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
Query: 574 GPTTQPVDVYMIFQEENPGVFYQYVISSPPPILENPTP-----EPPVPQL---------- 618
GPT + +DVYMI Q+ NPGV Y+YVI I P EP Q+
Sbjct: 502 GPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEG 561
Query: 619 -------QPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMP---APPHPRTPLGSPAAYW 668
+ E LR E P A+T P P PP P+ P S W
Sbjct: 562 EQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNW 621
Query: 669 KRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWE 728
K++G + CS +CGKG PIF C+ R + EE E C + +P EPC+ PCP +W+
Sbjct: 622 KQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWD 681
Query: 729 AGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEV 788
GEW+ CS++CG G QHRQ+ CRQ + +V P RC HL +P T +CQL++C W++
Sbjct: 682 IGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQI 741
Query: 789 GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
+ W+ CSV CG GQR+R V+CV N GD V ++EC + +P E CDMGPC +WF +
Sbjct: 742 RTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEEC-NMKLRPNDIENCDMGPCAKSWFLT 800
Query: 849 DWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC 908
+WS +CSAECG G++ RSVVC+ + + P +G C +RP + C GPC
Sbjct: 801 EWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG---------C-GNNRPAEATPCDNGPC 850
Query: 909 ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQ 968
W+ G W +CS ECGSGTQ+R++ICV K F V PS CS L +PP+ Q C +
Sbjct: 851 TGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLK 910
Query: 969 ACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQR 1028
C +WFST WS CS+SCQGG + REV+CLS + TLS C PQL+P + CN Q C
Sbjct: 911 PCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE 970
Query: 1029 PDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLER 1068
D+ CKD +C +VVQARLCVY YY CC SC V R
Sbjct: 971 VDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANR 1010
Score = 33.9 bits (76), Expect = 0.85
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 6/53 (11%)
Query: 699 ELDERSCAAGARPPASPEPCHGTPCPPYWEA-GEWTSCSRSCGPGTQHRQLQC 750
++ +R A GA PE G P W A G W++CSRSC G + C
Sbjct: 33 KVPQRMAAEGA-----PEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 339 bits (870), Expect = 7e-93
Identities = 210/713 (29%), Positives = 309/713 (43%), Gaps = 137/713 (19%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G S + C+ PC D RA QCA +NS+ F G YQW+P+T+V+ RC+L C+
Sbjct: 628 CPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCK 687
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
F F+ + KV+DGT C P D+C+ G C GCD LGS D CGVC GD+ST
Sbjct: 688 AENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNST 747
Query: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
C+ G ++ Y ++ IPAGA ++I +L+ SS+YLA+R + + G W++D
Sbjct: 748 CKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSID 807
Query: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPP 603
PG + GT F Y R + E L A GPT + + ++ Q +NPG+ ++Y +
Sbjct: 808 WPGEFPFAGTTFEYQ---RSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYAL---- 860
Query: 604 PILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGS 663
P+++ PP P
Sbjct: 861 ----------------PKVMNGTPPATKRP------------------------------ 874
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
AY + S CS SCG G +C+ R+ +++ C+A +P P+ C+ C
Sbjct: 875 --AYTWSIVQSECSVSCGGGYINVKAICL-RDQNTQVNSSFCSAKTKPVTEPKICNAFSC 931
Query: 724 PPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
P YW GEW++CS++C G Q R++QC Q+ + P Q+C C
Sbjct: 932 PAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHAC 991
Query: 784 -GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC- 841
W +G PWSQCS CGRG R R++ C G+ + + E +C S P+P +E C +G C
Sbjct: 992 PPQWSLG-PWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTS-LPRPELQEGCVLGRCP 1049
Query: 842 ---TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPP 898
W S W S+CSA CG G+++R + C G QG+ + C +P
Sbjct: 1050 KNSRLQWVASSW-SECSATCGLGVRKREMKCSEKGF-----QGKLITFPERRCRNIKKPN 1103
Query: 899 -------DMRACSLGPC-ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSP 950
+ RAC P WY+ PW +C+ CG G Q R + CV +
Sbjct: 1104 LDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ------GRPS 1157
Query: 951 SNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPP 1010
S+C +PP L+ C C
Sbjct: 1158 SSCLLHQKPPVLRACNTNFC---------------------------------------- 1177
Query: 1011 QLRPSRKRPCNSQPCSQRPDD-QCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
P ++ +D C D C LV Q +C + +Y CC+SC
Sbjct: 1178 -------------PAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSC 1217
Score = 38.5 bits (88), Expect = 0.034
Identities = 14/33 (42%), Positives = 19/33 (57%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
G W W +W+ CS+ CG GV+ + R C P Q
Sbjct: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ 622
Score = 35.0 bits (79), Expect = 0.38
Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 24/89 (26%)
Query: 715 PEPCHGTPCPPYWEA-GEWTSCSRSCGPGTQHRQLQC---RQEFGG---GGSSVPPERCG 767
P P HG W A +W+ CSR+CG G + ++ C + ++GG GSS
Sbjct: 585 PRPIHGQ-----WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSS------- 632
Query: 768 HLPRPNITQSCQLRLCGHWEVGSPWSQCS 796
I Q C + C + QC+
Sbjct: 633 -----RIYQLCNINPCNENSLDFRAQQCA 656
Score = 33.5 bits (75), Expect = 1.1
Identities = 29/103 (28%), Positives = 39/103 (37%), Gaps = 25/103 (24%)
Query: 739 CGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVR 798
CG RQ QC +FG G PRP + G W S WS+CS
Sbjct: 566 CGLSMWCRQGQC-VKFGELG-----------PRP---------IHGQWSAWSKWSECSRT 604
Query: 799 CGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
CG G + ++ C N + C P + C++ PC
Sbjct: 605 CGGGVKFQERHC-NNPKPQYGGLFC---PGSSRIYQLCNINPC 643
Score = 33.1 bits (74), Expect = 1.4
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 979 WSPCSRSCQGGTQTREVQCLSTN-QTLSTRCPPQLRPSRKRPCNSQPCSQRPDD 1031
WS CSR+C GG + +E C + Q CP R + CN PC++ D
Sbjct: 598 WSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQL--CNINPCNENSLD 649
Score = 31.6 bits (70), Expect = 4.2
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 8/48 (16%)
Query: 43 PEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHP-----SLPLP 85
P+ GPW Q CS+ CG GV++R C+ + P SLP P
Sbjct: 993 PQWSLGPWSQ---CSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRP 1037
Score = 30.8 bits (68), Expect = 7.2
Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Query: 40 GQGPEGVWGPWV--QWASCSQPCGVGVQRRSRTC 71
G+ P+ WV W+ CS CG+GV++R C
Sbjct: 1046 GRCPKNSRLQWVASSWSECSATCGLGVRKREMKC 1079
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 315 bits (808), Expect = 1e-85
Identities = 222/783 (28%), Positives = 320/783 (40%), Gaps = 158/783 (20%)
Query: 313 GQGPWGTGG--TPHGPRLEPDPQHPGAWLPLLSNGP----------HASSLWSLFAPSSP 360
G W GG +G P P H G W S P H S L + PS
Sbjct: 564 GHDMWCRGGQCVKYGDE-GPKPTH-GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
Query: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
C G + L+ C+ CP + D RA QCA NS+ F G+ Y+W+P+T+V+ C+L
Sbjct: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKL 681
Query: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
C GF F+ + KV+DGT C + ++C+ G C GCD +LGS D CGVC G+
Sbjct: 682 YCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGN 741
Query: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
+S C + G T Y ++ IP+GA ++I ++ S++Y+++R R +NG+W
Sbjct: 742 NSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHW 801
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
VD PG Y+ GT F Y R E E+L A GPT + + V ++FQ NPGV ++Y
Sbjct: 802 TVDWPGRYKFSGTTFDYRRSYNEP---ENLIATGPTNETLIVELLFQGRNPGVAWEY--- 855
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
+P+L E +PP P
Sbjct: 856 -------------SMPRLGTE---KQPPAQP----------------------------- 870
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
+Y + S CS SCG G C R+ +++ C RP PC
Sbjct: 871 -----SYTWAIVRSECSVSCGGGQMTVREGCY-RDLKFQVNMSFCNPKTRPVTGLVPCKV 924
Query: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
+ CPP W G W++CSR+CG G Q R +QC + VP C P P+ Q+C
Sbjct: 925 SACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ-PAPSSRQACNS 983
Query: 781 RLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGD---EVSEQECASGPPQPPSREAC 836
+ C W G PW++CS CG+G R R V C N ++ + P+P EAC
Sbjct: 984 QSCPPAWSAG-PWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 837 DMGPC----TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCP 892
+ C W S W S+CS C G Q+R + C + G+ + C
Sbjct: 1043 LLQRCHKPKKLQWLVSAW-SQCSVTCERGTQKRFLKCAEKYVS-----GKYRELASKKCS 1096
Query: 893 TGSRP--PDMRACSLGPCER----------TWRWYTGPWGECSSECGSGTQRRDIICVSK 940
+P RAC+ PC R W+ PW +C++ CG G Q R + C++
Sbjct: 1097 HLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLA- 1155
Query: 941 LGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLST 1000
S C +P A C C
Sbjct: 1156 -----GGRPASGCLLHQKPSASLACNTHFC------------------------------ 1180
Query: 1001 NQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCR 1060
P +++ D CKD C LV Q +C + +Y CC+
Sbjct: 1181 -----------------------PIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCK 1217
Query: 1061 SCA 1063
+C+
Sbjct: 1218 TCS 1220
Score = 42.4 bits (98), Expect = 0.002
Identities = 18/38 (47%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 38 EEGQGP-EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
+EG P G W W W+ CS+ CG GV RSR C P
Sbjct: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNP 616
Score = 32.3 bits (72), Expect = 2.5
Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 8/58 (13%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLP-------PRPPRHPEALLPRGQGPR 103
WA CS CG G ++R+ C+ L LP P+P H LL R P+
Sbjct: 995 WAECSHTCGKGWRKRAVACKSTNPSARAQL-LPDAVCTSEPKPRMHEACLLQRCHKPK 1051
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 282 bits (722), Expect = 1e-75
Identities = 204/716 (28%), Positives = 299/716 (41%), Gaps = 101/716 (14%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF----MGQLYQWEP-FTEVQGSQRC 418
C G + R+C+ CP D R QC+ FN + + +W P ++ + RC
Sbjct: 595 CVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRC 654
Query: 419 ELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
+L C+ G ++ + V+DGT C DICV G+C++ GCD +L S + D CGVCG
Sbjct: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
Query: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQL----RPSSNYLALRGPGGRS 534
GD+S+C+ ++G GY ++ IPAGA + I Q +P +YLAL G
Sbjct: 715 GDNSSCKTITGVFNS--SHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNF 772
Query: 535 IINGNWAVDPPG---SYRAGGTVFRYNRPPREEGKGESLSAEGPTTQP-----VDVYMIF 586
+ NGN+ + + + TV Y+ G ++ T + + V +
Sbjct: 773 LFNGNFLLSTSKKEINVQGTRTVIEYS------GSNNAVERINSTNRQEKELILQVLCVG 826
Query: 587 QEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQ- 645
NP V Y + I P + + P P + LQR+
Sbjct: 827 NLYNPDVHYSFNI----------------PLEERSDMFTWDPYGPWEGCTKMCQGLQRRN 870
Query: 646 --------------VRIPQMPAPPHPRTPLGSPAAY-WKRVGHSACSASCGKGVWRPIFL 690
+P P + W +G S CS+ CG+G
Sbjct: 871 ITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQGYRTLDIH 930
Query: 691 CISRESGE----ELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHR 746
C+ E ++D+ C +PP E CHG W EW+ CSRSCG G + R
Sbjct: 931 CMKYSIHEGQTVQVDDHYCGDQLKPPTQ-ELCHGNCVFTRWHYSEWSQCSRSCGGGERSR 989
Query: 747 QLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSR 806
+ C F G + C L R ++C C W S WS+C V CG+G + R
Sbjct: 990 ESYCMNNF---GHRLADNECQELSRVT-RENCNEFSCPSW-AASEWSECLVTCGKGTKQR 1044
Query: 807 QVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRS 866
QV C N D +S+ C S +P S C++ C +W W C+ CG G Q R
Sbjct: 1045 QVWC-QLNVDHLSDGFCNSS-TKPESLSPCELHTC-ASWQVGPW-GPCTTTCGHGYQMRD 1100
Query: 867 VVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC----------------ER 910
V C+ A+ E C SRP D ++C L PC ++
Sbjct: 1101 VKCVNELASAVLEDTE--------CHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKK 1152
Query: 911 TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
+W G W CS CG GTQ R + C L + S C+HLPRP + C
Sbjct: 1153 MAQWRHGSWTPCSVSCGRGTQARYVSCRDALD---RIADESYCAHLPRPAEIWDCFTPC- 1208
Query: 971 QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTR-CPPQLRPSRKRPCNSQPC 1025
W + WSPCS SC G TR+V C++ +Q + C P++RP ++ C+ C
Sbjct: 1209 -GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAAC 1263
Score = 183 bits (464), Expect = 9e-46
Identities = 132/444 (29%), Positives = 176/444 (39%), Gaps = 87/444 (19%)
Query: 666 AYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP- 724
A W+ C+ +CG G C++ + L++ C +RP + + C TPC
Sbjct: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRP-SDRQSCVLTPCSF 1136
Query: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
W G WT CS SCG GTQ R + CR C
Sbjct: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD---RIADESYCA 1193
Query: 768 HLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG--DE-------- 817
HLPRP C CG W+ G WS CS CG G+ +RQV C+ + DE
Sbjct: 1194 HLPRPAEIWDC-FTPCGEWQAGD-WSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
Query: 818 -VSEQECA------------SGPPQPPSREACDMGPCT-----------------TAWFH 847
+ EQEC+ S P QP + ++ P T W
Sbjct: 1252 PLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNL-PLTQKLEDNENQVVHPSVRGNQWRT 1310
Query: 848 SDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGP 907
W S CS+ C G+Q R+VVC Q E G C S+PP+++ C GP
Sbjct: 1311 GPWGS-CSSSCSGGLQHRAVVC----------QDENGQSASY-CDAASKPPELQQCGPGP 1358
Query: 908 CERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQG 967
C + W G WGECS CG G + R +IC G + NC + +PP++ C
Sbjct: 1359 CPQ---WNYGNWGECSQTCGGGIKSRLVICQFPNG---QILEDHNCEIVNKPPSVIQCHM 1412
Query: 968 QACQD--RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL--STRCPPQLRPSRKRPCNSQ 1023
AC W PW+ CS SC G + REV C+ Q T C +P + C S
Sbjct: 1413 HACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSV 1472
Query: 1024 PCSQRPDDQCKDSSPHCPLVVQAR 1047
C + + S C VQ R
Sbjct: 1473 RCPSWKANSWNECSVTCGSGVQQR 1496
Score = 179 bits (455), Expect = 1e-44
Identities = 118/414 (28%), Positives = 165/414 (39%), Gaps = 73/414 (17%)
Query: 659 TPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
T L A W+ + CS SCG+G C R++ + + + S A PA C
Sbjct: 1147 TVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC--RDALDRIADESYCAHLPRPAEIWDC 1204
Query: 719 HGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSC 778
TPC W+AG+W+ CS SCG G RQ+ C + C RP + Q C
Sbjct: 1205 F-TPCGE-WQAGDWSPCSASCGHGKTTRQVLCMNYH----QPIDENYCDPEVRPLMEQEC 1258
Query: 779 QLRLC------------------------------------------GHWEVGSPWSQCS 796
L C W G PW CS
Sbjct: 1259 SLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTG-PWGSCS 1317
Query: 797 VRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSA 856
C G + R V C NG S + AS +PP + C GPC W + +W +CS
Sbjct: 1318 SSCSGGLQHRAVVCQDENGQSASYCDAAS---KPPELQQCGPGPCPQ-WNYGNWG-ECSQ 1372
Query: 857 ECGTGIQRRSVVC-LGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWY 915
CG GI+ R V+C +G L +C ++PP + C + C W+
Sbjct: 1373 TCGGGIKSRLVICQFPNGQIL----------EDHNCEIVNKPPSVIQCHMHACPADVSWH 1422
Query: 916 TGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWF 975
PW CS+ CG G + R++ C+ + + T NCS + +PP + C+ C W
Sbjct: 1423 QEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT---NCSQVQKPPTHKACRSVRCPS-WK 1478
Query: 976 STPWSPCSRSCQGGTQTREVQC--LSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
+ W+ CS +C G Q R+V C Q + C RP +R C SQ C Q
Sbjct: 1479 ANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQ 1532
Score = 159 bits (401), Expect = 2e-38
Identities = 119/442 (26%), Positives = 169/442 (38%), Gaps = 80/442 (18%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W S CS SCG G C++ G L + C +R + E C+ CP W
Sbjct: 970 WHYSEWSQCSRSCGGGERSRESYCMNN-FGHRLADNECQELSR--VTRENCNEFSCPS-W 1025
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
A EW+ C +CG GT+ RQ+ C+ + C +P C+L C W+
Sbjct: 1026 AASEWSECLVTCGKGTKQRQVWCQLNV----DHLSDGFCNSSTKPESLSPCELHTCASWQ 1081
Query: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCT----- 842
VG PW C+ CG G + R V+CV V E +P R++C + PC+
Sbjct: 1082 VG-PWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL 1140
Query: 843 -------------TAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
W H W+ CS CG G Q R V C AL E+
Sbjct: 1141 ETALLPTVLIKKMAQWRHGSWTP-CSVSCGRGTQARYVSCRD---ALDRIADES------ 1190
Query: 890 SCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSK--------- 940
C RP ++ C PC W G W CS+ CG G R ++C++
Sbjct: 1191 YCAHLPRPAEIWDC-FTPCGE---WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYC 1246
Query: 941 -------LGTEFNVTS-PSNCSHLPRPPA---------------LQPCQGQACQ-----D 972
+ E ++ + P SH P P L+ + Q +
Sbjct: 1247 DPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGN 1306
Query: 973 RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQ 1032
+W + PW CS SC GG Q R V C N ++ C +P + C PC Q
Sbjct: 1307 QWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGN 1366
Query: 1033 CKDSSPHCPLVVQARL--CVYP 1052
+ S C +++RL C +P
Sbjct: 1367 WGECSQTCGGGIKSRLVICQFP 1388
Score = 144 bits (364), Expect = 3e-34
Identities = 105/375 (28%), Positives = 156/375 (41%), Gaps = 46/375 (12%)
Query: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSC 735
C+ C +G+ R CI + + ++ C P + C+ T C W + C
Sbjct: 859 CTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCN-TDCELRWHVIGKSEC 916
Query: 736 SRSCGPGTQHRQLQCRQEFGGGGSSVPPE--RCGHLPRPNITQSCQLR-LCGHWEVGSPW 792
S CG G + + C + G +V + CG +P + C + W S W
Sbjct: 917 SSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHY-SEW 975
Query: 793 SQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSS 852
SQCS CG G+RSR+ C+ N G +++ EC +RE C+ C +W S+W S
Sbjct: 976 SQCSRSCGGGERSRESYCMNNFGHRLADNECQE--LSRVTRENCNEFSC-PSWAASEW-S 1031
Query: 853 KCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTW 912
+C CG G ++R V C + L G C + ++P + C L C
Sbjct: 1032 ECLVTCGKGTKQRQVWCQLNVDHLSDG----------FCNSSTKPESLSPCELHTCA--- 1078
Query: 913 RWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC-- 970
W GPWG C++ CG G Q RD+ CV++L + V + C RP Q C C
Sbjct: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASA--VLEDTECHEASRPSDRQSCVLTPCSF 1136
Query: 971 ----------------QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLS--TRCPPQL 1012
+W W+PCS SC GTQ R V C ++ + C
Sbjct: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLP 1196
Query: 1013 RPSRKRPCNSQPCSQ 1027
RP+ C + PC +
Sbjct: 1197 RPAEIWDCFT-PCGE 1210
Score = 143 bits (361), Expect = 8e-34
Identities = 108/379 (28%), Positives = 139/379 (36%), Gaps = 70/379 (18%)
Query: 663 SPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTP 722
+P W+ S CSASCG G LC++ + +DE C RP E C
Sbjct: 1206 TPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYH--QPIDENYCDPEVRPLMEQE-CSLAA 1262
Query: 723 CPP-----------------------------------------YWEAGEWTSCSRSCGP 741
CPP W G W SCS SC
Sbjct: 1263 CPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG 1322
Query: 742 GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGR 801
G QHR + C+ E G S C +P Q C C W G+ W +CS CG
Sbjct: 1323 GLQHRAVVCQDENGQSAS-----YCDAASKPPELQQCGPGPCPQWNYGN-WGECSQTCGG 1376
Query: 802 GQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC--TTAWFHSDWSSKCSAECG 859
G +SR V C NG + + C +PPS C M C +W W+S CSA CG
Sbjct: 1377 GIKSRLVICQFPNGQILEDHNCEI-VNKPPSVIQCHMHACPADVSWHQEPWTS-CSASCG 1434
Query: 860 TGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPW 919
G + R V C+ +C +PP +AC C W W
Sbjct: 1435 KGRKYREVFCIDQFQR---------KLEDTNCSQVQKPPTHKACRSVRCP---SWKANSW 1482
Query: 920 GECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC-QDRWFSTP 978
ECS CGSG Q+RD+ C K C RP + + C Q C Q +
Sbjct: 1483 NECSVTCGSGVQQRDVYCRLK---GVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERG 1539
Query: 979 WSPCSRSCQGGTQTREVQC 997
CS SC+ + ++C
Sbjct: 1540 RLNCSTSCERKDSHQRMEC 1558
Score = 119 bits (298), Expect = 2e-26
Identities = 97/386 (25%), Positives = 149/386 (38%), Gaps = 38/386 (9%)
Query: 654 PPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPA 713
PP + P W CS +CG G+ + +C +G+ L++ +C +PP
Sbjct: 1348 PPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVNKPP- 1405
Query: 714 SPEPCHGTPCPP--YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR 771
S CH CP W WTSCS SCG G ++R++ C +F + C + +
Sbjct: 1406 SVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQF---QRKLEDTNCSQVQK 1462
Query: 772 PNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
P ++C+ C W+ S W++CSV CG G + R V C +V E+ C +P
Sbjct: 1463 PPTHKACRSVRCPSWKANS-WNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQS-TRPC 1520
Query: 832 SREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSC 891
S+ C C CS C + + C + E +
Sbjct: 1521 SQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIR---QVNEIVYNSSTIS 1577
Query: 892 PTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPS 951
T + C PC + T +C++ CG ++R C TE T
Sbjct: 1578 LTS------KNCRNPPC--NYIVVTADSSQCANNCGFSYRQRITYC-----TEIPSTKKH 1624
Query: 952 NCSHLPRPPALQPC------QGQACQD------RWFSTPWSPCSRSCQGGTQTREVQCLS 999
H RP Q C Q C + W WS CS +C G R+V+C++
Sbjct: 1625 KL-HRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCIT 1683
Query: 1000 TNQTLSTRCPPQLRPSRKRPCNSQPC 1025
+ S C L+P ++ C + C
Sbjct: 1684 KHGLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 99.4 bits (246), Expect = 2e-20
Identities = 73/296 (24%), Positives = 114/296 (38%), Gaps = 65/296 (21%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE-VSEQECASGPPQPPSREACDMGPCTTA 844
W+ PW C+ C +G + R + C+ + VS++EC P ++C+ C
Sbjct: 850 WDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNT-DCELR 907
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
W H S+CS++CG G + + C+ +G+ C +PP C
Sbjct: 908 W-HVIGKSECSSQCGQGYRTLDIHCM----KYSIHEGQTVQVDDHYCGDQLKPPTQELCH 962
Query: 905 LGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLG---------------------- 942
G C T RW+ W +CS CG G + R+ C++ G
Sbjct: 963 -GNCVFT-RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEF 1020
Query: 943 ---------------------------TEFNVTSPSN--CSHLPRPPALQPCQGQACQDR 973
+ NV S+ C+ +P +L PC+ C
Sbjct: 1021 SCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCAS- 1079
Query: 974 WFSTPWSPCSRSCQGGTQTREVQC---LSTNQTLSTRCPPQLRPSRKRPCNSQPCS 1026
W PW PC+ +C G Q R+V+C L++ T C RPS ++ C PCS
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCS 1135
Score = 63.9 bits (154), Expect = 8e-10
Identities = 61/243 (25%), Positives = 89/243 (36%), Gaps = 41/243 (16%)
Query: 650 QMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGA 709
Q+ PP + WK + CS +CG GV + C + G+ ++E C
Sbjct: 1459 QVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEM-CDQST 1517
Query: 710 RPPASPEPCHGTPCPPY--WEAGEWTSCSRSCGPGTQHRQLQCRQE---------FGGGG 758
RP S C C + E G +CS SC H++++C +
Sbjct: 1518 RP-CSQRRCWSQDCVQHKGMERGR-LNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSST 1575
Query: 759 SSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE- 817
S+ + C + P C + V + SQC+ CG R R C +
Sbjct: 1576 ISLTSKNCRNPP------------CNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKK 1623
Query: 818 --------VSEQECASGPPQPPSREACDMGPCT--TAWFHSDWSSKCSAECGTGIQRRSV 867
+ QEC P P S+ + C W WS KCS CG GI +R V
Sbjct: 1624 HKLHRLRPIVYQEC---PVVPSSQVYQCINSCLHLATWKVGKWS-KCSVTCGIGIMKRQV 1679
Query: 868 VCL 870
C+
Sbjct: 1680 KCI 1682
Score = 41.6 bits (96), Expect = 0.004
Identities = 14/30 (46%), Positives = 20/30 (66%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G WGPW ++SCS+ CG G++ +R C P
Sbjct: 557 GEWGPWEPYSSCSRTCGGGIESATRRCNRP 586
Score = 35.8 bits (81), Expect = 0.22
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 40 GQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL 78
G GP W + W CSQ CG G++ R CQ P Q+
Sbjct: 1355 GPGPCPQWN-YGNWGECSQTCGGGIKSRLVICQFPNGQI 1392
Score = 34.3 bits (77), Expect = 0.65
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 13/99 (13%)
Query: 7 RPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQR 66
+P YL L L Q D E H + GP W SCS C G+Q
Sbjct: 1276 QPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGP---------WGSCSSSCSGGLQH 1326
Query: 67 RSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
R+ CQ Q +PP L G GP PQ
Sbjct: 1327 RAVVCQDENGQSASYCDAASKPPE----LQQCGPGPCPQ 1361
Score = 31.2 bits (69), Expect = 5.5
Identities = 33/117 (28%), Positives = 46/117 (39%), Gaps = 29/117 (24%)
Query: 924 SECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCS 983
++CG G R +CV+K TE T P N P W P+S CS
Sbjct: 532 TDCGPGMHCRHGLCVNK-ETE---TRPVNGEWGP----------------W--EPYSSCS 569
Query: 984 RSCQGGTQTREVQCLSTN-QTLSTRCPPQLRPSRKRPCNSQPCSQRPDD----QCKD 1035
R+C GG ++ +C + C R + R CN+ C + D QC D
Sbjct: 570 RTCGGGIESATRRCNRPEPRNGGNYCVG--RRMKFRSCNTDSCPKGTQDFREKQCSD 624
Score = 30.4 bits (67), Expect = 9.4
Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 2/41 (4%)
Query: 31 HSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
+S P EE + W P+ W C++ C G+QRR+ TC
Sbjct: 835 YSFNIPLEE-RSDMFTWDPYGPWEGCTKMC-QGLQRRNITC 873
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 280 bits (717), Expect = 4e-75
Identities = 218/718 (30%), Positives = 311/718 (43%), Gaps = 93/718 (12%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFM--GQL--YQWEP-FTEVQGSQRC 418
C G + ++C+ PC ++ D R QCA F+ + F G L +W P ++ + RC
Sbjct: 627 CVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRC 686
Query: 419 ELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
+L CR G Y + ++V DGT C DICV G C GCD +L S R D CGVCG
Sbjct: 687 KLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCG 746
Query: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSS-----NYLALRGPGGR 533
GD+S+C+ V+G T GY ++ IPAGA + + Q S NYLAL G
Sbjct: 747 GDNSSCKTVAG--TFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGE 804
Query: 534 SIINGNWAVD-PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPV--DVYMIFQEEN 590
++NGN+ V R G V Y+ E E +++ Q + V + + N
Sbjct: 805 FLLNGNFVVTMAKREIRIGNAVVEYSG---SETAVERINSTDRIEQELLLQVLSVGKLYN 861
Query: 591 PGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQV---- 646
P V Y + I PI + P Q P +P + G +R++
Sbjct: 862 PDVRYSFNI----PIEDKP---------QQFYWNSHGPWQACSKPCQ--GERKRKLVCTR 906
Query: 647 ----------RIPQMPAPPHPRTPLGSPAAY-WKRVGHSACSASCGKGVWRPIFLCI--S 693
R ++P P H P G+ W S CSA CG G C S
Sbjct: 907 ESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYS 966
Query: 694 RESG--EELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCR 751
R G E++D+ C++ +P ++ E C G W WT CS+SC GTQ R+ C
Sbjct: 967 RLDGKTEKVDDGFCSSHPKP-SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAIC- 1024
Query: 752 QEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCV 811
+ +C H + I Q C C W+ G WS+C V CG+G + RQV C
Sbjct: 1025 --VNTRNDVLDDSKCTHQEKVTI-QRCSEFPCPQWKSGD-WSECLVTCGKGHKHRQVWCQ 1080
Query: 812 GNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
D ++++ C +P S + C C +W W +CS CG G Q R+V C+
Sbjct: 1081 FGE-DRLNDRMC-DPETKPTSMQTCQQPEC-ASWQAGPW-GQCSVTCGQGYQLRAVKCI- 1135
Query: 872 SGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCE----------------RTWRWY 915
+G C +RP D + C L C RT +W
Sbjct: 1136 ----IGTYMSVV---DDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRT-QWR 1187
Query: 916 TGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWF 975
G W CS+ CG GT+ R + C + G +V S C+ LPRP A + C C +W
Sbjct: 1188 FGSWTPCSATCGKGTRMRYVSCRDENG---SVADESACATLPRPVAKEECSVTPC-GQWK 1243
Query: 976 STPWSPCSRSCQGGTQTREVQCLSTNQTLSTR--CPPQLRPSRKRPCNSQPCSQRPDD 1031
+ WS CS +C G TR+V C++ + + R C P + C+ PC QR D
Sbjct: 1244 ALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPD 1301
Score = 198 bits (503), Expect = 3e-50
Identities = 124/391 (31%), Positives = 172/391 (43%), Gaps = 30/391 (7%)
Query: 654 PPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPA 713
P R P W C+ CG G+ + +C R +GE + SC +PP
Sbjct: 1372 PDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVC-QRSNGERFPDLSCEILDKPP- 1429
Query: 714 SPEPCHGTPCP--PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR 771
E C+ CP W G W+SCS SCG G + R + C + GS + + C HL +
Sbjct: 1430 DREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAK---DGSHLESDYCKHLAK 1486
Query: 772 PNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
P+ + C+ C W+ G+ WSQCSV CGRG + R V C E EC + +P
Sbjct: 1487 PHGHRKCRGGRCPKWKAGA-WSQCSVSCGRGVQQRHVGCQIGTHKIARETEC-NPYTRPE 1544
Query: 832 SREACDMGPCTT-AWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQS 890
S C C W +W +C+ CG G + R VVC+ G
Sbjct: 1545 SERDCQGPRCPLYTWRAEEWQ-ECTKTCGEGSRYRKVVCVDDNK---------NEVHGAR 1594
Query: 891 CPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIIC----VSKLGTEFN 946
C RP D +CSL PCE + W TG W ECS CG G ++R + C K E++
Sbjct: 1595 CDVSKRPVDRESCSLQPCE--YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYS 1652
Query: 947 VTSPSNCSHLPRPPALQPCQGQAC--QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL 1004
+ NC +PP++ PC + C W W CS SC G R VQCL+
Sbjct: 1653 YQTTINCPGT-QPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQP 1711
Query: 1005 STRCPPQLRPSRKRPCNSQPCSQRPDDQCKD 1035
S C L+P ++ C + + P + CK+
Sbjct: 1712 SHLCHTDLKPEERKTCRNVYNCELPQN-CKE 1741
Score = 195 bits (496), Expect = 2e-49
Identities = 127/413 (30%), Positives = 172/413 (41%), Gaps = 61/413 (14%)
Query: 649 PQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAG 708
P AP R+ +P W+ + CSA+CGKG R ++ E+G DE +CA
Sbjct: 1167 PPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGT-RMRYVSCRDENGSVADESACATL 1225
Query: 709 ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGH 768
RP A E C TPC W+A +W+SCS +CG G RQ+ C + C
Sbjct: 1226 PRPVAKEE-CSVTPCGQ-WKALDWSSCSVTCGQGRATRQVMC---VNYSDHVIDRSECDQ 1280
Query: 769 LPRPNITQSCQLRLC----------------------------------GHWEVGSPWSQ 794
P Q C + C W G PW
Sbjct: 1281 DYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTG-PWGA 1339
Query: 795 CSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKC 854
CS C G + R V C NG + +C +P + AC+ GPC W + +W +C
Sbjct: 1340 CSSTCAGGSQRRVVVCQDENG--YTANDCVERI-KPDEQRACESGPCPQ-WAYGNWG-EC 1394
Query: 855 SAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRW 914
+ CG GI+ R VVC S P SC +PPD C+ C W
Sbjct: 1395 TKLCGGGIRTRLVVCQRSNGERFPDL---------SCEILDKPPDREQCNTHACPHDAAW 1445
Query: 915 YTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRW 974
TGPW CS CG G ++R++ C++K G+ C HL +P + C+G C +W
Sbjct: 1446 STGPWSSCSVSCGRGHKQRNVYCMAKDGSHL---ESDYCKHLAKPHGHRKCRGGRC-PKW 1501
Query: 975 FSTPWSPCSRSCQGGTQTREVQC-LSTNQ-TLSTRCPPQLRPSRKRPCNSQPC 1025
+ WS CS SC G Q R V C + T++ T C P RP +R C C
Sbjct: 1502 KAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRC 1554
Score = 178 bits (452), Expect = 2e-44
Identities = 120/432 (27%), Positives = 182/432 (42%), Gaps = 73/432 (16%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W+ + CS SC G R +C++ + + LD+ C + + + C PCP W
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRN-DVLDDSKCTHQEK--VTIQRCSEFPCPQ-W 1056
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
++G+W+ C +CG G +HRQ+ C+ G + C +P Q+CQ C W+
Sbjct: 1057 KSGDWSECLVTCGKGHKHRQVWCQF----GEDRLNDRMCDPETKPTSMQTCQQPECASWQ 1112
Query: 788 VGSPWSQCSVRCGRGQRSRQVRCV-GNNGDEVSEQECASGPPQPPSREACDMGPC----- 841
G PW QCSV CG+G + R V+C+ G V + +C + +P + C++ C
Sbjct: 1113 AG-PWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC-NAATRPTDTQDCELPSCHPPPA 1170
Query: 842 ------------TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
T W W+ CSA CG G + R V C + E G+ +
Sbjct: 1171 APETRRSTYSAPRTQWRFGSWTP-CSATCGKGTRMRYVSC----------RDENGSVADE 1219
Query: 890 S-CPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICV---------S 939
S C T RP CS+ PC + W W CS CG G R ++CV S
Sbjct: 1220 SACATLPRPVAKEECSVTPCGQ---WKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRS 1276
Query: 940 KLGTEFNVTSPSNCSHLPRPP-------ALQPCQGQACQDR--------------WFSTP 978
+ ++ + +CS P P A P Q + + R W + P
Sbjct: 1277 ECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGP 1336
Query: 979 WSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQCKDSSP 1038
W CS +C GG+Q R V C N + C +++P +R C S PC Q + +
Sbjct: 1337 WGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTK 1396
Query: 1039 HCPLVVQARLCV 1050
C ++ RL V
Sbjct: 1397 LCGGGIRTRLVV 1408
Score = 35.8 bits (81), Expect = 0.22
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
+G WG W + +CS+ CG G++ R C P
Sbjct: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRP 618
Score = 31.6 bits (70), Expect = 4.2
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 7/53 (13%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP--RPPRHPEALLPRGQGPR 103
W+ CS CG GVQ+R CQ+ T ++ P RP + QGPR
Sbjct: 1506 WSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDC-----QGPR 1553
Score = 31.2 bits (69), Expect = 5.5
Identities = 12/19 (63%), Positives = 13/19 (68%)
Query: 53 WASCSQPCGVGVQRRSRTC 71
W SCS CGVGV +RS C
Sbjct: 1686 WGSCSVSCGVGVMQRSVQC 1704
Score = 30.8 bits (68), Expect = 7.2
Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 3/49 (6%)
Query: 34 QTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSL 82
Q E G P+ +G W C++ CG G++ R CQ + P L
Sbjct: 1375 QRACESGPCPQWAYG---NWGECTKLCGGGIRTRLVVCQRSNGERFPDL 1420
Score = 30.4 bits (67), Expect = 9.4
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 979 WSP---CSRSCQGGTQTREVQCLSTNQTLSTR-CPPQLRPSRKRPCNSQPCSQRP----D 1030
WSP CSR+C GG +T +C + C R + + CN++PC ++ D
Sbjct: 594 WSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVG--RRMKFKSCNTEPCLKQKRDFRD 651
Query: 1031 DQC 1033
+QC
Sbjct: 652 EQC 654
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 273 bits (699), Expect = 5e-73
Identities = 181/586 (30%), Positives = 258/586 (44%), Gaps = 100/586 (17%)
Query: 347 HASSLWSLFAP-------------------SSPIPRCSGESEQLRACSQAPCPPEQPDPR 387
H + WSL++P S C+G +Q R C PCP P R
Sbjct: 634 HLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFR 693
Query: 388 ALQCAAFNSQEFMGQ-LYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPG 446
QC A++ + + + QW+ + + + C L C P G + +EKV DGT C
Sbjct: 694 DWQCQAYSVRTSSPKHILQWQAVLDEE--KPCALFCSPVGKEQPILLSEKVMDGTSCGYQ 751
Query: 447 APDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWI 506
DIC GRC GCDG+LGS R D CGVC G+ +C+++ G+ G GY ++L I
Sbjct: 752 GLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRG-AGYVEVLVI 810
Query: 507 PAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGK 566
PAGA R+++ + +P+ +YLALR G +S IN +W ++ G++ GT Y R G
Sbjct: 811 PAGARRIKVVEEKPAHSYLALRDAGKQS-INSDWKIEHSGAFNLAGTTVHYVR----RGL 865
Query: 567 GESLSAEGPTTQPVD-VYMIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRV 625
E +SA+GPTT P+ + ++FQ++N G+ Y+Y I S P+ EN + + P
Sbjct: 866 WEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPS-DPLPENQSSKAP----------- 913
Query: 626 EPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVW 685
P W C A+CG G
Sbjct: 914 -------------------------------------EPLFMWTHTSWEDCDATCGGGER 936
Query: 686 RPIFLC--ISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGT 743
+ C I ++ +D C +P C+ PC W EWT CSR+CG G
Sbjct: 937 KTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGM 996
Query: 744 QHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-GHWEVGSPWSQCSVRCGRG 802
Q RQ+ C Q+ G ER P+P Q C+ + C WE G WS+CSV+CG+G
Sbjct: 997 QSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAG-VWSECSVKCGKG 1055
Query: 803 QRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGI 862
R R VRC ++C +P E C+ W DW SKCS CG G+
Sbjct: 1056 IRHRTVRCTN------PRKKCVLS-TRPREAEDCEDYSKCYVWRMGDW-SKCSITCGKGM 1107
Query: 863 QRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC 908
Q R + C+ + G C + +P R C L PC
Sbjct: 1108 QSRVIQCM----------HKITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 122 bits (305), Expect = 2e-27
Identities = 91/333 (27%), Positives = 133/333 (39%), Gaps = 44/333 (13%)
Query: 712 PASPEPCHGTPCPP----YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
P+ P P + + P W W C +CG G + + C + S V E+C
Sbjct: 900 PSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCK 959
Query: 768 HL--PRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVG--NNGDEVSEQEC 823
+L P P I + C + C + + W+ CS CG+G +SRQV C +NG + +E
Sbjct: 960 YLTKPEPQI-RKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARER 1018
Query: 824 ASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEA 883
P+P S + C+ C T W WS +CS +CG GI+ R+V C
Sbjct: 1019 DCIGPKPASAQRCEGQDCMTVWEAGVWS-ECSVKCGKGIRHRTVRC-------------- 1063
Query: 884 GAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGT 943
+ C +RP + C + + W G W +CS CG G Q R I C+ K+
Sbjct: 1064 -TNPRKKCVLSTRPREAEDCE--DYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG 1120
Query: 944 EFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQT 1003
+ C +P A +PC Q PC+ T T T +
Sbjct: 1121 RHG----NECFSSEKPAAYRPCHLQ------------PCNEKINVNTITSPRLAALTFKC 1164
Query: 1004 LSTRCPPQLRPSR-KRPCNSQPCSQRPDDQCKD 1035
L + P R R K C QR + C+D
Sbjct: 1165 LGDQWPVYCRVIREKNLCQDMRWYQRCCETCRD 1197
Score = 117 bits (294), Expect = 4e-26
Identities = 78/306 (25%), Positives = 118/306 (38%), Gaps = 45/306 (14%)
Query: 792 WSQCSVRCGRGQRSRQVRC---VGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
W C CG G+R V C + N V ++C P C+ PC T W +
Sbjct: 924 WEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMT 983
Query: 849 DWSSKCSAECGTGIQRRSVVC---LGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSL 905
+W+ CS CG G+Q R V C L +G + + + G +P + C
Sbjct: 984 EWTP-CSRTCGKGMQSRQVACTQQLSNGTLIRARERDC---------IGPKPASAQRCEG 1033
Query: 906 GPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSP-SNCSHLPRPPALQP 964
C W G W ECS +CG G + R + C T+P C RP +
Sbjct: 1034 QDCMTVWE--AGVWSECSVKCGKGIRHRTVRC----------TNPRKKCVLSTRPREAED 1081
Query: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCL-STNQTLSTRCPPQLRPSRKRPCNSQ 1023
C+ + W WS CS +C G Q+R +QC+ C +P+ RPC+ Q
Sbjct: 1082 CEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQ 1141
Query: 1024 PCSQRPDDQCKDSSP---------------HCPLVVQARLCVYPYYTATCCRSCAHVLER 1068
PC+++ + S +C ++ + LC + CC +C +
Sbjct: 1142 PCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQ 1201
Query: 1069 SPQDPS 1074
Q S
Sbjct: 1202 KLQQKS 1207
Score = 36.2 bits (82), Expect = 0.17
Identities = 13/35 (37%), Positives = 17/35 (48%)
Query: 37 TEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
T PE + G W W+ CS+ C G+ R R C
Sbjct: 626 TSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC 660
Score = 34.7 bits (78), Expect = 0.50
Identities = 16/47 (34%), Positives = 23/47 (48%), Gaps = 3/47 (6%)
Query: 979 WSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPC 1025
WSPCSR+C G +RE +C + P+ + R C + PC
Sbjct: 642 WSPCSRTCSAGISSRERKCPGLDSEARDCNGPR---KQYRICENPPC 685
Score = 31.2 bits (69), Expect = 5.5
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 39 EGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
EGQ VW V W+ CS CG G++ R+ C P
Sbjct: 1032 EGQDCMTVWEAGV-WSECSVKCGKGIRHRTVRCTNP 1066
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 270 bits (690), Expect = 5e-72
Identities = 183/577 (31%), Positives = 253/577 (43%), Gaps = 73/577 (12%)
Query: 304 SVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLW----------- 352
S+P G Q TG G + D G W + G SLW
Sbjct: 523 SIPAAEGTLCQ----TGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGV 578
Query: 353 --SLFAPSSPIPR-----CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQ 405
SL SP P C GE ++ R+C+ PCP D R QCA F++ F G+ Y
Sbjct: 579 SSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYN 638
Query: 406 WEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGIL 465
W+P+T G + C LNC G+ FY V DGT C + DIC+ G C GCD IL
Sbjct: 639 WKPYTG-GGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNIL 697
Query: 466 GSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYL 525
GS R D C VCGGD STC + G D GY +++ IP G++ +++ ++ S NY+
Sbjct: 698 GSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYI 757
Query: 526 ALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMI 585
AL+ G ING W +D P + GT F Y RP E ESL A GPT++ + V ++
Sbjct: 758 ALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEP---ESLEALGPTSENLIVMVL 814
Query: 586 FQEENPGVFYQYVISSPPPILENPTPEPPVP---QLQPEILRVEPPLAPAPRPARTPGTL 642
QE+N G+ Y++ + PI + + V QP + A G +
Sbjct: 815 LQEQNLGIRYKFNV----PITRTGSGDNEVGFTWNHQPW----------SECSATCAGGV 860
Query: 643 QRQVRI----------------PQMPAPPHPRTPLGSPA-AYWKRVGHSACSASCGKGVW 685
QRQ + P P + R P W CS +C G+
Sbjct: 861 QRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMR 920
Query: 686 RPIFLCISR---ESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPG 742
LCI + E LD C P EPC+ CPP W A +W+ C+ CGPG
Sbjct: 921 TRAVLCIRKIGPSEEETLDYSGCL--THRPVEKEPCNNQSCPPQWVALDWSECTPKCGPG 978
Query: 743 TQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC--GHWEVGSPWSQCSVRCG 800
+HR + C+ + P +C +P + C L C W G W QCS +CG
Sbjct: 979 FKHRIVLCKS--SDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGD-WGQCSAQCG 1035
Query: 801 RGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACD 837
GQ+ R V+C+ G + +C +PPS + C+
Sbjct: 1036 LGQQMRTVQCLSYTGQ--ASSDCLE-TVRPPSMQQCE 1069
Score = 148 bits (374), Expect = 2e-35
Identities = 87/280 (31%), Positives = 136/280 (48%), Gaps = 21/280 (7%)
Query: 791 PWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSRE-ACDMGPCTTAWFHSD 849
PWS+CS C G + ++V C + + + + +PP + AC+ PC WF D
Sbjct: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGD 907
Query: 850 WSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCE 909
W +CS C G++ R+V+C+ +GP + E +G C T RP + C+ C
Sbjct: 908 WL-ECSKTCDGGMRTRAVLCIRK---IGPSEEETLDYSG--CLT-HRPVEKEPCNNQSCP 960
Query: 910 RTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPS-NCSHLPRPPALQPCQ-G 967
+W W EC+ +CG G + R ++C S ++ + T P+ C +PP C G
Sbjct: 961 P--QWVALDWSECTPKCGPGFKHRIVLCKS---SDLSKTFPAAQCPEESKPPVRIRCSLG 1015
Query: 968 QACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
+ RW + W CS C G Q R VQCLS S+ C +RP + C S+ C
Sbjct: 1016 RCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESK-CDS 1074
Query: 1028 RP---DDQCKDSS--PHCPLVVQARLCVYPYYTATCCRSC 1062
P ++CKD + +CPLV++ + C Y+ CC++C
Sbjct: 1075 TPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
Score = 122 bits (307), Expect = 1e-27
Identities = 72/245 (29%), Positives = 105/245 (42%), Gaps = 14/245 (5%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W S CSA+C GV R +C + + C ++PP + C+ PCPP W
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
G+W CS++C G + R + C ++ G RP + C + C
Sbjct: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
Query: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC-TTAWF 846
V WS+C+ +CG G + R V C ++ + +PP R C +G C W
Sbjct: 964 VALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
Query: 847 HSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLG 906
DW +CSA+CG G Q R+V CL G+A + C RPP M+ C
Sbjct: 1024 TGDW-GQCSAQCGLGQQMRTVQCLSY-------TGQASS----DCLETVRPPSMQQCE-S 1070
Query: 907 PCERT 911
C+ T
Sbjct: 1071 KCDST 1075
Score = 83.2 bits (204), Expect = 1e-15
Identities = 43/126 (34%), Positives = 61/126 (48%), Gaps = 8/126 (6%)
Query: 906 GPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQ-P 964
G E + W PW ECS+ C G QR++++C K + ++ + C +PP Q
Sbjct: 836 GDNEVGFTWNHQPWSECSATCAGGVQRQEVVC--KRLDDNSIVQNNYCDPDSKPPENQRA 893
Query: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCL-----STNQTLSTRCPPQLRPSRKRP 1019
C + C WF W CS++C GG +TR V C+ S +TL RP K P
Sbjct: 894 CNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEP 953
Query: 1020 CNSQPC 1025
CN+Q C
Sbjct: 954 CNNQSC 959
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/34 (47%), Positives = 18/34 (52%)
Query: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Q +G WGPW W CS+ CG GV R C P
Sbjct: 555 QSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSP 588
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 263 bits (672), Expect = 7e-70
Identities = 165/485 (34%), Positives = 224/485 (46%), Gaps = 74/485 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C GE ++ R C+ CP +P R +QC+ F++ + GQL+ W P V CEL+CR
Sbjct: 577 CVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPV--VNDVNPCELHCR 634
Query: 424 PRGFRFYVRHTEKVQDGTLCQP--GAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
P F + + V DGT C + D+C+ G C + GCD + SG D CGVC G+
Sbjct: 635 PANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNG 694
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRS-IINGNW 540
STC VSG + G LGY + IPAGA ++I ++ ++N+LALR +NG W
Sbjct: 695 STCHTVSGTFEEAEG-LGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGW 753
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
+ G Y+ GT F Y R G E+L++ GPT +PV + ++FQE NPGV Y+Y
Sbjct: 754 TIQWNGDYQVAGTTFTYAR----RGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEY--- 806
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
T+ R+ A H P
Sbjct: 807 ----------------------------------------TIHRE-------AGGHDEVP 819
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
P W + C+ +CG+GV R C+ R++G +DE C RP C
Sbjct: 820 --PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP-VDEEHCDPLGRPDDQQRKCSE 876
Query: 721 TPCPPYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFG-GGGSSVPPERCGHLPRPNITQSC 778
PCP W AGEW CS SCGP G R + C + G S++ P C HLPRP C
Sbjct: 877 QPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPC 936
Query: 779 QLRL-C-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREAC 836
+ C W VG+ WSQCSV CG G + R V C + G E + QP S C
Sbjct: 937 NRHVPCPATWAVGN-WSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQ------QPASEVTC 989
Query: 837 DMGPC 841
+ C
Sbjct: 990 SLPLC 994
Score = 152 bits (384), Expect = 2e-36
Identities = 113/377 (29%), Positives = 146/377 (38%), Gaps = 55/377 (14%)
Query: 609 PTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQV-------------RIPQMPAPP 655
P P P+P+++ +EP P P PG+ Q + MP P
Sbjct: 1294 PPPIAPLPEMKVRDSSLEPGTPSFPTPG--PGSWDLQTVAVWGTFLPTTLTGLGHMPEPA 1351
Query: 656 HPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASP 715
P G P + V S S W S E A A PPA P
Sbjct: 1352 LNPGPKGQPESLSPEVPLS--SRLLSTPAWDSP--ANSHRVPETQPLAPSLAEAGPPADP 1407
Query: 716 EPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNIT 775
W+AG W+ CS +CG G R ++C SS E C RP
Sbjct: 1408 LVVRNAG----WQAGNWSECSTTCGLGAVWRPVRC--------SSGRDEDCAPAGRPQPA 1455
Query: 776 QSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG-DEVSEQECASGPPQPPSRE 834
+ C LR C W G+ WS+CS CG G R V+CV + C GP +PP+
Sbjct: 1456 RRCHLRPCATWHSGN-WSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHR 1514
Query: 835 ACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTG 894
C PC + W+ S W +CS CG G Q+R V C G C
Sbjct: 1515 PCGAQPCLS-WYTSSWR-ECSEACGGGEQQRLVTCPEPGL----------------CEEA 1556
Query: 895 SRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCS 954
RP R C+ PC + W GPWG+CS CG G QRR + CV+ T C
Sbjct: 1557 LRPNTTRPCNTHPCTQ---WVVGPWGQCSGPCGGGVQRRLVKCVN-TQTGLPEEDSDQCG 1612
Query: 955 HLPRPPALQPCQGQACQ 971
H P + +PC + C+
Sbjct: 1613 HEAWPESSRPCGTEDCE 1629
Score = 150 bits (379), Expect = 6e-36
Identities = 96/288 (33%), Positives = 125/288 (43%), Gaps = 43/288 (14%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECA-SGPPQPPSREACDMGPCTTA 844
W+ G+ WS+CS CG G R VRC +++CA +G PQP R C + PC T
Sbjct: 1415 WQAGN-WSECSTTCGLGAVWRPVRCSSGR-----DEDCAPAGRPQPARR--CHLRPCAT- 1465
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSG--AALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
W +WS KCS CG G R V C+ + L P + G ++PP R
Sbjct: 1466 WHSGNWS-KCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGP---------AKPPAHRP 1515
Query: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
C PC WYT W ECS CG G Q+R + C P C RP
Sbjct: 1516 CGAQPC---LSWYTSSWRECSEACGGGEQQRLVTC----------PEPGLCEEALRPNTT 1562
Query: 963 QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL----STRCPPQLRPSRKR 1018
+PC C +W PW CS C GG Q R V+C++T L S +C + P R
Sbjct: 1563 RPCNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSR 1621
Query: 1019 PCNSQPCSQRPDDQCKD---SSPHCPLVVQARLCVYPYYTATCCRSCA 1063
PC ++ C +C+ S C + C P CCRSC+
Sbjct: 1622 PCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCS 1669
Score = 118 bits (295), Expect = 3e-26
Identities = 77/228 (33%), Positives = 99/228 (43%), Gaps = 39/228 (17%)
Query: 825 SGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAG 884
+GPP P + W +WS +CS CG G R V C
Sbjct: 1401 AGPPADP------LVVRNAGWQAGNWS-ECSTTCGLGAVWRPVRC--------------S 1439
Query: 885 AGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTE 944
+G + C RP R C L PC W++G W +CS CG G+ RD+ CV +
Sbjct: 1440 SGRDEDCAPAGRPQPARRCHLRPCAT---WHSGNWSKCSRSCGGGSSVRDVQCVDT--RD 1494
Query: 945 FNVTSPSNCSHLP-RPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQT 1003
P +C P +PPA +PC Q C W+++ W CS +C GG Q R V C
Sbjct: 1495 LRPLRPFHCQPGPAKPPAHRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPEPG-- 1551
Query: 1004 LSTRCPPQLRPSRKRPCNSQPCSQ---RPDDQCKDSSPHCPLVVQARL 1048
C LRP+ RPCN+ PC+Q P QC S C VQ RL
Sbjct: 1552 ---LCEEALRPNTTRPCNTHPCTQWVVGPWGQC---SGPCGGGVQRRL 1593
Score = 116 bits (290), Expect = 1e-25
Identities = 69/193 (35%), Positives = 92/193 (47%), Gaps = 19/193 (9%)
Query: 837 DMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSR 896
++ P +W + W+ KC+ CG G+QR++V CL + +AG + C R
Sbjct: 817 EVPPPVFSWHYGPWT-KCTVTCGRGVQRQNVYCL---------ERQAGPVDEEHCDPLGR 866
Query: 897 PPDM-RACSLGPCERTWRWYTGPWGECSSECG-SGTQRRDIICVSKLGT-EFNVTSPSNC 953
P D R CS PC RW+ G W CSS CG G RR ++C+ +G E + P C
Sbjct: 867 PDDQQRKCSEQPCPA--RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPAC 924
Query: 954 SHLPRPPALQPCQGQA-CQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQL 1012
HLPRPP PC C W WS CS +C GTQ R V C TN T C
Sbjct: 925 EHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC--TNDT-GVPCDEAQ 981
Query: 1013 RPSRKRPCNSQPC 1025
+P+ + C+ C
Sbjct: 982 QPASEVTCSLPLC 994
Score = 105 bits (262), Expect = 2e-22
Identities = 64/192 (33%), Positives = 88/192 (45%), Gaps = 23/192 (11%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQEC-ASGPPQPPSREACDMGPCTTA 844
W G PW++C+V CGRG + + V C+ V E+ C G P R+ C PC
Sbjct: 825 WHYG-PWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRK-CSEQPCPAR 882
Query: 845 WFHSDWSSKCSAECGT-GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRAC 903
W+ +W CS+ CG G+ RR+V+C+ S G E A +C RPP C
Sbjct: 883 WWAGEW-QLCSSSCGPGGLSRRAVLCIRS-----VGLDEQSALEPPACEHLPRPPTETPC 936
Query: 904 SLG-PCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
+ PC TW G W +CS CG GTQRR+++C + G C +P +
Sbjct: 937 NRHVPCPATWA--VGNWSQCSVTCGEGTQRRNVLCTNDTGVP--------CDEAQQPASE 986
Query: 963 QPCQGQACQDRW 974
C C RW
Sbjct: 987 VTCSLPLC--RW 996
Score = 41.6 bits (96), Expect = 0.004
Identities = 15/32 (46%), Positives = 19/32 (59%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPT 75
+G W W W+ CS+ CG+GVQ R C PT
Sbjct: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPT 569
Score = 36.6 bits (83), Expect = 0.13
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 2/63 (3%)
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESG-EELDERSCAAGARPPASPEPCHGTP 722
P W CS CG GV R + C++ ++G E D C A P +S PC
Sbjct: 1569 PCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS-RPCGTED 1627
Query: 723 CPP 725
C P
Sbjct: 1628 CEP 1630
Score = 35.0 bits (79), Expect = 0.38
Identities = 31/93 (33%), Positives = 36/93 (38%), Gaps = 29/93 (31%)
Query: 668 WKRVG---HSACSAS-----CGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCH 719
W VG HS A+ CG+ W C+S E G RP A
Sbjct: 496 WCSVGTTCHSKLDAAVDGTRCGENKW-----CLSGEC--------VPVGFRPEAVDGGWS 542
Query: 720 GTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ 752
G W A W+ CSRSCG G Q + QC Q
Sbjct: 543 G------WSA--WSICSRSCGMGVQSAERQCTQ 567
Score = 33.9 bits (76), Expect = 0.85
Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 4/57 (7%)
Query: 15 LLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
L++ P+ L +E L ++ + P + V GPW Q CS PCG GVQRR C
Sbjct: 1544 LVTCPEPGLCEEALRPNTTR-PCNTHPCTQWVVGPWGQ---CSGPCGGGVQRRLVKC 1596
Score = 33.5 bits (75), Expect = 1.1
Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 3/48 (6%)
Query: 979 WSPCSRSCQGGTQTREVQCLSTNQTLSTR-CPPQLRPSRKRPCNSQPC 1025
WS CSRSC G Q+ E QC R C + + R R CN Q C
Sbjct: 547 WSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERK--RFRLCNLQAC 592
Score = 30.4 bits (67), Expect = 9.4
Identities = 19/51 (37%), Positives = 23/51 (45%), Gaps = 2/51 (3%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRP-PRHPEALLPRGQGP 102
W+ CS+ CG G R C + T L P P +P P P A P G P
Sbjct: 1471 WSKCSRSCGGGSSVRDVQC-VDTRDLRPLRPFHCQPGPAKPPAHRPCGAQP 1520
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 261 bits (668), Expect = 2e-69
Identities = 165/492 (33%), Positives = 228/492 (46%), Gaps = 41/492 (8%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C GE + R+C+ CPP D R +QC+ F+S F G+ Y+W+ + G + C L C
Sbjct: 586 CLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRG-GGVKACSLTCL 644
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
GF FY V DGT C+P DICV+G C GCD +LGS R D C VCGGD S
Sbjct: 645 AEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSA 704
Query: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
C + G + GY+ ++WIP G++ + I L S ++LAL+G ++ G
Sbjct: 705 CETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTP 764
Query: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQY----VI 599
P GT F+ + P + +SL A GP + V ++ + E P + Y++
Sbjct: 765 QPHRLPLAGTTFQLRQGPDQV---QSLEALGPINASLIVMVLARTELPALRYRFNAPIAR 821
Query: 600 SSPPPILENPTPEPPV-------PQLQPEILRVE-PPLAPAPRPARTPGTL-QRQVRIPQ 650
S PP + P Q+Q R + A AP L +RQ
Sbjct: 822 DSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNT 881
Query: 651 MPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEE---LDERSCAA 707
P PP W S CS SC GV +C R S E LD+ +C
Sbjct: 882 EPCPPD-----------WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ 930
Query: 708 GARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
RPP E CHG CPP W A +W+ C+ SCGPG +HR + C+ +++PP C
Sbjct: 931 -PRPPVL-EACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKS--ADHRATLPPAHCS 986
Query: 768 HLPRPNITQSCQLRLC--GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECAS 825
+P T C LR C W G W +CS +CG GQR R VRC + G + EC
Sbjct: 987 PAAKPPATMRCNLRRCPPARWVAGE-WGECSAQCGVGQRQRSVRCTSHTGQ--ASHECTE 1043
Query: 826 GPPQPPSREACD 837
+PP+ + C+
Sbjct: 1044 A-LRPPTTQQCE 1054
Score = 154 bits (388), Expect = 6e-37
Identities = 88/280 (31%), Positives = 129/280 (46%), Gaps = 18/280 (6%)
Query: 790 SPWSQCSVRCGRGQRSRQVRCVGN-NGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
+PW++CS +C G + + V C + V+ C++ P + AC+ PC W
Sbjct: 832 APWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVG 891
Query: 849 DWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC 908
+WS CS C G++ RSVVC +A E A +CP RPP + AC C
Sbjct: 892 NWSL-CSRSCDAGVRSRSVVCQRRVSA-----AEEKALDDSACPQ-PRPPVLEACHGPTC 944
Query: 909 ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQ 968
W W EC+ CG G + R ++C K P++CS +PPA C +
Sbjct: 945 PPEWAALD--WSECTPSCGPGLRHRVVLC--KSADHRATLPPAHCSPAAKPPATMRCNLR 1000
Query: 969 ACQD-RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
C RW + W CS C G + R V+C S S C LRP + C ++ S
Sbjct: 1001 RCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSP 1060
Query: 1028 RPDD---QCKDSS--PHCPLVVQARLCVYPYYTATCCRSC 1062
P D +CKD + +CPLV++ + C Y+ CC++C
Sbjct: 1061 TPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
Score = 116 bits (291), Expect = 1e-25
Identities = 67/241 (27%), Positives = 98/241 (40%), Gaps = 13/241 (5%)
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
P W + CSA C G C ++ + C+A ++ P C+ PC
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 724 PPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
PP W G W+ CSRSC G + R + C++ + PRP + ++C C
Sbjct: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTC 944
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTT 843
WS+C+ CG G R R V C + S +PP+ C++ C
Sbjct: 945 PPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004
Query: 844 A-WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
A W +W +CSA+CG G ++RSV C G+A C RPP +
Sbjct: 1005 ARWVAGEW-GECSAQCGVGQRQRSVRCTSH-------TGQA----SHECTEALRPPTTQQ 1052
Query: 903 C 903
C
Sbjct: 1053 C 1053
Score = 70.9 bits (172), Expect = 6e-12
Identities = 36/120 (30%), Positives = 56/120 (46%), Gaps = 8/120 (6%)
Query: 912 WRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCS-HLPRPPALQPCQGQAC 970
+ W+ PW +CS++C G+Q + + C ++L + + +P CS H P + C + C
Sbjct: 827 YSWHYAPWTKCSAQCAGGSQVQAVECRNQL--DSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 971 QDRWFSTPWSPCSRSCQGGTQTREVQC-----LSTNQTLSTRCPPQLRPSRKRPCNSQPC 1025
W WS CSRSC G ++R V C + + L PQ RP C+ C
Sbjct: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTC 944
Score = 48.1 bits (113), Expect = 4e-05
Identities = 17/34 (50%), Positives = 20/34 (58%)
Query: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
+G +G WGPW W CS+ CG GV SR C P
Sbjct: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSP 577
Score = 38.9 bits (89), Expect = 0.026
Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 7/64 (10%)
Query: 977 TPWSPCSRSCQGGTQTREVQCLSTNQTLSTR-CPPQLRPSRKRPCNSQPCSQRPDD---- 1031
TPW CSR+C GG + C S T+ + C + R R R CN+ C D
Sbjct: 554 TPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERR--RHRSCNTDDCPPGSQDFREV 611
Query: 1032 QCKD 1035
QC +
Sbjct: 612 QCSE 615
Score = 33.9 bits (76), Expect = 0.85
Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 3/62 (4%)
Query: 50 WV--QWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTS 107
WV +W CS CGVG ++RS C T Q RPP + + P P
Sbjct: 1007 WVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPT-TQQCEAKCDSPTPGDG 1065
Query: 108 PE 109
PE
Sbjct: 1066 PE 1067
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/107 (29%), Positives = 41/107 (38%), Gaps = 32/107 (29%)
Query: 892 PTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPS 951
P GSRP + + W +T PWG+CS CG G V+S S
Sbjct: 538 PFGSRPEGV--------DGAWGPWT-PWGDCSRTCGGG-----------------VSSSS 571
Query: 952 NCSHLPRPP-ALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQC 997
PRP + C G+ + R +T P G REVQC
Sbjct: 572 RHCDSPRPTIGGKYCLGERRRHRSCNTDDCP-----PGSQDFREVQC 613
Score = 30.4 bits (67), Expect = 9.4
Identities = 22/68 (32%), Positives = 26/68 (38%), Gaps = 7/68 (10%)
Query: 29 SGHSLQTPTEEGQGPEGVWGPWV--QWASCSQPCGVGVQRRSRTCQ-----LPTVQLHPS 81
S HS + E WV W+ CS+ C GV+ RS CQ L S
Sbjct: 867 SAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDS 926
Query: 82 LPLPPRPP 89
PRPP
Sbjct: 927 ACPQPRPP 934
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 257 bits (657), Expect = 4e-68
Identities = 213/763 (27%), Positives = 300/763 (39%), Gaps = 133/763 (17%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G + + R CS CPPE D RA QC+A N + GQ Y+W P + C L C+
Sbjct: 66 CEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQ 124
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
+G V KV DGT C + D+C++G C GCD LGS + D CGVC GD ST
Sbjct: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
Query: 484 CRLVSGNLTDR-GGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
CRLV G + ++ IP G+ +++ P YL + G G ++
Sbjct: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSL 241
Query: 543 DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPG--------VF 594
G++ + + + P + E L GP T I + N G +F
Sbjct: 242 SSTGTFLVDNSSVDFQKFPDK----EILRMAGPLTAD----FIVKIRNSGSADSTVQFIF 293
Query: 595 YQYVI-----------------------SSPPPILENPTPEPPVPQLQPEILRVEPPLAP 631
YQ +I + + N PE ++ +P L
Sbjct: 294 YQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
Query: 632 APRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLC 691
+Q+ +P P PR W+ +ACS+SCG G+ C
Sbjct: 354 CNLDPCPASDGYKQI-MPYDLYHPLPR---------WEATPWTACSSSCGGGIQSRAVSC 403
Query: 692 ISRE---SGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQL 748
+ + ++E C + P + +PC+ CP W A EW+ C+ +CG G ++R +
Sbjct: 404 VEEDIQGHVTSVEEWKCMYTPKMPIA-QPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVV 461
Query: 749 QCRQEFG--GGGSS-----------VPPERCGHLPRPNITQSCQL---RLCGHWEVGS-- 790
C G GG S + P C + P+ + +L + E G+
Sbjct: 462 LCIDHRGMHTGGCSPKTKPHIKEECIVPTPC-YKPKEKLPVEAKLPWFKQAQELEEGAAV 520
Query: 791 ---------PWSQCSVRCGRGQRSRQVRC-----VGNNGDEVSEQECASGPPQPPSREAC 836
WS C+V CG G + R VRC + ++ EC P+P S+ AC
Sbjct: 521 SEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEG--PKPASQRAC 578
Query: 837 DMGPC-----------TTAWFHS--------DWS----SKCSAECGTGIQRRSVVCLGSG 873
GPC T F DW +KCS CG G+Q V CL
Sbjct: 579 YAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK- 637
Query: 874 AALGPGQGEAGAGTGQSCPTGSRPPD-MRACSLGPCERTWRWYTGPWGECSSECGSGTQR 932
P + C T RPP +++C+L PC RW G W CS CG G Q
Sbjct: 638 QTREPAEENL-------CVTSRRPPQLLKSCNLDPCPA--RWEIGKWSPCSLTCGVGLQT 688
Query: 933 RDIICVSKLGTEFN--VTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGT 990
RD+ C L E N V P+P +Q C C W+ W PCSR+C GG
Sbjct: 689 RDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGV 748
Query: 991 QTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQC 1033
Q REV C S P+ S +P Q C + D C
Sbjct: 749 QKREVLCKQRMADGSFLELPETFCSASKPACQQACKK---DDC 788
Score = 154 bits (389), Expect = 4e-37
Identities = 118/460 (25%), Positives = 177/460 (38%), Gaps = 85/460 (18%)
Query: 657 PRTPLGSPAAY-----WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARP 711
P+ P+ P W S C+ +CG+G+ + LCI + C+ +P
Sbjct: 424 PKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG---MHTGGCSPKTKP 480
Query: 712 PASPEPCHGTPC-------------PPYWEAGE-----------------WTSCSRSCGP 741
E TPC P + +A E W++C+ +CG
Sbjct: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
Query: 742 GTQHRQLQCRQ--EFGGGGSSVPPERCGHLPRPNITQSCQLRLCG--------------- 784
GTQ R ++C+ F + +P + C P+P ++C C
Sbjct: 541 GTQVRIVRCQVLLSFSQSVADLPIDECEG-PKPASQRACYAGPCSGEIPEFNPDETDGLF 599
Query: 785 ----------HWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE-CASGPPQPPSR 833
WE +++CS CG G + V C+ E +E+ C + P
Sbjct: 600 GGLQDFDELYDWEYEG-FTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLL 658
Query: 834 EACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPT 893
++C++ PC W WS CS CG G+Q R V C L E + C
Sbjct: 659 KSCNLDPCPARWEIGKWSP-CSLTCGVGLQTRDVFC---SHLLSREMNETVILADELCRQ 714
Query: 894 GSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNC 953
+P ++AC+ C W Y W CS CG G Q+R+++C ++ + P
Sbjct: 715 -PKPSTVQACNRFNCPPAW--YPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETF 771
Query: 954 SHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQT------LSTR 1007
+P Q C+ C W + W+ CS SC GTQTR C +T ST
Sbjct: 772 CSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTL 831
Query: 1008 CPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQAR 1047
CPP S RPC C+ RP + S+ H P + AR
Sbjct: 832 CPPLPFSSSIRPCMLATCA-RPG---RPSTKHSPHIAAAR 867
Score = 134 bits (336), Expect = 6e-31
Identities = 89/299 (29%), Positives = 138/299 (46%), Gaps = 27/299 (9%)
Query: 774 ITQSCQLRLCGHWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
+ Q L + +W + CS CG RG + ++RC+ N+ EV+ CA
Sbjct: 1478 LMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNS-TEVNPAHCAGKVRPAVQ 1536
Query: 833 REACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCP 892
AC+ C + W + WS+ C+ CG G+Q R V C A+ G + + C
Sbjct: 1537 PIACNRRDCPSRWMVTSWSA-CTRSCGGGVQTRRVTCQKLKAS-----GISTPVSNDMCT 1590
Query: 893 -TGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGS---GTQRRDIICVSKLGTEFNVT 948
RP D +AC+ C W WG+C+ C Q R + C ++ G +T
Sbjct: 1591 QVAKRPVDTQACNQQLCVE---WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDG----IT 1643
Query: 949 SPSN-CSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQG-GTQTREVQCL--STNQTL 1004
PS CS LPRP + Q C +AC W + W+ C+ +C G Q+R V+C+ TN+ +
Sbjct: 1644 LPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAV 1703
Query: 1005 STR-CPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
C RP+ + CN PC +C+D++ +C V Q +LC + + CC +C
Sbjct: 1704 PEHLCSWGPRPANWQRCNITPCENM---ECRDTTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 125 bits (313), Expect = 3e-28
Identities = 83/251 (33%), Positives = 120/251 (47%), Gaps = 21/251 (8%)
Query: 667 YWKRVGHSA-CSASCG-KGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP 724
YW V A CSASCG +GV +P C+ + E++ CA RP P C+ CP
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNST--EVNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 725 PYWEAGEWTSCSRSCGPGTQHRQLQCRQ-EFGGGGSSVPPERCGHL-PRPNITQSCQLRL 782
W W++C+RSCG G Q R++ C++ + G + V + C + RP TQ+C +L
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 783 CGHWEVGSPWSQCSVRC---GRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
C W S W QC+ C + RQV C +G + ++C S P+P S + C
Sbjct: 1607 CVEWAFSS-WGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQC-SALPRPVSTQNCWSE 1664
Query: 840 PCTTAWFHSDWSSKCSAECGT-GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPP 898
C+ W S W + C+A CG G Q R V C+ + A C G RP
Sbjct: 1665 ACSVHWRVSLW-TLCTATCGNYGFQSRRVECVHART--------NKAVPEHLCSWGPRPA 1715
Query: 899 DMRACSLGPCE 909
+ + C++ PCE
Sbjct: 1716 NWQRCNITPCE 1726
Score = 50.8 bits (120), Expect = 7e-06
Identities = 34/111 (30%), Positives = 48/111 (43%), Gaps = 6/111 (5%)
Query: 686 RPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGP-GTQ 744
R +F C +R+ G L C+A RP S + C C +W WT C+ +CG G Q
Sbjct: 1632 RQVF-CQTRD-GITLPSEQCSALPRP-VSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQ 1688
Query: 745 HRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQC 795
R+++C +VP C PRP Q C + C + E C
Sbjct: 1689 SRRVECVH--ARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYC 1737
Score = 42.7 bits (99), Expect = 0.002
Identities = 75/342 (21%), Positives = 123/342 (35%), Gaps = 61/342 (17%)
Query: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-G 784
W+A G W+ CSR+CG G + +C G ++ C ++ P + + C
Sbjct: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
Query: 785 HWEV-------------GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
H +V P + CS++C + V E++ +
Sbjct: 96 HNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVV--------ELAPKVLDGTRCYTE 147
Query: 832 SREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSV-VCLGSGAA--LGPGQGEAGAGTG 888
S + C G C C + G+ ++ + VC G G+ L GQ ++
Sbjct: 148 SLDMCISGLCQIV--------GCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
Query: 889 QS------CPTGSRPPDMRACSLGPCERTWRWYT--GPWGECS-SECGSGTQRRDIICVS 939
+S P GSR +R GP T G GE S S G+ +
Sbjct: 200 KSDDTVVAIPYGSR--HIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQ 257
Query: 940 KLGTE--FNVTSPSNCSHLPR-------PPALQPCQGQACQDRWFSTPWSPCSRSCQGGT 990
K + + P + + +Q Q RW T + PCS +C GG
Sbjct: 258 KFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGY 317
Query: 991 QTREVQC--LSTNQTLSTR----CPPQLRPSRK-RPCNSQPC 1025
Q +C L +N+ ++ + P ++P K + CN PC
Sbjct: 318 QLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Score = 33.9 bits (76), Expect = 0.85
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTC 71
+G+W W W+ CS+ CG G R C
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRC 60
Score = 33.1 bits (74), Expect = 1.4
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE 817
G W+ PWS+CS CG G RC+ + E
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
Score = 31.6 bits (70), Expect = 4.2
Identities = 13/26 (50%), Positives = 16/26 (61%), Gaps = 1/26 (3%)
Query: 47 WGPWVQWASCSQPCGVGVQRRSRTCQ 72
W P QW CS+ CG GVQ+R C+
Sbjct: 732 WYP-AQWQPCSRTCGGGVQKREVLCK 756
Score = 31.2 bits (69), Expect = 5.5
Identities = 11/20 (55%), Positives = 15/20 (75%)
Query: 53 WASCSQPCGVGVQRRSRTCQ 72
W++C++ CG GVQ R TCQ
Sbjct: 1554 WSACTRSCGGGVQTRRVTCQ 1573
Score = 30.4 bits (67), Expect = 9.4
Identities = 11/27 (40%), Positives = 16/27 (59%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLH 79
W +CS CG G+Q R+ +C +Q H
Sbjct: 385 WTACSSSCGGGIQSRAVSCVEEDIQGH 411
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 235 bits (600), Expect = 1e-61
Identities = 171/553 (30%), Positives = 225/553 (40%), Gaps = 113/553 (20%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G + R+C CP D RA QCA F+ EF G+ Y+W P+ +CELNC
Sbjct: 64 CVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPY--YSAPNKCELNCI 121
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
P+G FY +H E V DGT C+PG D+CV G C GCD L S ++ D C CGGD +T
Sbjct: 122 PKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT 181
Query: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
C V+G A L + +R G +NG+W ++
Sbjct: 182 CYPVAGTFD---------------ANDLSRAVKNVR------------GEYYLNGHWTIE 214
Query: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPP 603
+ A T+ Y R + E L A GPT++ P
Sbjct: 215 AARALPAASTILHYERGAEGDLAPERLHARGPTSE------------------------P 250
Query: 604 PILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGS 663
++E + EP PG + + +P R P S
Sbjct: 251 LVIELISQEP------------------------NPG-VHYEYHLPL-------RRP--S 276
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
P W S CSA CG G + C E + C RP A C+ PC
Sbjct: 277 PGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH--EAYPDHMCQRQPRP-ADRRSCNLHPC 333
Query: 724 PPY--WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERCGHLP-RPNITQSCQ 779
P W+AG W CS SCG G+Q R + C G G +V C LP +P Q+C
Sbjct: 334 PETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACN 393
Query: 780 LRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
L+ C W PW +CSV CG G R R V C G G + C S +PP E C
Sbjct: 394 LQRCAAWS-PEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAAC-SLEDRPPLTEPCVHE 451
Query: 840 PC----TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGS 895
C AW W CS C +G +RR V+C A+GP + G+ Q S
Sbjct: 452 DCPLLSDQAWHVGTW-GLCSKSCSSGTRRRQVIC-----AIGP---PSHCGSLQH----S 498
Query: 896 RPPDMRACSLGPC 908
+P D+ C+ PC
Sbjct: 499 KPVDVEPCNTQPC 511
Score = 155 bits (391), Expect = 3e-37
Identities = 90/261 (34%), Positives = 122/261 (46%), Gaps = 36/261 (13%)
Query: 722 PCPPY-WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
P P + W G W+ CS CG G Q R + C + + P C PRP +SC L
Sbjct: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH----EAYPDHMCQRQPRPADRRSCNL 330
Query: 781 RLCGH---WEVGSPWSQCSVRCGRGQRSRQVRCVGNNG----DEVSEQECASGPPQPPSR 833
C W+ G PW+ CS CG G +SR V C+ ++G + V E ECA P +PP+
Sbjct: 331 HPCPETKRWKAG-PWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAI 389
Query: 834 EACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPT 893
+AC++ C AW W +CS CG G+++RSV C G +L +C
Sbjct: 390 QACNLQRCA-AWSPEPWG-ECSVSCGVGVRKRSVTCRGERGSLLHTA---------ACSL 438
Query: 894 GSRPPDMRACSLGPCE--RTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPS 951
RPP C C W+ G WG CS C SGT+RR +IC + PS
Sbjct: 439 EDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICA--------IGPPS 490
Query: 952 NCSHL--PRPPALQPCQGQAC 970
+C L +P ++PC Q C
Sbjct: 491 HCGSLQHSKPVDVEPCNTQPC 511
Score = 141 bits (355), Expect = 4e-33
Identities = 85/247 (34%), Positives = 115/247 (46%), Gaps = 23/247 (9%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC--TT 843
W GS WS CS CG G +SR V C ++ E P+P R +C++ PC T
Sbjct: 281 WSHGS-WSDCSAECGGGHQSRLVFCTIDH--EAYPDHMCQRQPRPADRRSCNLHPCPETK 337
Query: 844 AWFHSDWSSKCSAECGTGIQRRSVVCLGS-GAALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
W W+ CSA CG G Q RSV C+ S GA + EA + +PP ++A
Sbjct: 338 RWKAGPWAP-CSASCGGGSQSRSVYCISSDGAGIQEAVEEA-----ECAGLPGKPPAIQA 391
Query: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
C+L C W PWGECS CG G ++R + C + G+ + + CS RPP
Sbjct: 392 CNLQRCAA---WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAA---CSLEDRPPLT 445
Query: 963 QPCQGQAC----QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKR 1018
+PC + C W W CS+SC GT+ R+V C + +P
Sbjct: 446 EPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVIC-AIGPPSHCGSLQHSKPVDVE 504
Query: 1019 PCNSQPC 1025
PCN+QPC
Sbjct: 505 PCNTQPC 511
Score = 125 bits (314), Expect = 2e-28
Identities = 69/186 (37%), Positives = 85/186 (45%), Gaps = 16/186 (8%)
Query: 844 AWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRAC 903
+W H WS CSAECG G Q R V C A C RP D R+C
Sbjct: 280 SWSHGSWSD-CSAECGGGHQSRLVFCTIDHEAY----------PDHMCQRQPRPADRRSC 328
Query: 904 SLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEF-NVTSPSNCSHLP-RPPA 961
+L PC T RW GPW CS+ CG G+Q R + C+S G + C+ LP +PPA
Sbjct: 329 NLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPA 388
Query: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL--STRCPPQLRPSRKRP 1019
+Q C Q C W PW CS SC G + R V C +L + C + RP P
Sbjct: 389 IQACNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEP 447
Query: 1020 CNSQPC 1025
C + C
Sbjct: 448 CVHEDC 453
Score = 58.2 bits (139), Expect = 4e-08
Identities = 80/324 (24%), Positives = 112/324 (34%), Gaps = 49/324 (15%)
Query: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGS 790
+W+ CSR+CG G R+ C + GGSS H +SC+ C
Sbjct: 34 QWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSH-------RSCRTESCPDGARDF 86
Query: 791 PWSQCSVRCG---RGQRSR-----------QVRCV--GNNGDEVSEQECASGPP-QPPSR 833
QC+ G +G+R R ++ C+ G N + G P +P R
Sbjct: 87 RAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGKR 146
Query: 834 EACDMGPCTTAWF-HSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCP 892
+ C G C H SSK +C + C G G P G A
Sbjct: 147 DVCVDGSCRVVGCDHELDSSKQEDKC--------LRCGGDGTTCYPVAGTFDANDLSRAV 198
Query: 893 TGSRPP-------DMRACSLGPCERTWRWYT-GPWGECSSECGSGTQRRDIICVSKLGTE 944
R + A P T Y G G+ + E V +L ++
Sbjct: 199 KNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQ 258
Query: 945 FNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL 1004
HLP +P G + W WS CS C GG Q+R V C ++
Sbjct: 259 EPNPGVHYEYHLP---LRRPSPGFS----WSHGSWSDCSAECGGGHQSRLVFCTIDHEAY 311
Query: 1005 STR-CPPQLRPSRKRPCNSQPCSQ 1027
C Q RP+ +R CN PC +
Sbjct: 312 PDHMCQRQPRPADRRSCNLHPCPE 335
Score = 42.7 bits (99), Expect = 0.002
Identities = 15/25 (60%), Positives = 17/25 (68%)
Query: 47 WGPWVQWASCSQPCGVGVQRRSRTC 71
WGPW QW+ CS+ CG GV R R C
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPC 53
Score = 40.0 bits (92), Expect = 0.012
Identities = 25/75 (33%), Positives = 34/75 (45%), Gaps = 11/75 (14%)
Query: 959 PPALQPCQGQAC------QDRWFS-TPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQ 1011
P L P G + D W + WSPCSR+C GG RE C S + + C
Sbjct: 8 PLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSC--- 64
Query: 1012 LRPSRK-RPCNSQPC 1025
+ P+R R C ++ C
Sbjct: 65 VGPARSHRSCRTESC 79
Score = 36.2 bits (82), Expect = 0.17
Identities = 23/77 (29%), Positives = 35/77 (45%), Gaps = 18/77 (23%)
Query: 987 QGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCPLVVQA 1046
Q +++ EV+ +S T R P R C QP +C L++QA
Sbjct: 1182 QAVSRSTEVKVVSPAPTAQPRDPG-------RDCVDQP-----------ELANCDLILQA 1223
Query: 1047 RLCVYPYYTATCCRSCA 1063
+LC YY++ CC SC+
Sbjct: 1224 QLCGNEYYSSFCCASCS 1240
Score = 35.8 bits (81), Expect = 0.22
Identities = 64/239 (26%), Positives = 88/239 (36%), Gaps = 33/239 (13%)
Query: 47 WGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL--HPSLPLPPRPPR-----HPEALLPRG 99
W P W CS CGVGV++RS TC+ L + L RPP H + L
Sbjct: 400 WSP-EPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSD 458
Query: 100 QGPRPQTSPETLPLYRTQSRGRGGPLR-GPASHLGREETQEIRAARRSRLRDPIKPGMFG 158
Q T + +R R GP SH G + + S+ D ++P
Sbjct: 459 QAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCG--------SLQHSKPVD-VEPCNTQ 509
Query: 159 YGRVPFALPLHRNRRHPRSPP-----RSELSLISSRGE--EAIPSPTPRAEPFSANGSPQ 211
+P +P ++ P S P E SRG+ A P+ R + G P+
Sbjct: 510 PCHLPQEVPSMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGDHRGERGDPR 569
Query: 212 TELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPPSPTHSLG 270
+ T LS P+P L Q + + P RH P G P T SLG
Sbjct: 570 GD-QGTHLSALGPAPS---LQQPPYQQPLRSGSGPHDCRHSPH----GCCPDGHTASLG 620
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 225 bits (573), Expect = 2e-58
Identities = 130/403 (32%), Positives = 190/403 (47%), Gaps = 32/403 (7%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
Query: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 687 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 737
Query: 842 TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMR 901
W SDW CS CG G R V C S + P C ++P +
Sbjct: 738 DRQWTVSDW-GPCSGSCGQGRTIRHVYCKTSDGRVVP---------ESQCQMETKPLAIH 787
Query: 902 ACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
C C W W C++ CG G ++R ++C+ + S C +PP
Sbjct: 788 PCGDKNCPA--HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPE 845
Query: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCN 1021
C + C +W+++PWS C+++C G + R+V+C + C P ++P ++ C+
Sbjct: 846 ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACD 903
Query: 1022 SQPC-SQRPDDQCKDS-SPHCPLVVQARLCVYPYYTATCCRSC 1062
QPC ++ PDD C+D +C L ++ LC + YY+ CCRSC
Sbjct: 904 LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
Score = 152 bits (384), Expect = 2e-36
Identities = 86/247 (34%), Positives = 131/247 (53%), Gaps = 9/247 (3%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQ----GSQRCE 419
C+G S++ + C CPP+ R QC +FNS + G+ +QW+P S+ C+
Sbjct: 90 CTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCD 149
Query: 420 LNCRPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
L+C + + +DGT C+ +CV+G+C GCDG+L S D CG+C
Sbjct: 150 LHCTTVDGQRQLM--VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQ 207
Query: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIING 538
GD S+C V+GN LGY + IPAGA +QI + + S++ LAL G NG
Sbjct: 208 GDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNG 267
Query: 539 NWAVDPPGSYRAGGTVFRYNRPPREEGKG-ESLSAEGPTTQPVDVYMIFQE-ENPGVFYQ 596
N+ VD P ++ GTV +Y RP G E + A+GPT Q ++V + Q ++P + ++
Sbjct: 268 NYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFE 327
Query: 597 YVISSPP 603
Y + PP
Sbjct: 328 YTLLQPP 334
Score = 66.2 bits (160), Expect = 2e-10
Identities = 42/137 (30%), Positives = 59/137 (43%), Gaps = 13/137 (9%)
Query: 898 PDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLP 957
P R + P + +RW CS+ C +G +CV G E S C L
Sbjct: 553 PKARKQGVSPADM-YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALT 608
Query: 958 RP-PALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLS------TNQTLSTRC-- 1008
RP P + C G+ CQ RW ++ WS CSR+C G Q R V+C + S C
Sbjct: 609 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
Query: 1009 PPQLRPSRKRPCNSQPC 1025
+RP ++ C + C
Sbjct: 669 AEAVRPEERKTCRNPAC 685
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 774 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 832
Query: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 833 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
Query: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
+ + P + C P N + ++ LCGHW
Sbjct: 892 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
Score = 40.8 bits (94), Expect = 0.007
Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 8/73 (10%)
Query: 4 WTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQ--GPEGV---WGPWVQWASCSQ 58
W W + LL+L++ V +G + +PT G + WG W +W +CS+
Sbjct: 5 WQCSCWAWFLLVLAV---VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSR 61
Query: 59 PCGVGVQRRSRTC 71
CG GV + R C
Sbjct: 62 SCGGGVTSQERHC 74
Score = 38.9 bits (89), Expect = 0.026
Identities = 35/119 (29%), Positives = 44/119 (36%), Gaps = 35/119 (29%)
Query: 977 TPWSPCSRSCQGGTQTREVQCLST---------NQTLS-----------TRCPPQLRPSR 1016
T W+ CSRSC GG ++E CL N+T + CPP R R
Sbjct: 54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFR 113
Query: 1017 KRPC---NSQPCSQR--------PDDQCKDSSP----HCPLVVQARLCVYPYYTATCCR 1060
+ C NS + R PDD SS HC V R + P T C+
Sbjct: 114 EEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCK 172
Score = 36.2 bits (82), Expect = 0.17
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 701 DERSCAAGARPPASPEPCHGTPCPPYW--EAGEWTSCSRSCGPGTQHRQLQCRQE 753
D S + P S GT +W E +WT+CSRSCG G ++ C Q+
Sbjct: 23 DTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
Score = 35.0 bits (79), Expect = 0.38
Identities = 48/197 (24%), Positives = 70/197 (35%), Gaps = 33/197 (16%)
Query: 815 GDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWS--SKCSAECGTGIQRRSVVCLGS 872
GD VS P+ + + G TA++ +W+ + CS CG G+ + CL
Sbjct: 22 GDTVS----TGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
Query: 873 GAALGPGQG-EAGAGTG---QSCPTGSRPPDMRACSLGPC---------ERTWRW---YT 916
PG G GT Q C PPD R+ C RT +W Y
Sbjct: 78 RRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYP 137
Query: 917 GPWGECSSE-----CGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQ 971
+ SS+ C + +R ++ ++ GT +T L C+ C
Sbjct: 138 DDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTD------LRGVCVSGKCEPIGCD 191
Query: 972 DRWFSTPWSPCSRSCQG 988
FST CQG
Sbjct: 192 GVLFSTHTLDKCGICQG 208
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 225 bits (573), Expect = 2e-58
Identities = 130/403 (32%), Positives = 190/403 (47%), Gaps = 32/403 (7%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
Query: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 687 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 737
Query: 842 TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMR 901
W SDW CS CG G R V C S + P C ++P +
Sbjct: 738 DRQWTVSDW-GPCSGSCGQGRTIRHVYCKTSDGRVVP---------ESQCQMETKPLAIH 787
Query: 902 ACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
C C W W C++ CG G ++R ++C+ + S C +PP
Sbjct: 788 PCGDKNCPA--HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPE 845
Query: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCN 1021
C + C +W+++PWS C+++C G + R+V+C + C P ++P ++ C+
Sbjct: 846 ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACD 903
Query: 1022 SQPC-SQRPDDQCKDS-SPHCPLVVQARLCVYPYYTATCCRSC 1062
QPC ++ PDD C+D +C L ++ LC + YY+ CCRSC
Sbjct: 904 LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
Score = 152 bits (384), Expect = 2e-36
Identities = 86/247 (34%), Positives = 131/247 (53%), Gaps = 9/247 (3%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQ----GSQRCE 419
C+G S++ + C CPP+ R QC +FNS + G+ +QW+P S+ C+
Sbjct: 90 CTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCD 149
Query: 420 LNCRPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
L+C + + +DGT C+ +CV+G+C GCDG+L S D CG+C
Sbjct: 150 LHCTTVDGQRQLM--VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQ 207
Query: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIING 538
GD S+C V+GN LGY + IPAGA +QI + + S++ LAL G NG
Sbjct: 208 GDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNG 267
Query: 539 NWAVDPPGSYRAGGTVFRYNRPPREEGKG-ESLSAEGPTTQPVDVYMIFQE-ENPGVFYQ 596
N+ VD P ++ GTV +Y RP G E + A+GPT Q ++V + Q ++P + ++
Sbjct: 268 NYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFE 327
Query: 597 YVISSPP 603
Y + PP
Sbjct: 328 YTLLQPP 334
Score = 66.2 bits (160), Expect = 2e-10
Identities = 42/137 (30%), Positives = 59/137 (43%), Gaps = 13/137 (9%)
Query: 898 PDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLP 957
P R + P + +RW CS+ C +G +CV G E S C L
Sbjct: 553 PKARKQGVSPADM-YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALT 608
Query: 958 RP-PALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLS------TNQTLSTRC-- 1008
RP P + C G+ CQ RW ++ WS CSR+C G Q R V+C + S C
Sbjct: 609 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
Query: 1009 PPQLRPSRKRPCNSQPC 1025
+RP ++ C + C
Sbjct: 669 AEAVRPEERKTCRNPAC 685
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 774 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 832
Query: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 833 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
Query: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
+ + P + C P N + ++ LCGHW
Sbjct: 892 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
Score = 40.8 bits (94), Expect = 0.007
Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 8/73 (10%)
Query: 4 WTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQ--GPEGV---WGPWVQWASCSQ 58
W W + LL+L++ V +G + +PT G + WG W +W +CS+
Sbjct: 5 WQCSCWAWFLLVLAV---VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSR 61
Query: 59 PCGVGVQRRSRTC 71
CG GV + R C
Sbjct: 62 SCGGGVTSQERHC 74
Score = 38.9 bits (89), Expect = 0.026
Identities = 35/119 (29%), Positives = 44/119 (36%), Gaps = 35/119 (29%)
Query: 977 TPWSPCSRSCQGGTQTREVQCLST---------NQTLS-----------TRCPPQLRPSR 1016
T W+ CSRSC GG ++E CL N+T + CPP R R
Sbjct: 54 TKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFR 113
Query: 1017 KRPC---NSQPCSQR--------PDDQCKDSSP----HCPLVVQARLCVYPYYTATCCR 1060
+ C NS + R PDD SS HC V R + P T C+
Sbjct: 114 EEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCK 172
Score = 36.2 bits (82), Expect = 0.17
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 701 DERSCAAGARPPASPEPCHGTPCPPYW--EAGEWTSCSRSCGPGTQHRQLQCRQE 753
D S + P S GT +W E +WT+CSRSCG G ++ C Q+
Sbjct: 23 DTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
Score = 35.0 bits (79), Expect = 0.38
Identities = 48/197 (24%), Positives = 70/197 (35%), Gaps = 33/197 (16%)
Query: 815 GDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWS--SKCSAECGTGIQRRSVVCLGS 872
GD VS P+ + + G TA++ +W+ + CS CG G+ + CL
Sbjct: 22 GDTVS----TGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
Query: 873 GAALGPGQG-EAGAGTG---QSCPTGSRPPDMRACSLGPC---------ERTWRW---YT 916
PG G GT Q C PPD R+ C RT +W Y
Sbjct: 78 RRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYP 137
Query: 917 GPWGECSSE-----CGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQ 971
+ SS+ C + +R ++ ++ GT +T L C+ C
Sbjct: 138 DDYVHISSKPCDLHCTTVDGQRQLMVPARDGTSCKLTD------LRGVCVSGKCEPIGCD 191
Query: 972 DRWFSTPWSPCSRSCQG 988
FST CQG
Sbjct: 192 GVLFSTHTLDKCGICQG 208
>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
Length = 660
Score = 225 bits (573), Expect = 2e-58
Identities = 130/403 (32%), Positives = 190/403 (47%), Gaps = 32/403 (7%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 277 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 335
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 336 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 395
Query: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 396 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 446
Query: 842 TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMR 901
W SDW CS CG G R V C S + P C ++P +
Sbjct: 447 DRQWTVSDW-GPCSGSCGQGRTIRHVYCKTSDGRVVP---------ESQCQMETKPLAIH 496
Query: 902 ACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
C C W W C++ CG G ++R ++C+ + S C +PP
Sbjct: 497 PCGDKNCPA--HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPE 554
Query: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCN 1021
C + C +W+++PWS C+++C G + R+V+C + C P ++P ++ C+
Sbjct: 555 ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACD 612
Query: 1022 SQPC-SQRPDDQCKDS-SPHCPLVVQARLCVYPYYTATCCRSC 1062
QPC ++ PDD C+D +C L ++ LC + YY+ CCRSC
Sbjct: 613 LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 655
Score = 66.2 bits (160), Expect = 2e-10
Identities = 42/137 (30%), Positives = 59/137 (43%), Gaps = 13/137 (9%)
Query: 898 PDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLP 957
P R + P + +RW CS+ C +G +CV G E S C L
Sbjct: 262 PKARKQGVSPADM-YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALT 317
Query: 958 RP-PALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLS------TNQTLSTRC-- 1008
RP P + C G+ CQ RW ++ WS CSR+C G Q R V+C + S C
Sbjct: 318 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
Query: 1009 PPQLRPSRKRPCNSQPC 1025
+RP ++ C + C
Sbjct: 378 AEAVRPEERKTCRNPAC 394
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 483 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 541
Query: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 542 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 600
Query: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
+ + P + C P N + ++ LCGHW
Sbjct: 601 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 645
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 224 bits (571), Expect = 3e-58
Identities = 161/552 (29%), Positives = 219/552 (39%), Gaps = 112/552 (20%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFN--SQEFMGQLYQWEPFTEVQGSQRCELN 421
C G S + C PCP P R QC A + S + G L V + CEL
Sbjct: 582 CPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT-----AVVVDDKPCELY 636
Query: 422 CRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
C P G + ++V DGT C P D+CV G+C GCDGI+GS + D CGVC GD
Sbjct: 637 CSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDG 696
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
TC LV G+ + G AL+ G+ IN +W
Sbjct: 697 KTCHLVKGDFSHARGT----------------------------ALKD-SGKGSINSDWK 727
Query: 542 VDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVY-MIFQEENPGVFYQYVIS 600
++ PG ++ GT RY R G E +SA+GPT P+ + ++F +++ G+ Y+Y +
Sbjct: 728 IELPGEFQIAGTTVRYVR----RGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVP 783
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
PE P L
Sbjct: 784 VNRTAENQSEPEKPQDSL------------------------------------------ 801
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLC--ISRESGEELDERSCAAGARPPASPEPC 718
W G CS CG G R I C I ++ +++ C +RP C
Sbjct: 802 -----FIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC 856
Query: 719 HGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGS-SVPPERCGHLPRPNITQS 777
+ PC W AG W+ CS +C G QHR++ C + G + P C PRP QS
Sbjct: 857 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQS 915
Query: 778 CQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREAC 836
C+ + C WE S WSQCS CG+G R V C + G +P + EAC
Sbjct: 916 CEGQDCLSIWE-ASEWSQCSASCGKGVWKRTVACTNSQGK-------CDASTRPRAEEAC 967
Query: 837 DMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSR 896
+ W DWS+ CS+ CG G+Q R V C+ + G CP S+
Sbjct: 968 EDYSGCYEWKTGDWST-CSSTCGKGLQSRVVQCM----------HKVTGRHGSECPALSK 1016
Query: 897 PPDMRACSLGPC 908
P R C C
Sbjct: 1017 PAPYRQCYQEVC 1028
Score = 126 bits (317), Expect = 1e-28
Identities = 82/308 (26%), Positives = 122/308 (39%), Gaps = 47/308 (15%)
Query: 790 SPWSQCSVRCGRGQRSRQVRC---VGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWF 846
S W CSV+CG G+R V C V V++ +C P C++ PC + W
Sbjct: 807 SGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWV 866
Query: 847 HSDWSSKCSAECGTGIQRRSVVCL-----GSGAALGPGQGEAGAGTGQSCPTGSRPPDMR 901
WS CSA C G Q R V C+ G+ A P CP G RP ++
Sbjct: 867 AGPWSP-CSATCEKGFQHREVTCVYQLQNGTHVATRP----------LYCP-GPRPAAVQ 914
Query: 902 ACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
+C C W W +CS+ CG G +R + C + G C RP A
Sbjct: 915 SCEGQDCLSIWE--ASEWSQCSASCGKGVWKRTVACTNSQG---------KCDASTRPRA 963
Query: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCL-STNQTLSTRCPPQLRPSRKRPC 1020
+ C+ + W + WS CS +C G Q+R VQC+ + CP +P+ R C
Sbjct: 964 EEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQC 1023
Query: 1021 NSQPCSQRPDDQCKDS---------------SPHCPLVVQARLCVYPYYTATCCRSCAHV 1065
+ C+ R + S + +C ++ + LC + CC++C
Sbjct: 1024 YQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDF 1083
Query: 1066 LERSPQDP 1073
+ P
Sbjct: 1084 YANKMRQP 1091
Score = 113 bits (282), Expect = 1e-24
Identities = 70/207 (33%), Positives = 94/207 (45%), Gaps = 17/207 (8%)
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRP-PDMRAC 903
W HS W CS +CG G +R V C ++ CP SRP P +R C
Sbjct: 804 WTHSGWEG-CSVQCGGGERRTIVSCTRIVNKTTTLVNDS------DCPQASRPEPQVRRC 856
Query: 904 SLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNV-TSPSNCSHLPRPPAL 962
+L PC+ RW GPW CS+ C G Q R++ CV +L +V T P C PRP A+
Sbjct: 857 NLHPCQS--RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAV 913
Query: 963 QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNS 1022
Q C+GQ C W ++ WS CS SC G R V C ++ +C RP + C
Sbjct: 914 QSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNS----QGKCDASTRPRAEEACED 969
Query: 1023 -QPCSQRPDDQCKDSSPHCPLVVQARL 1048
C + S C +Q+R+
Sbjct: 970 YSGCYEWKTGDWSTCSSTCGKGLQSRV 996
Score = 81.6 bits (200), Expect = 4e-15
Identities = 43/126 (34%), Positives = 61/126 (48%), Gaps = 8/126 (6%)
Query: 907 PCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRP-PALQPC 965
P + + W W CS +CG G +R + C + + + S+C RP P ++ C
Sbjct: 797 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC 856
Query: 966 QGQACQDRWFSTPWSPCSRSCQGGTQTREVQC---LSTNQTLSTR---CPPQLRPSRKRP 1019
CQ RW + PWSPCS +C+ G Q REV C L ++TR CP RP+ +
Sbjct: 857 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGP-RPAAVQS 915
Query: 1020 CNSQPC 1025
C Q C
Sbjct: 916 CEGQDC 921
Score = 52.4 bits (124), Expect = 2e-06
Identities = 94/398 (23%), Positives = 138/398 (34%), Gaps = 67/398 (16%)
Query: 702 ERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGG----- 756
++ C AG +P P H W G W+ CSR+CG G + RQ +C G
Sbjct: 524 DKWCRAGECVSKTPIPEHVDGDWSPW--GAWSMCSRTCGTGARFRQRKCDNPPPGPGGTH 581
Query: 757 -GGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQ------------CSVRCG-RG 802
G+SV C +LP P S + + C + SP + C + C G
Sbjct: 582 CPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLG 641
Query: 803 QRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGI 862
+ S + V+++ P P + C G C C G+
Sbjct: 642 KESPLL---------VADRVLDGTPCGPYETDLCVHGKCQ--------KIGCDGIIGSAA 684
Query: 863 QR-RSVVCLGSGAALGPGQGEAGAGTG---QSCPTGSRPPDMRACSLGPCE---RTWRWY 915
+ R VC G G +G+ G + GS D + G + T R+
Sbjct: 685 KEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQIAGTTVRYV 744
Query: 916 -TGPWGECSSECGSGTQRRDIICV---SKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQ 971
G W + S++ + ++ + G + T P N + +P + Q
Sbjct: 745 RRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRT---AENQSEPEKPQDSL 801
Query: 972 DRWFSTPWSPCSRSCQGGTQTREVQCL-----STNQTLSTRCPPQLRPS-RKRPCNSQPC 1025
W + W CS C GG + V C +T + CP RP + R CN PC
Sbjct: 802 FIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC 861
Query: 1026 SQR----PDDQCKDSSPHCPLVVQAR--LCVYPYYTAT 1057
R P C S C Q R CVY T
Sbjct: 862 QSRWVAGPWSPC---SATCEKGFQHREVTCVYQLQNGT 896
Score = 41.2 bits (95), Expect = 0.005
Identities = 14/31 (45%), Positives = 18/31 (58%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
+G W PW W+ CS+ CG G + R R C P
Sbjct: 543 DGDWSPWGAWSMCSRTCGTGARFRQRKCDNP 573
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 220 bits (561), Expect = 5e-57
Identities = 208/724 (28%), Positives = 270/724 (37%), Gaps = 78/724 (10%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQ-----LYQW-EPFTEVQGSQR 417
C G Q C+ C Q + + QCA + Q Y W QG
Sbjct: 392 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 451
Query: 418 CELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRP 471
C CR G F ++ + DGT C P P +CV+G C + GCDG + S +
Sbjct: 452 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 511
Query: 472 DGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG 531
D C VCGGD+STC G+ T G Y L + + IA RP +LA+R G
Sbjct: 512 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IG 569
Query: 532 GRSIINGNWAVDPPGSYRA----GGTVFRYNRPPREEGKGESLSAEGPTTQPVD--VYMI 585
GR ++ G ++ P +Y + G +R + E + GP + D VY
Sbjct: 570 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 629
Query: 586 FQEE-----NPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPG 640
+ EE P + + Y P P LR
Sbjct: 630 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 689
Query: 641 TLQRQVRIPQMPAPPHPRTPLGSPAA-YWKRVGHSACSASCGKGVWRPIFLCISRESG-- 697
T+Q Q Q P P P + P YW CSASCG G+ C+ +
Sbjct: 690 TVQCQGS--QQP-PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLL 746
Query: 698 EELDERSCAAGARPPA-SPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGG 756
+ L C AGA+ PA + E C+ PCP WE E +SC+ + G G C G
Sbjct: 747 KTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVP--GA 804
Query: 757 GGSSVP-PERCGHL------PRPNITQSCQLRLCGHWEVGS-------PWSQ-------- 794
G P E G + P P + SC GH + S PW
Sbjct: 805 DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGW-GHLDATSAGEKAPSPWGSIRTGAQAA 863
Query: 795 ---------CSVRCGRGQRSRQVRCVGNN-GDEVSEQECASGPPQPPSREACDMGPCTTA 844
CSV CGRG + C+ + V E+ C RE C PC
Sbjct: 864 HVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 923
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
W + + CS CG G+ RR + C A G GE Q C RP ACS
Sbjct: 924 WQYK--LAACSVSCGRGVVRRILYC---ARAHGEDDGEEILLDTQ-CQGLPRPEPQEACS 977
Query: 905 LGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQP 964
L PC RW G CS+ CG GT RR + CV + + C+ L RP A P
Sbjct: 978 LEPCPP--RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVP 1035
Query: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL---STRCPPQLRPSRKRPCN 1021
C C RW W CS SC G Q R CL + C +P R C
Sbjct: 1036 CLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCW 1095
Query: 1022 SQPC 1025
+ PC
Sbjct: 1096 AGPC 1099
Score = 106 bits (264), Expect = 1e-22
Identities = 69/220 (31%), Positives = 92/220 (41%), Gaps = 20/220 (9%)
Query: 674 SACSASCGKGVWRPIFLCI---SRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAG 730
+ACS SCG+GV R I C + GEE+ + G P E C PCPP W+
Sbjct: 929 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 988
Query: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH-WEVG 789
CS SCG GT R + C Q G V C L RP + C + C + W VG
Sbjct: 989 SLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1048
Query: 790 SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSD 849
+ W +CSV CG G + R+ C+G + P+P + C GPC
Sbjct: 1049 T-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVG------ 1101
Query: 850 WSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
CG R+ + G+ GPGQ + G+
Sbjct: 1102 -----QGACG----RQHLEPTGTIDMRGPGQADCAVAIGR 1132
Score = 61.6 bits (148), Expect = 4e-09
Identities = 42/140 (30%), Positives = 60/140 (42%), Gaps = 12/140 (8%)
Query: 898 PDMRACSLGPCER-TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHL 956
PD+ P R W W G CS CG+G + + C+ + E + C
Sbjct: 640 PDITFTYFQPKPRQAWVW-AAVRGPCSVSCGAGLRWVNYSCLDQARKE--LVETVQCQGS 696
Query: 957 PRPPAL-QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPP-QLRP 1014
+PPA + C + C W + PCS SC GG + R V+C+ +L PP + R
Sbjct: 697 QQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRA 756
Query: 1015 SRKRP------CNSQPCSQR 1028
++P CN QPC R
Sbjct: 757 GAQQPAVALETCNPQPCPAR 776
Score = 40.8 bits (94), Expect = 0.007
Identities = 52/202 (25%), Positives = 67/202 (33%), Gaps = 52/202 (25%)
Query: 730 GEWTS------CSRSCGPGTQHRQLQC---RQEFGGG---GSSVPPERCGHLPRPNITQS 777
G W+S CSRSCG G R+ QC R FGG G+ + E C TQ+
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN-------TQA 406
Query: 778 C---QLRLCG---------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGN 813
C QL HW P SQ C R+ +
Sbjct: 407 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 466
Query: 814 NGDE-VSEQEC-ASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
GD + C SGP + + C G C T S+ + R VC G
Sbjct: 467 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQ-------QVWDRCQVCGG 519
Query: 872 SGAALGPGQGEAGAGTGQSCPT 893
+ P +G AG + T
Sbjct: 520 DNSTCSPRKGSFTAGRAREYVT 541
Score = 37.4 bits (85), Expect = 0.077
Identities = 23/60 (38%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 969 ACQDRWFST-PWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
A RW S P SPCSRSC GG TR QC + R + CN+Q C +
Sbjct: 351 AVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG-ADLQAEMCNTQACEK 409
Score = 33.1 bits (74), Expect = 1.4
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRH-PEALLPRG 99
W CS CG G+QRR TC P Q P+P +H P+ + RG
Sbjct: 1050 WMECSVSCGDGIQRRRDTCLGPQAQ----APVPADFCQHLPKPVTVRG 1093
Score = 31.6 bits (70), Expect = 4.2
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G W W + CS+ CG GV R R C P
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 383
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 220 bits (561), Expect = 5e-57
Identities = 208/724 (28%), Positives = 270/724 (37%), Gaps = 78/724 (10%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQ-----LYQW-EPFTEVQGSQR 417
C G Q C+ C Q + + QCA + Q Y W QG
Sbjct: 423 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 482
Query: 418 CELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRP 471
C CR G F ++ + DGT C P P +CV+G C + GCDG + S +
Sbjct: 483 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 542
Query: 472 DGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG 531
D C VCGGD+STC G+ T G Y L + + IA RP +LA+R G
Sbjct: 543 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IG 600
Query: 532 GRSIINGNWAVDPPGSYRA----GGTVFRYNRPPREEGKGESLSAEGPTTQPVD--VYMI 585
GR ++ G ++ P +Y + G +R + E + GP + D VY
Sbjct: 601 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 660
Query: 586 FQEE-----NPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPG 640
+ EE P + + Y P P LR
Sbjct: 661 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 720
Query: 641 TLQRQVRIPQMPAPPHPRTPLGSPAA-YWKRVGHSACSASCGKGVWRPIFLCISRESG-- 697
T+Q Q Q P P P + P YW CSASCG G+ C+ +
Sbjct: 721 TVQCQGS--QQP-PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLL 777
Query: 698 EELDERSCAAGARPPA-SPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGG 756
+ L C AGA+ PA + E C+ PCP WE E +SC+ + G G C G
Sbjct: 778 KTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVP--GA 835
Query: 757 GGSSVP-PERCGHL------PRPNITQSCQLRLCGHWEVGS-------PWSQ-------- 794
G P E G + P P + SC GH + S PW
Sbjct: 836 DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGW-GHLDATSAGEKAPSPWGSIRTGAQAA 894
Query: 795 ---------CSVRCGRGQRSRQVRCVGNN-GDEVSEQECASGPPQPPSREACDMGPCTTA 844
CSV CGRG + C+ + V E+ C RE C PC
Sbjct: 895 HVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 954
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
W + + CS CG G+ RR + C A G GE Q C RP ACS
Sbjct: 955 WQYK--LAACSVSCGRGVVRRILYC---ARAHGEDDGEEILLDTQ-CQGLPRPEPQEACS 1008
Query: 905 LGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQP 964
L PC RW G CS+ CG GT RR + CV + + C+ L RP A P
Sbjct: 1009 LEPCPP--RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVP 1066
Query: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL---STRCPPQLRPSRKRPCN 1021
C C RW W CS SC G Q R CL + C +P R C
Sbjct: 1067 CLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCW 1126
Query: 1022 SQPC 1025
+ PC
Sbjct: 1127 AGPC 1130
Score = 106 bits (264), Expect = 1e-22
Identities = 69/220 (31%), Positives = 92/220 (41%), Gaps = 20/220 (9%)
Query: 674 SACSASCGKGVWRPIFLCI---SRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAG 730
+ACS SCG+GV R I C + GEE+ + G P E C PCPP W+
Sbjct: 960 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 1019
Query: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH-WEVG 789
CS SCG GT R + C Q G V C L RP + C + C + W VG
Sbjct: 1020 SLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1079
Query: 790 SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSD 849
+ W +CSV CG G + R+ C+G + P+P + C GPC
Sbjct: 1080 T-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVG------ 1132
Query: 850 WSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
CG R+ + G+ GPGQ + G+
Sbjct: 1133 -----QGACG----RQHLEPTGTIDMRGPGQADCAVAIGR 1163
Score = 61.6 bits (148), Expect = 4e-09
Identities = 42/140 (30%), Positives = 60/140 (42%), Gaps = 12/140 (8%)
Query: 898 PDMRACSLGPCER-TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHL 956
PD+ P R W W G CS CG+G + + C+ + E + C
Sbjct: 671 PDITFTYFQPKPRQAWVW-AAVRGPCSVSCGAGLRWVNYSCLDQARKE--LVETVQCQGS 727
Query: 957 PRPPAL-QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPP-QLRP 1014
+PPA + C + C W + PCS SC GG + R V+C+ +L PP + R
Sbjct: 728 QQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRA 787
Query: 1015 SRKRP------CNSQPCSQR 1028
++P CN QPC R
Sbjct: 788 GAQQPAVALETCNPQPCPAR 807
Score = 40.8 bits (94), Expect = 0.007
Identities = 52/202 (25%), Positives = 67/202 (33%), Gaps = 52/202 (25%)
Query: 730 GEWTS------CSRSCGPGTQHRQLQC---RQEFGGG---GSSVPPERCGHLPRPNITQS 777
G W+S CSRSCG G R+ QC R FGG G+ + E C TQ+
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN-------TQA 437
Query: 778 C---QLRLCG---------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGN 813
C QL HW P SQ C R+ +
Sbjct: 438 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 497
Query: 814 NGDE-VSEQEC-ASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
GD + C SGP + + C G C T S+ + R VC G
Sbjct: 498 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQ-------QVWDRCQVCGG 550
Query: 872 SGAALGPGQGEAGAGTGQSCPT 893
+ P +G AG + T
Sbjct: 551 DNSTCSPRKGSFTAGRAREYVT 572
Score = 37.4 bits (85), Expect = 0.077
Identities = 23/60 (38%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 969 ACQDRWFST-PWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
A RW S P SPCSRSC GG TR QC + R + CN+Q C +
Sbjct: 382 AVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG-ADLQAEMCNTQACEK 440
Score = 33.1 bits (74), Expect = 1.4
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRH-PEALLPRG 99
W CS CG G+QRR TC P Q P+P +H P+ + RG
Sbjct: 1081 WMECSVSCGDGIQRRRDTCLGPQAQ----APVPADFCQHLPKPVTVRG 1124
Score = 31.6 bits (70), Expect = 4.2
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G W W + CS+ CG GV R R C P
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 414
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 220 bits (561), Expect = 5e-57
Identities = 208/724 (28%), Positives = 270/724 (37%), Gaps = 78/724 (10%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQ-----LYQW-EPFTEVQGSQR 417
C G Q C+ C Q + + QCA + Q Y W QG
Sbjct: 423 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 482
Query: 418 CELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRP 471
C CR G F ++ + DGT C P P +CV+G C + GCDG + S +
Sbjct: 483 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 542
Query: 472 DGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG 531
D C VCGGD+STC G+ T G Y L + + IA RP +LA+R G
Sbjct: 543 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IG 600
Query: 532 GRSIINGNWAVDPPGSYRA----GGTVFRYNRPPREEGKGESLSAEGPTTQPVD--VYMI 585
GR ++ G ++ P +Y + G +R + E + GP + D VY
Sbjct: 601 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 660
Query: 586 FQEE-----NPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPG 640
+ EE P + + Y P P LR
Sbjct: 661 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 720
Query: 641 TLQRQVRIPQMPAPPHPRTPLGSPAA-YWKRVGHSACSASCGKGVWRPIFLCISRESG-- 697
T+Q Q Q P P P + P YW CSASCG G+ C+ +
Sbjct: 721 TVQCQGS--QQP-PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLL 777
Query: 698 EELDERSCAAGARPPA-SPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGG 756
+ L C AGA+ PA + E C+ PCP WE E +SC+ + G G C G
Sbjct: 778 KTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVP--GA 835
Query: 757 GGSSVP-PERCGHL------PRPNITQSCQLRLCGHWEVGS-------PWSQ-------- 794
G P E G + P P + SC GH + S PW
Sbjct: 836 DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGW-GHLDATSAGEKAPSPWGSIRTGAQAA 894
Query: 795 ---------CSVRCGRGQRSRQVRCVGNN-GDEVSEQECASGPPQPPSREACDMGPCTTA 844
CSV CGRG + C+ + V E+ C RE C PC
Sbjct: 895 HVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 954
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
W + + CS CG G+ RR + C A G GE Q C RP ACS
Sbjct: 955 WQYK--LAACSVSCGRGVVRRILYC---ARAHGEDDGEEILLDTQ-CQGLPRPEPQEACS 1008
Query: 905 LGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQP 964
L PC RW G CS+ CG GT RR + CV + + C+ L RP A P
Sbjct: 1009 LEPCPP--RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVP 1066
Query: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL---STRCPPQLRPSRKRPCN 1021
C C RW W CS SC G Q R CL + C +P R C
Sbjct: 1067 CLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCW 1126
Query: 1022 SQPC 1025
+ PC
Sbjct: 1127 AGPC 1130
Score = 61.6 bits (148), Expect = 4e-09
Identities = 42/140 (30%), Positives = 60/140 (42%), Gaps = 12/140 (8%)
Query: 898 PDMRACSLGPCER-TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHL 956
PD+ P R W W G CS CG+G + + C+ + E + C
Sbjct: 671 PDITFTYFQPKPRQAWVW-AAVRGPCSVSCGAGLRWVNYSCLDQARKE--LVETVQCQGS 727
Query: 957 PRPPAL-QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPP-QLRP 1014
+PPA + C + C W + PCS SC GG + R V+C+ +L PP + R
Sbjct: 728 QQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRA 787
Query: 1015 SRKRP------CNSQPCSQR 1028
++P CN QPC R
Sbjct: 788 GAQQPAVALETCNPQPCPAR 807
Score = 40.8 bits (94), Expect = 0.007
Identities = 52/202 (25%), Positives = 67/202 (33%), Gaps = 52/202 (25%)
Query: 730 GEWTS------CSRSCGPGTQHRQLQC---RQEFGGG---GSSVPPERCGHLPRPNITQS 777
G W+S CSRSCG G R+ QC R FGG G+ + E C TQ+
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN-------TQA 437
Query: 778 C---QLRLCG---------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGN 813
C QL HW P SQ C R+ +
Sbjct: 438 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 497
Query: 814 NGDE-VSEQEC-ASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
GD + C SGP + + C G C T S+ + R VC G
Sbjct: 498 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQ-------QVWDRCQVCGG 550
Query: 872 SGAALGPGQGEAGAGTGQSCPT 893
+ P +G AG + T
Sbjct: 551 DNSTCSPRKGSFTAGRAREYVT 572
Score = 37.4 bits (85), Expect = 0.077
Identities = 23/60 (38%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 969 ACQDRWFST-PWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
A RW S P SPCSRSC GG TR QC + R + CN+Q C +
Sbjct: 382 AVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG-ADLQAEMCNTQACEK 440
Score = 35.8 bits (81), Expect = 0.22
Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 8/73 (10%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRH-PEALLPRGQGPRP---QTSP 108
W CS CG G+QRR TC P Q P+P +H P+ + RG P Q +P
Sbjct: 1081 WMECSVSCGDGIQRRRDTCLGPQAQ----APVPADFCQHLPKPVTVRGCWAGPCVGQGTP 1136
Query: 109 ETLPLYRTQSRGR 121
+P + GR
Sbjct: 1137 SLVPHEEAAAPGR 1149
Score = 31.6 bits (70), Expect = 4.2
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G W W + CS+ CG GV R R C P
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 414
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 209 bits (533), Expect = 9e-54
Identities = 129/341 (37%), Positives = 169/341 (49%), Gaps = 31/341 (9%)
Query: 333 QHPGAWLPLLS---------NGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQ 383
Q PG W P +S G S L P C G+S + R C CPP
Sbjct: 33 QGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEE--PCWGDSHEYRLCQLPDCPPGA 90
Query: 384 PDPRALQCAAFNSQEFMG--QLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGT 441
R LQCA +N + +G + YQW PF +C+LNC G FY +V DGT
Sbjct: 91 VPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPN--QCDLNCLAEGHAFY-HSFGRVLDGT 147
Query: 442 LCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQ 501
C PGA +CVAGRCLS GCDG+LGSG D CG CGG + +C V D G GY
Sbjct: 148 ACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYW 207
Query: 502 KILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPP 561
+ IP GA +++ S N+LAL G GR ++NG+W V PPG+Y A GT Y
Sbjct: 208 NVTLIPEGARHIRVE--HRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYT--- 262
Query: 562 REEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISS---PPPILENPTPEPPVPQL 618
R+ G E+L A GPT+ + + ++ QE NPG+ +++ + P P+ Q
Sbjct: 263 RDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRERYSPFQARVQALGWPLRQP 322
Query: 619 QPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659
QP + +PP APA PA+TP + P PP P T
Sbjct: 323 QPRGVEPQPPAAPAVTPAQTP-------TLAPDPCPPCPDT 356
Score = 44.7 bits (104), Expect = 5e-04
Identities = 19/31 (61%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
QGP G W PWV W CS CG GV RSR C
Sbjct: 33 QGP-GEWTPWVSWTRCSSSCGRGVSVRSRRC 62
Score = 34.3 bits (77), Expect = 0.65
Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 14/62 (22%)
Query: 770 PRPNITQSCQLRLC--------------GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815
PRP++ Q+ L L G W W++CS CGRG R RC+ G
Sbjct: 8 PRPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPG 67
Query: 816 DE 817
+E
Sbjct: 68 EE 69
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 190 bits (483), Expect = 5e-48
Identities = 142/439 (32%), Positives = 196/439 (44%), Gaps = 62/439 (14%)
Query: 364 CSGESEQLRACSQAPCPPEQPDP--RALQCAAFN----SQEFMGQLYQWEP-FTEVQGSQ 416
C G + R+C+ PCP R QC AFN S + W P ++ V
Sbjct: 555 CEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRD 614
Query: 417 RCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGV 476
+C+L CR G ++ KV DGTLC P + +CV G+C+ GCDG LGS +R D CGV
Sbjct: 615 KCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGV 674
Query: 477 CGGDDSTCRLVSGNLTDRGGPL-GYQKILWIPAGALRLQIAQ-----LRPSSNYLALRGP 530
CGGD+ +C+ V+G T P+ GY ++ IPAGA + I Q L NYLAL+
Sbjct: 675 CGGDNKSCKKVTGLFTK---PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNS 731
Query: 531 GGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREEGKG---ESLSAEGPTTQP--VDVYM 584
G+ ++NG++ V G++ RY+ G G ESL A P +P V+V
Sbjct: 732 QGKYLLNGHFVVSAVERDLVVKGSLLRYS------GTGTAVESLQASRPILEPLTVEVLS 785
Query: 585 IFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQR 644
+ + P V Y + + P ++ P+ P R P L
Sbjct: 786 VGKMTPPRVRYSFYLPKEPREDKSSHPKDP----------------------RGPSVLHN 823
Query: 645 QVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERS 704
V + P P A W CSASCG G+ + C R S + +
Sbjct: 824 SV----LSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDC--RGSAGQRTVPA 877
Query: 705 CAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPE 764
C A R P + C G PCP WE W+ CS+SCG G Q R L+C G GG + +
Sbjct: 878 CDAAHR-PVETQAC-GEPCPT-WELSAWSPCSKSCGRGFQRRSLKC---VGHGGRLLARD 931
Query: 765 RCGHLPRPNITQSCQLRLC 783
+C +P C LR C
Sbjct: 932 QCNLHRKPQELDFCVLRPC 950
Score = 75.5 bits (184), Expect = 3e-13
Identities = 43/115 (37%), Positives = 55/115 (47%), Gaps = 8/115 (6%)
Query: 913 RWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQD 972
RW G WG CS+ CGSG Q+R + C G T P+ C RP Q C G+ C
Sbjct: 842 RWVAGSWGPCSASCGSGLQKRAVDCRGSAGQR---TVPA-CDAAHRPVETQAC-GEPC-P 895
Query: 973 RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTR--CPPQLRPSRKRPCNSQPC 1025
W + WSPCS+SC G Q R ++C+ L R C +P C +PC
Sbjct: 896 TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 65.5 bits (158), Expect = 3e-10
Identities = 43/123 (34%), Positives = 52/123 (42%), Gaps = 15/123 (12%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845
W GS W CS CG G + R V C G+ G +P +AC PC T W
Sbjct: 843 WVAGS-WGPCSASCGSGLQKRAVDCRGSAGQRTVP--ACDAAHRPVETQACGE-PCPT-W 897
Query: 846 FHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSL 905
S WS CS CG G QRRS+ C+G G L C +P ++ C L
Sbjct: 898 ELSAWSP-CSKSCGRGFQRRSLKCVGHGGRL---------LARDQCNLHRKPQELDFCVL 947
Query: 906 GPC 908
PC
Sbjct: 948 RPC 950
Score = 37.7 bits (86), Expect = 0.059
Identities = 19/56 (33%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 20 QLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPT 75
+LCL + H+L +G W W + CS+ CG GVQ R C PT
Sbjct: 497 KLCLKGACVERHNLNKHRVDGS-----WAKWDPYGPCSRTCGGGVQLARRQCTNPT 547
Score = 36.2 bits (82), Expect = 0.17
Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%)
Query: 978 PWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPC 1025
P+ PCSR+C GG Q QC + + +R + R CN +PC
Sbjct: 524 PYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR-VKYRSCNLEPC 570
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 180 bits (456), Expect = 7e-45
Identities = 150/505 (29%), Positives = 201/505 (39%), Gaps = 74/505 (14%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQ-EFMGQLYQWEPFTEVQGSQRCELNC 422
C G + + + C+ C D RA QC NS E+ + W P+ +RC L C
Sbjct: 590 CPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYC 649
Query: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
+ + + V DGT C P ICV G C+ GCD +GS + D CGVCGGD+
Sbjct: 650 QSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDN 709
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG-GRSIINGNW 540
S CR V G T LGY K+ IP GA + I + S + LA++ G I+NG
Sbjct: 710 SHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKG 769
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEEN--PGVFYQYV 598
++ G + YN E ESL +GP PV V +I QE + + Y+Y+
Sbjct: 770 EEAKSRTFIDLGVEWDYN----IEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYI 825
Query: 599 I--SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPH 656
I S P I N +Q E+ E
Sbjct: 826 IHEDSVPTINSNNV-------IQEELDTFE------------------------------ 848
Query: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
W S CS CG G + C + + + C A +P
Sbjct: 849 -----------WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRR 897
Query: 717 PCHGTPCP-PYWEAGEWTSCSRSCG-PGTQHRQLQCRQE-FGGGGSSVPPERCGHLPRPN 773
C+ C P W A EW C+++CG G Q R ++C Q G SV + C RP
Sbjct: 898 MCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPE 956
Query: 774 ITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
+ C C W+ G PWS+CSV CG G RQV C GD + +P S
Sbjct: 957 SRRPCNRVPCPAQWKTG-PWSECSVTCGEGTEVRQVLC--RAGDHCDGE-------KPES 1006
Query: 833 REACDMGPCTTAWFHSDWSSKCSAE 857
AC + PC D S C E
Sbjct: 1007 VRACQLPPCNDEPCLGDKSIFCQME 1031
Score = 102 bits (253), Expect = 3e-21
Identities = 67/224 (29%), Positives = 92/224 (41%), Gaps = 20/224 (8%)
Query: 842 TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRP-PDM 900
T W WS +CS CG G Q C + + C +P P
Sbjct: 846 TFEWALKSWS-QCSKPCGGGFQYTKYGCRR--------KSDNKMVHRSFCEANKKPKPIR 896
Query: 901 RACSLGPCERTWRWYTGPWGECSSECGS-GTQRRDIICVSKLGTEFNVTSPSNCSHLPRP 959
R C++ C W W C+ CGS G Q R + C+ L N + S RP
Sbjct: 897 RMCNIQECTHPL-WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRP 955
Query: 960 PALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRP 1019
+ +PC C +W + PWS CS +C GT+ R+V C + + + P +R + P
Sbjct: 956 ESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEK-PESVRACQLPP 1014
Query: 1020 CNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCA 1063
CN +PC D S C + V AR C P Y CC SC+
Sbjct: 1015 CNDEPC-------LGDKSIFCQMEVLARYCSIPGYNKLCCESCS 1051
Score = 87.0 bits (214), Expect = 8e-17
Identities = 67/231 (29%), Positives = 97/231 (41%), Gaps = 21/231 (9%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE-CASGPPQPPSREACDMGPCT-T 843
W + S WSQCS CG G + + C + +++ + C + P R C++ CT
Sbjct: 849 WALKS-WSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 844 AWFHSDWSSKCSAECG-TGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
W +W C+ CG +G Q R+V C L P G RP R
Sbjct: 908 LWVAEEW-EHCTKTCGSSGYQLRTVRC------LQPLLDGTNRSVHSKYCMGDRPESRRP 960
Query: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
C+ PC W+ TGPW ECS CG GT+ R ++C + G + P + R L
Sbjct: 961 CNRVPCPAQWK--TGPWSECSVTCGEGTEVRQVLC--RAGDHCDGEKPESV----RACQL 1012
Query: 963 QPCQGQAC-QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQL 1012
PC + C D+ +R C + + C S ++ ST PP L
Sbjct: 1013 PPCNDEPCLGDKSIFCQMEVLARYCSIPGYNK-LCCESCSKRSSTLPPPYL 1062
Score = 42.7 bits (99), Expect = 0.002
Identities = 16/34 (47%), Positives = 22/34 (64%)
Query: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Q +G WG W ++ SCS+ CG GV+ R+R C P
Sbjct: 548 QKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNP 581
Score = 35.0 bits (79), Expect = 0.38
Identities = 38/138 (27%), Positives = 51/138 (36%), Gaps = 36/138 (26%)
Query: 649 PQMPAPPHPRTPLGSPAAYWKRVGHSACSA-----SCGKGVW-----RPIFLCISRESGE 698
P++P P + + VG+ C+A C K +W P F + G
Sbjct: 466 PKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPC-KQLWCSHPDNPYFC--KTKKGP 522
Query: 699 ELDERSCAAGARPPASPEPCHGTPCPPYWEA----------GEWT---SCSRSCGPGTQH 745
LD CAAG + C+ C W+ G WT SCSR+CG G +
Sbjct: 523 PLDGTECAAG-------KWCYKGHC--MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRF 573
Query: 746 RQLQCRQEFG-GGGSSVP 762
R QC GG P
Sbjct: 574 RTRQCNNPMPINGGQDCP 591
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 176 bits (446), Expect = 1e-43
Identities = 129/446 (28%), Positives = 193/446 (43%), Gaps = 56/446 (12%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C+GE ++ R C+ PC E P R +QC+ F++ + +LY W P + CEL CR
Sbjct: 581 CTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPI--FNPAHPCELYCR 638
Query: 424 PRGFRFYVRHTEKVQDGTLCQPG--APDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
P +F + + V DGT C G + ++C+ G C GCD + S D CGVC GD
Sbjct: 639 PIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDG 698
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG-GRSIINGNW 540
S+C+ V + G GY I IP GA +++ ++ + N+LA+R + +NG +
Sbjct: 699 SSCQTVRKMFKQKEGS-GYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGF 757
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
+ G+Y+ GTVF+Y+R +G E L A GPT + V + ++FQ NPG+ Y+Y I
Sbjct: 758 IIQWNGNYKLAGTVFQYDR----KGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQ 813
Query: 601 SPPPILENPTPE------------------PPVPQLQPEILRVEPPLAPAP--RPARTPG 640
L+N + + + ++ + A P P
Sbjct: 814 KDG--LDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPN 871
Query: 641 TLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCG-KGVWRPIFLCISRESGEE 699
RQ + + PP W ACSA+CG G + LCI +E
Sbjct: 872 --GRQKKCHEKACPPR-----------WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE 918
Query: 700 --LDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGG 757
L C +P CP W G W+ CS SCG G + R + C +
Sbjct: 919 QALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH--- 975
Query: 758 GSSVPPERCGHLPRPNITQSCQLRLC 783
E C +PN C L+ C
Sbjct: 976 -----DEPCDVTRKPNSRALCGLQQC 996
Score = 140 bits (353), Expect = 6e-33
Identities = 109/400 (27%), Positives = 161/400 (40%), Gaps = 54/400 (13%)
Query: 588 EENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVE--PP-------LAPAPRPART 638
E NP ++ + + +E+ T P P L P++ R PP L P+ RP +
Sbjct: 1171 ESNPVIWTKIRVPGNDAPVES-TEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTS 1229
Query: 639 P-GTLQRQVRIPQMPAPPHPRTPLGS---PAAYWKRVGHSACSASCGKGVWRPIFLCISR 694
GT + + + + PA + PLG P K + + ++
Sbjct: 1230 ETGTPRVEGMVTEKPA--NTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTE 1287
Query: 695 ESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEF 754
E L A HG+ +W G W+ CS +CG G R+++C +
Sbjct: 1288 EDATSLITEGFLLNASNYKQLTNGHGSA---HWIVGNWSECSTTCGLGAYWRRVECSTQM 1344
Query: 755 GGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNN 814
C + RP+ + C LR C W+VG+ WS+CS C G + R+++CV +
Sbjct: 1345 DSD--------CAAIQRPDPAKRCHLRPCAGWKVGN-WSKCSRNCSGGFKIREIQCVDSR 1395
Query: 815 GDEVSEQ---ECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
+ +G P PP +C+ PC AW WS +CS CG G+Q R V C G
Sbjct: 1396 DHRNLRPFHCQFLAGIP-PPLSMSCNPEPCE-AWQVEPWS-QCSRSCGGGVQERGVFCPG 1452
Query: 872 SGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQ 931
C RP +C+ C W TG W CS+ CG G Q
Sbjct: 1453 G-----------------LCDWTKRPTSTMSCNEHLC---CHWATGNWDLCSTSCGGGFQ 1492
Query: 932 RRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQ 971
+R + CV G + C H PRPP + C QAC+
Sbjct: 1493 KRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK 1532
Score = 132 bits (333), Expect = 1e-30
Identities = 91/288 (31%), Positives = 118/288 (40%), Gaps = 42/288 (14%)
Query: 785 HWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTA 844
HW VG+ WS+CS CG G R+V C + +CA+ P++ C + PC
Sbjct: 1316 HWIVGN-WSECSTTCGLGAYWRRVEC-----STQMDSDCAAIQRPDPAKR-CHLRPCA-G 1367
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSG--AALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
W +WS KCS C G + R + C+ S L P + AG PP +
Sbjct: 1368 WKVGNWS-KCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIP--------PPLSMS 1418
Query: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
C+ PCE W PW +CS CG G Q R + C L C RP +
Sbjct: 1419 CNPEPCEA---WQVEPWSQCSRSCGGGVQERGVFCPGGL-----------CDWTKRPTST 1464
Query: 963 QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCL-----STNQTLSTRCPPQLRPSRK 1017
C C W + W CS SC GG Q R VQC+ T C + RP
Sbjct: 1465 MSCNEHLCC-HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEF 1523
Query: 1018 RPCNSQPCSQRPDDQC---KDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
+ CN Q C + D C K S+ C + + C P A CC SC
Sbjct: 1524 KKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
Score = 110 bits (274), Expect = 9e-24
Identities = 65/182 (35%), Positives = 88/182 (48%), Gaps = 12/182 (6%)
Query: 667 YWKRVGH-SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPP 725
Y+ + GH + CS +CG G+ R CI + G + C +P + CH CPP
Sbjct: 826 YFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGM-VKATFCDPETQPNGRQKKCHEKACPP 884
Query: 726 YWEAGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLR-LC 783
W AGEW +CS +CGP G + R + C Q ++PP C HL +P SC LC
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILC 944
Query: 784 -GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCT 842
W VG+ WS+CSV CG G R R V C N+ E +P SR C + C
Sbjct: 945 PSDWTVGN-WSECSVSCGGGVRIRSVTCAKNH------DEPCDVTRKPNSRALCGLQQCP 997
Query: 843 TA 844
++
Sbjct: 998 SS 999
Score = 79.0 bits (193), Expect = 2e-14
Identities = 71/298 (23%), Positives = 111/298 (37%), Gaps = 54/298 (18%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845
W+ G W++CSV CG G R + C+ V C ++ C C W
Sbjct: 828 WQYGH-WTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRW 886
Query: 846 FHSDWSSKCSAECGT-GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
+ +W + CSA CG G ++R+V+C+ + + + A C +P + +C+
Sbjct: 887 WAGEWEA-CSATCGPHGEKKRTVLCIQTMVS------DEQALPPTDCQHLLKPKTLLSCN 939
Query: 905 ---LGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSN--------- 952
L P + W G W ECS CG G + R + C +VT N
Sbjct: 940 RDILCPSD----WTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQ 995
Query: 953 --------------CSHLPRPPALQPCQGQACQDRWFSTPW---------------SPCS 983
S+ PP L+P + R +TP SP +
Sbjct: 996 CPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTT 1055
Query: 984 RSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQCKDSSPHCP 1041
S +G ++ Q ST LS+R + + SQ S +P ++ SS P
Sbjct: 1056 ASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGP 1113
Score = 59.7 bits (143), Expect = 1e-08
Identities = 37/120 (30%), Positives = 54/120 (45%), Gaps = 10/120 (8%)
Query: 909 ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQ-PCQG 967
++ + W G W ECS CG+G +R+ C+ K + + C +P Q C
Sbjct: 823 QQMYFWQYGHWTECSVTCGTGIRRQTAHCIKK---GRGMVKATFCDPETQPNGRQKKCHE 879
Query: 968 QACQDRWFSTPWSPCSRSC-QGGTQTREVQCLST----NQTL-STRCPPQLRPSRKRPCN 1021
+AC RW++ W CS +C G + R V C+ T Q L T C L+P CN
Sbjct: 880 KACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCN 939
Score = 42.4 bits (98), Expect = 0.002
Identities = 17/38 (44%), Positives = 21/38 (55%), Gaps = 3/38 (7%)
Query: 40 GQGPEGV---WGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G+ PE + WG W W+ CS+ CG GVQ R C P
Sbjct: 535 GKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNP 572
Score = 36.2 bits (82), Expect = 0.17
Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 5/54 (9%)
Query: 973 RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTR-CPPQLRPSRKRPCNSQPC 1025
RW +PWS CSR+C G Q+ E C + + C + + R R CN PC
Sbjct: 547 RW--SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERK--RYRLCNVHPC 596
Score = 33.1 bits (74), Expect = 1.4
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 4/58 (6%)
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
G W SPWS CS CG G +S + C NN + + +G + C++ PC
Sbjct: 543 GGWGRWSPWSHCSRTCGAGVQSAERLC--NNPEPKFGGKYCTG--ERKRYRLCNVHPC 596
Score = 30.4 bits (67), Expect = 9.4
Identities = 11/25 (44%), Positives = 14/25 (56%), Gaps = 2/25 (8%)
Query: 913 RWYTGPWGECSSECGSGTQRRDIIC 937
RW PW CS CG+G Q + +C
Sbjct: 547 RW--SPWSHCSRTCGAGVQSAERLC 569
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 169 bits (429), Expect = 1e-41
Identities = 132/486 (27%), Positives = 188/486 (38%), Gaps = 63/486 (12%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF-MGQLYQWEPFTEVQGSQRCELNC 422
C G + + C+ CP D RA QCA NS + W P+ +Q+CEL C
Sbjct: 591 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELIC 650
Query: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
+ V + V DGT C P +C G C+ GCD +GS + D CGVCGGD+
Sbjct: 651 QSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDN 710
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
S CR V G L G K++ IPAGA +QI L S + + ++ + G++
Sbjct: 711 SHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQ-----VTGSFI 765
Query: 542 VDPPGSYRAGGTVFRYNRPPRE--EGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVI 599
++P G T + E ESL GP + + + +
Sbjct: 766 LNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILAL-------------- 811
Query: 600 SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659
PP PR + + + +P + +
Sbjct: 812 ---------------------------PPTEGGPRSSLAYKYVIHEDLLPLIGSN---NV 841
Query: 660 PLGSPAAY-WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
L Y W + CS +CG G+ + C R + C RP C
Sbjct: 842 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 901
Query: 719 HGTPCP-PYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ 776
+ PC P W EW +CSRSCG G Q R +QC G V P + RP +
Sbjct: 902 NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARR 961
Query: 777 SCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREA 835
C C W +G+ WSQCS CG G + RQV C N + + E +P + +
Sbjct: 962 PCLRVPCPAQWRLGA-WSQCSATCGEGIQQRQVVC-RTNANSLGHCE----GDRPDTVQV 1015
Query: 836 CDMGPC 841
C + C
Sbjct: 1016 CSLPAC 1021
Score = 98.2 bits (243), Expect = 4e-20
Identities = 79/280 (28%), Positives = 111/280 (39%), Gaps = 40/280 (14%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQP-PSREACDMGPCTT- 843
W + S W+ CS CG G + + C + ++ +P P R C+ PC+
Sbjct: 851 WALKS-WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909
Query: 844 AWFHSDWSSKCSAECGT-GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
W +W + CS CG G+Q R + CL L G ++C G RP R
Sbjct: 910 VWVTEEWGA-CSRSCGKLGVQTRGIQCL-----LPLSNGTHKVMPAKAC-AGDRPEARRP 962
Query: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
C PC WR G W +CS+ CG G Q+R ++C + N S +C RP +
Sbjct: 963 CLRVPCPAQWR--LGAWSQCSATCGEGIQQRQVVCRT------NANSLGHCEG-DRPDTV 1013
Query: 963 QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNS 1022
Q C AC + Q T +V L T + L P K ++
Sbjct: 1014 QVCSLPAC------------GGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKIS-ST 1060
Query: 1023 QPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
+PC+ D S C + V R C P Y CC SC
Sbjct: 1061 EPCTG-------DRSVFCQMEVLDRYCSIPGYHRLCCVSC 1093
Score = 49.3 bits (116), Expect = 2e-05
Identities = 22/57 (38%), Positives = 31/57 (54%)
Query: 30 GHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP 86
GH + E+ G +G W W ++ SCS+ CG GV+ RSR+C P+ L L P
Sbjct: 538 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGP 594
Score = 36.2 bits (82), Expect = 0.17
Identities = 83/344 (24%), Positives = 116/344 (33%), Gaps = 84/344 (24%)
Query: 50 WV--QWASCSQPCG-VGVQRRSRTCQLPTVQ-LHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
WV +W +CS+ CG +GVQ R C LP H +P PEA P + P P
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 970
Query: 106 TSPETLPLYRTQSRGRG-----GPLRGPASHLG-----REETQEI---RAARRSRLRDPI 152
+ + G G R A+ LG R +T ++ A + +
Sbjct: 971 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1030
Query: 153 KPGMFGYGR-----VPFALPLHRNR----------------------RHPRSPPRSELSL 185
+ ++ G VP + PLH R+ P L
Sbjct: 1031 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1090
Query: 186 ISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTP-SPQAEPLSPETAQTEVAPRT 244
+S + + P+P P P T LPP TP SP P P A P
Sbjct: 1091 VSCIKKASGPNPGPDPGP--------TSLPP----FSTPGSPLPGPQDPADA---AEPPG 1135
Query: 245 RPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRP----- 299
+P H +A T+ P + G +P+ P + SP G P
Sbjct: 1136 KPTGSEDHQHGRA--TQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQ 1193
Query: 300 DPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLS 343
P P VP +GQ G+ D +HPG LP S
Sbjct: 1194 TPTP-VPEDKGQPGE----------------DLRHPGTSLPAAS 1220
Score = 33.9 bits (76), Expect = 0.85
Identities = 52/201 (25%), Positives = 69/201 (34%), Gaps = 38/201 (18%)
Query: 43 PEGVWGPW------VQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALL 96
PEG W P + S ++PC RS CQ+ + + S+P R
Sbjct: 1040 PEGQWVPQSEPLHPINKISSTEPC---TGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKK 1096
Query: 97 PRGQGPRPQTSPETLPLYRTQSRGRGGP------LRGPASHLGREETQEIRAARRSRLRD 150
G P P P +LP + T GP P G E+ Q RA + D
Sbjct: 1097 ASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALD 1156
Query: 151 PIKPGMFGYGRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIP-----SPTPRAEPFS 205
PG + PFA P +P IS +P +PTP E
Sbjct: 1157 TSSPGT----QHPFA---------PETPIPGASWSISPTTPGGLPWGWTQTPTPVPED-- 1201
Query: 206 ANGSPQTEL--PPTELSVHTP 224
G P +L P T L +P
Sbjct: 1202 -KGQPGEDLRHPGTSLPAASP 1221
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 169 bits (429), Expect = 1e-41
Identities = 132/486 (27%), Positives = 188/486 (38%), Gaps = 63/486 (12%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF-MGQLYQWEPFTEVQGSQRCELNC 422
C G + + C+ CP D RA QCA NS + W P+ +Q+CEL C
Sbjct: 594 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELIC 653
Query: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
+ V + V DGT C P +C G C+ GCD +GS + D CGVCGGD+
Sbjct: 654 QSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDN 713
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
S CR V G L G K++ IPAGA +QI L S + + ++ + G++
Sbjct: 714 SHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQ-----VTGSFI 768
Query: 542 VDPPGSYRAGGTVFRYNRPPRE--EGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVI 599
++P G T + E ESL GP + + + +
Sbjct: 769 LNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILAL-------------- 814
Query: 600 SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659
PP PR + + + +P + +
Sbjct: 815 ---------------------------PPTEGGPRSSLAYKYVIHEDLLPLIGSN---NV 844
Query: 660 PLGSPAAY-WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
L Y W + CS +CG G+ + C R + C RP C
Sbjct: 845 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 904
Query: 719 HGTPCP-PYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ 776
+ PC P W EW +CSRSCG G Q R +QC G V P + RP +
Sbjct: 905 NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARR 964
Query: 777 SCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREA 835
C C W +G+ WSQCS CG G + RQV C N + + E +P + +
Sbjct: 965 PCLRVPCPAQWRLGA-WSQCSATCGEGIQQRQVVC-RTNANSLGHCE----GDRPDTVQV 1018
Query: 836 CDMGPC 841
C + C
Sbjct: 1019 CSLPAC 1024
Score = 98.2 bits (243), Expect = 4e-20
Identities = 79/280 (28%), Positives = 111/280 (39%), Gaps = 40/280 (14%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQP-PSREACDMGPCTT- 843
W + S W+ CS CG G + + C + ++ +P P R C+ PC+
Sbjct: 854 WALKS-WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
Query: 844 AWFHSDWSSKCSAECGT-GIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
W +W + CS CG G+Q R + CL L G ++C G RP R
Sbjct: 913 VWVTEEWGA-CSRSCGKLGVQTRGIQCL-----LPLSNGTHKVMPAKAC-AGDRPEARRP 965
Query: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
C PC WR G W +CS+ CG G Q+R ++C + N S +C RP +
Sbjct: 966 CLRVPCPAQWR--LGAWSQCSATCGEGIQQRQVVCRT------NANSLGHCEG-DRPDTV 1016
Query: 963 QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNS 1022
Q C AC + Q T +V L T + L P K ++
Sbjct: 1017 QVCSLPAC------------GGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKIS-ST 1063
Query: 1023 QPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
+PC+ D S C + V R C P Y CC SC
Sbjct: 1064 EPCTG-------DRSVFCQMEVLDRYCSIPGYHRLCCVSC 1096
Score = 49.3 bits (116), Expect = 2e-05
Identities = 22/57 (38%), Positives = 31/57 (54%)
Query: 30 GHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP 86
GH + E+ G +G W W ++ SCS+ CG GV+ RSR+C P+ L L P
Sbjct: 541 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGP 597
Score = 36.2 bits (82), Expect = 0.17
Identities = 83/344 (24%), Positives = 116/344 (33%), Gaps = 84/344 (24%)
Query: 50 WV--QWASCSQPCG-VGVQRRSRTCQLPTVQ-LHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
WV +W +CS+ CG +GVQ R C LP H +P PEA P + P P
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
Query: 106 TSPETLPLYRTQSRGRG-----GPLRGPASHLG-----REETQEI---RAARRSRLRDPI 152
+ + G G R A+ LG R +T ++ A + +
Sbjct: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1033
Query: 153 KPGMFGYGR-----VPFALPLHRNR----------------------RHPRSPPRSELSL 185
+ ++ G VP + PLH R+ P L
Sbjct: 1034 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1093
Query: 186 ISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTP-SPQAEPLSPETAQTEVAPRT 244
+S + + P+P P P T LPP TP SP P P A P
Sbjct: 1094 VSCIKKASGPNPGPDPGP--------TSLPP----FSTPGSPLPGPQDPADA---AEPPG 1138
Query: 245 RPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRP----- 299
+P H +A T+ P + G +P+ P + SP G P
Sbjct: 1139 KPTGSEDHQHGRA--TQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQ 1196
Query: 300 DPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLS 343
P P VP +GQ G+ D +HPG LP S
Sbjct: 1197 TPTP-VPEDKGQPGE----------------DLRHPGTSLPAAS 1223
Score = 33.9 bits (76), Expect = 0.85
Identities = 52/201 (25%), Positives = 69/201 (34%), Gaps = 38/201 (18%)
Query: 43 PEGVWGPW------VQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALL 96
PEG W P + S ++PC RS CQ+ + + S+P R
Sbjct: 1043 PEGQWVPQSEPLHPINKISSTEPC---TGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKK 1099
Query: 97 PRGQGPRPQTSPETLPLYRTQSRGRGGP------LRGPASHLGREETQEIRAARRSRLRD 150
G P P P +LP + T GP P G E+ Q RA + D
Sbjct: 1100 ASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALD 1159
Query: 151 PIKPGMFGYGRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIP-----SPTPRAEPFS 205
PG + PFA P +P IS +P +PTP E
Sbjct: 1160 TSSPGT----QHPFA---------PETPIPGASWSISPTTPGGLPWGWTQTPTPVPED-- 1204
Query: 206 ANGSPQTEL--PPTELSVHTP 224
G P +L P T L +P
Sbjct: 1205 -KGQPGEDLRHPGTSLPAASP 1224
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 151 bits (382), Expect = 3e-36
Identities = 119/428 (27%), Positives = 165/428 (38%), Gaps = 81/428 (18%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC---AAGARPPASPEPCHGTPCP 724
W++ C+ +CG G C+ + + C +P + C PCP
Sbjct: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
Query: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQCRQE-FGGGGSSVPPERC 766
P WE WT+CS SCG G Q R C +E G V +C
Sbjct: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
Query: 767 GHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVS------- 819
+ P+P + Q+C L C W + WSQC+V CGRG R R V C+ + G+ V
Sbjct: 463 MYAPKPKVMQTCNLFDCPKW-IAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLK 521
Query: 820 ---EQECASGPP------------------QPPSREACDMGPCTTAWFHSDWSSKCSAEC 858
++EC P Q E + + WS+ CS C
Sbjct: 522 LHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSA-CSTTC 580
Query: 859 GTGIQRRSVVCLGSGAALGPGQGEAGAG----TGQSCPTGSRPPDMRACSLGPCER---- 910
G G+Q R V C L Q E G PT RP + AC P R
Sbjct: 581 GPGVQVREVKC---RVLLTFTQTETELPEEECEGPKLPT-ERPCLLEACDESPASRELDI 636
Query: 911 --------TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
T+ W + C++ C G Q +C+ + T+ V + S C + RPPA+
Sbjct: 637 PLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCL-HIQTQQTV-NDSLCDMVHRPPAM 694
Query: 963 -QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQ----LRPSRK 1017
Q C + C RW W PCS +C G QTR+V CL + T PP+ +P
Sbjct: 695 SQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGE---TPAPPEECRDEKPHAL 751
Query: 1018 RPCNSQPC 1025
+ CN C
Sbjct: 752 QACNQFDC 759
Score = 150 bits (380), Expect = 5e-36
Identities = 119/387 (30%), Positives = 156/387 (40%), Gaps = 71/387 (18%)
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEEL---DERSCAAGARPPASPEPCHG 720
P W+ +ACS SCG G+ R F+C+ E+ +E C +P + C+
Sbjct: 418 PLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVM-QTCNL 476
Query: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQC---RQEFGGGGSS----------VPPERC- 766
CP W A EW+ C+ +CG G ++R + C R E GG + V P C
Sbjct: 477 FDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCY 535
Query: 767 ---------GHLPRPNITQSCQLRLCGHWE---VGSPWSQCSVRCGRGQRSRQVRC---- 810
LP Q + E + PWS CS CG G + R+V+C
Sbjct: 536 KPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLL 595
Query: 811 -VGNNGDEVSEQECASGPPQPPSR----EACDMGPC--------------TTAWFHSDWS 851
E+ E+EC GP P R EACD P T W ++ ++
Sbjct: 596 TFTQTETELPEEEC-EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFT 654
Query: 852 SKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDM-RACSLGPCER 910
C+A C G Q VCL C RPP M +AC+ PC
Sbjct: 655 P-CTATCVGGHQEAIAVCLHIQTQQTVNDS--------LCDMVHRPPAMSQACNTEPCPP 705
Query: 911 TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
RW+ G WG CS+ CG G Q RD+ C+ T P C +P ALQ C C
Sbjct: 706 --RWHVGSWGPCSATCGVGIQTRDVYCLHPGETP---APPEECRD-EKPHALQACNQFDC 759
Query: 971 QDRWFSTPWSPCSRSCQGGTQTREVQC 997
W W CSR+C GGTQ R V C
Sbjct: 760 PPGWHIEEWQQCSRTCGGGTQNRRVTC 786
Score = 137 bits (345), Expect = 5e-32
Identities = 89/284 (31%), Positives = 117/284 (41%), Gaps = 30/284 (10%)
Query: 786 WEVGSPWSQCSVRCGR-GQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTA 844
WE G+ WS CS CG G R ++ +CV NG EVSE C E C++ C
Sbjct: 1428 WEPGN-WSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPAR 1486
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
WF S WS +CS CG G R V C + A G + ++C RP + C
Sbjct: 1487 WFTSVWS-QCSVSCGEGYHSRQVTCKRTKA-----NGTVQVVSPRACAPKDRPLGRKPCF 1540
Query: 905 LGPCERTWRWYTGPWGECSSECGSGT---QRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
PC + W P C C Q+R C +S SNC RP
Sbjct: 1541 GHPCVQ-WE----PGNRCPGRCMGRAVRMQQRHTACQHN-------SSDSNCDDRKRPTL 1588
Query: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQ---TLSTRCPPQLRPSRKR 1018
+ C AC W + PW PC+ +C G Q+R+V C+ T C + +P R
Sbjct: 1589 RRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWR 1648
Query: 1019 PCNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
C C D C D++ +C V LC Y CC+SC
Sbjct: 1649 HCLGPSC----DRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
Score = 129 bits (324), Expect = 1e-29
Identities = 88/293 (30%), Positives = 128/293 (43%), Gaps = 28/293 (9%)
Query: 626 EPPLAPAPRP----ARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAY-WKRVGHSACSASC 680
E P P RP A R++ IP P S Y W+ G + C+A+C
Sbjct: 610 EGPKLPTERPCLLEACDESPASRELDIP---------LPEDSETTYDWEYAGFTPCTATC 660
Query: 681 GKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCG 740
G I +C+ ++ + +++ C RPPA + C+ PCPP W G W CS +CG
Sbjct: 661 VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCG 720
Query: 741 PGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-GHWEVGSPWSQCSVRC 799
G Q R + C G + PPE C +P+ Q+C C W + W QCS C
Sbjct: 721 VGIQTRDVYCLHP---GETPAPPEECRD-EKPHALQACNQFDCPPGWHI-EEWQQCSRTC 775
Query: 800 GRGQRSRQVRC--VGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAE 857
G G ++R+V C + +G ++ + P+ S ++C C DW SKCS
Sbjct: 776 GGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDW-SKCSVS 834
Query: 858 CGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCER 910
CG GIQRR VC A +G + C P +R+C + C +
Sbjct: 835 CGVGIQRRKQVCQRLAA-----KGRRIPLSEMMCRDLPGLPLVRSCQMPECSK 882
Score = 122 bits (306), Expect = 2e-27
Identities = 64/197 (32%), Positives = 97/197 (49%), Gaps = 5/197 (2%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G++ + + CS CPP+ D RA QC+A+N ++ G Y+W P + C L C
Sbjct: 108 CEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAP-CALKCH 166
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
+G V KV DGT C + D+C++G C + GCD LGS + D CGVC GD ST
Sbjct: 167 AQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGST 226
Query: 484 CRLVSGNLTDRGGP-LGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
CRLV G P + ++ +P G+ ++I P+ ++ + G G +
Sbjct: 227 CRLVRGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGS---KGEHSF 283
Query: 543 DPPGSYRAGGTVFRYNR 559
+ PG + T + R
Sbjct: 284 NSPGVFLVENTTVEFQR 300
Score = 112 bits (280), Expect = 2e-24
Identities = 97/387 (25%), Positives = 139/387 (35%), Gaps = 79/387 (20%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPAS---------PEPC 718
W + S C+ +CG+G+ + LCI+ GE + G P P PC
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHR-GEHV------GGCNPQLKLHIKEECVIPIPC 534
Query: 719 HG--------TPCPPYWEAGE-----------------WTSCSRSCGPGTQHRQLQCR-- 751
+ P +A E W++CS +CGPG Q R+++CR
Sbjct: 535 YKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVL 594
Query: 752 QEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH--------------------WEVGSP 791
F + +P E C P+ + C L C WE
Sbjct: 595 LTFTQTETELPEEEC-EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAG- 652
Query: 792 WSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDW 850
++ C+ C G + C+ V++ C P +AC+ PC W W
Sbjct: 653 FTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSW 712
Query: 851 SSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCER 910
CSA CG GIQ R V CL G P + C +P ++AC+ C
Sbjct: 713 -GPCSATCGVGIQTRDVYCLHPGETPAP---------PEEC-RDEKPHALQACNQFDCPP 761
Query: 911 TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
W+ W +CS CG GTQ R + C L + P+ + + C C
Sbjct: 762 --GWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDC 819
Query: 971 QDRWFSTPWSPCSRSCQGGTQTREVQC 997
WS CS SC G Q R+ C
Sbjct: 820 PPHLAVGDWSKCSVSCGVGIQRRKQVC 846
Score = 108 bits (269), Expect = 4e-23
Identities = 85/281 (30%), Positives = 111/281 (39%), Gaps = 44/281 (15%)
Query: 660 PLGSPAA---YWKRVGHSACSASCGK---GVWRPIFLCISRESGEELDERSCAAGARPPA 713
P G P +W+ S CSA+CG + RP C+ +G+E+ E C +P A
Sbjct: 1417 PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRP--QCVMA-NGQEVSEALCDHLQKPLA 1473
Query: 714 SPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQC-RQEFGGGGSSVPPERCGHLPRP 772
EPC+ CP W W+ CS SCG G RQ+ C R + G V P C RP
Sbjct: 1474 GFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP 1533
Query: 773 NITQSCQLRLCGHWEVGSPWSQCSVRC-GRGQR--SRQVRCVGNNGDEVSEQECASGPPQ 829
+ C C WE P ++C RC GR R R C N+ D + +
Sbjct: 1534 LGRKPCFGHPCVQWE---PGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDR-----KR 1585
Query: 830 PPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
P R C G C W W C+A CG G Q R V C+ + +
Sbjct: 1586 PTLRRNCTSGACDVCWHTGPW-KPCTAACGRGFQSRKVDCIHT----------------R 1628
Query: 890 SCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGT 930
SC +P R C +WR GP C +C T
Sbjct: 1629 SC----KPVAKRHCVQKKKPISWRHCLGP--SCDRDCTDTT 1663
Score = 103 bits (257), Expect = 9e-22
Identities = 92/328 (28%), Positives = 124/328 (37%), Gaps = 52/328 (15%)
Query: 674 SACSASCGKGVW----RPIFLCISRESGEELDERSCAAGARPPASP---EPCHGTPCPPY 726
SACS +CG GV + L ++ EL E C P P E C +P
Sbjct: 574 SACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRE 633
Query: 727 --------------WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR- 771
WE +T C+ +C G Q C +V C + R
Sbjct: 634 LDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHI--QTQQTVNDSLCDMVHRP 691
Query: 772 PNITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQP 830
P ++Q+C C W VGS W CS CG G ++R V C+ +EC +P
Sbjct: 692 PAMSQACNTEPCPPRWHVGS-WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD--EKP 748
Query: 831 PSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVC---LGSGAALGPG----QGEA 883
+ +AC+ C W +W +CS CG G Q R V C L G+ L QG
Sbjct: 749 HALQACNQFDCPPGWHIEEW-QQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPK 807
Query: 884 GAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGT 943
A + +SC PP + G W +CS CG G QRR +C
Sbjct: 808 -ASSHKSCARTDCPPHLA--------------VGDWSKCSVSCGVGIQRRKQVCQRLAAK 852
Query: 944 EFNV-TSPSNCSHLPRPPALQPCQGQAC 970
+ S C LP P ++ CQ C
Sbjct: 853 GRRIPLSEMMCRDLPGLPLVRSCQMPEC 880
Score = 96.7 bits (239), Expect = 1e-19
Identities = 99/418 (23%), Positives = 154/418 (36%), Gaps = 89/418 (21%)
Query: 722 PCPPYWEAGEWTSCSRSCGPGTQHRQLQC---RQEFGGGGSSVPPERCGHLPRPNITQSC 778
P W ++ C+ +CG G Q +C R + VP C + P N+
Sbjct: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLK-----RVVPDHYCHYYPE-NVKPKP 391
Query: 779 QLRLCG-----------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGNN- 814
+L+ C WE +PW+ CSV CG G + R CV +
Sbjct: 392 KLKECSMDPCPSSDGFKEIMPYDHFQPLPRWE-HNPWTACSVSCGGGIQRRSFVCVEESM 450
Query: 815 -GD--EVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
G+ +V E +C P +P + C++ C W +WS +C+ CG G++ R V+C+
Sbjct: 451 HGEILQVEEWKCMYAP-KPKVMQTCNLFDCPK-WIAMEWS-QCTVTCGRGLRYRVVLCIN 507
Query: 872 S-GAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTG------------- 917
G +G + + C P + P E W
Sbjct: 508 HRGEHVGGCNPQLKLHIKEECVIPI--PCYKPKEKSPVEAKLPWLKQAQELEETRIATEE 565
Query: 918 ------PWGECSSECGSGTQRRDIIC-VSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
PW CS+ CG G Q R++ C V T+ P P+ P +PC +AC
Sbjct: 566 PTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEAC 625
Query: 971 QDR-------------------WFSTPWSPCSRSCQGGTQTREVQCL--STNQTLSTRCP 1009
+ W ++PC+ +C GG Q CL T QT++
Sbjct: 626 DESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC 685
Query: 1010 PQLR--PSRKRPCNSQPCSQR-PDDQCKDSSPHCPLVVQAR--LCVYPYYTATCCRSC 1062
+ P+ + CN++PC R S C + +Q R C++P T C
Sbjct: 686 DMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEEC 743
Score = 43.5 bits (101), Expect = 0.001
Identities = 74/363 (20%), Positives = 120/363 (33%), Gaps = 77/363 (21%)
Query: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-- 783
W+A G+W+ CSR+CG G + +C G ++ + C + P + + + C
Sbjct: 78 WDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSA 137
Query: 784 -------GHW-----EVGSPWSQCSVRC-GRGQRSRQVRCVGNNGDEVSEQECASGPPQP 830
GH+ P + C+++C +GQ N E++ +
Sbjct: 138 YNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQ---------NLVVELAPKVLDGTRCNT 188
Query: 831 PSREACDMGPCTTAWFHSDWSSKCSAE-CGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
S + C G C S + CG VC G G+ +G++ +
Sbjct: 189 DSLDMCISGICQAVGCDRQLGSNAKEDNCG--------VCAGDGSTCRLVRGQSKSHVSP 240
Query: 890 --------SCPTGSRPPDMRACSLGPCERTWRWYT--GPWGECSSECGSGTQRRDIICVS 939
+ P GSR +R GP T G GE S + V
Sbjct: 241 EKREENVIAVPLGSR--SVRITVKGPAHLFIESKTLQGSKGEHSFNSPG------VFLVE 292
Query: 940 KLGTEFNVTSPSNCSHLPRP----------------PALQPCQGQACQDRWFSTPWSPCS 983
EF S +P P +Q Q +W T + PC+
Sbjct: 293 NTTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCT 352
Query: 984 RSCQGGTQTREVQCLSTN------QTLSTRCPPQLRPSRK-RPCNSQPCSQRPDDQCKDS 1036
+C GG Q +C+ P ++P K + C+ PC D K+
Sbjct: 353 VTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPS--SDGFKEI 410
Query: 1037 SPH 1039
P+
Sbjct: 411 MPY 413
Score = 35.4 bits (80), Expect = 0.29
Identities = 12/20 (60%), Positives = 15/20 (75%)
Query: 53 WASCSQPCGVGVQRRSRTCQ 72
W+ CS CGVG+QRR + CQ
Sbjct: 828 WSKCSVSCGVGIQRRKQVCQ 847
Score = 34.3 bits (77), Expect = 0.65
Identities = 12/35 (34%), Positives = 16/35 (45%)
Query: 37 TEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
T + +G W W W+ CS+ CG G R C
Sbjct: 68 TRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRC 102
Score = 33.1 bits (74), Expect = 1.4
Identities = 23/54 (42%), Positives = 24/54 (44%), Gaps = 15/54 (27%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHP-SLPLPPRPPR--HPEAL 95
G WGP CS CGVG+Q R C LHP P PP R P AL
Sbjct: 710 GSWGP------CSATCGVGIQTRDVYC------LHPGETPAPPEECRDEKPHAL 751
Score = 32.0 bits (71), Expect = 3.2
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 4/54 (7%)
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCV-GNN--GDEVSEQECASGPPQPPSRE 834
G+W+ WS CS CG G RC+ G N G + + C S PP E
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTC-SNHDCPPDAE 128
Score = 30.8 bits (68), Expect = 7.2
Identities = 11/19 (57%), Positives = 13/19 (68%)
Query: 53 WASCSQPCGVGVQRRSRTC 71
W +CS CG G+QRRS C
Sbjct: 427 WTACSVSCGGGIQRRSFVC 445
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 149 bits (376), Expect = 1e-35
Identities = 121/453 (26%), Positives = 182/453 (40%), Gaps = 70/453 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G + + R CS CPPE D RA QC+A N + GQ Y+W P + C L C+
Sbjct: 66 CEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQ 124
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
+G V KV DGT C + D+C++G C GCD LGS + D CGVC GD ST
Sbjct: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
Query: 484 CRLVSGNLTDR-GGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
CRLV G + ++ IP G+ +++ P YL + G G ++
Sbjct: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSL 241
Query: 543 DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPG--------VF 594
G++ + + + P + E L GP T I + N G +F
Sbjct: 242 SSTGTFLVDNSSVDFQKFPDK----EILRMAGPLTAD----FIVKIRNSGSADSTVQFIF 293
Query: 595 YQYVI-----------------------SSPPPILENPTPEPPVPQLQPEILRVEPPLAP 631
YQ +I + + N PE ++ +P L
Sbjct: 294 YQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
Query: 632 APRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLC 691
+Q+ +P P PR W+ +ACS+SCG G+ C
Sbjct: 354 CNLDPCPASDGYKQI-MPYDLYHPLPR---------WEATPWTACSSSCGGGIQSRAVSC 403
Query: 692 ISRE---SGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQL 748
+ + ++E C + P + +PC+ CP W A EW+ C+ +CG G ++R +
Sbjct: 404 VEEDIQGHVTSVEEWKCMYTPKMPIA-QPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVV 461
Query: 749 QCRQEFG---GGGSSVPPERCGHLPRPNITQSC 778
C G GG C +P+I + C
Sbjct: 462 LCIDHRGMHTGG--------CSPKTKPHIKEEC 486
Score = 92.0 bits (227), Expect = 3e-18
Identities = 52/169 (30%), Positives = 74/169 (43%), Gaps = 22/169 (13%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC---AAGARPPASPEPCHGTPCP 724
W+ CSA+CG G C S + ++ C +P + C+ PCP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQC-RQEFGGGGSSVPPERC 766
P WEA WT+CS SCG G Q R + C ++ G +SV +C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 767 GHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815
+ P+ I Q C + C W + WS C+V CG+G R R V C+ + G
Sbjct: 421 MYTPKMPIAQPCNIFDCPKW-LAQEWSPCTVTCGQGLRYRVVLCIDHRG 468
Score = 87.0 bits (214), Expect = 8e-17
Identities = 62/204 (30%), Positives = 85/204 (41%), Gaps = 36/204 (17%)
Query: 840 PCTTAWFHSDWSSKCSAECGTGIQRRSVVC--LGSGAALGPGQGEAGAGTGQSC---PTG 894
P W +D+ CSA CG G Q S C L S + Q C P
Sbjct: 296 PIIHRWRETDFFP-CSATCGGGYQLTSAECYDLRSNRVVAD----------QYCHYYPEN 344
Query: 895 SRP-PDMRACSLGPCERTW---------------RWYTGPWGECSSECGSGTQRRDIICV 938
+P P ++ C+L PC + RW PW CSS CG G Q R + CV
Sbjct: 345 IKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCV 404
Query: 939 SKLGTEFNVTSPSN--CSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQ 996
+ + +VTS C + P+ P QPC C +W + WSPC+ +C G + R V
Sbjct: 405 EE-DIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVL 462
Query: 997 CLSTNQTLSTRCPPQLRPSRKRPC 1020
C+ + C P+ +P K C
Sbjct: 463 CIDHRGMHTGGCSPKTKPHIKEEC 486
Score = 52.0 bits (123), Expect = 3e-06
Identities = 37/140 (26%), Positives = 48/140 (34%), Gaps = 29/140 (20%)
Query: 913 RWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPR----PPALQPCQGQ 968
RW + CS+ CG G Q C V + C + P P LQ C
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNR--VVADQYCHYYPENIKPKPKLQECNLD 357
Query: 969 ACQ-----------------DRWFSTPWSPCSRSCQGGTQTREVQCLS------TNQTLS 1005
C RW +TPW+ CS SC GG Q+R V C+
Sbjct: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEE 417
Query: 1006 TRCPPQLRPSRKRPCNSQPC 1025
+C + +PCN C
Sbjct: 418 WKCMYTPKMPIAQPCNIFDC 437
Score = 42.7 bits (99), Expect = 0.002
Identities = 75/342 (21%), Positives = 123/342 (35%), Gaps = 61/342 (17%)
Query: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-G 784
W+A G W+ CSR+CG G + +C G ++ C ++ P + + C
Sbjct: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
Query: 785 HWEV-------------GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
H +V P + CS++C + V E++ +
Sbjct: 96 HNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVV--------ELAPKVLDGTRCYTE 147
Query: 832 SREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSV-VCLGSGAA--LGPGQGEAGAGTG 888
S + C G C C + G+ ++ + VC G G+ L GQ ++
Sbjct: 148 SLDMCISGLCQIV--------GCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
Query: 889 QS------CPTGSRPPDMRACSLGPCERTWRWYT--GPWGECS-SECGSGTQRRDIICVS 939
+S P GSR +R GP T G GE S S G+ +
Sbjct: 200 KSDDTVVAIPYGSR--HIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQ 257
Query: 940 KLGTE--FNVTSPSNCSHLPR-------PPALQPCQGQACQDRWFSTPWSPCSRSCQGGT 990
K + + P + + +Q Q RW T + PCS +C GG
Sbjct: 258 KFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGY 317
Query: 991 QTREVQC--LSTNQTLSTR----CPPQLRPSRK-RPCNSQPC 1025
Q +C L +N+ ++ + P ++P K + CN PC
Sbjct: 318 QLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Score = 33.9 bits (76), Expect = 0.85
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTC 71
+G+W W W+ CS+ CG G R C
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRC 60
Score = 33.1 bits (74), Expect = 1.4
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE 817
G W+ PWS+CS CG G RC+ + E
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
Score = 30.4 bits (67), Expect = 9.4
Identities = 11/27 (40%), Positives = 16/27 (59%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLH 79
W +CS CG G+Q R+ +C +Q H
Sbjct: 385 WTACSSSCGGGIQSRAVSCVEEDIQGH 411
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 144 bits (362), Expect = 6e-34
Identities = 123/442 (27%), Positives = 183/442 (41%), Gaps = 35/442 (7%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQL-YQWEPFTEVQGSQRCELNC 422
CSG + + CS+ CP D R QC ++ G + W P +RC L C
Sbjct: 600 CSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYC 659
Query: 423 RPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
R V V DGT C A +CV G C GCDG++GS ++ D CGVCGGD+
Sbjct: 660 ESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDN 719
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRG-PGGRSIINGNW 540
S C++V G T GY K+ IPAGA L I ++ +S++LA++ G+ I+N
Sbjct: 720 SHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEEN 779
Query: 541 AVDPPG-SYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMI-FQEENPGVFYQYV 598
VD ++ A G + Y R+E E+L GP + V +I + + Y+Y+
Sbjct: 780 DVDASSKTFIAMGVEWEY----RDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYM 835
Query: 599 ISSPP-PILENPTPEPPVPQLQPEILRVEPPLAPAPRPAR-TPGTLQRQV---------- 646
I + +N E + + + P P ++ T +R++
Sbjct: 836 IHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFC 895
Query: 647 -RIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGK-GVWRPIFLCIS---RESGEELD 701
+ + A P W CS +CG+ G+ CI + +
Sbjct: 896 AALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVH 955
Query: 702 ERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSV 761
+ C P S C CP W AG W+ CS +CG GTQ R + CR G
Sbjct: 956 AKHC--NDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGIC- 1012
Query: 762 PPERCGHLPRPNITQSCQLRLC 783
RP ++C+L C
Sbjct: 1013 ------QEERPETARTCRLGPC 1028
Score = 95.5 bits (236), Expect = 2e-19
Identities = 74/249 (29%), Positives = 93/249 (37%), Gaps = 44/249 (17%)
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
W WS CS CG G Q C L G S P R RAC+
Sbjct: 858 WALKKWSP-CSKPCGGGSQFTKYGCR---RRLDHKMVHRGFCAALSKPKAIR----RACN 909
Query: 905 LGPCERTWRWYTGPWGECSSECG-SGTQRRDIICVSKLGTEFNVTSPSNCSHL--PRPPA 961
C + W TG W CS CG +G Q R + C+ L N T + H RP +
Sbjct: 910 PQECSQPV-WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHD--NTTRSVHAKHCNDARPES 966
Query: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCN 1021
+ C + C RW + PWS CS +C GTQ R V C + + + C + RP R C
Sbjct: 967 RRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGI-CQEE-RPETARTCR 1024
Query: 1022 SQPCSQRPDDQCK----------------------------DSSPHCPLVVQARLCVYPY 1053
PC + D K D S C + V +R C P
Sbjct: 1025 LGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPG 1084
Query: 1054 YTATCCRSC 1062
Y CC+SC
Sbjct: 1085 YNKLCCKSC 1093
Score = 94.4 bits (233), Expect = 5e-19
Identities = 60/179 (33%), Positives = 83/179 (46%), Gaps = 13/179 (7%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP-PY 726
W S CS CG G + C R + + CAA ++P A C+ C P
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
Query: 727 WEAGEWTSCSRSCG-PGTQHRQLQCRQEFGGGGS-SVPPERCGHLPRPNITQSCQLRLC- 783
W GEW CS++CG G Q R ++C Q + SV + C RP ++C LC
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRC-VGNNGDEVSEQECASGPPQPPSREACDMGPC 841
G W G PWSQCSV CG G + R V C ++ + ++E +P + C +GPC
Sbjct: 977 GRWRAG-PWSQCSVTCGNGTQERPVLCRTADDSFGICQEE------RPETARTCRLGPC 1028
Score = 92.0 bits (227), Expect = 3e-18
Identities = 63/192 (32%), Positives = 81/192 (42%), Gaps = 27/192 (14%)
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN-ITQSCQLRLCGH 785
W +W+ CS+ CG G+Q + CR+ V C L +P I ++C + C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDH--KMVHRGFCAALSKPKAIRRACNPQECSQ 915
Query: 786 --WEVGSPWSQCSVRCGR-GQRSRQVRCV----GNNGDEVSEQECASGPPQPPSREACDM 838
W G W CS CGR G + R VRC+ N V + C P+ SR AC
Sbjct: 916 PVWVTGE-WEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPE--SRRACSR 972
Query: 839 GPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPP 898
C W W S+CS CG G Q R V+C + + G Q E RP
Sbjct: 973 ELCPGRWRAGPW-SQCSVTCGNGTQERPVLCRTADDSFGICQEE-------------RPE 1018
Query: 899 DMRACSLGPCER 910
R C LGPC R
Sbjct: 1019 TARTCRLGPCPR 1030
Score = 63.5 bits (153), Expect = 1e-09
Identities = 39/134 (29%), Positives = 62/134 (46%), Gaps = 14/134 (10%)
Query: 912 WRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL-QPCQGQAC 970
+ W W CS CG G+Q C +L + + C+ L +P A+ + C Q C
Sbjct: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRL--DHKMVHRGFCAALSKPKAIRRACNPQEC 913
Query: 971 -QDRWFSTPWSPCSRSC-QGGTQTREVQCL-----STNQTLSTRCPPQLRPSRKRPCNSQ 1023
Q W + W PCS++C + G Q R V+C+ +T +++ + RP +R C+ +
Sbjct: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRE 973
Query: 1024 PCSQR----PDDQC 1033
C R P QC
Sbjct: 974 LCPGRWRAGPWSQC 987
Score = 41.2 bits (95), Expect = 0.005
Identities = 17/38 (44%), Positives = 23/38 (60%), Gaps = 4/38 (10%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPS 81
+G WG W + SCS+ CG GV+ R+R C P HP+
Sbjct: 561 DGSWGAWSPFGSCSRTCGTGVKFRTRQCDNP----HPA 594
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 141 bits (356), Expect = 3e-33
Identities = 101/323 (31%), Positives = 143/323 (44%), Gaps = 52/323 (16%)
Query: 281 PRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGT------GGTPHGPR--LEPDP 332
P S+G P+ RP P G GPWG GG R +P+P
Sbjct: 503 PGHLCSEGSCLPEEEVERPKPVAD----GGWAPWGPWGECSRTCGGGVQFSHRECKDPEP 558
Query: 333 QHPGAWLPLLSNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCA 392
Q+ G + C G + ++C CPP+ R QC
Sbjct: 559 QNGGRY-------------------------CLGRRAKYQSCHTEECPPDGKSFREQQCE 593
Query: 393 AFNSQEFM---GQLYQWEP-FTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAP 448
+N+ + G L QW P + V RC+L CR RG + KV DGTLC P
Sbjct: 594 KYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETL 653
Query: 449 DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPA 508
ICV G+C+ GCD ++ S R+ D CGVCGG ++CR VSG+LT GY I+ IPA
Sbjct: 654 AICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTN--YGYNDIVTIPA 711
Query: 509 GALRLQIAQ-----LRPSSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPR 562
GA + + Q ++ NYLAL+ G+ ++NGN A+ GT+ +Y+
Sbjct: 712 GATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYS---G 768
Query: 563 EEGKGESLSAEGPTTQPVDVYMI 585
E L + P +P+ V ++
Sbjct: 769 SIATLERLQSFRPLPEPLTVQLL 791
Score = 49.3 bits (116), Expect = 2e-05
Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 5/58 (8%)
Query: 913 RWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
+W G W ECSS CG+G QRR + C G + + C+ +P +PC+ Q C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSG-----QASATCNKALKPEDAKPCESQLC 887
Score = 47.8 bits (112), Expect = 6e-05
Identities = 20/53 (37%), Positives = 26/53 (49%)
Query: 973 RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPC 1025
+W WS CS +C G Q R V+C + S C L+P +PC SQ C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 45.1 bits (105), Expect = 4e-04
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 5/57 (8%)
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
W G+W+ CS +CG G Q R ++CR G ++ C +P + C+ +LC
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT-----CNKALKPEDAKPCESQLC 887
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/46 (43%), Positives = 24/46 (52%), Gaps = 4/46 (8%)
Query: 36 PTEEGQGP----EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
P EE + P +G W PW W CS+ CG GVQ R C+ P Q
Sbjct: 514 PEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQ 559
Score = 37.0 bits (84), Expect = 0.10
Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 12/64 (18%)
Query: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
W DWS +CS+ CG G QRR+V C G+A A +C +P D + C
Sbjct: 836 WVLGDWS-ECSSTCGAGWQRRTVECRDP-------SGQASA----TCNKALKPEDAKPCE 883
Query: 905 LGPC 908
C
Sbjct: 884 SQLC 887
Score = 35.8 bits (81), Expect = 0.22
Identities = 29/102 (28%), Positives = 38/102 (37%), Gaps = 19/102 (18%)
Query: 831 PSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQS 890
P+ A D+ C W H+D + +C +L P G G
Sbjct: 464 PNTSAQDV--CAQLWCHTDGAEP--------------LCHTKNGSL-PWADGTPCGPGHL 506
Query: 891 CPTGSRPPDMRACSLGP-CERTWRWYTGPWGECSSECGSGTQ 931
C GS P+ P + W + GPWGECS CG G Q
Sbjct: 507 CSEGSCLPEEEVERPKPVADGGWAPW-GPWGECSRTCGGGVQ 547
Score = 32.3 bits (72), Expect = 2.5
Identities = 14/30 (46%), Positives = 18/30 (60%), Gaps = 2/30 (6%)
Query: 50 WV--QWASCSQPCGVGVQRRSRTCQLPTVQ 77
WV W+ CS CG G QRR+ C+ P+ Q
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQ 865
Score = 31.6 bits (70), Expect = 4.2
Identities = 16/41 (39%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 775 TQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815
T Q L W +G WS+CS CG G + R V C +G
Sbjct: 825 TNIIQPLLHAQWVLGD-WSECSSTCGAGWQRRTVECRDPSG 864
Score = 30.4 bits (67), Expect = 9.4
Identities = 34/136 (25%), Positives = 44/136 (32%), Gaps = 16/136 (11%)
Query: 625 VEPPLAPAPRPARTPGTL---QRQVRIPQMPAPPHPRTPLGSP----AAYWKRV--GHSA 675
++ P A P P PG + Q + Q+ P P S A W
Sbjct: 426 LDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPL 485
Query: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSC 735
C G W C G E SC P+P P+ G W C
Sbjct: 486 CHTKNGSLPWADGTPC---GPGHLCSEGSCLP-EEEVERPKPVADGGWAPW---GPWGEC 538
Query: 736 SRSCGPGTQHRQLQCR 751
SR+CG G Q +C+
Sbjct: 539 SRTCGGGVQFSHRECK 554
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.459
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,053,021
Number of Sequences: 37866
Number of extensions: 4574372
Number of successful extensions: 33632
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 178
Number of HSP's successfully gapped in prelim test: 1431
Number of HSP's that attempted gapping in prelim test: 20685
Number of HSP's gapped (non-prelim): 11106
length of query: 1074
length of database: 18,247,518
effective HSP length: 113
effective length of query: 961
effective length of database: 13,968,660
effective search space: 13423882260
effective search space used: 13423882260
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.