Search of human proteins with 34734071

Search of human proteins with 34734071

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
         (452 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre...   899   0.0  
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...   346   2e-95
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is...   343   2e-94
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...   342   4e-94
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso...   340   2e-93
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...   330   2e-90
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...   324   1e-88
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom...   311   6e-85
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec...   306   3e-83
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom...   299   3e-81
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   291   8e-79
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]       289   4e-78
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]       288   5e-78
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]         288   5e-78
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]       286   3e-77
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   285   5e-77
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo...   285   8e-77
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]       284   1e-76
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo...   283   3e-76
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...   278   6e-75
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]       271   9e-73
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso...   266   3e-71
gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform...   264   1e-70
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ...   263   3e-70
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr...   257   2e-68
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs...   249   3e-66
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...   249   5e-66
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...   249   5e-66
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso...   249   5e-66
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ...   245   5e-65

>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
           precursor [Homo sapiens]
          Length = 452

 Score =  899 bits (2324), Expect = 0.0
 Identities = 452/452 (100%), Positives = 452/452 (100%)

Query: 1   MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIG 60
           MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIG
Sbjct: 1   MDAPARLLAPLLLLCAQQLRGTRAMNDIGDYVGSNLEISWLPNLDGLIAGYARNFRPGIG 60

Query: 61  GPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLW 120
           GPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLW
Sbjct: 61  GPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLW 120

Query: 121 LPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECML 180
           LPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECML
Sbjct: 121 LPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECML 180

Query: 181 DLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLH 240
           DLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLH
Sbjct: 181 DLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLH 240

Query: 241 FHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSS 300
           FHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSS
Sbjct: 241 FHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSS 300

Query: 301 LPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAI 360
           LPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAI
Sbjct: 301 LPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRAEMDVRNAI 360

Query: 361 VLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR 420
           VLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR
Sbjct: 361 VLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLR 420

Query: 421 PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM 452
           PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM
Sbjct: 421 PIDADTIDIYARAVFPAAFAAVNVIYWAAYAM 452


>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score =  346 bits (888), Expect = 2e-95
 Identities = 182/436 (41%), Positives = 270/436 (61%), Gaps = 33/436 (7%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           +D L+ GY    RP  GGPPV+V + ++VASID +SE NM+YT+T++  QSW+D RLSY+
Sbjct: 41  VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
                L LD+R  D+LW+PDT+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C MDL +YP+DEQ C L++ESYGY+++DI +YW+  +  + G++K++L QF+I  Y+  +
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVS 220

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
           + + F + G +PRLSL F L+RN G +I+Q+YMPS L+  +SWVSFWI+  A  ARV+LG
Sbjct: 221 KKVEF-TTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALG 279

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQK- 342
           ITTVLTMTT+    R +LP+   +KA+D+Y   C+VFVF AL+EYAF ++    +  QK 
Sbjct: 280 ITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKK 339

Query: 343 ----------AKVKVSRPRAEMDVRNAIVLFSLSAAGVT--QELAISRRQRRVPGNLMGS 390
                      K K+   + ++D    I+L +L     T   E+  S      P   M S
Sbjct: 340 GASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSD---PKATMYS 396

Query: 391 YRSVGVETGE--TKKEGAARS------GGQGGIRARLRPI--------DADTIDIYARAV 434
           Y S  ++  +  + +E   R+        +G IR R   +        D ++ID ++R  
Sbjct: 397 YDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMF 456

Query: 435 FPAAFAAVNVIYWAAY 450
           FP  F+  NV+YW  Y
Sbjct: 457 FPITFSLFNVVYWLYY 472


>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 2 precursor [Homo sapiens]
          Length = 473

 Score =  343 bits (879), Expect = 2e-94
 Identities = 194/476 (40%), Positives = 291/476 (61%), Gaps = 44/476 (9%)

Query: 7   LLAPLLLLCAQQLRGT--RAMNDIGDYVGSNLEISWLPN-LDGLIAGYARNFRPGIGGPP 63
           LL P+ L      RG+  R++ND G+       +S++   +D L+ GY    RP  GGPP
Sbjct: 8   LLLPIWLSWTLGTRGSEPRSVNDPGN-------MSFVKETVDKLLKGYDIRLRPDFGGPP 60

Query: 64  VNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPD 123
           V V + +++ASID +SE NM+YT+T++  Q WRD RL+Y+     L LD+R  D+LW+PD
Sbjct: 61  VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120

Query: 124 TFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLE 183
           T+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T AC MDL +YP+DEQ C L++E
Sbjct: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180

Query: 184 SYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHL 243
           SYGY+++DI +YW    + + G+++++L QF+I  +R  +  + F + G +PRLSL F L
Sbjct: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF-ATGAYPRLSLSFRL 239

Query: 244 RRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPR 303
           +RN G +I+Q+YMPS+L+  +SWVSFWI+  A  ARV+LGITTVLTMTT+    R +LP+
Sbjct: 240 KRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPK 299

Query: 304 ASAIKALDVYFWICYVFVFAALVEYAFAHF----NADYRKK----QKAKVKVSRPRAE-- 353
              +KA+D+Y   C+VFVF AL+EYAF ++        R+K    + AK K  R ++E  
Sbjct: 300 IPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESN 359

Query: 354 -MDVRNAIVLFSL----------SAAGVTQELAIS-------RRQRRVPGNLMGSYRSVG 395
            +D    I+L SL             G T+  AIS        R++ +P    G  R +G
Sbjct: 360 RVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPRE--GHGRFLG 417

Query: 396 VETGETKKEGAARSGGQGGIRARLRPI-DADTIDIYARAVFPAAFAAVNVIYWAAY 450
             +   KK    R   Q  ++ ++  + D + ID ++R VFP  F+  N++YW  Y
Sbjct: 418 DRSLPHKKTHLRRRSSQ--LKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYY 471


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score =  342 bits (877), Expect = 4e-94
 Identities = 183/437 (41%), Positives = 263/437 (60%), Gaps = 34/437 (7%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           +D L+ GY    RP  GGPPV V + +++ASID +SE NM+YT+T++  Q+WRD RLSYN
Sbjct: 40  VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
                L LD+R  D+LW+PDT+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C MDL +YP+DEQ C L++ESYGY+++DI +YW      + G+ K++L QF+I  Y+  T
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
           + + F S G +PRLSL F L+RN G +I+Q+YMPS+L+  +SWVSFWI+  A  ARV+LG
Sbjct: 220 KKVVF-STGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALG 278

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYA---FAHFNADYRKK 340
           ITTVLTMTT+    R +LP+   +KA+D+Y   C+VFVF AL+EYA   +  F    +++
Sbjct: 279 ITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQ 338

Query: 341 QKAKVKVSRPRAE--------MDVRNAIVLFSLSAAGVTQELAISRRQRRV--PGNLMGS 390
           +KA  K +    E        MD    I+L +L    +  E+A S     +  P + M +
Sbjct: 339 KKAAEKAASANNEKMRLDVNKMDPHENILLSTLE---IKNEMATSEAVMGLGDPRSTMLA 395

Query: 391 -------YRSVGVETGETKKEGAARSGGQGGIRARLRP----------IDADTIDIYARA 433
                  YR  G+      +    R   Q   R R R            D + ID ++R 
Sbjct: 396 YDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRI 455

Query: 434 VFPAAFAAVNVIYWAAY 450
            FP  F+  N++YW  Y
Sbjct: 456 FFPVVFSFFNIVYWLYY 472


>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 1 precursor [Homo sapiens]
          Length = 473

 Score =  340 bits (872), Expect = 2e-93
 Identities = 183/436 (41%), Positives = 272/436 (62%), Gaps = 34/436 (7%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           +D L+ GY    RP  GGPPV V + +++ASID +SE NM+YT+T++  Q WRD RL+Y+
Sbjct: 41  VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
                L LD+R  D+LW+PDT+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C MDL +YP+DEQ C L++ESYGY+++DI +YW    + + G+++++L QF+I  +R  +
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVS 220

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
             + F + G +PRLSL F L+RN G +I+Q+YMPS+L+  +SWVSFWI+  A  ARV+LG
Sbjct: 221 RNVVF-ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALG 279

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF----NADYRK 339
           ITTVLTMTT+    R +LP+   +KA+D+Y   C+VFVF AL+EYAF ++        R+
Sbjct: 280 ITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQ 339

Query: 340 K----QKAKVKVSRPRAE---MDVRNAIVLFSL----------SAAGVTQELAIS----- 377
           K    + AK K  R ++E   +D    I+L SL             G T+  AIS     
Sbjct: 340 KKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSG 399

Query: 378 --RRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLRPI-DADTIDIYARAV 434
              R++ +P    G  R +G  +   KK    R   Q  ++ ++  + D + ID ++R V
Sbjct: 400 IQYRKQSMPRE--GHGRFLGDRSLPHKKTHLRRRSSQ--LKIKIPDLTDVNAIDRWSRIV 455

Query: 435 FPAAFAAVNVIYWAAY 450
           FP  F+  N++YW  Y
Sbjct: 456 FPFTFSLFNLVYWLYY 471


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score =  330 bits (846), Expect = 2e-90
 Identities = 179/411 (43%), Positives = 257/411 (62%), Gaps = 21/411 (5%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           +D L+ GY    RP  GGPPV V + +++ASID +SE NM+YT+T++  Q+WRD RLSYN
Sbjct: 40  VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
                L LD+R  D+LW+PDT+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C MDL +YP+DEQ C L++ESYGY+++DI +YW      + G+ K++L QF+I  Y+  T
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
           + + F S G +PRLSL F L+RN G +I+Q+YMPS+L+  +SWVSFWI+  A  ARV+LG
Sbjct: 220 KKVVF-STGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALG 278

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYA---FAHFNADYRKK 340
           ITTVLTMTT+    R +LP+   +KA+D+Y   C+VFVF AL+EYA   +  F    +++
Sbjct: 279 ITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQ 338

Query: 341 QKAKVKVSRPRAE---MDVRNAIVLFSLSAAGV--------TQELAISRRQRRVPGNL-- 387
           +KA  K +    E   +DV N I    +   G         T  L+ +RR      +L  
Sbjct: 339 KKAAEKAASANNEKMRLDV-NKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYT 397

Query: 388 MGSYRSVGVETGETKKEGAARSG--GQGGIRARLRPIDADTIDIYARAVFP 436
           M  + ++ + T E K E A      G G  R+ +   DA +I  Y +A  P
Sbjct: 398 MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQ-YRKAGLP 447


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score =  324 bits (830), Expect = 1e-88
 Identities = 179/420 (42%), Positives = 263/420 (62%), Gaps = 13/420 (3%)

Query: 32  VGSNLEISWLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFL 91
           VG + ++S LP  + L AGY +  RP  GG PV +AL L++ASI  ISE+NM+YT T++L
Sbjct: 30  VGRSDKLS-LPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYL 88

Query: 92  HQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGV 151
            Q W D RL +   N++  LD+R V+ LW+PDT+IV +K ++ H+VTV N+LIRL  +G 
Sbjct: 89  RQRWMDQRLVFEG-NKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGT 147

Query: 152 ILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQL 211
           +LY++RIT+TVAC+MDL+KYPMD Q C L LES+GY   D+ + W    + + GL+ L+L
Sbjct: 148 VLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRL 207

Query: 212 AQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWI 271
           AQ+TI  Y FT    + +  G + RL L F LRRN   +I+++Y+PS  LV +SWVSFWI
Sbjct: 208 AQYTIERY-FTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWI 266

Query: 272 SQAAVPARVSLGITTVLTMTTLMVSARSSLPRASA-IKALDVYFWICYVFVFAALVEYAF 330
           S  +VPAR  +G+TTVL+MTTLM+ +R+SLP  +  IKA+DVY  IC+ FVF AL+EYA 
Sbjct: 267 SLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAV 326

Query: 331 AHFNADYRKKQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGS 390
           AH+++  +   K +   ++   E+ + N I+  S+S+     +  IS     +  + +  
Sbjct: 327 AHYSSLQQMAAKDR-GTTKEVEEVSITN-IINSSISSF----KRKISFASIEISSDNV-D 379

Query: 391 YRSVGVETGETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
           Y  + ++T +  K         G I       +   +D Y++ +FP  F   NV YWA Y
Sbjct: 380 YSDLTMKTSDKFKFVFREK--MGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYY 437


>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
           sapiens]
          Length = 479

 Score =  311 bits (798), Expect = 6e-85
 Identities = 153/401 (38%), Positives = 247/401 (61%), Gaps = 11/401 (2%)

Query: 54  NFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNE-TLGLD 112
           + RPG GGP + V + ++V S+D ISE +M++TMT++L   W+D RLS+  TN  ++  D
Sbjct: 87  SMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFD 146

Query: 113 SRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYP 172
            R V K+W+PD F V++K ++ HD T +N ++R+QPDG +LYS+R+T T  C+MD +++P
Sbjct: 147 GRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFP 206

Query: 173 MDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAG 232
           +D Q C L++ESY Y+ +D++ YW +  + +   +++ L+QF I  +  TT+L  + S G
Sbjct: 207 LDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTG 266

Query: 233 QFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTT 292
            + RL ++F LRR+   +++Q+Y P+ L+V +SWVSFWI + AVPARV LGITTVLTM+T
Sbjct: 267 WYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMST 326

Query: 293 LMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF--NADYRKKQKAKVKVSRP 350
           ++    +S+PR S IKA+D+Y W+ +VFVF +++EYA  ++      RK+QK + K+   
Sbjct: 327 IITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCT 386

Query: 351 RAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSG 410
                 R A++  + S   V             P  +M       V+     +  + +  
Sbjct: 387 SGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMM-------VQLTLASERSSPQRK 439

Query: 411 GQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAYA 451
            Q      +R ID   ID Y+R +FPAA+   N+IYW+ ++
Sbjct: 440 SQRSSYVSMR-IDTHAIDKYSRIIFPAAYILFNLIYWSIFS 479


>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
           precursor [Homo sapiens]
          Length = 490

 Score =  306 bits (783), Expect = 3e-83
 Identities = 150/407 (36%), Positives = 255/407 (62%), Gaps = 17/407 (4%)

Query: 54  NFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNH-TNETLGLD 112
           + RP  GGP + V + ++V S+D ISE +M++TMT++L   W+D RL+++  +N+++  D
Sbjct: 92  SMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFD 151

Query: 113 SRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYP 172
            R V K+W+PD F V++K ++ HD T +N ++R+ PDG +LYS+RIT T  C+MD + +P
Sbjct: 152 GRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFP 211

Query: 173 MDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAG 232
           +D Q C L+LESY Y+ ED++ YW    E +   +K+ L+QF I  +  T+ L  + S G
Sbjct: 212 LDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTG 271

Query: 233 QFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTT 292
            + RL ++F LRR+   +++Q+Y P+ L+V +SWVSFWI + AVPARVSLGITTVLTMTT
Sbjct: 272 WYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTT 331

Query: 293 LMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSRPRA 352
           ++    +S+PR S +KA+D+Y W+ +VFVF +++EYA  ++    +++++ K++   P  
Sbjct: 332 IITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCM 391

Query: 353 EMDVRNAIVLF--------SLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKE 404
              + +  ++         + S AG  +   ++  +R+   + +  +  +  E    +K+
Sbjct: 392 CGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQ---DKIVVHLGLSGEANAARKK 448

Query: 405 GAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAYA 451
           G  +  GQ G R      +   ID Y+R +FPA++   N+IYW+ ++
Sbjct: 449 GLLK--GQTGFRIFQ---NTHAIDKYSRLIFPASYIFFNLIYWSVFS 490


>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
           sapiens]
          Length = 467

 Score =  299 bits (766), Expect = 3e-81
 Identities = 151/398 (37%), Positives = 240/398 (60%), Gaps = 9/398 (2%)

Query: 56  RPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHT-NETLGLDSR 114
           RPG GG PV V + + V SID ISE NM++TMT +L   W+D RLS+  T N+++  D R
Sbjct: 75  RPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHR 134

Query: 115 FVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMD 174
              K+W+PD F V++K ++ HD T+EN ++R+ PDG +L S+RIT +  C MD +++P+D
Sbjct: 135 LTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLD 194

Query: 175 EQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQF 234
            Q C L+LESY Y+ +D++ YW    + ++  + + L+QF I  +  ++ L  + S G +
Sbjct: 195 TQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWY 254

Query: 235 PRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLM 294
            RL ++F LRR+   +++Q+Y P++L+V +SWVSFWI + AVPARVSLGITTVLTM+T++
Sbjct: 255 NRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTII 314

Query: 295 VSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF--NADYRKKQKAKVKVSRPRA 352
            +  +S+P+ S +KA+DVY W+  +FVF +++EYA  ++    + RK+ K   K+SR   
Sbjct: 315 TAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISR--- 371

Query: 353 EMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQ 412
              + N   + +++  G   +  I   Q  +  N     R   + +  T      R    
Sbjct: 372 ---MYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSL 428

Query: 413 GGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
           GG   R+   +   ID Y+R +FP  +   N+ YW  Y
Sbjct: 429 GGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466


>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
           precursor [Homo sapiens]
          Length = 467

 Score =  291 bits (745), Expect = 8e-79
 Identities = 160/408 (39%), Positives = 230/408 (56%), Gaps = 14/408 (3%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           L+ L+ GY    RP IG  P  +   + V SI  ++  NMEYT+ +F  Q+W D RL +N
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
            T + L L+S  V K+W+PDTF  N+K A  H +T  N+++R+  DG +LY++R+T    
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C + L  +PMDE  C L+  SYGY  E+IVY W  S   +      +L QF+    R TT
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
           E++   ++G +  +S++F L R  G + IQ+Y+P  L+V +SWVSFWI++ AVPAR SLG
Sbjct: 250 EVVK-TTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLG 308

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKA 343
           ITTVLTMTTL   AR SLP+ S + A+D++  +C++FVF+ALVEY   H+    RK  K 
Sbjct: 309 ITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKD 368

Query: 344 KVKVSR-PRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETK 402
           K K  + P   +D+R       ++ A   QE         + G    S+        E  
Sbjct: 369 KDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFC----CFEDC 424

Query: 403 KEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
           + GA R    G I  R+  +D+     YAR  FP AF   N++YW +Y
Sbjct: 425 RTGAWR---HGRIHIRIAKMDS-----YARIFFPTAFCLFNLVYWVSY 464


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score =  289 bits (739), Expect = 4e-78
 Identities = 160/415 (38%), Positives = 236/415 (56%), Gaps = 24/415 (5%)

Query: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99
           +L  L G  +GY    RP   GPPVNV   + + S   I+E  M+Y + +FL Q W DSR
Sbjct: 47  FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSR 106

Query: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158
           L+Y+ + +++L LD   +D +W PD F  N K A FHDVT +NKL+R+  +G +LYSIR+
Sbjct: 107 LAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRL 166

Query: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218
           T T++C MDL  +PMD Q C + LES+GY+  D+++ W  S   +   + L L QF +  
Sbjct: 167 TLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWL-SDGPVQVAEGLTLPQFILKE 225

Query: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
            +         + G+F  + + FHL R  G Y+IQ Y+PS+L+V +SWVSFWI+  A PA
Sbjct: 226 EKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPA 285

Query: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF-NADY 337
           RV+LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVFAAL+EYA  +F +  +
Sbjct: 286 RVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQH 345

Query: 338 RKKQKAKVKVSRPRAEMDV-RNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGV 396
           ++  + + +  R   E DV R +   FS    G   ++      +  P N +        
Sbjct: 346 KEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPL-------- 397

Query: 397 ETGETKKEGAARSGGQGGIRARLRPID-ADTIDIYARAVFPAAFAAVNVIYWAAY 450
              +  K+G A          + + +D A  ID  +RA FP AF   N+ YW  Y
Sbjct: 398 --PQPPKDGDA---------IKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  288 bits (738), Expect = 5e-78
 Identities = 159/415 (38%), Positives = 236/415 (56%), Gaps = 24/415 (5%)

Query: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99
           +L  L G  +GY    RP   GPPVNV   + + S   ++E  M+Y + +FL Q W DSR
Sbjct: 47  FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSR 106

Query: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158
           L+Y+ + +++L LD   +D +W PD F  N K A FHDVT +NKL+R+  +G +LYSIR+
Sbjct: 107 LAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRL 166

Query: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218
           T T++C MDL  +PMD Q C + LES+GY+  D+++ W  S   +   + L L QF +  
Sbjct: 167 TLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWL-SDGPVQVAEGLTLPQFILKE 225

Query: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
            +         + G+F  + + FHL R  G Y+IQ Y+PS+L+V +SWVSFWI+  A PA
Sbjct: 226 EKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPA 285

Query: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF-NADY 337
           RV+LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVFAAL+EYA  +F +  +
Sbjct: 286 RVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQH 345

Query: 338 RKKQKAKVKVSRPRAEMDV-RNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGV 396
           ++  + + +  R   E DV R +   FS    G   ++      +  P N +        
Sbjct: 346 KEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPL-------- 397

Query: 397 ETGETKKEGAARSGGQGGIRARLRPID-ADTIDIYARAVFPAAFAAVNVIYWAAY 450
              +  K+G A          + + +D A  ID  +RA FP AF   N+ YW  Y
Sbjct: 398 --PQPPKDGDA---------IKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  288 bits (738), Expect = 5e-78
 Identities = 159/415 (38%), Positives = 236/415 (56%), Gaps = 24/415 (5%)

Query: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99
           +L  L G  +GY    RP   GPPVNV   + + S   ++E  M+Y + +FL Q W DSR
Sbjct: 47  FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSR 106

Query: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158
           L+Y+ + +++L LD   +D +W PD F  N K A FHDVT +NKL+R+  +G +LYSIR+
Sbjct: 107 LAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRL 166

Query: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218
           T T++C MDL  +PMD Q C + LES+GY+  D+++ W  S   +   + L L QF +  
Sbjct: 167 TLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWL-SDGPVQVAEGLTLPQFILKE 225

Query: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
            +         + G+F  + + FHL R  G Y+IQ Y+PS+L+V +SWVSFWI+  A PA
Sbjct: 226 EKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPA 285

Query: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF-NADY 337
           RV+LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVFAAL+EYA  +F +  +
Sbjct: 286 RVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQH 345

Query: 338 RKKQKAKVKVSRPRAEMDV-RNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGV 396
           ++  + + +  R   E DV R +   FS    G   ++      +  P N +        
Sbjct: 346 KEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPL-------- 397

Query: 397 ETGETKKEGAARSGGQGGIRARLRPID-ADTIDIYARAVFPAAFAAVNVIYWAAY 450
              +  K+G A          + + +D A  ID  +RA FP AF   N+ YW  Y
Sbjct: 398 --PQPPKDGDA---------IKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441


>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
          Length = 464

 Score =  286 bits (732), Expect = 3e-77
 Identities = 156/421 (37%), Positives = 236/421 (56%), Gaps = 25/421 (5%)

Query: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99
           +L  L G  +GY    RP   GPPVNV   + + S   I+E  M+Y + +FL Q W D R
Sbjct: 46  FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPR 105

Query: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158
           L+Y+ + +++L LD   +D +W PD F  N K A FH+VT +NKL+R+  +G +LYSIR+
Sbjct: 106 LAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRL 165

Query: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218
           T T++C MDL  +PMD Q C++ LES+GY+  D+++ W + +  +   + L L QF +  
Sbjct: 166 TLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQD-EAPVQVAEGLTLPQFLLKE 224

Query: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
            +         + G+F  + + FHL R  G Y+IQ Y+PS+L+V +SWVSFWI+  A PA
Sbjct: 225 EKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPA 284

Query: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYR 338
           RV+LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVF+AL+EYA  +F     
Sbjct: 285 RVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNF---VS 341

Query: 339 KKQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVET 398
           ++ K  ++  R R     +N    F+L       ++    R+ R       S+ + G+  
Sbjct: 342 RQHKELLRFRRKR-----KNKTEAFALEKFYRFSDMDDEVRESRF------SFTAYGMGP 390

Query: 399 GETKKEGAARSGGQGGIRARLRPID---------ADTIDIYARAVFPAAFAAVNVIYWAA 449
               K+G    G    ++   +  D         A  ID  +RA FP AF   N+ YW  
Sbjct: 391 CLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVI 450

Query: 450 Y 450
           Y
Sbjct: 451 Y 451


>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
           precursor [Homo sapiens]
          Length = 475

 Score =  285 bits (730), Expect = 5e-77
 Identities = 161/416 (38%), Positives = 230/416 (55%), Gaps = 22/416 (5%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           L+ L+ GY    RP IG  P  +   + V SI  ++  NMEYT+ +F  Q+W D RL +N
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
            T + L L+S  V K+W+PDTF  N+K A  H +T  N+++R+  DG +LY++R+T    
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C + L  +PMDE  C L+  SYGY  E+IVY W  S   +      +L QF+    R TT
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
           E++   ++G +  +S++F L R  G + IQ+Y+P  L+V +SWVSFWI++ AVPAR SLG
Sbjct: 250 EVVK-TTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLG 308

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKA 343
           ITTVLTMTTL   AR SLP+ S + A+D++  +C++FVF+ALVEY   H+    RK  K 
Sbjct: 309 ITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKD 368

Query: 344 KVKVSR-PRAEM--------DVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSV 394
           K K  + P   M        D+R       ++ A   QE         + G    S+   
Sbjct: 369 KDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFC- 427

Query: 395 GVETGETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
                E  + GA R    G I  R+  +D+     YAR  FP AF   N++YW +Y
Sbjct: 428 ---CFEDCRTGAWR---HGRIHIRIAKMDS-----YARIFFPTAFCLFNLVYWVSY 472


>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 449

 Score =  285 bits (728), Expect = 8e-77
 Identities = 159/412 (38%), Positives = 228/412 (55%), Gaps = 15/412 (3%)

Query: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99
           +L  L G  +GY    RP   GPPVNV+  + + S   I+E  M+Y + +FL Q W D R
Sbjct: 41  FLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPR 100

Query: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158
           L+YN + +++L LD   +D +W PD F  N K A FH++T +NKL+R+  +G +LYSIRI
Sbjct: 101 LAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRI 160

Query: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218
           T T+AC MDL  +PMD Q C++ LES+GY+  D+++ W E Q  +   D L L QF +  
Sbjct: 161 TLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVADGLTLPQFILKE 219

Query: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
            +         + G+F  +   FHL R  G Y+IQ Y+PS+L+V +SW+SFWI+  A PA
Sbjct: 220 EKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPA 279

Query: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYR 338
           RV LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVF+AL+EYA  +F +   
Sbjct: 280 RVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQH 339

Query: 339 KKQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVET 398
           K+     +  R   E +       F+ SA G+      ++    V           G   
Sbjct: 340 KELLRFRRKRRHHKEDEAGEG--RFNFSAYGMGPACLQAKDGISVK----------GANN 387

Query: 399 GETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
             T     A S     +R +L    A  ID  +R  FP AF   N+ YW  Y
Sbjct: 388 SNTTNPPPAPSKSPEEMR-KLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 438


>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
          Length = 449

 Score =  284 bits (726), Expect = 1e-76
 Identities = 154/412 (37%), Positives = 229/412 (55%), Gaps = 22/412 (5%)

Query: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99
           +L  L G  +GY    RP   GPPVNV   + + S   I+E  M+Y + +FL Q W D R
Sbjct: 46  FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPR 105

Query: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158
           L+Y+ + +++L LD   +D +W PD F  N K A FH+VT +NKL+R+  +G +LYSIR+
Sbjct: 106 LAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRL 165

Query: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218
           T T++C MDL  +PMD Q C++ LES+GY+  D+++ W + +  +   + L L QF +  
Sbjct: 166 TLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQD-EAPVQVAEGLTLPQFLLKE 224

Query: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
            +         + G+F  + + FHL R  G Y+IQ Y+PS+L+V +SWVSFWI+  A PA
Sbjct: 225 EKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPA 284

Query: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYR 338
           RV+LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVF+AL+EYA  +F     
Sbjct: 285 RVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNF---VS 341

Query: 339 KKQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVET 398
           ++ K  ++  R R   D       FS +A G+     +  +    P       + +    
Sbjct: 342 RQHKELLRFRRKRKNKDDEVRESRFSFTAYGMGP--CLQAKDGMTPKGPNHPVQVMPKSP 399

Query: 399 GETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
            E +K    R               A  ID  +RA FP AF   N+ YW  Y
Sbjct: 400 DEMRKVFIDR---------------AKKIDTISRACFPLAFLIFNIFYWVIY 436


>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 457

 Score =  283 bits (723), Expect = 3e-76
 Identities = 158/412 (38%), Positives = 227/412 (55%), Gaps = 7/412 (1%)

Query: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99
           +L  L G  +GY    RP   GPPVNV+  + + S   I+E  M+Y + +FL Q W D R
Sbjct: 41  FLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPR 100

Query: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158
           L+YN + +++L LD   +D +W PD F  N K A FH++T +NKL+R+  +G +LYSIRI
Sbjct: 101 LAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRI 160

Query: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218
           T T+AC MDL  +PMD Q C++ LES+GY+  D+++ W E Q  +   D L L QF +  
Sbjct: 161 TLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVADGLTLPQFILKE 219

Query: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
            +         + G+F  +   FHL R  G Y+IQ Y+PS+L+V +SW+SFWI+  A PA
Sbjct: 220 EKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPA 279

Query: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYR 338
           RV LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVF+AL+EYA  +F    +
Sbjct: 280 RVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNF-VSRQ 338

Query: 339 KKQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVET 398
            K+  + +  R   +  + N   LF    AG  +    +                 G   
Sbjct: 339 HKELLRFRRKRRHHKSPMLN---LFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANN 395

Query: 399 GETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
             T     A S     +R +L    A  ID  +R  FP AF   N+ YW  Y
Sbjct: 396 SNTTNPPPAPSKSPEEMR-KLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 446


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score =  278 bits (712), Expect = 6e-75
 Identities = 132/308 (42%), Positives = 201/308 (65%), Gaps = 1/308 (0%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           LD +++ Y    RP  GG PV V +++ V SI+ ISE NM+YT+T+F HQ+W+DSRL+Y 
Sbjct: 63  LDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYY 122

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
            T   L LD R  +KLW+PD + +N+K A+ HDVTVEN++ +L PDG + Y IR+T+T A
Sbjct: 123 ETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAA 182

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C +DL K+PMD+Q C L +ESYGY+ EDI+ +W ++   IH  ++L + QFT      T+
Sbjct: 183 CSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITS 242

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
           + + F + G + RL L F ++R    Y++Q Y P+VL    SW+SFW++  +  ARV++G
Sbjct: 243 KEVYFYT-GSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIG 301

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKA 343
           +T++L +TT+    R  LP  S IKA+D+Y  +C  FVF +L+EY + ++    R  ++ 
Sbjct: 302 LTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQ 361

Query: 344 KVKVSRPR 351
             +  RPR
Sbjct: 362 PRRHRRPR 369



 Score = 28.9 bits (63), Expect = 10.0
 Identities = 9/21 (42%), Positives = 15/21 (71%)

Query: 427 IDIYARAVFPAAFAAVNVIYW 447
           +D ++R +FP AF   N++YW
Sbjct: 607 VDKWSRFLFPLAFGLFNIVYW 627


>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
          Length = 417

 Score =  271 bits (693), Expect = 9e-73
 Identities = 136/319 (42%), Positives = 199/319 (62%), Gaps = 2/319 (0%)

Query: 40  WLPNLDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSR 99
           +L  L G  +GY    RP   GPPVNV   + + S   I++  M+Y + VFL Q W D R
Sbjct: 47  FLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPR 106

Query: 100 LSYN-HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRI 158
           LSY  + +++L LD   +D +W PD F  N K A FH+VT +NKL+R+  +G +LYSIR+
Sbjct: 107 LSYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRL 166

Query: 159 TSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS 218
           T  ++C MDL  +PMD Q C + LES+GY+ +D+V+ W E    +   + L L QF +  
Sbjct: 167 TLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRD 226

Query: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
            +         + G+F  + + FHL R  G Y+IQ Y+PS+L+V +SWVSFWI+  A PA
Sbjct: 227 EKDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPA 286

Query: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF-NADY 337
           RV LGITTVLTMTT    +R+SLP+ S +KA+D++  +C +FVFAAL+EYA  +F +  +
Sbjct: 287 RVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQH 346

Query: 338 RKKQKAKVKVSRPRAEMDV 356
           ++  + + +  R R E D+
Sbjct: 347 KEFIRLRRRQRRQRLEEDI 365


>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
           [Homo sapiens]
          Length = 465

 Score =  266 bits (680), Expect = 3e-71
 Identities = 153/410 (37%), Positives = 227/410 (55%), Gaps = 18/410 (4%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           L+ L+ GY    RP IG  P  +   + V SI  +   NMEYT+ +   Q+W DSRL +N
Sbjct: 68  LNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFN 127

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
            T + L L+S  V K+W+PDTF  N++ +  H +T  N+L+R+  DG +LY++R+T    
Sbjct: 128 STMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAE 187

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C + L  +PMDE  C L+  SYGY   +I Y W +    +      +L QF     R +T
Sbjct: 188 CYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNST 247

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
           E+ +  S G +  +++ F L R  G + IQ+Y+P +L V +SWVSFWI++ AVPAR SLG
Sbjct: 248 EITHTIS-GDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLG 306

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAH-FNADYRKKQK 342
           ITTVLTMTTL   AR SLP+ S + A+D++  +C++FVFAAL+EY   H F ++ + K  
Sbjct: 307 ITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTA 366

Query: 343 AKVKVSRPRAEM--DVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGE 400
            K +  + +A M   +     L  ++   V QE       + + G    S+        E
Sbjct: 367 TKDRKLKNKASMTPGLHPGSTLIPMNNISVPQE--DDYGYQCLEGKDCASFFC----CFE 420

Query: 401 TKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
             + G+ R   +G I  R+  ID+     Y+R  FP AFA  N++YW  Y
Sbjct: 421 DCRTGSWR---EGRIHIRIAKIDS-----YSRIFFPTAFALFNLVYWVGY 462


>gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3
           precursor [Homo sapiens]
          Length = 515

 Score =  264 bits (674), Expect = 1e-70
 Identities = 161/456 (35%), Positives = 229/456 (50%), Gaps = 62/456 (13%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           L+ L+ GY    RP IG  P  +   + V SI  ++  NMEYT+ +F  Q+W D RL +N
Sbjct: 70  LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
            T + L L+S  V K+W+PDTF  N+K A  H +T  N+++R+  DG +LY++R+T    
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189

Query: 164 CDMDLAKYPMDEQECMLDLESY-------------------------------------- 185
           C + L  +PMDE  C L+  S+                                      
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249

Query: 186 --GYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHL 243
             GY  E+IVY W  S   +      +L QF+    R TTE++   S G +  +S++F L
Sbjct: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTS-GDYVVMSVYFDL 308

Query: 244 RRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPR 303
            R  G + IQ+Y+P  L+V +SWVSFWI++ AVPAR SLGITTVLTMTTL   AR SLP+
Sbjct: 309 SRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPK 368

Query: 304 ASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSR-PRAEM-------- 354
            S + A+D++  +C++FVF+ALVEY   H+    RK  K K K  + P   M        
Sbjct: 369 VSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTI 428

Query: 355 DVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGG 414
           D+R       ++ A   QE         + G    S+        E  + GA R    G 
Sbjct: 429 DIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFC----CFEDCRTGAWR---HGR 481

Query: 415 IRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
           I  R+  +D+     YAR  FP AF   N++YW +Y
Sbjct: 482 IHIRIAKMDS-----YARIFFPTAFCLFNLVYWVSY 512


>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
           [Homo sapiens]
          Length = 467

 Score =  263 bits (671), Expect = 3e-70
 Identities = 154/427 (36%), Positives = 228/427 (53%), Gaps = 33/427 (7%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           L+ L+  Y +  RP IG  P  + + + V SI  +S  NMEY + +F  Q+W DSRL +N
Sbjct: 51  LNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFN 110

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
            T + L L+S  V  +W+PDT   N+K+A  H +T  N+L+R+  DG ILY++R+T    
Sbjct: 111 STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
           C + L  +PMDE  C L   SYGY  E+++Y W ++          +L QF     R TT
Sbjct: 171 CQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTT 230

Query: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
           E++   SAG +  ++++F L R  G + IQ+Y+P +L V +SWVSFWI + A PAR +LG
Sbjct: 231 EIVT-TSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALG 289

Query: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKA 343
           ITTVLTMTTL   AR SLPR S + A+D++  +C++FVFAAL+EYA  ++ +  RK    
Sbjct: 290 ITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTT 349

Query: 344 KVKVSRPRAE-------------------MDVR-NAIVLFSLSAAGVTQELAISRRQRRV 383
           K   S    +                   +D+R     + +L+ +   QE   +     +
Sbjct: 350 KKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECL 409

Query: 384 PGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVN 443
            G    S+     E     K G+ R G       R+  ID   +D Y+R  FP +F   N
Sbjct: 410 DGKDCQSFFCCYEEC----KSGSWRKG-------RIH-IDILELDSYSRVFFPTSFLLFN 457

Query: 444 VIYWAAY 450
           ++YW  Y
Sbjct: 458 LVYWVGY 464


>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
           precursor [Homo sapiens]
          Length = 462

 Score =  257 bits (656), Expect = 2e-68
 Identities = 142/412 (34%), Positives = 228/412 (55%), Gaps = 21/412 (5%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           LDGL+ GY    RPG+G     V   + V S   +S+  MEYT+ VF  QSW+D RL + 
Sbjct: 53  LDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFK 112

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
              + L L++    K+W PDTF  N K +  H++T  NKL+RL+ DG +LY++R+T +  
Sbjct: 113 GPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAE 172

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWS--ESQEHIHGLDKLQLAQFTITSYRF 221
           C M L  +PMD   C L   SY Y + ++VY W+   ++  +   D  +L Q+ +     
Sbjct: 173 CPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTV 232

Query: 222 TTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVS 281
            TE ++  S G++  ++ HFHL+R  G ++IQ+Y+P ++ V +S VSFW+++ +VPAR  
Sbjct: 233 GTENIS-TSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTV 291

Query: 282 LGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQ 341
            G+TTVLTMTTL +SAR+SLP+ +   A+D +  +CY FVF+AL+E+A  ++   + K+ 
Sbjct: 292 FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY---FTKRG 348

Query: 342 KA-KVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRR--QRRVPGNLMGSYRSVGVET 398
            A   K +   A++  +  ++L   + A  T +++      + + P     +  SV V+ 
Sbjct: 349 WAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNT-TSVSVKP 407

Query: 399 GETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
            E K   + ++                 ID  +R VFP  F   N++YWA Y
Sbjct: 408 SEEKTSESKKTYN-----------SISKIDKMSRIVFPVLFGTFNLVYWATY 448


>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
           [Homo sapiens]
          Length = 453

 Score =  249 bits (637), Expect = 3e-66
 Identities = 144/414 (34%), Positives = 216/414 (52%), Gaps = 16/414 (3%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           LD L+ GY    RPG GG    V   + V S   +S+  MEYTM VF  Q+W D RL + 
Sbjct: 36  LDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFG 95

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
              E L L++  V K+W PDTF  N K +  H++T  NKL R+  +G ILY++R+T    
Sbjct: 96  GPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINAD 155

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGL--DKLQLAQFTITSYRF 221
           C M L  +PMD   C L   SY Y   +I+Y W +   +   +  +   L Q+ +     
Sbjct: 156 CPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTV 215

Query: 222 TTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVS 281
           ++E +   + G++  ++++FHL+R  G ++IQ Y P ++ V +S VSFWI++ +VPAR  
Sbjct: 216 SSETIK-SNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTV 274

Query: 282 LGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYR-KK 340
            GITTVLTMTTL +SAR SLP+ S   A+D +  +C+ FVF+AL+E+A  ++  + + +K
Sbjct: 275 FGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQK 334

Query: 341 QKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGE 400
            K K + + P          V  S +   +  E+ +    +      + S     V + E
Sbjct: 335 AKRKAQFAAP--------PTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSE 386

Query: 401 TKK--EGAARSGGQGGIRARLRPIDADT--IDIYARAVFPAAFAAVNVIYWAAY 450
             K    A            L P    T  ID Y+R +FP AFA  N++YW  Y
Sbjct: 387 ANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVY 440


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score =  249 bits (635), Expect = 5e-66
 Identities = 141/428 (32%), Positives = 218/428 (50%), Gaps = 54/428 (12%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           LD L+ GY    RPG+G     V   + V S   +S+ +MEYT+ VF  Q W+D RL + 
Sbjct: 46  LDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFK 105

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
                L L++    K+W PDTF  N K +  H++T+ NKL+R+Q DG +LY++R+T    
Sbjct: 106 GPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAE 165

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYW--SESQEHIHGLDKLQLAQFTITSYRF 221
           C M L  +PMD   C L   SY Y++ ++ Y W  + S       D  +L Q+ +     
Sbjct: 166 CPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSI 225

Query: 222 TTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVS 281
             E +   S G++  ++ HFHL+R  G ++IQ+Y+P ++ V +S VSFW+++ +VPAR  
Sbjct: 226 GKETIK-SSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTV 284

Query: 282 LGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF-------- 333
            G+TTVLTMTTL +SAR+SLP+ +   A+D +  +CY FVF+AL+E+A  ++        
Sbjct: 285 FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAW 344

Query: 334 ----NADYRKKQKAKVKVSRPRAEMDVRNAI-------VLFSLSAAGVTQELAISRRQRR 382
                 + +KK+KA V +      + V N         VL ++S +  T E   +++   
Sbjct: 345 DGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPE--PNKKPEN 402

Query: 383 VPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAV 442
            P     ++ SV                                ID  +R VFP  F   
Sbjct: 403 KPAEAKKTFNSV------------------------------SKIDRMSRIVFPVLFGTF 432

Query: 443 NVIYWAAY 450
           N++YWA Y
Sbjct: 433 NLVYWATY 440


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score =  249 bits (635), Expect = 5e-66
 Identities = 141/428 (32%), Positives = 218/428 (50%), Gaps = 54/428 (12%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           LD L+ GY    RPG+G     V   + V S   +S+ +MEYT+ VF  Q W+D RL + 
Sbjct: 46  LDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFK 105

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
                L L++    K+W PDTF  N K +  H++T+ NKL+R+Q DG +LY++R+T    
Sbjct: 106 GPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAE 165

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYW--SESQEHIHGLDKLQLAQFTITSYRF 221
           C M L  +PMD   C L   SY Y++ ++ Y W  + S       D  +L Q+ +     
Sbjct: 166 CPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSI 225

Query: 222 TTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVS 281
             E +   S G++  ++ HFHL+R  G ++IQ+Y+P ++ V +S VSFW+++ +VPAR  
Sbjct: 226 GKETIK-SSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTV 284

Query: 282 LGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF-------- 333
            G+TTVLTMTTL +SAR+SLP+ +   A+D +  +CY FVF+AL+E+A  ++        
Sbjct: 285 FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAW 344

Query: 334 ----NADYRKKQKAKVKVSRPRAEMDVRNAI-------VLFSLSAAGVTQELAISRRQRR 382
                 + +KK+KA V +      + V N         VL ++S +  T E   +++   
Sbjct: 345 DGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPE--PNKKPEN 402

Query: 383 VPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAV 442
            P     ++ SV                                ID  +R VFP  F   
Sbjct: 403 KPAEAKKTFNSV------------------------------SKIDRMSRIVFPVLFGTF 432

Query: 443 NVIYWAAY 450
           N++YWA Y
Sbjct: 433 NLVYWATY 440


>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
           [Homo sapiens]
          Length = 554

 Score =  249 bits (635), Expect = 5e-66
 Identities = 127/313 (40%), Positives = 189/313 (60%), Gaps = 4/313 (1%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           LD L+ GY    RPG GGP   V   + V S   +S+  MEYTM VF  Q+W D RL Y+
Sbjct: 52  LDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
              E L L++  V K+W PDTF  N K +  H++T  NKL R+  +G ILY++R+T +  
Sbjct: 112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAE 171

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDK--LQLAQFTITSYRF 221
           C M L  +PMD   C L   SY Y   +++Y W++  E    + K    L Q+ +     
Sbjct: 172 CPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTV 231

Query: 222 TTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVS 281
           ++E +     G++  ++++FHLRR  G ++IQ+Y+P ++ V +S VSFWI++ +VPAR  
Sbjct: 232 SSETIK-SITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTV 290

Query: 282 LGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQ 341
            GITTVLTMTTL +SAR SLP+ S   A+D +  +C+ FVF+AL+E+A  ++  +  + +
Sbjct: 291 FGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNI-QME 349

Query: 342 KAKVKVSRPRAEM 354
           KAK K S+P  E+
Sbjct: 350 KAKRKTSKPPQEV 362



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 13/24 (54%), Positives = 16/24 (66%)

Query: 427 IDIYARAVFPAAFAAVNVIYWAAY 450
           ID YAR +FP  F A N++YW  Y
Sbjct: 518 IDKYARILFPVTFGAFNMVYWVVY 541


>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
           precursor [Homo sapiens]
          Length = 456

 Score =  245 bits (626), Expect = 5e-65
 Identities = 140/411 (34%), Positives = 218/411 (53%), Gaps = 18/411 (4%)

Query: 44  LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
           LD L+ GY    RPG+G     V   + V S   +S+ +MEYT+ VF  QSW+D RL + 
Sbjct: 46  LDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFK 105

Query: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
                L L++    K+W PDTF  N K +  H++T+ NKL+R+  DG +LY++R+T    
Sbjct: 106 GPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAE 165

Query: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSE--SQEHIHGLDKLQLAQFTITSYRF 221
           C M L  +PMD   C L   SY Y+  ++VY W+   ++  +   D  +L Q+ +     
Sbjct: 166 CPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTV 225

Query: 222 TTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVS 281
            + ++   S G++  ++ HFHL+R  G ++IQ+Y+P ++ V +S VSFW+++ +VPAR  
Sbjct: 226 DSGIVQ-SSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTV 284

Query: 282 LGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF--NADYRK 339
            G+TTVLTMTTL +SAR+SLP+ +   A+D +  +CY FVF+AL+E+A  ++     Y  
Sbjct: 285 FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAW 344

Query: 340 KQKAKVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETG 399
             K+ V     + +  +      ++ +A   T  LA     R  PG L    +S  +E  
Sbjct: 345 DGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLA-----RGDPG-LATIAKSATIEPK 398

Query: 400 ETKKEGAARSGGQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
           E K E             +        ID  +R  FP  F   N++YWA Y
Sbjct: 399 EVKPETKPP-------EPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATY 442


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.135    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,302,487
Number of Sequences: 37866
Number of extensions: 612375
Number of successful extensions: 1426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1257
Number of HSP's gapped (non-prelim): 88
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.