Search of human proteins with 34577122

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
         (969 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]         1946   0.0  
gi|117320531 nuclear factor of kappa light polypeptide gene enha...   658   0.0  
gi|117320540 nuclear factor of kappa light polypeptide gene enha...   657   0.0  
gi|117320527 nuclear factor of kappa light polypeptide gene enha...   657   0.0  
gi|4506473 v-rel reticuloendotheliosis viral oncogene homolog [H...   251   2e-66
gi|223468681 v-rel reticuloendotheliosis viral oncogene homolog ...   234   2e-61
gi|223468676 v-rel reticuloendotheliosis viral oncogene homolog ...   233   5e-61
gi|35493878 reticuloendotheliosis viral oncogene homolog B [Homo...   224   3e-58
gi|10092619 nuclear factor of kappa light polypeptide gene enhan...   139   2e-32
gi|71274109 nuclear factor of kappa light polypeptide gene enhan...   136   8e-32
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]                     129   1e-29
gi|21361135 nuclear factor of kappa light polypeptide gene enhan...   100   5e-21
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   100   7e-21
gi|53832024 nuclear factor of kappa light polypeptide gene enhan...    94   5e-19
gi|13899229 nuclear factor of kappa light polypeptide gene enhan...    94   5e-19
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         94   5e-19
gi|30348954 mindbomb homolog 1 [Homo sapiens]                          92   2e-18
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   91   4e-18
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        90   9e-18
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         90   9e-18
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         90   9e-18
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    90   1e-17
gi|41281709 nuclear factor of kappa light polypeptide gene enhan...    89   2e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        88   3e-17
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         88   3e-17
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         88   3e-17
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         88   3e-17
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         88   3e-17
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...    86   2e-16
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                    86   2e-16

>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
          Length = 969

 Score = 1946 bits (5040), Expect = 0.0
 Identities = 969/969 (100%), Positives = 969/969 (100%)

Query: 1   MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRY 60
           MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRY
Sbjct: 1   MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRY 60

Query: 61  VCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCE 120
           VCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCE
Sbjct: 61  VCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCE 120

Query: 121 DGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQ 180
           DGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQ
Sbjct: 121 DGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQ 180

Query: 181 AEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAI 240
           AEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAI
Sbjct: 181 AEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAI 240

Query: 241 YDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGD 300
           YDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGD
Sbjct: 241 YDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGD 300

Query: 301 FSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEV 360
           FSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEV
Sbjct: 301 FSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEV 360

Query: 361 QRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITF 420
           QRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITF
Sbjct: 361 QRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITF 420

Query: 421 HPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNG 480
           HPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNG
Sbjct: 421 HPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNG 480

Query: 481 EVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQ 540
           EVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQ
Sbjct: 481 EVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQ 540

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE
Sbjct: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAM 660
           DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAM
Sbjct: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAM 660

Query: 661 MSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG 720
           MSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG
Sbjct: 661 MSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG 720

Query: 721 TTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMA 780
           TTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMA
Sbjct: 721 TTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMA 780

Query: 781 TSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKL 840
           TSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKL
Sbjct: 781 TSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKL 840

Query: 841 GLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTS 900
           GLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTS
Sbjct: 841 GLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTS 900

Query: 901 QAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYG 960
           QAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYG
Sbjct: 901 QAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYG 960

Query: 961 QEGPLEGKI 969
           QEGPLEGKI
Sbjct: 961 QEGPLEGKI 969


>gi|117320531 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform a [Homo sapiens]
          Length = 900

 Score =  658 bits (1698), Expect = 0.0
 Identities = 396/894 (44%), Positives = 523/894 (58%), Gaps = 72/894 (8%)

Query: 27  NPEVFQPQMALP-TADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQV 85
           N  + +P+   P TADGPYL I+EQPKQRGFRFRY CEGPSHGGLPGASSEK +K+YP V
Sbjct: 21  NSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTV 80

Query: 86  KICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED-GICTVTAGPKDMVVGFANLGILH 144
           KICNY GPAK+ V LVT+      HAHSLVGK C + GIC V+ GPKDM   F NLG+LH
Sbjct: 81  KICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLH 140

Query: 145 VTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQ 204
           VTKK +  T+  ++    +R    GL                    + E+  + Q A + 
Sbjct: 141 VTKKNMMGTMIQKLQRQRLRSRPQGLT-------------------EAEQRELEQEAKEL 181

Query: 205 TKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVT 264
            K MDLS+VRL F+AFL  S GSF+  L+PV+S  I+DSK+P ASNLKI RMD+TAG V 
Sbjct: 182 KKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVR 241

Query: 265 GGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINI 324
           GG+E+YLLCDKVQKDDI++RFYE++ENG  W+ FGDFSPTDVH+Q+AIVF+TP Y  + I
Sbjct: 242 GGDEVYLLCDKVQKDDIEVRFYEDDENG--WQAFGDFSPTDVHKQYAIVFRTPPYHKMKI 299

Query: 325 TKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAG 384
            +P +VF+QL+RK   + S+ K F YYP ++DKEEVQRKR+K +P FS  FGGGS  G G
Sbjct: 300 ERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGG 359

Query: 385 GGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDP 444
            GG  G  GG GG GS G    FP         + + P   +S AG             P
Sbjct: 360 SGGAAGGYGGAGGGGSLG---FFP-------SSLAYSP--YQSGAG-------------P 394

Query: 445 EGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLE 504
            GC            G  +  T   ++  E        + T     +      +   +  
Sbjct: 395 MGCYPGGGG------GAQMAATVPSRDSGEEAAEPSAPSRTPQCEPQAPEMLQRAREYNA 448

Query: 505 KAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLL 564
           +   LA+R A AL DY VT D + LLA QRHL   QDENGD+ LHLAIIH  + ++  ++
Sbjct: 449 RLFGLAQRSARALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIV 508

Query: 565 EVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLA- 623
            V        ++N+ N L+QTPLHLAVIT Q  VV  LLR GAD +LLDR G+S +HLA 
Sbjct: 509 YVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLAL 568

Query: 624 -AKEGHDKVLSILLKHKKAAL--LLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNA 680
            A  G  ++L  LL+    A+  LL  P+ +GL  +HLA+ + S  CL LLV +GA+V A
Sbjct: 569 RAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEA 628

Query: 681 QEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLK 740
            E++ GRTALHLA E + + L   L+ +  A+V++ T+ G TPLH+AAG G   L  LL 
Sbjct: 629 TERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLL 688

Query: 741 AAGADPLVENFEPLYDL------DDSWENAGEDEGV---VPGTTPLDMATSWQVFDILNG 791
            AGAD   EN EPL  L      D   ++ G ++       G TPLD+  S +V  +L  
Sbjct: 689 KAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLN 748

Query: 792 ---KPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNA 848
                 EP  T       G    L +     L +LL+ P+   +WA LA++LGL  L + 
Sbjct: 749 AAQNTMEPPLTPPSPAGPG--LSLGDTALQNLEQLLDGPEAQGSWAELAERLGLRSLVDT 806

Query: 849 FRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQA 902
           +R + +PS +L+ +YE++GG +  L+EAL  MG  E + +++   +  K  S A
Sbjct: 807 YRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGLEEGVRLLRGPETRDKLPSTA 860


>gi|117320540 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  657 bits (1695), Expect = 0.0
 Identities = 395/892 (44%), Positives = 522/892 (58%), Gaps = 72/892 (8%)

Query: 27  NPEVFQPQMALP-TADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQV 85
           N  + +P+   P TADGPYL I+EQPKQRGFRFRY CEGPSHGGLPGASSEK +K+YP V
Sbjct: 21  NSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTV 80

Query: 86  KICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED-GICTVTAGPKDMVVGFANLGILH 144
           KICNY GPAK+ V LVT+      HAHSLVGK C + GIC V+ GPKDM   F NLG+LH
Sbjct: 81  KICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLH 140

Query: 145 VTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQ 204
           VTKK +  T+  ++    +R    GL                    + E+  + Q A + 
Sbjct: 141 VTKKNMMGTMIQKLQRQRLRSRPQGLT-------------------EAEQRELEQEAKEL 181

Query: 205 TKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVT 264
            K MDLS+VRL F+AFL  S GSF+  L+PV+S  I+DSK+P ASNLKI RMD+TAG V 
Sbjct: 182 KKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVR 241

Query: 265 GGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINI 324
           GG+E+YLLCDKVQKDDI++RFYE++ENG  W+ FGDFSPTDVH+Q+AIVF+TP Y  + I
Sbjct: 242 GGDEVYLLCDKVQKDDIEVRFYEDDENG--WQAFGDFSPTDVHKQYAIVFRTPPYHKMKI 299

Query: 325 TKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAG 384
            +P +VF+QL+RK   + S+ K F YYP ++DKEEVQRKR+K +P FS  FGGGS  G G
Sbjct: 300 ERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGG 359

Query: 385 GGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDP 444
            GG  G  GG GG GS G    FP         + + P   +S AG             P
Sbjct: 360 SGGAAGGYGGAGGGGSLG---FFP-------SSLAYSP--YQSGAG-------------P 394

Query: 445 EGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLE 504
            GC            G  +  T   ++  E        + T     +      +   +  
Sbjct: 395 MGCYPGGGG------GAQMAATVPSRDSGEEAAEPSAPSRTPQCEPQAPEMLQRAREYNA 448

Query: 505 KAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLL 564
           +   LA+R A AL DY VT D + LLA QRHL   QDENGD+ LHLAIIH  + ++  ++
Sbjct: 449 RLFGLAQRSARALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIV 508

Query: 565 EVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLA- 623
            V        ++N+ N L+QTPLHLAVIT Q  VV  LLR GAD +LLDR G+S +HLA 
Sbjct: 509 YVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLAL 568

Query: 624 -AKEGHDKVLSILLKHKKAAL--LLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNA 680
            A  G  ++L  LL+    A+  LL  P+ +GL  +HLA+ + S  CL LLV +GA+V A
Sbjct: 569 RAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEA 628

Query: 681 QEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLK 740
            E++ GRTALHLA E + + L   L+ +  A+V++ T+ G TPLH+AAG G   L  LL 
Sbjct: 629 TERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLL 688

Query: 741 AAGADPLVENFEPLYDL------DDSWENAGEDEGV---VPGTTPLDMATSWQVFDILNG 791
            AGAD   EN EPL  L      D   ++ G ++       G TPLD+  S +V  +L  
Sbjct: 689 KAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLN 748

Query: 792 ---KPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNA 848
                 EP  T       G    L +     L +LL+ P+   +WA LA++LGL  L + 
Sbjct: 749 AAQNTMEPPLTPPSPAGPG--LSLGDTALQNLEQLLDGPEAQGSWAELAERLGLRSLVDT 806

Query: 849 FRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTS 900
           +R + +PS +L+ +YE++GG +  L+EAL  MG  E + +++   +  K  S
Sbjct: 807 YRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGLEEGVRLLRGPETRDKLPS 858


>gi|117320527 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  657 bits (1695), Expect = 0.0
 Identities = 395/892 (44%), Positives = 522/892 (58%), Gaps = 72/892 (8%)

Query: 27  NPEVFQPQMALP-TADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQV 85
           N  + +P+   P TADGPYL I+EQPKQRGFRFRY CEGPSHGGLPGASSEK +K+YP V
Sbjct: 21  NSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTV 80

Query: 86  KICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED-GICTVTAGPKDMVVGFANLGILH 144
           KICNY GPAK+ V LVT+      HAHSLVGK C + GIC V+ GPKDM   F NLG+LH
Sbjct: 81  KICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLH 140

Query: 145 VTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQ 204
           VTKK +  T+  ++    +R    GL                    + E+  + Q A + 
Sbjct: 141 VTKKNMMGTMIQKLQRQRLRSRPQGLT-------------------EAEQRELEQEAKEL 181

Query: 205 TKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVT 264
            K MDLS+VRL F+AFL  S GSF+  L+PV+S  I+DSK+P ASNLKI RMD+TAG V 
Sbjct: 182 KKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVR 241

Query: 265 GGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINI 324
           GG+E+YLLCDKVQKDDI++RFYE++ENG  W+ FGDFSPTDVH+Q+AIVF+TP Y  + I
Sbjct: 242 GGDEVYLLCDKVQKDDIEVRFYEDDENG--WQAFGDFSPTDVHKQYAIVFRTPPYHKMKI 299

Query: 325 TKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAG 384
            +P +VF+QL+RK   + S+ K F YYP ++DKEEVQRKR+K +P FS  FGGGS  G G
Sbjct: 300 ERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGG 359

Query: 385 GGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDP 444
            GG  G  GG GG GS G    FP         + + P   +S AG             P
Sbjct: 360 SGGAAGGYGGAGGGGSLG---FFP-------SSLAYSP--YQSGAG-------------P 394

Query: 445 EGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLE 504
            GC            G  +  T   ++  E        + T     +      +   +  
Sbjct: 395 MGCYPGGGG------GAQMAATVPSRDSGEEAAEPSAPSRTPQCEPQAPEMLQRAREYNA 448

Query: 505 KAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLL 564
           +   LA+R A AL DY VT D + LLA QRHL   QDENGD+ LHLAIIH  + ++  ++
Sbjct: 449 RLFGLAQRSARALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIV 508

Query: 565 EVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLA- 623
            V        ++N+ N L+QTPLHLAVIT Q  VV  LLR GAD +LLDR G+S +HLA 
Sbjct: 509 YVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLAL 568

Query: 624 -AKEGHDKVLSILLKHKKAAL--LLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNA 680
            A  G  ++L  LL+    A+  LL  P+ +GL  +HLA+ + S  CL LLV +GA+V A
Sbjct: 569 RAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEA 628

Query: 681 QEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLK 740
            E++ GRTALHLA E + + L   L+ +  A+V++ T+ G TPLH+AAG G   L  LL 
Sbjct: 629 TERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLL 688

Query: 741 AAGADPLVENFEPLYDL------DDSWENAGEDEGV---VPGTTPLDMATSWQVFDILNG 791
            AGAD   EN EPL  L      D   ++ G ++       G TPLD+  S +V  +L  
Sbjct: 689 KAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLN 748

Query: 792 ---KPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNA 848
                 EP  T       G    L +     L +LL+ P+   +WA LA++LGL  L + 
Sbjct: 749 AAQNTMEPPLTPPSPAGPG--LSLGDTALQNLEQLLDGPEAQGSWAELAERLGLRSLVDT 806

Query: 849 FRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTS 900
           +R + +PS +L+ +YE++GG +  L+EAL  MG  E + +++   +  K  S
Sbjct: 807 YRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGLEEGVRLLRGPETRDKLPS 858


>gi|4506473 v-rel reticuloendotheliosis viral oncogene homolog [Homo
           sapiens]
          Length = 619

 Score =  251 bits (641), Expect = 2e-66
 Identities = 147/327 (44%), Positives = 188/327 (57%), Gaps = 36/327 (11%)

Query: 40  ADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQ 99
           A  PY++I+EQP+QRG RFRY CEG S G +PG  S  N ++YP ++I NY G  KV + 
Sbjct: 5   AYNPYIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQIMNYYGKGKVRIT 64

Query: 100 LVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMT 159
           LVT       H H LVGK C DG      G +   + F NLGI  V KK+V E +  R+ 
Sbjct: 65  LVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKEAIITRI- 123

Query: 160 EACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTA 219
           +A I  +N                  ++QL D E             + DL+VVRL F  
Sbjct: 124 KAGINPFNV----------------PEKQLNDIE-------------DCDLNVVRLCFQV 154

Query: 220 FLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKD 279
           FLPD  G+ T  L PVVS+ IYD++APN + L+I R+++  G V GG+EI+LLCDKVQKD
Sbjct: 155 FLPDEHGNLTTALPPVVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKD 214

Query: 280 DIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSD 339
           DI++RF   +     WE  G FS  DVHRQ AIVFKTP Y    IT+P +V +QLRR SD
Sbjct: 215 DIEVRFVLND-----WEAKGIFSQADVHRQVAIVFKTPPYCKA-ITEPVTVKMQLRRPSD 268

Query: 340 LETSEPKPFLYYPEIKDKEEVQRKRQK 366
            E SE   F Y P+ KD    + K+QK
Sbjct: 269 QEVSESMDFRYLPDEKDTYGNKAKKQK 295


>gi|223468681 v-rel reticuloendotheliosis viral oncogene homolog A
           isoform 2 [Homo sapiens]
          Length = 548

 Score =  234 bits (598), Expect = 2e-61
 Identities = 139/344 (40%), Positives = 181/344 (52%), Gaps = 43/344 (12%)

Query: 28  PEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKI 87
           P +F  + A   A GPY++I+EQPKQRG RFRY CEG S G +PG  S    K++P +KI
Sbjct: 6   PLIFPAEPA--QASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKI 63

Query: 88  CNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTK 147
             Y GP  V + LVT       H H LVGK C DG       P   +  F NLGI  V K
Sbjct: 64  NGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKK 123

Query: 148 KKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKE 207
           + + + +  R+        NP           Q E  GD                     
Sbjct: 124 RDLEQAISQRIQT----NNNP----------FQEEQRGD--------------------- 148

Query: 208 MDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGE 267
            DL+ VRL F   + D +G    RL PV+S  I+D++APN + LKI R++R +G   GG+
Sbjct: 149 YDLNAVRLCFQVTVRDPSGR-PLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGD 207

Query: 268 EIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKP 327
           EI+LLCDKVQK+DI++ F      G  WE  G FS  DVHRQ AIVF+TP Y D ++  P
Sbjct: 208 EIFLLCDKVQKEDIEVYF-----TGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAP 262

Query: 328 ASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNF 371
             V +QLRR SD E SEP  F Y P+  D+  ++ KR++    F
Sbjct: 263 VRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETF 306


>gi|223468676 v-rel reticuloendotheliosis viral oncogene homolog A
           isoform 1 [Homo sapiens]
          Length = 551

 Score =  233 bits (595), Expect = 5e-61
 Identities = 136/344 (39%), Positives = 181/344 (52%), Gaps = 40/344 (11%)

Query: 28  PEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKI 87
           P +F  + A   A GPY++I+EQPKQRG RFRY CEG S G +PG  S    K++P +KI
Sbjct: 6   PLIFPAEPA--QASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKI 63

Query: 88  CNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTK 147
             Y GP  V + LVT       H H LVGK C DG       P   +  F NLGI  V K
Sbjct: 64  NGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKK 123

Query: 148 KKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKE 207
           + + + +  R+        NP                             +    +Q  +
Sbjct: 124 RDLEQAISQRIQT----NNNP----------------------------FQVPIEEQRGD 151

Query: 208 MDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGE 267
            DL+ VRL F   + D +G    RL PV+S  I+D++APN + LKI R++R +G   GG+
Sbjct: 152 YDLNAVRLCFQVTVRDPSGR-PLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGD 210

Query: 268 EIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKP 327
           EI+LLCDKVQK+DI++ F      G  WE  G FS  DVHRQ AIVF+TP Y D ++  P
Sbjct: 211 EIFLLCDKVQKEDIEVYF-----TGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAP 265

Query: 328 ASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNF 371
             V +QLRR SD E SEP  F Y P+  D+  ++ KR++    F
Sbjct: 266 VRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETF 309


>gi|35493878 reticuloendotheliosis viral oncogene homolog B [Homo
           sapiens]
          Length = 579

 Score =  224 bits (571), Expect = 3e-58
 Identities = 137/331 (41%), Positives = 182/331 (54%), Gaps = 41/331 (12%)

Query: 43  PYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKI--CNYVGPAKVIVQL 100
           P+L I EQPKQRG RFRY CEG S G + G SS +  K+ P +++  C  +   +V   L
Sbjct: 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACL 184

Query: 101 VTNGKNIHLHAHSLVGKHCEDGICTVTAGPK-DMVVGFANLGILHVTKKKVFETLEARMT 159
           V       +H HSLVGK C DGIC V   P       F NLGI  V KK++   +E R  
Sbjct: 185 VWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIE-RKI 243

Query: 160 EACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTA 219
           +  I  YN G                               +L+  +E+D++VVR+ F A
Sbjct: 244 QLGIDPYNAG-------------------------------SLKNHQEVDMNVVRICFQA 272

Query: 220 FLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKD 279
              D  G   RR++PV+S+ +YD K+ N S L+I R+++ +G  TGGEE+YLLCDKVQK+
Sbjct: 273 SYRDQQGQM-RRMDPVLSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKE 331

Query: 280 DIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSD 339
           DI + F         WEG  DFS  DVHRQ AIVFKTP Y+D+ I +P +V V L+R +D
Sbjct: 332 DISVVFSRAS-----WEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVNVFLQRLTD 386

Query: 340 LETSEPKPFLYYPEIKDKEEVQRKRQKLMPN 370
              SEP PF Y P   D   V +KR++ MP+
Sbjct: 387 GVCSEPLPFTYLPRDHDSYGVDKKRKRGMPD 417


>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, alpha [Homo sapiens]
          Length = 317

 Score =  139 bits (349), Expect = 2e-32
 Identities = 95/234 (40%), Positives = 127/234 (54%), Gaps = 10/234 (4%)

Query: 542 ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED 601
           E+GDS LHLAIIH    L  +++    G ++   +N +N+L QTPLHLAVIT Q ++ E 
Sbjct: 72  EDGDSFLHLAIIHEEKALTMEVIRQVKGDLA--FLNFQNNLQQTPLHLAVITNQPEIAEA 129

Query: 602 LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL---LDHPNGDGLNAIHL 658
           LL AG D  L D  GN+ LHLA ++G    + +L +      L   L   N +G   +HL
Sbjct: 130 LLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHL 189

Query: 659 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 718
           A +   L  + LLV+ GADVNAQE  +GRTALHLAV+  N  L   LLL+  A V+  TY
Sbjct: 190 ASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVS-LLLKCGADVNRVTY 248

Query: 719 DGTTPLHIAAGRGSTRLAALLKAAGADPL----VENFEPLYDLDDSWENAGEDE 768
            G +P  +  GR STR+   L     + L        E  YD +  +    EDE
Sbjct: 249 QGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDE 302


>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, epsilon [Homo sapiens]
          Length = 500

 Score =  136 bits (343), Expect = 8e-32
 Identities = 99/296 (33%), Positives = 152/296 (51%), Gaps = 32/296 (10%)

Query: 464 ETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVT 523
           E  + D E +++T G+  +T T +     E+         + A +L   H  AL    + 
Sbjct: 199 EKEDADGERADSTYGSSSLTYTLSLLGGPEAE--------DPAPRLPLPHVGALSPQQLE 250

Query: 524 GDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLY 583
                       LT +  E+GD+++HLA+IH    ++   L     L+  ++++++N+LY
Sbjct: 251 A-----------LTYIS-EDGDTLVHLAVIHEAPAVLLCCL----ALLPQEVLDIQNNLY 294

Query: 584 QTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKA-- 641
           QT LHLAV   Q   V  L+  GA  +L DR G++ LH+A +  H      LL+ +    
Sbjct: 295 QTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPG 354

Query: 642 -----ALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEH 696
                +L L   N  GL  +H+A +  + P + LL+  GAD++ QE  SG+TALHLAVE 
Sbjct: 355 RGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVET 414

Query: 697 DNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFE 752
               L    LL+  A VD+   +G TPLH+AAGRG   +++ L  AGAD L+ N E
Sbjct: 415 QERGLVQ-FLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVE 469


>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
          Length = 454

 Score =  129 bits (324), Expect = 1e-29
 Identities = 94/261 (36%), Positives = 137/261 (52%), Gaps = 24/261 (9%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           DE+GD+ LH+A++  +   V  L+ +         +++ N+L QTPLHLAVIT    VV 
Sbjct: 132 DEDGDTPLHIAVVQGNLPAVHRLVNLFQQ--GGRELDIYNNLRQTPLHLAVITTLPSVVR 189

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL-LDHPNGDGLNAIHLA 659
            L+ AGA    LDR G +  HLA +      L  LL       L L+  N DGL A+H+A
Sbjct: 190 LLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVA 249

Query: 660 MMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYD 719
           + +     + LL+  GAD++A + KSGR+ L  AVE++++S+   LLL+  A+V++  Y 
Sbjct: 250 VNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQ-LLLQHGANVNAQMYS 308

Query: 720 GTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDM 779
           G++ LH A+GRG   L   L  +GAD  ++N                        TPL +
Sbjct: 309 GSSALHSASGRGLLPLVRTLVRSGADSSLKNCH--------------------NDTPLMV 348

Query: 780 ATSWQVFDILNGKPYEPEFTS 800
           A S +V DIL GK   P  TS
Sbjct: 349 ARSRRVIDILRGKATRPASTS 369


>gi|21361135 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, beta isoform a [Homo sapiens]
          Length = 356

 Score =  100 bits (250), Expect = 5e-21
 Identities = 85/272 (31%), Positives = 121/272 (44%), Gaps = 48/272 (17%)

Query: 542 ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED 601
           E+GD+ LHLA+IH H   +  LL  ++G    + ++++NDL QT LHLA I  +   VE 
Sbjct: 56  EDGDTALHLAVIHQHEPFLDFLLGFSAGT---EYMDLQNDLGQTALHLAAILGETSTVEK 112

Query: 602 LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLK------------------------ 637
           L  AGA L + +R G++ LHLA + G       LL+                        
Sbjct: 113 LYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDT 172

Query: 638 -HKKAALL-------------------LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGAD 677
            H   AL                    L+  N +G   +H+A++   +  + LL  AGAD
Sbjct: 173 NHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGAD 232

Query: 678 VNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAA 737
           ++  E   GR+ LHLAVE     +   LLL   A+  +  Y G TPL  A  R +  LA 
Sbjct: 233 LDKPEPTCGRSPLHLAVEAQAADVLE-LLLRAGANPAARMYGGRTPLGSAMLRPNPILAR 291

Query: 738 LLKAAGADPLVENFEPLYDLDDSWENAGEDEG 769
           LL+A GA       E       S ++   DEG
Sbjct: 292 LLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEG 323



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 5/69 (7%)

Query: 540 QDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVV 599
           ++  G + LH+A+IH   ++VR L +  +     D+        ++PLHLAV  +  DV+
Sbjct: 203 ENYEGHTPLHVAVIHKDVEMVRLLRDAGA-----DLDKPEPTCGRSPLHLAVEAQAADVL 257

Query: 600 EDLLRAGAD 608
           E LLRAGA+
Sbjct: 258 ELLLRAGAN 266


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  100 bits (249), Expect = 7e-21
 Identities = 82/257 (31%), Positives = 123/257 (47%), Gaps = 18/257 (7%)

Query: 516 ALFDYAVTGDVKM---LLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLIS 572
           AL   A+ G V+M   LLA   ++ A  D+     LH A    H       L+V + LI+
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAF-DKKDRRALHWAAYMGH-------LDVVALLIN 169

Query: 573 DDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKV 631
               +  ++    TPLH A    Q +VV+ LL  G ++  ++  GN+ LH+A   G D V
Sbjct: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229

Query: 632 LSILLKHKKAALLLDHPNGDGLNAIHLAMMS-NSLPCLLLLVAAGADVNAQEQKSGRTAL 690
           ++ L+ +      ++ PN +G   +H A  S +   CL LLV  GADVN Q  K G++ L
Sbjct: 230 VNELIDY---GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS-KDGKSPL 285

Query: 691 HLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVEN 750
           H+   H   + +  L+  G   +D    DG TPLH+AA  G   L   L+ +GAD     
Sbjct: 286 HMTAVHGRFTRSQTLIQNG-GEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCG 344

Query: 751 FEPLYDLDDSWENAGED 767
              ++ L  +  NA  D
Sbjct: 345 IHSMFPLHLAALNAHSD 361



 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 66/226 (29%), Positives = 109/226 (48%), Gaps = 20/226 (8%)

Query: 503 LEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRD 562
           LE+A +L ++ A    ++ +  D            +++D+ G + +H A  + H Q +  
Sbjct: 475 LERARELKEKEATLCLEFLLQNDAN---------PSIRDKEGYNSIHYAAAYGHRQCLEL 525

Query: 563 LLEVT-SGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLH 621
           LLE T SG    D     +   ++PLHLA        +E LL++  DL + D  G + L 
Sbjct: 526 LLERTNSGFEESD-----SGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALD 580

Query: 622 LAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQ 681
           LAA +GH + +  L+    +  + D  N      +H ++++    CL LL+    +  A 
Sbjct: 581 LAAFKGHTECVEALINPGASIFVKD--NVTKRTPLHASVINGHTLCLRLLLEIADNPEAV 638

Query: 682 EQK--SGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLH 725
           + K   G+T L LAV + +I  A  LLLE +A+VD+    G T LH
Sbjct: 639 DVKDAKGQTPLMLAVAYGHID-AVSLLLEKEANVDTVDILGCTALH 683



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 67/240 (27%), Positives = 110/240 (45%), Gaps = 16/240 (6%)

Query: 521 AVTGDVKM--LLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINM 578
           A  GD ++  LL +       +D    + LH A+     + V+ L++ ++       +N 
Sbjct: 24  AFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD------VNA 77

Query: 579 RNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH 638
           R+  +QTPLH+A   K     E ++   + +++ DR G + LH AA  GH +++++LL  
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137

Query: 639 KKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 698
                  D  +     A+H A     L  + LL+  GA+V  +++K G T LH A  +  
Sbjct: 138 GANINAFDKKD---RRALHWAAYMGHLDVVALLINHGAEVTCKDKK-GYTPLHAAASNGQ 193

Query: 699 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD---PLVENFEPLY 755
           I++   LL  G   +D     G T LHIA   G   +   L   GA+   P    F PL+
Sbjct: 194 INVVKHLLNLG-VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLH 252



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 59/229 (25%), Positives = 104/229 (45%), Gaps = 37/229 (16%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           + NG + LH A    H  L  +LL V +G      +N+++   ++PLH+  +  +    +
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELL-VNNGAD----VNIQSKDGKSPLHMTAVHGRFTRSQ 298

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL------------------------- 635
            L++ G ++  +D+ GN+ LH+AA+ GH+ +++ L                         
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358

Query: 636 -----LKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTAL 690
                 K   +   +D P+  G   +H A    ++ C+ LL ++GAD + ++ K GRT L
Sbjct: 359 HSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH-KKDKCGRTPL 417

Query: 691 HLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALL 739
           H A  + +      L+  G A+V+ T   G T LH AA     R   +L
Sbjct: 418 HYAAANCHFHCIETLVTTG-ANVNETDDWGRTALHYAAASDMDRNKTIL 465



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 59/216 (27%), Positives = 100/216 (46%), Gaps = 11/216 (5%)

Query: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
           V+MLL  +  +   +D  G + LH A    H+  + +LL++    +S++    +++   T
Sbjct: 694 VQMLLEQEVSILC-KDSRGRTPLHYAAARGHATWLSELLQMA---LSEEDCCFKDNQGYT 749

Query: 586 PLHLAVITKQEDVVEDLLRAGADLSLLDRLGN--SVLHLAAKEGHDKVLSILLKHKKAAL 643
           PLH A     E+ +E LL        +   GN  + LH A    H    S+LL    +++
Sbjct: 750 PLHWACYNGNENCIEVLLEQKCFRKFI---GNPFTPLHCAIINDHGNCASLLLGAIDSSI 806

Query: 644 LLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAG 703
           +    +  G   +  A  ++ + CL LL+   A VNA +  SG+TAL +A E+       
Sbjct: 807 VSCRDD-KGRTPLRAAAFADHVECLQLLLRHSAPVNAVDN-SGKTALMMAAENGQAGAVD 864

Query: 704 CLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALL 739
            L+    A +     D  TPLH+A  +G  + A L+
Sbjct: 865 ILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 44/170 (25%), Positives = 85/170 (50%), Gaps = 5/170 (2%)

Query: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
           +N  +   +TPLH+A      +++E L+ +GA ++  D +  + LH A     ++ + +L
Sbjct: 9   VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68

Query: 636 LKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVE 695
           +KH       D    +    +H+A  + ++ C  +++   + VN  + + GRTALH A  
Sbjct: 69  IKHSADVNARDK---NWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD-RGGRTALHHAAL 124

Query: 696 HDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD 745
           + ++ +   LL +G A++++        LH AA  G   + ALL   GA+
Sbjct: 125 NGHVEMVNLLLAKG-ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAE 173



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 63/231 (27%), Positives = 94/231 (40%), Gaps = 47/231 (20%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           D++G++ LH+A  + H  L+  L    +      I +M       PLHLA +    D   
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM------FPLHLAALNAHSDCCR 364

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLK-----HKKAALLLDHPNGDGLNA 655
            LL +G ++   D+ G + LH AA  G+ + + +L       HKK           G   
Sbjct: 365 KLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKC--------GRTP 416

Query: 656 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHD---NISLAG--------- 703
           +H A  +    C+  LV  GA+VN +    GRTALH A   D   N ++ G         
Sbjct: 417 LHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475

Query: 704 -------------CL--LLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALL 739
                        CL  LL+ DA+      +G   +H AA  G  +   LL
Sbjct: 476 ERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/197 (27%), Positives = 88/197 (44%), Gaps = 10/197 (5%)

Query: 548 LHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGA 607
           LH ++I+ H+  +R LLE+     + + +++++   QTPL LAV     D V  LL   A
Sbjct: 613 LHASVINGHTLCLRLLLEIAD---NPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669

Query: 608 DLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPC 667
           ++  +D LG + LH     GH++ + +LL+ + + L  D     G   +H A        
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD---SRGRTPLHYAAARGHATW 726

Query: 668 L--LLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLH 725
           L  LL +A   +    +   G T LH A  + N +    LL +          +  TPLH
Sbjct: 727 LSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLH 784

Query: 726 IAAGRGSTRLAALLKAA 742
            A        A+LL  A
Sbjct: 785 CAIINDHGNCASLLLGA 801



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 53/193 (27%), Positives = 81/193 (41%), Gaps = 27/193 (13%)

Query: 584 QTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL-------- 635
           +TPLH A        +E L+  GA+++  D  G + LH AA    D+  +IL        
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473

Query: 636 -------LKHKKAALLLDH----------PNGDGLNAIHLAMMSNSLPCL-LLLVAAGAD 677
                  LK K+A L L+            + +G N+IH A       CL LLL    + 
Sbjct: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533

Query: 678 VNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAA 737
               +  + ++ LHLA  ++    A  +LL+    +D     G T L +AA +G T    
Sbjct: 534 FEESDSGATKSPLHLAA-YNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592

Query: 738 LLKAAGADPLVEN 750
            L   GA   V++
Sbjct: 593 ALINPGASIFVKD 605



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 58/235 (24%), Positives = 100/235 (42%), Gaps = 36/235 (15%)

Query: 540 QDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVIT------ 593
           +D+ G + LH A  + H   +  L  VT+G      +N  +D  +T LH A  +      
Sbjct: 409 KDKCGRTPLHYAAANCHFHCIETL--VTTGAN----VNETDDWGRTALHYAAASDMDRNK 462

Query: 594 -------------------KQEDV---VEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKV 631
                              K+++    +E LL+  A+ S+ D+ G + +H AA  GH + 
Sbjct: 463 TILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQC 522

Query: 632 LSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALH 691
           L +LL+   +    +  +G   + +HLA  +     L +L+ +  D++ +++K GRTAL 
Sbjct: 523 LELLLERTNSGFE-ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK-GRTALD 580

Query: 692 LAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           LA    +      L+  G +          TPLH +   G T    LL     +P
Sbjct: 581 LAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 6/138 (4%)

Query: 548 LHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGA 607
           LH AII+ H      LL    G I   I++ R+D  +TPL  A      + ++ LLR  A
Sbjct: 783 LHCAIINDHGNCASLLL----GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838

Query: 608 DLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPC 667
            ++ +D  G + L +AA+ G    + IL+   +A L +   + D    +HLA       C
Sbjct: 839 PVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTV--KDKDLNTPLHLACSKGHEKC 896

Query: 668 LLLLVAAGADVNAQEQKS 685
            LL++    D +   +K+
Sbjct: 897 ALLILDKIQDESLINEKN 914


>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform b [Homo sapiens]
          Length = 618

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 77/273 (28%), Positives = 128/273 (46%), Gaps = 39/273 (14%)

Query: 516 ALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDI 575
           +LF + V  +   L  + +     +D +GD+ LH+A+      L   L    + L    +
Sbjct: 316 SLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNAL---HM 372

Query: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
           ++++    Q+   +AV   Q  +V+DL+  GA ++  D  G + LH+ A++GH +VL  +
Sbjct: 373 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 432

Query: 636 LKHKKAA---LLLDHPNGDGLNAIHLAMMSNS---------------------------L 665
            K    +   + L+  N DGL  +H A+++++                           +
Sbjct: 433 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 492

Query: 666 PCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGD--AHVDSTTYDGTTP 723
             +  L+  GA V A+++KSGRTALHLA E  N+ L    L      + V++  Y+G T 
Sbjct: 493 DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTA 552

Query: 724 LHIAAG--RGSTRLAA--LLKAAGADPLVENFE 752
           LH+AA      T+L A  LL   GADP   N E
Sbjct: 553 LHVAASLQYRLTQLDAVRLLMRKGADPSTRNLE 585



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 7/118 (5%)

Query: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
           +K L+ +   + A   ++G + LHLA    + +L+R  LE+ S L     +N +     T
Sbjct: 495 IKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCL---SFVNAKAYNGNT 551

Query: 586 PLHLAVITK----QEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHK 639
            LH+A   +    Q D V  L+R GAD S  +      +HL       + +  +LK K
Sbjct: 552 ALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGK 609


>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform a [Homo sapiens]
          Length = 718

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 77/273 (28%), Positives = 128/273 (46%), Gaps = 39/273 (14%)

Query: 516 ALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDI 575
           +LF + V  +   L  + +     +D +GD+ LH+A+      L   L    + L    +
Sbjct: 416 SLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNAL---HM 472

Query: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
           ++++    Q+   +AV   Q  +V+DL+  GA ++  D  G + LH+ A++GH +VL  +
Sbjct: 473 LDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAI 532

Query: 636 LKHKKAA---LLLDHPNGDGLNAIHLAMMSNS---------------------------L 665
            K    +   + L+  N DGL  +H A+++++                           +
Sbjct: 533 QKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLV 592

Query: 666 PCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGD--AHVDSTTYDGTTP 723
             +  L+  GA V A+++KSGRTALHLA E  N+ L    L      + V++  Y+G T 
Sbjct: 593 DTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTA 652

Query: 724 LHIAAG--RGSTRLAA--LLKAAGADPLVENFE 752
           LH+AA      T+L A  LL   GADP   N E
Sbjct: 653 LHVAASLQYRLTQLDAVRLLMRKGADPSTRNLE 685



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 33/118 (27%), Positives = 54/118 (45%), Gaps = 7/118 (5%)

Query: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
           +K L+ +   + A   ++G + LHLA    + +L+R  LE+ S L     +N +     T
Sbjct: 595 IKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCL---SFVNAKAYNGNT 651

Query: 586 PLHLAVITK----QEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHK 639
            LH+A   +    Q D V  L+R GAD S  +      +HL       + +  +LK K
Sbjct: 652 ALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGK 709


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 62/162 (38%), Positives = 87/162 (53%), Gaps = 5/162 (3%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A    Q D+   LL  GAD + + R G + +HLAA+EGH  ++S+LL       L
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
               N  GL  +HLA   + +    +LV  GA V+AQ  K G T LH+   + NI +   
Sbjct: 693 ---SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ-TKMGYTPLHVGCHYGNIKIVN- 747

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
            LL+  A V++ T +G TPLH AA +G T +  +L    A P
Sbjct: 748 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 72/227 (31%), Positives = 114/227 (50%), Gaps = 13/227 (5%)

Query: 521 AVTGDVKMLLAVQRHLTAVQDEN--GDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINM 578
           A  G V ++  +  H  +    N  G++ LH+A     +++VR L++  + + +      
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEA----KA 496

Query: 579 RNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH 638
           ++D  QTPLH++    + D+V+ LL+ GA  +     G + LHL+A+EGH+ V + LL H
Sbjct: 497 KDD--QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554

Query: 639 KKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 698
             +   L      G   +H+A     L    LL+   A  +A   KSG T LH+A  +DN
Sbjct: 555 GAS---LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA-AGKSGLTPLHVAAHYDN 610

Query: 699 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD 745
             +A  LLL+  A   +   +G TPLHIAA +    +A  L   GAD
Sbjct: 611 QKVA-LLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 71/204 (34%), Positives = 110/204 (53%), Gaps = 17/204 (8%)

Query: 542 ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED 601
           + G++ LH+A +   +++V+ L  VT+G      +N ++    TPL++A      +VV+ 
Sbjct: 105 KKGNTALHIASLAGQAEVVKVL--VTNGAN----VNAQSQNGFTPLYMAAQENHLEVVKF 158

Query: 602 LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM 661
           LL  GA  SL    G + L +A ++GHD+V+S+LL++       D      L A+H+A  
Sbjct: 159 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN-------DTKGKVRLPALHIAAR 211

Query: 662 SNSLPCLLLLVAAGADVNAQ-EQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG 720
            +      LL+    D NA  E KSG T LH+A  + NI++A  LLL   A VD T  + 
Sbjct: 212 KDDTKAAALLLQ--NDNNADVESKSGFTPLHIAAHYGNINVA-TLLLNRAAAVDFTARND 268

Query: 721 TTPLHIAAGRGSTRLAALLKAAGA 744
            TPLH+A+ RG+  +  LL   GA
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGA 292



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 76/266 (28%), Positives = 124/266 (46%), Gaps = 25/266 (9%)

Query: 501 LFLEKAMQLAKRHANAL--FDYAVTGD----VKMLLAVQRHLTAVQDENGD--SVLHLAI 552
           + L++A  +  +  N L     A  GD    V++LL   +H   V D   D  + LH+A 
Sbjct: 319 MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL---QHNVPVDDVTNDYLTALHVAA 375

Query: 553 IHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLL 612
              H ++ + LL+  +   +  +         TPLH+A    +  V+E LL+ GA +  +
Sbjct: 376 HCGHYKVAKVLLDKKANPNAKALNGF------TPLHIACKKNRIKVMELLLKHGASIQAV 429

Query: 613 DRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLV 672
              G + +H+AA  GH  ++S L+ H  +    +  N  G  A+H+A  S     +  LV
Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQLMHHGASP---NTTNVRGETALHMAARSGQAEVVRYLV 486

Query: 673 AAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGS 732
             GA V A + K  +T LH++       +   LL +G A  ++ T  G TPLH++A  G 
Sbjct: 487 QDGAQVEA-KAKDDQTPLHISARLGKADIVQQLLQQG-ASPNAATTSGYTPLHLSAREGH 544

Query: 733 TRLAALLKAAGADPLV---ENFEPLY 755
             +AA L   GA   +   + F PL+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLH 570



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 47/139 (33%), Positives = 82/139 (58%), Gaps = 5/139 (3%)

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAM 660
           D ++ G D+++ ++ G + LHLA+KEGH +V+S LL+ +     +D     G  A+H+A 
Sbjct: 59  DYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN---VDAATKKGNTALHIAS 115

Query: 661 MSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG 720
           ++     + +LV  GA+VNAQ Q +G T L++A + +++ +    LL+  A     T DG
Sbjct: 116 LAGQAEVVKVLVTNGANVNAQSQ-NGFTPLYMAAQENHLEVVK-FLLDNGASQSLATEDG 173

Query: 721 TTPLHIAAGRGSTRLAALL 739
            TPL +A  +G  ++ +LL
Sbjct: 174 FTPLAVALQQGHDQVVSLL 192



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 64/206 (31%), Positives = 106/206 (51%), Gaps = 11/206 (5%)

Query: 539 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDV 598
           V+ ++G + LH+A  H  +  V  LL   +  +       RND+  TPLH+A      ++
Sbjct: 230 VESKSGFTPLHIAA-HYGNINVATLLLNRAAAVD---FTARNDI--TPLHVASKRGNANM 283

Query: 599 VEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHL 658
           V+ LL  GA +    R G + LH  A+ GH++V+ +LL   +AA +L     +GL+ +H+
Sbjct: 284 VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLL--DRAAPILSKTK-NGLSPLHM 340

Query: 659 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 718
           A   + L C+ LL+     V+        TALH+A    +  +A  +LL+  A+ ++   
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVD-DVTNDYLTALHVAAHCGHYKVAK-VLLDKKANPNAKAL 398

Query: 719 DGTTPLHIAAGRGSTRLAALLKAAGA 744
           +G TPLHIA  +   ++  LL   GA
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGA 424



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 56/205 (27%), Positives = 90/205 (43%), Gaps = 34/205 (16%)

Query: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
           IN+ N      LHLA      +VV +LL+  A++    + GN+ LH+A+  G  +V+ +L
Sbjct: 67  INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126

Query: 636 LKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGAD------------------ 677
           + +      ++  + +G   +++A   N L  +  L+  GA                   
Sbjct: 127 VTN---GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQ 183

Query: 678 ----------VNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIA 727
                      N  + K    ALH+A   D+ + A  LLL+ D + D  +  G TPLHIA
Sbjct: 184 GHDQVVSLLLENDTKGKVRLPALHIAARKDD-TKAAALLLQNDNNADVESKSGFTPLHIA 242

Query: 728 AGRGSTRLAALL--KAAGADPLVEN 750
           A  G+  +A LL  +AA  D    N
Sbjct: 243 AHYGNINVATLLLNRAAAVDFTARN 267



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 65/277 (23%), Positives = 107/277 (38%), Gaps = 50/277 (18%)

Query: 544 GDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLL 603
           G + +HLA    H  +V  LL   +       +N+ N    TPLHLA    + +V E L+
Sbjct: 664 GIASVHLAAQEGHVDMVSLLLGRNAN------VNLSNKSGLTPLHLAAQEDRVNVAEVLV 717

Query: 604 RAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSN 663
             GA +    ++G + LH+    G+ K+++ LL+H                         
Sbjct: 718 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH------------------------- 752

Query: 664 SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTP 723
                       A VNA + K+G T LH A +  +  +   +LL+ +A  +  T +G T 
Sbjct: 753 -----------SAKVNA-KTKNGYTPLHQAAQQGHTHIIN-VLLQNNASPNELTVNGNTA 799

Query: 724 LHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGE-----DEGVVPGTTPLD 778
           L IA   G   +   LK    + +           +  E   E     D+ V     P  
Sbjct: 800 LGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEM 859

Query: 779 MATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAED 815
           ++    + D+  G+      T D  L   D+K+L +D
Sbjct: 860 LSDGEYISDVEEGEDAMTGDT-DKYLGPQDLKELGDD 895


>gi|30348954 mindbomb homolog 1 [Homo sapiens]
          Length = 1006

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 83/291 (28%), Positives = 133/291 (45%), Gaps = 22/291 (7%)

Query: 458 LFGKVIETTEQDQEPSEAT--VGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHAN 515
           L  K+ ET E      E      NG+V        K     V        AMQ A ++ +
Sbjct: 418 LLKKLFETQESGDLNEELVKAAANGDVAKVEDL-LKRPDVDVNGQCAGHTAMQAASQNGH 476

Query: 516 ALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDI 575
                    D+  LL  Q      +D++GD  +H A       ++  L   ++ L     
Sbjct: 477 V--------DILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADL----- 523

Query: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
            N RN   QTPLH+AV      VV+ LL  G   SL D  G++ LH A  +  D +L++L
Sbjct: 524 -NARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVL 582

Query: 636 LKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGAD--VNAQEQKSGRTALHLA 693
           L+   A   +   N +G NA+H A +  +   + +L++      +  +++  G TALHLA
Sbjct: 583 LE---AGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 639

Query: 694 VEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
             ++++ +A  L+ +G+A++D    +  T LH+A  R  T++  LL  AGA
Sbjct: 640 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGA 690



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 67/212 (31%), Positives = 111/212 (52%), Gaps = 12/212 (5%)

Query: 520 YAVTGDVKMLLAVQRHLTA---VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDII 576
           +A  GD   ++ V    +A    +++   + LH+A+   H Q+V+ LL+           
Sbjct: 503 HAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHP------ 556

Query: 577 NMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILL 636
           ++++    TPLH A+  K++D++  LL AGAD+++ +  G + LH AA  G+   + +LL
Sbjct: 557 SLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLL 616

Query: 637 KHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG-ADVNAQEQKSGRTALHLAVE 695
                  ++D    DG  A+HLA ++N +    LLV  G A+++ Q     +TALHLAVE
Sbjct: 617 SKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ-QTALHLAVE 675

Query: 696 HDNISLAGCLLLEGDAHVDSTTYDGTTPLHIA 727
             +  +   LL+   A +D    DG TPLH A
Sbjct: 676 RQHTQIVR-LLVRAGAKLDIQDKDGDTPLHEA 706



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 54/196 (27%), Positives = 95/196 (48%), Gaps = 20/196 (10%)

Query: 557 SQLVRDLLEVT-SGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           SQL++ L E   SG ++++++             A        VEDLL+   D+ +  + 
Sbjct: 416 SQLLKKLFETQESGDLNEELVK------------AAANGDVAKVEDLLKR-PDVDVNGQC 462

Query: 616 -GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAA 674
            G++ +  A++ GH  +L +LLK     + ++  + DG  A+H A   +    + +L   
Sbjct: 463 AGHTAMQAASQNGHVDILKLLLKQN---VDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRG 519

Query: 675 GADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTR 734
            AD+NA+ ++  +T LH+AV   ++ +   LL  G  H      +G TPLH A  +    
Sbjct: 520 SADLNARNKRR-QTPLHIAVNKGHLQVVKTLLDFG-CHPSLQDSEGDTPLHDAISKKRDD 577

Query: 735 LAALLKAAGADPLVEN 750
           + A+L  AGAD  + N
Sbjct: 578 ILAVLLEAGADVTITN 593



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 39/116 (33%), Positives = 62/116 (53%), Gaps = 10/116 (8%)

Query: 515 NALFDYAVTGD---VKMLLAVQRHLTAVQDENGD--SVLHLAIIHLHSQLVRDLLEVTSG 569
           NAL   A+ G+   +++LL+       V ++  D  + LHLA ++ H ++    L V  G
Sbjct: 598 NALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE--LLVHQG 655

Query: 570 LISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAK 625
             + DI N+     QT LHLAV  +   +V  L+RAGA L + D+ G++ LH A +
Sbjct: 656 NANLDIQNVNQ---QTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 33/122 (27%), Positives = 54/122 (44%), Gaps = 11/122 (9%)

Query: 644 LLDHPNGD------GLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHD 697
           LL  P+ D      G  A+  A  +  +  L LL+    DV A+++   R   H A   +
Sbjct: 450 LLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDE 509

Query: 698 NISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFE---PL 754
              +   +L  G A +++      TPLHIA  +G  ++   L   G  P +++ E   PL
Sbjct: 510 GAVIE--VLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPL 567

Query: 755 YD 756
           +D
Sbjct: 568 HD 569


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 75/250 (30%), Positives = 109/250 (43%), Gaps = 39/250 (15%)

Query: 539 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDV 598
           V D +G S LH A+   H + V  LL   + L      N+ +   + PLH A      +V
Sbjct: 135 VADRSGRSALHHAVHSGHLETVNLLLNKGASL------NVCDKKERQPLHWAAFLGHLEV 188

Query: 599 VEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH-------------------- 638
           ++ L+  GADL   DR G  +LH AA  G  +V+  LL+                     
Sbjct: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY 248

Query: 639 ----------KKAALLLDHPNGDGLNAIHLAMMS-NSLPCLLLLVAAGADVNAQEQKSGR 687
                       A   ++ PN  G   +H+A +S N   CL LLV  GADVN Q  K G+
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ-SKEGK 307

Query: 688 TALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPL 747
           + LH+A  H   + +  +L++  + +D     G TPLH+AA  G   L + L   GAD  
Sbjct: 308 SPLHMAAIHGRFTRSQ-ILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTA 366

Query: 748 VENFEPLYDL 757
                 ++ L
Sbjct: 367 RRGIHDMFPL 376



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 76/264 (28%), Positives = 118/264 (44%), Gaps = 37/264 (14%)

Query: 546 SVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRA 605
           S LHLA  + H + ++ L E    L      ++R+   +T L LA      + VE L   
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNL------DVRDHKGRTALFLATERGSTECVEVLTAH 640

Query: 606 GADLSLLDRLGN-SVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNS 664
           GA   + +R    + LH AA  GH   L +L+   + A + D  +  G   + LA+M+  
Sbjct: 641 GASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGH 700

Query: 665 LPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC-----LLLEGDAHVDSTTYD 719
           + C+ LL+  G+  +A + + GRTALH        ++ GC      LL+ DA V    + 
Sbjct: 701 VDCVHLLLEKGSTADAADLR-GRTALHRG------AVTGCEDCLAALLDHDAFVLCRDFK 753

Query: 720 GTTPLHIAAGRGSTR-LAALLKAA-GADPL-----VENFEPLYDLDDSWENAGEDEGVVP 772
           G TP+H+A+  G T  L  LL+AA   DPL        + P++     W +    E    
Sbjct: 754 GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMH-----WASYTGHEDC-- 806

Query: 773 GTTPLDMATSWQVFDILNGKPYEP 796
               L++      F  L G P+ P
Sbjct: 807 ----LELLLEHSPFSYLEGNPFTP 826



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 59/185 (31%), Positives = 90/185 (48%), Gaps = 5/185 (2%)

Query: 561 RDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVL 620
           RD+ EV S L   + IN+ +   +TPLH A       +++ LL +GA+++  D L  + L
Sbjct: 19  RDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPL 78

Query: 621 HLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNA 680
           H AA   ++KVL +LL H       D         +H+A  + +  C   L    + +N 
Sbjct: 79  HRAAASRNEKVLGLLLAHSADVNARDKL---WQTPLHVAAANRATKCAEALAPLLSSLNV 135

Query: 681 QEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLK 740
            + +SGR+ALH AV   ++     LL +G A ++        PLH AA  G   +  LL 
Sbjct: 136 AD-RSGRSALHHAVHSGHLETVNLLLNKG-ASLNVCDKKERQPLHWAAFLGHLEVLKLLV 193

Query: 741 AAGAD 745
           A GAD
Sbjct: 194 ARGAD 198



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 62/222 (27%), Positives = 103/222 (46%), Gaps = 28/222 (12%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++ G + LH+A +  +  L  +LL V +G      +N ++   ++PLH+A I  +    +
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELL-VNNGAD----VNYQSKEGKSPLHMAAIHGRFTRSQ 323

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAM 660
            L++ G+++   D+ GN+ LH+AA+ GH+ ++S L+ +              +  +HLA+
Sbjct: 324 ILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTA---RRGIHDMFPLHLAV 380

Query: 661 MSNSLPCLLLL------------------VAAGADVNAQEQKSGRTALHLAVEHDNISLA 702
           +     C   L                  ++AG D+N  +   GRT LH A    N+   
Sbjct: 381 LFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD-NLGRTCLHAAASGGNVECL 439

Query: 703 GCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
             LLL   A +      G TPLH AA  GS + A  L  AGA
Sbjct: 440 N-LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 70/240 (29%), Positives = 101/240 (42%), Gaps = 37/240 (15%)

Query: 536 LTAVQDENGDSVLHLAIIHLHSQLVRDLLE---------------------------VTS 568
           +T V D  G + L LAI++ H   V  LLE                           + +
Sbjct: 680 ITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAA 739

Query: 569 GLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDR----LGNSVLHLAA 624
            L  D  +  R+   +TP+HLA       V+  LL+A      LD      G S +H A+
Sbjct: 740 LLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWAS 799

Query: 625 KEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSN-SLPCLLLLVAAGADVNAQEQ 683
             GH+  L +LL+H   + L     G+    +H A+++N      +LL A GA +     
Sbjct: 800 YTGHEDCLELLLEHSPFSYL----EGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRD 855

Query: 684 KSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAG 743
             GRT LH A   DN+S    +LL+  A V++T + G T L  AA  G T     L   G
Sbjct: 856 AKGRTPLHAAAFADNVS-GLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 77/279 (27%), Positives = 121/279 (43%), Gaps = 20/279 (7%)

Query: 470 QEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKML 529
           Q P    + NG V   +    K  +A   D            R   AL   AVTG    L
Sbjct: 689 QTPLMLAIMNGHVDCVHLLLEKGSTADAAD-----------LRGRTALHRGAVTGCEDCL 737

Query: 530 LAVQRHLTAV--QDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLY-QTP 586
            A+  H   V  +D  G + +HLA    H+ ++R LL+     +S D ++   D    +P
Sbjct: 738 AALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAA---LSTDPLDAGVDYSGYSP 794

Query: 587 LHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLD 646
           +H A  T  ED +E LL   +  S L+    + LH A     D    +LL     A +++
Sbjct: 795 MHWASYTGHEDCLE-LLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLG-ALGAKIVN 852

Query: 647 HPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
             +  G   +H A  ++++  L +L+   A+VNA +  +GRTAL  A E+   +    LL
Sbjct: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDH-TGRTALMTAAENGQTAAVEFLL 911

Query: 707 LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD 745
             G A +     +  T LH+A  +G  + A ++ A   D
Sbjct: 912 YRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 52/179 (29%), Positives = 80/179 (44%), Gaps = 11/179 (6%)

Query: 548 LHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGA 607
           LH A+I+        LL    G +   I+N R+   +TPLH A        +  LL+  A
Sbjct: 827 LHCAVINNQDSTTEMLL----GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQA 882

Query: 608 DLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPC 667
           +++  D  G + L  AA+ G    +  LL   KA L +   N +   A+HLA       C
Sbjct: 883 EVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKN--TALHLACSKGHEKC 940

Query: 668 LLLLVAAGAD---VNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTP 723
            L+++A   D   +NA    + +  LH+A  +   S+   LL  G A V +   +G TP
Sbjct: 941 ALMILAETQDLGLINA-TNSALQMPLHIAARNGLASVVQALLSHG-ATVLAVDEEGHTP 997



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 47/145 (32%), Positives = 68/145 (46%), Gaps = 2/145 (1%)

Query: 599 VEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHL 658
           +E LL  GAD SL DR G + +H AA  G+ + L +LL+      L D  +   ++ +HL
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE-MSFNCLEDVESTIPVSPLHL 591

Query: 659 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 718
           A  +     L  L     +++ ++ K GRTAL LA E  +      L   G + +     
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHK-GRTALFLATERGSTECVEVLTAHGASALIKERK 650

Query: 719 DGTTPLHIAAGRGSTRLAALLKAAG 743
              TPLH AA  G T    LL  +G
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSG 675



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 51/181 (28%), Positives = 83/181 (45%), Gaps = 10/181 (5%)

Query: 528  MLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPL 587
            +L A+   +   +D  G + LH A    +   +R LL+  +       +N  +   +T L
Sbjct: 842  LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE------VNATDHTGRTAL 895

Query: 588  HLAVITKQEDVVEDLLRAG-ADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLD 646
              A    Q   VE LL  G ADL++LD   N+ LHLA  +GH+K   ++L   +   L++
Sbjct: 896  MTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLIN 955

Query: 647  HPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
              N      +H+A  +     +  L++ GA V A +++    AL  A   D   +A CL 
Sbjct: 956  ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKD---VADCLA 1012

Query: 707  L 707
            L
Sbjct: 1013 L 1013



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 55/179 (30%), Positives = 74/179 (41%), Gaps = 17/179 (9%)

Query: 574 DIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLS 633
           DI ++ +   QTPL LA++    D V  LL  G+     D  G + LH  A  G +  L+
Sbjct: 679 DITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLA 738

Query: 634 ILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGAD---VNAQEQKSGRTAL 690
            LL H    L  D     G   IHLA        L  L+ A      ++A    SG + +
Sbjct: 739 ALLDHDAFVLCRDF---KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPM 795

Query: 691 HLA--VEHDNISLAGCLLLEGDAHVDSTTYDGT--TPLHIAA-GRGSTRLAALLKAAGA 744
           H A    H++      LLLE   H   +  +G   TPLH A      +    LL A GA
Sbjct: 796 HWASYTGHEDCLE---LLLE---HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGA 848



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 40/142 (28%), Positives = 62/142 (43%), Gaps = 9/142 (6%)

Query: 523  TGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDL 582
            T  V+ LL   +    V DEN ++ LHLA    H +    +L  T  L    +IN  N  
Sbjct: 904  TAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL---GLINATNSA 960

Query: 583  YQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNS-VLHLAAKEGHDKVLSILLKHKKA 641
             Q PLH+A       VV+ LL  GA +  +D  G++  L  A  +     L+++L   K 
Sbjct: 961  LQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMK- 1019

Query: 642  ALLLDHPNGDGLNAIHLAMMSN 663
                  P  D ++    +++ N
Sbjct: 1020 ----PFPPKDAVSPFSFSLLKN 1037



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 59/222 (26%), Positives = 86/222 (38%), Gaps = 28/222 (12%)

Query: 555 LHSQLVRDLLEVTSGLISDDIINMRNDLY-QTPLHLAVITKQEDVVEDLLRAGADLSLLD 613
           LH+      +E  + L+S      R D + +TPLH A           L+ AGA ++  D
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486

Query: 614 RLGNSVLHLAA------------KEGHDKVLSILLKHKK-------AALLLDH------P 648
             G S LH AA               HD      LK  +          LLD+       
Sbjct: 487 CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLR 546

Query: 649 NGDGLNAIHLAMMSNSLPCLLLLVAAGAD-VNAQEQKSGRTALHLAVEHDNISLAGCLLL 707
           +  G  A+H A    +   L LL+    + +   E     + LHLA  + +   A   L 
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE-ALKTLA 605

Query: 708 EGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVE 749
           E   ++D   + G T L +A  RGST    +L A GA  L++
Sbjct: 606 ETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIK 647


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 74/222 (33%), Positives = 116/222 (52%), Gaps = 11/222 (4%)

Query: 525 DVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQ 584
           DV  LL  +R       +NG + LH+A  H  +Q V  LL +  G  +      +N    
Sbjct: 556 DVAKLLLQRRAAADSAGKNGLTPLHVAA-HYDNQKVA-LLLLEKG--ASPHATAKNGY-- 609

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A    Q  +   LL  GA+ +++ + G + LHLA++EGH  ++++LL  K A + 
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL-DKGANIH 668

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           +      GL ++HLA   + +    +L   GAD +A   K G T L +A  + N+ +   
Sbjct: 669 MS--TKSGLTSLHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIVACHYGNVKMVNF 725

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           LL +G A+V++ T +G TPLH AA +G T +  +L   GA P
Sbjct: 726 LLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 61/161 (37%), Positives = 87/161 (54%), Gaps = 5/161 (3%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH++    Q DV   LL AGA  SL  + G + LH+AAK G   V  +LL+ + AA  
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA-- 568

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
            D    +GL  +H+A   ++    LLL+  GA  +A   K+G T LH+A + + + +A  
Sbjct: 569 -DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIAST 626

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD 745
           LL  G A  +  T  G TPLH+A+  G T +  LL   GA+
Sbjct: 627 LLNYG-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 71/236 (30%), Positives = 114/236 (48%), Gaps = 40/236 (16%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++NG + LHLA    H  LV++LL   S +  D      N    T LH+A +  Q +VV+
Sbjct: 40  NQNGLNALHLAAKEGHVGLVQELLGRGSSV--DSATKKGN----TALHIASLAGQAEVVK 93

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLK----------------------- 637
            L++ GA+++   + G + L++AA+E H  V+  LL+                       
Sbjct: 94  VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 153

Query: 638 HKKAALLLDHPNGDG---LNAIHLAMMSNSLPCLLLLVAAGADVNAQEQ-------KSGR 687
           H +A  +L   +  G   L A+H+A   +      LL+    + + Q +       +SG 
Sbjct: 154 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 213

Query: 688 TALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAG 743
           T LH+A  + N+++A  LLL   A VD T  +G TPLH+A+ RG+T +  LL   G
Sbjct: 214 TPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268



 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 88/301 (29%), Positives = 142/301 (47%), Gaps = 29/301 (9%)

Query: 501 LFLEKAMQLAKRHANAL--FDYAVTGD-VKMLLAVQRHLTAVQDENGD--SVLHLAIIHL 555
           L LE+   L  R  N L     A  GD V+ +  + +H   V D   D  + LH+A    
Sbjct: 296 LLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCG 355

Query: 556 HSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           H ++ + LL+  +        N R     TPLH+A    +  V+E L++ GA +  +   
Sbjct: 356 HYRVTKLLLDKRANP------NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 409

Query: 616 GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG 675
           G + +H+AA  GH  ++ +LL++  +    D  N  G  A+H+A  +  +  +  L+  G
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASP---DVTNIRGETALHMAARAGQVEVVRCLLRNG 466

Query: 676 ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRL 735
           A V+A+ ++  +T LH+A       +   LLL+  AH D+ T +G TPLHI+A  G   +
Sbjct: 467 ALVDARAREE-QTPLHIASRLGKTEIVQ-LLLQHMAHPDAATTNGYTPLHISAREGQVDV 524

Query: 736 AALLKAAGADPLV---ENFEPLY------DLDDS----WENAGEDEGVVPGTTPLDMATS 782
           A++L  AGA   +   + F PL+       LD +       A  D     G TPL +A  
Sbjct: 525 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584

Query: 783 W 783
           +
Sbjct: 585 Y 585



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 71/208 (34%), Positives = 105/208 (50%), Gaps = 11/208 (5%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A    ++ +V+ LL+   G I       R+ L  TPLH A  +  + VVE L
Sbjct: 244 NGITPLHVASKRGNTNMVKLLLD-RGGQID---AKTRDGL--TPLHCAARSGHDQVVELL 297

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L  GA L    + G S LH+AA+  H + +  LL+HK     +D    D L A+H+A   
Sbjct: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP---VDDVTLDYLTALHVAAHC 354

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
                  LL+   A+ NA+   +G T LH+A + + I +   LL++  A + + T  G T
Sbjct: 355 GHYRVTKLLLDKRANPNAR-ALNGFTPLHIACKKNRIKVME-LLVKYGASIQAITESGLT 412

Query: 723 PLHIAAGRGSTRLAALLKAAGADPLVEN 750
           P+H+AA  G   +  LL   GA P V N
Sbjct: 413 PIHVAAFMGHLNIVLLLLQNGASPDVTN 440



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 5/143 (3%)

Query: 597 DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAI 656
           D V + L+ G D++  ++ G + LHLAAKEGH  ++  LL    +   +D     G  A+
Sbjct: 24  DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSATKKGNTAL 80

Query: 657 HLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDST 716
           H+A ++     + +LV  GA++NAQ Q +G T L++A + ++I +    LLE  A+  + 
Sbjct: 81  HIASLAGQAEVVKVLVKEGANINAQSQ-NGFTPLYMAAQENHIDVVK-YLLENGANQSTA 138

Query: 717 TYDGTTPLHIAAGRGSTRLAALL 739
           T DG TPL +A  +G  +  A+L
Sbjct: 139 TEDGFTPLAVALQQGHNQAVAIL 161



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 69/232 (29%), Positives = 103/232 (44%), Gaps = 14/232 (6%)

Query: 509 LAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTS 568
           L   H  A +D      + +      H TA   +NG + LH+A      Q+   LL   +
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATA---KNGYTPLHIAAKKNQMQIASTLLNYGA 632

Query: 569 GLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGH 628
                +I+  +     TPLHLA      D+V  LL  GA++ +  + G + LHLAA+E  
Sbjct: 633 ---ETNIVTKQG---VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 686

Query: 629 DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRT 688
             V  IL KH       D     G   + +A    ++  +  L+  GA+VNA+  K+G T
Sbjct: 687 VNVADILTKHGADQ---DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT-KNGYT 742

Query: 689 ALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLK 740
            LH A +  +  +   LL  G A  ++TT +G T L IA   G   +   LK
Sbjct: 743 PLHQAAQQGHTHIINVLLQHG-AKPNATTANGNTALAIAKRLGYISVVDTLK 793



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 61/226 (26%), Positives = 108/226 (47%), Gaps = 22/226 (9%)

Query: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLE--VTSGLISDDIINMRNDLY 583
           VK+L+    ++ A Q +NG + L++A    H  +V+ LLE        ++D         
Sbjct: 92  VKVLVKEGANINA-QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGF------- 143

Query: 584 QTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHK---- 639
            TPL +A+       V  LL    +     ++    LH+AA++   K  ++LL++     
Sbjct: 144 -TPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 198

Query: 640 -KAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 698
            ++ ++++     G   +H+A    ++    LL+  GA V+    ++G T LH+A +  N
Sbjct: 199 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGN 257

Query: 699 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
            ++   LLL+    +D+ T DG TPLH AA  G  ++  LL   GA
Sbjct: 258 TNMVK-LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 302



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 55/205 (26%), Positives = 86/205 (41%), Gaps = 40/205 (19%)

Query: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
           IN  N      LHLA       +V++LL  G+ +    + GN+ LH+A+  G  +V+ +L
Sbjct: 36  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95

Query: 636 LKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGAD------------------ 677
           +K       ++  + +G   +++A   N +  +  L+  GA+                  
Sbjct: 96  VKE---GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 152

Query: 678 ----------VNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVD--------STTYD 719
                      N  + K    ALH+A   D+   A  LLL+ D + D         TT  
Sbjct: 153 GHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA-ALLLQNDHNADVQSKMMVNRTTES 211

Query: 720 GTTPLHIAAGRGSTRLAALLKAAGA 744
           G TPLHIAA  G+  +A LL   GA
Sbjct: 212 GFTPLHIAAHYGNVNVATLLLNRGA 236



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 42/136 (30%), Positives = 71/136 (52%), Gaps = 10/136 (7%)

Query: 623 AAKEGH-DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQ 681
           AA+ G+ DKV+  L    K  + ++  N +GLNA+HLA     +  +  L+  G+ V++ 
Sbjct: 17  AARAGNLDKVVEYL----KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72

Query: 682 EQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKA 741
            +K G TALH+A       +   L+ EG A++++ + +G TPL++AA      +   L  
Sbjct: 73  TKK-GNTALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130

Query: 742 AGADPLV---ENFEPL 754
            GA+      + F PL
Sbjct: 131 NGANQSTATEDGFTPL 146



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 34/100 (34%), Positives = 51/100 (51%), Gaps = 5/100 (5%)

Query: 659 AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTY 718
           A  + +L  ++  +  G D+N   Q +G  ALHLA +  ++ L   LL  G + VDS T 
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQ-NGLNALHLAAKEGHVGLVQELLGRGSS-VDSATK 74

Query: 719 DGTTPLHIAAGRGSTRLAALLKAAGADPLVEN---FEPLY 755
            G T LHIA+  G   +  +L   GA+   ++   F PLY
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 114


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 74/222 (33%), Positives = 116/222 (52%), Gaps = 11/222 (4%)

Query: 525 DVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQ 584
           DV  LL  +R       +NG + LH+A  H  +Q V  LL +  G  +      +N    
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAA-HYDNQKVA-LLLLEKG--ASPHATAKNGY-- 630

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A    Q  +   LL  GA+ +++ + G + LHLA++EGH  ++++LL  K A + 
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL-DKGANIH 689

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           +      GL ++HLA   + +    +L   GAD +A   K G T L +A  + N+ +   
Sbjct: 690 MS--TKSGLTSLHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIVACHYGNVKMVNF 746

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           LL +G A+V++ T +G TPLH AA +G T +  +L   GA P
Sbjct: 747 LLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 61/161 (37%), Positives = 87/161 (54%), Gaps = 5/161 (3%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH++    Q DV   LL AGA  SL  + G + LH+AAK G   V  +LL+ + AA  
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA-- 589

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
            D    +GL  +H+A   ++    LLL+  GA  +A   K+G T LH+A + + + +A  
Sbjct: 590 -DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIAST 647

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD 745
           LL  G A  +  T  G TPLH+A+  G T +  LL   GA+
Sbjct: 648 LLNYG-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 71/236 (30%), Positives = 114/236 (48%), Gaps = 40/236 (16%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++NG + LHLA    H  LV++LL   S +  D      N    T LH+A +  Q +VV+
Sbjct: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSV--DSATKKGN----TALHIASLAGQAEVVK 114

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLK----------------------- 637
            L++ GA+++   + G + L++AA+E H  V+  LL+                       
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174

Query: 638 HKKAALLLDHPNGDG---LNAIHLAMMSNSLPCLLLLVAAGADVNAQEQ-------KSGR 687
           H +A  +L   +  G   L A+H+A   +      LL+    + + Q +       +SG 
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234

Query: 688 TALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAG 743
           T LH+A  + N+++A  LLL   A VD T  +G TPLH+A+ RG+T +  LL   G
Sbjct: 235 TPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289



 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 88/301 (29%), Positives = 142/301 (47%), Gaps = 29/301 (9%)

Query: 501 LFLEKAMQLAKRHANAL--FDYAVTGD-VKMLLAVQRHLTAVQDENGD--SVLHLAIIHL 555
           L LE+   L  R  N L     A  GD V+ +  + +H   V D   D  + LH+A    
Sbjct: 317 LLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCG 376

Query: 556 HSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           H ++ + LL+  +        N R     TPLH+A    +  V+E L++ GA +  +   
Sbjct: 377 HYRVTKLLLDKRANP------NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430

Query: 616 GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG 675
           G + +H+AA  GH  ++ +LL++  +    D  N  G  A+H+A  +  +  +  L+  G
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASP---DVTNIRGETALHMAARAGQVEVVRCLLRNG 487

Query: 676 ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRL 735
           A V+A+ ++  +T LH+A       +   LLL+  AH D+ T +G TPLHI+A  G   +
Sbjct: 488 ALVDARAREE-QTPLHIASRLGKTEIVQ-LLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 736 AALLKAAGADPLV---ENFEPLY------DLDDS----WENAGEDEGVVPGTTPLDMATS 782
           A++L  AGA   +   + F PL+       LD +       A  D     G TPL +A  
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605

Query: 783 W 783
           +
Sbjct: 606 Y 606



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 71/208 (34%), Positives = 105/208 (50%), Gaps = 11/208 (5%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A    ++ +V+ LL+   G I       R+ L  TPLH A  +  + VVE L
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLD-RGGQID---AKTRDGL--TPLHCAARSGHDQVVELL 318

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L  GA L    + G S LH+AA+  H + +  LL+HK     +D    D L A+H+A   
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP---VDDVTLDYLTALHVAAHC 375

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
                  LL+   A+ NA+   +G T LH+A + + I +   LL++  A + + T  G T
Sbjct: 376 GHYRVTKLLLDKRANPNAR-ALNGFTPLHIACKKNRIKVME-LLVKYGASIQAITESGLT 433

Query: 723 PLHIAAGRGSTRLAALLKAAGADPLVEN 750
           P+H+AA  G   +  LL   GA P V N
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTN 461



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 5/143 (3%)

Query: 597 DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAI 656
           D V + L+ G D++  ++ G + LHLAAKEGH  ++  LL    +   +D     G  A+
Sbjct: 45  DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSATKKGNTAL 101

Query: 657 HLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDST 716
           H+A ++     + +LV  GA++NAQ Q +G T L++A + ++I +    LLE  A+  + 
Sbjct: 102 HIASLAGQAEVVKVLVKEGANINAQSQ-NGFTPLYMAAQENHIDVVK-YLLENGANQSTA 159

Query: 717 TYDGTTPLHIAAGRGSTRLAALL 739
           T DG TPL +A  +G  +  A+L
Sbjct: 160 TEDGFTPLAVALQQGHNQAVAIL 182



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 69/232 (29%), Positives = 103/232 (44%), Gaps = 14/232 (6%)

Query: 509 LAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTS 568
           L   H  A +D      + +      H TA   +NG + LH+A      Q+   LL   +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATA---KNGYTPLHIAAKKNQMQIASTLLNYGA 653

Query: 569 GLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGH 628
                +I+  +     TPLHLA      D+V  LL  GA++ +  + G + LHLAA+E  
Sbjct: 654 ---ETNIVTKQG---VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707

Query: 629 DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRT 688
             V  IL KH       D     G   + +A    ++  +  L+  GA+VNA+  K+G T
Sbjct: 708 VNVADILTKHGADQ---DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT-KNGYT 763

Query: 689 ALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLK 740
            LH A +  +  +   LL  G A  ++TT +G T L IA   G   +   LK
Sbjct: 764 PLHQAAQQGHTHIINVLLQHG-AKPNATTANGNTALAIAKRLGYISVVDTLK 814



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 61/226 (26%), Positives = 108/226 (47%), Gaps = 22/226 (9%)

Query: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLE--VTSGLISDDIINMRNDLY 583
           VK+L+    ++ A Q +NG + L++A    H  +V+ LLE        ++D         
Sbjct: 113 VKVLVKEGANINA-QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGF------- 164

Query: 584 QTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHK---- 639
            TPL +A+       V  LL    +     ++    LH+AA++   K  ++LL++     
Sbjct: 165 -TPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 219

Query: 640 -KAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 698
            ++ ++++     G   +H+A    ++    LL+  GA V+    ++G T LH+A +  N
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGN 278

Query: 699 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
            ++   LLL+    +D+ T DG TPLH AA  G  ++  LL   GA
Sbjct: 279 TNMVK-LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 55/205 (26%), Positives = 86/205 (41%), Gaps = 40/205 (19%)

Query: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
           IN  N      LHLA       +V++LL  G+ +    + GN+ LH+A+  G  +V+ +L
Sbjct: 57  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116

Query: 636 LKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGAD------------------ 677
           +K       ++  + +G   +++A   N +  +  L+  GA+                  
Sbjct: 117 VKE---GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173

Query: 678 ----------VNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVD--------STTYD 719
                      N  + K    ALH+A   D+   A  LLL+ D + D         TT  
Sbjct: 174 GHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA-ALLLQNDHNADVQSKMMVNRTTES 232

Query: 720 GTTPLHIAAGRGSTRLAALLKAAGA 744
           G TPLHIAA  G+  +A LL   GA
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGA 257



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 42/136 (30%), Positives = 71/136 (52%), Gaps = 10/136 (7%)

Query: 623 AAKEGH-DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQ 681
           AA+ G+ DKV+  L    K  + ++  N +GLNA+HLA     +  +  L+  G+ V++ 
Sbjct: 38  AARAGNLDKVVEYL----KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 682 EQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKA 741
            +K G TALH+A       +   L+ EG A++++ + +G TPL++AA      +   L  
Sbjct: 94  TKK-GNTALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 742 AGADPLV---ENFEPL 754
            GA+      + F PL
Sbjct: 152 NGANQSTATEDGFTPL 167



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 38/112 (33%), Positives = 55/112 (49%), Gaps = 6/112 (5%)

Query: 648 PNGDGLNAIHL-AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
           P     NA  L A  + +L  ++  +  G D+N   Q +G  ALHLA +  ++ L   LL
Sbjct: 26  PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQ-NGLNALHLAAKEGHVGLVQELL 84

Query: 707 LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVEN---FEPLY 755
             G + VDS T  G T LHIA+  G   +  +L   GA+   ++   F PLY
Sbjct: 85  GRGSS-VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 74/222 (33%), Positives = 116/222 (52%), Gaps = 11/222 (4%)

Query: 525 DVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQ 584
           DV  LL  +R       +NG + LH+A  H  +Q V  LL +  G  +      +N    
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAA-HYDNQKVA-LLLLEKG--ASPHATAKNGY-- 630

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A    Q  +   LL  GA+ +++ + G + LHLA++EGH  ++++LL  K A + 
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL-DKGANIH 689

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           +      GL ++HLA   + +    +L   GAD +A   K G T L +A  + N+ +   
Sbjct: 690 MS--TKSGLTSLHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIVACHYGNVKMVNF 746

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           LL +G A+V++ T +G TPLH AA +G T +  +L   GA P
Sbjct: 747 LLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 61/161 (37%), Positives = 87/161 (54%), Gaps = 5/161 (3%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH++    Q DV   LL AGA  SL  + G + LH+AAK G   V  +LL+ + AA  
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA-- 589

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
            D    +GL  +H+A   ++    LLL+  GA  +A   K+G T LH+A + + + +A  
Sbjct: 590 -DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIAST 647

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD 745
           LL  G A  +  T  G TPLH+A+  G T +  LL   GA+
Sbjct: 648 LLNYG-AETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 71/236 (30%), Positives = 114/236 (48%), Gaps = 40/236 (16%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++NG + LHLA    H  LV++LL   S +  D      N    T LH+A +  Q +VV+
Sbjct: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSV--DSATKKGN----TALHIASLAGQAEVVK 114

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLK----------------------- 637
            L++ GA+++   + G + L++AA+E H  V+  LL+                       
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174

Query: 638 HKKAALLLDHPNGDG---LNAIHLAMMSNSLPCLLLLVAAGADVNAQEQ-------KSGR 687
           H +A  +L   +  G   L A+H+A   +      LL+    + + Q +       +SG 
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234

Query: 688 TALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAG 743
           T LH+A  + N+++A  LLL   A VD T  +G TPLH+A+ RG+T +  LL   G
Sbjct: 235 TPLHIAAHYGNVNVA-TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289



 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 88/301 (29%), Positives = 142/301 (47%), Gaps = 29/301 (9%)

Query: 501 LFLEKAMQLAKRHANAL--FDYAVTGD-VKMLLAVQRHLTAVQDENGD--SVLHLAIIHL 555
           L LE+   L  R  N L     A  GD V+ +  + +H   V D   D  + LH+A    
Sbjct: 317 LLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCG 376

Query: 556 HSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           H ++ + LL+  +        N R     TPLH+A    +  V+E L++ GA +  +   
Sbjct: 377 HYRVTKLLLDKRANP------NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430

Query: 616 GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG 675
           G + +H+AA  GH  ++ +LL++  +    D  N  G  A+H+A  +  +  +  L+  G
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASP---DVTNIRGETALHMAARAGQVEVVRCLLRNG 487

Query: 676 ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRL 735
           A V+A+ ++  +T LH+A       +   LLL+  AH D+ T +G TPLHI+A  G   +
Sbjct: 488 ALVDARAREE-QTPLHIASRLGKTEIVQ-LLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 736 AALLKAAGADPLV---ENFEPLY------DLDDS----WENAGEDEGVVPGTTPLDMATS 782
           A++L  AGA   +   + F PL+       LD +       A  D     G TPL +A  
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605

Query: 783 W 783
           +
Sbjct: 606 Y 606



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 71/208 (34%), Positives = 105/208 (50%), Gaps = 11/208 (5%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A    ++ +V+ LL+   G I       R+ L  TPLH A  +  + VVE L
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLD-RGGQID---AKTRDGL--TPLHCAARSGHDQVVELL 318

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L  GA L    + G S LH+AA+  H + +  LL+HK     +D    D L A+H+A   
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP---VDDVTLDYLTALHVAAHC 375

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
                  LL+   A+ NA+   +G T LH+A + + I +   LL++  A + + T  G T
Sbjct: 376 GHYRVTKLLLDKRANPNAR-ALNGFTPLHIACKKNRIKVME-LLVKYGASIQAITESGLT 433

Query: 723 PLHIAAGRGSTRLAALLKAAGADPLVEN 750
           P+H+AA  G   +  LL   GA P V N
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTN 461



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 5/143 (3%)

Query: 597 DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAI 656
           D V + L+ G D++  ++ G + LHLAAKEGH  ++  LL    +   +D     G  A+
Sbjct: 45  DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS---VDSATKKGNTAL 101

Query: 657 HLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDST 716
           H+A ++     + +LV  GA++NAQ Q +G T L++A + ++I +    LLE  A+  + 
Sbjct: 102 HIASLAGQAEVVKVLVKEGANINAQSQ-NGFTPLYMAAQENHIDVVK-YLLENGANQSTA 159

Query: 717 TYDGTTPLHIAAGRGSTRLAALL 739
           T DG TPL +A  +G  +  A+L
Sbjct: 160 TEDGFTPLAVALQQGHNQAVAIL 182



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 69/232 (29%), Positives = 103/232 (44%), Gaps = 14/232 (6%)

Query: 509 LAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTS 568
           L   H  A +D      + +      H TA   +NG + LH+A      Q+   LL   +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATA---KNGYTPLHIAAKKNQMQIASTLLNYGA 653

Query: 569 GLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGH 628
                +I+  +     TPLHLA      D+V  LL  GA++ +  + G + LHLAA+E  
Sbjct: 654 ---ETNIVTKQG---VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707

Query: 629 DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRT 688
             V  IL KH       D     G   + +A    ++  +  L+  GA+VNA+  K+G T
Sbjct: 708 VNVADILTKHGADQ---DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT-KNGYT 763

Query: 689 ALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLK 740
            LH A +  +  +   LL  G A  ++TT +G T L IA   G   +   LK
Sbjct: 764 PLHQAAQQGHTHIINVLLQHG-AKPNATTANGNTALAIAKRLGYISVVDTLK 814



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 61/226 (26%), Positives = 108/226 (47%), Gaps = 22/226 (9%)

Query: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLE--VTSGLISDDIINMRNDLY 583
           VK+L+    ++ A Q +NG + L++A    H  +V+ LLE        ++D         
Sbjct: 113 VKVLVKEGANINA-QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGF------- 164

Query: 584 QTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHK---- 639
            TPL +A+       V  LL    +     ++    LH+AA++   K  ++LL++     
Sbjct: 165 -TPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNAD 219

Query: 640 -KAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDN 698
            ++ ++++     G   +H+A    ++    LL+  GA V+    ++G T LH+A +  N
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGN 278

Query: 699 ISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
            ++   LLL+    +D+ T DG TPLH AA  G  ++  LL   GA
Sbjct: 279 TNMVK-LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 55/205 (26%), Positives = 86/205 (41%), Gaps = 40/205 (19%)

Query: 576 INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSIL 635
           IN  N      LHLA       +V++LL  G+ +    + GN+ LH+A+  G  +V+ +L
Sbjct: 57  INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116

Query: 636 LKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGAD------------------ 677
           +K       ++  + +G   +++A   N +  +  L+  GA+                  
Sbjct: 117 VKE---GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQ 173

Query: 678 ----------VNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVD--------STTYD 719
                      N  + K    ALH+A   D+   A  LLL+ D + D         TT  
Sbjct: 174 GHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA-ALLLQNDHNADVQSKMMVNRTTES 232

Query: 720 GTTPLHIAAGRGSTRLAALLKAAGA 744
           G TPLHIAA  G+  +A LL   GA
Sbjct: 233 GFTPLHIAAHYGNVNVATLLLNRGA 257



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 42/136 (30%), Positives = 71/136 (52%), Gaps = 10/136 (7%)

Query: 623 AAKEGH-DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQ 681
           AA+ G+ DKV+  L    K  + ++  N +GLNA+HLA     +  +  L+  G+ V++ 
Sbjct: 38  AARAGNLDKVVEYL----KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 682 EQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKA 741
            +K G TALH+A       +   L+ EG A++++ + +G TPL++AA      +   L  
Sbjct: 94  TKK-GNTALHIASLAGQAEVVKVLVKEG-ANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 742 AGADPLV---ENFEPL 754
            GA+      + F PL
Sbjct: 152 NGANQSTATEDGFTPL 167



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 38/112 (33%), Positives = 55/112 (49%), Gaps = 6/112 (5%)

Query: 648 PNGDGLNAIHL-AMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
           P     NA  L A  + +L  ++  +  G D+N   Q +G  ALHLA +  ++ L   LL
Sbjct: 26  PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQ-NGLNALHLAAKEGHVGLVQELL 84

Query: 707 LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVEN---FEPLY 755
             G + VDS T  G T LHIA+  G   +  +L   GA+   ++   F PLY
Sbjct: 85  GRGSS-VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY 135


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 73/233 (31%), Positives = 112/233 (48%), Gaps = 13/233 (5%)

Query: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
           VK+LL+   ++ A  D+     +H A    H ++V+  L V+ G      +  ++    T
Sbjct: 156 VKLLLSRGANINAF-DKKDRRAIHWAAYMGHIEVVK--LLVSHGAE----VTCKDKKSYT 208

Query: 586 PLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLL 645
           PLH A  +    VV+ LL  G D++  +  GN+ LH+A   G D V++ L+       ++
Sbjct: 209 PLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELID---CGAIV 265

Query: 646 DHPNGDGLNAIHLAMMS-NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           +  N  G   +H A  S +   CL LLV  GADVN  + K G+T LH+   H   S +  
Sbjct: 266 NQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN-MKSKDGKTPLHMTALHGRFSRSQT 324

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDL 757
           ++  G A +D    +G TPLHIAA  G   L   L  +GAD        ++ L
Sbjct: 325 IIQSG-AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPL 376



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 85/291 (29%), Positives = 129/291 (44%), Gaps = 23/291 (7%)

Query: 468 QDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVK 527
           +DQ      + NG+     A   K+E    QDN   EK   L   HA A   Y    ++ 
Sbjct: 7   RDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDN---EKRTPL---HAAA---YLGDAEII 57

Query: 528 MLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPL 587
            LL +       +D    + LH A+     + V+ LL+ ++       +N R+  +QTPL
Sbjct: 58  ELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD------VNARDKNWQTPL 111

Query: 588 HLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDH 647
           H+A   K     E L+   +++++ DR G + LH AA  GH +++ +LL         D 
Sbjct: 112 HIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDK 171

Query: 648 PNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLL 707
            +     AIH A     +  + LLV+ GA+V  +++KS  T LH A     IS+   LL 
Sbjct: 172 KD---RRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS-YTPLHAAASSGMISVVKYLLD 227

Query: 708 EGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVEN---FEPLY 755
            G    +   Y G TPLH+A   G   +   L   GA    +N   F PL+
Sbjct: 228 LGVDMNEPNAY-GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLH 277



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 62/201 (30%), Positives = 101/201 (50%), Gaps = 10/201 (4%)

Query: 546 SVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRA 605
           S LHLA  H H Q +  L++    L      ++RN   +TPL LA      + V+ L+  
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDL------DVRNSSGRTPLDLAAFKGHVECVDVLINQ 605

Query: 606 GADLSLLDR-LGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNS 664
           GA + + D  L  + +H AA  GH + L +L+ + +    +D  +G+G   + L++++  
Sbjct: 606 GASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGH 665

Query: 665 LPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPL 724
             C+  L+  GA+V+A++ K GRTALH      +      LL  G A        G TP+
Sbjct: 666 TDCVYSLLNKGANVDAKD-KWGRTALHRGAVTGHEECVDALLQHG-AKCLLRDSRGRTPI 723

Query: 725 HIAAGRGSTR-LAALLKAAGA 744
           H++A  G    L ALL++A +
Sbjct: 724 HLSAACGHIGVLGALLQSAAS 744



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 62/219 (28%), Positives = 101/219 (46%), Gaps = 37/219 (16%)

Query: 540 QDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVV 599
           ++E G + LH A    H  L  +LL V +G      +NM++   +TPLH+  +  +    
Sbjct: 268 KNEKGFTPLHFAAASTHGALCLELL-VGNGAD----VNMKSKDGKTPLHMTALHGRFSRS 322

Query: 600 EDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILL----------------------- 636
           + ++++GA +   D+ GN+ LH+AA+ GH+ +++ L+                       
Sbjct: 323 QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALS 382

Query: 637 -------KHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTA 689
                  K   +   +D P+  G   +H A    +L CL LL+  GAD N ++ K GR+ 
Sbjct: 383 GFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSP 441

Query: 690 LHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAA 728
           LH A  + N      L+  G A V+     G TPLH AA
Sbjct: 442 LHYAAANCNYQCLFALVGSG-ASVNDLDERGCTPLHYAA 479



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 61/194 (31%), Positives = 99/194 (51%), Gaps = 14/194 (7%)

Query: 539 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDV 598
           +QD NG + L L++++ H+  V  LL   +       ++ ++   +T LH   +T  E+ 
Sbjct: 648 IQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN------VDAKDKWGRTALHRGAVTGHEEC 701

Query: 599 VEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHP---NGDGLNA 655
           V+ LL+ GA   L D  G + +HL+A  GH  VL  LL  + AA +  +P   +  G  A
Sbjct: 702 VDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL--QSAASMDANPATADNHGYTA 759

Query: 656 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL-LEGDAHVD 714
           +H A  +    C+ LL+    +V  + + +  + LH AV +DN   A  L+   G + V+
Sbjct: 760 LHWACYNGHETCVELLLE--QEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVN 817

Query: 715 STTYDGTTPLHIAA 728
           +T   G TPLH AA
Sbjct: 818 ATDSKGRTPLHAAA 831



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 60/195 (30%), Positives = 91/195 (46%), Gaps = 11/195 (5%)

Query: 548 LHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGA 607
           +H A  + HS+ +R L+         + +++++   QTPL L+V+    D V  LL  GA
Sbjct: 621 IHAAATNGHSECLRLLI---GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677

Query: 608 DLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPC 667
           ++   D+ G + LH  A  GH++ +  LL+H    LL D     G   IHL+     +  
Sbjct: 678 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD---SRGRTPIHLSAACGHIGV 734

Query: 668 L--LLLVAAGADVN-AQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPL 724
           L  LL  AA  D N A     G TALH A  + + +    LLLE +     T  +  +PL
Sbjct: 735 LGALLQSAASMDANPATADNHGYTALHWACYNGHETCVE-LLLEQEV-FQKTEGNAFSPL 792

Query: 725 HIAAGRGSTRLAALL 739
           H A    +   A +L
Sbjct: 793 HCAVINDNEGAAEML 807



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 61/222 (27%), Positives = 103/222 (46%), Gaps = 15/222 (6%)

Query: 539 VQDENGDSVLHLAIIHLH--------SQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLA 590
           ++D+ G + +H +  + H        S+   D+L  TSG  +D + +  N    +PLHLA
Sbjct: 500 IRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSG--TDMLSDSDNRATISPLHLA 557

Query: 591 VITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNG 650
                   +E L+++  DL + +  G + L LAA +GH + + +L+    + L+ D+   
Sbjct: 558 AYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILK 617

Query: 651 DGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQK--SGRTALHLAVEHDNISLAGCLLLE 708
                IH A  +    CL LL+      NA + +  +G+T L L+V + +      LL +
Sbjct: 618 R--TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675

Query: 709 GDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVEN 750
           G A+VD+    G T LH  A  G       L   GA  L+ +
Sbjct: 676 G-ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 60/214 (28%), Positives = 90/214 (42%), Gaps = 14/214 (6%)

Query: 538 AVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQED 597
           A  D +G + LH A  + H   V  LLE        ++         +PLH AVI   E 
Sbjct: 750 ATADNHGYTALHWACYNGHETCVELLLE-------QEVFQKTEGNAFSPLHCAVINDNEG 802

Query: 598 VVEDLL-RAGADL-SLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNA 655
             E L+   GA + +  D  G + LH AA   H + L +LL H      +D     G   
Sbjct: 803 AAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVD---STGKTP 859

Query: 656 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVE--HDNISLAGCLLLEGDAHV 713
           + +A  +     + +LV++ +     +  S  TALHLA    H+  +L     +     +
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919

Query: 714 DSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPL 747
           ++T     TPLH+AA  G T +   L   GA  L
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVL 953



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 57/223 (25%), Positives = 101/223 (45%), Gaps = 22/223 (9%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           D+ G + LH A    + + +  LL   +        N ++   ++PLH A        + 
Sbjct: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADF------NKKDKFGRSPLHYAAANCNYQCLF 455

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHD-KVLSILLKHKKAALLLDHPNGDGLNAIH-- 657
            L+ +GA ++ LD  G + LH AA    D K L  LL++     + D     G NA+H  
Sbjct: 456 ALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK---QGYNAVHYS 512

Query: 658 --------LAMMSNSLPCLLLLVAAGAD-VNAQEQKSGRTALHLAVEHDNISLAGCLLLE 708
                   L ++++  P  +L+  +G D ++  + ++  + LHLA  H +   A  +L++
Sbjct: 513 AAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGH-HQALEVLVQ 571

Query: 709 GDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENF 751
               +D     G TPL +AA +G      +L   GA  LV+++
Sbjct: 572 SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDY 614



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 54/226 (23%), Positives = 97/226 (42%), Gaps = 15/226 (6%)

Query: 530 LAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHL 589
           L +++ +    + N  S LH A+I+ +      L++     +   I+N  +   +TPLH 
Sbjct: 774 LLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT----LGASIVNATDSKGRTPLHA 829

Query: 590 AVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPN 649
           A  T   + ++ LL   A ++ +D  G + L +AA+ G    + +L+    A L L   +
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889

Query: 650 GDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSG--RTALHLAVEHDNISLAGCLLL 707
            +   A+HLA         LL++    D N     +   +T LH+A  +    +   LL 
Sbjct: 890 KN--TALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLG 947

Query: 708 EGDAHVDSTTYDGTTPLHIAAGRGSTR------LAALLKAAGADPL 747
           +G A V +   +G TP    A            LA ++  + + PL
Sbjct: 948 KG-ASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPL 992



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 30/94 (31%), Positives = 46/94 (48%), Gaps = 3/94 (3%)

Query: 523 TGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDL 582
           T  V+ML++       +QD + ++ LHLA    H      +LE    +   ++IN  N  
Sbjct: 869 TNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILE---KITDRNLINATNAA 925

Query: 583 YQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLG 616
            QTPLH+A       VV++LL  GA +  +D  G
Sbjct: 926 LQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959


>gi|41281709 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, delta [Homo sapiens]
          Length = 313

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 80/254 (31%), Positives = 120/254 (47%), Gaps = 37/254 (14%)

Query: 529 LLAVQRHLTAVQDENGDSVLHLAI---IHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
           +LA+       QDE GD++LHL     +   +    ++L+V   L      ++R    +T
Sbjct: 34  MLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYRRL------DIREHKGKT 87

Query: 586 PLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLL 645
           PL +A    Q  +VEDLL  GA+ +  D  G SVLH+AA  G   VL  +L +    + L
Sbjct: 88  PLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVLLAVL-NSGVQVDL 146

Query: 646 DHPNGDGLNAIHLAMMS--------------------NSLPCLLLLVAAGADVNAQEQKS 685
           +  + +GL  +H A+++                    + L C+ +L+  GA+  +QE KS
Sbjct: 147 EARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHMLLQMGANHTSQEIKS 206

Query: 686 GRTALHLAVEHDNISLAGCL--LLEGDAHV-DSTTYDGTTPLHIAA----GRGSTRLAAL 738
            +T LHLAV+  N +L   L  L  GD     +    G T LH+AA    G     +   
Sbjct: 207 NKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHMAAALPPGPAQEAIVRH 266

Query: 739 LKAAGADPLVENFE 752
           L AAGADP + N E
Sbjct: 267 LLAAGADPTLRNLE 280



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 39/121 (32%), Positives = 60/121 (49%), Gaps = 6/121 (4%)

Query: 526 VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQT 585
           V MLL +  + T+ + ++  +VLHLA+   +  LV+ LLE+  G +    +NM+     T
Sbjct: 189 VHMLLQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLR-TFVNMKAH-GNT 246

Query: 586 PLHLAVI----TKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKA 641
            LH+A        QE +V  LL AGAD +L +      +HL       + L  LLK  + 
Sbjct: 247 ALHMAAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRV 306

Query: 642 A 642
           A
Sbjct: 307 A 307


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 73/220 (33%), Positives = 108/220 (49%), Gaps = 12/220 (5%)

Query: 527 KMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTP 586
           ++LL    H  A   +NG + LH+A+ H +  +V+ LL    G       N       TP
Sbjct: 586 ELLLERDAHPNAA-GKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWNG-----YTP 638

Query: 587 LHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLD 646
           LH+A    Q +V   LL+ G   +     G + LHLAA+EGH +++++LL  +    L  
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-- 696

Query: 647 HPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
             N  GL  +HL      +P   +L+  G  V+A   + G T LH+A  + NI L    L
Sbjct: 697 -GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVK-FL 753

Query: 707 LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           L+  A V++ T  G +PLH AA +G T +  LL   GA P
Sbjct: 754 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 64/209 (30%), Positives = 104/209 (49%), Gaps = 13/209 (6%)

Query: 545 DSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR 604
           ++ LH+A    H+++ + LL+  +       +N +    QTPLH A      ++V+ LL 
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAK------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 524

Query: 605 AGADLSLLDRLGNSVLHLAAKEGH-DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSN 663
             A+ +L    G++ LH+AA+EGH + VL++L K    A +       G   +H+A    
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKKGFTPLHVAAKYG 580

Query: 664 SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTP 723
            +    LL+   A  NA   K+G T LH+AV H+N+ +   LL  G +   S  ++G TP
Sbjct: 581 KVRVAELLLERDAHPNA-AGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTP 638

Query: 724 LHIAAGRGSTRLAALLKAAGADPLVENFE 752
           LHIAA +    +A  L   G     E+ +
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSANAESVQ 667



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 77/251 (30%), Positives = 113/251 (45%), Gaps = 16/251 (6%)

Query: 501 LFLEKAMQL---AKRHANALFDYAVTGDVKMLLAVQRHLTAVQ--DENGDSVLHLAIIHL 555
           L L++  Q+    K     L   A  G V++   +  H   +Q   +NG S +H+A    
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 349

Query: 556 HSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           H   VR LL+  + +  DDI       + TPLH+A       V + LL  GA  +     
Sbjct: 350 HLDCVRLLLQYDAEI--DDITLD----HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403

Query: 616 GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG 675
           G + LH+A K+ H +V+ +LL   K    +D     GL  +H+A     LP +  L+  G
Sbjct: 404 GFTPLHIACKKNHVRVMELLL---KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460

Query: 676 ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRL 735
           A  N    K   T LH+A    +  +A   LL+  A V++   D  TPLH AA  G T +
Sbjct: 461 ASPNVSNVKV-ETPLHMAARAGHTEVAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 518

Query: 736 AALLKAAGADP 746
             LL    A+P
Sbjct: 519 VKLLLENNANP 529



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 61/198 (30%), Positives = 99/198 (50%), Gaps = 11/198 (5%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A      ++ R LL+      ++ +  +      TPLHLA      ++V  L
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV------TPLHLAAQEGHAEMVALL 687

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L   A+ +L ++ G + LHL A+EGH  V  +L+KH    +++D     G   +H+A   
Sbjct: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH---GVMVDATTRMGYTPLHVASHY 744

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
            ++  +  L+   ADVNA+  K G + LH A +  +  +   LLL+  A  +  + DGTT
Sbjct: 745 GNIKLVKFLLQHQADVNAKT-KLGYSPLHQAAQQGHTDIV-TLLLKNGASPNEVSSDGTT 802

Query: 723 PLHIAAGRGSTRLAALLK 740
           PL IA   G   +  +LK
Sbjct: 803 PLAIAKRLGYISVTDVLK 820



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 66/230 (28%), Positives = 112/230 (48%), Gaps = 34/230 (14%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++NG + LHLA    H ++V +LL        + I+        T LH+A +  Q++VV 
Sbjct: 75  NQNGLNGLHLASKEGHVKMVVELLH------KEIILETTTKKGNTALHIAALAGQDEVVR 128

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH--------------KKAALLLD 646
           +L+  GA+++   + G + L++AA+E H +V+  LL++                 AL   
Sbjct: 129 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 188

Query: 647 HPNGDG------------LNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAV 694
           H N               L A+H+A  ++      +L+    + +    K+G T LH+A 
Sbjct: 189 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAA 247

Query: 695 EHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
            ++N+++A  LL  G A V+ T  +G TPLHIA+ RG+  +  LL   GA
Sbjct: 248 HYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 296



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 54/174 (31%), Positives = 92/174 (52%), Gaps = 8/174 (4%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A   +  +V + LL  GA ++   + G + LH+A++ G+  ++ +LL        
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQ 297

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           ++    D L  +H A  +  +    +L+  GA + A+  K+G + +H+A + D++     
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT-KNGLSPIHMAAQGDHLDCVR- 355

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP---LVENFEPLY 755
           LLL+ DA +D  T D  TPLH+AA  G  R+A +L   GA P    +  F PL+
Sbjct: 356 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 53/143 (37%), Positives = 83/143 (58%), Gaps = 5/143 (3%)

Query: 597 DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAI 656
           D   D LR G D++  ++ G + LHLA+KEGH K++  LL HK+  ++L+     G  A+
Sbjct: 59  DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE--IILETTTKKGNTAL 115

Query: 657 HLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDST 716
           H+A ++     +  LV  GA+VNAQ QK G T L++A + +++ +    LLE  A+ +  
Sbjct: 116 HIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVK-FLLENGANQNVA 173

Query: 717 TYDGTTPLHIAAGRGSTRLAALL 739
           T DG TPL +A  +G   + A L
Sbjct: 174 TEDGFTPLAVALQQGHENVVAHL 196



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 72/260 (27%), Positives = 113/260 (43%), Gaps = 37/260 (14%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A    H +++  LL+  +       I+   +   TPLH+A       +V++L
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGAS------IDAVTESGLTPLHVASFMGHLPIVKNL 456

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L+ GA  ++ +    + LH+AA+ GH +V   LL++K     ++    D    +H A   
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARI 513

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
                + LL+   A+ N     +G T LH+A    ++      LLE +A     T  G T
Sbjct: 514 GHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETV-LALLEKEASQACMTKKGFT 571

Query: 723 PLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATS 782
           PLH+AA  G  R+A LL    A P                 AG++     G TPL +A  
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHP---------------NAAGKN-----GLTPLHVAVH 611

Query: 783 WQVFDIL------NGKPYEP 796
               DI+       G P+ P
Sbjct: 612 HNNLDIVKLLLPRGGSPHSP 631


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 73/220 (33%), Positives = 108/220 (49%), Gaps = 12/220 (5%)

Query: 527 KMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTP 586
           ++LL    H  A   +NG + LH+A+ H +  +V+ LL    G       N       TP
Sbjct: 553 ELLLERDAHPNAA-GKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWNG-----YTP 605

Query: 587 LHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLD 646
           LH+A    Q +V   LL+ G   +     G + LHLAA+EGH +++++LL  +    L  
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-- 663

Query: 647 HPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
             N  GL  +HL      +P   +L+  G  V+A   + G T LH+A  + NI L    L
Sbjct: 664 -GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVK-FL 720

Query: 707 LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           L+  A V++ T  G +PLH AA +G T +  LL   GA P
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 64/209 (30%), Positives = 104/209 (49%), Gaps = 13/209 (6%)

Query: 545 DSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR 604
           ++ LH+A    H+++ + LL+  +       +N +    QTPLH A      ++V+ LL 
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAK------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 605 AGADLSLLDRLGNSVLHLAAKEGH-DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSN 663
             A+ +L    G++ LH+AA+EGH + VL++L K    A +       G   +H+A    
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKKGFTPLHVAAKYG 547

Query: 664 SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTP 723
            +    LL+   A  NA   K+G T LH+AV H+N+ +   LL  G +   S  ++G TP
Sbjct: 548 KVRVAELLLERDAHPNA-AGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTP 605

Query: 724 LHIAAGRGSTRLAALLKAAGADPLVENFE 752
           LHIAA +    +A  L   G     E+ +
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQ 634



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 77/251 (30%), Positives = 113/251 (45%), Gaps = 16/251 (6%)

Query: 501 LFLEKAMQL---AKRHANALFDYAVTGDVKMLLAVQRHLTAVQ--DENGDSVLHLAIIHL 555
           L L++  Q+    K     L   A  G V++   +  H   +Q   +NG S +H+A    
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316

Query: 556 HSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           H   VR LL+  + +  DDI       + TPLH+A       V + LL  GA  +     
Sbjct: 317 HLDCVRLLLQYDAEI--DDITLD----HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 616 GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG 675
           G + LH+A K+ H +V+ +LL   K    +D     GL  +H+A     LP +  L+  G
Sbjct: 371 GFTPLHIACKKNHVRVMELLL---KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 676 ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRL 735
           A  N    K   T LH+A    +  +A   LL+  A V++   D  TPLH AA  G T +
Sbjct: 428 ASPNVSNVKV-ETPLHMAARAGHTEVAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485

Query: 736 AALLKAAGADP 746
             LL    A+P
Sbjct: 486 VKLLLENNANP 496



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 61/198 (30%), Positives = 99/198 (50%), Gaps = 11/198 (5%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A      ++ R LL+      ++ +  +      TPLHLA      ++V  L
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV------TPLHLAAQEGHAEMVALL 654

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L   A+ +L ++ G + LHL A+EGH  V  +L+KH    +++D     G   +H+A   
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH---GVMVDATTRMGYTPLHVASHY 711

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
            ++  +  L+   ADVNA+  K G + LH A +  +  +   LLL+  A  +  + DGTT
Sbjct: 712 GNIKLVKFLLQHQADVNAKT-KLGYSPLHQAAQQGHTDIV-TLLLKNGASPNEVSSDGTT 769

Query: 723 PLHIAAGRGSTRLAALLK 740
           PL IA   G   +  +LK
Sbjct: 770 PLAIAKRLGYISVTDVLK 787



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 66/230 (28%), Positives = 112/230 (48%), Gaps = 34/230 (14%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++NG + LHLA    H ++V +LL        + I+        T LH+A +  Q++VV 
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLH------KEIILETTTKKGNTALHIAALAGQDEVVR 95

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH--------------KKAALLLD 646
           +L+  GA+++   + G + L++AA+E H +V+  LL++                 AL   
Sbjct: 96  ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155

Query: 647 HPNGDG------------LNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAV 694
           H N               L A+H+A  ++      +L+    + +    K+G T LH+A 
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAA 214

Query: 695 EHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
            ++N+++A  LL  G A V+ T  +G TPLHIA+ RG+  +  LL   GA
Sbjct: 215 HYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 54/174 (31%), Positives = 92/174 (52%), Gaps = 8/174 (4%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A   +  +V + LL  GA ++   + G + LH+A++ G+  ++ +LL        
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQ 264

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           ++    D L  +H A  +  +    +L+  GA + A+  K+G + +H+A + D++     
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT-KNGLSPIHMAAQGDHLDCVR- 322

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP---LVENFEPLY 755
           LLL+ DA +D  T D  TPLH+AA  G  R+A +L   GA P    +  F PL+
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 53/143 (37%), Positives = 83/143 (58%), Gaps = 5/143 (3%)

Query: 597 DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAI 656
           D   D LR G D++  ++ G + LHLA+KEGH K++  LL HK+  ++L+     G  A+
Sbjct: 26  DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE--IILETTTKKGNTAL 82

Query: 657 HLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDST 716
           H+A ++     +  LV  GA+VNAQ QK G T L++A + +++ +    LLE  A+ +  
Sbjct: 83  HIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVK-FLLENGANQNVA 140

Query: 717 TYDGTTPLHIAAGRGSTRLAALL 739
           T DG TPL +A  +G   + A L
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHL 163



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 72/260 (27%), Positives = 113/260 (43%), Gaps = 37/260 (14%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A    H +++  LL+  +       I+   +   TPLH+A       +V++L
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGAS------IDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L+ GA  ++ +    + LH+AA+ GH +V   LL++K     ++    D    +H A   
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARI 480

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
                + LL+   A+ N     +G T LH+A    ++      LLE +A     T  G T
Sbjct: 481 GHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETV-LALLEKEASQACMTKKGFT 538

Query: 723 PLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATS 782
           PLH+AA  G  R+A LL    A P                 AG++     G TPL +A  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHP---------------NAAGKN-----GLTPLHVAVH 578

Query: 783 WQVFDIL------NGKPYEP 796
               DI+       G P+ P
Sbjct: 579 HNNLDIVKLLLPRGGSPHSP 598


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 73/220 (33%), Positives = 108/220 (49%), Gaps = 12/220 (5%)

Query: 527 KMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTP 586
           ++LL    H  A   +NG + LH+A+ H +  +V+ LL    G       N       TP
Sbjct: 553 ELLLERDAHPNAA-GKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWNG-----YTP 605

Query: 587 LHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLD 646
           LH+A    Q +V   LL+ G   +     G + LHLAA+EGH +++++LL  +    L  
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-- 663

Query: 647 HPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
             N  GL  +HL      +P   +L+  G  V+A   + G T LH+A  + NI L    L
Sbjct: 664 -GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVK-FL 720

Query: 707 LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           L+  A V++ T  G +PLH AA +G T +  LL   GA P
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 64/209 (30%), Positives = 104/209 (49%), Gaps = 13/209 (6%)

Query: 545 DSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR 604
           ++ LH+A    H+++ + LL+  +       +N +    QTPLH A      ++V+ LL 
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAK------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 605 AGADLSLLDRLGNSVLHLAAKEGH-DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSN 663
             A+ +L    G++ LH+AA+EGH + VL++L K    A +       G   +H+A    
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKKGFTPLHVAAKYG 547

Query: 664 SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTP 723
            +    LL+   A  NA   K+G T LH+AV H+N+ +   LL  G +   S  ++G TP
Sbjct: 548 KVRVAELLLERDAHPNA-AGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTP 605

Query: 724 LHIAAGRGSTRLAALLKAAGADPLVENFE 752
           LHIAA +    +A  L   G     E+ +
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQ 634



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 77/251 (30%), Positives = 113/251 (45%), Gaps = 16/251 (6%)

Query: 501 LFLEKAMQL---AKRHANALFDYAVTGDVKMLLAVQRHLTAVQ--DENGDSVLHLAIIHL 555
           L L++  Q+    K     L   A  G V++   +  H   +Q   +NG S +H+A    
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316

Query: 556 HSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           H   VR LL+  + +  DDI       + TPLH+A       V + LL  GA  +     
Sbjct: 317 HLDCVRLLLQYDAEI--DDITLD----HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 616 GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG 675
           G + LH+A K+ H +V+ +LL   K    +D     GL  +H+A     LP +  L+  G
Sbjct: 371 GFTPLHIACKKNHVRVMELLL---KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 676 ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRL 735
           A  N    K   T LH+A    +  +A   LL+  A V++   D  TPLH AA  G T +
Sbjct: 428 ASPNVSNVKV-ETPLHMAARAGHTEVAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485

Query: 736 AALLKAAGADP 746
             LL    A+P
Sbjct: 486 VKLLLENNANP 496



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 61/198 (30%), Positives = 99/198 (50%), Gaps = 11/198 (5%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A      ++ R LL+      ++ +  +      TPLHLA      ++V  L
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV------TPLHLAAQEGHAEMVALL 654

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L   A+ +L ++ G + LHL A+EGH  V  +L+KH    +++D     G   +H+A   
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH---GVMVDATTRMGYTPLHVASHY 711

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
            ++  +  L+   ADVNA+  K G + LH A +  +  +   LLL+  A  +  + DGTT
Sbjct: 712 GNIKLVKFLLQHQADVNAKT-KLGYSPLHQAAQQGHTDIV-TLLLKNGASPNEVSSDGTT 769

Query: 723 PLHIAAGRGSTRLAALLK 740
           PL IA   G   +  +LK
Sbjct: 770 PLAIAKRLGYISVTDVLK 787



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 66/230 (28%), Positives = 112/230 (48%), Gaps = 34/230 (14%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++NG + LHLA    H ++V +LL        + I+        T LH+A +  Q++VV 
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLH------KEIILETTTKKGNTALHIAALAGQDEVVR 95

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH--------------KKAALLLD 646
           +L+  GA+++   + G + L++AA+E H +V+  LL++                 AL   
Sbjct: 96  ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155

Query: 647 HPNGDG------------LNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAV 694
           H N               L A+H+A  ++      +L+    + +    K+G T LH+A 
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAA 214

Query: 695 EHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
            ++N+++A  LL  G A V+ T  +G TPLHIA+ RG+  +  LL   GA
Sbjct: 215 HYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 54/174 (31%), Positives = 92/174 (52%), Gaps = 8/174 (4%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A   +  +V + LL  GA ++   + G + LH+A++ G+  ++ +LL        
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQ 264

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           ++    D L  +H A  +  +    +L+  GA + A+  K+G + +H+A + D++     
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT-KNGLSPIHMAAQGDHLDCVR- 322

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP---LVENFEPLY 755
           LLL+ DA +D  T D  TPLH+AA  G  R+A +L   GA P    +  F PL+
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 53/143 (37%), Positives = 83/143 (58%), Gaps = 5/143 (3%)

Query: 597 DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAI 656
           D   D LR G D++  ++ G + LHLA+KEGH K++  LL HK+  ++L+     G  A+
Sbjct: 26  DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE--IILETTTKKGNTAL 82

Query: 657 HLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDST 716
           H+A ++     +  LV  GA+VNAQ QK G T L++A + +++ +    LLE  A+ +  
Sbjct: 83  HIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVK-FLLENGANQNVA 140

Query: 717 TYDGTTPLHIAAGRGSTRLAALL 739
           T DG TPL +A  +G   + A L
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHL 163



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 72/260 (27%), Positives = 113/260 (43%), Gaps = 37/260 (14%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A    H +++  LL+  +       I+   +   TPLH+A       +V++L
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGAS------IDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L+ GA  ++ +    + LH+AA+ GH +V   LL++K     ++    D    +H A   
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARI 480

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
                + LL+   A+ N     +G T LH+A    ++      LLE +A     T  G T
Sbjct: 481 GHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETV-LALLEKEASQACMTKKGFT 538

Query: 723 PLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATS 782
           PLH+AA  G  R+A LL    A P                 AG++     G TPL +A  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHP---------------NAAGKN-----GLTPLHVAVH 578

Query: 783 WQVFDIL------NGKPYEP 796
               DI+       G P+ P
Sbjct: 579 HNNLDIVKLLLPRGGSPHSP 598


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 73/220 (33%), Positives = 108/220 (49%), Gaps = 12/220 (5%)

Query: 527 KMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTP 586
           ++LL    H  A   +NG + LH+A+ H +  +V+ LL    G       N       TP
Sbjct: 553 ELLLERDAHPNAA-GKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWNG-----YTP 605

Query: 587 LHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLD 646
           LH+A    Q +V   LL+ G   +     G + LHLAA+EGH +++++LL  +    L  
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-- 663

Query: 647 HPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
             N  GL  +HL      +P   +L+  G  V+A   + G T LH+A  + NI L    L
Sbjct: 664 -GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVK-FL 720

Query: 707 LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           L+  A V++ T  G +PLH AA +G T +  LL   GA P
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 64/209 (30%), Positives = 104/209 (49%), Gaps = 13/209 (6%)

Query: 545 DSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR 604
           ++ LH+A    H+++ + LL+  +       +N +    QTPLH A      ++V+ LL 
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAK------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 605 AGADLSLLDRLGNSVLHLAAKEGH-DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSN 663
             A+ +L    G++ LH+AA+EGH + VL++L K    A +       G   +H+A    
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKKGFTPLHVAAKYG 547

Query: 664 SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTP 723
            +    LL+   A  NA   K+G T LH+AV H+N+ +   LL  G +   S  ++G TP
Sbjct: 548 KVRVAELLLERDAHPNA-AGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTP 605

Query: 724 LHIAAGRGSTRLAALLKAAGADPLVENFE 752
           LHIAA +    +A  L   G     E+ +
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQ 634



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 77/251 (30%), Positives = 113/251 (45%), Gaps = 16/251 (6%)

Query: 501 LFLEKAMQL---AKRHANALFDYAVTGDVKMLLAVQRHLTAVQ--DENGDSVLHLAIIHL 555
           L L++  Q+    K     L   A  G V++   +  H   +Q   +NG S +H+A    
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316

Query: 556 HSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           H   VR LL+  + +  DDI       + TPLH+A       V + LL  GA  +     
Sbjct: 317 HLDCVRLLLQYDAEI--DDITLD----HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 616 GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG 675
           G + LH+A K+ H +V+ +LL   K    +D     GL  +H+A     LP +  L+  G
Sbjct: 371 GFTPLHIACKKNHVRVMELLL---KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 676 ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRL 735
           A  N    K   T LH+A    +  +A   LL+  A V++   D  TPLH AA  G T +
Sbjct: 428 ASPNVSNVKV-ETPLHMAARAGHTEVAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485

Query: 736 AALLKAAGADP 746
             LL    A+P
Sbjct: 486 VKLLLENNANP 496



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 61/198 (30%), Positives = 99/198 (50%), Gaps = 11/198 (5%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A      ++ R LL+      ++ +  +      TPLHLA      ++V  L
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV------TPLHLAAQEGHAEMVALL 654

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L   A+ +L ++ G + LHL A+EGH  V  +L+KH    +++D     G   +H+A   
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH---GVMVDATTRMGYTPLHVASHY 711

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
            ++  +  L+   ADVNA+  K G + LH A +  +  +   LLL+  A  +  + DGTT
Sbjct: 712 GNIKLVKFLLQHQADVNAKT-KLGYSPLHQAAQQGHTDIV-TLLLKNGASPNEVSSDGTT 769

Query: 723 PLHIAAGRGSTRLAALLK 740
           PL IA   G   +  +LK
Sbjct: 770 PLAIAKRLGYISVTDVLK 787



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 66/230 (28%), Positives = 112/230 (48%), Gaps = 34/230 (14%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++NG + LHLA    H ++V +LL        + I+        T LH+A +  Q++VV 
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLH------KEIILETTTKKGNTALHIAALAGQDEVVR 95

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH--------------KKAALLLD 646
           +L+  GA+++   + G + L++AA+E H +V+  LL++                 AL   
Sbjct: 96  ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155

Query: 647 HPNGDG------------LNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAV 694
           H N               L A+H+A  ++      +L+    + +    K+G T LH+A 
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAA 214

Query: 695 EHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
            ++N+++A  LL  G A V+ T  +G TPLHIA+ RG+  +  LL   GA
Sbjct: 215 HYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 54/174 (31%), Positives = 92/174 (52%), Gaps = 8/174 (4%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A   +  +V + LL  GA ++   + G + LH+A++ G+  ++ +LL        
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQ 264

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           ++    D L  +H A  +  +    +L+  GA + A+  K+G + +H+A + D++     
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT-KNGLSPIHMAAQGDHLDCVR- 322

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP---LVENFEPLY 755
           LLL+ DA +D  T D  TPLH+AA  G  R+A +L   GA P    +  F PL+
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 53/143 (37%), Positives = 83/143 (58%), Gaps = 5/143 (3%)

Query: 597 DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAI 656
           D   D LR G D++  ++ G + LHLA+KEGH K++  LL HK+  ++L+     G  A+
Sbjct: 26  DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE--IILETTTKKGNTAL 82

Query: 657 HLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDST 716
           H+A ++     +  LV  GA+VNAQ QK G T L++A + +++ +    LLE  A+ +  
Sbjct: 83  HIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVK-FLLENGANQNVA 140

Query: 717 TYDGTTPLHIAAGRGSTRLAALL 739
           T DG TPL +A  +G   + A L
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHL 163



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 72/260 (27%), Positives = 113/260 (43%), Gaps = 37/260 (14%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A    H +++  LL+  +       I+   +   TPLH+A       +V++L
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGAS------IDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L+ GA  ++ +    + LH+AA+ GH +V   LL++K     ++    D    +H A   
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARI 480

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
                + LL+   A+ N     +G T LH+A    ++      LLE +A     T  G T
Sbjct: 481 GHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETV-LALLEKEASQACMTKKGFT 538

Query: 723 PLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATS 782
           PLH+AA  G  R+A LL    A P                 AG++     G TPL +A  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHP---------------NAAGKN-----GLTPLHVAVH 578

Query: 783 WQVFDIL------NGKPYEP 796
               DI+       G P+ P
Sbjct: 579 HNNLDIVKLLLPRGGSPHSP 598


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 73/220 (33%), Positives = 108/220 (49%), Gaps = 12/220 (5%)

Query: 527 KMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTP 586
           ++LL    H  A   +NG + LH+A+ H +  +V+ LL    G       N       TP
Sbjct: 553 ELLLERDAHPNAA-GKNGLTPLHVAVHHNNLDIVKLLLP-RGGSPHSPAWNG-----YTP 605

Query: 587 LHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLD 646
           LH+A    Q +V   LL+ G   +     G + LHLAA+EGH +++++LL  +    L  
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-- 663

Query: 647 HPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLL 706
             N  GL  +HL      +P   +L+  G  V+A   + G T LH+A  + NI L    L
Sbjct: 664 -GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVASHYGNIKLVK-FL 720

Query: 707 LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP 746
           L+  A V++ T  G +PLH AA +G T +  LL   GA P
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 64/209 (30%), Positives = 104/209 (49%), Gaps = 13/209 (6%)

Query: 545 DSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLR 604
           ++ LH+A    H+++ + LL+  +       +N +    QTPLH A      ++V+ LL 
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAK------VNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 605 AGADLSLLDRLGNSVLHLAAKEGH-DKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSN 663
             A+ +L    G++ LH+AA+EGH + VL++L K    A +       G   +H+A    
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKKGFTPLHVAAKYG 547

Query: 664 SLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTP 723
            +    LL+   A  NA   K+G T LH+AV H+N+ +   LL  G +   S  ++G TP
Sbjct: 548 KVRVAELLLERDAHPNA-AGKNGLTPLHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTP 605

Query: 724 LHIAAGRGSTRLAALLKAAGADPLVENFE 752
           LHIAA +    +A  L   G     E+ +
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQ 634



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 77/251 (30%), Positives = 113/251 (45%), Gaps = 16/251 (6%)

Query: 501 LFLEKAMQL---AKRHANALFDYAVTGDVKMLLAVQRHLTAVQ--DENGDSVLHLAIIHL 555
           L L++  Q+    K     L   A  G V++   +  H   +Q   +NG S +H+A    
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316

Query: 556 HSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRL 615
           H   VR LL+  + +  DDI       + TPLH+A       V + LL  GA  +     
Sbjct: 317 HLDCVRLLLQYDAEI--DDITLD----HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 616 GNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAG 675
           G + LH+A K+ H +V+ +LL   K    +D     GL  +H+A     LP +  L+  G
Sbjct: 371 GFTPLHIACKKNHVRVMELLL---KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 676 ADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRL 735
           A  N    K   T LH+A    +  +A   LL+  A V++   D  TPLH AA  G T +
Sbjct: 428 ASPNVSNVKV-ETPLHMAARAGHTEVAK-YLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485

Query: 736 AALLKAAGADP 746
             LL    A+P
Sbjct: 486 VKLLLENNANP 496



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 61/198 (30%), Positives = 99/198 (50%), Gaps = 11/198 (5%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A      ++ R LL+      ++ +  +      TPLHLA      ++V  L
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV------TPLHLAAQEGHAEMVALL 654

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L   A+ +L ++ G + LHL A+EGH  V  +L+KH    +++D     G   +H+A   
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH---GVMVDATTRMGYTPLHVASHY 711

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
            ++  +  L+   ADVNA+  K G + LH A +  +  +   LLL+  A  +  + DGTT
Sbjct: 712 GNIKLVKFLLQHQADVNAKT-KLGYSPLHQAAQQGHTDIV-TLLLKNGASPNEVSSDGTT 769

Query: 723 PLHIAAGRGSTRLAALLK 740
           PL IA   G   +  +LK
Sbjct: 770 PLAIAKRLGYISVTDVLK 787



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 66/230 (28%), Positives = 112/230 (48%), Gaps = 34/230 (14%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           ++NG + LHLA    H ++V +LL        + I+        T LH+A +  Q++VV 
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLH------KEIILETTTKKGNTALHIAALAGQDEVVR 95

Query: 601 DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH--------------KKAALLLD 646
           +L+  GA+++   + G + L++AA+E H +V+  LL++                 AL   
Sbjct: 96  ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155

Query: 647 HPNGDG------------LNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAV 694
           H N               L A+H+A  ++      +L+    + +    K+G T LH+A 
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL-SKTGFTPLHIAA 214

Query: 695 EHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGA 744
            ++N+++A  LL  G A V+ T  +G TPLHIA+ RG+  +  LL   GA
Sbjct: 215 HYENLNVAQLLLNRG-ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 54/174 (31%), Positives = 92/174 (52%), Gaps = 8/174 (4%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPLH+A   +  +V + LL  GA ++   + G + LH+A++ G+  ++ +LL        
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQ 264

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGC 704
           ++    D L  +H A  +  +    +L+  GA + A+  K+G + +H+A + D++     
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT-KNGLSPIHMAAQGDHLDCVR- 322

Query: 705 LLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADP---LVENFEPLY 755
           LLL+ DA +D  T D  TPLH+AA  G  R+A +L   GA P    +  F PL+
Sbjct: 323 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 53/143 (37%), Positives = 83/143 (58%), Gaps = 5/143 (3%)

Query: 597 DVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAI 656
           D   D LR G D++  ++ G + LHLA+KEGH K++  LL HK+  ++L+     G  A+
Sbjct: 26  DKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL-HKE--IILETTTKKGNTAL 82

Query: 657 HLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDST 716
           H+A ++     +  LV  GA+VNAQ QK G T L++A + +++ +    LLE  A+ +  
Sbjct: 83  HIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVK-FLLENGANQNVA 140

Query: 717 TYDGTTPLHIAAGRGSTRLAALL 739
           T DG TPL +A  +G   + A L
Sbjct: 141 TEDGFTPLAVALQQGHENVVAHL 163



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 72/260 (27%), Positives = 113/260 (43%), Gaps = 37/260 (14%)

Query: 543 NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
           NG + LH+A    H +++  LL+  +       I+   +   TPLH+A       +V++L
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGAS------IDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 603 LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
           L+ GA  ++ +    + LH+AA+ GH +V   LL++K     ++    D    +H A   
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARI 480

Query: 663 NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
                + LL+   A+ N     +G T LH+A    ++      LLE +A     T  G T
Sbjct: 481 GHTNMVKLLLENNANPNL-ATTAGHTPLHIAAREGHVETV-LALLEKEASQACMTKKGFT 538

Query: 723 PLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATS 782
           PLH+AA  G  R+A LL    A P                 AG++     G TPL +A  
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHP---------------NAAGKN-----GLTPLHVAVH 578

Query: 783 WQVFDIL------NGKPYEP 796
               DI+       G P+ P
Sbjct: 579 HNNLDIVKLLLPRGGSPHSP 598


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 88/313 (28%), Positives = 134/313 (42%), Gaps = 58/313 (18%)

Query: 480 GEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHA-------------NALFDYAVTGDV 526
           G V L +A G   E A     L LE    + +  A             NAL   A  G +
Sbjct: 48  GRVALHWAAGAGHEQAV---RLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHL 104

Query: 527 KMLLAVQRHLTAVQDENGD--SVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQ 584
           ++L  +      +  E+ D  ++LH A    H  ++  ++E    +  D +    + L +
Sbjct: 105 RILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHV----DKLGR 160

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           T  H A    Q D ++ L+ +G D ++ D+ GN+ LHLAA  GH  VL  L+      L 
Sbjct: 161 TAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLV---DIGLD 217

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKS------------------- 685
           L+  N +GL A+H A   +   C+ LL+ AG+ VNA  QK+                   
Sbjct: 218 LEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVL 277

Query: 686 -------------GRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGS 732
                        G + LHLAV H+  +L   LL+  D+ V++      TPLH+AA    
Sbjct: 278 IHAGGCANVVDHQGASPLHLAVRHNFPALVR-LLINSDSDVNAVDNRQQTPLHLAAEHAW 336

Query: 733 TRLAALLKAAGAD 745
             +A +L  AG D
Sbjct: 337 QDIADMLLIAGVD 349



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 75/259 (28%), Positives = 120/259 (46%), Gaps = 16/259 (6%)

Query: 491 KEESAGVQDNLF-LEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLH 549
           +EE A   D L  LE+ +  A R  N        G ++ L+  +R  T  ++  G   LH
Sbjct: 2   QEELAWETDGLLPLERQLHEAARQNNV-------GRMQELIG-RRVNTRARNHVGRVALH 53

Query: 550 LAIIHLHSQLVRDLLEVTSGLISDDIINMRND----LYQTPLHLAVITKQEDVVEDLLRA 605
            A    H Q VR LLE  + +  +D +    +         L L+       +++ L+ +
Sbjct: 54  WAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNS 113

Query: 606 GADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSL 665
           GA +    + G ++LH AA++GH  VL+ +++  +  + LDH +  G  A H A     L
Sbjct: 114 GAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLE-DVALDHVDKLGRTAFHRAAEHGQL 172

Query: 666 PCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLH 725
             L  LV +G D N ++ K G TALHLA    ++++   L+  G   ++    +G T LH
Sbjct: 173 DALDFLVGSGCDHNVKD-KEGNTALHLAAGRGHMAVLQRLVDIG-LDLEEQNAEGLTALH 230

Query: 726 IAAGRGSTRLAALLKAAGA 744
            AAG        LL  AG+
Sbjct: 231 SAAGGSHPDCVQLLLRAGS 249



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 44/131 (33%), Positives = 69/131 (52%), Gaps = 8/131 (6%)

Query: 509 LAKRHANALFDYAVTG--DVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEV 566
           L +++ + L   A++G  DV  +L        V D  G S LHLA+ H    LVR L+  
Sbjct: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLIN- 312

Query: 567 TSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKE 626
                SD  +N  ++  QTPLHLA     +D+ + LL AG DL+L D+ G + L +A + 
Sbjct: 313 -----SDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRS 367

Query: 627 GHDKVLSILLK 637
            H  ++ +++K
Sbjct: 368 NHVSLVDMIIK 378



 Score = 63.5 bits (153), Expect = 9e-10
 Identities = 53/200 (26%), Positives = 90/200 (45%), Gaps = 41/200 (20%)

Query: 539 VQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDV 598
           V+D+ G++ LHLA    H  +++ L+++   L   +   +      T LH A      D 
Sbjct: 187 VKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGL------TALHSAAGGSHPDC 240

Query: 599 VEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHL 658
           V+ LLRAG+ ++ L +   S LH AA  G + V  +L+     A ++DH    G + +HL
Sbjct: 241 VQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDH---QGASPLHL 297

Query: 659 AMMSNSLPCLLLLVAAGADVNAQEQ--------------------------------KSG 686
           A+  N    + LL+ + +DVNA +                                 K G
Sbjct: 298 AVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357

Query: 687 RTALHLAVEHDNISLAGCLL 706
           +TAL +AV  +++SL   ++
Sbjct: 358 KTALAVAVRSNHVSLVDMII 377



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 56/209 (26%), Positives = 80/209 (38%), Gaps = 42/209 (20%)

Query: 587 LHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKA----- 641
           LH A        +++L+    +    + +G   LH AA  GH++ + +LL+H+ A     
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 642 ---------------ALLLDHPNG--------------------DGLNAIHLAMMSNSLP 666
                          ALLL    G                    DGL  +H A     +P
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138

Query: 667 CLLLLVAAGADVNAQE-QKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLH 725
            L  ++    DV      K GRTA H A EH  +     L+  G  H +    +G T LH
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDH-NVKDKEGNTALH 197

Query: 726 IAAGRGSTRLAALLKAAGADPLVENFEPL 754
           +AAGRG   +   L   G D   +N E L
Sbjct: 198 LAAGRGHMAVLQRLVDIGLDLEEQNAEGL 226


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 64/205 (31%), Positives = 105/205 (51%), Gaps = 11/205 (5%)

Query: 541  DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
            D  G +VL +A    + ++VR LL+   GL      N R+D   TPLH+A       + E
Sbjct: 811  DSEGRTVLSIASAQGNVEVVRTLLD--RGLDE----NHRDDAGWTPLHMAAFEGHRLICE 864

Query: 601  DLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAM 660
             L+  GA  + +D  G     LA++EGH   + ILL++K     +D    DG NA+ +A 
Sbjct: 865  ALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSN---IDQRGYDGRNALRVAA 921

Query: 661  MSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDG 720
            +      + LL + GADVN ++   GR  L++    + +++A    LE  A+V+++  +G
Sbjct: 922  LEGHRDIVELLFSHGADVNCKD-ADGRPTLYILALENQLTMAE-YFLENGANVEASDAEG 979

Query: 721  TTPLHIAAGRGSTRLAALLKAAGAD 745
             T LH++  +G   +  +L A  AD
Sbjct: 980  RTALHVSCWQGHMEMVQVLIAYHAD 1004



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 71/257 (27%), Positives = 115/257 (44%), Gaps = 37/257 (14%)

Query: 520 YAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLL--------------- 564
           Y+ + DV  LL  +     ++D +G + L LA    H+++V  L+               
Sbjct: 554 YSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWT 613

Query: 565 -----------EVTSGLISDDI-INMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLL 612
                      EV S L+   + ++  +   +T L  A     ED+V +LL+ GA+++  
Sbjct: 614 ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673

Query: 613 DRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM-----SNSLPC 667
           D  G + L  AA  GH +++  LL H      ++H + DG  A+ +A +           
Sbjct: 674 DNEGRTALIAAAYMGHREIVEHLLDHGAE---VNHEDVDGRTALSVAALCVPASKGHASV 730

Query: 668 LLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIA 727
           + LL+  GA+V+  + K G T L +A    ++ +   LLLEG A VD T  +G TPL  A
Sbjct: 731 VSLLIDRGAEVDHCD-KDGMTPLLVAAYEGHVDVVD-LLLEGGADVDHTDNNGRTPLLAA 788

Query: 728 AGRGSTRLAALLKAAGA 744
           A  G   +   L   GA
Sbjct: 789 ASMGHASVVNTLLFWGA 805



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 60/210 (28%), Positives = 99/210 (47%), Gaps = 16/210 (7%)

Query: 541 DENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVE 600
           D +  + L  A    H  +V +LL+  +       +N  ++  +T L  A      ++VE
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAE------VNKADNEGRTALIAAAYMGHREIVE 694

Query: 601 DLLRAGADLSLLDRLGNSVLHLAA-----KEGHDKVLSILLKHKKAALLLDHPNGDGLNA 655
            LL  GA+++  D  G + L +AA      +GH  V+S+L+        +DH + DG+  
Sbjct: 695 HLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE---VDHCDKDGMTP 751

Query: 656 IHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDS 715
           + +A     +  + LL+  GADV+  +  +GRT L  A    + S+   LL  G A VDS
Sbjct: 752 LLVAAYEGHVDVVDLLLEGGADVDHTDN-NGRTPLLAAASMGHASVVNTLLFWGAA-VDS 809

Query: 716 TTYDGTTPLHIAAGRGSTRLAALLKAAGAD 745
              +G T L IA+ +G+  +   L   G D
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 60/195 (30%), Positives = 92/195 (47%), Gaps = 13/195 (6%)

Query: 557 SQLVRDLLE----VTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLL 612
           S +VR  LE    + + L +   +N  +   +T L  A  +   DVV  L+  GADL + 
Sbjct: 515 SCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIE 574

Query: 613 DRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLV 672
           D  G++ L LAA++GH KV++ L+        ++H + DG  A+  A        +  L+
Sbjct: 575 DAHGHTPLTLAARQGHTKVVNCLI---GCGANINHTDQDGWTALRSAAWGGHTEVVSALL 631

Query: 673 AAGADVNAQEQKSGRTALHLAV--EHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGR 730
            AG  V+  +  S RTAL  A    H++I L    LL+  A V+    +G T L  AA  
Sbjct: 632 YAGVKVDCADADS-RTALRAAAWGGHEDIVLN---LLQHGAEVNKADNEGRTALIAAAYM 687

Query: 731 GSTRLAALLKAAGAD 745
           G   +   L   GA+
Sbjct: 688 GHREIVEHLLDHGAE 702



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 57/193 (29%), Positives = 83/193 (43%), Gaps = 36/193 (18%)

Query: 585 TPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALL 644
           TPL +A      DVV+ LL  GAD+   D  G + L  AA  GH  V++ LL    A   
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA--- 806

Query: 645 LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAV---------- 694
           +D  + +G   + +A    ++  +  L+  G D N ++  +G T LH+A           
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD-AGWTPLHMAAFEGHRLICEA 865

Query: 695 ---------EHDN-----ISLAG------C--LLLEGDAHVDSTTYDGTTPLHIAAGRGS 732
                    E DN       LA       C  +LLE  +++D   YDG   L +AA  G 
Sbjct: 866 LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGH 925

Query: 733 TRLAALLKAAGAD 745
             +  LL + GAD
Sbjct: 926 RDIVELLFSHGAD 938



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 50/205 (24%), Positives = 98/205 (47%), Gaps = 11/205 (5%)

Query: 543  NGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDL 602
            +G + L +A +  H    RD++E+     +D  +N ++   +  L++  +  Q  + E  
Sbjct: 912  DGRNALRVAALEGH----RDIVELLFSHGAD--VNCKDADGRPTLYILALENQLTMAEYF 965

Query: 603  LRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMS 662
            L  GA++   D  G + LH++  +GH +++ +L+ +       D+   +  +A+  A   
Sbjct: 966  LENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADN---EKRSALQSAAWQ 1022

Query: 663  NSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTT 722
              +  + LL+  GA V+      G TAL +A +  +I +   +LLE  A  +     G T
Sbjct: 1023 GHVKVVQLLIEHGAVVD-HTCNQGATALCIAAQEGHIDVVQ-VLLEHGADPNHADQFGRT 1080

Query: 723  PLHIAAGRGSTRLAALLKAAGADPL 747
             + +AA  G +++  LL+  GA  L
Sbjct: 1081 AMRVAAKNGHSQIIKLLEKYGASSL 1105



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 54/213 (25%), Positives = 100/213 (46%), Gaps = 15/213 (7%)

Query: 515  NALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRD--LLEVTSGLIS 572
            NAL   A+ G   ++  +  H   V  ++ D    L I+ L +QL      LE  + + +
Sbjct: 915  NALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEA 974

Query: 573  DDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVL 632
             D         +T LH++      ++V+ L+   AD++  D    S L  AA +GH KV+
Sbjct: 975  SDAEG------RTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 1028

Query: 633  SILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHL 692
             +L++H     ++DH    G  A+ +A     +  + +L+  GAD N  +Q  GRTA+ +
Sbjct: 1029 QLLIEH---GAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQ-FGRTAMRV 1084

Query: 693  AVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLH 725
            A ++ +  +   L   G + ++  +    +P+H
Sbjct: 1085 AAKNGHSQIIKLLEKYGASSLNGCS---PSPVH 1114



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 4/83 (4%)

Query: 668 LLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIA 727
           L LLV AGA VN+++ ++           D+I      LL+  A V+    +G T L  A
Sbjct: 497 LQLLVKAGAHVNSEDDRTSCIVRQALEREDSIR----TLLDNGASVNQCDSNGRTLLANA 552

Query: 728 AGRGSTRLAALLKAAGADPLVEN 750
           A  GS  +  LL + GAD  +E+
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIED 575


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,572,526
Number of Sequences: 37866
Number of extensions: 1993575
Number of successful extensions: 20815
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 525
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 9095
Number of HSP's gapped (non-prelim): 5291
length of query: 969
length of database: 18,247,518
effective HSP length: 112
effective length of query: 857
effective length of database: 14,006,526
effective search space: 12003592782
effective search space used: 12003592782
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.