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Search of human proteins with 34577114
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34577114 cytomatrix protein p110 [Homo sapiens]
(957 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34577114 cytomatrix protein p110 [Homo sapiens] 1851 0.0
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 1290 0.0
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 1277 0.0
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 143 9e-34
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 143 9e-34
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 143 9e-34
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 143 9e-34
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 141 3e-33
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 141 3e-33
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 140 7e-33
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 137 6e-32
gi|4506751 restin isoform a [Homo sapiens] 136 8e-32
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 135 1e-31
gi|38044112 restin isoform b [Homo sapiens] 135 2e-31
gi|112420968 coiled-coil domain containing 158 [Homo sapiens] 134 5e-31
gi|71061468 centromere protein E [Homo sapiens] 134 5e-31
gi|156104908 myosin heavy chain 6 [Homo sapiens] 132 2e-30
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 131 3e-30
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 131 3e-30
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 130 8e-30
gi|118498356 kinectin 1 isoform a [Homo sapiens] 127 4e-29
gi|118498368 kinectin 1 isoform c [Homo sapiens] 127 4e-29
gi|33620775 kinectin 1 isoform a [Homo sapiens] 127 4e-29
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 127 4e-29
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 127 5e-29
gi|55770834 centromere protein F [Homo sapiens] 127 5e-29
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 127 6e-29
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 126 8e-29
gi|45439327 periplakin [Homo sapiens] 125 2e-28
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 124 3e-28
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 1851 bits (4795), Expect = 0.0
Identities = 957/957 (100%), Positives = 957/957 (100%)
Query: 1 MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSG 60
MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSG
Sbjct: 1 MYGSARTITNLEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSG 60
Query: 61 PMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQ 120
PMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQ
Sbjct: 61 PMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQ 120
Query: 121 HGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMN 180
HGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMN
Sbjct: 121 HGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMN 180
Query: 181 SIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNH 240
SIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNH
Sbjct: 181 SIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNH 240
Query: 241 LLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNA 300
LLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNA
Sbjct: 241 LLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNA 300
Query: 301 RDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREEL 360
RDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREEL
Sbjct: 301 RDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREEL 360
Query: 361 HRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIK 420
HRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIK
Sbjct: 361 HRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIK 420
Query: 421 QIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 480
QIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA
Sbjct: 421 QIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 480
Query: 481 KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 540
KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK
Sbjct: 481 KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 540
Query: 541 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 600
INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL
Sbjct: 541 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 600
Query: 601 KEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR 660
KEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR
Sbjct: 601 KEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR 660
Query: 661 DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG
Sbjct: 661 DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
Query: 721 KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA 780
KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA
Sbjct: 721 KAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA 780
Query: 781 QLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANL 840
QLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANL
Sbjct: 781 QLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANL 840
Query: 841 RIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQ 900
RIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQ
Sbjct: 841 RIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQ 900
Query: 901 LKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDEEGIWA 957
LKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDEEGIWA
Sbjct: 901 LKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDEEGIWA 957
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 1290 bits (3339), Expect = 0.0
Identities = 690/1003 (68%), Positives = 818/1003 (81%), Gaps = 77/1003 (7%)
Query: 1 MYGSARTITNLEGS---PSRSPRLPRSPRLGHRRTSSGGG-------GGTGKTLSMENIQ 50
MYGSAR++ +E S P RSPRLPRSPRLGHRRT+S GG GG+GKTLSMENIQ
Sbjct: 1 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
Query: 51 SLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLS 110
SLNAAYATSGPMYLSDHE V S T PK TMTLGR+ R YG R+TAMGSSPNIAS+G++
Sbjct: 61 SLNAAYATSGPMYLSDHENVGSET-PKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVA 119
Query: 111 HTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDI 170
+D +++ + H + VP LRQ RD+T++DLQ QLKE+ RENDLLRK++++
Sbjct: 120 -SDTIAFGEHHLPPVSMAS----TVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEV 174
Query: 171 KDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230
K+SKL SSMNSIKTFWSPELKKER LRK+EA+++++ KEQ RV EENQH+Q+TIQALQD
Sbjct: 175 KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
Query: 231 ELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELR 290
ELR QRDLN L QQ+S +R E ELTEENF+RL AEH+RQAKELFLLRKTLEEMELR
Sbjct: 235 ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294
Query: 291 IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKE 350
IETQKQTLNARDESIKKLLEMLQSKGL +K+ E+D+ERTRR+AEAE V HLE +L+QKE
Sbjct: 295 IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE 354
Query: 351 KENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVL 410
KEN LREE+HRR + P+ AKTKALQTVIEMKD+KI+S+ER +RDLE+EIQMLK+NG L
Sbjct: 355 KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL 414
Query: 411 NTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQH 470
+TE+REEE+KQ+EVY+SHSKFMK KI Q+KQELS+K++ELLALQTKLETL+NQ SD KQH
Sbjct: 415 STEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 474
Query: 471 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM 530
IEVLKESLTAKEQRAAILQTEVDALRLRLEEKE+ LNKKTKQ+QD+ EEKGT AGEI D+
Sbjct: 475 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 534
Query: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
KDML+VKERK+NVLQKKIENLQEQLRDK+KQ+++LK+RVKSLQ D++NTDTAL TLEEAL
Sbjct: 535 KDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 594
Query: 591 SEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHA 650
+EKER IERLKEQR+RD+RE+ EEI++++K+ KDLKEKV+ LQ +L+EKE+SL+DLKEHA
Sbjct: 595 AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 654
Query: 651 SSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDK 710
SSLAS+GLK+DS+LK+LEIA+EQKKEEC K+E+QLKKAH ++R +PE +D+I+ L++
Sbjct: 655 SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 714
Query: 711 EASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKH 770
E + Y+DE KAQAEVDRLLEILKEVENEKNDKDKKIAELE R +KDQNKKVANLKH
Sbjct: 715 EITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE----RQVKDQNKKVANLKH 770
Query: 771 NQQLEKKKNAQLLEEVRRREDSMADNSQHL------------------------------ 800
+Q+EKKK+AQ+LEE RRRED++ D+SQ L
Sbjct: 771 KEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREM 830
Query: 801 --------------QIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRK 846
Q+EEL+ A+EK +QEL++ KA+L+STQQSLAEKE HL NLR ERRK
Sbjct: 831 VLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRK 890
Query: 847 QLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQ 906
LEE+LEMKQEALLAAISEKDANIALLELS+S KKKTQEEV ALKREKDRLV QLKQQTQ
Sbjct: 891 HLEEVLEMKQEALLAAISEKDANIALLELSSS-KKKTQEEVAALKREKDRLVQQLKQQTQ 949
Query: 907 NRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQ 949
NRMKLMADNY+DDH H S +NH+PSPDQ
Sbjct: 950 NRMKLMADNYEDDHFKSSH------------SNQTNHKPSPDQ 980
Score = 72.4 bits (176), Expect = 2e-12
Identities = 123/596 (20%), Positives = 244/596 (40%), Gaps = 130/596 (21%)
Query: 157 LQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHE 216
LQ E D LR L+ K++ L I+ ++ +E+ +A + LK+ + V
Sbjct: 492 LQTEVDALRLRLEEKETMLNKKTKQIQ-----DMAEEK---GTQAGEIHDLKDMLDVKER 543
Query: 217 ENQHLQLTIQALQDELRT-QRDLNHL------LQQESGNRGAEHFTIELT----EENFRR 265
+ LQ I+ LQ++LR ++ ++ L LQ ++ N T+E E R
Sbjct: 544 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603
Query: 266 LQAEHDRQAKE----LFLLRKTLEEMELRIETQKQTLNARDESIKKLLE---MLQSKGLP 318
L+ + DR +E + +K L++++ ++ + L+ ++ S+ L E L S GL
Sbjct: 604 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 663
Query: 319 SKS--------LEDDNERTRRMAEAESQVSH---LEVILDQKEKENI-HLREELHR---- 362
S LE E +M E++ + +H LE + + I HL E+ R
Sbjct: 664 KDSRLKTLEIALEQKKEECLKM-ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE 722
Query: 363 RSQLQPEPAKTKALQTVIEM----KDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
S+ Q E + + +E KD KIA LER ++D ++ LK + ++++
Sbjct: 723 SSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV---EKKKS 779
Query: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE-----------TLSNQNSDC 467
+ +E + + QL+ L KK+ + L+ L L+ + S
Sbjct: 780 AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 839
Query: 468 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEI 527
+ ++E L A E+ ++ E+++++ +L + L +K L +L E+ E+
Sbjct: 840 TNAEKQVEELLMAMEK----VKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 895
Query: 528 RDMKD---MLEVKERKINV----LQKKIENLQEQL----RDKDKQLTNLKDRVKS---LQ 573
+MK + + E+ N+ L + QE++ R+KD+ + LK + ++ L
Sbjct: 896 LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLM 955
Query: 574 TDSSNTDTALATLEEALSEK---ERIIERLKEQRERDDRERL------------------ 612
D+ D ++ + K ++II+ L E + + +L
Sbjct: 956 ADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILR 1015
Query: 613 ------------------------------EEIESFRKENKDLKEKVNALQAELTE 638
+E+E ++N +L+E NA+ ++ +
Sbjct: 1016 GLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIAD 1071
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 1277 bits (3305), Expect = 0.0
Identities = 690/1031 (66%), Positives = 819/1031 (79%), Gaps = 105/1031 (10%)
Query: 1 MYGSARTITNLEGS---PSRSPRLPRSPRLGHRRTSSGGG-------GGTGKTLSMENIQ 50
MYGSAR++ +E S P RSPRLPRSPRLGHRRT+S GG GG+GKTLSMENIQ
Sbjct: 1 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
Query: 51 SLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLS 110
SLNAAYATSGPMYLSDHE V S T PK TMTLGR+ R YG R+TAMGSSPNIAS+G++
Sbjct: 61 SLNAAYATSGPMYLSDHENVGSET-PKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVA 119
Query: 111 HTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDI 170
+D +++ + H + VP LRQ RD+T++DLQ QLKE+ RENDLLRK++++
Sbjct: 120 -SDTIAFGEHHLPPVSMAS----TVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEV 174
Query: 171 KDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230
K+SKL SSMNSIKTFWSPELKKER LRK+EA+++++ KEQ RV EENQH+Q+TIQALQD
Sbjct: 175 KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
Query: 231 ELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELR 290
ELR QRDLN L QQ+S +R E ELTEENF+RL AEH+RQAKELFLLRKTLEEMELR
Sbjct: 235 ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294
Query: 291 IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKE 350
IETQKQTLNARDESIKKLLEMLQSKGL +K+ E+D+ERTRR+AEAE V HLE +L+QKE
Sbjct: 295 IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE 354
Query: 351 KENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVL 410
KEN LREE+HRR + P+ AKTKALQTVIEMKD+KI+S+ER +RDLE+EIQMLK+NG L
Sbjct: 355 KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL 414
Query: 411 NTEDREEEIKQIEVYKSHSKFMKTKIDQL----------------------------KQE 442
+TE+REEE+KQ+EVY+SHSKFMK K++QL KQE
Sbjct: 415 STEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQE 474
Query: 443 LSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 502
LS+K++ELLALQTKLETL+NQ SD KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK
Sbjct: 475 LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 534
Query: 503 ESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQL 562
E+ LNKKTKQ+QD+ EEKGT AGEI D+KDML+VKERK+NVLQKKIENLQEQLRDK+KQ+
Sbjct: 535 ETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 594
Query: 563 TNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKEN 622
++LK+RVKSLQ D++NTDTAL TLEEAL+EKER IERLKEQR+RD+RE+ EEI++++K+
Sbjct: 595 SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDL 654
Query: 623 KDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLE 682
KDLKEKV+ LQ +L+EKE+SL+DLKEHASSLAS+GLK+DS+LK+LEIA+EQKKEEC K+E
Sbjct: 655 KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME 714
Query: 683 AQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKND 742
+QLKKAH ++R +PE +D+I+ L++E + Y+DE KAQAEVDRLLEILKEVENEKND
Sbjct: 715 SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 774
Query: 743 KDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHL-- 800
KDKKIAELE R +KDQNKKVANLKH +Q+EKKK+AQ+LEE RRRED++ D+SQ L
Sbjct: 775 KDKKIAELE----RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 830
Query: 801 ------------------------------------------QIEELMNALEKTRQELDA 818
Q+EEL+ A+EK +QEL++
Sbjct: 831 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELES 890
Query: 819 TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSAS 878
KA+L+STQQSLAEKE HL NLR ERRK LEE+LEMKQEALLAAISEKDANIALLELS+S
Sbjct: 891 MKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSS 950
Query: 879 KKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRS 938
KKKTQEEV ALKREKDRLV QLKQQTQNRMKLMADNY+DDH H S
Sbjct: 951 -KKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSH------------S 997
Query: 939 QHSNHRPSPDQ 949
+NH+PSPDQ
Sbjct: 998 NQTNHKPSPDQ 1008
Score = 72.4 bits (176), Expect = 2e-12
Identities = 123/596 (20%), Positives = 244/596 (40%), Gaps = 130/596 (21%)
Query: 157 LQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHE 216
LQ E D LR L+ K++ L I+ ++ +E+ +A + LK+ + V
Sbjct: 520 LQTEVDALRLRLEEKETMLNKKTKQIQ-----DMAEEK---GTQAGEIHDLKDMLDVKER 571
Query: 217 ENQHLQLTIQALQDELRT-QRDLNHL------LQQESGNRGAEHFTIELT----EENFRR 265
+ LQ I+ LQ++LR ++ ++ L LQ ++ N T+E E R
Sbjct: 572 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 631
Query: 266 LQAEHDRQAKE----LFLLRKTLEEMELRIETQKQTLNARDESIKKLLE---MLQSKGLP 318
L+ + DR +E + +K L++++ ++ + L+ ++ S+ L E L S GL
Sbjct: 632 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 691
Query: 319 SKS--------LEDDNERTRRMAEAESQVSH---LEVILDQKEKENI-HLREELHR---- 362
S LE E +M E++ + +H LE + + I HL E+ R
Sbjct: 692 KDSRLKTLEIALEQKKEECLKM-ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDE 750
Query: 363 RSQLQPEPAKTKALQTVIEM----KDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
S+ Q E + + +E KD KIA LER ++D ++ LK + ++++
Sbjct: 751 SSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV---EKKKS 807
Query: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE-----------TLSNQNSDC 467
+ +E + + QL+ L KK+ + L+ L L+ + S
Sbjct: 808 AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 867
Query: 468 KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEI 527
+ ++E L A E+ ++ E+++++ +L + L +K L +L E+ E+
Sbjct: 868 TNAEKQVEELLMAMEK----VKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 923
Query: 528 RDMKD---MLEVKERKINV----LQKKIENLQEQL----RDKDKQLTNLKDRVKS---LQ 573
+MK + + E+ N+ L + QE++ R+KD+ + LK + ++ L
Sbjct: 924 LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLM 983
Query: 574 TDSSNTDTALATLEEALSEK---ERIIERLKEQRERDDRERL------------------ 612
D+ D ++ + K ++II+ L E + + +L
Sbjct: 984 ADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILR 1043
Query: 613 ------------------------------EEIESFRKENKDLKEKVNALQAELTE 638
+E+E ++N +L+E NA+ ++ +
Sbjct: 1044 GLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIAD 1099
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 143 bits (360), Expect = 9e-34
Identities = 203/848 (23%), Positives = 370/848 (43%), Gaps = 138/848 (16%)
Query: 134 QVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKE 193
Q S L + ++ LQA+ EL E + +R L K +L ++ ++ E +
Sbjct: 880 QKHSQLTEEKNLLQEQLQAET-ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938
Query: 194 RVL---RKEEAARMSVLKEQMRVSHEENQHLQLT-------IQALQDELRTQRDLNHLLQ 243
+ L RK+ A +M L+EQ+ Q LQL I+ L+DE+ D N+ L
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 244 QESGNRGAEHFTIELTEENFRRLQ---AEHDRQAKELFLLRKTLEEMELRIETQKQTLNA 300
+E +L EE L AE + +AK L L+ E M +E + +
Sbjct: 999 KER----------KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK---- 1044
Query: 301 RDESIKKLLEMLQSKGLPSKSLEDD-NERTRRMAEAESQVSHLEVILDQKEKENIHLREE 359
++E ++ LE L+ K LE D ++ ++A+ ++Q++ L++ L +KE+E L+
Sbjct: 1045 KEEKSRQELEKLKRK------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAA 1095
Query: 360 LHRRSQLQPEPA-KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
L R L E A K AL+ KI LE +I DL++++ +A
Sbjct: 1096 LAR---LDDEIAQKNNALK--------KIRELEGHISDLQEDLDSERA------------ 1132
Query: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESL 478
+ +K K K D L +EL ++EL T + +Q + VLK++L
Sbjct: 1133 --------ARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 479 -----TAKEQRAAILQTEVDALRLRLEEKESFLNKKT---KQLQDLTEEKGTLAGEIRDM 530
+ + Q + Q A+ E+ E F K K Q L +E LAGE+R +
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
+ E K L+ +++ LQ + D ++ L D+V LQ + + L E
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 591 SEKERIIERLKEQRERDDRERLEEIESFRKEN-----KDLKEKVNALQAELTEKESSLID 645
+ + + L Q + D +E L+E E+ +K N + L+E+ N+LQ +L E+ + +
Sbjct: 1304 IKLAKDVASLSSQLQ-DTQELLQE-ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI 705
L+ H S+L KL+ +E +E + + + IE+ ++ E A
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE------IENLTQQYEEKAAAY 1415
Query: 706 KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKV 765
+L+K + + E ++D +++ +E ++ D+ +AE ++++ ++ ++++
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 766 ANLKH------------NQQLEKKKNAQL--------LEEVRRREDSMADNSQHL----- 800
A + + LE K+ + +E++ +D + N L
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 801 ----QIEELMNALEKTRQELDAT---KARLASTQQSLA---EKEAHLAN-LRIERRKQLE 849
Q+EE+ LE+ EL AT K RL Q+L E++ + E+R+QL+
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 850 EIL---------EMKQEALLAAISEK-DANIALLELSASKKKKTQEEVMALKREKDRLVH 899
L E KQ AL AA +K + ++ LEL A K +EE + R+ +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 900 QLKQQTQN 907
+++ ++
Sbjct: 1656 DFQRELED 1663
Score = 131 bits (330), Expect = 3e-30
Identities = 192/873 (21%), Positives = 371/873 (42%), Gaps = 135/873 (15%)
Query: 124 LTGSSHHHHHQVPSMLRQVRDSTML------DLQAQLK----ELQRENDLLRK--ELDIK 171
L G + H Q+ + Q+ + M +LQA L E+ ++N+ L+K EL+
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Query: 172 DSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE-------QMRVSHEENQHLQLT 224
S L ++S + + K++R L +E A + L++ Q + + Q + +
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 225 IQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTL 284
+AL +E R+ ++Q+ + E T +L E F+R +A D+ ++TL
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHA-QAVEELTEQL--EQFKRAKANLDKN-------KQTL 1229
Query: 285 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTR-----RMAEAESQV 339
E+ + + + L + ++ + L+++ +S D ER R ++ + +++V
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 340 SHLEVILDQKEKENIHLREELHR-RSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398
+ +L++ E + I L +++ SQLQ Q +++ + + ++ +R LE
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDT-------QELLQEETRQKLNVSTKLRQLE 1342
Query: 399 DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE 458
+E L+ + +EE++ + + H + ++ K++L S + AL+ +
Sbjct: 1343 EERNSLQ-------DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE---SFLNKKTKQLQD 515
+ + Q E + E+ LQ E+D L + L+ + S L KK ++
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 516 LTEEKGTLAGEIRDMKDMLEVK-------------------------ERKINVLQKKIEN 550
L E+ ++ + D +D E + ER +L+ ++E+
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI-------IERLKEQ 603
L D K + L+ ++L+T T L LE+ L E ++ LK Q
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 604 RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSK 663
ERD + R E+ E R++ LQ +L E E+ L D ++ + A+A K +
Sbjct: 1576 FERDLQARDEQNEEKRRQ----------LQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 664 LKSLEI----AIEQKKE---ECSKLEAQLKK-AHNIEDDSRMNPEFADQIKQLDKEASYY 715
LK LE+ AI+ ++E + KL+AQ+K +ED E K+ +K+A
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK-- 1683
Query: 716 RDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 775
+A++ +L E L E + D + EL + +N L+ ++
Sbjct: 1684 -----SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA----LQDEKRRL 1734
Query: 776 KKKNAQLLEEVRRREDSMADNSQHL-----QIEELMNAL----------EKTRQELDATK 820
+ + AQL EE+ + +M S + Q E+L N L E RQ+L+
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 821 ARLASTQQSL--AEKEAHLANLRIERRK--QLEEILEMK---QEALLAAISEKDANIALL 873
L S + A K + + K QLEE +E + ++A ++ +KD + +
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 874 ELSASKKKKTQEEVMALKREKDRLVHQLKQQTQ 906
L ++K E+ + + V QLK+Q +
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Score = 120 bits (301), Expect = 6e-27
Identities = 175/783 (22%), Positives = 347/783 (44%), Gaps = 139/783 (17%)
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENF--- 263
+K ++V+ +E + +QA +DEL+ ++ + E +H +LTEE
Sbjct: 841 VKPLLQVTRQEEE-----MQAKEDELQKTKERQQKAENELKELEQKHS--QLTEEKNLLQ 893
Query: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLE 323
+LQAE + A+ EEM +R+ +KQ L +++L ++++ LE
Sbjct: 894 EQLQAETELYAEA--------EEMRVRLAAKKQEL-------EEILHEMEAR------LE 932
Query: 324 DDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
++ +R +++ +++ + +LD +E+ L EE R +LQ E +A
Sbjct: 933 EEEDRGQQLQAERKKMA--QQMLDLEEQ----LEEEEAARQKLQLEKVTAEA-------- 978
Query: 384 DTKIASLERNIRDLEDEIQML-KANGVLNTEDR--EEEIKQIEVYKSHSKFMKTKIDQLK 440
I+ LEDEI ++ N L+ E + EE I + + + + +LK
Sbjct: 979 ---------KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAK----EQRAAILQTEVDALR 496
+K ES + L+ +L+ + +Q +E LK L ++ A LQ ++ L+
Sbjct: 1030 ---NKHESMISELEVRLK----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 497 LRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLR 556
++L +KE L +L D +K +IR++ E I+ LQ+ +++ +
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIREL-------EGHISDLQEDLDSERAARN 1135
Query: 557 DKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIE 616
+KQ +L + +++L+T+ +T + AT +E +++E+ + LK+ + + R +++
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 617 SFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE 676
R+++ + V L +L + + + +L ++ +L +L+ L A ++ +
Sbjct: 1196 EMRQKH---AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 677 ECSKLEAQLKKAHN-IEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL----- 730
+ KLEAQ+++ + D R E D++ +L E +A+ + +L
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 731 ---------EILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN---------- 771
E+L+E +K + K+ +LE ++DQ + K N
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNI 1371
Query: 772 QQLEKKKNAQ-------LLEEVRRREDSMADN--SQHLQIEELMNALEKTR----QELD- 817
Q + KK Q LEE ++R +N Q+ + + LEKT+ QELD
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 818 -----ATKARLAST--------QQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAIS 864
+ +L S Q LAE++ + ER + E E + +AL A +
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 865 EKDANIALLELSASKK--KKTQEEVMALKREKDRLVHQLKQ-----QTQ-NRMKLMADNY 916
++A A EL + K K E++++ K + + VH+L++ +TQ MK +
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 917 DDD 919
+D+
Sbjct: 1552 EDE 1554
Score = 117 bits (293), Expect = 5e-26
Identities = 164/735 (22%), Positives = 328/735 (44%), Gaps = 104/735 (14%)
Query: 150 LQAQLKELQR---ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSV 206
L+AQ++ELQ + + R EL+ K KL + + S+ +L + E + +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL 1306
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
K+ +S + LQ T + LQ+E R + +++ L+Q EE L
Sbjct: 1307 AKDVASLSSQ----LQDTQELLQEETRQKLNVSTKLRQ--------------LEEERNSL 1348
Query: 267 QAEHDRQAKELFLLRKTLEEMELR--IETQKQTLNARDESIKKLLEMLQSKGLPSKSLED 324
Q + D EEME + +E TLN + KK L+ S ++LE+
Sbjct: 1349 QDQLD-------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFAST---VEALEE 1392
Query: 325 DNERTRRMAE-AESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
+R ++ E Q D+ EK L++EL L + + L + +E K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL---DDLVVDLDNQRQLVSNLEKK 1449
Query: 384 DTKIASL---ERNIRD-LEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQL 439
K L E+NI DE +A E RE+E K + + ++ + ++ K
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEA------EAREKETKALSLARALEEALEAK---- 1499
Query: 440 KQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 499
+EL + L A ++E L + D +++ L++S A L+T+++ ++ +L
Sbjct: 1500 -EELERTNKMLKA---EMEDLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQL 1548
Query: 500 EEKESFLNKKTKQLQDLTEEKGTLAGEI-RDMKDMLEVKERKINVLQKKIENLQEQLRDK 558
EE E L L L G+ RD++ E E K LQ+++ + +L D+
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 559 DKQLTNLKDRVKSLQTDSSN----TDTALATLEEALSEKERIIERLKE-QRERDD-RERL 612
KQ K L+ D + D+A+ EEA+ + ++ ++K+ QRE +D R
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668
Query: 613 EEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIE 672
+EI + KEN+ +K +L+A+L + + DL + A L+++ + L ++
Sbjct: 1669 DEIFATAKENE---KKAKSLEADLMQLQE---DLAAAERARKQADLEKEELAEELASSLS 1722
Query: 673 QK---KEECSKLEAQLKKAHNIEDDSRMNPE-FADQIKQLDKEASYYRDECGKAQAEVDR 728
+ ++E +LEA++ + ++ + N E +D++++ ++A +E ++ +
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 729 LLEILKEVENEKNDKDKKIAELESLTLRHMKDQ----NKKVANLKHNQQLEKKKNAQLLE 784
+++E + + K+ E+E K K+A L+ + E ++ +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 785 EVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSL--AEKEAHLANL-R 841
+++++ + + LQ+E+ E+ +++ + AR+ ++ L AE+E+ N R
Sbjct: 1843 SLKQKDKKLKEIL--LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 842 IERRKQLEEILEMKQ 856
+ +++L+E E +
Sbjct: 1901 RKLQRELDEATESNE 1915
Score = 83.2 bits (204), Expect = 1e-15
Identities = 114/528 (21%), Positives = 233/528 (44%), Gaps = 81/528 (15%)
Query: 117 YTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKEL-DIKDSK- 174
Y D+ + + S+ R + ++ L+A+ +EL+R N +L+ E+ D+ SK
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEA----LEAK-EELERTNKMLKAEMEDLVSSKD 1521
Query: 175 -LGSSMNSIKTFWSPELKKERVLR---KEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230
+G +++ ++ K +R L +E ++ L+++++ + + L++ +QAL+
Sbjct: 1522 DVGKNVHELE-------KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 231 ELRTQ---RDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM 287
+ RD + ++ R + EL +E +R A ++ L L+++
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK-----LEGDLKDL 1629
Query: 288 ELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD----NERTRRMAEAESQVSHLE 343
EL+ ++ + R+E+IK+L ++ + LED +E E E + LE
Sbjct: 1630 ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Query: 344 VILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLE-RNIRDLEDEIQ 402
L Q + E++ E +++ L+ E E+ + +SL RN L+DE +
Sbjct: 1687 ADLMQLQ-EDLAAAERARKQADLEKE-----------ELAEELASSLSGRNA--LQDEKR 1732
Query: 403 MLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSN 462
L+A E+ EEE +E + + +QL EL+ + S ++ + L
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 463 QNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGT 522
QN + + + ++ ++ +K ++ + AL ++ + E + ++ ++ Q T+
Sbjct: 1793 QNKELRSKLHEMEGAVKSK------FKSTIAALEAKIAQLEEQVEQEAREKQAATKS--- 1843
Query: 523 LAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTA 582
L+ K++K+ + ++E+ ++ +Q RVK L+
Sbjct: 1844 -----------LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ------- 1885
Query: 583 LATLEEALSEKERI-IERLKEQRERDDRERLEEIESFRKENKDLKEKV 629
LEEA E +RI R K QRE D E E E+ +E LK K+
Sbjct: 1886 ---LEEAEEESQRINANRRKLQRELD--EATESNEAMGREVNALKSKL 1928
Score = 31.6 bits (70), Expect = 3.7
Identities = 33/149 (22%), Positives = 61/149 (40%), Gaps = 37/149 (24%)
Query: 133 HQVPSMLRQVRDSTMLDLQAQLKELQ-------RENDLLRKELDIKDSKLGSSMNSIKTF 185
H++ ++ ST+ L+A++ +L+ RE K L KD KL + ++
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE-- 1859
Query: 186 WSPELKKERVLRKEEA----ARMSVLKEQMRVSHEENQHLQLT----------------- 224
+ +K KE+A AR+ LK Q+ + EE+Q +
Sbjct: 1860 ---DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Query: 225 ----IQALQDELRTQRDLNHLLQQESGNR 249
+ AL+ +LR + + + + SG R
Sbjct: 1917 MGREVNALKSKLRRGNETSFVPSRRSGGR 1945
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 143 bits (360), Expect = 9e-34
Identities = 203/848 (23%), Positives = 370/848 (43%), Gaps = 138/848 (16%)
Query: 134 QVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKE 193
Q S L + ++ LQA+ EL E + +R L K +L ++ ++ E +
Sbjct: 887 QKHSQLTEEKNLLQEQLQAET-ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945
Query: 194 RVL---RKEEAARMSVLKEQMRVSHEENQHLQLT-------IQALQDELRTQRDLNHLLQ 243
+ L RK+ A +M L+EQ+ Q LQL I+ L+DE+ D N+ L
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 244 QESGNRGAEHFTIELTEENFRRLQ---AEHDRQAKELFLLRKTLEEMELRIETQKQTLNA 300
+E +L EE L AE + +AK L L+ E M +E + +
Sbjct: 1006 KER----------KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK---- 1051
Query: 301 RDESIKKLLEMLQSKGLPSKSLEDD-NERTRRMAEAESQVSHLEVILDQKEKENIHLREE 359
++E ++ LE L+ K LE D ++ ++A+ ++Q++ L++ L +KE+E L+
Sbjct: 1052 KEEKSRQELEKLKRK------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAA 1102
Query: 360 LHRRSQLQPEPA-KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
L R L E A K AL+ KI LE +I DL++++ +A
Sbjct: 1103 LAR---LDDEIAQKNNALK--------KIRELEGHISDLQEDLDSERA------------ 1139
Query: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESL 478
+ +K K K D L +EL ++EL T + +Q + VLK++L
Sbjct: 1140 --------ARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 479 -----TAKEQRAAILQTEVDALRLRLEEKESFLNKKT---KQLQDLTEEKGTLAGEIRDM 530
+ + Q + Q A+ E+ E F K K Q L +E LAGE+R +
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
+ E K L+ +++ LQ + D ++ L D+V LQ + + L E
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 591 SEKERIIERLKEQRERDDRERLEEIESFRKEN-----KDLKEKVNALQAELTEKESSLID 645
+ + + L Q + D +E L+E E+ +K N + L+E+ N+LQ +L E+ + +
Sbjct: 1311 IKLAKDVASLSSQLQ-DTQELLQE-ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI 705
L+ H S+L KL+ +E +E + + + IE+ ++ E A
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE------IENLTQQYEEKAAAY 1422
Query: 706 KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKV 765
+L+K + + E ++D +++ +E ++ D+ +AE ++++ ++ ++++
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 766 ANLKH------------NQQLEKKKNAQL--------LEEVRRREDSMADNSQHL----- 800
A + + LE K+ + +E++ +D + N L
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 801 ----QIEELMNALEKTRQELDAT---KARLASTQQSLA---EKEAHLAN-LRIERRKQLE 849
Q+EE+ LE+ EL AT K RL Q+L E++ + E+R+QL+
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 850 EIL---------EMKQEALLAAISEK-DANIALLELSASKKKKTQEEVMALKREKDRLVH 899
L E KQ AL AA +K + ++ LEL A K +EE + R+ +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 900 QLKQQTQN 907
+++ ++
Sbjct: 1663 DFQRELED 1670
Score = 131 bits (330), Expect = 3e-30
Identities = 192/873 (21%), Positives = 371/873 (42%), Gaps = 135/873 (15%)
Query: 124 LTGSSHHHHHQVPSMLRQVRDSTML------DLQAQLK----ELQRENDLLRK--ELDIK 171
L G + H Q+ + Q+ + M +LQA L E+ ++N+ L+K EL+
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Query: 172 DSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE-------QMRVSHEENQHLQLT 224
S L ++S + + K++R L +E A + L++ Q + + Q + +
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 225 IQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTL 284
+AL +E R+ ++Q+ + E T +L E F+R +A D+ ++TL
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHA-QAVEELTEQL--EQFKRAKANLDKN-------KQTL 1236
Query: 285 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTR-----RMAEAESQV 339
E+ + + + L + ++ + L+++ +S D ER R ++ + +++V
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 340 SHLEVILDQKEKENIHLREELHR-RSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398
+ +L++ E + I L +++ SQLQ Q +++ + + ++ +R LE
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDT-------QELLQEETRQKLNVSTKLRQLE 1349
Query: 399 DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE 458
+E L+ + +EE++ + + H + ++ K++L S + AL+ +
Sbjct: 1350 EERNSLQ-------DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE---SFLNKKTKQLQD 515
+ + Q E + E+ LQ E+D L + L+ + S L KK ++
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 516 LTEEKGTLAGEIRDMKDMLEVK-------------------------ERKINVLQKKIEN 550
L E+ ++ + D +D E + ER +L+ ++E+
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI-------IERLKEQ 603
L D K + L+ ++L+T T L LE+ L E ++ LK Q
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 604 RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSK 663
ERD + R E+ E R++ LQ +L E E+ L D ++ + A+A K +
Sbjct: 1583 FERDLQARDEQNEEKRRQ----------LQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 664 LKSLEI----AIEQKKE---ECSKLEAQLKK-AHNIEDDSRMNPEFADQIKQLDKEASYY 715
LK LE+ AI+ ++E + KL+AQ+K +ED E K+ +K+A
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK-- 1690
Query: 716 RDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 775
+A++ +L E L E + D + EL + +N L+ ++
Sbjct: 1691 -----SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA----LQDEKRRL 1741
Query: 776 KKKNAQLLEEVRRREDSMADNSQHL-----QIEELMNAL----------EKTRQELDATK 820
+ + AQL EE+ + +M S + Q E+L N L E RQ+L+
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 821 ARLASTQQSL--AEKEAHLANLRIERRK--QLEEILEMK---QEALLAAISEKDANIALL 873
L S + A K + + K QLEE +E + ++A ++ +KD + +
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 874 ELSASKKKKTQEEVMALKREKDRLVHQLKQQTQ 906
L ++K E+ + + V QLK+Q +
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Score = 120 bits (301), Expect = 6e-27
Identities = 175/783 (22%), Positives = 347/783 (44%), Gaps = 139/783 (17%)
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENF--- 263
+K ++V+ +E + +QA +DEL+ ++ + E +H +LTEE
Sbjct: 848 VKPLLQVTRQEEE-----MQAKEDELQKTKERQQKAENELKELEQKHS--QLTEEKNLLQ 900
Query: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLE 323
+LQAE + A+ EEM +R+ +KQ L +++L ++++ LE
Sbjct: 901 EQLQAETELYAEA--------EEMRVRLAAKKQEL-------EEILHEMEAR------LE 939
Query: 324 DDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
++ +R +++ +++ + +LD +E+ L EE R +LQ E +A
Sbjct: 940 EEEDRGQQLQAERKKMA--QQMLDLEEQ----LEEEEAARQKLQLEKVTAEA-------- 985
Query: 384 DTKIASLERNIRDLEDEIQML-KANGVLNTEDR--EEEIKQIEVYKSHSKFMKTKIDQLK 440
I+ LEDEI ++ N L+ E + EE I + + + + +LK
Sbjct: 986 ---------KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAK----EQRAAILQTEVDALR 496
+K ES + L+ +L+ + +Q +E LK L ++ A LQ ++ L+
Sbjct: 1037 ---NKHESMISELEVRLK----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 497 LRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLR 556
++L +KE L +L D +K +IR++ E I+ LQ+ +++ +
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIREL-------EGHISDLQEDLDSERAARN 1142
Query: 557 DKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIE 616
+KQ +L + +++L+T+ +T + AT +E +++E+ + LK+ + + R +++
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 617 SFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE 676
R+++ + V L +L + + + +L ++ +L +L+ L A ++ +
Sbjct: 1203 EMRQKH---AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 677 ECSKLEAQLKKAHN-IEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL----- 730
+ KLEAQ+++ + D R E D++ +L E +A+ + +L
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 731 ---------EILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN---------- 771
E+L+E +K + K+ +LE ++DQ + K N
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNI 1378
Query: 772 QQLEKKKNAQ-------LLEEVRRREDSMADN--SQHLQIEELMNALEKTR----QELD- 817
Q + KK Q LEE ++R +N Q+ + + LEKT+ QELD
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 818 -----ATKARLAST--------QQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAIS 864
+ +L S Q LAE++ + ER + E E + +AL A +
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 865 EKDANIALLELSASKK--KKTQEEVMALKREKDRLVHQLKQ-----QTQ-NRMKLMADNY 916
++A A EL + K K E++++ K + + VH+L++ +TQ MK +
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 917 DDD 919
+D+
Sbjct: 1559 EDE 1561
Score = 117 bits (293), Expect = 5e-26
Identities = 164/735 (22%), Positives = 328/735 (44%), Gaps = 104/735 (14%)
Query: 150 LQAQLKELQR---ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSV 206
L+AQ++ELQ + + R EL+ K KL + + S+ +L + E + +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL 1313
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
K+ +S + LQ T + LQ+E R + +++ L+Q EE L
Sbjct: 1314 AKDVASLSSQ----LQDTQELLQEETRQKLNVSTKLRQ--------------LEEERNSL 1355
Query: 267 QAEHDRQAKELFLLRKTLEEMELR--IETQKQTLNARDESIKKLLEMLQSKGLPSKSLED 324
Q + D EEME + +E TLN + KK L+ S ++LE+
Sbjct: 1356 QDQLD-------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFAST---VEALEE 1399
Query: 325 DNERTRRMAE-AESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
+R ++ E Q D+ EK L++EL L + + L + +E K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL---DDLVVDLDNQRQLVSNLEKK 1456
Query: 384 DTKIASL---ERNIRD-LEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQL 439
K L E+NI DE +A E RE+E K + + ++ + ++ K
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEA------EAREKETKALSLARALEEALEAK---- 1506
Query: 440 KQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 499
+EL + L A ++E L + D +++ L++S A L+T+++ ++ +L
Sbjct: 1507 -EELERTNKMLKA---EMEDLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQL 1555
Query: 500 EEKESFLNKKTKQLQDLTEEKGTLAGEI-RDMKDMLEVKERKINVLQKKIENLQEQLRDK 558
EE E L L L G+ RD++ E E K LQ+++ + +L D+
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 559 DKQLTNLKDRVKSLQTDSSN----TDTALATLEEALSEKERIIERLKE-QRERDD-RERL 612
KQ K L+ D + D+A+ EEA+ + ++ ++K+ QRE +D R
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675
Query: 613 EEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIE 672
+EI + KEN+ +K +L+A+L + + DL + A L+++ + L ++
Sbjct: 1676 DEIFATAKENE---KKAKSLEADLMQLQE---DLAAAERARKQADLEKEELAEELASSLS 1729
Query: 673 QK---KEECSKLEAQLKKAHNIEDDSRMNPE-FADQIKQLDKEASYYRDECGKAQAEVDR 728
+ ++E +LEA++ + ++ + N E +D++++ ++A +E ++ +
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 729 LLEILKEVENEKNDKDKKIAELESLTLRHMKDQ----NKKVANLKHNQQLEKKKNAQLLE 784
+++E + + K+ E+E K K+A L+ + E ++ +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 785 EVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSL--AEKEAHLANL-R 841
+++++ + + LQ+E+ E+ +++ + AR+ ++ L AE+E+ N R
Sbjct: 1850 SLKQKDKKLKEIL--LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 842 IERRKQLEEILEMKQ 856
+ +++L+E E +
Sbjct: 1908 RKLQRELDEATESNE 1922
Score = 83.2 bits (204), Expect = 1e-15
Identities = 114/528 (21%), Positives = 233/528 (44%), Gaps = 81/528 (15%)
Query: 117 YTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKEL-DIKDSK- 174
Y D+ + + S+ R + ++ L+A+ +EL+R N +L+ E+ D+ SK
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEA----LEAK-EELERTNKMLKAEMEDLVSSKD 1528
Query: 175 -LGSSMNSIKTFWSPELKKERVLR---KEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230
+G +++ ++ K +R L +E ++ L+++++ + + L++ +QAL+
Sbjct: 1529 DVGKNVHELE-------KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 231 ELRTQ---RDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM 287
+ RD + ++ R + EL +E +R A ++ L L+++
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK-----LEGDLKDL 1636
Query: 288 ELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD----NERTRRMAEAESQVSHLE 343
EL+ ++ + R+E+IK+L ++ + LED +E E E + LE
Sbjct: 1637 ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Query: 344 VILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLE-RNIRDLEDEIQ 402
L Q + E++ E +++ L+ E E+ + +SL RN L+DE +
Sbjct: 1694 ADLMQLQ-EDLAAAERARKQADLEKE-----------ELAEELASSLSGRNA--LQDEKR 1739
Query: 403 MLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSN 462
L+A E+ EEE +E + + +QL EL+ + S ++ + L
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 463 QNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGT 522
QN + + + ++ ++ +K ++ + AL ++ + E + ++ ++ Q T+
Sbjct: 1800 QNKELRSKLHEMEGAVKSK------FKSTIAALEAKIAQLEEQVEQEAREKQAATKS--- 1850
Query: 523 LAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTA 582
L+ K++K+ + ++E+ ++ +Q RVK L+
Sbjct: 1851 -----------LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ------- 1892
Query: 583 LATLEEALSEKERI-IERLKEQRERDDRERLEEIESFRKENKDLKEKV 629
LEEA E +RI R K QRE D E E E+ +E LK K+
Sbjct: 1893 ---LEEAEEESQRINANRRKLQRELD--EATESNEAMGREVNALKSKL 1935
Score = 31.6 bits (70), Expect = 3.7
Identities = 33/149 (22%), Positives = 61/149 (40%), Gaps = 37/149 (24%)
Query: 133 HQVPSMLRQVRDSTMLDLQAQLKELQ-------RENDLLRKELDIKDSKLGSSMNSIKTF 185
H++ ++ ST+ L+A++ +L+ RE K L KD KL + ++
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE-- 1866
Query: 186 WSPELKKERVLRKEEA----ARMSVLKEQMRVSHEENQHLQLT----------------- 224
+ +K KE+A AR+ LK Q+ + EE+Q +
Sbjct: 1867 ---DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1923
Query: 225 ----IQALQDELRTQRDLNHLLQQESGNR 249
+ AL+ +LR + + + + SG R
Sbjct: 1924 MGREVNALKSKLRRGNETSFVPSRRSGGR 1952
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 143 bits (360), Expect = 9e-34
Identities = 203/848 (23%), Positives = 370/848 (43%), Gaps = 138/848 (16%)
Query: 134 QVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKE 193
Q S L + ++ LQA+ EL E + +R L K +L ++ ++ E +
Sbjct: 887 QKHSQLTEEKNLLQEQLQAET-ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945
Query: 194 RVL---RKEEAARMSVLKEQMRVSHEENQHLQLT-------IQALQDELRTQRDLNHLLQ 243
+ L RK+ A +M L+EQ+ Q LQL I+ L+DE+ D N+ L
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 244 QESGNRGAEHFTIELTEENFRRLQ---AEHDRQAKELFLLRKTLEEMELRIETQKQTLNA 300
+E +L EE L AE + +AK L L+ E M +E + +
Sbjct: 1006 KER----------KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK---- 1051
Query: 301 RDESIKKLLEMLQSKGLPSKSLEDD-NERTRRMAEAESQVSHLEVILDQKEKENIHLREE 359
++E ++ LE L+ K LE D ++ ++A+ ++Q++ L++ L +KE+E L+
Sbjct: 1052 KEEKSRQELEKLKRK------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAA 1102
Query: 360 LHRRSQLQPEPA-KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
L R L E A K AL+ KI LE +I DL++++ +A
Sbjct: 1103 LAR---LDDEIAQKNNALK--------KIRELEGHISDLQEDLDSERA------------ 1139
Query: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESL 478
+ +K K K D L +EL ++EL T + +Q + VLK++L
Sbjct: 1140 --------ARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 479 -----TAKEQRAAILQTEVDALRLRLEEKESFLNKKT---KQLQDLTEEKGTLAGEIRDM 530
+ + Q + Q A+ E+ E F K K Q L +E LAGE+R +
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
+ E K L+ +++ LQ + D ++ L D+V LQ + + L E
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 591 SEKERIIERLKEQRERDDRERLEEIESFRKEN-----KDLKEKVNALQAELTEKESSLID 645
+ + + L Q + D +E L+E E+ +K N + L+E+ N+LQ +L E+ + +
Sbjct: 1311 IKLAKDVASLSSQLQ-DTQELLQE-ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI 705
L+ H S+L KL+ +E +E + + + IE+ ++ E A
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE------IENLTQQYEEKAAAY 1422
Query: 706 KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKV 765
+L+K + + E ++D +++ +E ++ D+ +AE ++++ ++ ++++
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 766 ANLKH------------NQQLEKKKNAQL--------LEEVRRREDSMADNSQHL----- 800
A + + LE K+ + +E++ +D + N L
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 801 ----QIEELMNALEKTRQELDAT---KARLASTQQSLA---EKEAHLAN-LRIERRKQLE 849
Q+EE+ LE+ EL AT K RL Q+L E++ + E+R+QL+
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 850 EIL---------EMKQEALLAAISEK-DANIALLELSASKKKKTQEEVMALKREKDRLVH 899
L E KQ AL AA +K + ++ LEL A K +EE + R+ +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 900 QLKQQTQN 907
+++ ++
Sbjct: 1663 DFQRELED 1670
Score = 131 bits (330), Expect = 3e-30
Identities = 192/873 (21%), Positives = 371/873 (42%), Gaps = 135/873 (15%)
Query: 124 LTGSSHHHHHQVPSMLRQVRDSTML------DLQAQLK----ELQRENDLLRK--ELDIK 171
L G + H Q+ + Q+ + M +LQA L E+ ++N+ L+K EL+
Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
Query: 172 DSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE-------QMRVSHEENQHLQLT 224
S L ++S + + K++R L +E A + L++ Q + + Q + +
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1186
Query: 225 IQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTL 284
+AL +E R+ ++Q+ + E T +L E F+R +A D+ ++TL
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHA-QAVEELTEQL--EQFKRAKANLDKN-------KQTL 1236
Query: 285 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTR-----RMAEAESQV 339
E+ + + + L + ++ + L+++ +S D ER R ++ + +++V
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 340 SHLEVILDQKEKENIHLREELHR-RSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398
+ +L++ E + I L +++ SQLQ Q +++ + + ++ +R LE
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDT-------QELLQEETRQKLNVSTKLRQLE 1349
Query: 399 DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE 458
+E L+ + +EE++ + + H + ++ K++L S + AL+ +
Sbjct: 1350 EERNSLQ-------DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE---SFLNKKTKQLQD 515
+ + Q E + E+ LQ E+D L + L+ + S L KK ++
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 516 LTEEKGTLAGEIRDMKDMLEVK-------------------------ERKINVLQKKIEN 550
L E+ ++ + D +D E + ER +L+ ++E+
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI-------IERLKEQ 603
L D K + L+ ++L+T T L LE+ L E ++ LK Q
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 604 RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSK 663
ERD + R E+ E R++ LQ +L E E+ L D ++ + A+A K +
Sbjct: 1583 FERDLQARDEQNEEKRRQ----------LQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 664 LKSLEI----AIEQKKE---ECSKLEAQLKK-AHNIEDDSRMNPEFADQIKQLDKEASYY 715
LK LE+ AI+ ++E + KL+AQ+K +ED E K+ +K+A
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK-- 1690
Query: 716 RDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 775
+A++ +L E L E + D + EL + +N L+ ++
Sbjct: 1691 -----SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA----LQDEKRRL 1741
Query: 776 KKKNAQLLEEVRRREDSMADNSQHL-----QIEELMNAL----------EKTRQELDATK 820
+ + AQL EE+ + +M S + Q E+L N L E RQ+L+
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 821 ARLASTQQSL--AEKEAHLANLRIERRK--QLEEILEMK---QEALLAAISEKDANIALL 873
L S + A K + + K QLEE +E + ++A ++ +KD + +
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 874 ELSASKKKKTQEEVMALKREKDRLVHQLKQQTQ 906
L ++K E+ + + V QLK+Q +
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Score = 120 bits (301), Expect = 6e-27
Identities = 175/783 (22%), Positives = 347/783 (44%), Gaps = 139/783 (17%)
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENF--- 263
+K ++V+ +E + +QA +DEL+ ++ + E +H +LTEE
Sbjct: 848 VKPLLQVTRQEEE-----MQAKEDELQKTKERQQKAENELKELEQKHS--QLTEEKNLLQ 900
Query: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLE 323
+LQAE + A+ EEM +R+ +KQ L +++L ++++ LE
Sbjct: 901 EQLQAETELYAEA--------EEMRVRLAAKKQEL-------EEILHEMEAR------LE 939
Query: 324 DDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
++ +R +++ +++ + +LD +E+ L EE R +LQ E +A
Sbjct: 940 EEEDRGQQLQAERKKMA--QQMLDLEEQ----LEEEEAARQKLQLEKVTAEA-------- 985
Query: 384 DTKIASLERNIRDLEDEIQML-KANGVLNTEDR--EEEIKQIEVYKSHSKFMKTKIDQLK 440
I+ LEDEI ++ N L+ E + EE I + + + + +LK
Sbjct: 986 ---------KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAK----EQRAAILQTEVDALR 496
+K ES + L+ +L+ + +Q +E LK L ++ A LQ ++ L+
Sbjct: 1037 ---NKHESMISELEVRLK----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 497 LRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLR 556
++L +KE L +L D +K +IR++ E I+ LQ+ +++ +
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIREL-------EGHISDLQEDLDSERAARN 1142
Query: 557 DKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIE 616
+KQ +L + +++L+T+ +T + AT +E +++E+ + LK+ + + R +++
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 617 SFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE 676
R+++ + V L +L + + + +L ++ +L +L+ L A ++ +
Sbjct: 1203 EMRQKH---AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 677 ECSKLEAQLKKAHN-IEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL----- 730
+ KLEAQ+++ + D R E D++ +L E +A+ + +L
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 731 ---------EILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN---------- 771
E+L+E +K + K+ +LE ++DQ + K N
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNI 1378
Query: 772 QQLEKKKNAQ-------LLEEVRRREDSMADN--SQHLQIEELMNALEKTR----QELD- 817
Q + KK Q LEE ++R +N Q+ + + LEKT+ QELD
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 818 -----ATKARLAST--------QQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAIS 864
+ +L S Q LAE++ + ER + E E + +AL A +
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 865 EKDANIALLELSASKK--KKTQEEVMALKREKDRLVHQLKQ-----QTQ-NRMKLMADNY 916
++A A EL + K K E++++ K + + VH+L++ +TQ MK +
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 917 DDD 919
+D+
Sbjct: 1559 EDE 1561
Score = 117 bits (293), Expect = 5e-26
Identities = 164/735 (22%), Positives = 328/735 (44%), Gaps = 104/735 (14%)
Query: 150 LQAQLKELQR---ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSV 206
L+AQ++ELQ + + R EL+ K KL + + S+ +L + E + +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL 1313
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
K+ +S + LQ T + LQ+E R + +++ L+Q EE L
Sbjct: 1314 AKDVASLSSQ----LQDTQELLQEETRQKLNVSTKLRQ--------------LEEERNSL 1355
Query: 267 QAEHDRQAKELFLLRKTLEEMELR--IETQKQTLNARDESIKKLLEMLQSKGLPSKSLED 324
Q + D EEME + +E TLN + KK L+ S ++LE+
Sbjct: 1356 QDQLD-------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFAST---VEALEE 1399
Query: 325 DNERTRRMAE-AESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
+R ++ E Q D+ EK L++EL L + + L + +E K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL---DDLVVDLDNQRQLVSNLEKK 1456
Query: 384 DTKIASL---ERNIRD-LEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQL 439
K L E+NI DE +A E RE+E K + + ++ + ++ K
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEA------EAREKETKALSLARALEEALEAK---- 1506
Query: 440 KQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 499
+EL + L A ++E L + D +++ L++S A L+T+++ ++ +L
Sbjct: 1507 -EELERTNKMLKA---EMEDLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQL 1555
Query: 500 EEKESFLNKKTKQLQDLTEEKGTLAGEI-RDMKDMLEVKERKINVLQKKIENLQEQLRDK 558
EE E L L L G+ RD++ E E K LQ+++ + +L D+
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Query: 559 DKQLTNLKDRVKSLQTDSSN----TDTALATLEEALSEKERIIERLKE-QRERDD-RERL 612
KQ K L+ D + D+A+ EEA+ + ++ ++K+ QRE +D R
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675
Query: 613 EEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIE 672
+EI + KEN+ +K +L+A+L + + DL + A L+++ + L ++
Sbjct: 1676 DEIFATAKENE---KKAKSLEADLMQLQE---DLAAAERARKQADLEKEELAEELASSLS 1729
Query: 673 QK---KEECSKLEAQLKKAHNIEDDSRMNPE-FADQIKQLDKEASYYRDECGKAQAEVDR 728
+ ++E +LEA++ + ++ + N E +D++++ ++A +E ++ +
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 729 LLEILKEVENEKNDKDKKIAELESLTLRHMKDQ----NKKVANLKHNQQLEKKKNAQLLE 784
+++E + + K+ E+E K K+A L+ + E ++ +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 785 EVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSL--AEKEAHLANL-R 841
+++++ + + LQ+E+ E+ +++ + AR+ ++ L AE+E+ N R
Sbjct: 1850 SLKQKDKKLKEIL--LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Query: 842 IERRKQLEEILEMKQ 856
+ +++L+E E +
Sbjct: 1908 RKLQRELDEATESNE 1922
Score = 83.2 bits (204), Expect = 1e-15
Identities = 114/528 (21%), Positives = 233/528 (44%), Gaps = 81/528 (15%)
Query: 117 YTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKEL-DIKDSK- 174
Y D+ + + S+ R + ++ L+A+ +EL+R N +L+ E+ D+ SK
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEA----LEAK-EELERTNKMLKAEMEDLVSSKD 1528
Query: 175 -LGSSMNSIKTFWSPELKKERVLR---KEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230
+G +++ ++ K +R L +E ++ L+++++ + + L++ +QAL+
Sbjct: 1529 DVGKNVHELE-------KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 231 ELRTQ---RDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM 287
+ RD + ++ R + EL +E +R A ++ L L+++
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK-----LEGDLKDL 1636
Query: 288 ELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD----NERTRRMAEAESQVSHLE 343
EL+ ++ + R+E+IK+L ++ + LED +E E E + LE
Sbjct: 1637 ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Query: 344 VILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLE-RNIRDLEDEIQ 402
L Q + E++ E +++ L+ E E+ + +SL RN L+DE +
Sbjct: 1694 ADLMQLQ-EDLAAAERARKQADLEKE-----------ELAEELASSLSGRNA--LQDEKR 1739
Query: 403 MLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSN 462
L+A E+ EEE +E + + +QL EL+ + S ++ + L
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 463 QNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGT 522
QN + + + ++ ++ +K ++ + AL ++ + E + ++ ++ Q T+
Sbjct: 1800 QNKELRSKLHEMEGAVKSK------FKSTIAALEAKIAQLEEQVEQEAREKQAATKS--- 1850
Query: 523 LAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTA 582
L+ K++K+ + ++E+ ++ +Q RVK L+
Sbjct: 1851 -----------LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ------- 1892
Query: 583 LATLEEALSEKERI-IERLKEQRERDDRERLEEIESFRKENKDLKEKV 629
LEEA E +RI R K QRE D E E E+ +E LK K+
Sbjct: 1893 ---LEEAEEESQRINANRRKLQRELD--EATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 143 bits (360), Expect = 9e-34
Identities = 203/848 (23%), Positives = 370/848 (43%), Gaps = 138/848 (16%)
Query: 134 QVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKE 193
Q S L + ++ LQA+ EL E + +R L K +L ++ ++ E +
Sbjct: 880 QKHSQLTEEKNLLQEQLQAET-ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938
Query: 194 RVL---RKEEAARMSVLKEQMRVSHEENQHLQLT-------IQALQDELRTQRDLNHLLQ 243
+ L RK+ A +M L+EQ+ Q LQL I+ L+DE+ D N+ L
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 244 QESGNRGAEHFTIELTEENFRRLQ---AEHDRQAKELFLLRKTLEEMELRIETQKQTLNA 300
+E +L EE L AE + +AK L L+ E M +E + +
Sbjct: 999 KER----------KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK---- 1044
Query: 301 RDESIKKLLEMLQSKGLPSKSLEDD-NERTRRMAEAESQVSHLEVILDQKEKENIHLREE 359
++E ++ LE L+ K LE D ++ ++A+ ++Q++ L++ L +KE+E L+
Sbjct: 1045 KEEKSRQELEKLKRK------LEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAA 1095
Query: 360 LHRRSQLQPEPA-KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
L R L E A K AL+ KI LE +I DL++++ +A
Sbjct: 1096 LAR---LDDEIAQKNNALK--------KIRELEGHISDLQEDLDSERA------------ 1132
Query: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESL 478
+ +K K K D L +EL ++EL T + +Q + VLK++L
Sbjct: 1133 --------ARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 479 -----TAKEQRAAILQTEVDALRLRLEEKESFLNKKT---KQLQDLTEEKGTLAGEIRDM 530
+ + Q + Q A+ E+ E F K K Q L +E LAGE+R +
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
+ E K L+ +++ LQ + D ++ L D+V LQ + + L E
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 591 SEKERIIERLKEQRERDDRERLEEIESFRKEN-----KDLKEKVNALQAELTEKESSLID 645
+ + + L Q + D +E L+E E+ +K N + L+E+ N+LQ +L E+ + +
Sbjct: 1304 IKLAKDVASLSSQLQ-DTQELLQE-ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI 705
L+ H S+L KL+ +E +E + + + IE+ ++ E A
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE------IENLTQQYEEKAAAY 1415
Query: 706 KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKV 765
+L+K + + E ++D +++ +E ++ D+ +AE ++++ ++ ++++
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 766 ANLKH------------NQQLEKKKNAQL--------LEEVRRREDSMADNSQHL----- 800
A + + LE K+ + +E++ +D + N L
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 801 ----QIEELMNALEKTRQELDAT---KARLASTQQSLA---EKEAHLAN-LRIERRKQLE 849
Q+EE+ LE+ EL AT K RL Q+L E++ + E+R+QL+
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 850 EIL---------EMKQEALLAAISEK-DANIALLELSASKKKKTQEEVMALKREKDRLVH 899
L E KQ AL AA +K + ++ LEL A K +EE + R+ +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 900 QLKQQTQN 907
+++ ++
Sbjct: 1656 DFQRELED 1663
Score = 131 bits (330), Expect = 3e-30
Identities = 192/873 (21%), Positives = 371/873 (42%), Gaps = 135/873 (15%)
Query: 124 LTGSSHHHHHQVPSMLRQVRDSTML------DLQAQLK----ELQRENDLLRK--ELDIK 171
L G + H Q+ + Q+ + M +LQA L E+ ++N+ L+K EL+
Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
Query: 172 DSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE-------QMRVSHEENQHLQLT 224
S L ++S + + K++R L +E A + L++ Q + + Q + +
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVL 1179
Query: 225 IQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTL 284
+AL +E R+ ++Q+ + E T +L E F+R +A D+ ++TL
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHA-QAVEELTEQL--EQFKRAKANLDKN-------KQTL 1229
Query: 285 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTR-----RMAEAESQV 339
E+ + + + L + ++ + L+++ +S D ER R ++ + +++V
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 340 SHLEVILDQKEKENIHLREELHR-RSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398
+ +L++ E + I L +++ SQLQ Q +++ + + ++ +R LE
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDT-------QELLQEETRQKLNVSTKLRQLE 1342
Query: 399 DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE 458
+E L+ + +EE++ + + H + ++ K++L S + AL+ +
Sbjct: 1343 EERNSLQ-------DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE---SFLNKKTKQLQD 515
+ + Q E + E+ LQ E+D L + L+ + S L KK ++
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 516 LTEEKGTLAGEIRDMKDMLEVK-------------------------ERKINVLQKKIEN 550
L E+ ++ + D +D E + ER +L+ ++E+
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI-------IERLKEQ 603
L D K + L+ ++L+T T L LE+ L E ++ LK Q
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 604 RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSK 663
ERD + R E+ E R++ LQ +L E E+ L D ++ + A+A K +
Sbjct: 1576 FERDLQARDEQNEEKRRQ----------LQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 664 LKSLEI----AIEQKKE---ECSKLEAQLKK-AHNIEDDSRMNPEFADQIKQLDKEASYY 715
LK LE+ AI+ ++E + KL+AQ+K +ED E K+ +K+A
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK-- 1683
Query: 716 RDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLE 775
+A++ +L E L E + D + EL + +N L+ ++
Sbjct: 1684 -----SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA----LQDEKRRL 1734
Query: 776 KKKNAQLLEEVRRREDSMADNSQHL-----QIEELMNAL----------EKTRQELDATK 820
+ + AQL EE+ + +M S + Q E+L N L E RQ+L+
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 821 ARLASTQQSL--AEKEAHLANLRIERRK--QLEEILEMK---QEALLAAISEKDANIALL 873
L S + A K + + K QLEE +E + ++A ++ +KD + +
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 874 ELSASKKKKTQEEVMALKREKDRLVHQLKQQTQ 906
L ++K E+ + + V QLK+Q +
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Score = 120 bits (301), Expect = 6e-27
Identities = 175/783 (22%), Positives = 347/783 (44%), Gaps = 139/783 (17%)
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENF--- 263
+K ++V+ +E + +QA +DEL+ ++ + E +H +LTEE
Sbjct: 841 VKPLLQVTRQEEE-----MQAKEDELQKTKERQQKAENELKELEQKHS--QLTEEKNLLQ 893
Query: 264 RRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLE 323
+LQAE + A+ EEM +R+ +KQ L +++L ++++ LE
Sbjct: 894 EQLQAETELYAEA--------EEMRVRLAAKKQEL-------EEILHEMEAR------LE 932
Query: 324 DDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
++ +R +++ +++ + +LD +E+ L EE R +LQ E +A
Sbjct: 933 EEEDRGQQLQAERKKMA--QQMLDLEEQ----LEEEEAARQKLQLEKVTAEA-------- 978
Query: 384 DTKIASLERNIRDLEDEIQML-KANGVLNTEDR--EEEIKQIEVYKSHSKFMKTKIDQLK 440
I+ LEDEI ++ N L+ E + EE I + + + + +LK
Sbjct: 979 ---------KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAK----EQRAAILQTEVDALR 496
+K ES + L+ +L+ + +Q +E LK L ++ A LQ ++ L+
Sbjct: 1030 ---NKHESMISELEVRLK----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 497 LRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLR 556
++L +KE L +L D +K +IR++ E I+ LQ+ +++ +
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIREL-------EGHISDLQEDLDSERAARN 1135
Query: 557 DKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIE 616
+KQ +L + +++L+T+ +T + AT +E +++E+ + LK+ + + R +++
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 617 SFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE 676
R+++ + V L +L + + + +L ++ +L +L+ L A ++ +
Sbjct: 1196 EMRQKH---AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 677 ECSKLEAQLKKAHN-IEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL----- 730
+ KLEAQ+++ + D R E D++ +L E +A+ + +L
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 731 ---------EILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN---------- 771
E+L+E +K + K+ +LE ++DQ + K N
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNI 1371
Query: 772 QQLEKKKNAQ-------LLEEVRRREDSMADN--SQHLQIEELMNALEKTR----QELD- 817
Q + KK Q LEE ++R +N Q+ + + LEKT+ QELD
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 818 -----ATKARLAST--------QQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAIS 864
+ +L S Q LAE++ + ER + E E + +AL A +
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 865 EKDANIALLELSASKK--KKTQEEVMALKREKDRLVHQLKQ-----QTQ-NRMKLMADNY 916
++A A EL + K K E++++ K + + VH+L++ +TQ MK +
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 917 DDD 919
+D+
Sbjct: 1552 EDE 1554
Score = 117 bits (293), Expect = 5e-26
Identities = 164/735 (22%), Positives = 328/735 (44%), Gaps = 104/735 (14%)
Query: 150 LQAQLKELQR---ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSV 206
L+AQ++ELQ + + R EL+ K KL + + S+ +L + E + +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG----------MLNEAEGKAIKL 1306
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
K+ +S + LQ T + LQ+E R + +++ L+Q EE L
Sbjct: 1307 AKDVASLSSQ----LQDTQELLQEETRQKLNVSTKLRQ--------------LEEERNSL 1348
Query: 267 QAEHDRQAKELFLLRKTLEEMELR--IETQKQTLNARDESIKKLLEMLQSKGLPSKSLED 324
Q + D EEME + +E TLN + KK L+ S ++LE+
Sbjct: 1349 QDQLD-------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFAST---VEALEE 1392
Query: 325 DNERTRRMAE-AESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
+R ++ E Q D+ EK L++EL L + + L + +E K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL---DDLVVDLDNQRQLVSNLEKK 1449
Query: 384 DTKIASL---ERNIRD-LEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQL 439
K L E+NI DE +A E RE+E K + + ++ + ++ K
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEA------EAREKETKALSLARALEEALEAK---- 1499
Query: 440 KQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 499
+EL + L A ++E L + D +++ L++S A L+T+++ ++ +L
Sbjct: 1500 -EELERTNKMLKA---EMEDLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQL 1548
Query: 500 EEKESFLNKKTKQLQDLTEEKGTLAGEI-RDMKDMLEVKERKINVLQKKIENLQEQLRDK 558
EE E L L L G+ RD++ E E K LQ+++ + +L D+
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 559 DKQLTNLKDRVKSLQTDSSN----TDTALATLEEALSEKERIIERLKE-QRERDD-RERL 612
KQ K L+ D + D+A+ EEA+ + ++ ++K+ QRE +D R
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668
Query: 613 EEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIE 672
+EI + KEN+ +K +L+A+L + + DL + A L+++ + L ++
Sbjct: 1669 DEIFATAKENE---KKAKSLEADLMQLQE---DLAAAERARKQADLEKEELAEELASSLS 1722
Query: 673 QK---KEECSKLEAQLKKAHNIEDDSRMNPE-FADQIKQLDKEASYYRDECGKAQAEVDR 728
+ ++E +LEA++ + ++ + N E +D++++ ++A +E ++ +
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 729 LLEILKEVENEKNDKDKKIAELESLTLRHMKDQ----NKKVANLKHNQQLEKKKNAQLLE 784
+++E + + K+ E+E K K+A L+ + E ++ +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 785 EVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSL--AEKEAHLANL-R 841
+++++ + + LQ+E+ E+ +++ + AR+ ++ L AE+E+ N R
Sbjct: 1843 SLKQKDKKLKEIL--LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Query: 842 IERRKQLEEILEMKQ 856
+ +++L+E E +
Sbjct: 1901 RKLQRELDEATESNE 1915
Score = 83.2 bits (204), Expect = 1e-15
Identities = 114/528 (21%), Positives = 233/528 (44%), Gaps = 81/528 (15%)
Query: 117 YTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKEL-DIKDSK- 174
Y D+ + + S+ R + ++ L+A+ +EL+R N +L+ E+ D+ SK
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEA----LEAK-EELERTNKMLKAEMEDLVSSKD 1521
Query: 175 -LGSSMNSIKTFWSPELKKERVLR---KEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230
+G +++ ++ K +R L +E ++ L+++++ + + L++ +QAL+
Sbjct: 1522 DVGKNVHELE-------KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 231 ELRTQ---RDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM 287
+ RD + ++ R + EL +E +R A ++ L L+++
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK-----LEGDLKDL 1629
Query: 288 ELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD----NERTRRMAEAESQVSHLE 343
EL+ ++ + R+E+IK+L ++ + LED +E E E + LE
Sbjct: 1630 ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Query: 344 VILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLE-RNIRDLEDEIQ 402
L Q + E++ E +++ L+ E E+ + +SL RN L+DE +
Sbjct: 1687 ADLMQLQ-EDLAAAERARKQADLEKE-----------ELAEELASSLSGRNA--LQDEKR 1732
Query: 403 MLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSN 462
L+A E+ EEE +E + + +QL EL+ + S ++ + L
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 463 QNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGT 522
QN + + + ++ ++ +K ++ + AL ++ + E + ++ ++ Q T+
Sbjct: 1793 QNKELRSKLHEMEGAVKSK------FKSTIAALEAKIAQLEEQVEQEAREKQAATKS--- 1843
Query: 523 LAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTA 582
L+ K++K+ + ++E+ ++ +Q RVK L+
Sbjct: 1844 -----------LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ------- 1885
Query: 583 LATLEEALSEKERI-IERLKEQRERDDRERLEEIESFRKENKDLKEKV 629
LEEA E +RI R K QRE D E E E+ +E LK K+
Sbjct: 1886 ---LEEAEEESQRINANRRKLQRELD--EATESNEAMGREVNALKSKL 1928
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 141 bits (355), Expect = 3e-33
Identities = 185/830 (22%), Positives = 370/830 (44%), Gaps = 120/830 (14%)
Query: 144 DSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPE---LKKERVLRKE- 199
DST DL Q+ ELQ + L+ +L K+ +L +++ ++ + + LKK R L +
Sbjct: 1056 DST--DLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 200 ---------EAARMSVLKEQMRVSHEENQHLQLTIQ------ALQDELRTQRDLN-HLLQ 243
E A + ++Q R EE + L+ ++ A Q ELR++R+ ++L+
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 244 QESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTL-NARD 302
+ H E + ++ +H + +EL + + ++ +E KQTL N R
Sbjct: 1174 KTLEEEAKTH------EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG 1227
Query: 303 ESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHR 362
E ++ +LQ KG D+E R+ EA Q+ L+V ++ E+ L +++
Sbjct: 1228 ELANEVKVLLQGKG--------DSEHKRKKVEA--QLQELQVKFNEGERVRTELADKV-- 1275
Query: 363 RSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREE----- 417
++LQ E L + D+K + L ++ LE ++Q +L E+R++
Sbjct: 1276 -TKLQVELDNVTGL---LSQSDSKSSKLTKDFSALESQLQ--DTQELLQEENRQKLSLST 1329
Query: 418 EIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKES 477
++KQ+E K+ + +QL++E K + L+ ++ TL Q +D K+ +E
Sbjct: 1330 KLKQVEDEKNSFR------EQLEEEEEAKHN----LEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 478 LTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVK 537
L E+ LQ +++ L R EEK + +K K L +E L ++ +
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439
Query: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALA-TLEEALSEKERI 596
E+K QKK + L + + + +DR ++ + +LA LEEA+ +K +
Sbjct: 1440 EKK----QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Query: 597 IERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASA 656
ERL +Q + + + + K +L++ AL+ ++ E ++ L +L++ + A
Sbjct: 1496 -ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554
Query: 657 GLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYR 716
L+ + L++++ E+ + + +++ KK + M E D+ KQ +
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQGRDE-QSEEKKKQLVRQVREMEAELEDERKQRSMAVA--- 1610
Query: 717 DECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKD-----------QNKKV 765
+ + E+D L ++ +++ ++D+ I +L L + MKD + + +
Sbjct: 1611 ---ARKKLEMD-LKDLEAHIDSANKNRDEAIKQLRKLQAQ-MKDCMRELDDTRASREEIL 1665
Query: 766 ANLKHNQQLEKKKNAQLLE-------------EVRRREDSMADNSQHLQIEELMNALEKT 812
A K N++ K A++++ + ++ D +AD + + + EK
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 813 RQELDATKARLASTQQSLAEKEAHL---------ANLRIERRK---QLEEILEMKQEALL 860
R E AR+A ++ L E++ + ANL+I++ LE K E
Sbjct: 1726 RLE-----ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780
Query: 861 AAI--SEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNR 908
+ K+ + L E+ + K K + + AL+ + +L QL +T+ R
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830
Score = 130 bits (328), Expect = 4e-30
Identities = 172/841 (20%), Positives = 368/841 (43%), Gaps = 89/841 (10%)
Query: 148 LDLQAQLK---ELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAA-- 202
L LQ QL+ EL E + LR L K +L + ++ E ++ + L+ E+
Sbjct: 883 LQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 203 -RMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEE 261
+ L+EQ+ Q LQL + +L+ + +L+ ++ E +E
Sbjct: 943 QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA 1002
Query: 262 NFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKS 321
F E + ++K L L+ E M +E + + + + ++K L+
Sbjct: 1003 EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG------- 1055
Query: 322 LEDDNERTRRMAEAESQVSHLEVILDQKEKE----NIHLREELHRRS----QLQPEPAKT 373
D + + ++AE ++Q++ L++ L +KE+E + EE +++ +++ ++
Sbjct: 1056 --DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 374 KALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTED-----------REEEI--- 419
LQ +E + E+ RDL +E++ LK + +T D RE+E+
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTE-LEDTLDSTAAQQELRSKREQEVNIL 1172
Query: 420 -----KQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE----TLSNQNSDCKQH 470
++ + +++ + M+ K Q +EL+++ + ++ LE TL N+ +
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 471 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM 530
++VL + E + ++ ++ L+++ E E + ++ L E + G +
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292
Query: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
+ + L+ ++++ QE L+++++Q +L ++K ++ + ++ L EEA
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAK 1352
Query: 591 SEKERIIERLKEQ-----RERDDR----ERLEEIESFRKENKDL-------KEKVNA--- 631
E+ I L Q ++ +D E EE++ RK KDL +EKV A
Sbjct: 1353 HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK--RKLQKDLEGLSQRHEEKVAAYDK 1410
Query: 632 -------LQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQ 684
LQ EL + L ++ A +L K D L + + EE + EA+
Sbjct: 1411 LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE 1470
Query: 685 LK-KAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDK 743
+ K +R E +Q +L++ +R E + D + + + E+E K
Sbjct: 1471 AREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 1530
Query: 744 DKKIAELESLTLRHMKD--QNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHL- 800
++++ E+++ L ++D Q + A L+ L+ K AQ +++ R++ + + L
Sbjct: 1531 EQQVEEMKT-QLEELEDELQATEDAKLRLEVNLQAMK-AQFERDLQGRDEQSEEKKKQLV 1588
Query: 801 -QIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEAL 859
Q+ E+ LE R++ A + L + EAH+ + R + ++++ ++ Q +
Sbjct: 1589 RQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL-QAQM 1647
Query: 860 LAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQL------KQQTQNRMKLMA 913
+ E D A E ++ K+ ++++ +++ E +L +L K+Q Q +A
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 914 D 914
D
Sbjct: 1708 D 1708
Score = 125 bits (314), Expect = 2e-28
Identities = 162/727 (22%), Positives = 312/727 (42%), Gaps = 87/727 (11%)
Query: 150 LQAQLKELQ---RENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSV 206
++AQL+ELQ E + +R EL K +KL ++++ S K L K+ S
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD----FSA 1305
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
L+ Q LQ T + LQ+E R + L+ L+Q + + F +L EE
Sbjct: 1306 LESQ----------LQDTQELLQEENRQKLSLSTKLKQVEDEKNS--FREQLEEEE---- 1349
Query: 267 QAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDN 326
+A+H+ + K++ L + +M+ ++E L +E +KL K LE +
Sbjct: 1350 EAKHNLE-KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL----------QKDLEGLS 1398
Query: 327 ERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTK 386
+R A ++ + L Q+E +++ + + R+S E + K Q + E K
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRL-QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457
Query: 387 IASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK 446
E R E RE+E K + + ++ + M+ K + + L+K+
Sbjct: 1458 AKYAEERDR--------------AEAEAREKETKALSLARALEEAMEQKAEL--ERLNKQ 1501
Query: 447 ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 506
+T++E L + D + + L++S A EQ+ ++T+++ L L+ E
Sbjct: 1502 ------FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAK 1555
Query: 507 NKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLK 566
+ LQ + + RD++ E E K L +++ ++ +L D+ KQ +
Sbjct: 1556 LRLEVNLQAMKAQFE------RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 567 DRVKSLQTD----SSNTDTALATLEEALSEKERIIERLKE-QRERDD-RERLEEIESFRK 620
K L+ D ++ D+A +EA+ + ++ ++K+ RE DD R EEI + K
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 621 EN----KDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE 676
EN K ++ ++ LQ EL E + ++ LA K +A+E+K+
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA---LALEEKR- 1725
Query: 677 ECSKLEAQLKKAHNIEDDSRMNPEFA-DQIKQLDKEASYYRDECGKAQAEVDRLLEILKE 735
+LEA++ + ++ + N E D++K+ + + + ++ + ++
Sbjct: 1726 ---RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ 1782
Query: 736 VENEKNDKDKKIAELESLTLRHMKDQ----NKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
+E + + K+ E+E K K+A L+ E K+ ++VRR E
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842
Query: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEI 851
+ D LQ+++ E+ + + D RL ++ L E E RRK E+
Sbjct: 1843 KLKD--VLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 852 LEMKQEA 858
+ + A
Sbjct: 1901 EDATETA 1907
Score = 119 bits (299), Expect = 1e-26
Identities = 151/639 (23%), Positives = 295/639 (46%), Gaps = 65/639 (10%)
Query: 305 IKKLLEML-QSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRR 363
+K LL++ Q + + +K E R +++A AE++++ +E + Q E + L+E+L
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLA-AENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 364 SQLQPEPAKTKALQTVIEMKDTKIA-SLERNIRDLEDEIQMLKANGVLNTEDREEEIKQI 422
++L E + +A T + + +I LE + + E+ Q L+A ++ +E +Q+
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 423 EVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKE 482
E +S + ++ + + +L K E E + L+ + L+ + + I +LT +E
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 483 QRA---AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKER 539
+++ A L+ + +A+ LEE+ L ++ KQ Q+L + + L G+ D+ D
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEER---LRREEKQRQELEKTRRKLEGDSTDLSD------- 1062
Query: 540 KINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIER 599
+I LQ +I L+ QL K+++L RV+ + + LE +SE + +E
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 600 LKEQR---ERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDL---------K 647
+ R E+ R+ EE+E+ + E +D + A Q EL K +++ K
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDS-TAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 648 EHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQ 707
H + + K ++ L +EQ K +++A L+KA ++ R E A+++K
Sbjct: 1182 THEAQIQEMRQKHSQAVEELAEQLEQTK----RVKANLEKAKQTLENER--GELANEVKV 1235
Query: 708 LDKEASYYRDECGKAQAEVDRLLEILKE---VENEKNDKDKKI-AELESLTLRHMKDQNK 763
L + + K +A++ L E V E DK K+ EL+++T + +K
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK 1295
Query: 764 KVANLKHNQQLEK--KKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKA 821
K LE + +LL+E R++ S++ + Q+E+ N+ + +E + K
Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK--QVEDEKNSFREQLEEEEEAKH 1353
Query: 822 RLASTQQSLAEKEAHLANLR---------IERRKQLEEILEMKQEALLAAISEKDANIAL 872
L ++ +A A +A+++ +E ++++ L+ E L EK A
Sbjct: 1354 NL---EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK 1410
Query: 873 LELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKL 911
LE K KT+ L++E D L+ L Q Q+ L
Sbjct: 1411 LE-----KTKTR-----LQQELDDLLVDLDHQRQSACNL 1439
Score = 55.8 bits (133), Expect = 2e-07
Identities = 85/430 (19%), Positives = 174/430 (40%), Gaps = 59/430 (13%)
Query: 113 DVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDL-LRKELDIK 171
D++S D G S H + L Q + L+ ELQ D LR E++++
Sbjct: 1508 DLMSSKDD----VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 172 DSKLGSSMNSIKTFWSPELKKERVLR--KEEAARMSVLKEQMRVSHEENQHLQLTIQALQ 229
K + E KK++++R +E A + ++Q ++ + L++ ++ L+
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 230 DEL---------------RTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQA 274
+ + Q + +++ R + + +EN ++L++
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS----ME 1679
Query: 275 KELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAE 334
E+ L++ L E ++Q RDE E+ S G + +LE+ R+A+
Sbjct: 1680 AEMIQLQEELAAAE---RAKRQAQQERDELAD---EIANSSGKGALALEEKRRLEARIAQ 1733
Query: 335 AESQVS----HLEVILDQKEKENI--------------HLREELHRRSQLQPEPAKTKAL 376
E ++ + E+I D+ +K N+ H ++ + R QL+ + + K
Sbjct: 1734 LEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV- 1792
Query: 377 QTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKI 436
+ EM+ T + + +I LE +I L+ T++R+ KQ+ + K + ++
Sbjct: 1793 -KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851
Query: 437 D-------QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQ 489
D Q K + K + L L+ +LE + L+ L + A +
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Query: 490 TEVDALRLRL 499
EV +L+ +L
Sbjct: 1912 REVSSLKNKL 1921
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 141 bits (355), Expect = 3e-33
Identities = 206/873 (23%), Positives = 392/873 (44%), Gaps = 150/873 (17%)
Query: 129 HHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSP 188
+ H +Q S LRQ + + +A++K++++EN +L + + SKL S F
Sbjct: 560 NEHLNQTVSSLRQ---RSQISAEARVKDIEKENKILHESIKETSSKL-----SKIEFEKR 611
Query: 189 ELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGN 248
++KKE KE+ R L+ ++ +EN+ LQ I L+ + L+QE+
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKI----TNLKITCEKIEALEQENSE 667
Query: 249 RGAEHFTIELTEENFRR-------LQAEHDRQAKELFLLRKTLEEME------LRIETQK 295
E+ ++ T ++F+ L+ E+ + +E LR+ +E ++ +++ +
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 296 QTLNARDESIKKLLEMLQS------------KGLP------SKSLEDDNERTRRM----- 332
+ L + E +KK LE+L++ +GL K+LE+ N++ +++
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 333 -AEAESQV--SHLEVI------LDQKEKENIHLREELHR----RSQLQPEPAKTKALQTV 379
E E+Q +LE + L+Q EKEN L +E + + QL+ E K L+
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE---NKRLRQQ 844
Query: 380 IEMKDT-------KIASLERNIRDLEDEIQMLKANGV----LNTEDRE------EEIKQI 422
E+KDT KI +LE+ + L EI + K + V L E++E +IK +
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 423 EVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETL--SNQNSDCKQHI------EVL 474
+ K K Q+ +L K EL + E L Q++D + + L
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTL 964
Query: 475 KESLTAKEQRAAILQTEVDA-----LRLRLEEKESFLN-KKTKQLQD---LTEEKGTLAG 525
K+SL KE++ A L+ ++ +LR E K N + KQ QD + + ++G
Sbjct: 965 KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1024
Query: 526 E--------IRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSS 577
E +++L+VK+R I V ++ LQ +KQ LK ++K L+T ++
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEV-ERNNATLQ-----AEKQA--LKTQLKQLETQNN 1076
Query: 578 NTDTALATLEE---ALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQA 634
N + L+ +L E+ ++ + + ++ + S +N L + Q+
Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ----QS 1132
Query: 635 ELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAH-NIED 693
L + S+I +E SL + +K KL+ L + E LK AH N+E
Sbjct: 1133 SLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV 1192
Query: 694 DSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESL 753
+ R + D+ QL K+ D LE + +VE EK + K E +
Sbjct: 1193 EHR---DLEDRYNQLLKQKGQLED------------LEKMLKVEQEKMLLENKNHETVAA 1237
Query: 754 TLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNS--QHLQIEELMNALEK 811
+ + +N ++ N ++Q L K ++L+ + S+ +NS + ++E + L++
Sbjct: 1238 EYKKLCGENDRL-NHTYSQLL---KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
Query: 812 TRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIA 871
Q+LD T +L + + L++ + NL E R L++I Q +L + + N+
Sbjct: 1294 QYQQLDITSTKLNNQCELLSQLK---GNLEEENRHLLDQI----QTLMLQNRTLLEQNME 1346
Query: 872 LLELSASKKKKTQEEVMALKREKDRLVHQLKQQ 904
+L ++++ +++ L+R+K++L ++ Q
Sbjct: 1347 SKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
Score = 127 bits (318), Expect = 6e-29
Identities = 205/905 (22%), Positives = 380/905 (41%), Gaps = 159/905 (17%)
Query: 148 LDLQAQLKELQRENDLLRKELD--------IKDSKLGSSMNSIKTFWSPELKKERVLRKE 199
L L+A+L +++ E D+ RK+++ ++ ++ S S+ W E + R
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE-QISRTSELS 443
Query: 200 EAARMSVLKEQMRVSHEENQHLQLTIQALQ---DELRTQRD-----LNHLLQQESGNRGA 251
EA + S+ E ++ L++ Q+L +ELRT D + +L+ E N+
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 252 EHFTIELTEENFRRLQAEHDRQ------AKELFLLRKTLEEMELRIETQKQTLNARDESI 305
L E + Q+ + Q KE L KT+E + E Q + L +E +
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 306 KKLLEMLQSKGLPS-----KSLEDDNERTRR-MAEAESQVSHLEVILDQKEKENIHLREE 359
+ + L+ + S K +E +N+ + E S++S +E Q +KE H +E+
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 360 LHRRSQLQPEPAKTKALQTVIEMKDT-------KIASLERNIRDLEDEIQMLK------A 406
R +L+ E + +++ K T KI +LE+ +LE E + LK
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 407 NGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSD 466
N E E+E Q++ + ++ ++ LK K + LQ + + L ++
Sbjct: 684 NLTFQLESLEKENSQLD---EENLELRRNVESLKCASMK----MAQLQLENKELESEKEQ 736
Query: 467 CKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQ----LQDLTEEKGT 522
K+ +E+LK S K +R + +D RL++ NKK +Q LQDL E T
Sbjct: 737 LKKGLELLKASF-KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 523 LAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTA 582
L + ++K + +++ L+K+ ++L+++ +K L+ K L+ + DT
Sbjct: 796 LQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 583 LATLEEALSEKERIIERLKEQ--RERDDRERLEEIESFRKENKDLKEKVNA--------- 631
L + E+ + L ++ ++ RL+E+E KENK+L ++
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE---KENKELVKRATIDIKTLVTLR 908
Query: 632 --LQAELTEKESSLIDLKEHASSLASAGLKR-----------------DSKLKS-LEIAI 671
L +E + + DL++ L GL + +SKL+S L+ ++
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968
Query: 672 EQKKEECSKLEAQLKKAHNI---------------------EDDSRM---NPEFADQIKQ 707
E K+E+ + LEA+L+++ N +D+ RM +P + + +
Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028
Query: 708 LDKEASYYRDECGKA--------------QAEVDRLLEILKEVENEKNDKDKKIAELESL 753
++E+ E K QAE L LK++E + N+ +I L+
Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 754 TLRHMKDQNKKVANLKHNQQLEK-----------KKNAQLL-EEVRRREDSMADNSQHLQ 801
T+ +++QN + Q+E +NAQLL ++ ++ + +
Sbjct: 1089 TV-SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERED 1147
Query: 802 IEELMNALEKTRQELDATKARLASTQQSLAEKEAHL----ANLRIERRKQLEEILEMKQE 857
++ L ++L K ++L+ R AS +SL K L NL +E R LE +
Sbjct: 1148 LKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD-----LEDRYN 1202
Query: 858 ALLAAISEKDANIALLELSASK---KKKTQEEVMA----LKREKDRLVHQLKQQTQNRMK 910
LL + + +L++ K + K E V A L E DRL H Q +
Sbjct: 1203 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1262
Query: 911 LMADN 915
L D+
Sbjct: 1263 LQTDH 1267
Score = 124 bits (311), Expect = 4e-28
Identities = 166/793 (20%), Positives = 348/793 (43%), Gaps = 88/793 (11%)
Query: 153 QLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRK--EEAARMSVLKEQ 210
+L EL++EN L+ +L + + I+ + E ++ +E+ + EQ
Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435
Query: 211 MRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHF--TIELTEENFRRLQA 268
+ + E ++ Q ++ +EL + R L ++ +S + E T++ E N ++
Sbjct: 436 ISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL- 494
Query: 269 EHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNER 328
+ KE L K +E +E I +KQ+L K L++ ++L +++ER
Sbjct: 495 ---KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
Query: 329 TRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIA 388
++ E E++ HL + ++ R ++ ++++ + K L I+ +K++
Sbjct: 552 QIKILEQENE--HL-----NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 389 SLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKES 448
+E R ++ E++ K G E+ E E+ +E ++ ++ KI LK K E
Sbjct: 605 KIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE---KENELLQKKITNLKITCEKIE- 659
Query: 449 ELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNK 508
AL+ + L +N K+ ++ K +LT + + +++D L L L
Sbjct: 660 ---ALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDEENLELRRNVESLKC 715
Query: 509 KTKQLQDLTEEKGTLAGEIRDMK---DMLEVKERKINVLQKKIENLQEQLRDKDKQLTNL 565
+ ++ L E L E +K ++L+ +K L+ + L + + K L N
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
Query: 566 KDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDL 625
+++ L+++ + + TL++ L E + +RL EQ E++++ +E K+ K L
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKKQL 834
Query: 626 KEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQL 685
+++ L+ + K+++L +++ L++++K S EI I KE C +L
Sbjct: 835 EKENKRLRQQAEIKDTTL-----EENNVKIGNLEKENKTLSKEIGI--YKESCVRL---- 883
Query: 686 KKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEK----- 740
K+L+KE ++ +A ++ L+ + +++ +EK
Sbjct: 884 --------------------KELEKE---NKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
Query: 741 --NDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQ 798
ND +K ELE + L + + + + + LE K + L + + +E+ +A +
Sbjct: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA--AL 978
Query: 799 HLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRI---------ERRKQLE 849
++EE N ++ RQEL K + +Q E+ ++ I E ++
Sbjct: 979 EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1038
Query: 850 EILEMKQEAL------LAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQ-LK 902
E+L++K + +EK A L+ ++ Q +++AL+R+ L Q
Sbjct: 1039 ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1098
Query: 903 QQTQNRMKLMADN 915
QTQN KL +N
Sbjct: 1099 LQTQN-AKLQVEN 1110
Score = 119 bits (298), Expect = 1e-26
Identities = 181/798 (22%), Positives = 358/798 (44%), Gaps = 130/798 (16%)
Query: 212 RVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGN-------------RGAEHFTIEL 258
R+ E ++H + I EL +RD H L S + +H ++EL
Sbjct: 199 RLIDERDEHSETII-----ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVEL 253
Query: 259 TEEN--FRRLQAEHDRQAKELFLLRKTLEEMELRIE-TQKQTLNARDESIKKLLEMLQSK 315
+ RRL+ E + + ++L ++ LE+ME+ ++ Q++ +N LL +S
Sbjct: 254 ADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMN--------LLSDARSA 305
Query: 316 GLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKE--KENI-HLREE----LHRRSQLQP 368
+ L+ E+ R+ + ES+VS + L E K + L+E+ L ++ L+
Sbjct: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 369 EPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSH 428
+ T+A + + + L+ + D+E E M + E+ EE +E+ +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK----KIEELMEENMTLEMAQKQ 421
Query: 429 SK----FMKTKIDQLKQ--ELSKKESELLA------LQTKLETLSNQNSDCKQHIEVLKE 476
S + +++Q+ + ELS+ + L ++L L +N + +E L+
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 477 SLTAKEQRAA-ILQTEVDALRLR----------LEEKESFLNKKTKQLQDLTEEKGTLAG 525
++ + E A+ IL+ E + RL ++EK+S N + +DL +EK L
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS-KDLMKEKAQLEK 540
Query: 526 EIRDMKDMLEVKERKINVLQKKIENLQEQLRD-KDKQLTNLKDRVKSLQTDSSNTDTALA 584
I ++ E ER+I +L+++ E+L + + + + + + RVK ++ ++ ++
Sbjct: 541 TIETLR---ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 585 TLEEALS----EKERIIERLKEQRERDDR-ERLE-EIESFRKENKDLKEKVNALQAELTE 638
LS EK +I + L+ +E+ +R E LE E+ KEN+ L++K+ L+ +
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK 657
Query: 639 KESSLIDLKEHASSLASAGLKRDSKL---KSLEIAIEQKKEECSKL-EAQLKKAHNIEDD 694
E+ L++ S L K L K+L +E ++E S+L E L+ N+E
Sbjct: 658 IEA----LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 695 SRMNPEFAD---QIKQLDKEASYYRD--ECGKAQAEVDRLLEIL---KEVENEKNDK--- 743
+ + A + K+L+ E + E KA + LE+ ++EN++ K
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773
Query: 744 --DKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ 801
+KKI +LES ++D + L+ N + E K +++ LE++ + S
Sbjct: 774 NSNKKIQQLES----ELQDLEMENQTLQKNLE-ELKISSKRLEQLEKENKS--------- 819
Query: 802 IEELMNALEKTRQELDATKARLASTQQ----SLAEKEAHLANLRIERRK----------- 846
+E+ + LEK +++L+ RL + +L E + NL E +
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 847 --QLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQ 904
+L+E+ + +E + A + + L E S+K KTQ+ + + ++L H+L++
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ----MNNDLEKLTHELEKI 935
Query: 905 TQNRMKLMADNYDDDHHH 922
N+ +L+ D D +
Sbjct: 936 GLNKERLLHDEQSTDDRY 953
Score = 75.5 bits (184), Expect = 2e-13
Identities = 96/440 (21%), Positives = 191/440 (43%), Gaps = 47/440 (10%)
Query: 141 QVRDSTMLDLQAQLKELQRENDLLRKELD--------IKDSKLGSSMNSIKTFWSPELKK 192
++++ + L+A+L+E N LR+EL +K + M S E K
Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028
Query: 193 ERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAE 252
+E + +K+++ N LQ QAL+ +L+ N+ LQ + +
Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI--LALQ 1086
Query: 253 HFTIELTEENFRRLQAEHDRQAKELFLLRK---TLEEMELRIETQKQTLNARDESIKKLL 309
T+ L E+N LQ ++ + E L +L ++ Q+ +L +ES+ K
Sbjct: 1087 RQTVSLQEQN-TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1145
Query: 310 EMLQSKGLPSKSLEDDNERT-----RRMAEAESQVSHLEVILDQKEKENIHLREELHRRS 364
E L+S SL D+E+ R+ +E ES +S + + + R+ R +
Sbjct: 1146 EDLKSL---YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1202
Query: 365 QLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV 424
QL + + + L+ +++++ K+ +N + E + L + +K+ EV
Sbjct: 1203 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1262
Query: 425 YKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQR 484
++ K +K+ ++ K E ++ E+E L+ + + L ++ E+L +
Sbjct: 1263 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ-------- 1314
Query: 485 AAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKER----K 540
L+ LEE+ L Q+Q L + TL + + KD+ V++R K
Sbjct: 1315 ----------LKGNLEEENRHL---LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1361
Query: 541 INVLQKKIENLQEQLRDKDK 560
+N L+++ E L+E++ D+ K
Sbjct: 1362 LNELRRQKEKLEEKIMDQYK 1381
Score = 68.6 bits (166), Expect = 3e-11
Identities = 90/433 (20%), Positives = 193/433 (44%), Gaps = 50/433 (11%)
Query: 497 LRLEEKESFLNKKTKQLQDLT-EEKGTLAGEIRDM----KDMLEVKERKI-NVLQKKIEN 550
++ ++KE F+ + +Q L + K +A I+++ +++ +++ ++ ++ Q+ IE
Sbjct: 133 VQCQKKEEFIER----IQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEP 188
Query: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRE 610
L + + K+L + +D + S L L A S + +
Sbjct: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQ-------SPCGSPGMK 241
Query: 611 RLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIA 670
R E + E D K K+ L+ EL EK L+D K+ +L+ +EI
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQ--------------ELEQMEIE 287
Query: 671 IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQ---AEVD 727
+++ ++E L + + A D+ E A ++ +L+ E S Y++ + A V+
Sbjct: 288 LKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVE 347
Query: 728 RLLE---ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLE 784
L E +L E + D+ + S L ++ +N ++ H+ ++E+ + + +E
Sbjct: 348 ELKEDNQVLLETKTMLEDQ-LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 785 EVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIER 844
E+ E+ + +Q ++E ++ L +++ T + Q+SL + L + R+ +
Sbjct: 407 EL-MEENMTLEMAQKQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 845 RKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQL--- 901
LEM+ ++L + E + +E +ASK K ++E L ++ + L +++
Sbjct: 465 -------LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 902 KQQTQNRMKLMAD 914
KQ QN L D
Sbjct: 518 KQSLQNCQNLSKD 530
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 140 bits (352), Expect = 7e-33
Identities = 206/874 (23%), Positives = 392/874 (44%), Gaps = 151/874 (17%)
Query: 129 HHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSP 188
+ H +Q S LRQ + + +A++K++++EN +L + + SKL S F
Sbjct: 560 NEHLNQTVSSLRQ---RSQISAEARVKDIEKENKILHESIKETSSKL-----SKIEFEKR 611
Query: 189 ELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGN 248
++KKE KE+ R L+ ++ +EN+ LQ I L+ + L+QE+
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKI----TNLKITCEKIEALEQENSE 667
Query: 249 RGAEHFTIELTEENFRR-------LQAEHDRQAKELFLLRKTLEEME------LRIETQK 295
E+ ++ T ++F+ L+ E+ + +E LR+ +E ++ +++ +
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 296 QTLNARDESIKKLLEMLQS------------KGLP------SKSLEDDNERTRRM----- 332
+ L + E +KK LE+L++ +GL K+LE+ N++ +++
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 333 -AEAESQV--SHLEVI------LDQKEKENIHLREELHR----RSQLQPEPAKTKALQTV 379
E E+Q +LE + L+Q EKEN L +E + + QL+ E K L+
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE---NKRLRQQ 844
Query: 380 IEMKDT-------KIASLERNIRDLEDEIQMLKANGV----LNTEDRE------EEIKQI 422
E+KDT KI +LE+ + L EI + K + V L E++E +IK +
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 423 EVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETL--SNQNSDCKQH-------IEV 473
+ K K Q+ +L K EL + E L Q++D ++
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST 964
Query: 474 LKESLTAKEQRAAILQTEVDA-----LRLRLEEKESFLN-KKTKQLQD---LTEEKGTLA 524
LK+SL KE++ A L+ ++ +LR E K N + KQ QD + + ++
Sbjct: 965 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1024
Query: 525 GE--------IRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDS 576
GE +++L+VK+R I V ++ LQ +KQ LK ++K L+T +
Sbjct: 1025 GEDNKWERESQETTRELLKVKDRLIEV-ERNNATLQ-----AEKQA--LKTQLKQLETQN 1076
Query: 577 SNTDTALATLEE---ALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQ 633
+N + L+ +L E+ ++ + + ++ + S +N L + Q
Sbjct: 1077 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ----Q 1132
Query: 634 AELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAH-NIE 692
+ L + S+I +E SL + +K KL+ L + E LK AH N+E
Sbjct: 1133 SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLE 1192
Query: 693 DDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELES 752
+ R + D+ QL K+ D LE + +VE EK + K E +
Sbjct: 1193 VEHR---DLEDRYNQLLKQKGQLED------------LEKMLKVEQEKMLLENKNHETVA 1237
Query: 753 LTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNS--QHLQIEELMNALE 810
+ + +N ++ N ++Q L K ++L+ + S+ +NS + ++E + L+
Sbjct: 1238 AEYKKLCGENDRL-NHTYSQLL---KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
Query: 811 KTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANI 870
+ Q+LD T +L + + L++ + NL E R L++I Q +L + + N+
Sbjct: 1294 EQYQQLDITSTKLNNQCELLSQLK---GNLEEENRHLLDQI----QTLMLQNRTLLEQNM 1346
Query: 871 ALLELSASKKKKTQEEVMALKREKDRLVHQLKQQ 904
+L ++++ +++ L+R+K++L ++ Q
Sbjct: 1347 ESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
Score = 128 bits (321), Expect = 3e-29
Identities = 179/788 (22%), Positives = 354/788 (44%), Gaps = 116/788 (14%)
Query: 189 ELKKERVLR-KEEAARMSVLKEQMRVSHEENQHL---QLTIQALQDELRTQRDLNHLLQQ 244
E K E++L K+E +M + +++ +EN +L + + +DEL R+ ++
Sbjct: 268 EEKTEQLLDCKQELEQMEI---ELKRLQQENMNLLSDARSARMYRDELDALRE--KAVRV 322
Query: 245 ESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDES 304
+ + L + F + + E ++ ++ L KT+ +E Q + AR +
Sbjct: 323 DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM------LEDQLEGTRARSDK 376
Query: 305 IKKL-LEMLQSKG-LPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLR---EE 359
+ +L E LQ K L +E D +R +++ E + LE+ Q E++HL E+
Sbjct: 377 LHELEKENLQLKAKLHDMEMERDMDR-KKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435
Query: 360 LHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEI 419
+ R S+L P K+ + V E+ +++ LE + L ++ L+ V + E +I
Sbjct: 436 ISRTSELSEAPQKSLGHE-VNELTSSRLLKLEMENQSLTKTVEELRTT-VDSVEGNASKI 493
Query: 420 KQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLT 479
++E K + + K K++ L+ E+ +++ L Q + L + + ++ IE L+E+
Sbjct: 494 LKME--KENQRLSK-KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN-- 548
Query: 480 AKEQRAAILQTEVDALRLRLEEKESFLNKKTK-----QLQDLTEEKGTLAGEIRDMKDML 534
E++ IL+ E + L + S L ++++ +++D+ +E L I++ L
Sbjct: 549 -SERQIKILEQENE----HLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
Query: 535 EVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKE 594
KI +++I+ E ++K ++ L++ + L+ ++ + L+ EK
Sbjct: 604 S----KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK-ITCEKI 658
Query: 595 RIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLA 654
+E+ + ER++R+ + ++SF K+L ++ +L+ E ++ + ++L+ + SL
Sbjct: 659 EALEQENSELERENRKLKKTLDSF----KNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Query: 655 SAGLKRDS---KLKSLEIAIEQKKEECSKLEAQLKKAHNIE--------DDSRMNPEFAD 703
A +K + K LE EQ K+ L+A KK +E ++ R+ +
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 704 ---QIKQLDKEASYYRDECGKAQAEVDRL------LEILK------EVENEKNDKDKKIA 748
+I+QL+ E E Q ++ L LE L+ E E + +KDKK
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL 834
Query: 749 ELESLTLRH--------MKDQNKKVANL-------------------------KHNQQLE 775
E E+ LR +++ N K+ NL K N++L
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 776 KKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELD---ATKARLASTQQSLAE 832
K+ + V RED + S+ L+ +++ N LEK EL+ K RL +QS +
Sbjct: 895 KRATIDIKTLVTLREDLV---SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
Query: 833 KEAHLANLRIERRKQLEEILEMKQE--ALLAAISEKDANIALLELSASKKKKTQEEVMAL 890
L ++E L++ LE+K+E A L A E+ N K K E +
Sbjct: 952 SRYKLLESKLE--STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009
Query: 891 KREKDRLV 898
+++++R+V
Sbjct: 1010 RQDEERMV 1017
Score = 126 bits (317), Expect = 8e-29
Identities = 205/906 (22%), Positives = 380/906 (41%), Gaps = 160/906 (17%)
Query: 148 LDLQAQLKELQRENDLLRKELD--------IKDSKLGSSMNSIKTFWSPELKKERVLRKE 199
L L+A+L +++ E D+ RK+++ ++ ++ S S+ W E + R
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE-QISRTSELS 443
Query: 200 EAARMSVLKEQMRVSHEENQHLQLTIQALQ---DELRTQRD-----LNHLLQQESGNRGA 251
EA + S+ E ++ L++ Q+L +ELRT D + +L+ E N+
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 252 EHFTIELTEENFRRLQAEHDRQ------AKELFLLRKTLEEMELRIETQKQTLNARDESI 305
L E + Q+ + Q KE L KT+E + E Q + L +E +
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 306 KKLLEMLQSKGLPS-----KSLEDDNERTRR-MAEAESQVSHLEVILDQKEKENIHLREE 359
+ + L+ + S K +E +N+ + E S++S +E Q +KE H +E+
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 360 LHRRSQLQPEPAKTKALQTVIEMKDT-------KIASLERNIRDLEDEIQMLK------A 406
R +L+ E + +++ K T KI +LE+ +LE E + LK
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 407 NGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSD 466
N E E+E Q++ + ++ ++ LK K + LQ + + L ++
Sbjct: 684 NLTFQLESLEKENSQLD---EENLELRRNVESLKCASMK----MAQLQLENKELESEKEQ 736
Query: 467 CKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQ----LQDLTEEKGT 522
K+ +E+LK S K +R + +D RL++ NKK +Q LQDL E T
Sbjct: 737 LKKGLELLKASF-KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 523 LAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTA 582
L + ++K + +++ L+K+ ++L+++ +K L+ K L+ + DT
Sbjct: 796 LQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 583 LATLEEALSEKERIIERLKEQ--RERDDRERLEEIESFRKENKDLKEKVNA--------- 631
L + E+ + L ++ ++ RL+E+E KENK+L ++
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE---KENKELVKRATIDIKTLVTLR 908
Query: 632 --LQAELTEKESSLIDLKEHASSLASAGLKR------------------DSKLKS-LEIA 670
L +E + + DL++ L GL + +SKL+S L+ +
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968
Query: 671 IEQKKEECSKLEAQLKKAHNI---------------------EDDSRM---NPEFADQIK 706
+E K+E+ + LEA+L+++ N +D+ RM +P + +
Sbjct: 969 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1028
Query: 707 QLDKEASYYRDECGKA--------------QAEVDRLLEILKEVENEKNDKDKKIAELES 752
+ ++E+ E K QAE L LK++E + N+ +I L+
Sbjct: 1029 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1088
Query: 753 LTLRHMKDQNKKVANLKHNQQLEK-----------KKNAQLL-EEVRRREDSMADNSQHL 800
T+ +++QN + Q+E +NAQLL ++ ++ + +
Sbjct: 1089 QTV-SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147
Query: 801 QIEELMNALEKTRQELDATKARLASTQQSLAEKEAHL----ANLRIERRKQLEEILEMKQ 856
++ L ++L K ++L+ R AS +SL K L NL +E R LE +
Sbjct: 1148 DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD-----LEDRY 1202
Query: 857 EALLAAISEKDANIALLELSASK---KKKTQEEVMA----LKREKDRLVHQLKQQTQNRM 909
LL + + +L++ K + K E V A L E DRL H Q +
Sbjct: 1203 NQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE 1262
Query: 910 KLMADN 915
L D+
Sbjct: 1263 VLQTDH 1268
Score = 120 bits (302), Expect = 5e-27
Identities = 182/799 (22%), Positives = 358/799 (44%), Gaps = 130/799 (16%)
Query: 212 RVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGN-------------RGAEHFTIEL 258
R+ E ++H + I EL +RD H L S + +H ++EL
Sbjct: 199 RLIDERDEHSETII-----ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVEL 253
Query: 259 TEEN--FRRLQAEHDRQAKELFLLRKTLEEMELRIE-TQKQTLNARDESIKKLLEMLQSK 315
+ RRL+ E + + ++L ++ LE+ME+ ++ Q++ +N LL +S
Sbjct: 254 ADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMN--------LLSDARSA 305
Query: 316 GLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKE--KENI-HLREE----LHRRSQLQP 368
+ L+ E+ R+ + ES+VS + L E K + L+E+ L ++ L+
Sbjct: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 369 EPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSH 428
+ T+A + + + L+ + D+E E M + E+ EE +E+ +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK----KIEELMEENMTLEMAQKQ 421
Query: 429 SK----FMKTKIDQLKQ--ELSKKESELLA------LQTKLETLSNQNSDCKQHIEVLKE 476
S + +++Q+ + ELS+ + L ++L L +N + +E L+
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 477 SLTAKEQRAA-ILQTEVDALRLR----------LEEKESFLNKKTKQLQDLTEEKGTLAG 525
++ + E A+ IL+ E + RL ++EK+S N + +DL +EK L
Sbjct: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS-KDLMKEKAQLEK 540
Query: 526 EIRDMKDMLEVKERKINVLQKKIENLQEQLRD-KDKQLTNLKDRVKSLQTDSSNTDTALA 584
I ++ E ER+I +L+++ E+L + + + + + + RVK ++ ++ ++
Sbjct: 541 TIETLR---ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 585 TLEEALS----EKERIIERLKEQRERDDR-ERLE-EIESFRKENKDLKEKVNALQAELTE 638
LS EK +I + L+ +E+ +R E LE E+ KEN+ L++K+ L+ +
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK 657
Query: 639 KESSLIDLKEHASSLASAGLKRDSKL---KSLEIAIEQKKEECSKL-EAQLKKAHNIEDD 694
E+ L++ S L K L K+L +E ++E S+L E L+ N+E
Sbjct: 658 IEA----LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 695 SRMNPEFAD---QIKQLDKEASYYRD--ECGKAQAEVDRLLEIL---KEVENEKNDK--- 743
+ + A + K+L+ E + E KA + LE+ ++EN++ K
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773
Query: 744 --DKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ 801
+KKI +LES ++D + L+ N + E K +++ LE++ + S
Sbjct: 774 NSNKKIQQLES----ELQDLEMENQTLQKNLE-ELKISSKRLEQLEKENKS--------- 819
Query: 802 IEELMNALEKTRQELDATKARLASTQQ----SLAEKEAHLANLRIERRK----------- 846
+E+ + LEK +++L+ RL + +L E + NL E +
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 847 --QLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQ 904
+L+E+ + +E + A + + L E S+K KTQ+ + + ++L H+L++
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ----MNNDLEKLTHELEKI 935
Query: 905 TQNRMKLMADNYDDDHHHY 923
N+ +L+ D D Y
Sbjct: 936 GLNKERLLHDEQSTDDSRY 954
Score = 75.5 bits (184), Expect = 2e-13
Identities = 96/440 (21%), Positives = 191/440 (43%), Gaps = 47/440 (10%)
Query: 141 QVRDSTMLDLQAQLKELQRENDLLRKELD--------IKDSKLGSSMNSIKTFWSPELKK 192
++++ + L+A+L+E N LR+EL +K + M S E K
Sbjct: 970 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1029
Query: 193 ERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAE 252
+E + +K+++ N LQ QAL+ +L+ N+ LQ + +
Sbjct: 1030 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI--LALQ 1087
Query: 253 HFTIELTEENFRRLQAEHDRQAKELFLLRK---TLEEMELRIETQKQTLNARDESIKKLL 309
T+ L E+N LQ ++ + E L +L ++ Q+ +L +ES+ K
Sbjct: 1088 RQTVSLQEQN-TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1146
Query: 310 EMLQSKGLPSKSLEDDNERT-----RRMAEAESQVSHLEVILDQKEKENIHLREELHRRS 364
E L+S SL D+E+ R+ +E ES +S + + + R+ R +
Sbjct: 1147 EDLKSL---YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 365 QLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV 424
QL + + + L+ +++++ K+ +N + E + L + +K+ EV
Sbjct: 1204 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1263
Query: 425 YKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQR 484
++ K +K+ ++ K E ++ E+E L+ + + L ++ E+L +
Sbjct: 1264 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ-------- 1315
Query: 485 AAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKER----K 540
L+ LEE+ L Q+Q L + TL + + KD+ V++R K
Sbjct: 1316 ----------LKGNLEEENRHL---LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1362
Query: 541 INVLQKKIENLQEQLRDKDK 560
+N L+++ E L+E++ D+ K
Sbjct: 1363 LNELRRQKEKLEEKIMDQYK 1382
Score = 68.6 bits (166), Expect = 3e-11
Identities = 90/433 (20%), Positives = 193/433 (44%), Gaps = 50/433 (11%)
Query: 497 LRLEEKESFLNKKTKQLQDLT-EEKGTLAGEIRDM----KDMLEVKERKI-NVLQKKIEN 550
++ ++KE F+ + +Q L + K +A I+++ +++ +++ ++ ++ Q+ IE
Sbjct: 133 VQCQKKEEFIER----IQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEP 188
Query: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRE 610
L + + K+L + +D + S L L A S + +
Sbjct: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQ-------SPCGSPGMK 241
Query: 611 RLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIA 670
R E + E D K K+ L+ EL EK L+D K+ +L+ +EI
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQ--------------ELEQMEIE 287
Query: 671 IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQ---AEVD 727
+++ ++E L + + A D+ E A ++ +L+ E S Y++ + A V+
Sbjct: 288 LKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVE 347
Query: 728 RLLE---ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLE 784
L E +L E + D+ + S L ++ +N ++ H+ ++E+ + + +E
Sbjct: 348 ELKEDNQVLLETKTMLEDQ-LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 785 EVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIER 844
E+ E+ + +Q ++E ++ L +++ T + Q+SL + L + R+ +
Sbjct: 407 EL-MEENMTLEMAQKQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 845 RKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQL--- 901
LEM+ ++L + E + +E +ASK K ++E L ++ + L +++
Sbjct: 465 -------LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 902 KQQTQNRMKLMAD 914
KQ QN L D
Sbjct: 518 KQSLQNCQNLSKD 530
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 137 bits (344), Expect = 6e-32
Identities = 169/847 (19%), Positives = 361/847 (42%), Gaps = 110/847 (12%)
Query: 134 QVPSMLRQVRDS--TMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELK 191
+V +R RDS + + L++ E Q E + KE +L + ++ S LK
Sbjct: 378 EVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKE----KMRLEGQLEALSLEASQALK 433
Query: 192 KERVLRKEEAARMSVLKEQMRVSHEENQH-------LQLTIQALQDELRTQRDLNHLLQQ 244
++ L+ + AA + L+ Q+ SH Q + Q+ D R DL ++L+
Sbjct: 434 EKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEA 493
Query: 245 ESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELR---IETQKQTLNAR 301
++ + + + +++ EE ++RL A+ + + + T+ ++ + +++Q Q +
Sbjct: 494 KNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLE 553
Query: 302 DESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEA-----ESQVSHLEV-------ILDQK 349
++ L+ Q++ +S+ ++ +A+ + +++H++V +L+
Sbjct: 554 RTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHL 613
Query: 350 EKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGV 409
+ EN+ L ++L ++ Q K K ++ +E ++ D E ++
Sbjct: 614 KLENVSLSQQL---TETQHRSMKEKGRIAA------QLQGIEADMLDQEAAFMQIQEAKT 664
Query: 410 LNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQ 469
+ ED + +++ E + + M L+Q+L + + LL +LE L ++ D +
Sbjct: 665 MVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMK 724
Query: 470 HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRD 529
+ + +E+L ++EQ LQT D L+ RL E + + + L EK L ++
Sbjct: 725 QLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784
Query: 530 MKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEA 589
K E +R L++ E E L ++L +V+ LQ +++ + ++E
Sbjct: 785 AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
Query: 590 L--------------SEKERIIERLKEQRERDD---RERLEEIESFRKENKDLKEKVNAL 632
+ K+++I LK R+R D +E +E+ E + + +++ L
Sbjct: 845 FLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRL 904
Query: 633 QAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQK----------KEECSKLE 682
E+ + + DL+ H S + ++ L+SL+ EQ K++ +L+
Sbjct: 905 HREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQ 964
Query: 683 AQLKKAHNIEDDS--RMNPEFADQIKQLDKEASYYRDECG--------------KAQAEV 726
+ +KA + R+ + K++ + Y + G A AE+
Sbjct: 965 QEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAEL 1024
Query: 727 DRL-------------------LEI-LKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA 766
+L LE L+ V + K +K++ E+ +LT + +++ +KV
Sbjct: 1025 GQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL 1084
Query: 767 NLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLAST 826
L+ E +++ ++++R E+S + L++E L Q A + +
Sbjct: 1085 ELED----ELQESRGFRKKIKRLEES--NKKLALELEHEKGKLTGLGQSNAALREHNSIL 1138
Query: 827 QQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEE 886
+ +LA++EA L L + Q++ +L+ K+E A A LE K +E+
Sbjct: 1139 ETALAKREADLVQLNL----QVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQ 1194
Query: 887 VMALKRE 893
V A K E
Sbjct: 1195 VAAAKVE 1201
Score = 106 bits (265), Expect = 9e-23
Identities = 169/763 (22%), Positives = 327/763 (42%), Gaps = 116/763 (15%)
Query: 149 DLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMS--V 206
DLQ +L+E + E + L++ D S L + +K ++ L++E M
Sbjct: 669 DLQRRLEEFEGERERLQRMADSAAS-LEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLT 727
Query: 207 LKEQMRVSHEEN--------QHLQLTIQALQDELRTQRDLNHLLQQE-----SGNRGAEH 253
L ++ S E++ LQ + LQ E ++ D LLQ E + + A+
Sbjct: 728 LTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKS 787
Query: 254 FTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIET-QKQTLNARDESIKKLLEML 312
EL + RRL+ + ++ L LR+ EL I++ Q + L ++KK ++ +
Sbjct: 788 GKEEL-DRGARRLEEGTEETSETLEKLRE-----ELAIKSGQVEHLQQETAALKKQMQKI 841
Query: 313 QSKGLPSKSLEDDNERTRRMAEAESQ-VSHLEVILDQKEKENIHLREELHR-RSQLQPEP 370
+ + L K + E RR A ++ Q +S L+ + + E LR+EL + + +
Sbjct: 842 KEQFLQQKVMV---EAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAE 898
Query: 371 AKTKALQTVIEMKDTKIASLERNIRDLEDE----------IQMLKANGVLNTEDREEEIK 420
A+ L + +A LE +++ + E +Q K V TE E K
Sbjct: 899 AELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKK 958
Query: 421 QIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEV-LKESLT 479
QIE + ++ I + KQ++ + S+L + Q +++T + + L+E+L
Sbjct: 959 QIEELQQEAR---KAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALA 1015
Query: 480 AKEQRAA----------------ILQTEVDALRLRLE---EKESFLNKKTKQLQDLTEEK 520
AKE A L + AL L+ ++ L K+ +++ LT ++
Sbjct: 1016 AKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQE 1075
Query: 521 GTLAGE-IRDMKDMLEVKE---RKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDS 576
+ E + +++D L+ +KI L++ + L +L + +LT L +L+ +
Sbjct: 1076 LEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHN 1135
Query: 577 SNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAEL 636
S +TALA E L + ++ + +++E +DR+ +++ + + KEKVN+L+ ++
Sbjct: 1136 SILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQV 1195
Query: 637 TEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSR 696
A+ + + +R K SLE++ E KKE +K K +D
Sbjct: 1196 A------------AAKVEAGHNRRHFKAASLELS-EVKKELQAKEHLVQKLQAEADDLQI 1242
Query: 697 MNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEIL----KEVENEKNDKDKKIAELES 752
+ + +I Q E + R + Q ++D L +E+EN K + D+K E++S
Sbjct: 1243 REGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
Query: 753 LTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKT 812
L K+ L E+ R+E +E L L+
Sbjct: 1303 L-----------------------KQQLDLTEQQGRKE-----------LEGLQQLLQNV 1328
Query: 813 RQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMK 855
+ EL+ + L+ TQ+ +A ++ L+ + L++ ++K
Sbjct: 1329 KSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLK 1371
Score = 79.3 bits (194), Expect = 2e-14
Identities = 116/537 (21%), Positives = 220/537 (40%), Gaps = 101/537 (18%)
Query: 410 LNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQ 469
L + E + + ++V K + ++ +++ L E S+ E LQ +L LS +
Sbjct: 396 LESSAAETQEEMLQVLKEKMR-LEGQLEALSLEASQALKEKAELQAQLAALSTK------ 448
Query: 470 HIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKG-TLAGEIR 528
++ E + +QR L +EVD L+ + L + LQ++ E K +LA
Sbjct: 449 -LQAQVECSHSSQQRQDSLSSEVDTLKQSCWD----LERAMTDLQNMLEAKNASLASSNN 503
Query: 529 DMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEE 588
D L+V E + L K+E++Q + KD + +L+ ++ +LQ+ TL
Sbjct: 504 D----LQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTS 559
Query: 589 ALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKE 648
L + I L+ R+ ++++ +E LQ E+ +
Sbjct: 560 KLKASQAEISSLQSVRQW-----------YQQQLALAQEARVRLQGEMAHIQ-------- 600
Query: 649 HASSLASAGLKRDSKLKSLEIAIE------QKKEECSKLEAQLKKAHNIEDDSRMNPEFA 702
+ AGL KL+++ ++ + + +E ++ AQL+ IE D
Sbjct: 601 -VGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQ---GIEAD-------- 648
Query: 703 DQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQN 762
LD+EA++ + + K E D L L+E E E+ + SL + +
Sbjct: 649 ----MLDQEAAFMQIQEAKTMVEED-LQRRLEEFEGERERLQRMADSAASL---EQQLEQ 700
Query: 763 KKVANLKHNQQLE--KKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATK 820
K+ L+ +QQLE ++++ L++++ ++++ Q +L+ + D +
Sbjct: 701 VKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQ---------SLDALQTHYDELQ 751
Query: 821 ARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKK 880
ARL Q A +E + L+ E+ ILE +A + E D LE +
Sbjct: 752 ARLGELQGEAASREDTICLLQNEKI-----ILEAALQAAKSGKEELDRGARRLEEGTEET 806
Query: 881 KKT------------------QEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDD 919
+T Q+E ALK++ ++ Q QQ K+M + Y D
Sbjct: 807 SETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQ-----KVMVEAYRRD 858
Score = 35.4 bits (80), Expect = 0.26
Identities = 42/177 (23%), Positives = 72/177 (40%), Gaps = 20/177 (11%)
Query: 734 KEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNA------QLLEEVR 787
+EV E + I SL + Q + + LK +LE + A Q L+E
Sbjct: 377 QEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKA 436
Query: 788 RREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQ 847
+ +A S LQ + + ++Q D+ + + + +QS + E + +L
Sbjct: 437 ELQAQLAALSTKLQAQ--VECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDL------- 487
Query: 848 LEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQ 904
+ +LE K +L A S D +A E + E++ KD VH L+QQ
Sbjct: 488 -QNMLEAKNASL--ASSNNDLQVA--EEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQ 539
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 136 bits (343), Expect = 8e-32
Identities = 178/822 (21%), Positives = 344/822 (41%), Gaps = 114/822 (13%)
Query: 152 AQLKELQR-------ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARM 204
A++KEL++ + D L++EL+ D+++ + + EL+K+ LR +E A +
Sbjct: 464 ARIKELEQSLLFEKTKADKLQRELE--DTRVATVSEKSRIM---ELEKDLALRVQEVAEL 518
Query: 205 SVLKEQMRVSHEENQHLQLT--IQALQDELRT-----QRDLNHLLQQESGNRGAEHFTIE 257
E + + + + L L I +LQ++L QR++ L + I+
Sbjct: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 578
Query: 258 LTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 317
+L E++ +L K ++ +++ +T A + + L++ SKGL
Sbjct: 579 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638
Query: 318 PSKSLE-------------------------DDNERTRRMAEAESQVSHLEVILDQKEK- 351
+++ E D+ER E E+ + L ++ +KE
Sbjct: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698
Query: 352 -----------ENIHLREELHRRSQLQPEPAKTKALQT----------VIEMKDTKIASL 390
E+ HL E ++LQ K K L+ VI+ +++ +
Sbjct: 699 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758
Query: 391 ERNIRDL--------EDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQE 442
E + DL E + +M K L E E++IK +E+ K+ +K + +E
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKKLRQQL--EAAEKQIKHLEIEKNAES---SKASSITRE 813
Query: 443 LSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 502
L +E +L LQ L +S ++ +++LKE + A +Q + +L +K
Sbjct: 814 LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 873
Query: 503 ESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQL 562
E N + L+ L E + + R+ + E + L+ I + + D QL
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 933
Query: 563 TNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKEN 622
T + D ++ + D L E S ++ IE + + E+ +E ++ E +E
Sbjct: 934 TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHE---EEK 990
Query: 623 KDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLE 682
K+L+ K++ L+ ++ + +LK S ++K K EI ++ ++ E
Sbjct: 991 KELERKLSDLEKKMETSHNQCQELKARYERATS-----ETKTKHEEI-LQNLQKTLLDTE 1044
Query: 683 AQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKND 742
+LK A E++S + E + KQ DK KA + ++I++++ EK +
Sbjct: 1045 DKLKGAR--EENSGLLQELEELRKQADK---------AKAAQTAEDAMQIMEQMTKEKTE 1093
Query: 743 KDKKIAELESLTLRHMKDQNK----KVANLKHNQQLEKKKNA-----QLLEEVRRREDSM 793
+A LE + K QN+ K NLK+ ++L K K Q +EE R+ +++
Sbjct: 1094 ---TLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1150
Query: 794 --ADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEI 851
A + Q+ L K +EL ++ + S Q L E+ + L N +E +K+ +
Sbjct: 1151 KQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS-HQKLEEERSVLNNQLLEMKKRESKF 1209
Query: 852 LEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKRE 893
++ E + ALL ++ +K + EV L+ E
Sbjct: 1210 IKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE 1251
Score = 105 bits (263), Expect = 2e-22
Identities = 133/644 (20%), Positives = 291/644 (45%), Gaps = 52/644 (8%)
Query: 280 LRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNE-RTRRMAEAESQ 338
L++ L+E + IE Q L RD ++ + G + L + + + E E++
Sbjct: 353 LQEALKEKQQHIE---QLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK 409
Query: 339 VSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398
+ L +++ ++E + L +QL+ E K + LQ +E + LE +
Sbjct: 410 MDQLRTMVEAADREKVELL------NQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEH 463
Query: 399 DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE 458
I+ L+ + + ++ +++E + + K++I +L+++L+ + E+ L+ +LE
Sbjct: 464 ARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLE 523
Query: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAIL---QTEVDALRLRLEEKESFLNKKTKQLQD 515
+ + D + +L+E + +E+ Q E+ +L+ +E K+ K L
Sbjct: 524 S-NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 582
Query: 516 LTEEKGTLAGEIRDMKDMLE-VKERKINVLQKKIENLQEQLRDKDKQLTNLK-DRVKSLQ 573
TE+ L+ E +K LE + +V+ L+ + + + LK K L
Sbjct: 583 ATEK---LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLG 639
Query: 574 TDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFR-KENKDLKEKVNAL 632
T+++ +E+ + + IE L+ Q++ + +E+E+ R K K +KEK N+L
Sbjct: 640 TETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSL 699
Query: 633 QAELTE----KESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKA 688
+A ++ ++ L+++++ + L A + K+K LE+ +K Q K
Sbjct: 700 EAIRSKLDKAEDQHLVEMEDTLNKLQEA----EIKVKELEVL-------QAKCNEQTKVI 748
Query: 689 HNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIA 748
N + E + L K +S + E K + +++ + +K +E EKN + K +
Sbjct: 749 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 808
Query: 749 ELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHL-----QIE 803
+ R ++ + K+ NL+ N + L +E++ ++ A+ S+ ++
Sbjct: 809 SI----TRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 864
Query: 804 ELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAI 863
E +N L + ++ + + L +++LA+ EA + ER +QL + E K E +A I
Sbjct: 865 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE-KDEREEQLIKAKE-KLENDIAEI 922
Query: 864 SEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQN 907
+ + ++S+ K +E+ +R+ + L +L + +N
Sbjct: 923 MKMSGD------NSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
Score = 99.0 bits (245), Expect = 2e-20
Identities = 131/614 (21%), Positives = 261/614 (42%), Gaps = 92/614 (14%)
Query: 141 QVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLG-SSMNSIKTFWSPELKKERVLRKE 199
Q R+ + +LQ L E+ + + L KEL I K +S ++ S + ++ +KE
Sbjct: 815 QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKE 874
Query: 200 EAARM-SVLKEQMRVS--------HEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRG 250
E M S E++R + E+++ + I+A + + + D+ +++ N
Sbjct: 875 EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE---KLENDIAEIMKMSGDNSS 931
Query: 251 A---EHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKK 307
+ + L E + LQ + + + L+K++E+M ++ E +Q + E KK
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 991
Query: 308 LLEM----LQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVI-------LDQKEK----- 351
LE L+ K S + + + A +E++ H E++ LD ++K
Sbjct: 992 ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR 1051
Query: 352 -ENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVL 410
EN L +EL +L+ + K KA QT ED +Q+++
Sbjct: 1052 EENSGLLQELE---ELRKQADKAKAAQTA------------------EDAMQIMEQM--- 1087
Query: 411 NTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQH 470
T+++ E + +E K + ++ ++D LK+ K EL + L + + + ++
Sbjct: 1088 -TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 1146
Query: 471 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM 530
IE LK++ K Q+ + LQ E ++L E+ + Q L EE+ L ++ +M
Sbjct: 1147 IETLKQAAAQKSQQLSALQEE----NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1202
Query: 531 KD-----MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALAT 585
K + + E K + LQK I L +KD +L L++ V L+ ++++ + +
Sbjct: 1203 KKRESKFIKDADEEKAS-LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSV 1261
Query: 586 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
++ S+K ++ ++K + + + S + E A ++++ S ++D
Sbjct: 1262 VQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVD 1321
Query: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI 705
L+ +++ LK K+E + A N D N + DQ
Sbjct: 1322 LQ-----------RKNQDLK-------------MKVEMMSEAALNGNGDDLNNYDSDDQE 1357
Query: 706 KQLDKEASYYRDEC 719
KQ K+ + D C
Sbjct: 1358 KQSKKKPRLFCDIC 1371
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 135 bits (341), Expect = 1e-31
Identities = 156/792 (19%), Positives = 363/792 (45%), Gaps = 76/792 (9%)
Query: 141 QVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEE 200
+V +ST +LQ QL + ++++ + +KL + N ++ K++ ++ E
Sbjct: 472 KVTNST--ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 529
Query: 201 AARMSVLKEQMRVSHEENQHLQLTIQALQDE---LRTQRDLNHLLQQESGNRGAEHFTIE 257
A + KE + + +E + L IQA + E L ++ NH LQ++ T +
Sbjct: 530 AL-LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ-----VTQLTEK 583
Query: 258 LTEENFRRLQAE---HDRQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKKLLEM-L 312
L ++ QA+ HD+ ++ LR + + L +ET LN++ +ES +K+ ++ +
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV-LSLETSVNELNSQLNESKEKVSQLDI 642
Query: 313 QSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHR-RSQLQPEPA 371
Q K L + +T + A+ ++ + + L K++E + +L + ++LQ +
Sbjct: 643 QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 372 KTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKF 431
L++ ++ K SLE+ +LE +I+ L+A+ + +E+ ++ ++ + +
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762
Query: 432 MKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTE 491
++ + +L ++L ++ + + + L+ S + +E +K+ LT +E+ IL+ +
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKS-------EALESIKQKLTKQEEEKQILKQD 815
Query: 492 VDAL----RLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKK 547
+ L +++ EE + + +LQ + EK L E+ +KD L
Sbjct: 816 FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS------------ 863
Query: 548 IENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERD 607
K +LK+ + ++ A+ LE+ E + ++ E ++
Sbjct: 864 ------------KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 608 DRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSL 667
+E + +E ++ + LK ++N++Q +L + +++L ++ L + L
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL-------QGNINEL 964
Query: 668 EIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVD 727
+ + EQKK++ L+ +LK A + + + + Q+ Q +E + +++ Q +
Sbjct: 965 KQSSEQKKKQIEALQGELKIA--VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 728 RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA----NLKHNQQLEKKKNAQLL 783
+ E K+++++ ++ ++ T + +K +K++ +L N+ +N +L+
Sbjct: 1023 KSQETFKQLQSDFYGRESELLA----TRQDLKSVEEKLSLAQEDLISNRNQIGNQN-KLI 1077
Query: 784 EEVRRREDSMADNS--QHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLR 841
+E++ + ++ +S + Q++E AL+ ++E + L + + LAE E
Sbjct: 1078 QELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE 1137
Query: 842 IERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDR---LV 898
E K EE+ K E++ + KDA L++ + K A+++EK L
Sbjct: 1138 KEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK 1197
Query: 899 HQLKQQTQNRMK 910
Q+K++ + K
Sbjct: 1198 DQVKKEEEELKK 1209
Score = 134 bits (338), Expect = 3e-31
Identities = 177/795 (22%), Positives = 353/795 (44%), Gaps = 75/795 (9%)
Query: 149 DLQAQLKELQRENDLLRKELDIKD--SKLGSSMNSIKTFWSPELKKERVLRKEEAARMSV 206
DLQA LKE + ++ L+KEL+ + + + + T S EL+ +E
Sbjct: 94 DLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFN 153
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
+K+ + ++ L I ++ + +R L +Q+ R E E T +
Sbjct: 154 IKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV-TRLTEELNKEATVIQDLKT 212
Query: 267 QAEHDRQAKELFLLRKTLEEME-----LRIETQKQTLNARDESIKKLLEMLQSKGLPSKS 321
+ +++ +L+K L +++ + +E ++++ +DE K + S+ S+
Sbjct: 213 ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQL 272
Query: 322 LEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQ--------LQPEPAKT 373
+ + + +A ++ L+ +++ ++N L E L ++ Q E
Sbjct: 273 RSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK 332
Query: 374 KALQTVIEMKDTKIASLERNIRDLEDEIQM----LKANGVLNTEDREEEIKQIEVYKSHS 429
K +Q + KD L+ + E + L G T+ +EE+ ++E H
Sbjct: 333 KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA-TQKLKEELSEVETKYQH- 390
Query: 430 KFMKTKIDQLKQELSKKESELLALQTK--------LET---LSNQNSDCKQHIEVLKESL 478
+K + QL+Q+ +KE L LQ++ LET L + K+ ++ E L
Sbjct: 391 --LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKL 448
Query: 479 TAKEQRAAILQTEVDALRLRLEEK-------ESFLNKKTKQLQDLTEEKGTLAGEIRDMK 531
KEQ+ A LQ ++ L +L+EK + L+K +Q Q+ + + ++R+ +
Sbjct: 449 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ 508
Query: 532 DMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALS 591
+ LE R+I +KI+NL+ L+ + ++ L+ + L + A L + L
Sbjct: 509 NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ-LQ 567
Query: 592 EKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHAS 651
EK L+EQ + + + ES ++ ++L ++V +A L + ++ L+ +
Sbjct: 568 EKN---HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 652 SLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE 711
L S + K+ L+I I+ K E EA + AD LD
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEA------------AKTAQRADLQNHLDTA 672
Query: 712 ASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKH- 770
+ +D+ Q E++++ L +V + DK + ++LES H+K+ +K +L+
Sbjct: 673 QNALQDK----QQELNKITTQLDQVTAKLQDKQEHCSQLES----HLKEYKEKYLSLEQK 724
Query: 771 NQQLE---KKKNAQLLEEVRRREDSMADNSQHLQIE-ELMNALEKTRQELDATKARLAST 826
++LE KK A LE +E ++ D Q Q+ +L + ++L+ K ++ST
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 827 QQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEE 886
+ L +K L +++ + KQ EE +KQ+ +S+ + I EL+ ++ + T E
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQD--FETLSQ-ETKIQHEELN-NRIQTTVTE 840
Query: 887 VMALKREKDRLVHQL 901
+ +K EK+ L+ +L
Sbjct: 841 LQKVKMEKEALMTEL 855
Score = 132 bits (331), Expect = 2e-30
Identities = 189/880 (21%), Positives = 385/880 (43%), Gaps = 133/880 (15%)
Query: 137 SMLRQVRDSTMLDLQAQLKELQREN---DLLRKELDIKDSKLGSSMNSIKTFWSPELKKE 193
++L++ +D T L+ + + + ++N L +K+LD + +L S +++ +T L +
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ--QLQSRLSASET----SLHRI 363
Query: 194 RVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDE--------LRTQRDLNHL---L 242
V E+ LKE++ + QHL+ + LQ + L+ Q ++N L L
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423
Query: 243 QQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARD 302
+ G H ++ + + ++Q +L L LEE T L +
Sbjct: 424 LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483
Query: 303 ESIKKLLE----MLQSKGLPSKSLEDDNERT-RRMAEAESQVSHLEVILDQKEKENIHL- 356
+ K+ + + QS + ++D E+ R++ + + ++ +LE +L QK KENI L
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL-QKSKENISLL 542
Query: 357 ---REELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTE 413
RE+L+ +++Q +T L + E T L+ + L ++ LK + +
Sbjct: 543 EKEREDLY--AKIQAGEGETAVLNQLQEKNHT----LQEQVTQLTEK---LKNQSESHKQ 593
Query: 414 DREEEIKQIEVYKSHSKF-------MKTKIDQLKQEL--SKKESELLALQTKLET----- 459
+E Q++ K+H + ++T +++L +L SK++ L +Q K +T
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653
Query: 460 ----LSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK-------ESFLNK 508
+ Q +D + H++ + +L K+Q + T++D + +L++K ES L +
Sbjct: 654 AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Query: 509 KTKQLQDLTEEKGTLAGEIRDMK-DMLEVKERKINVLQKKIE------NLQEQLRDKDKQ 561
++ L ++ L G+I+ ++ D LEVK K LQ + +L+ + + KQ
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 562 LTNLKDRVKSLQTDSSNTDTALATLEEALSEKE-------RIIERLKEQRERDDRERLEE 614
L K+ V S + D AL ++++ L+++E + E L ++ + E
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 615 IESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKS-------- 666
I++ E + +K + AL EL+ + L + + + S K + K K+
Sbjct: 834 IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 667 -----------LEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQ----IKQLDKE 711
+E ++++KE LE + + +H ++ + E Q +KQ +KE
Sbjct: 894 CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 712 -------ASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKK 764
+ + + + +++ L LK +K + + K+ + + + + + +K
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
Query: 765 VANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ-IEELMNALE------------- 810
++ L++N + ++ QL + RE + Q L+ +EE ++ +
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 811 -KTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDAN 869
K QEL KA L +Q A+KE L ER K L++I + K ++EK
Sbjct: 1074 NKLIQELKTAKATL---EQDSAKKEQQLQ----ERCKALQDIQKEKSLKEKELVNEKSKL 1126
Query: 870 IALLELSASKKK---KTQEEVMALKREKDRLVHQLKQQTQ 906
+ E+ ++K K EE+ + K E + + LK Q
Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ 1166
Score = 123 bits (309), Expect = 7e-28
Identities = 143/643 (22%), Positives = 293/643 (45%), Gaps = 60/643 (9%)
Query: 139 LRQVRD-STMLDLQAQ--LKELQRENDLLRK-ELDIKDSKLGSSMNSIKTFWSPELKKER 194
L+Q R +T L+L+A K+L+ E +++ LD++ K ++ SIK + + ++++
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ--KKSEALESIKQKLTKQEEEKQ 810
Query: 195 VLRKEEAARMSVLKEQMRVSHEE-NQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEH 253
+L+++ L ++ ++ HEE N +Q T+ LQ + + + L+ + S +
Sbjct: 811 ILKQD----FETLSQETKIQHEELNNRIQTTVTELQ---KVKMEKEALMTELSTVKDKLS 863
Query: 254 FTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ 313
+ + + + E+ + + L KT +E++ +++ Q + + +KK LE
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE--- 920
Query: 314 SKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKT 373
K E ++ + + Q+ + L Q EKE L+ ++ Q + K
Sbjct: 921 ------KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974
Query: 374 -KALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFM 432
+ALQ + KIA L++ + + + Q+ +A L E + + Q KS F
Sbjct: 975 IEALQG-----ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029
Query: 433 KTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEV 492
QL+ + +ESELLA + L+++ + S ++ + + + + + L+T
Sbjct: 1030 -----QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAK 1084
Query: 493 DALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDML----EVKERKINVLQKKI 548
L +KE L ++ K LQD+ +EK E+ + K L E+K R+ + K
Sbjct: 1085 ATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN 1144
Query: 549 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDD 608
E L+ + K++TNLKD + L +L+ A+ +++R + LK+Q ++++
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 609 RERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLE 668
E K+ EK L +E+ EKE + +K+H + A K ++ +L
Sbjct: 1205 EEL----------KKEFIEKEAKLHSEIKEKE---VGMKKHEENEA----KLTMQITALN 1247
Query: 669 IAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDK-EASYYRDECGKAQAEVD 727
+ K+E + ++ + DD R + Q ++ E + C K + E++
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307
Query: 728 RL----LEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA 766
+L LE+ ++++N + E +SL ++H + N+K A
Sbjct: 1308 KLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWA 1350
Score = 114 bits (285), Expect = 4e-25
Identities = 157/737 (21%), Positives = 320/737 (43%), Gaps = 87/737 (11%)
Query: 114 VLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKE-LDIKD 172
+ + DQ H Q+ S L++ ++ L L+ + +EL+ + L + L++K
Sbjct: 686 ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK-YLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 173 SKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDEL 232
SK + +L+++R L + R + L +Q+ + E +L +Q + L
Sbjct: 745 SKEQALQ---------DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 233 RTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELF-LLRKTLEEMELRI 291
+ + L +QE ++ +++F L E Q +EL ++ T+ E++ ++
Sbjct: 796 ESIKQ--KLTKQEEEK--------QILKQDFETLSQETKIQHEELNNRIQTTVTELQ-KV 844
Query: 292 ETQKQTLNARDESIKKLLEMLQSKGLPSKS-LEDDNERTRR-MAEAESQVSHLEVILDQK 349
+ +K+ L ++K L + SKS E +N++ + + + E L+ L Q
Sbjct: 845 KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL-QV 903
Query: 350 EKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGV 409
+ EN L+E+ + L+ E + L+ + ++ + ++ E E Q L+ N
Sbjct: 904 QMENT-LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNIN 962
Query: 410 LNTEDREEEIKQIEVYKSHSKF---MKTKID-QLKQELSKKESELLALQTKLETLSNQNS 465
+ E++ KQIE + K KT+++ +L+Q+L++ EL A + K+ L N
Sbjct: 963 ELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 466 DCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAG 525
++ + L+ +E + ++ ++ EEK S + ++ + L
Sbjct: 1023 KSQETFKQLQSDFYGRESELLATRQDLKSV----EEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 526 EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALAT 585
E++ K LE K ++QL+++ K L +++ + + N + LA
Sbjct: 1079 ELKTAKATLEQDSAK----------KEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE 1128
Query: 586 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
+EE +E+ I +L E+ + E ++EI + KD K+ + + EL K SL
Sbjct: 1129 IEEIKCRQEKEITKLNEELKSHKLESIKEITNL----KDAKQLLIQQKLELQGKADSL-- 1182
Query: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI 705
A ++++ + + + K++ K E +LKK IE +++++ E I
Sbjct: 1183 ---------KAAVEQEKRNQQI------LKDQVKKEEEELKKEF-IEKEAKLHSE----I 1222
Query: 706 KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKV 765
K+ + + + K ++ L E L V+ E ++++ELE T D ++
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQT----DDLRGEI 1278
Query: 766 ANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKA---R 822
A L+ Q + + LLE + E +IE+L + + +++LD T A
Sbjct: 1279 AVLEATVQNNQDERRALLERCLKGEG---------EIEKLQTKVLELQRKLDNTTAAVQE 1329
Query: 823 LASTQQSLAEKEAHLAN 839
L QSL K N
Sbjct: 1330 LGRENQSLQIKHTQALN 1346
Score = 113 bits (282), Expect = 1e-24
Identities = 158/704 (22%), Positives = 301/704 (42%), Gaps = 73/704 (10%)
Query: 229 QDELRTQRDLNHLLQQESGNRGA----EHFTIELTEENFRRLQAEHDRQAKELFLLRKTL 284
+ L +RD LL+QE + A E + E ++ + Q ++AK L+ +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 285 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLP-SKSLED-----DNERTRRMAEAESQ 338
E++ +E Q + + +IK++ ++ + K + + D D ER+ R A AE +
Sbjct: 135 AELQ-SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA-AEQK 192
Query: 339 VSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398
V+ L L+++ L+ EL +R ++ K L V + D ER L+
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 252
Query: 399 DEIQMLKANGVLN----TEDREEEIK---QIEVYKSHSKFMKTKIDQLKQELSKKESELL 451
DE + L++ + ++ R E K ++ VY + +K+ +++L Q+ LL
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312
Query: 452 ALQ---TKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNK 508
+ TKLE N+ S K++I+ +L K+ LQ+ + A L L++
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQA---TLHQKDLDCQQLQSRLSASETSLHRIHVELSE 369
Query: 509 KTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDR 568
K + Q L EE L E K L+ + + LQ+Q +K++ L+
Sbjct: 370 KGEATQKLKEE--------------LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 569 VKSLQTDSSNTDTALATLEEALSEKERI-IERL--KEQRERDDRERLEEIESFRKE---- 621
+ L + T+ L L E+ ++ E+L KEQ+ D + +L +E KE
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 622 NKDLKEKVNALQAELTE----KESSLIDLKEHASSLASAGLK---RDSKLKSLEIAIEQK 674
+ +L+ +++ + + E ++S+ L+E + L + +D K+++LE +++
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 675 KEECSKLEAQLKKAHN-----------IEDDSRMNPEFADQIKQLDKEASYYRDECGKAQ 723
KE S LE + + + + N +Q+ QL ++ + +AQ
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 724 AEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLL 783
+ L + ++E + ++ LE+ N+ + K K LL
Sbjct: 596 ---ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652
Query: 784 EEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIE 843
+ AD HL + NAL+ +QEL+ +L L +K+ H + L
Sbjct: 653 SAEAAKTAQRADLQNHL--DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESH 710
Query: 844 RRKQLEEI--LEMKQEALLAAISEKDANIALLELSASKKKKTQE 885
++ E+ LE K E L I + +A+ LE+ ASK++ Q+
Sbjct: 711 LKEYKEKYLSLEQKTEELEGQIKKLEAD--SLEVKASKEQALQD 752
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 135 bits (339), Expect = 2e-31
Identities = 178/788 (22%), Positives = 335/788 (42%), Gaps = 74/788 (9%)
Query: 145 STMLDLQAQLKELQRENDLLRKELDIKD--SKLGSSMNSIKTFWSPELKKERVLRKEEAA 202
S +++L+ L +E LR+ L+ + S++ ++ S + K E V R +
Sbjct: 464 SRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE-VTRTDHQR 522
Query: 203 RMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHF-TIELTEE 261
++ LKE E +Q I+AL N L+ + + E+ I L +
Sbjct: 523 EITSLKEHFGAREETHQK---EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKS 579
Query: 262 NFRRLQAEHDRQAKELF------LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 315
A H + +EL L +T E EL+ + +K L+ + E + L+ Q
Sbjct: 580 KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI--ENLQNQQDS 637
Query: 316 GLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEK-ENIHLREELHRRSQLQPEPAKTK 374
+ + E + R + M + + + LE I + +K E+ HL E ++LQ K K
Sbjct: 638 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697
Query: 375 ALQT----------VIEMKDTKIASLERNIRDL--------EDEIQMLKANGVLNTEDRE 416
L+ VI+ +++ + E + DL E + +M K L E E
Sbjct: 698 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQL--EAAE 755
Query: 417 EEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE 476
++IK +E+ K+ +K + +EL +E +L LQ L +S ++ +++LKE
Sbjct: 756 KQIKHLEIEKNAES---SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 812
Query: 477 SLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEV 536
+ A +Q + +L +KE N + L+ L E + + R+ + E
Sbjct: 813 KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQ 872
Query: 537 KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI 596
+ L+ I + + D QLT + D ++ + D L E S ++
Sbjct: 873 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKS 932
Query: 597 IERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASA 656
IE + + E+ +E ++ E +E K+L+ K++ L+ ++ + +LK S
Sbjct: 933 IEDMTVKAEQSQQEAAKKHE---EEKKELERKLSDLEKKMETSHNQCQELKARYERATS- 988
Query: 657 GLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYR 716
++K K EI ++ ++ E +LK A E++S + E + KQ DK
Sbjct: 989 ----ETKTKHEEI-LQNLQKTLLDTEDKLKGAR--EENSGLLQELEELRKQADK------ 1035
Query: 717 DECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNK----KVANLKHNQ 772
KA + ++I++++ EK + +A LE + K QN+ K NLK+ +
Sbjct: 1036 ---AKAAQTAEDAMQIMEQMTKEKTE---TLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
Query: 773 QLEKKKNA-----QLLEEVRRREDSM--ADNSQHLQIEELMNALEKTRQELDATKARLAS 825
+L K K Q +EE R+ +++ A + Q+ L K +EL ++ + S
Sbjct: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS 1149
Query: 826 TQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQE 885
Q L E+ + L N +E +K+ + ++ E + ALL ++ +K +
Sbjct: 1150 -HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1208
Query: 886 EVMALKRE 893
EV L+ E
Sbjct: 1209 EVTVLRGE 1216
Score = 127 bits (320), Expect = 4e-29
Identities = 199/916 (21%), Positives = 398/916 (43%), Gaps = 114/916 (12%)
Query: 56 YATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVL 115
Y P++ G STT K R A + S+ +++S + V
Sbjct: 269 YGLFAPVHKVTKIGFPSTTPAKAKANAVRRV-MATTSASLKRSPSASSLSSMSSVASSVS 327
Query: 116 SYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKL 175
S + G LT +S + ++ S LQ LKE Q+ + L E D++ +++
Sbjct: 328 SRPSRTGLLTETSSRYARKI---------SGTTALQEALKEKQQHIEQLLAERDLERAEV 378
Query: 176 GSSMNSIKTFWSPELKKERVLRK--------EEAARMSVLKEQMRVSHEENQHLQLTIQA 227
+ + + E+++E L + E A+M L+ + + E L +
Sbjct: 379 AKATSHVG-----EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVEL---LNQ 430
Query: 228 LQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM 287
L++E R DL +++ES +G + E R ++ E K+L L + + E+
Sbjct: 431 LEEEKRKVEDLQFRVEEESITKG--DLEVATVSEKSRIMELE-----KDLALRVQEVAEL 483
Query: 288 ELRIETQKQTLNARDESIKKLLEM--LQSKGLPSKSLEDDNERT-------RRMAEAESQ 338
R+E+ K + D S+ L E+ LQ K L + E T R + +
Sbjct: 484 RRRLESNKPAGDV-DMSLSLLQEISSLQEK-LEVTRTDHQREITSLKEHFGAREETHQKE 541
Query: 339 VSHLEVILDQKEKENIHLREEL-HRRSQLQPEPAKTKA-LQTVI-----EMKDTKIASLE 391
+ L ++ KEN L+ +L H + A K+ L+T I M++ K+ S
Sbjct: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV-SFS 600
Query: 392 RNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYK-----SHSKFMKTKIDQLKQELSKK 446
+ + E LK D + EI+ ++ + +H+K M+ +L + + +K
Sbjct: 601 KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
Query: 447 ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 506
E+ L A+++KL+ + QH+ ++++L K Q A I E++ L+ + E+ +
Sbjct: 661 ENSLEAIRSKLDKAED------QHLVEMEDTLN-KLQEAEIKVKELEVLQAKCNEQTKVI 713
Query: 507 NKKTKQLQDLTEEK-----------GTLAGEIRDMKDMLEVKERKI-------NVLQKKI 548
+ T QL+ TEEK E++ ++ LE E++I N K
Sbjct: 714 DNFTSQLK-ATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 772
Query: 549 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL---SEKERIIERLKEQRE 605
++ +L+ ++ +LTNL++ + + + L L+E SE+ ++R ++
Sbjct: 773 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 832
Query: 606 RDDRERLEEIESFRKENKDLKEKVNALQAELTEK---ESSLIDLKEHASSLASAGLK--- 659
++ E+ + + L+E + ++A+ EK E LI KE + + +K
Sbjct: 833 NKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG 892
Query: 660 -RDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDE 718
S+L + + K+ + +L+ +L KA+ E+ S + D + ++ +
Sbjct: 893 DNSSQLTKMNDELRLKERDVEELQLKLTKAN--ENASFLQKSIEDMTVKAEQSQQEAAKK 950
Query: 719 CGKAQAEVDR-LLEILKEVENEKNDKDKKIAELESLT----LRH---MKDQNKKVANLKH 770
+ + E++R L ++ K++E N + A E T +H +++ K + + +
Sbjct: 951 HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1010
Query: 771 NQQLEKKKNAQLLEEVRRREDSMADNSQHLQ-IEELMNALEKTRQELDATKARLASTQQS 829
+ +++N+ LL+E+ AD ++ Q E+ M +E+ +E T A L T+Q+
Sbjct: 1011 KLKGAREENSGLLQELEELR-KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1069
Query: 830 LAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEK----DANIALLELSASKKKKTQE 885
A+ + L L+ K +EE+ + K+ LL ++K I L+ +A++K +
Sbjct: 1070 NAKLQNELDTLKENNLKNVEELNKSKE--LLTVENQKMEEFRKEIETLKQAAAQK---SQ 1124
Query: 886 EVMALKREKDRLVHQL 901
++ AL+ E +L +L
Sbjct: 1125 QLSALQEENVKLAEEL 1140
Score = 99.0 bits (245), Expect = 2e-20
Identities = 131/614 (21%), Positives = 261/614 (42%), Gaps = 92/614 (14%)
Query: 141 QVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLG-SSMNSIKTFWSPELKKERVLRKE 199
Q R+ + +LQ L E+ + + L KEL I K +S ++ S + ++ +KE
Sbjct: 780 QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKE 839
Query: 200 EAARM-SVLKEQMRVS--------HEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRG 250
E M S E++R + E+++ + I+A + + + D+ +++ N
Sbjct: 840 EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE---KLENDIAEIMKMSGDNSS 896
Query: 251 A---EHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKK 307
+ + L E + LQ + + + L+K++E+M ++ E +Q + E KK
Sbjct: 897 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956
Query: 308 LLEM----LQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVI-------LDQKEK----- 351
LE L+ K S + + + A +E++ H E++ LD ++K
Sbjct: 957 ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR 1016
Query: 352 -ENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVL 410
EN L +EL +L+ + K KA QT ED +Q+++
Sbjct: 1017 EENSGLLQELE---ELRKQADKAKAAQTA------------------EDAMQIMEQM--- 1052
Query: 411 NTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQH 470
T+++ E + +E K + ++ ++D LK+ K EL + L + + + ++
Sbjct: 1053 -TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 1111
Query: 471 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM 530
IE LK++ K Q+ + LQ E ++L E+ + Q L EE+ L ++ +M
Sbjct: 1112 IETLKQAAAQKSQQLSALQEE----NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1167
Query: 531 KD-----MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALAT 585
K + + E K + LQK I L +KD +L L++ V L+ ++++ + +
Sbjct: 1168 KKRESKFIKDADEEKAS-LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSV 1226
Query: 586 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
++ S+K ++ ++K + + + S + E A ++++ S ++D
Sbjct: 1227 VQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVD 1286
Query: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI 705
L+ +++ LK K+E + A N D N + DQ
Sbjct: 1287 LQ-----------RKNQDLK-------------MKVEMMSEAALNGNGDDLNNYDSDDQE 1322
Query: 706 KQLDKEASYYRDEC 719
KQ K+ + D C
Sbjct: 1323 KQSKKKPRLFCDIC 1336
Score = 48.5 bits (114), Expect = 3e-05
Identities = 68/349 (19%), Positives = 148/349 (42%), Gaps = 35/349 (10%)
Query: 586 LEEALSEKERIIERLKEQRERDDRE---------RLEEIESFRKENKDLKEKVNALQAEL 636
L+EAL EK++ IE+L +R+ + E +E+ + ++ D + V L+A++
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD--QHVLELEAKM 410
Query: 637 TEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSR 696
+ + + L + + K++ L+ +E++ LE + + SR
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVA-----TVSEKSR 465
Query: 697 MNPEFADQIKQLDKEASYYRD-ECGKAQAEVDRLLEILKEV-------ENEKNDKDKKIA 748
+ D ++ + A R E K +VD L +L+E+ E + D ++I
Sbjct: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 525
Query: 749 ELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQI--EELM 806
L+ + K++ L + K+N L ++ E + +NS + + +L
Sbjct: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL---EHANKENSDVIALWKSKLE 582
Query: 807 NALEKTRQELDATKAR----LASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAA 862
A+ +Q ++ K L + AE + + +R++ + ++E + + A
Sbjct: 583 TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH 642
Query: 863 ISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLK-QQTQNRMK 910
E +A A L + K+K+ E + K +K H ++ + T N+++
Sbjct: 643 AKEMEALRAKL-MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ 690
>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
Length = 1113
Score = 134 bits (336), Expect = 5e-31
Identities = 187/871 (21%), Positives = 374/871 (42%), Gaps = 134/871 (15%)
Query: 131 HHHQVPSMLRQVRDS-------------TMLDLQAQLKELQRENDLL----RKELDIKDS 173
+ HQV + R++ +S +++DLQ +L+E+Q E D + R+E ++
Sbjct: 83 YSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQED 142
Query: 174 KLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELR 233
N++ + + KE +L K+ ++ L++ M +SHE L+
Sbjct: 143 LRNQLQNTVHELEAAKCLKEDML-KDSNTQIEQLRKMM-LSHE-------------GVLQ 187
Query: 234 TQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIET 293
R + ++ SG + EH + ++ +FR L + + +EL L+ +E
Sbjct: 188 EIRSILVDFEEASGKKICEHDS--MSTLHFRSLGSAISKILRELDTEISYLKGRIFPVED 245
Query: 294 QKQTLNARDES-IKKLLEMLQSK--GLPSKSLEDDNERTRRMAEAESQV----SHLEVIL 346
Q + L + ++ I+ LL+ Q + L S+ + T + + A SQ S +E+I
Sbjct: 246 QLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQ 305
Query: 347 DQKEKEN--------------IHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLER 392
+Q +N LR EL ++ + + Q V+ + A ER
Sbjct: 306 EQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTER 365
Query: 393 N-----IRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFM-------KTKIDQLK 440
+ +L+D++Q L A D + K++ + K +K + ID L+
Sbjct: 366 DQFSQESGNLDDQLQKLLA-------DLHKREKELSLEKEQNKRLWDRDTGNSITIDHLR 418
Query: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 500
+EL + E+ L+ L+ L S+C+ +E ++ K + +V +L +LE
Sbjct: 419 RELDNRNMEVQRLEALLKAL---KSECQGQMERQMAAIQGKNESL----EKVSSLTAQLE 471
Query: 501 EKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDM---LEVKERKINVLQKKIENLQEQLRD 557
+ L K +++LT +K TL R + D+ L+ KER I +I L+ ++
Sbjct: 472 STKEMLR---KVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDL 528
Query: 558 KDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRE------------ 605
K ++L +LK+ L+ N T L+ ++EK+++IE L++Q E
Sbjct: 529 KLQELQHLKNEGDHLR----NVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRT 584
Query: 606 ----RDDRERLE-EIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR 660
+ ++ +LE EI R E K+LK + A++ E E+ + DL+ L +AG +R
Sbjct: 585 AGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSER 644
Query: 661 DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
+K ++ +Q E ++L E+ + F ++ ++++ + + +
Sbjct: 645 LRAVKDIKQERDQLLNEVKTSRSELNNLS--EEYEVLKRNFRNKSEEMEMTTNKLKMQLK 702
Query: 721 KAQAEVDRLLEILKEVENEKNDKDK-----------KIAELESL--TLRHMKDQNKKVAN 767
AQ+E+++ LK +E K K ++++L ++ +++
Sbjct: 703 SAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANK 762
Query: 768 LKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQE--LDATKARLAS 825
KH + EK K +Q L V ++ MA + L+ +E + T E LD + A
Sbjct: 763 EKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAE 822
Query: 826 TQQSLAEKEAHLANLRIERRKQLEEI--------LEMKQEALL-AAISEKDANIALLELS 876
Q + +E L+++ ++E+ +K L A+++ +N+ + +
Sbjct: 823 CQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQST 882
Query: 877 ASKKKKTQEEVMALKREKDRLVHQLKQQTQN 907
AS + LK + R + QL Q+ ++
Sbjct: 883 ASFLSHHSTKANTLKEDPTRDLKQLLQELRS 913
Score = 114 bits (286), Expect = 3e-25
Identities = 167/774 (21%), Positives = 323/774 (41%), Gaps = 141/774 (18%)
Query: 250 GAEHFTIELTEENF------RRLQAEHDRQAKELFLLRKT-------LEEMELRIETQKQ 296
G EHF L E + RRL ++ K+ F LR++ L+EM++ +
Sbjct: 72 GKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMAD 131
Query: 297 TLNARDESIKKLLEMLQS--------KGLPSKSLEDDN---ERTRRMAEAESQVSH--LE 343
+S + L LQ+ K L L+D N E+ R+M + V
Sbjct: 132 IRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRS 191
Query: 344 VILDQKEKENIHLREE-----LHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398
+++D +E + E LH RS A+ ++ DT+I+ L+ I +E
Sbjct: 192 ILVDFEEASGKKICEHDSMSTLHFRSL-------GSAISKILRELDTEISYLKGRIFPVE 244
Query: 399 DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE 458
D+++ LK+ E +IE+ ++ D+++Q +S+ E E+ L K
Sbjct: 245 DQLEALKS----------ESQNKIEL------LLQQHQDRIEQLISEHEVEITGLTEKAS 288
Query: 459 TLSNQNSDCKQHIEVLKESLTAKE----QRAAILQTEVDALRLRLEEKESFLNKKTKQLQ 514
+ +Q + + +E+++E + ++ + L++ V LR L E + KT++L+
Sbjct: 289 SARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELE 348
Query: 515 DLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQT 574
+ E R +D ++ L +++ L L ++K+L+ K++ K L
Sbjct: 349 KQLVLANSELTEARTERDQF---SQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWD 405
Query: 575 DSSNTDTALATLEEALSEKERIIERLKE-----------QRERD------DRERLEEIES 617
+ + L L + ++RL+ Q ER E LE++ S
Sbjct: 406 RDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSS 465
Query: 618 FRKENKDLKEKVNALQAELTEKESSL-------------IDLKEHASSLASAGLKR---- 660
+ + KE + + ELT K+ +L + KE A +A + +
Sbjct: 466 LTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSR 525
Query: 661 -DSKLKSLEIA------IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQ-IKQLDKEA 712
D KL+ L+ + + EC L+ Q+ + + + R E Q + Q + A
Sbjct: 526 VDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTA 585
Query: 713 SYYRDECGKAQAEV-DRLLEILKEVENEKNDKDKKIAELES----LTLRHMKDQNKKVAN 767
+ E + + E+ DR +E LKE++ K+ KD KI ELE+ L L +K N
Sbjct: 586 GAMQVEKAQLEKEINDRRME-LKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSER 644
Query: 768 LKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQI---------EELMNALEKTRQELDA 818
L+ + ++++++ QLL EV+ + + S+ ++ EE+ K + +L +
Sbjct: 645 LRAVKDIKQERD-QLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKS 703
Query: 819 TKARLASTQQSLAEKE---AHLANLRIERRKQ----------LEEILEMKQEALLAAISE 865
++ L T+ +L E H + + +KQ L+ ++ +EA+ A E
Sbjct: 704 AQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKE 763
Query: 866 KDANIALLELSASKKKKTQEEVMALKREKDRLVHQLK--QQTQNRMKLMADNYD 917
K +K K +E+ + EK+++ +L+ + + R+K N +
Sbjct: 764 K-------HFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNME 810
Score = 88.2 bits (217), Expect = 3e-17
Identities = 160/855 (18%), Positives = 350/855 (40%), Gaps = 164/855 (19%)
Query: 139 LRQVRD--STMLDLQAQLKELQR----ENDLLRKELDIKDSKLGSSMNSIKTFWSP---- 188
+RQ+ D ST+ L+++L+E +R + + L K+L + +S+L + F
Sbjct: 316 MRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNL 375
Query: 189 ------------ELKKERVLRKEEAARM-----------SVLKEQMRVSHEENQHLQLTI 225
+ +KE L KE+ R+ L+ ++ + E Q L+ +
Sbjct: 376 DDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALL 435
Query: 226 QALQDELRTQRDLNHLLQQESGNRGAEHFT-----IELTEENFRRLQAEHDRQAKELFLL 280
+AL+ E + Q + + + N E + +E T+E R++ E + L
Sbjct: 436 KALKSECQGQME-RQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS 494
Query: 281 RKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVS 340
+T+ ++ ++ +++ + A + I KL + K + L+++ + R + +++
Sbjct: 495 ERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNV---QTECE 551
Query: 341 HLEVILDQKEKENIHLREELHRRSQLQPEPAKT----------------------KALQT 378
L++ + +K+K LR+++ +QL + +T K L+
Sbjct: 552 ALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI 611
Query: 379 VIEMKDTKIASLERNIRDLE-DEIQMLKANGVLNT------EDREEEIKQIEV------- 424
+ + KD KI LE + DLE ++++++ A ++R++ + +++
Sbjct: 612 LKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNN 671
Query: 425 -----------YKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEV 473
+++ S+ M+ ++LK +L +SEL + L+++ + +
Sbjct: 672 LSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMG 731
Query: 474 LKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDM 533
+++ +TAK + ++DAL+ +++ E + K+ L EEK L+ E
Sbjct: 732 MQKQITAK-------RGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQE------- 777
Query: 534 LEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEK 593
L + N + ++E L+ Q R LK++V +++ A ++ + +
Sbjct: 778 LSTVATEKNKMAGELEVLRSQER-------RLKEKVTNMEVALDKASLQFAECQDIIQRQ 830
Query: 594 ERIIERLKEQRERDDRERLEEIES-FRKENKDLKEKVNALQAELTEKESSLIDLKEHASS 652
E+ RLK Q D ++E++ N LK ++ A +T S++ + AS
Sbjct: 831 EQESVRLKLQHTLD----IKELQGPGYTSNSSLKPRL-LQPASVTRSHSNVPSSQSTASF 885
Query: 653 LASAGLKRDSKLKSLEIAIEQKKEECSKL--EAQLKKAHNIEDDSRMN-PEFADQIKQLD 709
L+ K ++ + ++Q +E + E E+D R + D+++
Sbjct: 886 LSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCI 945
Query: 710 KEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQN------- 762
E+S D C ++ + ++ + K + E +TL H D+
Sbjct: 946 TESSLRSDMCHRSNNSLR---------DSTEGSKSSETLSREPVTL-HAGDREDPSGCFT 995
Query: 763 ---------KKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTR 813
K A+ N +K LL E S+ SQ+ + + ++
Sbjct: 996 FTSAASPSVKNSASRSFNSSPKKSPVHSLL--TSSVEGSIGSTSQYRSAKPIHSS----- 1048
Query: 814 QELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALL 873
D+ K + ++ + L N R+E + L E L++K +A+ + I ++ I
Sbjct: 1049 ---DSVKDSQSPPIETTGKTCRKLQN-RLESLQTLVEDLQLKNQAMSSMIRNQEKRI--- 1101
Query: 874 ELSASKKKKTQEEVM 888
+K K QE+++
Sbjct: 1102 -----QKVKDQEKML 1111
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 134 bits (336), Expect = 5e-31
Identities = 176/835 (21%), Positives = 369/835 (44%), Gaps = 67/835 (8%)
Query: 134 QVPSMLRQVRDSTMLDLQAQLKELQRENDLL----RKELDIKDSKLGSSMNSIKTFWSPE 189
Q + L+Q+ +S + + + QLK +EN + ++EL + +L + +
Sbjct: 1050 QEKNELQQMLESVIAEKE-QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
Query: 190 LKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDEL-RTQRDLNHL--LQQES 246
+KKE L + R++ ++E+++ ++ Q Q + +Q+E+ Q+ +N + L+ E
Sbjct: 1109 IKKEGELSRT-CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNEL 1167
Query: 247 GNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIK 306
N+ +E + E+ + K + RK L+E++ ET++ L I+
Sbjct: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227
Query: 307 KL-LEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREE---LHR 362
L+ + + L++ E + + S+ + + EK + L+EE LH
Sbjct: 1228 ATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287
Query: 363 RSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLED----EIQMLKANGVLNTEDREEE 418
+L P + Q M + ++ + + +D E++ L+ N ++ +EE
Sbjct: 1288 EQELLPNVKEVSETQET--MNELELLTEQSTTKDSTTLARIEMERLRLNEKF--QESQEE 1343
Query: 419 IKQIEVYKSHSKFMK----TKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVL 474
IK + + + K +K K DQLK+ + + +++ Q+K E N + +++
Sbjct: 1344 IKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIV 1403
Query: 475 KESLTAKEQRAAILQTEVDALRL--RLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 532
E K + +A+L+ E++ L L RL+E + K+ DL + L E +K+
Sbjct: 1404 SEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKE 1463
Query: 533 MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLE---EA 589
+KE ++ K +E +E+L+ L ++ + L+ + S +T ++T++ EA
Sbjct: 1464 --NIKE----IVAKHLET-EEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEA 1516
Query: 590 LSEK-ERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLK- 647
+++K + I+ + E+ E+ + +++ E++ E K KE A + L ES +++L
Sbjct: 1517 INDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTN 1576
Query: 648 --EHASSLASAGLKRDSKLK----SLEIAIEQKKEECSKLEAQLKKAHNIE------DDS 695
+ + +K ++K +L+I +Q KE ++ A++K++ E
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV 1636
Query: 696 RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESL-- 753
E +I+ L ++ + + E RL +IL E E K+ +L S+
Sbjct: 1637 NETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696
Query: 754 TLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIE---ELMNALE 810
TL+ +DQ K+ + LEK++ +++ + D + + E E+ N +
Sbjct: 1697 TLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK 1756
Query: 811 KTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANI 870
DA KA+ Q+ L HL + E +L I+ K + L + + +
Sbjct: 1757 DLEHSNDALKAQDLKIQEELRIAHMHLKEQQ-ETIDKLRGIVSEKTDKLSNMQKDLENSN 1815
Query: 871 ALLELSASKKKKTQEEVMALKR----------EKDRLVHQLKQQTQNRMKLMADN 915
A L+ + K + +++ LK+ E ++L Q+K Q+ KL +N
Sbjct: 1816 AKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870
Score = 126 bits (317), Expect = 8e-29
Identities = 169/838 (20%), Positives = 368/838 (43%), Gaps = 88/838 (10%)
Query: 144 DSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAAR 203
+S + L+A L + + LR E + + KL N + F + E K ++ +
Sbjct: 497 ESELNSLRADYDNLVLDYEQLRTEKEEMELKL-KEKNDLDEFEALERKTKKDQEMQLIHE 555
Query: 204 MSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEH------FTIE 257
+S LK ++ + NQ L+ + + + LR + D LQ+ ++ E+ +++E
Sbjct: 556 ISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLE 615
Query: 258 LTEENFRRLQAEHDRQAKELFLLRKT--LEEMELRIETQKQTLNARDESIKKLLEMLQSK 315
E+ + Q D + L R++ L L ++ + + L + ++ +++ QS+
Sbjct: 616 SIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQ 675
Query: 316 GLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRR-----SQLQPEP 370
K ++ D E+ + A ++++ L ++D K +++ EL + +L E
Sbjct: 676 LEAKKKMQVDLEK--ELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEV 733
Query: 371 AKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSK 430
+ +AL+ + + +++ SL + L EIQ + T ++++ ++ +S +
Sbjct: 734 EENEALREEVILL-SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQ 792
Query: 431 FMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQT 490
+ +I + K +L+ +S + + + + D +Q +++ E Q L
Sbjct: 793 GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK 852
Query: 491 EVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKK--- 547
E L ++ L+ KT++LQ+ T E E+ +K+ LE ++ + ++++
Sbjct: 853 EAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTL 912
Query: 548 -IENLQEQLRDKDKQLTNLKDRVKSLQ----------------TDSSNTDT--ALATLEE 588
E LQ+ L ++ K LT KD +K LQ T + N DT L E
Sbjct: 913 ITEKLQQTL-EEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 589 ALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKV------NALQAELTE---- 638
+L + + I LK + + L E+ + + ++K+ L+A+ T+
Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031
Query: 639 --KESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSR 696
K++ +I+ + SL +++ + LE I +K++ + L+ ++ +++ R
Sbjct: 1032 DVKDNEIIEQQRKIFSLIQ---EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR 1088
Query: 697 MNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTL- 755
+ D++K+ + + ++ K + E+ R + L EVE + +K +++ E + L
Sbjct: 1089 L---LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN 1145
Query: 756 --RHMKDQNKK---VANLKH----------NQQLEKKKNAQLLEEVRRREDSMADNSQHL 800
M + KK + NLK+ + + E+ + AQ L E E+ + +
Sbjct: 1146 VQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE--NYEEVKSITKERK 1203
Query: 801 QIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALL 860
++EL + E R L + +T E E +A++ ++ + E I E+++
Sbjct: 1204 VLKELQKSFETERDHLRGYIREIEATGLQTKE-ELKIAHIHLKEHQ--ETIDELRR---- 1256
Query: 861 AAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLK----QQTQNRMKLMAD 914
++SEK A I + K QEE+ L E++ L + + Q+T N ++L+ +
Sbjct: 1257 -SVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTE 1313
Score = 124 bits (310), Expect = 5e-28
Identities = 177/848 (20%), Positives = 370/848 (43%), Gaps = 126/848 (14%)
Query: 153 QLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLK-EQM 211
QL +L E DLL+K +++ K+ + + T S L++E +++ + K +M
Sbjct: 375 QLAQLLEEKDLLQK---VQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKM 431
Query: 212 RVSHEENQH---LQLTIQALQDELRTQRDLNHLLQQESG--------------NRGAEHF 254
+ S+ +Q +T + + + R+++ + ES N +
Sbjct: 432 KNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLL 491
Query: 255 TIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQK--------QTLNARDESIK 306
E E L+A++D + LR EEMEL+++ + + +D+ ++
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ 551
Query: 307 KLLEMLQSKGLP------SKSLEDD-NERTRRMAEAESQVSHLEVILDQKEKENIHLREE 359
+ E+ K L ++ LE++ + + + E E Q+ L+ +D ++ ENI +
Sbjct: 552 LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS 611
Query: 360 LHRRSQLQPE-------PAKTKALQTV----------IEMKDTKIASLERNIRDLEDEIQ 402
S P+ A+T AL +E+K+ K+ L + +E++IQ
Sbjct: 612 YSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKE-KMKELATTYKQMENDIQ 670
Query: 403 M----LKANGVLNTEDREEEIKQI--EVYKSHSKF-------------MKTKIDQLKQEL 443
+ L+A + D E+E++ E+ K S ++ KI L++EL
Sbjct: 671 LYQSQLEAKKKMQV-DLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKEL 729
Query: 444 SKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 503
+K+ E AL+ ++ LS S +E L++ + K + I+ +E D L + KE
Sbjct: 730 NKEVEENEALREEVILLSELKS-LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKE 788
Query: 504 SFLNKKTKQLQDLTEEKGTLAG-------EIRDMKDMLEVKERKINVLQKKIENLQEQLR 556
S + +++ ++ T E ++ K + E+K ++ ++ E + +++
Sbjct: 789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIV 848
Query: 557 DKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDD-------- 608
+ K+ + +L+T+ S L + E+ +E+LKEQ E D
Sbjct: 849 NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER 908
Query: 609 ---------RERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLK 659
++ LEE+++ +E DLK+ +LQ E + +S + D + +
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHD-------TVNMNID 961
Query: 660 RDSKLKSLEIAIEQKKEECSKLEAQL-----KKAHNIEDDSRMNPEFADQIKQLDKEASY 714
+L++ +++Q +E + L++++ + H E+ EF ++ +DK+
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021
Query: 715 YRDECGKAQAEV--DRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN- 771
A+V + ++E +++ + +K++ LES+ K+Q K +LK N
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAE--KEQLK--TDLKENI 1077
Query: 772 -QQLEKKKNAQLL-EEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQS 829
+E ++ +LL +E++++++ +A H +E L +T L + +L Q
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE--GELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 830 LAEKEAHLANLR---IERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEE 886
L EK+ L N++ E +K++ EI +K E ++ + LEL A K + EE
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL-AQKLNENYEE 1194
Query: 887 VMALKREK 894
V ++ +E+
Sbjct: 1195 VKSITKER 1202
Score = 96.3 bits (238), Expect = 1e-19
Identities = 158/828 (19%), Positives = 346/828 (41%), Gaps = 103/828 (12%)
Query: 132 HHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKE----------LDIKDSKLGSSMNS 181
H + Q +S ML+L +L+E Q E ++ KE L I+ +L +
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE 1615
Query: 182 IKTFWSPELKKERVLRK--------EEAARMSVLKEQ-----MRVSHEENQHLQLTIQAL 228
I +KE K E+ + LKEQ + + + E ++++LT Q L
Sbjct: 1616 IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT-QIL 1674
Query: 229 QDELRTQRDLNHLLQQESGNRGAEHFTIELTE--ENFRRLQAEHDRQAKELFLLRKTLEE 286
+ L R + +++ E +E + EN R + +EL ++ L+E
Sbjct: 1675 HENLEEMRSVTK--ERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKE 1732
Query: 287 MELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMA-----EAESQVSH 341
+ I+ + ++ + I + + L+ K+ + + R+A E + +
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792
Query: 342 LEVILDQKEKENIHLREELHR-RSQLQPEPAKTKA-------LQTVIEMKDTKIASLERN 393
L I+ +K + +++++L ++LQ + + KA L+ + K++ +E+
Sbjct: 1793 LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQL 1852
Query: 394 IRDLED--------EIQMLKANGVL--NTEDREEEIKQIEVYKSHSKFMKTKIDQLKQEL 443
+ ++D EI+ L L N E+ + +K+ + + + +K + DQLK+ L
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL 1912
Query: 444 SKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 503
+ ++ L +Q +L+T + + K+ ++ L+E ++ K + + +Q ++D + L++K
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI 1972
Query: 504 SFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQ-LRDKDKQL 562
L KK QL + E+ +I +M+ + + Q + +NL Q +R + QL
Sbjct: 1973 QELQKKELQLLRVKEDVNMSHKKINEMEQLKK---------QFEAQNLSMQSVRMDNFQL 2023
Query: 563 T-NLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKE 621
T L + ++ ++ + D E E+++ I L+E RD + + E
Sbjct: 2024 TKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD-----RQNHQVKPE 2078
Query: 622 NKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKL 681
+ L + L L EK S + +L + S + + LE IE +KE ++
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138
Query: 682 EAQLK----KAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVE 737
+A L + +IE N + + ++ K+ Y +L V
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKY-----------------VLSYVT 2181
Query: 738 NEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNS 797
K ++ + I + E + ++ Q + + ++H QQ + +L D + +
Sbjct: 2182 KIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSREL-------RDLKLNQN 2234
Query: 798 QHLQIEELMNALEKTR--------QELDATKARLASTQQSLAEKEAHLANLRIERRKQLE 849
L IEE++ ++ Q++ + + + + + L+ +K+ +
Sbjct: 2235 MDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEND 2294
Query: 850 EILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRL 897
I ++ I+ + + E SA+ K+ ++++ +LK + ++L
Sbjct: 2295 RICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL 2342
Score = 95.1 bits (235), Expect = 3e-19
Identities = 157/688 (22%), Positives = 278/688 (40%), Gaps = 119/688 (17%)
Query: 272 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRR 331
R KE+ L+K LEE+ L ET+ Q + +L ++L+ K L K + E R
Sbjct: 347 RYRKEIMDLKKQLEEVSL--ETRAQAMEK-----DQLAQLLEEKDLLQKVQNEKIENLTR 399
Query: 332 MAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLE 391
M S ++ L+ L K K + T L + +MK++ A
Sbjct: 400 MLVTSSSLT-LQQELKAKRKRRV------------------TWCLGKINKMKNSNYADQF 440
Query: 392 RNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELL 451
++ + L N + + E S S +D L + ++LL
Sbjct: 441 NIPTNITTKTHKLSINLLREID---------ESVCSESDVFSNTLDTLSEIEWNPATKLL 491
Query: 452 ALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTK 511
+ L++ +D + ++ T KE+ L+ + D L+E E+ L +KTK
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKND-----LDEFEA-LERKTK 545
Query: 512 QLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKS 571
+ Q++ L EI ++K++++ E L+ ++ + E LR+K+ Q+ L++ + S
Sbjct: 546 KDQEMQ-----LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
Query: 572 LQTDSSNTDTA--LATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKV 629
+ ++ D + L ++E+ K+ + + E + E R EN +LKEK+
Sbjct: 601 QKLENIKMDLSYSLESIEDPKQMKQTLFDA-----ETVALDAKRESAFLRSENLELKEKM 655
Query: 630 NALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAH 689
L + E+ D++ + S L + + K L+ A + + S ++ ++ K
Sbjct: 656 KELATTYKQMEN---DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPK-- 710
Query: 690 NIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILK---EVENEKNDKDKK 746
D N E +I L KE + +E + EV L E+ EVE + + K
Sbjct: 711 ----DLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 747 IAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQH------- 799
EL +T +++K + + H + + LLEE+ + +D +A +
Sbjct: 767 SEELHIIT----SEKDKLFSEVVHKES----RVQGLLEEIGKTKDDLATTQSNYKSTDQE 818
Query: 800 ------------------LQIEELMNA----LEKTRQELD----ATKARLASTQQSLAEK 833
L+ E MN L K Q+ D A K L+ Q L EK
Sbjct: 819 FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEK 878
Query: 834 EAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKRE 893
+ R+ +QL+E LE + L EK L K ++T EEV L +E
Sbjct: 879 TREVQE-RLNEMEQLKEQLENRDSTLQTVEREKT-------LITEKLQQTLEEVKTLTQE 930
Query: 894 KDRLVHQLKQQTQNRMKLMADNYDDDHH 921
KD L +Q Q +++ D D H
Sbjct: 931 KDDL-----KQLQESLQIERDQLKSDIH 953
Score = 56.6 bits (135), Expect = 1e-07
Identities = 107/511 (20%), Positives = 211/511 (41%), Gaps = 86/511 (16%)
Query: 471 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM 530
+ L+ + TAK + EV L+ + KQL++++ E A E +
Sbjct: 317 LTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQL 376
Query: 531 KDMLEVKERKINVLQKKIEN------------LQEQLRDKDKQ-----LTNLKDRVKSLQ 573
+LE K+ V +KIEN LQ++L+ K K+ L + S
Sbjct: 377 AQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNY 436
Query: 574 TDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQ 633
D N T + T LS + RE D ES E+ ++ L
Sbjct: 437 ADQFNIPTNITTKTHKLS--------INLLREID--------ESVCSESDVFSNTLDTLS 480
Query: 634 AELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIED 693
+ L++ + S L S D +L + EQ + E ++E +LK+ +++++
Sbjct: 481 EIEWNPATKLLNQENIESELNSLRADYD----NLVLDYEQLRTEKEEMELKLKEKNDLDE 536
Query: 694 DSRMNPEF-ADQIKQLDKEASYYRDECGKAQA---EVDRLLEILKEVENEKNDKDKKIAE 749
+ + DQ QL E S ++ A+ +++ L E+ EK D+ KK+ E
Sbjct: 537 FEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQE 596
Query: 750 -LESLTLRHMK-DQNKKVANLKHNQQLEKKK-NAQLLEEVRRREDSMADNSQHLQIEELM 806
++S L ++K D + + +++ +Q+++ +A+ + +RE + S++L+++E M
Sbjct: 597 YIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFL-RSENLELKEKM 655
Query: 807 NALEKT-----------RQELDATKARLASTQQSL------------------------- 830
L T + +L+A K ++ L
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCN 715
Query: 831 AEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMAL 890
E E + +L+ E K++EE +++E +L +SE + + +E + + EE+ +
Sbjct: 716 LELEGKITDLQKELNKEVEENEALREEVIL--LSELKSLPSEVERLRKEIQDKSEELHII 773
Query: 891 KREKDRLVHQL---KQQTQNRMKLMADNYDD 918
EKD+L ++ + + Q ++ + DD
Sbjct: 774 TSEKDKLFSEVVHKESRVQGLLEEIGKTKDD 804
Score = 53.1 bits (126), Expect = 1e-06
Identities = 136/648 (20%), Positives = 248/648 (38%), Gaps = 121/648 (18%)
Query: 144 DSTMLDLQAQLKELQR-ENDLLRKELDIKDS--KLGSSMNSIKTFWSPELKKERVLRK-- 198
D + +LQ +++ELQ+ E LLR + D+ S K+ K F + L + V
Sbjct: 1962 DKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNF 2021
Query: 199 EEAARMSVLKEQMRVSHEENQHLQLTIQALQDE----LRTQRDL------NHLLQQESG- 247
+ ++ E++R+ +E L+ ++L+ E + T R++ NH ++ E
Sbjct: 2022 QLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRL 2081
Query: 248 -NRGAEHFTIELTEENFR-----RLQAEHDRQAKELFLLRKTLE-------EMELRIETQ 294
+ G +H T L E+ R + +E D + L L LE E+ +R++
Sbjct: 2082 LSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKAN 2141
Query: 295 KQTLNARDESIKKLLEMLQSKGLP---------------SKSLEDDNERTRRMA-----E 334
+ + I+KL Q + +K E+ +E + E
Sbjct: 2142 LSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDE 2201
Query: 335 AESQ------VSHLEVILDQKEKE----------NIHLREELHRRSQLQPEPAKTKALQT 378
E Q + HL+ D +E ++H+ E L S+ + KT+ Q
Sbjct: 2202 VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQV 2261
Query: 379 VIEMKD-TKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKID 437
+ K+ T+ N R +I+ LK NG+ DR ++ + F +I
Sbjct: 2262 LSNRKEMTQFLEEWLNTRF---DIEKLK-NGIQKENDRICQV---------NNFFNNRII 2308
Query: 438 QLKQELSKKESELLALQTK----LETLSNQNSDCKQHIEVLKESLTAKEQ---------- 483
+ E ++ E + + L++L +N ++ + LK SL + Q
Sbjct: 2309 AIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKN 2368
Query: 484 -----RAAILQTE-VDALRLRLEE-------KESFLNKKTKQLQDLTEEKGTLAGEIRDM 530
RA L TE + L L E KES + K K+L+ + L ++ +
Sbjct: 2369 PHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHES 2428
Query: 531 KDMLEVKERKINVLQKKI----ENLQEQLRDKDKQLTNLK-DRVKSLQTDSSNTDTALAT 585
LE + I VLQ K+ + +E++ D +L + +++K+ + AT
Sbjct: 2429 NKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKAT 2488
Query: 586 LEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDL----------KEKVNALQAE 635
+E + E L+ ++ D + E + NK L K L++E
Sbjct: 2489 VEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSE 2548
Query: 636 LTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEA 683
E + LK+ L + S + L ++ KE K EA
Sbjct: 2549 HIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREA 2596
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 132 bits (331), Expect = 2e-30
Identities = 191/881 (21%), Positives = 392/881 (44%), Gaps = 127/881 (14%)
Query: 145 STMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIK--------TFWSPELKKERVL 196
+TM + ++KE +++ RKEL+ K L N ++ E + ++++
Sbjct: 852 ATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLI 911
Query: 197 RKEEAARMSVLKEQMRVSHEENQHLQLTI--QALQDEL-RTQRDLNH----LLQQESGNR 249
+ + V + R+ EE + +LT + L+DE ++D++ L + E
Sbjct: 912 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971
Query: 250 GAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM------ELRIETQK-QTLNARD 302
E+ LTEE A D +L +K L+E +L++E K +L+
Sbjct: 972 ATENKVKNLTEE-----MAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSK 1026
Query: 303 ESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHR 362
+++ ++ L+ K + D ER +R E + +++ E I+D E + + L E+L +
Sbjct: 1027 VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ-ESIMD-LENDKLQLEEKLKK 1084
Query: 363 R--------SQLQPEPAKTKALQTVIEMKDTKIASLERNI---RDLEDEIQMLKANGVLN 411
+ S+++ E LQ ++ +I LE + R +++ L+++
Sbjct: 1085 KEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE 1144
Query: 412 TEDREEEIK--------QIEVYKS-HSKFMKTKID----QLKQE-----LSKKESELLA- 452
E+ E ++ QIE+ K ++F K + D L+ E L KK ++ +A
Sbjct: 1145 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1204
Query: 453 -------LQTKLETLSNQNSDCKQHIE----VLKESLTAK---EQRAAILQTEVDALRLR 498
LQ + L + S+ K ++ +++ + AK E+ + L+ + + R++
Sbjct: 1205 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK 1264
Query: 499 LEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDK 558
LEE + LN T Q L E G LA ++ + + ++ R +++E+L+ QL ++
Sbjct: 1265 LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEE 1324
Query: 559 DKQLTNLKDRVKSLQTDS-------SNTDTALATLEEALSEKERIIERLKEQRERDDRER 611
K L ++S + D A A L+ LS+ + + + + E D +R
Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1384
Query: 612 LEEIESFRKE----NKDLKEKVNALQAELT-----------EKESSLIDLKEHASSLASA 656
EE+E +K+ +D +E V A+ A+ + E E ++D++ ++ A+
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAAL 1444
Query: 657 GLKR----------DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPE-FADQI 705
K+ K + + +E ++E L +L K N ++S + E F +
Sbjct: 1445 DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1504
Query: 706 KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKV 765
K L +E S ++ G+ V L ++ K++E EK + + E E+ +L H + + +
Sbjct: 1505 KNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEA-SLEHEEGKILR- 1562
Query: 766 ANLKHNQ---QLEKK--KNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATK 820
A L+ NQ ++E+K + + +E+ +R + D+ ++ ++A ++R E+ K
Sbjct: 1563 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS-----LQTSLDAETRSRNEVLRVK 1617
Query: 821 ARLASTQQSLAEKEAHLANLRIERRKQ---LEEILEMKQEALLAAISEKD---ANIALLE 874
++ + + +H + E +KQ L+ +L+ Q L A+ D NIA++E
Sbjct: 1618 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE 1677
Query: 875 LSASKKKKTQEEVMALKREKDR---LVHQLKQQTQNRMKLM 912
+ + EE+ A+ + +R L Q +T R++L+
Sbjct: 1678 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718
Score = 112 bits (280), Expect = 2e-24
Identities = 164/794 (20%), Positives = 327/794 (41%), Gaps = 81/794 (10%)
Query: 132 HHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELK 191
H + LR+ ++ +L Q+ LQR L KE +L ++++ +
Sbjct: 1187 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1246
Query: 192 KERVLR--KEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNR 249
E+V R +++A V E+ + S + + +Q EL Q + L + R
Sbjct: 1247 LEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQL-TR 1305
Query: 250 GAEHFTIELTEENFRRLQAEHDRQAKELF------------LLRKTL-EEMELRIETQKQ 296
G +T ++ E+ +R Q E + +AK LLR+ EE E + E Q+
Sbjct: 1306 GKLSYTQQM--EDLKR-QLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1362
Query: 297 TLNARDESIKKLLEMLQSKGLPSKSLEDDNER-TRRMAEAESQVSHLEVILDQKEKENIH 355
A E + + ++ LE+ ++ +R+ +AE V + EK
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 356 LREELHRRSQLQPEPAKTKALQTVIEMK----DTKIASLERNIRDLEDEIQ-MLKANGVL 410
L+ E+ L + ++ A ++ K D +A ++ + + E++ K L
Sbjct: 1423 LQNEI---EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1479
Query: 411 NTE------DREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQN 464
+TE EE ++ +E +K +K ++ +I L ++L + + L+ + L +
Sbjct: 1480 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEK 1539
Query: 465 SDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE----EKESFLNKKTKQLQDLTEEK 520
+ + +E + SL +E + Q E + ++ +E EK+ + + + Q + +
Sbjct: 1540 LELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSL 1599
Query: 521 GT-LAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNT 579
T L E R ++L VK++ ++ + ++ QL ++ + +VKSLQ+ +T
Sbjct: 1600 QTSLDAETRSRNEVLRVKKK----MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1655
Query: 580 DTAL---ATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAEL 636
L + L E I+ER + E+E R + + + EL
Sbjct: 1656 QIQLDDAVRANDDLKENIAIVERRNNLLQ-------AELEELRAVVEQTERSRKLAEQEL 1708
Query: 637 TEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSR 696
E + L +SL + K +S L L+ +E+ +EC E + KKA
Sbjct: 1709 IETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAIT------ 1762
Query: 697 MNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLR 756
+A+ +E K Q L + K +E D ++ E E + L+
Sbjct: 1763 --------------DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALK 1808
Query: 757 HMKDQNKK----VANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKT 812
K Q +K V L+ + E+K+NA+ ++ +R+ E + + + Q EE L +
Sbjct: 1809 GGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELT--YQTEEDKKNLLRL 1866
Query: 813 RQELDATKARLASTQQSLAEKEAHLANLRIER-RKQLEEILEMKQEALLAAISEKDANIA 871
+ +D + ++ + ++ AE+ AN + + RK E+ E ++ A +A
Sbjct: 1867 QDLVDKLQLKVKAYKRQ-AEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1925
Query: 872 LLELSASKKKKTQE 885
++ A +K +E
Sbjct: 1926 SRDIGAKQKMHDEE 1939
Score = 110 bits (274), Expect = 8e-24
Identities = 133/663 (20%), Positives = 288/663 (43%), Gaps = 72/663 (10%)
Query: 124 LTGSSHHHHHQVPSMLRQVRDSTMLD--LQAQLKELQRENDLLRKELDIKDS------KL 175
LT + Q+ + RQ+ + L L+ + + DLLR++ + + ++
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1362
Query: 176 GSSMNSIKTFWSPELKKERVLRKEE--------AARMSVLKEQMRVSHEENQHLQLTIQA 227
S NS W + + + + R EE A R+ +E + + + L+ T
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 228 LQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM 287
LQ+E+ DL ++ E N A ++ + NF ++ AE ++ +E + LE
Sbjct: 1423 LQNEIE---DL--MVDVERSNAAAA--ALDKKQRNFDKILAEWKQKYEES---QSELESS 1472
Query: 288 ELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD-NERTRRMAEAESQVSHLEVIL 346
+ + L + ++ LE L++ +K+L+++ ++ T ++ E V LE +
Sbjct: 1473 QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532
Query: 347 DQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKA 406
Q E E + L+ L ++ E + K L+ +E K A +ER + + ++E++ K
Sbjct: 1533 KQLEVEKLELQSALEE-AEASLEHEEGKILRAQLEFNQIK-AEIERKLAEKDEEMEQAKR 1590
Query: 407 NGV-----------LNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQT 455
N T R E ++ + + M+ ++ + ++ + ++ +LQ+
Sbjct: 1591 NHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQS 1650
Query: 456 KLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQD 515
L+ Q D + + LKE++ E+R +LQ E++ LR +E+ E ++L +
Sbjct: 1651 LLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1710
Query: 516 LTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTD 575
+E L + + + + E + LQ ++E ++ R N +++ K TD
Sbjct: 1711 TSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECR-------NAEEKAKKAITD 1763
Query: 576 SSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAE 635
++ L ++ + ER+ + + EQ +D + RL+E E K K+++ L+A
Sbjct: 1764 AAMMAEELKKEQDTSAHLERMKKNM-EQTIKDLQHRLDEAEQIAL--KGGKKQLQKLEAR 1820
Query: 636 LTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDS 695
+ E E L ++ + K + ++K L E+ K+ +L+
Sbjct: 1821 VRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQ------------- 1867
Query: 696 RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKK--IAELESL 753
D + +L + Y+ + +A+ + + L ++V++E ++ +++ IAE +
Sbjct: 1868 -------DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1920
Query: 754 TLR 756
LR
Sbjct: 1921 KLR 1923
Score = 104 bits (259), Expect = 4e-22
Identities = 176/808 (21%), Positives = 342/808 (42%), Gaps = 137/808 (16%)
Query: 187 SPELKKERVLRKEE-----------AARMSVLKEQMRVSHEENQHLQLTIQALQDEL--- 232
S E +KE KEE AR L+E+M +E LQL +QA QD L
Sbjct: 844 SAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDA 903
Query: 233 --RTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELR 290
R + + + +Q E+ + +E EE L A+ + E L+K ++++EL
Sbjct: 904 EERCDQLIKNKIQLEAKVKEMNE-RLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 291 IETQKQTLNARDESIKKLLEML--------------------QSKGLPSKSLEDD--NER 328
+ ++ +A + +K L E + + L +E+D N
Sbjct: 963 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSL 1022
Query: 329 TRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIA 388
++ + E QV LE L+Q++K + L E AK K L+ +++ I
Sbjct: 1023 SKSKVKLEQQVDDLEGSLEQEKKVRMDL------------ERAKRK-LEGDLKLTQESIM 1069
Query: 389 SLERNIRDLEDEIQMLKAN-GVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKE 447
LE + LE++++ + + N++ +E++ +++ K K + +I++L++EL E
Sbjct: 1070 DLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKK-LKENQARIEELEEEL---E 1125
Query: 448 SELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLN 507
+E A + K+E L SD + +E + E L + A +Q E++ +++E+
Sbjct: 1126 AERTA-RAKVEKL---RSDLSRELEEISERLE-EAGGATSVQIEMN------KKREAEFQ 1174
Query: 508 KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKD 567
K + L++ T + A +R K V E L ++I+NLQ + +K+ + K
Sbjct: 1175 KMRRDLEEATLQHEATAAALRK-KHADSVAE-----LGEQIDNLQRVKQKLEKEKSEFKL 1228
Query: 568 RVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEE----IESFRKENK 623
+ + ++ A A LE+ + R E + + R +LEE + F +
Sbjct: 1229 ELDDVTSNMEQIIKAKANLEK--------VSRTLEDQANEYRVKLEEAQRSLNDFTTQRA 1280
Query: 624 DLKEKVNALQAELTEKESSLIDLKEHASSLASA------GLKRDSKLKS-LEIAIEQKKE 676
L+ + L +L EKE+ + L S L+ + K K+ L A++ +
Sbjct: 1281 KLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARH 1340
Query: 677 ECSKLEAQLKKAHNIEDD-----SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
+C L Q ++ + + S+ N E A + + +A +E +A+ ++ + L+
Sbjct: 1341 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1400
Query: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
+E N A+ SL + QN+ + +L + + A L ++ R +
Sbjct: 1401 DAEEAVEAVN------AKCSSLEKTKHRLQNE-IEDLMVDVERSNAAAAALDKKQRNFDK 1453
Query: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEI 851
+A+ Q + EE + LE +++E + L + + E HL + E + EEI
Sbjct: 1454 ILAEWKQ--KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1511
Query: 852 -----------------------LEMKQEALLAAISEKDANIALLELSASKKKKTQEEVM 888
LE+++ L +A+ E +A+ LE K + Q E
Sbjct: 1512 SDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEAS---LEHEEGKILRAQLEFN 1568
Query: 889 ALKREKDRLV----HQLKQQTQNRMKLM 912
+K E +R + +++Q +N +++
Sbjct: 1569 QIKAEIERKLAEKDEEMEQAKRNHQRVV 1596
Score = 103 bits (258), Expect = 6e-22
Identities = 111/528 (21%), Positives = 234/528 (44%), Gaps = 69/528 (13%)
Query: 432 MKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRA------ 485
MK + ++K+ L K E+ L+ K+ +L + +D + ++ +++L E+R
Sbjct: 854 MKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKN 913
Query: 486 -AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVL 544
L+ +V + RLE++E + T + + L +E L +I D++ L E++ +
Sbjct: 914 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Query: 545 QKKIENLQEQLRDKDKQLTNL---------------------KDRVKSLQTDSSNTDTAL 583
+ K++NL E++ D+ + L +D+V SL + +
Sbjct: 974 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQV 1033
Query: 584 ATLEEALSEKERI---IERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKE 640
LE +L +++++ +ER K + E D + E I + L+EK+ + ++ ++
Sbjct: 1034 DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQN 1093
Query: 641 SSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDD-SRMNP 699
S + D + A L+ KLK + IE+ +EE K + D SR
Sbjct: 1094 SKIEDEQVLA-------LQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELE 1146
Query: 700 EFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMK 759
E ++++++ S + K +AE ++ L+E + + + + ++ +
Sbjct: 1147 EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG 1206
Query: 760 DQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHL-----QIEELMNALEKTRQ 814
+Q + +K Q+LEK+K+ E + D + N + + +E++ LE
Sbjct: 1207 EQIDNLQRVK--QKLEKEKS-----EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQAN 1259
Query: 815 ELDATKARLASTQQSLAEKEAHLANLRIER---RKQLEEILEMKQEALLAAISEKDANIA 871
E + +L Q+SL + A L+ E +QLEE +EAL++ ++ ++
Sbjct: 1260 EY---RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE-----KEALISQLTR--GKLS 1309
Query: 872 LLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDD 919
+ K++ +EE A K+ L H L Q ++ L+ + Y+++
Sbjct: 1310 YTQQMEDLKRQLEEEGKA----KNALAHAL-QSARHDCDLLREQYEEE 1352
Score = 98.2 bits (243), Expect = 3e-20
Identities = 124/630 (19%), Positives = 282/630 (44%), Gaps = 81/630 (12%)
Query: 348 QKEKENIHLREELHR-RSQLQPEPAKTKALQ----TVIEMKDT---KIASLERNIRDLED 399
+ EKE ++EE R + L+ A+ K L+ ++++ K+ ++ + + N+ D E+
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 400 EIQMLKANGV--------LNTEDREEEIKQIEVYKSHSKF------MKTKIDQLKQELSK 445
L N + +N +EE E+ K +K ID L+ L+K
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965
Query: 446 KESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESF 505
E E A + K++ L+ + + + I L + A ++ Q +D L++ ++ S
Sbjct: 966 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH---QQALDDLQVEEDKVNSL 1022
Query: 506 LNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNL 565
K K Q + + +G+L E + D+ K + L+ ++ QE + D + L
Sbjct: 1023 SKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRK----LEGDLKLTQESIMDLENDKLQL 1078
Query: 566 KDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDL 625
++++K + D + ++ + E E+++ +++ ++++ R+EE+E + +
Sbjct: 1079 EEKLKKKEFDINQQNSKI--------EDEQVLALQLQKKLKENQARIEELEEELEAERTA 1130
Query: 626 KEKVNALQAELTEKESSLIDLKEHASSLASAGL----KRDSKLKSLEIAIEQKKEECSKL 681
+ KV L+++L+ + + + E A S + KR+++ + + +E+ +
Sbjct: 1131 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1190
Query: 682 EAQLKKAH--NIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLL-------EI 732
A L+K H ++ + ++L+KE S ++ E + +++++ ++
Sbjct: 1191 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKV 1250
Query: 733 LKEVENEKNDKDKKIAELESLTLRHMKDQNKKV--ANLKHNQQLEKKKNAQLLEEVRRRE 790
+ +E++ N+ K+ E + +L Q K+ N + +QLE+K+ L+ ++ R +
Sbjct: 1251 SRTLEDQANEYRVKLEEAQR-SLNDFTTQRAKLQTENGELARQLEEKE--ALISQLTRGK 1307
Query: 791 DSMADNSQHL--QIEE-------LMNALEKTRQELDATKARL-------ASTQQSLAEKE 834
S + L Q+EE L +AL+ R + D + + A Q+ L++
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367
Query: 835 AHLANLR-------IERRKQLEEI---LEMKQEALLAAISEKDANIALLELSASKKKKTQ 884
+ +A R I+R ++LEE L + + A+ +A + LE + + +
Sbjct: 1368 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI 1427
Query: 885 EEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
E++M + L ++ +N K++A+
Sbjct: 1428 EDLMVDVERSNAAAAALDKKQRNFDKILAE 1457
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 131 bits (330), Expect = 3e-30
Identities = 185/850 (21%), Positives = 363/850 (42%), Gaps = 103/850 (12%)
Query: 150 LQAQLKELQR---ENDLLRKELDIKDSKLGSSMNSIKTFWSP-ELKKERVLRKEEAAR-- 203
L+A++KE+ + + + EL K KL + +K EL +V +++ A
Sbjct: 916 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 975
Query: 204 -------MSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI 256
+S L E + E + LQ Q D+L+ + D + L + + +
Sbjct: 976 VKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDL 1035
Query: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 316
E + E ++L+ + +R ++L K +E L +E KQ L+ R + LQSK
Sbjct: 1036 ESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 1095
Query: 317 LPSKSL-----EDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPA 371
++L + E R+ E E ++ + EK+ EL S+ E
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 1155
Query: 372 KTKALQTVIEMKDTKIASLERNIRDLEDE----------IQMLKANGVLNTEDREEEIKQ 421
+ Q IE+ + A + RDLE+ ++ A+ V ++ + +++
Sbjct: 1156 GVTSTQ--IELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQR 1213
Query: 422 IE--VYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLT 479
++ + K S+F K +ID L + L+ TL +Q S+ + E ++ SL+
Sbjct: 1214 VKQKLEKEKSEF-KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS 1272
Query: 480 AKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRD-------MKD 532
+ + LQTE L +LEEKES +++ ++ Q T++ L ++ + +
Sbjct: 1273 ELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAH 1332
Query: 533 MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSE 592
L+ ++L+++ E QE + + L+ V +T TD A+ EE
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT-KYETD-AIQRTEELEEA 1390
Query: 593 KERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASS 652
K+++ +RL++ E++E+ + L++ LQ E+ E ++D+ E A+S
Sbjct: 1391 KKKLAQRLQDSE--------EQVEAVNAKCASLEKTKQRLQGEV---EDLMVDV-ERANS 1438
Query: 653 LASAGLKRDSKLKSLEIAIEQKKEEC----SKLEAQLKKAHNIEDD----SRMNPEFADQ 704
LA+A D K ++ + + + K +C ++LEA LK++ ++ + E DQ
Sbjct: 1439 LAAA---LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ 1495
Query: 705 I-------KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELES----- 752
+ K L++E + ++ + + L + K++E EK D + E E+
Sbjct: 1496 LETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHE 1555
Query: 753 --------LTLRHMK--------DQNKKVANLKHN-QQLEKKKNAQLLEEVRRREDSM-A 794
L L +K ++++++ LK N Q+ + + L EVR R +++
Sbjct: 1556 EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL 1615
Query: 795 DNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEE---I 851
+ E+ L ++ T L S Q L + + HL + + ++ L+E I
Sbjct: 1616 KKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDD-ALRGQEDLKEQLAI 1674
Query: 852 LEMKQEALLAAISEKDANIALLE----LSASKKKKTQEEVMALKREKDRLVHQLKQQTQN 907
+E + L A + E A + E L+ + + E V L + L+H K+ +
Sbjct: 1675 VERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETD 1734
Query: 908 RMKLMADNYD 917
M+L ++ D
Sbjct: 1735 LMQLQSEVED 1744
Score = 130 bits (327), Expect = 6e-30
Identities = 173/850 (20%), Positives = 379/850 (44%), Gaps = 111/850 (13%)
Query: 144 DSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKK-ERVLRKEEAA 202
D T+ L + K LQ + +L ++ K+ +S+N K+ +++ E L +E+
Sbjct: 987 DETIAKLTREKKALQEAHQQALDDLQAEEDKV-NSLNKTKSKLEQQVEDLESSLEQEKKL 1045
Query: 203 RMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEEN 262
R+ + + + ++ + L+L +++ D ++ L+ L+++ E+ ++ E+
Sbjct: 1046 RVDLERNKRKLEGD----LKLAQESILDLENDKQQLDERLKKKD----FEYCQLQSKVED 1097
Query: 263 FRRLQAEHDRQAKELFLLRKTLEEMELRIE----TQKQTLNARDESIKKLLEMLQ----S 314
+ L + ++ KEL + +EE+E IE T+ +T R + ++L E+ + +
Sbjct: 1098 EQTLGLQFQKKIKEL---QARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA 1154
Query: 315 KGLPSKSLEDDNERT-------RRMAEAESQVSHLEVILDQKEKENI-HLREELHRRSQL 366
G+ S +E + +R R + EA Q + L +K +++ L E++ ++
Sbjct: 1155 GGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRV 1214
Query: 367 QPEPAKTKA--------LQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEE 418
+ + K K+ L + +E A+LE+ R LED Q+ +A G E+ +
Sbjct: 1215 KQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED--QLSEARG--KNEEIQRS 1270
Query: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESL 478
+ ++ KS ++T+ +L ++L +KES + L + + Q + K+ +E E
Sbjct: 1271 LSELTTQKSR---LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE---EEN 1324
Query: 479 TAKEQRAAILQT---EVDALRLRLEEKES-------FLNKKTKQL--------------- 513
AK A LQ+ + D LR + EE++ L+K ++
Sbjct: 1325 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1384
Query: 514 QDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQ 573
++L E K LA ++D ++ +E K L+K + LQ ++ D + +L
Sbjct: 1385 EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 1444
Query: 574 TDSSNTDTALATLEEALSEKERIIER-LKEQRERDDR---------ERLEEIESFRKENK 623
N D LA + E + +E LKE R E L+++E+ ++ENK
Sbjct: 1445 KKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 1504
Query: 624 DLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEA 683
+L++++ L ++ E ++ +L++ + L+ E A+E ++ + +++
Sbjct: 1505 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL 1564
Query: 684 QLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDK 743
+L + S ++ + A++ +++++ Y+ Q+ +D + E K
Sbjct: 1565 ELTQVK-----SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKM 1619
Query: 744 DKKIAELESLTLRHMKDQNKKVANLKHNQQLEKK-KNAQL-LEEVRRREDSMAD------ 795
+ + E+E + L H Q + LKH + ++ + K+ QL L++ R ++ + +
Sbjct: 1620 EGDLNEIE-IQLSHANRQAAET--LKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676
Query: 796 ---NSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEIL 852
N ++EEL LE+T + + L + + + +L ++K +++
Sbjct: 1677 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLM 1736
Query: 853 EMKQEALLAAISEKDANIALLELSASKKKKTQEEVMA--LKREKDRLVH--QLKQQTQNR 908
+++ E A+ ++A +KK T +MA LK+E+D H ++K+ +
Sbjct: 1737 QLQSEVEDASRDARNAE------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1790
Query: 909 MKLMADNYDD 918
+K + D+
Sbjct: 1791 VKDLQHRLDE 1800
Score = 110 bits (276), Expect = 5e-24
Identities = 114/517 (22%), Positives = 233/517 (45%), Gaps = 47/517 (9%)
Query: 432 MKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRA------ 485
MK + + K EL+K E++ L+ KL TL + +D + ++ E+L E+R
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA 912
Query: 486 -AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVL 544
L+ ++ + R E++E + T + + L +E L +I D++ L E++ +
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 545 QKKIENLQEQLRDKDKQLTNLKDRVKSLQ-------TDSSNTDTALATLEEALSEKERII 597
+ K++NL E+L D+ + L K+LQ D + + +L + S+ E+ +
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV 1032
Query: 598 ERLKEQRERDDRERLEEIESFRKENKDLK----------EKVNALQAELTEKESSLIDLK 647
E L+ E++ + R++ + RK DLK L L +K+ L+
Sbjct: 1033 EDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQ 1092
Query: 648 EHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDD-SRMNPEFADQIK 706
+ GL+ K+K L+ IE+ +EE A K D +R E +++++
Sbjct: 1093 SKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLE 1152
Query: 707 QLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA 766
+ S + K +AE L++ +++E + +A L + + +++
Sbjct: 1153 EAGGVTSTQIELNKKREAE---FLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQID 1209
Query: 767 NLKH-NQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLAS 825
NL+ Q+LEK+K+ LE + + +E++ LE +L + +
Sbjct: 1210 NLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE---DQLSEARGKNEE 1266
Query: 826 TQQSLAEKEAHLANLRIER---RKQLEEILEMKQEALLAAISEKDANIALLELSASKKKK 882
Q+SL+E + L+ E +QLEE +E++++ +S + A + + K++
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEE-----KESIVSQLSR--SKQAFTQQTEELKRQ 1319
Query: 883 TQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDD 919
+EE + K+ L H L Q +++ L+ + Y+++
Sbjct: 1320 LEEE----NKAKNALAHAL-QSSRHDCDLLREQYEEE 1351
Score = 108 bits (270), Expect = 2e-23
Identities = 146/658 (22%), Positives = 284/658 (43%), Gaps = 58/658 (8%)
Query: 124 LTGSSHHHHHQVPSMLRQVRDSTMLD--LQAQLKELQRENDLLRKELDIKDS------KL 175
L+ S Q + RQ+ + L L+ + + DLLR++ + + +
Sbjct: 1302 LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 1361
Query: 176 GSSMNSIKTFWSPELKKERVLRKEE--------AARMSVLKEQMRVSHEENQHLQLTIQA 227
S NS W + + + + R EE A R+ +EQ+ + + L+ T Q
Sbjct: 1362 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQR 1421
Query: 228 LQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFL-LRKTLEE 286
LQ E+ DL ++ E N A ++ + NF ++ AE + +E L +L+E
Sbjct: 1422 LQGEVE---DL--MVDVERANSLAA--ALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474
Query: 287 MELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD-NERTRRMAEAESQVSHLEVI 345
+ NA +E+ L+ L++ +K+LE + + T ++AE + LE
Sbjct: 1475 SRSLSTELFKLKNAYEEA----LDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKS 1530
Query: 346 LDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLK 405
Q E E ++ L ++ E + K L+ +E+ K + ++R I + ++EI+ LK
Sbjct: 1531 RKQIELEKADIQLALEE-AEAALEHEEAKILRIQLELTQVK-SEIDRKIAEKDEEIEQLK 1588
Query: 406 ANGVLNTEDREE----EIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLS 461
N E + E++ K M+ +++++ +LS + L ++
Sbjct: 1589 RNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQ 1648
Query: 462 NQNSDCKQHI-------EVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQ 514
Q D + H+ E LKE L E+RA +LQ EV+ LR LE+ E ++L
Sbjct: 1649 GQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELL 1708
Query: 515 DLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQT 574
D E L + ++ K++ L+ + LQ ++ D + N +++ K T
Sbjct: 1709 DSNERVQLLHTQ---NTSLIHTKKK----LETDLMQLQSEVEDASRDARNAEEKAKKAIT 1761
Query: 575 DSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQA 634
D++ L ++ + ER+ + L EQ +D + RL+E E K K+++ L+
Sbjct: 1762 DAAMMAEELKKEQDTSAHLERMKKNL-EQTVKDLQHRLDEAEQLAL--KGGKKQIQKLET 1818
Query: 635 ELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDD 694
+ E E L ++ + K + ++K L E+ ++ +L+ + K ++
Sbjct: 1819 RIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKL-QVKVK 1877
Query: 695 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELES 752
S + Q ++ D++A+ + + KAQ E++ E E++ N K + S
Sbjct: 1878 S-----YKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTS 1930
Score = 104 bits (260), Expect = 3e-22
Identities = 153/680 (22%), Positives = 287/680 (42%), Gaps = 125/680 (18%)
Query: 348 QKEKENIHLREELHR-RSQLQPEPAKTKALQ----TVIEMKDT---KIASLERNIRDLED 399
+ EKE ++EE + + +L AK K L+ T+++ K+ ++ + N+ D E+
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 400 EI-QMLKANGVLN------TEDREEEIKQIEVYKSHSKFMKTKIDQLKQE-------LSK 445
Q++KA L TE E+E + + + ++ + +LK++ L+K
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 446 KESELLALQTKLETLSNQNSDCKQHIEVLK--------------ESLTAKEQRAAILQTE 491
E E A + K++ L+ + S + I L + L A+E + L
Sbjct: 965 VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024
Query: 492 VDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENL 551
L ++E+ ES L ++ K DL K L G+ L++ + I L+ + L
Sbjct: 1025 KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGD-------LKLAQESILDLENDKQQL 1077
Query: 552 QEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIE-----RLKEQRER 606
E+L+ KD + L+ +V+ QT + L+ + E E IE R K +++R
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQR 1137
Query: 607 DD--------RERLEE--------IESFRKENKDLKEKVNALQAELTEKESSLIDL-KEH 649
D ERLEE IE +K + + L+ + E+ + L K+H
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKH 1197
Query: 650 ASSLASAGLKRDSKLKSLEIAIEQKKEE--------CSKLEAQLKKAHNIEDDSR----- 696
A S+A G + D+ L+ ++ +E++K E S +E+ K N+E R
Sbjct: 1198 ADSVAELGEQIDN-LQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQ 1256
Query: 697 ------MNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAEL 750
N E + +L + S + E G+ +++ I+ ++ K ++ EL
Sbjct: 1257 LSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEEL 1316
Query: 751 ESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMAD--------NSQHLQ- 801
+ R ++++NK L H Q + L E+ ++ A+ NS+ Q
Sbjct: 1317 K----RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Query: 802 -----------IEELMNA-------LEKTRQELDATKARLASTQQSLAEKEAHLANLR-- 841
EEL A L+ + ++++A A+ AS +++ + + +L
Sbjct: 1373 RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVD 1432
Query: 842 IERRKQLEEILEMKQ---EALLAAISEK-DANIALLELSASKKKKTQEEVMALKREKDRL 897
+ER L L+ KQ + +LA K + + A LE S + + E+ LK +
Sbjct: 1433 VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA 1492
Query: 898 VHQL---KQQTQNRMKLMAD 914
+ QL K++ +N + +AD
Sbjct: 1493 LDQLETVKRENKNLEQEIAD 1512
Score = 52.4 bits (124), Expect = 2e-06
Identities = 99/447 (22%), Positives = 178/447 (39%), Gaps = 88/447 (19%)
Query: 153 QLKELQRENDLLRKELDIKDSKLGSSMNSI----KTFWSPELKK----------ERVLRK 198
QL+ ++REN L +E+ ++ + +I K+ EL+K E L
Sbjct: 1495 QLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH 1554
Query: 199 EEAARMSVLKEQMRVSHEENQHL--------------QLTIQALQDEL------------ 232
EEA + + E +V E ++ + Q T++ +Q L
Sbjct: 1555 EEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR 1614
Query: 233 ---RTQRDLNHL-LQQESGNRGAEHFTIELTEENFRRLQAE-HDRQAKELFLLR--KTLE 285
+ + DLN + +Q NR A T ++ R +Q + D Q LR + L+
Sbjct: 1615 LKKKMEGDLNEIEIQLSHANRQAAE-----TLKHLRSVQGQLKDTQLHLDDALRGQEDLK 1669
Query: 286 EMELRIETQKQTLNARDESIKKLLEMLQ-SKGLPSKSLEDDNERTRRMAEAESQVSHLEV 344
E +E + L A E ++ LE + ++ L + L D NER + + + + H +
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Query: 345 ILDQKEKENIHLREELH------RRSQLQPEPAKTKALQTVIEMKDTKIAS--------- 389
L E + + L+ E+ R ++ + + A T A E+K + S
Sbjct: 1730 KL---ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1786
Query: 390 LERNIRDLE---DEIQMLKANG------VLNTEDRE-------EEIKQIEVYKSHSKFMK 433
LE+ ++DL+ DE + L G L T RE E+ K E K K+ +
Sbjct: 1787 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYER 1846
Query: 434 TKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVD 493
++ +L + + +L LQ ++ L + K+ E E A + Q E++
Sbjct: 1847 -RVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELE 1905
Query: 494 ALRLRLEEKESFLNKKTKQLQDLTEEK 520
R + ES +NK + +D T +
Sbjct: 1906 EAEERADIAESQVNKLRAKTRDFTSSR 1932
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 131 bits (329), Expect = 3e-30
Identities = 179/849 (21%), Positives = 385/849 (45%), Gaps = 101/849 (11%)
Query: 142 VRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEA 201
++ T+ +L+AQL++L E + L +L N IK S + E ++ ++EA
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK---SMKADIESLVTEKEA 1322
Query: 202 ARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI--ELT 259
+ +Q S +E+ I L+ EL + L+++E + E ++ +LT
Sbjct: 1323 LQKEGGNQQQAASEKES-----CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 260 EENFRRLQAEHDRQAKELFL--LRKTLEEMELRIETQKQTLNARDESI--KKLLEMLQSK 315
+ N + LQ KE + LRK +E + + Q Q L+ + +++ +K+ + Q
Sbjct: 1378 DLNVQ-LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVD 1436
Query: 316 GLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIH-------LREELHRRSQL-- 366
+K E + R + ++ V L++ L+ K KE L+EEL ++++
Sbjct: 1437 DWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD 1496
Query: 367 ----QPEPAKTKA------LQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDRE 416
+ E K+K L+T ++ + +I LE +I EI+ L N VL +++
Sbjct: 1497 CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESL--NEVLKNYNQQ 1554
Query: 417 EEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE 476
++I+ E+ + F + ++ + + E ++L L+ ++ ++ + K+ +E +
Sbjct: 1555 KDIEHKELVQKLQHFQELG-EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
Query: 477 SLTAKEQRAAILQTEVDA--------LRLRLEEKESFLNKKTKQLQDLTEE---KGTLAG 525
S+ +KE+ L+ +++ L+ + E+K + + K+ + EE KGT
Sbjct: 1614 SVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT-ES 1672
Query: 526 EIRDMKDMLEVKERKINVLQKK---IENLQEQLRDKDKQLTNLKDRVKSLQTDSSNT--- 579
+ ++ L+ +ER++++L++K +E+ Q + + N+ + + DS
Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK 1732
Query: 580 --DTALATLEEALSEKERIIERLKEQRER----------DDRERLEEIESFRKENKDLKE 627
+ ++ L+ L+EKE++++R+ +++E +ERL ++E + + +
Sbjct: 1733 TYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQS 1792
Query: 628 KVNALQAELTEKES--SLIDL----KEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKL 681
+ LQ EL EK SLI KE + A ++ ++ +++K+ C L
Sbjct: 1793 MIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852
Query: 682 EAQLKK----------AHNIE-DDSRMNPEFADQIKQLD---KEASYYRDECGKAQAEVD 727
E ++K+ H +E ++ E ++Q+D K + +
Sbjct: 1853 EQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHL 1912
Query: 728 RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVR 787
++L +E + ND + K+A E R + K++ L+ + ++ +K++ Q LE ++
Sbjct: 1913 VQPKLLSNMEAQHNDLEFKLAGAE----REKQKLGKEIVRLQKDLRMLRKEHQQELEILK 1968
Query: 788 RREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLA-NLRIERRK 846
+ D + + E+L T ++L R +TQ + E+E + I + +
Sbjct: 1969 KEYDQEREEKIKQEQEDLELKHNSTLKQL----MREFNTQLAQKEQELEMTIKETINKAQ 2024
Query: 847 QLE-EILEMKQEA---LLAAISEKDANIALLELSASKKKKTQEEVMALK-REKDRLVHQL 901
++E E+LE QE LL I+EKD ++ + +EE M K R+ + +L
Sbjct: 2025 EVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEEL 2084
Query: 902 KQQTQNRMK 910
+++ Q +++
Sbjct: 2085 QKKYQQKLE 2093
Score = 127 bits (319), Expect = 5e-29
Identities = 170/804 (21%), Positives = 327/804 (40%), Gaps = 108/804 (13%)
Query: 149 DLQAQLKELQRENDL-------LRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEA 201
+++AQ K++ E D L ++L+ ++S++ + S+ + +L+ +E+
Sbjct: 844 EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK-EQEQT 902
Query: 202 ARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEE 261
++ V KE M + E Q ++ I L +L + D H+L +E
Sbjct: 903 KQILVEKENMILQMREGQKKEIEI--LTQKLSAKEDSIHILNEE---------------- 944
Query: 262 NFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKS 321
+ + Q K++ +++ +EM+ ET K+ L ++ +KK LE + S+
Sbjct: 945 ----YETKFKNQEKKMEKVKQKAKEMQ---ETLKKKLLDQEAKLKKELENTALE--LSQK 995
Query: 322 LEDDNERTRRMAEAESQ-VSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKAL-QTV 379
+ N + MA+A S +S L+ +KE I E+HRR K L Q
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 380 IEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQL 439
E+++ E +++ E E+ LK +L ++EE K+I K T +++L
Sbjct: 1056 EELQEIH----EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111
Query: 440 KQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 499
+++L +K + + +L+ + K H+E L+ L + LQ ++ L++
Sbjct: 1112 QEQLKQKSAHV-------NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 500 EEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKI--------ENL 551
EE + +++ T +L+ EE +L LE K + L +++ +
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 552 QEQLRDKDKQLTNLKD--------RVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQ 603
+ L K +L N+ R+ Q ++ AL +SE E + +L E+
Sbjct: 1225 EALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284
Query: 604 -----------------RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDL 646
+E + +IES E + L+++ Q +EKES + L
Sbjct: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344
Query: 647 KEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIK 706
K+ S +A +LK ++ I ++ + L QL+ + ++ S + K
Sbjct: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL---SEKEAAISSLRK 1401
Query: 707 QLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA 766
Q D+E D+ +VD L + + +D K +E KK A
Sbjct: 1402 QYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW------------KKKA 1449
Query: 767 NLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLAST 826
+ Q K Q+ E++ +E D QI L L++ + D K +
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDE----QINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 827 QQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEE 886
+ + +KE +NL E + Q I+E++ I + N L + K + +E
Sbjct: 1506 KSKMEKKE---SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL 1562
Query: 887 VMALKREKDRLVHQLKQQTQNRMK 910
V L+ +L ++ NR+K
Sbjct: 1563 VQKLQH-----FQELGEEKDNRVK 1581
Score = 126 bits (317), Expect = 8e-29
Identities = 190/935 (20%), Positives = 399/935 (42%), Gaps = 185/935 (19%)
Query: 132 HHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELK 191
H + ++L +++ L +L+EL++ DL E ++L + N I+ +L+
Sbjct: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIE-----QLE 359
Query: 192 KERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQ---DELRTQRDLNHLLQQESGN 248
+++ + E R + E + + EE L+ I+ + +ELR Q++ + E
Sbjct: 360 QDKGMVIAETKRQ--MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417
Query: 249 RGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQ----KQTL-----N 299
+ T + TEE R+L+AE D Q K + KT EE + ++ + KQ +
Sbjct: 418 KALS--TAQKTEEARRKLKAEMDEQIKTI---EKTSEEERISLQQELSRVKQEVVDVMKK 472
Query: 300 ARDESIKKLLEMLQSKGLPSK---------SLEDDNERTRRMAEAESQVSHLEVILDQKE 350
+ +E I KL + L K L K + E + + ++A +SQ +L++ ++++
Sbjct: 473 SSEEQIAKL-QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ 531
Query: 351 KENIHLRE-ELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIR-------------- 395
+E++ L E EL +++ L K + LQ E T+I LE ++
Sbjct: 532 QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591
Query: 396 -----------------------DLE-----------DEIQMLKANGVLNTEDREEEIKQ 421
+LE +++Q+LK E E+ +Q
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Query: 422 IE---------VYKSHSKFM-----------KTKIDQLKQELSKKESELLALQTKLETLS 461
+ ++++H + M +T+++ L ELS+ L+ +L L
Sbjct: 652 EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLK 711
Query: 462 NQNSDCKQHIE----------------VLKESLTAKEQRAAILQTEVDALRLRLEEKESF 505
+Q KQ +E ++KE + ++ L+ +++ L L L+E++
Sbjct: 712 DQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKH 771
Query: 506 LNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNL 565
L + +++ L +I+ + L+ K++V Q EQ + ++QL L
Sbjct: 772 LKEHQAHVEN-------LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 566 KDRVKSLQTDSSNTDTALATLE-------EALSEKERIIERLKEQRERDDRERLEEIESF 618
+ ++ L+T+ +A +E L + ++ L +Q E+ + E ++++S
Sbjct: 825 QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 619 RKENKDLKEKVNALQAE----LTEKESSLIDLKE---------------HASSLASAGLK 659
+ + E N Q + L EKE+ ++ ++E S+ +
Sbjct: 885 TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 660 RDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQL-DKEASYYRDE 718
++K K+ E +E+ K++ +++ LKK ++ ++++ E + +L KE +
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQETLKK-KLLDQEAKLKKELENTALELSQKEKQFNAKM 1003
Query: 719 CGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA--NLKHNQQLEK 776
AQA + + + +E + + ++ESLT H ++ N ++ K NQQ E+
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKE------QIESLTEVHRRELNDVISIWEKKLNQQAEE 1057
Query: 777 KKNAQLLEEVRRREDSMADNSQHLQI----EELMN---------------ALEKTRQELD 817
+ + +++ +E +A+ Q + + +E MN L + +++L
Sbjct: 1058 LQEIHEI-QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK 1116
Query: 818 ATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEAL-LAAISEKDANIALLELS 876
A + S Q + +AHL L ++ K L+E ++++ + L ++E+D + EL+
Sbjct: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR-KVSELT 1175
Query: 877 ASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKL 911
SK K T EE +LK ++ L+ ++ KL
Sbjct: 1176 -SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Score = 115 bits (287), Expect = 3e-25
Identities = 191/868 (22%), Positives = 376/868 (43%), Gaps = 146/868 (16%)
Query: 149 DLQAQLKELQRENDLLRKELDIKD-SKLGSSMNSIKTFWSPELKKERVLRKEEAA----- 202
D+ ++ ++L +D L KE I+ ++ S++S + +S + ++L++E+
Sbjct: 119 DMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL 178
Query: 203 ---------RMSVLKEQMRVSHEENQHLQLTIQALQDE-------LRTQRDLNHLLQQES 246
R++ L+E++++ + +HLQ A +E L+TQ LL+Q
Sbjct: 179 SQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVS---LLKQRL 235
Query: 247 GN---------------RGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRI 291
N AE FT E E+ E K L L++ ++ E +
Sbjct: 236 RNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLL 295
Query: 292 ETQKQTLNARDESI---------------KKLLEMLQSKGL-------------PSKSLE 323
+ K+T+ + E ++L E+ + K L +K+L
Sbjct: 296 KRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLI 355
Query: 324 DDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRS------QLQPEPAKTKALQ 377
+ E+ + M AE++ + L+ KE+E LR + + + + Q E ++ A +
Sbjct: 356 EQLEQDKGMVIAETK-RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE 414
Query: 378 TVIEMKDT--KIASLERNIR-DLEDEIQMLKANGVLNTEDREEEIKQ-----IEVYKSHS 429
+ + T K R ++ +++++I+ ++ ++E+ + ++V K S
Sbjct: 415 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS 474
Query: 430 KFMKTKIDQL-KQELSKKESELL-ALQTKLETLSNQNSDC--KQHIEVLKESLTAKEQRA 485
+ K+ +L ++EL++KE EL LQT+ Q K E LK S KEQ+
Sbjct: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS-QEKEQQE 533
Query: 486 AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE--VKERKINV 543
++ E++ +K++ L + +L+DL +E T I +++ LE ++E K N
Sbjct: 534 SLALEELEL------QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK-NQ 586
Query: 544 LQKKIENLQEQLRDKDKQLTNL----KDRVKSL--QTDSSNTDTALATLEEALSEKERII 597
+ +L+ + +K++T + K ++SL Q D+ T+ ++ +E E++
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 598 ERLKEQRER--DDRE-----RLEEIESFRKENKDLKE-KVNALQAELTEKESSLIDLKEH 649
E+ ++++E D+E +EE+ E D+K+ ++ +L +EL+E + L+E
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 650 ASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLD 709
S L + D + LE ++++K + + K H + R DQI QL+
Sbjct: 707 LSVLKD---QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV-SIQRTEKALKDQINQLE 762
Query: 710 KEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKI---AELESLTLRHMKDQNKKVA 766
+ QA V+ L +K E E K+ +S T K +++A
Sbjct: 763 LLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLA 822
Query: 767 NLKHN-QQLEKKK---NAQLLEEVRRREDSMADNSQH-LQIEELMNALEKTRQELDATKA 821
L+ LE ++ Q+ E +++D + H +Q+++LM LEK E++
Sbjct: 823 QLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVK 882
Query: 822 RLA---------------STQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEK 866
L T+Q L EKE + +R ++K++ EIL K +S K
Sbjct: 883 SLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI-EILTQK-------LSAK 934
Query: 867 DANIALLELSASKKKKTQEEVMALKREK 894
+ +I +L K K QE+ M ++K
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQK 962
Score = 110 bits (276), Expect = 5e-24
Identities = 163/834 (19%), Positives = 353/834 (42%), Gaps = 145/834 (17%)
Query: 179 MNSIKTFWSPELKKE--------RVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230
+N + + W +L ++ + +E+ ++ LK+++ + E + + I L++
Sbjct: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
Query: 231 ELRTQRDLNHLLQQESGNRGAEHFTIELTEENFR----RLQAEHDRQAKELFLLRKTLEE 286
E Q + LQ++ + A ++ E + +L+ + ++ KE L++ L E
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE 1159
Query: 287 MELRIETQKQTLNARDESIKKLLEMLQS---------KGLPSKSLEDDNERTRRMAEAES 337
+++ E K+ ++ +K E QS K L KSLE + +
Sbjct: 1160 LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDI 1219
Query: 338 QVSHLEVILDQKEKENIHLREE-----LHRRSQLQPEPAKTKALQTVIEMKDTKIASLER 392
E +L+ K E I++ L R S Q K K + +K ++ LE
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE---ALLIKTCTVSELEA 1276
Query: 393 NIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLA 452
+R L +E L + T EE+ QI+ K+ + + T+ + L++E ++
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Query: 453 LQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE------EKESFL 506
++ + L + S+ + ++KE L K+ + L ++ L ++L+ EKE+ +
Sbjct: 1337 KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAI 1396
Query: 507 NKKTKQ-----------LQDLTEEKGTLAGE----------------------------- 526
+ KQ +QDL+ + TL+ E
Sbjct: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQH 1456
Query: 527 ---IRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLK----DRVKSLQTDSSNT 579
+++++ LE+K ++ ++I L+E+L ++K+ LK D ++ SN
Sbjct: 1457 QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Query: 580 DTALAT-------LEEALSEKERIIERLKE-------QRERDDRERLEEIESFRKENKDL 625
+T L + LE+ +++K IE L E Q++ + +E +++++ F++ ++
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK 1576
Query: 626 KEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQL 685
+V E E ++ L+ S+ + + +L+ + ++++ K+EE LE
Sbjct: 1577 DNRVK-------EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE--- 1626
Query: 686 KKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENE-KNDKD 744
R+ E A ++ +L ++A K A +LL ++E E + K +
Sbjct: 1627 ---------DRLESESAAKLAELKRKAEQ------KIAAIKKQLLSQMEEKEEQYKKGTE 1671
Query: 745 KKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEE 804
++EL + ++++ ++V L+ + + ++ L R ++ A Q + +
Sbjct: 1672 SHLSELNT----KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQ--EEAD 1725
Query: 805 LMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMK---QEALL- 860
++KT +E +++ Q++L EKE L + E+ + + EM+ QE L+
Sbjct: 1726 SQGCVQKTYEE------KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK 1779
Query: 861 -----AAISEKDANIALLELSASKKKKTQEEVMA--LKREKDRLVHQLKQQTQN 907
A E + I L+ +K K ++A +++E + Q KQ +N
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833
Score = 97.8 bits (242), Expect = 4e-20
Identities = 153/677 (22%), Positives = 285/677 (42%), Gaps = 91/677 (13%)
Query: 303 ESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEK-------ENIH 355
+ I + + LQ P+++ + + TR + S L+ +E + +
Sbjct: 7 QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66
Query: 356 LR----EELHR--------RSQLQPEPAKTKALQTVIEMK-DTKIASLERNIRDLEDEIQ 402
LR E L R RS + +T + +++ + D+ AS + D++ E +
Sbjct: 67 LRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPP-SDMDSEAE 125
Query: 403 MLKANG-VLNTEDREEEIKQIE----VYKSHSKFMKTKIDQLKQE-------LSKKESEL 450
L N LN E + ++++E Y+ + T L++E LS+ + +
Sbjct: 126 DLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKS 185
Query: 451 LALQTKLETLSNQNSDCKQHI-EVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKK 509
L +L + K+H+ E SL K+Q ++LQT+V L+ RL ++
Sbjct: 186 LRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDV- 244
Query: 510 TKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRV 569
K L L + E D V E +V K +E LQ++++ ++ L K+ +
Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSV--KTLETLQQRVKRQENLLKRCKETI 302
Query: 570 KSLQTDSSNTDTALATLEEALSEKERIIERLKE----------QRERDDRERLEEIESFR 619
+S + + + L+E L E+ + +E++K+ + RD + +E++E +
Sbjct: 303 QSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE--Q 360
Query: 620 KENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLK-RDSKLKSLEIAIEQKKEEC 678
+ + E + L KE + L+ + + G + R+ K KS A E+
Sbjct: 361 DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEE----- 415
Query: 679 SKLEAQLKKAHNIEDDSR-MNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVE 737
LE L A E+ R + E +QIK ++K + +E Q E+ R+ + + V+
Sbjct: 416 --LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTS---EEERISLQQELSRVKQ--EVVD 468
Query: 738 NEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNS 797
K +++IA+L+ L H K+ +K Q+L KK L R ++ M
Sbjct: 469 VMKKSSEEQIAKLQKL---HEKELARK------EQELTKK----LQTREREFQEQMKVAL 515
Query: 798 QHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQE 857
+ Q E L + EK +QE A + + L E E L +L+ E ILE++
Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESS 575
Query: 858 ALLAAISEKDANIAL-LELSASKKKKTQE----------EVMALKREKDRL----VHQLK 902
+ K+ + L + L A K K +E E+ +LK ++D L + LK
Sbjct: 576 LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLK 635
Query: 903 QQTQNRMKLMADNYDDD 919
QQ Q M+ + + + +
Sbjct: 636 QQYQTEMEKLREKCEQE 652
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 130 bits (326), Expect = 8e-30
Identities = 181/876 (20%), Positives = 367/876 (41%), Gaps = 132/876 (15%)
Query: 146 TMLDLQAQLKELQR---ENDLLRKELDIKDSKLGSSMNSIKTFWSP-ELKKERVLRKEEA 201
T + L+A++KE+ + + + EL K KL + +K EL +V +++ A
Sbjct: 915 TKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 974
Query: 202 AR---------MSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAE 252
M+ L E + +E + LQ Q D+L+ + D + L + +
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1034
Query: 253 HFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEML 312
+E + E ++++ + +R ++L K +E + IE KQ L DE +KK +
Sbjct: 1035 VDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL---DEKLKK--KEF 1089
Query: 313 QSKGLPSKSLEDDN----ERTRRMAEAESQVSHLEVILDQK-------EKENIHLREELH 361
+ GL SK +ED+ + +++ E ++++ LE ++ + EK+ L EL
Sbjct: 1090 EMSGLQSK-IEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148
Query: 362 RRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQ 421
S+ E + Q IEM + A ++ RDLE+ +A + + + +
Sbjct: 1149 EISERLEEAGGATSAQ--IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE 1206
Query: 422 IEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAK 481
+ + + ++KQ+L K++SE+ K+E D ++E + ++
Sbjct: 1207 LGEQIDN-------LQRVKQKLEKEKSEM-----KMEI-----DDLASNMETVSKAKGNL 1249
Query: 482 EQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKI 541
E+ L+ ++ ++ + EE++ +N T Q L E G + ++ + ++ R
Sbjct: 1250 EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGK 1309
Query: 542 NVLQKKIENLQEQLRDKDKQLTNLKDRVKS-------LQTDSSNTDTALATLEEALSEKE 594
++IE L+ QL ++ K + L ++S L+ A A L+ A+S+
Sbjct: 1310 QAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKAN 1369
Query: 595 RIIERLKEQRERDDRERLEEIESFRKE----NKDLKEKVNALQAELTEKESSLIDLKEHA 650
+ + + + E D +R EE+E +K+ +D +E V A+ A+ E + L+
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 651 SSLA-------SAGLKRDSKLKSLEIAIEQKKEEC----SKLEAQLKKAHNIEDD----S 695
L +A D K ++ + + + K++C ++LEA K++ ++ +
Sbjct: 1430 EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIK 1489
Query: 696 RMNPEFADQI-------KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIA 748
E DQ+ K L +E S ++ + + L +I K+VE EK++ +
Sbjct: 1490 NAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALE 1549
Query: 749 ELES-------------LTLRHMKDQ-NKKVANLKHNQQLEKKKNAQLLE--------EV 786
E E+ L L +K + ++K+A K+ + +++E E+
Sbjct: 1550 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEI 1609
Query: 787 RRREDSMA--------DNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLA 838
R R D++ N +Q+ + + T+A L TQ L +
Sbjct: 1610 RSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQE 1669
Query: 839 NLR-----IERRKQL--EEILEMKQEALLAAISEKDANIALLELS-------------AS 878
+L+ +ERR L EI E++ S K A LL+ S +
Sbjct: 1670 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1729
Query: 879 KKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
KKK + ++ ++ E + ++ + + + K + D
Sbjct: 1730 TKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITD 1765
Score = 119 bits (298), Expect = 1e-26
Identities = 161/770 (20%), Positives = 337/770 (43%), Gaps = 81/770 (10%)
Query: 191 KKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDEL-----RTQRDLNHLLQQE 245
K + L K EA R L+E+M +E LQL +QA D L R + + +Q E
Sbjct: 862 KTKEELAKTEAKRKE-LEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLE 920
Query: 246 SGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESI 305
+ + E EE L A+ + E L+K ++++EL + ++ +A + +
Sbjct: 921 AKIKEVTE-RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 979
Query: 306 KKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQ 365
K L E + GL +++ + + + EA Q L+ + +++K N + ++ Q
Sbjct: 980 KNLTE--EMAGL-DETIAKLTKEKKALQEAHQQT--LDDLQAEEDKVNTLTKAKIKLEQQ 1034
Query: 366 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425
+ L+ +E + LER R LE ++++ + +T D E + +Q++
Sbjct: 1035 VDD-------LEGSLEQEKKIRMDLERAKRKLEGDLKLAQE----STMDIENDKQQLDEK 1083
Query: 426 KSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRA 485
+F ++ L+ ++ +++ + LQ K++ L + + ++ IE + S E++
Sbjct: 1084 LKKKEF---EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 486 AILQTEVDALRLRLEE--------------KESFLNKKTKQLQDLTEEKGTLAGEIRDM- 530
+ L E++ + RLEE +E+ K + L++ T + A +R
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1200
Query: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
D + +I+ LQ+ + L+++ + ++ +L ++++ N + LE+ L
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQL 1260
Query: 591 S-------EKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 643
S E++R+I L QR R E E +++ + + QA + E
Sbjct: 1261 SEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELK 1320
Query: 644 IDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFAD 703
L+E + ++ S ++ EQ +EE + +A+L++A S+ N E A
Sbjct: 1321 RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE-QEAKAELQRAM-----SKANSEVAQ 1374
Query: 704 QIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNK 763
+ + +A +E +A+ +L + L++ E + K A LE R +
Sbjct: 1375 WRTKYETDAIQRTEELEEAK---KKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVED 1431
Query: 764 KVANLKHNQ----QLEKKKN---------AQLLEEVRRREDSMADNSQHLQIE--ELMNA 808
+ +++ L+KK+ Q EE ++ S+ L E ++ NA
Sbjct: 1432 LMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNA 1491
Query: 809 LEKTRQELDATKARLASTQQSLAEKEAHLA--NLRIERRKQLEEILEMKQEALLAAISEK 866
E++ +L+ K + QQ +++ +A RI +++++ +E ++ L AA+ E
Sbjct: 1492 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEA 1551
Query: 867 DANIALLELSASKKKKTQEEVMALKREKDRLV----HQLKQQTQNRMKLM 912
+A+ LE K + Q E+ +K E DR + ++ Q +N ++++
Sbjct: 1552 EAS---LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIV 1598
Score = 115 bits (289), Expect = 1e-25
Identities = 118/531 (22%), Positives = 240/531 (45%), Gaps = 50/531 (9%)
Query: 419 IKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESL 478
+K E K + MK + ++ K+EL+K E++ L+ K+ TL + +D + ++ +SL
Sbjct: 844 LKSAETEKEMAN-MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902
Query: 479 TAKEQRA-------AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMK 531
E+R L+ ++ + R E++E + T + + L +E L +I D++
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 532 DMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQ-------------TDSSN 578
L E++ + + K++NL E++ D+ + L K+LQ D N
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1022
Query: 579 TDT-ALATLEEALSEKERIIERLKEQR---ERDDRERLEEIESFRKENKDLKEKVNALQA 634
T T A LE+ + + E +E+ K+ R ER R+ +++ ++ D++ L
Sbjct: 1023 TLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDE 1082
Query: 635 ELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDD 694
+L +KE + L+ + G++ K+K L+ IE+ +EE A KA D
Sbjct: 1083 KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142
Query: 695 -SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESL 753
SR E ++++++ S + K +AE ++ L+E + + + +
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202
Query: 754 TLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHL-----QIEELMNA 808
++ + +Q + +K Q+LEK+K+ E++ D +A N + + +E++ A
Sbjct: 1203 SVAELGEQIDNLQRVK--QKLEKEKS-----EMKMEIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 809 LEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDA 868
LE E+ + L + A L E +QL+E ++ L++ +S
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE-----KDTLVSQLSR--G 1308
Query: 869 NIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDD 919
A + K++ +EE+ A K L H L Q +++ L+ + Y+++
Sbjct: 1309 KQAFTQQIEELKRQLEEEIKA----KSALAHAL-QSSRHDCDLLREQYEEE 1354
Score = 112 bits (279), Expect = 2e-24
Identities = 146/650 (22%), Positives = 299/650 (46%), Gaps = 74/650 (11%)
Query: 134 QVPSMLRQVRDSTMLD--LQAQLKELQRENDLLRKELDIKDS------KLGSSMNSIKTF 185
Q+ + RQ+ + L L+ + + DLLR++ + + + S NS
Sbjct: 1315 QIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQ 1374
Query: 186 WSPELKKERVLRKEE--------AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRD 237
W + + + + R EE A R+ +E + + + L+ T Q LQ+E+ D
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE---D 1431
Query: 238 LNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQT 297
L ++ E N ++ + NF ++ AE ++ +E + ++ + T+
Sbjct: 1432 L--MIDVERTNAACA--ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487
Query: 298 L-NARDESIKKLLEMLQSKGLPSKSLEDD-NERTRRMAEAESQVSHLEVILDQKEKENIH 355
+ NA +ES L+ L++ +K+L+ + ++ T ++AE ++ LE I Q E+E
Sbjct: 1488 IKNAYEES----LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 356 LREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDR 415
L+ L ++ E + K L+ +E+ K + ++R I + ++EI +K N + E
Sbjct: 1544 LQAALEE-AEASLEHEEGKILRIQLELNQVK-SEVDRKIAEKDEEIDQMKRNHIRIVESM 1601
Query: 416 EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELL-ALQTKLETLSNQNS------DCK 468
+ + E+ +S + ++ K +++ +L++ E +L A + E L N + D +
Sbjct: 1602 QSTL-DAEI-RSRNDAIRLK-KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQ 1658
Query: 469 QHI-------EVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKG 521
H+ E LKE L E+RA +LQ E++ LR LE+ E ++L D +E
Sbjct: 1659 LHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1718
Query: 522 TLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDT 581
L + ++ K++ L+ I +Q ++ D ++ N +++ K TD++
Sbjct: 1719 LLHTQ---NTSLINTKKK----LETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAE 1771
Query: 582 ALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKES 641
L ++ + ER+ + L EQ +D + RL+E E K K+++ L+A + E E
Sbjct: 1772 ELKKEQDTSAHLERMKKNL-EQTVKDLQHRLDEAEQLAL--KGGKKQIQKLEARVRELEG 1828
Query: 642 SLIDLKEHASSLASAGL-KRDSKLKSLEIAIEQKKEE-------CSKLEAQLK----KAH 689
++ ++ + A GL K + K+K L E+ ++ KL+A++K +A
Sbjct: 1829 E-VESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1887
Query: 690 NIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENE 739
E+ S +N + +++ E + A+++V++L +EV +
Sbjct: 1888 EAEEQSNVN---LSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTK 1934
Score = 101 bits (251), Expect = 4e-21
Identities = 140/653 (21%), Positives = 291/653 (44%), Gaps = 105/653 (16%)
Query: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN 407
+ EKE +++EE + + E AKT+A + +E K+ +L + DL+ ++Q +A+
Sbjct: 848 ETEKEMANMKEEFEKTKE---ELAKTEAKRKELE---EKMVTLMQEKNDLQLQVQA-EAD 900
Query: 408 GVLNTEDR-----------EEEIKQI-------EVYKSHSKFMKTKID----QLKQE--- 442
+ + E+R E +IK++ E + K K++ +LK++
Sbjct: 901 SLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 960
Query: 443 ----LSKKESELLALQTKLETLSNQNSDCKQHIEVL----KESLTAKEQRAAILQTEVDA 494
L+K E E A + K++ L+ + + + I L K A +Q LQ E D
Sbjct: 961 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDK 1020
Query: 495 L------RLRLEEK----ESFLNKKTKQLQDLTEEKGTLAGEIR--------------DM 530
+ +++LE++ E L ++ K DL K L G+++ +
Sbjct: 1021 VNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL 590
+ L+ KE +++ LQ KIE+ Q K++ L+ R++ L+ + + A E+
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 591 SEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDL-KEH 649
S+ R +E + E+ E +IE +K + ++ L+ + E++ L K+H
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1200
Query: 650 ASSLASAGLKRDSKLKSLEIAIEQKKEE--------CSKLEAQLKKAHNIEDDSRMNPEF 701
A S+A G + D+ L+ ++ +E++K E S +E K N+E R +
Sbjct: 1201 ADSVAELGEQIDN-LQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQ 1259
Query: 702 ADQIKQLDKE-----------ASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAEL 750
+IK ++E + + E G+ ++D ++ ++ K ++I EL
Sbjct: 1260 LSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319
Query: 751 ESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMAD--------NSQHLQ- 801
+ R ++++ K + L H Q + L E+ +++ A+ NS+ Q
Sbjct: 1320 K----RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQW 1375
Query: 802 -IEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALL 860
+ +A+++T +EL+ K +LA Q AE+ N + ++ ++ L+ + E L+
Sbjct: 1376 RTKYETDAIQRT-EELEEAKKKLAQRLQD-AEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1433
Query: 861 AAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMA 913
+ +A A L+ KK++ ++++A ++K H + +Q + ++
Sbjct: 1434 IDVERTNAACAALD----KKQRNFDKILAEWKQKCEETHAELEASQKESRSLS 1482
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 127 bits (320), Expect = 4e-29
Identities = 188/846 (22%), Positives = 371/846 (43%), Gaps = 132/846 (15%)
Query: 128 SHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWS 187
S+ Q+ +QVR+ ++A++ L++EN +LR + ++ N +++ S
Sbjct: 397 SYQETQQMQMKFQQVREQ----MEAEIAHLKQENGILR-------DAVSNTTNQLESKQS 445
Query: 188 PELKKERVLRKEEAARMSVL--------KEQMRVSHEENQHLQLTIQALQDELRTQRDLN 239
EL K LR++ A ++ L +E+++ + E QL +Q + E R +
Sbjct: 446 AELNK---LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE--- 499
Query: 240 HLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLN 299
+Q R AEH E + LQ++ + E+ L L + + + +Q L
Sbjct: 500 --VQSYIRKRTAEH------EAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLM 551
Query: 300 ARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREE 359
ES +K + +S + + + + NE + A+ Q H ++ L EE
Sbjct: 552 QLMESEQKRVNKEESLQMQVQDILEQNEALK----AQIQQFHSQIAAQTSASV---LAEE 604
Query: 360 LHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKA-----NGVLNTE- 413
LH+ + + + K + + + ++ S E ++D+++ +LKA + N +
Sbjct: 605 LHK--VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQA 662
Query: 414 --DREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQ----------TKLETLS 461
E E Q VY K ++ +QL+ E+S K E L KL+TL
Sbjct: 663 AAAHELEKMQQSVYVKDDK-IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
Query: 462 NQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLN-------KKTKQLQ 514
++ + K +E +++ + K+++ ++ ++ +++ KE LN TK++Q
Sbjct: 722 SEQPN-KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 515 DLTEEKG---TLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKS 571
DL ++ + A + ++K ++ K+ KI +++ +E ++ +K+K + +LK +K+
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 572 LQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER--LEEIESFRKENKDLKEKV 629
L+ + N A S+ + + LK + E+ + + LEE E KDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE------KDLANTG 894
Query: 630 NALQAELTEKESSLIDLKEHASSLASAGLKR---DSKLKSLEIAIEQKKEECSKLEAQLK 686
LQ E ES LK H +A LK S+ + LEI +++K+ E +LEA LK
Sbjct: 895 KWLQDLQEENES----LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 687 --------KAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVEN 738
K ++D N F QI+QL K+ +Y + E LL+++ E
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIEQL-KQQNYQQASSFPPHEE---LLKVISE--- 1003
Query: 739 EKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQ 798
++K+I+ L + ++ +LK + ++KKN L E+ +++A +
Sbjct: 1004 ----REKEISGLWN-----------ELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 799 HLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIER-----RKQLEEIL- 852
LQ +++ ++ +Q+++A + + L K + +NL K+ +E +
Sbjct: 1049 MLQ-DKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
Query: 853 ----EMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNR 908
+ + L + E D LL+L K K E + ++ R V +Q +N+
Sbjct: 1108 GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSV----EQEENK 1163
Query: 909 MKLMAD 914
K+ D
Sbjct: 1164 WKVKVD 1169
Score = 117 bits (294), Expect = 4e-26
Identities = 162/788 (20%), Positives = 342/788 (43%), Gaps = 138/788 (17%)
Query: 155 KELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVS 214
K++++ D L E D +L S +K +++ L K E ++ L + +
Sbjct: 614 KQIKQTEDSLASERD----RLTSKEEELK-----DIQNMNFLLKAEVQKLQALANEQAAA 664
Query: 215 HEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQA 274
E + +Q ++ D++R L LQ E N+ E F+ L ++
Sbjct: 665 AHELEKMQQSVYVKDDKIRL---LEEQLQHEISNK----------MEEFKILNDQNKALK 711
Query: 275 KELFLLRKTLEEMELR--IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRM 332
E+ L+ + E + +E ++ + +DE +K + E+L++ + + E++ R
Sbjct: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRT- 770
Query: 333 AEAESQVSHLEVILDQKEKEN-----IHLREELHRRSQLQPEPAKTKALQTVIEMKDTKI 387
S + + D K K+N L EEL + + + K K+++ ++E + K+
Sbjct: 771 ----ENSSLTKEVQDLKAKQNDQVSFASLVEEL--KKVIHEKDGKIKSVEELLEAELLKV 824
Query: 388 ASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKE 447
A+ E+ ++DL+ EI+ LK EEI +++ K+ + +K+ +L+ L KE
Sbjct: 825 ANKEKTVQDLKQEIKALK-----------EEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
Query: 448 SELLALQTKLET--------------LSNQNSDCKQHIEV-----LKESLTAK--EQRAA 486
++ ++ LE L +N K H++ LKE+ +A E+
Sbjct: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEI 933
Query: 487 IL---QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMK------------ 531
+L + E+ L L+E+ES L+ KT+ LQD+ +E +I +K
Sbjct: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 993
Query: 532 --DMLEV---KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATL 586
++L+V +E++I+ L ++++L++ + + K+ +L+++ + ALA+
Sbjct: 994 HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK-------NWEAMEALAST 1046
Query: 587 EEALSEKERIIERLKEQR----ERDDRERLEEI----------------ESFRKENKDL- 625
E+ L +K + ++Q+ E + +E L+++ F K+ K+
Sbjct: 1047 EKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1106
Query: 626 -----KEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQ------- 673
E+V L+ +L E + L+ S + + L+ L+ ++EQ
Sbjct: 1107 AGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKV 1166
Query: 674 KKEECSKLEAQLKKAHNIEDDS--RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
K +E K Q++ + + R+ E D I+ L +E + E KA+ E +
Sbjct: 1167 KVDESHKTIKQMQSSFTSSEQELERLRSENKD-IENLRREREHLEMELEKAEMERSTYVT 1225
Query: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
++E+++ + KK+ + S +R ++ N A L N+ L K + E+ R++
Sbjct: 1226 EVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQL--NETLTKLRT----EQNERQKV 1279
Query: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEI 851
+ + +E + + + K + + S + +EKE +L + QL+++
Sbjct: 1280 AGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLN-QTVTQLQQL 1338
Query: 852 LEMKQEAL 859
L+ + L
Sbjct: 1339 LQAVNQQL 1346
Score = 73.2 bits (178), Expect = 1e-12
Identities = 103/538 (19%), Positives = 220/538 (40%), Gaps = 76/538 (14%)
Query: 150 LQAQLKELQRENDLLRKELD-IKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLK 208
L +LK++ E D K ++ + +++L N KT +LK+E KEE + + K
Sbjct: 795 LVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV--QDLKQEIKALKEEIGNVQLEK 852
Query: 209 EQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEEN---FRR 265
Q + Q LQ ++ ++++ T + + +++ N G + +L EEN
Sbjct: 853 AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG--KWLQDLQEENESLKAH 910
Query: 266 LQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD 325
+Q KE + EE+E+ ++ ++ L + +K+ L SK + ++D+
Sbjct: 911 VQEVAQHNLKEASSASQ-FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE 969
Query: 326 NERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDT 385
N+ + SQ+ L+ ++ + S P + L VI ++
Sbjct: 970 NKLFK------SQIEQLK-------------QQNYQQASSFPPH----EELLKVISEREK 1006
Query: 386 KIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSK 445
+I+ L + L+D ++ + N + RE+ + +E S K ++ K+++ +E +
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKK---NNDLREKNWEAMEALASTEKMLQDKVNKTSKE-RQ 1062
Query: 446 KESELLALQTK---------------------LETLSNQNSDC------KQHIEVLKESL 478
++ E + L+ K L + +C + ++VL+ L
Sbjct: 1063 QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL 1122
Query: 479 TAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKE 538
++ +LQ E + + L E E L K + ++ E K ++
Sbjct: 1123 KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQ----------EENKWKVKVDESH 1172
Query: 539 RKINVLQKKI---ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKER 595
+ I +Q E E+LR ++K + NL+ + L+ + + +T + E +
Sbjct: 1173 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKD 1232
Query: 596 IIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSL 653
++ L+++ + E + + E L E + L+ E E++ DL + SL
Sbjct: 1233 LLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL 1290
Score = 64.7 bits (156), Expect = 4e-10
Identities = 123/610 (20%), Positives = 246/610 (40%), Gaps = 103/610 (16%)
Query: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN 407
+KE +N +L E S+ P K L + ++D ++A + N+ + ++ K
Sbjct: 64 KKEIQNGNLHES---DSESVPRDFK---LSDALAVEDDQVAPVPLNVVETSSSVRERKKK 117
Query: 408 GVLNTEDREEEIKQIEVYKSH--SKFMKTKIDQL---KQELSKKESELLALQTKLETLSN 462
E +++ + + +V K SK K++ + KQ E+ + + N
Sbjct: 118 -----EKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKN 172
Query: 463 QNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQL---QDLTEE 519
+ D + +E L + +K Q A L E ++K S +KT+ + + L
Sbjct: 173 GSDDQDKKVETLM--VPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHA 230
Query: 520 KGTL-------AGEIRDMKDMLEV-KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKS 571
+ + + D ++++++ K ++ +QK + DK+ KD + S
Sbjct: 231 TTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLS 290
Query: 572 LQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNA 631
L+T + D AL + + L EK +I+ ++ +K +K ++
Sbjct: 291 LKTMMFSEDEALCVV-DLLKEKSGVIQ-----------------DALKKSSKG---ELTT 329
Query: 632 LQAELTEKESSLIDLKEHASSLASAGLKRDSKL----KSLEIAIEQKKEECSKLEAQLKK 687
L +L EK+ L +KE A++ + ++ + + I + K+ LE K
Sbjct: 330 LIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE----K 385
Query: 688 AHNI---------EDDSRMNPEFADQIKQLDKEASYYRDECG---------------KAQ 723
HN+ ++ +M +F +Q++ E ++ + E G K
Sbjct: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
Query: 724 AEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLL 783
AE+++L + + NE +K K+ + E K+ + LK Q +++ ++
Sbjct: 446 AELNKLRQDYARLVNELTEKTGKLQQEEV----QKKNAEQAATQLKVQLQEAERRWEEVQ 501
Query: 784 EEVRRREDSMADNSQHLQI-----EELMNALEKTRQELDATKARLASTQQSLAEKEAHLA 838
+R+R Q LQ E + +L + +K +L L E E
Sbjct: 502 SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
Query: 839 NLRIERRKQLEEILEMKQEALLAAISEKDANIA-----------LLELSASKKKKTQEEV 887
N + Q+++ILE + EAL A I + + IA L ++ A K K+ ++
Sbjct: 562 NKEESLQMQVQDILE-QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTE 620
Query: 888 MALKREKDRL 897
+L E+DRL
Sbjct: 621 DSLASERDRL 630
Score = 58.5 bits (140), Expect = 3e-08
Identities = 98/498 (19%), Positives = 223/498 (44%), Gaps = 60/498 (12%)
Query: 120 QHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSM 179
QH SS ++ +L++ +++ + L+A LKE RE+DL K ++D +
Sbjct: 916 QHNLKEASSASQFEELEIVLKE-KENELKRLEAMLKE--RESDLSSKTQLLQDVQ----- 967
Query: 180 NSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRD-L 238
+ K F S ++++ + ++A+ +E ++V E + I L +EL + +D +
Sbjct: 968 DENKLFKS-QIEQLKQQNYQQASSFPPHEELLKVISEREKE----ISGLWNELDSLKDAV 1022
Query: 239 NHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTL 298
H Q++ N +L E+N+ ++A + + KT +E + ++E + L
Sbjct: 1023 EH--QRKKNN--------DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE--L 1070
Query: 299 NARDESIKKLLEMLQ-SKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLR 357
A+ E +KKL + L E+ + A + S +L+ K KE
Sbjct: 1071 EAK-EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKE----A 1125
Query: 358 EELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREE 417
+E+H QL+ E K+ +T + + L+R++ E++ ++ ++ +
Sbjct: 1126 DEMHTLLQLECEKYKSVLAET-----EGILQKLQRSVEQEENKWKV-------KVDESHK 1173
Query: 418 EIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKES 477
IKQ++ + S+ ++ +++ E L+ +LE + S + LK+
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDL 1233
Query: 478 LTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVK 537
LT +++ +E L ++ LN+ +L+ E+ +AG+
Sbjct: 1234 LTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGD----------- 1282
Query: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERII 597
++ Q+ +E +Q ++ T +++ S +T+SS +T +L + +++ ++++
Sbjct: 1283 ---LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLL 1339
Query: 598 ERLKEQ--RERDDRERLE 613
+ + +Q +E++ + LE
Sbjct: 1340 QAVNQQLTKEKEHYQVLE 1357
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 127 bits (320), Expect = 4e-29
Identities = 182/846 (21%), Positives = 366/846 (43%), Gaps = 116/846 (13%)
Query: 128 SHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWS 187
S+ Q+ +QVR+ ++A++ L++EN +LR + ++ N +++ S
Sbjct: 397 SYQETQQMQMKFQQVREQ----MEAEIAHLKQENGILR-------DAVSNTTNQLESKQS 445
Query: 188 PELKKERVLRKEEAARMSVL--------KEQMRVSHEENQHLQLTIQALQDELRTQRDLN 239
EL K LR++ A ++ L +E+++ + E QL +Q + E R +
Sbjct: 446 AELNK---LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE--- 499
Query: 240 HLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLN 299
+Q R AEH E + LQ++ + E+ L L + + + +Q L
Sbjct: 500 --VQSYIRKRTAEH------EAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLM 551
Query: 300 ARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREE 359
ES +K + +S + + + + NE + A+ Q H ++ L EE
Sbjct: 552 QLMESEQKRVNKEESLQMQVQDILEQNEALK----AQIQQFHSQIAAQTSASV---LAEE 604
Query: 360 LHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKA-----NGVLNTE- 413
LH+ + + + K + + + ++ S E ++D+++ +LKA + N +
Sbjct: 605 LHK--VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQA 662
Query: 414 --DREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQ----------TKLETLS 461
E E Q VY K ++ +QL+ E+S K E L KL+TL
Sbjct: 663 AAAHELEKMQQSVYVKDDK-IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
Query: 462 NQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLN-------KKTKQLQ 514
++ + K +E +++ + K+++ ++ ++ +++ KE LN TK++Q
Sbjct: 722 SEQPN-KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 515 DLTEEKG---TLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKS 571
DL ++ + A + ++K ++ K+ KI +++ +E ++ +K+K + +LK +K+
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 572 LQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER--LEEIESFRKENKDLKEKV 629
L+ + N A S+ + + LK + E+ + + LEE E KDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE------KDLANTG 894
Query: 630 NALQAELTEKESSLIDLKEHASSLASAGLKR---DSKLKSLEIAIEQKKEECSKLEAQLK 686
LQ E ES LK H +A LK S+ + LEI +++K+ E +LEA LK
Sbjct: 895 KWLQDLQEENES----LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 687 --------KAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVEN 738
K ++D N F QI+QL K+ +Y + E LL+++ E E
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIEQL-KQQNYQQASSFPPHEE---LLKVISEREK 1006
Query: 739 EKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEV------------ 786
E + ++ L+ K N++ ++ + K+ +L +V
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWL 1066
Query: 787 ----RRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRI 842
++ ++ MA S +++ L + L++ + + + LAE E L L+
Sbjct: 1067 HGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ- 1125
Query: 843 ERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLK 902
+Q E ++K + I + ++ E + + +++ L+RE++ L +L+
Sbjct: 1126 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1185
Query: 903 QQTQNR 908
+ R
Sbjct: 1186 KAEMER 1191
Score = 115 bits (289), Expect = 1e-25
Identities = 144/720 (20%), Positives = 313/720 (43%), Gaps = 109/720 (15%)
Query: 155 KELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVS 214
K++++ D L E D +L S +K +++ L K E ++ L + +
Sbjct: 614 KQIKQTEDSLASERD----RLTSKEEELK-----DIQNMNFLLKAEVQKLQALANEQAAA 664
Query: 215 HEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQA 274
E + +Q ++ D++R L LQ E N+ E F+ L ++
Sbjct: 665 AHELEKMQQSVYVKDDKIRL---LEEQLQHEISNK----------MEEFKILNDQNKALK 711
Query: 275 KELFLLRKTLEEMELR--IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRM 332
E+ L+ + E + +E ++ + +DE +K + E+L++ + + E++ R
Sbjct: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRT- 770
Query: 333 AEAESQVSHLEVILDQKEKEN-----IHLREELHRRSQLQPEPAKTKALQTVIEMKDTKI 387
S + + D K K+N L EEL + + + K K+++ ++E + K+
Sbjct: 771 ----ENSSLTKEVQDLKAKQNDQVSFASLVEEL--KKVIHEKDGKIKSVEELLEAELLKV 824
Query: 388 ASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKE 447
A+ E+ ++DL+ EI+ LK EEI +++ K+ + +K+ +L+ L KE
Sbjct: 825 ANKEKTVQDLKQEIKALK-----------EEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
Query: 448 SELLALQTKLET--------------LSNQNSDCKQHIEV-----LKESLTAK--EQRAA 486
++ ++ LE L +N K H++ LKE+ +A E+
Sbjct: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEI 933
Query: 487 IL---QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMK------------ 531
+L + E+ L L+E+ES L+ KT+ LQD+ +E +I +K
Sbjct: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 993
Query: 532 --DMLEV---KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTAL--- 583
++L+V +E++I+ L ++++L++ + + K+ + +V++++ ++ L
Sbjct: 994 HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPK 1053
Query: 584 ATLEEALSEKERIIERLKEQRE-RDDRERLEEIESFRKENKDLKEKVNALQAELTEKESS 642
++ LS E + K+ +E EE++ + K+ E LQ E + +S
Sbjct: 1054 VSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1113
Query: 643 LIDLKEHASSLASAGLKRDSK-----------LKSLEIAIEQKKEECSKLEAQLKKAHNI 691
L + + L + + ++K +K ++ + ++E +L ++ K N+
Sbjct: 1114 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENL 1173
Query: 692 EDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELE 751
R ++++ + E S Y E + +A+++ E L ++ E+N++ K +L
Sbjct: 1174 R---REREHLEMELEKAEMERSTYVTEVRELKAQLN---ETLTKLRTEQNERQKVAGDLH 1227
Query: 752 SLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEK 811
Q+K V +E + E + S++ N Q+++L+ A+ +
Sbjct: 1228 KAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQ 1287
Score = 72.4 bits (176), Expect = 2e-12
Identities = 110/518 (21%), Positives = 230/518 (44%), Gaps = 66/518 (12%)
Query: 150 LQAQLKELQRENDLLRKELD-IKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLK 208
L +LK++ E D K ++ + +++L N KT +LK+E KEE + + K
Sbjct: 795 LVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV--QDLKQEIKALKEEIGNVQLEK 852
Query: 209 EQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEEN------ 262
Q + Q LQ ++ ++++ T + + +++ N G + +L EEN
Sbjct: 853 AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG--KWLQDLQEENESLKAH 910
Query: 263 -----------------FRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTL-NARDES 304
F L+ + EL L L+E E + ++ Q L + +DE+
Sbjct: 911 VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN 970
Query: 305 --IKKLLEMLQSKGL-PSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELH 361
K +E L+ + + S E + ++E E ++S L LD + H R++ +
Sbjct: 971 KLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN 1030
Query: 362 RRSQLQPEPAKTKALQTVIEMKDTKIA-----SLERNIRDLEDEIQMLKANGVLNTEDRE 416
R Q Q E + +A + V++ K++ S + E + + A + E +
Sbjct: 1031 ERQQ-QVEAVELEA-KEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV 1088
Query: 417 EEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE 476
E K E + H+ ++ + ++ K L++ E L LQ +E N K ++V +
Sbjct: 1089 LEHKLKEADEMHT-LLQLECEKYKSVLAETEGILQKLQRSVEQEEN-----KWKVKVDES 1142
Query: 477 SLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTK-----QLQDLTEEKGTLAGEIRDMK 531
T K+ +++ +E + RLR E K+ ++ + +L+ E+ T E+R++K
Sbjct: 1143 HKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELK 1202
Query: 532 DML---------EVKERK-----INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSS 577
L E ER+ ++ Q+ +E +Q ++ T +++ S +T+SS
Sbjct: 1203 AQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESS 1262
Query: 578 NTDTALATLEEALSEKERIIERLKEQ--RERDDRERLE 613
+T +L + +++ +++++ + +Q +E++ + LE
Sbjct: 1263 EKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
Score = 64.7 bits (156), Expect = 4e-10
Identities = 123/610 (20%), Positives = 246/610 (40%), Gaps = 103/610 (16%)
Query: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN 407
+KE +N +L E S+ P K L + ++D ++A + N+ + ++ K
Sbjct: 64 KKEIQNGNLHES---DSESVPRDFK---LSDALAVEDDQVAPVPLNVVETSSSVRERKKK 117
Query: 408 GVLNTEDREEEIKQIEVYKSH--SKFMKTKIDQL---KQELSKKESELLALQTKLETLSN 462
E +++ + + +V K SK K++ + KQ E+ + + N
Sbjct: 118 -----EKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKN 172
Query: 463 QNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQL---QDLTEE 519
+ D + +E L + +K Q A L E ++K S +KT+ + + L
Sbjct: 173 GSDDQDKKVETLM--VPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHA 230
Query: 520 KGTL-------AGEIRDMKDMLEV-KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKS 571
+ + + D ++++++ K ++ +QK + DK+ KD + S
Sbjct: 231 TTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLS 290
Query: 572 LQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNA 631
L+T + D AL + + L EK +I+ ++ +K +K ++
Sbjct: 291 LKTMMFSEDEALCVV-DLLKEKSGVIQ-----------------DALKKSSKG---ELTT 329
Query: 632 LQAELTEKESSLIDLKEHASSLASAGLKRDSKL----KSLEIAIEQKKEECSKLEAQLKK 687
L +L EK+ L +KE A++ + ++ + + I + K+ LE K
Sbjct: 330 LIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE----K 385
Query: 688 AHNI---------EDDSRMNPEFADQIKQLDKEASYYRDECG---------------KAQ 723
HN+ ++ +M +F +Q++ E ++ + E G K
Sbjct: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
Query: 724 AEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLL 783
AE+++L + + NE +K K+ + E K+ + LK Q +++ ++
Sbjct: 446 AELNKLRQDYARLVNELTEKTGKLQQEEV----QKKNAEQAATQLKVQLQEAERRWEEVQ 501
Query: 784 EEVRRREDSMADNSQHLQI-----EELMNALEKTRQELDATKARLASTQQSLAEKEAHLA 838
+R+R Q LQ E + +L + +K +L L E E
Sbjct: 502 SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
Query: 839 NLRIERRKQLEEILEMKQEALLAAISEKDANIA-----------LLELSASKKKKTQEEV 887
N + Q+++ILE + EAL A I + + IA L ++ A K K+ ++
Sbjct: 562 NKEESLQMQVQDILE-QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTE 620
Query: 888 MALKREKDRL 897
+L E+DRL
Sbjct: 621 DSLASERDRL 630
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 127 bits (320), Expect = 4e-29
Identities = 188/846 (22%), Positives = 371/846 (43%), Gaps = 132/846 (15%)
Query: 128 SHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWS 187
S+ Q+ +QVR+ ++A++ L++EN +LR + ++ N +++ S
Sbjct: 397 SYQETQQMQMKFQQVREQ----MEAEIAHLKQENGILR-------DAVSNTTNQLESKQS 445
Query: 188 PELKKERVLRKEEAARMSVL--------KEQMRVSHEENQHLQLTIQALQDELRTQRDLN 239
EL K LR++ A ++ L +E+++ + E QL +Q + E R +
Sbjct: 446 AELNK---LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE--- 499
Query: 240 HLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLN 299
+Q R AEH E + LQ++ + E+ L L + + + +Q L
Sbjct: 500 --VQSYIRKRTAEH------EAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLM 551
Query: 300 ARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREE 359
ES +K + +S + + + + NE + A+ Q H ++ L EE
Sbjct: 552 QLMESEQKRVNKEESLQMQVQDILEQNEALK----AQIQQFHSQIAAQTSASV---LAEE 604
Query: 360 LHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKA-----NGVLNTE- 413
LH+ + + + K + + + ++ S E ++D+++ +LKA + N +
Sbjct: 605 LHK--VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQA 662
Query: 414 --DREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQ----------TKLETLS 461
E E Q VY K ++ +QL+ E+S K E L KL+TL
Sbjct: 663 AAAHELEKMQQSVYVKDDK-IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
Query: 462 NQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLN-------KKTKQLQ 514
++ + K +E +++ + K+++ ++ ++ +++ KE LN TK++Q
Sbjct: 722 SEQPN-KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 515 DLTEEKG---TLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKS 571
DL ++ + A + ++K ++ K+ KI +++ +E ++ +K+K + +LK +K+
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 572 LQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRER--LEEIESFRKENKDLKEKV 629
L+ + N A S+ + + LK + E+ + + LEE E KDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE------KDLANTG 894
Query: 630 NALQAELTEKESSLIDLKEHASSLASAGLKR---DSKLKSLEIAIEQKKEECSKLEAQLK 686
LQ E ES LK H +A LK S+ + LEI +++K+ E +LEA LK
Sbjct: 895 KWLQDLQEENES----LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK 950
Query: 687 --------KAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVEN 738
K ++D N F QI+QL K+ +Y + E LL+++ E
Sbjct: 951 ERESDLSSKTQLLQDVQDENKLFKSQIEQL-KQQNYQQASSFPPHEE---LLKVISE--- 1003
Query: 739 EKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQ 798
++K+I+ L + ++ +LK + ++KKN L E+ +++A +
Sbjct: 1004 ----REKEISGLWN-----------ELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 799 HLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIER-----RKQLEEIL- 852
LQ +++ ++ +Q+++A + + L K + +NL K+ +E +
Sbjct: 1049 MLQ-DKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
Query: 853 ----EMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNR 908
+ + L + E D LL+L K K E + ++ R V +Q +N+
Sbjct: 1108 GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSV----EQEENK 1163
Query: 909 MKLMAD 914
K+ D
Sbjct: 1164 WKVKVD 1169
Score = 117 bits (294), Expect = 4e-26
Identities = 162/788 (20%), Positives = 342/788 (43%), Gaps = 138/788 (17%)
Query: 155 KELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVS 214
K++++ D L E D +L S +K +++ L K E ++ L + +
Sbjct: 614 KQIKQTEDSLASERD----RLTSKEEELK-----DIQNMNFLLKAEVQKLQALANEQAAA 664
Query: 215 HEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQA 274
E + +Q ++ D++R L LQ E N+ E F+ L ++
Sbjct: 665 AHELEKMQQSVYVKDDKIRL---LEEQLQHEISNK----------MEEFKILNDQNKALK 711
Query: 275 KELFLLRKTLEEMELR--IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRM 332
E+ L+ + E + +E ++ + +DE +K + E+L++ + + E++ R
Sbjct: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRT- 770
Query: 333 AEAESQVSHLEVILDQKEKEN-----IHLREELHRRSQLQPEPAKTKALQTVIEMKDTKI 387
S + + D K K+N L EEL + + + K K+++ ++E + K+
Sbjct: 771 ----ENSSLTKEVQDLKAKQNDQVSFASLVEEL--KKVIHEKDGKIKSVEELLEAELLKV 824
Query: 388 ASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKE 447
A+ E+ ++DL+ EI+ LK EEI +++ K+ + +K+ +L+ L KE
Sbjct: 825 ANKEKTVQDLKQEIKALK-----------EEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
Query: 448 SELLALQTKLET--------------LSNQNSDCKQHIEV-----LKESLTAK--EQRAA 486
++ ++ LE L +N K H++ LKE+ +A E+
Sbjct: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEI 933
Query: 487 IL---QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMK------------ 531
+L + E+ L L+E+ES L+ KT+ LQD+ +E +I +K
Sbjct: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 993
Query: 532 --DMLEV---KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATL 586
++L+V +E++I+ L ++++L++ + + K+ +L+++ + ALA+
Sbjct: 994 HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK-------NWEAMEALAST 1046
Query: 587 EEALSEKERIIERLKEQR----ERDDRERLEEI----------------ESFRKENKDL- 625
E+ L +K + ++Q+ E + +E L+++ F K+ K+
Sbjct: 1047 EKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1106
Query: 626 -----KEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQ------- 673
E+V L+ +L E + L+ S + + L+ L+ ++EQ
Sbjct: 1107 AGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKV 1166
Query: 674 KKEECSKLEAQLKKAHNIEDDS--RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
K +E K Q++ + + R+ E D I+ L +E + E KA+ E +
Sbjct: 1167 KVDESHKTIKQMQSSFTSSEQELERLRSENKD-IENLRREREHLEMELEKAEMERSTYVT 1225
Query: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
++E+++ + KK+ + S +R ++ N A L N+ L K + E+ R++
Sbjct: 1226 EVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQL--NETLTKLRT----EQNERQKV 1279
Query: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEI 851
+ + +E + + + K + + S + +EKE +L + QL+++
Sbjct: 1280 AGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLN-QTVTQLQQL 1338
Query: 852 LEMKQEAL 859
L+ + L
Sbjct: 1339 LQAVNQQL 1346
Score = 73.2 bits (178), Expect = 1e-12
Identities = 103/538 (19%), Positives = 220/538 (40%), Gaps = 76/538 (14%)
Query: 150 LQAQLKELQRENDLLRKELD-IKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLK 208
L +LK++ E D K ++ + +++L N KT +LK+E KEE + + K
Sbjct: 795 LVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV--QDLKQEIKALKEEIGNVQLEK 852
Query: 209 EQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEEN---FRR 265
Q + Q LQ ++ ++++ T + + +++ N G + +L EEN
Sbjct: 853 AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG--KWLQDLQEENESLKAH 910
Query: 266 LQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD 325
+Q KE + EE+E+ ++ ++ L + +K+ L SK + ++D+
Sbjct: 911 VQEVAQHNLKEASSASQ-FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE 969
Query: 326 NERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDT 385
N+ + SQ+ L+ ++ + S P + L VI ++
Sbjct: 970 NKLFK------SQIEQLK-------------QQNYQQASSFPPH----EELLKVISEREK 1006
Query: 386 KIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSK 445
+I+ L + L+D ++ + N + RE+ + +E S K ++ K+++ +E +
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKK---NNDLREKNWEAMEALASTEKMLQDKVNKTSKE-RQ 1062
Query: 446 KESELLALQTK---------------------LETLSNQNSDC------KQHIEVLKESL 478
++ E + L+ K L + +C + ++VL+ L
Sbjct: 1063 QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL 1122
Query: 479 TAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKE 538
++ +LQ E + + L E E L K + ++ E K ++
Sbjct: 1123 KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQ----------EENKWKVKVDESH 1172
Query: 539 RKINVLQKKI---ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKER 595
+ I +Q E E+LR ++K + NL+ + L+ + + +T + E +
Sbjct: 1173 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKD 1232
Query: 596 IIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSL 653
++ L+++ + E + + E L E + L+ E E++ DL + SL
Sbjct: 1233 LLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL 1290
Score = 64.7 bits (156), Expect = 4e-10
Identities = 123/610 (20%), Positives = 246/610 (40%), Gaps = 103/610 (16%)
Query: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKAN 407
+KE +N +L E S+ P K L + ++D ++A + N+ + ++ K
Sbjct: 64 KKEIQNGNLHES---DSESVPRDFK---LSDALAVEDDQVAPVPLNVVETSSSVRERKKK 117
Query: 408 GVLNTEDREEEIKQIEVYKSH--SKFMKTKIDQL---KQELSKKESELLALQTKLETLSN 462
E +++ + + +V K SK K++ + KQ E+ + + N
Sbjct: 118 -----EKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKN 172
Query: 463 QNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQL---QDLTEE 519
+ D + +E L + +K Q A L E ++K S +KT+ + + L
Sbjct: 173 GSDDQDKKVETLM--VPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHA 230
Query: 520 KGTL-------AGEIRDMKDMLEV-KERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKS 571
+ + + D ++++++ K ++ +QK + DK+ KD + S
Sbjct: 231 TTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLS 290
Query: 572 LQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNA 631
L+T + D AL + + L EK +I+ ++ +K +K ++
Sbjct: 291 LKTMMFSEDEALCVV-DLLKEKSGVIQ-----------------DALKKSSKG---ELTT 329
Query: 632 LQAELTEKESSLIDLKEHASSLASAGLKRDSKL----KSLEIAIEQKKEECSKLEAQLKK 687
L +L EK+ L +KE A++ + ++ + + I + K+ LE K
Sbjct: 330 LIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE----K 385
Query: 688 AHNI---------EDDSRMNPEFADQIKQLDKEASYYRDECG---------------KAQ 723
HN+ ++ +M +F +Q++ E ++ + E G K
Sbjct: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
Query: 724 AEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLL 783
AE+++L + + NE +K K+ + E K+ + LK Q +++ ++
Sbjct: 446 AELNKLRQDYARLVNELTEKTGKLQQEEV----QKKNAEQAATQLKVQLQEAERRWEEVQ 501
Query: 784 EEVRRREDSMADNSQHLQI-----EELMNALEKTRQELDATKARLASTQQSLAEKEAHLA 838
+R+R Q LQ E + +L + +K +L L E E
Sbjct: 502 SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRV 561
Query: 839 NLRIERRKQLEEILEMKQEALLAAISEKDANIA-----------LLELSASKKKKTQEEV 887
N + Q+++ILE + EAL A I + + IA L ++ A K K+ ++
Sbjct: 562 NKEESLQMQVQDILE-QNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTE 620
Query: 888 MALKREKDRL 897
+L E+DRL
Sbjct: 621 DSLASERDRL 630
Score = 58.5 bits (140), Expect = 3e-08
Identities = 98/498 (19%), Positives = 223/498 (44%), Gaps = 60/498 (12%)
Query: 120 QHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSM 179
QH SS ++ +L++ +++ + L+A LKE RE+DL K ++D +
Sbjct: 916 QHNLKEASSASQFEELEIVLKE-KENELKRLEAMLKE--RESDLSSKTQLLQDVQ----- 967
Query: 180 NSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRD-L 238
+ K F S ++++ + ++A+ +E ++V E + I L +EL + +D +
Sbjct: 968 DENKLFKS-QIEQLKQQNYQQASSFPPHEELLKVISEREKE----ISGLWNELDSLKDAV 1022
Query: 239 NHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTL 298
H Q++ N +L E+N+ ++A + + KT +E + ++E + L
Sbjct: 1023 EH--QRKKNN--------DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE--L 1070
Query: 299 NARDESIKKLLEMLQ-SKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLR 357
A+ E +KKL + L E+ + A + S +L+ K KE
Sbjct: 1071 EAK-EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKE----A 1125
Query: 358 EELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREE 417
+E+H QL+ E K+ +T + + L+R++ E++ ++ ++ +
Sbjct: 1126 DEMHTLLQLECEKYKSVLAET-----EGILQKLQRSVEQEENKWKV-------KVDESHK 1173
Query: 418 EIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKES 477
IKQ++ + S+ ++ +++ E L+ +LE + S + LK+
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDL 1233
Query: 478 LTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVK 537
LT +++ +E L ++ LN+ +L+ E+ +AG+
Sbjct: 1234 LTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGD----------- 1282
Query: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERII 597
++ Q+ +E +Q ++ T +++ S +T+SS +T +L + +++ ++++
Sbjct: 1283 ---LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLL 1339
Query: 598 ERLKEQ--RERDDRERLE 613
+ + +Q +E++ + LE
Sbjct: 1340 QAVNQQLTKEKEHYQVLE 1357
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 127 bits (320), Expect = 4e-29
Identities = 171/814 (21%), Positives = 344/814 (42%), Gaps = 79/814 (9%)
Query: 144 DSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERV-------L 196
+ +L L+ Q + +E L+ + S+L K K+E + L
Sbjct: 984 EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 197 RKEEAARMSVLKEQMRVSHEEN--QHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHF 254
+KEE R + K + ++ E Q +QA DEL+ Q L ++E +GA
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ-----LAKKEEELQGALAR 1098
Query: 255 TIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 314
+ T L+ + QA+ + E++ E++K + N ++ + L E L++
Sbjct: 1099 GDDETLHKNNALKVVRELQAQ--------IAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 315 KGLPSKSLEDDNERTRRMAEA----ESQVSHLEVILDQKEKENIHLREELHRRSQLQPEP 370
LED + T E E +V+ L+ L+++ K + E + Q
Sbjct: 1151 L---KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH-----EAQIQDMRQRHA 1202
Query: 371 AKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSK 430
+ L +E A+LE+N + LE + + L E+K ++ K+ S+
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC-----------EVKVLQQVKAESE 1251
Query: 431 FMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQT 490
+ K+D QEL K SE L+ +L + + S + ++ + L E++
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVEL---AEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 491 EVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIEN 550
+ +L +L++ + L ++T+Q +L+ L E +++ E +E L+K++
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368
Query: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRE 610
LQ QL D K++ + ++SL+ L + L EK ++L++ + R +E
Sbjct: 1369 LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 611 RLE---EIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSL 667
+ +++ R+ +L++K L E++S E + ++++K SL
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488
Query: 668 EIAIEQKKEECSKLEAQLKKAH-NIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEV 726
A+E+ E + E Q K+ ++ED + + +L+K + + + ++
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1548
Query: 727 DRLLEILKEVENEK-----NDKDKKIAELESLTLRHMKDQNKKVANLKHNQQL------E 775
+ L + L+ E+ K N + K L R +++ KK +K ++L E
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Query: 776 KKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEA 835
+K+ A + ++ E + D QIE A ++ ++L +A++ Q+ L E A
Sbjct: 1609 RKQRALAVASKKKMEIDLKD--LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 836 HLANLRIERRK-------------QLEEILEMKQEALLAAISEKDANIALLELSASKKKK 882
+ + ++ QL+E L + A A E+D + SAS K
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA 1726
Query: 883 TQEEVMALKREKDRLVHQLKQQTQNRMKLMADNY 916
+E L+ +L +L+++ Q+ M+L+ D +
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEE-QSNMELLNDRF 1759
Score = 125 bits (313), Expect = 2e-28
Identities = 152/720 (21%), Positives = 311/720 (43%), Gaps = 87/720 (12%)
Query: 150 LQAQLKELQR---ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSV 206
L AQ++EL E D LR EL K SKL + ++++ T KK K+ A+ S
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
L++ T + LQ+E R + +L+ ++Q + + E EE + L
Sbjct: 1317 LQD--------------TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL 1362
Query: 267 QAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ--SKGLPSKSLED 324
+ K++ L+ L + + +++ T+ + +E+ KKLL+ + S+ L K+L
Sbjct: 1363 E-------KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 325 DN-ERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
D E+T+ + E + L V LD + + +L ++ + QL E
Sbjct: 1416 DKLEKTKNRLQQE--LDDLTVDLDHQRQVASNLEKKQKKFDQLLAE-------------- 1459
Query: 384 DTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQEL 443
+ I++ RD + E RE+E K + + ++ + ++ K +E
Sbjct: 1460 EKSISARYAEERDRAE------------AEAREKETKALSLARALEEALEAK-----EEF 1502
Query: 444 SKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 503
++ +L A +E L + D +++ L++S A EQ+ ++T+++ L L+ E
Sbjct: 1503 ERQNKQLRA---DMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 504 SFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLT 563
+ +Q + + RD++ E E K +L K++ L+ +L D+ KQ
Sbjct: 1560 DAKLRLEVNMQAMKAQFE------RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 564 NLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKE-- 621
K ++ D + + + +A E + + +L+ Q + RE LEE + R E
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE-LEEARASRDEIF 1672
Query: 622 --NKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKK---E 676
+K+ ++K+ +L+AE+ + + L + + A +RD + + K +
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEELASSER---ARRHAEQERDELADEITNSASGKSALLD 1729
Query: 677 ECSKLEAQLKKAHNIEDDSRMNPEFA-DQIKQLDKEASYYRDECGKAQAEVDRLLEILKE 735
E +LEA++ + ++ + N E D+ ++ + E ++ + ++
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ 1789
Query: 736 VENEKNDKDKKIAELESLTLRHMKDQ----NKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
+E + + K+ ELE K K+ L+ + E K+ A + VRR E
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEK 1849
Query: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEI 851
+ + +Q+E+ ++ +++++ AR+ ++ L E E RRK E+
Sbjct: 1850 KLKEI--FMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
Score = 99.8 bits (247), Expect = 1e-20
Identities = 106/546 (19%), Positives = 249/546 (45%), Gaps = 60/546 (10%)
Query: 405 KANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKK------ESELLALQTKLE 458
K +L +EEE++ + K +TK++ +E+ +K E +LA Q + E
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 459 T------------LSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFL 506
T L+ + + ++ + L+ + +E+R ILQ E ++ +++ E L
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 507 NKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLK 566
+++ Q L EK T +I+ M++ + + E + + K+ + +++++ + QL +
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019
Query: 567 DRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLK 626
++ K+L + + ++ LEE L ++E+ + L++ + + D E DL+
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD-----------GETTDLQ 1068
Query: 627 EKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK 686
+++ LQA++ E + L +E + G D + A++ +E +++ A+L+
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARG---DDETLHKNNALKVVRELQAQI-AELQ 1124
Query: 687 KAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKK 746
+ E SR + +K+ +E + E++ L+ + + ++++
Sbjct: 1125 EDFESEKASR---------NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175
Query: 747 IAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEEL- 805
+AEL+ K+ ++ +++ ++ ++ LE+ +R + ++ N Q L+ +
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 806 ----MNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIE-------RRKQLEEILEM 854
+ L++ + E + + +L + Q L K + LR+E + +L+ + +
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 855 KQEALLAAIS-EKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMA 913
+EA I KDA A LE S+ + TQE + R+K L +++Q + + L
Sbjct: 1296 LEEAEKKGIKFAKDA--ASLE---SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 914 DNYDDD 919
+++
Sbjct: 1351 QQEEEE 1356
Score = 80.5 bits (197), Expect = 7e-15
Identities = 136/622 (21%), Positives = 264/622 (42%), Gaps = 96/622 (15%)
Query: 139 LRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKK-ERVLR 197
L+Q D +DL Q Q ++L +K+ K +L + SI ++ E + E R
Sbjct: 1425 LQQELDDLTVDLDHQR---QVASNLEKKQK--KFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 198 KEEAARMSV---LKEQMRVSHE-ENQHLQLTIQALQDELRTQRDLNHLLQQ-ESGNRGAE 252
++E +S+ L+E + E E Q+ QL ++D + ++ D+ + + E R E
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRAD-MEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 253 HFTIELT---EENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 309
E+ EE LQA D + + L ++ M+ + E QT + ++E K+LL
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLR----LEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 310 EMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPE 369
K + E ++ER +R S K+K I L++ +Q++
Sbjct: 1595 ----IKQVRELEAELEDERKQRALAVAS-----------KKKMEIDLKD---LEAQIE-- 1634
Query: 370 PAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHS 429
A KA VI+ ++ L+ ++D + E++ +A+ R+E Q + +
Sbjct: 1635 -AANKARDEVIK----QLRKLQAQMKDYQRELEEARAS-------RDEIFAQSKESEKKL 1682
Query: 430 KFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQ 489
K ++ +I QL++EL+ E + + + L+++ ++ L + E R A L+
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 490 TEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIE 549
E++ + +E K T Q+ L E LA E +K +
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAE---LAAE---------------RSAAQKSD 1784
Query: 550 NLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDR 609
N ++QL ++K+ LK +++ L+ + + +S E I +L+EQ E++ +
Sbjct: 1785 NARQQLERQNKE---LKAKLQELE------GAVKSKFKATISALEAKIGQLEEQLEQEAK 1835
Query: 610 ERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEI 669
ER + R+ K LKE +Q E D + HA K ++++K L+
Sbjct: 1836 ERAAANKLVRRTEKKLKEIF--MQVE---------DERRHADQYKEQMEKANARMKQLKR 1884
Query: 670 AIEQKKEECSKLEAQLKK-AHNIEDDSRMNPEFADQIKQLDKE------ASYYRDECGKA 722
+E+ +EE ++ A +K ++D + N + ++ L S+ G+
Sbjct: 1885 QLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRR 1944
Query: 723 QAEVDRLLEILKEVENEKNDKD 744
Q ++ L + + E D
Sbjct: 1945 QLHLEGASLELSDDDTESKTSD 1966
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 127 bits (319), Expect = 5e-29
Identities = 172/817 (21%), Positives = 349/817 (42%), Gaps = 119/817 (14%)
Query: 150 LQAQLKELQR---ENDLLRKELDIKDSKLGSSMNSIK--------TFWSPELKKERVLRK 198
L+A++KEL E + + EL K L +S+K T E +K K
Sbjct: 919 LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENK 978
Query: 199 EE--AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI 256
+ + M+ L+E + +E + LQ Q D+L+ + D + L + + + +
Sbjct: 979 VKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038
Query: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 316
E + E ++L+A+ +R ++L K +E + +E KQ + + + + L LQ+K
Sbjct: 1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK- 1097
Query: 317 LPSKSLEDDNERT----RRMAEAESQVSHLEVILDQK-------EKENIHLREELHRRSQ 365
++D+ + +++ E ++++ LE ++ + EK+ L EL S+
Sbjct: 1098 -----IDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISE 1152
Query: 366 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425
E + + Q IEM + A ++ RDLE+ +A + + + + ++
Sbjct: 1153 RLEEASGATSAQ--IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210
Query: 426 KSHSKFMKTKIDQLKQELSKKESELLA-----------LQTKLETLSNQNSDCKQHIEVL 474
+ + +K K+++ K EL + ++ + ++ T+ +Q S+ K E
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQ 1270
Query: 475 KESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDML 534
+ + + A LQT+ L R+EEKES +++ TK Q LT++ L R M++
Sbjct: 1271 TQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK---RQMEEET 1327
Query: 535 EVKERKINVLQKKIEN---LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALS 591
+ K + LQ + L+EQ ++ + A A L+ ALS
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQE---------------------AKAELQRALS 1366
Query: 592 EKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHAS 651
+ + + + + E D +R EE+E +K+ L L E E + +
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKK----------LAQRLQEAEENTETANSKCA 1416
Query: 652 SLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE 711
SL + +++ L +E+ C+ L+ KK N DK
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLD---KKQRNF-----------------DKV 1456
Query: 712 ASYYRDECGKAQAEVDRLLEILKEVENE----KNDKDKKIAELESLTLRHMKDQNKKVAN 767
+ ++ + ++QAE++ + + + E +N ++ + +LE+L R K+ +++++
Sbjct: 1457 LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR-RENKNLQEEISD 1515
Query: 768 LKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQ 827
L Q E KN Q E+ ++ + + +L ALE+ L+ ++++ Q
Sbjct: 1516 LTE-QIAETGKNLQEAEKTKKLVEQ--------EKSDLQVALEEVEGSLEHEESKILRVQ 1566
Query: 828 QSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEV 887
L++ ++ L IE+ +++E++ Q A A S DA I + KKK + +
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD- 1625
Query: 888 MALKREKDRLVHQLKQ--QTQNRMKLMADNYDDDHHH 922
L + +L H +Q +TQ ++ + D H
Sbjct: 1626 --LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLH 1660
Score = 119 bits (297), Expect = 2e-26
Identities = 171/804 (21%), Positives = 345/804 (42%), Gaps = 106/804 (13%)
Query: 151 QAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQ 210
Q + +L+ + + ++L K+ +L I L+ ++ + KE AR+ L+E+
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKI-KELQARIEELEEE 1125
Query: 211 MRVSHEENQHLQLTIQALQDEL-RTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAE 269
+ H L+ I+ + +L R +++ L++ SG A+ IE+ ++ +AE
Sbjct: 1126 IEAEHT----LRAKIEKQRSDLARELEEISERLEEASGATSAQ---IEMNKKR----EAE 1174
Query: 270 HDRQAKELFLLRKTLEEMELRIETQKQTLNARD-ESIKKLLEMLQSKGLPSKSLEDDNER 328
+ +R+ LEE L+ E TL + +S+ +L E + + + LE E+
Sbjct: 1175 FQK-------MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLE--KEK 1225
Query: 329 TRRMAEAESQVSHLEVILDQKEKENIH------------LREELHRRSQLQPEPAKTKA- 375
+ E + S++E + K K NI ++ + +++QL + KA
Sbjct: 1226 SELKMEIDDMASNIEAL--SKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKAR 1283
Query: 376 LQTV-------IEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSH 428
LQT +E K++ I+ L ++ + L +++ LK T+ + ++ +
Sbjct: 1284 LQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHD 1343
Query: 429 SKFMKTKIDQ-------LKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAK 481
++ + ++ L++ LSK SE+ +TK ET D Q E L+E AK
Sbjct: 1344 CDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYET------DAIQRTEELEE---AK 1394
Query: 482 EQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKI 541
++ A RL+E E + L + K L GE+ D+ LE
Sbjct: 1395 KKLAQ-----------RLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTAC 1443
Query: 542 NVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLK 601
L KK N + L + ++L + +++ Q +S + T L + A E +E L+
Sbjct: 1444 ATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR 1503
Query: 602 EQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRD 661
+ + E + E + K+L+E + EK + L+E SL +
Sbjct: 1504 RENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE----HEE 1559
Query: 662 SKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQ-LDKEASYYRDECG 720
SK+ +++ + Q K E + ++K IE R + A+ ++ LD E D
Sbjct: 1560 SKILRVQLELSQVKSELDR--KVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR 1617
Query: 721 -KAQAEVDRLLEILKEVENEKNDKDKKIAELESL----------TLRHMKDQNKKVANLK 769
K + E D L E+E + ++++AE + + H+ D + +LK
Sbjct: 1618 LKKKMEGD-----LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK 1672
Query: 770 HNQQLEKKKNAQLLEEVRRREDSM--ADNSQHLQIEELMNALEKTRQELDATKARLASTQ 827
+ +++N LLEE+ + ++ + ++ L +EL++A ++ Q L + L +T+
Sbjct: 1673 EQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV-QLLHSQNTSLINTK 1731
Query: 828 QSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEV 887
+ L EA +A + E ++E +++A A + A++ K++ T +
Sbjct: 1732 KKL---EADIAQCQAEVENSIQESRNAEEKAKKAI-----TDAAMMAEELKKEQDTSAHL 1783
Query: 888 MALKREKDRLVHQLKQQTQNRMKL 911
+K+ ++ V L+ + +L
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQL 1807
Score = 115 bits (288), Expect = 2e-25
Identities = 150/664 (22%), Positives = 287/664 (43%), Gaps = 70/664 (10%)
Query: 124 LTGSSHHHHHQVPSMLRQVRDSTMLD--LQAQLKELQRENDLLRKELDIKDSKLG----- 176
LT S Q+ + RQ+ + T + L+ + + DLLR++ + +
Sbjct: 1305 LTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 177 -SSMNSIKTFWSPELKKERVLRKEE--------AARMSVLKEQMRVSHEENQHLQLTIQA 227
S NS W + + + + R EE A R+ +E ++ + L+ T Q
Sbjct: 1365 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQR 1424
Query: 228 LQDELRT-QRDLNHL--------LQQESGNRGAEHFTIELTEEN--FRRLQAEHDRQAKE 276
LQ E+ RDL +Q + ++ + +L E Q E + E
Sbjct: 1425 LQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTE 1484
Query: 277 LFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAE 336
LF +R EE+ ++ET ++ E I L E + G K+L++ E+T+++ E E
Sbjct: 1485 LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG---KNLQEA-EKTKKLVEQE 1540
Query: 337 SQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRD 396
S L+V L++ E H ++ R QL+ K++ + VIE KD +I L+RN +
Sbjct: 1541 K--SDLQVALEEVEGSLEHEESKI-LRVQLELSQVKSELDRKVIE-KDEEIEQLKRNSQR 1596
Query: 397 LEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTK 456
+ +Q VL+ E R + + K M+ +++++ +L ++ Q
Sbjct: 1597 AAEALQ-----SVLDAEIRSRN----DALRLKKK-MEGDLNEMEIQLGHSNRQMAETQKH 1646
Query: 457 LETLSNQNSDCKQHI-------EVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKK 509
L T+ Q D + H+ E LKE L E+R +L E++ +++ LE+ E
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706
Query: 510 TKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRV 569
++L D ++ L + + + + E I Q ++EN ++ R N +++
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR-------NAEEKA 1759
Query: 570 KSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKV 629
K TD++ L ++ + ER+ + L EQ +D + RL+E E K K+++
Sbjct: 1760 KKAITDAAMMAEELKKEQDTSAHLERMKKNL-EQTVKDLQHRLDEAEQLAL--KGGKKQI 1816
Query: 630 NALQAELTEKESSL-IDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKA 688
L+ + E E+ L ++ K A +L A K + K+K + E+ + +L+ + K
Sbjct: 1817 QKLENRVRELENELDVEQKRGAEALKGAH-KYERKVKEMTYQAEEDHKNILRLQDLVDKL 1875
Query: 689 HNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIA 748
+ Q ++ +++A+ C + Q E++ E E++ N K
Sbjct: 1876 ------QAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSR 1929
Query: 749 ELES 752
++ S
Sbjct: 1930 DVGS 1933
Score = 113 bits (283), Expect = 7e-25
Identities = 112/517 (21%), Positives = 237/517 (45%), Gaps = 47/517 (9%)
Query: 432 MKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAA----- 486
MK ++ K+EL++ E+ L+ K+ +L + +D + ++ E+L E+R
Sbjct: 856 MKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKS 915
Query: 487 --ILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVL 544
+L+ +V L RLEE+E ++ + ++L ++ +L +I D++ L E++ +
Sbjct: 916 KILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHAT 975
Query: 545 QKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQR 604
+ K++NL E++ ++ ++ L KSLQ T L E+ ++ +I +L++Q
Sbjct: 976 ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQ- 1034
Query: 605 ERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKL 664
DD E +E +K DL+ L+ +L + S++DL+ + K++ +L
Sbjct: 1035 -TDDLE--GSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFEL 1091
Query: 665 KSLEIAIE---------QKK-----EECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDK 710
L+ I+ QKK +LE +++ H + +++ + +D ++L++
Sbjct: 1092 SQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR--AKIEKQRSDLARELEE 1149
Query: 711 EASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKH 770
+ + G A+++ + E + + D ++ + E+ K Q VA L
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGE 1209
Query: 771 ---NQQLEKKKNAQLLEEVRRREDSMADNSQHL-----QIEELMNALEKTRQELDATKAR 822
N Q K+K + E++ D MA N + L IE +E E+ A +
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Query: 823 LASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKK 882
L ++A L E ++EE +E+L++ +++ + AL + K++
Sbjct: 1270 QTQLIHDLNMQKARLQTQNGELSHRVEE-----KESLISQLTK--SKQALTQQLEELKRQ 1322
Query: 883 TQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDD 919
+EE A K+ + H L Q +++ L+ + Y+++
Sbjct: 1323 MEEETKA----KNAMAHAL-QSSRHDCDLLREQYEEE 1354
Score = 107 bits (268), Expect = 4e-23
Identities = 157/780 (20%), Positives = 334/780 (42%), Gaps = 97/780 (12%)
Query: 149 DLQAQLKELQRENDL---LRKELDIKDSKLGSSMNSIK---------TFWSPELKKER-- 194
+LQA+++EL+ E + LR +++ + S L + I T E+ K+R
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173
Query: 195 ---------------------VLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELR 233
LRK++A ++ L EQ+ Q L+ L+ E+
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
Query: 234 TQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIET 293
D+ ++ S ++ T E+ F ++A+ ++Q + L L + R++T
Sbjct: 1234 ---DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ----LIHDLNMQKARLQT 1286
Query: 294 QKQTLNARDESIKKLLEML-QSKGLPSKSLEDDNERTRRMAEAESQVSHL--------EV 344
Q L+ R E + L+ L +SK ++ LE+ + +A++ ++H ++
Sbjct: 1287 QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL 1346
Query: 345 ILDQKEKENIHLREELHRRSQLQPEPAK------TKALQTVIEMKDTKIASLERNIRDLE 398
+ +Q E+E E S+ E A+ T A+Q E+++ K L + +++ E
Sbjct: 1347 LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK-KKLAQRLQEAE 1405
Query: 399 DEIQML--KANGVLNTEDR-----EEEIKQIE--------VYKSHSKFMKTKIDQLKQEL 443
+ + K + T+ R E+ ++ +E + K F K + + KQ+L
Sbjct: 1406 ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKV-LAEWKQKL 1464
Query: 444 SKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 503
+ ++EL A Q + +LS + + E + + L + LQ E+ L ++ E
Sbjct: 1465 DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524
Query: 504 SFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLT 563
L + K + + +EK L + +++ LE +E KI +Q ++ ++ +L D+++
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSEL---DRKVI 1581
Query: 564 NLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENK 623
+ ++ L+ +S AL ++ +A RLK++ E D E ++ ++
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMA 1641
Query: 624 DLKEKVNALQAELTEKESSLID-------LKEHASSLASAGLKRDSKLKSLEIAIEQKKE 676
+ ++ + +Q +L + + L D LKE + + +L+ +++A+EQ +
Sbjct: 1642 ETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTER 1701
Query: 677 ECSKLEAQLKKAHN-IEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKE 735
E +L A + ++ N + K+L+ + + + QAEV+ ++ +
Sbjct: 1702 TRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIA-------QCQAEVENSIQESRN 1754
Query: 736 VENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMAD 795
E EK K A + + L+ +D + + +K N + K L+E + +A
Sbjct: 1755 AE-EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA----EQLAL 1809
Query: 796 NSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMK 855
QI++L N + + ELD + R A + + E + + + + + IL ++
Sbjct: 1810 KGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQ 1869
Score = 44.3 bits (103), Expect = 6e-04
Identities = 65/342 (19%), Positives = 140/342 (40%), Gaps = 39/342 (11%)
Query: 126 GSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTF 185
G S+ + LR V+ + D Q L + R N+ L+++L I + + G + ++
Sbjct: 1634 GHSNRQMAETQKHLRTVQGQ-LKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692
Query: 186 WSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDEL-RTQRDLNHLLQQ 244
+ ER R E + +++++ H +N L T + L+ ++ + Q ++ + +Q
Sbjct: 1693 KVALEQTERTRRLSEQELLDA-SDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQ- 1750
Query: 245 ESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDES 304
ES N EE ++ + A+EL K ++ +E K+ L +
Sbjct: 1751 ESRN----------AEEKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKNLEQTVKD 1796
Query: 305 IKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRS 364
++ L+ + L +++ + E++V LE LD ++K + H+
Sbjct: 1797 LQHRLDEAEQLALKGGK--------KQIQKLENRVRELENELDVEQKRGAEALKGAHKYE 1848
Query: 365 QLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEV 424
+ K K + E +NI L+D + L+A EE +Q
Sbjct: 1849 R------KVKEMTYQAEED-------HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895
Query: 425 YKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSD 466
S + ++ ++++ + ES++ L+ K + +Q +
Sbjct: 1896 QLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 34.3 bits (77), Expect = 0.57
Identities = 32/157 (20%), Positives = 71/157 (45%), Gaps = 17/157 (10%)
Query: 764 KVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARL 823
K+ L + + EK+ + R +E+ ++ ++EE M +L + + +L
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 824 ASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKT 883
E+ L +I +++E+ E +E E++ N L+ +KK+
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEE-------EEEMNSELV----AKKRNL 947
Query: 884 QEEVMALKREKDRL------VHQLKQQTQNRMKLMAD 914
+++ +LKR+ D L V + K T+N++K +++
Sbjct: 948 EDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSE 984
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 127 bits (319), Expect = 5e-29
Identities = 186/832 (22%), Positives = 356/832 (42%), Gaps = 130/832 (15%)
Query: 149 DLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSP-ELKKERVLRKEEAA----- 202
+LQ ++KE EN L ++ +D K+ S +N +K S L++ +++ K EA
Sbjct: 1771 NLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEK 1830
Query: 203 RMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEEN 262
+ LK++ E+ ++ Q L + T LN L+ + E + + N
Sbjct: 1831 IVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVN 1890
Query: 263 FRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSL 322
KE FL +E RI ++K ++ ++ LE++Q++ L L
Sbjct: 1891 ---------DSWKERFL---DVENELSRIRSEKASIEHEALYLEADLEVVQTEKL---CL 1935
Query: 323 EDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEM 382
E DNE ++ VI+ +E+ ++ E R +L KT AL + E
Sbjct: 1936 EKDNENKQK------------VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEK 1983
Query: 383 KDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQE 442
K LE + + IQ+ +A E+K+ KT +L Q
Sbjct: 1984 MKEKTQELESHQSECLHCIQVAEA-----------EVKE-----------KT---ELLQT 2018
Query: 443 LSKKESELLA----LQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLR 498
LS SELL LQ KL++L + L+ + + +L E ++L+ R
Sbjct: 2019 LSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQAR 2078
Query: 499 LEEKESFLNKKTKQLQDLTEEKGTLA-------GEIRDMKDMLEVKERKINVLQKKIENL 551
L E + +K L+ EKG A E+ ++ +E +I +KK ++
Sbjct: 2079 LSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHI 2138
Query: 552 QEQLRDKDKQLTNLKDRV----KSLQTDSSNTDTALATLEEALSEKERIIERLKEQRE-- 605
E+L++++++ +LKD+V + LQ N + + E + +E E + +++E
Sbjct: 2139 AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSL 2198
Query: 606 ----------RDDRERL-EEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLA 654
R ++E L ++I+ + + +L + +++ ++ L EKE + I +KE + +
Sbjct: 2199 KVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAV 2258
Query: 655 SAGLKRDSKLKSLEIAI-------EQKKEECSKLEAQLKKAHNIEDD-SRMNPEF-ADQI 705
++LK L A+ E K L+ +++ H + + ++ AD+
Sbjct: 2259 E---MLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
Query: 706 KQLD-----KEASYYRDECGKAQAEVDRLLEILK--------EVENEKNDKDKKIAELES 752
KQL KE+ ++ D ++R LEI + E EN K + + A++E
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEG 2375
Query: 753 LT--LRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEEL----- 805
+T LR ++ + + K N E +K + + E+ S + Q + E++
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435
Query: 806 ----MNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLA 861
M L+ +EL+ A L + Q++ KE +L++ E LE+++ LL
Sbjct: 2436 SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS--------QVECLELEKAQLLQ 2487
Query: 862 AISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMA 913
+ E N +L+ S + + E+ +KD + +LK Q Q++ +L++
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
Score = 119 bits (298), Expect = 1e-26
Identities = 192/911 (21%), Positives = 370/911 (40%), Gaps = 177/911 (19%)
Query: 148 LDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSP--ELKKERVLRKEEAARMS 205
L L+A L+ +Q E L K+ + K + + S +L+ E ++ +
Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD 1978
Query: 206 VLKEQMRVSHEE-NQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFR 264
L E+M+ +E H + +Q ++ LLQ S + + T +
Sbjct: 1979 QLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD--VSELLKDKTHLQEK 2036
Query: 265 RLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIK-KLLEMLQSKGLPSKSLE 323
E D QA L L + LE ++ +K+ L ES++ +L E K SK+LE
Sbjct: 2037 LQSLEKDSQA--LSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094
Query: 324 ----DDNERTRRMAEAESQVSHLE-------VILDQKEKENIHLREELHRRSQLQPEPAK 372
+ E R++ + +V L V ++ EK+ +H+ E+L R +
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND---- 2150
Query: 373 TKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFM 432
SL+ + +LE E+QM + N L D E ++E +
Sbjct: 2151 ----------------SLKDKVENLERELQMSEENQELVILDAENSKAEVET-------L 2187
Query: 433 KTKIDQLKQELSKKESELLALQTKLETLSNQNSDC----------------------KQH 470
KT+I+++ + L E +L+ L+++ E L+ Q + +
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAE 2247
Query: 471 IEVLKESLTA--------KEQRAAI--------------------------LQTEVDALR 496
I++ +ES TA KE A+ L+ ++ LR
Sbjct: 2248 IQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLR 2307
Query: 497 LRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEV--------------KERKIN 542
RLE E +QL++ L G + +++ LE+ + ++
Sbjct: 2308 ARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVE 2367
Query: 543 VLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKE 602
L+ KIE + + LR + + ++ ++L + ++ LE S E I++ ++
Sbjct: 2368 TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ 2427
Query: 603 QRERDDRERLEEIESFRKENKDLKEKVNAL----------------QAELTEKESS---- 642
++ + + +E + + K+L E+V AL Q E E E +
Sbjct: 2428 EKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQ 2487
Query: 643 -LIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK-------KAHNIEDD 694
L + K + L S+ +++ + +E+K EE S+L+ Q++ K +E +
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE 2547
Query: 695 SRM----NPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENE----KNDKDKK 746
++ N E + +L+++ + + Q ++ L K +ENE K DK
Sbjct: 2548 HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSF 2607
Query: 747 IAELESLTL------RHMKDQNKKVANLKHNQQLEKKKNA----QLLEEVRRREDSMAD- 795
+ ++ +T R M + +K A L+ EK + A LLEE++ +D + +
Sbjct: 2608 VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKEL 2667
Query: 796 NSQHLQIEELMNALEKTRQELDA-TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEM 854
++ ++++ ++ + K + E + + +A Q L E E L ++ KQ E ++
Sbjct: 2668 TLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQT 2727
Query: 855 KQEALLA---AISEKDANIALL-----ELSASKKKKTQ--EEVMALKREKDRLVHQLK-- 902
+E L + +S + I LL EL+ S K TQ EE+ K + + V+QLK
Sbjct: 2728 YREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKE 2787
Query: 903 -QQTQNRMKLM 912
++ Q +MKL+
Sbjct: 2788 NERAQGKMKLL 2798
Score = 115 bits (288), Expect = 2e-25
Identities = 151/745 (20%), Positives = 314/745 (42%), Gaps = 122/745 (16%)
Query: 151 QAQLKELQRENDLLRKELDIKD---SKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVL 207
+ L L+ E + L K++ K S+L ++S K+ + + E +++E + +L
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261
Query: 208 KEQMRVSHE-------ENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFT----- 255
+ Q++ +E + + ++ T Q+L + + L + +++ A+
Sbjct: 2262 QNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVL 2321
Query: 256 --IELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ 313
++ +E + L+ + +EL + R E L E K + I+ + + L+
Sbjct: 2322 QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLR 2381
Query: 314 SKGLPSKSLEDDNER-TRRMAEAESQVSHLEVI-------LDQKEKENIHLREELHRRSQ 365
L ++ + E T + + + ++S LE+I L +KE+E + ++E+
Sbjct: 2382 GLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKS----- 2436
Query: 366 LQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVY 425
T +EM T++ L + L ++ + KA ++ +++ +E+
Sbjct: 2437 -----------STAMEMLQTQLKELNERVAALHNDQEACKAK----EQNLSSQVECLELE 2481
Query: 426 KSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRA 485
K+ QL Q L + ++ + LQ+ + L + D KQ +E E
Sbjct: 2482 KA----------QLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDE--------- 2522
Query: 486 AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQ 545
E+ L+ +++++E ++K L + E + +++++ E+KI VLQ
Sbjct: 2523 -----EISRLKNQIQDQEQLVSK----LSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 546 KKIENLQEQLRDKDKQLTNLKDRVK---------------------SLQTDSSNTDTALA 584
K +LQ+ L NL++ ++ LQ + A
Sbjct: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2633
Query: 585 TLEEALS-EKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 643
L+E LS EK R+ L+ E + + ++++ EN +LK+ ++ + + EKE +
Sbjct: 2634 ELQEELSGEKNRLAGELQLLLE-EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKV 2692
Query: 644 -IDLKEHASSLASAGLKRDSKL----KSLEIAIE------QKKEEC---SKLEAQLKKA- 688
++ E+ L A K + L K E+ I+ KEEC KLE L K+
Sbjct: 2693 REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS 2752
Query: 689 -HNIEDDSRMNPEFADQIKQLD----KEASYYRDECGKAQAEVDRLLEILKEVENEKNDK 743
+ + + + +++K+ K + + E +AQ ++ L++ K++E EK
Sbjct: 2753 KEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEIL 2812
Query: 744 DKKIAELESLTLRHMKDQNKKVANLKHNQ-QLEKKKNAQLLEEVRRREDSMADNSQHLQI 802
K++++L++ K + V + K ++ E K+ + LEE + D D L I
Sbjct: 2813 QKELSQLQA---AQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLI 2869
Query: 803 EELMNALEKTRQELDATKARLASTQ 827
LEK ++ L+ A L S Q
Sbjct: 2870 SH--EKLEKAKEMLETQVAHLCSQQ 2892
Score = 111 bits (278), Expect = 3e-24
Identities = 161/784 (20%), Positives = 343/784 (43%), Gaps = 91/784 (11%)
Query: 149 DLQAQLKELQRENDLLRKELDIKDSK---LGSSMNSIKTFWSPELKKERVLRKEEAARMS 205
+L+ ++E+++EN+LL+ + K + L + + +IK + ++ + ++ +
Sbjct: 476 ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQET 535
Query: 206 VLKE-QMRVSHEENQHLQLTIQALQDELRTQRDLNH-LLQQESGNRGAEHFTIELTEENF 263
+L++ Q +++ +EN ++ +L QRD + LL++ + + + TE+
Sbjct: 536 MLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKES 595
Query: 264 RRLQAEHDRQAKELFLLR--KTL--------EEMELRIETQKQTLNARDESIKKLLEMLQ 313
+ L + + + KE L+ KTL E++ ++E++K+ L ++ ++ L+ Q
Sbjct: 596 KALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQ 655
Query: 314 SKGLPSKSLEDDNERTRRMAEAESQVS----HLEVILDQKEKENIHLREELHRRSQLQPE 369
K + NER R + +S +L +LD K E + ++ + Q + E
Sbjct: 656 IKS------HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVE-VETQKLAYMELQQKAE 708
Query: 370 PAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTE----DREEEIKQI-EV 424
+ K Q IE K + L + DLE ++Q+L +N +++ + D E + + ++
Sbjct: 709 FSDQKH-QKEIENMCLKTSQLTGQVEDLEHKLQLL-SNEIMDKDRCYQDLHAEYESLRDL 766
Query: 425 YKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQR 484
KS + T D + L+ + + + + Q S + E E+ +
Sbjct: 767 LKSKDASLVTNEDHQRSLLAFDQQPAMH-HSFANIIGEQGSMPSERSECRLEA-DQSPKN 824
Query: 485 AAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDM----------- 533
+AILQ VD+L LE ++ + KQ ++L + KG + + + M
Sbjct: 825 SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884
Query: 534 ---------------------LEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSL 572
LE KE+++ +L K+E Q ++++ K L+D +K L
Sbjct: 885 ISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL 944
Query: 573 QTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIE-SFRKENKDLKEKVNA 631
Q S + +S +R IE L + + L+EI S +E +L +K +
Sbjct: 945 QLLSETLSLEKKEMSSIISLNKREIEELTQ-----ENGTLKEINASLNQEKMNLIQKSES 999
Query: 632 LQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQK----KEECSKLEAQLKK 687
+ E+E S+ +L + L+R + + + QK +E+ SKLE L +
Sbjct: 1000 FANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNE 1059
Query: 688 AHNIEDD-----SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKE--VENEK 740
++ ++ ++ FA + ++ + ++ + E++ + + L+ +N+
Sbjct: 1060 CTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQN 1119
Query: 741 NDKDKKIA-ELESLTLRHMKDQNKKVAN--LKHNQQLEKKKNAQLLEEVRRREDSMADNS 797
N K + + E +TL+ +++ +K N L+ N+QL K + E + E NS
Sbjct: 1120 NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK--HECQNLESEPIRNS 1177
Query: 798 QHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLAN--LRIERRKQLEEILEMK 855
+ E K + +L+ + L S L + EA L N L+++ ++ +E L+ +
Sbjct: 1178 VKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHE 1237
Query: 856 QEAL 859
+ +
Sbjct: 1238 LQTI 1241
Score = 108 bits (270), Expect = 2e-23
Identities = 156/817 (19%), Positives = 332/817 (40%), Gaps = 55/817 (6%)
Query: 131 HHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPEL 190
H QV ++ + + Q+++L++E + EL+ S+ S+ +P+
Sbjct: 88 HELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQK 147
Query: 191 KKERVLRKEE---AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQ---------RDL 238
L + ++ LKE+ EE + L+ ++ALQ + +Q RD+
Sbjct: 148 IFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDI 207
Query: 239 NHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTL 298
S + T N +R D A F + + ++ K+
Sbjct: 208 ARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSA-SYFSGEQEVTPSRSTLQIGKRDA 266
Query: 299 NAR---DESIKKLLEML--QSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKEN 353
N+ + S LL+ L Q++ L +K E + E + QV+ + + Q EK
Sbjct: 267 NSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAK 326
Query: 354 IHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTE 413
+ L E+ ++ + E +T A + TK +LE+ ++ L +++ + N
Sbjct: 327 VELIEKEKVLNKCRDELVRTTA---QYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC 383
Query: 414 DREEEIK------QIEVYKSHSKFMKTKID------QLKQELSKKESELLALQTKLETLS 461
E++IK Q E+ + F + +L QEL + ++ LQ +L+ L+
Sbjct: 384 SLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLT 443
Query: 462 NQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKG 521
+ + ++E K+ L EQ Q + + LR +EE + N + E
Sbjct: 444 SVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC 503
Query: 522 TLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKD--RVKSLQTDSSNT 579
L E++++K L + ++ K + + LRD +++ ++ ++ L+ ++
Sbjct: 504 HLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADL 563
Query: 580 DTALATLEEALSEKERIIERLKE---QRERDDRERLEEIESFRKENKDLKEKVNALQAEL 636
+ ++ L ++E IE+L + + E++ + L +E +KE ++LKE+
Sbjct: 564 EKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWK 623
Query: 637 TEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLE-------AQLKKAH 689
+E E L ++ +L S ++ LK+ +I + E LE +++ H
Sbjct: 624 SENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH 683
Query: 690 NIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAE 749
N+ D + E ++ + + D+ K Q E++ + ++ + D + K+
Sbjct: 684 NVLDSKSVEVETQKLAYMELQQKAEFSDQ--KHQKEIENMCLKTSQLTGQVEDLEHKLQL 741
Query: 750 LESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNAL 809
L + + + A + + L K K+A L+ + +A + Q N +
Sbjct: 742 LSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANII 801
Query: 810 -EKTRQELDATKARLASTQ----QSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAIS 864
E+ + ++ RL + Q ++ + +E +KQ+ L+ + E L+
Sbjct: 802 GEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG 861
Query: 865 EKDANIALLE-LSASKKKKTQEEVMALKREKDRLVHQ 900
E + N+ E + S +T + + K ++D HQ
Sbjct: 862 EIEENLMKAEQMHQSFVAETSQRIS--KLQEDTSAHQ 896
Score = 107 bits (267), Expect = 5e-23
Identities = 143/678 (21%), Positives = 302/678 (44%), Gaps = 79/678 (11%)
Query: 281 RKTLEEMELRI-ETQKQTLNA------RDESIKKLLEMLQSKGLPSKSLEDDNERTRRMA 333
++ + ++LR+ ET + L RD ++ LL + K L SK + + M
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLN--EMKELDSKL---HLQEVQLMT 1820
Query: 334 EAESQVSHLEVILDQKEKENIHLREELHRRS----QLQPEPAKTKALQTVIEMKDTKIAS 389
+ E+ + LE I+ + +KEN L E+L S +L ++ L + +EM K +
Sbjct: 1821 KIEACIE-LEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSR 1879
Query: 390 LERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESE 449
D+ D + + + D E E+ +I K+ ++ E E++
Sbjct: 1880 -----EDIGDNVAKVNDSWKERFLDVENELSRIRSEKA----------SIEHEALYLEAD 1924
Query: 450 LLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKK 509
L +QT+ L N + ++ I L+E L+ L+ E+D + +K + L++
Sbjct: 1925 LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDT----MSKKTTALDQL 1980
Query: 510 TKQLQDLTEEKGTLAGEIRDMKDMLEVK-ERKINVLQKKIENLQEQLRDKDKQLTNLKDR 568
++++++ T+E + E + E + + K +LQ ++ E L+DK T+L+++
Sbjct: 1981 SEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK----THLQEK 2036
Query: 569 VKSLQTDSSNTDTALATLEEALS----EKERII---ERLKEQRERDDRERL---EEIESF 618
++SL+ DS LE ++ EKE ++ E L+ + D E+L + +E+
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096
Query: 619 RKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEEC 678
E + ++++ Q E+ + + L+ + L KLK E + K++
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2156
Query: 679 SKLEAQLKKAHNIEDDSRMNPE--------FADQIKQLDKEASYYRDECGKAQAEVDRLL 730
LE +L+ + ++ ++ E QI+++ + + + ++E + L
Sbjct: 2157 ENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT 2216
Query: 731 EILKEVENEKNDKDKKIAELESLTLR------HMKDQNKKVANLKHNQQLEKKKNAQLL- 783
+ ++E + + ++ DK ++ +SL +K+++K + NQ E + L
Sbjct: 2217 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALC 2276
Query: 784 --EEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAH--LAN 839
+E+ + + D + +L N++EK R L+A + + Q L E E H L
Sbjct: 2277 GDQEIMKATEQSLDPPIE-EEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLK 2335
Query: 840 LRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQE------EVMALKRE 893
R+E ++ EI QE AA+ +++ + L A + TQ +V+ ++ E
Sbjct: 2336 GRVENLERELEIARTNQEH--AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2393
Query: 894 KDRLVHQLKQQTQNRMKL 911
K+ L ++L+++ + +L
Sbjct: 2394 KENLTNELQKEQERISEL 2411
Score = 102 bits (253), Expect = 2e-21
Identities = 161/738 (21%), Positives = 299/738 (40%), Gaps = 117/738 (15%)
Query: 240 HLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLN 299
HLL Q I E + + E Q + L+ LE+ ++ + +++ LN
Sbjct: 278 HLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLN 337
Query: 300 -ARDESIKKLLEMLQSK----GLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENI 354
RDE ++ + Q+ L K + + + + AES LE + +KEKE
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE-- 395
Query: 355 HLREELHR---------------RSQLQPEPAKTKALQTVIEMKDTKIAS----LERNIR 395
+EEL R +++L E + K + V++ + K+ S LE N+
Sbjct: 396 -FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLE 454
Query: 396 DLEDEI----QMLKANGVLNTEDR---EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKES 448
+ + ++ Q +A+ + E R EE K+ + KSHS+ ++ L+ EL +
Sbjct: 455 EFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQ 514
Query: 449 ELLALQTKLETLSNQNS-------DCKQHIEVLKESLTAKEQRAAILQTE---------- 491
L Q E + +N+ D ++ I + SLT ++ + A+ E
Sbjct: 515 CLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLL 574
Query: 492 ------VDALRLRLEEKE-------SFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKE 538
++ L +L + E S L K K+ ++L EEK + + + +L E
Sbjct: 575 KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME 634
Query: 539 RKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIE 598
+ LQ KI +L+ L+ + + +RV++L+ D N + L L K +E
Sbjct: 635 SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVE 694
Query: 599 -------RLKEQRERDDRERLEEIESFRKEN-------KDLKEKVNALQAELTEKESSLI 644
L+++ E D++ +EIE+ + +DL+ K+ L E+ +K+
Sbjct: 695 TQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQ 754
Query: 645 DLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQ 704
DL SL LKS + ++ ++ L A + M+ FA+
Sbjct: 755 DLHAEYESLRDL-------LKSKDASLVTNEDHQRSLLA-------FDQQPAMHHSFANI 800
Query: 705 IKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKK 764
I + S R EC +E +++ K+ I + +L + K+
Sbjct: 801 IGEQGSMPSE-RSEC---------------RLEADQSPKNSAILQNRVDSLEFSLESQKQ 844
Query: 765 VANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ-IEELMNALEKTRQELDATKARL 823
+ N L+K+ + + E+ M H + E + K +++ A + +
Sbjct: 845 M-----NSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVV 899
Query: 824 ASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKT 883
A T +L KE L L + + EI E+K+ L S K+ + LL + S +KK
Sbjct: 900 AETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE--LQLLSETLSLEKKE 957
Query: 884 QEEVMAL-KREKDRLVHQ 900
+++L KRE + L +
Sbjct: 958 MSSIISLNKREIEELTQE 975
Score = 87.0 bits (214), Expect = 7e-17
Identities = 116/516 (22%), Positives = 241/516 (46%), Gaps = 63/516 (12%)
Query: 139 LRQVRDSTMLDLQAQLKELQRENDLLRKELDI---KDSKLGSSMNSIKTFWSPELKKERV 195
+++ + M LQ QLKEL L + + K+ L S + + EL+K ++
Sbjct: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL------ELEKAQL 2485
Query: 196 LRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQD-ELRTQRDLNHLLQQESGNRGAEHF 254
L+ + A+ + + Q V+ IQ ++D + + ++ + + ++ + E
Sbjct: 2486 LQGLDEAKNNYIVLQSSVNG--------LIQEVEDGKQKLEKKDEEISRLKNQIQDQEQL 2537
Query: 255 TIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 314
+L++ ++ EH ++ LR E+E +I Q L +++ S++ LE+LQS
Sbjct: 2538 VSKLSQ-----VEGEHQLWKEQNLELRNLTVELEQKI----QVLQSKNASLQDTLEVLQS 2588
Query: 315 KGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTK 374
K+LE++ E T+ ++S +E + KE L+ E+H +Q KT
Sbjct: 2589 S---YKNLENELELTKM-----DKMSFVEKVNKMTAKET-ELQREMHEMAQ------KTA 2633
Query: 375 ALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEI--KQIEVYKSHSKFM 432
LQ + + ++A E+Q+L + +++D+ +E+ + E+ KS
Sbjct: 2634 ELQEELSGEKNRLAG----------ELQLLLEE-IKSSKDQLKELTLENSELKKSLDCMH 2682
Query: 433 KTKIDQ---LKQELSKKESELLALQTKLETLS-NQNSDCKQHIEVLKESLTAKEQRAAIL 488
K ++++ +++E+++ + L + K + L + N + I+ +E LT+KE+ +
Sbjct: 2683 KDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQ 2742
Query: 489 QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKI 548
+ E+D L+ EE + L T+ L++L + K + +K E + K+ +L K
Sbjct: 2743 KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSC 2802
Query: 549 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSE-KERIIERLKEQRERD 607
+ L+E+ K+L+ L+ + Q + DT + L + E KE + E+ KE E
Sbjct: 2803 KQLEEEKEILQKELSQLQ-AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYL 2861
Query: 608 DR--ERLEEIESFRKENKDLKEKVNALQAELTEKES 641
D+ L E K + L+ +V L ++ ++++S
Sbjct: 2862 DKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDS 2897
Score = 83.6 bits (205), Expect = 8e-16
Identities = 164/825 (19%), Positives = 325/825 (39%), Gaps = 160/825 (19%)
Query: 149 DLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLK 208
DLQ Q +EL + ++ E++ K S S + K L+++ +A +V+
Sbjct: 848 DLQKQCEELVQ----IKGEIEENLMKAEQMHQSFVAETSQRISK---LQEDTSAHQNVVA 900
Query: 209 EQMRVSHEENQHLQLT---IQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRR 265
E + + + LQL ++ Q E++ + NHLL+ T+ L ++
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 266 LQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD 325
+ + + R+ +EL TL+E+ + +K L + ES ++
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID--------------- 1005
Query: 326 NERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVI----- 380
ER + ++E Q ++IL Q+ +E + E+L ++ + E K L+ ++
Sbjct: 1006 -EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE--KNSKLECLLNECTS 1062
Query: 381 ----------EMKD----------TKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIK 420
++K+ TK+A E ++L E++ ++ L +E + +
Sbjct: 1063 LCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQ--ALRSEMTDNQNN 1120
Query: 421 QIEVYKSHSKFMKTKIDQLKQELSKKESE---LLALQTKLETLSNQNSDCKQ-HIEVLKE 476
KS + +K +I LK+E +K + E LL +L + +C+ E ++
Sbjct: 1121 S----KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRN 1176
Query: 477 SLTAKEQRA-----------AILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAG 525
S+ +E + + +D+ +L + E+ L K +LQ+ +EK L
Sbjct: 1177 SVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQH 1236
Query: 526 EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALAT 585
E++ ++ LE + ++ ++I L++ D +++ + + + Q D+++ +L T
Sbjct: 1237 ELQTIRGDLETSNLQ-DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQT 1295
Query: 586 LEEALSEKERIIERLKEQR-----ERDD---------RERLEEIESFRKENKDLKEKVNA 631
L+E E+I E L+ ++ E +D R+ EE+ E K L +
Sbjct: 1296 TMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGL 1355
Query: 632 LQAELTE--------------KESSLIDLKE----------------HASSLASAGLKRD 661
L EL E SL L E H + L L
Sbjct: 1356 LHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQ 1415
Query: 662 SKLKSLEIAIEQKKEECSKLEAQLK--KAHNIEDDSRMNPEFADQIKQLD---------- 709
S+ K L Q + S+L+ + KA N+ + + D +K++
Sbjct: 1416 SEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPS 1475
Query: 710 ---------------KEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAEL--ES 752
++S+YR A E + +L +E + + E+ S
Sbjct: 1476 LSSSCVPDSSSLSSLGDSSFYR-----ALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSS 1530
Query: 753 LTLRHMKDQNKKVANLKHNQQLEK--KKNAQLLEEVRRREDSMADNSQHLQIEELMNALE 810
L ++ + A K ++LE + Q LE++ + +S ++ +I+EL L
Sbjct: 1531 LQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQG-IMKNKEIQELEQLLS 1589
Query: 811 KTRQELDATKARLAST----QQSLAEKEAHLANLRIERRKQLEEI 851
RQELD + + S QQ L + + +KQ E++
Sbjct: 1590 SERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQL 1634
Score = 77.0 bits (188), Expect = 8e-14
Identities = 111/629 (17%), Positives = 259/629 (41%), Gaps = 62/629 (9%)
Query: 315 KGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTK 374
+GLP+++L+ ++ E E Q+ L+ +E+ R+ QL A +
Sbjct: 10 EGLPTRALQ-------KIQELEGQLDKLK-------------KEKQQRQFQLDSLEAALQ 49
Query: 375 ALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKT 434
+ +E + T+ +L+R + L + + L+ + + + + Q+ + K
Sbjct: 50 KQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKK 109
Query: 435 KIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDA 494
+I++L+QEL + +SEL Q ++ + C ++ LT + + ++
Sbjct: 110 QIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKE 169
Query: 495 LRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQ 554
+ E+ L + K LQ + TL + +D+ + +V + E
Sbjct: 170 KYNKEVEERKRLEAEVKALQ-AKKASQTLPQATMNHRDIAR-HQASSSVFSWQQEKTPSH 227
Query: 555 LRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEAL----------SEKERIIERLKEQR 604
L ++ +D S + + +TL+ S ++++LK Q
Sbjct: 228 LSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN 287
Query: 605 ERDDRERLEEIE-SFRKENKDLKEKVNALQ----------AELTEKESSLIDLKEHASSL 653
+ + R ++ E+E + K++K +VN Q EL EKE L ++
Sbjct: 288 Q-ELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT 346
Query: 654 ASAGLKRDSKLKSLEIAIEQKKEE--CSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKE 711
+ + +K +LE +++ E+ C + A+ + + EF +++ + +
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 712 ASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN 771
EC + +A + + L+ K + N + K+ ++ ++++ +K+ +
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
Query: 772 QQLEKKKNAQL---LEEVRRREDSMADNSQ-------HLQ-----IEELMNALEKTRQEL 816
Q + K +L +EE+++ + + +S+ HL+ I++ +N + +E+
Sbjct: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 817 DATKARLASTQQSLAEKEAHLAN-LRIERRKQLEEILEMKQEALLAAISEKDANIALLEL 875
A + + L EK N L +E+ K LE +++ + +++ +I L
Sbjct: 527 KAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLND 586
Query: 876 SASKKKKTQEEVMALKREKDRLVHQLKQQ 904
SK +K + +++ K + +LK++
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEE 615
Score = 47.8 bits (112), Expect = 5e-05
Identities = 96/463 (20%), Positives = 174/463 (37%), Gaps = 67/463 (14%)
Query: 500 EEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKD 559
E KE + +++Q+L + L E + + L+ E + ++K+EN + + +
Sbjct: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
Query: 560 KQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFR 619
++ L + +SL+ L E ++ +E + K+Q E+ ++E +
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE-------LK 119
Query: 620 KENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECS 679
+ +L+ A Q+ K + L + SK + L+ ++ EE
Sbjct: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Query: 680 KLEA-----QLKKAHNIEDDSRMN---------------------PEFADQIKQ-----L 708
+LEA Q KKA + MN P Q
Sbjct: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239
Query: 709 DKEASYYRDE-----------CGKAQA-----EVDRLLEILKEVENEKNDKDKKIAELES 752
D ASY+ E GK A + +L +++ + + KI ELE
Sbjct: 240 DFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299
Query: 753 LTLRHMKDQNKKVANLKHNQ-QLEKKKNAQLLEEV----RRREDSMADNSQHLQIEELMN 807
H K+ +V + Q QLEK K +L+E+ + R++ + +Q+ Q
Sbjct: 300 RLQGHEKEMKGQVNKFQELQLQLEKAK-VELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 808 ALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKD 867
ALE Q+L L+ +Q+ L E+ K+ +E L +Q + E
Sbjct: 359 ALE---QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECI 415
Query: 868 ANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMK 910
A L + K L+ E D+L +KQQ +N ++
Sbjct: 416 QMKARLTQELQQAKNMHN---VLQAELDKLT-SVKQQLENNLE 454
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 127 bits (318), Expect = 6e-29
Identities = 178/777 (22%), Positives = 350/777 (45%), Gaps = 122/777 (15%)
Query: 197 RKEEAARMSVLK-EQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFT 255
+K E R ++ + E +RV E N+ L+ + +++EL+ +++ ++ N+ HF
Sbjct: 822 KKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKE-----EKAELNKQIVHFQ 876
Query: 256 IELT---------EENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIK 306
EL+ + +++Q+ +D EL + + +E E +I + SI
Sbjct: 877 QELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSIT 936
Query: 307 KLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVI-----LDQKEKENI------- 354
+ ++ L R ++ SQ+S+++++ + E++N+
Sbjct: 937 NNVSQIKLMHTKIDEL--------RTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDL 988
Query: 355 ----HLREELHRRSQLQPEPAKTKALQTVIEM-----KDTKIASLERN--IRDLEDEIQM 403
+L + + ++Q EP + + + IE K+ AS +++ I +LE +I+
Sbjct: 989 LGNDYLVSKQVKEYRIQ-EPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEK 1047
Query: 404 LKANGVLNTEDREEEIKQIEVYKSHSKFMKTK---IDQLKQELSKKE------------- 447
L+A V +D +K+ E +K+ +K K I QLK+EL +K
Sbjct: 1048 LQAE-VKGYKDENNRLKEKE-HKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEG 1105
Query: 448 ----SELLALQT-------KLET-LSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDAL 495
SEL T +LET L Q +C H L++ + KE + IL+ E +
Sbjct: 1106 KRALSELTQGVTCYKAKIKELETILETQKVECS-HSAKLEQDILEKE--SIILKLERNLK 1162
Query: 496 RLRLEEKESFLNKKTKQLQDLT--EEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQE 553
+ ++S N K +++L EE L ++DMK +L++KE + +++ E L+E
Sbjct: 1163 EFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKE 1222
Query: 554 QLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLE 613
+L + NLK ++ + D A L+E L++ ++ I+++++
Sbjct: 1223 ELSASSARTQNLKADLQRKEED-------YADLKEKLTDAKKQIKQVQK----------- 1264
Query: 614 EIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQ 673
E+ R E+K L+ K+N L+ + + L D+K+ LK + +E AI+Q
Sbjct: 1265 EVSVMRDEDKLLRIKINELEKKKNQCSQEL-DMKQRTIQQ----LKEQLNNQKVEEAIQQ 1319
Query: 674 KKEECSKLEAQLKKAHNIEDDSRMNPEFADQIK-QLDKEASYYRDECGKAQAEVDRLLEI 732
+ C L + K I +D RM E +Q + + D+ +E + E+++ E
Sbjct: 1320 YERACKDLNVKEK----IIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEK 1375
Query: 733 LKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN-QQLEKKKNAQLLE--EVRRR 789
++E + N + K E E+ T D K+ NL+ Q+ E+K NA + E +
Sbjct: 1376 CNDLETKNNQRSNK--EHENNT-----DVLGKLTNLQDELQESEQKYNADRKKWLEEKMM 1428
Query: 790 EDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLE 849
+ A +++++ +E+ E R+ + + L EK++ L R E R QL
Sbjct: 1429 LITQAKEAENIRNKEMKKYAED-RERFFKQQNEMEILTAQLTEKDSDLQKWR-EERDQLV 1486
Query: 850 EILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQ 906
LE++ +AL+++ +KD I L+ S+ K + ++M +K ++ K QT+
Sbjct: 1487 AALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTE 1543
Score = 116 bits (290), Expect = 1e-25
Identities = 176/816 (21%), Positives = 348/816 (42%), Gaps = 101/816 (12%)
Query: 154 LKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRV 213
++EL+ + E + D L ++ K F S E K++ + E+ + + +++ ++
Sbjct: 536 VEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKL 595
Query: 214 SHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQA----- 268
+ E ++T + Q + + D L QE E+ EEN R A
Sbjct: 596 TLEFKIREEVTQEFTQYWAQREADFKETLLQER----------EILEENAERRLAIFKDL 645
Query: 269 -----EHDRQAKELFLLRKTLEE----MELRIETQKQTLNARDESIKKLLEMLQSKGLPS 319
+ AK++ + EE +EL+ K L + K E L+ + S
Sbjct: 646 VGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENES 705
Query: 320 KSLEDDNERTRRMAEAESQ-VSHLEVILDQKE---KENIHLREELHRRSQLQPEPAKTKA 375
SL + E + + ++Q + L I+DQKE E +L+ + + + A T +
Sbjct: 706 DSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCN-DKADTSS 764
Query: 376 L---------QTVIEMKD--TKIASLERNIRDLE---DEIQMLKANGVLNTEDREEEIKQ 421
L +TV KD +KI S + + + E DE K + +++ E++ K
Sbjct: 765 LIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKS 824
Query: 422 IEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAK 481
EV + ++ ++ L++ + LL ++ +L+ + ++ + I ++ L+
Sbjct: 825 EEVRPNIAEIEDIRV--LQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLS 882
Query: 482 EQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKI 541
E++ L EV ++ + + L+ + + Q+ E+ L+ EI + +I
Sbjct: 883 EKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQI 942
Query: 542 NVLQKKIENLQ-----EQLRDKDKQLTNLKDRVKSLQTDS-SNTDTALATLEEALSEKER 595
++ KI+ L+ Q+ + D L NL+D + D+ NT L + +S++ +
Sbjct: 943 KLMHTKIDELRTLDSVSQISNID--LLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVK 1000
Query: 596 IIERLKEQRERDDRERLEEIESFRKE-----------NKDLKEKVNALQAELT--EKESS 642
+ RE +E I KE ++L++++ LQAE+ + E++
Sbjct: 1001 EYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENN 1060
Query: 643 LIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK-KAHNIEDDSRMNPEF 701
+ KEH + +D LK E I+Q KEE + L + ++ + R E
Sbjct: 1061 RLKEKEHKN--------QDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSEL 1112
Query: 702 ADQIKQLDKEASYYRDECGKAQ-AEVDRLLEILKEVENEKNDKDKKIAELESLTL---RH 757
+ C KA+ E++ +LE K + ++ I E ES+ L R+
Sbjct: 1113 TQGV------------TCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERN 1160
Query: 758 MKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEE-----LMNALEKT 812
+K+ + + + N + K +L EE+ + +++ D LQ++E EK
Sbjct: 1161 LKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKL 1220
Query: 813 RQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIAL 872
++EL A+ AR + + L KE A+L+ + ++I ++++E + +K I +
Sbjct: 1221 KEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKI 1280
Query: 873 LELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNR 908
EL K + +QE M K R + QLK+Q N+
Sbjct: 1281 NELEKKKNQCSQELDM-----KQRTIQQLKEQLNNQ 1311
Score = 115 bits (288), Expect = 2e-25
Identities = 200/859 (23%), Positives = 367/859 (42%), Gaps = 167/859 (19%)
Query: 147 MLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSV 206
++ + +LK+ + E+D L +EL+ + K+ + IK + +KE + +
Sbjct: 691 LIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINE-----FQN 745
Query: 207 LKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRL 266
LK M + + N + + ++L + E E N L
Sbjct: 746 LKSHMENTFKCNDKADTSSLIINNKLICNETV------EVPKDSKSKICSERKRVNENEL 799
Query: 267 QAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDN 326
Q + K + + E + + E + + A E I+ L E ++GL + L +N
Sbjct: 800 QQDEPPAKKGSIHVSSAITEDQKKSEEVRPNI-AEIEDIRVLQE--NNEGLRAFLLTIEN 856
Query: 327 E---RTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMK 383
E AE Q+ H + L EK+N+ L +K +Q +
Sbjct: 857 ELKNEKEEKAELNKQIVHFQQELSLSEKKNLTL----------------SKEVQQIQSNY 900
Query: 384 DTKIASLE-RNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLK-- 440
D IA L + ++ E E +++K + + T R I S K M TKID+L+
Sbjct: 901 DIAIAELHVQKSKNQEQEEKIMKLSNEIETATR-----SITNNVSQIKLMHTKIDELRTL 955
Query: 441 --------------QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAA 486
++LS E T+L+ L N KQ +KE + R
Sbjct: 956 DSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQ----VKEYRIQEPNREN 1011
Query: 487 ILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD---MLEVKERK--I 541
+ ++A+ +E +KK+ Q+++L ++ L E++ KD L+ KE K
Sbjct: 1012 SFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQD 1071
Query: 542 NVLQKK---IENLQEQLRDKDKQL---------------------TNLKDRVKSLQT--D 575
++L++K I+ L+E+L++K+ L T K ++K L+T +
Sbjct: 1072 DLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILE 1131
Query: 576 SSNTDTA-LATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQA 634
+ + + A LE+ + EKE II +L ER+ +E E ++ K KDL K L+
Sbjct: 1132 TQKVECSHSAKLEQDILEKESIILKL----ERNLKEFQEHLQDSVKNTKDLNVKELKLKE 1187
Query: 635 ELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDD 694
E+T+ ++L D+K H L ++ + ++ E+ KEE L A + N++ D
Sbjct: 1188 EITQLTNNLQDMK-HLLQL------KEEEEETNRQETEKLKEE---LSASSARTQNLKAD 1237
Query: 695 -SRMNPEFAD----------QIKQLDKEASYYRDECGKAQAEVDRLLEI-LKEVENEKND 742
R ++AD QIKQ+ KE S RDE D+LL I + E+E +KN
Sbjct: 1238 LQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDE--------DKLLRIKINELEKKKNQ 1289
Query: 743 KDKKIAELESLTLRHMKDQ--NKKVAN-LKHNQQLEKKKNA--QLLEEVR----RREDSM 793
+++ +++ T++ +K+Q N+KV ++ ++ K N +++E++R +E +
Sbjct: 1290 CSQEL-DMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQ 1348
Query: 794 ADNSQHL-----QIEELMNALEKTRQELDATKARLASTQQSLAEKE------AHLANLRI 842
+ Q L ++E L LEK +++ + + + + Q+S E E L NL+
Sbjct: 1349 VEQDQVLEAKLEEVERLATELEKWKEKCNDLETK--NNQRSNKEHENNTDVLGKLTNLQD 1406
Query: 843 E-----------RRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALK 891
E R+K LEE + +L +++ NI E+ K + +E +
Sbjct: 1407 ELQESEQKYNADRKKWLEE------KMMLITQAKEAENIRNKEM--KKYAEDRERFFKQQ 1458
Query: 892 REKDRLVHQLKQQTQNRMK 910
E + L QL ++ + K
Sbjct: 1459 NEMEILTAQLTEKDSDLQK 1477
Score = 107 bits (266), Expect = 7e-23
Identities = 147/731 (20%), Positives = 315/731 (43%), Gaps = 94/731 (12%)
Query: 148 LDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVL 207
L L +++++Q D+ EL ++ SK + ++E++++ +
Sbjct: 887 LTLSKEVQQIQSNYDIAIAELHVQKSK-------------NQEQEEKIMKLSNEIETATR 933
Query: 208 KEQMRVSHEENQHLQLTIQALQDELRTQRDLNH-----LLQQESGNRGAEHFTIELTEEN 262
VS + H ++ DELRT ++ LL + G+E E+N
Sbjct: 934 SITNNVSQIKLMHTKI------DELRTLDSVSQISNIDLLNLRDLSNGSE-------EDN 980
Query: 263 FRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESI-KKLLEMLQSKGLPSKS 321
Q + +L+ K ++E ++ ++ + ++ E+I ++ E++++ S
Sbjct: 981 LPNTQLD---LLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQ 1037
Query: 322 LEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIE 381
+E E E Q+ L+ + + EN L+E+ H+ +++
Sbjct: 1038 IE----------ELEQQIEKLQAEVKGYKDENNRLKEKEHKNQD------------DLLK 1075
Query: 382 MKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKID---- 437
K+T I L+ +++ + + + V E + + YK+ K ++T ++
Sbjct: 1076 EKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKV 1135
Query: 438 ------QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLK-ESLTAKEQRAAILQT 490
+L+Q++ +KES +L L+ L+ D ++ + L + L KE+ +
Sbjct: 1136 ECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNN 1195
Query: 491 EVDALRL-RLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIE 549
D L +L+E+E N++ + + L EE + +++K L+ KE L++K+
Sbjct: 1196 LQDMKHLLQLKEEEEETNRQ--ETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLT 1253
Query: 550 NLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDR 609
+ ++Q++ K+++ ++D K L+ + + + L K+R I++LKEQ
Sbjct: 1254 DAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKV 1313
Query: 610 ERLEEIESFRKENKDL--KEK-VNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKS 666
E E I+ + + KDL KEK + ++ L E+E + ++ + A L+ +++
Sbjct: 1314 E--EAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVE----QDQVLEAKLE---EVER 1364
Query: 667 LEIAIEQKKEECSKLEAQLKKAHNIEDDSRMN--PEFADQIKQLDKEASYYRDECGKAQA 724
L +E+ KE+C+ LE + + N E ++ + + + +L + Y + K
Sbjct: 1365 LATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLE 1424
Query: 725 EVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQ---QLEKKKNAQ 781
E L+ KE EN +N + KK AE + + A L Q +++ Q
Sbjct: 1425 EKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQ 1484
Query: 782 LLE--EVRRREDSMADNSQHLQIEELMNALEKT----RQELDATKARLASTQQSLAEKEA 835
L+ E++ + ++ + +IE+L + +T Q +D R++S + E
Sbjct: 1485 LVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEP 1544
Query: 836 HLANLRIERRK 846
+ I R K
Sbjct: 1545 LSTSFEISRNK 1555
Score = 80.5 bits (197), Expect = 7e-15
Identities = 146/757 (19%), Positives = 299/757 (39%), Gaps = 137/757 (18%)
Query: 262 NFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKS 321
N +R + ++L +EE+E ETQ DE + K LE ++K S
Sbjct: 514 NVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLE--ENKAFIS-- 569
Query: 322 LEDDNERTRRMAEAESQVSHLEVILDQKEKENIH--LREELHRRSQLQPEPAKTKALQTV 379
+E R++ + + ++I ++KEK + +REE+ + + +T+
Sbjct: 570 ----HEEKRKLLDLIEDLKK-KLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETL 624
Query: 380 IEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSK----FMKTK 435
++ ++ + ER + +D + + REE K I K ++ ++ K
Sbjct: 625 LQEREILEENAERRLAIFKDLVG--------KCDTREEAAKDICATKVETEEATACLELK 676
Query: 436 IDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDAL 495
+Q+K EL+K + EL+ + +L+ N++ Q +E + + + QR L +D
Sbjct: 677 FNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQK 736
Query: 496 RLRLEEKESFLN--KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQE 553
+ E ++ + + T + D + + + +EV + + KI + ++
Sbjct: 737 EDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDS----KSKICSERK 792
Query: 554 QLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERL- 612
++ + + Q + S+ S+ T+ + E + E IE ++ +E ++ R
Sbjct: 793 RVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAE--IEDIRVLQENNEGLRAF 850
Query: 613 -----EEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSL-------------- 653
E+++ ++E +L +++ Q EL+ E + L + +
Sbjct: 851 LLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQ 910
Query: 654 ASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLD---- 709
S +++ K+ L IE + +Q+K H D+ R + QI +D
Sbjct: 911 KSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELR-TLDSVSQISNIDLLNL 969
Query: 710 ---------------------------KEASYYR----DECGKAQAEVDRLLEILKEVEN 738
K+ YR + + ++ + E KE+
Sbjct: 970 RDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVK 1029
Query: 739 EKNDKDKKIAELE------SLTLRHMKDQNKKVANLKHNQQ--LEKKKNA---QLLEEVR 787
+ K +I ELE ++ KD+N ++ +H Q L K+K QL EE++
Sbjct: 1030 ASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQ 1089
Query: 788 RREDSMADNSQHLQIEELMNALEKTRQELDATKARL-----------------ASTQQSL 830
+ ++ QH + E AL + Q + KA++ A +Q +
Sbjct: 1090 EKNVTLDVQIQH--VVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDI 1147
Query: 831 AEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKT------- 883
EKE+ + L++ER L+E E Q+++ + KD N+ L+L + T
Sbjct: 1148 LEKESII--LKLER--NLKEFQEHLQDSVK---NTKDLNVKELKLKEEITQLTNNLQDMK 1200
Query: 884 ------QEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
+EE ++E ++L +L + L AD
Sbjct: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLKAD 1237
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 126 bits (317), Expect = 8e-29
Identities = 189/883 (21%), Positives = 382/883 (43%), Gaps = 159/883 (18%)
Query: 145 STMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARM 204
+++ ++AQLKE++ E + EL++K S S + K E V + +E
Sbjct: 1302 TSVAQIKAQLKEIEAE----KVELELKVSSTTSELTK---------KSEEVFQLQEQINK 1348
Query: 205 SVLK-EQMR-VSHEENQHLQLTIQALQ-------------------DEL-----RTQRDL 238
L+ E ++ VSHE H + Q L+ DEL + + D+
Sbjct: 1349 QGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDV 1408
Query: 239 NHLLQQESGNRGA-EHFTIELTEEN--FRRLQAEHDRQAKE----LFLLRKTLEEMELRI 291
++L Q S A E+ E+ + L + + QAKE + L+ L EM+ +
Sbjct: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
Query: 292 ETQKQTLNARDESIKKLLEMLQSKG---LPSKSLEDD--------NERTRRMAEAESQVS 340
E + A+ + +KL L S+ +KSL+++ T+ +A+ ESQVS
Sbjct: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
Query: 341 HLEVILDQKEKENIH-----LREELHRR-SQLQPEPAKTKALQTVIEMKDTKIASLERNI 394
KEK+ + L+EE + +++ + ++L + E + L +
Sbjct: 1529 -----AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
Query: 395 RDLEDEIQMLKANGVLNTEDREEEIKQI-----------EVYKSHSKFMKTKIDQLKQEL 443
L EI+ LK++ + + + +E+ K++ E + ++ ++ ++ ++QE
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643
Query: 444 SKKESELLALQTKLETLSNQNSDCKQHIEVLKESLT--AKEQRAAILQTEVDALRLRLEE 501
+ +L + + + Q + +Q +E +KE + AK ++ IL+ E + RLR E
Sbjct: 1644 QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703
Query: 502 K----------ESFLNKK-----------------TKQLQDLTEEKGTLAGEIRDMKDML 534
E+ L+ +K+ Q L EK +L+ E++D+K +
Sbjct: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 535 EVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKE 594
E K Q +E ++ D Q ++ +S+ ++ D+ + SE
Sbjct: 1764 EGNVSK----QANLEATEKH----DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESV 1815
Query: 595 RIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLA 654
+ +D +EI ++ ++ LKE++ L+ E + + L+ ++L
Sbjct: 1816 PSAKSANPAVSKDFSSH-DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLL 1874
Query: 655 SAGLKRDSKLKSLEIAI-------EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQ 707
S +D +LK L+ + +Q +EE S++ + A +DD + +Q+ +
Sbjct: 1875 SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDD--LEERLMNQLAE 1932
Query: 708 LDKEASYYRDECGKAQ-------AEVDRLLEILKEVENEK----NDKDKKIAELESLTLR 756
L+ Y + AQ +E+ L + + E+E EK +K K +E+ L
Sbjct: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
Query: 757 HMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALE----KT 812
++ K+ N H ++L++ + E + ++D + + +E + ALE ++
Sbjct: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
Query: 813 RQELDATKARLASTQQSLAEKEAHLANLRI-------ERRKQLEEILEMK------QEAL 859
+++L+ TK LA + + +A LA+ ++ E + L + L++K +E++
Sbjct: 2053 QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112
Query: 860 LAAISEKDANI-ALLELSASK----KKKTQEEVMALKREKDRL 897
+ + +KD ++ LE + K KK QE++ AL+REK L
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHL 2155
Score = 116 bits (291), Expect = 9e-26
Identities = 176/824 (21%), Positives = 341/824 (41%), Gaps = 123/824 (14%)
Query: 156 ELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLR---KEEAARMSVLKEQMR 212
EL+ + L KE + KL ++ S K +KER LR K++ + L+EQ
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFD 1220
Query: 213 VSHEENQHLQLTIQALQDELRTQRD--LNHLLQQES--GNRGAE---------HFTIELT 259
+EN+++ ++ LQ ++R D L QQES G E H T +
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVL 1280
Query: 260 EENFRRLQAEHDRQAK-------------ELFLLRKTLEEMELRIETQKQTLNARDESIK 306
E N H A +L + E+EL++ + L + E +
Sbjct: 1281 ESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVF 1340
Query: 307 KLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENI---HLREELHRR 363
+L E + +GL +SL+ + EAE L+ L+ + + HLRE +
Sbjct: 1341 QLQEQINKQGLEIESLKTVSH------EAEVHAESLQQKLESSQLQIAGLEHLRELQPKL 1394
Query: 364 SQLQPEPAKTKA----LQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEI 419
+LQ +K + L + K+ + ++ I + ED I+ L + ++ +E I
Sbjct: 1395 DELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERI 1454
Query: 420 KQIEVYKSHSKFMKTKIDQ---LKQELSKK-ESELLALQTKLE---TLSNQNSDCKQHIE 472
KQ++V K +I + KQ++ +K ++ L++ + L+ +L + S + IE
Sbjct: 1455 KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
Query: 473 VLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 532
L +SL E + + E D + RL + +K ++ E +L+ +K
Sbjct: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574
Query: 533 MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSE 592
LE L K+IE+L+ K + T +++ K LQ + + L + E +E
Sbjct: 1575 ALEGLTEDKEKLVKEIESLKSS---KIAESTEWQEKHKELQKEY---EILLQSYENVSNE 1628
Query: 593 KERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASS 652
ERI +E+ R+E ++L K+ + +A E E L + ++
Sbjct: 1629 AERI---------------QHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEE 1673
Query: 653 LASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEA 712
+ K KS + I + +EE +L A++ A + + ++ L
Sbjct: 1674 MKE---KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKEC---------METLLSSN 1721
Query: 713 SYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQ 772
+ ++E + + E + L + + + +EK+ +++ +L+ ++ Q A KH+
Sbjct: 1722 ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDN 1781
Query: 773 QLE-KKKNAQLLEEVRRREDSMADNSQHLQIEELMNA----------------LEKTRQE 815
Q ++ Q + +DS++ +++ E + +A + Q+
Sbjct: 1782 QTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQ 1841
Query: 816 LDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLEL 875
+D K R+A ++ EK+ + K+ + LE ++ LL+ IS KD + +L
Sbjct: 1842 IDQLKERIAGLEE---EKQ---------KNKEFSQTLENEKNTLLSQISTKDGELKML-- 1887
Query: 876 SASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDD 919
QEEV + ++ +L + T ++K A+ DD
Sbjct: 1888 --------QEEVTKMNLLNQQIQEELSRVT--KLKETAEEEKDD 1921
Score = 113 bits (282), Expect = 1e-24
Identities = 156/787 (19%), Positives = 336/787 (42%), Gaps = 106/787 (13%)
Query: 149 DLQAQLKELQR-----ENDLLRKELDIKDSK--LGSSMNSIKTFWSPELKKERVLRKEEA 201
+L +QL+E + +N+L + E ++K K L NS++ + E ++R++EA
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 202 ARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTI----- 256
+ Q+ + + + L+ +L+ R+L L +E + + ++
Sbjct: 2348 ---------------DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE 2392
Query: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 316
E + L+ +HD++ KEL L EE + +E + + + + + L+ ++ +
Sbjct: 2393 EAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
Query: 317 LPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKAL 376
+ K+ D ++ + + ++ D ++ E HL L + +Q A+ L
Sbjct: 2453 IQQKAQLDSFVKSMSSLQNDRD----RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL 2508
Query: 377 QTVIEMKDTKIASLERNIRDLEDEIQMLKA--NGVLNTEDREEEIKQIEVYKSHSKFMKT 434
+ I + + L L+ E+ + N V+ +D +++ + +EV +K ++
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQK-QLLEVQLQQNKELEN 2567
Query: 435 KIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTE--- 491
K +L+++L + E L+ L + D + IE LK S++ ++ LQ E
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTL 2627
Query: 492 -VDALRLRLEEKE-----SFLNKKTKQLQDLTEE-------KGTLAGEIRD-MKDMLEVK 537
+ +L+++E+E + + K++ +L EE GEI D +K L+
Sbjct: 2628 GLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL 2687
Query: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERII 597
+++ + E +E++ + + L ++ ++ + ++ + + ++S
Sbjct: 2688 HHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSL---- 2743
Query: 598 ERLKEQRERDD-RERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASA 656
Q RD E L+E++ RK + LKE + L +E + L E A S+ S
Sbjct: 2744 -----QNSRDHANEELDELK--RKYDASLKELAQLKEQGLLNRERDAL-LSETAFSMNST 2795
Query: 657 GLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYR 716
S L+ L + K E+ L +QL+ ++N Q++ K +
Sbjct: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN-------------QVQSFSKAMA--- 2839
Query: 717 DECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK 776
Q E D L L++ + K + A+ S + ++ K +++L++++
Sbjct: 2840 ----SLQNERDHLWNELEKFRKSEEGKQRSAAQ-PSTSPAEVQSLKKAMSSLQNDRD--- 2891
Query: 777 KKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQEL----DATKARLASTQQSLAE 832
+LL+E++ + Q+LQI + + L + +L D TKA ++ E
Sbjct: 2892 ----RLLKELKNLQQ------QYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
Query: 833 K---EAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMA 889
+ L LR+E+ MK++ L+A IS+KD ++ L+ + + + +
Sbjct: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMA-ISDKDQQLSHLQNLIRELRSSSSQTQP 3000
Query: 890 LKREKDR 896
LK + R
Sbjct: 3001 LKVQYQR 3007
Score = 112 bits (280), Expect = 2e-24
Identities = 182/862 (21%), Positives = 362/862 (41%), Gaps = 169/862 (19%)
Query: 151 QAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQ 210
Q ++ EL+ END LR E+ M + L KEE R+ + E
Sbjct: 1686 QQKILELEEENDRLRAEVHPAGDTAKECMET--------LLSSNASMKEELERVKMEYET 1737
Query: 211 MRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFT------IELTEENFR 264
+ ++ Q L +L +E++ DL H ++ + T +TEE +
Sbjct: 1738 LS---KKFQSLMSEKDSLSEEVQ---DLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791
Query: 265 RLQAEHDRQAKELFLLRKTLEEM-----------------ELRIETQKQTLNARDESIKK 307
+ E + Q R T E I Q ++ E I
Sbjct: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAG 1851
Query: 308 LLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENI---HLREELHRRS 364
L E Q S++LE NE+ +++ ++ L+++ ++ K N+ ++EEL R +
Sbjct: 1852 LEEEKQKNKEFSQTLE--NEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
Query: 365 QLQPEPAKTKA--------------------------LQTVIEMKDTKIASLERNIRDLE 398
+L+ + K Q E+ ++++ +L++ + +LE
Sbjct: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 399 DEIQML-KANGVLNTEDREEEIKQIEVY------KSHSKFMKTKIDQLKQELSKKESELL 451
+E Q L K + +E R+E +++I+ KSH+K ++ + + +QE+ + + + +
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029
Query: 452 ALQTKLETLSNQ-------NSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKES 504
Q K+ L ++ ++ +E+ KE+L + Q E+ + ++ L++ +S
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089
Query: 505 ----FLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE----------VKERK-----INVLQ 545
L K ++L K ++ +++ + LE +KE+K ++ L+
Sbjct: 2090 EAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR 2149
Query: 546 KKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRE 605
++ +L+E + + L V+ LQ + +T T LA +++S +
Sbjct: 2150 REKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQ----------- 2198
Query: 606 RDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLK 665
DDR+R+ I+ +K + + + + + E+ KE + LK+ +L+
Sbjct: 2199 -DDRDRV--IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD--------------QLR 2241
Query: 666 SLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAE 725
+ I +E+ K S+L E D ++ A QL ++ C Q E
Sbjct: 2242 QMSIHMEELKINISRL----------EHDKQIWESKAQTEVQLQQKV------CDTLQGE 2285
Query: 726 VDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK-KKNAQLLE 784
LL L+E + + ++A+LES L+ +KDQ ++N LEK K+ LE
Sbjct: 2286 NKELLSQLEETRHLYHSSQNELAKLES-ELKSLKDQLTDLSN-----SLEKCKEQKGNLE 2339
Query: 785 EVRRREDSMADNSQHLQIEELMNALEKTR-------QELDATKARLASTQQSLAEK-EAH 836
+ R++++ NS+ E+L L+ +R +E++ + ++ S E +
Sbjct: 2340 GIIRQQEADIQNSK-FSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Query: 837 LANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDR 896
+A LR + K+++E+ E LL+ E++ NI L E + KT + + LK K
Sbjct: 2399 IAELRQQHDKEIKEL-----ENLLS--QEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451
Query: 897 LVHQLKQQTQNRMKLMADNYDD 918
+ Q K Q + +K M+ +D
Sbjct: 2452 NIQQ-KAQLDSFVKSMSSLQND 2472
Score = 110 bits (275), Expect = 6e-24
Identities = 159/809 (19%), Positives = 331/809 (40%), Gaps = 83/809 (10%)
Query: 139 LRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRK 198
LRQ D + +L+ L + + EN +L +E K M ++KT +KKE + +
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT-----IKKENI--Q 2454
Query: 199 EEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIEL 258
++A S +K + ++ ++ + Q + L + + L+Q+ + I
Sbjct: 2455 QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRG 2514
Query: 259 TEENFRRLQAEHDRQAKELFLLRKTLEE-MELRIETQKQTLNARDESIKKLLEMLQSKGL 317
+ L +E+ + EL R+ L + + ++ QKQ L + + K+L
Sbjct: 2515 LRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE 2574
Query: 318 PSKSLEDDNERTRRMAEA--------ESQVSHLEVILDQKEKENIHLREELHRRSQLQPE 369
K E+ NE RR A ++ L+V + Q ++ L+EE L
Sbjct: 2575 KLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE----GTLGLY 2630
Query: 370 PAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSH- 428
A+ K + + +S ++ I +LE+E+ ++ + E+++K+ + H
Sbjct: 2631 HAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHD 2690
Query: 429 SKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAIL 488
+ M+ + + ++ +++ +L+ ++ KL ++ +N I+ S+++ +
Sbjct: 2691 AGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHA 2750
Query: 489 QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKI 548
E+D L+ + + L + K+ L E+ L E M +E ++ L+K
Sbjct: 2751 NEELDELKRKYDASLKEL-AQLKEQGLLNRERDALLSE--TAFSMNSTEENSLSHLEK-- 2805
Query: 549 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDD 608
L +QL KD+QL +L +++ + A+A+L+ +E+ ++ E
Sbjct: 2806 --LNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQ 2863
Query: 609 RERLE------EIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSL--ASAGLKR 660
R + E++S +K L+ + L EL + + + + + L A L+
Sbjct: 2864 RSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQE 2923
Query: 661 -DSKLKSLEIAIEQKKEECSKLEAQL-----KKAHNIEDDSRMNPEFADQIKQLDKEASY 714
K K+ +I E+ ++E + +L +K+ + RM ++ I D++ S+
Sbjct: 2924 YQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH 2983
Query: 715 YRDECGKAQAEVDRLLEILKEVENEKN-------DKDKKIAELESLTLRHMKDQNKKVAN 767
++ + ++ + + + + + + D + + L + D K++
Sbjct: 2984 LQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ 3043
Query: 768 LKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ-----IEELMN---ALEKTRQELDA- 818
+ Q +QLLEE + D SQ L+ +L+N LEK QEL A
Sbjct: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAG 3103
Query: 819 ---------------------TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQE 857
L QQS +E + L N R + +L ++LE +++
Sbjct: 3104 PLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTR-QEVNELRKLLEEERD 3162
Query: 858 ALLA---AISEKDANIALLELSASKKKKT 883
+A A+S + I LE S +T
Sbjct: 3163 QRVAAENALSVAEEQIRRLEHSEWDSSRT 3191
Score = 108 bits (270), Expect = 2e-23
Identities = 193/891 (21%), Positives = 371/891 (41%), Gaps = 166/891 (18%)
Query: 133 HQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWS----- 187
++V S L+Q D Q +ELQ E DLL+KE + + KL +++ + K
Sbjct: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRL 1012
Query: 188 --------PELKKERVLRKEEAARMSVLKEQMRVSH-------------------EENQH 220
E KKE L + E + KE S E+
Sbjct: 1013 EEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVE 1072
Query: 221 LQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDR-------- 272
LQ + L+++L + L++Q + + I+L + QA +
Sbjct: 1073 LQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDA 1132
Query: 273 -QAKELFLLRKT-----------------LEEMELRIETQKQTLNARDESIKKLLEMLQS 314
+ L+++T LEE L +E +K+ L KKL E L S
Sbjct: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQ------KKLQEALTS 1186
Query: 315 -KGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKT 373
K + K+ E + + + + + L+ D++ KEN ++ ++L R+ Q+Q
Sbjct: 1187 RKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL-RQLQIQ------ 1239
Query: 374 KALQTVIEMKDTKIASLER-----NIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSH 428
V E D K+ S ++ + LE+ + KA +T+ E + SH
Sbjct: 1240 -----VRESIDGKLPSTDQQESCSSTPGLEEPL--FKATEQHHTQPVLES-NLCPDWPSH 1291
Query: 429 SKFMK-----TKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQ 483
S+ T + Q+K +L + E+E + L+ K+ + +++ LT K +
Sbjct: 1292 SEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSE--------------LTKKSE 1337
Query: 484 RAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINV 543
LQ +++ L +E ++ ++ + L ++ + +I ++ + E
Sbjct: 1338 EVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRE-------- 1389
Query: 544 LQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQ 603
LQ K++ LQ+ + K++ ++ L ++ S + AL ++ + E+E +I+ L Q
Sbjct: 1390 LQPKLDELQKLISKKEEDVSYLSGQL-------SEKEAALTKIQTEIIEQEDLIKALHTQ 1442
Query: 604 RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSK 663
E +E E I+ + E ++K+K + E K+ L+ S A + S
Sbjct: 1443 LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSL 1502
Query: 664 LKSLEIA---IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
+ L +A IE+ + + +E+Q+ A N E D+ + ++ L +E E
Sbjct: 1503 QEELSLARGTIERLTKSLADVESQV-SAQNKEKDTVLG-----RLALLQEERDKLITEMD 1556
Query: 721 KAQAEVDRL---LEILK-EVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEK 776
++ E L E LK +E DK+K + E+ESL ++ K+A Q+ K
Sbjct: 1557 RSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL-------KSSKIAESTEWQEKHK 1609
Query: 777 --KKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKE 834
+K ++L + + A+ QH+ +E + ++ +L +T+A T++ L E E
Sbjct: 1610 ELQKEYEILLQSYENVSNEAERIQHV-VEAVRQEKQELYGKLRSTEANKKETEKQLQEAE 1668
Query: 835 AHLANLRIERRK----QLEEILEMKQE--ALLAAI-----SEKDANIALLELSASKKKKT 883
+ ++ + RK + ++ILE+++E L A + + K+ LL +AS K++
Sbjct: 1669 QEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEEL 1728
Query: 884 Q----------EEVMALKREKDRL---VHQLKQQTQNRMKLMADNYDDDHH 921
+ ++ +L EKD L V LK Q + + A+ + H
Sbjct: 1729 ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH 1779
Score = 106 bits (264), Expect = 1e-22
Identities = 158/810 (19%), Positives = 345/810 (42%), Gaps = 100/810 (12%)
Query: 144 DSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSP------ELKK----- 192
+ T+ ++Q L + +E L++ LD ++L + S+ + E KK
Sbjct: 2156 EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKF 2215
Query: 193 -ERVLRKEEAARM-----SVLKEQMRVSHEENQHLQLTIQAL-----------QDELRTQ 235
+ + KEE R+ SVLK+Q+R + L++ I L Q E++ Q
Sbjct: 2216 SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQ 2275
Query: 236 RDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQK 295
+ + LQ E+ ++ +E T + Q E + EL L+ L ++ +E K
Sbjct: 2276 QKVCDTLQGENKELLSQ---LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCK 2332
Query: 296 QTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIH 355
+ + I++ +Q+ + LE D + +R + S L ++ KE++ I
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT------SRLHEEINMKEQKIIS 2386
Query: 356 LREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDR 415
L Q+ A+ + + D +I LE + E+E N VL E++
Sbjct: 2387 LLSGKEEAIQV--------AIAELRQQHDKEIKELENLLSQEEEE------NIVLEEENK 2432
Query: 416 EEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQ-HIEVL 474
+ K ++ ++ K I Q K +L + +LQ + + ++ H+ ++
Sbjct: 2433 KAVDKTNQLMETLKTIKKENIQQ-KAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSII 2491
Query: 475 KESLTAKEQRAAI---LQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRD-- 529
E ++ AA L+ E+ LR +++ S K +L E+ + I+D
Sbjct: 2492 LEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI-TIKDSQ 2550
Query: 530 MKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEA 589
K +LEV+ ++ L+ K L+E+L++ ++ +L+ +LQ + + + +L+ +
Sbjct: 2551 QKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVS 2610
Query: 590 LSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEH 649
+S+ R + L+E+ + + + K +E+V+ L A + + + +L+E
Sbjct: 2611 ISQLTRQVTALQEE---------GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661
Query: 650 ASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQ----- 704
+ K+ +++ KL+ +LK H+ R E A++
Sbjct: 2662 LVCVQKEAAKKVGEIE-------------DKLKKELKHLHHDAGIMRNETETAEERVAEL 2708
Query: 705 ---IKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQ 761
+ +++++ E A++ + ++N ++ ++++ EL+ R
Sbjct: 2709 ARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK----RKYDAS 2764
Query: 762 NKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKA 821
K++A LK L ++++A LL E +S +NS +E+L L ++L +
Sbjct: 2765 LKELAQLKEQGLLNRERDA-LLSETAFSMNSTEENSLS-HLEKLNQQLLSKDEQLLHLSS 2822
Query: 822 RLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKK 881
+L + + +A+L+ ER E+ + ++ K + A S ++ +
Sbjct: 2823 QLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE-----EGKQRSAAQPSTSPAEVQ 2877
Query: 882 KTQEEVMALKREKDRLVHQLKQQTQNRMKL 911
++ + +L+ ++DRL+ +LK Q +++
Sbjct: 2878 SLKKAMSSLQNDRDRLLKELKNLQQQYLQI 2907
Score = 96.3 bits (238), Expect = 1e-19
Identities = 158/823 (19%), Positives = 333/823 (40%), Gaps = 77/823 (9%)
Query: 141 QVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEE 200
+ + T+L + Q +E ++D E +++ K+ + + S + + E+
Sbjct: 115 KAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ 174
Query: 201 AARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFT-IELT 259
A+ S E+ + ++ Q + I LQ +L +Q QQ + A T + L
Sbjct: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQL-SQTQAEQAAQQVVREKDARFETQVRLH 233
Query: 260 EENFRRLQAEHDRQAK---ELFLLRKTLEEMELR-------IETQKQTLNARDESIKKLL 309
E+ +L + D + + +L +L++ LEE E ++ +Q L A ++ + L
Sbjct: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293
Query: 310 EMLQSKGLPSKSLEDDNERTRR-----MAEAESQVSHLEVILDQKEKENIHLREELHRRS 364
+ LQ +L + E R + + E +V+ ++ ++E HL E+ +
Sbjct: 294 QQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
Query: 365 QLQPE-PAKTKALQ----TVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEI 419
Q Q E ++ AL+ +E K + I SL++ ++L+ LK +D+ E+
Sbjct: 354 QAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQA 413
Query: 420 KQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLT 479
Q I QL+ +L +K E+ +L ++ + +V E
Sbjct: 414 VQ----------SAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ 463
Query: 480 A-KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKE 538
A E+ A LQ V + LE ++ L + +L++L E L+ +I ++ E
Sbjct: 464 AVTEENIASLQKRV----VELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGE 519
Query: 539 RKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIE 598
V + I ++ + R + + + L ++EA E +
Sbjct: 520 ADREVSEISIVDIANK-RSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL 578
Query: 599 RLKEQR-ERDDRERLEEIESFRKENKDLKEKVNALQAELT--------EKESSLIDL-KE 648
+L+ +R E D E L++ E + E + + + E T +ESSL + KE
Sbjct: 579 QLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE 638
Query: 649 HASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDS--RMNPEFADQIK 706
AS+ + + L + ++ K++ K + + D R+ + +
Sbjct: 639 QASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELEL 698
Query: 707 QLDKEASYYRDECGKAQAEVDRLLEILKEVENEKN-----------DKDKKIAELESLTL 755
K Y + E+ L ++++E + + ++D+ +++++ L++
Sbjct: 699 NFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM 758
Query: 756 -----RHMKDQNKKVANLKHNQQLEKKKNAQ----LLEEVRRREDSMADNSQHLQIEELM 806
+K +A + ++L+ + L E++ S+ S+ ++IE L
Sbjct: 759 VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL--SIEAKSKDVKIEVLQ 816
Query: 807 NALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEK 866
N L+ + + + S Q L KE+ + +E +++ I K E L A+S+K
Sbjct: 817 NELDDVQLQFSEQSTLIRSLQSQLQNKESEV----LEGAERVRHI-SSKVEELSQALSQK 871
Query: 867 DANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRM 909
+ I ++ +KK+ E + EKD+ V ++ +M
Sbjct: 872 ELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Score = 94.7 bits (234), Expect = 4e-19
Identities = 165/791 (20%), Positives = 333/791 (42%), Gaps = 113/791 (14%)
Query: 190 LKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRT---QRDLNHLLQQES 246
L+K V + E + + ++ EN+ L I L+ + RT R+++ + +
Sbjct: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532
Query: 247 GNR---GAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEME-LRIETQKQTLNARD 302
N+ AE ++ E F + +H + L +++ EE+ L+++ Q + D
Sbjct: 533 ANKRSSSAEESGQDVLENTFSQ---KHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEAD 589
Query: 303 ESIKKLLEMLQSKG---LPSKS---LEDDNERTRRMAEAESQVSHLEVILDQKE-----K 351
+ EM Q +G P K LED + M ES + +E E
Sbjct: 590 HEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTS 649
Query: 352 ENIHLREE-LHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVL 410
E I L + + +S Q A+ + + ++ L+ I +LE +
Sbjct: 650 EEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEK 709
Query: 411 NTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQH 470
N +++ +EI + I++ K+ S AL + + L +Q
Sbjct: 710 NLDEKAKEISNLNQL----------IEEFKKNADNNSSAFTALSEERDQLLSQ------- 752
Query: 471 IEVLKESLTAKEQRAAILQTEVDAL------RLRLEEKESFLNKKTKQLQDLTEEKGTLA 524
+KE E RA + Q E++ RL E + + N T+Q+ L+ E +
Sbjct: 753 ---VKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKD 809
Query: 525 GEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKD-------KQLTNLKDRVKSLQTDSS 577
+I +++ L+ + + + I +LQ QL++K+ +++ ++ +V+ L S
Sbjct: 810 VKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALS 869
Query: 578 NTDTALATLEEALSEKERIIERLKEQRERDDRERL--------------EEIESFRKENK 623
+ + +++ L EK+R +E L++ E D++ EE S E K
Sbjct: 870 QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
Query: 624 DLKEKVNAL-QAELTEKESSLID------LKEHASSLASAG-------------LKRDS- 662
LKE++N L +AE +KE D LK++ ++ AG LK+++
Sbjct: 930 TLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENE 989
Query: 663 -KLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIK---QLDKEASYYRDE 718
+ + L+ A+ +KE ++ ++ N++D+S+ ++ + + DKE Y ++
Sbjct: 990 QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEK 1049
Query: 719 CGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKK 778
C ++ + + LK+ +EK E+E +R KD +K+A + Q L K+
Sbjct: 1050 CVTSKCQEIEI--YLKQTISEK--------EVELQHIR--KDLEEKLAAEEQFQALVKQM 1097
Query: 779 NAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDA---TKARLASTQQSLAEKEA 835
N L ++ + + A+ S++ I + + + D+ K + + E
Sbjct: 1098 NQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157
Query: 836 HLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKD 895
L E+ LE+ E Q+ L A++ + A+L+ + K++ +EE+ K + +
Sbjct: 1158 WKPELE-EKILALEKEKEQLQKKLQEALTSRK---AILKKAQEKERHLREELKQQKDDYN 1213
Query: 896 RLVHQLKQQTQ 906
RL Q +Q++
Sbjct: 1214 RLQEQFDEQSK 1224
Score = 90.1 bits (222), Expect = 9e-18
Identities = 154/749 (20%), Positives = 320/749 (42%), Gaps = 96/749 (12%)
Query: 228 LQDELRTQRDL--NHLLQQESGNR--GAEHFTIELTEENFRRLQAEHDRQAKELFLLRKT 283
L EL + D+ N+ Q++ R AE +EL ++ R+ + ++ + L RK
Sbjct: 30 LDPELHQESDMEFNNTTQEDVQERLAYAEQLVVEL-KDIIRQKDVQLQQKDEALQEERKA 88
Query: 284 LEEMELRIETQKQTLNARDESIKKLLEMLQSKG---LPSK--SLEDDNERTRRMAEAESQ 338
+ +I+ K A+ S+ K +E ++++G LP++ S E ++ + E E +
Sbjct: 89 ADN---KIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145
Query: 339 VSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398
+ ++ L +KE+ L+ +L + QP + T+ + V M ++ E I L+
Sbjct: 146 IEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFV--MMKQQLQEKEEFISTLQ 203
Query: 399 DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE 458
++ +A RE++ + + H + + Q E ++ + +L LQ KLE
Sbjct: 204 AQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVE-TEMQQKLRVLQRKLE 262
Query: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTE 518
Q +++L++ LTA EQR IL + L++ E+ N ++ E
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQ-------LQQMEAEHNTLRNTVETERE 315
Query: 519 EKGTLAGEIRDMKDMLEVKERKINV--LQKKIENLQEQLRDKDKQLTNLKDRVKSLQ--- 573
E L ++ LEV ERK++ LQ+++ +L EQ + L+ R +L+
Sbjct: 316 ESKILLEKME-----LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKH 370
Query: 574 -TDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEI-----------ESFRKE 621
+ + + +L++ E + + LK+Q + +++ E+ + +++
Sbjct: 371 KAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430
Query: 622 NKDLKEKVN--ALQAELTEKESSLIDL---------KEHASSLASAGLKRDSKLKSL--- 667
+K++ + +N LQ T ++S D+ +E+ +SL ++ +++ +L
Sbjct: 431 SKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLS 490
Query: 668 EIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFAD-QIKQLDKEASYYRDECG------ 720
I +E+ K E KL +Q+ + E ++ I + + S +E G
Sbjct: 491 SIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN 550
Query: 721 ---KAQAEVDRLLEILKEVENE-------KNDKDKKIAELESLTLRHMKD-QNKKVANLK 769
+ E+ LL +KE + E K + A+ E L + MK + + +A +K
Sbjct: 551 TFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIK 610
Query: 770 HNQQLE-----------KKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDA 818
LE ++ + +E+ + + + S+ + + + L+ T+Q+ D
Sbjct: 611 MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 670
Query: 819 TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSAS 878
+ + + Q ++ L + +E LE QE + EK I+ L
Sbjct: 671 SLSAVPDIGQCHQDELERLKSQILE----LELNFHKAQEIYEKNLDEKAKEISNLNQLIE 726
Query: 879 KKKKTQEE----VMALKREKDRLVHQLKQ 903
+ KK + AL E+D+L+ Q+K+
Sbjct: 727 EFKKNADNNSSAFTALSEERDQLLSQVKE 755
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 125 bits (314), Expect = 2e-28
Identities = 172/818 (21%), Positives = 372/818 (45%), Gaps = 99/818 (12%)
Query: 151 QAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQ 210
Q +K+ + E + LR LD+++ + S ++ SP K +++EEAA + E
Sbjct: 795 QQAVKDYELEAEKLRSLLDLENGR-SSHVSKRARLQSPATK----VKEEEAALAAKFTEV 849
Query: 211 MRVSHEENQHLQLTIQAL--QDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQA 268
++ + Q+L+ + L Q E+ + + +SG A EL EE RR Q
Sbjct: 850 YAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQL 909
Query: 269 EHDRQA--KELFLLRKT-LEEMELRIETQKQTLN-ARDESIKKLLEMLQSKGLPSKSLED 324
E++ ++ +E++ LR +E +R E K+ + +ES ++L L + ++ L++
Sbjct: 910 ENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQE 969
Query: 325 DNERTR---RMAEAESQVSHLEVILDQK---EKENIHLREELHRRSQLQPEPAKTKALQT 378
+ E + R E E++ E ++ + E + E L R +L+ + A +
Sbjct: 970 ELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREA 1029
Query: 379 VIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQ 438
+ + ++A+L ++++ + + N E E +Q++ + H + DQ
Sbjct: 1030 EVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQ--EDHQRQ-----DQ 1082
Query: 439 LKQELSKKESELLALQTKLETLSNQNS------DCKQHIEVLKESLTAKEQRAAILQTEV 492
L++ K+E EL LQ KL+ L + + K+ ++V K++ T +E Q E
Sbjct: 1083 LRE---KQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYED 1139
Query: 493 DALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIR-------DMKDMLEVKERKINVLQ 545
+A + R ++E + +++ L EE + + + D K EV ++ +++
Sbjct: 1140 EAAKARASQREK--TELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVE 1197
Query: 546 --KKIENLQEQLRDKDKQLTNLKDR------------VKSLQTDSSNTDTALATLEEALS 591
+K +EQLR +L L+ R V +TD + L L E +
Sbjct: 1198 QERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE-MEKELQRLREEIV 1256
Query: 592 EKERIIER--------------LKEQRER-DDRERLEEIESFRKENKDLKEKVNALQAEL 636
+K R+IER LK+ + + +E ++EI F+ E+ KE+V +L+A+L
Sbjct: 1257 DKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQ-EDPQTKEEVASLRAKL 1315
Query: 637 TEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSR 696
+E++ +DL+ +S +++ +L ++ + Q++ + E L+ + S
Sbjct: 1316 SEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLR-----AEASA 1370
Query: 697 MNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLR 756
+++Q+DK + R + + E++R LE L+ + + ++++ L+
Sbjct: 1371 FAESIDVELRQIDKLRAELR-RLQRRRTELERQLEELERERQARREAEREVQRLQQRLAA 1429
Query: 757 HMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQEL 816
+++ + + H Q++ +++ Q + RE ++ LQ+EE + + EL
Sbjct: 1430 LEQEEAEAREKVTHTQKVVLQQDPQ-----QAREHALL----RLQLEEEQHRRQLLEGEL 1480
Query: 817 DATKARLASTQQS-LAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLEL 875
+ + +LA+ +++ + EK ++++E+ +EI +K + S+++ ++ + L
Sbjct: 1481 ETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRL 1540
Query: 876 SAS------KKKKTQEEVMALKREKDRLVHQLKQQTQN 907
A K+ +E+ L+ E H+L+ + QN
Sbjct: 1541 EARLSELEFHNSKSSKELDFLREEN----HKLQLERQN 1574
Score = 100 bits (249), Expect = 6e-21
Identities = 174/801 (21%), Positives = 334/801 (41%), Gaps = 140/801 (17%)
Query: 164 LRKELDIKDSKLGSSMNSIKT----FWSPELK--KERVLRKEEAARMS--VLKE---QMR 212
+RKELD + + N +K+ W+ + +E V+RKE ++ VL+E Q++
Sbjct: 895 IRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQ 954
Query: 213 VSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDR 272
+ E QH Q LQ+EL + L+QE+ + G E+ E+ R QA+
Sbjct: 955 RTLAEEQHKN---QLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVL 1011
Query: 273 QAKE-LFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRR 331
Q +E L LR+ E + +Q + A E + E + K + L++D +
Sbjct: 1012 QLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK--LQNDPQLEAE 1069
Query: 332 MAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIE-MKDTKIASL 390
+ + + + +++E+E L+++L R L+ E A + TV E +K K A+
Sbjct: 1070 YQQLQEDHQRQDQLREKQEEELSFLQDKLKR---LEKERAMAEGKITVKEVLKVEKDAAT 1126
Query: 391 ERNIRDL----EDEIQMLKANGVLNTE------DREEEIKQIEVY-----------KSHS 429
ER + DL EDE +A+ TE EEE ++ V K+ S
Sbjct: 1127 EREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAES 1186
Query: 430 KFMKTKIDQLKQELSKK--ESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAI 487
+ +++ ++QE + E +L + Q++LE L + + EV KE + K
Sbjct: 1187 EVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVK-EVTKEVIKYKTDPE-- 1243
Query: 488 LQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAG---------------------- 525
++ E+ LR + +K + + ++ L +E L
Sbjct: 1244 MEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQ 1303
Query: 526 ---EIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTA 582
E+ ++ L +++K L+++ + +EQ+ K+++L+ +K+RV + +
Sbjct: 1304 TKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPG 1363
Query: 583 L----ATLEEALSEKERIIERLKE-----QRERDDRER-LEEIESFRKENKDLKEKVNAL 632
L + E++ + R I++L+ QR R + ER LEE+E R+ ++ + +V L
Sbjct: 1364 LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRL 1423
Query: 633 QAELTEKESSLIDLKEHASSLASAGLKRDSK------LKSLEIAIEQKKEECSKLE---- 682
Q L E + +E + L++D + L L++ EQ + + + E
Sbjct: 1424 QQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETL 1483
Query: 683 ----AQLKKAH---------------------------NIEDDSRMNPEFADQIKQLDKE 711
A L+KA ++E++SR E ++ +L+
Sbjct: 1484 RRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEAR 1543
Query: 712 ASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELES---LTLRHMKD-QNKKVAN 767
S K+ E+D L E +++ E+ + + L+S + +D +N VA+
Sbjct: 1544 LSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVAD 1603
Query: 768 LKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARL---- 823
N + L++++R + L+I+EL L + + + L
Sbjct: 1604 SGTNHDSRLWSLERELDDLKR-----LSKDKDLEIDELQKRLGSVAVKREQRENHLRRSI 1658
Query: 824 ----ASTQQSLAEKEAHLANL 840
T + L+ +EAH A L
Sbjct: 1659 VVIHPDTGRELSPEEAHRAGL 1679
Score = 89.7 bits (221), Expect = 1e-17
Identities = 126/585 (21%), Positives = 255/585 (43%), Gaps = 80/585 (13%)
Query: 133 HQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDI-------KDSKLGSSMNSIKTF 185
HQ LR+ ++ + LQ +LK L++E + ++ + KD+ ++ +
Sbjct: 1077 HQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQ 1136
Query: 186 WSPELKKERVLRKEEA---ARMSVLKEQMR--VSHEENQHLQLTIQALQDELRTQRDLNH 240
+ E K R ++E+ ++ L+E+ V E+ + + + E+ R
Sbjct: 1137 YEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR--LE 1194
Query: 241 LLQQESGNRGAEH----FTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQ 296
L++QE RGAE + EL R Q E KE+ + KT EME ++ ++
Sbjct: 1195 LVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEV-IKYKTDPEMEKELQRLRE 1253
Query: 297 TLNARDESIKKL-LEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILD-------- 347
+ + I++ LE+ Q K + + + + + QV EV+ +
Sbjct: 1254 EIVDKTRLIERCDLEIYQLK-----------KEIQALKDTKPQVQTKEVVQEILQFQEDP 1302
Query: 348 QKEKENIHLREELHRRSQLQPEPAKTKALQ-TVIEMKDTKIASLERNIRDLE----DEIQ 402
Q ++E LR +L + Q + + +A Q I K+ +++ ++ + E +E
Sbjct: 1303 QTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEP 1362
Query: 403 MLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLA---------- 452
L+A E + E++QI+ ++ + ++ + +L+++L + E E A
Sbjct: 1363 GLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQR 1422
Query: 453 LQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQ 512
LQ +L L + ++ ++ + ++ + ++ + A E LRL+LEE++
Sbjct: 1423 LQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQA---REHALLRLQLEEEQ--------- 1470
Query: 513 LQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKI--ENLQEQLRDKDKQLTNLKDRVK 570
+ L GE+ ++ L E K V +K + E++Q + D ++++ LK ++
Sbjct: 1471 -----HRRQLLEGELETLRRKLAALE-KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLE 1524
Query: 571 SLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVN 630
D ++ LE LSE E K +E D EE + E ++L+ +
Sbjct: 1525 EESRSKRELDVEVSRLEARLSELE--FHNSKSSKELDFLR--EENHKLQLERQNLQLETR 1580
Query: 631 ALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKK 675
LQ+E+ + DL+ ++A +G DS+L SLE ++ K
Sbjct: 1581 RLQSEINMAATETRDLRN--MTVADSGTNHDSRLWSLERELDDLK 1623
Score = 86.3 bits (212), Expect = 1e-16
Identities = 136/653 (20%), Positives = 278/653 (42%), Gaps = 64/653 (9%)
Query: 309 LEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHR-RSQL- 366
L + S G +S+ ++R + +V E D + + L L + S L
Sbjct: 460 LALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLD 519
Query: 367 QPEPAKTKALQTVIEMKDTKIASLER--NIRDLEDEIQMLKANGVLNTEDREEEIKQIEV 424
+ E A T L+ +E S ER +++++ +E+ ++ +T + E I+ +
Sbjct: 520 RQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
Query: 425 YKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQR 484
+ ++T+++ ++ L Q K++ + +Q E+L Q
Sbjct: 580 -SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQD 638
Query: 485 AAILQT---------EVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE 535
+ ++ E+ A+ L+ ++S L + + LQ + TLA ++ LE
Sbjct: 639 DTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLE 698
Query: 536 VKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATL-------EE 588
+E +++ L ++ NL++Q+ + + L + K + + L ++ +
Sbjct: 699 RQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETD 758
Query: 589 ALSEKERIIERLKEQRERDDR--ERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDL 646
+LS+ E +LK Q+ D R +E++ ++ ++ V + E EK SL+DL
Sbjct: 759 SLSQME---TKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELE-AEKLRSLLDL 814
Query: 647 KEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQI- 705
+ SS SK L+ + KEE + L A+ + + I N EFA +
Sbjct: 815 ENGRSS-------HVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867
Query: 706 -KQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKN-----DKDKKIAELESLTLRHMK 759
+Q + E ++ + + + V+ +I KE++ E + + K + E TLR+
Sbjct: 868 RQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQG 927
Query: 760 DQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDAT 819
Q V + L+K + L E ++ + ++A+ Q+ L LE + +L A
Sbjct: 928 PQESVV----RKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQL--LQEELEALQLQLRAL 981
Query: 820 KARLASTQQSLAEKEAHLANLRIE-RRKQLEEILEMKQ--EALLAAISEKDANIALL--- 873
+ Q KE LRIE R Q +E+L++++ EAL ++A + LL
Sbjct: 982 EQETRDGGQEYVVKEV----LRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQR 1037
Query: 874 ------ELSASKKKKTQEEVMALKREKD-RLVHQLKQQTQNRMKLMADNYDDD 919
E S +++K T++EV+ L+ + +Q Q+ R + + +++
Sbjct: 1038 VAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEE 1090
Score = 78.2 bits (191), Expect = 3e-14
Identities = 105/488 (21%), Positives = 216/488 (44%), Gaps = 61/488 (12%)
Query: 151 QAQLKELQRENDLLRK---ELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVL 207
+ QL+ Q E + LR+ ++++K+ + IK PE++KE +EE + L
Sbjct: 1206 EEQLRSYQSELEALRRRGPQVEVKEV----TKEVIKYKTDPEMEKELQRLREEIVDKTRL 1261
Query: 208 KEQMRVSHEENQHLQLTIQALQD---ELRTQRDLNHLLQQESGNRGAEHFT---IELTEE 261
E+ + E L+ IQAL+D +++T+ + +LQ + + E +L+EE
Sbjct: 1262 IERCDL---EIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEE 1318
Query: 262 NFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKS 321
+++ E +R ++E + RK E ++ +Q + +E GL
Sbjct: 1319 QKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEE----------PGL---- 1364
Query: 322 LEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIE 381
AEA + ++V L Q +K LR RR++L+ + + + +
Sbjct: 1365 ----------RAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARR 1414
Query: 382 MKDTKIASLERNIRDLEDEI-----QMLKANGVLNTEDREEEIK------QIEVYKSHSK 430
+ ++ L++ + LE E ++ V+ +D ++ + Q+E + +
Sbjct: 1415 EAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQ 1474
Query: 431 FMKTKIDQLKQELSKKESELLALQTKL-ETLSNQNSDCKQHIEVLKESLTAKEQRAAILQ 489
++ +++ L+++L+ E + + L E++ + D +Q I+ LK SL + + L
Sbjct: 1475 LLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELD 1534
Query: 490 TEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIE 549
EV L RL E E +K +K+L L EE L E ++++ + +IN+ +
Sbjct: 1535 VEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETR 1594
Query: 550 NLQEQL-----RDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQR 604
+L+ + D +L +L+ + L+ S + D + L++ L + +EQR
Sbjct: 1595 DLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGS----VAVKREQR 1650
Query: 605 ERDDRERL 612
E R +
Sbjct: 1651 ENHLRRSI 1658
Score = 73.2 bits (178), Expect = 1e-12
Identities = 123/632 (19%), Positives = 276/632 (43%), Gaps = 70/632 (11%)
Query: 291 IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEA-------ESQVSHLE 343
+ T+ + N + E + +LL++ Q K + LE +++ + + V
Sbjct: 586 LRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESS 645
Query: 344 VILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE-DEIQ 402
+LD K +E + EL + L E + LQ + T + + + DLE E +
Sbjct: 646 RVLDSKGQELAAMACELQAQKSLLGEVEQN--LQAAKQCSSTLASRFQEHCPDLERQEAE 703
Query: 403 MLKANGVLNT-----EDREEEIKQIEV-----YKSHSKFMKTKIDQLKQELSKKESELLA 452
+ K N E R + ++ + ++ H ++ + E + +S L
Sbjct: 704 VHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDS-LSQ 762
Query: 453 LQTKLETLSNQNSD-CKQHIEVLKESLTAKEQRAAILQTEVDALRLR----LEE-KESFL 506
++TKL+ N + + EV K +++ + A+ E++A +LR LE + S +
Sbjct: 763 METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHV 822
Query: 507 NKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLK 566
+K+ + T+ K A ++ + +++ L+ + L++Q + ++T+
Sbjct: 823 SKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQ---PEVEVTH-- 877
Query: 567 DRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLK 626
++LQ + ++ +EEA ++ + E + +R+ ++ + + E + N+ +
Sbjct: 878 ---ETLQRNRPDSG-----VEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQ 929
Query: 627 EKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLK 686
E V ++ E+ +K + L+E L + K + L+ +E + + LE + +
Sbjct: 930 ESV--VRKEVLKKVPDPV-LEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETR 986
Query: 687 ---KAHNIEDDSRMNPEFA--DQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKN 741
+ + +++ R+ P+ A D++ QL +E R + G +AEV L + + + EK+
Sbjct: 987 DGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKS 1046
Query: 742 DKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ 801
+K+ E K+V L+++ QLE + Q L+E +R+D + + Q +
Sbjct: 1047 RAQEKVTE-------------KEVVKLQNDPQLEAE--YQQLQEDHQRQDQLRE-KQEEE 1090
Query: 802 IEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLA 861
+ L + L++ +E + ++ + EK+A + +Q E+ EA A
Sbjct: 1091 LSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYED------EAAKA 1144
Query: 862 AISEKDANIALLELSASKKKKTQEEVMALKRE 893
S+++ L ++ A +++ + V RE
Sbjct: 1145 RASQREKTELLRKIWALEEENAKVVVQEKVRE 1176
Score = 36.2 bits (82), Expect = 0.15
Identities = 76/380 (20%), Positives = 165/380 (43%), Gaps = 46/380 (12%)
Query: 457 LETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEE------KESFLNK-- 508
++T S N + + IE L+++ E+ + ++ + RL+E ++ L K
Sbjct: 17 VQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVL 76
Query: 509 KTKQLQDLTEEKGTLAGEIR----DM--KDMLEVKERKINVLQKKIENLQEQLRDKDKQL 562
+++L + E +A ++ DM +D+ ++KER N+ K + + +++ D Q+
Sbjct: 77 DSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQV 136
Query: 563 T---NLKDRVKSLQTDSSNTDTALAT--LEEAL---SEKERIIERLKEQRERDDRERLE- 613
+++++ L S TD L +EE +E + I L + +++ L
Sbjct: 137 NWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRA 196
Query: 614 EIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSL-----ASAGLKRDSKLKSLE 668
+ + ++ ++ +++LQ + + L L + A + L S+ + E
Sbjct: 197 KYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYE 256
Query: 669 IAI----EQKKEECSKLEAQLKKAHNIEDDSR---------MNPEFADQIKQLDKEASY- 714
I E K+E +KL ++ + E R ++ ++ + + L E S+
Sbjct: 257 NFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHL 316
Query: 715 -YRDECGKAQAEVDRLLEILKEVENEKNDK---DKKIAELESLTLRHMKDQNKKVANLKH 770
Y ++ + +V E+L++V+++ N K D K L LR + DQ K + +
Sbjct: 317 KYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYED 376
Query: 771 NQQLEKKKNAQLLEEVRRRE 790
Q +K+ Q++ RRE
Sbjct: 377 VVQGLQKRGQQVVPLKYRRE 396
Score = 30.8 bits (68), Expect = 6.3
Identities = 69/342 (20%), Positives = 139/342 (40%), Gaps = 42/342 (12%)
Query: 604 RERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLK-EHASSLA--SAGLKR 660
R+R+ + +++ NK+L E + LQ + E +++D + + S LA G +
Sbjct: 6 RKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQP 65
Query: 661 DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
+ + +L+ ++ +K LEA A +++ A+ I+QL + + R +
Sbjct: 66 EHRDVTLQKVLDSEK-LLYVLEADAAIAKHMKHP--QGDMIAEDIRQLKERVTNLRGK-- 120
Query: 721 KAQAEVDRLLEILKEVENEKN------DKDKKIAELESLTLRHMKDQNKKVANLKHNQ-- 772
++ RL +KEV+ + N +K K+ T + D + N+ HN+
Sbjct: 121 --HKQIYRL--AVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVK 176
Query: 773 ----QLEKKKNAQLLEEVRRREDSMADNSQHLQ--IEELMNALEKTRQEL----DATKAR 822
L K + + E+R + + SQ Q + L + +++ EL K R
Sbjct: 177 AIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGR 236
Query: 823 LASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKK 882
+ Q +++ + R + + LE K+E + SE D +A + +
Sbjct: 237 M---QYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEA 293
Query: 883 TQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDDHHHYH 924
E V A +E L+ + + Y +D+H +H
Sbjct: 294 HMEAVHADWKEYLNLLICEESHLK---------YMEDYHQFH 326
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 124 bits (312), Expect = 3e-28
Identities = 181/830 (21%), Positives = 347/830 (41%), Gaps = 97/830 (11%)
Query: 149 DLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLK 208
+L+A+ + L ++ RKEL+ + + ++ + VLR+E L
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE-------LA 790
Query: 209 EQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQA 268
E M H + ++ E+ R+ QQE GA + +E L+
Sbjct: 791 EAMAAQHTAESECEQLVK----EVAAWRERYEDSQQEEAQYGA------MFQEQLMTLKE 840
Query: 269 EHDRQAKELFLLRKTL----EEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLED 324
E ++ +EL ++ + EL+I Q+ L ++ + L+ +Q K + ++ L D
Sbjct: 841 ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD 900
Query: 325 D-NERTRRMAEAESQVSHLEVIL----DQKEKENIHLREELHRRSQLQPEPAKTKALQTV 379
D + +MA +V+ LE ++ +Q+E + L +E R QPE + + +
Sbjct: 901 DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQF 960
Query: 380 IEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQL 439
+ + ++ER + +E++ L+A + + ++EE Q E ++ +L
Sbjct: 961 CSTQ-AALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE----------REVARL 1009
Query: 440 KQELSKKESELL---ALQTKLE-----TLSNQNSDCKQHIEVLKESLTAKE---QRAAIL 488
QE + +++L A + +LE L+ Q + E L +LT KE Q A L
Sbjct: 1010 TQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKL 1069
Query: 489 QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKI 548
+ A LEE + + +QL +E + +G + E K+ L+ ++
Sbjct: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV 1129
Query: 549 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDD 608
L++Q + + +Q +L+ +++ + + D+AL TL+ L EK + + +
Sbjct: 1130 SKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQ 1189
Query: 609 RERL---EEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLK 665
RE +++ K + K +V + E K S + L+E S L L+++ + K
Sbjct: 1190 RELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESK 1249
Query: 666 SLEIAIEQKKEECSKLEAQLK-----KAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
L+ + + E+ KLE +L+ A N + + ++++ L +EA R
Sbjct: 1250 ELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASE 1309
Query: 721 KAQAEVDRLLEILKEVENEKNDKDKKIAE----LESLTLRHMKDQ--------------- 761
+ E+ E +E+ E +K + L +L L H Q
Sbjct: 1310 NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369
Query: 762 ---NKKVANLKHNQQLEKKKNAQ--LLEEVRRREDSMADNSQHLQIEELMNALEKTRQEL 816
+ A +H ++LE+ K A L E+ R + + + + + + + E+T Q+L
Sbjct: 1370 LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL---GELIPLRQKVAEQERTAQQL 1426
Query: 817 DATKA-------RLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEAL---LAAISEK 866
A KA L LAE+ L R+ LE L+ +E LAA+
Sbjct: 1427 RAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV-RA 1485
Query: 867 DANIALLELSASKKKKTQE-EVMALKRE--KDRLVHQLKQQTQNRMKLMA 913
DA L E+ + +E EVM K E K +++ + ++ + R KL A
Sbjct: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTA 1535
Score = 122 bits (305), Expect = 2e-27
Identities = 162/778 (20%), Positives = 334/778 (42%), Gaps = 97/778 (12%)
Query: 190 LKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNR 249
L+K+ L KE +A + + + E+N+ LQ + L++ L +D QE G
Sbjct: 356 LEKQAQLEKELSAAL----QDKKCLEEKNEILQGKLSQLEEHLSQLQDNP---PQEKGEV 408
Query: 250 GAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 309
+ +E ++ L A + + + +L + E ++ ++ + + L+
Sbjct: 409 LGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLI 468
Query: 310 EMLQSKGLPSKSLEDDNER---------TRRMAEAESQVSHLEVILDQKEKENIHLREEL 360
LQS +++ E+ T ++A S+++ L + Q+++E L+++
Sbjct: 469 TDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQA 528
Query: 361 HRRSQ-----LQPEPAKTKALQTVIEMKDTKIASLERNIRDL--------EDEIQMLKAN 407
+ LQ + ++ L+ +E + + E+ ++++ +D Q L
Sbjct: 529 KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588
Query: 408 GV---LNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQN 464
+ +R+ +KQ+E + K K++ L+Q+L + QT + +
Sbjct: 589 AEEREASLRERDAALKQLEALE---KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK 645
Query: 465 SDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE-------EKESFLNKKTK---QLQ 514
++ + +E L+ + Q Q +V L L+L EKE +K + QLQ
Sbjct: 646 AELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQ 705
Query: 515 DLTEE----KGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQL-------T 563
L E KG+L E R D LE ++R I+ L+ + +L EQ + + K+L
Sbjct: 706 ALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRK 765
Query: 564 NLKDRVKSL-QTDSSNTDTALATLEEAL-------SEKERIIERLKEQRERDDRERLEEI 615
L+ R++ L + + T+ L EA+ SE E++++ + RER + + EE
Sbjct: 766 GLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEA 825
Query: 616 E---SFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIE 672
+ F+++ LKE+ + EL E + + ++ H+ E+ I
Sbjct: 826 QYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS-----------------ELQIS 868
Query: 673 QKKEECSKLEAQLKKA-HNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
+++ E ++L A L +A +++ + AD + L ++ + E + + V + E
Sbjct: 869 RQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 928
Query: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
+ E + + + + L + Q ++ + + Q +++ Q+ E+ R
Sbjct: 929 QQETASRELVKEPARAGDRQPEWLE--EQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986
Query: 792 SMADNSQHLQIEELMNALEKTR--QELDATKARLASTQQSLAEKEAHLANLRIERRKQLE 849
++ ++ Q E E R QE +A LA + + AE E L N E+R +
Sbjct: 987 ALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFA 1046
Query: 850 EILEMKQEALLAAISE---KDANIALLE-LSASKKKKTQEEVMALKREKDRLVHQLKQ 903
+ QEAL A++E KD +A L L A++ K+ +E +K+ K++L + K+
Sbjct: 1047 TL----QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100
Score = 118 bits (295), Expect = 3e-26
Identities = 150/714 (21%), Positives = 307/714 (42%), Gaps = 92/714 (12%)
Query: 237 DLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQ 296
+L + SGN + + Q + R K+L R +E+EL + ++
Sbjct: 183 ELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRK 242
Query: 297 TLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHL 356
L +D I + + + L ++ + A + + LE + D+ E + L
Sbjct: 243 LLTEKDAQIAMMQQRIDRLALLNE----------KQAASPLEPKELEELRDKNESLTMRL 292
Query: 357 REELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDRE 416
E L + L+ E ++ + I + L +R+ +Q L+ LN
Sbjct: 293 HETLKQCQDLKTEKSQ---MDRKINQLSEENGDLSFKLREFASHLQQLQ--DALN----- 342
Query: 417 EEIKQIEVYKSHSKFMKTKID---QLKQELSKKESELLALQTKLETLSNQNSDCKQHIEV 473
E+ + HSK + ++ QL++ELS + L+ K E L + S ++H+
Sbjct: 343 ------ELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396
Query: 474 LKES--------------LTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEE 519
L+++ L +Q AA L L+ R+E E+ ++ +Q L E
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLET---ERGQQEAKLLAE 453
Query: 520 KGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNT 579
+G E + + ++ + I+ L + E L++ + +LT +V SL ++
Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT---AQVASLTSE---- 506
Query: 580 DTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEK 639
L TL + ++++ + LK+Q + + + ++ + ++ L+ +V L + L +K
Sbjct: 507 ---LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQK 563
Query: 640 ESSLIDLKE--------HASSLASAGLKRDSKLKSLEIAIEQ----KKEECSKLE---AQ 684
E L ++ E HA LA+A +R++ L+ + A++Q +KE+ +KLE Q
Sbjct: 564 EQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623
Query: 685 LKKAHNIEDDS--------RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEV 736
L+ A+ D + R E + ++++L R E +AQA+V LE+
Sbjct: 624 LQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE-LELQLRS 682
Query: 737 ENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADN 796
E +K + +++A+ + ++ + + K + + EK++ A LEE +R +
Sbjct: 683 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR-----CIS 737
Query: 797 SQHLQIEELMNALEKTRQELDATKARLASTQQSLAE-KEAHLANLRIERRKQLEEI---- 851
+ L+ ++ R+EL+ +A + L + EAH A + RR+ E +
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797
Query: 852 -LEMKQEALLAAISE-KDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQ 903
E + E L+ ++ ++ + A QE++M LK E ++ +L++
Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE 851
Score = 113 bits (282), Expect = 1e-24
Identities = 167/799 (20%), Positives = 332/799 (41%), Gaps = 87/799 (10%)
Query: 166 KELDIKDSKLGSSMNSIKTFWSPELKK----ERVLRK----EEAARMSVLKEQMRVSHEE 217
+E +++ KL +++++ + K+ E ++RK +E A ++KE R +
Sbjct: 889 QEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ 948
Query: 218 NQHL-----------QLTIQALQDELRTQ-RDLNHLLQQESGNRGAEHFTIELTEENFRR 265
+ L Q +QA++ E +L L ++G + E R
Sbjct: 949 PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVAR 1008
Query: 266 LQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDD 325
L E R +L L + E+E+R++ LN + L E L + L K +D
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQN---ALNEQRVEFATLQEAL-AHALTEKEGKDQ 1064
Query: 326 NERTRRMAEAESQVSHLEVILD--QKEKENIHLREELHRR-SQLQPEPA-KTKALQTVIE 381
R EA +Q+ LE + ++ KE + +E+ H S Q E A +T+ +E
Sbjct: 1065 ELAKLRGLEA-AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLE 1123
Query: 382 MKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQ 441
+++ LE+ + +++ L+ + R E +E + + ++ +
Sbjct: 1124 ALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQS 1183
Query: 442 ELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEE 501
L+ + EL A +TK++ S + K + ++ K + L+ EV L ++ E
Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243
Query: 502 KESF-----------------LNKKTKQLQDLTEEKGTLAGE----IRDMKDMLEVKERK 540
KE L ++ + LQ T A E +R+ L + K
Sbjct: 1244 KEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303
Query: 541 INVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERL 600
V ENL+++L + ++ L +K+ Q + AL+TL+ + + ++ L
Sbjct: 1304 QRVAS---ENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360
Query: 601 KEQRERDDRERLEEIESFRKENKDL---KEKVNALQAELTEKESSLIDLKEHASSLASAG 657
+ + + E+ + ++ ++L K+ L+AEL + L +L
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGEL----------- 1409
Query: 658 LKRDSKLKSLEIAIEQKKEECSKLEAQL---KKAHNI-EDDSRMNPEFADQIKQ-----L 708
+ K+ E +Q + E + QL KKAH + +++R E A+ +Q L
Sbjct: 1410 IPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469
Query: 709 DKEASYYRDECGKAQAEVD-RLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVAN 767
D+ Y E +A+ + RL E+ +E ++ ELE +T ++ + K +
Sbjct: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTAR-------ELEVMTAKYEGAKVKVLEE 1522
Query: 768 LKHNQQLEKKKNAQLLE-EVRRREDSMADNSQHLQIEELMNALEKTRQELDATKARLAST 826
+ Q+ +K AQ+ + EV +RE + ++ + A + +Q+L A +A+ +
Sbjct: 1523 RQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGES 1582
Query: 827 QQSLAEKEAHLANLR--IERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQ 884
QQ +A L L+ + +++Q E +++ E K L+ ++ Q
Sbjct: 1583 QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQ 1642
Query: 885 EEVMALKREKDRLVHQLKQ 903
+E L+ E +RL H+L+Q
Sbjct: 1643 KENKELRAEAERLGHELQQ 1661
Score = 92.8 bits (229), Expect = 1e-18
Identities = 145/652 (22%), Positives = 280/652 (42%), Gaps = 98/652 (15%)
Query: 281 RKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVS 340
RK E + QK + E K + +L + SKS D E+ +AE V
Sbjct: 72 RKHPSSPECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDW-EQFEYKIQAELAVI 130
Query: 341 HLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDE 400
L+ +LD ++ ++L E+L Q P P+ + T E +R IR LE
Sbjct: 131 -LKFVLDHED--GLNLNEDLENFLQKAPVPSTCSS--TFPEELSPPSHQAKREIRFLE-- 183
Query: 401 IQMLKANGVLNTEDREEEIKQIEVYKSHSKFMK-TKIDQLKQELSKKESELLALQTKLET 459
++++ S + F+ + + L + ++ L+ +L
Sbjct: 184 ------------------LQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLAD 225
Query: 460 LSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEE 519
+ + + + ++ LT K+ + A++Q +D L L L EK++ + K+L++L ++
Sbjct: 226 ERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL-LNEKQAASPLEPKELEELRDK 284
Query: 520 KGTLAGEI-------RDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSL 572
+L + +D+K +RKIN L ++ +L +LR+ L L+D + L
Sbjct: 285 NESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNEL 344
Query: 573 QTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNAL 632
+ S AT E EK+ +E+ E+ + ++ K L+EK L
Sbjct: 345 TEEHSK-----ATQEWL--EKQAQLEK--------------ELSAALQDKKCLEEKNEIL 383
Query: 633 QAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIE 692
Q +L++ L+EH S L + ++ + +E K+E + L A+N +
Sbjct: 384 QGKLSQ-------LEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATL-----AANNTQ 431
Query: 693 DDSR---MNPEFADQIKQLDKEASYYRDE-------CGKAQAEVDRLLEILKEVENEKND 742
+R + E Q +L E ++ +E Q+ + L + +E+E
Sbjct: 432 LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQA 491
Query: 743 KDKKI-AELESLTLR------HMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMAD 795
++ A++ SLT ++ Q++++A LK Q K+K AQL + ++++E A
Sbjct: 492 HGARLTAQVASLTSELTTLNATIQQQDQELAGLK---QQAKEKQAQLAQTLQQQE--QAS 546
Query: 796 NSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMK 855
Q+E+L ++L++ Q+L + +T+Q A++ LA ER L E +
Sbjct: 547 QGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ---LATAAEEREASLRE-RDAA 602
Query: 856 QEALLAAISEKDANIAL----LELSASKKKKTQEEVMALKREKDRLVHQLKQ 903
+ L A EK A + + L+++ + Q V +REK L ++++
Sbjct: 603 LKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE 654
Score = 87.8 bits (216), Expect = 4e-17
Identities = 157/794 (19%), Positives = 309/794 (38%), Gaps = 141/794 (17%)
Query: 136 PSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERV 195
P L + + QA L+ ++RE + + EL+ + L S + + ++
Sbjct: 949 PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVAR 1008
Query: 196 LRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRT-QRDLNHLLQQESGN------ 248
L +E + L + E LQ + + E T Q L H L ++ G
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK 1068
Query: 249 -RGAEHFTIELTEE---NFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDES 304
RG E I+ EE ++L+ + ++ KE E R E L A
Sbjct: 1069 LRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAE 1128
Query: 305 IKKLLEMLQSKGLPSKSLEDDNERTRRM-AEAESQVSHLEVILDQKEKENIHLREELHRR 363
+ KL + Q + + SLE E R AE +S + L+ L++K +E H + L
Sbjct: 1129 VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL-AS 1187
Query: 364 SQLQPEPAKTKALQTVIEMKDTKIASLERN----------IRDLEDEIQMLKANGVLNTE 413
+Q + +TK +Q + +D A + R I LE+E+ +L VL E
Sbjct: 1188 AQRELAAFRTK-VQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQ-VLEKE 1245
Query: 414 DREEEIKQIEVYKSH--------------------------SKFMKTKIDQLKQELSKKE 447
+E+K++ + +S S ++ ++ L++E K+
Sbjct: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
Query: 448 SELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRL---------- 497
L+ +L + + + + Q ++ +E KEQ + LQ E + +
Sbjct: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
Query: 498 ---RLEEKESFLNKKTKQ-LQDLTEEKGTLAGEI----RDMKDMLEVKERKINVLQKKIE 549
+L+ +++ K+ ++ L+ + G L E+ R++ +++ +++ K+ ++ +
Sbjct: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQ-KVAEQERTAQ 1424
Query: 550 NLQEQLRDKDKQLTNLKDR---------------------------------VKSLQTDS 576
L+ + +QL+ LK V+ L
Sbjct: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVR 1484
Query: 577 SNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAEL 636
++ +T LA ++ R +E + + E + LEE + F++E + L +V L+
Sbjct: 1485 ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ 1544
Query: 637 TEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSR 696
E+ + +L + + A + KLK+++ + ++E +L+AQL
Sbjct: 1545 REQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLN---------- 1594
Query: 697 MNPEFADQIKQLDKEASYYRDECGKAQAEVD-------RLLEILKEVENEKNDKDKKIAE 749
E Q+ Q ++ A +Y+ + KA+ D L E L+ +E + + + AE
Sbjct: 1595 ---ELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAE 1651
Query: 750 LESL----------------TLRHMKDQNKKV-ANLKH-NQQLEKKKNAQLLEEVRRRED 791
E L T RH+ Q + + A + H +QQL Q+ + + +
Sbjct: 1652 AERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711
Query: 792 SMADNSQHLQIEEL 805
A L I+ L
Sbjct: 1712 PQAKPQLDLSIDSL 1725
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.327
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,399,267
Number of Sequences: 37866
Number of extensions: 1535750
Number of successful extensions: 32614
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 699
Number of HSP's successfully gapped in prelim test: 1514
Number of HSP's that attempted gapping in prelim test: 10233
Number of HSP's gapped (non-prelim): 9711
length of query: 957
length of database: 18,247,518
effective HSP length: 112
effective length of query: 845
effective length of database: 14,006,526
effective search space: 11835514470
effective search space used: 11835514470
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.