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Search of human proteins with 33636756
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
(688 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 1389 0.0
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 808 0.0
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 807 0.0
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 806 0.0
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 797 0.0
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 707 0.0
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 647 0.0
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 646 0.0
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 642 0.0
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 632 0.0
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 630 e-180
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 378 e-104
gi|193083131 MAP/microtubule affinity-regulating kinase 3 isofor... 376 e-104
gi|116256471 SNF1-like kinase [Homo sapiens] 356 3e-98
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 353 4e-97
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 295 7e-80
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 280 3e-75
gi|156105707 SNF related kinase [Homo sapiens] 272 7e-73
gi|156105705 SNF related kinase [Homo sapiens] 272 7e-73
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 268 1e-71
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 266 4e-71
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 259 8e-69
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 255 8e-68
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 254 2e-67
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 251 1e-66
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 244 2e-64
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 228 1e-59
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 187 4e-47
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 182 7e-46
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 182 7e-46
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 1389 bits (3595), Expect = 0.0
Identities = 688/688 (100%), Positives = 688/688 (100%)
Query: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR 60
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR
Sbjct: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR 60
Query: 61 LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 120
LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK
Sbjct: 61 LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 120
Query: 121 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 180
LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR
Sbjct: 121 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 180
Query: 181 DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW 240
DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW
Sbjct: 181 DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW 240
Query: 241 SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT 300
SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT
Sbjct: 241 SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT 300
Query: 301 LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV 360
LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV
Sbjct: 301 LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV 360
Query: 361 TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420
TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR
Sbjct: 361 TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420
Query: 421 RHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAH 480
RHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAH
Sbjct: 421 RHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAH 480
Query: 481 NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVP 540
NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVP
Sbjct: 481 NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVP 540
Query: 541 PASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE 600
PASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE
Sbjct: 541 PASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHE 600
Query: 601 AAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNLRE 660
AAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNLRE
Sbjct: 601 AAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNLRE 660
Query: 661 SGDLRSQVAIYLGIKRKPPPGCSDSPGV 688
SGDLRSQVAIYLGIKRKPPPGCSDSPGV
Sbjct: 661 SGDLRSQVAIYLGIKRKPPPGCSDSPGV 688
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 808 bits (2088), Expect = 0.0
Identities = 433/665 (65%), Positives = 513/665 (77%), Gaps = 26/665 (3%)
Query: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR 60
MS+RT L N+R+++ H + G GR + S +SRS GARCRNSIASC +EQPH+GNYR
Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQ--EVTSRTSRS-GARCRNSIASCADEQPHIGNYR 57
Query: 61 LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 120
LL+TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP+SLQKLFREVRIMK LNHPNIVK
Sbjct: 58 LLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 117
Query: 121 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 180
LFEVIETEKTLYL+MEYAS GEVFDYLV+HGRMKEKEAR+KFRQIVSAV YCHQK IVHR
Sbjct: 118 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 177
Query: 181 DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW 240
DLKAENLLLDA+ NIKIADFGFSNEFT+G KLDTFCGSPPYAAPELFQGKKYDGPEVD+W
Sbjct: 178 DLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 241 SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT 300
SLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L+RFLVLNP KR T
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 301 LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV 360
LEQIMKD+WIN G+E +ELKP+ EPE D D KRI++MVGMGY++EEI+ESL+ KY+E+
Sbjct: 298 LEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
Query: 361 TATYLLLGRKTEE---GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYH 417
TATYLLLGRK+ E + L+LA+VR SD N T S H K QRS S+
Sbjct: 358 TATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQS---PHHKVQRSVFSS-Q 413
Query: 418 RQRRHSDFCGPS--PAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPM 475
+QRR+SD GP+ +PKRS TST +++LKE+ + RK+S S G +G+ P+SPM
Sbjct: 414 KQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAV--GGKGIAPASPM 471
Query: 476 VSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSS- 534
+ +A NPNKA+IPER+K ST +N MTRRNTYVC+ER A+R S++ NGKENS+
Sbjct: 472 LGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTI 531
Query: 535 GTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPAS 594
R P AS S S A + +R R RG+ RSTFH GQ R+RR NGPPAS
Sbjct: 532 PDQRTPVASTHSISSA-ATPDRIRFPRGTASRSTFH-GQPRERRT------ATYNGPPAS 583
Query: 595 PTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKR---QNSNRCVSGASLPQGSK 651
P+L+HEA PL R R +TNLF+KLTSKLTRR+ + + + S+R VS + +
Sbjct: 584 PSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKE 643
Query: 652 IRSQT 656
+ ++
Sbjct: 644 AKPRS 648
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 807 bits (2084), Expect = 0.0
Identities = 429/632 (67%), Positives = 499/632 (78%), Gaps = 23/632 (3%)
Query: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR 60
MS+RT L N+R+++ H + G GR + S +SRS GARCRNSIASC +EQPH+GNYR
Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQ--EVTSRTSRS-GARCRNSIASCADEQPHIGNYR 57
Query: 61 LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 120
LL+TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP+SLQKLFREVRIMK LNHPNIVK
Sbjct: 58 LLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 117
Query: 121 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 180
LFEVIETEKTLYL+MEYAS GEVFDYLV+HGRMKEKEAR+KFRQIVSAV YCHQK IVHR
Sbjct: 118 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 177
Query: 181 DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW 240
DLKAENLLLDA+ NIKIADFGFSNEFT+G KLDTFCGSPPYAAPELFQGKKYDGPEVD+W
Sbjct: 178 DLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 241 SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT 300
SLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L+RFLVLNP KR T
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 301 LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV 360
LEQIMKD+WIN G+E +ELKP+ EPE D D KRI++MVGMGY++EEI+ESL+ KY+E+
Sbjct: 298 LEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
Query: 361 TATYLLLGRKTEE---GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYH 417
TATYLLLGRK+ E + L+LA+VR SD N T S H K QRS S+
Sbjct: 358 TATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQS---PHHKVQRSVFSS-Q 413
Query: 418 RQRRHSDFCGPS--PAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPM 475
+QRR+SD GP+ +PKRS TST +++LKE+ + RK+S S G +G+ P+SPM
Sbjct: 414 KQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAV--GGKGIAPASPM 471
Query: 476 VSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSS- 534
+ +A NPNKA+IPER+K ST +N MTRRNTYVC+ER A+R S++ NGKENS+
Sbjct: 472 LGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTI 531
Query: 535 GTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPAS 594
R P AS S S A + +R R RG+ RSTFH GQ R+RR NGPPAS
Sbjct: 532 PDQRTPVASTHSISSA-ATPDRIRFPRGTASRSTFH-GQPRERRT------ATYNGPPAS 583
Query: 595 PTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRR 626
P+L+HEA PL R R +TNLF+KLTSKLTRR
Sbjct: 584 PSLSHEATPLSQTRSRGSTNLFSKLTSKLTRR 615
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 806 bits (2081), Expect = 0.0
Identities = 434/674 (64%), Positives = 519/674 (77%), Gaps = 25/674 (3%)
Query: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR 60
MS+RT L N+R+++ H + G GR + S +SRS GARCRNSIASC +EQPH+GNYR
Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQ--EVTSRTSRS-GARCRNSIASCADEQPHIGNYR 57
Query: 61 LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 120
LL+TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP+SLQKLFREVRIMK LNHPNIVK
Sbjct: 58 LLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 117
Query: 121 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 180
LFEVIETEKTLYL+MEYAS GEVFDYLV+HGRMKEKEAR+KFRQIVSAV YCHQK IVHR
Sbjct: 118 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 177
Query: 181 DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW 240
DLKAENLLLDA+ NIKIADFGFSNEFT+G KLDTFCGSPPYAAPELFQGKKYDGPEVD+W
Sbjct: 178 DLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 241 SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT 300
SLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L+RFLVLNP KR T
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 301 LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV 360
LEQIMKD+WIN G+E +ELKP+ EPE D D KRI++MVGMGY++EEI+ESL+ KY+E+
Sbjct: 298 LEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
Query: 361 TATYLLLGRKTEE---GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYH 417
TATYLLLGRK+ E + L+LA+VR SD N T S H K QRS S+
Sbjct: 358 TATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQS---PHHKVQRSVFSS-Q 413
Query: 418 RQRRHSDFCGPS--PAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPM 475
+QRR+SD GP+ +PKRS TST +++LKE+ + RK+S S G +G+ P+SPM
Sbjct: 414 KQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAV--GGKGIAPASPM 471
Query: 476 VSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSS- 534
+ +A NPNKA+IPER+K ST +N MTRRNTYVC+ER A+R S++ NGKENS+
Sbjct: 472 LGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTI 531
Query: 535 GTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPAS 594
R P AS S S A + +R R RG+ RSTFH GQ R+RR NGPPAS
Sbjct: 532 PDQRTPVASTHSISSA-ATPDRIRFPRGTASRSTFH-GQPRERRT------ATYNGPPAS 583
Query: 595 PTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRS 654
P+L+HEA PL R R +TNLF+KLTSKLTR + +++++ N+ SL +++
Sbjct: 584 PSLSHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVS-AEQKDENKEAKPRSLRFTWSMKT 642
Query: 655 QTNLRESGDLRSQV 668
T+ + GD+ ++
Sbjct: 643 -TSSMDPGDMMREI 655
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 797 bits (2058), Expect = 0.0
Identities = 431/671 (64%), Positives = 513/671 (76%), Gaps = 35/671 (5%)
Query: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR 60
MS+RT L N+R+++ H + G GR + S +SRS GARCRNSIASC +EQPH+GNYR
Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQ--EVTSRTSRS-GARCRNSIASCADEQPHIGNYR 57
Query: 61 LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 120
LL+TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP+SLQKLFREVRIMK LNHPNIVK
Sbjct: 58 LLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 117
Query: 121 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 180
LFEVIETEKTLYL+MEYAS GEVFDYLV+HGRMKEKEAR+KFRQIVSAV YCHQK IVHR
Sbjct: 118 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 177
Query: 181 DLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW 240
DLKAENLLLDA+ NIKIADFGFSNEFT+G KLDTFCGSPPYAAPELFQGKKYDGPEVD+W
Sbjct: 178 DLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 241 SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT 300
SLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L+RFLVLNP KR T
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 301 LEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEV 360
LEQIMKD+WIN G+E +ELKP+ EPE D D KRI++MVGMGY++EEI+ESL+ KY+E+
Sbjct: 298 LEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 357
Query: 361 TATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420
TATYLLLGRK+ E VR SD N T S H K QRS S+ +QR
Sbjct: 358 TATYLLLGRKSSE-------------VRPSSDLNNSTGQS---PHHKVQRSVFSS-QKQR 400
Query: 421 RHSDFCGPS--PAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSS 478
R+SD GP+ +PKRS TST +++LKE+ + RK+S S G +G+ P+SPM+ +
Sbjct: 401 RYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAV--GGKGIAPASPMLGN 458
Query: 479 AHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSS-GTP 537
A NPNKA+IPER+K ST +N MTRRNTYVC+ER A+R S++ NGKENS+
Sbjct: 459 ASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQ 518
Query: 538 RVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTL 597
R P AS S S A + +R R RG+ RSTFH GQ R+RR NGPPASP+L
Sbjct: 519 RTPVASTHSISSA-ATPDRIRFPRGTASRSTFH-GQPRERRT------ATYNGPPASPSL 570
Query: 598 AHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTN 657
+HEA PL R R +TNLF+KLTSKLTR + +++++ N+ SL +++ T+
Sbjct: 571 SHEATPLSQTRSRGSTNLFSKLTSKLTRSRNVS-AEQKDENKEAKPRSLRFTWSMKT-TS 628
Query: 658 LRESGDLRSQV 668
+ GD+ ++
Sbjct: 629 SMDPGDMMREI 639
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 707 bits (1826), Expect = 0.0
Identities = 407/723 (56%), Positives = 485/723 (67%), Gaps = 90/723 (12%)
Query: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSS-RSLGARCRNSIASCPEEQPHVGNY 59
MS+RT L N+R+++ H ++ P+ SS R RCRNSI S +EQPH+GNY
Sbjct: 1 MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY 60
Query: 60 RLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIV 119
RL +TIGKGNFAKVKLARH+LTGREVA+KIIDKTQLNP+SLQKLFREVRIMK LNHPNIV
Sbjct: 61 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 120
Query: 120 KLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVH 179
KLFEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVH
Sbjct: 121 KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH 180
Query: 180 RDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDI 239
RDLKAENLLLD + NIKIADFGFSNEFT+G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+
Sbjct: 181 RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV 240
Query: 240 WSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRC 299
WSLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++ LVLNP KR
Sbjct: 241 WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG 300
Query: 300 TLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNE 359
+LEQIMKD+W+N+G+E EELKPYTEP+ DF DTKRI++MV MG+ R+EI ++L +QKY+E
Sbjct: 301 SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE 360
Query: 360 VTATYLLLGRKTE--EGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYH 417
V ATY+LLGRK EGG+ + G R R SD N T S +H K QRS S+
Sbjct: 361 VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQS--PAHLKVQRSISAN-Q 417
Query: 418 RQRRHSDFCGPS--PAPLHPKRSPTSTGEAELKEE--RLPGRKASCSTAGSGSRGLPPSS 473
+QRR SD GPS PA + KR ++ E+E KEE + RK +T GS S +S
Sbjct: 418 KQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSE--MTAS 475
Query: 474 PMVSSAHNPNKAEIPERRKDSTSTPNNL-PPSMMTRRNTYVCTERPGAERPSLLPNGKEN 532
P+V PER+K ST NN+ M RRNTYVC +R L NGK++
Sbjct: 476 PLVG----------PERKKSSTIPSNNVYSGGSMARRNTYVCERT--TDRYVALQNGKDS 523
Query: 533 S---------------------------------SGTP---------------------R 538
S SG P R
Sbjct: 524 SLTEMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQR 583
Query: 539 VPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLA 598
VP ASPS+HS++ + +R+R RGS+ RSTFHG Q+R+RR+ NGPPASP +
Sbjct: 584 VPAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRS------VAYNGPPASP--S 635
Query: 599 HEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRSQTNL 658
HE R +T + +K+TSK RR DPS+ + S R + S K R +
Sbjct: 636 HETGAFAHARRGTSTGIISKITSKFVRR---DPSEGEASGRTDTSRSTSGEPKERDKEEG 692
Query: 659 RES 661
++S
Sbjct: 693 KDS 695
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 647 bits (1670), Expect = 0.0
Identities = 383/643 (59%), Positives = 450/643 (69%), Gaps = 57/643 (8%)
Query: 2 SSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL 61
S+RT L N+R+++ TLG D PS S+S R RNS S +EQPH+GNYRL
Sbjct: 3 SARTPLPTLNERDTE-QPTLGH---LDSKPS--SKSNMIRGRNSATSA-DEQPHIGNYRL 55
Query: 62 LRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 121
L+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSLQKLFREVRIMK LNHPNIVKL
Sbjct: 56 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181
FEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVHRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 182 LKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241
LKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+WS
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
Query: 242 LGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTL 301
LGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++FL+LNP+KR TL
Sbjct: 236 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTL 295
Query: 302 EQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVT 361
EQIMKD+W+N+G+E +ELKPY EP D+ D +R E+MV MGYTREEI++SL Q+YNEV
Sbjct: 296 EQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVM 355
Query: 362 ATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420
ATYLLLG K+ E GD + R +D TN SS+ SH K QRS S+ +QR
Sbjct: 356 ATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SSAPSPSH-KVQRSVSAN-PKQR 406
Query: 421 RHSDFCGPSPAPLHPKRSPTSTGEAELK---EERLPGRKASCSTAGSGSRGLPPSSPMVS 477
R SD GP+ + T + AE K E+R GRKAS S P+SP+
Sbjct: 407 RFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-------STAKVPASPLPG 459
Query: 478 SAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSL----LPNGKENS 533
ER+K + + N S T R+ P ER SL + NGK+ S
Sbjct: 460 L----------ERKKTTPTPSTNSVLSTSTNRS----RNSPLLERASLGQASIQNGKD-S 504
Query: 534 SGTPRVPPASPSSHSLAPPSG--ERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGP 591
+ RVP ASPS+H+++ G +R+ RG + RSTFH GQ+R R GV
Sbjct: 505 TAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV---T 561
Query: 592 PASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKR 634
PASP+ H GR + ++F+K TSK RR +P +
Sbjct: 562 PASPS-GHS-----QGRRGASGSIFSKFTSKFVRRNLNEPESK 598
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 646 bits (1666), Expect = 0.0
Identities = 382/635 (60%), Positives = 447/635 (70%), Gaps = 57/635 (8%)
Query: 2 SSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL 61
S+RT L N+R+++ TLG D PS S+S R RNS S +EQPH+GNYRL
Sbjct: 3 SARTPLPTLNERDTE-QPTLGH---LDSKPS--SKSNMIRGRNSATSA-DEQPHIGNYRL 55
Query: 62 LRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 121
L+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSLQKLFREVRIMK LNHPNIVKL
Sbjct: 56 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181
FEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVHRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 182 LKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241
LKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+WS
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
Query: 242 LGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTL 301
LGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++FL+LNP+KR TL
Sbjct: 236 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTL 295
Query: 302 EQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVT 361
EQIMKD+W+N+G+E +ELKPY EP D+ D +R E+MV MGYTREEI++SL Q+YNEV
Sbjct: 296 EQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVM 355
Query: 362 ATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420
ATYLLLG K+ E GD + R +D TN SS+ SH K QRS S+ +QR
Sbjct: 356 ATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SSAPSPSH-KVQRSVSAN-PKQR 406
Query: 421 RHSDFCGPSPAPLHPKRSPTSTGEAELK---EERLPGRKASCSTAGSGSRGLPPSSPMVS 477
R SD GP+ + T + AE K E+R GRKAS S P+SP+
Sbjct: 407 RFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-------STAKVPASPLPG 459
Query: 478 SAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSL----LPNGKENS 533
ER+K + + N S T R+ P ER SL + NGK+ S
Sbjct: 460 L----------ERKKTTPTPSTNSVLSTSTNRS----RNSPLLERASLGQASIQNGKD-S 504
Query: 534 SGTPRVPPASPSSHSLAPPSG--ERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGP 591
+ RVP ASPS+H+++ G +R+ RG + RSTFH GQ+R R GV
Sbjct: 505 TAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV---T 561
Query: 592 PASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRR 626
PASP+ H GR + ++F+K TSK RR
Sbjct: 562 PASPS-GHS-----QGRRGASGSIFSKFTSKFVRR 590
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 642 bits (1655), Expect = 0.0
Identities = 382/636 (60%), Positives = 447/636 (70%), Gaps = 58/636 (9%)
Query: 2 SSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL 61
S+RT L N+R+++ TLG D PS S+S R RNS S +EQPH+GNYRL
Sbjct: 3 SARTPLPTLNERDTE-QPTLGH---LDSKPS--SKSNMIRGRNSATSA-DEQPHIGNYRL 55
Query: 62 LRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 121
L+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSLQKLFREVRIMK LNHPNIVKL
Sbjct: 56 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181
FEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVHRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 182 LKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241
LKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+WS
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
Query: 242 LGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTL 301
LGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++FL+LNP+KR TL
Sbjct: 236 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTL 295
Query: 302 EQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVT 361
EQIMKD+W+N+G+E +ELKPY EP D+ D +R E+MV MGYTREEI++SL Q+YNEV
Sbjct: 296 EQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVM 355
Query: 362 ATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420
ATYLLLG K+ E GD + R +D TN SS+ SH K QRS S+ +QR
Sbjct: 356 ATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SSAPSPSH-KVQRSVSAN-PKQR 406
Query: 421 RHSD-FCGPSPAPLHPKRSPTSTGEAELK---EERLPGRKASCSTAGSGSRGLPPSSPMV 476
R SD GP+ + T + AE K E+R GRKAS S P+SP+
Sbjct: 407 RFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-------STAKVPASPLP 459
Query: 477 SSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSL----LPNGKEN 532
ER+K + + N S T R+ P ER SL + NGK+
Sbjct: 460 GL----------ERKKTTPTPSTNSVLSTSTNRS----RNSPLLERASLGQASIQNGKD- 504
Query: 533 SSGTPRVPPASPSSHSLAPPSG--ERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNG 590
S+ RVP ASPS+H+++ G +R+ RG + RSTFH GQ+R R GV
Sbjct: 505 STAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV--- 561
Query: 591 PPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRR 626
PASP+ H GR + ++F+K TSK RR
Sbjct: 562 TPASPS-GHS-----QGRRGASGSIFSKFTSKFVRR 591
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 632 bits (1629), Expect = 0.0
Identities = 387/683 (56%), Positives = 455/683 (66%), Gaps = 74/683 (10%)
Query: 2 SSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL 61
S+RT L N+R+++ TLG D PS S+S R RNS S +EQPH+GNYRL
Sbjct: 3 SARTPLPTLNERDTE-QPTLGH---LDSKPS--SKSNMIRGRNSATSA-DEQPHIGNYRL 55
Query: 62 LRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 121
L+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSLQKLFREVRIMK LNHPNIVKL
Sbjct: 56 LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181
FEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARAKFRQIVSAV YCHQK IVHRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 182 LKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWS 241
LKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPPYAAPELFQGKKYDGPEVD+WS
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 235
Query: 242 LGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTL 301
LGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMSTDCE++L++FL+LNP+KR TL
Sbjct: 236 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTL 295
Query: 302 EQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVT 361
EQIMKD+W+N+G+E +ELKPY EP D+ D +R E+MV MGYTREEI++SL Q+YNEV
Sbjct: 296 EQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVM 355
Query: 362 ATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQR 420
ATYLLLG K+ E GD + R +D TN SS+ SH K QRS S+ +QR
Sbjct: 356 ATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SSAPSPSH-KVQRSVSAN-PKQR 406
Query: 421 RHSD-FCGPSPAPLHPKRSPTSTGEAELK---EERLPGRKASCSTAGSGSRGLP------ 470
R SD GP+ + T + AE K E+R GRKAS STA + LP
Sbjct: 407 RFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKAS-STAKVPASPLPGLERKK 465
Query: 471 ----PSSPMVSSAHNPNKAEIP------------ERRKDSTSTPNNLPPSMMTRRNTYVC 514
PS+ V S P + KDS + P + + + V
Sbjct: 466 TTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGS--RASTASASAAVS 523
Query: 515 TERPGAERPSL-----------LPNGKEN------SSGTPRVPPASPSSHSLAPPSG--E 555
RP + S+ LP + N S+ RVP ASPS+H+++ G +
Sbjct: 524 AARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPD 583
Query: 556 RSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNL 615
R+ RG + RSTFH GQ+R R GV PASP+ H GR + ++
Sbjct: 584 RTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV---TPASPS-GHS-----QGRRGASGSI 634
Query: 616 FTKLTSKLTRRVTLDPSKRQNSN 638
F+K TSK RR R+N N
Sbjct: 635 FSKFTSKFVRRNLSFRFARRNLN 657
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 630 bits (1625), Expect = e-180
Identities = 371/639 (58%), Positives = 434/639 (67%), Gaps = 67/639 (10%)
Query: 41 RCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL 100
R RNS S +EQPH+GNYRLL+TIGKGNFAKVKLARHILTG+EVA+KIIDKTQLN SSL
Sbjct: 3 RGRNSATSA-DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL 61
Query: 101 QKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARA 160
QKLFREVRIMK LNHPNIVKLFEVIETEKTLYLVMEYAS GEVFDYLV+HGRMKEKEARA
Sbjct: 62 QKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARA 121
Query: 161 KFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPP 220
KFRQIVSAV YCHQK IVHRDLKAENLLLDA+ NIKIADFGFSNEFT G+KLDTFCGSPP
Sbjct: 122 KFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181
Query: 221 YAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMS 280
YAAPELFQGKKYDGPEVD+WSLGVILYTLVSGSLPFDG NLKELRERVLRGKYR+PFYMS
Sbjct: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241
Query: 281 TDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVG 340
TDCE++L++FL+LNP+KR TLEQIMKD+W+N+G+E +ELKPY EP D+ D +R E+MV
Sbjct: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVS 301
Query: 341 MGYTREEIKESLTSQKYNEVTATYLLLGRKTEE-GGDRGAPGLALARVRAPSDTTNGTSS 399
MGYTREEI++SL Q+YNEV ATYLLLG K+ E GD + R +D TN SS
Sbjct: 302 MGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGD-----TITLKPRPSADLTN--SS 354
Query: 400 SKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELK---EERLPGRK 456
+ SH K QRS S+ +QRR SD GP+ + T + AE K E+R GRK
Sbjct: 355 APSPSH-KVQRSVSAN-PKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRK 412
Query: 457 ASCSTAGSGSRGLP----------PSSPMVSSAHNPNKAEIP------------ERRKDS 494
AS STA + LP PS+ V S P + KDS
Sbjct: 413 AS-STAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDS 471
Query: 495 TSTPNNLPPSMMTRRNTYVCTERPGAERPSL-----------LPNGKEN------SSGTP 537
+ P + + + V RP + S+ LP + N S+
Sbjct: 472 LTMPGS--RASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQ 529
Query: 538 RVPPASPSSHSLAPPSG--ERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASP 595
RVP ASPS+H+++ G +R+ RG + RSTFH GQ+R R GV PASP
Sbjct: 530 RVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGV---TPASP 586
Query: 596 TLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVTLDPSKR 634
+ H GR + ++F+K TSK RR +P +
Sbjct: 587 S-GHS-----QGRRGASGSIFSKFTSKFVRRNLNEPESK 619
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 378 bits (970), Expect = e-104
Identities = 191/322 (59%), Positives = 245/322 (76%), Gaps = 12/322 (3%)
Query: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 115
+G Y + RTIGKGNFA VK A H++T +VAIKIIDKTQL+ +L+K+FREV+IMK L H
Sbjct: 5 IGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCH 64
Query: 116 PNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175
P+I++L++V+ETE+ +YLV EYAS GE+FD+LV+HGRM EKEAR KF+QIV+AV++CH +
Sbjct: 65 PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR 124
Query: 176 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
NIVHRDLKAENLLLDA NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP
Sbjct: 125 NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 184
Query: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295
+VDIWSLGV+LY LV G+LPFDG L+ LR RVL GK+R+PF+MST+CE ++R LVL+P
Sbjct: 185 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDP 244
Query: 296 AKRCTLEQIMKDKWINIG----------YEGEELKPYTEPEEDFGDTKRIEVMVGMGYTR 345
KR ++EQI K KW+ +G E ++LK E + D + + M MG +
Sbjct: 245 NKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLK--EERQVDPLNEDVLLAMEDMGLDK 302
Query: 346 EEIKESLTSQKYNEVTATYLLL 367
E+ +SL S Y+ +A Y LL
Sbjct: 303 EQTLQSLRSDAYDHYSAIYSLL 324
>gi|193083131 MAP/microtubule affinity-regulating kinase 3 isoform e
[Homo sapiens]
Length = 659
Score = 376 bits (965), Expect = e-104
Identities = 210/373 (56%), Positives = 263/373 (70%), Gaps = 20/373 (5%)
Query: 260 NLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEEL 319
+LKELRERVLRGKYR+PFYMSTDCE++L+RFLVLNP KR TLEQIMKD+WIN G+E +EL
Sbjct: 178 DLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDEL 237
Query: 320 KPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEE---GGD 376
KP+ EPE D D KRI++MVGMGY++EEI+ESL+ KY+E+TATYLLLGRK+ E
Sbjct: 238 KPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDS 297
Query: 377 RGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPS--PAPLH 434
+ L+LA+VR SD N T S H K QRS S+ +QRR+SD GP+ +
Sbjct: 298 SSSSNLSLAKVRPSSDLNNSTGQS---PHHKVQRSVFSS-QKQRRYSDHAGPAIPSVVAY 353
Query: 435 PKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDS 494
PKRS TST +++LKE+ + RK+S S G +G+ P+SPM+ +A NPNKA+IPER+K S
Sbjct: 354 PKRSQTSTADSDLKEDGISSRKSSGSAV--GGKGIAPASPMLGNASNPNKADIPERKKSS 411
Query: 495 TSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSS-GTPRVPPASPSSHSLAPPS 553
T +N MTRRNTYVC+ER A+R S++ NGKENS+ R P AS S S A +
Sbjct: 412 TVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSA-AT 470
Query: 554 GERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTT 613
+R R RG+ RSTFH GQ R+RR NGPPASP+L+HEA PL R R +T
Sbjct: 471 PDRIRFPRGTASRSTFH-GQPRERRT------ATYNGPPASPSLSHEATPLSQTRSRGST 523
Query: 614 NLFTKLTSKLTRR 626
NLF+KLTSKLTRR
Sbjct: 524 NLFSKLTSKLTRR 536
Score = 297 bits (760), Expect = 3e-80
Identities = 225/583 (38%), Positives = 299/583 (51%), Gaps = 79/583 (13%)
Query: 1 MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYR 60
MS+RT L N+R+++ H + G GR + S +SRS GARCRNSIASC +EQPH+GNYR
Sbjct: 1 MSTRTPLPTVNERDTENHTSHGDGRQ--EVTSRTSRS-GARCRNSIASCADEQPHIGNYR 57
Query: 61 LLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 120
LL+TIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP+SLQKLFREVRIMK LNHPNIVK
Sbjct: 58 LLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 117
Query: 121 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 180
LFEVIETEKTLYL+MEYAS GEVFDYLV+HGRMKEKEAR+KFRQIVSAV YCHQK IVHR
Sbjct: 118 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 177
Query: 181 DLK--AENLL---------LDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG 229
DLK E +L + + + F N G+ A E +
Sbjct: 178 DLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDEL 237
Query: 230 KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRR 289
K + PE+DI I ++ G G++ +E++E + + KY + I
Sbjct: 238 KPFVEPELDISDQKRI--DIMVGM----GYSQEEIQESLSKMKY----------DEITAT 281
Query: 290 FLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIK 349
+L+L R + E D + +++P ++ G + +V +
Sbjct: 282 YLLLG---RKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQ----------R 328
Query: 350 ESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQ 409
+SQK R+ + P + R+ + T + G S K
Sbjct: 329 SVFSSQKQ-----------RRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSS 377
Query: 410 RSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTST-GEAELKEERLPGRKASCSTAGSGSRG 468
S+ G AP P S +A++ E + S +TA G
Sbjct: 378 GSAVG------------GKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGM-- 423
Query: 469 LPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCT------ERPGAER 522
++ + S ++ + + K++++ P+ P T + T R A R
Sbjct: 424 TRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASR 483
Query: 523 PSLLPNGKENSSGTPRVPPASPS-SHSLAPPSGERSRLARGST 564
+ +E + T PPASPS SH P S RS RGST
Sbjct: 484 STFHGQPRERRTATYNGPPASPSLSHEATPLSQTRS---RGST 523
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 356 bits (914), Expect = 3e-98
Identities = 176/325 (54%), Positives = 235/325 (72%), Gaps = 8/325 (2%)
Query: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 115
VG Y + RT+GKGNFA VKLARH +T +VAIKIIDKT+L+ S+L+K++REV++MK LNH
Sbjct: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH 83
Query: 116 PNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175
P+I+KL++V+ET+ LY+V E+A GE+FDYL S+G + E EAR KF QI+SAV YCH
Sbjct: 84 PHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDH 143
Query: 176 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
+IVHRDLK ENLLLD +IK+ADFGF N + G L T+CGSPPYAAPE+F+GK+Y+GP
Sbjct: 144 HIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
Query: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295
++DIWSLGV+LY LV GSLPFDG NL LR+RVL G++R+PF+MS DCES++RR LV++P
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDP 263
Query: 296 AKRCTLEQIMKDKWINI-------GYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEI 348
A+R T+ QI + +W+ YT D+ D + + +M +G R+
Sbjct: 264 ARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDY-DEQALGIMQTLGVDRQRT 322
Query: 349 KESLTSQKYNEVTATYLLLGRKTEE 373
ESL + YN A Y LL + +E
Sbjct: 323 VESLQNSSYNHFAAIYYLLLERLKE 347
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 353 bits (905), Expect = 4e-97
Identities = 176/319 (55%), Positives = 234/319 (73%), Gaps = 9/319 (2%)
Query: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 115
VG Y + T+GKGNFA VKL RH +T EVAIKIIDK+QL+ +L+K++REV+IMK L+H
Sbjct: 17 VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH 76
Query: 116 PNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175
P+I+KL++V+ET+ LYLV EYA GE+FDYL +HGR+ E EAR KF QI+SAV YCH +
Sbjct: 77 PHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
Query: 176 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
IVHRDLKAENLLLD NIKIADFGF N F G L T+CGSPPYAAPE+F+G++Y+GP
Sbjct: 137 KIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGP 196
Query: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295
++DIWS+GV+LY LV G+LPFDG L LR+RVL G++R+P++MS DCE ++RR LVL+P
Sbjct: 197 QLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDP 256
Query: 296 AKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGD-------TKRIEVMVGMGYTREEI 348
+KR T+ QI + KW+ I E +P P+E + + + +M +G +++
Sbjct: 257 SKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKT 314
Query: 349 KESLTSQKYNEVTATYLLL 367
ESL ++ YN A Y LL
Sbjct: 315 IESLQNKSYNHFAAIYFLL 333
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 295 bits (756), Expect = 7e-80
Identities = 205/566 (36%), Positives = 286/566 (50%), Gaps = 76/566 (13%)
Query: 50 PEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRI 109
P+ +VG YRL +T+GKG VKL H +TG++VAIKI+++ +L+ S L K+ RE+ I
Sbjct: 25 PQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAI 84
Query: 110 MKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 169
+K + HP+++KL +V E +K LYLV+E+ S GE+FDYLV GR+ KEAR FRQIVSA+
Sbjct: 85 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSAL 144
Query: 170 HYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG 229
+CH +I HRDLK ENLLLD + NI+IADFG ++ S L+T CGSP YA PE+ +G
Sbjct: 145 DFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKG 204
Query: 230 KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRR 289
+KYDG D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC+S+LR
Sbjct: 205 EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 264
Query: 290 FLVLNPAKRCTLEQIMKDKWINIGYE----------GEELKPYTEPEEDFGDTKRIEVMV 339
+ + P KR +LEQI K W G G + + P D +E M
Sbjct: 265 MIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMA 324
Query: 340 GMG--YTREEIKESLTSQKYN-EVTATYLLLGRK-------TEEGGDRGAPGLALARVRA 389
+G RE + L S++ N E YLLL RK ++ R RV +
Sbjct: 325 SLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDS 384
Query: 390 PSDTTNG--------------TSSSKGTSHSKGQRSSSSTYHRQRRHS---DFCGPSPAP 432
P + +G T + G S +R+ H QR S G S +P
Sbjct: 385 PMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSP 444
Query: 433 LHPKRSPTST--------------GEAELKEERLPGRKASCSTAGS-----GSRGL---- 469
L RSP + G K + LP R AG +R
Sbjct: 445 LSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPG 504
Query: 470 PPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPP--------------SMMTRRNTYVCT 515
PP SP SS P + + R T TP PP + + RN+++ +
Sbjct: 505 PPGSPR-SSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGS 563
Query: 516 ERPGAERPSLLPNGKENSSGTPRVPP 541
R R +P +E SS TP P
Sbjct: 564 PR-FHRRKMQVPTAEEMSSLTPESSP 588
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 280 bits (716), Expect = 3e-75
Identities = 176/470 (37%), Positives = 256/470 (54%), Gaps = 38/470 (8%)
Query: 55 HVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLN 114
+VG YRL +T+GKG VKL H +T ++VAIKI+++ +L+ S L K+ RE+ I+K +
Sbjct: 15 YVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 74
Query: 115 HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 174
HP+++KL +V E +K LYLV+E+ S GE+FDYLV GR+ KEAR FRQI+SA+ +CH
Sbjct: 75 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134
Query: 175 KNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 234
+I HRDLK ENLLLD + NI+IADFG ++ S L+T CGSP YA PE+ +G+KYDG
Sbjct: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194
Query: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 294
+ D+WS GVIL+ L+ G+LPFD NL++L E+V RG + +P ++ DC+S+LR + ++
Sbjct: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254
Query: 295 PAKRCTLEQIMKDKWINIGYEGEELKPYTE------------PEEDFGDTKRIEVMVGMG 342
A+R TLE I K W Y G + +P E P + D ++ M +G
Sbjct: 255 AARRLTLEHIQKHIW----YIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLG 310
Query: 343 YTREE---IKESLTSQKYNEVTATYLLLGRK----TEEGGDRGAPGLALARVRAPSDTTN 395
R+ +++ L+ ++ E +LLL RK ++E D P + R D+
Sbjct: 311 CFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDL-PPRNEIDPPRKRVDSPM 369
Query: 396 GTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGR 455
K K S T G SP P G+ + + G
Sbjct: 370 LNRHGKRRPERKSMEVLSVT----------DGGSPVPARRAIEMAQHGQ---RSRSISGA 416
Query: 456 KASCSTAG-SGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPS 504
+ ST+ S R P SP S P + ++ TPN PPS
Sbjct: 417 SSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPS 466
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 272 bits (696), Expect = 7e-73
Identities = 206/650 (31%), Positives = 311/650 (47%), Gaps = 64/650 (9%)
Query: 57 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 116
G Y L +T+G+G+FA VKLARH+ TG +VA+K+IDKT+L+ + LF+EVR MK + HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 117 NIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR-MKEKEARAKFRQIVSAVHYCHQK 175
NIV+L+EVI+T+ LYL++E G++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 176 NIVHRDLKAENLLL-DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 234
++VHRDLK EN++ + + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 294
P VDIWSLGVIL+ LV G PF N E ++ KY VP ++S +C+ ++ R L +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 295 PAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIE-------VMVGMGYTREE 347
P +R +LE+I W+ G + Y P + + E +++G R+
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
Query: 348 IKESLTSQKYNEVTATYLLLG------RKTEEGGDRGA-PGLALARVRAP---------- 390
I E+L + +YN +TATY LL ++ +E R A P A+ R
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
Query: 391 -SDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHS-----------DFCGPSPAPLHPKR- 437
D T S T R++ S + R + GP+ + + P
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
Query: 438 SPTSTG-------EAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPER 490
PT++G E + +E+ + S ST R ++ + S P +I E
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492
Query: 491 RK--DSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHS 548
+ D NLPP + + PG K G+ + SS +
Sbjct: 493 GESDDEFDMDENLPPKLSRLKMNIAS---PGTVHKRY-HRRKSQGRGS-----SCSSSET 543
Query: 549 LAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAP----L 604
S R RL + S ++H + G G GG Q+ P + +A+P
Sbjct: 544 SDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNA 603
Query: 605 PAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRS 654
G P + TS TRR + Q ++R S L + K+ S
Sbjct: 604 GGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASR--SAGELVESLKLMS 651
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 272 bits (696), Expect = 7e-73
Identities = 206/650 (31%), Positives = 311/650 (47%), Gaps = 64/650 (9%)
Query: 57 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 116
G Y L +T+G+G+FA VKLARH+ TG +VA+K+IDKT+L+ + LF+EVR MK + HP
Sbjct: 14 GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73
Query: 117 NIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR-MKEKEARAKFRQIVSAVHYCHQK 175
NIV+L+EVI+T+ LYL++E G++FDY++ H + E A+ F QIV A+ YCH+
Sbjct: 74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 176 NIVHRDLKAENLLL-DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 234
++VHRDLK EN++ + + +K+ DFGFSN+F G KL T CGS Y+APE+ G +YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 193
Query: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 294
P VDIWSLGVIL+ LV G PF N E ++ KY VP ++S +C+ ++ R L +
Sbjct: 194 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 253
Query: 295 PAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIE-------VMVGMGYTREE 347
P +R +LE+I W+ G + Y P + + E +++G R+
Sbjct: 254 PKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDA 312
Query: 348 IKESLTSQKYNEVTATYLLLG------RKTEEGGDRGA-PGLALARVRAP---------- 390
I E+L + +YN +TATY LL ++ +E R A P A+ R
Sbjct: 313 IVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQD 372
Query: 391 -SDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHS-----------DFCGPSPAPLHPKR- 437
D T S T R++ S + R + GP+ + + P
Sbjct: 373 LEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL 432
Query: 438 SPTSTG-------EAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPER 490
PT++G E + +E+ + S ST R ++ + S P +I E
Sbjct: 433 KPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEE 492
Query: 491 RK--DSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHS 548
+ D NLPP + + PG K G+ + SS +
Sbjct: 493 GESDDEFDMDENLPPKLSRLKMNIAS---PGTVHKRY-HRRKSQGRGS-----SCSSSET 543
Query: 549 LAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAP----L 604
S R RL + S ++H + G G GG Q+ P + +A+P
Sbjct: 544 SDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNA 603
Query: 605 PAGRPRPTTNLFTKLTSKLTRRVTLDPSKRQNSNRCVSGASLPQGSKIRS 654
G P + TS TRR + Q ++R S L + K+ S
Sbjct: 604 GGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASR--SAGELVESLKLMS 651
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 268 bits (685), Expect = 1e-71
Identities = 138/268 (51%), Positives = 179/268 (66%), Gaps = 6/268 (2%)
Query: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVRIMKGLNHPN 117
Y L T+GKG + KVK AR +GR VAIK I K ++ + L + RE+ IM LNHP+
Sbjct: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 118 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNI 177
I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAVHYCHQ +
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171
Query: 178 VHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEV 237
VHRDLK EN+LLDA NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 238 DIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAK 297
D WSLGV+LY LV G++PFDGH+ K L +++ G YR P S C ++R L++NP +
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290
Query: 298 RCTLEQIMKDKWINIGYE---GEELKPY 322
R TLE + W+N GY GE+ P+
Sbjct: 291 RATLEDVASHWWVNWGYATRVGEQEAPH 318
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 266 bits (681), Expect = 4e-71
Identities = 176/516 (34%), Positives = 261/516 (50%), Gaps = 20/516 (3%)
Query: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVRIMKGLNHPN 117
Y L T+GKG + KVK A +GR VAIK I K ++ + + + RE+ IM LNHP+
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 118 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNI 177
I+ ++EV E + + ++MEYAS GE++DY+ R+ E+E R FRQIVSAVHYCH+ +
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 178 VHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEV 237
VHRDLK EN+LLD NIKIADFG SN + L TFCGSP YA+PE+ G+ Y GPEV
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 238 DIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAK 297
D W+LGV+LYTLV G++PFDG + K L ++ G+YR P S D ++R L++NP +
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDR 293
Query: 298 RCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRI----EVMVGMGYTREEIKESLT 353
R T+E I W+N GY+ + + RI G+ E + L
Sbjct: 294 RATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLA 353
Query: 354 SQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSS 413
+EV +K+++ D A + A ++ + SS + K + +S
Sbjct: 354 KPTTSEVMLERQRSLKKSKKEND-----FAQSGQDAVPESPSKLSSKRPKGILKKRSNSE 408
Query: 414 STYHRQRRHSDFCGPS-PAPLHPKRSPTSTGE--AELKEERLPGRKASCSTAGSGSRGLP 470
H GP+ P+ ++ TG E +PG+ + +A +G+
Sbjct: 409 HRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGIL 468
Query: 471 PSSPMVSSAH--NPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPN 528
+ S + +P ++E E DS + PS V + R +L +
Sbjct: 469 KKTQQRESGYYSSPERSESSE-LLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKH 527
Query: 529 GKENSSGT---PRVPPASPSSHSLAPPSGERSRLAR 561
+ S+GT V P P+ SL+ P L+R
Sbjct: 528 SSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSR 563
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 259 bits (661), Expect = 8e-69
Identities = 138/316 (43%), Positives = 196/316 (62%), Gaps = 17/316 (5%)
Query: 51 EEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLF 104
E+Q H +G+Y L T+G G F KVK+ H LTG +VA+KI+++ ++ + K+
Sbjct: 3 EKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK 62
Query: 105 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQ 164
RE++ +K HP+I+KL++VI T ++VMEY S GE+FDY+ HGR++E EAR F+Q
Sbjct: 63 REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ 122
Query: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAP 224
I+SAV YCH+ +VHRDLK EN+LLDA N KIADFG SN + G L T CGSP YAAP
Sbjct: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182
Query: 225 ELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCE 284
E+ G+ Y GPEVDIWS GVILY L+ G+LPFD ++ L +++ G + +P Y++
Sbjct: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA 242
Query: 285 SILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRI------EVM 338
++L L ++P KR T++ I + +W ++L Y PE+ D I EV
Sbjct: 243 TLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEVC 297
Query: 339 VGMGYTREEIKESLTS 354
T E+ SL S
Sbjct: 298 EKFECTESEVMNSLYS 313
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 255 bits (652), Expect = 8e-68
Identities = 137/360 (38%), Positives = 212/360 (58%), Gaps = 10/360 (2%)
Query: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 115
+G YR+ IG GNF++VKL H LT +VAIKI+DKT+L+ + + L RE+ M+ L+H
Sbjct: 71 IGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHH 130
Query: 116 PNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175
PNI++L+EV+ET L+LVMEYA GE+F + + G++ E E++ F QIVSAV + H+
Sbjct: 131 PNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHEN 190
Query: 176 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
I+HRDLKAEN+ + +K+ DFGFS G L+TFCGSPPYAAPELF+ + Y G
Sbjct: 191 QIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGI 250
Query: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295
VDIW+LGV+LY +V+G++PF + +L++ +L G Y VP ++S C ++R L P
Sbjct: 251 YVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIP 310
Query: 296 AKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIE--------VMVGMGYTREE 347
+R ++ IM D+W+ L+P+ + +T ++ + +G T E
Sbjct: 311 TERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITEEH 370
Query: 348 IKESLTSQKYNEVTATY-LLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHS 406
I+ + + +T Y ++L R + P + L + D G+ +G H+
Sbjct: 371 IRNNQGRDARSSITGVYRIILHRVQRKKALESVPVMMLPDPK-ERDLKKGSRVYRGIRHT 429
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 254 bits (649), Expect = 2e-67
Identities = 128/283 (45%), Positives = 187/283 (66%), Gaps = 11/283 (3%)
Query: 51 EEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLF 104
E+Q H +G+Y L T+G G F KVK+ +H LTG +VA+KI+++ ++ + K+
Sbjct: 14 EKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR 73
Query: 105 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQ 164
RE++ +K HP+I+KL++VI T +++VMEY S GE+FDY+ +GR+ EKE+R F+Q
Sbjct: 74 REIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQ 133
Query: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAP 224
I+S V YCH+ +VHRDLK EN+LLDA N KIADFG SN + G L T CGSP YAAP
Sbjct: 134 ILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 193
Query: 225 ELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCE 284
E+ G+ Y GPEVDIWS GVILY L+ G+LPFD ++ L +++ G + P Y++
Sbjct: 194 EVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVI 253
Query: 285 SILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEE 327
S+L+ L ++P KR T++ I + +W ++L Y PE+
Sbjct: 254 SLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 291
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 251 bits (642), Expect = 1e-66
Identities = 138/323 (42%), Positives = 197/323 (60%), Gaps = 13/323 (4%)
Query: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 118
Y L TIG G FAKVKLA HILTG VAIKI+DK L S L ++ E+ +K L H +I
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLRHQHI 69
Query: 119 VKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIV 178
+L+ V+ET +++V+EY GE+FDY++S R+ E+E R FRQIVSAV Y H +
Sbjct: 70 CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA 129
Query: 179 HRDLKAENLLLDAEANIKIADFGFSNEFTLGSK---LDTFCGSPPYAAPELFQGKKYDGP 235
HRDLK ENLL D +K+ DFG + G+K L T CGS YAAPEL QGK Y G
Sbjct: 130 HRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188
Query: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNP 295
E D+WS+G++LY L+ G LPFD N+ L ++++RGKY VP ++S +L++ L ++P
Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDP 248
Query: 296 AKRCTLEQIMKDKWI----NIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKES 351
KR +++ ++ WI N E + P+ ++D E+ V R+ +++
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDC----VTELSVHHRNNRQTMEDL 304
Query: 352 LTSQKYNEVTATYLLLGRKTEEG 374
++ +Y+ +TATYLLL K G
Sbjct: 305 ISLWQYDHLTATYLLLLAKKARG 327
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 244 bits (623), Expect = 2e-64
Identities = 128/298 (42%), Positives = 187/298 (62%), Gaps = 26/298 (8%)
Query: 51 EEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLF 104
E+Q H +G+Y L T+G G F KVK+ +H LTG +VA+KI+++ ++ + K+
Sbjct: 14 EKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR 73
Query: 105 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR------------ 152
RE++ +K HP+I+KL++VI T +++VMEY S GE+FDY+ +GR
Sbjct: 74 REIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGS 133
Query: 153 ---MKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLG 209
+ EKE+R F+QI+S V YCH+ +VHRDLK EN+LLDA N KIADFG SN + G
Sbjct: 134 TKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG 193
Query: 210 SKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVL 269
L T CGSP YAAPE+ G+ Y GPEVDIWS GVILY L+ G+LPFD ++ L +++
Sbjct: 194 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKIC 253
Query: 270 RGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEE 327
G + P Y++ S+L+ L ++P KR T++ I + +W ++L Y PE+
Sbjct: 254 DGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK-----QDLPKYLFPED 306
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 228 bits (582), Expect = 1e-59
Identities = 136/378 (35%), Positives = 211/378 (55%), Gaps = 19/378 (5%)
Query: 8 APGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL-LRTIG 66
APG ++ + P+W S R R+ + VGNY + R +G
Sbjct: 15 APGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDF-----QHHKRVGNYLIGSRKLG 69
Query: 67 KGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL--QKLFREVRIMKGLNHPNIVKLFEV 124
+G+FAKV+ H+LTG +VAIK+IDK + + + L RE +I + + HPNI +L ++
Sbjct: 70 EGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDI 129
Query: 125 IETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKA 184
+ETE + YLVME G + + R++E EAR RQ++SAV + H+ +VHRDLK
Sbjct: 130 LETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKI 189
Query: 185 ENLLLDAEANIKIADFGFSNEFTLGSKLDTF---CGSPPYAAPELFQGKKYDGPEVDIWS 241
ENLLLD + NIK+ DFG SN + D F CGSP YAAPEL KKY GP++D+WS
Sbjct: 190 ENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWS 248
Query: 242 LGVILYTLVSGSLPF--DGHNLKELRERVLRGKYR-VPFYMSTDCESILRRFLVLNPAKR 298
+GV +Y +++G+LPF + +L+ L ++++ + +P +ST S LR L +P KR
Sbjct: 249 IGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKR 308
Query: 299 CTLEQIMKDKWINIGYEGEELKPYTEPE----EDFGDTKRIEVMVGMGYTREEIKESLTS 354
++Q + ++W+N Y G+ T P ED + + + +GY ++ ++ S
Sbjct: 309 PNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLS 368
Query: 355 QKYNEVTATYLLLGRKTE 372
+ + A Y LL +K E
Sbjct: 369 NRACHILAIYFLLNKKLE 386
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 187 bits (474), Expect = 4e-47
Identities = 104/263 (39%), Positives = 158/263 (60%), Gaps = 13/263 (4%)
Query: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVRIMKGLNHPN 117
Y L +G+G++AKVK A VAIKIID+ + L+K RE+ I+ LNH +
Sbjct: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Query: 118 IVKLFEVIETEK-TLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN 176
I+K +E+ ET +Y+VME A G++ + + + G + E EAR KF Q+ A+ YCH +
Sbjct: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
Query: 177 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQGKK 231
+VHRDLK +NLLLD + NIK++DF FS TFCGSP YAAPE+ QG
Sbjct: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
Query: 232 YDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF----YMSTDCESIL 287
Y DIWSLGVILY +V GS+P+D N+K++ ++ ++RV F +++ +C+ ++
Sbjct: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Query: 288 RRFLVLNPAKRCTLEQIMKDKWI 310
L + +R +++I+ W+
Sbjct: 250 YHMLQPDVNRRLHIDEILSHCWM 272
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 182 bits (463), Expect = 7e-46
Identities = 99/257 (38%), Positives = 160/257 (62%), Gaps = 6/257 (2%)
Query: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVRIMKGLNHPN 117
Y+L +TIG+G ++KVK A R+VAIK+IDK +Q+ RE++I++ L+H N
Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Query: 118 IVKLFEVIET-EKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN 176
I++++E++E+ + + LVME A G+VFD +++ G + E A+A FRQ+V A+ YCH
Sbjct: 70 IIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCG 129
Query: 177 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK--LDTFCGSPPYAAPELFQGKKYDG 234
+ HRDLK EN LL N+K+ DFGF+ + TFCGS YAAPE+ QG +D
Sbjct: 130 VAHRDLKCENALLQG-FNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDS 188
Query: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG-KYRVPFYMSTDCESILRRFLVL 293
+ D+WS+GV+LY ++ SLPFD ++ ++ + +G + +S DC+ +L+R L
Sbjct: 189 KKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEP 248
Query: 294 NPAKRCTLEQIMKDKWI 310
+ R ++E++ W+
Sbjct: 249 DMILRPSIEEVSWHPWL 265
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 182 bits (463), Expect = 7e-46
Identities = 99/257 (38%), Positives = 157/257 (61%), Gaps = 13/257 (5%)
Query: 65 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVRIMKGLNHPNIVKLFE 123
+GKG++AKVK A VA+KIID+ + +++ RE+ I+ +NH +I+K +E
Sbjct: 18 LGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYE 77
Query: 124 VIET-EKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDL 182
+ ET + +Y++ME G++ +++ G + E AR FRQ+ SAV YCH +IVHRDL
Sbjct: 78 IFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDL 137
Query: 183 KAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQGKKYDGPEV 237
K ENLLLD + NIK++DFGFS S TFCGS YAAPE+ Q Y
Sbjct: 138 KCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVY 197
Query: 238 DIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF----YMSTDCESILRRFLVL 293
DIWSLGVILY +V GS+P+D +++++ ++ ++RV F ++ +C+ ++ R L
Sbjct: 198 DIWSLGVILYIMVCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLTCECKDLIYRMLQP 255
Query: 294 NPAKRCTLEQIMKDKWI 310
+ ++R +++I+ W+
Sbjct: 256 DVSQRLHIDEILSHSWL 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,972,831
Number of Sequences: 37866
Number of extensions: 1681988
Number of successful extensions: 12761
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 774
Number of HSP's successfully gapped in prelim test: 629
Number of HSP's that attempted gapping in prelim test: 8419
Number of HSP's gapped (non-prelim): 2848
length of query: 688
length of database: 18,247,518
effective HSP length: 109
effective length of query: 579
effective length of database: 14,120,124
effective search space: 8175551796
effective search space used: 8175551796
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.