BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|33589861 RAB31, member RAS oncogene family [Homo sapiens] (195 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|33589861 RAB31, member RAS oncogene family [Homo sapiens] 400 e-112 gi|10190714 RAS-related protein RAB-22A [Homo sapiens] 276 1e-74 gi|19923262 RAB5A, member RAS oncogene family [Homo sapiens] 185 2e-47 gi|41393614 RAB5C, member RAS oncogene family isoform a [Homo sa... 181 5e-46 gi|41393545 RAB5C, member RAS oncogene family isoform b [Homo sa... 181 5e-46 gi|4506371 RAB5B, member RAS oncogene family [Homo sapiens] 177 7e-45 gi|4758988 RAB1A, member RAS oncogene family isoform 1 [Homo sap... 151 3e-37 gi|19923231 RAB6A, member RAS oncogene family isoform a [Homo sa... 150 9e-37 gi|116812567 RAB25 [Homo sapiens] 149 1e-36 gi|7661922 RAB21, member RAS oncogene family [Homo sapiens] 149 1e-36 gi|38679888 RAB6A, member RAS oncogene family isoform b [Homo sa... 147 7e-36 gi|96975097 RAB6B, member RAS oncogene family [Homo sapiens] 147 7e-36 gi|4758984 Ras-related protein Rab-11A [Homo sapiens] 146 1e-35 gi|190358517 RAB11B, member RAS oncogene family [Homo sapiens] 145 2e-35 gi|13569962 RAB1B, member RAS oncogene family [Homo sapiens] 145 2e-35 gi|117938299 RAB6C-like [Homo sapiens] 144 6e-35 gi|11967981 RAB17, member RAS oncogene family [Homo sapiens] 143 1e-34 gi|7706563 RAB8B, member RAS oncogene family [Homo sapiens] 140 9e-34 gi|33695095 ras-related GTP-binding protein RAB10 [Homo sapiens] 139 1e-33 gi|116875763 RAB6C, member RAS oncogene family [Homo sapiens] 139 2e-33 gi|4506363 RAB13, member RAS oncogene family [Homo sapiens] 138 3e-33 gi|21361418 RAB30, member RAS oncogene family [Homo sapiens] 137 8e-33 gi|16933567 mel transforming oncogene [Homo sapiens] 136 1e-32 gi|74096429 RAB41, member RAS oncogene family [Homo sapiens] 135 2e-32 gi|4506365 RAB2A, member RAS oncogene family [Homo sapiens] 135 2e-32 gi|10880989 RAB18, member RAS oncogene family [Homo sapiens] 134 5e-32 gi|21361884 RAB2B protein isoform 1 [Homo sapiens] 134 6e-32 gi|169204777 PREDICTED: similar to RAB13, member RAS oncogene fa... 134 6e-32 gi|169205558 PREDICTED: similar to hCG24991 [Homo sapiens] 134 6e-32 gi|169204174 PREDICTED: similar to hCG24991 [Homo sapiens] 134 6e-32 >gi|33589861 RAB31, member RAS oncogene family [Homo sapiens] Length = 195 Score = 400 bits (1027), Expect = e-112 Identities = 195/195 (100%), Positives = 195/195 (100%) Query: 1 MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIW 60 MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIW Sbjct: 1 MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIW 60 Query: 61 DTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNK 120 DTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNK Sbjct: 61 DTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNK 120 Query: 121 CDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNGT 180 CDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNGT Sbjct: 121 CDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNGT 180 Query: 181 IKVEKPTMQASRRCC 195 IKVEKPTMQASRRCC Sbjct: 181 IKVEKPTMQASRRCC 195 >gi|10190714 RAS-related protein RAB-22A [Homo sapiens] Length = 194 Score = 276 bits (705), Expect = 1e-74 Identities = 138/194 (71%), Positives = 158/194 (81%) Query: 2 MAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWD 61 MA+RELKVCLLGDTGVGKSSIV RFV+D FD NI+PTIGASFMTKTV NELHKFLIWD Sbjct: 1 MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWD 60 Query: 62 TAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKC 121 TAGQERF +LAPMYYRGSAAA+IVYDITK+++F TLK WVKEL++HGP NIV+AIAGNKC Sbjct: 61 TAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKELRQHGPPNIVVAIAGNKC 120 Query: 122 DLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNGTI 181 DL D+REV +DAK+YA+SI AI VETSAKNAINI ELF ISR+IP D + Sbjct: 121 DLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANLPSGGKGF 180 Query: 182 KVEKPTMQASRRCC 195 K+ + + R CC Sbjct: 181 KLRRQPSEPKRSCC 194 >gi|19923262 RAB5A, member RAS oncogene family [Homo sapiens] Length = 215 Score = 185 bits (470), Expect = 2e-47 Identities = 90/196 (45%), Positives = 131/196 (66%), Gaps = 4/196 (2%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 I + K+ LLG++ VGKSS+V RFV+ F TIGA+F+T+TV + KF IWDTA Sbjct: 18 ICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTA 77 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQER+HSLAPMYYRG+ AA++VYDIT ++SF K WVKEL+ NIV+A++GNK DL Sbjct: 78 GQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADL 137 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNGT--- 180 ++ R V ++A+ YA+ + +ETSAK ++N+ E+F I++++P +P G N Sbjct: 138 ANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGR 197 Query: 181 -IKVEKPTMQASRRCC 195 + + +PT +CC Sbjct: 198 GVDLTEPTQPTRNQCC 213 >gi|41393614 RAB5C, member RAS oncogene family isoform a [Homo sapiens] Length = 216 Score = 181 bits (458), Expect = 5e-46 Identities = 90/196 (45%), Positives = 129/196 (65%), Gaps = 4/196 (2%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 I + K+ LLG++ VGKSS+V RFV+ F TIGA+F+T+TV + KF IWDTA Sbjct: 19 ICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTA 78 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQER+HSLAPMYYRG+ AA++VYDIT D+F K WVKEL+ NIV+A+AGNK DL Sbjct: 79 GQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADL 138 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHE----NGNNG 179 + R V ++A+ YA+ + +ETSAK A+N+ E+F I++++P +P G N Sbjct: 139 ASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNATGAPGRNR 198 Query: 180 TIKVEKPTMQASRRCC 195 + +++ + +CC Sbjct: 199 GVDLQENNPASRSQCC 214 >gi|41393545 RAB5C, member RAS oncogene family isoform b [Homo sapiens] Length = 216 Score = 181 bits (458), Expect = 5e-46 Identities = 90/196 (45%), Positives = 129/196 (65%), Gaps = 4/196 (2%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 I + K+ LLG++ VGKSS+V RFV+ F TIGA+F+T+TV + KF IWDTA Sbjct: 19 ICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTA 78 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQER+HSLAPMYYRG+ AA++VYDIT D+F K WVKEL+ NIV+A+AGNK DL Sbjct: 79 GQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNIVIALAGNKADL 138 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHE----NGNNG 179 + R V ++A+ YA+ + +ETSAK A+N+ E+F I++++P +P G N Sbjct: 139 ASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMAIAKKLPKNEPQNATGAPGRNR 198 Query: 180 TIKVEKPTMQASRRCC 195 + +++ + +CC Sbjct: 199 GVDLQENNPASRSQCC 214 >gi|4506371 RAB5B, member RAS oncogene family [Homo sapiens] Length = 215 Score = 177 bits (448), Expect = 7e-45 Identities = 88/196 (44%), Positives = 131/196 (66%), Gaps = 4/196 (2%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 I + K+ LLG++ VGKSS+V RFV+ F TIGA+F+T++V + KF IWDTA Sbjct: 18 ICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTA 77 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQER+HSLAPMYYRG+ AA++VYDIT Q++F K WVKEL+ +IV+A+AGNK DL Sbjct: 78 GQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADL 137 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHE----NGNNG 179 ++ R V ++A+ YA+ + +ETSAK A+N+ +LF I++++P +P G + Sbjct: 138 ANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSR 197 Query: 180 TIKVEKPTMQASRRCC 195 + + + + Q +CC Sbjct: 198 GVDLHEQSQQNKSQCC 213 >gi|4758988 RAB1A, member RAS oncogene family isoform 1 [Homo sapiens] Length = 205 Score = 151 bits (382), Expect = 3e-37 Identities = 74/193 (38%), Positives = 114/193 (59%), Gaps = 5/193 (2%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGKS ++ RF D + + TIG F +T+ + K IWDTAGQER Sbjct: 13 KLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQER 72 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F ++ YYRG+ ++VYD+T Q+SF +K+W++E+ + EN+ + GNKCDL+ + Sbjct: 73 FRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKK 132 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQ----GISRQIPPLDPHENGNNGTIKV 183 V AKE+A+S+G +ETSAKNA N+E+ F I +++ P +K+ Sbjct: 133 VVDYTTAKEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKI 192 Query: 184 EK-PTMQASRRCC 195 + P Q+ CC Sbjct: 193 QSTPVKQSGGGCC 205 >gi|19923231 RAB6A, member RAS oncogene family isoform a [Homo sapiens] Length = 208 Score = 150 bits (378), Expect = 9e-37 Identities = 71/189 (37%), Positives = 120/189 (63%), Gaps = 3/189 (1%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 +R+ K+ LG+ VGK+S++ RF+ D FD+ TIG F++KT+ + + +WDTA Sbjct: 11 LRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTA 70 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQERF SL P Y R SAAAV+VYDIT +SF KW+ +++ ++++ + GNK DL Sbjct: 71 GQERFRSLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDL 130 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNG---T 180 +D R+V +++ + A+ + + +ETSAK N+++LF+ ++ +P ++ ++ + Sbjct: 131 ADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMID 190 Query: 181 IKVEKPTMQ 189 IK+EKP Q Sbjct: 191 IKLEKPQEQ 199 >gi|116812567 RAB25 [Homo sapiens] Length = 213 Score = 149 bits (376), Expect = 1e-36 Identities = 67/160 (41%), Positives = 109/160 (68%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 KV L+G++GVGK++++ RF ++ F H+ TIG F T+TV G K IWDTAG ER Sbjct: 14 KVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLER 73 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 + ++ YYRG+ A++V+D+TK ++ +++W+KEL +H IV+ + GNK DLS R Sbjct: 74 YRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAR 133 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 EVP ++A+ +AE+ G + +ETSA ++ N+E F+ + ++I Sbjct: 134 EVPTEEARMFAENNGLLFLETSALDSTNVELAFETVLKEI 173 >gi|7661922 RAB21, member RAS oncogene family [Homo sapiens] Length = 225 Score = 149 bits (376), Expect = 1e-36 Identities = 79/176 (44%), Positives = 110/176 (62%), Gaps = 3/176 (1%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 KV LLG+ VGK+S+V R+ ++ F+ T+ ASF+TK + G + IWDTAGQER Sbjct: 21 KVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQER 80 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 FH+L P+YYR S A++VYDIT +DSF +K WVKEL++ I + I GNK DL R Sbjct: 81 FHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKER 140 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI---PPLDPHENGNNGT 180 V +++A+ YAES+GA TSAK IEELF + +++ +D GN + Sbjct: 141 HVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSS 196 >gi|38679888 RAB6A, member RAS oncogene family isoform b [Homo sapiens] Length = 208 Score = 147 bits (370), Expect = 7e-36 Identities = 69/189 (36%), Positives = 118/189 (62%), Gaps = 3/189 (1%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 +R+ K+ LG+ VGK+S++ RF+ D FD+ TIG F++KT+ + + +WDTA Sbjct: 11 LRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTA 70 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQERF SL P Y R S AV+VYDIT +SF KW+ +++ ++++ + GNK DL Sbjct: 71 GQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDL 130 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNG---T 180 +D R+V +++ + A+ + + +ETSAK N+++LF+ ++ +P ++ ++ + Sbjct: 131 ADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMID 190 Query: 181 IKVEKPTMQ 189 IK+EKP Q Sbjct: 191 IKLEKPQEQ 199 >gi|96975097 RAB6B, member RAS oncogene family [Homo sapiens] Length = 208 Score = 147 bits (370), Expect = 7e-36 Identities = 68/186 (36%), Positives = 117/186 (62%), Gaps = 3/186 (1%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 +R+ K+ LG+ VGK+S++ RF+ D FD+ TIG F++KT+ + + +WDTA Sbjct: 11 LRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTA 70 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQERF SL P Y R S AV+VYDIT +SF KW+ +++ ++++ + GNK DL Sbjct: 71 GQERFRSLIPSYIRDSTVAVVVYDITNLNSFQQTSKWIDDVRTERGSDVIIMLVGNKTDL 130 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLD-PHENGNNG--T 180 +D R++ +++ ++ A+ + + +ETSAK N+++LF+ ++ +P ++ E G Sbjct: 131 ADKRQITIEEGEQRAKELSVMFIETSAKTGYNVKQLFRRVASALPGMENVQEKSKEGMID 190 Query: 181 IKVEKP 186 IK++KP Sbjct: 191 IKLDKP 196 >gi|4758984 Ras-related protein Rab-11A [Homo sapiens] Length = 216 Score = 146 bits (369), Expect = 1e-35 Identities = 68/160 (42%), Positives = 105/160 (65%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 KV L+GD+GVGKS+++ RF ++ F+ TIG F T+++ + K IWDTAGQER Sbjct: 13 KVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQER 72 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 + ++ YYRG+ A++VYDI K ++ +++W+KEL++H NIV+ + GNK DL +R Sbjct: 73 YRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLR 132 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 VP +A+ +AE G +ETSA ++ N+E FQ I +I Sbjct: 133 AVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEI 172 >gi|190358517 RAB11B, member RAS oncogene family [Homo sapiens] Length = 218 Score = 145 bits (367), Expect = 2e-35 Identities = 67/160 (41%), Positives = 105/160 (65%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 KV L+GD+GVGKS+++ RF ++ F+ TIG F T+++ + K IWDTAGQER Sbjct: 13 KVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQER 72 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 + ++ YYRG+ A++VYDI K ++ +++W+KEL++H NIV+ + GNK DL +R Sbjct: 73 YRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLR 132 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 VP +A+ +AE +ETSA ++ N+EE F+ I +I Sbjct: 133 AVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEI 172 >gi|13569962 RAB1B, member RAS oncogene family [Homo sapiens] Length = 201 Score = 145 bits (367), Expect = 2e-35 Identities = 73/192 (38%), Positives = 114/192 (59%), Gaps = 4/192 (2%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGKS ++ RF D + + TIG F +T+ + K IWDTAGQER Sbjct: 10 KLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQER 69 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F ++ YYRG+ ++VYD+T Q+S+ +K+W++E+ + EN+ + GNK DL+ + Sbjct: 70 FRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKK 129 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPP-LDP--HENGNNGTIKVE 184 V AKE+A+S+G +ETSAKNA N+E+ F ++ +I + P G +K++ Sbjct: 130 VVDNTTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKID 189 Query: 185 K-PTMQASRRCC 195 P A CC Sbjct: 190 STPVKPAGGGCC 201 >gi|117938299 RAB6C-like [Homo sapiens] Length = 254 Score = 144 bits (362), Expect = 6e-35 Identities = 69/189 (36%), Positives = 115/189 (60%), Gaps = 3/189 (1%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 +R+ K+ LG+ V K+S++ RF D FD+ IG F++KT+ + +WDTA Sbjct: 11 LRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLWDTA 70 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQER SL P Y R SAAAV+VYDIT +SF KW+ +++ G ++++ + GNK DL Sbjct: 71 GQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTEGGSDVIITLVGNKTDL 130 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNN---GT 180 +D R+V +++ + A+ + +ET AK N+++LF+ ++ +P ++ ++G+ Sbjct: 131 ADKRQVSIEEGERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSREDMSD 190 Query: 181 IKVEKPTMQ 189 IK+EKP Q Sbjct: 191 IKLEKPQEQ 199 >gi|11967981 RAB17, member RAS oncogene family [Homo sapiens] Length = 212 Score = 143 bits (360), Expect = 1e-34 Identities = 78/196 (39%), Positives = 121/196 (61%), Gaps = 8/196 (4%) Query: 5 RELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAG 64 R K+ LLG VGKSS+ R+V++ F +I PT+G +F TK V G K IWDTAG Sbjct: 18 RVFKLVLLGSGSVGKSSLALRYVKNDFK-SILPTVGCAFFTKVVDVGATSLKLEIWDTAG 76 Query: 65 QERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEH-GPENIVMAIAGNKCDL 123 QE++HS+ +Y+RG+ AA++VYDIT++DSF ++W+K+L+E P +++ + GNK DL Sbjct: 77 QEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDL 136 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHE----NGNNG 179 S REV ++ KE+A+S + +ETSAK + E+F +++++ E G+ Sbjct: 137 SQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAA 196 Query: 180 TIKVEKPTMQASRRCC 195 + P QA +CC Sbjct: 197 VALNKGPARQA--KCC 210 >gi|7706563 RAB8B, member RAS oncogene family [Homo sapiens] Length = 207 Score = 140 bits (352), Expect = 9e-34 Identities = 69/182 (37%), Positives = 108/182 (59%), Gaps = 6/182 (3%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGK+ ++ RF +D F+ TIG F +T+ + K IWDTAGQER Sbjct: 10 KLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQER 69 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F ++ YYRG+ ++VYDIT + SF +K W++ ++EH ++ I GNKCD++D R Sbjct: 70 FRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKR 129 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPL------DPHENGNNGTI 181 +V + ++ A G +ETSAK++ N+EE F ++R I D + G G + Sbjct: 130 QVSKERGEKLAIDYGIKFLETSAKSSANVEEAFFTLARDIMTKLNRKMNDSNSAGAGGPV 189 Query: 182 KV 183 K+ Sbjct: 190 KI 191 >gi|33695095 ras-related GTP-binding protein RAB10 [Homo sapiens] Length = 200 Score = 139 bits (351), Expect = 1e-33 Identities = 77/192 (40%), Positives = 104/192 (54%), Gaps = 6/192 (3%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGK+ ++ RF D F+ TIG F KTV + K IWDTAGQER Sbjct: 11 KLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQER 70 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 FH++ YYRG+ ++VYDIT SF + KW++ + EH E++ + GNKCD+ D R Sbjct: 71 FHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKR 130 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELF----QGISRQIPPLDPHENGNNGTIKV 183 VP + A G ETSAK INIE+ F + I R+ P +P N N I Sbjct: 131 VVPKGKGGQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEP--NSENVDISS 188 Query: 184 EKPTMQASRRCC 195 +CC Sbjct: 189 GGGVTGWKSKCC 200 >gi|116875763 RAB6C, member RAS oncogene family [Homo sapiens] Length = 254 Score = 139 bits (350), Expect = 2e-33 Identities = 67/189 (35%), Positives = 114/189 (60%), Gaps = 3/189 (1%) Query: 4 IRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTA 63 +R+ K+ LG+ V K+S++ RF D FD+ IG F++KT+ + +WDTA Sbjct: 11 LRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLWDTA 70 Query: 64 GQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDL 123 GQER SL P Y R SAAAV+VYDIT +SF KW+ +++ ++++ + GN+ DL Sbjct: 71 GQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIITLVGNRTDL 130 Query: 124 SDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNN---GT 180 +D R+V +++ + A+ + +ET AK N+++LF+ ++ +P ++ ++G+ Sbjct: 131 ADKRQVSVEEGERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSREDMSD 190 Query: 181 IKVEKPTMQ 189 IK+EKP Q Sbjct: 191 IKLEKPQEQ 199 >gi|4506363 RAB13, member RAS oncogene family [Homo sapiens] Length = 203 Score = 138 bits (347), Expect = 3e-33 Identities = 63/160 (39%), Positives = 100/160 (62%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGK+ ++ RF +D+F++ TIG F +TV + K +WDTAGQER Sbjct: 10 KLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQER 69 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F ++ YYRG+ ++VYDIT + SF ++ W+K +KE+ + + GNKCD+ R Sbjct: 70 FKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERLLLGNKCDMEAKR 129 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 +V + A + A G ETSAK+++N++E F ++R I Sbjct: 130 KVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDI 169 >gi|21361418 RAB30, member RAS oncogene family [Homo sapiens] Length = 203 Score = 137 bits (344), Expect = 8e-33 Identities = 66/153 (43%), Positives = 98/153 (64%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+G+ GVGK+ +V RF Q F TIG FM KTV E K IWDTAGQER Sbjct: 11 KIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEINGEKVKLQIWDTAGQER 70 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F S+ YYR + A ++ YDIT ++SF L +W++E++++ ++ + GNK DL++ R Sbjct: 71 FRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERR 130 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELF 160 EV + A+E++E+ +ETSAK + N+E+LF Sbjct: 131 EVSQQRAEEFSEAQDMYYLETSAKESDNVEKLF 163 >gi|16933567 mel transforming oncogene [Homo sapiens] Length = 207 Score = 136 bits (343), Expect = 1e-32 Identities = 67/172 (38%), Positives = 104/172 (60%), Gaps = 1/172 (0%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGK+ ++ RF +D F+ TIG F +T+ + K IWDTAGQER Sbjct: 10 KLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQER 69 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F ++ YYRG+ ++VYDIT + SF ++ W++ ++EH ++ I GNKCD++D R Sbjct: 70 FRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKR 129 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI-PPLDPHENGNN 178 +V + ++ A G +ETSAK IN+E F ++R I +D GN+ Sbjct: 130 QVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNS 181 >gi|74096429 RAB41, member RAS oncogene family [Homo sapiens] Length = 222 Score = 135 bits (341), Expect = 2e-32 Identities = 65/184 (35%), Positives = 111/184 (60%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ LG+ VGK+SI+ RF+ + F T+G F++KT+ +++ + +WDTAGQER Sbjct: 33 KLLFLGEQSVGKTSIISRFMYNSFGCACQATVGIDFLSKTMYLEDQIVQLQLWDTAGQER 92 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 FHSL P Y R S AV+VYDIT +SF KWV+ ++ +++V+ + GNK DL + R Sbjct: 93 FHSLIPSYIRDSTIAVVVYDITNINSFKETDKWVEHVRAERGDDVVIMLLGNKIDLDNKR 152 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNGTIKVEKPT 187 +V + +E + ++ + +ETSAK N+++LF+ ++ + GT+++E + Sbjct: 153 QVTAEQGEEKSRNLNVMFIETSAKTGYNVKKLFRRVASALLSTRTSPPPKEGTVEIELES 212 Query: 188 MQAS 191 + S Sbjct: 213 FEES 216 >gi|4506365 RAB2A, member RAS oncogene family [Homo sapiens] Length = 212 Score = 135 bits (340), Expect = 2e-32 Identities = 66/160 (41%), Positives = 98/160 (61%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K ++GDTGVGKS ++ +F F TIG F + + + K IWDTAGQE Sbjct: 8 KYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQES 67 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F S+ YYRG+A A++VYDIT++D+F L W+++ ++H N+V+ + GNK DL R Sbjct: 68 FRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRR 127 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 EV ++ + +A G I +ETSAK A N+EE F +++I Sbjct: 128 EVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEI 167 >gi|10880989 RAB18, member RAS oncogene family [Homo sapiens] Length = 206 Score = 134 bits (337), Expect = 5e-32 Identities = 72/192 (37%), Positives = 106/192 (55%), Gaps = 5/192 (2%) Query: 7 LKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQE 66 LK+ ++G++GVGKSS++ RF D FD ++ TIG F KT+ K IWDTAGQE Sbjct: 9 LKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWDTAGQE 68 Query: 67 RFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPEN-IVMAIAGNKCDLSD 125 RF +L P YYRG+ ++VYD+T++D+F L W+ EL+ + N IV + GNK D + Sbjct: 69 RFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKID-KE 127 Query: 126 IREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI---PPLDPHENGNNGTIK 182 REV + ++A + +E SAK ++ F+ + +I P L EN N G Sbjct: 128 NREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWESENQNKGVKL 187 Query: 183 VEKPTMQASRRC 194 + Q C Sbjct: 188 SHREEGQGGGAC 199 >gi|21361884 RAB2B protein isoform 1 [Homo sapiens] Length = 216 Score = 134 bits (336), Expect = 6e-32 Identities = 65/160 (40%), Positives = 98/160 (61%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K ++GDTGVGKS ++ +F F TIG F + V + K IWDTAGQE Sbjct: 8 KYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVNIDGKQIKLQIWDTAGQES 67 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F S+ YYRG+A A++VYDIT++++F L W+++ ++H N+V+ + GNK DL R Sbjct: 68 FRSITRSYYRGAAGALLVYDITRRETFNHLTSWLEDARQHSSSNMVIMLIGNKSDLESRR 127 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 +V ++ + +A G I +ETSAK A N+EE F +++I Sbjct: 128 DVKREEGEAFAREHGLIFMETSAKTACNVEEAFINTAKEI 167 >gi|169204777 PREDICTED: similar to RAB13, member RAS oncogene family [Homo sapiens] Length = 327 Score = 134 bits (336), Expect = 6e-32 Identities = 61/160 (38%), Positives = 98/160 (61%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGK+ ++ RF +D+F++ TIG F +TV + K +WDTAGQER Sbjct: 134 KLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQER 193 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F ++ YYRG+ ++ YDIT + SF ++ W+K + E+ + + GNKCD+ R Sbjct: 194 FKTITTAYYRGAMGIILAYDITDEKSFENIQNWMKSIMENASAGVEHLLLGNKCDMEAKR 253 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 +V + A + A G ETSAK+++N++E F ++R I Sbjct: 254 KVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDI 293 >gi|169205558 PREDICTED: similar to hCG24991 [Homo sapiens] Length = 327 Score = 134 bits (336), Expect = 6e-32 Identities = 61/160 (38%), Positives = 98/160 (61%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGK+ ++ RF +D+F++ TIG F +TV + K +WDTAGQER Sbjct: 134 KLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQER 193 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F ++ YYRG+ ++ YDIT + SF ++ W+K + E+ + + GNKCD+ R Sbjct: 194 FKTITTAYYRGAMGIILAYDITDEKSFENIQNWMKSIMENASAGVEHLLLGNKCDMEAKR 253 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 +V + A + A G ETSAK+++N++E F ++R I Sbjct: 254 KVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDI 293 >gi|169204174 PREDICTED: similar to hCG24991 [Homo sapiens] Length = 327 Score = 134 bits (336), Expect = 6e-32 Identities = 61/160 (38%), Positives = 98/160 (61%) Query: 8 KVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQER 67 K+ L+GD+GVGK+ ++ RF +D+F++ TIG F +TV + K +WDTAGQER Sbjct: 134 KLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKIKLQVWDTAGQER 193 Query: 68 FHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIR 127 F ++ YYRG+ ++ YDIT + SF ++ W+K + E+ + + GNKCD+ R Sbjct: 194 FKTITTAYYRGAMGIILAYDITDEKSFENIQNWMKSIMENASAGVEHLLLGNKCDMEAKR 253 Query: 128 EVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQI 167 +V + A + A G ETSAK+++N++E F ++R I Sbjct: 254 KVQKEQADKLAREHGIRFFETSAKSSMNVDEAFSSLARDI 293 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.135 0.406 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 7,275,317 Number of Sequences: 37866 Number of extensions: 280320 Number of successful extensions: 1173 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 199 Number of HSP's successfully gapped in prelim test: 36 Number of HSP's that attempted gapping in prelim test: 756 Number of HSP's gapped (non-prelim): 238 length of query: 195 length of database: 18,247,518 effective HSP length: 97 effective length of query: 98 effective length of database: 14,574,516 effective search space: 1428302568 effective search space used: 1428302568 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.