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Search of human proteins with 33188443
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33188443 microfilament and actin filament cross-linker
protein isoform b [Homo sapiens]
(5938 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33188443 microfilament and actin filament cross-linker protei... 1.155e+04 0.0
gi|33188445 microfilament and actin filament cross-linker protei... 7610 0.0
gi|221316624 dystonin isoform 4 [Homo sapiens] 4237 0.0
gi|221316622 dystonin isoform 3 [Homo sapiens] 4237 0.0
gi|221316618 dystonin isoform 2 [Homo sapiens] 4237 0.0
gi|34577047 dystonin isoform 1 [Homo sapiens] 4237 0.0
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 4237 0.0
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 351 1e-95
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 351 1e-95
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 351 1e-95
gi|5032285 dystrophin Dp427l isoform [Homo sapiens] 351 1e-95
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 351 1e-95
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 340 3e-92
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 328 1e-88
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 316 4e-85
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 270 3e-71
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 262 9e-69
gi|110611228 utrophin [Homo sapiens] 259 7e-68
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 258 2e-67
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens] 249 8e-65
gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens] 249 8e-65
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 229 5e-59
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 220 3e-56
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 203 4e-51
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 203 4e-51
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 201 2e-50
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 201 2e-50
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 187 4e-46
gi|55770834 centromere protein F [Homo sapiens] 171 2e-41
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 170 3e-41
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 1.155e+04 bits (29971), Expect = 0.0
Identities = 5938/5938 (100%), Positives = 5938/5938 (100%)
Query: 1 MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA 60
MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA
Sbjct: 1 MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA 60
Query: 61 LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGL 120
LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGL
Sbjct: 61 LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGL 120
Query: 121 ISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSL 180
ISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSL
Sbjct: 121 ISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSL 180
Query: 181 KSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA 240
KSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA
Sbjct: 181 KSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA 240
Query: 241 CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEIL 300
CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEIL
Sbjct: 241 CAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEIL 300
Query: 301 PITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSI 360
PITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSI
Sbjct: 301 PITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSI 360
Query: 361 CIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR 420
CIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR
Sbjct: 361 CIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQR 420
Query: 421 LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLP 480
LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLP
Sbjct: 421 LLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLP 480
Query: 481 EFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINK 540
EFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINK
Sbjct: 481 EFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINK 540
Query: 541 VKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH 600
VKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH
Sbjct: 541 VKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEH 600
Query: 601 QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGN 660
QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGN
Sbjct: 601 QPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGN 660
Query: 661 VHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELL 720
VHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELL
Sbjct: 661 VHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELL 720
Query: 721 EEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT 780
EEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT
Sbjct: 721 EEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQT 780
Query: 781 CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATR 840
CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATR
Sbjct: 781 CESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATR 840
Query: 841 ILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLI 900
ILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLI
Sbjct: 841 ILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLI 900
Query: 901 SLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN 960
SLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN
Sbjct: 901 SLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDN 960
Query: 961 AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAF 1020
AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAF
Sbjct: 961 AFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAF 1020
Query: 1021 TGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDI 1080
TGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDI
Sbjct: 1021 TGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDI 1080
Query: 1081 ESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK 1140
ESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK
Sbjct: 1081 ESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGK 1140
Query: 1141 RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQ 1200
RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQ
Sbjct: 1141 RLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQ 1200
Query: 1201 IDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQ 1260
IDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQ
Sbjct: 1201 IDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQ 1260
Query: 1261 SAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ 1320
SAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ
Sbjct: 1261 SAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQ 1320
Query: 1321 VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQG 1380
VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQG
Sbjct: 1321 VSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQG 1380
Query: 1381 EVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLY 1440
EVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLY
Sbjct: 1381 EVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLY 1440
Query: 1441 QETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA 1500
QETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA
Sbjct: 1441 QETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDA 1500
Query: 1501 LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGK 1560
LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGK
Sbjct: 1501 LTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGK 1560
Query: 1561 AQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDP 1620
AQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDP
Sbjct: 1561 AQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDP 1620
Query: 1621 ARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL 1680
ARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL
Sbjct: 1621 ARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFL 1680
Query: 1681 EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETS 1740
EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETS
Sbjct: 1681 EMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETS 1740
Query: 1741 EEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTR 1800
EEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTR
Sbjct: 1741 EEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTR 1800
Query: 1801 QLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ 1860
QLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ
Sbjct: 1801 QLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQ 1860
Query: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV 1920
ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV
Sbjct: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV 1920
Query: 1921 LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQL 1980
LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQL
Sbjct: 1921 LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQL 1980
Query: 1981 DALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ 2040
DALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ
Sbjct: 1981 DALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQ 2040
Query: 2041 EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDD 2100
EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDD
Sbjct: 2041 EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDD 2100
Query: 2101 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 2160
IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE
Sbjct: 2101 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 2160
Query: 2161 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 2220
EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE
Sbjct: 2161 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 2220
Query: 2221 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLT 2280
KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLT
Sbjct: 2221 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLT 2280
Query: 2281 PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL 2340
PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL
Sbjct: 2281 PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL 2340
Query: 2341 ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI 2400
ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI
Sbjct: 2341 ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI 2400
Query: 2401 GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL 2460
GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL
Sbjct: 2401 GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL 2460
Query: 2461 LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2520
LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET
Sbjct: 2461 LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2520
Query: 2521 TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2580
TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS
Sbjct: 2521 TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2580
Query: 2581 GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQL 2640
GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQL
Sbjct: 2581 GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQL 2640
Query: 2641 CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN 2700
CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN
Sbjct: 2641 CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN 2700
Query: 2701 LEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
LEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC
Sbjct: 2701 LEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE
Sbjct: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
Query: 2821 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2880
INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK
Sbjct: 2821 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2880
Query: 2881 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2940
YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA
Sbjct: 2881 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2940
Query: 2941 QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT 3000
QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT
Sbjct: 2941 QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT 3000
Query: 3001 VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK 3060
VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK
Sbjct: 3001 VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK 3060
Query: 3061 EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 3120
EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ
Sbjct: 3061 EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 3120
Query: 3121 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180
AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV
Sbjct: 3121 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180
Query: 3181 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 3240
KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ
Sbjct: 3181 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 3240
Query: 3241 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 3300
MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL
Sbjct: 3241 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 3300
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE
Sbjct: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
Query: 3361 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 3420
DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI
Sbjct: 3361 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 3420
Query: 3421 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 3480
RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG
Sbjct: 3421 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 3480
Query: 3481 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3540
SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF
Sbjct: 3481 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3540
Query: 3541 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3600
LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE
Sbjct: 3541 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3600
Query: 3601 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3660
DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ
Sbjct: 3601 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3660
Query: 3661 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD
Sbjct: 3661 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
Query: 3721 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780
PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH
Sbjct: 3721 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780
Query: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ
Sbjct: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
Query: 3841 AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI 3900
AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI
Sbjct: 3841 AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI 3900
Query: 3901 SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3960
SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS
Sbjct: 3901 SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3960
Query: 3961 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 4020
PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL
Sbjct: 3961 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 4020
Query: 4021 SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 4080
SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL
Sbjct: 4021 SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 4080
Query: 4081 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE 4140
DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE
Sbjct: 4081 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE 4140
Query: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVS 4200
QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVS
Sbjct: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVS 4200
Query: 4201 DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA 4260
DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA
Sbjct: 4201 DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA 4260
Query: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320
FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE
Sbjct: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320
Query: 4321 RAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH 4380
RAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH
Sbjct: 4321 RAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH 4380
Query: 4381 IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEF 4440
IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEF
Sbjct: 4381 IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEF 4440
Query: 4441 HDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGE 4500
HDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGE
Sbjct: 4441 HDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGE 4500
Query: 4501 ELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAAL 4560
ELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAAL
Sbjct: 4501 ELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAAL 4560
Query: 4561 LTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACG 4620
LTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACG
Sbjct: 4561 LTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACG 4620
Query: 4621 ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL 4680
ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL
Sbjct: 4621 ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL 4680
Query: 4681 CTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREP 4740
CTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREP
Sbjct: 4681 CTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREP 4740
Query: 4741 LTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDP 4800
LTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDP
Sbjct: 4741 LTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDP 4800
Query: 4801 KVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV 4860
KVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV
Sbjct: 4801 KVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV 4860
Query: 4861 LQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHM 4920
LQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHM
Sbjct: 4861 LQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHM 4920
Query: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980
ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK
Sbjct: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980
Query: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR
Sbjct: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
Query: 5041 DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100
DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF
Sbjct: 5041 DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100
Query: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGR 5160
HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGR
Sbjct: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGR 5160
Query: 5161 ALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDW 5220
ALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDW
Sbjct: 5161 ALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDW 5220
Query: 5221 LYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDT 5280
LYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDT
Sbjct: 5221 LYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDT 5280
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG
Sbjct: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR
Sbjct: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
Query: 5401 ARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRV 5460
ARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRV
Sbjct: 5401 ARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRV 5460
Query: 5461 KALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPM 5520
KALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPM
Sbjct: 5461 KALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPM 5520
Query: 5521 PILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYM 5580
PILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYM
Sbjct: 5521 PILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYM 5580
Query: 5581 RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGY 5640
RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGY
Sbjct: 5581 RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGY 5640
Query: 5641 IDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQ 5700
IDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQ
Sbjct: 5641 IDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQ 5700
Query: 5701 FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQ 5760
FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQ
Sbjct: 5701 FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQ 5760
Query: 5761 GMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLK 5820
GMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLK
Sbjct: 5761 GMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLK 5820
Query: 5821 RPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGS 5880
RPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGS
Sbjct: 5821 RPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGS 5880
Query: 5881 DASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRTPGPKR 5938
DASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRTPGPKR
Sbjct: 5881 DASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRTPGPKR 5938
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 7610 bits (19745), Expect = 0.0
Identities = 3916/4025 (97%), Positives = 3950/4025 (98%), Gaps = 11/4025 (0%)
Query: 1916 EKTKVLNQHTQLE-GRLQDLRAWVGNKNLILNSKGSNSEI-DVDSLNLCLQQYEDLKQPM 1973
E+ KV+ + Q ++++L WV K ++SE + + + + + L + +
Sbjct: 1415 EEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEEL 1474
Query: 1974 AERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG 2033
+K Q+ Q F+++H LS ++ +Q+ LN L +++ D+ + +A Q+ LQ
Sbjct: 1475 TTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQS 1534
Query: 2034 HLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 2093
L ++ KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD
Sbjct: 1535 QLAHQTEQ---KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 1591
Query: 2094 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR 2153
LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR
Sbjct: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR 1651
Query: 2154 VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ 2213
VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ
Sbjct: 1652 VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ 1711
Query: 2214 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 2273
LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD
Sbjct: 1712 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 1771
Query: 2274 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 2333
QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL
Sbjct: 1772 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 1831
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE
Sbjct: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC
Sbjct: 1892 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 1951
Query: 2454 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD 2513
EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD
Sbjct: 1952 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD 2011
Query: 2514 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2573
HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK
Sbjct: 2012 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2071
Query: 2574 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2633
QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV
Sbjct: 2072 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2131
Query: 2634 SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF 2693
SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF
Sbjct: 2132 SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF 2191
Query: 2694 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER 2753
QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER
Sbjct: 2192 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKER 2251
Query: 2754 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS 2813
EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS
Sbjct: 2252 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS 2311
Query: 2814 KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD 2873
KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD
Sbjct: 2312 KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD 2371
Query: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT
Sbjct: 2372 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
Query: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW 2993
KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW
Sbjct: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW 2491
Query: 2994 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 3053
ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ
Sbjct: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
Query: 3054 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS 3113
QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS
Sbjct: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS 2611
Query: 3114 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 3173
RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL
Sbjct: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671
Query: 3174 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA 3233
EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA
Sbjct: 2672 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA 2731
Query: 3234 STQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVI 3293
STQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVI
Sbjct: 2732 STQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVI 2791
Query: 3294 VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 3353
VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE
Sbjct: 2792 VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 2851
Query: 3354 DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS 3413
DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS
Sbjct: 2852 DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS 2911
Query: 3414 EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL 3473
EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL
Sbjct: 2912 EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL 2971
Query: 3474 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA 3533
EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA
Sbjct: 2972 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA 3031
Query: 3534 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD 3593
EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD
Sbjct: 3032 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD 3091
Query: 3594 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLT 3653
SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLT
Sbjct: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLT 3151
Query: 3654 ERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKM 3713
ERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKM
Sbjct: 3152 ERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKM 3211
Query: 3714 FQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ 3773
FQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ
Sbjct: 3212 FQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ 3271
Query: 3774 LQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRK 3833
LQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRK
Sbjct: 3272 LQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRK 3331
Query: 3834 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893
ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF
Sbjct: 3332 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3391
Query: 3894 HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ
Sbjct: 3392 HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3451
Query: 3954 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 4013
SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL
Sbjct: 3452 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 3511
Query: 4014 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV
Sbjct: 3512 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 3571
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG
Sbjct: 3572 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 3631
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN
Sbjct: 3632 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 3691
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 4253
EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA
Sbjct: 3692 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 3751
Query: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313
QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS
Sbjct: 3752 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 3811
Query: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 4373
ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES
Sbjct: 3812 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 3871
Query: 4374 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 4433
IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ
Sbjct: 3872 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 3931
Query: 4434 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 4493
STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE
Sbjct: 3932 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 3991
Query: 4494 ALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKF 4553
ALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKF
Sbjct: 3992 ALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKF 4051
Query: 4554 WYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA 4613
WYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA
Sbjct: 4052 WYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA 4111
Query: 4614 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673
DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL
Sbjct: 4112 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4171
Query: 4674 DNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4733
DNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD
Sbjct: 4172 DNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4231
Query: 4734 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4793
RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ
Sbjct: 4232 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4291
Query: 4794 RPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAM 4853
RPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAM
Sbjct: 4292 RPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAM 4351
Query: 4854 NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR 4913
NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR
Sbjct: 4352 NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR 4411
Query: 4914 EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4973
EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK
Sbjct: 4412 EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSK 4471
Query: 4974 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA 5033
MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA
Sbjct: 4472 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA 4531
Query: 5034 NEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
NEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA
Sbjct: 4532 NEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 4591
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD 5153
RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD
Sbjct: 4592 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD 4651
Query: 5154 TTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDA 5213
TTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDA
Sbjct: 4652 TTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDA 4711
Query: 5214 LQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELI 5273
LQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELI
Sbjct: 4712 LQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELI 4771
Query: 5274 ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAE 5333
ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAE
Sbjct: 4772 ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAE 4831
Query: 5334 QTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIK 5393
QTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIK
Sbjct: 4832 QTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIK 4891
Query: 5394 HWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI 5453
HWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI
Sbjct: 4892 HWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI 4951
Query: 5454 PQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLS 5513
PQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLS
Sbjct: 4952 PQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLS 5011
Query: 5514 QPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFD 5573
QPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFD
Sbjct: 5012 QPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFD 5071
Query: 5574 VWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIF 5633
VWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIF
Sbjct: 5072 VWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIF 5131
Query: 5634 DRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKY 5693
DRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKY
Sbjct: 5132 DRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKY 5191
Query: 5694 RFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFI 5753
R FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFI
Sbjct: 5192 R------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFI 5245
Query: 5754 LPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIP 5813
LPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIP
Sbjct: 5246 LPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIP 5305
Query: 5814 SSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSR 5873
SSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSR
Sbjct: 5306 SSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSR 5365
Query: 5874 ASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRT 5933
ASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRT
Sbjct: 5366 ASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKTTTASPRT 5425
Query: 5934 PGPKR 5938
PGPKR
Sbjct: 5426 PGPKR 5430
Score = 443 bits (1139), Expect = e-123
Identities = 766/4113 (18%), Positives = 1662/4113 (40%), Gaps = 437/4113 (10%)
Query: 881 NLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLERE----EAVR 936
+L K+ + D E+TV + IS ++ + + +QS+ +R+ A+R
Sbjct: 1031 HLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALR 1090
Query: 937 LLTKQVVDGGIIHHISGMRLSVD------NAFRHGLIGEDLAEKLKRVENLNIHQIFNPE 990
+ ++ + +R +D ++F H L+ NL + ++ +
Sbjct: 1091 IAEQEHTQ----EDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVY 1146
Query: 991 TKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVL 1050
+ L K +D+I R IQ+ + + +S + + LA+ L EA
Sbjct: 1147 GLSTVYLNKLKTVDVIV----RSIQDAELLVKGYEIKLSQEEVVLAD-----LSALEAHW 1197
Query: 1051 SPGMMHGIVD--PENCRIVPYSELVKKCKIDIE-----SGQRYLEVIPFSDIKDGVSDKV 1103
S + H + D +N E + K K+ E + +R L++ + + + ++
Sbjct: 1198 ST-LRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERW 1256
Query: 1104 LTLSQAIQLGKVDFASTLKVL-EAQANTGGIID-----TATGKRLTLASALEEKLVDENM 1157
+ +++ + + S +VL + +A G +I TA + + A + +++ E +
Sbjct: 1257 HRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQL 1316
Query: 1158 VRIIASHQVLNGGIVDI-----FSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQ 1212
+ A + + FS Q T+V+ E +L++ + ++ R
Sbjct: 1317 SQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKA--FVESQQKSPGKRRRM 1374
Query: 1213 IEKQEGI--EVCALQNEFLGKDMLIACN-QTAEMSCNKVEESERLFQVENQSAQEKVKVR 1269
+ + I E L+ + L + + + ++EE E++ + E Q EKVK
Sbjct: 1375 LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKEL 1434
Query: 1270 V----------------------SDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISI 1307
+ +D E+A +++ +E K ++ ++ F++
Sbjct: 1435 LGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLA- 1493
Query: 1308 INPHNLKGKSLGQVS-----LTHPYSE-CDFKLKEVARNNMGNDTNEEQEKAVTKIEIIS 1361
+ H L K Q+S L Y + CD N + Q + + E +
Sbjct: 1494 KHGHKLSEKEKKQISEQLNALNKAYHDLCD---------GSANQLQQLQSQLAHQTEQKT 1544
Query: 1362 HMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVI 1421
KQ +C + E+ + + + G+ QQ ++A K++ + ++
Sbjct: 1545 LQKQQNTC---HQQLEDLCSWVGQAERALAGHQGR-----TTQQDLSALQKNQSDLKD-- 1594
Query: 1422 VEESIRTCKPAFLSEEKLYQETAIRD----EHDSHIKSQPREMTS--------------- 1462
+++ I+ +F T ++D ++ K PRE+T+
Sbjct: 1595 LQDDIQNRATSF--------ATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEAL 1646
Query: 1463 SEKGKEADTEMGFSITFKIE---ESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSL 1519
E+ + A E+ ++T ++ E S + K +DAL + + + G L
Sbjct: 1647 QEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGG----QL 1702
Query: 1520 CLTLKPEENLS-REIACGA--QSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSF 1576
L E LS + GA ++ + + PE L Q KA+ ++ ++F
Sbjct: 1703 LTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR---HQELLSQQQNF 1759
Query: 1577 QGTTRQETNYQDSWVTSKTKETKHQISSS-NECKEK-----SYQEVSFDPARGLKLEEIT 1630
T+ + D + T E + + E KE+ + E + L+ +E+
Sbjct: 1760 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ-DELQ 1818
Query: 1631 VSRPDSKEVR-YLEFSDRK-DLHHQGSKSDDKLCGTLKSEIATQE-------------LT 1675
D KE +LE S+++ + H+G S + L LK + + E ++
Sbjct: 1819 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTIS 1878
Query: 1676 GEKFLEMANPNVAGLEAGSIEDIV-------TQRGSRV------LGSFLPEKLFKGVSQK 1722
G+K L+M N G E I ++V T+R + + LGS L + G +
Sbjct: 1879 GQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHL--NMLLGQYHQ 1936
Query: 1723 ENTGQQNAIISPTVLETSEEKTVSLTVCS---AVKTEKTPQEKLRESPGSEQTPFMTAPE 1779
+ E + EK +S TV S ++ + ++L+E Q P +
Sbjct: 1937 FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQK 1996
Query: 1780 -GKGNGGVNPEPFRATQNV-FTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAEL 1837
+ + EP ++V T L H + L SY SL + K I + L
Sbjct: 1997 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSL-SY-SLAERSSLLQKAIAQSQSVQESL 2054
Query: 1838 QDLLCQAKVLERELK-----DLTTLVSQELECVNQII----------ISQPQEVPAQLLK 1882
+ LL +E+ L+ L++ V QE N + + +E+ + ++
Sbjct: 2055 ESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFME 2114
Query: 1883 ALEK-DAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNK 1941
+ A LQ L+ VS + L Q E K+L Q E L+ ++ NK
Sbjct: 2115 TADSTTAAVLQGKLAEVSQRFEQLCLQ-QQEKESSLKKLLPQAEMFEHLSGKLQQFMENK 2173
Query: 1942 NLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAF---------------- 1985
+ +L S G+ + D+ QQ ++L M +++ LD L
Sbjct: 2174 SRMLAS-GNQPDQDITHF---FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2229
Query: 1986 -------------DIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032
++Q + E +D S Q + L +L R+FQ L++T + +
Sbjct: 2230 HQDRVQNLRKDFTELQKTVKEREKDASSCQ--EQLDEFRKLVRTFQKWLKETEGSIPPTE 2287
Query: 2033 GHLQQMEQEALVK-------------TLQKQQNTCHQQLEDLC-------------SWVG 2066
+ E E ++ TL ++ N LE+L S +
Sbjct: 2288 TSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILP 2347
Query: 2067 QAERALAGHQGRTTQQDLSALQKNQSDL----KDLQDDIQNRATSFATVVKDIEGFMEEN 2122
++ G T +DL+ +Q + SD+ + L + R S ++ +E +E
Sbjct: 2348 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2407
Query: 2123 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKEL-- 2180
+ L + L + E L + ET AQ E +A + L+Q + K + KE
Sbjct: 2408 NSVL--QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
Query: 2181 -----------AENKKKIDALLD--W-----VT-----SVGSSGGQLLTNLPGMEQLSGA 2217
AEN KKI L+ W VT + S L QL
Sbjct: 2466 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPW 2525
Query: 2218 SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH 2277
+EK + G + ++ P L+ Q + ++ +E +++Q ++AQ L G
Sbjct: 2526 LMEKELMMGVLGPLSID--PNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGD 2583
Query: 2278 -NLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERS 2336
+L+ + Q Q + + + + L +++ Q + Q+ LQD L
Sbjct: 2584 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQD-------LSEK 2636
Query: 2337 EKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 2396
+ + S+ T P +K+Q + ++ S L Q + D E S G++
Sbjct: 2637 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCD-ELSVLIGEQ 2695
Query: 2397 PSEIGNLVKDKLKDATERYT----ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 2452
+KD+LK E L + L L QFQ D L+ W+
Sbjct: 2696 ------YLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 2749
Query: 2453 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2512
++ K + +++ LQ QL ++ Q+ L +H E + ++ + P
Sbjct: 2750 KQSQQAK--NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGE 2806
Query: 2513 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG 2572
+ R +Q + +H++ LS A+R S L+ + ++Q Q +E L+ I + + +
Sbjct: 2807 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 2866
Query: 2573 KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAE 2632
+V +L ++ +L + + ++ +++S LE + ++++ + K A
Sbjct: 2867 LRV-TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEK-AG 2924
Query: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML----ASGNQPDQD 2688
++Q + + + Q K SL+++ + F+ +++ +E L A G+
Sbjct: 2925 INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS----- 2979
Query: 2689 ITHFFQQIQELNLE-MEDQQENLDTLEHLVTELSSC--GFALDLCQHQDRVQNLRKDFTE 2745
Q NLE + QQE L LE V L + G D D Q L +
Sbjct: 2980 -----QACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3034
Query: 2746 LQKTVKEREKDASSC------QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEK 2799
Q+ ++ +++ S C E + +F VR E +L+
Sbjct: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVR----------------EMFSQLADLDD 3078
Query: 2800 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2859
+++ + ++ D S + +E++ + L ++I A S+ + +L G+
Sbjct: 3079 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA--SEAECRHMLEEEGT------ 3130
Query: 2860 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919
DL ++ ++ +N + KL RQE L+ L R+E+ +++ + +
Sbjct: 3131 -----LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAA 3185
Query: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAE-LEQNSPKIQKVKEALAGLLVTYPNSQE 2978
EE + T+ E + Q K F E ++ K+Q+V GL+ + +
Sbjct: 3186 EEAEALQWVVG--TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCD 3243
Query: 2979 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 3038
+ + EE+N+RW + R QL+E+ H FQ A L WL + E ++
Sbjct: 3244 VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3303
Query: 3039 GPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQ 3098
P S + ++ AQ Q+ + + + + R+ + L +A G + +++ ++ +L+
Sbjct: 3304 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDML-QAEGGRIAQSAELA-DREKITGQLE 3361
Query: 3099 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEA 3158
S+ +W EL K +R Q++ +V + Q+ E + +S+ + ++L+ + TQ
Sbjct: 3362 SLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK 3421
Query: 3159 VKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLE 3218
++QQ+ + D+E +V +A + LS L + L ++++++ ++
Sbjct: 3422 IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSEIQ 3480
Query: 3219 DLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEE 3278
D + L AL++ + F + E+ WL + + + + K + L Q ++
Sbjct: 3481 DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA 3540
Query: 3279 FQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRL 3338
+ + + + + G++LL GEE +Q +L +K + +++ ++ L
Sbjct: 3541 LNEEIVNRKKNVDQAIKNGQALLKQT-TGEEVLLIQEKLDGIKTRYADITVTSSKALRTL 3599
Query: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSEL-RVTLDPVQLESSLLRSKAMLNEVEKRRS 3397
+ Q A K+Q E+L W+ + + +++ + Q+ R K + EV + R
Sbjct: 3600 EQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRL 3659
Query: 3398 LLEILNSAADILINSSE-ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ 3456
+L+ +N + L+ +G+ + N+ V++ + + ++ QR ++++
Sbjct: 3660 VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE 3719
Query: 3457 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3516
++ V K +L ALG ++ AQ +V +A +D +R+
Sbjct: 3720 QAADAELAWVAETKRKLM---ALGPIRLEQ---DQTTAQLQVQKAF--SIDIIRH----- 3766
Query: 3517 VEDAPDG--SDASQLL-----HQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVR 3569
+D+ D S S++ Q V Q++ + Q+ + ++ + + + V
Sbjct: 3767 -KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 3825
Query: 3570 EMFSQLADLDDELDGMGAI-------GRDTDSLQSQIEDVRLFLNKIHVLKLDIE---AS 3619
+ + +L ++ A+ D + L+ Q E++R I K I+
Sbjct: 3826 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 3885
Query: 3620 EAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG---RVEDFYRK 3676
+ + + EEG + ++ + + ++ E + R L+ + ++ +F+ K
Sbjct: 3886 GPQLKELNPEEGEM----VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK 3941
Query: 3677 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
++ + + + ++ EV+ I + ++D K E ++ LQ + + G+ L
Sbjct: 3942 IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVE-LEKLQPSFEALKRRGEEL 4000
Query: 3737 I---QSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLS 3793
I Q A KD + ++ ++++ W + + +R + + L KF + LL+
Sbjct: 4001 IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLT 4060
Query: 3794 WLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3853
+ DT++++ + + P + ++K Q++ + ++ D ++ ++ G + +
Sbjct: 4061 TIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGET 4120
Query: 3854 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLAN 3913
++ ++ ++ + + W L R ++LED + A Q+ +T + + D+L T KL
Sbjct: 4121 EKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT 4180
Query: 3914 SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ-SLSSLTSPAEQGVLSEKID 3972
PVGT ++ Q+ K + ++ ++ + G+ L T ++ ++ E +
Sbjct: 4181 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLT 4240
Query: 3973 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV 4032
L+ + + ++ + L+ AL F E+++WL E+ L + V
Sbjct: 4241 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV 4300
Query: 4033 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 4092
+ + A H L +++ + V+ K G LL+ + G++ ++ +L+ + + +
Sbjct: 4301 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4360
Query: 4093 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS---GGQSPTG-EQIPQFQQR 4148
+ + + L+ Q A F S E+ L +E +L+ S GG T EQ+ +
Sbjct: 4361 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4420
Query: 4149 QKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVD 4208
+LK + + +LD + LL + ++ V+ +++ +VS + +R
Sbjct: 4421 YSQLKAKEETYNQLLD---KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKS 4477
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
+++ A+ + +++ + + W+ ++ L P L + +Q++ K F+ ++ H
Sbjct: 4478 KLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH 4537
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
+D + EL +++ ++ +++ S+ ++E + + ER L+ A+ Q
Sbjct: 4538 RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQ 4597
Query: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 4388
F E +++L W+E+ + + + D ++++ Q + ++ ++++ +P D ++ G
Sbjct: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG 4657
Query: 4389 PQLKE--LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP 4446
LKE L PE+ + ++ + + + + + +R L+EA+ S Q F D ++
Sbjct: 4658 RALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ---FMDALQA 4714
Query: 4447 MLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRS 4506
+++ L + +L + ++D + + +K EL K + + LKR G ELI S
Sbjct: 4715 LVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS 4774
Query: 4507 QGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
+ ++ +L ++ W+ + + ++ + L+ AE F + LL + +
Sbjct: 4775 RD-----DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE 4829
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
+ + + D ++ ++ + ++ + ++ +G ++ C
Sbjct: 4830 AEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITT 4889
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD--NTVIKLCTMP 4684
++ I + +E + K+ ++LE A+ V + L+ + W+ T +
Sbjct: 4890 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 4949
Query: 4685 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL 4717
P+ +++ VK + E + F E+ ++Q +++++
Sbjct: 4950 PIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982
Score = 408 bits (1049), Expect = e-113
Identities = 680/3536 (19%), Positives = 1405/3536 (39%), Gaps = 339/3536 (9%)
Query: 2060 DLCSWVGQA----ERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDI 2115
+L SWV + ERA G+ + + L Q + +++L ++ +
Sbjct: 591 ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKE--------ARLY 642
Query: 2116 EGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEA---VTSALQQ--- 2169
EG M +N T+ E L + + QY L+E + + L+ V+ A +
Sbjct: 643 EGKMSQNFH-------TSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIW 695
Query: 2170 --ETEKSKAAKELAENKKKIDALLDWVTSVG---SSGGQLLTNLPGMEQLSGASLEKG-A 2223
E E+ + A + ++N I A ++ + + + +L +L SLE A
Sbjct: 696 LNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAEL--LSLENHPA 753
Query: 2224 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 2283
T + Y Q+ Q + MK Q L +Q+ T Q F D E
Sbjct: 754 KQTVEAYSAAVQS------QLQWMK---QLCLCVEQHVKENTAYFQFFSDAR------EL 798
Query: 2284 QQMLQQKLGELKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEKELEN 2342
+ L+ +K +YS S + L+ + Q DE ++ +Q S + RS+ ++
Sbjct: 799 ESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQ- 857
Query: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402
P + +LK S V ++ + + + VL+ + + K S GN
Sbjct: 858 -----LKPRSPDHVLKNTISVKA-VCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGN 911
Query: 2403 ---------LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
L+ KDA E +R+ ++ +HQ + SL +W
Sbjct: 912 EAMVPSVCFLIPPPNKDAIEM-------ASRVEQSYQKVMALWHQLHVNTKSLISWNYLR 964
Query: 2454 EA-------NVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
+ N+EKL S S PG Q+ + L H E + +RD +
Sbjct: 965 KDLDLVQTWNLEKLRS----SAPGECH-------QIMKNLQAHY---EDFLQDSRDSVLF 1010
Query: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYSLA---ERSSLLQKAIAQSQSVQESLESLLQSI 2563
D ++E ++ + FQ L S+ + ++ + I++ ++++ LE Q +
Sbjct: 1011 S---VADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRV 1067
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM-ETADSTT 2622
+ Q+L + + +A ++D+ + +S L+A F+ ++ S++
Sbjct: 1068 VKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSS 1127
Query: 2623 AAVLQGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679
L+ +L + ++ + L K ++ ++ + E L + + + +L
Sbjct: 1128 VPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVL 1187
Query: 2680 ASGNQPD---QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFA--LDLCQHQD 2734
A + + + H+ +++ N E + + + ++S LDL ++Q+
Sbjct: 1188 ADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQE 1247
Query: 2735 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKET--EGSIPPTETSM 2792
+ L++ + + ++ R+ + S QE L ++R T KW++ET + + +
Sbjct: 1248 KGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAE 1307
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVG 2852
++ L +Q+ +L + T +++ ++ + K + + S
Sbjct: 1308 DSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK--AFVESQQ 1365
Query: 2853 SSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
S G + D I + D+ +Y L + + + + L R+EE K
Sbjct: 1366 KSPGKRRRMLSSSD--AITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEE 1423
Query: 2913 LQ-WLESKEEVLKSMDAMSSPTK----TETVKAQAESNKAFLAE---LEQNSPKIQKVKE 2964
Q +E +E+L + ++ T+ + K + KA L + E+ + K ++V E
Sbjct: 1424 KQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSE 1483
Query: 2965 ALAG---LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLA------ 3015
A+ L + + + K+I E+LN+ + ++ QL++ S LA
Sbjct: 1484 AIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQK 1543
Query: 3016 --------CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ--VQFMLKEFEAR 3065
C Q E L W+ + E + + ++ QK Q ++ + + + R
Sbjct: 1544 TLQKQQNTCHQQLE-DLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 1602
Query: 3066 RQQHEQLNEAAQGILTGPGDVSLSTSQ---VQKELQSINQKWVELTDKLNSRSSQIDQAI 3122
+ + +G + LS + ++++L +++ L ++ ++++A+
Sbjct: 1603 ATSFATVVKDIEGFME-ENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAV 1661
Query: 3123 V--------KSTQYQELLQD------LSEKVRAVG-------------QRLSVQS----- 3150
KS +EL ++ L + V +VG ++LS S
Sbjct: 1662 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 1721
Query: 3151 --------AISTQPEAVKQQLE----ETSEIRSDLEQLDHEVKEAQTLCDELSVLI---G 3195
++ PE + +Q E E+ S + + AQ D+ +
Sbjct: 1722 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 1781
Query: 3196 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 3255
+Q L+ +L + E + L E + ++Q Q+F Q E +WL+ + +
Sbjct: 1782 QQMLQQKLGELKEQYSTSLAQSE----AELKQVQTLQDELQKFLQDHKEFESWLERSEKE 1837
Query: 3256 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-------LSVPPGE 3308
+ E L S L+ F + + H G + G+ +L P E
Sbjct: 1838 LENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSE 1897
Query: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368
++++L + + L K S L + + ++Q + L W++ C+A + +
Sbjct: 1898 IGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEK 1957
Query: 3369 L---RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAA-DILINSSE--ADEDGIRD 3422
L V DP L+ L +K + E+ + + +E L A DI+ E D +++
Sbjct: 1958 LLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE 2017
Query: 3423 EKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQ 3482
I + +++ L ++ L++ + + QES +++ + + + LE G Q
Sbjct: 2018 TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLE-----GKQ 2072
Query: 3483 ACSNKN---LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQE 3539
S + E L ++ Q + Q L T+ +V + +D++ A V Q +
Sbjct: 2073 VSSLSSGVIQEALATNMKLKQDIARQKSSL-EATREMVTRFMETADST----TAAVLQGK 2127
Query: 3540 FLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA----DLDDELDGMGAIGRDTDSL 3595
EV QR C+ + K + + + EMF L+ + M A G D
Sbjct: 2128 LAEVSQRFEQLCLQQQEKESSLKKLLPQA-EMFEHLSGKLQQFMENKSRMLASGNQPD-- 2184
Query: 3596 QSQIEDVRLFLNKIHVLKLDIEASEAE---CRHMLEEEGT----LDLLGLKRELEALNKQ 3648
+D+ F +I L L++E + H++ E + LDL + ++ L K
Sbjct: 2185 ----QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2240
Query: 3649 CGKLTERGKAR-------QEQLELTLGRVEDFYRKLK---GLNDATTAAEEAEALQ---- 3694
+L + K R QEQL+ V F + LK G T + A+ L+
Sbjct: 2241 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2300
Query: 3695 --------WV-VGTEVEIINQQLADFKMFQKEQVDP-LQMKLQQV---NGLGQGLIQSAG 3741
W GT VE IN + + E P Q K + G G +
Sbjct: 2301 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2360
Query: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEEL 3801
D+ ++ DM ++N ++ L + +R LQ L + +L WL EE+
Sbjct: 2361 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2420
Query: 3802 IANQKPPSAEYK--VVKAQIQEQKLLQRLLDDRKATVDML-QAEGGRIAQSAELADREKI 3858
+ + S+ K VKAQ + K L+ + + +A G + + E
Sbjct: 2421 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2480
Query: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
E L SRW ARQ+QLE+ F + +L E + P+
Sbjct: 2481 KKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS 2540
Query: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGV----LSEKIDSL 3974
+ Q + + + ++ E Q + Q + LT P + + + +++ S+
Sbjct: 2541 IDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGI--LTGPGDVSLSTSQVQKELQSI 2598
Query: 3975 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLH 4034
++ E+ D+ +++ +DQA+ + + E ++ + V +LS + + +
Sbjct: 2599 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVK 2658
Query: 4035 RQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTTGEEVLL--IQEKLDGIKTRYAD 4089
+Q L EI + + +D +K Q L L GE+ L ++++L+ +
Sbjct: 2659 QQ----LEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQG 2714
Query: 4090 ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQ 4149
+ ++ + L+ A +FQ ++EL WL + + + A + S E++ Q
Sbjct: 2715 LEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQEN 2774
Query: 4150 KELKKEVMEHRLVLDT-VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVD 4208
+E +K + +H + V E LL + P + L + + ++ +S R
Sbjct: 2775 EEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 2834
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
+ +Q++Q+Y+ + + W+ + K K+ L + L+ Q + L KA ++ +
Sbjct: 2835 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSEL-RVTLDPVQLESSLLRSKAM-LNEVEK 2892
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
+ S+ E+ + ++I E + ++++ + Q +A++ + LE + +
Sbjct: 2893 RRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLRE 2952
Query: 4329 FWETYEELSPWIEETR---ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL 4385
F E+++ + +E + + L S A ++ L E++R +E + +P +D L
Sbjct: 2953 FQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL----EKLRAQQEVLQALEPQVDYLR 3008
Query: 4386 KIGPQLKELNPEEGEMVEEKYQK--AENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK 4443
L E P+ + + +Q A+ + ++K+ V + ++ + I +FH +
Sbjct: 3009 NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLE---GIGQFHCR 3065
Query: 4444 IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4503
+ M L +L L I + D ++ I D + ++ L+ EA + ++
Sbjct: 3066 VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHML 3125
Query: 4504 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4563
D +E++ Q E KAR E+ E+ L E F+ + L
Sbjct: 3126 EEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLEL----TLGRVEDFYRKLKGLNDA 3181
Query: 4564 IKDTQDIVHDLESPGIDPSIIKQQVEAAETI-KEETDGLHEELEFIRILGADLIFACG-E 4621
++ G + II QQ+ + KE+ D L +L+ + LG LI + G +
Sbjct: 3182 TTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKD 3241
Query: 4622 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4681
+ + ++E+N W LNK +R+ +L++A+ ++QD L+ + WL +T +
Sbjct: 3242 CDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3301
Query: 4682 TMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPL 4741
P + VK Q+ E K + + ++ ++ L +G + + A + DR+ I L
Sbjct: 3302 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSA-ELADREKITGQL 3360
Query: 4742 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4801
L+ W L K A RQ +LE L+ QF E + +L+ TE+ L P+
Sbjct: 3361 ESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3420
Query: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861
I+ ++ +H L+ D+ H V K G L ++ + L +++++ + +
Sbjct: 3421 KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQ 3480
Query: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921
+ + L L A+ F + + L L +E +LS+ + Q H+
Sbjct: 3481 DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA 3540
Query: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEE---RK 4978
L ++ +++ +Q + G+ +L T + V L+++K + ++ +
Sbjct: 3541 LNEEIVNRKKNVDQAIKNGQALL--------KQTTGEEVLLIQEKLDGIKTRYADITVTS 3592
Query: 4979 SK----LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
SK LE+A LAT+FQ++ +E WL E+ L + S + + K
Sbjct: 3593 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKK 3652
Query: 5035 EVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 5094
EV HR + +++ L L + + L+ +++ V +R +D A
Sbjct: 3653 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 3712
Query: 5095 KRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDT 5154
+R++Q+ +A + W+ + + L + I + D+ QL K F + + D
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 3772
Query: 5155 TIRTGRAL------KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSG 5208
+ ++KT+L E ++ L +++ + + ER +LE A +
Sbjct: 3773 LFSHRSEIFGTCGEEQKTVLQEKTESL-------IQQYEAISLLNSERYARLERAQVLVN 3825
Query: 5209 QFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRS 5268
QF + + L W+ + +A+ D + + + + ++ + + + L +
Sbjct: 3826 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 3885
Query: 5269 GRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQA---EVFRDTVHML 5325
G +L E + ++ V+ + Q+ + + + + L++A+ Q+ F D + +
Sbjct: 3886 GPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
Query: 5326 LEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL 5381
LE L LR +P + + ++ I +K ++E+ + + GE ++
Sbjct: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4001
Score = 40.4 bits (93), Expect = 0.053
Identities = 137/770 (17%), Positives = 302/770 (39%), Gaps = 89/770 (11%)
Query: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGF----HSEIED 4887
NE E D S S + A + + + EE++ +S A+ H +
Sbjct: 697 NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQT 756
Query: 4888 FLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR 4947
++SQL K E ++ + + +S + E L D + S
Sbjct: 757 VEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKY-SC 815
Query: 4948 DDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ 5007
D + S S+ E ++ M+E++ ++ ++A+ S T+ +
Sbjct: 816 DHNTSLSRLED----------LLQDSMDEKEQLIQSKSSVASLVGRSK-------TIVQ- 857
Query: 5008 SLNIASPPSLILNTV-LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
L SP ++ NT+ + + +++ + + + ++E + + K +S + ++
Sbjct: 858 -LKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVP 916
Query: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
++ + + ++ + +S Q H K LI W ++L +L++
Sbjct: 917 SVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISW-----NYLRKDLDLVQ 971
Query: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLP-EDSQKLDNFLGEVRDK 5185
+ KL+ S E + + Q Y+ ++ R + L D +L+ + + +
Sbjct: 972 TWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSR---DSVLFSVADRLRLEEEVEACKAR 1028
Query: 5186 WDTVCGKSVERQHKLEE-ALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMN- 5243
+ + KS+E + K E A ++ + + L ++ +V ++ D D +
Sbjct: 1029 FQHLM-KSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDN 1087
Query: 5244 --LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTT--WVKGQLQELSTRWDTVCK 5299
+ + Q++L + + + + S ++ ++ +L L + D V
Sbjct: 1088 ALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYG 1147
Query: 5300 LSVSKQSRLEQALKQAEVFRDTVHMLLEW---LSEAEQTLRFRGALPDDTEALQSLIDTH 5356
LS ++L+ +D ++ + LS+ E L D AL++ T
Sbjct: 1148 LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLA-------DLSALEAHWSTL 1200
Query: 5357 KEFMKKVEEKRVDVNSAVAM--GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 5414
+ ++ V++K NS ++ E+ A + ++ + + R++E + ++
Sbjct: 1201 RHWLSDVKDK----NSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERW 1256
Query: 5415 QR----LETALSELVANAELLEELLAW----IQWAETTLIQR---------DQEPIPQNI 5457
R LE SEL + E+L + A I+W E T Q+ D + + +
Sbjct: 1257 HRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQL 1316
Query: 5458 DRVKALIAE---HQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIE-KSRSGGRKSLS 5513
+ AL AE +QT +++ + + K Y+ + + T+ F+E + +S G++
Sbjct: 1317 SQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLM--TYKAFVESQQKSPGKRRR- 1373
Query: 5514 QPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE 5563
+LS S+A L R+ + L + + ++DAL RLEE
Sbjct: 1374 --------MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE 1415
Score = 39.7 bits (91), Expect = 0.090
Identities = 37/140 (26%), Positives = 63/140 (45%), Gaps = 29/140 (20%)
Query: 5431 LEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME-EMTRKQPDVDRVTKTYK 5489
++ L+ WI+ + T++ D+ PQN +KAL ++ F E E+ K+ + R+ + YK
Sbjct: 323 VDSLIPWIK--QHTILMSDKT-FPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYK 379
Query: 5490 RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALE 5549
+E GR L Q P N + W ++ + LE
Sbjct: 380 ----------LLEVWIEFGRIKLPQGYHP---------------NDVEEEWGKLIIEMLE 414
Query: 5550 RQRKLNDALDRLEELKEFAN 5569
R++ L A++RLE L + AN
Sbjct: 415 REKSLRPAVERLELLLQIAN 434
Score = 39.7 bits (91), Expect = 0.090
Identities = 95/472 (20%), Positives = 177/472 (37%), Gaps = 90/472 (19%)
Query: 5069 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDP 5128
L +++ R E+ QR ++R +SL +R +AW+ + + E + ++ +D
Sbjct: 1053 LKNIRLRLEEYEQRVVKRIQSLASSRTD----RDAWQDNALRIAEQEHTQEDLQQLRSDL 1108
Query: 5129 DKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDT 5188
D + ++ Q +++ T R+ E LL E K D
Sbjct: 1109 DAVSMKCDSFLH--------QSPSSSSVPTLRS--ELNLLVE--------------KMDH 1144
Query: 5189 VCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV------- 5241
V G S +KL+ + DA + + E +L++++ V DL +
Sbjct: 1145 VYGLSTVYLNKLKTVDVIVRSIQDAELLVKGY----EIKLSQEEVVLADLSALEAHWSTL 1200
Query: 5242 ----MNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 5297
++ D + VF L + +V+ L D + + +L RW V
Sbjct: 1201 RHWLSDVKDKNSVFSV-LDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRV 1259
Query: 5298 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE--AEQTLRFRGALPD----------- 5344
+QS LE + +R L++W+ E A+Q + G D
Sbjct: 1260 IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQ 1319
Query: 5345 -----DTEALQSLIDTHKEFMKK----VEEKRVDVNSAVAM--------GEVILAVCHPD 5387
+ E Q+ +D ++F ++ V++ + + + A G+ + D
Sbjct: 1320 TALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSD 1379
Query: 5388 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLE-----------ELLA 5436
IT +R R+ ++T QH + + AL L +++E ELL
Sbjct: 1380 AIT---QEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLG 1436
Query: 5437 WIQ-WAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKT 5487
W+ A T + ++ D KA++ E Q EE+T K+ V KT
Sbjct: 1437 WVSTLARNTQGKATSSETKESTDIEKAIL-EQQVLSEELTTKKEQVSEAIKT 1487
Score = 38.9 bits (89), Expect = 0.15
Identities = 34/140 (24%), Positives = 59/140 (42%), Gaps = 12/140 (8%)
Query: 3346 QKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQL-----------ESSLLRSKAMLNEVEK 3394
Q+YQ V+ L+PWI+ MS+ +PV+L E+ +L + +E+
Sbjct: 317 QEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEE 376
Query: 3395 RRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLRE 3454
LLE+ I + D + +E + M + L+ LE + Q +
Sbjct: 377 LYKLLEVWIEFGRIKLPQGYHPND-VEEEWGKLIIEMLEREKSLRPAVERLELLLQIANK 435
Query: 3455 FQESFKNIEKKVEGAKHQLE 3474
Q N E+K+ AK+ L+
Sbjct: 436 IQNGALNCEEKLTLAKNTLQ 455
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 4237 bits (10988), Expect = 0.0
Identities = 2190/4089 (53%), Positives = 2948/4089 (72%), Gaps = 96/4089 (2%)
Query: 1905 RLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQ 1964
RL + ++E EK +H + + ++L+ WV N + L + + +
Sbjct: 1456 RLEEEEKSLEEEK----KEHVE---KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1508
Query: 1965 QYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQT 2024
+ ++ +K QL IQ F+++H ++ ++ ++ + + LQ S+ + ++
Sbjct: 1509 E-------ISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1561
Query: 2025 AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 2084
Q+ Q +E +V Q++ ++L+ +C + Q E L GHQ D
Sbjct: 1562 LKQLQESQTSGDVKVEEKIVAERQQEYK---EKLQGICDLLTQTENRLIGHQEAFMIGDG 1618
Query: 2085 SA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE 2143
+ L+K QS ++LQ D+Q A + A VVK+ E F++EN KLS + + +KL++AK
Sbjct: 1619 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1678
Query: 2144 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 2203
+ E L + ++KEL++ VT+A+++ETEK A K+L E+K KI+ LLDW+++V +
Sbjct: 1679 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1738
Query: 2204 LLTNLPGMEQLSGASLEKG---------------ALDT-TDGYMGVNQAPEKLDKQCEMM 2247
T + + +G ++G L+T DG +G Q E L++Q + +
Sbjct: 1739 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKV 1796
Query: 2248 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 2307
KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ LQ+ + ELK Y T+LA+SE
Sbjct: 1797 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1856
Query: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV 2367
++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G L + LKRQ SFSEDV
Sbjct: 1857 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1916
Query: 2368 ISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNLVKDKLKDATERYTALHSKCT 2423
ISHKGDLR++TISG +VL+ S + GK + S V+ KL AT+R+ +L+SKC
Sbjct: 1917 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1976
Query: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
LG++L L+ +Y +++++ L A +QACEA K LS+ +A DP LQ QL TK LQ
Sbjct: 1977 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2036
Query: 2484 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2543
+++ QV VEKL+K A +++ G P +Q+T D I+ ++ LS S+ ER+ LQ
Sbjct: 2037 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2096
Query: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603
+ +S SVQ+ L+ +L +G VE +L+ + L+S +Q+ ++ N+ L+QDIA ++SS
Sbjct: 2097 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2156
Query: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663
+ A E V +FMET D +TA+ LQ K+ ++S RF + + +E + +++L + E+FE+
Sbjct: 2157 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2216
Query: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC 2723
LS KLQ F+E K++ L + P +D+T Q +QE E + +++L+ L L+ E+SS
Sbjct: 2217 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH 2276
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G D ++ NL K F E++ T+KE+++ +SCQEQLD F+ LV++ + W+KET
Sbjct: 2277 GLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTK 2336
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD---S 2840
+P + S A++L K +E K L + W+ K ++++N G SL NLI +T P +
Sbjct: 2337 KVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA 2396
Query: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900
K+G + + + + + K LT I+ DM+D++ YE LG +L ++ L L+
Sbjct: 2397 AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS 2456
Query: 2901 RMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQ 2960
++++ +E+++++QWL+ + +PT TE VK Q E NK+F AEL+QN K+Q
Sbjct: 2457 KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2516
Query: 2961 KVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020
++K+ L LL P++ EA WK++ E++S+W+ ++T+ RQ++LEES+++L FQ
Sbjct: 2517 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2576
Query: 3021 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080
E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+EF R+ Q+EQL A QGIL
Sbjct: 2577 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2636
Query: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140
+ PG+ V+++L ++ QKW LT +L+ R IDQAIVKSTQYQ LL+ LS+K+
Sbjct: 2637 SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2696
Query: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
+ +LS A+ST P+A+ QQLE +++ +++Q ++K AQ LC++LS L+ E+YLK
Sbjct: 2697 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2756
Query: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
EL ++LE + + +E A + + LQ+A AS+ QFQQM + + WLD K+ +Q K+
Sbjct: 2757 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2816
Query: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
PISAKL+ L+S ++++++F K+L S YE +AEGE+LLL G EK LQ QL +
Sbjct: 2817 PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ-GSEKAALQLQLNTI 2875
Query: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380
K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+ C+ + E++ LDP + E+
Sbjct: 2876 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 2935
Query: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440
S+ + K++ E+++ ++E+LN+ A+ L++ E D++ + DE + Q +D VTE+L +
Sbjct: 2936 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2995
Query: 3441 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 3500
K LE MTQ+ +EFQE K +++++ AK QL+I D+LGSQA SNK L L+ QQ+ LQ
Sbjct: 2996 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3055
Query: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560
AL+ QVD + Q LV +A D S +L Q E QE + Q+V+ C +E KL+G
Sbjct: 3056 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3115
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
IG F +REMFSQ A+ DDELD M +GRD ++LQ Q E ++ FL K+ L + +
Sbjct: 3116 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN 3175
Query: 3621 AECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679
C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR+EQ+E T+ R+E+FY KLK
Sbjct: 3176 KTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE 3235
Query: 3680 LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3739
+ AEE E Q VG E E INQQL FK+FQKE+++PLQ K Q VN LGQGLIQS
Sbjct: 3236 FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQS 3295
Query: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
A K QGLEHD++++NARW TLNKKVAQR AQLQEALLHCG+FQDALE LLSW+ DTE
Sbjct: 3296 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3355
Query: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
EL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV++++ EG +IA +AE AD+ KI
Sbjct: 3356 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3415
Query: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919
QL L+SRW LL+KA R +QLE I V+A+QFHET EP++++L+ EK+L N EP+GT
Sbjct: 3416 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT 3475
Query: 3920 QTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979
Q +K+++QI +HKALE+DI NH +HQAV IGQSL L+S ++ ++ K+D Q Y
Sbjct: 3476 QASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI 3535
Query: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DKLS + V+D+ + L +Q ++
Sbjct: 3536 EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE 3595
Query: 4040 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR 4099
L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+KL+ IK RY DIT S+ +
Sbjct: 3596 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655
Query: 4100 TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEH 4159
TLEQA QLA + ST+EEL WL +VE EL + Q GE+ Q Q R KELKKE +
Sbjct: 3656 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3715
Query: 4160 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
+ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ
Sbjct: 3716 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3775
Query: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK F+++I+RHKD +D+L
Sbjct: 3776 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3835
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
+I C EE+K +++K + +++ Y+ I +NSERY +LERAQ LVNQFWETYEEL PW
Sbjct: 3836 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3895
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 4399
+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKPHIDK+ K GPQL EL+P EG
Sbjct: 3896 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3955
Query: 4400 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLR 4459
++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ FHDKI+ +LE+LE + RLR
Sbjct: 3956 FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ---FHDKIDQILESLERIVERLR 4012
Query: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4519
PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RGEE+I RS G DKD++AK +Q
Sbjct: 4013 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072
Query: 4520 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI 4579
DKLDQMVF WE+I EERE K LDV+ELAEKFW D +L+ TIKDTQD + DLE PGI
Sbjct: 4073 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4132
Query: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639
DPS++KQQ EAAETI+EE DGL EEL+ + LG++LI ACGE +KP V+KSIDE+N+AW+
Sbjct: 4133 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4192
Query: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699
+LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D KL +M P+GTDL TVK Q+ E
Sbjct: 4193 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4252
Query: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++PL ELK +W++L E+I +RQ
Sbjct: 4253 LKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQ 4312
Query: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
HKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GDPK IE+ELAKHHVL+NDVLA
Sbjct: 4313 HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLA 4372
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
HQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++VL+KTE+R+QQL L+QA+
Sbjct: 4373 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4432
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
GFH EIED LT E L ASKP GGLPETA+EQL+ HME+ + +AKEETY L+ K
Sbjct: 4433 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4492
Query: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFI 4999
G+ M L+R + + +Q + L++KW V +K+ ERK+KLEEALNLA EF NSLQ+FI
Sbjct: 4493 GQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4551
Query: 5000 NWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQK 5059
NWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+HR+QIIELD+TG LK+ SQK
Sbjct: 4552 NWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQK 4611
Query: 5060 QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD 5119
QDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQFHEAW KL++WLE++E LD
Sbjct: 4612 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4671
Query: 5120 SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179
SELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTGR+LKEKT L +D+ KLD+ L
Sbjct: 4672 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDML 4731
Query: 5180 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 5239
E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+DWLY+VEPQLAEDQPVHGD+D
Sbjct: 4732 SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID 4791
Query: 5240 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 5299
LVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD++WVK Q+QELSTRW+TVC
Sbjct: 4792 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4851
Query: 5300 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 5359
LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF G LPDD +AL++LID HKEF
Sbjct: 4852 LSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF 4911
Query: 5360 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
MKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITIIRARFEEVL WAKQHQQRL +
Sbjct: 4912 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4971
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+ VKALIAEHQTFMEEMTRKQP
Sbjct: 4972 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5031
Query: 5480 DVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQ 5535
DVD+VTKTYKR+ +P +H P ++K R+ GRK + P +Q E KNPR+N
Sbjct: 5032 DVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPASSLYPSGSQTQIETKNPRVNL 5090
Query: 5536 LSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFR 5595
L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+WRKKYMRWMNHKKSRVMDFFR
Sbjct: 5091 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5150
Query: 5596 RIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD 5655
RIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 5151 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5210
Query: 5656 AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRS 5715
AY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 5211 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5270
Query: 5716 TVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPS 5775
TVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL +GASQGM FR RGRRS+PS
Sbjct: 5271 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5330
Query: 5776 SRAASPTRSSSSASQSNHSCTSMPSSPAT------------------------------- 5804
SR ASP RS+S +SQ+ + + P PAT
Sbjct: 5331 SRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAE 5388
Query: 5805 ----PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSAS 5860
P + P GSKL+ P + S + +G+ S + A+ +T AD KK+ S
Sbjct: 5389 CSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPS 5446
Query: 5861 RPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS---ESSAAGGQGNSRRGLNKPS 5917
RPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD ++ + SR KPS
Sbjct: 5447 RPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPS 5506
Query: 5918 KIPTMSKKT 5926
KIPT +K+
Sbjct: 5507 KIPTPQRKS 5515
Score = 716 bits (1847), Expect = 0.0
Identities = 792/3865 (20%), Positives = 1615/3865 (41%), Gaps = 324/3865 (8%)
Query: 1812 SYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIIS 1871
+Y+ L+ + + K Q E + + LC+ + + + ++ L+S + +++
Sbjct: 1195 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV--- 1251
Query: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV---LNQHTQLE 1928
+ Q+ ALE + + + + T+ R L F E V N H Q++
Sbjct: 1252 ---DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1308
Query: 1929 GRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQ 1988
RL+DL + + L+ Y D P+ + Q++ IQ
Sbjct: 1309 NRLRDL----------------------EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1346
Query: 1989 FFISEHAQDLSPQQNRQ-MLRLLNELQRSFQDILEQTAAQVDAL--QGHLQQMEQEALV- 2044
E+++ L+ Q N+Q ML E+++S D ++ A Q A LQ M A+V
Sbjct: 1347 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1406
Query: 2045 ---------KTLQKQQNTCHQQLEDLCSWVGQAERAL------AGHQGRTTQQDLSALQK 2089
+ +Q + Q+ DL + + AG + +++ +L++
Sbjct: 1407 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1466
Query: 2090 NQSDLKDLQDDIQNRATSFATVVKDIE--GFMEENQTKLSPRELTALREKLHQA------ 2141
+ + + ++Q ++ + +KD E G ++ K+S E++ +E+L +A
Sbjct: 1467 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1526
Query: 2142 -----------------KEQYEALQEETRV----AQKELEEAVTSALQQETEKSKAAKEL 2180
++Q + LQE + + K+L+E+ TS + E+ A+
Sbjct: 1527 FLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKIVAERQ 1585
Query: 2181 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 2240
E K+K+ + D +T Q L G ++ A DG + + + K
Sbjct: 1586 QEYKEKLQGICDLLT-------QTENRLIGHQE---------AFMIGDGTVELKKYQSKQ 1629
Query: 2241 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK---EQ 2297
++ + M+ Q L +N + FL ++G L+ E++ +++QKL E K EQ
Sbjct: 1630 EELQKDMQGSAQALAEVVKN-------TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQ 1682
Query: 2298 YSTSLAQSEAELKQVQT--LQDELQKF-----LQDHK----EFESWLERSEKELE---NM 2343
+ QS+ EL +V T +++E +K L++ K WL +K+ E
Sbjct: 1683 LNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTK 1742
Query: 2344 HKG-------------------------------------GSSPETLPSLLKRQGSFSED 2366
HK G++ E L ++ + E
Sbjct: 1743 HKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEK 1802
Query: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
+IS + T S Q +L+ + + +E ++ +K+ LK E A K +L
Sbjct: 1803 IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE-LKVHYETALAESEKKMKL- 1860
Query: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
+ L + +F + W+Q E +E L + A D L +L K E++
Sbjct: 1861 --THSLQEELEKFDADYTEFEHWLQQSEQELENL--EAGADDINGLMTKLKRQKSFSEDV 1916
Query: 2487 AEHQ-------VPVEKLQKVARDIMEIEG---EPAPDHRHVQETTDSILSHFQSLSYSLA 2536
H+ + ++ + A+ + +G + + HR VQ D F+SL
Sbjct: 1917 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1976
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS---SLSSGVIQEALATNMKL 2593
+ L+ + + Q +++ LL + E K +S ++ +Q L L
Sbjct: 1977 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT-ASKHLSEPIAVDPKNLQRQLEETKAL 2035
Query: 2594 KQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSL 2651
+ I+ Q+ ++E ++ ++ S A +Q L ++ R+E L E+ L
Sbjct: 2036 QGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 2095
Query: 2652 KKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED----QQ 2707
+ L ++ + ++ +M N L Q + T Q I N+ +E +Q
Sbjct: 2096 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNST-ALQDIISKNIMLEQDIAGRQ 2154
Query: 2708 ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEF 2767
+++ + V + Q ++++L F+E KE + +++ F
Sbjct: 2155 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2214
Query: 2768 RKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS 2827
L Q +L+ ++ TE + K++ + ++++ ++ +E
Sbjct: 2215 ENLSEKLQTFLETKTQAL--TEVDVPGKDVTELSQYMQESTSEFLEHKKHLE-------V 2265
Query: 2828 LENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGV 2887
L +L+ EI+ S G LPS D + ++++ K++++
Sbjct: 2266 LHSLLKEIS---SHG-----LPS---------------DKALVLEKTNNLSKKFKEMEDT 2302
Query: 2888 LHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKA 2947
+ E++E++ + +++ S+ W+ +E K + + E + E K
Sbjct: 2303 IKEKKEAVTSCQEQLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKK 2359
Query: 2948 FLAELEQNSPKIQKVKE---ALAGLL--VTYPNSQEA-------------------ENW- 2982
+ +P+IQKV +L L+ VT P A E W
Sbjct: 2360 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2419
Query: 2983 -------KKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL--MEKEL 3033
KK +++ +E + + +L S L Q S + WL M K
Sbjct: 2420 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2479
Query: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQV 3093
P D + Q +Q K FEA +Q+ + + LT + + T +
Sbjct: 2480 TKWQQTPAPTDTEAVKTQVEQ----NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2535
Query: 3094 ---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 3150
++ L I+ KW EL R +++++ TQ+Q + L + + +SV
Sbjct: 2536 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2595
Query: 3151 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQ-YLKDELKKRLET 3209
+S P + Q ++ + + + ++ + GE L+ +K++L
Sbjct: 2596 PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2655
Query: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
V L +DR + + A+ + Q+Q + L L D ++ + + +S + +
Sbjct: 2656 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2715
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
QL+ ++ ++ + Q +V A E L V K L QL + ++++ +
Sbjct: 2716 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2775
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAML 3389
K + L+ + ++Q D W++ K + ++ + + SL++
Sbjct: 2776 KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDF 2835
Query: 3390 NEVEKRRSLL--EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEE 3447
++ +S + + + ++L+ + +++ ++ + I N D ++++ + L+E
Sbjct: 2836 SKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2895
Query: 3448 MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVD 3507
++ +++E + + ++ ++ LE A ++ KL++ Q+ + V+
Sbjct: 2896 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 2955
Query: 3508 YLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR 3567
L N L+ D + + + Q+ V ++++S +EN + +F
Sbjct: 2956 LLNNTANSLLSVCE--IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEV 3013
Query: 3568 VREMFSQLADLDDELDGMGAIGRDTDS------LQSQIEDVRLFLNKIHVLK-----LDI 3616
+E QL ++LD ++G S LQ+Q + ++ +++ + K L +
Sbjct: 3014 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVV 3073
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK 3676
EAS++ +GT D+L ++E + ++ L+++ + LE L + F
Sbjct: 3074 EASDS--------KGTSDVL---LQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNT 3122
Query: 3677 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
++ + ++ VG + E + +Q K F K +++ L N + +
Sbjct: 3123 IREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK-KLEALMASNDNANKTCKMM 3181
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796
+ + D+ G++ D+E ++ + N L + R Q++ + +F L+ L
Sbjct: 3182 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQ 3241
Query: 3797 DTEELIANQKPPSAEYKVVKAQIQEQKLLQR----LLDDRKATVDMLQAEGGRIAQSAEL 3852
EE +Q P E + + Q+ K+ Q+ L ++ V+ L G I +A+
Sbjct: 3242 KAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ--GLIQSAAKS 3299
Query: 3853 ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLA 3912
+ + L+ + +RW L K A R QL++ L+ +F + E + ++ TE+ +A
Sbjct: 3300 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3359
Query: 3913 NSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID 3972
N +P + ++ QI K L+ +++ + V + G+ +++ PA++ + +++
Sbjct: 3360 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3419
Query: 3973 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV 4032
L +R+ + ++ + L+ A+ F E + WL +E +L + +
Sbjct: 3420 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3479
Query: 4033 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 4092
L Q A H AL ++I+N K++ QA+ GQ+L ++ E+ ++Q KLD + Y +I
Sbjct: 3480 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539
Query: 4093 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKEL 4152
S L+QA A F EL WL EV ++L+ Q + E + + Q + L
Sbjct: 3540 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3599
Query: 4153 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGL----DKLVSDANEQYKLVSDTIGQRVD 4208
+++++ L V++ LEL+ + + DKL + +YK ++
Sbjct: 3600 QEDIL---LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA-IKARYKDITKLSTDVAK 3655
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
++ A+Q +++ + W+ + + +L++ L+ ++ + K + +
Sbjct: 3656 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3715
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
K +D L S + + L++ ++Y +S +++ ++ A + Q
Sbjct: 3716 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3775
Query: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 4388
F + + WI ET + L ++ +Q Q + + I HK ID L+K G
Sbjct: 3776 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3835
Query: 4389 PQ-LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ + + EE + +++K K Y I + +R L L+ A S Q E ++++ P
Sbjct: 3836 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3895
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
L +++ S+L P L E + +R+ +++ + + +P + + + G +L+ S
Sbjct: 3896 LTETQSIISQLPAPAL---EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP 3952
Query: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567
G IQ+K + IK ++R + + + + +F + +L +++
Sbjct: 3953 G-----EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4007
Query: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK--- 4624
+ + S + IK+Q+ + + + + L E ++ G ++I G T+K
Sbjct: 4008 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4067
Query: 4625 -PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683
V+ +D+M WEN++ +ER KL D M+ A ++ ++ + +T + +
Sbjct: 4068 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4127
Query: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
G D + VK Q + + E+ Q E++ + + G ++ A E D+ I+++ + E
Sbjct: 4128 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI-AACGEPDKPIVKKSIDE 4186
Query: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
L W++L + R KLE A+ A Q+Q L+ + W+ L + PI D + +
Sbjct: 4187 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4246
Query: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLES-SAGDDASSLRSRLEAMNQCWESVLQ 4862
+ ++ + K++ Q +E +N LL+ + D +++ L + W+S+ +
Sbjct: 4247 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4306
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4922
+ R+ +L+ L F +++ L LT E LS KP GG P+ +L H L
Sbjct: 4307 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4366
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
+ + A + T + ++K L+ S + + +L Q+W V K E+RK +L+
Sbjct: 4367 QNDVLAHQSTV-EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4425
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
AL A F +++ WLT E+ L + P + T Q+ H A +
Sbjct: 4426 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4485
Query: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
L Q G Q+ K I + +++ +WE V + ER L++A A +FH
Sbjct: 4486 YKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4545
Query: 5103 AWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL 5162
+ + I+WL AE L+ S D + Q+ +HK F + + +TG L
Sbjct: 4546 SLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL 4605
Query: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
K + +D + N L V+ +W+ V + VER L++A + QF +A L++WL
Sbjct: 4606 KYFS-QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4664
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS--RDDT 5280
+ E L + + D D + + HK FQK LG + R+GR L E + DD
Sbjct: 4665 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4724
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
+ L EL +WDT+C SV +Q++LE+AL + F D + L++WL E L
Sbjct: 4725 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4784
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
+ D + + +LID HK F K++ ++ V + ++ D + +K + +
Sbjct: 4785 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKVQMQELS 4843
Query: 5401 ARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRV 5460
R+E V + Q RLE AL + ++ LL W+ AE TL R +P + D +
Sbjct: 4844 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTL--RFHGVLPDDEDAL 4901
Query: 5461 KALIAEHQTFMEEMTRKQPDVDRVT 5485
+ LI +H+ FM+++ K+ ++++ T
Sbjct: 4902 RTLIDQHKEFMKKLEEKRAELNKAT 4926
Score = 442 bits (1137), Expect = e-123
Identities = 584/3078 (18%), Positives = 1246/3078 (40%), Gaps = 292/3078 (9%)
Query: 1795 QNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDL 1854
Q TR L ++ + L L + N+E K+ + LN LQD++ + +LE+++
Sbjct: 2096 QITLTRSLSVQ--DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2153
Query: 1855 TTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914
+ ++ E V + + + +L+ K+L S S L +
Sbjct: 2154 QSSINAMNEKVKKFM----ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL-- 2207
Query: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC-LQQY-EDLKQP 1972
KTKV E + L+ ++ K L +E+DV ++ L QY ++
Sbjct: 2208 --KTKV----ELFENLSEKLQTFLETKTQAL------TEVDVPGKDVTELSQYMQESTSE 2255
Query: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032
E K L+ L + E + P +L N L + F++ +E T
Sbjct: 2256 FLEHKKHLEVL----HSLLKEISSHGLPSDKALVLEKTNNLSKKFKE-MEDTI------- 2303
Query: 2033 GHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQS 2092
E++ V + Q+Q + ++ L SW+ + + + Q +DL K+
Sbjct: 2304 -----KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLE 2355
Query: 2093 DLKDLQD----------DIQNRATSFATVVKDI-------------------EGFMEENQ 2123
D K LQ+ + N S ++ + EG +
Sbjct: 2356 DTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2415
Query: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183
+ + LT++++ + YE L + EL + S LQ+ E+S
Sbjct: 2416 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL-SKLQKAQEES--------- 2465
Query: 2184 KKKIDALLDWVTSVGSSGGQ-LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 2242
A++ W+ + + + T P + +E+ + VN+ E DK
Sbjct: 2466 ----SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2521
Query: 2243 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ------QKLGELKE 2296
E+++ T A P +QML Q+L +L
Sbjct: 2522 LTELLEENPD------------TPEA------------PRWKQMLTEIDSKWQELNQLTI 2557
Query: 2297 QYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSL 2356
L +S L Q QT++ +L++ WL E + + P L +
Sbjct: 2558 DRQQKLEESSNNLTQFQTVEAQLKQ----------WLVEKELMVSVLGPLSIDPNMLNTQ 2607
Query: 2357 LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYT 2416
++ ++ + K +T +GQ +L + G++PS + +VK++L T+++
Sbjct: 2608 RQQVQILLQEFATRKPQYEQLTAAGQGILS-----RPGEDPS-LRGIVKEQLAAVTQKWD 2661
Query: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
+L + + ++ + + Q+Q+ SL + + + L+ V++ P + +QL
Sbjct: 2662 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA--VSTHPDAMNQQL 2719
Query: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
T +++++E+ + + ++ Q + D+ + E + + IL F+ +
Sbjct: 2720 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYL-KAELSRQLEGILKSFKDVEQKAE 2778
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
LQ A A S Q+ + ++ S V++ + + +
Sbjct: 2779 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2838
Query: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
+ Q E T + + A LQ +L + ++ Q +E+E+ LK+ L
Sbjct: 2839 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2898
Query: 2657 QA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2712
+A E E L + + N + + + + + +++ L EM+ ++
Sbjct: 2899 KALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE--NSIAKLKSLQKEMDQHFGMVEL 2956
Query: 2713 LEHLVTE-LSSCGFALDLCQHQDR-------------------VQNLRKDFTELQKTVKE 2752
L + LS C ++ +++ ++N+ + F E Q+ KE
Sbjct: 2957 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3016
Query: 2753 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812
++ +EQLD L Q + + + + S+ A L+ Q++ K L D
Sbjct: 3017 SKRQLQCAKEQLDIHDSL--GSQAYSNKYLTMLQTQQKSLQA--LKHQVDLAKRLAQDLV 3072
Query: 2813 -----SKG----------------TLVEEINCKGTSLE----------NLIMEITAP--- 2838
SKG TL ++++ K + LE N I E+ +
Sbjct: 3073 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 3132
Query: 2839 -----DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2893
DS G ++ ++ + K L + + N K K+ E
Sbjct: 3133 FDDELDSMAPVGRDAETLQKQKETIKAF--LKKLEALMASNDNAN-KTCKMMLATEETSP 3189
Query: 2894 SLQAILNRMEEVHKEANSVLQWLESKEE----VLKSMDAMSSPTK--------------- 2934
L I +E + K+ N +L +++EE +K ++ S K
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3249
Query: 2935 -------TETVKAQAESNKAF-LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ 2986
TET+ Q K F E+E K Q V GL+ + S + +
Sbjct: 3250 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 3309
Query: 2987 EELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPN 3046
+++N+RW+ + R QL+E+ H FQ A L W+++ E ++ P S +
Sbjct: 3310 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3369
Query: 3047 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT--GPGDVSLSTSQVQKELQSINQKW 3104
++ AQ Q+ + + + + R+ E + + I T P D ++ K+L ++ +W
Sbjct: 3370 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD----KVKILKQLSLLDSRW 3425
Query: 3105 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 3164
L +K +R+ Q++ V + Q+ E L+ L+E + + +RL I TQ +++Q+
Sbjct: 3426 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3485
Query: 3165 ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADR 3224
+ + D+ + + +A ++ L VL + KD ++ +L+ + +++ + R
Sbjct: 3486 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED-KDMVQSKLDFSQVWYIEIQEKSHSR 3544
Query: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 3284
LQ AL + + F + EL WL++ + +K E L Q E Q+ +
Sbjct: 3545 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3604
Query: 3285 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 3344
+ + + G LL G+E +Q++L +K +++++K + D L+ +Q
Sbjct: 3605 LRKQNVDQALLNGLELLKQT-TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3663
Query: 3345 AQKYQWHVEDLVPWIEDCKAKMSELRV-TLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 3403
A++ E+L W++ + ++ L + + +R K + E + ++LL+ LN
Sbjct: 3664 ARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3723
Query: 3404 SAADILINSSE-ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREF-QESFKN 3461
+ L+ +G+ A N+ V++ + K ++ R ++F Q +
Sbjct: 3724 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3783
Query: 3462 IEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA-QQEVLQALEPQVDYLRNFTQGLVEDA 3520
+ E K + + D Q ++ L+ + E+L+ + D +++ + + A
Sbjct: 3784 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK--IMTA 3841
Query: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
+ + + + + + + Q + + +E + QF E++ L +
Sbjct: 3842 CSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQS 3901
Query: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE---EEGTLDLLG 3637
+ + A + ++L+ Q E+ R I K I+ +LE EG
Sbjct: 3902 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG----FS 3957
Query: 3638 LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV 3697
++ + A + ++ E K R L+ + + F+ K+ + ++ E +
Sbjct: 3958 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 4017
Query: 3698 GTEVEIINQQLADFK--MFQKEQVDPLQMKLQQVNGLGQGLIQSAG---KDCDVQGLEHD 3752
EVE I +Q+++ K E++ PL L+Q G+ +I +G KD + ++
Sbjct: 4018 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQDK 4074
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812
++++ W ++ V +R A+L + + KF L+ + DT++ I + + P +
Sbjct: 4075 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4134
Query: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872
VVK Q + + ++ +D + +D++ G + + D+ + ++ L S W L
Sbjct: 4135 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4194
Query: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI---- 3928
R +LE+ + A Q+ + + + D++ + KLA+ P+GT ++QQI
Sbjct: 4195 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4254
Query: 3929 -IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+ +A ++ IE + HQA + L +T +++ + + + L+ + +++R
Sbjct: 4255 QFKSEAYQQQIEMERLN-HQAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4310
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
+ L+ AL F E+L WL E LS + + A H L ++
Sbjct: 4311 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107
+ + V+ K G L++ + GEE +Q KL+ + R+ ++ + + + L+ A +
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4430
Query: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM----EHRLVL 4163
A F E+L WL + E L S P G +P+ + Q + EV
Sbjct: 4431 AKGFHGEIEDLQQWLTDTERHLLAS---KPLG-GLPETAKEQLNVHMEVCAAFEAKEETY 4486
Query: 4164 DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 4223
++ + + +L P A +D+ +++ E+++ V + +R +++ A+ + ++ +
Sbjct: 4487 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4546
Query: 4224 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF 4283
+ W+ + ++ L L D Q+ K F+ ++ H++ + EL + +
Sbjct: 4547 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4606
Query: 4284 GTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEET 4343
++ +++ S+ ++E + ER L+ A+ QF E + +L W+EE+
Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4666
Query: 4344 RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN--PEEGEM 4401
+ A D ++++ Q + ++ ++S+ D + G LKE ++
Sbjct: 4667 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4726
Query: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
+++ + + + I + +R L+EA+ S Q T D ++ +++ L + +L
Sbjct: 4727 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT---DALQALIDWLYRVEPQLAED 4783
Query: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521
+ ++D + I ++K+ EL K S +ALKR ELI +G+ D + ++Q
Sbjct: 4784 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQ-- 4838
Query: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4581
+ ++ WE + A + ++ + L AE+F + ALL + + + + D
Sbjct: 4839 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 4898
Query: 4582 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4641
++ ++ + ++ + EL +G ++ C ++ I + +E +
Sbjct: 4899 DALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4958
Query: 4642 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD--NTVIKLCTMPPVGTDLNTVKDQLNE 4699
K+ ++L A+ + Q+ L+A+ WL T + + ++ VK + E
Sbjct: 4959 LAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5018
Query: 4700 MKEFKVEVYQQQIEMEKL 4717
+ F E+ ++Q +++K+
Sbjct: 5019 HQTFMEEMTRKQPDVDKV 5036
Score = 404 bits (1039), Expect = e-111
Identities = 676/3612 (18%), Positives = 1415/3612 (39%), Gaps = 437/3612 (12%)
Query: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
++ L+K+ QN +++ +DL +WV + + L RT SDL
Sbjct: 614 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 660
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149
++ ++N + +++ E ++E K+S ++TA EKLH+ + QY L
Sbjct: 661 PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 717
Query: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201
+R ++ L+ V+ A + E E+ + A + +E I D+ +
Sbjct: 718 NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 777
Query: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258
Q N+ +++++ L + A T + Y Q Q C+ ++ +E +
Sbjct: 778 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 837
Query: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317
+ F N E L+ ++ +YS + S +L+ VQ +
Sbjct: 838 EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 881
Query: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368
E ++ LQ + + +++ ++ + P +K + + I
Sbjct: 882 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 941
Query: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421
SH+ + ++ +G + + F KE ++ N ++ + ++ T H
Sbjct: 942 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 997
Query: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480
SH+NM + +H N D ++A + A+++ +L PG Q+ L+ +
Sbjct: 998 -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 1042
Query: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540
E+ E + DI ++E E ++ QE S AER
Sbjct: 1043 SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 1088
Query: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593
Q +SV S +++I +N E + + + + + ++ L ++ KL
Sbjct: 1089 -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1141
Query: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649
K+++ R K L T + F + A S++ L+ +L V Q Q+ +K
Sbjct: 1142 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 1201
Query: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709
++ +L + E L + + + ++A N +I + +++ E++++++
Sbjct: 1202 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 1257
Query: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
LE + + + LD H+++ L + + + + R +D
Sbjct: 1258 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1317
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
+ L +R W+++ E + K E Q E+ K+L + LV E
Sbjct: 1318 GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1369
Query: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874
I K + ++ T D + +T + V S S V I +
Sbjct: 1370 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1429
Query: 2875 SDVNLKYEKL-----------GGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2923
D+ +Y L G L +E +++ +E ++A + +W+ + + L
Sbjct: 1430 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1489
Query: 2924 KSMDAMSSP-------------TKTETVKAQAESNKAFLAEL--EQNSPKIQKVKEALAG 2968
K + P TK E + ++ + FLA+ + + ++++ +
Sbjct: 1490 KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1549
Query: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ------------LEESASHLAC 3016
L +Y N +E+ K++QE S + E VA ++Q L ++ + L
Sbjct: 1550 LQESY-NLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIG 1608
Query: 3017 FQAA-----------ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEAR 3065
Q A + Q + ++K++ + N N K+ + + +E +A
Sbjct: 1609 HQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1668
Query: 3066 RQQH--------EQLNEAAQ-------GILTGPGDVSLSTSQVQKELQSINQK------W 3104
+Q EQLN A+ ++T K+L+ K W
Sbjct: 1669 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1728
Query: 3105 VELTDKLNSRSSQIDQAIVK--STQYQE--LLQDLSEKVRAVGQRL--SVQSAISTQPEA 3158
+ DK + R+ + +++ T +QE + E+ G L V + T E
Sbjct: 1729 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1788
Query: 3159 VKQQLEET----SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 3214
+ QQ ++ +I S + + + AQ L ++ QYL E K++L+ L
Sbjct: 1789 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQG-----QYLSPEEKEKLQKNMKEL 1843
Query: 3215 QGLEDLAADRINRLQAALASTQQFQQMFD----ELRTWLDDKQSQQAKNCPISA-KLERL 3269
+ + A + S Q+ + FD E WL + Q+ +N A + L
Sbjct: 1844 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE-QELENLEAGADDINGL 1902
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS-----------VPPGEEKRTLQNQLV 3318
++L+ + F + + H G I G +L + V R +Q +L
Sbjct: 1903 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1962
Query: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE---LRVTLDP 3375
+ + L K + LKD + K Q Y+ L+ ++ C+A S+ + +DP
Sbjct: 1963 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2022
Query: 3376 VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI----------NSSEADEDGIRDEKA 3425
L+ L +KA+ ++ ++ +E L A++L+ N + D I
Sbjct: 2023 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 2082
Query: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALGSQAC 3484
++++++ E+LQ + L E + N+E + K Q ++ ++ Q
Sbjct: 2083 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL---KEQGQVPLNSTALQDI 2139
Query: 3485 SNKNL---EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL 3541
+KN+ + + +Q + A+ +V T D S AS L + + F
Sbjct: 2140 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETT--------DPSTASSLQAKMKDLSARFS 2191
Query: 3542 EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIED 3601
E + ME + E+F L ++ LQ+ +E
Sbjct: 2192 EASHKHKETLAKMEELKTKV--------ELFENL----------------SEKLQTFLET 2227
Query: 3602 VRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQE 3661
L ++ D+ + +E T + L K+ LE L+ +++ G +
Sbjct: 2228 KTQALTEV-----DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 2282
Query: 3662 QLELTLGRVEDFYRKLKGLND--------ATTAAEEAEALQ--------WVVGTE----- 3700
L L + + +K K + D T+ E+ +A Q W+ T
Sbjct: 2283 --ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI 2340
Query: 3701 ------VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL----------------IQ 3738
E + + L D K Q E+ ++Q+VN G L ++
Sbjct: 2341 VQPSFGAEDLGKSLEDTKKLQ-EKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVK 2399
Query: 3739 SAGKDCDVQG----------------LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
S G + +G ++ DM +I+ + L + +IA+L L
Sbjct: 2400 SGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQ 2459
Query: 3783 KFQDALEPLLSWLADTEELIA--NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
K Q+ ++ WL + Q P + + VK Q+++ K + L V L+
Sbjct: 2460 KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2519
Query: 3841 AE-GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3899
+ + ++ + + + L ++S+W EL RQ++LE+ QF
Sbjct: 2520 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2579
Query: 3900 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL- 3958
+ +L E ++ P+ + Q + + L ++ Q GQ + S
Sbjct: 2580 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRP 2639
Query: 3959 -TSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
P+ +G++ E++ ++ ++ + + + +DQA+ + + + + L++++
Sbjct: 2640 GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLD 2699
Query: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTTGEEVL 4074
+KLSS D +++Q + +EI KK IK QAL L EE L
Sbjct: 2700 NKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQ----IKVAQALCEDLSALVKEEYL 2755
Query: 4075 L--IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+ +L+GI + D+ + ++ L+ A + +FQ + WL +EE S
Sbjct: 2756 KAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKS 2815
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA 4192
S + + + K+ K + + + LL + L ++
Sbjct: 2816 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTI 2875
Query: 4193 NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL----MALGPIRLEQ 4248
+ + + +R +++ +++++ +Y++ + W+ + + L L P E
Sbjct: 2876 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP--AEG 2933
Query: 4249 DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 4308
+ + A+L K+ ++ +H ++ L + + + C E K V+ ++ +SLIQ+ + +
Sbjct: 2934 ENSIAKL---KSLQKEMDQHFGMVELLNNTANSLLSVC-EIDKEVVTDENKSLIQKVDMV 2989
Query: 4309 S-LLNSERYARLERAQVLVNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQ 4364
+ L+S+++ LE +F E +E ++ E + L S A ++ L Q
Sbjct: 2990 TEQLHSKKFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3048
Query: 4365 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
+ + L+ +H+ + K L ++ + + V + + ++ + ++V ++
Sbjct: 3049 TQQKSLQ--ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3106
Query: 4425 LALDEAVS-----QST------QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 4473
L+ + Q+T Q EF D+++ M + + + I A + K+
Sbjct: 3107 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3166
Query: 4474 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4533
++ N +A K A + +L+G + D + +K+ LD
Sbjct: 3167 LMASNDNA----NKTCKMMLATEETSPDLVGIKR--DLEALSKQCNKLLD---------- 3210
Query: 4534 ARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET 4593
RA+ RE + ++ E+F+ + ++ ++ G++ I QQ+ +
Sbjct: 3211 -RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 3269
Query: 4594 I-KEETDGLHEELEFIRILGADLI-FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4651
KEE + L + + + LG LI A T + +D++N W+ LNK +R +
Sbjct: 3270 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 3329
Query: 4652 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4711
L++A+ ++QD L+++ W+ +T + P + VK Q+ E K + + ++
Sbjct: 3330 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRK 3389
Query: 4712 IEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771
+E + +GE + A + D+ I + L+ L WE L K R +LEG + Q
Sbjct: 3390 STVEVIKREGEKIATTA-EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3448
Query: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
F LE L WLT E+ L PI +E ++A+H L++D++ H + G
Sbjct: 3449 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3508
Query: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L S+ +D ++S+L+ + + +K+ R + LQ L A+ F + + +
Sbjct: 3509 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 3568
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + +LS E +Q L + +++ +Q L G L LL +
Sbjct: 3569 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNG-LELLKQTTGD 3627
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
+ + ++ ++ ++ + LE+AL LA ++ +E WL E L +
Sbjct: 3628 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL-L 3686
Query: 5012 ASPPSLILNTVLSQIE-EHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLV 5070
+ ++ SQ + K E ++ + L++ + L L + ++ ++
Sbjct: 3687 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVA 3746
Query: 5071 SVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
R+ V ++ +D A R++QF +A + W+ + E L S +I + D+
Sbjct: 3747 EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3806
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
QL K F + + + D +++G + E+ Q + L +V +DT+C
Sbjct: 3807 TSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM-TACSEEEKQSMKKKLDKVLKNYDTIC 3865
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
+ ER +LE A QF + + L WL + + +++ + + + + H+
Sbjct: 3866 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQ 3925
Query: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
++ + + + + ++G +L+E S + ++ + T + + + + L++
Sbjct: 3926 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 3985
Query: 5311 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
A+ Q+ F D + +LE L + LR ++ + E ++ I +K +E+ +
Sbjct: 3986 AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLY 4045
Query: 5371 NSAVAMGEVILA 5382
+ GE ++A
Sbjct: 4046 ETLKQRGEEMIA 4057
Score = 381 bits (978), Expect = e-104
Identities = 610/3185 (19%), Positives = 1269/3185 (39%), Gaps = 392/3185 (12%)
Query: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
+SSLL + + + + + ++ LL + E++ L+ + S D+
Sbjct: 619 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 660
Query: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2653
+S LE + V R +E +S+ + + K++E+ Q L L EK ES K
Sbjct: 661 PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 715
Query: 2654 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2701
LL + E L F+ + L N+ +++ + + N+
Sbjct: 716 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 775
Query: 2702 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2735
E++ ++EN+ +++ + +L + + L LCQ ++
Sbjct: 776 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 835
Query: 2736 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792
N K+ T+ + +K+ + SC ++ KL Q+ ++E E + T
Sbjct: 836 YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 894
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2848
+ K I LK D K ++ + C +E I + + A +S ++
Sbjct: 895 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 954
Query: 2849 PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2908
G+ + T + D+++ ++ Q +L E H
Sbjct: 955 SPTGNEAMVPSVCFTVPPPNKEAVDLAN-------------RIEQQYQNVLTLWHESHIN 1001
Query: 2909 ANSVLQW--LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL 2966
SV+ W L ++ + +++ + S T Q SN L ++ + + +
Sbjct: 1002 MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN---LQSRFEDFLEDSQESQVF 1058
Query: 2967 AGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 3026
+G +T + + QE L S A + + EES +L + +LR
Sbjct: 1059 SGSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRL 1108
Query: 3027 WLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086
E L+ + PL D + F + E E +++ E+L + G +T +
Sbjct: 1109 ENCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEE 1161
Query: 3087 SLSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL----- 3132
S + + ++ + + +N S+ ID+ ++K+TQ E L
Sbjct: 1162 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 1221
Query: 3133 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 3192
L E+ + + ++++ IST +KQ E E R L+ E+++A+ + DE+
Sbjct: 1222 TKLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 1277
Query: 3193 LIGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 3251
E+ L D K++ + + Q + +R+ L+ S + ++ + L W+
Sbjct: 1278 TYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ- 1336
Query: 3252 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 3311
++E Q ++QEN+ E +
Sbjct: 1337 -------------QVETTQRKIQENQP-----------------------------ENSK 1354
Query: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 3371
TL QL + K E+ K QS++ +C + A++Y V+D +A + +
Sbjct: 1355 TLATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1410
Query: 3372 TLDPVQLESSLLRSKAMLNEVEKRRS--------LLEILNSAADILINSSEADEDGIRDE 3423
+ PV+ + ++ E R+ + + + A D L E +E + +E
Sbjct: 1411 S--PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL-KRLEEEEKSLEEE 1467
Query: 3424 K-------AGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF 3476
K + + + +++ L+ + + + + E ++++ A +++F
Sbjct: 1468 KKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLF 1527
Query: 3477 DALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3536
A +++ +L Q + LQ Y F++ L + + + + VA
Sbjct: 1528 LAKHGDKMTDEERNELEKQVKTLQE-----SYNLLFSESLKQLQESQTSGDVKVEEKIVA 1582
Query: 3537 --QQEFLEVKQRVNSGCVMMENKLEG------IGQFHCRVREMFSQLADLDDELDG---- 3584
QQE+ E Q + EN+L G IG +++ S+ +L ++ G
Sbjct: 1583 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1642
Query: 3585 MGAIGRDTDSLQSQ------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
+ + ++T++ + ED L K++ K+ E + +E + +
Sbjct: 1643 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1702
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVE-DFYR---KLKGL----------NDAT 3684
K E E + K E K + E L L V+ D R K K + D
Sbjct: 1703 KEETEKV--AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGK 1760
Query: 3685 TAAEEAEA---------LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3735
+A E + + VGT E +NQQ K Q E++ + Q
Sbjct: 1761 SAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQSAQV 1819
Query: 3736 LIQSAGKDC---DVQGLEHDMEEINARWNTL---NKKVAQRIAQLQEALLHCGKFQDALE 3789
L++ G+ + + L+ +M+E+ + T ++K + LQE L KF
Sbjct: 1820 LLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---EKFDADYT 1876
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
WL +E+ + N + + + + +++ QK + K + + G R+ ++
Sbjct: 1877 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1936
Query: 3850 AE------------LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA 3897
A+ A ++ +L+ R+ L SK L+D++ + + + +
Sbjct: 1937 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1996
Query: 3898 EPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955
+ L E + SEP+ +Q+Q+ KAL+ I + V + K + L
Sbjct: 1997 CGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 2056
Query: 3956 SSLTS---PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW 4012
PA+ + + +D + RY ++ + L L+ + + E+L+W
Sbjct: 2057 LDARGSLLPAKNDI-QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2115
Query: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
+ VE L L + ++ L ++I R+ +++ + + ++ T
Sbjct: 2116 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPST 2175
Query: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+Q K+ + R+++ + + L +E+ + F++ E+L +L + L
Sbjct: 2176 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE- 2234
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL-VPWRAREGLDKLVSD 4191
G+ + + Q +E E +EH+ L+ ++ + + + +P L+K ++
Sbjct: 2235 --VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNN 2291
Query: 4192 ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-- 4249
++++K + DTI ++ + + + ++ ++ + +W+ ET +K+ + P +D
Sbjct: 2292 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2351
Query: 4250 ---QTTAQLQVQKAFSIDIIRHKD----SMDELFSH------------------RSEIFG 4284
+ T +LQ + + I+ + S+ L S E
Sbjct: 2352 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2411
Query: 4285 TCGEE-----QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
T EE T +++ + YE + LL ++ A L + + E + W
Sbjct: 2412 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2471
Query: 4340 IE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL-- 4394
++ +T Q P+P D E ++ Q E+ + AE K +++K+ ++ +L EL
Sbjct: 2472 LQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFE---AELKQNVNKVQELKDKLTELLE 2527
Query: 4395 -NPEEGEMVEEKYQKAE--NMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
NP+ E K E + + ++ + R L+E+ + TQ +++ L
Sbjct: 2528 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2587
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
E + S L + P ++ R+ + + E +P +E L G+ ++ R G D
Sbjct: 2588 ELMVSVLGPLSIDPNMLNTQRQQV---QILLQEFATRKPQYEQLTAAGQGILSR-PGEDP 2643
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
L ++++L + W+ + + +R + + ++ + +L + D + +
Sbjct: 2644 SLRG-IVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKL 2702
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADL-IFACGETEKPEVRKS 4630
+ P + QQ+E A+ +K+E ++++ + L DL E K E+ +
Sbjct: 2703 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2762
Query: 4631 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL 4690
++ + +++++ + + ++ L+ A ++ Q+Q + WLD + P+ L
Sbjct: 2763 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2822
Query: 4691 NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN 4750
+ ++ + + K+F + Q EK +GE +L K T +++ ++ L +K W+
Sbjct: 2823 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK-TQGSEKAALQLQLNTIKTNWDT 2881
Query: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
+++ R++KL+ +L +++ +E L W+ + L+ + DP E +AK
Sbjct: 2882 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKL 2940
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
L+ ++ H VE +N N LL D E + +S++QK + +Q
Sbjct: 2941 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDK--------EVVTDENKSLIQKVDMVTEQ 2992
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQ----- 4925
L S + + ++F SK + + A+EQLD H L SQ
Sbjct: 2993 LHSKKFCLENMTQKFKEF----------QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 3042
Query: 4926 ----LKAKEETYNQLLDKGRL-------MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKM 4974
L+ ++++ L + L +++ DS S V + Q+ +S ++
Sbjct: 3043 YLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3102
Query: 4975 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
+E+ S LE L FQN+++E + + L+ +P T+ Q E K F
Sbjct: 3103 DEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK 3162
Query: 5035 EVNAHRDQIIELDQTGNQLKFLSQ-KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
++ A ++T + + D+V IK L ++ + K++ R+ R ++
Sbjct: 3163 KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 3222
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK----TLGGKQ 5149
KR ++F+ K+ L+ AE H +S+ + + + I QL+ K FQK L GKQ
Sbjct: 3223 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3282
Query: 5150 PVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
+ G+ L + +Q L++ L +V +W T+ K +R +L+EALL G+
Sbjct: 3283 QDVNW---LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3339
Query: 5210 FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 5269
F DAL++L+ W+ E +A +P + +V + K+ Q+ L R TV+V+KR G
Sbjct: 3340 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3399
Query: 5270 RELIENSRD-DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 5328
++ + D + QL L +RW+ + + ++ +LE A+ F +T+ L EW
Sbjct: 3400 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3459
Query: 5329 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 5388
L+ E+ L + L+ I HK + ++ AV++G+ + + +
Sbjct: 3460 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED 3519
Query: 5389 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI---------- 5438
++ + + + E+ + + L+ AL E EL+ W+
Sbjct: 3520 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKL 3579
Query: 5439 ------------QWAETTLIQRDQEPIPQNIDR--VKALIAEHQTFMEEMTRKQPDVDRV 5484
Q +E ++Q D QN+D+ + L QT +E+ Q ++ +
Sbjct: 3580 SVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 3639
Query: 5485 TKTYK 5489
YK
Sbjct: 3640 KARYK 3644
Score = 60.8 bits (146), Expect = 4e-08
Identities = 181/985 (18%), Positives = 364/985 (36%), Gaps = 178/985 (18%)
Query: 4666 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4723
+Q + +W+D ++L G+DL +V+ L K +E ++ ++ K++
Sbjct: 637 VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 695
Query: 4724 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4783
K T E H E+ K+ + E L L F + WL
Sbjct: 696 APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 744
Query: 4784 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4839
EE ++ D +A+ H L ++ + +++V + +LL +
Sbjct: 745 NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 799
Query: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4894
++ + AM W +LQ + EQ ++ + F+ E D+L L +
Sbjct: 800 -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 858
Query: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4953
+ S L + +E ++ EL + T L+ K + ++ L +S
Sbjct: 859 RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 914
Query: 4954 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4981
KT + + KW V+S E
Sbjct: 915 LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 974
Query: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041
+EA++LA + Q++ N LTL +S + + + NE++ R
Sbjct: 975 KEAVDLANRIE---QQYQNVLTLWHES-----------HINMKSVVSWHYLINEIDRIRA 1020
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKRA 5097
+ +K + + ++ NL QSR+E ++ S E G + K
Sbjct: 1021 SNVA------SIKTMLPGEHQQVLSNL----QSRFEDFLEDSQESQVFSGSDITQLEKEV 1070
Query: 5098 ---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTLG 5146
KQ+++ K + E ES + L + N D++ Q+ E
Sbjct: 1071 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE------ 1124
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ--------- 5197
+ ++++ R + E+ L ++ ++L + LG + +K + ++
Sbjct: 1125 -RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 1179
Query: 5198 ----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVMN 5243
+ + S ++D L+ + + L K+ E +L E++ V D + + N
Sbjct: 1180 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 1239
Query: 5244 LMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELSTR 5293
L+ K ++ E+ ++ L K E+ + ++ D W K + +L R
Sbjct: 1240 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 1299
Query: 5294 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSL 5352
W V ++ LE K + +RDT H L +W+ + E T R + P++++ L +
Sbjct: 1300 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1359
Query: 5353 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQ 5412
++ K + ++E K+ ++ E A + T+ + RA +
Sbjct: 1360 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------- 1407
Query: 5413 HQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 5472
QQ+ + ++A+L+ + ++ T L+ + I D +K L E ++ E
Sbjct: 1408 -QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1466
Query: 5473 EMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5531
E K+ V++ + K NI T ++ + G+ PP SE +
Sbjct: 1467 E---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIST 1512
Query: 5532 RINQLSARWQQVWLLALERQRKLND 5556
+ QLS Q + L + K+ D
Sbjct: 1513 KKEQLSEALQTIQLFLAKHGDKMTD 1537
Score = 51.6 bits (122), Expect = 2e-05
Identities = 138/725 (19%), Positives = 278/725 (38%), Gaps = 93/725 (12%)
Query: 4820 HQATVETVNKAGNELLESS------AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
HQ + + + LE S +G D + L + Q ++ +L+ E RE+Q +S
Sbjct: 1034 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE-REEQEES 1092
Query: 4874 TLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY---SQLKAKE 4930
+ SE+ + L L E +L T E+ D H ++ Q K K+
Sbjct: 1093 VYNL---YISEVRNIRLRLENCEDRLIRQ------IRTPLERDDLHESVFRITEQEKLKK 1143
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE------EA 4984
E +L D + ++ S + SV L + +VV M + S +
Sbjct: 1144 E-LERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT 1202
Query: 4985 LNLATEFQNSLQEFINW--LTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
+NL + + + + L E+ IA N + + I K + +EV+ R
Sbjct: 1203 VNLVLKNTQAAEALVKLYETKLCEEEAVIADK-----NNIENLISTLKQWRSEVDEKRQV 1257
Query: 5043 IIELDQTGNQLKFLSQKQ---------DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
L+ + K +S + D K + RW+ V + R R L+
Sbjct: 1258 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1317
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIK---LQLSKHKEFQKTLGGKQP 5150
K K + + + L DW++ E+ E N P+ K QL++ K + KQ
Sbjct: 1318 GKSLKYYRDTYHPLDDWIQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVSEIEMKQS 1375
Query: 5151 VYDTTIRTGR----ALKEKTL-------LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
D + +K+ L + + QK ++ D + + ++ + +
Sbjct: 1376 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1435
Query: 5200 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 5259
+ Q++ + L + E L E++ H ++ K QK + +
Sbjct: 1436 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH---------VEKAKELQKWVSNIS 1486
Query: 5260 GTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFR 5319
T++ +++G+ + + + + ++LS T+ +L ++K K + R
Sbjct: 1487 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI-QLFLAKHGD-----KMTDEER 1540
Query: 5320 DTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEV 5379
+ + ++ L E+ L +E+L+ L ++ KVEEK V E
Sbjct: 1541 NELEKQVKTLQESYNLL--------FSESLKQLQESQTSGDVKVEEKIV-AERQQEYKEK 1591
Query: 5380 ILAVCHPDCITTIKHWITIIRARF--EEVLTWAKQHQQRLETALSELVANAELLEELLA- 5436
+ +C D +T ++ + + F + K++Q + E ++ +A+ L E++
Sbjct: 1592 LQGIC--DLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKN 1649
Query: 5437 ---WIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI 5493
+++ L Q D+ I Q ++ K + E E ++K ++D+V T ++
Sbjct: 1650 TENFLKENGEKLSQEDKALIEQKLNEAK-IKCEQLNLKAEQSKK--ELDKVVTTAIKEET 1706
Query: 5494 EPTHA 5498
E A
Sbjct: 1707 EKVAA 1711
Score = 40.0 bits (92), Expect = 0.069
Identities = 37/141 (26%), Positives = 63/141 (44%), Gaps = 29/141 (20%)
Query: 5430 LLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME-EMTRKQPDVDRVTKTY 5488
++ L+ WI+ TT+ +R P N +KAL ++ F E E+ K+ + ++ + Y
Sbjct: 308 MVNYLIQWIRHHVTTMSERT---FPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLY 364
Query: 5489 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5548
K I +IE GR L Q P N + W ++ + L
Sbjct: 365 KLLEI------WIEF----GRIKLLQGYHP---------------NDIEKEWGKLIIAML 399
Query: 5549 ERQRKLNDALDRLEELKEFAN 5569
ER++ L ++RLE L++ AN
Sbjct: 400 EREKALRPEVERLEMLQQIAN 420
Score = 39.3 bits (90), Expect = 0.12
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363
K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + +
Sbjct: 619 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 677
Query: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423
EE + A + E+ + T + + +++ ++L ++ ++ L+T L
Sbjct: 678 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 732
Query: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483
V+ A L W+ E + D NI R K H M E+ +K+ ++
Sbjct: 733 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 786
Query: 5484 VTKTYKRKNIE 5494
V + ++ +E
Sbjct: 787 VQEIAEQLLLE 797
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 4237 bits (10988), Expect = 0.0
Identities = 2190/4089 (53%), Positives = 2948/4089 (72%), Gaps = 96/4089 (2%)
Query: 1905 RLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQ 1964
RL + ++E EK +H + + ++L+ WV N + L + + +
Sbjct: 1467 RLEEEEKSLEEEK----KEHVE---KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1519
Query: 1965 QYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQT 2024
+ ++ +K QL IQ F+++H ++ ++ ++ + + LQ S+ + ++
Sbjct: 1520 E-------ISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1572
Query: 2025 AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 2084
Q+ Q +E +V Q++ ++L+ +C + Q E L GHQ D
Sbjct: 1573 LKQLQESQTSGDVKVEEKIVAERQQEYK---EKLQGICDLLTQTENRLIGHQEAFMIGDG 1629
Query: 2085 SA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE 2143
+ L+K QS ++LQ D+Q A + A VVK+ E F++EN KLS + + +KL++AK
Sbjct: 1630 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1689
Query: 2144 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 2203
+ E L + ++KEL++ VT+A+++ETEK A K+L E+K KI+ LLDW+++V +
Sbjct: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1749
Query: 2204 LLTNLPGMEQLSGASLEKG---------------ALDT-TDGYMGVNQAPEKLDKQCEMM 2247
T + + +G ++G L+T DG +G Q E L++Q + +
Sbjct: 1750 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKV 1807
Query: 2248 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 2307
KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ LQ+ + ELK Y T+LA+SE
Sbjct: 1808 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1867
Query: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV 2367
++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G L + LKRQ SFSEDV
Sbjct: 1868 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1927
Query: 2368 ISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNLVKDKLKDATERYTALHSKCT 2423
ISHKGDLR++TISG +VL+ S + GK + S V+ KL AT+R+ +L+SKC
Sbjct: 1928 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1987
Query: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
LG++L L+ +Y +++++ L A +QACEA K LS+ +A DP LQ QL TK LQ
Sbjct: 1988 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2047
Query: 2484 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2543
+++ QV VEKL+K A +++ G P +Q+T D I+ ++ LS S+ ER+ LQ
Sbjct: 2048 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2107
Query: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603
+ +S SVQ+ L+ +L +G VE +L+ + L+S +Q+ ++ N+ L+QDIA ++SS
Sbjct: 2108 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2167
Query: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663
+ A E V +FMET D +TA+ LQ K+ ++S RF + + +E + +++L + E+FE+
Sbjct: 2168 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2227
Query: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC 2723
LS KLQ F+E K++ L + P +D+T Q +QE E + +++L+ L L+ E+SS
Sbjct: 2228 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH 2287
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G D ++ NL K F E++ T+KE+++ +SCQEQLD F+ LV++ + W+KET
Sbjct: 2288 GLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTK 2347
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD---S 2840
+P + S A++L K +E K L + W+ K ++++N G SL NLI +T P +
Sbjct: 2348 KVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA 2407
Query: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900
K+G + + + + + K LT I+ DM+D++ YE LG +L ++ L L+
Sbjct: 2408 AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS 2467
Query: 2901 RMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQ 2960
++++ +E+++++QWL+ + +PT TE VK Q E NK+F AEL+QN K+Q
Sbjct: 2468 KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2527
Query: 2961 KVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020
++K+ L LL P++ EA WK++ E++S+W+ ++T+ RQ++LEES+++L FQ
Sbjct: 2528 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2587
Query: 3021 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080
E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+EF R+ Q+EQL A QGIL
Sbjct: 2588 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2647
Query: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140
+ PG+ V+++L ++ QKW LT +L+ R IDQAIVKSTQYQ LL+ LS+K+
Sbjct: 2648 SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2707
Query: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
+ +LS A+ST P+A+ QQLE +++ +++Q ++K AQ LC++LS L+ E+YLK
Sbjct: 2708 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2767
Query: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
EL ++LE + + +E A + + LQ+A AS+ QFQQM + + WLD K+ +Q K+
Sbjct: 2768 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2827
Query: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
PISAKL+ L+S ++++++F K+L S YE +AEGE+LLL G EK LQ QL +
Sbjct: 2828 PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ-GSEKAALQLQLNTI 2886
Query: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380
K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+ C+ + E++ LDP + E+
Sbjct: 2887 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 2946
Query: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440
S+ + K++ E+++ ++E+LN+ A+ L++ E D++ + DE + Q +D VTE+L +
Sbjct: 2947 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 3006
Query: 3441 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 3500
K LE MTQ+ +EFQE K +++++ AK QL+I D+LGSQA SNK L L+ QQ+ LQ
Sbjct: 3007 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3066
Query: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560
AL+ QVD + Q LV +A D S +L Q E QE + Q+V+ C +E KL+G
Sbjct: 3067 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3126
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
IG F +REMFSQ A+ DDELD M +GRD ++LQ Q E ++ FL K+ L + +
Sbjct: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN 3186
Query: 3621 AECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679
C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR+EQ+E T+ R+E+FY KLK
Sbjct: 3187 KTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE 3246
Query: 3680 LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3739
+ AEE E Q VG E E INQQL FK+FQKE+++PLQ K Q VN LGQGLIQS
Sbjct: 3247 FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQS 3306
Query: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
A K QGLEHD++++NARW TLNKKVAQR AQLQEALLHCG+FQDALE LLSW+ DTE
Sbjct: 3307 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3366
Query: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
EL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV++++ EG +IA +AE AD+ KI
Sbjct: 3367 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3426
Query: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919
QL L+SRW LL+KA R +QLE I V+A+QFHET EP++++L+ EK+L N EP+GT
Sbjct: 3427 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT 3486
Query: 3920 QTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979
Q +K+++QI +HKALE+DI NH +HQAV IGQSL L+S ++ ++ K+D Q Y
Sbjct: 3487 QASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI 3546
Query: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DKLS + V+D+ + L +Q ++
Sbjct: 3547 EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE 3606
Query: 4040 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR 4099
L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+KL+ IK RY DIT S+ +
Sbjct: 3607 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
Query: 4100 TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEH 4159
TLEQA QLA + ST+EEL WL +VE EL + Q GE+ Q Q R KELKKE +
Sbjct: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3726
Query: 4160 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
+ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ
Sbjct: 3727 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3786
Query: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK F+++I+RHKD +D+L
Sbjct: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
+I C EE+K +++K + +++ Y+ I +NSERY +LERAQ LVNQFWETYEEL PW
Sbjct: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 4399
+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKPHIDK+ K GPQL EL+P EG
Sbjct: 3907 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3966
Query: 4400 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLR 4459
++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ FHDKI+ +LE+LE + RLR
Sbjct: 3967 FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ---FHDKIDQILESLERIVERLR 4023
Query: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4519
PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RGEE+I RS G DKD++AK +Q
Sbjct: 4024 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
Query: 4520 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI 4579
DKLDQMVF WE+I EERE K LDV+ELAEKFW D +L+ TIKDTQD + DLE PGI
Sbjct: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
Query: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639
DPS++KQQ EAAETI+EE DGL EEL+ + LG++LI ACGE +KP V+KSIDE+N+AW+
Sbjct: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
Query: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699
+LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D KL +M P+GTDL TVK Q+ E
Sbjct: 4204 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4263
Query: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++PL ELK +W++L E+I +RQ
Sbjct: 4264 LKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQ 4323
Query: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
HKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GDPK IE+ELAKHHVL+NDVLA
Sbjct: 4324 HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLA 4383
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
HQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++VL+KTE+R+QQL L+QA+
Sbjct: 4384 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4443
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
GFH EIED LT E L ASKP GGLPETA+EQL+ HME+ + +AKEETY L+ K
Sbjct: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4503
Query: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFI 4999
G+ M L+R + + +Q + L++KW V +K+ ERK+KLEEALNLA EF NSLQ+FI
Sbjct: 4504 GQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
Query: 5000 NWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQK 5059
NWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+HR+QIIELD+TG LK+ SQK
Sbjct: 4563 NWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQK 4622
Query: 5060 QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD 5119
QDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQFHEAW KL++WLE++E LD
Sbjct: 4623 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4682
Query: 5120 SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179
SELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTGR+LKEKT L +D+ KLD+ L
Sbjct: 4683 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDML 4742
Query: 5180 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 5239
E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+DWLY+VEPQLAEDQPVHGD+D
Sbjct: 4743 SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID 4802
Query: 5240 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 5299
LVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD++WVK Q+QELSTRW+TVC
Sbjct: 4803 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4862
Query: 5300 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 5359
LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF G LPDD +AL++LID HKEF
Sbjct: 4863 LSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF 4922
Query: 5360 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
MKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITIIRARFEEVL WAKQHQQRL +
Sbjct: 4923 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4982
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+ VKALIAEHQTFMEEMTRKQP
Sbjct: 4983 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5042
Query: 5480 DVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQ 5535
DVD+VTKTYKR+ +P +H P ++K R+ GRK + P +Q E KNPR+N
Sbjct: 5043 DVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPASSLYPSGSQTQIETKNPRVNL 5101
Query: 5536 LSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFR 5595
L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+WRKKYMRWMNHKKSRVMDFFR
Sbjct: 5102 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5161
Query: 5596 RIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD 5655
RIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 5162 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5221
Query: 5656 AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRS 5715
AY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 5222 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5281
Query: 5716 TVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPS 5775
TVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL +GASQGM FR RGRRS+PS
Sbjct: 5282 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5341
Query: 5776 SRAASPTRSSSSASQSNHSCTSMPSSPAT------------------------------- 5804
SR ASP RS+S +SQ+ + + P PAT
Sbjct: 5342 SRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAE 5399
Query: 5805 ----PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSAS 5860
P + P GSKL+ P + S + +G+ S + A+ +T AD KK+ S
Sbjct: 5400 CSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPS 5457
Query: 5861 RPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS---ESSAAGGQGNSRRGLNKPS 5917
RPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD ++ + SR KPS
Sbjct: 5458 RPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPS 5517
Query: 5918 KIPTMSKKT 5926
KIPT +K+
Sbjct: 5518 KIPTPQRKS 5526
Score = 716 bits (1847), Expect = 0.0
Identities = 792/3865 (20%), Positives = 1615/3865 (41%), Gaps = 324/3865 (8%)
Query: 1812 SYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIIS 1871
+Y+ L+ + + K Q E + + LC+ + + + ++ L+S + +++
Sbjct: 1206 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV--- 1262
Query: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV---LNQHTQLE 1928
+ Q+ ALE + + + + T+ R L F E V N H Q++
Sbjct: 1263 ---DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1319
Query: 1929 GRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQ 1988
RL+DL + + L+ Y D P+ + Q++ IQ
Sbjct: 1320 NRLRDL----------------------EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1357
Query: 1989 FFISEHAQDLSPQQNRQ-MLRLLNELQRSFQDILEQTAAQVDAL--QGHLQQMEQEALV- 2044
E+++ L+ Q N+Q ML E+++S D ++ A Q A LQ M A+V
Sbjct: 1358 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1417
Query: 2045 ---------KTLQKQQNTCHQQLEDLCSWVGQAERAL------AGHQGRTTQQDLSALQK 2089
+ +Q + Q+ DL + + AG + +++ +L++
Sbjct: 1418 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1477
Query: 2090 NQSDLKDLQDDIQNRATSFATVVKDIE--GFMEENQTKLSPRELTALREKLHQA------ 2141
+ + + ++Q ++ + +KD E G ++ K+S E++ +E+L +A
Sbjct: 1478 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1537
Query: 2142 -----------------KEQYEALQEETRV----AQKELEEAVTSALQQETEKSKAAKEL 2180
++Q + LQE + + K+L+E+ TS + E+ A+
Sbjct: 1538 FLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKIVAERQ 1596
Query: 2181 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 2240
E K+K+ + D +T Q L G ++ A DG + + + K
Sbjct: 1597 QEYKEKLQGICDLLT-------QTENRLIGHQE---------AFMIGDGTVELKKYQSKQ 1640
Query: 2241 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK---EQ 2297
++ + M+ Q L +N + FL ++G L+ E++ +++QKL E K EQ
Sbjct: 1641 EELQKDMQGSAQALAEVVKN-------TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQ 1693
Query: 2298 YSTSLAQSEAELKQVQT--LQDELQKF-----LQDHK----EFESWLERSEKELE---NM 2343
+ QS+ EL +V T +++E +K L++ K WL +K+ E
Sbjct: 1694 LNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTK 1753
Query: 2344 HKG-------------------------------------GSSPETLPSLLKRQGSFSED 2366
HK G++ E L ++ + E
Sbjct: 1754 HKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEK 1813
Query: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
+IS + T S Q +L+ + + +E ++ +K+ LK E A K +L
Sbjct: 1814 IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE-LKVHYETALAESEKKMKL- 1871
Query: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
+ L + +F + W+Q E +E L + A D L +L K E++
Sbjct: 1872 --THSLQEELEKFDADYTEFEHWLQQSEQELENL--EAGADDINGLMTKLKRQKSFSEDV 1927
Query: 2487 AEHQ-------VPVEKLQKVARDIMEIEG---EPAPDHRHVQETTDSILSHFQSLSYSLA 2536
H+ + ++ + A+ + +G + + HR VQ D F+SL
Sbjct: 1928 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1987
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS---SLSSGVIQEALATNMKL 2593
+ L+ + + Q +++ LL + E K +S ++ +Q L L
Sbjct: 1988 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT-ASKHLSEPIAVDPKNLQRQLEETKAL 2046
Query: 2594 KQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSL 2651
+ I+ Q+ ++E ++ ++ S A +Q L ++ R+E L E+ L
Sbjct: 2047 QGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 2106
Query: 2652 KKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED----QQ 2707
+ L ++ + ++ +M N L Q + T Q I N+ +E +Q
Sbjct: 2107 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNST-ALQDIISKNIMLEQDIAGRQ 2165
Query: 2708 ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEF 2767
+++ + V + Q ++++L F+E KE + +++ F
Sbjct: 2166 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2225
Query: 2768 RKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS 2827
L Q +L+ ++ TE + K++ + ++++ ++ +E
Sbjct: 2226 ENLSEKLQTFLETKTQAL--TEVDVPGKDVTELSQYMQESTSEFLEHKKHLE-------V 2276
Query: 2828 LENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGV 2887
L +L+ EI+ S G LPS D + ++++ K++++
Sbjct: 2277 LHSLLKEIS---SHG-----LPS---------------DKALVLEKTNNLSKKFKEMEDT 2313
Query: 2888 LHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKA 2947
+ E++E++ + +++ S+ W+ +E K + + E + E K
Sbjct: 2314 IKEKKEAVTSCQEQLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKK 2370
Query: 2948 FLAELEQNSPKIQKVKE---ALAGLL--VTYPNSQEA-------------------ENW- 2982
+ +P+IQKV +L L+ VT P A E W
Sbjct: 2371 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2430
Query: 2983 -------KKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL--MEKEL 3033
KK +++ +E + + +L S L Q S + WL M K
Sbjct: 2431 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2490
Query: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQV 3093
P D + Q +Q K FEA +Q+ + + LT + + T +
Sbjct: 2491 TKWQQTPAPTDTEAVKTQVEQ----NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2546
Query: 3094 ---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 3150
++ L I+ KW EL R +++++ TQ+Q + L + + +SV
Sbjct: 2547 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2606
Query: 3151 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQ-YLKDELKKRLET 3209
+S P + Q ++ + + + ++ + GE L+ +K++L
Sbjct: 2607 PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2666
Query: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
V L +DR + + A+ + Q+Q + L L D ++ + + +S + +
Sbjct: 2667 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2726
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
QL+ ++ ++ + Q +V A E L V K L QL + ++++ +
Sbjct: 2727 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2786
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAML 3389
K + L+ + ++Q D W++ K + ++ + + SL++
Sbjct: 2787 KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDF 2846
Query: 3390 NEVEKRRSLL--EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEE 3447
++ +S + + + ++L+ + +++ ++ + I N D ++++ + L+E
Sbjct: 2847 SKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2906
Query: 3448 MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVD 3507
++ +++E + + ++ ++ LE A ++ KL++ Q+ + V+
Sbjct: 2907 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 2966
Query: 3508 YLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR 3567
L N L+ D + + + Q+ V ++++S +EN + +F
Sbjct: 2967 LLNNTANSLLSVCE--IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEV 3024
Query: 3568 VREMFSQLADLDDELDGMGAIGRDTDS------LQSQIEDVRLFLNKIHVLK-----LDI 3616
+E QL ++LD ++G S LQ+Q + ++ +++ + K L +
Sbjct: 3025 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVV 3084
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK 3676
EAS++ +GT D+L ++E + ++ L+++ + LE L + F
Sbjct: 3085 EASDS--------KGTSDVL---LQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNT 3133
Query: 3677 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
++ + ++ VG + E + +Q K F K +++ L N + +
Sbjct: 3134 IREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK-KLEALMASNDNANKTCKMM 3192
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796
+ + D+ G++ D+E ++ + N L + R Q++ + +F L+ L
Sbjct: 3193 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQ 3252
Query: 3797 DTEELIANQKPPSAEYKVVKAQIQEQKLLQR----LLDDRKATVDMLQAEGGRIAQSAEL 3852
EE +Q P E + + Q+ K+ Q+ L ++ V+ L G I +A+
Sbjct: 3253 KAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ--GLIQSAAKS 3310
Query: 3853 ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLA 3912
+ + L+ + +RW L K A R QL++ L+ +F + E + ++ TE+ +A
Sbjct: 3311 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3370
Query: 3913 NSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID 3972
N +P + ++ QI K L+ +++ + V + G+ +++ PA++ + +++
Sbjct: 3371 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3430
Query: 3973 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV 4032
L +R+ + ++ + L+ A+ F E + WL +E +L + +
Sbjct: 3431 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3490
Query: 4033 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 4092
L Q A H AL ++I+N K++ QA+ GQ+L ++ E+ ++Q KLD + Y +I
Sbjct: 3491 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550
Query: 4093 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKEL 4152
S L+QA A F EL WL EV ++L+ Q + E + + Q + L
Sbjct: 3551 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3610
Query: 4153 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGL----DKLVSDANEQYKLVSDTIGQRVD 4208
+++++ L V++ LEL+ + + DKL + +YK ++
Sbjct: 3611 QEDIL---LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA-IKARYKDITKLSTDVAK 3666
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
++ A+Q +++ + W+ + + +L++ L+ ++ + K + +
Sbjct: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3726
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
K +D L S + + L++ ++Y +S +++ ++ A + Q
Sbjct: 3727 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3786
Query: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 4388
F + + WI ET + L ++ +Q Q + + I HK ID L+K G
Sbjct: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
Query: 4389 PQ-LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ + + EE + +++K K Y I + +R L L+ A S Q E ++++ P
Sbjct: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
L +++ S+L P L E + +R+ +++ + + +P + + + G +L+ S
Sbjct: 3907 LTETQSIISQLPAPAL---EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP 3963
Query: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567
G IQ+K + IK ++R + + + + +F + +L +++
Sbjct: 3964 G-----EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018
Query: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK--- 4624
+ + S + IK+Q+ + + + + L E ++ G ++I G T+K
Sbjct: 4019 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4078
Query: 4625 -PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683
V+ +D+M WEN++ +ER KL D M+ A ++ ++ + +T + +
Sbjct: 4079 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4138
Query: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
G D + VK Q + + E+ Q E++ + + G ++ A E D+ I+++ + E
Sbjct: 4139 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI-AACGEPDKPIVKKSIDE 4197
Query: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
L W++L + R KLE A+ A Q+Q L+ + W+ L + PI D + +
Sbjct: 4198 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4257
Query: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLES-SAGDDASSLRSRLEAMNQCWESVLQ 4862
+ ++ + K++ Q +E +N LL+ + D +++ L + W+S+ +
Sbjct: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4317
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4922
+ R+ +L+ L F +++ L LT E LS KP GG P+ +L H L
Sbjct: 4318 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4377
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
+ + A + T + ++K L+ S + + +L Q+W V K E+RK +L+
Sbjct: 4378 QNDVLAHQSTV-EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4436
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
AL A F +++ WLT E+ L + P + T Q+ H A +
Sbjct: 4437 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4496
Query: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
L Q G Q+ K I + +++ +WE V + ER L++A A +FH
Sbjct: 4497 YKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4556
Query: 5103 AWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL 5162
+ + I+WL AE L+ S D + Q+ +HK F + + +TG L
Sbjct: 4557 SLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL 4616
Query: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
K + +D + N L V+ +W+ V + VER L++A + QF +A L++WL
Sbjct: 4617 KYFS-QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS--RDDT 5280
+ E L + + D D + + HK FQK LG + R+GR L E + DD
Sbjct: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4735
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
+ L EL +WDT+C SV +Q++LE+AL + F D + L++WL E L
Sbjct: 4736 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4795
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
+ D + + +LID HK F K++ ++ V + ++ D + +K + +
Sbjct: 4796 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKVQMQELS 4854
Query: 5401 ARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRV 5460
R+E V + Q RLE AL + ++ LL W+ AE TL R +P + D +
Sbjct: 4855 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTL--RFHGVLPDDEDAL 4912
Query: 5461 KALIAEHQTFMEEMTRKQPDVDRVT 5485
+ LI +H+ FM+++ K+ ++++ T
Sbjct: 4913 RTLIDQHKEFMKKLEEKRAELNKAT 4937
Score = 442 bits (1137), Expect = e-123
Identities = 584/3078 (18%), Positives = 1246/3078 (40%), Gaps = 292/3078 (9%)
Query: 1795 QNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDL 1854
Q TR L ++ + L L + N+E K+ + LN LQD++ + +LE+++
Sbjct: 2107 QITLTRSLSVQ--DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2164
Query: 1855 TTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914
+ ++ E V + + + +L+ K+L S S L +
Sbjct: 2165 QSSINAMNEKVKKFM----ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL-- 2218
Query: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC-LQQY-EDLKQP 1972
KTKV E + L+ ++ K L +E+DV ++ L QY ++
Sbjct: 2219 --KTKV----ELFENLSEKLQTFLETKTQAL------TEVDVPGKDVTELSQYMQESTSE 2266
Query: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032
E K L+ L + E + P +L N L + F++ +E T
Sbjct: 2267 FLEHKKHLEVL----HSLLKEISSHGLPSDKALVLEKTNNLSKKFKE-MEDTI------- 2314
Query: 2033 GHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQS 2092
E++ V + Q+Q + ++ L SW+ + + + Q +DL K+
Sbjct: 2315 -----KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLE 2366
Query: 2093 DLKDLQD----------DIQNRATSFATVVKDI-------------------EGFMEENQ 2123
D K LQ+ + N S ++ + EG +
Sbjct: 2367 DTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2426
Query: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183
+ + LT++++ + YE L + EL + S LQ+ E+S
Sbjct: 2427 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL-SKLQKAQEES--------- 2476
Query: 2184 KKKIDALLDWVTSVGSSGGQ-LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 2242
A++ W+ + + + T P + +E+ + VN+ E DK
Sbjct: 2477 ----SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532
Query: 2243 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ------QKLGELKE 2296
E+++ T A P +QML Q+L +L
Sbjct: 2533 LTELLEENPD------------TPEA------------PRWKQMLTEIDSKWQELNQLTI 2568
Query: 2297 QYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSL 2356
L +S L Q QT++ +L++ WL E + + P L +
Sbjct: 2569 DRQQKLEESSNNLTQFQTVEAQLKQ----------WLVEKELMVSVLGPLSIDPNMLNTQ 2618
Query: 2357 LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYT 2416
++ ++ + K +T +GQ +L + G++PS + +VK++L T+++
Sbjct: 2619 RQQVQILLQEFATRKPQYEQLTAAGQGILS-----RPGEDPS-LRGIVKEQLAAVTQKWD 2672
Query: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
+L + + ++ + + Q+Q+ SL + + + L+ V++ P + +QL
Sbjct: 2673 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA--VSTHPDAMNQQL 2730
Query: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
T +++++E+ + + ++ Q + D+ + E + + IL F+ +
Sbjct: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYL-KAELSRQLEGILKSFKDVEQKAE 2789
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
LQ A A S Q+ + ++ S V++ + + +
Sbjct: 2790 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2849
Query: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
+ Q E T + + A LQ +L + ++ Q +E+E+ LK+ L
Sbjct: 2850 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2909
Query: 2657 QA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2712
+A E E L + + N + + + + + +++ L EM+ ++
Sbjct: 2910 KALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE--NSIAKLKSLQKEMDQHFGMVEL 2967
Query: 2713 LEHLVTE-LSSCGFALDLCQHQDR-------------------VQNLRKDFTELQKTVKE 2752
L + LS C ++ +++ ++N+ + F E Q+ KE
Sbjct: 2968 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3027
Query: 2753 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812
++ +EQLD L Q + + + + S+ A L+ Q++ K L D
Sbjct: 3028 SKRQLQCAKEQLDIHDSL--GSQAYSNKYLTMLQTQQKSLQA--LKHQVDLAKRLAQDLV 3083
Query: 2813 -----SKG----------------TLVEEINCKGTSLE----------NLIMEITAP--- 2838
SKG TL ++++ K + LE N I E+ +
Sbjct: 3084 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 3143
Query: 2839 -----DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2893
DS G ++ ++ + K L + + N K K+ E
Sbjct: 3144 FDDELDSMAPVGRDAETLQKQKETIKAF--LKKLEALMASNDNAN-KTCKMMLATEETSP 3200
Query: 2894 SLQAILNRMEEVHKEANSVLQWLESKEE----VLKSMDAMSSPTK--------------- 2934
L I +E + K+ N +L +++EE +K ++ S K
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3260
Query: 2935 -------TETVKAQAESNKAF-LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ 2986
TET+ Q K F E+E K Q V GL+ + S + +
Sbjct: 3261 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 3320
Query: 2987 EELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPN 3046
+++N+RW+ + R QL+E+ H FQ A L W+++ E ++ P S +
Sbjct: 3321 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3380
Query: 3047 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT--GPGDVSLSTSQVQKELQSINQKW 3104
++ AQ Q+ + + + + R+ E + + I T P D ++ K+L ++ +W
Sbjct: 3381 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD----KVKILKQLSLLDSRW 3436
Query: 3105 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 3164
L +K +R+ Q++ V + Q+ E L+ L+E + + +RL I TQ +++Q+
Sbjct: 3437 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3496
Query: 3165 ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADR 3224
+ + D+ + + +A ++ L VL + KD ++ +L+ + +++ + R
Sbjct: 3497 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED-KDMVQSKLDFSQVWYIEIQEKSHSR 3555
Query: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 3284
LQ AL + + F + EL WL++ + +K E L Q E Q+ +
Sbjct: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3615
Query: 3285 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 3344
+ + + G LL G+E +Q++L +K +++++K + D L+ +Q
Sbjct: 3616 LRKQNVDQALLNGLELLKQT-TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3674
Query: 3345 AQKYQWHVEDLVPWIEDCKAKMSELRV-TLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 3403
A++ E+L W++ + ++ L + + +R K + E + ++LL+ LN
Sbjct: 3675 ARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3734
Query: 3404 SAADILINSSE-ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREF-QESFKN 3461
+ L+ +G+ A N+ V++ + K ++ R ++F Q +
Sbjct: 3735 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3794
Query: 3462 IEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA-QQEVLQALEPQVDYLRNFTQGLVEDA 3520
+ E K + + D Q ++ L+ + E+L+ + D +++ + + A
Sbjct: 3795 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK--IMTA 3852
Query: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
+ + + + + + + Q + + +E + QF E++ L +
Sbjct: 3853 CSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQS 3912
Query: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE---EEGTLDLLG 3637
+ + A + ++L+ Q E+ R I K I+ +LE EG
Sbjct: 3913 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG----FS 3968
Query: 3638 LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV 3697
++ + A + ++ E K R L+ + + F+ K+ + ++ E +
Sbjct: 3969 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 4028
Query: 3698 GTEVEIINQQLADFK--MFQKEQVDPLQMKLQQVNGLGQGLIQSAG---KDCDVQGLEHD 3752
EVE I +Q+++ K E++ PL L+Q G+ +I +G KD + ++
Sbjct: 4029 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQDK 4085
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812
++++ W ++ V +R A+L + + KF L+ + DT++ I + + P +
Sbjct: 4086 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4145
Query: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872
VVK Q + + ++ +D + +D++ G + + D+ + ++ L S W L
Sbjct: 4146 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4205
Query: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI---- 3928
R +LE+ + A Q+ + + + D++ + KLA+ P+GT ++QQI
Sbjct: 4206 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4265
Query: 3929 -IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+ +A ++ IE + HQA + L +T +++ + + + L+ + +++R
Sbjct: 4266 QFKSEAYQQQIEMERLN-HQAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
+ L+ AL F E+L WL E LS + + A H L ++
Sbjct: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107
+ + V+ K G L++ + GEE +Q KL+ + R+ ++ + + + L+ A +
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4441
Query: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM----EHRLVL 4163
A F E+L WL + E L S P G +P+ + Q + EV
Sbjct: 4442 AKGFHGEIEDLQQWLTDTERHLLAS---KPLG-GLPETAKEQLNVHMEVCAAFEAKEETY 4497
Query: 4164 DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 4223
++ + + +L P A +D+ +++ E+++ V + +R +++ A+ + ++ +
Sbjct: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
Query: 4224 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF 4283
+ W+ + ++ L L D Q+ K F+ ++ H++ + EL + +
Sbjct: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Query: 4284 GTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEET 4343
++ +++ S+ ++E + ER L+ A+ QF E + +L W+EE+
Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
Query: 4344 RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN--PEEGEM 4401
+ A D ++++ Q + ++ ++S+ D + G LKE ++
Sbjct: 4678 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737
Query: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
+++ + + + I + +R L+EA+ S Q T D ++ +++ L + +L
Sbjct: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT---DALQALIDWLYRVEPQLAED 4794
Query: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521
+ ++D + I ++K+ EL K S +ALKR ELI +G+ D + ++Q
Sbjct: 4795 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQ-- 4849
Query: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4581
+ ++ WE + A + ++ + L AE+F + ALL + + + + D
Sbjct: 4850 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 4909
Query: 4582 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4641
++ ++ + ++ + EL +G ++ C ++ I + +E +
Sbjct: 4910 DALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4969
Query: 4642 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD--NTVIKLCTMPPVGTDLNTVKDQLNE 4699
K+ ++L A+ + Q+ L+A+ WL T + + ++ VK + E
Sbjct: 4970 LAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5029
Query: 4700 MKEFKVEVYQQQIEMEKL 4717
+ F E+ ++Q +++K+
Sbjct: 5030 HQTFMEEMTRKQPDVDKV 5047
Score = 404 bits (1039), Expect = e-111
Identities = 676/3612 (18%), Positives = 1415/3612 (39%), Gaps = 437/3612 (12%)
Query: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
++ L+K+ QN +++ +DL +WV + + L RT SDL
Sbjct: 625 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 671
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149
++ ++N + +++ E ++E K+S ++TA EKLH+ + QY L
Sbjct: 672 PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 728
Query: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201
+R ++ L+ V+ A + E E+ + A + +E I D+ +
Sbjct: 729 NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 788
Query: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258
Q N+ +++++ L + A T + Y Q Q C+ ++ +E +
Sbjct: 789 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 848
Query: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317
+ F N E L+ ++ +YS + S +L+ VQ +
Sbjct: 849 EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 892
Query: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368
E ++ LQ + + +++ ++ + P +K + + I
Sbjct: 893 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 952
Query: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421
SH+ + ++ +G + + F KE ++ N ++ + ++ T H
Sbjct: 953 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 1008
Query: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480
SH+NM + +H N D ++A + A+++ +L PG Q+ L+ +
Sbjct: 1009 -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 1053
Query: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540
E+ E + DI ++E E ++ QE S AER
Sbjct: 1054 SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 1099
Query: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593
Q +SV S +++I +N E + + + + + ++ L ++ KL
Sbjct: 1100 -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1152
Query: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649
K+++ R K L T + F + A S++ L+ +L V Q Q+ +K
Sbjct: 1153 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 1212
Query: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709
++ +L + E L + + + ++A N +I + +++ E++++++
Sbjct: 1213 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 1268
Query: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
LE + + + LD H+++ L + + + + R +D
Sbjct: 1269 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1328
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
+ L +R W+++ E + K E Q E+ K+L + LV E
Sbjct: 1329 GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1380
Query: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874
I K + ++ T D + +T + V S S V I +
Sbjct: 1381 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440
Query: 2875 SDVNLKYEKL-----------GGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2923
D+ +Y L G L +E +++ +E ++A + +W+ + + L
Sbjct: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1500
Query: 2924 KSMDAMSSP-------------TKTETVKAQAESNKAFLAEL--EQNSPKIQKVKEALAG 2968
K + P TK E + ++ + FLA+ + + ++++ +
Sbjct: 1501 KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1560
Query: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ------------LEESASHLAC 3016
L +Y N +E+ K++QE S + E VA ++Q L ++ + L
Sbjct: 1561 LQESY-NLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIG 1619
Query: 3017 FQAA-----------ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEAR 3065
Q A + Q + ++K++ + N N K+ + + +E +A
Sbjct: 1620 HQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1679
Query: 3066 RQQH--------EQLNEAAQ-------GILTGPGDVSLSTSQVQKELQSINQK------W 3104
+Q EQLN A+ ++T K+L+ K W
Sbjct: 1680 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739
Query: 3105 VELTDKLNSRSSQIDQAIVK--STQYQE--LLQDLSEKVRAVGQRL--SVQSAISTQPEA 3158
+ DK + R+ + +++ T +QE + E+ G L V + T E
Sbjct: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799
Query: 3159 VKQQLEET----SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 3214
+ QQ ++ +I S + + + AQ L ++ QYL E K++L+ L
Sbjct: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQG-----QYLSPEEKEKLQKNMKEL 1854
Query: 3215 QGLEDLAADRINRLQAALASTQQFQQMFD----ELRTWLDDKQSQQAKNCPISA-KLERL 3269
+ + A + S Q+ + FD E WL + Q+ +N A + L
Sbjct: 1855 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE-QELENLEAGADDINGL 1913
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS-----------VPPGEEKRTLQNQLV 3318
++L+ + F + + H G I G +L + V R +Q +L
Sbjct: 1914 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1973
Query: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE---LRVTLDP 3375
+ + L K + LKD + K Q Y+ L+ ++ C+A S+ + +DP
Sbjct: 1974 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2033
Query: 3376 VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI----------NSSEADEDGIRDEKA 3425
L+ L +KA+ ++ ++ +E L A++L+ N + D I
Sbjct: 2034 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 2093
Query: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALGSQAC 3484
++++++ E+LQ + L E + N+E + K Q ++ ++ Q
Sbjct: 2094 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL---KEQGQVPLNSTALQDI 2150
Query: 3485 SNKNL---EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL 3541
+KN+ + + +Q + A+ +V T D S AS L + + F
Sbjct: 2151 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETT--------DPSTASSLQAKMKDLSARFS 2202
Query: 3542 EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIED 3601
E + ME + E+F L ++ LQ+ +E
Sbjct: 2203 EASHKHKETLAKMEELKTKV--------ELFENL----------------SEKLQTFLET 2238
Query: 3602 VRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQE 3661
L ++ D+ + +E T + L K+ LE L+ +++ G +
Sbjct: 2239 KTQALTEV-----DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 2293
Query: 3662 QLELTLGRVEDFYRKLKGLND--------ATTAAEEAEALQ--------WVVGTE----- 3700
L L + + +K K + D T+ E+ +A Q W+ T
Sbjct: 2294 --ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI 2351
Query: 3701 ------VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL----------------IQ 3738
E + + L D K Q E+ ++Q+VN G L ++
Sbjct: 2352 VQPSFGAEDLGKSLEDTKKLQ-EKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVK 2410
Query: 3739 SAGKDCDVQG----------------LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
S G + +G ++ DM +I+ + L + +IA+L L
Sbjct: 2411 SGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQ 2470
Query: 3783 KFQDALEPLLSWLADTEELIA--NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
K Q+ ++ WL + Q P + + VK Q+++ K + L V L+
Sbjct: 2471 KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2530
Query: 3841 AE-GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3899
+ + ++ + + + L ++S+W EL RQ++LE+ QF
Sbjct: 2531 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2590
Query: 3900 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL- 3958
+ +L E ++ P+ + Q + + L ++ Q GQ + S
Sbjct: 2591 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRP 2650
Query: 3959 -TSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
P+ +G++ E++ ++ ++ + + + +DQA+ + + + + L++++
Sbjct: 2651 GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLD 2710
Query: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTTGEEVL 4074
+KLSS D +++Q + +EI KK IK QAL L EE L
Sbjct: 2711 NKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQ----IKVAQALCEDLSALVKEEYL 2766
Query: 4075 L--IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+ +L+GI + D+ + ++ L+ A + +FQ + WL +EE S
Sbjct: 2767 KAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKS 2826
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA 4192
S + + + K+ K + + + LL + L ++
Sbjct: 2827 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTI 2886
Query: 4193 NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL----MALGPIRLEQ 4248
+ + + +R +++ +++++ +Y++ + W+ + + L L P E
Sbjct: 2887 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP--AEG 2944
Query: 4249 DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 4308
+ + A+L K+ ++ +H ++ L + + + C E K V+ ++ +SLIQ+ + +
Sbjct: 2945 ENSIAKL---KSLQKEMDQHFGMVELLNNTANSLLSVC-EIDKEVVTDENKSLIQKVDMV 3000
Query: 4309 S-LLNSERYARLERAQVLVNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQ 4364
+ L+S+++ LE +F E +E ++ E + L S A ++ L Q
Sbjct: 3001 TEQLHSKKFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3059
Query: 4365 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
+ + L+ +H+ + K L ++ + + V + + ++ + ++V ++
Sbjct: 3060 TQQKSLQ--ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3117
Query: 4425 LALDEAVS-----QST------QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 4473
L+ + Q+T Q EF D+++ M + + + I A + K+
Sbjct: 3118 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3177
Query: 4474 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4533
++ N +A K A + +L+G + D + +K+ LD
Sbjct: 3178 LMASNDNA----NKTCKMMLATEETSPDLVGIKR--DLEALSKQCNKLLD---------- 3221
Query: 4534 ARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET 4593
RA+ RE + ++ E+F+ + ++ ++ G++ I QQ+ +
Sbjct: 3222 -RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 3280
Query: 4594 I-KEETDGLHEELEFIRILGADLI-FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4651
KEE + L + + + LG LI A T + +D++N W+ LNK +R +
Sbjct: 3281 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 3340
Query: 4652 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4711
L++A+ ++QD L+++ W+ +T + P + VK Q+ E K + + ++
Sbjct: 3341 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRK 3400
Query: 4712 IEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771
+E + +GE + A + D+ I + L+ L WE L K R +LEG + Q
Sbjct: 3401 STVEVIKREGEKIATTA-EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3459
Query: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
F LE L WLT E+ L PI +E ++A+H L++D++ H + G
Sbjct: 3460 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3519
Query: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L S+ +D ++S+L+ + + +K+ R + LQ L A+ F + + +
Sbjct: 3520 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 3579
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + +LS E +Q L + +++ +Q L G L LL +
Sbjct: 3580 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNG-LELLKQTTGD 3638
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
+ + ++ ++ ++ + LE+AL LA ++ +E WL E L +
Sbjct: 3639 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL-L 3697
Query: 5012 ASPPSLILNTVLSQIE-EHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLV 5070
+ ++ SQ + K E ++ + L++ + L L + ++ ++
Sbjct: 3698 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVA 3757
Query: 5071 SVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
R+ V ++ +D A R++QF +A + W+ + E L S +I + D+
Sbjct: 3758 EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3817
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
QL K F + + + D +++G + E+ Q + L +V +DT+C
Sbjct: 3818 TSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM-TACSEEEKQSMKKKLDKVLKNYDTIC 3876
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
+ ER +LE A QF + + L WL + + +++ + + + + H+
Sbjct: 3877 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQ 3936
Query: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
++ + + + + ++G +L+E S + ++ + T + + + + L++
Sbjct: 3937 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 3996
Query: 5311 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
A+ Q+ F D + +LE L + LR ++ + E ++ I +K +E+ +
Sbjct: 3997 AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLY 4056
Query: 5371 NSAVAMGEVILA 5382
+ GE ++A
Sbjct: 4057 ETLKQRGEEMIA 4068
Score = 381 bits (978), Expect = e-104
Identities = 610/3185 (19%), Positives = 1269/3185 (39%), Gaps = 392/3185 (12%)
Query: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
+SSLL + + + + + ++ LL + E++ L+ + S D+
Sbjct: 630 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 671
Query: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2653
+S LE + V R +E +S+ + + K++E+ Q L L EK ES K
Sbjct: 672 PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 726
Query: 2654 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2701
LL + E L F+ + L N+ +++ + + N+
Sbjct: 727 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 786
Query: 2702 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2735
E++ ++EN+ +++ + +L + + L LCQ ++
Sbjct: 787 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 846
Query: 2736 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792
N K+ T+ + +K+ + SC ++ KL Q+ ++E E + T
Sbjct: 847 YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 905
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2848
+ K I LK D K ++ + C +E I + + A +S ++
Sbjct: 906 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 965
Query: 2849 PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2908
G+ + T + D+++ ++ Q +L E H
Sbjct: 966 SPTGNEAMVPSVCFTVPPPNKEAVDLAN-------------RIEQQYQNVLTLWHESHIN 1012
Query: 2909 ANSVLQW--LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL 2966
SV+ W L ++ + +++ + S T Q SN L ++ + + +
Sbjct: 1013 MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN---LQSRFEDFLEDSQESQVF 1069
Query: 2967 AGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 3026
+G +T + + QE L S A + + EES +L + +LR
Sbjct: 1070 SGSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRL 1119
Query: 3027 WLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086
E L+ + PL D + F + E E +++ E+L + G +T +
Sbjct: 1120 ENCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEE 1172
Query: 3087 SLSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL----- 3132
S + + ++ + + +N S+ ID+ ++K+TQ E L
Sbjct: 1173 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 1232
Query: 3133 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 3192
L E+ + + ++++ IST +KQ E E R L+ E+++A+ + DE+
Sbjct: 1233 TKLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 1288
Query: 3193 LIGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 3251
E+ L D K++ + + Q + +R+ L+ S + ++ + L W+
Sbjct: 1289 TYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ- 1347
Query: 3252 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 3311
++E Q ++QEN+ E +
Sbjct: 1348 -------------QVETTQRKIQENQP-----------------------------ENSK 1365
Query: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 3371
TL QL + K E+ K QS++ +C + A++Y V+D +A + +
Sbjct: 1366 TLATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1421
Query: 3372 TLDPVQLESSLLRSKAMLNEVEKRRS--------LLEILNSAADILINSSEADEDGIRDE 3423
+ PV+ + ++ E R+ + + + A D L E +E + +E
Sbjct: 1422 S--PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL-KRLEEEEKSLEEE 1478
Query: 3424 K-------AGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF 3476
K + + + +++ L+ + + + + E ++++ A +++F
Sbjct: 1479 KKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLF 1538
Query: 3477 DALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3536
A +++ +L Q + LQ Y F++ L + + + + VA
Sbjct: 1539 LAKHGDKMTDEERNELEKQVKTLQE-----SYNLLFSESLKQLQESQTSGDVKVEEKIVA 1593
Query: 3537 --QQEFLEVKQRVNSGCVMMENKLEG------IGQFHCRVREMFSQLADLDDELDG---- 3584
QQE+ E Q + EN+L G IG +++ S+ +L ++ G
Sbjct: 1594 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1653
Query: 3585 MGAIGRDTDSLQSQ------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
+ + ++T++ + ED L K++ K+ E + +E + +
Sbjct: 1654 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1713
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVE-DFYR---KLKGL----------NDAT 3684
K E E + K E K + E L L V+ D R K K + D
Sbjct: 1714 KEETEKV--AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGK 1771
Query: 3685 TAAEEAEA---------LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3735
+A E + + VGT E +NQQ K Q E++ + Q
Sbjct: 1772 SAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQSAQV 1830
Query: 3736 LIQSAGKDC---DVQGLEHDMEEINARWNTL---NKKVAQRIAQLQEALLHCGKFQDALE 3789
L++ G+ + + L+ +M+E+ + T ++K + LQE L KF
Sbjct: 1831 LLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---EKFDADYT 1887
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
WL +E+ + N + + + + +++ QK + K + + G R+ ++
Sbjct: 1888 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1947
Query: 3850 AE------------LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA 3897
A+ A ++ +L+ R+ L SK L+D++ + + + +
Sbjct: 1948 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 2007
Query: 3898 EPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955
+ L E + SEP+ +Q+Q+ KAL+ I + V + K + L
Sbjct: 2008 CGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 2067
Query: 3956 SSLTS---PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW 4012
PA+ + + +D + RY ++ + L L+ + + E+L+W
Sbjct: 2068 LDARGSLLPAKNDI-QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2126
Query: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
+ VE L L + ++ L ++I R+ +++ + + ++ T
Sbjct: 2127 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPST 2186
Query: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+Q K+ + R+++ + + L +E+ + F++ E+L +L + L
Sbjct: 2187 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE- 2245
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL-VPWRAREGLDKLVSD 4191
G+ + + Q +E E +EH+ L+ ++ + + + +P L+K ++
Sbjct: 2246 --VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNN 2302
Query: 4192 ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-- 4249
++++K + DTI ++ + + + ++ ++ + +W+ ET +K+ + P +D
Sbjct: 2303 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2362
Query: 4250 ---QTTAQLQVQKAFSIDIIRHKD----SMDELFSH------------------RSEIFG 4284
+ T +LQ + + I+ + S+ L S E
Sbjct: 2363 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2422
Query: 4285 TCGEE-----QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
T EE T +++ + YE + LL ++ A L + + E + W
Sbjct: 2423 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2482
Query: 4340 IE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL-- 4394
++ +T Q P+P D E ++ Q E+ + AE K +++K+ ++ +L EL
Sbjct: 2483 LQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFE---AELKQNVNKVQELKDKLTELLE 2538
Query: 4395 -NPEEGEMVEEKYQKAE--NMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
NP+ E K E + + ++ + R L+E+ + TQ +++ L
Sbjct: 2539 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2598
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
E + S L + P ++ R+ + + E +P +E L G+ ++ R G D
Sbjct: 2599 ELMVSVLGPLSIDPNMLNTQRQQV---QILLQEFATRKPQYEQLTAAGQGILSR-PGEDP 2654
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
L ++++L + W+ + + +R + + ++ + +L + D + +
Sbjct: 2655 SLRG-IVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKL 2713
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADL-IFACGETEKPEVRKS 4630
+ P + QQ+E A+ +K+E ++++ + L DL E K E+ +
Sbjct: 2714 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2773
Query: 4631 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL 4690
++ + +++++ + + ++ L+ A ++ Q+Q + WLD + P+ L
Sbjct: 2774 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2833
Query: 4691 NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN 4750
+ ++ + + K+F + Q EK +GE +L K T +++ ++ L +K W+
Sbjct: 2834 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK-TQGSEKAALQLQLNTIKTNWDT 2892
Query: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
+++ R++KL+ +L +++ +E L W+ + L+ + DP E +AK
Sbjct: 2893 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKL 2951
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
L+ ++ H VE +N N LL D E + +S++QK + +Q
Sbjct: 2952 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDK--------EVVTDENKSLIQKVDMVTEQ 3003
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQ----- 4925
L S + + ++F SK + + A+EQLD H L SQ
Sbjct: 3004 LHSKKFCLENMTQKFKEF----------QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 3053
Query: 4926 ----LKAKEETYNQLLDKGRL-------MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKM 4974
L+ ++++ L + L +++ DS S V + Q+ +S ++
Sbjct: 3054 YLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3113
Query: 4975 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
+E+ S LE L FQN+++E + + L+ +P T+ Q E K F
Sbjct: 3114 DEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK 3173
Query: 5035 EVNAHRDQIIELDQTGNQLKFLSQ-KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
++ A ++T + + D+V IK L ++ + K++ R+ R ++
Sbjct: 3174 KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 3233
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK----TLGGKQ 5149
KR ++F+ K+ L+ AE H +S+ + + + I QL+ K FQK L GKQ
Sbjct: 3234 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3293
Query: 5150 PVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
+ G+ L + +Q L++ L +V +W T+ K +R +L+EALL G+
Sbjct: 3294 QDVNW---LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3350
Query: 5210 FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 5269
F DAL++L+ W+ E +A +P + +V + K+ Q+ L R TV+V+KR G
Sbjct: 3351 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3410
Query: 5270 RELIENSRD-DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 5328
++ + D + QL L +RW+ + + ++ +LE A+ F +T+ L EW
Sbjct: 3411 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3470
Query: 5329 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 5388
L+ E+ L + L+ I HK + ++ AV++G+ + + +
Sbjct: 3471 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED 3530
Query: 5389 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI---------- 5438
++ + + + E+ + + L+ AL E EL+ W+
Sbjct: 3531 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKL 3590
Query: 5439 ------------QWAETTLIQRDQEPIPQNIDR--VKALIAEHQTFMEEMTRKQPDVDRV 5484
Q +E ++Q D QN+D+ + L QT +E+ Q ++ +
Sbjct: 3591 SVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 3650
Query: 5485 TKTYK 5489
YK
Sbjct: 3651 KARYK 3655
Score = 60.8 bits (146), Expect = 4e-08
Identities = 181/985 (18%), Positives = 364/985 (36%), Gaps = 178/985 (18%)
Query: 4666 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4723
+Q + +W+D ++L G+DL +V+ L K +E ++ ++ K++
Sbjct: 648 VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
Query: 4724 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4783
K T E H E+ K+ + E L L F + WL
Sbjct: 707 APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 755
Query: 4784 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4839
EE ++ D +A+ H L ++ + +++V + +LL +
Sbjct: 756 NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 810
Query: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4894
++ + AM W +LQ + EQ ++ + F+ E D+L L +
Sbjct: 811 -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 869
Query: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4953
+ S L + +E ++ EL + T L+ K + ++ L +S
Sbjct: 870 RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 925
Query: 4954 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4981
KT + + KW V+S E
Sbjct: 926 LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 985
Query: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041
+EA++LA + Q++ N LTL +S + + + NE++ R
Sbjct: 986 KEAVDLANRIE---QQYQNVLTLWHES-----------HINMKSVVSWHYLINEIDRIRA 1031
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKRA 5097
+ +K + + ++ NL QSR+E ++ S E G + K
Sbjct: 1032 SNVA------SIKTMLPGEHQQVLSNL----QSRFEDFLEDSQESQVFSGSDITQLEKEV 1081
Query: 5098 ---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTLG 5146
KQ+++ K + E ES + L + N D++ Q+ E
Sbjct: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE------ 1135
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ--------- 5197
+ ++++ R + E+ L ++ ++L + LG + +K + ++
Sbjct: 1136 -RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 1190
Query: 5198 ----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVMN 5243
+ + S ++D L+ + + L K+ E +L E++ V D + + N
Sbjct: 1191 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 1250
Query: 5244 LMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELSTR 5293
L+ K ++ E+ ++ L K E+ + ++ D W K + +L R
Sbjct: 1251 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 1310
Query: 5294 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSL 5352
W V ++ LE K + +RDT H L +W+ + E T R + P++++ L +
Sbjct: 1311 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1370
Query: 5353 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQ 5412
++ K + ++E K+ ++ E A + T+ + RA +
Sbjct: 1371 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------- 1418
Query: 5413 HQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 5472
QQ+ + ++A+L+ + ++ T L+ + I D +K L E ++ E
Sbjct: 1419 -QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1477
Query: 5473 EMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5531
E K+ V++ + K NI T ++ + G+ PP SE +
Sbjct: 1478 E---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIST 1523
Query: 5532 RINQLSARWQQVWLLALERQRKLND 5556
+ QLS Q + L + K+ D
Sbjct: 1524 KKEQLSEALQTIQLFLAKHGDKMTD 1548
Score = 51.6 bits (122), Expect = 2e-05
Identities = 138/725 (19%), Positives = 278/725 (38%), Gaps = 93/725 (12%)
Query: 4820 HQATVETVNKAGNELLESS------AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
HQ + + + LE S +G D + L + Q ++ +L+ E RE+Q +S
Sbjct: 1045 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE-REEQEES 1103
Query: 4874 TLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY---SQLKAKE 4930
+ SE+ + L L E +L T E+ D H ++ Q K K+
Sbjct: 1104 VYNL---YISEVRNIRLRLENCEDRLIRQ------IRTPLERDDLHESVFRITEQEKLKK 1154
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE------EA 4984
E +L D + ++ S + SV L + +VV M + S +
Sbjct: 1155 E-LERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT 1213
Query: 4985 LNLATEFQNSLQEFINW--LTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
+NL + + + + L E+ IA N + + I K + +EV+ R
Sbjct: 1214 VNLVLKNTQAAEALVKLYETKLCEEEAVIADK-----NNIENLISTLKQWRSEVDEKRQV 1268
Query: 5043 IIELDQTGNQLKFLSQKQ---------DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
L+ + K +S + D K + RW+ V + R R L+
Sbjct: 1269 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1328
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIK---LQLSKHKEFQKTLGGKQP 5150
K K + + + L DW++ E+ E N P+ K QL++ K + KQ
Sbjct: 1329 GKSLKYYRDTYHPLDDWIQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVSEIEMKQS 1386
Query: 5151 VYDTTIRTGR----ALKEKTL-------LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
D + +K+ L + + QK ++ D + + ++ + +
Sbjct: 1387 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1446
Query: 5200 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 5259
+ Q++ + L + E L E++ H ++ K QK + +
Sbjct: 1447 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH---------VEKAKELQKWVSNIS 1497
Query: 5260 GTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFR 5319
T++ +++G+ + + + + ++LS T+ +L ++K K + R
Sbjct: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI-QLFLAKHGD-----KMTDEER 1551
Query: 5320 DTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEV 5379
+ + ++ L E+ L +E+L+ L ++ KVEEK V E
Sbjct: 1552 NELEKQVKTLQESYNLL--------FSESLKQLQESQTSGDVKVEEKIV-AERQQEYKEK 1602
Query: 5380 ILAVCHPDCITTIKHWITIIRARF--EEVLTWAKQHQQRLETALSELVANAELLEELLA- 5436
+ +C D +T ++ + + F + K++Q + E ++ +A+ L E++
Sbjct: 1603 LQGIC--DLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKN 1660
Query: 5437 ---WIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI 5493
+++ L Q D+ I Q ++ K + E E ++K ++D+V T ++
Sbjct: 1661 TENFLKENGEKLSQEDKALIEQKLNEAK-IKCEQLNLKAEQSKK--ELDKVVTTAIKEET 1717
Query: 5494 EPTHA 5498
E A
Sbjct: 1718 EKVAA 1722
Score = 40.0 bits (92), Expect = 0.069
Identities = 37/141 (26%), Positives = 63/141 (44%), Gaps = 29/141 (20%)
Query: 5430 LLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME-EMTRKQPDVDRVTKTY 5488
++ L+ WI+ TT+ +R P N +KAL ++ F E E+ K+ + ++ + Y
Sbjct: 319 MVNYLIQWIRHHVTTMSERT---FPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLY 375
Query: 5489 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5548
K I +IE GR L Q P N + W ++ + L
Sbjct: 376 KLLEI------WIEF----GRIKLLQGYHP---------------NDIEKEWGKLIIAML 410
Query: 5549 ERQRKLNDALDRLEELKEFAN 5569
ER++ L ++RLE L++ AN
Sbjct: 411 EREKALRPEVERLEMLQQIAN 431
Score = 39.3 bits (90), Expect = 0.12
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363
K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + +
Sbjct: 630 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 688
Query: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423
EE + A + E+ + T + + +++ ++L ++ ++ L+T L
Sbjct: 689 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 743
Query: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483
V+ A L W+ E + D NI R K H M E+ +K+ ++
Sbjct: 744 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 797
Query: 5484 VTKTYKRKNIE 5494
V + ++ +E
Sbjct: 798 VQEIAEQLLLE 808
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 4237 bits (10988), Expect = 0.0
Identities = 2190/4089 (53%), Positives = 2948/4089 (72%), Gaps = 96/4089 (2%)
Query: 1905 RLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQ 1964
RL + ++E EK +H + + ++L+ WV N + L + + +
Sbjct: 1605 RLEEEEKSLEEEK----KEHVE---KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1657
Query: 1965 QYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQT 2024
+ ++ +K QL IQ F+++H ++ ++ ++ + + LQ S+ + ++
Sbjct: 1658 E-------ISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1710
Query: 2025 AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 2084
Q+ Q +E +V Q++ ++L+ +C + Q E L GHQ D
Sbjct: 1711 LKQLQESQTSGDVKVEEKIVAERQQEYK---EKLQGICDLLTQTENRLIGHQEAFMIGDG 1767
Query: 2085 SA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE 2143
+ L+K QS ++LQ D+Q A + A VVK+ E F++EN KLS + + +KL++AK
Sbjct: 1768 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1827
Query: 2144 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 2203
+ E L + ++KEL++ VT+A+++ETEK A K+L E+K KI+ LLDW+++V +
Sbjct: 1828 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1887
Query: 2204 LLTNLPGMEQLSGASLEKG---------------ALDT-TDGYMGVNQAPEKLDKQCEMM 2247
T + + +G ++G L+T DG +G Q E L++Q + +
Sbjct: 1888 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKV 1945
Query: 2248 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 2307
KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ LQ+ + ELK Y T+LA+SE
Sbjct: 1946 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 2005
Query: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV 2367
++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G L + LKRQ SFSEDV
Sbjct: 2006 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 2065
Query: 2368 ISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNLVKDKLKDATERYTALHSKCT 2423
ISHKGDLR++TISG +VL+ S + GK + S V+ KL AT+R+ +L+SKC
Sbjct: 2066 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 2125
Query: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
LG++L L+ +Y +++++ L A +QACEA K LS+ +A DP LQ QL TK LQ
Sbjct: 2126 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2185
Query: 2484 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2543
+++ QV VEKL+K A +++ G P +Q+T D I+ ++ LS S+ ER+ LQ
Sbjct: 2186 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2245
Query: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603
+ +S SVQ+ L+ +L +G VE +L+ + L+S +Q+ ++ N+ L+QDIA ++SS
Sbjct: 2246 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2305
Query: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663
+ A E V +FMET D +TA+ LQ K+ ++S RF + + +E + +++L + E+FE+
Sbjct: 2306 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2365
Query: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC 2723
LS KLQ F+E K++ L + P +D+T Q +QE E + +++L+ L L+ E+SS
Sbjct: 2366 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH 2425
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G D ++ NL K F E++ T+KE+++ +SCQEQLD F+ LV++ + W+KET
Sbjct: 2426 GLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTK 2485
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD---S 2840
+P + S A++L K +E K L + W+ K ++++N G SL NLI +T P +
Sbjct: 2486 KVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA 2545
Query: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900
K+G + + + + + K LT I+ DM+D++ YE LG +L ++ L L+
Sbjct: 2546 AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS 2605
Query: 2901 RMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQ 2960
++++ +E+++++QWL+ + +PT TE VK Q E NK+F AEL+QN K+Q
Sbjct: 2606 KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2665
Query: 2961 KVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020
++K+ L LL P++ EA WK++ E++S+W+ ++T+ RQ++LEES+++L FQ
Sbjct: 2666 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2725
Query: 3021 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080
E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+EF R+ Q+EQL A QGIL
Sbjct: 2726 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2785
Query: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140
+ PG+ V+++L ++ QKW LT +L+ R IDQAIVKSTQYQ LL+ LS+K+
Sbjct: 2786 SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2845
Query: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
+ +LS A+ST P+A+ QQLE +++ +++Q ++K AQ LC++LS L+ E+YLK
Sbjct: 2846 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2905
Query: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
EL ++LE + + +E A + + LQ+A AS+ QFQQM + + WLD K+ +Q K+
Sbjct: 2906 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2965
Query: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
PISAKL+ L+S ++++++F K+L S YE +AEGE+LLL G EK LQ QL +
Sbjct: 2966 PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ-GSEKAALQLQLNTI 3024
Query: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380
K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+ C+ + E++ LDP + E+
Sbjct: 3025 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 3084
Query: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440
S+ + K++ E+++ ++E+LN+ A+ L++ E D++ + DE + Q +D VTE+L +
Sbjct: 3085 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 3144
Query: 3441 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 3500
K LE MTQ+ +EFQE K +++++ AK QL+I D+LGSQA SNK L L+ QQ+ LQ
Sbjct: 3145 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3204
Query: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560
AL+ QVD + Q LV +A D S +L Q E QE + Q+V+ C +E KL+G
Sbjct: 3205 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3264
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
IG F +REMFSQ A+ DDELD M +GRD ++LQ Q E ++ FL K+ L + +
Sbjct: 3265 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN 3324
Query: 3621 AECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679
C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR+EQ+E T+ R+E+FY KLK
Sbjct: 3325 KTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE 3384
Query: 3680 LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3739
+ AEE E Q VG E E INQQL FK+FQKE+++PLQ K Q VN LGQGLIQS
Sbjct: 3385 FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQS 3444
Query: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
A K QGLEHD++++NARW TLNKKVAQR AQLQEALLHCG+FQDALE LLSW+ DTE
Sbjct: 3445 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3504
Query: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
EL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV++++ EG +IA +AE AD+ KI
Sbjct: 3505 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3564
Query: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919
QL L+SRW LL+KA R +QLE I V+A+QFHET EP++++L+ EK+L N EP+GT
Sbjct: 3565 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT 3624
Query: 3920 QTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979
Q +K+++QI +HKALE+DI NH +HQAV IGQSL L+S ++ ++ K+D Q Y
Sbjct: 3625 QASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI 3684
Query: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DKLS + V+D+ + L +Q ++
Sbjct: 3685 EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE 3744
Query: 4040 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR 4099
L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+KL+ IK RY DIT S+ +
Sbjct: 3745 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804
Query: 4100 TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEH 4159
TLEQA QLA + ST+EEL WL +VE EL + Q GE+ Q Q R KELKKE +
Sbjct: 3805 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3864
Query: 4160 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
+ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ
Sbjct: 3865 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3924
Query: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK F+++I+RHKD +D+L
Sbjct: 3925 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3984
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
+I C EE+K +++K + +++ Y+ I +NSERY +LERAQ LVNQFWETYEEL PW
Sbjct: 3985 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 4044
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 4399
+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKPHIDK+ K GPQL EL+P EG
Sbjct: 4045 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 4104
Query: 4400 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLR 4459
++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ FHDKI+ +LE+LE + RLR
Sbjct: 4105 FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ---FHDKIDQILESLERIVERLR 4161
Query: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4519
PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RGEE+I RS G DKD++AK +Q
Sbjct: 4162 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221
Query: 4520 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI 4579
DKLDQMVF WE+I EERE K LDV+ELAEKFW D +L+ TIKDTQD + DLE PGI
Sbjct: 4222 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4281
Query: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639
DPS++KQQ EAAETI+EE DGL EEL+ + LG++LI ACGE +KP V+KSIDE+N+AW+
Sbjct: 4282 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4341
Query: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699
+LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D KL +M P+GTDL TVK Q+ E
Sbjct: 4342 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4401
Query: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++PL ELK +W++L E+I +RQ
Sbjct: 4402 LKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQ 4461
Query: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
HKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GDPK IE+ELAKHHVL+NDVLA
Sbjct: 4462 HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLA 4521
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
HQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++VL+KTE+R+QQL L+QA+
Sbjct: 4522 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4581
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
GFH EIED LT E L ASKP GGLPETA+EQL+ HME+ + +AKEETY L+ K
Sbjct: 4582 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4641
Query: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFI 4999
G+ M L+R + + +Q + L++KW V +K+ ERK+KLEEALNLA EF NSLQ+FI
Sbjct: 4642 GQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4700
Query: 5000 NWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQK 5059
NWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+HR+QIIELD+TG LK+ SQK
Sbjct: 4701 NWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQK 4760
Query: 5060 QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD 5119
QDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQFHEAW KL++WLE++E LD
Sbjct: 4761 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4820
Query: 5120 SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179
SELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTGR+LKEKT L +D+ KLD+ L
Sbjct: 4821 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDML 4880
Query: 5180 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 5239
E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+DWLY+VEPQLAEDQPVHGD+D
Sbjct: 4881 SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID 4940
Query: 5240 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 5299
LVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD++WVK Q+QELSTRW+TVC
Sbjct: 4941 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 5000
Query: 5300 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 5359
LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF G LPDD +AL++LID HKEF
Sbjct: 5001 LSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF 5060
Query: 5360 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
MKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITIIRARFEEVL WAKQHQQRL +
Sbjct: 5061 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 5120
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+ VKALIAEHQTFMEEMTRKQP
Sbjct: 5121 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5180
Query: 5480 DVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQ 5535
DVD+VTKTYKR+ +P +H P ++K R+ GRK + P +Q E KNPR+N
Sbjct: 5181 DVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPASSLYPSGSQTQIETKNPRVNL 5239
Query: 5536 LSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFR 5595
L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+WRKKYMRWMNHKKSRVMDFFR
Sbjct: 5240 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5299
Query: 5596 RIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD 5655
RIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 5300 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5359
Query: 5656 AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRS 5715
AY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 5360 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5419
Query: 5716 TVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPS 5775
TVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL +GASQGM FR RGRRS+PS
Sbjct: 5420 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5479
Query: 5776 SRAASPTRSSSSASQSNHSCTSMPSSPAT------------------------------- 5804
SR ASP RS+S +SQ+ + + P PAT
Sbjct: 5480 SRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAE 5537
Query: 5805 ----PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSAS 5860
P + P GSKL+ P + S + +G+ S + A+ +T AD KK+ S
Sbjct: 5538 CSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPS 5595
Query: 5861 RPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS---ESSAAGGQGNSRRGLNKPS 5917
RPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD ++ + SR KPS
Sbjct: 5596 RPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPS 5655
Query: 5918 KIPTMSKKT 5926
KIPT +K+
Sbjct: 5656 KIPTPQRKS 5664
Score = 716 bits (1847), Expect = 0.0
Identities = 792/3865 (20%), Positives = 1615/3865 (41%), Gaps = 324/3865 (8%)
Query: 1812 SYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIIS 1871
+Y+ L+ + + K Q E + + LC+ + + + ++ L+S + +++
Sbjct: 1344 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV--- 1400
Query: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV---LNQHTQLE 1928
+ Q+ ALE + + + + T+ R L F E V N H Q++
Sbjct: 1401 ---DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1457
Query: 1929 GRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQ 1988
RL+DL + + L+ Y D P+ + Q++ IQ
Sbjct: 1458 NRLRDL----------------------EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1495
Query: 1989 FFISEHAQDLSPQQNRQ-MLRLLNELQRSFQDILEQTAAQVDAL--QGHLQQMEQEALV- 2044
E+++ L+ Q N+Q ML E+++S D ++ A Q A LQ M A+V
Sbjct: 1496 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1555
Query: 2045 ---------KTLQKQQNTCHQQLEDLCSWVGQAERAL------AGHQGRTTQQDLSALQK 2089
+ +Q + Q+ DL + + AG + +++ +L++
Sbjct: 1556 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1615
Query: 2090 NQSDLKDLQDDIQNRATSFATVVKDIE--GFMEENQTKLSPRELTALREKLHQA------ 2141
+ + + ++Q ++ + +KD E G ++ K+S E++ +E+L +A
Sbjct: 1616 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1675
Query: 2142 -----------------KEQYEALQEETRV----AQKELEEAVTSALQQETEKSKAAKEL 2180
++Q + LQE + + K+L+E+ TS + E+ A+
Sbjct: 1676 FLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKIVAERQ 1734
Query: 2181 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 2240
E K+K+ + D +T Q L G ++ A DG + + + K
Sbjct: 1735 QEYKEKLQGICDLLT-------QTENRLIGHQE---------AFMIGDGTVELKKYQSKQ 1778
Query: 2241 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK---EQ 2297
++ + M+ Q L +N + FL ++G L+ E++ +++QKL E K EQ
Sbjct: 1779 EELQKDMQGSAQALAEVVKN-------TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQ 1831
Query: 2298 YSTSLAQSEAELKQVQT--LQDELQKF-----LQDHK----EFESWLERSEKELE---NM 2343
+ QS+ EL +V T +++E +K L++ K WL +K+ E
Sbjct: 1832 LNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTK 1891
Query: 2344 HKG-------------------------------------GSSPETLPSLLKRQGSFSED 2366
HK G++ E L ++ + E
Sbjct: 1892 HKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEK 1951
Query: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
+IS + T S Q +L+ + + +E ++ +K+ LK E A K +L
Sbjct: 1952 IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE-LKVHYETALAESEKKMKL- 2009
Query: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
+ L + +F + W+Q E +E L + A D L +L K E++
Sbjct: 2010 --THSLQEELEKFDADYTEFEHWLQQSEQELENL--EAGADDINGLMTKLKRQKSFSEDV 2065
Query: 2487 AEHQ-------VPVEKLQKVARDIMEIEG---EPAPDHRHVQETTDSILSHFQSLSYSLA 2536
H+ + ++ + A+ + +G + + HR VQ D F+SL
Sbjct: 2066 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 2125
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS---SLSSGVIQEALATNMKL 2593
+ L+ + + Q +++ LL + E K +S ++ +Q L L
Sbjct: 2126 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT-ASKHLSEPIAVDPKNLQRQLEETKAL 2184
Query: 2594 KQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSL 2651
+ I+ Q+ ++E ++ ++ S A +Q L ++ R+E L E+ L
Sbjct: 2185 QGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 2244
Query: 2652 KKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED----QQ 2707
+ L ++ + ++ +M N L Q + T Q I N+ +E +Q
Sbjct: 2245 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNST-ALQDIISKNIMLEQDIAGRQ 2303
Query: 2708 ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEF 2767
+++ + V + Q ++++L F+E KE + +++ F
Sbjct: 2304 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2363
Query: 2768 RKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS 2827
L Q +L+ ++ TE + K++ + ++++ ++ +E
Sbjct: 2364 ENLSEKLQTFLETKTQAL--TEVDVPGKDVTELSQYMQESTSEFLEHKKHLE-------V 2414
Query: 2828 LENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGV 2887
L +L+ EI+ S G LPS D + ++++ K++++
Sbjct: 2415 LHSLLKEIS---SHG-----LPS---------------DKALVLEKTNNLSKKFKEMEDT 2451
Query: 2888 LHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKA 2947
+ E++E++ + +++ S+ W+ +E K + + E + E K
Sbjct: 2452 IKEKKEAVTSCQEQLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKK 2508
Query: 2948 FLAELEQNSPKIQKVKE---ALAGLL--VTYPNSQEA-------------------ENW- 2982
+ +P+IQKV +L L+ VT P A E W
Sbjct: 2509 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2568
Query: 2983 -------KKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL--MEKEL 3033
KK +++ +E + + +L S L Q S + WL M K
Sbjct: 2569 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2628
Query: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQV 3093
P D + Q +Q K FEA +Q+ + + LT + + T +
Sbjct: 2629 TKWQQTPAPTDTEAVKTQVEQ----NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2684
Query: 3094 ---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 3150
++ L I+ KW EL R +++++ TQ+Q + L + + +SV
Sbjct: 2685 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2744
Query: 3151 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQ-YLKDELKKRLET 3209
+S P + Q ++ + + + ++ + GE L+ +K++L
Sbjct: 2745 PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2804
Query: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
V L +DR + + A+ + Q+Q + L L D ++ + + +S + +
Sbjct: 2805 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2864
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
QL+ ++ ++ + Q +V A E L V K L QL + ++++ +
Sbjct: 2865 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2924
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAML 3389
K + L+ + ++Q D W++ K + ++ + + SL++
Sbjct: 2925 KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDF 2984
Query: 3390 NEVEKRRSLL--EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEE 3447
++ +S + + + ++L+ + +++ ++ + I N D ++++ + L+E
Sbjct: 2985 SKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 3044
Query: 3448 MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVD 3507
++ +++E + + ++ ++ LE A ++ KL++ Q+ + V+
Sbjct: 3045 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 3104
Query: 3508 YLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR 3567
L N L+ D + + + Q+ V ++++S +EN + +F
Sbjct: 3105 LLNNTANSLLSVCE--IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEV 3162
Query: 3568 VREMFSQLADLDDELDGMGAIGRDTDS------LQSQIEDVRLFLNKIHVLK-----LDI 3616
+E QL ++LD ++G S LQ+Q + ++ +++ + K L +
Sbjct: 3163 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVV 3222
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK 3676
EAS++ +GT D+L ++E + ++ L+++ + LE L + F
Sbjct: 3223 EASDS--------KGTSDVL---LQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNT 3271
Query: 3677 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
++ + ++ VG + E + +Q K F K +++ L N + +
Sbjct: 3272 IREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK-KLEALMASNDNANKTCKMM 3330
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796
+ + D+ G++ D+E ++ + N L + R Q++ + +F L+ L
Sbjct: 3331 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQ 3390
Query: 3797 DTEELIANQKPPSAEYKVVKAQIQEQKLLQR----LLDDRKATVDMLQAEGGRIAQSAEL 3852
EE +Q P E + + Q+ K+ Q+ L ++ V+ L G I +A+
Sbjct: 3391 KAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ--GLIQSAAKS 3448
Query: 3853 ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLA 3912
+ + L+ + +RW L K A R QL++ L+ +F + E + ++ TE+ +A
Sbjct: 3449 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3508
Query: 3913 NSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID 3972
N +P + ++ QI K L+ +++ + V + G+ +++ PA++ + +++
Sbjct: 3509 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3568
Query: 3973 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV 4032
L +R+ + ++ + L+ A+ F E + WL +E +L + +
Sbjct: 3569 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3628
Query: 4033 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 4092
L Q A H AL ++I+N K++ QA+ GQ+L ++ E+ ++Q KLD + Y +I
Sbjct: 3629 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688
Query: 4093 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKEL 4152
S L+QA A F EL WL EV ++L+ Q + E + + Q + L
Sbjct: 3689 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3748
Query: 4153 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGL----DKLVSDANEQYKLVSDTIGQRVD 4208
+++++ L V++ LEL+ + + DKL + +YK ++
Sbjct: 3749 QEDIL---LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA-IKARYKDITKLSTDVAK 3804
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
++ A+Q +++ + W+ + + +L++ L+ ++ + K + +
Sbjct: 3805 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3864
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
K +D L S + + L++ ++Y +S +++ ++ A + Q
Sbjct: 3865 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3924
Query: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 4388
F + + WI ET + L ++ +Q Q + + I HK ID L+K G
Sbjct: 3925 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3984
Query: 4389 PQ-LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ + + EE + +++K K Y I + +R L L+ A S Q E ++++ P
Sbjct: 3985 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 4044
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
L +++ S+L P L E + +R+ +++ + + +P + + + G +L+ S
Sbjct: 4045 LTETQSIISQLPAPAL---EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP 4101
Query: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567
G IQ+K + IK ++R + + + + +F + +L +++
Sbjct: 4102 G-----EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4156
Query: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK--- 4624
+ + S + IK+Q+ + + + + L E ++ G ++I G T+K
Sbjct: 4157 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4216
Query: 4625 -PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683
V+ +D+M WEN++ +ER KL D M+ A ++ ++ + +T + +
Sbjct: 4217 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4276
Query: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
G D + VK Q + + E+ Q E++ + + G ++ A E D+ I+++ + E
Sbjct: 4277 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI-AACGEPDKPIVKKSIDE 4335
Query: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
L W++L + R KLE A+ A Q+Q L+ + W+ L + PI D + +
Sbjct: 4336 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4395
Query: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLES-SAGDDASSLRSRLEAMNQCWESVLQ 4862
+ ++ + K++ Q +E +N LL+ + D +++ L + W+S+ +
Sbjct: 4396 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4455
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4922
+ R+ +L+ L F +++ L LT E LS KP GG P+ +L H L
Sbjct: 4456 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4515
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
+ + A + T + ++K L+ S + + +L Q+W V K E+RK +L+
Sbjct: 4516 QNDVLAHQSTV-EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4574
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
AL A F +++ WLT E+ L + P + T Q+ H A +
Sbjct: 4575 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4634
Query: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
L Q G Q+ K I + +++ +WE V + ER L++A A +FH
Sbjct: 4635 YKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4694
Query: 5103 AWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL 5162
+ + I+WL AE L+ S D + Q+ +HK F + + +TG L
Sbjct: 4695 SLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL 4754
Query: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
K + +D + N L V+ +W+ V + VER L++A + QF +A L++WL
Sbjct: 4755 KYFS-QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4813
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS--RDDT 5280
+ E L + + D D + + HK FQK LG + R+GR L E + DD
Sbjct: 4814 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4873
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
+ L EL +WDT+C SV +Q++LE+AL + F D + L++WL E L
Sbjct: 4874 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4933
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
+ D + + +LID HK F K++ ++ V + ++ D + +K + +
Sbjct: 4934 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKVQMQELS 4992
Query: 5401 ARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRV 5460
R+E V + Q RLE AL + ++ LL W+ AE TL R +P + D +
Sbjct: 4993 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTL--RFHGVLPDDEDAL 5050
Query: 5461 KALIAEHQTFMEEMTRKQPDVDRVT 5485
+ LI +H+ FM+++ K+ ++++ T
Sbjct: 5051 RTLIDQHKEFMKKLEEKRAELNKAT 5075
Score = 442 bits (1137), Expect = e-123
Identities = 584/3078 (18%), Positives = 1246/3078 (40%), Gaps = 292/3078 (9%)
Query: 1795 QNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDL 1854
Q TR L ++ + L L + N+E K+ + LN LQD++ + +LE+++
Sbjct: 2245 QITLTRSLSVQ--DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2302
Query: 1855 TTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914
+ ++ E V + + + +L+ K+L S S L +
Sbjct: 2303 QSSINAMNEKVKKFM----ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL-- 2356
Query: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC-LQQY-EDLKQP 1972
KTKV E + L+ ++ K L +E+DV ++ L QY ++
Sbjct: 2357 --KTKV----ELFENLSEKLQTFLETKTQAL------TEVDVPGKDVTELSQYMQESTSE 2404
Query: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032
E K L+ L + E + P +L N L + F++ +E T
Sbjct: 2405 FLEHKKHLEVL----HSLLKEISSHGLPSDKALVLEKTNNLSKKFKE-MEDTI------- 2452
Query: 2033 GHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQS 2092
E++ V + Q+Q + ++ L SW+ + + + Q +DL K+
Sbjct: 2453 -----KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLE 2504
Query: 2093 DLKDLQD----------DIQNRATSFATVVKDI-------------------EGFMEENQ 2123
D K LQ+ + N S ++ + EG +
Sbjct: 2505 DTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2564
Query: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183
+ + LT++++ + YE L + EL + S LQ+ E+S
Sbjct: 2565 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL-SKLQKAQEES--------- 2614
Query: 2184 KKKIDALLDWVTSVGSSGGQ-LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 2242
A++ W+ + + + T P + +E+ + VN+ E DK
Sbjct: 2615 ----SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2670
Query: 2243 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ------QKLGELKE 2296
E+++ T A P +QML Q+L +L
Sbjct: 2671 LTELLEENPD------------TPEA------------PRWKQMLTEIDSKWQELNQLTI 2706
Query: 2297 QYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSL 2356
L +S L Q QT++ +L++ WL E + + P L +
Sbjct: 2707 DRQQKLEESSNNLTQFQTVEAQLKQ----------WLVEKELMVSVLGPLSIDPNMLNTQ 2756
Query: 2357 LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYT 2416
++ ++ + K +T +GQ +L + G++PS + +VK++L T+++
Sbjct: 2757 RQQVQILLQEFATRKPQYEQLTAAGQGILS-----RPGEDPS-LRGIVKEQLAAVTQKWD 2810
Query: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
+L + + ++ + + Q+Q+ SL + + + L+ V++ P + +QL
Sbjct: 2811 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA--VSTHPDAMNQQL 2868
Query: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
T +++++E+ + + ++ Q + D+ + E + + IL F+ +
Sbjct: 2869 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYL-KAELSRQLEGILKSFKDVEQKAE 2927
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
LQ A A S Q+ + ++ S V++ + + +
Sbjct: 2928 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2987
Query: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
+ Q E T + + A LQ +L + ++ Q +E+E+ LK+ L
Sbjct: 2988 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 3047
Query: 2657 QA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2712
+A E E L + + N + + + + + +++ L EM+ ++
Sbjct: 3048 KALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE--NSIAKLKSLQKEMDQHFGMVEL 3105
Query: 2713 LEHLVTE-LSSCGFALDLCQHQDR-------------------VQNLRKDFTELQKTVKE 2752
L + LS C ++ +++ ++N+ + F E Q+ KE
Sbjct: 3106 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3165
Query: 2753 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812
++ +EQLD L Q + + + + S+ A L+ Q++ K L D
Sbjct: 3166 SKRQLQCAKEQLDIHDSL--GSQAYSNKYLTMLQTQQKSLQA--LKHQVDLAKRLAQDLV 3221
Query: 2813 -----SKG----------------TLVEEINCKGTSLE----------NLIMEITAP--- 2838
SKG TL ++++ K + LE N I E+ +
Sbjct: 3222 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 3281
Query: 2839 -----DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2893
DS G ++ ++ + K L + + N K K+ E
Sbjct: 3282 FDDELDSMAPVGRDAETLQKQKETIKAF--LKKLEALMASNDNAN-KTCKMMLATEETSP 3338
Query: 2894 SLQAILNRMEEVHKEANSVLQWLESKEE----VLKSMDAMSSPTK--------------- 2934
L I +E + K+ N +L +++EE +K ++ S K
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3398
Query: 2935 -------TETVKAQAESNKAF-LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ 2986
TET+ Q K F E+E K Q V GL+ + S + +
Sbjct: 3399 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 3458
Query: 2987 EELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPN 3046
+++N+RW+ + R QL+E+ H FQ A L W+++ E ++ P S +
Sbjct: 3459 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3518
Query: 3047 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT--GPGDVSLSTSQVQKELQSINQKW 3104
++ AQ Q+ + + + + R+ E + + I T P D ++ K+L ++ +W
Sbjct: 3519 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD----KVKILKQLSLLDSRW 3574
Query: 3105 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 3164
L +K +R+ Q++ V + Q+ E L+ L+E + + +RL I TQ +++Q+
Sbjct: 3575 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3634
Query: 3165 ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADR 3224
+ + D+ + + +A ++ L VL + KD ++ +L+ + +++ + R
Sbjct: 3635 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED-KDMVQSKLDFSQVWYIEIQEKSHSR 3693
Query: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 3284
LQ AL + + F + EL WL++ + +K E L Q E Q+ +
Sbjct: 3694 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3753
Query: 3285 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 3344
+ + + G LL G+E +Q++L +K +++++K + D L+ +Q
Sbjct: 3754 LRKQNVDQALLNGLELLKQT-TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3812
Query: 3345 AQKYQWHVEDLVPWIEDCKAKMSELRV-TLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 3403
A++ E+L W++ + ++ L + + +R K + E + ++LL+ LN
Sbjct: 3813 ARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3872
Query: 3404 SAADILINSSE-ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREF-QESFKN 3461
+ L+ +G+ A N+ V++ + K ++ R ++F Q +
Sbjct: 3873 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3932
Query: 3462 IEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA-QQEVLQALEPQVDYLRNFTQGLVEDA 3520
+ E K + + D Q ++ L+ + E+L+ + D +++ + + A
Sbjct: 3933 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK--IMTA 3990
Query: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
+ + + + + + + Q + + +E + QF E++ L +
Sbjct: 3991 CSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQS 4050
Query: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE---EEGTLDLLG 3637
+ + A + ++L+ Q E+ R I K I+ +LE EG
Sbjct: 4051 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG----FS 4106
Query: 3638 LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV 3697
++ + A + ++ E K R L+ + + F+ K+ + ++ E +
Sbjct: 4107 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 4166
Query: 3698 GTEVEIINQQLADFK--MFQKEQVDPLQMKLQQVNGLGQGLIQSAG---KDCDVQGLEHD 3752
EVE I +Q+++ K E++ PL L+Q G+ +I +G KD + ++
Sbjct: 4167 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQDK 4223
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812
++++ W ++ V +R A+L + + KF L+ + DT++ I + + P +
Sbjct: 4224 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4283
Query: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872
VVK Q + + ++ +D + +D++ G + + D+ + ++ L S W L
Sbjct: 4284 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4343
Query: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI---- 3928
R +LE+ + A Q+ + + + D++ + KLA+ P+GT ++QQI
Sbjct: 4344 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4403
Query: 3929 -IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+ +A ++ IE + HQA + L +T +++ + + + L+ + +++R
Sbjct: 4404 QFKSEAYQQQIEMERLN-HQAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4459
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
+ L+ AL F E+L WL E LS + + A H L ++
Sbjct: 4460 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107
+ + V+ K G L++ + GEE +Q KL+ + R+ ++ + + + L+ A +
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4579
Query: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM----EHRLVL 4163
A F E+L WL + E L S P G +P+ + Q + EV
Sbjct: 4580 AKGFHGEIEDLQQWLTDTERHLLAS---KPLG-GLPETAKEQLNVHMEVCAAFEAKEETY 4635
Query: 4164 DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 4223
++ + + +L P A +D+ +++ E+++ V + +R +++ A+ + ++ +
Sbjct: 4636 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4695
Query: 4224 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF 4283
+ W+ + ++ L L D Q+ K F+ ++ H++ + EL + +
Sbjct: 4696 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4755
Query: 4284 GTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEET 4343
++ +++ S+ ++E + ER L+ A+ QF E + +L W+EE+
Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4815
Query: 4344 RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN--PEEGEM 4401
+ A D ++++ Q + ++ ++S+ D + G LKE ++
Sbjct: 4816 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4875
Query: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
+++ + + + I + +R L+EA+ S Q T D ++ +++ L + +L
Sbjct: 4876 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT---DALQALIDWLYRVEPQLAED 4932
Query: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521
+ ++D + I ++K+ EL K S +ALKR ELI +G+ D + ++Q
Sbjct: 4933 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQ-- 4987
Query: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4581
+ ++ WE + A + ++ + L AE+F + ALL + + + + D
Sbjct: 4988 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 5047
Query: 4582 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4641
++ ++ + ++ + EL +G ++ C ++ I + +E +
Sbjct: 5048 DALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 5107
Query: 4642 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD--NTVIKLCTMPPVGTDLNTVKDQLNE 4699
K+ ++L A+ + Q+ L+A+ WL T + + ++ VK + E
Sbjct: 5108 LAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5167
Query: 4700 MKEFKVEVYQQQIEMEKL 4717
+ F E+ ++Q +++K+
Sbjct: 5168 HQTFMEEMTRKQPDVDKV 5185
Score = 404 bits (1039), Expect = e-111
Identities = 676/3612 (18%), Positives = 1415/3612 (39%), Gaps = 437/3612 (12%)
Query: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
++ L+K+ QN +++ +DL +WV + + L RT SDL
Sbjct: 763 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 809
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149
++ ++N + +++ E ++E K+S ++TA EKLH+ + QY L
Sbjct: 810 PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 866
Query: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201
+R ++ L+ V+ A + E E+ + A + +E I D+ +
Sbjct: 867 NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 926
Query: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258
Q N+ +++++ L + A T + Y Q Q C+ ++ +E +
Sbjct: 927 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 986
Query: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317
+ F N E L+ ++ +YS + S +L+ VQ +
Sbjct: 987 EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 1030
Query: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368
E ++ LQ + + +++ ++ + P +K + + I
Sbjct: 1031 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 1090
Query: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421
SH+ + ++ +G + + F KE ++ N ++ + ++ T H
Sbjct: 1091 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 1146
Query: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480
SH+NM + +H N D ++A + A+++ +L PG Q+ L+ +
Sbjct: 1147 -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 1191
Query: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540
E+ E + DI ++E E ++ QE S AER
Sbjct: 1192 SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 1237
Query: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593
Q +SV S +++I +N E + + + + + ++ L ++ KL
Sbjct: 1238 -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1290
Query: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649
K+++ R K L T + F + A S++ L+ +L V Q Q+ +K
Sbjct: 1291 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 1350
Query: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709
++ +L + E L + + + ++A N +I + +++ E++++++
Sbjct: 1351 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 1406
Query: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
LE + + + LD H+++ L + + + + R +D
Sbjct: 1407 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1466
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
+ L +R W+++ E + K E Q E+ K+L + LV E
Sbjct: 1467 GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1518
Query: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874
I K + ++ T D + +T + V S S V I +
Sbjct: 1519 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1578
Query: 2875 SDVNLKYEKL-----------GGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2923
D+ +Y L G L +E +++ +E ++A + +W+ + + L
Sbjct: 1579 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1638
Query: 2924 KSMDAMSSP-------------TKTETVKAQAESNKAFLAEL--EQNSPKIQKVKEALAG 2968
K + P TK E + ++ + FLA+ + + ++++ +
Sbjct: 1639 KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1698
Query: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ------------LEESASHLAC 3016
L +Y N +E+ K++QE S + E VA ++Q L ++ + L
Sbjct: 1699 LQESY-NLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIG 1757
Query: 3017 FQAA-----------ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEAR 3065
Q A + Q + ++K++ + N N K+ + + +E +A
Sbjct: 1758 HQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1817
Query: 3066 RQQH--------EQLNEAAQ-------GILTGPGDVSLSTSQVQKELQSINQK------W 3104
+Q EQLN A+ ++T K+L+ K W
Sbjct: 1818 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1877
Query: 3105 VELTDKLNSRSSQIDQAIVK--STQYQE--LLQDLSEKVRAVGQRL--SVQSAISTQPEA 3158
+ DK + R+ + +++ T +QE + E+ G L V + T E
Sbjct: 1878 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1937
Query: 3159 VKQQLEET----SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 3214
+ QQ ++ +I S + + + AQ L ++ QYL E K++L+ L
Sbjct: 1938 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQG-----QYLSPEEKEKLQKNMKEL 1992
Query: 3215 QGLEDLAADRINRLQAALASTQQFQQMFD----ELRTWLDDKQSQQAKNCPISA-KLERL 3269
+ + A + S Q+ + FD E WL + Q+ +N A + L
Sbjct: 1993 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE-QELENLEAGADDINGL 2051
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS-----------VPPGEEKRTLQNQLV 3318
++L+ + F + + H G I G +L + V R +Q +L
Sbjct: 2052 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 2111
Query: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE---LRVTLDP 3375
+ + L K + LKD + K Q Y+ L+ ++ C+A S+ + +DP
Sbjct: 2112 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2171
Query: 3376 VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI----------NSSEADEDGIRDEKA 3425
L+ L +KA+ ++ ++ +E L A++L+ N + D I
Sbjct: 2172 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 2231
Query: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALGSQAC 3484
++++++ E+LQ + L E + N+E + K Q ++ ++ Q
Sbjct: 2232 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL---KEQGQVPLNSTALQDI 2288
Query: 3485 SNKNL---EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL 3541
+KN+ + + +Q + A+ +V T D S AS L + + F
Sbjct: 2289 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETT--------DPSTASSLQAKMKDLSARFS 2340
Query: 3542 EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIED 3601
E + ME + E+F L ++ LQ+ +E
Sbjct: 2341 EASHKHKETLAKMEELKTKV--------ELFENL----------------SEKLQTFLET 2376
Query: 3602 VRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQE 3661
L ++ D+ + +E T + L K+ LE L+ +++ G +
Sbjct: 2377 KTQALTEV-----DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 2431
Query: 3662 QLELTLGRVEDFYRKLKGLND--------ATTAAEEAEALQ--------WVVGTE----- 3700
L L + + +K K + D T+ E+ +A Q W+ T
Sbjct: 2432 --ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI 2489
Query: 3701 ------VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL----------------IQ 3738
E + + L D K Q E+ ++Q+VN G L ++
Sbjct: 2490 VQPSFGAEDLGKSLEDTKKLQ-EKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVK 2548
Query: 3739 SAGKDCDVQG----------------LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
S G + +G ++ DM +I+ + L + +IA+L L
Sbjct: 2549 SGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQ 2608
Query: 3783 KFQDALEPLLSWLADTEELIA--NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
K Q+ ++ WL + Q P + + VK Q+++ K + L V L+
Sbjct: 2609 KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2668
Query: 3841 AE-GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3899
+ + ++ + + + L ++S+W EL RQ++LE+ QF
Sbjct: 2669 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2728
Query: 3900 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL- 3958
+ +L E ++ P+ + Q + + L ++ Q GQ + S
Sbjct: 2729 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRP 2788
Query: 3959 -TSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
P+ +G++ E++ ++ ++ + + + +DQA+ + + + + L++++
Sbjct: 2789 GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLD 2848
Query: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTTGEEVL 4074
+KLSS D +++Q + +EI KK IK QAL L EE L
Sbjct: 2849 NKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQ----IKVAQALCEDLSALVKEEYL 2904
Query: 4075 L--IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+ +L+GI + D+ + ++ L+ A + +FQ + WL +EE S
Sbjct: 2905 KAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKS 2964
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA 4192
S + + + K+ K + + + LL + L ++
Sbjct: 2965 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTI 3024
Query: 4193 NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL----MALGPIRLEQ 4248
+ + + +R +++ +++++ +Y++ + W+ + + L L P E
Sbjct: 3025 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP--AEG 3082
Query: 4249 DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 4308
+ + A+L K+ ++ +H ++ L + + + C E K V+ ++ +SLIQ+ + +
Sbjct: 3083 ENSIAKL---KSLQKEMDQHFGMVELLNNTANSLLSVC-EIDKEVVTDENKSLIQKVDMV 3138
Query: 4309 S-LLNSERYARLERAQVLVNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQ 4364
+ L+S+++ LE +F E +E ++ E + L S A ++ L Q
Sbjct: 3139 TEQLHSKKFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3197
Query: 4365 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
+ + L+ +H+ + K L ++ + + V + + ++ + ++V ++
Sbjct: 3198 TQQKSLQ--ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3255
Query: 4425 LALDEAVS-----QST------QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 4473
L+ + Q+T Q EF D+++ M + + + I A + K+
Sbjct: 3256 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3315
Query: 4474 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4533
++ N +A K A + +L+G + D + +K+ LD
Sbjct: 3316 LMASNDNA----NKTCKMMLATEETSPDLVGIKR--DLEALSKQCNKLLD---------- 3359
Query: 4534 ARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET 4593
RA+ RE + ++ E+F+ + ++ ++ G++ I QQ+ +
Sbjct: 3360 -RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 3418
Query: 4594 I-KEETDGLHEELEFIRILGADLI-FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4651
KEE + L + + + LG LI A T + +D++N W+ LNK +R +
Sbjct: 3419 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 3478
Query: 4652 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4711
L++A+ ++QD L+++ W+ +T + P + VK Q+ E K + + ++
Sbjct: 3479 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRK 3538
Query: 4712 IEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771
+E + +GE + A + D+ I + L+ L WE L K R +LEG + Q
Sbjct: 3539 STVEVIKREGEKIATTA-EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3597
Query: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
F LE L WLT E+ L PI +E ++A+H L++D++ H + G
Sbjct: 3598 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3657
Query: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L S+ +D ++S+L+ + + +K+ R + LQ L A+ F + + +
Sbjct: 3658 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 3717
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + +LS E +Q L + +++ +Q L G L LL +
Sbjct: 3718 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNG-LELLKQTTGD 3776
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
+ + ++ ++ ++ + LE+AL LA ++ +E WL E L +
Sbjct: 3777 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL-L 3835
Query: 5012 ASPPSLILNTVLSQIE-EHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLV 5070
+ ++ SQ + K E ++ + L++ + L L + ++ ++
Sbjct: 3836 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVA 3895
Query: 5071 SVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
R+ V ++ +D A R++QF +A + W+ + E L S +I + D+
Sbjct: 3896 EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3955
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
QL K F + + + D +++G + E+ Q + L +V +DT+C
Sbjct: 3956 TSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM-TACSEEEKQSMKKKLDKVLKNYDTIC 4014
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
+ ER +LE A QF + + L WL + + +++ + + + + H+
Sbjct: 4015 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQ 4074
Query: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
++ + + + + ++G +L+E S + ++ + T + + + + L++
Sbjct: 4075 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 4134
Query: 5311 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
A+ Q+ F D + +LE L + LR ++ + E ++ I +K +E+ +
Sbjct: 4135 AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLY 4194
Query: 5371 NSAVAMGEVILA 5382
+ GE ++A
Sbjct: 4195 ETLKQRGEEMIA 4206
Score = 381 bits (978), Expect = e-104
Identities = 610/3185 (19%), Positives = 1269/3185 (39%), Gaps = 392/3185 (12%)
Query: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
+SSLL + + + + + ++ LL + E++ L+ + S D+
Sbjct: 768 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 809
Query: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2653
+S LE + V R +E +S+ + + K++E+ Q L L EK ES K
Sbjct: 810 PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 864
Query: 2654 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2701
LL + E L F+ + L N+ +++ + + N+
Sbjct: 865 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 924
Query: 2702 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2735
E++ ++EN+ +++ + +L + + L LCQ ++
Sbjct: 925 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 984
Query: 2736 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792
N K+ T+ + +K+ + SC ++ KL Q+ ++E E + T
Sbjct: 985 YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 1043
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2848
+ K I LK D K ++ + C +E I + + A +S ++
Sbjct: 1044 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 1103
Query: 2849 PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2908
G+ + T + D+++ ++ Q +L E H
Sbjct: 1104 SPTGNEAMVPSVCFTVPPPNKEAVDLAN-------------RIEQQYQNVLTLWHESHIN 1150
Query: 2909 ANSVLQW--LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL 2966
SV+ W L ++ + +++ + S T Q SN L ++ + + +
Sbjct: 1151 MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN---LQSRFEDFLEDSQESQVF 1207
Query: 2967 AGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 3026
+G +T + + QE L S A + + EES +L + +LR
Sbjct: 1208 SGSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRL 1257
Query: 3027 WLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086
E L+ + PL D + F + E E +++ E+L + G +T +
Sbjct: 1258 ENCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEE 1310
Query: 3087 SLSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL----- 3132
S + + ++ + + +N S+ ID+ ++K+TQ E L
Sbjct: 1311 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 1370
Query: 3133 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 3192
L E+ + + ++++ IST +KQ E E R L+ E+++A+ + DE+
Sbjct: 1371 TKLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 1426
Query: 3193 LIGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 3251
E+ L D K++ + + Q + +R+ L+ S + ++ + L W+
Sbjct: 1427 TYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ- 1485
Query: 3252 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 3311
++E Q ++QEN+ E +
Sbjct: 1486 -------------QVETTQRKIQENQP-----------------------------ENSK 1503
Query: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 3371
TL QL + K E+ K QS++ +C + A++Y V+D +A + +
Sbjct: 1504 TLATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1559
Query: 3372 TLDPVQLESSLLRSKAMLNEVEKRRS--------LLEILNSAADILINSSEADEDGIRDE 3423
+ PV+ + ++ E R+ + + + A D L E +E + +E
Sbjct: 1560 S--PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL-KRLEEEEKSLEEE 1616
Query: 3424 K-------AGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF 3476
K + + + +++ L+ + + + + E ++++ A +++F
Sbjct: 1617 KKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLF 1676
Query: 3477 DALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3536
A +++ +L Q + LQ Y F++ L + + + + VA
Sbjct: 1677 LAKHGDKMTDEERNELEKQVKTLQE-----SYNLLFSESLKQLQESQTSGDVKVEEKIVA 1731
Query: 3537 --QQEFLEVKQRVNSGCVMMENKLEG------IGQFHCRVREMFSQLADLDDELDG---- 3584
QQE+ E Q + EN+L G IG +++ S+ +L ++ G
Sbjct: 1732 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1791
Query: 3585 MGAIGRDTDSLQSQ------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
+ + ++T++ + ED L K++ K+ E + +E + +
Sbjct: 1792 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1851
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVE-DFYR---KLKGL----------NDAT 3684
K E E + K E K + E L L V+ D R K K + D
Sbjct: 1852 KEETEKV--AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGK 1909
Query: 3685 TAAEEAEA---------LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3735
+A E + + VGT E +NQQ K Q E++ + Q
Sbjct: 1910 SAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQSAQV 1968
Query: 3736 LIQSAGKDC---DVQGLEHDMEEINARWNTL---NKKVAQRIAQLQEALLHCGKFQDALE 3789
L++ G+ + + L+ +M+E+ + T ++K + LQE L KF
Sbjct: 1969 LLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---EKFDADYT 2025
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
WL +E+ + N + + + + +++ QK + K + + G R+ ++
Sbjct: 2026 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 2085
Query: 3850 AE------------LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA 3897
A+ A ++ +L+ R+ L SK L+D++ + + + +
Sbjct: 2086 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 2145
Query: 3898 EPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955
+ L E + SEP+ +Q+Q+ KAL+ I + V + K + L
Sbjct: 2146 CGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 2205
Query: 3956 SSLTS---PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW 4012
PA+ + + +D + RY ++ + L L+ + + E+L+W
Sbjct: 2206 LDARGSLLPAKNDI-QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2264
Query: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
+ VE L L + ++ L ++I R+ +++ + + ++ T
Sbjct: 2265 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPST 2324
Query: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+Q K+ + R+++ + + L +E+ + F++ E+L +L + L
Sbjct: 2325 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE- 2383
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL-VPWRAREGLDKLVSD 4191
G+ + + Q +E E +EH+ L+ ++ + + + +P L+K ++
Sbjct: 2384 --VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNN 2440
Query: 4192 ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-- 4249
++++K + DTI ++ + + + ++ ++ + +W+ ET +K+ + P +D
Sbjct: 2441 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2500
Query: 4250 ---QTTAQLQVQKAFSIDIIRHKD----SMDELFSH------------------RSEIFG 4284
+ T +LQ + + I+ + S+ L S E
Sbjct: 2501 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2560
Query: 4285 TCGEE-----QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
T EE T +++ + YE + LL ++ A L + + E + W
Sbjct: 2561 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2620
Query: 4340 IE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL-- 4394
++ +T Q P+P D E ++ Q E+ + AE K +++K+ ++ +L EL
Sbjct: 2621 LQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFE---AELKQNVNKVQELKDKLTELLE 2676
Query: 4395 -NPEEGEMVEEKYQKAE--NMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
NP+ E K E + + ++ + R L+E+ + TQ +++ L
Sbjct: 2677 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2736
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
E + S L + P ++ R+ + + E +P +E L G+ ++ R G D
Sbjct: 2737 ELMVSVLGPLSIDPNMLNTQRQQV---QILLQEFATRKPQYEQLTAAGQGILSR-PGEDP 2792
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
L ++++L + W+ + + +R + + ++ + +L + D + +
Sbjct: 2793 SLRG-IVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKL 2851
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADL-IFACGETEKPEVRKS 4630
+ P + QQ+E A+ +K+E ++++ + L DL E K E+ +
Sbjct: 2852 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2911
Query: 4631 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL 4690
++ + +++++ + + ++ L+ A ++ Q+Q + WLD + P+ L
Sbjct: 2912 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2971
Query: 4691 NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN 4750
+ ++ + + K+F + Q EK +GE +L K T +++ ++ L +K W+
Sbjct: 2972 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK-TQGSEKAALQLQLNTIKTNWDT 3030
Query: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
+++ R++KL+ +L +++ +E L W+ + L+ + DP E +AK
Sbjct: 3031 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKL 3089
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
L+ ++ H VE +N N LL D E + +S++QK + +Q
Sbjct: 3090 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDK--------EVVTDENKSLIQKVDMVTEQ 3141
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQ----- 4925
L S + + ++F SK + + A+EQLD H L SQ
Sbjct: 3142 LHSKKFCLENMTQKFKEF----------QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 3191
Query: 4926 ----LKAKEETYNQLLDKGRL-------MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKM 4974
L+ ++++ L + L +++ DS S V + Q+ +S ++
Sbjct: 3192 YLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3251
Query: 4975 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
+E+ S LE L FQN+++E + + L+ +P T+ Q E K F
Sbjct: 3252 DEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK 3311
Query: 5035 EVNAHRDQIIELDQTGNQLKFLSQ-KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
++ A ++T + + D+V IK L ++ + K++ R+ R ++
Sbjct: 3312 KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 3371
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK----TLGGKQ 5149
KR ++F+ K+ L+ AE H +S+ + + + I QL+ K FQK L GKQ
Sbjct: 3372 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3431
Query: 5150 PVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
+ G+ L + +Q L++ L +V +W T+ K +R +L+EALL G+
Sbjct: 3432 QDVNW---LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3488
Query: 5210 FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 5269
F DAL++L+ W+ E +A +P + +V + K+ Q+ L R TV+V+KR G
Sbjct: 3489 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3548
Query: 5270 RELIENSRD-DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 5328
++ + D + QL L +RW+ + + ++ +LE A+ F +T+ L EW
Sbjct: 3549 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3608
Query: 5329 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 5388
L+ E+ L + L+ I HK + ++ AV++G+ + + +
Sbjct: 3609 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED 3668
Query: 5389 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI---------- 5438
++ + + + E+ + + L+ AL E EL+ W+
Sbjct: 3669 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKL 3728
Query: 5439 ------------QWAETTLIQRDQEPIPQNIDR--VKALIAEHQTFMEEMTRKQPDVDRV 5484
Q +E ++Q D QN+D+ + L QT +E+ Q ++ +
Sbjct: 3729 SVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 3788
Query: 5485 TKTYK 5489
YK
Sbjct: 3789 KARYK 3793
Score = 60.8 bits (146), Expect = 4e-08
Identities = 181/985 (18%), Positives = 364/985 (36%), Gaps = 178/985 (18%)
Query: 4666 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4723
+Q + +W+D ++L G+DL +V+ L K +E ++ ++ K++
Sbjct: 786 VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 844
Query: 4724 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4783
K T E H E+ K+ + E L L F + WL
Sbjct: 845 APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 893
Query: 4784 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4839
EE ++ D +A+ H L ++ + +++V + +LL +
Sbjct: 894 NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 948
Query: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4894
++ + AM W +LQ + EQ ++ + F+ E D+L L +
Sbjct: 949 -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 1007
Query: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4953
+ S L + +E ++ EL + T L+ K + ++ L +S
Sbjct: 1008 RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 1063
Query: 4954 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4981
KT + + KW V+S E
Sbjct: 1064 LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 1123
Query: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041
+EA++LA + Q++ N LTL +S + + + NE++ R
Sbjct: 1124 KEAVDLANRIE---QQYQNVLTLWHES-----------HINMKSVVSWHYLINEIDRIRA 1169
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKRA 5097
+ +K + + ++ NL QSR+E ++ S E G + K
Sbjct: 1170 SNVA------SIKTMLPGEHQQVLSNL----QSRFEDFLEDSQESQVFSGSDITQLEKEV 1219
Query: 5098 ---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTLG 5146
KQ+++ K + E ES + L + N D++ Q+ E
Sbjct: 1220 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE------ 1273
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ--------- 5197
+ ++++ R + E+ L ++ ++L + LG + +K + ++
Sbjct: 1274 -RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 1328
Query: 5198 ----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVMN 5243
+ + S ++D L+ + + L K+ E +L E++ V D + + N
Sbjct: 1329 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 1388
Query: 5244 LMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELSTR 5293
L+ K ++ E+ ++ L K E+ + ++ D W K + +L R
Sbjct: 1389 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 1448
Query: 5294 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSL 5352
W V ++ LE K + +RDT H L +W+ + E T R + P++++ L +
Sbjct: 1449 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1508
Query: 5353 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQ 5412
++ K + ++E K+ ++ E A + T+ + RA +
Sbjct: 1509 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------- 1556
Query: 5413 HQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 5472
QQ+ + ++A+L+ + ++ T L+ + I D +K L E ++ E
Sbjct: 1557 -QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1615
Query: 5473 EMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5531
E K+ V++ + K NI T ++ + G+ PP SE +
Sbjct: 1616 E---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIST 1661
Query: 5532 RINQLSARWQQVWLLALERQRKLND 5556
+ QLS Q + L + K+ D
Sbjct: 1662 KKEQLSEALQTIQLFLAKHGDKMTD 1686
Score = 51.6 bits (122), Expect = 2e-05
Identities = 138/725 (19%), Positives = 278/725 (38%), Gaps = 93/725 (12%)
Query: 4820 HQATVETVNKAGNELLESS------AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
HQ + + + LE S +G D + L + Q ++ +L+ E RE+Q +S
Sbjct: 1183 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE-REEQEES 1241
Query: 4874 TLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY---SQLKAKE 4930
+ SE+ + L L E +L T E+ D H ++ Q K K+
Sbjct: 1242 VYNL---YISEVRNIRLRLENCEDRLIRQ------IRTPLERDDLHESVFRITEQEKLKK 1292
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE------EA 4984
E +L D + ++ S + SV L + +VV M + S +
Sbjct: 1293 E-LERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT 1351
Query: 4985 LNLATEFQNSLQEFINW--LTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
+NL + + + + L E+ IA N + + I K + +EV+ R
Sbjct: 1352 VNLVLKNTQAAEALVKLYETKLCEEEAVIADK-----NNIENLISTLKQWRSEVDEKRQV 1406
Query: 5043 IIELDQTGNQLKFLSQKQ---------DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
L+ + K +S + D K + RW+ V + R R L+
Sbjct: 1407 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1466
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIK---LQLSKHKEFQKTLGGKQP 5150
K K + + + L DW++ E+ E N P+ K QL++ K + KQ
Sbjct: 1467 GKSLKYYRDTYHPLDDWIQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVSEIEMKQS 1524
Query: 5151 VYDTTIRTGR----ALKEKTL-------LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
D + +K+ L + + QK ++ D + + ++ + +
Sbjct: 1525 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1584
Query: 5200 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 5259
+ Q++ + L + E L E++ H ++ K QK + +
Sbjct: 1585 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH---------VEKAKELQKWVSNIS 1635
Query: 5260 GTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFR 5319
T++ +++G+ + + + + ++LS T+ +L ++K K + R
Sbjct: 1636 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI-QLFLAKHGD-----KMTDEER 1689
Query: 5320 DTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEV 5379
+ + ++ L E+ L +E+L+ L ++ KVEEK V E
Sbjct: 1690 NELEKQVKTLQESYNLL--------FSESLKQLQESQTSGDVKVEEKIV-AERQQEYKEK 1740
Query: 5380 ILAVCHPDCITTIKHWITIIRARF--EEVLTWAKQHQQRLETALSELVANAELLEELLA- 5436
+ +C D +T ++ + + F + K++Q + E ++ +A+ L E++
Sbjct: 1741 LQGIC--DLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKN 1798
Query: 5437 ---WIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI 5493
+++ L Q D+ I Q ++ K + E E ++K ++D+V T ++
Sbjct: 1799 TENFLKENGEKLSQEDKALIEQKLNEAK-IKCEQLNLKAEQSKK--ELDKVVTTAIKEET 1855
Query: 5494 EPTHA 5498
E A
Sbjct: 1856 EKVAA 1860
Score = 40.0 bits (92), Expect = 0.069
Identities = 37/141 (26%), Positives = 63/141 (44%), Gaps = 29/141 (20%)
Query: 5430 LLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME-EMTRKQPDVDRVTKTY 5488
++ L+ WI+ TT+ +R P N +KAL ++ F E E+ K+ + ++ + Y
Sbjct: 457 MVNYLIQWIRHHVTTMSERT---FPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLY 513
Query: 5489 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5548
K I +IE GR L Q P N + W ++ + L
Sbjct: 514 KLLEI------WIEF----GRIKLLQGYHP---------------NDIEKEWGKLIIAML 548
Query: 5549 ERQRKLNDALDRLEELKEFAN 5569
ER++ L ++RLE L++ AN
Sbjct: 549 EREKALRPEVERLEMLQQIAN 569
Score = 39.3 bits (90), Expect = 0.12
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363
K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + +
Sbjct: 768 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 826
Query: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423
EE + A + E+ + T + + +++ ++L ++ ++ L+T L
Sbjct: 827 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 881
Query: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483
V+ A L W+ E + D NI R K H M E+ +K+ ++
Sbjct: 882 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 935
Query: 5484 VTKTYKRKNIE 5494
V + ++ +E
Sbjct: 936 VQEIAEQLLLE 946
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 4237 bits (10988), Expect = 0.0
Identities = 2190/4089 (53%), Positives = 2948/4089 (72%), Gaps = 96/4089 (2%)
Query: 1905 RLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQ 1964
RL + ++E EK +H + + ++L+ WV N + L + + +
Sbjct: 1427 RLEEEEKSLEEEK----KEHVE---KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1479
Query: 1965 QYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQT 2024
+ ++ +K QL IQ F+++H ++ ++ ++ + + LQ S+ + ++
Sbjct: 1480 E-------ISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1532
Query: 2025 AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 2084
Q+ Q +E +V Q++ ++L+ +C + Q E L GHQ D
Sbjct: 1533 LKQLQESQTSGDVKVEEKIVAERQQEYK---EKLQGICDLLTQTENRLIGHQEAFMIGDG 1589
Query: 2085 SA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE 2143
+ L+K QS ++LQ D+Q A + A VVK+ E F++EN KLS + + +KL++AK
Sbjct: 1590 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1649
Query: 2144 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 2203
+ E L + ++KEL++ VT+A+++ETEK A K+L E+K KI+ LLDW+++V +
Sbjct: 1650 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1709
Query: 2204 LLTNLPGMEQLSGASLEKG---------------ALDT-TDGYMGVNQAPEKLDKQCEMM 2247
T + + +G ++G L+T DG +G Q E L++Q + +
Sbjct: 1710 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKV 1767
Query: 2248 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 2307
KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ LQ+ + ELK Y T+LA+SE
Sbjct: 1768 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1827
Query: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV 2367
++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G L + LKRQ SFSEDV
Sbjct: 1828 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1887
Query: 2368 ISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNLVKDKLKDATERYTALHSKCT 2423
ISHKGDLR++TISG +VL+ S + GK + S V+ KL AT+R+ +L+SKC
Sbjct: 1888 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1947
Query: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
LG++L L+ +Y +++++ L A +QACEA K LS+ +A DP LQ QL TK LQ
Sbjct: 1948 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2007
Query: 2484 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2543
+++ QV VEKL+K A +++ G P +Q+T D I+ ++ LS S+ ER+ LQ
Sbjct: 2008 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2067
Query: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603
+ +S SVQ+ L+ +L +G VE +L+ + L+S +Q+ ++ N+ L+QDIA ++SS
Sbjct: 2068 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2127
Query: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663
+ A E V +FMET D +TA+ LQ K+ ++S RF + + +E + +++L + E+FE+
Sbjct: 2128 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2187
Query: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC 2723
LS KLQ F+E K++ L + P +D+T Q +QE E + +++L+ L L+ E+SS
Sbjct: 2188 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH 2247
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G D ++ NL K F E++ T+KE+++ +SCQEQLD F+ LV++ + W+KET
Sbjct: 2248 GLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTK 2307
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD---S 2840
+P + S A++L K +E K L + W+ K ++++N G SL NLI +T P +
Sbjct: 2308 KVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA 2367
Query: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900
K+G + + + + + K LT I+ DM+D++ YE LG +L ++ L L+
Sbjct: 2368 AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS 2427
Query: 2901 RMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQ 2960
++++ +E+++++QWL+ + +PT TE VK Q E NK+F AEL+QN K+Q
Sbjct: 2428 KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2487
Query: 2961 KVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020
++K+ L LL P++ EA WK++ E++S+W+ ++T+ RQ++LEES+++L FQ
Sbjct: 2488 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2547
Query: 3021 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080
E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+EF R+ Q+EQL A QGIL
Sbjct: 2548 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2607
Query: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140
+ PG+ V+++L ++ QKW LT +L+ R IDQAIVKSTQYQ LL+ LS+K+
Sbjct: 2608 SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2667
Query: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
+ +LS A+ST P+A+ QQLE +++ +++Q ++K AQ LC++LS L+ E+YLK
Sbjct: 2668 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2727
Query: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
EL ++LE + + +E A + + LQ+A AS+ QFQQM + + WLD K+ +Q K+
Sbjct: 2728 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2787
Query: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
PISAKL+ L+S ++++++F K+L S YE +AEGE+LLL G EK LQ QL +
Sbjct: 2788 PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ-GSEKAALQLQLNTI 2846
Query: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380
K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+ C+ + E++ LDP + E+
Sbjct: 2847 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 2906
Query: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440
S+ + K++ E+++ ++E+LN+ A+ L++ E D++ + DE + Q +D VTE+L +
Sbjct: 2907 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2966
Query: 3441 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 3500
K LE MTQ+ +EFQE K +++++ AK QL+I D+LGSQA SNK L L+ QQ+ LQ
Sbjct: 2967 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3026
Query: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560
AL+ QVD + Q LV +A D S +L Q E QE + Q+V+ C +E KL+G
Sbjct: 3027 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3086
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
IG F +REMFSQ A+ DDELD M +GRD ++LQ Q E ++ FL K+ L + +
Sbjct: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN 3146
Query: 3621 AECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679
C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR+EQ+E T+ R+E+FY KLK
Sbjct: 3147 KTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE 3206
Query: 3680 LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3739
+ AEE E Q VG E E INQQL FK+FQKE+++PLQ K Q VN LGQGLIQS
Sbjct: 3207 FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQS 3266
Query: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
A K QGLEHD++++NARW TLNKKVAQR AQLQEALLHCG+FQDALE LLSW+ DTE
Sbjct: 3267 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3326
Query: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
EL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV++++ EG +IA +AE AD+ KI
Sbjct: 3327 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3386
Query: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919
QL L+SRW LL+KA R +QLE I V+A+QFHET EP++++L+ EK+L N EP+GT
Sbjct: 3387 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT 3446
Query: 3920 QTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979
Q +K+++QI +HKALE+DI NH +HQAV IGQSL L+S ++ ++ K+D Q Y
Sbjct: 3447 QASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI 3506
Query: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DKLS + V+D+ + L +Q ++
Sbjct: 3507 EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE 3566
Query: 4040 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR 4099
L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+KL+ IK RY DIT S+ +
Sbjct: 3567 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
Query: 4100 TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEH 4159
TLEQA QLA + ST+EEL WL +VE EL + Q GE+ Q Q R KELKKE +
Sbjct: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3686
Query: 4160 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
+ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ
Sbjct: 3687 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3746
Query: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK F+++I+RHKD +D+L
Sbjct: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
+I C EE+K +++K + +++ Y+ I +NSERY +LERAQ LVNQFWETYEEL PW
Sbjct: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 4399
+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKPHIDK+ K GPQL EL+P EG
Sbjct: 3867 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3926
Query: 4400 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLR 4459
++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ FHDKI+ +LE+LE + RLR
Sbjct: 3927 FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ---FHDKIDQILESLERIVERLR 3983
Query: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4519
PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RGEE+I RS G DKD++AK +Q
Sbjct: 3984 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
Query: 4520 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI 4579
DKLDQMVF WE+I EERE K LDV+ELAEKFW D +L+ TIKDTQD + DLE PGI
Sbjct: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
Query: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639
DPS++KQQ EAAETI+EE DGL EEL+ + LG++LI ACGE +KP V+KSIDE+N+AW+
Sbjct: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
Query: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699
+LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D KL +M P+GTDL TVK Q+ E
Sbjct: 4164 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4223
Query: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++PL ELK +W++L E+I +RQ
Sbjct: 4224 LKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQ 4283
Query: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
HKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GDPK IE+ELAKHHVL+NDVLA
Sbjct: 4284 HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLA 4343
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
HQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++VL+KTE+R+QQL L+QA+
Sbjct: 4344 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4403
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
GFH EIED LT E L ASKP GGLPETA+EQL+ HME+ + +AKEETY L+ K
Sbjct: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4463
Query: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFI 4999
G+ M L+R + + +Q + L++KW V +K+ ERK+KLEEALNLA EF NSLQ+FI
Sbjct: 4464 GQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
Query: 5000 NWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQK 5059
NWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+HR+QIIELD+TG LK+ SQK
Sbjct: 4523 NWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQK 4582
Query: 5060 QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD 5119
QDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQFHEAW KL++WLE++E LD
Sbjct: 4583 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4642
Query: 5120 SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179
SELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTGR+LKEKT L +D+ KLD+ L
Sbjct: 4643 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDML 4702
Query: 5180 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 5239
E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+DWLY+VEPQLAEDQPVHGD+D
Sbjct: 4703 SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID 4762
Query: 5240 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 5299
LVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD++WVK Q+QELSTRW+TVC
Sbjct: 4763 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4822
Query: 5300 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 5359
LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF G LPDD +AL++LID HKEF
Sbjct: 4823 LSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF 4882
Query: 5360 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
MKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITIIRARFEEVL WAKQHQQRL +
Sbjct: 4883 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4942
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+ VKALIAEHQTFMEEMTRKQP
Sbjct: 4943 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5002
Query: 5480 DVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQ 5535
DVD+VTKTYKR+ +P +H P ++K R+ GRK + P +Q E KNPR+N
Sbjct: 5003 DVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPASSLYPSGSQTQIETKNPRVNL 5061
Query: 5536 LSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFR 5595
L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+WRKKYMRWMNHKKSRVMDFFR
Sbjct: 5062 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5121
Query: 5596 RIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD 5655
RIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 5122 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5181
Query: 5656 AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRS 5715
AY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 5182 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5241
Query: 5716 TVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPS 5775
TVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL +GASQGM FR RGRRS+PS
Sbjct: 5242 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5301
Query: 5776 SRAASPTRSSSSASQSNHSCTSMPSSPAT------------------------------- 5804
SR ASP RS+S +SQ+ + + P PAT
Sbjct: 5302 SRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAE 5359
Query: 5805 ----PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSAS 5860
P + P GSKL+ P + S + +G+ S + A+ +T AD KK+ S
Sbjct: 5360 CSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPS 5417
Query: 5861 RPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS---ESSAAGGQGNSRRGLNKPS 5917
RPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD ++ + SR KPS
Sbjct: 5418 RPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPS 5477
Query: 5918 KIPTMSKKT 5926
KIPT +K+
Sbjct: 5478 KIPTPQRKS 5486
Score = 716 bits (1847), Expect = 0.0
Identities = 792/3865 (20%), Positives = 1615/3865 (41%), Gaps = 324/3865 (8%)
Query: 1812 SYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIIS 1871
+Y+ L+ + + K Q E + + LC+ + + + ++ L+S + +++
Sbjct: 1166 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV--- 1222
Query: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV---LNQHTQLE 1928
+ Q+ ALE + + + + T+ R L F E V N H Q++
Sbjct: 1223 ---DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1279
Query: 1929 GRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQ 1988
RL+DL + + L+ Y D P+ + Q++ IQ
Sbjct: 1280 NRLRDL----------------------EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1317
Query: 1989 FFISEHAQDLSPQQNRQ-MLRLLNELQRSFQDILEQTAAQVDAL--QGHLQQMEQEALV- 2044
E+++ L+ Q N+Q ML E+++S D ++ A Q A LQ M A+V
Sbjct: 1318 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1377
Query: 2045 ---------KTLQKQQNTCHQQLEDLCSWVGQAERAL------AGHQGRTTQQDLSALQK 2089
+ +Q + Q+ DL + + AG + +++ +L++
Sbjct: 1378 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1437
Query: 2090 NQSDLKDLQDDIQNRATSFATVVKDIE--GFMEENQTKLSPRELTALREKLHQA------ 2141
+ + + ++Q ++ + +KD E G ++ K+S E++ +E+L +A
Sbjct: 1438 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1497
Query: 2142 -----------------KEQYEALQEETRV----AQKELEEAVTSALQQETEKSKAAKEL 2180
++Q + LQE + + K+L+E+ TS + E+ A+
Sbjct: 1498 FLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKIVAERQ 1556
Query: 2181 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 2240
E K+K+ + D +T Q L G ++ A DG + + + K
Sbjct: 1557 QEYKEKLQGICDLLT-------QTENRLIGHQE---------AFMIGDGTVELKKYQSKQ 1600
Query: 2241 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK---EQ 2297
++ + M+ Q L +N + FL ++G L+ E++ +++QKL E K EQ
Sbjct: 1601 EELQKDMQGSAQALAEVVKN-------TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQ 1653
Query: 2298 YSTSLAQSEAELKQVQT--LQDELQKF-----LQDHK----EFESWLERSEKELE---NM 2343
+ QS+ EL +V T +++E +K L++ K WL +K+ E
Sbjct: 1654 LNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTK 1713
Query: 2344 HKG-------------------------------------GSSPETLPSLLKRQGSFSED 2366
HK G++ E L ++ + E
Sbjct: 1714 HKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEK 1773
Query: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
+IS + T S Q +L+ + + +E ++ +K+ LK E A K +L
Sbjct: 1774 IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE-LKVHYETALAESEKKMKL- 1831
Query: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
+ L + +F + W+Q E +E L + A D L +L K E++
Sbjct: 1832 --THSLQEELEKFDADYTEFEHWLQQSEQELENL--EAGADDINGLMTKLKRQKSFSEDV 1887
Query: 2487 AEHQ-------VPVEKLQKVARDIMEIEG---EPAPDHRHVQETTDSILSHFQSLSYSLA 2536
H+ + ++ + A+ + +G + + HR VQ D F+SL
Sbjct: 1888 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1947
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS---SLSSGVIQEALATNMKL 2593
+ L+ + + Q +++ LL + E K +S ++ +Q L L
Sbjct: 1948 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT-ASKHLSEPIAVDPKNLQRQLEETKAL 2006
Query: 2594 KQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSL 2651
+ I+ Q+ ++E ++ ++ S A +Q L ++ R+E L E+ L
Sbjct: 2007 QGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 2066
Query: 2652 KKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED----QQ 2707
+ L ++ + ++ +M N L Q + T Q I N+ +E +Q
Sbjct: 2067 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNST-ALQDIISKNIMLEQDIAGRQ 2125
Query: 2708 ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEF 2767
+++ + V + Q ++++L F+E KE + +++ F
Sbjct: 2126 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2185
Query: 2768 RKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS 2827
L Q +L+ ++ TE + K++ + ++++ ++ +E
Sbjct: 2186 ENLSEKLQTFLETKTQAL--TEVDVPGKDVTELSQYMQESTSEFLEHKKHLE-------V 2236
Query: 2828 LENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGV 2887
L +L+ EI+ S G LPS D + ++++ K++++
Sbjct: 2237 LHSLLKEIS---SHG-----LPS---------------DKALVLEKTNNLSKKFKEMEDT 2273
Query: 2888 LHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKA 2947
+ E++E++ + +++ S+ W+ +E K + + E + E K
Sbjct: 2274 IKEKKEAVTSCQEQLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKK 2330
Query: 2948 FLAELEQNSPKIQKVKE---ALAGLL--VTYPNSQEA-------------------ENW- 2982
+ +P+IQKV +L L+ VT P A E W
Sbjct: 2331 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2390
Query: 2983 -------KKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL--MEKEL 3033
KK +++ +E + + +L S L Q S + WL M K
Sbjct: 2391 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2450
Query: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQV 3093
P D + Q +Q K FEA +Q+ + + LT + + T +
Sbjct: 2451 TKWQQTPAPTDTEAVKTQVEQ----NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2506
Query: 3094 ---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 3150
++ L I+ KW EL R +++++ TQ+Q + L + + +SV
Sbjct: 2507 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2566
Query: 3151 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQ-YLKDELKKRLET 3209
+S P + Q ++ + + + ++ + GE L+ +K++L
Sbjct: 2567 PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2626
Query: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
V L +DR + + A+ + Q+Q + L L D ++ + + +S + +
Sbjct: 2627 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2686
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
QL+ ++ ++ + Q +V A E L V K L QL + ++++ +
Sbjct: 2687 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2746
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAML 3389
K + L+ + ++Q D W++ K + ++ + + SL++
Sbjct: 2747 KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDF 2806
Query: 3390 NEVEKRRSLL--EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEE 3447
++ +S + + + ++L+ + +++ ++ + I N D ++++ + L+E
Sbjct: 2807 SKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2866
Query: 3448 MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVD 3507
++ +++E + + ++ ++ LE A ++ KL++ Q+ + V+
Sbjct: 2867 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 2926
Query: 3508 YLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR 3567
L N L+ D + + + Q+ V ++++S +EN + +F
Sbjct: 2927 LLNNTANSLLSVCE--IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEV 2984
Query: 3568 VREMFSQLADLDDELDGMGAIGRDTDS------LQSQIEDVRLFLNKIHVLK-----LDI 3616
+E QL ++LD ++G S LQ+Q + ++ +++ + K L +
Sbjct: 2985 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVV 3044
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK 3676
EAS++ +GT D+L ++E + ++ L+++ + LE L + F
Sbjct: 3045 EASDS--------KGTSDVL---LQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNT 3093
Query: 3677 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
++ + ++ VG + E + +Q K F K +++ L N + +
Sbjct: 3094 IREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK-KLEALMASNDNANKTCKMM 3152
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796
+ + D+ G++ D+E ++ + N L + R Q++ + +F L+ L
Sbjct: 3153 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQ 3212
Query: 3797 DTEELIANQKPPSAEYKVVKAQIQEQKLLQR----LLDDRKATVDMLQAEGGRIAQSAEL 3852
EE +Q P E + + Q+ K+ Q+ L ++ V+ L G I +A+
Sbjct: 3213 KAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ--GLIQSAAKS 3270
Query: 3853 ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLA 3912
+ + L+ + +RW L K A R QL++ L+ +F + E + ++ TE+ +A
Sbjct: 3271 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3330
Query: 3913 NSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID 3972
N +P + ++ QI K L+ +++ + V + G+ +++ PA++ + +++
Sbjct: 3331 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3390
Query: 3973 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV 4032
L +R+ + ++ + L+ A+ F E + WL +E +L + +
Sbjct: 3391 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3450
Query: 4033 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 4092
L Q A H AL ++I+N K++ QA+ GQ+L ++ E+ ++Q KLD + Y +I
Sbjct: 3451 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3510
Query: 4093 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKEL 4152
S L+QA A F EL WL EV ++L+ Q + E + + Q + L
Sbjct: 3511 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3570
Query: 4153 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGL----DKLVSDANEQYKLVSDTIGQRVD 4208
+++++ L V++ LEL+ + + DKL + +YK ++
Sbjct: 3571 QEDIL---LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA-IKARYKDITKLSTDVAK 3626
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
++ A+Q +++ + W+ + + +L++ L+ ++ + K + +
Sbjct: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3686
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
K +D L S + + L++ ++Y +S +++ ++ A + Q
Sbjct: 3687 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3746
Query: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 4388
F + + WI ET + L ++ +Q Q + + I HK ID L+K G
Sbjct: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
Query: 4389 PQ-LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ + + EE + +++K K Y I + +R L L+ A S Q E ++++ P
Sbjct: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
L +++ S+L P L E + +R+ +++ + + +P + + + G +L+ S
Sbjct: 3867 LTETQSIISQLPAPAL---EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP 3923
Query: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567
G IQ+K + IK ++R + + + + +F + +L +++
Sbjct: 3924 G-----EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978
Query: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK--- 4624
+ + S + IK+Q+ + + + + L E ++ G ++I G T+K
Sbjct: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038
Query: 4625 -PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683
V+ +D+M WEN++ +ER KL D M+ A ++ ++ + +T + +
Sbjct: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4098
Query: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
G D + VK Q + + E+ Q E++ + + G ++ A E D+ I+++ + E
Sbjct: 4099 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI-AACGEPDKPIVKKSIDE 4157
Query: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
L W++L + R KLE A+ A Q+Q L+ + W+ L + PI D + +
Sbjct: 4158 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4217
Query: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLES-SAGDDASSLRSRLEAMNQCWESVLQ 4862
+ ++ + K++ Q +E +N LL+ + D +++ L + W+S+ +
Sbjct: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4277
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4922
+ R+ +L+ L F +++ L LT E LS KP GG P+ +L H L
Sbjct: 4278 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4337
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
+ + A + T + ++K L+ S + + +L Q+W V K E+RK +L+
Sbjct: 4338 QNDVLAHQSTV-EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4396
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
AL A F +++ WLT E+ L + P + T Q+ H A +
Sbjct: 4397 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4456
Query: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
L Q G Q+ K I + +++ +WE V + ER L++A A +FH
Sbjct: 4457 YKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4516
Query: 5103 AWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL 5162
+ + I+WL AE L+ S D + Q+ +HK F + + +TG L
Sbjct: 4517 SLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL 4576
Query: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
K + +D + N L V+ +W+ V + VER L++A + QF +A L++WL
Sbjct: 4577 KYFS-QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS--RDDT 5280
+ E L + + D D + + HK FQK LG + R+GR L E + DD
Sbjct: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4695
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
+ L EL +WDT+C SV +Q++LE+AL + F D + L++WL E L
Sbjct: 4696 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4755
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
+ D + + +LID HK F K++ ++ V + ++ D + +K + +
Sbjct: 4756 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKVQMQELS 4814
Query: 5401 ARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRV 5460
R+E V + Q RLE AL + ++ LL W+ AE TL R +P + D +
Sbjct: 4815 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTL--RFHGVLPDDEDAL 4872
Query: 5461 KALIAEHQTFMEEMTRKQPDVDRVT 5485
+ LI +H+ FM+++ K+ ++++ T
Sbjct: 4873 RTLIDQHKEFMKKLEEKRAELNKAT 4897
Score = 442 bits (1137), Expect = e-123
Identities = 584/3078 (18%), Positives = 1246/3078 (40%), Gaps = 292/3078 (9%)
Query: 1795 QNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDL 1854
Q TR L ++ + L L + N+E K+ + LN LQD++ + +LE+++
Sbjct: 2067 QITLTRSLSVQ--DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2124
Query: 1855 TTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914
+ ++ E V + + + +L+ K+L S S L +
Sbjct: 2125 QSSINAMNEKVKKFM----ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL-- 2178
Query: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC-LQQY-EDLKQP 1972
KTKV E + L+ ++ K L +E+DV ++ L QY ++
Sbjct: 2179 --KTKV----ELFENLSEKLQTFLETKTQAL------TEVDVPGKDVTELSQYMQESTSE 2226
Query: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032
E K L+ L + E + P +L N L + F++ +E T
Sbjct: 2227 FLEHKKHLEVL----HSLLKEISSHGLPSDKALVLEKTNNLSKKFKE-MEDTI------- 2274
Query: 2033 GHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQS 2092
E++ V + Q+Q + ++ L SW+ + + + Q +DL K+
Sbjct: 2275 -----KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLE 2326
Query: 2093 DLKDLQD----------DIQNRATSFATVVKDI-------------------EGFMEENQ 2123
D K LQ+ + N S ++ + EG +
Sbjct: 2327 DTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2386
Query: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183
+ + LT++++ + YE L + EL + S LQ+ E+S
Sbjct: 2387 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL-SKLQKAQEES--------- 2436
Query: 2184 KKKIDALLDWVTSVGSSGGQ-LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 2242
A++ W+ + + + T P + +E+ + VN+ E DK
Sbjct: 2437 ----SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492
Query: 2243 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ------QKLGELKE 2296
E+++ T A P +QML Q+L +L
Sbjct: 2493 LTELLEENPD------------TPEA------------PRWKQMLTEIDSKWQELNQLTI 2528
Query: 2297 QYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSL 2356
L +S L Q QT++ +L++ WL E + + P L +
Sbjct: 2529 DRQQKLEESSNNLTQFQTVEAQLKQ----------WLVEKELMVSVLGPLSIDPNMLNTQ 2578
Query: 2357 LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYT 2416
++ ++ + K +T +GQ +L + G++PS + +VK++L T+++
Sbjct: 2579 RQQVQILLQEFATRKPQYEQLTAAGQGILS-----RPGEDPS-LRGIVKEQLAAVTQKWD 2632
Query: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
+L + + ++ + + Q+Q+ SL + + + L+ V++ P + +QL
Sbjct: 2633 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA--VSTHPDAMNQQL 2690
Query: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
T +++++E+ + + ++ Q + D+ + E + + IL F+ +
Sbjct: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYL-KAELSRQLEGILKSFKDVEQKAE 2749
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
LQ A A S Q+ + ++ S V++ + + +
Sbjct: 2750 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2809
Query: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
+ Q E T + + A LQ +L + ++ Q +E+E+ LK+ L
Sbjct: 2810 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2869
Query: 2657 QA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2712
+A E E L + + N + + + + + +++ L EM+ ++
Sbjct: 2870 KALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE--NSIAKLKSLQKEMDQHFGMVEL 2927
Query: 2713 LEHLVTE-LSSCGFALDLCQHQDR-------------------VQNLRKDFTELQKTVKE 2752
L + LS C ++ +++ ++N+ + F E Q+ KE
Sbjct: 2928 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2987
Query: 2753 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812
++ +EQLD L Q + + + + S+ A L+ Q++ K L D
Sbjct: 2988 SKRQLQCAKEQLDIHDSL--GSQAYSNKYLTMLQTQQKSLQA--LKHQVDLAKRLAQDLV 3043
Query: 2813 -----SKG----------------TLVEEINCKGTSLE----------NLIMEITAP--- 2838
SKG TL ++++ K + LE N I E+ +
Sbjct: 3044 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 3103
Query: 2839 -----DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2893
DS G ++ ++ + K L + + N K K+ E
Sbjct: 3104 FDDELDSMAPVGRDAETLQKQKETIKAF--LKKLEALMASNDNAN-KTCKMMLATEETSP 3160
Query: 2894 SLQAILNRMEEVHKEANSVLQWLESKEE----VLKSMDAMSSPTK--------------- 2934
L I +E + K+ N +L +++EE +K ++ S K
Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3220
Query: 2935 -------TETVKAQAESNKAF-LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ 2986
TET+ Q K F E+E K Q V GL+ + S + +
Sbjct: 3221 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 3280
Query: 2987 EELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPN 3046
+++N+RW+ + R QL+E+ H FQ A L W+++ E ++ P S +
Sbjct: 3281 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3340
Query: 3047 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT--GPGDVSLSTSQVQKELQSINQKW 3104
++ AQ Q+ + + + + R+ E + + I T P D ++ K+L ++ +W
Sbjct: 3341 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD----KVKILKQLSLLDSRW 3396
Query: 3105 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 3164
L +K +R+ Q++ V + Q+ E L+ L+E + + +RL I TQ +++Q+
Sbjct: 3397 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3456
Query: 3165 ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADR 3224
+ + D+ + + +A ++ L VL + KD ++ +L+ + +++ + R
Sbjct: 3457 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED-KDMVQSKLDFSQVWYIEIQEKSHSR 3515
Query: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 3284
LQ AL + + F + EL WL++ + +K E L Q E Q+ +
Sbjct: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3575
Query: 3285 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 3344
+ + + G LL G+E +Q++L +K +++++K + D L+ +Q
Sbjct: 3576 LRKQNVDQALLNGLELLKQT-TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3634
Query: 3345 AQKYQWHVEDLVPWIEDCKAKMSELRV-TLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 3403
A++ E+L W++ + ++ L + + +R K + E + ++LL+ LN
Sbjct: 3635 ARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3694
Query: 3404 SAADILINSSE-ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREF-QESFKN 3461
+ L+ +G+ A N+ V++ + K ++ R ++F Q +
Sbjct: 3695 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3754
Query: 3462 IEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA-QQEVLQALEPQVDYLRNFTQGLVEDA 3520
+ E K + + D Q ++ L+ + E+L+ + D +++ + + A
Sbjct: 3755 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK--IMTA 3812
Query: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
+ + + + + + + Q + + +E + QF E++ L +
Sbjct: 3813 CSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQS 3872
Query: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE---EEGTLDLLG 3637
+ + A + ++L+ Q E+ R I K I+ +LE EG
Sbjct: 3873 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG----FS 3928
Query: 3638 LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV 3697
++ + A + ++ E K R L+ + + F+ K+ + ++ E +
Sbjct: 3929 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 3988
Query: 3698 GTEVEIINQQLADFK--MFQKEQVDPLQMKLQQVNGLGQGLIQSAG---KDCDVQGLEHD 3752
EVE I +Q+++ K E++ PL L+Q G+ +I +G KD + ++
Sbjct: 3989 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQDK 4045
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812
++++ W ++ V +R A+L + + KF L+ + DT++ I + + P +
Sbjct: 4046 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4105
Query: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872
VVK Q + + ++ +D + +D++ G + + D+ + ++ L S W L
Sbjct: 4106 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4165
Query: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI---- 3928
R +LE+ + A Q+ + + + D++ + KLA+ P+GT ++QQI
Sbjct: 4166 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4225
Query: 3929 -IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+ +A ++ IE + HQA + L +T +++ + + + L+ + +++R
Sbjct: 4226 QFKSEAYQQQIEMERLN-HQAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
+ L+ AL F E+L WL E LS + + A H L ++
Sbjct: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107
+ + V+ K G L++ + GEE +Q KL+ + R+ ++ + + + L+ A +
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401
Query: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM----EHRLVL 4163
A F E+L WL + E L S P G +P+ + Q + EV
Sbjct: 4402 AKGFHGEIEDLQQWLTDTERHLLAS---KPLG-GLPETAKEQLNVHMEVCAAFEAKEETY 4457
Query: 4164 DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 4223
++ + + +L P A +D+ +++ E+++ V + +R +++ A+ + ++ +
Sbjct: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
Query: 4224 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF 4283
+ W+ + ++ L L D Q+ K F+ ++ H++ + EL + +
Sbjct: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
Query: 4284 GTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEET 4343
++ +++ S+ ++E + ER L+ A+ QF E + +L W+EE+
Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
Query: 4344 RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN--PEEGEM 4401
+ A D ++++ Q + ++ ++S+ D + G LKE ++
Sbjct: 4638 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697
Query: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
+++ + + + I + +R L+EA+ S Q T D ++ +++ L + +L
Sbjct: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT---DALQALIDWLYRVEPQLAED 4754
Query: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521
+ ++D + I ++K+ EL K S +ALKR ELI +G+ D + ++Q
Sbjct: 4755 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQ-- 4809
Query: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4581
+ ++ WE + A + ++ + L AE+F + ALL + + + + D
Sbjct: 4810 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 4869
Query: 4582 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4641
++ ++ + ++ + EL +G ++ C ++ I + +E +
Sbjct: 4870 DALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4929
Query: 4642 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD--NTVIKLCTMPPVGTDLNTVKDQLNE 4699
K+ ++L A+ + Q+ L+A+ WL T + + ++ VK + E
Sbjct: 4930 LAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 4989
Query: 4700 MKEFKVEVYQQQIEMEKL 4717
+ F E+ ++Q +++K+
Sbjct: 4990 HQTFMEEMTRKQPDVDKV 5007
Score = 404 bits (1039), Expect = e-111
Identities = 676/3612 (18%), Positives = 1415/3612 (39%), Gaps = 437/3612 (12%)
Query: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
++ L+K+ QN +++ +DL +WV + + L RT SDL
Sbjct: 585 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 631
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149
++ ++N + +++ E ++E K+S ++TA EKLH+ + QY L
Sbjct: 632 PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 688
Query: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201
+R ++ L+ V+ A + E E+ + A + +E I D+ +
Sbjct: 689 NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 748
Query: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258
Q N+ +++++ L + A T + Y Q Q C+ ++ +E +
Sbjct: 749 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 808
Query: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317
+ F N E L+ ++ +YS + S +L+ VQ +
Sbjct: 809 EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 852
Query: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368
E ++ LQ + + +++ ++ + P +K + + I
Sbjct: 853 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 912
Query: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421
SH+ + ++ +G + + F KE ++ N ++ + ++ T H
Sbjct: 913 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 968
Query: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480
SH+NM + +H N D ++A + A+++ +L PG Q+ L+ +
Sbjct: 969 -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 1013
Query: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540
E+ E + DI ++E E ++ QE S AER
Sbjct: 1014 SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 1059
Query: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593
Q +SV S +++I +N E + + + + + ++ L ++ KL
Sbjct: 1060 -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1112
Query: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649
K+++ R K L T + F + A S++ L+ +L V Q Q+ +K
Sbjct: 1113 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 1172
Query: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709
++ +L + E L + + + ++A N +I + +++ E++++++
Sbjct: 1173 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 1228
Query: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
LE + + + LD H+++ L + + + + R +D
Sbjct: 1229 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1288
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
+ L +R W+++ E + K E Q E+ K+L + LV E
Sbjct: 1289 GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1340
Query: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874
I K + ++ T D + +T + V S S V I +
Sbjct: 1341 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1400
Query: 2875 SDVNLKYEKL-----------GGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2923
D+ +Y L G L +E +++ +E ++A + +W+ + + L
Sbjct: 1401 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1460
Query: 2924 KSMDAMSSP-------------TKTETVKAQAESNKAFLAEL--EQNSPKIQKVKEALAG 2968
K + P TK E + ++ + FLA+ + + ++++ +
Sbjct: 1461 KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1520
Query: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ------------LEESASHLAC 3016
L +Y N +E+ K++QE S + E VA ++Q L ++ + L
Sbjct: 1521 LQESY-NLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIG 1579
Query: 3017 FQAA-----------ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEAR 3065
Q A + Q + ++K++ + N N K+ + + +E +A
Sbjct: 1580 HQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1639
Query: 3066 RQQH--------EQLNEAAQ-------GILTGPGDVSLSTSQVQKELQSINQK------W 3104
+Q EQLN A+ ++T K+L+ K W
Sbjct: 1640 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699
Query: 3105 VELTDKLNSRSSQIDQAIVK--STQYQE--LLQDLSEKVRAVGQRL--SVQSAISTQPEA 3158
+ DK + R+ + +++ T +QE + E+ G L V + T E
Sbjct: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759
Query: 3159 VKQQLEET----SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 3214
+ QQ ++ +I S + + + AQ L ++ QYL E K++L+ L
Sbjct: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQG-----QYLSPEEKEKLQKNMKEL 1814
Query: 3215 QGLEDLAADRINRLQAALASTQQFQQMFD----ELRTWLDDKQSQQAKNCPISA-KLERL 3269
+ + A + S Q+ + FD E WL + Q+ +N A + L
Sbjct: 1815 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE-QELENLEAGADDINGL 1873
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS-----------VPPGEEKRTLQNQLV 3318
++L+ + F + + H G I G +L + V R +Q +L
Sbjct: 1874 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1933
Query: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE---LRVTLDP 3375
+ + L K + LKD + K Q Y+ L+ ++ C+A S+ + +DP
Sbjct: 1934 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 1993
Query: 3376 VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI----------NSSEADEDGIRDEKA 3425
L+ L +KA+ ++ ++ +E L A++L+ N + D I
Sbjct: 1994 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 2053
Query: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALGSQAC 3484
++++++ E+LQ + L E + N+E + K Q ++ ++ Q
Sbjct: 2054 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL---KEQGQVPLNSTALQDI 2110
Query: 3485 SNKNL---EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL 3541
+KN+ + + +Q + A+ +V T D S AS L + + F
Sbjct: 2111 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETT--------DPSTASSLQAKMKDLSARFS 2162
Query: 3542 EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIED 3601
E + ME + E+F L ++ LQ+ +E
Sbjct: 2163 EASHKHKETLAKMEELKTKV--------ELFENL----------------SEKLQTFLET 2198
Query: 3602 VRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQE 3661
L ++ D+ + +E T + L K+ LE L+ +++ G +
Sbjct: 2199 KTQALTEV-----DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 2253
Query: 3662 QLELTLGRVEDFYRKLKGLND--------ATTAAEEAEALQ--------WVVGTE----- 3700
L L + + +K K + D T+ E+ +A Q W+ T
Sbjct: 2254 --ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI 2311
Query: 3701 ------VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL----------------IQ 3738
E + + L D K Q E+ ++Q+VN G L ++
Sbjct: 2312 VQPSFGAEDLGKSLEDTKKLQ-EKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVK 2370
Query: 3739 SAGKDCDVQG----------------LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
S G + +G ++ DM +I+ + L + +IA+L L
Sbjct: 2371 SGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQ 2430
Query: 3783 KFQDALEPLLSWLADTEELIA--NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
K Q+ ++ WL + Q P + + VK Q+++ K + L V L+
Sbjct: 2431 KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2490
Query: 3841 AE-GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3899
+ + ++ + + + L ++S+W EL RQ++LE+ QF
Sbjct: 2491 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2550
Query: 3900 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL- 3958
+ +L E ++ P+ + Q + + L ++ Q GQ + S
Sbjct: 2551 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRP 2610
Query: 3959 -TSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
P+ +G++ E++ ++ ++ + + + +DQA+ + + + + L++++
Sbjct: 2611 GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLD 2670
Query: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTTGEEVL 4074
+KLSS D +++Q + +EI KK IK QAL L EE L
Sbjct: 2671 NKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQ----IKVAQALCEDLSALVKEEYL 2726
Query: 4075 L--IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+ +L+GI + D+ + ++ L+ A + +FQ + WL +EE S
Sbjct: 2727 KAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKS 2786
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA 4192
S + + + K+ K + + + LL + L ++
Sbjct: 2787 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTI 2846
Query: 4193 NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL----MALGPIRLEQ 4248
+ + + +R +++ +++++ +Y++ + W+ + + L L P E
Sbjct: 2847 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP--AEG 2904
Query: 4249 DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 4308
+ + A+L K+ ++ +H ++ L + + + C E K V+ ++ +SLIQ+ + +
Sbjct: 2905 ENSIAKL---KSLQKEMDQHFGMVELLNNTANSLLSVC-EIDKEVVTDENKSLIQKVDMV 2960
Query: 4309 S-LLNSERYARLERAQVLVNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQ 4364
+ L+S+++ LE +F E +E ++ E + L S A ++ L Q
Sbjct: 2961 TEQLHSKKFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3019
Query: 4365 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
+ + L+ +H+ + K L ++ + + V + + ++ + ++V ++
Sbjct: 3020 TQQKSLQ--ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3077
Query: 4425 LALDEAVS-----QST------QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 4473
L+ + Q+T Q EF D+++ M + + + I A + K+
Sbjct: 3078 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3137
Query: 4474 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4533
++ N +A K A + +L+G + D + +K+ LD
Sbjct: 3138 LMASNDNA----NKTCKMMLATEETSPDLVGIKR--DLEALSKQCNKLLD---------- 3181
Query: 4534 ARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET 4593
RA+ RE + ++ E+F+ + ++ ++ G++ I QQ+ +
Sbjct: 3182 -RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 3240
Query: 4594 I-KEETDGLHEELEFIRILGADLI-FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4651
KEE + L + + + LG LI A T + +D++N W+ LNK +R +
Sbjct: 3241 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 3300
Query: 4652 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4711
L++A+ ++QD L+++ W+ +T + P + VK Q+ E K + + ++
Sbjct: 3301 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRK 3360
Query: 4712 IEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771
+E + +GE + A + D+ I + L+ L WE L K R +LEG + Q
Sbjct: 3361 STVEVIKREGEKIATTA-EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3419
Query: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
F LE L WLT E+ L PI +E ++A+H L++D++ H + G
Sbjct: 3420 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3479
Query: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L S+ +D ++S+L+ + + +K+ R + LQ L A+ F + + +
Sbjct: 3480 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 3539
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + +LS E +Q L + +++ +Q L G L LL +
Sbjct: 3540 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNG-LELLKQTTGD 3598
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
+ + ++ ++ ++ + LE+AL LA ++ +E WL E L +
Sbjct: 3599 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL-L 3657
Query: 5012 ASPPSLILNTVLSQIE-EHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLV 5070
+ ++ SQ + K E ++ + L++ + L L + ++ ++
Sbjct: 3658 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVA 3717
Query: 5071 SVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
R+ V ++ +D A R++QF +A + W+ + E L S +I + D+
Sbjct: 3718 EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3777
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
QL K F + + + D +++G + E+ Q + L +V +DT+C
Sbjct: 3778 TSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM-TACSEEEKQSMKKKLDKVLKNYDTIC 3836
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
+ ER +LE A QF + + L WL + + +++ + + + + H+
Sbjct: 3837 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQ 3896
Query: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
++ + + + + ++G +L+E S + ++ + T + + + + L++
Sbjct: 3897 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 3956
Query: 5311 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
A+ Q+ F D + +LE L + LR ++ + E ++ I +K +E+ +
Sbjct: 3957 AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLY 4016
Query: 5371 NSAVAMGEVILA 5382
+ GE ++A
Sbjct: 4017 ETLKQRGEEMIA 4028
Score = 381 bits (978), Expect = e-104
Identities = 610/3185 (19%), Positives = 1269/3185 (39%), Gaps = 392/3185 (12%)
Query: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
+SSLL + + + + + ++ LL + E++ L+ + S D+
Sbjct: 590 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 631
Query: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2653
+S LE + V R +E +S+ + + K++E+ Q L L EK ES K
Sbjct: 632 PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 686
Query: 2654 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2701
LL + E L F+ + L N+ +++ + + N+
Sbjct: 687 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 746
Query: 2702 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2735
E++ ++EN+ +++ + +L + + L LCQ ++
Sbjct: 747 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 806
Query: 2736 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792
N K+ T+ + +K+ + SC ++ KL Q+ ++E E + T
Sbjct: 807 YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 865
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2848
+ K I LK D K ++ + C +E I + + A +S ++
Sbjct: 866 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 925
Query: 2849 PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2908
G+ + T + D+++ ++ Q +L E H
Sbjct: 926 SPTGNEAMVPSVCFTVPPPNKEAVDLAN-------------RIEQQYQNVLTLWHESHIN 972
Query: 2909 ANSVLQW--LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL 2966
SV+ W L ++ + +++ + S T Q SN L ++ + + +
Sbjct: 973 MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN---LQSRFEDFLEDSQESQVF 1029
Query: 2967 AGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 3026
+G +T + + QE L S A + + EES +L + +LR
Sbjct: 1030 SGSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRL 1079
Query: 3027 WLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086
E L+ + PL D + F + E E +++ E+L + G +T +
Sbjct: 1080 ENCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEE 1132
Query: 3087 SLSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL----- 3132
S + + ++ + + +N S+ ID+ ++K+TQ E L
Sbjct: 1133 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 1192
Query: 3133 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 3192
L E+ + + ++++ IST +KQ E E R L+ E+++A+ + DE+
Sbjct: 1193 TKLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 1248
Query: 3193 LIGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 3251
E+ L D K++ + + Q + +R+ L+ S + ++ + L W+
Sbjct: 1249 TYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ- 1307
Query: 3252 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 3311
++E Q ++QEN+ E +
Sbjct: 1308 -------------QVETTQRKIQENQP-----------------------------ENSK 1325
Query: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 3371
TL QL + K E+ K QS++ +C + A++Y V+D +A + +
Sbjct: 1326 TLATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1381
Query: 3372 TLDPVQLESSLLRSKAMLNEVEKRRS--------LLEILNSAADILINSSEADEDGIRDE 3423
+ PV+ + ++ E R+ + + + A D L E +E + +E
Sbjct: 1382 S--PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL-KRLEEEEKSLEEE 1438
Query: 3424 K-------AGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF 3476
K + + + +++ L+ + + + + E ++++ A +++F
Sbjct: 1439 KKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLF 1498
Query: 3477 DALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3536
A +++ +L Q + LQ Y F++ L + + + + VA
Sbjct: 1499 LAKHGDKMTDEERNELEKQVKTLQE-----SYNLLFSESLKQLQESQTSGDVKVEEKIVA 1553
Query: 3537 --QQEFLEVKQRVNSGCVMMENKLEG------IGQFHCRVREMFSQLADLDDELDG---- 3584
QQE+ E Q + EN+L G IG +++ S+ +L ++ G
Sbjct: 1554 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1613
Query: 3585 MGAIGRDTDSLQSQ------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
+ + ++T++ + ED L K++ K+ E + +E + +
Sbjct: 1614 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1673
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVE-DFYR---KLKGL----------NDAT 3684
K E E + K E K + E L L V+ D R K K + D
Sbjct: 1674 KEETEKV--AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGK 1731
Query: 3685 TAAEEAEA---------LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3735
+A E + + VGT E +NQQ K Q E++ + Q
Sbjct: 1732 SAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQSAQV 1790
Query: 3736 LIQSAGKDC---DVQGLEHDMEEINARWNTL---NKKVAQRIAQLQEALLHCGKFQDALE 3789
L++ G+ + + L+ +M+E+ + T ++K + LQE L KF
Sbjct: 1791 LLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---EKFDADYT 1847
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
WL +E+ + N + + + + +++ QK + K + + G R+ ++
Sbjct: 1848 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1907
Query: 3850 AE------------LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA 3897
A+ A ++ +L+ R+ L SK L+D++ + + + +
Sbjct: 1908 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1967
Query: 3898 EPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955
+ L E + SEP+ +Q+Q+ KAL+ I + V + K + L
Sbjct: 1968 CGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 2027
Query: 3956 SSLTS---PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW 4012
PA+ + + +D + RY ++ + L L+ + + E+L+W
Sbjct: 2028 LDARGSLLPAKNDI-QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2086
Query: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
+ VE L L + ++ L ++I R+ +++ + + ++ T
Sbjct: 2087 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPST 2146
Query: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+Q K+ + R+++ + + L +E+ + F++ E+L +L + L
Sbjct: 2147 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE- 2205
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL-VPWRAREGLDKLVSD 4191
G+ + + Q +E E +EH+ L+ ++ + + + +P L+K ++
Sbjct: 2206 --VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNN 2262
Query: 4192 ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-- 4249
++++K + DTI ++ + + + ++ ++ + +W+ ET +K+ + P +D
Sbjct: 2263 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 2322
Query: 4250 ---QTTAQLQVQKAFSIDIIRHKD----SMDELFSH------------------RSEIFG 4284
+ T +LQ + + I+ + S+ L S E
Sbjct: 2323 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2382
Query: 4285 TCGEE-----QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
T EE T +++ + YE + LL ++ A L + + E + W
Sbjct: 2383 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2442
Query: 4340 IE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL-- 4394
++ +T Q P+P D E ++ Q E+ + AE K +++K+ ++ +L EL
Sbjct: 2443 LQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFE---AELKQNVNKVQELKDKLTELLE 2498
Query: 4395 -NPEEGEMVEEKYQKAE--NMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
NP+ E K E + + ++ + R L+E+ + TQ +++ L
Sbjct: 2499 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2558
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
E + S L + P ++ R+ + + E +P +E L G+ ++ R G D
Sbjct: 2559 ELMVSVLGPLSIDPNMLNTQRQQV---QILLQEFATRKPQYEQLTAAGQGILSR-PGEDP 2614
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
L ++++L + W+ + + +R + + ++ + +L + D + +
Sbjct: 2615 SLRG-IVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKL 2673
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADL-IFACGETEKPEVRKS 4630
+ P + QQ+E A+ +K+E ++++ + L DL E K E+ +
Sbjct: 2674 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2733
Query: 4631 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL 4690
++ + +++++ + + ++ L+ A ++ Q+Q + WLD + P+ L
Sbjct: 2734 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2793
Query: 4691 NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN 4750
+ ++ + + K+F + Q EK +GE +L K T +++ ++ L +K W+
Sbjct: 2794 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK-TQGSEKAALQLQLNTIKTNWDT 2852
Query: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
+++ R++KL+ +L +++ +E L W+ + L+ + DP E +AK
Sbjct: 2853 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKL 2911
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
L+ ++ H VE +N N LL D E + +S++QK + +Q
Sbjct: 2912 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDK--------EVVTDENKSLIQKVDMVTEQ 2963
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQ----- 4925
L S + + ++F SK + + A+EQLD H L SQ
Sbjct: 2964 LHSKKFCLENMTQKFKEF----------QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 3013
Query: 4926 ----LKAKEETYNQLLDKGRL-------MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKM 4974
L+ ++++ L + L +++ DS S V + Q+ +S ++
Sbjct: 3014 YLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3073
Query: 4975 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
+E+ S LE L FQN+++E + + L+ +P T+ Q E K F
Sbjct: 3074 DEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK 3133
Query: 5035 EVNAHRDQIIELDQTGNQLKFLSQ-KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
++ A ++T + + D+V IK L ++ + K++ R+ R ++
Sbjct: 3134 KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 3193
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK----TLGGKQ 5149
KR ++F+ K+ L+ AE H +S+ + + + I QL+ K FQK L GKQ
Sbjct: 3194 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3253
Query: 5150 PVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
+ G+ L + +Q L++ L +V +W T+ K +R +L+EALL G+
Sbjct: 3254 QDVNW---LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3310
Query: 5210 FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 5269
F DAL++L+ W+ E +A +P + +V + K+ Q+ L R TV+V+KR G
Sbjct: 3311 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3370
Query: 5270 RELIENSRD-DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 5328
++ + D + QL L +RW+ + + ++ +LE A+ F +T+ L EW
Sbjct: 3371 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3430
Query: 5329 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 5388
L+ E+ L + L+ I HK + ++ AV++G+ + + +
Sbjct: 3431 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED 3490
Query: 5389 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI---------- 5438
++ + + + E+ + + L+ AL E EL+ W+
Sbjct: 3491 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKL 3550
Query: 5439 ------------QWAETTLIQRDQEPIPQNIDR--VKALIAEHQTFMEEMTRKQPDVDRV 5484
Q +E ++Q D QN+D+ + L QT +E+ Q ++ +
Sbjct: 3551 SVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 3610
Query: 5485 TKTYK 5489
YK
Sbjct: 3611 KARYK 3615
Score = 60.8 bits (146), Expect = 4e-08
Identities = 181/985 (18%), Positives = 364/985 (36%), Gaps = 178/985 (18%)
Query: 4666 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4723
+Q + +W+D ++L G+DL +V+ L K +E ++ ++ K++
Sbjct: 608 VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
Query: 4724 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4783
K T E H E+ K+ + E L L F + WL
Sbjct: 667 APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 715
Query: 4784 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4839
EE ++ D +A+ H L ++ + +++V + +LL +
Sbjct: 716 NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 770
Query: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4894
++ + AM W +LQ + EQ ++ + F+ E D+L L +
Sbjct: 771 -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 829
Query: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4953
+ S L + +E ++ EL + T L+ K + ++ L +S
Sbjct: 830 RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 885
Query: 4954 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4981
KT + + KW V+S E
Sbjct: 886 LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 945
Query: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041
+EA++LA + Q++ N LTL +S + + + NE++ R
Sbjct: 946 KEAVDLANRIE---QQYQNVLTLWHES-----------HINMKSVVSWHYLINEIDRIRA 991
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKRA 5097
+ +K + + ++ NL QSR+E ++ S E G + K
Sbjct: 992 SNVA------SIKTMLPGEHQQVLSNL----QSRFEDFLEDSQESQVFSGSDITQLEKEV 1041
Query: 5098 ---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTLG 5146
KQ+++ K + E ES + L + N D++ Q+ E
Sbjct: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE------ 1095
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ--------- 5197
+ ++++ R + E+ L ++ ++L + LG + +K + ++
Sbjct: 1096 -RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 1150
Query: 5198 ----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVMN 5243
+ + S ++D L+ + + L K+ E +L E++ V D + + N
Sbjct: 1151 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 1210
Query: 5244 LMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELSTR 5293
L+ K ++ E+ ++ L K E+ + ++ D W K + +L R
Sbjct: 1211 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 1270
Query: 5294 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSL 5352
W V ++ LE K + +RDT H L +W+ + E T R + P++++ L +
Sbjct: 1271 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1330
Query: 5353 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQ 5412
++ K + ++E K+ ++ E A + T+ + RA +
Sbjct: 1331 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------- 1378
Query: 5413 HQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 5472
QQ+ + ++A+L+ + ++ T L+ + I D +K L E ++ E
Sbjct: 1379 -QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1437
Query: 5473 EMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5531
E K+ V++ + K NI T ++ + G+ PP SE +
Sbjct: 1438 E---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIST 1483
Query: 5532 RINQLSARWQQVWLLALERQRKLND 5556
+ QLS Q + L + K+ D
Sbjct: 1484 KKEQLSEALQTIQLFLAKHGDKMTD 1508
Score = 51.6 bits (122), Expect = 2e-05
Identities = 138/725 (19%), Positives = 278/725 (38%), Gaps = 93/725 (12%)
Query: 4820 HQATVETVNKAGNELLESS------AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
HQ + + + LE S +G D + L + Q ++ +L+ E RE+Q +S
Sbjct: 1005 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE-REEQEES 1063
Query: 4874 TLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY---SQLKAKE 4930
+ SE+ + L L E +L T E+ D H ++ Q K K+
Sbjct: 1064 VYNL---YISEVRNIRLRLENCEDRLIRQ------IRTPLERDDLHESVFRITEQEKLKK 1114
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE------EA 4984
E +L D + ++ S + SV L + +VV M + S +
Sbjct: 1115 E-LERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT 1173
Query: 4985 LNLATEFQNSLQEFINW--LTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
+NL + + + + L E+ IA N + + I K + +EV+ R
Sbjct: 1174 VNLVLKNTQAAEALVKLYETKLCEEEAVIADK-----NNIENLISTLKQWRSEVDEKRQV 1228
Query: 5043 IIELDQTGNQLKFLSQKQ---------DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
L+ + K +S + D K + RW+ V + R R L+
Sbjct: 1229 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1288
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIK---LQLSKHKEFQKTLGGKQP 5150
K K + + + L DW++ E+ E N P+ K QL++ K + KQ
Sbjct: 1289 GKSLKYYRDTYHPLDDWIQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVSEIEMKQS 1346
Query: 5151 VYDTTIRTGR----ALKEKTL-------LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
D + +K+ L + + QK ++ D + + ++ + +
Sbjct: 1347 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1406
Query: 5200 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 5259
+ Q++ + L + E L E++ H ++ K QK + +
Sbjct: 1407 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH---------VEKAKELQKWVSNIS 1457
Query: 5260 GTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFR 5319
T++ +++G+ + + + + ++LS T+ +L ++K K + R
Sbjct: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI-QLFLAKHGD-----KMTDEER 1511
Query: 5320 DTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEV 5379
+ + ++ L E+ L +E+L+ L ++ KVEEK V E
Sbjct: 1512 NELEKQVKTLQESYNLL--------FSESLKQLQESQTSGDVKVEEKIV-AERQQEYKEK 1562
Query: 5380 ILAVCHPDCITTIKHWITIIRARF--EEVLTWAKQHQQRLETALSELVANAELLEELLA- 5436
+ +C D +T ++ + + F + K++Q + E ++ +A+ L E++
Sbjct: 1563 LQGIC--DLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKN 1620
Query: 5437 ---WIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI 5493
+++ L Q D+ I Q ++ K + E E ++K ++D+V T ++
Sbjct: 1621 TENFLKENGEKLSQEDKALIEQKLNEAK-IKCEQLNLKAEQSKK--ELDKVVTTAIKEET 1677
Query: 5494 EPTHA 5498
E A
Sbjct: 1678 EKVAA 1682
Score = 40.0 bits (92), Expect = 0.069
Identities = 37/141 (26%), Positives = 63/141 (44%), Gaps = 29/141 (20%)
Query: 5430 LLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME-EMTRKQPDVDRVTKTY 5488
++ L+ WI+ TT+ +R P N +KAL ++ F E E+ K+ + ++ + Y
Sbjct: 279 MVNYLIQWIRHHVTTMSERT---FPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLY 335
Query: 5489 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5548
K I +IE GR L Q P N + W ++ + L
Sbjct: 336 KLLEI------WIEF----GRIKLLQGYHP---------------NDIEKEWGKLIIAML 370
Query: 5549 ERQRKLNDALDRLEELKEFAN 5569
ER++ L ++RLE L++ AN
Sbjct: 371 EREKALRPEVERLEMLQQIAN 391
Score = 39.3 bits (90), Expect = 0.12
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363
K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + +
Sbjct: 590 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 648
Query: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423
EE + A + E+ + T + + +++ ++L ++ ++ L+T L
Sbjct: 649 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 703
Query: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483
V+ A L W+ E + D NI R K H M E+ +K+ ++
Sbjct: 704 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 757
Query: 5484 VTKTYKRKNIE 5494
V + ++ +E
Sbjct: 758 VQEIAEQLLLE 768
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 4237 bits (10988), Expect = 0.0
Identities = 2190/4089 (53%), Positives = 2948/4089 (72%), Gaps = 96/4089 (2%)
Query: 1905 RLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQ 1964
RL + ++E EK +H + + ++L+ WV N + L + + +
Sbjct: 1101 RLEEEEKSLEEEK----KEHVE---KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1153
Query: 1965 QYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQT 2024
+ ++ +K QL IQ F+++H ++ ++ ++ + + LQ S+ + ++
Sbjct: 1154 E-------ISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206
Query: 2025 AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 2084
Q+ Q +E +V Q++ ++L+ +C + Q E L GHQ D
Sbjct: 1207 LKQLQESQTSGDVKVEEKIVAERQQEYK---EKLQGICDLLTQTENRLIGHQEAFMIGDG 1263
Query: 2085 SA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE 2143
+ L+K QS ++LQ D+Q A + A VVK+ E F++EN KLS + + +KL++AK
Sbjct: 1264 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1323
Query: 2144 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 2203
+ E L + ++KEL++ VT+A+++ETEK A K+L E+K KI+ LLDW+++V +
Sbjct: 1324 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1383
Query: 2204 LLTNLPGMEQLSGASLEKG---------------ALDT-TDGYMGVNQAPEKLDKQCEMM 2247
T + + +G ++G L+T DG +G Q E L++Q + +
Sbjct: 1384 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKV 1441
Query: 2248 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 2307
KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ LQ+ + ELK Y T+LA+SE
Sbjct: 1442 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1501
Query: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV 2367
++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G L + LKRQ SFSEDV
Sbjct: 1502 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1561
Query: 2368 ISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNLVKDKLKDATERYTALHSKCT 2423
ISHKGDLR++TISG +VL+ S + GK + S V+ KL AT+R+ +L+SKC
Sbjct: 1562 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1621
Query: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
LG++L L+ +Y +++++ L A +QACEA K LS+ +A DP LQ QL TK LQ
Sbjct: 1622 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 1681
Query: 2484 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2543
+++ QV VEKL+K A +++ G P +Q+T D I+ ++ LS S+ ER+ LQ
Sbjct: 1682 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 1741
Query: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603
+ +S SVQ+ L+ +L +G VE +L+ + L+S +Q+ ++ N+ L+QDIA ++SS
Sbjct: 1742 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 1801
Query: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663
+ A E V +FMET D +TA+ LQ K+ ++S RF + + +E + +++L + E+FE+
Sbjct: 1802 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 1861
Query: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC 2723
LS KLQ F+E K++ L + P +D+T Q +QE E + +++L+ L L+ E+SS
Sbjct: 1862 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH 1921
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G D ++ NL K F E++ T+KE+++ +SCQEQLD F+ LV++ + W+KET
Sbjct: 1922 GLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTK 1981
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD---S 2840
+P + S A++L K +E K L + W+ K ++++N G SL NLI +T P +
Sbjct: 1982 KVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA 2041
Query: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900
K+G + + + + + K LT I+ DM+D++ YE LG +L ++ L L+
Sbjct: 2042 AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS 2101
Query: 2901 RMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQ 2960
++++ +E+++++QWL+ + +PT TE VK Q E NK+F AEL+QN K+Q
Sbjct: 2102 KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2161
Query: 2961 KVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020
++K+ L LL P++ EA WK++ E++S+W+ ++T+ RQ++LEES+++L FQ
Sbjct: 2162 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2221
Query: 3021 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080
E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+EF R+ Q+EQL A QGIL
Sbjct: 2222 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2281
Query: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140
+ PG+ V+++L ++ QKW LT +L+ R IDQAIVKSTQYQ LL+ LS+K+
Sbjct: 2282 SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2341
Query: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
+ +LS A+ST P+A+ QQLE +++ +++Q ++K AQ LC++LS L+ E+YLK
Sbjct: 2342 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2401
Query: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
EL ++LE + + +E A + + LQ+A AS+ QFQQM + + WLD K+ +Q K+
Sbjct: 2402 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2461
Query: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
PISAKL+ L+S ++++++F K+L S YE +AEGE+LLL G EK LQ QL +
Sbjct: 2462 PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ-GSEKAALQLQLNTI 2520
Query: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380
K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+ C+ + E++ LDP + E+
Sbjct: 2521 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 2580
Query: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440
S+ + K++ E+++ ++E+LN+ A+ L++ E D++ + DE + Q +D VTE+L +
Sbjct: 2581 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2640
Query: 3441 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 3500
K LE MTQ+ +EFQE K +++++ AK QL+I D+LGSQA SNK L L+ QQ+ LQ
Sbjct: 2641 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 2700
Query: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560
AL+ QVD + Q LV +A D S +L Q E QE + Q+V+ C +E KL+G
Sbjct: 2701 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 2760
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
IG F +REMFSQ A+ DDELD M +GRD ++LQ Q E ++ FL K+ L + +
Sbjct: 2761 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN 2820
Query: 3621 AECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679
C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR+EQ+E T+ R+E+FY KLK
Sbjct: 2821 KTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE 2880
Query: 3680 LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3739
+ AEE E Q VG E E INQQL FK+FQKE+++PLQ K Q VN LGQGLIQS
Sbjct: 2881 FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQS 2940
Query: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
A K QGLEHD++++NARW TLNKKVAQR AQLQEALLHCG+FQDALE LLSW+ DTE
Sbjct: 2941 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3000
Query: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
EL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV++++ EG +IA +AE AD+ KI
Sbjct: 3001 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3060
Query: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919
QL L+SRW LL+KA R +QLE I V+A+QFHET EP++++L+ EK+L N EP+GT
Sbjct: 3061 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT 3120
Query: 3920 QTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979
Q +K+++QI +HKALE+DI NH +HQAV IGQSL L+S ++ ++ K+D Q Y
Sbjct: 3121 QASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI 3180
Query: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DKLS + V+D+ + L +Q ++
Sbjct: 3181 EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE 3240
Query: 4040 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR 4099
L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+KL+ IK RY DIT S+ +
Sbjct: 3241 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300
Query: 4100 TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEH 4159
TLEQA QLA + ST+EEL WL +VE EL + Q GE+ Q Q R KELKKE +
Sbjct: 3301 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3360
Query: 4160 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
+ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ
Sbjct: 3361 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3420
Query: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK F+++I+RHKD +D+L
Sbjct: 3421 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3480
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
+I C EE+K +++K + +++ Y+ I +NSERY +LERAQ LVNQFWETYEEL PW
Sbjct: 3481 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3540
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 4399
+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKPHIDK+ K GPQL EL+P EG
Sbjct: 3541 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3600
Query: 4400 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLR 4459
++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ FHDKI+ +LE+LE + RLR
Sbjct: 3601 FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ---FHDKIDQILESLERIVERLR 3657
Query: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4519
PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RGEE+I RS G DKD++AK +Q
Sbjct: 3658 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 3717
Query: 4520 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI 4579
DKLDQMVF WE+I EERE K LDV+ELAEKFW D +L+ TIKDTQD + DLE PGI
Sbjct: 3718 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 3777
Query: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639
DPS++KQQ EAAETI+EE DGL EEL+ + LG++LI ACGE +KP V+KSIDE+N+AW+
Sbjct: 3778 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 3837
Query: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699
+LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D KL +M P+GTDL TVK Q+ E
Sbjct: 3838 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 3897
Query: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++PL ELK +W++L E+I +RQ
Sbjct: 3898 LKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQ 3957
Query: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
HKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GDPK IE+ELAKHHVL+NDVLA
Sbjct: 3958 HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLA 4017
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
HQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++VL+KTE+R+QQL L+QA+
Sbjct: 4018 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4077
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
GFH EIED LT E L ASKP GGLPETA+EQL+ HME+ + +AKEETY L+ K
Sbjct: 4078 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4137
Query: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFI 4999
G+ M L+R + + +Q + L++KW V +K+ ERK+KLEEALNLA EF NSLQ+FI
Sbjct: 4138 GQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4196
Query: 5000 NWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQK 5059
NWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+HR+QIIELD+TG LK+ SQK
Sbjct: 4197 NWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQK 4256
Query: 5060 QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD 5119
QDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQFHEAW KL++WLE++E LD
Sbjct: 4257 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4316
Query: 5120 SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179
SELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTGR+LKEKT L +D+ KLD+ L
Sbjct: 4317 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDML 4376
Query: 5180 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 5239
E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+DWLY+VEPQLAEDQPVHGD+D
Sbjct: 4377 SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID 4436
Query: 5240 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 5299
LVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD++WVK Q+QELSTRW+TVC
Sbjct: 4437 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4496
Query: 5300 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 5359
LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF G LPDD +AL++LID HKEF
Sbjct: 4497 LSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF 4556
Query: 5360 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
MKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITIIRARFEEVL WAKQHQQRL +
Sbjct: 4557 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4616
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+ VKALIAEHQTFMEEMTRKQP
Sbjct: 4617 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 4676
Query: 5480 DVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQ 5535
DVD+VTKTYKR+ +P +H P ++K R+ GRK + P +Q E KNPR+N
Sbjct: 4677 DVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPASSLYPSGSQTQIETKNPRVNL 4735
Query: 5536 LSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFR 5595
L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+WRKKYMRWMNHKKSRVMDFFR
Sbjct: 4736 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 4795
Query: 5596 RIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD 5655
RIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 4796 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 4855
Query: 5656 AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRS 5715
AY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 4856 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 4915
Query: 5716 TVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPS 5775
TVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL +GASQGM FR RGRRS+PS
Sbjct: 4916 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 4975
Query: 5776 SRAASPTRSSSSASQSNHSCTSMPSSPAT------------------------------- 5804
SR ASP RS+S +SQ+ + + P PAT
Sbjct: 4976 SRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAE 5033
Query: 5805 ----PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSAS 5860
P + P GSKL+ P + S + +G+ S + A+ +T AD KK+ S
Sbjct: 5034 CSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPS 5091
Query: 5861 RPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS---ESSAAGGQGNSRRGLNKPS 5917
RPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD ++ + SR KPS
Sbjct: 5092 RPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPS 5151
Query: 5918 KIPTMSKKT 5926
KIPT +K+
Sbjct: 5152 KIPTPQRKS 5160
Score = 716 bits (1847), Expect = 0.0
Identities = 792/3865 (20%), Positives = 1615/3865 (41%), Gaps = 324/3865 (8%)
Query: 1812 SYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIIS 1871
+Y+ L+ + + K Q E + + LC+ + + + ++ L+S + +++
Sbjct: 840 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV--- 896
Query: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV---LNQHTQLE 1928
+ Q+ ALE + + + + T+ R L F E V N H Q++
Sbjct: 897 ---DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 953
Query: 1929 GRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQ 1988
RL+DL + + L+ Y D P+ + Q++ IQ
Sbjct: 954 NRLRDL----------------------EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
Query: 1989 FFISEHAQDLSPQQNRQ-MLRLLNELQRSFQDILEQTAAQVDAL--QGHLQQMEQEALV- 2044
E+++ L+ Q N+Q ML E+++S D ++ A Q A LQ M A+V
Sbjct: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051
Query: 2045 ---------KTLQKQQNTCHQQLEDLCSWVGQAERAL------AGHQGRTTQQDLSALQK 2089
+ +Q + Q+ DL + + AG + +++ +L++
Sbjct: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1111
Query: 2090 NQSDLKDLQDDIQNRATSFATVVKDIE--GFMEENQTKLSPRELTALREKLHQA------ 2141
+ + + ++Q ++ + +KD E G ++ K+S E++ +E+L +A
Sbjct: 1112 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1171
Query: 2142 -----------------KEQYEALQEETRV----AQKELEEAVTSALQQETEKSKAAKEL 2180
++Q + LQE + + K+L+E+ TS + E+ A+
Sbjct: 1172 FLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKIVAERQ 1230
Query: 2181 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 2240
E K+K+ + D +T Q L G ++ A DG + + + K
Sbjct: 1231 QEYKEKLQGICDLLT-------QTENRLIGHQE---------AFMIGDGTVELKKYQSKQ 1274
Query: 2241 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK---EQ 2297
++ + M+ Q L +N + FL ++G L+ E++ +++QKL E K EQ
Sbjct: 1275 EELQKDMQGSAQALAEVVKN-------TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQ 1327
Query: 2298 YSTSLAQSEAELKQVQT--LQDELQKF-----LQDHK----EFESWLERSEKELE---NM 2343
+ QS+ EL +V T +++E +K L++ K WL +K+ E
Sbjct: 1328 LNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTK 1387
Query: 2344 HKG-------------------------------------GSSPETLPSLLKRQGSFSED 2366
HK G++ E L ++ + E
Sbjct: 1388 HKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEK 1447
Query: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
+IS + T S Q +L+ + + +E ++ +K+ LK E A K +L
Sbjct: 1448 IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE-LKVHYETALAESEKKMKL- 1505
Query: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
+ L + +F + W+Q E +E L + A D L +L K E++
Sbjct: 1506 --THSLQEELEKFDADYTEFEHWLQQSEQELENL--EAGADDINGLMTKLKRQKSFSEDV 1561
Query: 2487 AEHQ-------VPVEKLQKVARDIMEIEG---EPAPDHRHVQETTDSILSHFQSLSYSLA 2536
H+ + ++ + A+ + +G + + HR VQ D F+SL
Sbjct: 1562 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1621
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS---SLSSGVIQEALATNMKL 2593
+ L+ + + Q +++ LL + E K +S ++ +Q L L
Sbjct: 1622 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT-ASKHLSEPIAVDPKNLQRQLEETKAL 1680
Query: 2594 KQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSL 2651
+ I+ Q+ ++E ++ ++ S A +Q L ++ R+E L E+ L
Sbjct: 1681 QGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL 1740
Query: 2652 KKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED----QQ 2707
+ L ++ + ++ +M N L Q + T Q I N+ +E +Q
Sbjct: 1741 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNST-ALQDIISKNIMLEQDIAGRQ 1799
Query: 2708 ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEF 2767
+++ + V + Q ++++L F+E KE + +++ F
Sbjct: 1800 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 1859
Query: 2768 RKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTS 2827
L Q +L+ ++ TE + K++ + ++++ ++ +E
Sbjct: 1860 ENLSEKLQTFLETKTQAL--TEVDVPGKDVTELSQYMQESTSEFLEHKKHLE-------V 1910
Query: 2828 LENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGV 2887
L +L+ EI+ S G LPS D + ++++ K++++
Sbjct: 1911 LHSLLKEIS---SHG-----LPS---------------DKALVLEKTNNLSKKFKEMEDT 1947
Query: 2888 LHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKA 2947
+ E++E++ + +++ S+ W+ +E K + + E + E K
Sbjct: 1948 IKEKKEAVTSCQEQLDAFQVLVKSLKSWI---KETTKKVPIVQPSFGAEDLGKSLEDTKK 2004
Query: 2948 FLAELEQNSPKIQKVKE---ALAGLL--VTYPNSQEA-------------------ENW- 2982
+ +P+IQKV +L L+ VT P A E W
Sbjct: 2005 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2064
Query: 2983 -------KKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL--MEKEL 3033
KK +++ +E + + +L S L Q S + WL M K
Sbjct: 2065 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2124
Query: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQV 3093
P D + Q +Q K FEA +Q+ + + LT + + T +
Sbjct: 2125 TKWQQTPAPTDTEAVKTQVEQ----NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2180
Query: 3094 ---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 3150
++ L I+ KW EL R +++++ TQ+Q + L + + +SV
Sbjct: 2181 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2240
Query: 3151 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQ-YLKDELKKRLET 3209
+S P + Q ++ + + + ++ + GE L+ +K++L
Sbjct: 2241 PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2300
Query: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
V L +DR + + A+ + Q+Q + L L D ++ + + +S + +
Sbjct: 2301 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2360
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
QL+ ++ ++ + Q +V A E L V K L QL + ++++ +
Sbjct: 2361 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2420
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAML 3389
K + L+ + ++Q D W++ K + ++ + + SL++
Sbjct: 2421 KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDF 2480
Query: 3390 NEVEKRRSLL--EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEE 3447
++ +S + + + ++L+ + +++ ++ + I N D ++++ + L+E
Sbjct: 2481 SKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKE 2540
Query: 3448 MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVD 3507
++ +++E + + ++ ++ LE A ++ KL++ Q+ + V+
Sbjct: 2541 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 2600
Query: 3508 YLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR 3567
L N L+ D + + + Q+ V ++++S +EN + +F
Sbjct: 2601 LLNNTANSLLSVCE--IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEV 2658
Query: 3568 VREMFSQLADLDDELDGMGAIGRDTDS------LQSQIEDVRLFLNKIHVLK-----LDI 3616
+E QL ++LD ++G S LQ+Q + ++ +++ + K L +
Sbjct: 2659 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVV 2718
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK 3676
EAS++ +GT D+L ++E + ++ L+++ + LE L + F
Sbjct: 2719 EASDS--------KGTSDVL---LQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNT 2767
Query: 3677 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
++ + ++ VG + E + +Q K F K +++ L N + +
Sbjct: 2768 IREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK-KLEALMASNDNANKTCKMM 2826
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796
+ + D+ G++ D+E ++ + N L + R Q++ + +F L+ L
Sbjct: 2827 LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQ 2886
Query: 3797 DTEELIANQKPPSAEYKVVKAQIQEQKLLQR----LLDDRKATVDMLQAEGGRIAQSAEL 3852
EE +Q P E + + Q+ K+ Q+ L ++ V+ L G I +A+
Sbjct: 2887 KAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ--GLIQSAAKS 2944
Query: 3853 ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLA 3912
+ + L+ + +RW L K A R QL++ L+ +F + E + ++ TE+ +A
Sbjct: 2945 TSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3004
Query: 3913 NSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID 3972
N +P + ++ QI K L+ +++ + V + G+ +++ PA++ + +++
Sbjct: 3005 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3064
Query: 3973 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV 4032
L +R+ + ++ + L+ A+ F E + WL +E +L + +
Sbjct: 3065 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3124
Query: 4033 LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITV 4092
L Q A H AL ++I+N K++ QA+ GQ+L ++ E+ ++Q KLD + Y +I
Sbjct: 3125 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3184
Query: 4093 TSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKEL 4152
S L+QA A F EL WL EV ++L+ Q + E + + Q + L
Sbjct: 3185 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3244
Query: 4153 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGL----DKLVSDANEQYKLVSDTIGQRVD 4208
+++++ L V++ LEL+ + + DKL + +YK ++
Sbjct: 3245 QEDIL---LRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA-IKARYKDITKLSTDVAK 3300
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
++ A+Q +++ + W+ + + +L++ L+ ++ + K + +
Sbjct: 3301 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3360
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
K +D L S + + L++ ++Y +S +++ ++ A + Q
Sbjct: 3361 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3420
Query: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIG 4388
F + + WI ET + L ++ +Q Q + + I HK ID L+K G
Sbjct: 3421 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3480
Query: 4389 PQ-LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ + + EE + +++K K Y I + +R L L+ A S Q E ++++ P
Sbjct: 3481 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3540
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
L +++ S+L P L E + +R+ +++ + + +P + + + G +L+ S
Sbjct: 3541 LTETQSIISQLPAPAL---EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP 3597
Query: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567
G IQ+K + IK ++R + + + + +F + +L +++
Sbjct: 3598 G-----EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3652
Query: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK--- 4624
+ + S + IK+Q+ + + + + L E ++ G ++I G T+K
Sbjct: 3653 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 3712
Query: 4625 -PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683
V+ +D+M WEN++ +ER KL D M+ A ++ ++ + +T + +
Sbjct: 3713 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 3772
Query: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
G D + VK Q + + E+ Q E++ + + G ++ A E D+ I+++ + E
Sbjct: 3773 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI-AACGEPDKPIVKKSIDE 3831
Query: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
L W++L + R KLE A+ A Q+Q L+ + W+ L + PI D + +
Sbjct: 3832 LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 3891
Query: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLES-SAGDDASSLRSRLEAMNQCWESVLQ 4862
+ ++ + K++ Q +E +N LL+ + D +++ L + W+S+ +
Sbjct: 3892 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 3951
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4922
+ R+ +L+ L F +++ L LT E LS KP GG P+ +L H L
Sbjct: 3952 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4011
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
+ + A + T + ++K L+ S + + +L Q+W V K E+RK +L+
Sbjct: 4012 QNDVLAHQSTV-EAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4070
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
AL A F +++ WLT E+ L + P + T Q+ H A +
Sbjct: 4071 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET 4130
Query: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
L Q G Q+ K I + +++ +WE V + ER L++A A +FH
Sbjct: 4131 YKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4190
Query: 5103 AWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL 5162
+ + I+WL AE L+ S D + Q+ +HK F + + +TG L
Sbjct: 4191 SLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL 4250
Query: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
K + +D + N L V+ +W+ V + VER L++A + QF +A L++WL
Sbjct: 4251 KYFS-QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4309
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS--RDDT 5280
+ E L + + D D + + HK FQK LG + R+GR L E + DD
Sbjct: 4310 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4369
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
+ L EL +WDT+C SV +Q++LE+AL + F D + L++WL E L
Sbjct: 4370 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4429
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
+ D + + +LID HK F K++ ++ V + ++ D + +K + +
Sbjct: 4430 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKVQMQELS 4488
Query: 5401 ARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRV 5460
R+E V + Q RLE AL + ++ LL W+ AE TL R +P + D +
Sbjct: 4489 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTL--RFHGVLPDDEDAL 4546
Query: 5461 KALIAEHQTFMEEMTRKQPDVDRVT 5485
+ LI +H+ FM+++ K+ ++++ T
Sbjct: 4547 RTLIDQHKEFMKKLEEKRAELNKAT 4571
Score = 442 bits (1137), Expect = e-123
Identities = 584/3078 (18%), Positives = 1246/3078 (40%), Gaps = 292/3078 (9%)
Query: 1795 QNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDL 1854
Q TR L ++ + L L + N+E K+ + LN LQD++ + +LE+++
Sbjct: 1741 QITLTRSLSVQ--DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 1798
Query: 1855 TTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914
+ ++ E V + + + +L+ K+L S S L +
Sbjct: 1799 QSSINAMNEKVKKFM----ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL-- 1852
Query: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC-LQQY-EDLKQP 1972
KTKV E + L+ ++ K L +E+DV ++ L QY ++
Sbjct: 1853 --KTKV----ELFENLSEKLQTFLETKTQAL------TEVDVPGKDVTELSQYMQESTSE 1900
Query: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032
E K L+ L + E + P +L N L + F++ +E T
Sbjct: 1901 FLEHKKHLEVL----HSLLKEISSHGLPSDKALVLEKTNNLSKKFKE-MEDTI------- 1948
Query: 2033 GHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQS 2092
E++ V + Q+Q + ++ L SW+ + + + Q +DL K+
Sbjct: 1949 -----KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLE 2000
Query: 2093 DLKDLQD----------DIQNRATSFATVVKDI-------------------EGFMEENQ 2123
D K LQ+ + N S ++ + EG +
Sbjct: 2001 DTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2060
Query: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183
+ + LT++++ + YE L + EL + S LQ+ E+S
Sbjct: 2061 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL-SKLQKAQEES--------- 2110
Query: 2184 KKKIDALLDWVTSVGSSGGQ-LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 2242
A++ W+ + + + T P + +E+ + VN+ E DK
Sbjct: 2111 ----SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2166
Query: 2243 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ------QKLGELKE 2296
E+++ T A P +QML Q+L +L
Sbjct: 2167 LTELLEENPD------------TPEA------------PRWKQMLTEIDSKWQELNQLTI 2202
Query: 2297 QYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSL 2356
L +S L Q QT++ +L++ WL E + + P L +
Sbjct: 2203 DRQQKLEESSNNLTQFQTVEAQLKQ----------WLVEKELMVSVLGPLSIDPNMLNTQ 2252
Query: 2357 LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYT 2416
++ ++ + K +T +GQ +L + G++PS + +VK++L T+++
Sbjct: 2253 RQQVQILLQEFATRKPQYEQLTAAGQGILS-----RPGEDPS-LRGIVKEQLAAVTQKWD 2306
Query: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
+L + + ++ + + Q+Q+ SL + + + L+ V++ P + +QL
Sbjct: 2307 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA--VSTHPDAMNQQL 2364
Query: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
T +++++E+ + + ++ Q + D+ + E + + IL F+ +
Sbjct: 2365 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYL-KAELSRQLEGILKSFKDVEQKAE 2423
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
LQ A A S Q+ + ++ S V++ + + +
Sbjct: 2424 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2483
Query: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
+ Q E T + + A LQ +L + ++ Q +E+E+ LK+ L
Sbjct: 2484 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2543
Query: 2657 QA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2712
+A E E L + + N + + + + + +++ L EM+ ++
Sbjct: 2544 KALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE--NSIAKLKSLQKEMDQHFGMVEL 2601
Query: 2713 LEHLVTE-LSSCGFALDLCQHQDR-------------------VQNLRKDFTELQKTVKE 2752
L + LS C ++ +++ ++N+ + F E Q+ KE
Sbjct: 2602 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2661
Query: 2753 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812
++ +EQLD L Q + + + + S+ A L+ Q++ K L D
Sbjct: 2662 SKRQLQCAKEQLDIHDSL--GSQAYSNKYLTMLQTQQKSLQA--LKHQVDLAKRLAQDLV 2717
Query: 2813 -----SKG----------------TLVEEINCKGTSLE----------NLIMEITAP--- 2838
SKG TL ++++ K + LE N I E+ +
Sbjct: 2718 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 2777
Query: 2839 -----DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2893
DS G ++ ++ + K L + + N K K+ E
Sbjct: 2778 FDDELDSMAPVGRDAETLQKQKETIKAF--LKKLEALMASNDNAN-KTCKMMLATEETSP 2834
Query: 2894 SLQAILNRMEEVHKEANSVLQWLESKEE----VLKSMDAMSSPTK--------------- 2934
L I +E + K+ N +L +++EE +K ++ S K
Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 2894
Query: 2935 -------TETVKAQAESNKAF-LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQ 2986
TET+ Q K F E+E K Q V GL+ + S + +
Sbjct: 2895 QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL 2954
Query: 2987 EELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPN 3046
+++N+RW+ + R QL+E+ H FQ A L W+++ E ++ P S +
Sbjct: 2955 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3014
Query: 3047 MLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT--GPGDVSLSTSQVQKELQSINQKW 3104
++ AQ Q+ + + + + R+ E + + I T P D ++ K+L ++ +W
Sbjct: 3015 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD----KVKILKQLSLLDSRW 3070
Query: 3105 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 3164
L +K +R+ Q++ V + Q+ E L+ L+E + + +RL I TQ +++Q+
Sbjct: 3071 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3130
Query: 3165 ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADR 3224
+ + D+ + + +A ++ L VL + KD ++ +L+ + +++ + R
Sbjct: 3131 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED-KDMVQSKLDFSQVWYIEIQEKSHSR 3189
Query: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 3284
LQ AL + + F + EL WL++ + +K E L Q E Q+ +
Sbjct: 3190 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3249
Query: 3285 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 3344
+ + + G LL G+E +Q++L +K +++++K + D L+ +Q
Sbjct: 3250 LRKQNVDQALLNGLELLKQT-TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3308
Query: 3345 AQKYQWHVEDLVPWIEDCKAKMSELRV-TLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 3403
A++ E+L W++ + ++ L + + +R K + E + ++LL+ LN
Sbjct: 3309 ARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3368
Query: 3404 SAADILINSSE-ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREF-QESFKN 3461
+ L+ +G+ A N+ V++ + K ++ R ++F Q +
Sbjct: 3369 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3428
Query: 3462 IEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA-QQEVLQALEPQVDYLRNFTQGLVEDA 3520
+ E K + + D Q ++ L+ + E+L+ + D +++ + + A
Sbjct: 3429 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK--IMTA 3486
Query: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
+ + + + + + + Q + + +E + QF E++ L +
Sbjct: 3487 CSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQS 3546
Query: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE---EEGTLDLLG 3637
+ + A + ++L+ Q E+ R I K I+ +LE EG
Sbjct: 3547 IISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG----FS 3602
Query: 3638 LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV 3697
++ + A + ++ E K R L+ + + F+ K+ + ++ E +
Sbjct: 3603 IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI 3662
Query: 3698 GTEVEIINQQLADFK--MFQKEQVDPLQMKLQQVNGLGQGLIQSAG---KDCDVQGLEHD 3752
EVE I +Q+++ K E++ PL L+Q G+ +I +G KD + ++
Sbjct: 3663 SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ---RGEEMIARSGGTDKDISAKAVQDK 3719
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812
++++ W ++ V +R A+L + + KF L+ + DT++ I + + P +
Sbjct: 3720 LDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 3779
Query: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872
VVK Q + + ++ +D + +D++ G + + D+ + ++ L S W L
Sbjct: 3780 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 3839
Query: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI---- 3928
R +LE+ + A Q+ + + + D++ + KLA+ P+GT ++QQI
Sbjct: 3840 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 3899
Query: 3929 -IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+ +A ++ IE + HQA + L +T +++ + + + L+ + +++R
Sbjct: 3900 QFKSEAYQQQIEMERLN-HQAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 3955
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
+ L+ AL F E+L WL E LS + + A H L ++
Sbjct: 3956 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107
+ + V+ K G L++ + GEE +Q KL+ + R+ ++ + + + L+ A +
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4075
Query: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM----EHRLVL 4163
A F E+L WL + E L S P G +P+ + Q + EV
Sbjct: 4076 AKGFHGEIEDLQQWLTDTERHLLAS---KPLG-GLPETAKEQLNVHMEVCAAFEAKEETY 4131
Query: 4164 DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 4223
++ + + +L P A +D+ +++ E+++ V + +R +++ A+ + ++ +
Sbjct: 4132 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4191
Query: 4224 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF 4283
+ W+ + ++ L L D Q+ K F+ ++ H++ + EL + +
Sbjct: 4192 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4251
Query: 4284 GTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEET 4343
++ +++ S+ ++E + ER L+ A+ QF E + +L W+EE+
Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4311
Query: 4344 RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN--PEEGEM 4401
+ A D ++++ Q + ++ ++S+ D + G LKE ++
Sbjct: 4312 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4371
Query: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
+++ + + + I + +R L+EA+ S Q T D ++ +++ L + +L
Sbjct: 4372 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT---DALQALIDWLYRVEPQLAED 4428
Query: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521
+ ++D + I ++K+ EL K S +ALKR ELI +G+ D + ++Q
Sbjct: 4429 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQ-- 4483
Query: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4581
+ ++ WE + A + ++ + L AE+F + ALL + + + + D
Sbjct: 4484 MQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDE 4543
Query: 4582 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4641
++ ++ + ++ + EL +G ++ C ++ I + +E +
Sbjct: 4544 DALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEV 4603
Query: 4642 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD--NTVIKLCTMPPVGTDLNTVKDQLNE 4699
K+ ++L A+ + Q+ L+A+ WL T + + ++ VK + E
Sbjct: 4604 LAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 4663
Query: 4700 MKEFKVEVYQQQIEMEKL 4717
+ F E+ ++Q +++K+
Sbjct: 4664 HQTFMEEMTRKQPDVDKV 4681
Score = 404 bits (1039), Expect = e-111
Identities = 676/3612 (18%), Positives = 1415/3612 (39%), Gaps = 437/3612 (12%)
Query: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
++ L+K+ QN +++ +DL +WV + + L RT SDL
Sbjct: 259 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 305
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149
++ ++N + +++ E ++E K+S ++TA EKLH+ + QY L
Sbjct: 306 PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 362
Query: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201
+R ++ L+ V+ A + E E+ + A + +E I D+ +
Sbjct: 363 NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 422
Query: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258
Q N+ +++++ L + A T + Y Q Q C+ ++ +E +
Sbjct: 423 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 482
Query: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317
+ F N E L+ ++ +YS + S +L+ VQ +
Sbjct: 483 EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526
Query: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368
E ++ LQ + + +++ ++ + P +K + + I
Sbjct: 527 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
Query: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421
SH+ + ++ +G + + F KE ++ N ++ + ++ T H
Sbjct: 587 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 642
Query: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480
SH+NM + +H N D ++A + A+++ +L PG Q+ L+ +
Sbjct: 643 -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 687
Query: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540
E+ E + DI ++E E ++ QE S AER
Sbjct: 688 SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 733
Query: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593
Q +SV S +++I +N E + + + + + ++ L ++ KL
Sbjct: 734 -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 786
Query: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649
K+++ R K L T + F + A S++ L+ +L V Q Q+ +K
Sbjct: 787 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 846
Query: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709
++ +L + E L + + + ++A N +I + +++ E++++++
Sbjct: 847 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 902
Query: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
LE + + + LD H+++ L + + + + R +D
Sbjct: 903 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 962
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
+ L +R W+++ E + K E Q E+ K+L + LV E
Sbjct: 963 GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
Query: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874
I K + ++ T D + +T + V S S V I +
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 2875 SDVNLKYEKL-----------GGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL 2923
D+ +Y L G L +E +++ +E ++A + +W+ + + L
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1134
Query: 2924 KSMDAMSSP-------------TKTETVKAQAESNKAFLAEL--EQNSPKIQKVKEALAG 2968
K + P TK E + ++ + FLA+ + + ++++ +
Sbjct: 1135 KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1194
Query: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ------------LEESASHLAC 3016
L +Y N +E+ K++QE S + E VA ++Q L ++ + L
Sbjct: 1195 LQESY-NLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIG 1253
Query: 3017 FQAA-----------ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEAR 3065
Q A + Q + ++K++ + N N K+ + + +E +A
Sbjct: 1254 HQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1313
Query: 3066 RQQH--------EQLNEAAQ-------GILTGPGDVSLSTSQVQKELQSINQK------W 3104
+Q EQLN A+ ++T K+L+ K W
Sbjct: 1314 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1373
Query: 3105 VELTDKLNSRSSQIDQAIVK--STQYQE--LLQDLSEKVRAVGQRL--SVQSAISTQPEA 3158
+ DK + R+ + +++ T +QE + E+ G L V + T E
Sbjct: 1374 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1433
Query: 3159 VKQQLEET----SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 3214
+ QQ ++ +I S + + + AQ L ++ QYL E K++L+ L
Sbjct: 1434 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQG-----QYLSPEEKEKLQKNMKEL 1488
Query: 3215 QGLEDLAADRINRLQAALASTQQFQQMFD----ELRTWLDDKQSQQAKNCPISA-KLERL 3269
+ + A + S Q+ + FD E WL + Q+ +N A + L
Sbjct: 1489 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE-QELENLEAGADDINGL 1547
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS-----------VPPGEEKRTLQNQLV 3318
++L+ + F + + H G I G +L + V R +Q +L
Sbjct: 1548 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1607
Query: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE---LRVTLDP 3375
+ + L K + LKD + K Q Y+ L+ ++ C+A S+ + +DP
Sbjct: 1608 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 1667
Query: 3376 VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI----------NSSEADEDGIRDEKA 3425
L+ L +KA+ ++ ++ +E L A++L+ N + D I
Sbjct: 1668 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 1727
Query: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALGSQAC 3484
++++++ E+LQ + L E + N+E + K Q ++ ++ Q
Sbjct: 1728 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL---KEQGQVPLNSTALQDI 1784
Query: 3485 SNKNL---EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL 3541
+KN+ + + +Q + A+ +V T D S AS L + + F
Sbjct: 1785 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETT--------DPSTASSLQAKMKDLSARFS 1836
Query: 3542 EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIED 3601
E + ME + E+F L ++ LQ+ +E
Sbjct: 1837 EASHKHKETLAKMEELKTKV--------ELFENL----------------SEKLQTFLET 1872
Query: 3602 VRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQE 3661
L ++ D+ + +E T + L K+ LE L+ +++ G +
Sbjct: 1873 KTQALTEV-----DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDK 1927
Query: 3662 QLELTLGRVEDFYRKLKGLND--------ATTAAEEAEALQ--------WVVGTE----- 3700
L L + + +K K + D T+ E+ +A Q W+ T
Sbjct: 1928 --ALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI 1985
Query: 3701 ------VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL----------------IQ 3738
E + + L D K Q E+ ++Q+VN G L ++
Sbjct: 1986 VQPSFGAEDLGKSLEDTKKLQ-EKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVK 2044
Query: 3739 SAGKDCDVQG----------------LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
S G + +G ++ DM +I+ + L + +IA+L L
Sbjct: 2045 SGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQ 2104
Query: 3783 KFQDALEPLLSWLADTEELIA--NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
K Q+ ++ WL + Q P + + VK Q+++ K + L V L+
Sbjct: 2105 KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELK 2164
Query: 3841 AE-GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3899
+ + ++ + + + L ++S+W EL RQ++LE+ QF
Sbjct: 2165 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQ 2224
Query: 3900 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL- 3958
+ +L E ++ P+ + Q + + L ++ Q GQ + S
Sbjct: 2225 LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRP 2284
Query: 3959 -TSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
P+ +G++ E++ ++ ++ + + + +DQA+ + + + + L++++
Sbjct: 2285 GEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLD 2344
Query: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTTGEEVL 4074
+KLSS D +++Q + +EI KK IK QAL L EE L
Sbjct: 2345 NKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQ----IKVAQALCEDLSALVKEEYL 2400
Query: 4075 L--IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+ +L+GI + D+ + ++ L+ A + +FQ + WL +EE S
Sbjct: 2401 KAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKS 2460
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA 4192
S + + + K+ K + + + LL + L ++
Sbjct: 2461 HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTI 2520
Query: 4193 NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL----MALGPIRLEQ 4248
+ + + +R +++ +++++ +Y++ + W+ + + L L P E
Sbjct: 2521 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP--AEG 2578
Query: 4249 DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 4308
+ + A+L K+ ++ +H ++ L + + + C E K V+ ++ +SLIQ+ + +
Sbjct: 2579 ENSIAKL---KSLQKEMDQHFGMVELLNNTANSLLSVC-EIDKEVVTDENKSLIQKVDMV 2634
Query: 4309 S-LLNSERYARLERAQVLVNQFWETYEELSPWIE---ETRALIAQLPSPAIDHEQLRQQQ 4364
+ L+S+++ LE +F E +E ++ E + L S A ++ L Q
Sbjct: 2635 TEQLHSKKFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 2693
Query: 4365 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
+ + L+ +H+ + K L ++ + + V + + ++ + ++V ++
Sbjct: 2694 TQQKSLQ--ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 2751
Query: 4425 LALDEAVS-----QST------QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 4473
L+ + Q+T Q EF D+++ M + + + I A + K+
Sbjct: 2752 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 2811
Query: 4474 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4533
++ N +A K A + +L+G + D + +K+ LD
Sbjct: 2812 LMASNDNA----NKTCKMMLATEETSPDLVGIKR--DLEALSKQCNKLLD---------- 2855
Query: 4534 ARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET 4593
RA+ RE + ++ E+F+ + ++ ++ G++ I QQ+ +
Sbjct: 2856 -RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 2914
Query: 4594 I-KEETDGLHEELEFIRILGADLI-FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4651
KEE + L + + + LG LI A T + +D++N W+ LNK +R +
Sbjct: 2915 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 2974
Query: 4652 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4711
L++A+ ++QD L+++ W+ +T + P + VK Q+ E K + + ++
Sbjct: 2975 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRK 3034
Query: 4712 IEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771
+E + +GE + A + D+ I + L+ L WE L K R +LEG + Q
Sbjct: 3035 STVEVIKREGEKIATTA-EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3093
Query: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
F LE L WLT E+ L PI +E ++A+H L++D++ H + G
Sbjct: 3094 FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3153
Query: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L S+ +D ++S+L+ + + +K+ R + LQ L A+ F + + +
Sbjct: 3154 QSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNW 3213
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + +LS E +Q L + +++ +Q L G L LL +
Sbjct: 3214 LNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNG-LELLKQTTGD 3272
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
+ + ++ ++ ++ + LE+AL LA ++ +E WL E L +
Sbjct: 3273 EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL-L 3331
Query: 5012 ASPPSLILNTVLSQIE-EHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLV 5070
+ ++ SQ + K E ++ + L++ + L L + ++ ++
Sbjct: 3332 SYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVA 3391
Query: 5071 SVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
R+ V ++ +D A R++QF +A + W+ + E L S +I + D+
Sbjct: 3392 EDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3451
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
QL K F + + + D +++G + E+ Q + L +V +DT+C
Sbjct: 3452 TSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM-TACSEEEKQSMKKKLDKVLKNYDTIC 3510
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
+ ER +LE A QF + + L WL + + +++ + + + + H+
Sbjct: 3511 QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQ 3570
Query: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
++ + + + + ++G +L+E S + ++ + T + + + + L++
Sbjct: 3571 LRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDE 3630
Query: 5311 ALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
A+ Q+ F D + +LE L + LR ++ + E ++ I +K +E+ +
Sbjct: 3631 AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLY 3690
Query: 5371 NSAVAMGEVILA 5382
+ GE ++A
Sbjct: 3691 ETLKQRGEEMIA 3702
Score = 381 bits (978), Expect = e-104
Identities = 610/3185 (19%), Positives = 1269/3185 (39%), Gaps = 392/3185 (12%)
Query: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
+SSLL + + + + + ++ LL + E++ L+ + S D+
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 305
Query: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2653
+S LE + V R +E +S+ + + K++E+ Q L L EK ES K
Sbjct: 306 PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 360
Query: 2654 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2701
LL + E L F+ + L N+ +++ + + N+
Sbjct: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
Query: 2702 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2735
E++ ++EN+ +++ + +L + + L LCQ ++
Sbjct: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
Query: 2736 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792
N K+ T+ + +K+ + SC ++ KL Q+ ++E E + T
Sbjct: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 539
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2848
+ K I LK D K ++ + C +E I + + A +S ++
Sbjct: 540 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 599
Query: 2849 PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2908
G+ + T + D+++ ++ Q +L E H
Sbjct: 600 SPTGNEAMVPSVCFTVPPPNKEAVDLAN-------------RIEQQYQNVLTLWHESHIN 646
Query: 2909 ANSVLQW--LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL 2966
SV+ W L ++ + +++ + S T Q SN L ++ + + +
Sbjct: 647 MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN---LQSRFEDFLEDSQESQVF 703
Query: 2967 AGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 3026
+G +T + + QE L S A + + EES +L + +LR
Sbjct: 704 SGSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRL 753
Query: 3027 WLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086
E L+ + PL D + F + E E +++ E+L + G +T +
Sbjct: 754 ENCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEE 806
Query: 3087 SLSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL----- 3132
S + + ++ + + +N S+ ID+ ++K+TQ E L
Sbjct: 807 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 866
Query: 3133 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 3192
L E+ + + ++++ IST +KQ E E R L+ E+++A+ + DE+
Sbjct: 867 TKLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
Query: 3193 LIGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 3251
E+ L D K++ + + Q + +R+ L+ S + ++ + L W+
Sbjct: 923 TYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ- 981
Query: 3252 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 3311
++E Q ++QEN+ E +
Sbjct: 982 -------------QVETTQRKIQENQP-----------------------------ENSK 999
Query: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 3371
TL QL + K E+ K QS++ +C + A++Y V+D +A + +
Sbjct: 1000 TLATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQK 1055
Query: 3372 TLDPVQLESSLLRSKAMLNEVEKRRS--------LLEILNSAADILINSSEADEDGIRDE 3423
+ PV+ + ++ E R+ + + + A D L E +E + +E
Sbjct: 1056 S--PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL-KRLEEEEKSLEEE 1112
Query: 3424 K-------AGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF 3476
K + + + +++ L+ + + + + E ++++ A +++F
Sbjct: 1113 KKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLF 1172
Query: 3477 DALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3536
A +++ +L Q + LQ Y F++ L + + + + VA
Sbjct: 1173 LAKHGDKMTDEERNELEKQVKTLQE-----SYNLLFSESLKQLQESQTSGDVKVEEKIVA 1227
Query: 3537 --QQEFLEVKQRVNSGCVMMENKLEG------IGQFHCRVREMFSQLADLDDELDG---- 3584
QQE+ E Q + EN+L G IG +++ S+ +L ++ G
Sbjct: 1228 ERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA 1287
Query: 3585 MGAIGRDTDSLQSQ------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
+ + ++T++ + ED L K++ K+ E + +E + +
Sbjct: 1288 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAI 1347
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVE-DFYR---KLKGL----------NDAT 3684
K E E + K E K + E L L V+ D R K K + D
Sbjct: 1348 KEETEKV--AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGK 1405
Query: 3685 TAAEEAEA---------LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3735
+A E + + VGT E +NQQ K Q E++ + Q
Sbjct: 1406 SAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA-QHEKIISQHQAVIIATQSAQV 1464
Query: 3736 LIQSAGKDC---DVQGLEHDMEEINARWNTL---NKKVAQRIAQLQEALLHCGKFQDALE 3789
L++ G+ + + L+ +M+E+ + T ++K + LQE L KF
Sbjct: 1465 LLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---EKFDADYT 1521
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
WL +E+ + N + + + + +++ QK + K + + G R+ ++
Sbjct: 1522 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1581
Query: 3850 AE------------LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA 3897
A+ A ++ +L+ R+ L SK L+D++ + + + +
Sbjct: 1582 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1641
Query: 3898 EPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955
+ L E + SEP+ +Q+Q+ KAL+ I + V + K + L
Sbjct: 1642 CGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVL 1701
Query: 3956 SSLTS---PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW 4012
PA+ + + +D + RY ++ + L L+ + + E+L+W
Sbjct: 1702 LDARGSLLPAKNDI-QKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 1760
Query: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
+ VE L L + ++ L ++I R+ +++ + + ++ T
Sbjct: 1761 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPST 1820
Query: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
+Q K+ + R+++ + + L +E+ + F++ E+L +L + L
Sbjct: 1821 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE- 1879
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL-VPWRAREGLDKLVSD 4191
G+ + + Q +E E +EH+ L+ ++ + + + +P L+K ++
Sbjct: 1880 --VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNN 1936
Query: 4192 ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-- 4249
++++K + DTI ++ + + + ++ ++ + +W+ ET +K+ + P +D
Sbjct: 1937 LSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG 1996
Query: 4250 ---QTTAQLQVQKAFSIDIIRHKD----SMDELFSH------------------RSEIFG 4284
+ T +LQ + + I+ + S+ L S E
Sbjct: 1997 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTA 2056
Query: 4285 TCGEE-----QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
T EE T +++ + YE + LL ++ A L + + E + W
Sbjct: 2057 TNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2116
Query: 4340 IE---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL-- 4394
++ +T Q P+P D E ++ Q E+ + AE K +++K+ ++ +L EL
Sbjct: 2117 LQKMNKTATKWQQTPAPT-DTEAVKTQVEQNKSFE---AELKQNVNKVQELKDKLTELLE 2172
Query: 4395 -NPEEGEMVEEKYQKAE--NMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
NP+ E K E + + ++ + R L+E+ + TQ +++ L
Sbjct: 2173 ENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEK 2232
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
E + S L + P ++ R+ + + E +P +E L G+ ++ R G D
Sbjct: 2233 ELMVSVLGPLSIDPNMLNTQRQQV---QILLQEFATRKPQYEQLTAAGQGILSR-PGEDP 2288
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
L ++++L + W+ + + +R + + ++ + +L + D + +
Sbjct: 2289 SLRG-IVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKL 2347
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADL-IFACGETEKPEVRKS 4630
+ P + QQ+E A+ +K+E ++++ + L DL E K E+ +
Sbjct: 2348 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2407
Query: 4631 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL 4690
++ + +++++ + + ++ L+ A ++ Q+Q + WLD + P+ L
Sbjct: 2408 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2467
Query: 4691 NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN 4750
+ ++ + + K+F + Q EK +GE +L K T +++ ++ L +K W+
Sbjct: 2468 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK-TQGSEKAALQLQLNTIKTNWDT 2526
Query: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
+++ R++KL+ +L +++ +E L W+ + L+ + DP E +AK
Sbjct: 2527 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKL 2585
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
L+ ++ H VE +N N LL D E + +S++QK + +Q
Sbjct: 2586 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDK--------EVVTDENKSLIQKVDMVTEQ 2637
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQ----- 4925
L S + + ++F SK + + A+EQLD H L SQ
Sbjct: 2638 LHSKKFCLENMTQKFKEF----------QEVSKESKRQLQCAKEQLDIHDSLGSQAYSNK 2687
Query: 4926 ----LKAKEETYNQLLDKGRL-------MLLSRDDSGSGSKTEQSVALLEQKWHVVSSKM 4974
L+ ++++ L + L +++ DS S V + Q+ +S ++
Sbjct: 2688 YLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 2747
Query: 4975 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
+E+ S LE L FQN+++E + + L+ +P T+ Q E K F
Sbjct: 2748 DEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK 2807
Query: 5035 EVNAHRDQIIELDQTGNQLKFLSQ-KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
++ A ++T + + D+V IK L ++ + K++ R+ R ++
Sbjct: 2808 KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 2867
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK----TLGGKQ 5149
KR ++F+ K+ L+ AE H +S+ + + + I QL+ K FQK L GKQ
Sbjct: 2868 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 2927
Query: 5150 PVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
+ G+ L + +Q L++ L +V +W T+ K +R +L+EALL G+
Sbjct: 2928 QDVNW---LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 2984
Query: 5210 FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 5269
F DAL++L+ W+ E +A +P + +V + K+ Q+ L R TV+V+KR G
Sbjct: 2985 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3044
Query: 5270 RELIENSRD-DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 5328
++ + D + QL L +RW+ + + ++ +LE A+ F +T+ L EW
Sbjct: 3045 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3104
Query: 5329 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 5388
L+ E+ L + L+ I HK + ++ AV++G+ + + +
Sbjct: 3105 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRED 3164
Query: 5389 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI---------- 5438
++ + + + E+ + + L+ AL E EL+ W+
Sbjct: 3165 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKL 3224
Query: 5439 ------------QWAETTLIQRDQEPIPQNIDR--VKALIAEHQTFMEEMTRKQPDVDRV 5484
Q +E ++Q D QN+D+ + L QT +E+ Q ++ +
Sbjct: 3225 SVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI 3284
Query: 5485 TKTYK 5489
YK
Sbjct: 3285 KARYK 3289
Score = 60.8 bits (146), Expect = 4e-08
Identities = 181/985 (18%), Positives = 364/985 (36%), Gaps = 178/985 (18%)
Query: 4666 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4723
+Q + +W+D ++L G+DL +V+ L K +E ++ ++ K++
Sbjct: 282 VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340
Query: 4724 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4783
K T E H E+ K+ + E L L F + WL
Sbjct: 341 APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 389
Query: 4784 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4839
EE ++ D +A+ H L ++ + +++V + +LL +
Sbjct: 390 NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 444
Query: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4894
++ + AM W +LQ + EQ ++ + F+ E D+L L +
Sbjct: 445 -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 503
Query: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4953
+ S L + +E ++ EL + T L+ K + ++ L +S
Sbjct: 504 RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 559
Query: 4954 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4981
KT + + KW V+S E
Sbjct: 560 LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 619
Query: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041
+EA++LA + Q++ N LTL +S + + + NE++ R
Sbjct: 620 KEAVDLANRIE---QQYQNVLTLWHES-----------HINMKSVVSWHYLINEIDRIRA 665
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKRA 5097
+ +K + + ++ NL QSR+E ++ S E G + K
Sbjct: 666 SNVA------SIKTMLPGEHQQVLSNL----QSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 5098 ---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTLG 5146
KQ+++ K + E ES + L + N D++ Q+ E
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE------ 769
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ--------- 5197
+ ++++ R + E+ L ++ ++L + LG + +K + ++
Sbjct: 770 -RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824
Query: 5198 ----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVMN 5243
+ + S ++D L+ + + L K+ E +L E++ V D + + N
Sbjct: 825 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 884
Query: 5244 LMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELSTR 5293
L+ K ++ E+ ++ L K E+ + ++ D W K + +L R
Sbjct: 885 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 944
Query: 5294 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSL 5352
W V ++ LE K + +RDT H L +W+ + E T R + P++++ L +
Sbjct: 945 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1004
Query: 5353 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQ 5412
++ K + ++E K+ ++ E A + T+ + RA +
Sbjct: 1005 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------- 1052
Query: 5413 HQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 5472
QQ+ + ++A+L+ + ++ T L+ + I D +K L E ++ E
Sbjct: 1053 -QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1111
Query: 5473 EMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5531
E K+ V++ + K NI T ++ + G+ PP SE +
Sbjct: 1112 E---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIST 1157
Query: 5532 RINQLSARWQQVWLLALERQRKLND 5556
+ QLS Q + L + K+ D
Sbjct: 1158 KKEQLSEALQTIQLFLAKHGDKMTD 1182
Score = 51.6 bits (122), Expect = 2e-05
Identities = 138/725 (19%), Positives = 278/725 (38%), Gaps = 93/725 (12%)
Query: 4820 HQATVETVNKAGNELLESS------AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
HQ + + + LE S +G D + L + Q ++ +L+ E RE+Q +S
Sbjct: 679 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE-REEQEES 737
Query: 4874 TLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY---SQLKAKE 4930
+ SE+ + L L E +L T E+ D H ++ Q K K+
Sbjct: 738 VYNL---YISEVRNIRLRLENCEDRLIRQ------IRTPLERDDLHESVFRITEQEKLKK 788
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE------EA 4984
E +L D + ++ S + SV L + +VV M + S +
Sbjct: 789 E-LERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT 847
Query: 4985 LNLATEFQNSLQEFINW--LTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
+NL + + + + L E+ IA N + + I K + +EV+ R
Sbjct: 848 VNLVLKNTQAAEALVKLYETKLCEEEAVIADK-----NNIENLISTLKQWRSEVDEKRQV 902
Query: 5043 IIELDQTGNQLKFLSQKQ---------DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
L+ + K +S + D K + RW+ V + R R L+
Sbjct: 903 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 962
Query: 5094 RKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIK---LQLSKHKEFQKTLGGKQP 5150
K K + + + L DW++ E+ E N P+ K QL++ K + KQ
Sbjct: 963 GKSLKYYRDTYHPLDDWIQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVSEIEMKQS 1020
Query: 5151 VYDTTIRTGR----ALKEKTL-------LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
D + +K+ L + + QK ++ D + + ++ + +
Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTR 1080
Query: 5200 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRT 5259
+ Q++ + L + E L E++ H ++ K QK + +
Sbjct: 1081 YTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH---------VEKAKELQKWVSNIS 1131
Query: 5260 GTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFR 5319
T++ +++G+ + + + + ++LS T+ +L ++K K + R
Sbjct: 1132 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI-QLFLAKHGD-----KMTDEER 1185
Query: 5320 DTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEV 5379
+ + ++ L E+ L +E+L+ L ++ KVEEK V E
Sbjct: 1186 NELEKQVKTLQESYNLL--------FSESLKQLQESQTSGDVKVEEKIV-AERQQEYKEK 1236
Query: 5380 ILAVCHPDCITTIKHWITIIRARF--EEVLTWAKQHQQRLETALSELVANAELLEELLA- 5436
+ +C D +T ++ + + F + K++Q + E ++ +A+ L E++
Sbjct: 1237 LQGIC--DLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKN 1294
Query: 5437 ---WIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI 5493
+++ L Q D+ I Q ++ K + E E ++K ++D+V T ++
Sbjct: 1295 TENFLKENGEKLSQEDKALIEQKLNEAK-IKCEQLNLKAEQSKK--ELDKVVTTAIKEET 1351
Query: 5494 EPTHA 5498
E A
Sbjct: 1352 EKVAA 1356
Score = 39.3 bits (90), Expect = 0.12
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363
K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + +
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 322
Query: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423
EE + A + E+ + T + + +++ ++L ++ ++ L+T L
Sbjct: 323 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 377
Query: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483
V+ A L W+ E + D NI R K H M E+ +K+ ++
Sbjct: 378 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 431
Query: 5484 VTKTYKRKNIE 5494
V + ++ +E
Sbjct: 432 VQEIAEQLLLE 442
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 376 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 435
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2832
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 436 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 487
Query: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2892
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 488 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 543
Query: 2893 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2950
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 544 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 603
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2991
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 604 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 663
Query: 2992 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 3024
T+ TV ++RQ+ + ++L
Sbjct: 664 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 723
Query: 3025 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 3083
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 724 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 783
Query: 3084 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 784 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 842
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 3202
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 843 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 881
Query: 3203 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 3241
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 882 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 939
Query: 3242 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 3300
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 940 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 997
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 998 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1057
Query: 3361 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 3418
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 1058 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1117
Query: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 3477
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1118 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1177
Query: 3478 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1178 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1236
Query: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1237 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1289
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3654
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1290 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1348
Query: 3655 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3714
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1349 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1388
Query: 3715 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3772
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1389 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1435
Query: 3773 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1436 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1495
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1496 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1555
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1556 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1615
Query: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1616 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1674
Query: 4001 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 4058
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1675 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1727
Query: 4059 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 4116
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1728 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1787
Query: 4117 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 4167
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1788 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1847
Query: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 4222
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1848 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1905
Query: 4223 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1906 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1957
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
F Q ++E+T ++ + + + + + + +S
Sbjct: 1958 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2002
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 4398
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 2003 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2062
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 4458
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 2063 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2119
Query: 4459 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4516
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2120 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2172
Query: 4517 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4576
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2173 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2231
Query: 4577 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4634
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2232 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2290
Query: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4694
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2291 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2347
Query: 4695 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4739
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2348 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2407
Query: 4740 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4772
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2408 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2467
Query: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2468 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2527
Query: 4833 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2528 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2587
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2588 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2646
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2647 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2706
Query: 5012 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 5064
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2707 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2766
Query: 5065 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2767 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2826
Query: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 5170
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2827 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2886
Query: 5171 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 5225
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2887 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2946
Query: 5226 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 5283
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2947 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3005
Query: 5284 KGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
L++L+TRW L V+ + R+ Q
Sbjct: 3006 LSTLEDLNTRWKL---LQVAVEDRVRQ 3029
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2772 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2828
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 320 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 374
Query: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2888
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 375 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 430
Query: 2889 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2948
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 431 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 488
Query: 2949 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2998
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 489 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 548
Query: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 3057
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 549 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 597
Query: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 3117
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 598 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 656
Query: 3118 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 3171
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 657 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 715
Query: 3172 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 3213
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 716 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 775
Query: 3214 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 3258
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 776 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 835
Query: 3259 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 836 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 892
Query: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 3364
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 893 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 952
Query: 3365 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 3421
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 953 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1011
Query: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 3480
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 1012 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1071
Query: 3481 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3540
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 1072 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1130
Query: 3541 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3600
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1131 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1190
Query: 3601 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3660
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1191 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1250
Query: 3661 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
+ LE + L+ N E + E I++ L + + D
Sbjct: 1251 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1310
Query: 3721 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1311 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1361
Query: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3839
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1362 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1419
Query: 3840 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3897
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1420 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1459
Query: 3898 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1460 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1519
Query: 3954 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 4013
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1520 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1579
Query: 4014 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1580 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1638
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1639 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1698
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1699 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1753
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 4253
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1754 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1807
Query: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1808 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1858
Query: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 4373
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1859 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1917
Query: 4374 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 4419
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1918 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1975
Query: 4420 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 4479
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1976 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 2031
Query: 4480 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4539
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 2032 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 2087
Query: 4540 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4596
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 2088 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2139
Query: 4597 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4653
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2140 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2199
Query: 4654 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4713
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2200 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2258
Query: 4714 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2259 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2318
Query: 4773 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4823
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2319 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2370
Query: 4824 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4880
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2371 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2428
Query: 4881 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2429 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2488
Query: 4931 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4962
E N+++ K + + L S ++T +
Sbjct: 2489 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2548
Query: 4963 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 5022
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2549 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2608
Query: 5023 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 5082
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2609 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2668
Query: 5083 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 5136
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2669 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2728
Query: 5137 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 5196
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2729 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2788
Query: 5197 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 5256
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2789 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2848
Query: 5257 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 5295
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2849 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2908
Query: 5296 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 5355
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2909 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2962
Query: 5356 HKEFMKKVEEKRVDV 5370
++ ++KV+ R ++
Sbjct: 2963 LQDHLEKVKALRGEI 2977
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2834 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2890
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 269 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 328
Query: 2891 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2950
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 329 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 379
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 3007
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 380 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 437
Query: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 3065
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 438 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 495
Query: 3066 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 3125
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 496 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 542
Query: 3126 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 3185
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 543 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 587
Query: 3186 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 3245
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 588 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 639
Query: 3246 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 3304
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 640 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 697
Query: 3305 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 3364
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 698 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 732
Query: 3365 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 3419
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 733 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 792
Query: 3420 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 3479
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 793 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 851
Query: 3480 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3535
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 852 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 910
Query: 3536 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3590
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 911 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 961
Query: 3591 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3649
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 962 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 1021
Query: 3650 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3709
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 1022 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 1081
Query: 3710 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3769
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 1082 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1139
Query: 3770 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3826
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1140 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1196
Query: 3827 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3886
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1197 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1256
Query: 3887 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1257 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1313
Query: 3947 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 4006
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1314 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1370
Query: 4007 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 4065
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1371 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1428
Query: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1429 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1473
Query: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1474 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1533
Query: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1534 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1593
Query: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1594 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1642
Query: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 4362
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1643 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702
Query: 4363 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 4416
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1759
Query: 4417 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 4475
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1760 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1809
Query: 4476 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4535
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1810 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1856
Query: 4536 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4595
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1857 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1915
Query: 4596 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4650
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1916 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1975
Query: 4651 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4700
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1976 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 2030
Query: 4701 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4760
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 2031 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 2089
Query: 4761 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 2090 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2146
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2147 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2206
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2207 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2265
Query: 4940 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4998
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2266 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2325
Query: 4999 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 5051
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2326 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2379
Query: 5052 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 5081
L +K +K L + S W+ V +
Sbjct: 2380 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2437
Query: 5082 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2438 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2497
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2498 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2557
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2558 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2617
Query: 5251 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 5309
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2618 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2677
Query: 5310 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 5367
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2678 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2734
Query: 5368 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2735 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2794
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2795 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2852
Query: 5480 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5537
+ +E E+ G K +P PP + + + +++
Sbjct: 2853 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2904
Query: 5538 ARWQQVWLLALERQRKLNDALDRLEELKE 5566
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2905 TEWEKLNLHSADWQRKIDETLERLQELQE 2933
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 335 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 392
Query: 2498 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2557
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 393 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 450
Query: 2558 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 451 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 510
Query: 2616 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2671
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 511 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 570
Query: 2672 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2731
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 571 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 630
Query: 2732 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2778
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 631 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 688
Query: 2779 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2828
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 689 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 748
Query: 2829 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2879
+L ++ A + Q + S V V + K +E +N
Sbjct: 749 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 802
Query: 2880 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 803 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 853
Query: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2990
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 854 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 907
Query: 2991 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 3048
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967
Query: 3049 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 3107
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 968 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1024
Query: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 3167
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 1025 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1084
Query: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 3223
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 1085 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1135
Query: 3224 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 3279
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1136 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1195
Query: 3280 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 3339
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1196 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1254
Query: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 3398
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1255 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1314
Query: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1315 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1370
Query: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1371 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1426
Query: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3578
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1427 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1473
Query: 3579 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1474 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1533
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3698
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1534 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1593
Query: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3758
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1594 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1650
Query: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3816
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1651 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1710
Query: 3817 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3872
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1711 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1763
Query: 3873 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3930
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1764 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1800
Query: 3931 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3988
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1801 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1860
Query: 3989 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 4041
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1861 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1915
Query: 4042 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 4096
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1916 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1972
Query: 4097 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 4151
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1973 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2032
Query: 4152 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 2033 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2092
Query: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 4270
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 2093 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2149
Query: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2150 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2209
Query: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2210 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2268
Query: 4391 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2269 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2325
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2326 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2379
Query: 4508 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2380 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2427
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
SP +++ Q V ET K E
Sbjct: 2428 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2452
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
+ S+ A + N+ W E + DWL + + +
Sbjct: 2453 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2491
Query: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2492 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2551
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2552 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2611
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2612 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2671
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4920
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2672 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2731
Query: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2732 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2791
Query: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2792 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2851
Query: 5041 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 5080
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2852 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2911
Query: 5081 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2912 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2968
Query: 5141 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 5198
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2969 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3028
Query: 5199 KLEEA 5203
+L EA
Sbjct: 3029 QLHEA 3033
Score = 244 bits (622), Expect = 2e-63
Identities = 502/2853 (17%), Positives = 1100/2853 (38%), Gaps = 303/2853 (10%)
Query: 2296 EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355
+ + +SL +SE L + QT +E+ SWL +E L+ + + E +
Sbjct: 320 KSFGSSLMESEVNLDRYQTALEEVL----------SWLLSAEDTLQAQGEISNDVEVVKD 369
Query: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415
+ D+ +H+G + + G K++ GK + V++++ R+
Sbjct: 370 QFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQEQMNLLNSRW 423
Query: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475
L S+L+ +L L W+ E K+ + + D L+ Q
Sbjct: 424 ECLRVASMEKQSNLHRVLMDLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 481
Query: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ----------------- 2518
+ K LQE+L + QV V L + + E G+ A Q
Sbjct: 482 VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 541
Query: 2519 --ETTDSILSHFQSL-------SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569
IL +Q L S L+E+ + K Q + S LQ + ++ +
Sbjct: 542 RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 601
Query: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2629
LE K+ S +++ L + +K K + ++ L+ ++ + +TA + Q
Sbjct: 602 LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 661
Query: 2630 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ----P 2685
+ ++ ++ +++L +H +L K R + ++
Sbjct: 662 TTTQPSLTQTTVMETVTTVTTREQIL-----VKHAQEELPPPPPQKKRQITVDSEIRKRL 716
Query: 2686 DQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL--DLCQHQDRVQNLRKDF 2743
D DIT I ++ + + E ++L A+ + + ++Q+ +
Sbjct: 717 DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 776
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEH 2803
L + + +A S ++ ++ F + L E + ++ +Q+E
Sbjct: 777 QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 836
Query: 2804 LKSLLDDWAS-KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS-SVGSVNGY 2861
+ + ++W + T E + L+ D + + P + + S+
Sbjct: 837 MTTTAENWLKIQPTTPSEPTAIKSQLK------ICKDEVNRLSGLQPQIERLKIQSIALK 890
Query: 2862 HTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV-HKEANSVLQ-WLESK 2919
+ + D ++++ + R++ LQ I + + + ++E S ++ W++
Sbjct: 891 EKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS 950
Query: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEA 2979
E L S T E ++ + +A + L++ + + + + P S+ +
Sbjct: 951 ETKLSI--PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1007
Query: 2980 ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
++ EE+ RW++ + V ++LEE + L Q L+ W+ E ++ +
Sbjct: 1008 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1067
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
P D +L Q +Q + ++ + + + +NE Q I S+++ EL+
Sbjct: 1068 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKE 1125
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N +W + ++ +R + + K+ Q+ L ++ E + + + P+ +
Sbjct: 1126 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1185
Query: 3160 KQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE--QYLKDELKKRLETVALPLQGL 3217
++ +EE + + +Q + +VK L + ++ +I + ++ LKK LET+ Q L
Sbjct: 1186 QKAVEEMKRAKEEAQQKEAKVK---LLTESVNSVIAQAPPVAQEALKKELETLTTNYQWL 1242
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ L+ A + ++ WL++ + + I E + L E
Sbjct: 1243 CTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLE 1302
Query: 3278 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 3337
+ + ++ G + +L + W EL ++ RQ
Sbjct: 1303 NLMRHSEDNPNQIRILAQ------TLTDGGVMDELINEELETFNSRWRELHEEAVRRQKL 1356
Query: 3338 LKDCMQKAQKYQWHV-----------EDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSK 3386
L+ +Q AQ+ + + + L +I D K+ ++ + +++S L +
Sbjct: 1357 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD---KVDAAQMPQEAQKIQSDLTSHE 1413
Query: 3387 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRD--EKAGINQNMDAVTEELQAKTGS 3444
L E++K E AA +++ + + ++D K + Q + LQ
Sbjct: 1414 ISLEEMKKHNQGKE----AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1469
Query: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504
L+E+ L + K++E++V Q+ N + ++ EV +E
Sbjct: 1470 LDEVKMHLPALET--KSVEQEV--------------VQSQLNHCVNLYKSLSEVKSEVEM 1513
Query: 3505 QVDYLRNFTQGLVEDAPDGSD---ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
+ R Q + P D + LH E+ + E KQ++ C+ + K+
Sbjct: 1514 VIKTGRQIVQKKQTENPKELDERVTALKLHYNELG-AKVTERKQQLEK-CLKLSRKMRK- 1570
Query: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI-----EDVRLFLNKIHVLKLDI 3616
+ + LA D EL A+ +L S++ + K+H LK
Sbjct: 1571 -----EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH-LKSIT 1624
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL---GRVEDF 3673
E EA + +L ++ TL ++ +L LN +T R +E L L L +E F
Sbjct: 1625 EVGEA-LKTVLGKKETL----VEDKLSLLNSNWIAVTSRA---EEWLNLLLEYQKHMETF 1676
Query: 3674 YRKL----KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3729
+ + K + A T +E+E + QQ D K +++ ++ K+
Sbjct: 1677 DQNVDHITKWIIQADTLLDESEKKK----------PQQKEDVLKRLKAELNDIRPKVDST 1726
Query: 3730 NGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
L+ + G C + +E + E+N R+ ++ ++ GK L+
Sbjct: 1727 RDQAANLMANRGDHCR-KLVEPQISELNHRFAAISHRI------------KTGKASIPLK 1773
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
L + +D ++L+ +P AE + ++E+ + + +D + TV L G + Q
Sbjct: 1774 ELEQFNSDIQKLL---EPLEAEIQ-QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1829
Query: 3850 -AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908
+ RE+I + + L+++ L + R+K+ +I Q+ A+ + L E
Sbjct: 1830 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1889
Query: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
KKLA S P KI++ + L++ E QA + + +++ Q LS
Sbjct: 1890 KKLA-SLPEPRDERKIKE---IDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS 1945
Query: 3969 EKIDSLQARYSEI------QDRCCRKAALL----DQALSNARL---FGEDEVEVLNWLAE 4015
++ +++++++ Q R+ ++ D L + + + + V L E
Sbjct: 1946 KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE 2005
Query: 4016 VEDKLSS--VFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
VE L++ + KDF+ L +Q + + + +D A L+ T E
Sbjct: 2006 VEQLLNAPDLCAKDFED--LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2063
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
+ +QE L + ++ + +++ + +F + WL E E+ L +
Sbjct: 2064 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT- 2122
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
Q P + +++ KEL+ + + + V+ T+N +++ L + + N
Sbjct: 2123 -QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLN 2181
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLE---QDQ 4250
+++ V + R ++ ++++ + + W+ E + I LE + Q
Sbjct: 2182 LRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN----IASIPLEPGKEQQ 2237
Query: 4251 TTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAI 4308
+L+ K ++ + + +L + E++ L+ K + Q+ +
Sbjct: 2238 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKV 2297
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE-EM 4367
S E+ +E + Q + E+L + ++ + + + Q Q+ ++
Sbjct: 2298 SRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 2357
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK---EEVRQR- 4423
++ ++ +P ++++L G L + P + V+ K + + + + +E+R +
Sbjct: 2358 QETEIAVQAKQPDVEEILSKGQHLYKEKPAT-QPVKRKLEDLSSEWKAVNRLLQELRAKQ 2416
Query: 4424 ------------------ALALDEAVSQSTQITEFHDKIEPMLET--------------- 4450
L V++ T I++ MLE
Sbjct: 2417 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2476
Query: 4451 -LENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4509
L L ++ ++ +++ I E I K+ +LE+ +P E L + L ++
Sbjct: 2477 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2536
Query: 4510 DKDLAAKEIQDKLDQMVFFWEDIKARAEER----------EIKFLDVLELAEKFWYDMAA 4559
+ A I D+++++ W++++ + R ++L+ E AE+ A
Sbjct: 2537 E---ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2593
Query: 4560 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4619
L + K+ V ++ + + + + +T + + L L+ +R AD
Sbjct: 2594 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD----- 2646
Query: 4620 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD----- 4674
+T K V + +N +W +++K ER LE+ + Q+ L+ WL
Sbjct: 2647 -DTRK--VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2703
Query: 4675 -NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4733
N + + D VK+ + + ++ + E+ L+ + +L+ D
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2763
Query: 4734 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4793
+++ L + W L +K + + LE + + +L+EL+ WL ++ L Q
Sbjct: 2764 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2823
Query: 4794 RPISGDPKVIEVELAKHHVLKNDVLAHQ----ATVETVN-------KAGNELL------- 4835
PI GD ++ + H K ++ + +T+ETV G E L
Sbjct: 2824 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2883
Query: 4836 --ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELT 4893
E A + LR + E +N WE + + + ++++ TL++ Q ++ L+L
Sbjct: 2884 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2943
Query: 4894 RMESQLSASKPTGG-LPETAREQLDTHMELYSQLKAKEETYNQLLDKGR-LMLLSRDDSG 4951
+ E + +P G L ++ ++ L+ L ++ +E + + D R L L S
Sbjct: 2944 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3003
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
T + L +W ++ +E+R +L EA
Sbjct: 3004 YNLSTLED---LNTRWKLLQVAVEDRVRQLHEA 3033
Score = 226 bits (575), Expect = 7e-58
Identities = 493/2775 (17%), Positives = 1066/2775 (38%), Gaps = 371/2775 (13%)
Query: 1952 SEIDVDSLNLCLQQY-------EDLKQPMAERKAQLDALAFDIQFFISE-HAQDLSPQQN 2003
SE+++D L++ ED Q E ++ + QF E + DL+ Q
Sbjct: 329 SEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD--QFHTHEGYMMDLTAHQG 386
Query: 2004 R--QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC------- 2054
R +L+L ++L + + + E +V L + V +++KQ N
Sbjct: 387 RVGNILQLGSKLIGTGK-LSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 445
Query: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSF 2108
+Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 446 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 505
Query: 2109 ATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVAQK 2157
VV + G +EE L R R L +++ L EE +
Sbjct: 506 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 565
Query: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 566 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLLST 622
Query: 2218 SLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 2276
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 623 LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT---- 678
Query: 2277 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWLER 2335
+T EQ +++ E L + K+ T+ E++K L D E SW+ R
Sbjct: 679 -TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWITR 729
Query: 2336 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 2395
SE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 730 SEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 780
Query: 2396 EPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWMQA 2452
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 781 EQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTT 840
Query: 2453 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2512
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 841 AENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ--- 894
Query: 2513 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQNL 2570
+ + +HF+ + + R LQ QE++ ++ + + E L
Sbjct: 895 GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 954
Query: 2571 EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKL 2630
Q+S ++++ L L+ + Q+S L V + A S + Q +
Sbjct: 955 SIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEF 1014
Query: 2631 AEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2683
E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 1015 EEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD-- 1072
Query: 2684 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDF 2743
+ + +Q + L +++ Q +L+++ ++ + + + ++ L +
Sbjct: 1073 --SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1130
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIE 2802
+ + V R++ E+ +K + +W+ + E + + EL+K +E
Sbjct: 1131 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1190
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+K ++ K V+ + T N ++ P +Q
Sbjct: 1191 EMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ--------------------- 1225
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1226 -----EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1280
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQEAE 2980
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1281 LKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE--- 1335
Query: 2981 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 3040
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1336 -----LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA 1390
Query: 3041 LSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 3097
+D + + Q++Q L E ++H Q EAAQ +L+ QK+L
Sbjct: 1391 DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQKKL 1443
Query: 3098 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE 3157
Q ++ K+ + K +++ LQ+ + V L S + E
Sbjct: 1444 QDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQE 1488
Query: 3158 AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLETV 3210
V+ QL + L ++ EV E+ + G Q ++ EL +R+ +
Sbjct: 1489 VVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVTAL 1540
Query: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
L L +R +L+ L +++ ++ + L WL + K + L
Sbjct: 1541 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1600
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
S++ + QK + + + I GE+L + G+++ ++++L L ++W ++ +
Sbjct: 1601 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVTSR 1658
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
+ + L + + + + +V+ + WI + E P Q E L R KA LN
Sbjct: 1659 AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELN 1717
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LEEM 3448
++ R + + AA+++ N + + + + +N A++ ++ S L+E+
Sbjct: 1718 DI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL 1775
Query: 3449 TQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSNKN 3488
Q + Q+ + +E +++ K L+ D L + +
Sbjct: 1776 EQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1835
Query: 3489 LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3548
E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ + ++
Sbjct: 1836 REEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKCLD 1886
Query: 3549 SGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDVRL 3604
+E KL + + +++E+ +L +EL+ + A G D +E ++
Sbjct: 1887 D----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI 1942
Query: 3605 FLNK-------------------IHVLK----------LDIEASE------AECRH---- 3625
L+K IH ++ + +E S E H
Sbjct: 1943 QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQA 2002
Query: 3626 MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K +
Sbjct: 2003 LLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2058
Query: 3685 TAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFKMF 3714
T E EAL QW +++I NQ L + + F
Sbjct: 2059 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2118
Query: 3715 QKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753
++ P Q ++ +N G+ +IQ + K D L+ +
Sbjct: 2119 LRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQEKL 2177
Query: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3813
+N RW + K+++ R +L+E +FQ L + WL + + + + P E +
Sbjct: 2178 GSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQ 2237
Query: 3814 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRWTE 3871
+K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W +
Sbjct: 2238 -LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2296
Query: 3872 ----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQTAK 3923
L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2297 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2356
Query: 3924 IQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------AEQ 3964
+Q+ I +A + D+E + K + + L L+S A+Q
Sbjct: 2357 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2416
Query: 3965 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEVLN 4011
L+ + ++ A ++ + + A+S + F E+ +
Sbjct: 2417 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2476
Query: 4012 WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE 4071
WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+ +
Sbjct: 2477 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2536
Query: 4072 EV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 4130
E +I ++++ I+ ++ ++ + L + + +T++ EE L + +L
Sbjct: 2537 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2596
Query: 4131 TSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 4190
+ T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2597 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 2656
Query: 4191 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----- 4245
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2657 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2716
Query: 4246 LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESLIQ 4303
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2717 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2776
Query: 4304 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 4363
++ + + + LE + + + +EL W++ +++ D +++Q
Sbjct: 2777 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2836
Query: 4364 QEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAENMY 4413
+ R + + +P I L+ L++L E E+ EE+ Q +
Sbjct: 2837 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2896
Query: 4414 AQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 4472
+ EEV L+ + +I E ++++ + E + L +LR +I +
Sbjct: 2897 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2956
Query: 4473 ECISDNKSATVELEK 4487
+ + D+ +E K
Sbjct: 2957 DLLIDSLQDHLEKVK 2971
Score = 204 bits (518), Expect = 3e-51
Identities = 414/2141 (19%), Positives = 854/2141 (39%), Gaps = 303/2141 (14%)
Query: 1804 LEHDEKLVSYLSLLRNIEMRTKQIQP----LELNLAELQDLLCQAKVLERELKDLTTLVS 1859
+EH +KL ++ LR I+ + ++ +++ L E L +++L+++LK LVS
Sbjct: 1029 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVS 1088
Query: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK 1919
+++ + + S + +A + A L+ L ++ W+ H V K
Sbjct: 1089 -DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD----HMCQQVYARKEA 1143
Query: 1920 V---LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER 1976
+ L + L+ L ++ W+ + + D L +++ + K+ ++
Sbjct: 1144 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQK 1202
Query: 1977 KAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQ 2036
+A++ L + I++ P + + L L ++Q + + +
Sbjct: 1203 EAKVKLLTESVNSVIAQ----APPVAQEALKKELETLTTNYQWLCTRLNGK--------- 1249
Query: 2037 QMEQEALVKTLQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQ------QDLSAL 2087
KTL++ H+ LE W+ + E L +TT+ +++S +
Sbjct: 1250 -------CKTLEEVWACWHELLSYLEKANKWLNEVEFKL-----KTTENIPGGAEEISEV 1297
Query: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
+ +L +D N+ A + D G M+E + E+L ++
Sbjct: 1298 LDSLENLMRHSEDNPNQIRILAQTLTD-GGVMDE-----------LINEELETFNSRWRE 1345
Query: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 2207
L EE QK LE+++ SA QETEKS + E+ ID L + Q+
Sbjct: 1346 LHEEAVRRQKLLEQSIQSA--QETEKS--LHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1401
Query: 2208 LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE------LLSQQQNF 2261
++ S + + +L+ + +A +++ Q ++ + + Q+ L + NF
Sbjct: 1402 AQKIQ--SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF 1459
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ---------- 2311
Q ++ LD+ +L E + ++Q++ + + + +L +S +E+K
Sbjct: 1460 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1519
Query: 2312 --VQTLQDELQKFLQD---------------------------------HKEFE---SWL 2333
VQ Q E K L + KE WL
Sbjct: 1520 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1579
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
++ EL P L S + + +++ K L+ +T G+ + +
Sbjct: 1580 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----L 1634
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWM 2450
GK+ + LV+DKL + A+ S R LN+LL Q H F + D + W+
Sbjct: 1635 GKKET----LVEDKLSLLNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI 1687
Query: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2510
+ LL ++ P Q++ K+L+ EL + + V+ + A ++M G
Sbjct: 1688 ----IQADTLLDESEKKKP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-- 1738
Query: 2511 APDH-RHVQETTDSILSH-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSI 2563
DH R + E S L+H F ++S+ + ++S+ K + Q Q + E LE+ +Q
Sbjct: 1739 --DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1796
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTT 2622
+++ K ++ + G ++E L L+Q I ++ E ++ + + A
Sbjct: 1797 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1856
Query: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2682
+ + K E+S ++ Q ++ + L + +++ + LAS
Sbjct: 1857 RSQRRKKALEISHQWYQ---------------------YKRQADDLLKCLDDIEKKLASL 1895
Query: 2683 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
+P + ++I+E++ E++ ++E L+ + LS G A+ + +
Sbjct: 1896 PEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV------------E 1938
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
T++Q + + RE ++ Q + F + + T ++ P E S +I
Sbjct: 1939 PTQIQLSKRWREIESKFAQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEIT 1997
Query: 2803 HLKSLL---------DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS 2853
H+ L D +K E++ + SL+N+ DS ++ + + S
Sbjct: 1998 HVSQALLEVEQLLNAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHS 2049
Query: 2854 SVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVL 2913
+ T + ++Q +S ++ ++EK+ + +RQ + + H +
Sbjct: 2050 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 2109
Query: 2914 QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---L 2970
QWL E+ L+ P E K K +L EL+ + Q V L +
Sbjct: 2110 QWLTEAEQFLRKTQI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEI 2161
Query: 2971 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 3030
+ + +A ++ LN RW+ + R+++LEE + L+ FQ ++ WL E
Sbjct: 2162 IQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE 2221
Query: 3031 KELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
+ + + PL L + +QV+ +++E R+ +QLNE +L
Sbjct: 2222 ADNIASI--PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE 2279
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV- 3148
+++ +L+ N +W++++ L + +I+ I Q ++ L+DL E++ + LS
Sbjct: 2280 QDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2339
Query: 3149 --QSAISTQPE------------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLI 3194
Q I QP AV+ + + EI S + L E Q + +L L
Sbjct: 2340 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2399
Query: 3195 GEQYLKDELKKRL-------------------ETVALPLQGL--EDLAADRI---NRLQA 3230
E + L + L +TV L Q + ++ A ++ + L
Sbjct: 2400 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLML 2459
Query: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
+ + F + + EL WL + LE + + + + + L Q
Sbjct: 2460 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 2519
Query: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
E ++ ++L E + + +++ ++N W+E+ + +R+ +L + ++ + ++
Sbjct: 2520 EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 2579
Query: 3351 HVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407
E+ + +AK+ + T+D +Q + +K + ++ + ++ +++ N A
Sbjct: 2580 AKEEAEQVLGQARAKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLAL 2637
Query: 3408 ILINSSEADED-GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIE 3463
L+ AD+ + IN + ++ + + + +LEE + L++F E F
Sbjct: 2638 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 2697
Query: 3464 KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVED 3519
+ E + L+ +K +++L Q + LQ +E D N +Q ++
Sbjct: 2698 TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS 2757
Query: 3520 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3579
DA L + + ++ E++++ + +E + + H ++E+ L D
Sbjct: 2758 LEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2817
Query: 3580 DELDGMGAIGRDTDSLQSQ---------------------IEDVRLFLNKIHVLKLDIEA 3618
DEL IG D ++Q Q +E VR+FL + + L E
Sbjct: 2818 DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EK 2875
Query: 3619 SEAECRHMLEEEGTLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKL 3677
E R + EE ++ L+++ E +N + KL Q +++ TL R+++
Sbjct: 2876 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2935
Query: 3678 KGLNDATTAAEEAEALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
L+ AE + VG ++ + L K + E + PL+ + VN L + L
Sbjct: 2936 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL 2994
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777
+ G L +E++N RW L V R+ QL EA
Sbjct: 2995 -TTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHEA 3033
Score = 194 bits (492), Expect = 3e-48
Identities = 469/2759 (16%), Positives = 1097/2759 (39%), Gaps = 318/2759 (11%)
Query: 1807 DEKLVSYLSLLRNIEMRTKQIQ--PLELNLAELQDLLCQAKVLERELKDLTTLVSQELEC 1864
++KL L E RT++++ PL +L +L+ + Q KVL+ +L+ V+
Sbjct: 446 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 505
Query: 1865 VNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQH 1924
V + S A ALE+ K L +++ R + Q+ +L +
Sbjct: 506 VVVVDESSGDHATA----ALEEQLKVLGDRWANICRWTEDRWVLLQD--------ILLKW 553
Query: 1925 TQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA 1984
+L AW+ K +N + D + + LQ+ LK + ++K + L
Sbjct: 554 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 613
Query: 1985 FDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV 2044
Q +S Q+ L + LE++ AQ+ +A+
Sbjct: 614 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS-----------QAVT 662
Query: 2045 KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 2104
T Q + + + + V E+ L H Q++L + + +I+ R
Sbjct: 663 TT---QPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDSEIRKR 715
Query: 2105 A----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQEETRV 2154
T + + E ++ + + +E + L+EK++ + E++ LQ+ +R
Sbjct: 716 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 775
Query: 2155 AQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLLTNLPG 2210
AQ +E+ V + ++ K +A+++L E + + L+W+ + L
Sbjct: 776 AQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQ 833
Query: 2211 MEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270
+EQ++ + + T P + Q ++ K L Q I +
Sbjct: 834 LEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERLKIQSI 887
Query: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKE 2328
L + G L + + +A K++QT+ D L ++ +
Sbjct: 888 ALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSA 942
Query: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
+W+++SE +L + E + L + + + L +++ + +++
Sbjct: 943 IRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM---- 998
Query: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
K PSEI + + ++ R+ L S+ L + + + QN +L+
Sbjct: 999 ----SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 1054
Query: 2449 WMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
WM A V+ L + D +L++QL KQ + +++ Q L V +I
Sbjct: 1055 WM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNEGGQKI 1107
Query: 2507 EGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2565
+ E P+ ET + + + + + R L+ + ++ S+Q+ L + + + +
Sbjct: 1108 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1167
Query: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1168 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1227
Query: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRMLASGNQ 2684
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++ + N
Sbjct: 1228 LKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENI 1287
Query: 2685 PD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1288 PGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LETFNSR 1342
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
+ EL + R+K L+ + +ETE S+ + S++ ++KQ+
Sbjct: 1343 WRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--IDKQLA 1386
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+ D A ++I TS E + +E +QGK +
Sbjct: 1387 AYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA--------------QR 1431
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
+ Q + DV++K+ L ++ + + L + + E L LE+K
Sbjct: 1432 VLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALETKS-- 1484
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2982
+ E V++Q L + +++ V + ++ ++ EN
Sbjct: 1485 ----------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKKQTENP 1530
Query: 2983 KKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
K++ E + + E+ R++QLE+ + + L WL ++ +
Sbjct: 1531 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1590
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
+ P+ L+++ + KE E ++ + + E + + T G + V+ +L
Sbjct: 1591 AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVEDKLSL 1647
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N W+ +T S+ ++ + +YQ+ ++ + V + + + + + E
Sbjct: 1648 LNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKK 1700
Query: 3160 KQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217
K Q +E ++++L + +V + L G D +K +E L
Sbjct: 1701 KPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQISELNHR 1755
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ RI +A++ ++ +Q +++ L+ P+ A+++ Q + E
Sbjct: 1756 FAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGVNLKEE 1802
Query: 3278 EFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 3336
+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L + R+
Sbjct: 1803 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1862
Query: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVE 3393
+ + + +Y+ +DL+ ++D + K++ L D +++ L + K LN V
Sbjct: 1863 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1922
Query: 3394 KRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL--EEMT 3449
++ L +A + + + I + A + A ++ +T + E+M
Sbjct: 1923 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1982
Query: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP----- 3504
+ ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1983 LEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQS 2040
Query: 3505 --QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEG 3560
++D + + ++ A + ++ Q ++Q +F +V + + +E
Sbjct: 2041 SGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEK 2097
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEA 3618
+FH ++ +F+Q ++ I + + + + +++++ + + + + A
Sbjct: 2098 WRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2156
Query: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGRVEDFY 3674
+ E ++++ D L+ +L +LN + C +L++R K +EQ + + +F
Sbjct: 2157 TGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQ 2209
Query: 3675 RKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVN 3730
R L N+ EEA+ + + G E ++ ++L K+ +E PL+ L+Q+N
Sbjct: 2210 RDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLN 2263
Query: 3731 GLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+ + LE
Sbjct: 2264 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2323
Query: 3790 PL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
L L WL+ + P+ E +QE ++ + ++ V+ + ++
Sbjct: 2324 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVEEILSK 2377
Query: 3843 GGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------------ 3887
G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2378 GQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2435
Query: 3888 -----VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEPVGTQT 3921
V+ K+ F+ ++D+LS+ ++ + + +
Sbjct: 2436 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2495
Query: 3922 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSE 3980
I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q ++ E
Sbjct: 2496 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2555
Query: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADH 4040
+Q+ + L++ L ++ + E + E L + KL S + D + ++ +
Sbjct: 2556 VQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITET 2615
Query: 4041 LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 4100
L +++ + NVD A LL+ + ++ + + I + I S+
Sbjct: 2616 KQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAA 2675
Query: 4101 LEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQKELKK 4154
LE+ +L +F E+ WL E E ++ + + + ++ ++L+
Sbjct: 2676 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2735
Query: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTIGQRVD 4208
E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2736 EIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2790
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF------- 4261
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2791 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2850
Query: 4262 ------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAI 4308
+++ +R + +++L+ E+ + T +L+++ E + ++E +
Sbjct: 2851 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2910
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEM 4367
+L +++ +++ + + E +EL + + + P + + L+ E++
Sbjct: 2911 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2970
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
+ LR IA K ++ + + QL +L+P +E+ + + + +++ VRQ
Sbjct: 2971 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3029
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3831
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 324 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 383
Query: 3832 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3889
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 384 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 441
Query: 3890 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 442 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 501
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
+ + + L E++ L R++ I + LL L + E++
Sbjct: 502 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 561
Query: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 4066
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 562 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 621
Query: 4067 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 4113
+ V E D + + T S+A+ T + + T ++
Sbjct: 622 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 681
Query: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 4172
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 682 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 735
Query: 4173 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 4215
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 736 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 795
Query: 4216 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 4259
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 796 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 855
Query: 4260 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 4312
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 856 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 913
Query: 4313 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 914 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 973
Query: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 4426
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 974 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1023
Query: 4427 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 4472
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 1024 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1077
Query: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 1078 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1133
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1134 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1193
Query: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1194 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1253
Query: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4708
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1254 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1313
Query: 4709 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4768
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1314 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1363
Query: 4769 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1364 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1420
Query: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1421 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1466
Query: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4948
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1467 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1525
Query: 4949 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 5008
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1526 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1585
Query: 5009 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 5068
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1586 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1644
Query: 5069 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 5099
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1645 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1704
Query: 5100 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 5129
+ K+L L D +DS + ++N D
Sbjct: 1705 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1764
Query: 5130 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1765 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1824
Query: 5188 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 5233
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1825 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1883
Query: 5234 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 5287
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1884 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1941
Query: 5288 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 5347
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1942 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 1998
Query: 5348 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 1999 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2058
Query: 5396 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 5444
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 2059 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2118
Query: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5504
L + IP+N + K ++ +++E+ V +T
Sbjct: 2119 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2155
Query: 5505 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5564
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2156 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2208
Query: 5565 KEFANFDFDVW 5575
+ N +F +W
Sbjct: 2209 QRDLN-EFVLW 2218
Score = 91.3 bits (225), Expect = 3e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 5087 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 5146
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 323 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 382
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 383 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 442
Query: 5206 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 5263
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 443 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 500
Query: 5264 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 5322
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 501 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 560
Query: 5323 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 5380
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 561 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 619
Query: 5381 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 5437
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 620 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 679
Query: 5438 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 5494
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 680 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 733
Query: 5495 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5554
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 734 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 789
Query: 5555 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5614
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 790 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 845
Query: 5615 LASKFPTTKLEMTAV 5629
PTT E TA+
Sbjct: 846 --KIQPTTPSEPTAI 858
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 261 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 320
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2832
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 321 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 372
Query: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2892
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 373 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 428
Query: 2893 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2950
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 429 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 488
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2991
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 489 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 548
Query: 2992 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 3024
T+ TV ++RQ+ + ++L
Sbjct: 549 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 608
Query: 3025 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 3083
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 609 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 668
Query: 3084 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 669 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 727
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 3202
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 728 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 766
Query: 3203 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 3241
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 767 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 824
Query: 3242 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 3300
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 825 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 882
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 883 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 942
Query: 3361 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 3418
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 943 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1002
Query: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 3477
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1003 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1062
Query: 3478 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1063 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1121
Query: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1122 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1174
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3654
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1175 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1233
Query: 3655 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3714
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1234 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1273
Query: 3715 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3772
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1274 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1320
Query: 3773 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1441 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1500
Query: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1501 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1559
Query: 4001 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 4058
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1560 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1612
Query: 4059 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 4116
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1613 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1672
Query: 4117 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 4167
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1673 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1732
Query: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 4222
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1733 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1790
Query: 4223 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1791 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1842
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
F Q ++E+T ++ + + + + + + +S
Sbjct: 1843 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 1887
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 4398
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 1888 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 1947
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 4458
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 1948 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2004
Query: 4459 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4516
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2005 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2057
Query: 4517 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4576
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2058 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2116
Query: 4577 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4634
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2117 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2175
Query: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4694
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2176 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2232
Query: 4695 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4739
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2233 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2292
Query: 4740 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4772
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2293 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2352
Query: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2353 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2412
Query: 4833 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2413 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2472
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2473 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2531
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2532 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2591
Query: 5012 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 5064
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2592 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2651
Query: 5065 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2652 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2711
Query: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 5170
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2712 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2771
Query: 5171 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 5225
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2772 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2831
Query: 5226 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 5283
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2832 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 2890
Query: 5284 KGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
L++L+TRW L V+ + R+ Q
Sbjct: 2891 LSTLEDLNTRWKL---LQVAVEDRVRQ 2914
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2772 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2828
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 205 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 259
Query: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2888
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 260 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 315
Query: 2889 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2948
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 316 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 373
Query: 2949 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2998
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 374 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 433
Query: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 3057
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 434 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 482
Query: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 3117
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 483 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 541
Query: 3118 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 3171
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 542 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600
Query: 3172 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 3213
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 601 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660
Query: 3214 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 3258
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 661 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720
Query: 3259 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 721 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 777
Query: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 3364
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 778 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 837
Query: 3365 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 3421
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 838 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 896
Query: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 3480
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 897 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 956
Query: 3481 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3540
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 957 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1015
Query: 3541 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3600
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1016 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1075
Query: 3601 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3660
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1076 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1135
Query: 3661 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
+ LE + L+ N E + E I++ L + + D
Sbjct: 1136 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1195
Query: 3721 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1196 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1246
Query: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3839
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1247 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1304
Query: 3840 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3897
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1305 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1344
Query: 3898 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1345 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1404
Query: 3954 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 4013
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464
Query: 4014 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1465 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1523
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1524 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1583
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1584 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1638
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 4253
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1639 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1692
Query: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1693 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1743
Query: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 4373
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1744 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1802
Query: 4374 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 4419
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1803 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 4420 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 4479
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 1916
Query: 4480 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4539
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 1972
Query: 4540 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4596
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 1973 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2024
Query: 4597 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4653
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2025 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2084
Query: 4654 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4713
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2085 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2143
Query: 4714 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2144 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2203
Query: 4773 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4823
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2204 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2255
Query: 4824 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4880
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2256 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2313
Query: 4881 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2314 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2373
Query: 4931 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4962
E N+++ K + + L S ++T +
Sbjct: 2374 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2433
Query: 4963 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 5022
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2434 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2493
Query: 5023 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 5082
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2494 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2553
Query: 5083 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 5136
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2554 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2613
Query: 5137 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 5196
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2614 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2673
Query: 5197 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 5256
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2674 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2733
Query: 5257 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 5295
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2734 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2793
Query: 5296 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 5355
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2794 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2847
Query: 5356 HKEFMKKVEEKRVDV 5370
++ ++KV+ R ++
Sbjct: 2848 LQDHLEKVKALRGEI 2862
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2834 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2890
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 154 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 213
Query: 2891 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2950
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 214 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 264
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 3007
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 265 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 322
Query: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 3065
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 323 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 380
Query: 3066 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 3125
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 381 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 427
Query: 3126 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 3185
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 428 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 472
Query: 3186 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 3245
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 473 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 524
Query: 3246 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 3304
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 525 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 582
Query: 3305 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 3364
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 583 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 617
Query: 3365 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 3419
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 618 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 677
Query: 3420 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 3479
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 678 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 736
Query: 3480 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3535
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 737 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 795
Query: 3536 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3590
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 796 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 846
Query: 3591 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3649
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 847 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 906
Query: 3650 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3709
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 907 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 966
Query: 3710 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3769
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 967 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1024
Query: 3770 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3826
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1025 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1081
Query: 3827 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3886
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1082 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1141
Query: 3887 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1142 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1198
Query: 3947 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 4006
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1199 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1255
Query: 4007 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 4065
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1256 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1313
Query: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1314 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1358
Query: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1479 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1527
Query: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 4362
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1528 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587
Query: 4363 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 4416
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1588 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1644
Query: 4417 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 4475
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1645 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1694
Query: 4476 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4535
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1695 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 4536 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4595
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1742 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1800
Query: 4596 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4650
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1801 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 4651 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4700
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 1915
Query: 4701 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4760
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 1916 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 1974
Query: 4761 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 1975 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2031
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2032 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2091
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2092 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2150
Query: 4940 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4998
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2151 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2210
Query: 4999 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 5051
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2211 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2264
Query: 5052 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 5081
L +K +K L + S W+ V +
Sbjct: 2265 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2322
Query: 5082 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2323 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2382
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2383 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2442
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2443 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2502
Query: 5251 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 5309
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2503 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562
Query: 5310 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 5367
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2563 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2619
Query: 5368 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2620 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2679
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2680 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2737
Query: 5480 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5537
+ +E E+ G K +P PP + + + +++
Sbjct: 2738 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2789
Query: 5538 ARWQQVWLLALERQRKLNDALDRLEELKE 5566
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2790 TEWEKLNLHSADWQRKIDETLERLQELQE 2818
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 220 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 277
Query: 2498 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2557
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 278 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 335
Query: 2558 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 336 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 395
Query: 2616 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2671
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 396 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 455
Query: 2672 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2731
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 456 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 515
Query: 2732 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2778
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 516 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 573
Query: 2779 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2828
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 574 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 633
Query: 2829 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2879
+L ++ A + Q + S V V + K +E +N
Sbjct: 634 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 687
Query: 2880 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 688 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 738
Query: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2990
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 792
Query: 2991 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 3048
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852
Query: 3049 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 3107
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 853 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 909
Query: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 3167
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 910 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 969
Query: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 3223
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 970 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020
Query: 3224 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 3279
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080
Query: 3280 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 3339
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1139
Query: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 3398
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1140 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1199
Query: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1200 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1255
Query: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1256 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1311
Query: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3578
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1312 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1358
Query: 3579 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3698
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3758
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1479 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1535
Query: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3816
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1536 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1595
Query: 3817 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3872
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1596 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1648
Query: 3873 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3930
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1649 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1685
Query: 3931 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3988
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1686 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1745
Query: 3989 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 4041
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1746 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1800
Query: 4042 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 4096
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1801 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857
Query: 4097 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 4151
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1858 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 1917
Query: 4152 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 1918 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 1977
Query: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 4270
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 1978 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2034
Query: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2035 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2094
Query: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2095 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2153
Query: 4391 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2154 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2210
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2211 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2264
Query: 4508 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2265 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2312
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
SP +++ Q V ET K E
Sbjct: 2313 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2337
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
+ S+ A + N+ W E + DWL + + +
Sbjct: 2338 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2376
Query: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2377 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2436
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2437 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2496
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2497 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2556
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4920
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2557 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2616
Query: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2617 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2676
Query: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2677 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2736
Query: 5041 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 5080
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2737 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2796
Query: 5081 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2797 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2853
Query: 5141 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 5198
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2854 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 2913
Query: 5199 KLEEA 5203
+L EA
Sbjct: 2914 QLHEA 2918
Score = 244 bits (622), Expect = 2e-63
Identities = 502/2853 (17%), Positives = 1100/2853 (38%), Gaps = 303/2853 (10%)
Query: 2296 EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355
+ + +SL +SE L + QT +E+ SWL +E L+ + + E +
Sbjct: 205 KSFGSSLMESEVNLDRYQTALEEVL----------SWLLSAEDTLQAQGEISNDVEVVKD 254
Query: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415
+ D+ +H+G + + G K++ GK + V++++ R+
Sbjct: 255 QFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQEQMNLLNSRW 308
Query: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475
L S+L+ +L L W+ E K+ + + D L+ Q
Sbjct: 309 ECLRVASMEKQSNLHRVLMDLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 366
Query: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ----------------- 2518
+ K LQE+L + QV V L + + E G+ A Q
Sbjct: 367 VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 426
Query: 2519 --ETTDSILSHFQSL-------SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569
IL +Q L S L+E+ + K Q + S LQ + ++ +
Sbjct: 427 RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 486
Query: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2629
LE K+ S +++ L + +K K + ++ L+ ++ + +TA + Q
Sbjct: 487 LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 546
Query: 2630 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ----P 2685
+ ++ ++ +++L +H +L K R + ++
Sbjct: 547 TTTQPSLTQTTVMETVTTVTTREQIL-----VKHAQEELPPPPPQKKRQITVDSEIRKRL 601
Query: 2686 DQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL--DLCQHQDRVQNLRKDF 2743
D DIT I ++ + + E ++L A+ + + ++Q+ +
Sbjct: 602 DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 661
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEH 2803
L + + +A S ++ ++ F + L E + ++ +Q+E
Sbjct: 662 QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 721
Query: 2804 LKSLLDDWAS-KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS-SVGSVNGY 2861
+ + ++W + T E + L+ D + + P + + S+
Sbjct: 722 MTTTAENWLKIQPTTPSEPTAIKSQLK------ICKDEVNRLSGLQPQIERLKIQSIALK 775
Query: 2862 HTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV-HKEANSVLQ-WLESK 2919
+ + D ++++ + R++ LQ I + + + ++E S ++ W++
Sbjct: 776 EKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS 835
Query: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEA 2979
E L S T E ++ + +A + L++ + + + + P S+ +
Sbjct: 836 ETKLSI--PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 892
Query: 2980 ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
++ EE+ RW++ + V ++LEE + L Q L+ W+ E ++ +
Sbjct: 893 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 952
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
P D +L Q +Q + ++ + + + +NE Q I S+++ EL+
Sbjct: 953 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKE 1010
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N +W + ++ +R + + K+ Q+ L ++ E + + + P+ +
Sbjct: 1011 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1070
Query: 3160 KQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE--QYLKDELKKRLETVALPLQGL 3217
++ +EE + + +Q + +VK L + ++ +I + ++ LKK LET+ Q L
Sbjct: 1071 QKAVEEMKRAKEEAQQKEAKVK---LLTESVNSVIAQAPPVAQEALKKELETLTTNYQWL 1127
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ L+ A + ++ WL++ + + I E + L E
Sbjct: 1128 CTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLE 1187
Query: 3278 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 3337
+ + ++ G + +L + W EL ++ RQ
Sbjct: 1188 NLMRHSEDNPNQIRILAQ------TLTDGGVMDELINEELETFNSRWRELHEEAVRRQKL 1241
Query: 3338 LKDCMQKAQKYQWHV-----------EDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSK 3386
L+ +Q AQ+ + + + L +I D K+ ++ + +++S L +
Sbjct: 1242 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD---KVDAAQMPQEAQKIQSDLTSHE 1298
Query: 3387 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRD--EKAGINQNMDAVTEELQAKTGS 3444
L E++K E AA +++ + + ++D K + Q + LQ
Sbjct: 1299 ISLEEMKKHNQGKE----AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1354
Query: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504
L+E+ L + K++E++V Q+ N + ++ EV +E
Sbjct: 1355 LDEVKMHLPALET--KSVEQEV--------------VQSQLNHCVNLYKSLSEVKSEVEM 1398
Query: 3505 QVDYLRNFTQGLVEDAPDGSD---ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
+ R Q + P D + LH E+ + E KQ++ C+ + K+
Sbjct: 1399 VIKTGRQIVQKKQTENPKELDERVTALKLHYNELG-AKVTERKQQLEK-CLKLSRKMRK- 1455
Query: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI-----EDVRLFLNKIHVLKLDI 3616
+ + LA D EL A+ +L S++ + K+H LK
Sbjct: 1456 -----EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH-LKSIT 1509
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL---GRVEDF 3673
E EA + +L ++ TL ++ +L LN +T R +E L L L +E F
Sbjct: 1510 EVGEA-LKTVLGKKETL----VEDKLSLLNSNWIAVTSRA---EEWLNLLLEYQKHMETF 1561
Query: 3674 YRKL----KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3729
+ + K + A T +E+E + QQ D K +++ ++ K+
Sbjct: 1562 DQNVDHITKWIIQADTLLDESEKKK----------PQQKEDVLKRLKAELNDIRPKVDST 1611
Query: 3730 NGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
L+ + G C + +E + E+N R+ ++ ++ GK L+
Sbjct: 1612 RDQAANLMANRGDHCR-KLVEPQISELNHRFAAISHRI------------KTGKASIPLK 1658
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
L + +D ++L+ +P AE + ++E+ + + +D + TV L G + Q
Sbjct: 1659 ELEQFNSDIQKLL---EPLEAEIQ-QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1714
Query: 3850 -AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908
+ RE+I + + L+++ L + R+K+ +I Q+ A+ + L E
Sbjct: 1715 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1774
Query: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
KKLA S P KI++ + L++ E QA + + +++ Q LS
Sbjct: 1775 KKLA-SLPEPRDERKIKE---IDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS 1830
Query: 3969 EKIDSLQARYSEI------QDRCCRKAALL----DQALSNARL---FGEDEVEVLNWLAE 4015
++ +++++++ Q R+ ++ D L + + + + V L E
Sbjct: 1831 KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE 1890
Query: 4016 VEDKLSS--VFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
VE L++ + KDF+ L +Q + + + +D A L+ T E
Sbjct: 1891 VEQLLNAPDLCAKDFED--LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 1948
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
+ +QE L + ++ + +++ + +F + WL E E+ L +
Sbjct: 1949 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT- 2007
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
Q P + +++ KEL+ + + + V+ T+N +++ L + + N
Sbjct: 2008 -QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLN 2066
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLE---QDQ 4250
+++ V + R ++ ++++ + + W+ E + I LE + Q
Sbjct: 2067 LRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN----IASIPLEPGKEQQ 2122
Query: 4251 TTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAI 4308
+L+ K ++ + + +L + E++ L+ K + Q+ +
Sbjct: 2123 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKV 2182
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE-EM 4367
S E+ +E + Q + E+L + ++ + + + Q Q+ ++
Sbjct: 2183 SRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 2242
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK---EEVRQR- 4423
++ ++ +P ++++L G L + P + V+ K + + + + +E+R +
Sbjct: 2243 QETEIAVQAKQPDVEEILSKGQHLYKEKPAT-QPVKRKLEDLSSEWKAVNRLLQELRAKQ 2301
Query: 4424 ------------------ALALDEAVSQSTQITEFHDKIEPMLET--------------- 4450
L V++ T I++ MLE
Sbjct: 2302 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2361
Query: 4451 -LENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4509
L L ++ ++ +++ I E I K+ +LE+ +P E L + L ++
Sbjct: 2362 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2421
Query: 4510 DKDLAAKEIQDKLDQMVFFWEDIKARAEER----------EIKFLDVLELAEKFWYDMAA 4559
+ A I D+++++ W++++ + R ++L+ E AE+ A
Sbjct: 2422 E---ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2478
Query: 4560 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4619
L + K+ V ++ + + + + +T + + L L+ +R AD
Sbjct: 2479 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD----- 2531
Query: 4620 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD----- 4674
+T K V + +N +W +++K ER LE+ + Q+ L+ WL
Sbjct: 2532 -DTRK--VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2588
Query: 4675 -NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4733
N + + D VK+ + + ++ + E+ L+ + +L+ D
Sbjct: 2589 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2648
Query: 4734 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4793
+++ L + W L +K + + LE + + +L+EL+ WL ++ L Q
Sbjct: 2649 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2708
Query: 4794 RPISGDPKVIEVELAKHHVLKNDVLAHQ----ATVETVN-------KAGNELL------- 4835
PI GD ++ + H K ++ + +T+ETV G E L
Sbjct: 2709 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2768
Query: 4836 --ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELT 4893
E A + LR + E +N WE + + + ++++ TL++ Q ++ L+L
Sbjct: 2769 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2828
Query: 4894 RMESQLSASKPTGG-LPETAREQLDTHMELYSQLKAKEETYNQLLDKGR-LMLLSRDDSG 4951
+ E + +P G L ++ ++ L+ L ++ +E + + D R L L S
Sbjct: 2829 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 2888
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
T + L +W ++ +E+R +L EA
Sbjct: 2889 YNLSTLED---LNTRWKLLQVAVEDRVRQLHEA 2918
Score = 226 bits (575), Expect = 7e-58
Identities = 493/2775 (17%), Positives = 1066/2775 (38%), Gaps = 371/2775 (13%)
Query: 1952 SEIDVDSLNLCLQQY-------EDLKQPMAERKAQLDALAFDIQFFISE-HAQDLSPQQN 2003
SE+++D L++ ED Q E ++ + QF E + DL+ Q
Sbjct: 214 SEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD--QFHTHEGYMMDLTAHQG 271
Query: 2004 R--QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC------- 2054
R +L+L ++L + + + E +V L + V +++KQ N
Sbjct: 272 RVGNILQLGSKLIGTGK-LSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 330
Query: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSF 2108
+Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 331 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 390
Query: 2109 ATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVAQK 2157
VV + G +EE L R R L +++ L EE +
Sbjct: 391 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 450
Query: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 451 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLLST 507
Query: 2218 SLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 2276
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 508 LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT---- 563
Query: 2277 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWLER 2335
+T EQ +++ E L + K+ T+ E++K L D E SW+ R
Sbjct: 564 -TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWITR 614
Query: 2336 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 2395
SE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 615 SEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 665
Query: 2396 EPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWMQA 2452
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 666 EQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTT 725
Query: 2453 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2512
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 726 AENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ--- 779
Query: 2513 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQNL 2570
+ + +HF+ + + R LQ QE++ ++ + + E L
Sbjct: 780 GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 839
Query: 2571 EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKL 2630
Q+S ++++ L L+ + Q+S L V + A S + Q +
Sbjct: 840 SIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEF 899
Query: 2631 AEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2683
E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 900 EEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD-- 957
Query: 2684 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDF 2743
+ + +Q + L +++ Q +L+++ ++ + + + ++ L +
Sbjct: 958 --SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1015
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIE 2802
+ + V R++ E+ +K + +W+ + E + + EL+K +E
Sbjct: 1016 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1075
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+K ++ K V+ + T N ++ P +Q
Sbjct: 1076 EMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ--------------------- 1110
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1111 -----EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1165
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQEAE 2980
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1166 LKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE--- 1220
Query: 2981 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 3040
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1221 -----LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA 1275
Query: 3041 LSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 3097
+D + + Q++Q L E ++H Q EAAQ +L+ QK+L
Sbjct: 1276 DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQKKL 1328
Query: 3098 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE 3157
Q ++ K+ + K +++ LQ+ + V L S + E
Sbjct: 1329 QDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQE 1373
Query: 3158 AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLETV 3210
V+ QL + L ++ EV E+ + G Q ++ EL +R+ +
Sbjct: 1374 VVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVTAL 1425
Query: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
L L +R +L+ L +++ ++ + L WL + K + L
Sbjct: 1426 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1485
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
S++ + QK + + + I GE+L + G+++ ++++L L ++W ++ +
Sbjct: 1486 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVTSR 1543
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
+ + L + + + + +V+ + WI + E P Q E L R KA LN
Sbjct: 1544 AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELN 1602
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LEEM 3448
++ R + + AA+++ N + + + + +N A++ ++ S L+E+
Sbjct: 1603 DI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL 1660
Query: 3449 TQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSNKN 3488
Q + Q+ + +E +++ K L+ D L + +
Sbjct: 1661 EQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1720
Query: 3489 LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3548
E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ + ++
Sbjct: 1721 REEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKCLD 1771
Query: 3549 SGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDVRL 3604
+E KL + + +++E+ +L +EL+ + A G D +E ++
Sbjct: 1772 D----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI 1827
Query: 3605 FLNK-------------------IHVLK----------LDIEASE------AECRH---- 3625
L+K IH ++ + +E S E H
Sbjct: 1828 QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQA 1887
Query: 3626 MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K +
Sbjct: 1888 LLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 1943
Query: 3685 TAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFKMF 3714
T E EAL QW +++I NQ L + + F
Sbjct: 1944 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2003
Query: 3715 QKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753
++ P Q ++ +N G+ +IQ + K D L+ +
Sbjct: 2004 LRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQEKL 2062
Query: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3813
+N RW + K+++ R +L+E +FQ L + WL + + + + P E +
Sbjct: 2063 GSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQ 2122
Query: 3814 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRWTE 3871
+K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W +
Sbjct: 2123 -LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2181
Query: 3872 ----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQTAK 3923
L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2182 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2241
Query: 3924 IQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------AEQ 3964
+Q+ I +A + D+E + K + + L L+S A+Q
Sbjct: 2242 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2301
Query: 3965 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEVLN 4011
L+ + ++ A ++ + + A+S + F E+ +
Sbjct: 2302 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2361
Query: 4012 WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE 4071
WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+ +
Sbjct: 2362 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2421
Query: 4072 EV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 4130
E +I ++++ I+ ++ ++ + L + + +T++ EE L + +L
Sbjct: 2422 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2481
Query: 4131 TSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 4190
+ T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2482 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 2541
Query: 4191 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----- 4245
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2542 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2601
Query: 4246 LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESLIQ 4303
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2602 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2661
Query: 4304 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 4363
++ + + + LE + + + +EL W++ +++ D +++Q
Sbjct: 2662 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2721
Query: 4364 QEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAENMY 4413
+ R + + +P I L+ L++L E E+ EE+ Q +
Sbjct: 2722 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2781
Query: 4414 AQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 4472
+ EEV L+ + +I E ++++ + E + L +LR +I +
Sbjct: 2782 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2841
Query: 4473 ECISDNKSATVELEK 4487
+ + D+ +E K
Sbjct: 2842 DLLIDSLQDHLEKVK 2856
Score = 204 bits (518), Expect = 3e-51
Identities = 414/2141 (19%), Positives = 854/2141 (39%), Gaps = 303/2141 (14%)
Query: 1804 LEHDEKLVSYLSLLRNIEMRTKQIQP----LELNLAELQDLLCQAKVLERELKDLTTLVS 1859
+EH +KL ++ LR I+ + ++ +++ L E L +++L+++LK LVS
Sbjct: 914 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVS 973
Query: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK 1919
+++ + + S + +A + A L+ L ++ W+ H V K
Sbjct: 974 -DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD----HMCQQVYARKEA 1028
Query: 1920 V---LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER 1976
+ L + L+ L ++ W+ + + D L +++ + K+ ++
Sbjct: 1029 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQK 1087
Query: 1977 KAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQ 2036
+A++ L + I++ P + + L L ++Q + + +
Sbjct: 1088 EAKVKLLTESVNSVIAQ----APPVAQEALKKELETLTTNYQWLCTRLNGK--------- 1134
Query: 2037 QMEQEALVKTLQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQ------QDLSAL 2087
KTL++ H+ LE W+ + E L +TT+ +++S +
Sbjct: 1135 -------CKTLEEVWACWHELLSYLEKANKWLNEVEFKL-----KTTENIPGGAEEISEV 1182
Query: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
+ +L +D N+ A + D G M+E + E+L ++
Sbjct: 1183 LDSLENLMRHSEDNPNQIRILAQTLTD-GGVMDE-----------LINEELETFNSRWRE 1230
Query: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 2207
L EE QK LE+++ SA QETEKS + E+ ID L + Q+
Sbjct: 1231 LHEEAVRRQKLLEQSIQSA--QETEKS--LHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1286
Query: 2208 LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE------LLSQQQNF 2261
++ S + + +L+ + +A +++ Q ++ + + Q+ L + NF
Sbjct: 1287 AQKIQ--SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF 1344
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ---------- 2311
Q ++ LD+ +L E + ++Q++ + + + +L +S +E+K
Sbjct: 1345 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1404
Query: 2312 --VQTLQDELQKFLQD---------------------------------HKEFE---SWL 2333
VQ Q E K L + KE WL
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
++ EL P L S + + +++ K L+ +T G+ + +
Sbjct: 1465 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----L 1519
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWM 2450
GK+ + LV+DKL + A+ S R LN+LL Q H F + D + W+
Sbjct: 1520 GKKET----LVEDKLSLLNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI 1572
Query: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2510
+ LL ++ P Q++ K+L+ EL + + V+ + A ++M G
Sbjct: 1573 ----IQADTLLDESEKKKP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-- 1623
Query: 2511 APDH-RHVQETTDSILSH-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSI 2563
DH R + E S L+H F ++S+ + ++S+ K + Q Q + E LE+ +Q
Sbjct: 1624 --DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1681
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTT 2622
+++ K ++ + G ++E L L+Q I ++ E ++ + + A
Sbjct: 1682 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2682
+ + K E+S ++ Q ++ + L + +++ + LAS
Sbjct: 1742 RSQRRKKALEISHQWYQ---------------------YKRQADDLLKCLDDIEKKLASL 1780
Query: 2683 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
+P + ++I+E++ E++ ++E L+ + LS G A+ + +
Sbjct: 1781 PEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV------------E 1823
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
T++Q + + RE ++ Q + F + + T ++ P E S +I
Sbjct: 1824 PTQIQLSKRWREIESKFAQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEIT 1882
Query: 2803 HLKSLL---------DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS 2853
H+ L D +K E++ + SL+N+ DS ++ + + S
Sbjct: 1883 HVSQALLEVEQLLNAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHS 1934
Query: 2854 SVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVL 2913
+ T + ++Q +S ++ ++EK+ + +RQ + + H +
Sbjct: 1935 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 1994
Query: 2914 QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---L 2970
QWL E+ L+ P E K K +L EL+ + Q V L +
Sbjct: 1995 QWLTEAEQFLRKTQI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEI 2046
Query: 2971 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 3030
+ + +A ++ LN RW+ + R+++LEE + L+ FQ ++ WL E
Sbjct: 2047 IQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE 2106
Query: 3031 KELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
+ + + PL L + +QV+ +++E R+ +QLNE +L
Sbjct: 2107 ADNIASI--PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE 2164
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV- 3148
+++ +L+ N +W++++ L + +I+ I Q ++ L+DL E++ + LS
Sbjct: 2165 QDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2224
Query: 3149 --QSAISTQPE------------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLI 3194
Q I QP AV+ + + EI S + L E Q + +L L
Sbjct: 2225 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2284
Query: 3195 GEQYLKDELKKRL-------------------ETVALPLQGL--EDLAADRI---NRLQA 3230
E + L + L +TV L Q + ++ A ++ + L
Sbjct: 2285 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLML 2344
Query: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
+ + F + + EL WL + LE + + + + + L Q
Sbjct: 2345 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 2404
Query: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
E ++ ++L E + + +++ ++N W+E+ + +R+ +L + ++ + ++
Sbjct: 2405 EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 2464
Query: 3351 HVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407
E+ + +AK+ + T+D +Q + +K + ++ + ++ +++ N A
Sbjct: 2465 AKEEAEQVLGQARAKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLAL 2522
Query: 3408 ILINSSEADED-GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIE 3463
L+ AD+ + IN + ++ + + + +LEE + L++F E F
Sbjct: 2523 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 2582
Query: 3464 KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVED 3519
+ E + L+ +K +++L Q + LQ +E D N +Q ++
Sbjct: 2583 TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS 2642
Query: 3520 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3579
DA L + + ++ E++++ + +E + + H ++E+ L D
Sbjct: 2643 LEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2702
Query: 3580 DELDGMGAIGRDTDSLQSQ---------------------IEDVRLFLNKIHVLKLDIEA 3618
DEL IG D ++Q Q +E VR+FL + + L E
Sbjct: 2703 DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EK 2760
Query: 3619 SEAECRHMLEEEGTLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKL 3677
E R + EE ++ L+++ E +N + KL Q +++ TL R+++
Sbjct: 2761 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2820
Query: 3678 KGLNDATTAAEEAEALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
L+ AE + VG ++ + L K + E + PL+ + VN L + L
Sbjct: 2821 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL 2879
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777
+ G L +E++N RW L V R+ QL EA
Sbjct: 2880 -TTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHEA 2918
Score = 194 bits (492), Expect = 3e-48
Identities = 469/2759 (16%), Positives = 1097/2759 (39%), Gaps = 318/2759 (11%)
Query: 1807 DEKLVSYLSLLRNIEMRTKQIQ--PLELNLAELQDLLCQAKVLERELKDLTTLVSQELEC 1864
++KL L E RT++++ PL +L +L+ + Q KVL+ +L+ V+
Sbjct: 331 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 390
Query: 1865 VNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQH 1924
V + S A ALE+ K L +++ R + Q+ +L +
Sbjct: 391 VVVVDESSGDHATA----ALEEQLKVLGDRWANICRWTEDRWVLLQD--------ILLKW 438
Query: 1925 TQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA 1984
+L AW+ K +N + D + + LQ+ LK + ++K + L
Sbjct: 439 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 498
Query: 1985 FDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV 2044
Q +S Q+ L + LE++ AQ+ +A+
Sbjct: 499 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS-----------QAVT 547
Query: 2045 KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 2104
T Q + + + + V E+ L H Q++L + + +I+ R
Sbjct: 548 TT---QPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDSEIRKR 600
Query: 2105 A----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQEETRV 2154
T + + E ++ + + +E + L+EK++ + E++ LQ+ +R
Sbjct: 601 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660
Query: 2155 AQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLLTNLPG 2210
AQ +E+ V + ++ K +A+++L E + + L+W+ + L
Sbjct: 661 AQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQ 718
Query: 2211 MEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270
+EQ++ + + T P + Q ++ K L Q I +
Sbjct: 719 LEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERLKIQSI 772
Query: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKE 2328
L + G L + + +A K++QT+ D L ++ +
Sbjct: 773 ALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSA 827
Query: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
+W+++SE +L + E + L + + + L +++ + +++
Sbjct: 828 IRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM---- 883
Query: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
K PSEI + + ++ R+ L S+ L + + + QN +L+
Sbjct: 884 ----SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 939
Query: 2449 WMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
WM A V+ L + D +L++QL KQ + +++ Q L V +I
Sbjct: 940 WM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNEGGQKI 992
Query: 2507 EGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2565
+ E P+ ET + + + + + R L+ + ++ S+Q+ L + + + +
Sbjct: 993 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1052
Query: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1053 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1112
Query: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRMLASGNQ 2684
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++ + N
Sbjct: 1113 LKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENI 1172
Query: 2685 PD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1173 PGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LETFNSR 1227
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
+ EL + R+K L+ + +ETE S+ + S++ ++KQ+
Sbjct: 1228 WRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--IDKQLA 1271
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+ D A ++I TS E + +E +QGK +
Sbjct: 1272 AYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA--------------QR 1316
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
+ Q + DV++K+ L ++ + + L + + E L LE+K
Sbjct: 1317 VLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALETKS-- 1369
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2982
+ E V++Q L + +++ V + ++ ++ EN
Sbjct: 1370 ----------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKKQTENP 1415
Query: 2983 KKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
K++ E + + E+ R++QLE+ + + L WL ++ +
Sbjct: 1416 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1475
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
+ P+ L+++ + KE E ++ + + E + + T G + V+ +L
Sbjct: 1476 AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVEDKLSL 1532
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N W+ +T S+ ++ + +YQ+ ++ + V + + + + + E
Sbjct: 1533 LNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKK 1585
Query: 3160 KQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217
K Q +E ++++L + +V + L G D +K +E L
Sbjct: 1586 KPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQISELNHR 1640
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ RI +A++ ++ +Q +++ L+ P+ A+++ Q + E
Sbjct: 1641 FAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGVNLKEE 1687
Query: 3278 EFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 3336
+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L + R+
Sbjct: 1688 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1747
Query: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVE 3393
+ + + +Y+ +DL+ ++D + K++ L D +++ L + K LN V
Sbjct: 1748 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1807
Query: 3394 KRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL--EEMT 3449
++ L +A + + + I + A + A ++ +T + E+M
Sbjct: 1808 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1867
Query: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP----- 3504
+ ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1868 LEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQS 1925
Query: 3505 --QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEG 3560
++D + + ++ A + ++ Q ++Q +F +V + + +E
Sbjct: 1926 SGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEK 1982
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEA 3618
+FH ++ +F+Q ++ I + + + + +++++ + + + + A
Sbjct: 1983 WRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2041
Query: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGRVEDFY 3674
+ E ++++ D L+ +L +LN + C +L++R K +EQ + + +F
Sbjct: 2042 TGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQ 2094
Query: 3675 RKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVN 3730
R L N+ EEA+ + + G E ++ ++L K+ +E PL+ L+Q+N
Sbjct: 2095 RDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLN 2148
Query: 3731 GLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+ + LE
Sbjct: 2149 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2208
Query: 3790 PL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
L L WL+ + P+ E +QE ++ + ++ V+ + ++
Sbjct: 2209 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVEEILSK 2262
Query: 3843 GGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------------ 3887
G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2263 GQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2320
Query: 3888 -----VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEPVGTQT 3921
V+ K+ F+ ++D+LS+ ++ + + +
Sbjct: 2321 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2380
Query: 3922 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSE 3980
I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q ++ E
Sbjct: 2381 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2440
Query: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADH 4040
+Q+ + L++ L ++ + E + E L + KL S + D + ++ +
Sbjct: 2441 VQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITET 2500
Query: 4041 LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 4100
L +++ + NVD A LL+ + ++ + + I + I S+
Sbjct: 2501 KQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAA 2560
Query: 4101 LEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQKELKK 4154
LE+ +L +F E+ WL E E ++ + + + ++ ++L+
Sbjct: 2561 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2620
Query: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTIGQRVD 4208
E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2621 EIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2675
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF------- 4261
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2676 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2735
Query: 4262 ------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAI 4308
+++ +R + +++L+ E+ + T +L+++ E + ++E +
Sbjct: 2736 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2795
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEM 4367
+L +++ +++ + + E +EL + + + P + + L+ E++
Sbjct: 2796 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2855
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
+ LR IA K ++ + + QL +L+P +E+ + + + +++ VRQ
Sbjct: 2856 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 2914
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3831
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 209 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 268
Query: 3832 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3889
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 269 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 326
Query: 3890 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 327 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
+ + + L E++ L R++ I + LL L + E++
Sbjct: 387 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 446
Query: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 4066
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 447 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 506
Query: 4067 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 4113
+ V E D + + T S+A+ T + + T ++
Sbjct: 507 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 566
Query: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 4172
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 567 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 620
Query: 4173 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 4215
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 621 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 680
Query: 4216 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 4259
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 681 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 740
Query: 4260 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 4312
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 741 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 798
Query: 4313 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 4426
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 859 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 908
Query: 4427 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 4472
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 909 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 962
Query: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 963 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1018
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1078
Query: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1079 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1138
Query: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4708
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1139 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1198
Query: 4709 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4768
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1199 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1248
Query: 4769 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1249 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1305
Query: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1306 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1351
Query: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4948
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1352 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1410
Query: 4949 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 5008
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1411 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Query: 5009 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 5068
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1471 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1529
Query: 5069 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 5099
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1530 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1589
Query: 5100 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 5129
+ K+L L D +DS + ++N D
Sbjct: 1590 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1649
Query: 5130 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1650 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1709
Query: 5188 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 5233
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1710 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1768
Query: 5234 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 5287
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1769 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1826
Query: 5288 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 5347
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1827 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 1883
Query: 5348 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 1884 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 1943
Query: 5396 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 5444
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 1944 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2003
Query: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5504
L + IP+N + K ++ +++E+ V +T
Sbjct: 2004 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2040
Query: 5505 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5564
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2041 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2093
Query: 5565 KEFANFDFDVW 5575
+ N +F +W
Sbjct: 2094 QRDLN-EFVLW 2103
Score = 91.3 bits (225), Expect = 3e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 5087 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 5146
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 208 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 267
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 268 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327
Query: 5206 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 5263
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 328 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 385
Query: 5264 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 5322
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 386 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 445
Query: 5323 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 5380
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 446 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 504
Query: 5381 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 5437
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 505 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 564
Query: 5438 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 5494
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 565 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 618
Query: 5495 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5554
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 619 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 674
Query: 5555 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5614
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 675 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 730
Query: 5615 LASKFPTTKLEMTAV 5629
PTT E TA+
Sbjct: 731 --KIQPTTPSEPTAI 743
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 380 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 439
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2832
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 440 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491
Query: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2892
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 492 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 547
Query: 2893 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2950
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 607
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2991
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 608 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667
Query: 2992 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 3024
T+ TV ++RQ+ + ++L
Sbjct: 668 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 727
Query: 3025 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 3083
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 728 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 787
Query: 3084 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 788 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 846
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 3202
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 847 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 885
Query: 3203 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 3241
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 886 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 943
Query: 3242 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 3300
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 944 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 1001
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 1002 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1061
Query: 3361 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 3418
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 1062 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1121
Query: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 3477
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1122 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1181
Query: 3478 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1182 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1240
Query: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1241 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1293
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3654
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1294 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1352
Query: 3655 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3714
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1353 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1392
Query: 3715 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3772
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1393 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1439
Query: 3773 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619
Query: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1620 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1678
Query: 4001 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 4058
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1679 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1731
Query: 4059 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 4116
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1732 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
Query: 4117 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 4167
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1851
Query: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 4222
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1852 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1909
Query: 4223 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1910 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1961
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
F Q ++E+T ++ + + + + + + +S
Sbjct: 1962 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2006
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 4398
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 2007 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2066
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 4458
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2123
Query: 4459 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4516
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2124 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2176
Query: 4517 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4576
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2177 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2235
Query: 4577 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4634
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2236 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2294
Query: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4694
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2295 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2351
Query: 4695 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4739
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2352 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2411
Query: 4740 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4772
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2412 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2471
Query: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2472 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2531
Query: 4833 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2532 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2591
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2592 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2650
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2651 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2710
Query: 5012 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 5064
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2711 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2770
Query: 5065 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2771 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2830
Query: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 5170
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2831 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2890
Query: 5171 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 5225
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2950
Query: 5226 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 5283
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2951 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3009
Query: 5284 KGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
L++L+TRW L V+ + R+ Q
Sbjct: 3010 LSTLEDLNTRWKL---LQVAVEDRVRQ 3033
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2772 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2828
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 324 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
Query: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2888
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 379 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 434
Query: 2889 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2948
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 435 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 492
Query: 2949 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2998
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 493 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 552
Query: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 3057
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 553 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 601
Query: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 3117
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 660
Query: 3118 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 3171
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 661 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 719
Query: 3172 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 3213
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 720 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 779
Query: 3214 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 3258
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 780 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 839
Query: 3259 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 840 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 896
Query: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 3364
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 897 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 956
Query: 3365 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 3421
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 957 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015
Query: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 3480
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075
Query: 3481 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3540
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1134
Query: 3541 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3600
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1135 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1194
Query: 3601 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3660
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1195 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1254
Query: 3661 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
+ LE + L+ N E + E I++ L + + D
Sbjct: 1255 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1314
Query: 3721 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1315 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1365
Query: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3839
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1366 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1423
Query: 3840 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3897
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1424 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1463
Query: 3898 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1464 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
Query: 3954 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 4013
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
Query: 4014 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1584 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1642
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1643 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1702
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1703 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1757
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 4253
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1758 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1811
Query: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1812 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1862
Query: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 4373
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1863 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1921
Query: 4374 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 4419
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1922 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1979
Query: 4420 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 4479
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1980 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 2035
Query: 4480 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4539
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 2036 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 2091
Query: 4540 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4596
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 2092 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2143
Query: 4597 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4653
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2144 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2203
Query: 4654 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4713
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2204 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2262
Query: 4714 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2322
Query: 4773 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4823
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2323 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2374
Query: 4824 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4880
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2375 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2432
Query: 4881 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2433 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2492
Query: 4931 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4962
E N+++ K + + L S ++T +
Sbjct: 2493 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2552
Query: 4963 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 5022
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2553 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2612
Query: 5023 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 5082
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2613 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2672
Query: 5083 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 5136
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2673 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2732
Query: 5137 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 5196
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2733 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2792
Query: 5197 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 5256
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2793 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2852
Query: 5257 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 5295
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2853 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2912
Query: 5296 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 5355
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2913 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2966
Query: 5356 HKEFMKKVEEKRVDV 5370
++ ++KV+ R ++
Sbjct: 2967 LQDHLEKVKALRGEI 2981
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2834 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2890
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 273 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 332
Query: 2891 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2950
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 333 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 383
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 3007
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 384 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 441
Query: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 3065
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 442 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 499
Query: 3066 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 3125
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 500 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 546
Query: 3126 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 3185
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 547 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 591
Query: 3186 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 3245
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 592 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 643
Query: 3246 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 3304
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 644 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 701
Query: 3305 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 3364
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 702 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 736
Query: 3365 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 3419
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 737 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 796
Query: 3420 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 3479
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 797 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 855
Query: 3480 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3535
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 856 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 914
Query: 3536 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3590
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 915 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 965
Query: 3591 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3649
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 966 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 1025
Query: 3650 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3709
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 1026 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 1085
Query: 3710 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3769
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 1086 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1143
Query: 3770 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3826
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1144 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1200
Query: 3827 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3886
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1201 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1260
Query: 3887 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1261 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1317
Query: 3947 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 4006
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1318 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1374
Query: 4007 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 4065
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1375 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1432
Query: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1433 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1477
Query: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1478 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1537
Query: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1538 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1597
Query: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1598 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1646
Query: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 4362
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1647 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706
Query: 4363 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 4416
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1763
Query: 4417 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 4475
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1764 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1813
Query: 4476 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4535
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1814 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1860
Query: 4536 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4595
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1861 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1919
Query: 4596 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4650
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1920 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1979
Query: 4651 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4700
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1980 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 2034
Query: 4701 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4760
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 2035 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 2093
Query: 4761 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 2094 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2150
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2151 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2210
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2211 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2269
Query: 4940 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4998
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2270 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2329
Query: 4999 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 5051
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2330 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2383
Query: 5052 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 5081
L +K +K L + S W+ V +
Sbjct: 2384 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
Query: 5082 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621
Query: 5251 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 5309
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
Query: 5310 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 5367
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2682 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2738
Query: 5368 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2739 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2798
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2799 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2856
Query: 5480 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5537
+ +E E+ G K +P PP + + + +++
Sbjct: 2857 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2908
Query: 5538 ARWQQVWLLALERQRKLNDALDRLEELKE 5566
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2909 TEWEKLNLHSADWQRKIDETLERLQELQE 2937
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 339 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
Query: 2498 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2557
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 397 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 454
Query: 2558 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 455 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 514
Query: 2616 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2671
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 515 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 574
Query: 2672 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2731
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 575 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 634
Query: 2732 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2778
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 635 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 692
Query: 2779 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2828
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
Query: 2829 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2879
+L ++ A + Q + S V V + K +E +N
Sbjct: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 806
Query: 2880 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 857
Query: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2990
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 911
Query: 2991 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 3048
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
Query: 3049 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 3107
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1028
Query: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 3167
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088
Query: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 3223
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 1089 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139
Query: 3224 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 3279
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1140 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1199
Query: 3280 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 3339
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1200 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1258
Query: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 3398
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1259 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1318
Query: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1319 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
Query: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1375 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1430
Query: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3578
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1431 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1477
Query: 3579 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1478 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1537
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3698
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1538 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1597
Query: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3758
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1598 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1654
Query: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3816
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1714
Query: 3817 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3872
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1715 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1767
Query: 3873 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3930
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1768 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1804
Query: 3931 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3988
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1805 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1864
Query: 3989 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 4041
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1865 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1919
Query: 4042 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 4096
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1920 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1976
Query: 4097 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 4151
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1977 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2036
Query: 4152 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 2037 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
Query: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 4270
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 2097 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2153
Query: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2154 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2213
Query: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2214 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2272
Query: 4391 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2273 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2329
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2330 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2383
Query: 4508 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2384 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2431
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
SP +++ Q V ET K E
Sbjct: 2432 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2456
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
+ S+ A + N+ W E + DWL + + +
Sbjct: 2457 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2495
Query: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2616 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2675
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4920
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2676 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2735
Query: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2736 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2795
Query: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2796 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2855
Query: 5041 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 5080
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2856 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2915
Query: 5081 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2916 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2972
Query: 5141 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 5198
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2973 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3032
Query: 5199 KLEEA 5203
+L EA
Sbjct: 3033 QLHEA 3037
Score = 244 bits (622), Expect = 2e-63
Identities = 502/2853 (17%), Positives = 1100/2853 (38%), Gaps = 303/2853 (10%)
Query: 2296 EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355
+ + +SL +SE L + QT +E+ SWL +E L+ + + E +
Sbjct: 324 KSFGSSLMESEVNLDRYQTALEEVL----------SWLLSAEDTLQAQGEISNDVEVVKD 373
Query: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415
+ D+ +H+G + + G K++ GK + V++++ R+
Sbjct: 374 QFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQEQMNLLNSRW 427
Query: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475
L S+L+ +L L W+ E K+ + + D L+ Q
Sbjct: 428 ECLRVASMEKQSNLHRVLMDLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 485
Query: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ----------------- 2518
+ K LQE+L + QV V L + + E G+ A Q
Sbjct: 486 VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 545
Query: 2519 --ETTDSILSHFQSL-------SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569
IL +Q L S L+E+ + K Q + S LQ + ++ +
Sbjct: 546 RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 605
Query: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2629
LE K+ S +++ L + +K K + ++ L+ ++ + +TA + Q
Sbjct: 606 LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 665
Query: 2630 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ----P 2685
+ ++ ++ +++L +H +L K R + ++
Sbjct: 666 TTTQPSLTQTTVMETVTTVTTREQIL-----VKHAQEELPPPPPQKKRQITVDSEIRKRL 720
Query: 2686 DQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL--DLCQHQDRVQNLRKDF 2743
D DIT I ++ + + E ++L A+ + + ++Q+ +
Sbjct: 721 DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 780
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEH 2803
L + + +A S ++ ++ F + L E + ++ +Q+E
Sbjct: 781 QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 840
Query: 2804 LKSLLDDWAS-KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS-SVGSVNGY 2861
+ + ++W + T E + L+ D + + P + + S+
Sbjct: 841 MTTTAENWLKIQPTTPSEPTAIKSQLK------ICKDEVNRLSGLQPQIERLKIQSIALK 894
Query: 2862 HTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV-HKEANSVLQ-WLESK 2919
+ + D ++++ + R++ LQ I + + + ++E S ++ W++
Sbjct: 895 EKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS 954
Query: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEA 2979
E L S T E ++ + +A + L++ + + + + P S+ +
Sbjct: 955 ETKLSI--PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1011
Query: 2980 ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
++ EE+ RW++ + V ++LEE + L Q L+ W+ E ++ +
Sbjct: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
P D +L Q +Q + ++ + + + +NE Q I S+++ EL+
Sbjct: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKE 1129
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N +W + ++ +R + + K+ Q+ L ++ E + + + P+ +
Sbjct: 1130 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1189
Query: 3160 KQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE--QYLKDELKKRLETVALPLQGL 3217
++ +EE + + +Q + +VK L + ++ +I + ++ LKK LET+ Q L
Sbjct: 1190 QKAVEEMKRAKEEAQQKEAKVK---LLTESVNSVIAQAPPVAQEALKKELETLTTNYQWL 1246
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ L+ A + ++ WL++ + + I E + L E
Sbjct: 1247 CTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLE 1306
Query: 3278 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 3337
+ + ++ G + +L + W EL ++ RQ
Sbjct: 1307 NLMRHSEDNPNQIRILAQ------TLTDGGVMDELINEELETFNSRWRELHEEAVRRQKL 1360
Query: 3338 LKDCMQKAQKYQWHV-----------EDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSK 3386
L+ +Q AQ+ + + + L +I D K+ ++ + +++S L +
Sbjct: 1361 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD---KVDAAQMPQEAQKIQSDLTSHE 1417
Query: 3387 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRD--EKAGINQNMDAVTEELQAKTGS 3444
L E++K E AA +++ + + ++D K + Q + LQ
Sbjct: 1418 ISLEEMKKHNQGKE----AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1473
Query: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504
L+E+ L + K++E++V Q+ N + ++ EV +E
Sbjct: 1474 LDEVKMHLPALET--KSVEQEV--------------VQSQLNHCVNLYKSLSEVKSEVEM 1517
Query: 3505 QVDYLRNFTQGLVEDAPDGSD---ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
+ R Q + P D + LH E+ + E KQ++ C+ + K+
Sbjct: 1518 VIKTGRQIVQKKQTENPKELDERVTALKLHYNELG-AKVTERKQQLEK-CLKLSRKMRK- 1574
Query: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI-----EDVRLFLNKIHVLKLDI 3616
+ + LA D EL A+ +L S++ + K+H LK
Sbjct: 1575 -----EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH-LKSIT 1628
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL---GRVEDF 3673
E EA + +L ++ TL ++ +L LN +T R +E L L L +E F
Sbjct: 1629 EVGEA-LKTVLGKKETL----VEDKLSLLNSNWIAVTSRA---EEWLNLLLEYQKHMETF 1680
Query: 3674 YRKL----KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3729
+ + K + A T +E+E + QQ D K +++ ++ K+
Sbjct: 1681 DQNVDHITKWIIQADTLLDESEKKK----------PQQKEDVLKRLKAELNDIRPKVDST 1730
Query: 3730 NGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
L+ + G C + +E + E+N R+ ++ ++ GK L+
Sbjct: 1731 RDQAANLMANRGDHCR-KLVEPQISELNHRFAAISHRI------------KTGKASIPLK 1777
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
L + +D ++L+ +P AE + ++E+ + + +D + TV L G + Q
Sbjct: 1778 ELEQFNSDIQKLL---EPLEAEIQ-QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833
Query: 3850 -AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908
+ RE+I + + L+++ L + R+K+ +I Q+ A+ + L E
Sbjct: 1834 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1893
Query: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
KKLA S P KI++ + L++ E QA + + +++ Q LS
Sbjct: 1894 KKLA-SLPEPRDERKIKE---IDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS 1949
Query: 3969 EKIDSLQARYSEI------QDRCCRKAALL----DQALSNARL---FGEDEVEVLNWLAE 4015
++ +++++++ Q R+ ++ D L + + + + V L E
Sbjct: 1950 KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE 2009
Query: 4016 VEDKLSS--VFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
VE L++ + KDF+ L +Q + + + +D A L+ T E
Sbjct: 2010 VEQLLNAPDLCAKDFED--LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2067
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
+ +QE L + ++ + +++ + +F + WL E E+ L +
Sbjct: 2068 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT- 2126
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
Q P + +++ KEL+ + + + V+ T+N +++ L + + N
Sbjct: 2127 -QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLN 2185
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLE---QDQ 4250
+++ V + R ++ ++++ + + W+ E + I LE + Q
Sbjct: 2186 LRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN----IASIPLEPGKEQQ 2241
Query: 4251 TTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAI 4308
+L+ K ++ + + +L + E++ L+ K + Q+ +
Sbjct: 2242 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKV 2301
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE-EM 4367
S E+ +E + Q + E+L + ++ + + + Q Q+ ++
Sbjct: 2302 SRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 2361
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK---EEVRQR- 4423
++ ++ +P ++++L G L + P + V+ K + + + + +E+R +
Sbjct: 2362 QETEIAVQAKQPDVEEILSKGQHLYKEKPAT-QPVKRKLEDLSSEWKAVNRLLQELRAKQ 2420
Query: 4424 ------------------ALALDEAVSQSTQITEFHDKIEPMLET--------------- 4450
L V++ T I++ MLE
Sbjct: 2421 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2480
Query: 4451 -LENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4509
L L ++ ++ +++ I E I K+ +LE+ +P E L + L ++
Sbjct: 2481 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2540
Query: 4510 DKDLAAKEIQDKLDQMVFFWEDIKARAEER----------EIKFLDVLELAEKFWYDMAA 4559
+ A I D+++++ W++++ + R ++L+ E AE+ A
Sbjct: 2541 E---ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2597
Query: 4560 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4619
L + K+ V ++ + + + + +T + + L L+ +R AD
Sbjct: 2598 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD----- 2650
Query: 4620 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD----- 4674
+T K V + +N +W +++K ER LE+ + Q+ L+ WL
Sbjct: 2651 -DTRK--VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2707
Query: 4675 -NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4733
N + + D VK+ + + ++ + E+ L+ + +L+ D
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2767
Query: 4734 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4793
+++ L + W L +K + + LE + + +L+EL+ WL ++ L Q
Sbjct: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827
Query: 4794 RPISGDPKVIEVELAKHHVLKNDVLAHQ----ATVETVN-------KAGNELL------- 4835
PI GD ++ + H K ++ + +T+ETV G E L
Sbjct: 2828 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2887
Query: 4836 --ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELT 4893
E A + LR + E +N WE + + + ++++ TL++ Q ++ L+L
Sbjct: 2888 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2947
Query: 4894 RMESQLSASKPTGG-LPETAREQLDTHMELYSQLKAKEETYNQLLDKGR-LMLLSRDDSG 4951
+ E + +P G L ++ ++ L+ L ++ +E + + D R L L S
Sbjct: 2948 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3007
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
T + L +W ++ +E+R +L EA
Sbjct: 3008 YNLSTLED---LNTRWKLLQVAVEDRVRQLHEA 3037
Score = 226 bits (575), Expect = 7e-58
Identities = 493/2775 (17%), Positives = 1066/2775 (38%), Gaps = 371/2775 (13%)
Query: 1952 SEIDVDSLNLCLQQY-------EDLKQPMAERKAQLDALAFDIQFFISE-HAQDLSPQQN 2003
SE+++D L++ ED Q E ++ + QF E + DL+ Q
Sbjct: 333 SEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD--QFHTHEGYMMDLTAHQG 390
Query: 2004 R--QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC------- 2054
R +L+L ++L + + + E +V L + V +++KQ N
Sbjct: 391 RVGNILQLGSKLIGTGK-LSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 449
Query: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSF 2108
+Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 450 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
Query: 2109 ATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVAQK 2157
VV + G +EE L R R L +++ L EE +
Sbjct: 510 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 569
Query: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 570 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLLST 626
Query: 2218 SLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 2276
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 627 LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT---- 682
Query: 2277 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWLER 2335
+T EQ +++ E L + K+ T+ E++K L D E SW+ R
Sbjct: 683 -TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWITR 733
Query: 2336 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 2395
SE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 734 SEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 784
Query: 2396 EPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWMQA 2452
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 785 EQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTT 844
Query: 2453 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2512
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 845 AENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ--- 898
Query: 2513 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQNL 2570
+ + +HF+ + + R LQ QE++ ++ + + E L
Sbjct: 899 GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 958
Query: 2571 EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKL 2630
Q+S ++++ L L+ + Q+S L V + A S + Q +
Sbjct: 959 SIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEF 1018
Query: 2631 AEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2683
E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 1019 EEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD-- 1076
Query: 2684 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDF 2743
+ + +Q + L +++ Q +L+++ ++ + + + ++ L +
Sbjct: 1077 --SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1134
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIE 2802
+ + V R++ E+ +K + +W+ + E + + EL+K +E
Sbjct: 1135 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1194
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+K ++ K V+ + T N ++ P +Q
Sbjct: 1195 EMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ--------------------- 1229
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1230 -----EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1284
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQEAE 2980
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1285 LKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE--- 1339
Query: 2981 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 3040
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1340 -----LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA 1394
Query: 3041 LSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 3097
+D + + Q++Q L E ++H Q EAAQ +L+ QK+L
Sbjct: 1395 DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQKKL 1447
Query: 3098 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE 3157
Q ++ K+ + K +++ LQ+ + V L S + E
Sbjct: 1448 QDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQE 1492
Query: 3158 AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLETV 3210
V+ QL + L ++ EV E+ + G Q ++ EL +R+ +
Sbjct: 1493 VVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVTAL 1544
Query: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
L L +R +L+ L +++ ++ + L WL + K + L
Sbjct: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
S++ + QK + + + I GE+L + G+++ ++++L L ++W ++ +
Sbjct: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVTSR 1662
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
+ + L + + + + +V+ + WI + E P Q E L R KA LN
Sbjct: 1663 AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELN 1721
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LEEM 3448
++ R + + AA+++ N + + + + +N A++ ++ S L+E+
Sbjct: 1722 DI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL 1779
Query: 3449 TQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSNKN 3488
Q + Q+ + +E +++ K L+ D L + +
Sbjct: 1780 EQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1839
Query: 3489 LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3548
E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ + ++
Sbjct: 1840 REEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKCLD 1890
Query: 3549 SGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDVRL 3604
+E KL + + +++E+ +L +EL+ + A G D +E ++
Sbjct: 1891 D----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI 1946
Query: 3605 FLNK-------------------IHVLK----------LDIEASE------AECRH---- 3625
L+K IH ++ + +E S E H
Sbjct: 1947 QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQA 2006
Query: 3626 MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K +
Sbjct: 2007 LLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2062
Query: 3685 TAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFKMF 3714
T E EAL QW +++I NQ L + + F
Sbjct: 2063 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122
Query: 3715 QKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753
++ P Q ++ +N G+ +IQ + K D L+ +
Sbjct: 2123 LRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQEKL 2181
Query: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3813
+N RW + K+++ R +L+E +FQ L + WL + + + + P E +
Sbjct: 2182 GSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQ 2241
Query: 3814 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRWTE 3871
+K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W +
Sbjct: 2242 -LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2300
Query: 3872 ----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQTAK 3923
L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2301 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2360
Query: 3924 IQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------AEQ 3964
+Q+ I +A + D+E + K + + L L+S A+Q
Sbjct: 2361 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2420
Query: 3965 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEVLN 4011
L+ + ++ A ++ + + A+S + F E+ +
Sbjct: 2421 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2480
Query: 4012 WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE 4071
WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+ +
Sbjct: 2481 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2540
Query: 4072 EV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 4130
E +I ++++ I+ ++ ++ + L + + +T++ EE L + +L
Sbjct: 2541 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2600
Query: 4131 TSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 4190
+ T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2601 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 2660
Query: 4191 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----- 4245
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2661 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2720
Query: 4246 LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESLIQ 4303
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2721 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2780
Query: 4304 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 4363
++ + + + LE + + + +EL W++ +++ D +++Q
Sbjct: 2781 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2840
Query: 4364 QEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAENMY 4413
+ R + + +P I L+ L++L E E+ EE+ Q +
Sbjct: 2841 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2900
Query: 4414 AQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 4472
+ EEV L+ + +I E ++++ + E + L +LR +I +
Sbjct: 2901 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2960
Query: 4473 ECISDNKSATVELEK 4487
+ + D+ +E K
Sbjct: 2961 DLLIDSLQDHLEKVK 2975
Score = 204 bits (518), Expect = 3e-51
Identities = 414/2141 (19%), Positives = 854/2141 (39%), Gaps = 303/2141 (14%)
Query: 1804 LEHDEKLVSYLSLLRNIEMRTKQIQP----LELNLAELQDLLCQAKVLERELKDLTTLVS 1859
+EH +KL ++ LR I+ + ++ +++ L E L +++L+++LK LVS
Sbjct: 1033 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVS 1092
Query: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK 1919
+++ + + S + +A + A L+ L ++ W+ H V K
Sbjct: 1093 -DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD----HMCQQVYARKEA 1147
Query: 1920 V---LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER 1976
+ L + L+ L ++ W+ + + D L +++ + K+ ++
Sbjct: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQK 1206
Query: 1977 KAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQ 2036
+A++ L + I++ P + + L L ++Q + + +
Sbjct: 1207 EAKVKLLTESVNSVIAQ----APPVAQEALKKELETLTTNYQWLCTRLNGK--------- 1253
Query: 2037 QMEQEALVKTLQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQ------QDLSAL 2087
KTL++ H+ LE W+ + E L +TT+ +++S +
Sbjct: 1254 -------CKTLEEVWACWHELLSYLEKANKWLNEVEFKL-----KTTENIPGGAEEISEV 1301
Query: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
+ +L +D N+ A + D G M+E + E+L ++
Sbjct: 1302 LDSLENLMRHSEDNPNQIRILAQTLTD-GGVMDE-----------LINEELETFNSRWRE 1349
Query: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 2207
L EE QK LE+++ SA QETEKS + E+ ID L + Q+
Sbjct: 1350 LHEEAVRRQKLLEQSIQSA--QETEKS--LHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1405
Query: 2208 LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE------LLSQQQNF 2261
++ S + + +L+ + +A +++ Q ++ + + Q+ L + NF
Sbjct: 1406 AQKIQ--SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF 1463
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ---------- 2311
Q ++ LD+ +L E + ++Q++ + + + +L +S +E+K
Sbjct: 1464 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
Query: 2312 --VQTLQDELQKFLQD---------------------------------HKEFE---SWL 2333
VQ Q E K L + KE WL
Sbjct: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
++ EL P L S + + +++ K L+ +T G+ + +
Sbjct: 1584 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----L 1638
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWM 2450
GK+ + LV+DKL + A+ S R LN+LL Q H F + D + W+
Sbjct: 1639 GKKET----LVEDKLSLLNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI 1691
Query: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2510
+ LL ++ P Q++ K+L+ EL + + V+ + A ++M G
Sbjct: 1692 ----IQADTLLDESEKKKP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-- 1742
Query: 2511 APDH-RHVQETTDSILSH-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSI 2563
DH R + E S L+H F ++S+ + ++S+ K + Q Q + E LE+ +Q
Sbjct: 1743 --DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1800
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTT 2622
+++ K ++ + G ++E L L+Q I ++ E ++ + + A
Sbjct: 1801 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1860
Query: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2682
+ + K E+S ++ Q ++ + L + +++ + LAS
Sbjct: 1861 RSQRRKKALEISHQWYQ---------------------YKRQADDLLKCLDDIEKKLASL 1899
Query: 2683 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
+P + ++I+E++ E++ ++E L+ + LS G A+ + +
Sbjct: 1900 PEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV------------E 1942
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
T++Q + + RE ++ Q + F + + T ++ P E S +I
Sbjct: 1943 PTQIQLSKRWREIESKFAQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEIT 2001
Query: 2803 HLKSLL---------DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS 2853
H+ L D +K E++ + SL+N+ DS ++ + + S
Sbjct: 2002 HVSQALLEVEQLLNAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHS 2053
Query: 2854 SVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVL 2913
+ T + ++Q +S ++ ++EK+ + +RQ + + H +
Sbjct: 2054 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 2113
Query: 2914 QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---L 2970
QWL E+ L+ P E K K +L EL+ + Q V L +
Sbjct: 2114 QWLTEAEQFLRKTQI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEI 2165
Query: 2971 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 3030
+ + +A ++ LN RW+ + R+++LEE + L+ FQ ++ WL E
Sbjct: 2166 IQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE 2225
Query: 3031 KELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
+ + + PL L + +QV+ +++E R+ +QLNE +L
Sbjct: 2226 ADNIASI--PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE 2283
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV- 3148
+++ +L+ N +W++++ L + +I+ I Q ++ L+DL E++ + LS
Sbjct: 2284 QDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2343
Query: 3149 --QSAISTQPE------------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLI 3194
Q I QP AV+ + + EI S + L E Q + +L L
Sbjct: 2344 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2403
Query: 3195 GEQYLKDELKKRL-------------------ETVALPLQGL--EDLAADRI---NRLQA 3230
E + L + L +TV L Q + ++ A ++ + L
Sbjct: 2404 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLML 2463
Query: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
+ + F + + EL WL + LE + + + + + L Q
Sbjct: 2464 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 2523
Query: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
E ++ ++L E + + +++ ++N W+E+ + +R+ +L + ++ + ++
Sbjct: 2524 EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 2583
Query: 3351 HVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407
E+ + +AK+ + T+D +Q + +K + ++ + ++ +++ N A
Sbjct: 2584 AKEEAEQVLGQARAKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLAL 2641
Query: 3408 ILINSSEADED-GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIE 3463
L+ AD+ + IN + ++ + + + +LEE + L++F E F
Sbjct: 2642 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 2701
Query: 3464 KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVED 3519
+ E + L+ +K +++L Q + LQ +E D N +Q ++
Sbjct: 2702 TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS 2761
Query: 3520 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3579
DA L + + ++ E++++ + +E + + H ++E+ L D
Sbjct: 2762 LEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2821
Query: 3580 DELDGMGAIGRDTDSLQSQ---------------------IEDVRLFLNKIHVLKLDIEA 3618
DEL IG D ++Q Q +E VR+FL + + L E
Sbjct: 2822 DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EK 2879
Query: 3619 SEAECRHMLEEEGTLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKL 3677
E R + EE ++ L+++ E +N + KL Q +++ TL R+++
Sbjct: 2880 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2939
Query: 3678 KGLNDATTAAEEAEALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
L+ AE + VG ++ + L K + E + PL+ + VN L + L
Sbjct: 2940 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL 2998
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777
+ G L +E++N RW L V R+ QL EA
Sbjct: 2999 -TTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHEA 3037
Score = 194 bits (492), Expect = 3e-48
Identities = 469/2759 (16%), Positives = 1097/2759 (39%), Gaps = 318/2759 (11%)
Query: 1807 DEKLVSYLSLLRNIEMRTKQIQ--PLELNLAELQDLLCQAKVLERELKDLTTLVSQELEC 1864
++KL L E RT++++ PL +L +L+ + Q KVL+ +L+ V+
Sbjct: 450 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
Query: 1865 VNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQH 1924
V + S A ALE+ K L +++ R + Q+ +L +
Sbjct: 510 VVVVDESSGDHATA----ALEEQLKVLGDRWANICRWTEDRWVLLQD--------ILLKW 557
Query: 1925 TQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA 1984
+L AW+ K +N + D + + LQ+ LK + ++K + L
Sbjct: 558 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 617
Query: 1985 FDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV 2044
Q +S Q+ L + LE++ AQ+ +A+
Sbjct: 618 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS-----------QAVT 666
Query: 2045 KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 2104
T Q + + + + V E+ L H Q++L + + +I+ R
Sbjct: 667 TT---QPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDSEIRKR 719
Query: 2105 A----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQEETRV 2154
T + + E ++ + + +E + L+EK++ + E++ LQ+ +R
Sbjct: 720 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 779
Query: 2155 AQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLLTNLPG 2210
AQ +E+ V + ++ K +A+++L E + + L+W+ + L
Sbjct: 780 AQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQ 837
Query: 2211 MEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270
+EQ++ + + T P + Q ++ K L Q I +
Sbjct: 838 LEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERLKIQSI 891
Query: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKE 2328
L + G L + + +A K++QT+ D L ++ +
Sbjct: 892 ALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSA 946
Query: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
+W+++SE +L + E + L + + + L +++ + +++
Sbjct: 947 IRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM---- 1002
Query: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
K PSEI + + ++ R+ L S+ L + + + QN +L+
Sbjct: 1003 ----SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 1058
Query: 2449 WMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
WM A V+ L + D +L++QL KQ + +++ Q L V +I
Sbjct: 1059 WM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
Query: 2507 EGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2565
+ E P+ ET + + + + + R L+ + ++ S+Q+ L + + + +
Sbjct: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
Query: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1172 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1231
Query: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRMLASGNQ 2684
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++ + N
Sbjct: 1232 LKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENI 1291
Query: 2685 PD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1292 PGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LETFNSR 1346
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
+ EL + R+K L+ + +ETE S+ + S++ ++KQ+
Sbjct: 1347 WRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--IDKQLA 1390
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+ D A ++I TS E + +E +QGK +
Sbjct: 1391 AYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA--------------QR 1435
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
+ Q + DV++K+ L ++ + + L + + E L LE+K
Sbjct: 1436 VLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALETKS-- 1488
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2982
+ E V++Q L + +++ V + ++ ++ EN
Sbjct: 1489 ----------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKKQTENP 1534
Query: 2983 KKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
K++ E + + E+ R++QLE+ + + L WL ++ +
Sbjct: 1535 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1594
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
+ P+ L+++ + KE E ++ + + E + + T G + V+ +L
Sbjct: 1595 AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVEDKLSL 1651
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N W+ +T S+ ++ + +YQ+ ++ + V + + + + + E
Sbjct: 1652 LNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKK 1704
Query: 3160 KQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217
K Q +E ++++L + +V + L G D +K +E L
Sbjct: 1705 KPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQISELNHR 1759
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ RI +A++ ++ +Q +++ L+ P+ A+++ Q + E
Sbjct: 1760 FAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGVNLKEE 1806
Query: 3278 EFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 3336
+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L + R+
Sbjct: 1807 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1866
Query: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVE 3393
+ + + +Y+ +DL+ ++D + K++ L D +++ L + K LN V
Sbjct: 1867 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1926
Query: 3394 KRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL--EEMT 3449
++ L +A + + + I + A + A ++ +T + E+M
Sbjct: 1927 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1986
Query: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP----- 3504
+ ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1987 LEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQS 2044
Query: 3505 --QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEG 3560
++D + + ++ A + ++ Q ++Q +F +V + + +E
Sbjct: 2045 SGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEK 2101
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEA 3618
+FH ++ +F+Q ++ I + + + + +++++ + + + + A
Sbjct: 2102 WRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2160
Query: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGRVEDFY 3674
+ E ++++ D L+ +L +LN + C +L++R K +EQ + + +F
Sbjct: 2161 TGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQ 2213
Query: 3675 RKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVN 3730
R L N+ EEA+ + + G E ++ ++L K+ +E PL+ L+Q+N
Sbjct: 2214 RDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLN 2267
Query: 3731 GLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+ + LE
Sbjct: 2268 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2327
Query: 3790 PL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
L L WL+ + P+ E +QE ++ + ++ V+ + ++
Sbjct: 2328 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVEEILSK 2381
Query: 3843 GGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------------ 3887
G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2382 GQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2439
Query: 3888 -----VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEPVGTQT 3921
V+ K+ F+ ++D+LS+ ++ + + +
Sbjct: 2440 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2499
Query: 3922 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSE 3980
I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q ++ E
Sbjct: 2500 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2559
Query: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADH 4040
+Q+ + L++ L ++ + E + E L + KL S + D + ++ +
Sbjct: 2560 VQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITET 2619
Query: 4041 LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 4100
L +++ + NVD A LL+ + ++ + + I + I S+
Sbjct: 2620 KQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAA 2679
Query: 4101 LEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQKELKK 4154
LE+ +L +F E+ WL E E ++ + + + ++ ++L+
Sbjct: 2680 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2739
Query: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTIGQRVD 4208
E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2740 EIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2794
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF------- 4261
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2795 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2854
Query: 4262 ------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAI 4308
+++ +R + +++L+ E+ + T +L+++ E + ++E +
Sbjct: 2855 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2914
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEM 4367
+L +++ +++ + + E +EL + + + P + + L+ E++
Sbjct: 2915 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2974
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
+ LR IA K ++ + + QL +L+P +E+ + + + +++ VRQ
Sbjct: 2975 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3033
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3831
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
Query: 3832 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3889
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 445
Query: 3890 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 446 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
+ + + L E++ L R++ I + LL L + E++
Sbjct: 506 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 565
Query: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 4066
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 566 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 625
Query: 4067 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 4113
+ V E D + + T S+A+ T + + T ++
Sbjct: 626 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 685
Query: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 4172
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 686 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 739
Query: 4173 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 4215
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 740 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 799
Query: 4216 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 4259
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 800 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 859
Query: 4260 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 4312
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 860 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
Query: 4313 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
Query: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 4426
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 978 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1027
Query: 4427 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 4472
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 1028 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1081
Query: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 1082 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1137
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197
Query: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257
Query: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4708
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
Query: 4709 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4768
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1318 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
Query: 4769 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1424
Query: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1425 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1470
Query: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4948
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1471 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1529
Query: 4949 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 5008
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1530 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
Query: 5009 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 5068
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1590 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1648
Query: 5069 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 5099
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1649 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1708
Query: 5100 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 5129
+ K+L L D +DS + ++N D
Sbjct: 1709 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1768
Query: 5130 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1769 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1828
Query: 5188 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 5233
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1829 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1887
Query: 5234 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 5287
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1888 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1945
Query: 5288 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 5347
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1946 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2002
Query: 5348 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 2003 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2062
Query: 5396 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 5444
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 2063 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122
Query: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5504
L + IP+N + K ++ +++E+ V +T
Sbjct: 2123 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2159
Query: 5505 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5564
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2160 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2212
Query: 5565 KEFANFDFDVW 5575
+ N +F +W
Sbjct: 2213 QRDLN-EFVLW 2222
Score = 91.3 bits (225), Expect = 3e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 5087 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 5146
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 327 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 386
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 387 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Query: 5206 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 5263
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 447 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
Query: 5264 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 5322
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 564
Query: 5323 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 5380
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 565 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 623
Query: 5381 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 5437
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 624 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 683
Query: 5438 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 5494
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 684 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 737
Query: 5495 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5554
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 738 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 793
Query: 5555 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5614
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 794 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 849
Query: 5615 LASKFPTTKLEMTAV 5629
PTT E TA+
Sbjct: 850 --KIQPTTPSEPTAI 862
>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
Length = 3562
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 261 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 320
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2832
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 321 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 372
Query: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2892
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 373 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 428
Query: 2893 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2950
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 429 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 488
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2991
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 489 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 548
Query: 2992 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 3024
T+ TV ++RQ+ + ++L
Sbjct: 549 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 608
Query: 3025 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 3083
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 609 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 668
Query: 3084 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 669 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 727
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 3202
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 728 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 766
Query: 3203 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 3241
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 767 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 824
Query: 3242 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 3300
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 825 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 882
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 883 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 942
Query: 3361 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 3418
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 943 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1002
Query: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 3477
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1003 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1062
Query: 3478 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1063 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1121
Query: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1122 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1174
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3654
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1175 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1233
Query: 3655 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3714
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1234 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1273
Query: 3715 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3772
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1274 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1320
Query: 3773 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1441 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1500
Query: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1501 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1559
Query: 4001 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 4058
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1560 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1612
Query: 4059 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 4116
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1613 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1672
Query: 4117 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 4167
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1673 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1732
Query: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 4222
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1733 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1790
Query: 4223 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1791 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1842
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
F Q ++E+T ++ + + + + + + +S
Sbjct: 1843 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 1887
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 4398
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 1888 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 1947
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 4458
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 1948 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2004
Query: 4459 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4516
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2005 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2057
Query: 4517 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4576
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2058 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2116
Query: 4577 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4634
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2117 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2175
Query: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4694
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2176 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2232
Query: 4695 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4739
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2233 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2292
Query: 4740 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4772
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2293 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2352
Query: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2353 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2412
Query: 4833 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2413 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2472
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2473 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2531
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2532 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2591
Query: 5012 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 5064
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2592 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2651
Query: 5065 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2652 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2711
Query: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 5170
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2712 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2771
Query: 5171 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 5225
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2772 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2831
Query: 5226 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 5283
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2832 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 2890
Query: 5284 KGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
L++L+TRW L V+ + R+ Q
Sbjct: 2891 LSTLEDLNTRWKL---LQVAVEDRVRQ 2914
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2772 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2828
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 205 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 259
Query: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2888
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 260 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 315
Query: 2889 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2948
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 316 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 373
Query: 2949 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2998
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 374 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 433
Query: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 3057
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 434 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 482
Query: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 3117
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 483 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 541
Query: 3118 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 3171
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 542 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600
Query: 3172 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 3213
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 601 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660
Query: 3214 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 3258
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 661 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720
Query: 3259 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 721 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 777
Query: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 3364
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 778 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 837
Query: 3365 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 3421
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 838 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 896
Query: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 3480
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 897 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 956
Query: 3481 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3540
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 957 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1015
Query: 3541 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3600
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1016 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1075
Query: 3601 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3660
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1076 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1135
Query: 3661 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
+ LE + L+ N E + E I++ L + + D
Sbjct: 1136 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1195
Query: 3721 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1196 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1246
Query: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3839
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1247 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1304
Query: 3840 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3897
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1305 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1344
Query: 3898 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1345 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1404
Query: 3954 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 4013
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464
Query: 4014 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1465 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1523
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1524 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1583
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1584 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1638
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 4253
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1639 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1692
Query: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1693 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1743
Query: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 4373
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1744 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1802
Query: 4374 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 4419
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1803 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 4420 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 4479
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 1916
Query: 4480 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4539
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 1972
Query: 4540 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4596
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 1973 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2024
Query: 4597 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4653
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2025 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2084
Query: 4654 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4713
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2085 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2143
Query: 4714 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2144 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2203
Query: 4773 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4823
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2204 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2255
Query: 4824 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4880
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2256 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2313
Query: 4881 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2314 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2373
Query: 4931 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4962
E N+++ K + + L S ++T +
Sbjct: 2374 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2433
Query: 4963 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 5022
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2434 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2493
Query: 5023 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 5082
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2494 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2553
Query: 5083 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 5136
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2554 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2613
Query: 5137 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 5196
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2614 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2673
Query: 5197 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 5256
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2674 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2733
Query: 5257 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 5295
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2734 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2793
Query: 5296 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 5355
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2794 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2847
Query: 5356 HKEFMKKVEEKRVDV 5370
++ ++KV+ R ++
Sbjct: 2848 LQDHLEKVKALRGEI 2862
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2834 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2890
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 154 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 213
Query: 2891 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2950
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 214 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 264
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 3007
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 265 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 322
Query: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 3065
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 323 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 380
Query: 3066 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 3125
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 381 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 427
Query: 3126 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 3185
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 428 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 472
Query: 3186 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 3245
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 473 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 524
Query: 3246 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 3304
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 525 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 582
Query: 3305 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 3364
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 583 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 617
Query: 3365 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 3419
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 618 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 677
Query: 3420 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 3479
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 678 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 736
Query: 3480 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3535
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 737 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 795
Query: 3536 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3590
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 796 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 846
Query: 3591 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3649
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 847 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 906
Query: 3650 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3709
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 907 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 966
Query: 3710 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3769
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 967 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1024
Query: 3770 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3826
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1025 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1081
Query: 3827 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3886
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1082 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1141
Query: 3887 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1142 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1198
Query: 3947 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 4006
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1199 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1255
Query: 4007 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 4065
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1256 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1313
Query: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1314 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1358
Query: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1479 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1527
Query: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 4362
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1528 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587
Query: 4363 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 4416
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1588 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1644
Query: 4417 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 4475
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1645 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1694
Query: 4476 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4535
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1695 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 4536 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4595
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1742 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1800
Query: 4596 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4650
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1801 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 4651 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4700
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 1915
Query: 4701 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4760
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 1916 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 1974
Query: 4761 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 1975 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2031
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2032 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2091
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2092 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2150
Query: 4940 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4998
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2151 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2210
Query: 4999 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 5051
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2211 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2264
Query: 5052 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 5081
L +K +K L + S W+ V +
Sbjct: 2265 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2322
Query: 5082 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2323 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2382
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2383 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2442
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2443 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2502
Query: 5251 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 5309
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2503 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562
Query: 5310 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 5367
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2563 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2619
Query: 5368 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2620 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2679
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2680 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2737
Query: 5480 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5537
+ +E E+ G K +P PP + + + +++
Sbjct: 2738 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2789
Query: 5538 ARWQQVWLLALERQRKLNDALDRLEELKE 5566
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2790 TEWEKLNLHSADWQRKIDETLERLQELQE 2818
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 220 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 277
Query: 2498 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2557
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 278 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 335
Query: 2558 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 336 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 395
Query: 2616 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2671
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 396 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 455
Query: 2672 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2731
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 456 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 515
Query: 2732 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2778
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 516 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 573
Query: 2779 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2828
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 574 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 633
Query: 2829 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2879
+L ++ A + Q + S V V + K +E +N
Sbjct: 634 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 687
Query: 2880 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 688 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 738
Query: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2990
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 792
Query: 2991 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 3048
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852
Query: 3049 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 3107
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 853 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 909
Query: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 3167
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 910 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 969
Query: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 3223
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 970 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020
Query: 3224 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 3279
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080
Query: 3280 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 3339
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1139
Query: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 3398
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1140 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1199
Query: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1200 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1255
Query: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1256 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1311
Query: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3578
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1312 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1358
Query: 3579 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1359 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1418
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3698
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1419 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1478
Query: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3758
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1479 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1535
Query: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3816
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1536 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1595
Query: 3817 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3872
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1596 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1648
Query: 3873 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3930
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1649 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1685
Query: 3931 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3988
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1686 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1745
Query: 3989 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 4041
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1746 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1800
Query: 4042 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 4096
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1801 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857
Query: 4097 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 4151
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1858 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 1917
Query: 4152 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 1918 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 1977
Query: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 4270
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 1978 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2034
Query: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2035 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2094
Query: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2095 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2153
Query: 4391 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2154 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2210
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2211 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2264
Query: 4508 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2265 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2312
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
SP +++ Q V ET K E
Sbjct: 2313 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2337
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
+ S+ A + N+ W E + DWL + + +
Sbjct: 2338 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2376
Query: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2377 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2436
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2437 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2496
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2497 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2556
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4920
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2557 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2616
Query: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2617 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2676
Query: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2677 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2736
Query: 5041 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 5080
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2737 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2796
Query: 5081 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2797 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2853
Query: 5141 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 5198
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2854 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 2913
Query: 5199 KLEEA 5203
+L EA
Sbjct: 2914 QLHEA 2918
Score = 244 bits (622), Expect = 2e-63
Identities = 502/2853 (17%), Positives = 1100/2853 (38%), Gaps = 303/2853 (10%)
Query: 2296 EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355
+ + +SL +SE L + QT +E+ SWL +E L+ + + E +
Sbjct: 205 KSFGSSLMESEVNLDRYQTALEEVL----------SWLLSAEDTLQAQGEISNDVEVVKD 254
Query: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415
+ D+ +H+G + + G K++ GK + V++++ R+
Sbjct: 255 QFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQEQMNLLNSRW 308
Query: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475
L S+L+ +L L W+ E K+ + + D L+ Q
Sbjct: 309 ECLRVASMEKQSNLHRVLMDLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 366
Query: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ----------------- 2518
+ K LQE+L + QV V L + + E G+ A Q
Sbjct: 367 VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 426
Query: 2519 --ETTDSILSHFQSL-------SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569
IL +Q L S L+E+ + K Q + S LQ + ++ +
Sbjct: 427 RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 486
Query: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2629
LE K+ S +++ L + +K K + ++ L+ ++ + +TA + Q
Sbjct: 487 LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 546
Query: 2630 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ----P 2685
+ ++ ++ +++L +H +L K R + ++
Sbjct: 547 TTTQPSLTQTTVMETVTTVTTREQIL-----VKHAQEELPPPPPQKKRQITVDSEIRKRL 601
Query: 2686 DQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL--DLCQHQDRVQNLRKDF 2743
D DIT I ++ + + E ++L A+ + + ++Q+ +
Sbjct: 602 DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 661
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEH 2803
L + + +A S ++ ++ F + L E + ++ +Q+E
Sbjct: 662 QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 721
Query: 2804 LKSLLDDWAS-KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS-SVGSVNGY 2861
+ + ++W + T E + L+ D + + P + + S+
Sbjct: 722 MTTTAENWLKIQPTTPSEPTAIKSQLK------ICKDEVNRLSGLQPQIERLKIQSIALK 775
Query: 2862 HTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV-HKEANSVLQ-WLESK 2919
+ + D ++++ + R++ LQ I + + + ++E S ++ W++
Sbjct: 776 EKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS 835
Query: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEA 2979
E L S T E ++ + +A + L++ + + + + P S+ +
Sbjct: 836 ETKLSI--PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 892
Query: 2980 ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
++ EE+ RW++ + V ++LEE + L Q L+ W+ E ++ +
Sbjct: 893 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 952
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
P D +L Q +Q + ++ + + + +NE Q I S+++ EL+
Sbjct: 953 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKE 1010
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N +W + ++ +R + + K+ Q+ L ++ E + + + P+ +
Sbjct: 1011 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1070
Query: 3160 KQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE--QYLKDELKKRLETVALPLQGL 3217
++ +EE + + +Q + +VK L + ++ +I + ++ LKK LET+ Q L
Sbjct: 1071 QKAVEEMKRAKEEAQQKEAKVK---LLTESVNSVIAQAPPVAQEALKKELETLTTNYQWL 1127
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ L+ A + ++ WL++ + + I E + L E
Sbjct: 1128 CTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLE 1187
Query: 3278 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 3337
+ + ++ G + +L + W EL ++ RQ
Sbjct: 1188 NLMRHSEDNPNQIRILAQ------TLTDGGVMDELINEELETFNSRWRELHEEAVRRQKL 1241
Query: 3338 LKDCMQKAQKYQWHV-----------EDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSK 3386
L+ +Q AQ+ + + + L +I D K+ ++ + +++S L +
Sbjct: 1242 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD---KVDAAQMPQEAQKIQSDLTSHE 1298
Query: 3387 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRD--EKAGINQNMDAVTEELQAKTGS 3444
L E++K E AA +++ + + ++D K + Q + LQ
Sbjct: 1299 ISLEEMKKHNQGKE----AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1354
Query: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504
L+E+ L + K++E++V Q+ N + ++ EV +E
Sbjct: 1355 LDEVKMHLPALET--KSVEQEV--------------VQSQLNHCVNLYKSLSEVKSEVEM 1398
Query: 3505 QVDYLRNFTQGLVEDAPDGSD---ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
+ R Q + P D + LH E+ + E KQ++ C+ + K+
Sbjct: 1399 VIKTGRQIVQKKQTENPKELDERVTALKLHYNELG-AKVTERKQQLEK-CLKLSRKMRK- 1455
Query: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI-----EDVRLFLNKIHVLKLDI 3616
+ + LA D EL A+ +L S++ + K+H LK
Sbjct: 1456 -----EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH-LKSIT 1509
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL---GRVEDF 3673
E EA + +L ++ TL ++ +L LN +T R +E L L L +E F
Sbjct: 1510 EVGEA-LKTVLGKKETL----VEDKLSLLNSNWIAVTSRA---EEWLNLLLEYQKHMETF 1561
Query: 3674 YRKL----KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3729
+ + K + A T +E+E + QQ D K +++ ++ K+
Sbjct: 1562 DQNVDHITKWIIQADTLLDESEKKK----------PQQKEDVLKRLKAELNDIRPKVDST 1611
Query: 3730 NGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
L+ + G C + +E + E+N R+ ++ ++ GK L+
Sbjct: 1612 RDQAANLMANRGDHCR-KLVEPQISELNHRFAAISHRI------------KTGKASIPLK 1658
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
L + +D ++L+ +P AE + ++E+ + + +D + TV L G + Q
Sbjct: 1659 ELEQFNSDIQKLL---EPLEAEIQ-QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1714
Query: 3850 -AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908
+ RE+I + + L+++ L + R+K+ +I Q+ A+ + L E
Sbjct: 1715 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1774
Query: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
KKLA S P KI++ + L++ E QA + + +++ Q LS
Sbjct: 1775 KKLA-SLPEPRDERKIKE---IDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS 1830
Query: 3969 EKIDSLQARYSEI------QDRCCRKAALL----DQALSNARL---FGEDEVEVLNWLAE 4015
++ +++++++ Q R+ ++ D L + + + + V L E
Sbjct: 1831 KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE 1890
Query: 4016 VEDKLSS--VFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
VE L++ + KDF+ L +Q + + + +D A L+ T E
Sbjct: 1891 VEQLLNAPDLCAKDFED--LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 1948
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
+ +QE L + ++ + +++ + +F + WL E E+ L +
Sbjct: 1949 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT- 2007
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
Q P + +++ KEL+ + + + V+ T+N +++ L + + N
Sbjct: 2008 -QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLN 2066
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLE---QDQ 4250
+++ V + R ++ ++++ + + W+ E + I LE + Q
Sbjct: 2067 LRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN----IASIPLEPGKEQQ 2122
Query: 4251 TTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAI 4308
+L+ K ++ + + +L + E++ L+ K + Q+ +
Sbjct: 2123 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKV 2182
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE-EM 4367
S E+ +E + Q + E+L + ++ + + + Q Q+ ++
Sbjct: 2183 SRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 2242
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK---EEVRQR- 4423
++ ++ +P ++++L G L + P + V+ K + + + + +E+R +
Sbjct: 2243 QETEIAVQAKQPDVEEILSKGQHLYKEKPAT-QPVKRKLEDLSSEWKAVNRLLQELRAKQ 2301
Query: 4424 ------------------ALALDEAVSQSTQITEFHDKIEPMLET--------------- 4450
L V++ T I++ MLE
Sbjct: 2302 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2361
Query: 4451 -LENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4509
L L ++ ++ +++ I E I K+ +LE+ +P E L + L ++
Sbjct: 2362 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2421
Query: 4510 DKDLAAKEIQDKLDQMVFFWEDIKARAEER----------EIKFLDVLELAEKFWYDMAA 4559
+ A I D+++++ W++++ + R ++L+ E AE+ A
Sbjct: 2422 E---ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2478
Query: 4560 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4619
L + K+ V ++ + + + + +T + + L L+ +R AD
Sbjct: 2479 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD----- 2531
Query: 4620 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD----- 4674
+T K V + +N +W +++K ER LE+ + Q+ L+ WL
Sbjct: 2532 -DTRK--VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2588
Query: 4675 -NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4733
N + + D VK+ + + ++ + E+ L+ + +L+ D
Sbjct: 2589 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2648
Query: 4734 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4793
+++ L + W L +K + + LE + + +L+EL+ WL ++ L Q
Sbjct: 2649 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2708
Query: 4794 RPISGDPKVIEVELAKHHVLKNDVLAHQ----ATVETVN-------KAGNELL------- 4835
PI GD ++ + H K ++ + +T+ETV G E L
Sbjct: 2709 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2768
Query: 4836 --ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELT 4893
E A + LR + E +N WE + + + ++++ TL++ Q ++ L+L
Sbjct: 2769 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2828
Query: 4894 RMESQLSASKPTGG-LPETAREQLDTHMELYSQLKAKEETYNQLLDKGR-LMLLSRDDSG 4951
+ E + +P G L ++ ++ L+ L ++ +E + + D R L L S
Sbjct: 2829 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 2888
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
T + L +W ++ +E+R +L EA
Sbjct: 2889 YNLSTLED---LNTRWKLLQVAVEDRVRQLHEA 2918
Score = 226 bits (575), Expect = 7e-58
Identities = 493/2775 (17%), Positives = 1066/2775 (38%), Gaps = 371/2775 (13%)
Query: 1952 SEIDVDSLNLCLQQY-------EDLKQPMAERKAQLDALAFDIQFFISE-HAQDLSPQQN 2003
SE+++D L++ ED Q E ++ + QF E + DL+ Q
Sbjct: 214 SEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD--QFHTHEGYMMDLTAHQG 271
Query: 2004 R--QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC------- 2054
R +L+L ++L + + + E +V L + V +++KQ N
Sbjct: 272 RVGNILQLGSKLIGTGK-LSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 330
Query: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSF 2108
+Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 331 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 390
Query: 2109 ATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVAQK 2157
VV + G +EE L R R L +++ L EE +
Sbjct: 391 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 450
Query: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 451 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLLST 507
Query: 2218 SLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 2276
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 508 LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT---- 563
Query: 2277 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWLER 2335
+T EQ +++ E L + K+ T+ E++K L D E SW+ R
Sbjct: 564 -TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWITR 614
Query: 2336 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 2395
SE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 615 SEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 665
Query: 2396 EPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWMQA 2452
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 666 EQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTT 725
Query: 2453 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2512
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 726 AENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ--- 779
Query: 2513 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQNL 2570
+ + +HF+ + + R LQ QE++ ++ + + E L
Sbjct: 780 GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 839
Query: 2571 EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKL 2630
Q+S ++++ L L+ + Q+S L V + A S + Q +
Sbjct: 840 SIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEF 899
Query: 2631 AEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2683
E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 900 EEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD-- 957
Query: 2684 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDF 2743
+ + +Q + L +++ Q +L+++ ++ + + + ++ L +
Sbjct: 958 --SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1015
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIE 2802
+ + V R++ E+ +K + +W+ + E + + EL+K +E
Sbjct: 1016 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1075
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+K ++ K V+ + T N ++ P +Q
Sbjct: 1076 EMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ--------------------- 1110
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1111 -----EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1165
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQEAE 2980
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1166 LKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE--- 1220
Query: 2981 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 3040
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1221 -----LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA 1275
Query: 3041 LSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 3097
+D + + Q++Q L E ++H Q EAAQ +L+ QK+L
Sbjct: 1276 DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQKKL 1328
Query: 3098 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE 3157
Q ++ K+ + K +++ LQ+ + V L S + E
Sbjct: 1329 QDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQE 1373
Query: 3158 AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLETV 3210
V+ QL + L ++ EV E+ + G Q ++ EL +R+ +
Sbjct: 1374 VVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVTAL 1425
Query: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
L L +R +L+ L +++ ++ + L WL + K + L
Sbjct: 1426 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1485
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
S++ + QK + + + I GE+L + G+++ ++++L L ++W ++ +
Sbjct: 1486 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVTSR 1543
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
+ + L + + + + +V+ + WI + E P Q E L R KA LN
Sbjct: 1544 AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELN 1602
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LEEM 3448
++ R + + AA+++ N + + + + +N A++ ++ S L+E+
Sbjct: 1603 DI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL 1660
Query: 3449 TQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSNKN 3488
Q + Q+ + +E +++ K L+ D L + +
Sbjct: 1661 EQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1720
Query: 3489 LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3548
E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ + ++
Sbjct: 1721 REEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKCLD 1771
Query: 3549 SGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDVRL 3604
+E KL + + +++E+ +L +EL+ + A G D +E ++
Sbjct: 1772 D----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI 1827
Query: 3605 FLNK-------------------IHVLK----------LDIEASE------AECRH---- 3625
L+K IH ++ + +E S E H
Sbjct: 1828 QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQA 1887
Query: 3626 MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K +
Sbjct: 1888 LLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 1943
Query: 3685 TAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFKMF 3714
T E EAL QW +++I NQ L + + F
Sbjct: 1944 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2003
Query: 3715 QKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753
++ P Q ++ +N G+ +IQ + K D L+ +
Sbjct: 2004 LRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQEKL 2062
Query: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3813
+N RW + K+++ R +L+E +FQ L + WL + + + + P E +
Sbjct: 2063 GSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQ 2122
Query: 3814 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRWTE 3871
+K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W +
Sbjct: 2123 -LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2181
Query: 3872 ----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQTAK 3923
L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2182 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2241
Query: 3924 IQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------AEQ 3964
+Q+ I +A + D+E + K + + L L+S A+Q
Sbjct: 2242 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2301
Query: 3965 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEVLN 4011
L+ + ++ A ++ + + A+S + F E+ +
Sbjct: 2302 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2361
Query: 4012 WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE 4071
WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+ +
Sbjct: 2362 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2421
Query: 4072 EV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 4130
E +I ++++ I+ ++ ++ + L + + +T++ EE L + +L
Sbjct: 2422 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2481
Query: 4131 TSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 4190
+ T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2482 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 2541
Query: 4191 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----- 4245
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2542 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2601
Query: 4246 LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESLIQ 4303
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2602 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2661
Query: 4304 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 4363
++ + + + LE + + + +EL W++ +++ D +++Q
Sbjct: 2662 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2721
Query: 4364 QEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAENMY 4413
+ R + + +P I L+ L++L E E+ EE+ Q +
Sbjct: 2722 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2781
Query: 4414 AQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 4472
+ EEV L+ + +I E ++++ + E + L +LR +I +
Sbjct: 2782 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2841
Query: 4473 ECISDNKSATVELEK 4487
+ + D+ +E K
Sbjct: 2842 DLLIDSLQDHLEKVK 2856
Score = 204 bits (518), Expect = 3e-51
Identities = 414/2141 (19%), Positives = 854/2141 (39%), Gaps = 303/2141 (14%)
Query: 1804 LEHDEKLVSYLSLLRNIEMRTKQIQP----LELNLAELQDLLCQAKVLERELKDLTTLVS 1859
+EH +KL ++ LR I+ + ++ +++ L E L +++L+++LK LVS
Sbjct: 914 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVS 973
Query: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK 1919
+++ + + S + +A + A L+ L ++ W+ H V K
Sbjct: 974 -DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD----HMCQQVYARKEA 1028
Query: 1920 V---LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER 1976
+ L + L+ L ++ W+ + + D L +++ + K+ ++
Sbjct: 1029 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQK 1087
Query: 1977 KAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQ 2036
+A++ L + I++ P + + L L ++Q + + +
Sbjct: 1088 EAKVKLLTESVNSVIAQ----APPVAQEALKKELETLTTNYQWLCTRLNGK--------- 1134
Query: 2037 QMEQEALVKTLQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQ------QDLSAL 2087
KTL++ H+ LE W+ + E L +TT+ +++S +
Sbjct: 1135 -------CKTLEEVWACWHELLSYLEKANKWLNEVEFKL-----KTTENIPGGAEEISEV 1182
Query: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
+ +L +D N+ A + D G M+E + E+L ++
Sbjct: 1183 LDSLENLMRHSEDNPNQIRILAQTLTD-GGVMDE-----------LINEELETFNSRWRE 1230
Query: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 2207
L EE QK LE+++ SA QETEKS + E+ ID L + Q+
Sbjct: 1231 LHEEAVRRQKLLEQSIQSA--QETEKS--LHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1286
Query: 2208 LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE------LLSQQQNF 2261
++ S + + +L+ + +A +++ Q ++ + + Q+ L + NF
Sbjct: 1287 AQKIQ--SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF 1344
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ---------- 2311
Q ++ LD+ +L E + ++Q++ + + + +L +S +E+K
Sbjct: 1345 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1404
Query: 2312 --VQTLQDELQKFLQD---------------------------------HKEFE---SWL 2333
VQ Q E K L + KE WL
Sbjct: 1405 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1464
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
++ EL P L S + + +++ K L+ +T G+ + +
Sbjct: 1465 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----L 1519
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWM 2450
GK+ + LV+DKL + A+ S R LN+LL Q H F + D + W+
Sbjct: 1520 GKKET----LVEDKLSLLNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI 1572
Query: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2510
+ LL ++ P Q++ K+L+ EL + + V+ + A ++M G
Sbjct: 1573 ----IQADTLLDESEKKKP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-- 1623
Query: 2511 APDH-RHVQETTDSILSH-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSI 2563
DH R + E S L+H F ++S+ + ++S+ K + Q Q + E LE+ +Q
Sbjct: 1624 --DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1681
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTT 2622
+++ K ++ + G ++E L L+Q I ++ E ++ + + A
Sbjct: 1682 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2682
+ + K E+S ++ Q ++ + L + +++ + LAS
Sbjct: 1742 RSQRRKKALEISHQWYQ---------------------YKRQADDLLKCLDDIEKKLASL 1780
Query: 2683 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
+P + ++I+E++ E++ ++E L+ + LS G A+ + +
Sbjct: 1781 PEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV------------E 1823
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
T++Q + + RE ++ Q + F + + T ++ P E S +I
Sbjct: 1824 PTQIQLSKRWREIESKFAQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEIT 1882
Query: 2803 HLKSLL---------DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS 2853
H+ L D +K E++ + SL+N+ DS ++ + + S
Sbjct: 1883 HVSQALLEVEQLLNAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHS 1934
Query: 2854 SVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVL 2913
+ T + ++Q +S ++ ++EK+ + +RQ + + H +
Sbjct: 1935 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 1994
Query: 2914 QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---L 2970
QWL E+ L+ P E K K +L EL+ + Q V L +
Sbjct: 1995 QWLTEAEQFLRKTQI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEI 2046
Query: 2971 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 3030
+ + +A ++ LN RW+ + R+++LEE + L+ FQ ++ WL E
Sbjct: 2047 IQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE 2106
Query: 3031 KELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
+ + + PL L + +QV+ +++E R+ +QLNE +L
Sbjct: 2107 ADNIASI--PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE 2164
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV- 3148
+++ +L+ N +W++++ L + +I+ I Q ++ L+DL E++ + LS
Sbjct: 2165 QDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2224
Query: 3149 --QSAISTQPE------------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLI 3194
Q I QP AV+ + + EI S + L E Q + +L L
Sbjct: 2225 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2284
Query: 3195 GEQYLKDELKKRL-------------------ETVALPLQGL--EDLAADRI---NRLQA 3230
E + L + L +TV L Q + ++ A ++ + L
Sbjct: 2285 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLML 2344
Query: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
+ + F + + EL WL + LE + + + + + L Q
Sbjct: 2345 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 2404
Query: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
E ++ ++L E + + +++ ++N W+E+ + +R+ +L + ++ + ++
Sbjct: 2405 EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 2464
Query: 3351 HVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407
E+ + +AK+ + T+D +Q + +K + ++ + ++ +++ N A
Sbjct: 2465 AKEEAEQVLGQARAKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLAL 2522
Query: 3408 ILINSSEADED-GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIE 3463
L+ AD+ + IN + ++ + + + +LEE + L++F E F
Sbjct: 2523 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 2582
Query: 3464 KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVED 3519
+ E + L+ +K +++L Q + LQ +E D N +Q ++
Sbjct: 2583 TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS 2642
Query: 3520 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3579
DA L + + ++ E++++ + +E + + H ++E+ L D
Sbjct: 2643 LEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2702
Query: 3580 DELDGMGAIGRDTDSLQSQ---------------------IEDVRLFLNKIHVLKLDIEA 3618
DEL IG D ++Q Q +E VR+FL + + L E
Sbjct: 2703 DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EK 2760
Query: 3619 SEAECRHMLEEEGTLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKL 3677
E R + EE ++ L+++ E +N + KL Q +++ TL R+++
Sbjct: 2761 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2820
Query: 3678 KGLNDATTAAEEAEALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
L+ AE + VG ++ + L K + E + PL+ + VN L + L
Sbjct: 2821 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL 2879
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777
+ G L +E++N RW L V R+ QL EA
Sbjct: 2880 -TTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHEA 2918
Score = 194 bits (492), Expect = 3e-48
Identities = 469/2759 (16%), Positives = 1097/2759 (39%), Gaps = 318/2759 (11%)
Query: 1807 DEKLVSYLSLLRNIEMRTKQIQ--PLELNLAELQDLLCQAKVLERELKDLTTLVSQELEC 1864
++KL L E RT++++ PL +L +L+ + Q KVL+ +L+ V+
Sbjct: 331 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 390
Query: 1865 VNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQH 1924
V + S A ALE+ K L +++ R + Q+ +L +
Sbjct: 391 VVVVDESSGDHATA----ALEEQLKVLGDRWANICRWTEDRWVLLQD--------ILLKW 438
Query: 1925 TQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA 1984
+L AW+ K +N + D + + LQ+ LK + ++K + L
Sbjct: 439 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 498
Query: 1985 FDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV 2044
Q +S Q+ L + LE++ AQ+ +A+
Sbjct: 499 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS-----------QAVT 547
Query: 2045 KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 2104
T Q + + + + V E+ L H Q++L + + +I+ R
Sbjct: 548 TT---QPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDSEIRKR 600
Query: 2105 A----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQEETRV 2154
T + + E ++ + + +E + L+EK++ + E++ LQ+ +R
Sbjct: 601 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660
Query: 2155 AQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLLTNLPG 2210
AQ +E+ V + ++ K +A+++L E + + L+W+ + L
Sbjct: 661 AQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQ 718
Query: 2211 MEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270
+EQ++ + + T P + Q ++ K L Q I +
Sbjct: 719 LEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERLKIQSI 772
Query: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKE 2328
L + G L + + +A K++QT+ D L ++ +
Sbjct: 773 ALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSA 827
Query: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
+W+++SE +L + E + L + + + L +++ + +++
Sbjct: 828 IRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM---- 883
Query: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
K PSEI + + ++ R+ L S+ L + + + QN +L+
Sbjct: 884 ----SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 939
Query: 2449 WMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
WM A V+ L + D +L++QL KQ + +++ Q L V +I
Sbjct: 940 WM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNEGGQKI 992
Query: 2507 EGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2565
+ E P+ ET + + + + + R L+ + ++ S+Q+ L + + + +
Sbjct: 993 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1052
Query: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1053 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1112
Query: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRMLASGNQ 2684
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++ + N
Sbjct: 1113 LKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENI 1172
Query: 2685 PD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1173 PGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LETFNSR 1227
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
+ EL + R+K L+ + +ETE S+ + S++ ++KQ+
Sbjct: 1228 WRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--IDKQLA 1271
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+ D A ++I TS E + +E +QGK +
Sbjct: 1272 AYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA--------------QR 1316
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
+ Q + DV++K+ L ++ + + L + + E L LE+K
Sbjct: 1317 VLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALETKS-- 1369
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2982
+ E V++Q L + +++ V + ++ ++ EN
Sbjct: 1370 ----------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKKQTENP 1415
Query: 2983 KKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
K++ E + + E+ R++QLE+ + + L WL ++ +
Sbjct: 1416 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1475
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
+ P+ L+++ + KE E ++ + + E + + T G + V+ +L
Sbjct: 1476 AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVEDKLSL 1532
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N W+ +T S+ ++ + +YQ+ ++ + V + + + + + E
Sbjct: 1533 LNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKK 1585
Query: 3160 KQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217
K Q +E ++++L + +V + L G D +K +E L
Sbjct: 1586 KPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQISELNHR 1640
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ RI +A++ ++ +Q +++ L+ P+ A+++ Q + E
Sbjct: 1641 FAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGVNLKEE 1687
Query: 3278 EFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 3336
+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L + R+
Sbjct: 1688 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1747
Query: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVE 3393
+ + + +Y+ +DL+ ++D + K++ L D +++ L + K LN V
Sbjct: 1748 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1807
Query: 3394 KRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL--EEMT 3449
++ L +A + + + I + A + A ++ +T + E+M
Sbjct: 1808 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1867
Query: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP----- 3504
+ ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1868 LEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQS 1925
Query: 3505 --QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEG 3560
++D + + ++ A + ++ Q ++Q +F +V + + +E
Sbjct: 1926 SGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEK 1982
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEA 3618
+FH ++ +F+Q ++ I + + + + +++++ + + + + A
Sbjct: 1983 WRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2041
Query: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGRVEDFY 3674
+ E ++++ D L+ +L +LN + C +L++R K +EQ + + +F
Sbjct: 2042 TGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQ 2094
Query: 3675 RKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVN 3730
R L N+ EEA+ + + G E ++ ++L K+ +E PL+ L+Q+N
Sbjct: 2095 RDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLN 2148
Query: 3731 GLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+ + LE
Sbjct: 2149 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2208
Query: 3790 PL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
L L WL+ + P+ E +QE ++ + ++ V+ + ++
Sbjct: 2209 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVEEILSK 2262
Query: 3843 GGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------------ 3887
G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2263 GQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2320
Query: 3888 -----VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEPVGTQT 3921
V+ K+ F+ ++D+LS+ ++ + + +
Sbjct: 2321 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2380
Query: 3922 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSE 3980
I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q ++ E
Sbjct: 2381 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2440
Query: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADH 4040
+Q+ + L++ L ++ + E + E L + KL S + D + ++ +
Sbjct: 2441 VQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITET 2500
Query: 4041 LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 4100
L +++ + NVD A LL+ + ++ + + I + I S+
Sbjct: 2501 KQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAA 2560
Query: 4101 LEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQKELKK 4154
LE+ +L +F E+ WL E E ++ + + + ++ ++L+
Sbjct: 2561 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2620
Query: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTIGQRVD 4208
E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2621 EIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2675
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF------- 4261
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2676 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2735
Query: 4262 ------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAI 4308
+++ +R + +++L+ E+ + T +L+++ E + ++E +
Sbjct: 2736 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2795
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEM 4367
+L +++ +++ + + E +EL + + + P + + L+ E++
Sbjct: 2796 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2855
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
+ LR IA K ++ + + QL +L+P +E+ + + + +++ VRQ
Sbjct: 2856 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 2914
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3831
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 209 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 268
Query: 3832 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3889
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 269 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 326
Query: 3890 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 327 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
+ + + L E++ L R++ I + LL L + E++
Sbjct: 387 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 446
Query: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 4066
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 447 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 506
Query: 4067 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 4113
+ V E D + + T S+A+ T + + T ++
Sbjct: 507 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 566
Query: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 4172
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 567 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 620
Query: 4173 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 4215
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 621 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 680
Query: 4216 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 4259
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 681 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 740
Query: 4260 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 4312
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 741 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 798
Query: 4313 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 4426
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 859 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 908
Query: 4427 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 4472
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 909 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 962
Query: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 963 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1018
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1019 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1078
Query: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1079 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1138
Query: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4708
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1139 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1198
Query: 4709 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4768
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1199 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1248
Query: 4769 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1249 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1305
Query: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1306 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1351
Query: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4948
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1352 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1410
Query: 4949 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 5008
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1411 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1470
Query: 5009 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 5068
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1471 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1529
Query: 5069 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 5099
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1530 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1589
Query: 5100 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 5129
+ K+L L D +DS + ++N D
Sbjct: 1590 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1649
Query: 5130 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1650 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1709
Query: 5188 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 5233
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1710 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1768
Query: 5234 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 5287
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1769 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1826
Query: 5288 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 5347
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1827 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 1883
Query: 5348 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 1884 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 1943
Query: 5396 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 5444
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 1944 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2003
Query: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5504
L + IP+N + K ++ +++E+ V +T
Sbjct: 2004 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2040
Query: 5505 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5564
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2041 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2093
Query: 5565 KEFANFDFDVW 5575
+ N +F +W
Sbjct: 2094 QRDLN-EFVLW 2103
Score = 91.3 bits (225), Expect = 3e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 5087 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 5146
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 208 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 267
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 268 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327
Query: 5206 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 5263
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 328 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 385
Query: 5264 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 5322
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 386 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 445
Query: 5323 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 5380
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 446 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 504
Query: 5381 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 5437
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 505 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 564
Query: 5438 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 5494
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 565 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 618
Query: 5495 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5554
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 619 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 674
Query: 5555 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5614
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 675 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 730
Query: 5615 LASKFPTTKLEMTAV 5629
PTT E TA+
Sbjct: 731 --KIQPTTPSEPTAI 743
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 351 bits (900), Expect = 1e-95
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 384 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 443
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2832
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 444 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
Query: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2892
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 496 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 551
Query: 2893 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2950
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 552 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2991
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 612 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
Query: 2992 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 3024
T+ TV ++RQ+ + ++L
Sbjct: 672 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
Query: 3025 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 3083
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 732 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
Query: 3084 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 792 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 850
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 3202
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 851 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 889
Query: 3203 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 3241
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 890 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 947
Query: 3242 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 3300
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 948 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 1005
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 1006 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1065
Query: 3361 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 3418
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 1066 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1125
Query: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 3477
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 1126 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1185
Query: 3478 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 1186 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1244
Query: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 1245 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1297
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3654
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 1298 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1356
Query: 3655 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3714
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 1357 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1396
Query: 3715 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3772
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 1397 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1443
Query: 3773 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1503
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 1504 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1563
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 1564 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1623
Query: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 1624 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1682
Query: 4001 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 4058
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 1683 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1735
Query: 4059 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 4116
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 1736 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1795
Query: 4117 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 4167
L +++ ++EE + + QR L++ + + R + +
Sbjct: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1855
Query: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 4222
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 1856 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1913
Query: 4223 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 1914 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1965
Query: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
F Q ++E+T ++ + + + + + + +S
Sbjct: 1966 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2010
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 4398
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 2011 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2070
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 4458
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2127
Query: 4459 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4516
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 2128 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2180
Query: 4517 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4576
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 2181 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2239
Query: 4577 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4634
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 2240 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2298
Query: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4694
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 2299 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2355
Query: 4695 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4739
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 2356 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2415
Query: 4740 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4772
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 2416 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2475
Query: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 2476 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2535
Query: 4833 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 2536 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2595
Query: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 2596 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2654
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 2655 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2714
Query: 5012 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 5064
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 2715 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2774
Query: 5065 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 2775 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2834
Query: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 5170
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 2835 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2894
Query: 5171 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 5225
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 2895 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2954
Query: 5226 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 5283
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 2955 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3013
Query: 5284 KGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
L++L+TRW L V+ + R+ Q
Sbjct: 3014 LSTLEDLNTRWKL---LQVAVEDRVRQ 3037
Score = 325 bits (833), Expect = 8e-88
Identities = 518/2775 (18%), Positives = 1115/2775 (40%), Gaps = 293/2775 (10%)
Query: 2772 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2828
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 328 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 382
Query: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2888
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 383 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 438
Query: 2889 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2948
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 439 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 496
Query: 2949 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2998
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 497 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 556
Query: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 3057
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 557 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 605
Query: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 3117
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 606 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 664
Query: 3118 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRS- 3171
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 665 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 723
Query: 3172 ---DLEQLDHEVKEAQTLCD--ELSVLIGEQYLKD-------------ELKKRLETVALP 3213
D+ +L + ++ + E ++ E D E ++L+ +
Sbjct: 724 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 783
Query: 3214 LQGL------EDLAADRINRLQAALASTQ-QFQQMFDELRTWLDDK--------QSQQAK 3258
Q L E + AD I + L S +F Q+ E WL+ + Q QQ +
Sbjct: 784 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 843
Query: 3259 NCPISA----KLE--------RLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306
+A K++ ++SQL+ ++ +N+ SG I +
Sbjct: 844 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---EVNRLSGLQPQIERLKIQSIALKEK 900
Query: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA--QKYQWHVEDLVPWIEDCKA 3364
G+ L V NH++++ R+ L+ +YQ + + W++ +
Sbjct: 901 GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 960
Query: 3365 KMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-EDGIR 3421
K+S +L VT D +E L +A+ + +++++S L L++ + + ++ +
Sbjct: 961 KLSIPQLSVT-DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019
Query: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALG 3480
E I ++ +L LEE +LR+ Q + ++K + L E + ALG
Sbjct: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079
Query: 3481 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3540
K L++ R +Q ++P ++ + Q + +A + AS+L + + ++
Sbjct: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQW 1138
Query: 3541 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3600
+ Q+V + ++ LE + EM + ++E + D LQ +E
Sbjct: 1139 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1198
Query: 3601 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3660
+++ + + ++ ++ + + LK+ELE L L R +
Sbjct: 1199 EMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKC 1258
Query: 3661 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
+ LE + L+ N E + E I++ L + + D
Sbjct: 1259 KTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSED 1318
Query: 3721 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH 3780
Q+ L Q L D + + ++E N+RW L+++ +R L++++
Sbjct: 1319 ----NPNQIRILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI-- 1369
Query: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI-QEQKLLQRLLDDRKATVDML 3839
+ E L + ++ I Q KV AQ+ QE + +Q L + +++ +
Sbjct: 1370 --QSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1427
Query: 3840 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETA-- 3897
+ Q E A R +LS+ QK+L+D+ + + F + A
Sbjct: 1428 KKHN----QGKEAAQR----------------VLSQIDVAQKKLQDVSMKFRLFQKPANF 1467
Query: 3898 ----EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
+ L + L E + +Q Q+ L + + ++V +K G+
Sbjct: 1468 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527
Query: 3954 SLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWL 4013
+ L E++ +L+ Y+E+ + + L++ L +R ++ + WL
Sbjct: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
Query: 4014 AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
A + +L+ + L + A A +EI +K ++ + G+AL K G++
Sbjct: 1588 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKE 1646
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
L+++KL + + + +T + + L L + ++ F + +T W+ + + L S
Sbjct: 1647 TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1706
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
+ P Q + K LK E+ + R +D+ + + L+ R+ ++ +S+ N
Sbjct: 1707 KKKPQ-----QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 1761
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTA 4253
++ +S I + + ++ +Q+ ++++ + E + G E+D
Sbjct: 1762 HRFAAISHRI--KTGKASIPLKELEQF----NSDIQKLLEPLEAEIQQGVNLKEEDFNKD 1815
Query: 4254 QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNS 4313
+ + ++++ D++ + + E ++ ++ K + L ++ A+ L S
Sbjct: 1816 MNEDNEGTVKELLQRGDNLQQRITD---------ERKREEIKIKQQLLQTKHNALKDLRS 1866
Query: 4314 ERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRES 4373
+R + Q+ ++L +++ +A LP P D ++++ E+++ +E
Sbjct: 1867 QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKKEE 1925
Query: 4374 IAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQ-----------IKEE--- 4419
+ + + L + G + + P + ++ +++++ E+ +AQ ++EE
Sbjct: 1926 LNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKRWREIESKFAQFRRLNFAQIHTVREETMM 1983
Query: 4420 VRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNK 4479
V + L+ + ST +TE + +LE + L++ P L + + + + K
Sbjct: 1984 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA----PDLCAKDFEDLFKQEESLK 2039
Query: 4480 SATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEER 4539
+ L++ + + + + + ++ ++Q+ L Q+ F WE + ++R
Sbjct: 2040 NIKDSLQQSSGRIDIIHSKKTAALQSATPVER----VKLQEALSQLDFQWEKVNKMYKDR 2095
Query: 4540 EIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET---IKE 4596
+ +F +E +F YD+ + + + + + P + E A+ +KE
Sbjct: 2096 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKE 2147
Query: 4597 ETDGLHEELEFIRIL---GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4653
DG+ + +R L G ++I +T+ +++ + +N W+ + K +R ++LE
Sbjct: 2148 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2207
Query: 4654 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4713
+ ++Q L WL+ + ++P +K++L ++K E+ +Q
Sbjct: 2208 EQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2266
Query: 4714 MEKLNHQGELMLKKAT-DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
+++LN G +L A ++D + L + W + + +Q ++E + LGQ
Sbjct: 2267 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2326
Query: 4773 QHALEEL-------MSWLTHTEELLDA--QRPISGDPKVIEVELAKHHVLKNDVLAHQAT 4823
+ LE+L + WL+ L+ Q G V E E+A V A Q
Sbjct: 2327 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPD 2378
Query: 4824 VETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV---LQKTEEREQQLQSTLQQAQG 4880
VE + G L + ++ +LE ++ W++V LQ+ ++ L L
Sbjct: 2379 VEEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGA 2436
Query: 4881 FHSEI----------EDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
++ ++ + M S L P A +L + L Q+ +
Sbjct: 2437 SPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2496
Query: 4931 -------ETYNQLLDKGRLML-------------------LSRDDSGSGSKT--EQSVAL 4962
E N+++ K + + L S ++T +
Sbjct: 2497 RVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIER 2556
Query: 4963 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 5022
++ +W V ++ R+ +L E L +T++ + +E L A L ++ +
Sbjct: 2557 IQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 2616
Query: 5023 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 5082
+I E K A ++ + + + +L D + + ++ + W + +R
Sbjct: 2617 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 2676
Query: 5083 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD------SELEISNDPDKIKLQLS 5136
ER +L++ + +QF +K + WL +AE+ + + + D +K +
Sbjct: 2677 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2736
Query: 5137 KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 5196
+ ++ Q + VY + + +D+ L L + KW + KS+
Sbjct: 2737 QWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2796
Query: 5197 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 5256
+ LE + + +LQ L+ WL + +L+ P+ GD V D H+ F++EL
Sbjct: 2797 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2856
Query: 5257 KRTGTV-------------------QVLKRSGRELI--ENSRDDTTWVKGQLQELSTRWD 5295
+ + + L + REL E +++ T ++ Q +E++T W+
Sbjct: 2857 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2916
Query: 5296 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 5355
+ S Q ++++ L++ + ++ L L +AE + D LID+
Sbjct: 2917 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDS 2970
Query: 5356 HKEFMKKVEEKRVDV 5370
++ ++KV+ R ++
Sbjct: 2971 LQDHLEKVKALRGEI 2985
Score = 322 bits (826), Expect = 5e-87
Identities = 541/2849 (18%), Positives = 1142/2849 (40%), Gaps = 300/2849 (10%)
Query: 2834 EITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK-LGGVLHE 2890
+IT +QG +T S P S + Y T D T + +K G L E
Sbjct: 277 QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLME 336
Query: 2891 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2950
+ +L +EEV L WL S E+ L++ +S+ E VK Q +++ ++
Sbjct: 337 SEVNLDRYQTALEEV-------LSWLLSAEDTLQAQGEISNDV--EVVKDQFHTHEGYMM 387
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 3007
+L + ++ + + + L+ T S++ E ++QE+ LNSRWE ++ +Q L
Sbjct: 388 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWECLRVASMEKQSNL 445
Query: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLG--PLSIDPNMLNAQKQQVQFMLKEFEAR 3065
L + E L WL + E + PL D L Q QQ + + ++ E
Sbjct: 446 HRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQE 503
Query: 3066 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 3125
+ + L + GD + T+ ++++L+ + +W + R
Sbjct: 504 QVRVNSLTHMVVVVDESSGDHA--TAALEEQLKVLGDRWANICRWTEDR----------- 550
Query: 3126 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 3185
LLQD+ K + + + + SA ++ E ++ T K+
Sbjct: 551 ---WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTG------------FKDQNE 595
Query: 3186 LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 3245
+ L L LK +L+K+ +++ +DL + N+ + TQ+ + D
Sbjct: 596 MLSSLQKLA---VLKADLEKKKQSMGKLYSLKQDLLSTLKNK-----SVTQKTEAWLDNF 647
Query: 3246 -RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 3304
R W + Q + IS + Q L + + ++ + +++V + L
Sbjct: 648 ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVME-TVTTVTTREQILVKHAQEEL-PP 705
Query: 3305 PPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKA 3364
PP ++KR + T D + R ++ + +L WI +A
Sbjct: 706 PPPQKKRQI-----------------TVDSEIR--------KRLDVDITELHSWITRSEA 740
Query: 3365 KMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL--LEILNSAADILIN---SSEADEDG 3419
+ + + S L+ K E EK L+ + +A L+ + + D
Sbjct: 741 VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADS 800
Query: 3420 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDAL 3479
I+ +N + L + LE + F + +E+ A++ L+I
Sbjct: 801 IKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQLEQMTTTAENWLKIQPTT 859
Query: 3480 GSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQGLVE--DAPDGSDASQLLHQAEV 3535
S+ + K+ K+ + EV L L+PQ++ L+ + L E P DA +
Sbjct: 860 PSEPTAIKSQLKI-CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHF 918
Query: 3536 AQQEFLEVKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAIGR--- 3590
+Q F +V+ R E +L+ I R +E S + + + +I +
Sbjct: 919 -KQVFSDVQAR--------EKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 969
Query: 3591 -DTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3649
D + ++ ++ +++ + + + + + M ++ + + E E + +
Sbjct: 970 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 1029
Query: 3650 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3709
KL+ + ++LE + ++ ++ L + +W + EI+ +QL
Sbjct: 1030 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 1089
Query: 3710 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3769
++ + + +Q L VN GQ + A + LE +++E+N +W+ + ++V
Sbjct: 1090 QCRLLVSD-IQTIQPSLNSVNEGGQKIKNEAEPEF-ASRLETELKELNTQWDHMCQQVYA 1147
Query: 3770 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV---VKAQIQEQKLLQ 3826
R L+ L Q L + W+ EE + EYK ++ ++E K +
Sbjct: 1148 RKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLER---DFEYKTPDELQKAVEEMKRAK 1204
Query: 3827 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3886
++A V +L + A +E + +LE+L + + L ++ + K LE++
Sbjct: 1205 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1264
Query: 3887 LVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946
+ E + +L+ E KL +E + +I + + +LE + + + +
Sbjct: 1265 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL---DSLENLMRHSEDNPN 1321
Query: 3947 QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDE 4006
Q + Q+L+ +++E++++ +R+ E+ + R+ LL+Q++ +A+ E
Sbjct: 1322 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQET-EKS 1378
Query: 4007 VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL-L 4065
+ ++ DK + ++ D Q A + ++ + + ++++ K+ Q
Sbjct: 1379 LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSDLTSHEISLEEMKKHNQGKEA 1436
Query: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
Q ++ + Q+KL + ++ + Q F+ +E L EV
Sbjct: 1437 AQRVLSQIDVAQKKLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEV 1481
Query: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
+ L +S E + L K + E + ++ V + R +++ + L
Sbjct: 1482 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1541
Query: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
D+ V+ Y + + +R +++ ++ S++ + + W+A T +L +
Sbjct: 1542 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1601
Query: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
+++ KA +I + K + + +E+ GE KTVL +K E+L++
Sbjct: 1602 GMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV----GEALKTVLGKK-ETLVE-- 1650
Query: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEETRALIAQLPSPAIDHEQLRQ 4362
+ +SLLNS A RA+ +N E + + + ++ I Q + + E+ +
Sbjct: 1651 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710
Query: 4363 QQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE----MVEEKYQKAENMYAQI 4416
QQ+E +++L+ + + +P +D Q L G+ +VE + + + +A I
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGDHCRKLVEPQISELNHRFAAI 1767
Query: 4417 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLSSRLRMPPLIPAEVDKIRECI 4475
++ +A ++ +F+ I+ +LE LE + + + E D ++
Sbjct: 1768 SHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK-----EEDFNKDMN 1817
Query: 4476 SDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKAR 4535
DN+ EL +RG+ L Q + +EI+ K + +K
Sbjct: 1818 EDNEGTVKEL----------LQRGDNL---QQRITDERKREEIKIKQQLLQTKHNALKDL 1864
Query: 4536 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIK 4595
+R K L++ ++ LL + D + + L P D IK+ + K
Sbjct: 1865 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-DERKIKEIDRELQKKK 1923
Query: 4596 EETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN-----KTWKERLE 4650
EE + + + E + GA + + + + + I+ + LN +E +
Sbjct: 1924 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1983
Query: 4651 KLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLCTMPPV-GTDLNTVKDQLNEM 4700
+ + M + Y + QA+ + V +L P + D + Q +
Sbjct: 1984 VMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLLNAPDLCAKDFEDLFKQEESL 2038
Query: 4701 KEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4760
K K + Q ++ ++ + L+ AT +R ++E L++L WE + + RQ
Sbjct: 2039 KNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEALSQLDFQWEKVNKMYKDRQG 2097
Query: 4761 KLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
+ + ++ +F + ++ WLT E+ L Q P + + + L + L++ +
Sbjct: 2098 RFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQDGIGQ 2154
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Q V T+N G E+++ S+ DAS L+ +L ++N W+ V ++ +R+++L+
Sbjct: 2155 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2214
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
F ++ +F+L L ++ +++ G + +E+L+ L +L ++ QL +
Sbjct: 2215 EFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNET 2273
Query: 4940 GRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4998
G +L+S S K E + +W VS + E++ ++E + + + L++
Sbjct: 2274 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2333
Query: 4999 -------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 5051
+ WL+ L I + P+ ++E ++ V A + + E+ G
Sbjct: 2334 EEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AVQAKQPDVEEILSKGQ 2387
Query: 5052 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------------------------------ 5081
L +K +K L + S W+ V +
Sbjct: 2388 HL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445
Query: 5082 -----------RSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK 5130
+E SL F+ AW +L DWL + + S+ + D +
Sbjct: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505
Query: 5131 IKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVC 5190
I + K K + L ++P + I + LK KT E + + + ++++WD V
Sbjct: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565
Query: 5191 GKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
R+ +L E L S Q+++A + L + +L + +D + + K
Sbjct: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625
Query: 5251 FQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLE 5309
K+L + V V +L+ + S DDT V + ++ W ++ K +++ LE
Sbjct: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
Query: 5310 QALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTH--KEFMKKVEEKR 5367
+ + + F + L WL+EAE T L D T + L D+ KE MK+ ++ +
Sbjct: 2686 ETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2742
Query: 5368 VDVNSAVAM--------GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
++ + + +++ ++ D ++ + + ++ E+ + + LE
Sbjct: 2743 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2802
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
+ + L+ELL W+Q + L + Q PI + V+ H+ F E+ K+P
Sbjct: 2803 SSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEP 2860
Query: 5480 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TPPPMPILSQSEAKNPRINQLS 5537
+ +E E+ G K +P PP + + + +++
Sbjct: 2861 VI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVN 2912
Query: 5538 ARWQQVWLLALERQRKLNDALDRLEELKE 5566
W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 2913 TEWEKLNLHSADWQRKIDETLERLQELQE 2941
Score = 296 bits (757), Expect = 5e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 343 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
Query: 2498 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2557
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 401 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 458
Query: 2558 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 459 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 518
Query: 2616 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2671
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 519 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 578
Query: 2672 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2731
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 579 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 638
Query: 2732 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2778
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 639 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 696
Query: 2779 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2828
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 697 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756
Query: 2829 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2879
+L ++ A + Q + S V V + K +E +N
Sbjct: 757 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 810
Query: 2880 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 811 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 861
Query: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2990
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 862 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 915
Query: 2991 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 3048
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
Query: 3049 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 3107
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 976 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1032
Query: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 3167
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092
Query: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 3223
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 1093 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1143
Query: 3224 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 3279
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 1144 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1203
Query: 3280 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 3339
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 1204 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1262
Query: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 3398
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 1263 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1322
Query: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 1323 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1378
Query: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 1379 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1434
Query: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3578
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 1435 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1481
Query: 3579 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 1482 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1541
Query: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3698
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 1542 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1601
Query: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3758
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 1602 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1658
Query: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3816
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1718
Query: 3817 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3872
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 1719 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1771
Query: 3873 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3930
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 1772 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1808
Query: 3931 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3988
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 1809 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1868
Query: 3989 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 4041
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 1869 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1923
Query: 4042 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 4096
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 1924 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980
Query: 4097 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 4151
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 1981 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2040
Query: 4152 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 2041 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2100
Query: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 4270
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 2101 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2157
Query: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 2158 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2217
Query: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 2218 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2276
Query: 4391 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 2277 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2333
Query: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 2334 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2387
Query: 4508 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 2388 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2435
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
SP +++ Q V ET K E
Sbjct: 2436 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2460
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
+ S+ A + N+ W E + DWL + + +
Sbjct: 2461 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2499
Query: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 2620 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2679
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4920
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 2680 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2739
Query: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 2740 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2799
Query: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 2800 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2859
Query: 5041 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 5080
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 2860 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2919
Query: 5081 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 2920 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2976
Query: 5141 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 5198
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 2977 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3036
Query: 5199 KLEEA 5203
+L EA
Sbjct: 3037 QLHEA 3041
Score = 244 bits (622), Expect = 2e-63
Identities = 502/2853 (17%), Positives = 1100/2853 (38%), Gaps = 303/2853 (10%)
Query: 2296 EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355
+ + +SL +SE L + QT +E+ SWL +E L+ + + E +
Sbjct: 328 KSFGSSLMESEVNLDRYQTALEEVL----------SWLLSAEDTLQAQGEISNDVEVVKD 377
Query: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415
+ D+ +H+G + + G K++ GK + V++++ R+
Sbjct: 378 QFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQEQMNLLNSRW 431
Query: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475
L S+L+ +L L W+ E K+ + + D L+ Q
Sbjct: 432 ECLRVASMEKQSNLHRVLMDLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 489
Query: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ----------------- 2518
+ K LQE+L + QV V L + + E G+ A Q
Sbjct: 490 VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 549
Query: 2519 --ETTDSILSHFQSL-------SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569
IL +Q L S L+E+ + K Q + S LQ + ++ +
Sbjct: 550 RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 609
Query: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2629
LE K+ S +++ L + +K K + ++ L+ ++ + +TA + Q
Sbjct: 610 LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 669
Query: 2630 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ----P 2685
+ ++ ++ +++L +H +L K R + ++
Sbjct: 670 TTTQPSLTQTTVMETVTTVTTREQIL-----VKHAQEELPPPPPQKKRQITVDSEIRKRL 724
Query: 2686 DQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL--DLCQHQDRVQNLRKDF 2743
D DIT I ++ + + E ++L A+ + + ++Q+ +
Sbjct: 725 DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 784
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEH 2803
L + + +A S ++ ++ F + L E + ++ +Q+E
Sbjct: 785 QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 844
Query: 2804 LKSLLDDWAS-KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS-SVGSVNGY 2861
+ + ++W + T E + L+ D + + P + + S+
Sbjct: 845 MTTTAENWLKIQPTTPSEPTAIKSQLK------ICKDEVNRLSGLQPQIERLKIQSIALK 898
Query: 2862 HTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV-HKEANSVLQ-WLESK 2919
+ + D ++++ + R++ LQ I + + + ++E S ++ W++
Sbjct: 899 EKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS 958
Query: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEA 2979
E L S T E ++ + +A + L++ + + + + P S+ +
Sbjct: 959 ETKLSI--PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1015
Query: 2980 ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
++ EE+ RW++ + V ++LEE + L Q L+ W+ E ++ +
Sbjct: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
P D +L Q +Q + ++ + + + +NE Q I S+++ EL+
Sbjct: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKE 1133
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N +W + ++ +R + + K+ Q+ L ++ E + + + P+ +
Sbjct: 1134 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1193
Query: 3160 KQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE--QYLKDELKKRLETVALPLQGL 3217
++ +EE + + +Q + +VK L + ++ +I + ++ LKK LET+ Q L
Sbjct: 1194 QKAVEEMKRAKEEAQQKEAKVK---LLTESVNSVIAQAPPVAQEALKKELETLTTNYQWL 1250
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ L+ A + ++ WL++ + + I E + L E
Sbjct: 1251 CTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLE 1310
Query: 3278 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 3337
+ + ++ G + +L + W EL ++ RQ
Sbjct: 1311 NLMRHSEDNPNQIRILAQ------TLTDGGVMDELINEELETFNSRWRELHEEAVRRQKL 1364
Query: 3338 LKDCMQKAQKYQWHV-----------EDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSK 3386
L+ +Q AQ+ + + + L +I D K+ ++ + +++S L +
Sbjct: 1365 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIAD---KVDAAQMPQEAQKIQSDLTSHE 1421
Query: 3387 AMLNEVEKRRSLLEILNSAADILINSSEADEDGIRD--EKAGINQNMDAVTEELQAKTGS 3444
L E++K E AA +++ + + ++D K + Q + LQ
Sbjct: 1422 ISLEEMKKHNQGKE----AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1477
Query: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504
L+E+ L + K++E++V Q+ N + ++ EV +E
Sbjct: 1478 LDEVKMHLPALET--KSVEQEV--------------VQSQLNHCVNLYKSLSEVKSEVEM 1521
Query: 3505 QVDYLRNFTQGLVEDAPDGSD---ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
+ R Q + P D + LH E+ + E KQ++ C+ + K+
Sbjct: 1522 VIKTGRQIVQKKQTENPKELDERVTALKLHYNELG-AKVTERKQQLEK-CLKLSRKMRK- 1578
Query: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI-----EDVRLFLNKIHVLKLDI 3616
+ + LA D EL A+ +L S++ + K+H LK
Sbjct: 1579 -----EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH-LKSIT 1632
Query: 3617 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL---GRVEDF 3673
E EA + +L ++ TL ++ +L LN +T R +E L L L +E F
Sbjct: 1633 EVGEA-LKTVLGKKETL----VEDKLSLLNSNWIAVTSRA---EEWLNLLLEYQKHMETF 1684
Query: 3674 YRKL----KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3729
+ + K + A T +E+E + QQ D K +++ ++ K+
Sbjct: 1685 DQNVDHITKWIIQADTLLDESEKKK----------PQQKEDVLKRLKAELNDIRPKVDST 1734
Query: 3730 NGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
L+ + G C + +E + E+N R+ ++ ++ GK L+
Sbjct: 1735 RDQAANLMANRGDHCR-KLVEPQISELNHRFAAISHRI------------KTGKASIPLK 1781
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
L + +D ++L+ +P AE + ++E+ + + +D + TV L G + Q
Sbjct: 1782 ELEQFNSDIQKLL---EPLEAEIQ-QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837
Query: 3850 -AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908
+ RE+I + + L+++ L + R+K+ +I Q+ A+ + L E
Sbjct: 1838 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1897
Query: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
KKLA S P KI++ + L++ E QA + + +++ Q LS
Sbjct: 1898 KKLA-SLPEPRDERKIKE---IDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS 1953
Query: 3969 EKIDSLQARYSEI------QDRCCRKAALL----DQALSNARL---FGEDEVEVLNWLAE 4015
++ +++++++ Q R+ ++ D L + + + + V L E
Sbjct: 1954 KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE 2013
Query: 4016 VEDKLSS--VFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEV 4073
VE L++ + KDF+ L +Q + + + +D A L+ T E
Sbjct: 2014 VEQLLNAPDLCAKDFED--LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2071
Query: 4074 LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG 4133
+ +QE L + ++ + +++ + +F + WL E E+ L +
Sbjct: 2072 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT- 2130
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN 4193
Q P + +++ KEL+ + + + V+ T+N +++ L + + N
Sbjct: 2131 -QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLN 2189
Query: 4194 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLE---QDQ 4250
+++ V + R ++ ++++ + + W+ E + I LE + Q
Sbjct: 2190 LRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN----IASIPLEPGKEQQ 2245
Query: 4251 TTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAI 4308
+L+ K ++ + + +L + E++ L+ K + Q+ +
Sbjct: 2246 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKV 2305
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE-EM 4367
S E+ +E + Q + E+L + ++ + + + Q Q+ ++
Sbjct: 2306 SRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDV 2365
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK---EEVRQR- 4423
++ ++ +P ++++L G L + P + V+ K + + + + +E+R +
Sbjct: 2366 QETEIAVQAKQPDVEEILSKGQHLYKEKPAT-QPVKRKLEDLSSEWKAVNRLLQELRAKQ 2424
Query: 4424 ------------------ALALDEAVSQSTQITEFHDKIEPMLET--------------- 4450
L V++ T I++ MLE
Sbjct: 2425 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2484
Query: 4451 -LENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4509
L L ++ ++ +++ I E I K+ +LE+ +P E L + L ++
Sbjct: 2485 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2544
Query: 4510 DKDLAAKEIQDKLDQMVFFWEDIKARAEER----------EIKFLDVLELAEKFWYDMAA 4559
+ A I D+++++ W++++ + R ++L+ E AE+ A
Sbjct: 2545 E---ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2601
Query: 4560 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4619
L + K+ V ++ + + + + +T + + L L+ +R AD
Sbjct: 2602 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL--ALKLLRDYSAD----- 2654
Query: 4620 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD----- 4674
+T K V + +N +W +++K ER LE+ + Q+ L+ WL
Sbjct: 2655 -DTRK--VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2711
Query: 4675 -NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4733
N + + D VK+ + + ++ + E+ L+ + +L+ D
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2771
Query: 4734 RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ 4793
+++ L + W L +K + + LE + + +L+EL+ WL ++ L Q
Sbjct: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831
Query: 4794 RPISGDPKVIEVELAKHHVLKNDVLAHQ----ATVETVN-------KAGNELL------- 4835
PI GD ++ + H K ++ + +T+ETV G E L
Sbjct: 2832 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2891
Query: 4836 --ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELT 4893
E A + LR + E +N WE + + + ++++ TL++ Q ++ L+L
Sbjct: 2892 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2951
Query: 4894 RMESQLSASKPTGG-LPETAREQLDTHMELYSQLKAKEETYNQLLDKGR-LMLLSRDDSG 4951
+ E + +P G L ++ ++ L+ L ++ +E + + D R L L S
Sbjct: 2952 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3011
Query: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
T + L +W ++ +E+R +L EA
Sbjct: 3012 YNLSTLED---LNTRWKLLQVAVEDRVRQLHEA 3041
Score = 226 bits (575), Expect = 7e-58
Identities = 493/2775 (17%), Positives = 1066/2775 (38%), Gaps = 371/2775 (13%)
Query: 1952 SEIDVDSLNLCLQQY-------EDLKQPMAERKAQLDALAFDIQFFISE-HAQDLSPQQN 2003
SE+++D L++ ED Q E ++ + QF E + DL+ Q
Sbjct: 337 SEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD--QFHTHEGYMMDLTAHQG 394
Query: 2004 R--QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC------- 2054
R +L+L ++L + + + E +V L + V +++KQ N
Sbjct: 395 RVGNILQLGSKLIGTGK-LSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 453
Query: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSF 2108
+Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 454 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
Query: 2109 ATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVAQK 2157
VV + G +EE L R R L +++ L EE +
Sbjct: 514 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 573
Query: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 574 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLLST 630
Query: 2218 SLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 2276
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 631 LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT---- 686
Query: 2277 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWLER 2335
+T EQ +++ E L + K+ T+ E++K L D E SW+ R
Sbjct: 687 -TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWITR 737
Query: 2336 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 2395
SE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 738 SEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 788
Query: 2396 EPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWMQA 2452
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 789 EQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTT 848
Query: 2453 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2512
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 849 AENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ--- 902
Query: 2513 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQNL 2570
+ + +HF+ + + R LQ QE++ ++ + + E L
Sbjct: 903 GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 962
Query: 2571 EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKL 2630
Q+S ++++ L L+ + Q+S L V + A S + Q +
Sbjct: 963 SIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEF 1022
Query: 2631 AEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2683
E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 1023 EEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD-- 1080
Query: 2684 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDF 2743
+ + +Q + L +++ Q +L+++ ++ + + + ++ L +
Sbjct: 1081 --SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1138
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIE 2802
+ + V R++ E+ +K + +W+ + E + + EL+K +E
Sbjct: 1139 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1198
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+K ++ K V+ + T N ++ P +Q
Sbjct: 1199 EMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ--------------------- 1233
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 1234 -----EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1288
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQEAE 2980
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 1289 LKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE--- 1343
Query: 2981 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 3040
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 1344 -----LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA 1398
Query: 3041 LSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 3097
+D + + Q++Q L E ++H Q EAAQ +L+ QK+L
Sbjct: 1399 DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQKKL 1451
Query: 3098 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE 3157
Q ++ K+ + K +++ LQ+ + V L S + E
Sbjct: 1452 QDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQE 1496
Query: 3158 AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLETV 3210
V+ QL + L ++ EV E+ + G Q ++ EL +R+ +
Sbjct: 1497 VVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVTAL 1548
Query: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
L L +R +L+ L +++ ++ + L WL + K + L
Sbjct: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
S++ + QK + + + I GE+L + G+++ ++++L L ++W ++ +
Sbjct: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVTSR 1666
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
+ + L + + + + +V+ + WI + E P Q E L R KA LN
Sbjct: 1667 AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELN 1725
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS--LEEM 3448
++ R + + AA+++ N + + + + +N A++ ++ S L+E+
Sbjct: 1726 DI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL 1783
Query: 3449 TQRLREFQESFKNIEKKVE--------------------GAKHQLEIFDALGSQACSNKN 3488
Q + Q+ + +E +++ K L+ D L + +
Sbjct: 1784 EQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1843
Query: 3489 LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3548
E+++ +Q++LQ + LR+ + A ++ HQ +++ ++ + ++
Sbjct: 1844 REEIKIKQQLLQTKHNALKDLRSQRR---------KKALEISHQWYQYKRQADDLLKCLD 1894
Query: 3549 SGCVMMENKLEGIGQ--FHCRVREMFSQLADLDDELDGM--GAIGRDTDSLQSQIEDVRL 3604
+E KL + + +++E+ +L +EL+ + A G D +E ++
Sbjct: 1895 D----IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI 1950
Query: 3605 FLNK-------------------IHVLK----------LDIEASE------AECRH---- 3625
L+K IH ++ + +E S E H
Sbjct: 1951 QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQA 2010
Query: 3626 MLEEEGTLDLLGL-KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684
+LE E L+ L ++ E L KQ E K ++ L+ + GR++ + K +
Sbjct: 2011 LLEVEQLLNAPDLCAKDFEDLFKQ----EESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2066
Query: 3685 TAAEEA---EAL-----QWV----------------------VGTEVEIINQQLADFKMF 3714
T E EAL QW +++I NQ L + + F
Sbjct: 2067 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2126
Query: 3715 QKEQVDP---------------------LQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753
++ P Q ++ +N G+ +IQ + K D L+ +
Sbjct: 2127 LRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSK-TDASILQEKL 2185
Query: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3813
+N RW + K+++ R +L+E +FQ L + WL + + + + P E +
Sbjct: 2186 GSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQ 2245
Query: 3814 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA--DREKITGQLESLESRWTE 3871
+K ++++ KLL L R+ + L GG + SA ++ +++K+ +L+ +W +
Sbjct: 2246 -LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2304
Query: 3872 ----LLSKAAARQKQLEDILVLAKQFHETAEPISDFL----SVTEKKLANSEPVGTQTAK 3923
L K + Q++D+ L K+ + E ++ L + + ++P
Sbjct: 2305 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD 2364
Query: 3924 IQQQIIRHKALEEDIENHATDVHQAVK-------IGQSLSSLTSP------------AEQ 3964
+Q+ I +A + D+E + K + + L L+S A+Q
Sbjct: 2365 VQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQ 2424
Query: 3965 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-------------FGEDEVEVLN 4011
L+ + ++ A ++ + + A+S + F E+ +
Sbjct: 2425 PDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD 2484
Query: 4012 WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE 4071
WL+ ++ + S V + ++ A +++ R+ +++ I Q L +T+ +
Sbjct: 2485 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 2544
Query: 4072 EV-LLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 4130
E +I ++++ I+ ++ ++ + L + + +T++ EE L + +L
Sbjct: 2545 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 2604
Query: 4131 TSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 4190
+ T + I + K+L K++ + + +D N+++ LL + +
Sbjct: 2605 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 2664
Query: 4191 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----- 4245
+ N ++ + + +R ++ + QQ+ + LAW+ E + L
Sbjct: 2665 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2724
Query: 4246 LEQDQTTAQLQVQ-KAFSIDIIRHKDSMDELFSHRSEIFGTC-GEEQKTVLQEKTESLIQ 4303
LE + +L Q + +I H D L + +I + G + +LQ + +++
Sbjct: 2725 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2784
Query: 4304 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 4363
++ + + + LE + + + +EL W++ +++ D +++Q
Sbjct: 2785 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2844
Query: 4364 QEEMRQLRESIAEHKPHIDKLLKIG---------PQLKELNPEEGEM-VEEKYQKAENMY 4413
+ R + + +P I L+ L++L E E+ EE+ Q +
Sbjct: 2845 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2904
Query: 4414 AQIKEEVRQRALALD-EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 4472
+ EEV L+ + +I E ++++ + E + L +LR +I +
Sbjct: 2905 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2964
Query: 4473 ECISDNKSATVELEK 4487
+ + D+ +E K
Sbjct: 2965 DLLIDSLQDHLEKVK 2979
Score = 204 bits (518), Expect = 3e-51
Identities = 414/2141 (19%), Positives = 854/2141 (39%), Gaps = 303/2141 (14%)
Query: 1804 LEHDEKLVSYLSLLRNIEMRTKQIQP----LELNLAELQDLLCQAKVLERELKDLTTLVS 1859
+EH +KL ++ LR I+ + ++ +++ L E L +++L+++LK LVS
Sbjct: 1037 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVS 1096
Query: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK 1919
+++ + + S + +A + A L+ L ++ W+ H V K
Sbjct: 1097 -DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD----HMCQQVYARKEA 1151
Query: 1920 V---LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER 1976
+ L + L+ L ++ W+ + + D L +++ + K+ ++
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQK 1210
Query: 1977 KAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQ 2036
+A++ L + I++ P + + L L ++Q + + +
Sbjct: 1211 EAKVKLLTESVNSVIAQ----APPVAQEALKKELETLTTNYQWLCTRLNGK--------- 1257
Query: 2037 QMEQEALVKTLQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQ------QDLSAL 2087
KTL++ H+ LE W+ + E L +TT+ +++S +
Sbjct: 1258 -------CKTLEEVWACWHELLSYLEKANKWLNEVEFKL-----KTTENIPGGAEEISEV 1305
Query: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
+ +L +D N+ A + D G M+E + E+L ++
Sbjct: 1306 LDSLENLMRHSEDNPNQIRILAQTLTD-GGVMDE-----------LINEELETFNSRWRE 1353
Query: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 2207
L EE QK LE+++ SA QETEKS + E+ ID L + Q+
Sbjct: 1354 LHEEAVRRQKLLEQSIQSA--QETEKS--LHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1409
Query: 2208 LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE------LLSQQQNF 2261
++ S + + +L+ + +A +++ Q ++ + + Q+ L + NF
Sbjct: 1410 AQKIQ--SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF 1467
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ---------- 2311
Q ++ LD+ +L E + ++Q++ + + + +L +S +E+K
Sbjct: 1468 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1527
Query: 2312 --VQTLQDELQKFLQD---------------------------------HKEFE---SWL 2333
VQ Q E K L + KE WL
Sbjct: 1528 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1587
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
++ EL P L S + + +++ K L+ +T G+ + +
Sbjct: 1588 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----L 1642
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWM 2450
GK+ + LV+DKL + A+ S R LN+LL Q H F + D + W+
Sbjct: 1643 GKKET----LVEDKLSLLNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI 1695
Query: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2510
+ LL ++ P Q++ K+L+ EL + + V+ + A ++M G
Sbjct: 1696 ----IQADTLLDESEKKKP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-- 1746
Query: 2511 APDH-RHVQETTDSILSH-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSI 2563
DH R + E S L+H F ++S+ + ++S+ K + Q Q + E LE+ +Q
Sbjct: 1747 --DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1804
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTT 2622
+++ K ++ + G ++E L L+Q I ++ E ++ + + A
Sbjct: 1805 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1864
Query: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2682
+ + K E+S ++ Q ++ + L + +++ + LAS
Sbjct: 1865 RSQRRKKALEISHQWYQ---------------------YKRQADDLLKCLDDIEKKLASL 1903
Query: 2683 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
+P + ++I+E++ E++ ++E L+ + LS G A+ + +
Sbjct: 1904 PEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV------------E 1946
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
T++Q + + RE ++ Q + F + + T ++ P E S +I
Sbjct: 1947 PTQIQLSKRWREIESKFAQFRRLNFAQ-IHTVREETMMVMTEDMPLEISYVPSTYLTEIT 2005
Query: 2803 HLKSLL---------DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS 2853
H+ L D +K E++ + SL+N+ DS ++ + + S
Sbjct: 2006 HVSQALLEVEQLLNAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHS 2057
Query: 2854 SVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVL 2913
+ T + ++Q +S ++ ++EK+ + +RQ + + H +
Sbjct: 2058 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 2117
Query: 2914 QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---L 2970
QWL E+ L+ P E K K +L EL+ + Q V L +
Sbjct: 2118 QWLTEAEQFLRKTQI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEI 2169
Query: 2971 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 3030
+ + +A ++ LN RW+ + R+++LEE + L+ FQ ++ WL E
Sbjct: 2170 IQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE 2229
Query: 3031 KELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
+ + + PL L + +QV+ +++E R+ +QLNE +L
Sbjct: 2230 ADNIASI--PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE 2287
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV- 3148
+++ +L+ N +W++++ L + +I+ I Q ++ L+DL E++ + LS
Sbjct: 2288 QDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI 2347
Query: 3149 --QSAISTQPE------------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLI 3194
Q I QP AV+ + + EI S + L E Q + +L L
Sbjct: 2348 RNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLS 2407
Query: 3195 GEQYLKDELKKRL-------------------ETVALPLQGL--EDLAADRI---NRLQA 3230
E + L + L +TV L Q + ++ A ++ + L
Sbjct: 2408 SEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLML 2467
Query: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
+ + F + + EL WL + LE + + + + + L Q
Sbjct: 2468 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQL 2527
Query: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
E ++ ++L E + + +++ ++N W+E+ + +R+ +L + ++ + ++
Sbjct: 2528 EELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLE 2587
Query: 3351 HVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407
E+ + +AK+ + T+D +Q + +K + ++ + ++ +++ N A
Sbjct: 2588 AKEEAEQVLGQARAKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLAL 2645
Query: 3408 ILINSSEADED-GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIE 3463
L+ AD+ + IN + ++ + + + +LEE + L++F E F
Sbjct: 2646 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL 2705
Query: 3464 KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVED 3519
+ E + L+ +K +++L Q + LQ +E D N +Q ++
Sbjct: 2706 TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS 2765
Query: 3520 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3579
DA L + + ++ E++++ + +E + + H ++E+ L D
Sbjct: 2766 LEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2825
Query: 3580 DELDGMGAIGRDTDSLQSQ---------------------IEDVRLFLNKIHVLKLDIEA 3618
DEL IG D ++Q Q +E VR+FL + + L E
Sbjct: 2826 DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EK 2883
Query: 3619 SEAECRHMLEEEGTLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKL 3677
E R + EE ++ L+++ E +N + KL Q +++ TL R+++
Sbjct: 2884 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2943
Query: 3678 KGLNDATTAAEEAEALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
L+ AE + VG ++ + L K + E + PL+ + VN L + L
Sbjct: 2944 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL 3002
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777
+ G L +E++N RW L V R+ QL EA
Sbjct: 3003 -TTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHEA 3041
Score = 194 bits (492), Expect = 3e-48
Identities = 469/2759 (16%), Positives = 1097/2759 (39%), Gaps = 318/2759 (11%)
Query: 1807 DEKLVSYLSLLRNIEMRTKQIQ--PLELNLAELQDLLCQAKVLERELKDLTTLVSQELEC 1864
++KL L E RT++++ PL +L +L+ + Q KVL+ +L+ V+
Sbjct: 454 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
Query: 1865 VNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQH 1924
V + S A ALE+ K L +++ R + Q+ +L +
Sbjct: 514 VVVVDESSGDHATA----ALEEQLKVLGDRWANICRWTEDRWVLLQD--------ILLKW 561
Query: 1925 TQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA 1984
+L AW+ K +N + D + + LQ+ LK + ++K + L
Sbjct: 562 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 621
Query: 1985 FDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV 2044
Q +S Q+ L + LE++ AQ+ +A+
Sbjct: 622 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS-----------QAVT 670
Query: 2045 KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 2104
T Q + + + + V E+ L H Q++L + + +I+ R
Sbjct: 671 TT---QPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDSEIRKR 723
Query: 2105 A----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQEETRV 2154
T + + E ++ + + +E + L+EK++ + E++ LQ+ +R
Sbjct: 724 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 783
Query: 2155 AQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLLTNLPG 2210
AQ +E+ V + ++ K +A+++L E + + L+W+ + L
Sbjct: 784 AQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQ 841
Query: 2211 MEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270
+EQ++ + + T P + Q ++ K L Q I +
Sbjct: 842 LEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERLKIQSI 895
Query: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKE 2328
L + G L + + +A K++QT+ D L ++ +
Sbjct: 896 ALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSA 950
Query: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
+W+++SE +L + E + L + + + L +++ + +++
Sbjct: 951 IRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM---- 1006
Query: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
K PSEI + + ++ R+ L S+ L + + + QN +L+
Sbjct: 1007 ----SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 1062
Query: 2449 WMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
WM A V+ L + D +L++QL KQ + +++ Q L V +I
Sbjct: 1063 WM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
Query: 2507 EGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2565
+ E P+ ET + + + + + R L+ + ++ S+Q+ L + + + +
Sbjct: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
Query: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 1176 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1235
Query: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRMLASGNQ 2684
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++ + N
Sbjct: 1236 LKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENI 1295
Query: 2685 PD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 1296 PGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LETFNSR 1350
Query: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
+ EL + R+K L+ + +ETE S+ + S++ ++KQ+
Sbjct: 1351 WRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--IDKQLA 1394
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
+ D A ++I TS E + +E +QGK +
Sbjct: 1395 AYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA--------------QR 1439
Query: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
+ Q + DV++K+ L ++ + + L + + E L LE+K
Sbjct: 1440 VLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALETKS-- 1492
Query: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2982
+ E V++Q L + +++ V + ++ ++ EN
Sbjct: 1493 ----------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKKQTENP 1538
Query: 2983 KKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
K++ E + + E+ R++QLE+ + + L WL ++ +
Sbjct: 1539 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1598
Query: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
+ P+ L+++ + KE E ++ + + E + + T G + V+ +L
Sbjct: 1599 AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVEDKLSL 1655
Query: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
+N W+ +T S+ ++ + +YQ+ ++ + V + + + + + E
Sbjct: 1656 LNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKK 1708
Query: 3160 KQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217
K Q +E ++++L + +V + L G D +K +E L
Sbjct: 1709 KPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQISELNHR 1763
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
+ RI +A++ ++ +Q +++ L+ P+ A+++ Q + E
Sbjct: 1764 FAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGVNLKEE 1810
Query: 3278 EFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 3336
+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L + R+
Sbjct: 1811 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1870
Query: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVE 3393
+ + + +Y+ +DL+ ++D + K++ L D +++ L + K LN V
Sbjct: 1871 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1930
Query: 3394 KRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL--EEMT 3449
++ L +A + + + I + A + A ++ +T + E+M
Sbjct: 1931 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1990
Query: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP----- 3504
+ ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 1991 LEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQS 2048
Query: 3505 --QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEG 3560
++D + + ++ A + ++ Q ++Q +F +V + + +E
Sbjct: 2049 SGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEK 2105
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEA 3618
+FH ++ +F+Q ++ I + + + + +++++ + + + + A
Sbjct: 2106 WRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2164
Query: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGRVEDFY 3674
+ E ++++ D L+ +L +LN + C +L++R K +EQ + + +F
Sbjct: 2165 TGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQ 2217
Query: 3675 RKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVN 3730
R L N+ EEA+ + + G E ++ ++L K+ +E PL+ L+Q+N
Sbjct: 2218 RDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLN 2271
Query: 3731 GLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+ + LE
Sbjct: 2272 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2331
Query: 3790 PL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
L L WL+ + P+ E +QE ++ + ++ V+ + ++
Sbjct: 2332 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVEEILSK 2385
Query: 3843 GGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------------ 3887
G + + E + + +LE L S W LL + A+Q L L
Sbjct: 2386 GQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2443
Query: 3888 -----VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEPVGTQT 3921
V+ K+ F+ ++D+LS+ ++ + + +
Sbjct: 2444 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2503
Query: 3922 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSE 3980
I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q ++ E
Sbjct: 2504 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2563
Query: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADH 4040
+Q+ + L++ L ++ + E + E L + KL S + D + ++ +
Sbjct: 2564 VQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITET 2623
Query: 4041 LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 4100
L +++ + NVD A LL+ + ++ + + I + I S+
Sbjct: 2624 KQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAA 2683
Query: 4101 LEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQKELKK 4154
LE+ +L +F E+ WL E E ++ + + + ++ ++L+
Sbjct: 2684 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2743
Query: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTIGQRVD 4208
E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 2744 EIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2798
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF------- 4261
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 2799 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2858
Query: 4262 ------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAI 4308
+++ +R + +++L+ E+ + T +L+++ E + ++E +
Sbjct: 2859 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2918
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEM 4367
+L +++ +++ + + E +EL + + + P + + L+ E++
Sbjct: 2919 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2978
Query: 4368 RQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
+ LR IA K ++ + + QL +L+P +E+ + + + +++ VRQ
Sbjct: 2979 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3037
Score = 184 bits (467), Expect = 2e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3831
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
Query: 3832 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3889
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 392 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 449
Query: 3890 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 450 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
+ + + L E++ L R++ I + LL L + E++
Sbjct: 510 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 569
Query: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 4066
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 570 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 629
Query: 4067 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 4113
+ V E D + + T S+A+ T + + T ++
Sbjct: 630 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 689
Query: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 4172
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 690 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 743
Query: 4173 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 4215
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 744 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 803
Query: 4216 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 4259
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 804 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 863
Query: 4260 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 4312
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 864 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921
Query: 4313 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 922 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
Query: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 4426
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 982 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1031
Query: 4427 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 4472
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 1032 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1085
Query: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 1086 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1141
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 1142 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1201
Query: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 1202 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1261
Query: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4708
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 1262 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321
Query: 4709 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4768
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 1322 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
Query: 4769 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1428
Query: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888
K + + A + S+++ + + V K Q+ F +++
Sbjct: 1429 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1474
Query: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4948
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 1475 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1533
Query: 4949 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 5008
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 1534 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1593
Query: 5009 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 5068
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 1594 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1652
Query: 5069 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 5099
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 1653 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1712
Query: 5100 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 5129
+ K+L L D +DS + ++N D
Sbjct: 1713 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1772
Query: 5130 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 1773 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1832
Query: 5188 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 5233
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 1833 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1891
Query: 5234 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 5287
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 1892 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1949
Query: 5288 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 5347
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 1950 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2006
Query: 5348 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 2007 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2066
Query: 5396 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 5444
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 2067 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2126
Query: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5504
L + IP+N + K ++ +++E+ V +T
Sbjct: 2127 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2163
Query: 5505 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5564
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 2164 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2216
Query: 5565 KEFANFDFDVW 5575
+ N +F +W
Sbjct: 2217 QRDLN-EFVLW 2226
Score = 91.3 bits (225), Expect = 3e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 5087 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 5146
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 331 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 390
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 391 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
Query: 5206 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 5263
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 451 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
Query: 5264 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 5322
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 509 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 568
Query: 5323 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 5380
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 569 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 627
Query: 5381 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 5437
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 628 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 687
Query: 5438 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 5494
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 688 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 741
Query: 5495 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5554
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 742 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 797
Query: 5555 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5614
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 798 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 853
Query: 5615 LASKFPTTKLEMTAV 5629
PTT E TA+
Sbjct: 854 --KIQPTTPSEPTAI 866
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 340 bits (871), Expect = 3e-92
Identities = 667/3723 (17%), Positives = 1479/3723 (39%), Gaps = 418/3723 (11%)
Query: 1887 DAKNLQKSLSSVSDTW------NSRLLHFQNAVEIEKTKVLN---QHTQLEGRLQDLRAW 1937
D K L K+L + D +L H + E+ K + + Q TQ+E + D+ W
Sbjct: 2260 DLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTW 2319
Query: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997
L + N + L++ +D+++ + +++ IS ++
Sbjct: 2320 FTKVEESLMNCAQNETCEA------LKKVKDIQKELQSQQSN-----------ISSTQEN 2362
Query: 1998 LSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQ 2057
L+ + L L R+ ++++ A V L Q QE+L K +
Sbjct: 2363 LNSLCRKYHSAELESLGRAMTGLIKKHEA-VSQLCSKTQASLQESLEKHFS-------ES 2414
Query: 2058 LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEG 2117
+++ W A+ A RT D L+ DL+++ D + + + V
Sbjct: 2415 MQEFQEWFLGAKAAAKESSDRTG--DSKVLEAKLHDLQNILDSVSDGQSKLDAVT----- 2467
Query: 2118 FMEENQT---KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKS 2174
+E QT LS + +++++E++ +A E+++A ++ ++ L++ + E +
Sbjct: 2468 --QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHR 2525
Query: 2175 KA------------AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222
K + L E+K+ I + V V G+LL +++LS ++G
Sbjct: 2526 KLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLS----QRG 2581
Query: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282
L + +G+ G Q + C + HQ LL + + +S Q L +H E
Sbjct: 2582 QLLSEEGH-GAGQE----GRLCSQLLTSHQNLLRMTKEKL---RSCQVALQEH------E 2627
Query: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 2342
+ Q + + LA +E+ L TL+ L + +QD
Sbjct: 2628 ALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ-IQDIL--------------- 2671
Query: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402
L+K +G ++ KG+ + +S KEG+
Sbjct: 2672 -------------LMKGEGEVKLNMAIGKGEQA-----------LRSSNKEGQR------ 2701
Query: 2403 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 2462
+++ +L+ E + + S S L ++ Q++ + + L+ WM++ + +E L
Sbjct: 2702 VIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ 2761
Query: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
PG L+E+ LQ L+E + L ++ E+ E D +
Sbjct: 2762 P----QPG-LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY-EKTEDESFKDTAQE 2815
Query: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
+ + F + E+ +++ + +++ + ++ L S S
Sbjct: 2816 ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSA 2875
Query: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQ 2635
Q+ L+ K+K+ I ++ + + E +TTA+ +Q A+ Q
Sbjct: 2876 TQKKLS---KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ 2932
Query: 2636 RFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS---------GNQPD 2686
+ + Q E+ + ++ + F +L+Q +E S +L + G D
Sbjct: 2933 WEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD 2992
Query: 2687 QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTEL 2746
++I + + QE+ ++ + + L+ + EL C F+ DL + +V L K++ L
Sbjct: 2993 EEIVECWHKGQEILDALQKAEPRTEDLKSQLNEL--CRFSRDLSTYSGKVSGLIKEYNCL 3050
Query: 2747 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLK 2805
+ ++ +Q FRK R FQ+WL + + + + E+ ++ ++
Sbjct: 3051 CLQASKGCQNKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQ 3108
Query: 2806 SLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCK 2865
L + + + + KG L L+ + A Q K V ++ +H+
Sbjct: 3109 EFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAK-------VTAAKEDWKNFHSN- 3160
Query: 2866 DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL-- 2923
LH+++ +L+ + +M++ A + WL E+++
Sbjct: 3161 ----------------------LHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHE 3198
Query: 2924 KSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWK 2983
S P K + + + ++ L E+ P++ ++KE L + +++++
Sbjct: 3199 SSNRLYDLPAK----RREQQKLQSVLEEIHCYEPQLNRLKEKAQQL---WEGQAASKSFR 3251
Query: 2984 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043
+L+S++ + +T + +L+ + F +L+ W+ + M+ +
Sbjct: 3252 HRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTS 3311
Query: 3044 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQK 3103
D ++L+++ +++ +L + + Q + + + +L + T +Q++LQS+
Sbjct: 3312 DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDM 3369
Query: 3104 WVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQL 3163
W L SQ++ A+ K T YQ+ ++ S + ++ L+ + E +L
Sbjct: 3370 WASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAEL 3422
Query: 3164 EETSEIRSDLEQLDHEVKEAQTLCDELSVL---IGEQYLKDELKKRLETVALPLQGLEDL 3220
+ + + + L+ EV +L + + V + E Y+ + L+ + + +++
Sbjct: 3423 RDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT---QLELQDLQERYRAIQER 3479
Query: 3221 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 3280
A + + + + + Q++Q+ WL +Q + + + ++ L++ +E Q
Sbjct: 3480 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3539
Query: 3281 KSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKD 3340
+ ++ E ++ S P E R L++ L+ W+ + ++ +++ +
Sbjct: 3540 VHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES----LRQDWQAYQHRLSETRTQFNN 3595
Query: 3341 CMQKAQKYQWHVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLL 3399
+ K + + + + W++ + K+S R + E L + K EV R +
Sbjct: 3596 VVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEV 3655
Query: 3400 EILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEE-------LQAKTGSLEEMTQRL 3452
E + + A +++ S + + + + A+ + L+ + SLEE L
Sbjct: 3656 EEVGARAQEILDESHVNSR-MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSL 3714
Query: 3453 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3512
+ + + + K + +++ D + K L+ L + ++ + R
Sbjct: 3715 SSYSDWYGSTHKNFKNVATKIDKVDTV----MMGKKLKTLEVLLKDMEKGHSLLKSAREK 3770
Query: 3513 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3572
+ V+ +G +A +L + ++ E+ V + +E L +F + + +
Sbjct: 3771 GERAVKYLEEG-EAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
Query: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EG 3631
+A+ + L + + ++ + + L+K L+ + + E + + E+ E
Sbjct: 3830 QWIAEYQEIL-------HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3882
Query: 3632 TLDLLG---LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLND-ATTAA 3687
L+L+ LK +++ L L GK LE + ED+ +L+ + +
Sbjct: 3883 LLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMS 3942
Query: 3688 EEAEALQWVVGTEVEIINQQLADFKMFQKE------QVDPLQMKLQQVNGLGQGLIQSAG 3741
A + + +E I QQLA K +E +++ LQMK + G +Q+
Sbjct: 3943 GRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKL 4002
Query: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQ-LQEALLHCGKFQDALEPLLSWLADTE- 3799
K L+ + +A +T AQR+ Q L+ L QD L+ +WL+ +
Sbjct: 4003 KQNVHAHLQGTKDSYSAICST-----AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 4057
Query: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
+L + +PP + + +K Q++ + LQ + + +D+L + D +
Sbjct: 4058 DLEPSPQPPLSRAEAIK-QVKHFRALQ---EQARTYLDLL----------CSMCDLSNAS 4103
Query: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919
+ + + + TE + +E LV A+ + E I S L +++
Sbjct: 4104 VKTTAKDIQQTE---------QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ--- 4151
Query: 3920 QTAKIQQQIIRHKALEEDI-ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQA 3976
++Q RH LE +I +N + V VK QS + + + V L++K +S +
Sbjct: 4152 ---QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEH 4208
Query: 3977 R-YSEIQDR---CCRKAALL----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
+ + + D+ CR++ L ++ L R + + V +L + + ++ D
Sbjct: 4209 KEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDA 4268
Query: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYA 4088
+ +H + LAL + RK ++ Q +++ ++ L++E+ ++ R+
Sbjct: 4269 ESTAVHLEALKKLAL--ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWF 4326
Query: 4089 DITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQR 4148
+ + ++ + QS ++EL W E + +A + QSP +
Sbjct: 4327 QLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMD 4386
Query: 4149 QKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVD 4208
+ E+ +++L ++ + + ++ + R+ + K +SDA +SD +GQR
Sbjct: 4387 HLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRK 4446
Query: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 4268
++ A+ Q+ A + + + +RK+M I L D + Q++ K+ + +
Sbjct: 4447 YLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTY 4506
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
++ + L++ E+ E++K+ + K + L Y+++ S R LE+ V
Sbjct: 4507 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4566
Query: 4329 FWETYEELSPWIEETRALIAQLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLK 4386
F E +++ W+++ A I P + +E +L Q + + + E E++ + L +
Sbjct: 4567 FKEDFDKACHWLKQ--ADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQR 4624
Query: 4387 IGPQ-LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIE 4445
G L LN + + EK + I + + + EA+ E+ IE
Sbjct: 4625 TGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIE 4681
Query: 4446 PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG- 4504
++L L ++ +P ++ + E +S L+++ EA+ ++ G
Sbjct: 4682 LTTQSLSELEAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
Query: 4505 RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALL 4561
RS G DK+ +V + +K + E+R D + EK + L
Sbjct: 4741 RSTGQPWQ------PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQL 4794
Query: 4562 TTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGE 4621
++K+ Q V++ P +++++ ++ L+ + I DL
Sbjct: 4795 KSVKEEQSKVNEETLPA------EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDP 4848
Query: 4622 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4681
+ R I + L E + + E M ++ +Q + DWL +K
Sbjct: 4849 LAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAE 4906
Query: 4682 TMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDI 4736
PV DLN ++D E++ K++++Q++++ M L+H+ + KA + D
Sbjct: 4907 LSGPVYLDLN-LQDIQEEIR--KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD- 4962
Query: 4737 IREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI 4796
+ L EL L ++ E + RQ L ++ + WL +ELL +
Sbjct: 4963 LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----L 5018
Query: 4797 SG---DPKVIEVELAKH----------HVLKNDVLAHQATVETVNK-AGNELLESSAGDD 4842
+G D + E L H H ++ + AT++ + K G E LE
Sbjct: 5019 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA-- 5076
Query: 4843 ASSLRS-RLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSA 4901
+ LRS R+ + +LQ+ + Q ++ ++ E L E + +++ S
Sbjct: 5077 SLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS- 5135
Query: 4902 SKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA 4961
A E+L H L S + + E L +K + + +D+ S + +S+
Sbjct: 5136 --------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMT 5186
Query: 4962 LLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNT 5021
+ Q+W + + ++++ LE+A++ T F N +++ + + L +S
Sbjct: 5187 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5246
Query: 5022 VLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-------------IKNL 5068
+L+ +E H F ++EL+Q + L L Q+ +L +
Sbjct: 5247 LLTLLEYHDTF----------VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5296
Query: 5069 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISND 5127
+ ++Q R + ++ G+ + K + + W+++ + +L + +EI
Sbjct: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
Query: 5128 PDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGE 5181
+++++ L++ ++ + + KEK T+LP + S +L +
Sbjct: 5357 LEELQILLTEATNHRQNIE----------KMAEEQKEKYLGLYTILPSELSLQLAEVALD 5406
Query: 5182 VRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 5241
++ + D + K E + + S Q + L L K++ + D V
Sbjct: 5407 LKIR-DQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK----------TDNV 5455
Query: 5242 MNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLS 5301
+ KV +EL + L + ++ +E + + ++ +L+ + +
Sbjct: 5456 VQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQA 5515
Query: 5302 VSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMK 5361
++ S+L QA E + + + ++L+W+ +A + L + L+ H+ ++
Sbjct: 5516 ENRLSKLNQAASHLEEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE 5574
Query: 5362 KVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL 5421
E K +D + AM E + + C + + + EE+ K Q L+ A
Sbjct: 5575 --ESKEID-SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA 5631
Query: 5422 SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDV 5481
++ L++L A ++ A+ TL + + +K ++ Q + EM +P V
Sbjct: 5632 KDMKKFEAELKKLQAALEQAQATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKV 5686
Query: 5482 DRV 5484
V
Sbjct: 5687 QAV 5689
Score = 310 bits (794), Expect = 3e-83
Identities = 678/3931 (17%), Positives = 1530/3931 (38%), Gaps = 460/3931 (11%)
Query: 1879 QLLKAL--EKDAKNLQKSLSSVSDTWNS--RLLHFQNAVEIEKTKVLNQHTQLEGRLQDL 1934
+LL L ++ AK +Q +++ + W + LH Q +E K+ Q E + +
Sbjct: 3129 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH-QKESALENLKI--QMKDFEVSAEPI 3185
Query: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEH 1994
+ W+ +++ + SN D+ + Q+ + + + + + QL+ L E
Sbjct: 3186 QDWLSKTEKMVH-ESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL--------KEK 3236
Query: 1995 AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC 2054
AQ L Q +SF+ + Q ++Q AL + E+ + + + + N
Sbjct: 3237 AQQLWEGQ---------AASKSFRHRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHNQF 3285
Query: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD 2114
+++L W+ A L + T+ D S L L+ L Q + +V
Sbjct: 3286 SLGIKELQDWMTDAIHMLDSYCHPTS--DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTR 3343
Query: 2115 IEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTS-------AL 2167
E ++ SP + ++++L K+ + +L + +LE A++
Sbjct: 3344 GESVLQNT----SPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR 3399
Query: 2168 QQETEKSKAAKELAENKKKIDALLDWVTSVGSS---GGQLLTNLPGME--QLSGASLEKG 2222
Q L E++++ L D T +G + ++L+ +E ++ GA + +
Sbjct: 3400 QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEH 3459
Query: 2223 AL------DTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ-- 2274
+ D + Y + + ++ + E + HQE + F + Q LDQ
Sbjct: 3460 YVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYS 3519
Query: 2275 ------HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSE---------AELKQVQTLQDEL 2319
H H T + Q LQ E + ++ L E AE + +++L+ +
Sbjct: 3520 VLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDW 3579
Query: 2320 QKFL---------------------QDHKEFESWLERSEKELENMHKGGSSPETLPSLLK 2358
Q + Q ++ + WL+ +E+++ + S+ T L
Sbjct: 3580 QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLH 3639
Query: 2359 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 2418
+ + E+V +++ ++ V Q++LD S + + + + T RY AL
Sbjct: 3640 QMKKWHEEVTAYRDEVEEVGARAQEILD----------ESHVNSRMGCQATQLTSRYQAL 3689
Query: 2419 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 2478
+ L + + ++S S W + N + + + D ++ ++L T
Sbjct: 3690 LLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKT 3749
Query: 2479 TKQLQEELAE-HQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537
+ L +++ + H + +K R + +E A +++ + + L+ ++ +
Sbjct: 3750 LEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA---ERLRKEIHDHMEQLKELTSTVRK 3806
Query: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
L+K + ++ + ++L Q I E ++ L + + + L+ L+Q +
Sbjct: 3807 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTV 3866
Query: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQ 2657
+ S+++ RE +E T L+ K+ ++ ++ LC +E SL+ +
Sbjct: 3867 LSHEPSVKSVREKGEALLELVQDVT---LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKD 3923
Query: 2658 AEMFEHLSGKLQQFMENKS-RMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHL 2716
E + ++++++ S R++A + QQ+ ME+ D L +L
Sbjct: 3924 HEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNL 3983
Query: 2717 V----TELSSCGFALDLCQHQD---RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK 2769
T + C L Q+ +Q + ++ + T + + ++ +
Sbjct: 3984 QMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQD 4043
Query: 2770 LVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSL 2828
++ Q WL + + P+ + +S E KQ++H ++L + + ++ C L
Sbjct: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE----QARTYLDLLCSMCDL 4099
Query: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL-TEIQCDMSD----------- 2876
N ++ TA D Q +I + + G+ K L +E+ + D
Sbjct: 4100 SNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRR 4159
Query: 2877 -----VNLKYEKLGGV------LHERQESLQAILNRMEEV--------HKEANSVL-QWL 2916
+N+ + V L +Q S+ I+ ++ ++ HKE N + QWL
Sbjct: 4160 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4219
Query: 2917 E-----------SKEEVLKSMDAMSSPTKTET------------VKAQAESNKAFLAELE 2953
+ +E++ ++ D E ++ AES L L+
Sbjct: 4220 DLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALK 4279
Query: 2954 QNSPKIQKVKEALAGL------LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQL 3007
+ + +Q+ K A+ L ++ + N + E K+ L RW + ++ + +
Sbjct: 4280 KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVS 4339
Query: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQ 3067
+ L Q+ +L W E++ + S P+M + E EA++
Sbjct: 4340 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4399
Query: 3068 QHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE-LTDKLNSRSSQIDQAIVKST 3126
+ L + A ++ D+ L+ QV ++ S Q V L+D + R +++A+ + T
Sbjct: 4400 LLKSLIKDADRVMA---DLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKT 4456
Query: 3127 QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTL 3186
Q+ + + +++ +++ + I P+ V +Q++ ++ L+ +EV
Sbjct: 4457 QFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQ 4516
Query: 3187 CDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELR 3246
EL + EQ K E+ +L+ + + + R+ L+ L S + F++ FD+
Sbjct: 4517 GRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKAC 4575
Query: 3247 TWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP 3306
WL + + L +QL + + + ++ + G+++L S+
Sbjct: 4576 HWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNE 4635
Query: 3307 GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM 3366
+ L +L L + + D+ ++++ + ++Y +E + + +A+
Sbjct: 4636 VDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQF 4694
Query: 3367 SELRVTLDPVQLESSLLRS---KAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDE 3423
+ + +E +L +A+L+EV ++ LN + ++ + +
Sbjct: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4754
Query: 3424 KAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQA 3483
+ + TE+ + LE+ T +E ++ + +E++++ K + Q+
Sbjct: 4755 LVTLYHRLKRQTEQ---RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE---------QS 4802
Query: 3484 CSNKNL----EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP--DGSDASQLLHQAEVAQ 3537
N+ EKL+ + +L+ L+ T L + AP D + HQ + Q
Sbjct: 4803 KVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQ 4862
Query: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
E + + E+++ F + L + EL G + + +Q
Sbjct: 4863 GELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE 4922
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK 3657
+I +++ ++ + A + + + L L+ L L++ G + E +
Sbjct: 4923 EIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALR 4982
Query: 3658 ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKE 3717
RQ L + + +Y+ + ND A+E L G +VE + L F
Sbjct: 4983 TRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESAEENLKSHMEFFST 5041
Query: 3718 QVDPLQMKLQQVNGLG---QGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQL 3774
+ D L++++ L LI+ GK+ LE + + R +++ ++ L
Sbjct: 5042 E-DQFHSNLEELHSLVATLDPLIKPTGKE----DLEQKVASLELRSQRMSRDSGAQVDLL 5096
Query: 3775 QEALLHCGKFQDALEPLLSWLADTEELIAN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRK 3833
Q +Q A E ++ + DTE+ ++ ++ + ++ E K L +++
Sbjct: 5097 QRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFH 5156
Query: 3834 ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893
+ L+ + ++ ++ A + ++ + ++ RWT L + A ++K LED + F
Sbjct: 5157 EKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGF 5216
Query: 3894 HETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQ 3953
+ + ++ + + KL S A++ + H ++E + + + Q
Sbjct: 5217 NNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ--Q 5274
Query: 3954 SLSSLT-----SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008
+LS L +P E+ L ++I ++Q R +Q++ L+ Q L + +
Sbjct: 5275 TLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINS 5334
Query: 4009 VLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT 4068
V W+ E ++ L + ++ + Q + L E N ++N++ K + ++
Sbjct: 5335 VKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQNIE---KMAEEQKEKY 5385
Query: 4069 TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 4128
G +L E + + A++ + K ++ + + ++T +EL+ ++++ ++
Sbjct: 5386 LGLYTILPSE----LSLQLAEVAL-DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKD 5440
Query: 4129 LATSGGQ-SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN----EVSRALLELVPWRARE 4183
L T + + + Q + QK L +E LD N E+ A+ + + +
Sbjct: 5441 LTTILTKLKAKTDNVVQAKTDQKVLGEE-------LDGCNSKLMELDAAVQKFLEQNGQL 5493
Query: 4184 G--LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241
G L K + E ++ R+ +++ A ++Y + + L W+ K K++A
Sbjct: 5494 GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAH 5551
Query: 4242 GPI------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ 4295
G I +L + Q ++++ ID ++M E + + ++ C E+ +
Sbjct: 5552 GTIAWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSVY--CTEK----MS 5603
Query: 4296 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI 4355
++ L ++ E + + R L+ A + +F ++L +E+ +A L SP +
Sbjct: 5604 QQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEV 5660
Query: 4356 DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYA 4414
L++Q + L + KP + + L+ + + + + +
Sbjct: 5661 GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEAS 5720
Query: 4415 QIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIREC 4474
+++ Q+ + AV Q Q + +++ + + +E + P+ + + +++
Sbjct: 5721 RLQHTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQ 5777
Query: 4475 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKA 4534
IS ++ +++ Q +L + + L +++ A L E++ + ED+
Sbjct: 5778 ISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDG 5833
Query: 4535 RAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP--------------GID 4580
V+ + + + + +T + ++ SP ++
Sbjct: 5834 ELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVN 5893
Query: 4581 PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4640
I Q +AE ++ + +H + + G +P + ++ +WE
Sbjct: 5894 QDIAYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSATAKLGDLQRSWET 5946
Query: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEM 4700
L E+ L +A++ +YQD+LQ++ ++ +KL P G + + Q+ E
Sbjct: 5947 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG---RSPESQMAEH 6003
Query: 4701 KEFKVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAH 4757
+ E+ Q E+ +L E ++ ++ D ++ ++ LT L + K +
Sbjct: 6004 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASG 6063
Query: 4758 RQHKLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVEL 4807
++ LE L AL +++ +EL SWL T+ LD +P +E +L
Sbjct: 6064 KRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQL 6123
Query: 4808 AKHHVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRSRLEAMNQCWESVL 4861
+N ++ + V +++ N LLE A D+A L +L + +
Sbjct: 6124 MD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ 6180
Query: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921
+ +++ +Q T Q+ + S+++ + ++ L+ ++ T + + L E
Sbjct: 6181 RALHDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKE 6236
Query: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKL 4981
L +L ++ + +G +L+ + + + +L Q+ ME KS
Sbjct: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSA 6291
Query: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041
E+ + + ++++ QEF S +L VL Q +E +++ +
Sbjct: 6292 EDQMRM--KWESLHQEF--------------STKQKLLQNVLEQEQEQVLYSRP-----N 6330
Query: 5042 QIIELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100
+++ +G L K QD + +LL + +E+V S + G + + ++
Sbjct: 6331 RLL----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKL 6383
Query: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGR 5160
++ WL+D E L + P++ + L + K + D
Sbjct: 6384 YDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMSEEMD------- 6434
Query: 5161 ALKEKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
K K L PE+ D LG + V + + + +L++ L F
Sbjct: 6435 --KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQND 6492
Query: 5210 FMDALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 5267
+L D Y + +LA +QPV ++ + D K F G +++ +R
Sbjct: 6493 LKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD------AGIIELKRR 6546
Query: 5268 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
+ +E +L +L +D + + S++S L Q L + + L +
Sbjct: 6547 GDKLQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6600
Query: 5328 WLSEAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHP 5386
L ++ + + + E +Q L+D HKE+ + +E +
Sbjct: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI------------------ 6642
Query: 5387 DCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAELLEELLAWI--QW 5440
+ F +++++A Q + + T L S ++ A L +I W
Sbjct: 6643 -----------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETW 6691
Query: 5441 AETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPF 5500
+ + DQ+ + + ++ V++ I E R +DR+T K+ + P
Sbjct: 6692 SH---LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPK 6745
Query: 5501 IEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDR 5560
+ + G++ L +S S+ ++ ++NQL W L K++ L R
Sbjct: 6746 LYQVLDDGKRLLIS--------ISCSDLES-QLNQLGECW-------LSNTNKMSKELHR 6789
Query: 5561 LEE-LKEFANFDFDVWRKKYMRWMNHKKSRV 5590
LE LK + + + + W+ K R+
Sbjct: 6790 LETILKHWTRYQSE--SADLIHWLQSAKDRL 6818
Score = 310 bits (793), Expect = 4e-83
Identities = 697/3904 (17%), Positives = 1490/3904 (38%), Gaps = 489/3904 (12%)
Query: 1857 LVSQELECVNQIIISQPQEVPAQ--------LLKALEKDAKNLQKSLSSVSDTWN---SR 1905
L + L+ + ++ + P P + LK L + + L D W SR
Sbjct: 1073 LCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSR 1132
Query: 1906 LLHFQNAVEIEKTKVLN---------QHTQLEGRLQDLRAWVGNKNLILNSKGSNSEI-- 1954
F + + +T++ H +++ ++++R V + L+ S ++
Sbjct: 1133 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLT 1192
Query: 1955 DVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHA-----QDLSPQQNRQMLRL 2009
+V S N +Q ++L + + KA + L+ +++ +S +++ +++
Sbjct: 1193 EVSSENEAQKQGDELAKLSSSFKALVTLLS-EVEKMLSNFGDCVQYKEIVKNSLEELISG 1251
Query: 2010 LNELQRSFQDILE-QTAAQVDALQGHLQQMEQEALVKTLQKQQNTC-------------H 2055
E+Q + IL+ + + L H QQ + K QQ H
Sbjct: 1252 SKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGH 1311
Query: 2056 QQLEDLCSWVGQAERALAGHQGR------------TTQQDL-----------------SA 2086
++L L S + ER+ + R T ++ + S+
Sbjct: 1312 EELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSS 1371
Query: 2087 LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYE 2146
L+ S+L+ ++ R S A +++ E ++ L P+ L+++ KEQ +
Sbjct: 1372 LESLSSELEQTKE-FSKRTESIAVQAENL--VKEASEIPLGPQNKQLLQQQAKSIKEQVK 1428
Query: 2147 ALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206
L++ LEE + + +T+ + L W+T
Sbjct: 1429 KLED-------TLEEDIKTMEMVKTKWDHFG-------SNFETLSVWITE---------- 1464
Query: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQ 2266
E AL+T+ M D Q +K QE+ S+ + + +
Sbjct: 1465 ----------KEKELNALETSSSAM---------DMQISQIKVTIQEIESKLSSIVGLEE 1505
Query: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSE--------AELKQVQTLQDE 2318
AQ+F +T E ++ KL +++ +Y L + L Q Q ++
Sbjct: 1506 EAQSF----AQFVTTGESARIKAKLTQIR-RYGEELREHAQCLEGTILGHLSQQQKFEEN 1560
Query: 2319 LQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVT 2378
L+K Q EFE L K S+ ET +L+ + + S + +
Sbjct: 1561 LRKIQQSVSEFEDKLAVPIKIC------SSATETY-KVLQEHMDLCQALESLSSAITAFS 1613
Query: 2379 ISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ 2438
S +KV++ ++ +E + + +D L+ A ER TAL + LL + +
Sbjct: 1614 ASARKVVNRDSCVQEA---AALQQQYEDILRRAKERQTALEN-----------LLAHWQR 1659
Query: 2439 FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQK 2498
+ S W++ EA D +++D ++ +L + LQ E+ KL +
Sbjct: 1660 LEKELSSFLTWLERGEAKASSPEMD-ISADRVKVEGELQLIQALQNEVVSQASFYSKLLQ 1718
Query: 2499 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES 2558
+ + + + D + ++ + + ++ L + +R + LQ +A+ Q E L S
Sbjct: 1719 LKESLFSVASK--DDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1776
Query: 2559 LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETA 2618
I L+ S +S Q AL + ++ +K L++ + + +
Sbjct: 1777 FSVWIKLFLSELQ--TTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG 1834
Query: 2619 DSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRM 2678
+ +LQGK + Q FE+ + ++ +L L + LSG L+Q +
Sbjct: 1835 RAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQ-LRQTVEA 1893
Query: 2679 LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTEL------------------ 2720
S N+ + D+ + ++ D +N LE L
Sbjct: 1894 TNSMNKNESDL---------IEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQ 1944
Query: 2721 -SSCGFALD-LCQHQDRVQN--------------LRKDFTEL------------QKTVKE 2752
+SC D LC +R+QN L+K F + ++T KE
Sbjct: 1945 RTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKE 2004
Query: 2753 REKDAS--SCQEQLDEFRKLVRTFQK------WLKETEGSIPPTETSMSAKELEKQIEHL 2804
R K+ + + Q++L F +L WLK+ I + + A E++++I L
Sbjct: 2005 RLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAF-APEVDREINRL 2063
Query: 2805 KSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTC 2864
+ DD L+ E + L +L+ E + + +L + S + + T
Sbjct: 2064 EVTWDD---TKRLIHENQGQCCGLIDLMREY--QNLKSAVSKVLENASSVIVTRT---TI 2115
Query: 2865 KDLTEIQCDMSDVNLKYEKLGGVLHERQESL-------QAILNRMEEVHKE--------- 2908
KD +++ S K+E ++ +Q+ L + +L+ ++++H
Sbjct: 2116 KDQEDLKWAFS----KHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDM 2171
Query: 2909 ANSVLQWLESKEEVLKSMDAM-----------------------SSPTKTETVK------ 2939
++V +WL+ E++ ++MD + P E +
Sbjct: 2172 ESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL 2231
Query: 2940 AQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV 2999
E K F +E++ + +++++ + L N + + + I+ +L + E A E+
Sbjct: 2232 RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEI 2291
Query: 3000 TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLN-AQKQQVQFM 3058
T + L++ + + + + W + ++ +++N AQ + + +
Sbjct: 2292 TEVAKGTLKDFTAQSTQVEKFINDITTWFTK------------VEESLMNCAQNETCEAL 2339
Query: 3059 LKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDK---LNSRS 3115
K + +++ Q + + T SL EL+S+ + L K ++
Sbjct: 2340 KKVKDIQKELQSQQSNISS---TQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2396
Query: 3116 SQIDQAIVKSTQ--YQELLQDLSE---KVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR 3170
S+ ++ +S + + E +Q+ E +A + S ++ S EA L+ +
Sbjct: 2397 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSV 2456
Query: 3171 SD-LEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 3229
SD +LD +E QTL LS I + K E A Q L+D A LQ
Sbjct: 2457 SDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQA-----LQ 2511
Query: 3230 AALASTQQFQQMFDELRTWLDDKQSQ-QAKNCPISAK-LERLQSQLQENEEFQKSLNQHS 3287
+ F+ +L W+ + + + +N S + + ++++ + E F L
Sbjct: 2512 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2571
Query: 3288 GSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQK 3347
S + + G+ L ++ L +QL L +H + L + T ++ + +Q+ +
Sbjct: 2572 ESLDKLSQRGQLLSEEGHGAGQEGRLCSQL--LTSH-QNLLRMTKEKLRSCQVALQEHEA 2628
Query: 3348 YQWHVEDLVPWIEDCKAKMSELRVTL---DPVQLESSLLRSKAMLNEVEKRRSLLEILNS 3404
+ ++ + W++ + +++ TL D ++ S ++ +L + E L +
Sbjct: 2629 LEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD-ILLMKGEGEVKLNMAIGK 2687
Query: 3405 AADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEK 3464
L +S++ + I+ + + + + +LE + + ++ E +E+
Sbjct: 2688 GEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ 2747
Query: 3465 KVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF---TQGLVEDAP 3521
+E ++E L Q + L Q +L E L ++ L E
Sbjct: 2748 WMESVDQKIE--HPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTE 2805
Query: 3522 DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHC----RVREMFSQLAD 3577
D S + AQ+E + + K+E I + H V E L
Sbjct: 2806 DES-------FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHS 2858
Query: 3578 LDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV--------------LKLDIEASEAEC 3623
+EL + D+ + Q ++ ++ ++ + +K + AS E
Sbjct: 2859 AKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCEL 2918
Query: 3624 RHMLEEEGTLD-------LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK 3676
H + D + + LE L Q + + QLE L E F
Sbjct: 2919 MHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQAL---EQFSAL 2975
Query: 3677 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
LK T E + +V E Q++ D + + + L+ +L ++ + L
Sbjct: 2976 LKTWAQQLTLLEGKNTDEEIV--ECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDL 3033
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796
+GK V GL ++E N +K + LQ+ +F+ A WL
Sbjct: 3034 STYSGK---VSGL---IKEYNCLCLQASKGCQNKEQILQQ------RFRKAFRDFQQWLV 3081
Query: 3797 DTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE 3856
+ + A V +Q+ + ++ + ++M+ ++G ++ +
Sbjct: 3082 NAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAK 3141
Query: 3857 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL-ANSE 3915
I ++ + + W S ++ LE++ + K F +AEPI D+LS TEK + +S
Sbjct: 3142 GIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSN 3201
Query: 3916 PVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQ 3975
+ AK ++Q LEE I + +++ + Q L A ++ L
Sbjct: 3202 RLYDLPAKRREQQKLQSVLEE-IHCYEPQLNRLKEKAQQL--WEGQAASKSFRHRVSQLS 3258
Query: 3976 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 4035
++Y + + K + LD+ ++ F E+ +W+ + L S + VL
Sbjct: 3259 SQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDS 3318
Query: 4036 QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSS 4095
+ AL ++ + + G+++L+ T+ E + IQ++L +K +A +
Sbjct: 3319 RTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGI 3378
Query: 4096 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155
+ LE A T +Q + +GW+ +E L S Q + K L +E
Sbjct: 3379 RCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEE 3438
Query: 4156 VMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ 4215
V+ + +L+T+ + E + + D E+Y+ + + + V + + ++
Sbjct: 3439 VLSYSSLLETIEVKGAGMTEHYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVR 3492
Query: 4216 RSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDEL 4275
Q+Y++ A W+ + + KL + + L+ + + + ++ +
Sbjct: 3493 LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSV 3552
Query: 4276 FSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
R ++ G E + + ESL Q ++A SE + + + +
Sbjct: 3553 LHTREDVIPSGIPQAEDRAL-----ESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKF 3607
Query: 4334 EELSPWIEETRALIAQLPSPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLK 4392
+++ W++ + SP + R +E ++ Q+++ E + D++ ++G + +
Sbjct: 3608 QQVDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQ 3663
Query: 4393 EL------NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP 4446
E+ N G + + + + Q+ E+++ + + ++ + D
Sbjct: 3664 EILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3723
Query: 4447 MLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVE-----LEKLQPSFEALKRRGEE 4501
+ +N++++ +DK+ + K T+E +EK ++ + +GE
Sbjct: 3724 THKNFKNVATK----------IDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
Query: 4502 LIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALL 4561
+ + + + KEI D ++Q+ +++ + + + L LA++F AL
Sbjct: 3774 AVKYLEEGEAERLRKEIHDHMEQL----KELTSTVRKEHMTLEKGLHLAKEFSDKCKALT 3829
Query: 4562 TTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGE 4621
I + Q+I+H E P ++ K Q+ +++++ ++ +R G L+
Sbjct: 3830 QWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL--- 3886
Query: 4622 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4681
+ ++ ID++ + +++L KE + LE ++ Y LQ + WL +L
Sbjct: 3887 VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLV 3946
Query: 4682 TMPPVGT-DLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI---I 4737
+ T L T+ QL K E+ + + L +G+ ++ + D + +
Sbjct: 3947 APDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNV 4006
Query: 4738 REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD--AQRP 4795
L K + + LE L Q L++ +WL+ + L+ Q P
Sbjct: 4007 HAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP 4066
Query: 4796 ISGDPKVIEVELAKH-HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRS------ 4848
+S + ++ KH L+ + + ++ N ++++A D + ++
Sbjct: 4067 LS---RAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLV 4123
Query: 4849 RLEAMNQCWESVLQKTEEREQQLQSTLQQAQGF---HSEIEDFLLELTRMESQLSASKPT 4905
+ + + Q WE + E LQ QQ Q HSE LEL ++ +S K
Sbjct: 4124 QAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSE-----LELNIAQNMVSQVKDF 4178
Query: 4906 GGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ 4965
++ + ++T +E ++L KEE S + +Q + L Q
Sbjct: 4179 VKKLQSKQASVNTIIEKVNKLTKKEE--------------SPEHKEINHLNDQWLDLCRQ 4224
Query: 4966 KWHVVSSKME--ERKSKLEEALNLATEFQNSLQEF-INWLTLAEQSLNIASPPSLILNTV 5022
++ + E +R + +N+ F L++F W LA + L +
Sbjct: 4225 SNNLCLQREEDLQRTRDYHDCMNVVEVF---LEKFTTEWDNLARSDAESTAVHLEALKKL 4281
Query: 5023 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRW---EKV 5079
++E K ++ + ++IE D L+K ++ RW E +
Sbjct: 4282 ALALQERKYAIEDLKDQKQKMIE----------HLNLDDKELVKEQTSHLEQRWFQLEDL 4331
Query: 5080 VQRSIERG-RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH 5138
++R I+ +L++ +F E L++W E+ + ++ L+ S PD + L H
Sbjct: 4332 IKRKIQVSVTNLEELNVVQSRFQE----LMEWAEEQQPNIAEALKQSPPPDMAQNLLMDH 4387
Query: 5139 KEFQKTLGGKQPVYDTTIR-TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ 5197
L KQ + + I+ R + + L + Q + L + + + + +R+
Sbjct: 4388 LAICSELEAKQMLLKSLIKDADRVMADLGL--NERQVIQKALSDAQSHVNCLSDLVGQRR 4445
Query: 5198 HKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGK 5257
L +AL QF+ A+ + + E ++ + + D V + K Q L
Sbjct: 4446 KYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKT 4505
Query: 5258 RTGTVQVLKRSGRELI-ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAE 5316
V L GREL+ E + + + V G+LQEL + +D+V + + LE+ L +
Sbjct: 4506 YQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRK 4565
Query: 5317 VFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAM 5376
F++ WL +A+ L +++ L + + ++ +++ E + +
Sbjct: 4566 HFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRT 4625
Query: 5377 GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLA 5436
G+ IL + + + + + +F ++ AK +++ A+ A L+E
Sbjct: 4626 GQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQ 4685
Query: 5437 WIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPT 5496
+ E ++ + P ++ +L + ++E+ VD + + K++ T
Sbjct: 4686 SLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQ--KKEGFRST 4743
Query: 5497 HAPF 5500
P+
Sbjct: 4744 GQPW 4747
Score = 297 bits (760), Expect = 2e-79
Identities = 721/3932 (18%), Positives = 1520/3932 (38%), Gaps = 444/3932 (11%)
Query: 1814 LSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQP 1873
L LR ++ L+LNL ++Q+ + + ++ + E V L +N + +
Sbjct: 4897 LDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE-------VQSSLRIMNALSHKEK 4949
Query: 1874 QEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD 1933
++ KA E + +L+ SL+ +S+ Q A+ + + ++Q + Q
Sbjct: 4950 EK----FTKAKELISADLEHSLAELSELDGD----IQEALRTRQATLTEIYSQCQRYYQV 5001
Query: 1934 LRA---WVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFF 1990
+A W+ + +L G+ +DV+S L+ + + + + L+ ++
Sbjct: 5002 FQAANDWLEDAQELLQLAGNG--LDVESAEENLKSHMEFFSTEDQFHSNLE----ELHSL 5055
Query: 1991 ISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG-----HLQQMEQEALVK 2045
++ + P + + + L+ Q + + AQVD LQ H Q +E +++
Sbjct: 5056 VATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIE 5115
Query: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTT-----QQDLSALQKNQSDLKDLQDD 2100
+ + + S +AE L+ H+ + + + AL++ S L+ +D
Sbjct: 5116 LMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5175
Query: 2101 ------------IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEAL 2148
+ R T V +D E +E+ + E T K+ +A E + L
Sbjct: 5176 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILED-----AVDEWTGFNNKVKKATEMIDQL 5230
Query: 2149 QEET--RVAQKELEEAVTSALQQ------ETEKSKAAKELAENKKKIDALLDWVTSVGSS 2200
Q++ A+K + + + L+ E E+ ++A + ++ + L D
Sbjct: 5231 QDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR-QQTLSMLQDGAAPTPGE 5289
Query: 2201 GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEK--LDKQCEMMKARHQELLSQQ 2258
L+ + M+ EK T+G + + ++ ++ Q +K QE
Sbjct: 5290 EPPLMQEITAMQDRCLNMQEKVK---TNGKLVKQELKDREMVETQINSVKCWVQETKEYL 5346
Query: 2259 QNFILAT----QSAQAFLDQ---HGHNLTPEEQQMLQQKLGE---LKEQYSTSLAQSEAE 2308
N + + Q L + H N+ ++ ++ LG L + S LA+ +
Sbjct: 5347 GNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALD 5406
Query: 2309 LKQVQTLQDELQKFLQDH---KEFESWLERSEKELEN-MHKGGSSPETLPSLLKRQGSFS 2364
LK +QD++++ Q +E +++ K+L + K + + + Q
Sbjct: 5407 LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLG 5466
Query: 2365 EDVISHKGDLRFVTISGQKVLDMENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKC 2422
E++ L + + QK L+ + K+ ++ L + ++ A R + L+
Sbjct: 5467 EELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAA 5526
Query: 2423 TRLGSH---LNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL-AT 2478
+ L + L ++L + + A AW A + + +L T+ + + +L A
Sbjct: 5527 SHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAM 5586
Query: 2479 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER 2538
T++LQ + V +K+++ + E+ R +E I Q+L
Sbjct: 5587 TEKLQ-----YLTSVYCTEKMSQQVAELG-------RETEELRQMIKIRLQNL------- 5627
Query: 2539 SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIA 2598
Q A + + L+ L ++ + + L +V LS ++E L+ L ++
Sbjct: 5628 ----QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---LKEQLSHRQHLLSEME 5680
Query: 2599 RQKSSLEATREMVTRFMETADSTTAAVLQG---KLAEVSQRFEQLCLQQQEKESSLKKLL 2655
K ++A + + D + L +L E + R + +QQ + ++ +
Sbjct: 5681 SLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC---NIMQAAV 5737
Query: 2656 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI---QELNLEMEDQQENLDT 2712
Q E +E LQQ +E R + +I QI +EL +++ QE + +
Sbjct: 5738 VQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIAS 5797
Query: 2713 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR 2772
L S C ++ ++ + TV E E A ++ E
Sbjct: 5798 LN------SKC-----------KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPS 5840
Query: 2773 TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLI 2832
+ T G T +S E E S + + + N + +++
Sbjct: 5841 AHPSVVMMTAGRC---HTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIA 5897
Query: 2833 --MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHE 2890
++A Q I PS +S ++ + D+ +E L V+ E
Sbjct: 5898 YYQALSAERLQTDAAKIHPSTSAS----QEFYEPGLEPSATAKLGDLQRSWETLKNVISE 5953
Query: 2891 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2950
+Q +L L R ++ S+ +E+ E L SP + ++Q ++A +
Sbjct: 5954 KQRTLYEALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMD 6008
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR----- 3005
E+ +I +++ +LA LV+ + +Q L ER + + +
Sbjct: 6009 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 6068
Query: 3006 ------QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQF 3057
QLEE A ++ +L WL+ + + +P + AQ Q
Sbjct: 6069 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6128
Query: 3058 MLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSS 3116
ML E E + +L+ + +L G Q+ +L+ + +EL L+ +
Sbjct: 6129 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-- 6186
Query: 3117 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL 3176
Q ++ T ++ D+ Q VQ ++ QQ + + + + +LEQ
Sbjct: 6187 ---QLNMQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ- 6239
Query: 3177 DHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ 3236
E+ E ++L ++ GE+ L ++ A G A ++ + L L
Sbjct: 6240 --ELAEQKSLLRSVASR-GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEG 6286
Query: 3237 QFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE 3296
+ D++R + + S K + LQ+ L++ +E +V+ +
Sbjct: 6287 EKSSAEDQMRMKWESLHQE------FSTKQKLLQNVLEQEQE------------QVLYSR 6328
Query: 3297 GESLLLSVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKY 3348
LL VP P ++K + + L L +EE+S ++ A RQS + QK
Sbjct: 6329 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKL 6383
Query: 3349 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 3408
V W++D + ++ + L P + E+ L + + ++++ ++ +
Sbjct: 6384 YDGVSATSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQ 6442
Query: 3409 LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEG 3468
+ + D I D + + + + + ++E Q++ FQ K + +
Sbjct: 6443 AFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLAD 6502
Query: 3469 AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQ 3528
K+ + Q +N + + Q E +Q E D L+ F G++E G
Sbjct: 6503 NKYII-------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK--- 6549
Query: 3529 LLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGA 3587
L + + QE +++ + +++ ++ G+ Q + L DL D L+ G
Sbjct: 6550 -LQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEK 6608
Query: 3588 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE- 3643
+ D + S E+++ L+K +E+ HM+ E + +++E +
Sbjct: 6609 MAGDQKIIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQF 6662
Query: 3644 --ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3701
L Q + +R R +LE L E + + + + E E+ VG
Sbjct: 6663 HTELMAQASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVE 6719
Query: 3702 EIINQQLADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINAR 3759
E ++ + ++Q K ++ Q KL QV G+ L+ S LE + ++
Sbjct: 6720 ENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGEC 6775
Query: 3760 WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVV 3815
W + K+++ + +L+ L H ++Q L+ WL ++ + S E ++V
Sbjct: 6776 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMV 6835
Query: 3816 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3875
+ + + +D + + + + G ++ + ++ D + +L ++S+WT+LL+
Sbjct: 6836 RDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTN 6894
Query: 3876 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIR 3930
A Q++L + + + ++S+ E + E +G + I + + +
Sbjct: 6895 IPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQK 6952
Query: 3931 HKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDR 3984
+K + DI V + QS+ ++S + S+K D ++ + +Q
Sbjct: 6953 YKGFKIDINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGL 7009
Query: 3985 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN 4044
K LL+ L + + E+ V+ L E ++K + Q + D L
Sbjct: 7010 VTEKIQLLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 7068
Query: 4045 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 4104
+ I ++K V++ +NG AL++ + ++ L + +A++ + L+
Sbjct: 7069 DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV 7128
Query: 4105 RQLATKFQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHR 4160
+ + ++++ +L E L+ +G Q+ Q Q +L+K+
Sbjct: 7129 LDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS-- 7186
Query: 4161 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 4220
L ++ LL+ E L + + N ++ + + I +++ A +Q Q+Y
Sbjct: 7187 --LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY 7244
Query: 4221 E----QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELF 4276
+ Q A T L A + D+ +Q + KDS+ L
Sbjct: 7245 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 7304
Query: 4277 SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 4336
++ + +Q SL Q A+ ++ L+ + F ++ E L
Sbjct: 7305 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 7364
Query: 4337 SPWIEETRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 4395
WI E ++ Q PS + D ++++ EE++ + P +D+L ++G +L LN
Sbjct: 7365 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LN 7423
Query: 4396 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 4455
+E ++ Q ++ I + +R L + Q F +K E +E L
Sbjct: 7424 DKE----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTE 7476
Query: 4456 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA 4515
+L + I + E ++ E+ Q ++ G+ L+ + Q D+D
Sbjct: 7477 QKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD--- 7531
Query: 4516 KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLE 4575
E KL + W+ + RA++R +++ + W + ++ V L
Sbjct: 7532 -EFNLKLTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7586
Query: 4576 SPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA---------DLIFACGETEKPE 4626
G+ I Q A T+ +E +E F+R G+ L+ + +
Sbjct: 7587 MSGLGSVPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7642
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
++ + E+ W++ + +E+ +KL ++ ++ + + D L+
Sbjct: 7643 LQAELAEIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADSLEK----------- 7688
Query: 4687 GTDLNTVKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DET 4732
L T K +L++ + + E++ +Q+ ++L + +L L K T
Sbjct: 7689 ---LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISAD 7745
Query: 4733 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4792
D I+ E + L+ WE L +++ R+ ++ L F +EL WLT E +
Sbjct: 7746 DISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ 7805
Query: 4793 QRPISGDPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4851
+GD + E +E K + +A + ++ + + G L ++S AS + +L
Sbjct: 7806 ----NGDILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLG 7860
Query: 4852 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGL 4908
+N W+ +L R ++L+ TL Q + L +ES+L+ KP
Sbjct: 7861 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCN 7918
Query: 4909 PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQ 4965
E + +L+ EL ++ +L+ ++L D + ++ + Q+ L++
Sbjct: 7919 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7978
Query: 4966 KWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ 5025
+W + + ER+ K+EE L +F + F +WL +E++ S +I +
Sbjct: 7979 RWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEE 8038
Query: 5026 IEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE 5085
+++ + F +V+ Q+ +++ +L ++ +K ++ RW+ + +R
Sbjct: 8039 LKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8098
Query: 5086 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTL 5145
R L + ++F A ++ WL + + L + +E ++ D ++ ++ + K FQ+ +
Sbjct: 8099 ILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEI 8156
Query: 5146 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
+ I G L EK+ P D+ ++ L E+R V G+ VER HK L
Sbjct: 8157 SLNHNKIEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHKKLIRLP 8214
Query: 5206 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL 5265
D ++ ED DL D+ Q Q L
Sbjct: 8215 LPDDEHDLSDRELE---------LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8265
Query: 5266 K--RSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 5323
+ RSGR+ + + WD LS +S + +AL +
Sbjct: 8266 RSERSGRD-----------TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE------ 8308
Query: 5324 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL-- 5381
E + + LR L D AL+S I ++ K +++ R + E I+
Sbjct: 8309 ---EGQDDKDFYLRGAVGLSGDHSALESQI---RQLGKALDDSRFQIQQT----ENIIRS 8358
Query: 5382 -AVCHPDCITTIKHWITIIR---------ARFEEVLTWAKQHQQRL---------ETALS 5422
P+ T+ K ++ ++ R E L K+ ++ L ET +
Sbjct: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTA 8415
Query: 5423 ELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVD 5482
++ ELL+ + +Q+ Q+ +++ + A + + + +E++ R + D
Sbjct: 8416 GVIDRWELLQAQALSKELRMKQNLQKWQQ-FNSDLNSIWAWLGDTEEELEQLQRLELSTD 8474
Query: 5483 RVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK-----NPRINQLS 5537
T + K ++ + RK++ P +Q+++K R++Q++
Sbjct: 8475 IQTIELQIKKLKEL------QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMN 8528
Query: 5538 ARWQQVWLLALERQRKLNDALDRLEELKEFAN 5569
RW +V L E + L DAL + + E ++
Sbjct: 8529 GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSH 8560
Score = 280 bits (716), Expect = 3e-74
Identities = 637/3657 (17%), Positives = 1404/3657 (38%), Gaps = 434/3657 (11%)
Query: 1953 EIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNE 2012
E+ ++ L +Q ED++Q + AQ + E Q+ + ++M +++
Sbjct: 736 EVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE----EGKEMFATMSK 791
Query: 2013 LQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAER-A 2071
L+ + E + + Q L +E+ L+KQ + + L + + ER A
Sbjct: 792 LKEQLTKVKECYSPLLYESQQLLIPLEE------LEKQMTSFYDSLGKINEIITVLEREA 845
Query: 2072 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 2131
+ + Q+L A Q+N L + F T+ ++ F +
Sbjct: 846 QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHF-----------DQ 894
Query: 2132 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA--------AKELAEN 2183
T L+ ++ ++++ ++T +K +E S L ++ E+S+A A+E E
Sbjct: 895 TRLQRQIADIHVAFQSMVKKTGDWKKHVE--TNSRLMKKFEESRAELEKVLRIAQEGLEE 952
Query: 2184 KKKIDALLDWVTSVGSSGGQLLTN--LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 2241
K + LL T S Q + N L ++L+ E+ G+ +A KL
Sbjct: 953 KGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQ-------QGLQEAVRKLH 1005
Query: 2242 KQ------------------------------CEMMKARHQELLSQQQNFILATQSAQAF 2271
KQ C R +L+ Q+ + + + F
Sbjct: 1006 KQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFF 1065
Query: 2272 LDQHGHNLTPEEQQMLQQKLGEL--KEQYSTSLAQSEAELKQVQTLQDEL-QKFLQD--- 2325
D+ H+L + Q++++ +L ++ + LK+++ D +K ++D
Sbjct: 1066 SDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK 1125
Query: 2326 -------HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVT 2378
EF SW+ +E +L+ + KG + +KR + ++ +G+
Sbjct: 1126 WKDYTSRFSEFSSWISTNETQLKGI-KGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL 1184
Query: 2379 ISGQKVLDMENSFKEG-KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYH 2437
S KVL +S E K+ E+ KL + + L S+ ++ S+ +
Sbjct: 1185 KSRLKVLTEVSSENEAQKQGDELA-----KLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1239
Query: 2438 QFQNSADSLQAWMQACEANVEKLL-SDTVASDPGVLQEQLATTKQL-------QEELAEH 2489
+NS + L + + + EK+L ++ + +L TK++ Q+++A+
Sbjct: 1240 IVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQA 1299
Query: 2490 Q-----VP---VEKLQKVARDIMEIEGEPAPDHRHVQ---------ETTDSIL------- 2525
Q +P E+L+K+ + +E R +Q ET +
Sbjct: 1300 QQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQT 1359
Query: 2526 --SHFQSLSY-SLAERSSLLQKA---IAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLS 2579
SH + LS+ SL SS L++ +++S+ E+L++ E+ + KQ+
Sbjct: 1360 GSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQ 1419
Query: 2580 SGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV---------LQGKL 2630
+ I+E + KL+ + ++E + F ++ + + L+
Sbjct: 1420 AKSIKEQV---KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSS 1476
Query: 2631 AEVSQRFEQLCLQQQEKESSLKKLL---PQAEMF---------EHLSGKLQQFMENKSRM 2678
+ + + Q+ + QE ES L ++ +A+ F + KL Q +
Sbjct: 1477 SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEEL 1536
Query: 2679 LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLE-HLVTELSSCGFA----------L 2727
+ I Q Q+ + Q+++ E L + C A +
Sbjct: 1537 REHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHM 1596
Query: 2728 DLCQHQDRVQNLRKDFTELQKTVKERE---KDASSCQEQLDEFRKLVRTFQKWLKETEGS 2784
DLCQ + + + F+ + V R+ ++A++ Q+Q ++ + + Q L+
Sbjct: 1597 DLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALE----- 1651
Query: 2785 IPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVE-EINCKGTSLENLIMEITAPD---- 2839
+ LEK++ + L+ +K + E +I+ +E + I A
Sbjct: 1652 ----NLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1707
Query: 2840 SQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAIL 2899
SQ S L + S+ SV + D+ ++ + ++ ++ L ++++R LQ+++
Sbjct: 1708 SQASFYSKLLQLKESLFSV---ASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVV 1764
Query: 2900 NRMEEVHKEANSVLQWLE------SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2953
++ + S W++ + MD + T+ + A+ ES K L L+
Sbjct: 1765 AEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQ 1824
Query: 2954 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 3013
+ K+ + A ++ + E+ +E A++V RQ L SH
Sbjct: 1825 GHLAKLGSLGRA-----------EDLHLLQGKAEDCFQLFEEASQVVERRQLAL----SH 1869
Query: 3014 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNA-QKQQVQFMLKEFEARRQQHEQL 3072
LA F + + L G+L L N+ K + + K+ Q + L
Sbjct: 1870 LAEFLQSHASL----------SGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKAL 1919
Query: 3073 NEAAQGILTGPGDVSLSTSQVQKELQSINQKW-------------VELTDKLNSRSSQID 3119
AA + D LS +Q ++ S Q+ + + L ++ S+ D
Sbjct: 1920 ESAAVSL-----DGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD 1974
Query: 3120 QAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHE 3179
V +Q+ ++L + + + +R + +A++Q+L +++ +L +HE
Sbjct: 1975 ALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHE 2034
Query: 3180 VKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQ 3239
+ + +++ + E+ + + + + + L + + + +++Q
Sbjct: 2035 LCWLKDKAKQIAQ--KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQ 2092
Query: 3240 QMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGES 3299
+ + L++ S I + E L+ ++E + +N + ++G+
Sbjct: 2093 NLKSAVSKVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKH 2151
Query: 3300 LL--LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVP 3357
LL L + ++ + + W ++S+K + RL+ + +++
Sbjct: 2152 LLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEG 2211
Query: 3358 WIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL--INSSEA 3415
W +C +M+E LD LL K +EV+ + LE L+S + L + +
Sbjct: 2212 WSNNCVPQMAENISNLDNHLRAEELL--KEFESEVKNKALRLEELHSKVNDLKELTKNLE 2269
Query: 3416 DEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI 3475
++ +A + Q ++ E + G+L++ T + + ++ +I + L
Sbjct: 2270 TPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-- 2327
Query: 3476 FDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEV 3535
N+ E L+ +++ + L+ Q + + + L + + H AE+
Sbjct: 2328 -----MNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL-------NSLCRKYHSAEL 2375
Query: 3536 -----AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGR 3590
A ++ + V+ C + L+ + H Q L + + R
Sbjct: 2376 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDR 2435
Query: 3591 DTDS--LQSQIEDVRLFLNKIH--VLKLDIEASE-----AECRHMLEEEGTLDLLGLKRE 3641
DS L++++ D++ L+ + KLD E A + + E
Sbjct: 2436 TGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEE 2495
Query: 3642 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLK----GLNDATTAAEEAEALQWV- 3696
+A KQC K K + LG ED +RKL + + E+ Q +
Sbjct: 2496 FQAFLKQCLK----DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIP 2551
Query: 3697 -VGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3755
EV + L + + +E +D L + Q ++ G G Q G+ C H
Sbjct: 2552 EKKNEVHKVEMFLGEL-LAARESLDKLSQRGQLLSEEGHGAGQE-GRLCSQLLTSH---- 2605
Query: 3756 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3815
L + +++ Q AL ++AL+ + W+ ++ +A + +
Sbjct: 2606 -----QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTL 2660
Query: 3816 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3875
+ ++ + + + + + + ++M +G + +S+ + I QLE+L+ W +++S
Sbjct: 2661 EKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSS 2720
Query: 3876 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQII--RHKA 3933
+ Q LE ++ + E + ++ ++K+ P+ Q ++ ++ ++
Sbjct: 2721 SVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI--EHPLQPQPGLKEKFVLLDHLQS 2778
Query: 3934 LEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLD 3993
+ + E+H +H+ + + L T ++ + L+ ++++I K ++
Sbjct: 2779 ILSEAEDHTRALHRLIAKSRELYEKTE--DESFKDTAQEELKTQFNDIMTVAKEKMRKVE 2836
Query: 3994 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 4053
+ + + ++ + E +WL +++L D D Q L+ +E+++ ++
Sbjct: 2837 EIVKDHLMYLDAVHEFTDWLHSAKEELHR--WSDMSGDSSATQ--KKLSKIKELIDSREI 2892
Query: 4054 VDQAIKNGQALL----KQTTGEEVLLIQEKLDGIK------------TRYADITVTSSKA 4097
+ ++L + TT L+ ++ ++ T+ + S A
Sbjct: 2893 GASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA 2952
Query: 4098 LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE----LK 4153
L E + Q+A + + E+ + L+ ++L G++ T E+I + + +E L+
Sbjct: 2953 LSEQEFSGQVA-QLEQALEQFSALLKTWAQQLTLLEGKN-TDEEIVECWHKGQEILDALQ 3010
Query: 4154 KEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAA 4213
K + +NE+ R +L + + VS ++Y + + +
Sbjct: 3011 KAEPRTEDLKSQLNELCRFSRDLSTYSGK------VSGLIKEYNCLCLQASKGCQNKEQI 3064
Query: 4214 IQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMD 4273
+Q Q++ +A W+ K I + + LQ + F + + ++
Sbjct: 3065 LQ--QRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLN 3122
Query: 4274 ELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
+ S + +E+ +Q K + + ++ ++ + LE ++ + F +
Sbjct: 3123 MMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSA 3182
Query: 4334 EELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE 4393
E + W+ +T ++ + + D R++Q++++ + E I ++P +++L + QL E
Sbjct: 3183 EPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE 3242
Query: 4394 LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ----ITEFHDKIEPMLE 4449
+ + + + Y + +++ LD V++ Q I E D + +
Sbjct: 3243 -GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3301
Query: 4450 TLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4509
L++ ++ + K+ +S + +++ + + RGE ++ +
Sbjct: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQM-------KMIVTRGESVLQNTSPE 3354
Query: 4510 DKDLAAKEIQDKLDQMVFFWEDI-------KARAEEREIKFLDVLELAEKFWYDMAALLT 4562
IQ +L + W + K++ E K+ + +F M ++
Sbjct: 3355 ----GIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEA 3410
Query: 4563 TIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGET 4622
+ +++ +L + A+ + EE LE I + GA G T
Sbjct: 3411 NLNESERQHAELRDK-------TTMLGKAKLLNEEVLSYSSLLETIEVKGA------GMT 3457
Query: 4623 EKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT 4682
E + + ++ + + + KE + K E ++ +YQ L+A WL KL
Sbjct: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ 3517
Query: 4683 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLT 4742
+ D +T + L +++E +V + Q + + H E ++ + + L
Sbjct: 3518 YSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE----DRALE 3573
Query: 4743 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV 4802
L+ W+ +++ + + + L + +++ WL EE + + +
Sbjct: 3574 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRAT 3633
Query: 4803 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESS-----AGDDASSLRSRLEAM---- 4853
E++L + +V A++ VE V E+L+ S G A+ L SR +A+
Sbjct: 3634 KEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQV 3693
Query: 4854 ---NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPE 4910
+ E +Q EE E L S H ++ ++ ++++ + K E
Sbjct: 3694 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLK--TLE 3751
Query: 4911 TAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVV 4970
+ ++ L + K E + L++G L ++ +EQ +
Sbjct: 3752 VLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDH----------MEQLKELT 3801
Query: 4971 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 5030
S+ +E + LE+ L+LA EF + + W+ ++ L++ P + L +Q+ ++K
Sbjct: 3802 STVRKEHMT-LEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYK 3860
Query: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
V +H + + + G L L QDV L K+ + +QS ++ + E SL
Sbjct: 3861 SLQQTVLSHEPSVKSVREKGEAL--LELVQDVTL-KDKIDQLQSDYQDLCSIGKEHVFSL 3917
Query: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDS-ELEISNDPDKIKLQLSKHKEFQKTLGGKQ 5149
+ K + ++ +++ WL L + +L ++ + I QL+ HK + + G +
Sbjct: 3918 EAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFE 3977
Query: 5150 PVYDTTIRTGRALKEKT---LLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 5206
+ G L + L + Q + L +D + +C + LE L
Sbjct: 3978 DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 4037
Query: 5207 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK 5266
D LQ WL V+P L E P Q L + QV
Sbjct: 4038 HVSRQDTLQQCQAWLSAVQPDL-EPSP------------------QPPLSRAEAIKQV-- 4076
Query: 5267 RSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQA----EVFRDTV 5322
+ R L E +R + + T K + +EQ L QA + + +
Sbjct: 4077 KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIK 4136
Query: 5323 HMLLE---WLSEAEQTLRFRGALPDDTE--ALQSLIDTHKEFMKKVEEKRVDVNSAV 5374
H+ E +L +A+Q L+ + E Q+++ K+F+KK++ K+ VN+ +
Sbjct: 4137 HLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
Score = 267 bits (683), Expect = 2e-70
Identities = 716/3774 (18%), Positives = 1476/3774 (39%), Gaps = 481/3774 (12%)
Query: 1883 ALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD--------L 1934
ALE+ A L+K+ + S SR + T V + T+L QD +
Sbjct: 5161 ALEEKASQLEKTGNDASKATLSRSM----------TTVWQRWTRLRAVAQDQEKILEDAV 5210
Query: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER--KAQLDALAFDIQFFIS 1992
W G N + K + ID Q + L AE+ KA+L L F+
Sbjct: 5211 DEWTGFNNKV---KKATEMID--------QLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5259
Query: 1993 EHAQDLSP--QQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA-----LVK 2045
E Q S +Q L +L + ++ A+Q M+++ LVK
Sbjct: 5260 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5319
Query: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGH------QGRTTQQDLSALQKNQSDLKDLQD 2099
K + Q+ + WV + + L Q Q L+ ++ +++ + +
Sbjct: 5320 QELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE 5379
Query: 2100 DIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKEL 2159
+ + + T++ E ++ + L + +++K+ + ++ QE +R QK
Sbjct: 5380 EQKEKYLGLYTILPS-ELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLA 5438
Query: 2160 EEAVT----------SALQQETEKSKAAKELAENKKKI----DALLDWVTSVGSSGGQLL 2205
++ T + +Q +T++ +EL K+ A+ ++ G G L
Sbjct: 5439 KDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLA 5498
Query: 2206 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA--RHQELLSQQQNFIL 2263
+ + +L ++ + + +NQA L++ EM++ + E + +
Sbjct: 5499 KKIGKLTELHQQTIRQAE----NRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTI 5554
Query: 2264 ATQSAQAFLDQHG-HNLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE-- 2318
A SA +Q+ H EE + + +L + E QY TS+ +E +QV L E
Sbjct: 5555 AWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETE 5614
Query: 2319 ------------LQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 2366
LQ +D K+FE+ L++ + LE +SPE LK Q S +
Sbjct: 5615 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 5674
Query: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
++S L+ Q V +++ + ++ L L+ E H+ +
Sbjct: 5675 LLSEMESLKPKV---QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCN 5731
Query: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
+ + QY Q++ LQ ++ +E S+ LQ Q++ ++L +++
Sbjct: 5732 I-MQAAVVQYEQYEQEMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKI 5788
Query: 2487 AEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI 2546
+Q + L + ++ ++ + A V E + + + L L S +
Sbjct: 5789 KGYQEQIASLNSKCK-MLTMKAKHATMLLTVTEV-EGLAEGTEDLDGELLPTPSAHPSVV 5846
Query: 2547 AQSQSVQESLES-LLQSIGEVEQNLE---------GKQVSSLSSGVIQE-----ALATNM 2591
+ +L S + + GE N E V++ + V Q+ AL+
Sbjct: 5847 MMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAE- 5905
Query: 2592 KLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSL 2651
+L+ D A+ S A++E +E S TA KL ++ + +E L EK+ +L
Sbjct: 5906 RLQTDAAKIHPSTSASQEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTL 5958
Query: 2652 KKLLPQAEMFEH----LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ 2707
+ L + + ++ +S K++ S G P+ + + E+ + ++
Sbjct: 5959 YEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEIN 6018
Query: 2708 ENLDTL-EHLVTELSSCGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSC 2760
E +L E LV+E A L +R+ +R + ++ ++E+ D
Sbjct: 6019 ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEE 6078
Query: 2761 QEQ---LDEFRKLVRTFQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWA 2812
Q Q L +R WL T+ ++ PP E ++E Q+ +++L +
Sbjct: 6079 QRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIE 6134
Query: 2813 SKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQC 2872
K + E++ ENL++E GK HT + ++
Sbjct: 6135 QKVVALSELSVHN---ENLLLE-------GKA-----------------HTKDEAEQLAG 6167
Query: 2873 DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP 2932
+ + +L LH++Q ++Q + KEE + A SP
Sbjct: 6168 KLRRLKGSLLELQRALHDKQLNMQGTA-----------------QEKEESDVDLTATQSP 6210
Query: 2933 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSR 2992
E + AQA + +Q +Q+ KE QE K + + SR
Sbjct: 6211 GVQEWL-AQARTTWT-----QQRQSSLQQQKEL----------EQELAEQKSLLRSVASR 6254
Query: 2993 WERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQK 3052
E E H A + ++ +P ++ +EL M + D + +
Sbjct: 6255 GE-------------EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWES 6301
Query: 3053 QQVQFMLKEF---EARRQQHEQL-----NEAAQGILTGPGDV-SLSTSQVQKELQSINQK 3103
+F K+ Q+ EQ+ N G+ GDV + S V L +NQ
Sbjct: 6302 LHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQA 6361
Query: 3104 WVELTDKLNSRSSQIDQAIVKSTQYQELLQD----LSEKVRAVGQRLSVQSAISTQPEAV 3159
+ E+ SSQ A +S ++ L D S + V +RL V +A+ PE
Sbjct: 6362 FEEV-------SSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL--PEET 6412
Query: 3160 KQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLED 3219
+ L + D++++ E+ + + L + G+ +D ++ L + L L+
Sbjct: 6413 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDN--RDVIEDTLGCLLGRLSLLDS 6470
Query: 3220 LAADRINRLQAALASTQQFQQMFDELRTWLDDKQS---QQAKNC---PISAKLERLQSQL 3273
+ R ++++ L FQ L T L D + Q+ N P++ ++E +Q
Sbjct: 6471 VVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAE 6530
Query: 3274 QENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTAD 3333
+EF + + + G+ L + P +E L +L++ ++EL
Sbjct: 6531 DGLKEFDAGIIE-------LKRRGDKLQVEQPSMQE-------LSKLQDMYDELMMIIGS 6576
Query: 3334 RQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMS--ELRVTLDPVQLESSLLRSKAMLNE 3391
R+S L + +Y+ ++DL +E + KM+ + + +++ L + K
Sbjct: 6577 RRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQG 6636
Query: 3392 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQR 3451
+E L E L +I+ + E E + AV + + LE +
Sbjct: 6637 LESHMILTETLFRK---IISFAVQKETQFHTE---LMAQASAVLKRAHKRGVELEYIL-- 6688
Query: 3452 LREFQESFKNIEKKVEGAKHQLEIFDA-LGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3510
E++ ++++ + QLE+ ++ + S +N ++L + + Q L+ L
Sbjct: 6689 -----ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS---LN 6740
Query: 3511 NFTQGLVEDAPDGS------DASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564
+ L + DG S L Q + +L +++ +E L+ ++
Sbjct: 6741 EYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRY 6800
Query: 3565 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3624
++ L D L+ + + ++ ++E VR LN +++A +
Sbjct: 6801 QSESADLIHWLQSAKDRLEFWT---QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKS 6857
Query: 3625 HMLEEEGTL------DLLGLKRELEALNKQCGKLTERGKARQEQL-ELTLGRVEDFYRKL 3677
+L L D L+ EL ++ Q L A QE+L +L + ++ +
Sbjct: 6858 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6917
Query: 3678 KGLNDATTAAEEAEALQWVVGTEV--EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3735
+ ++ + + + + + + I++ L +K F+ + + K V+ + Q
Sbjct: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQS 6973
Query: 3736 LIQSAGKDC-----DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEP 3790
++Q + +D D + +N W L V ++I L+ L ++++ ++
Sbjct: 6974 VLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 7033
Query: 3791 LLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSA 3850
L +W +T+E Q+ + V+ +++ + L+ L+ ++ V+ ++ G + Q+
Sbjct: 7034 LKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK 7092
Query: 3851 ELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKK 3910
+ + L L W L + L+ +L + I+ +L
Sbjct: 7093 KEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYS 7152
Query: 3911 LANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEK 3970
L+ + +Q Q+ + L++D+E + + I L P L+
Sbjct: 7153 LSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNT 7212
Query: 3971 IDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 4030
+ + R++ + + + L + + + + + + + ED+ + + +
Sbjct: 7213 LKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNK 7272
Query: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAI----KNGQALLKQTTGEEVLLIQEKLDGIKTR 4086
D+ + A + +++ V ++ + G+ L +Q IQ +
Sbjct: 7273 DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 7332
Query: 4087 YADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPT-GEQIPQF 4145
+ K +L+ F + E L W+ E EE L GQ P+ +
Sbjct: 7333 LCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ---GQDPSHSSDLSTI 7389
Query: 4146 QQRQKELKKEVMEHRLV---LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDT 4202
Q+R +ELK ++++ + LD +NE+ L P +E K + + N + L+S
Sbjct: 7390 QERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNLNRHWSLISSQ 7443
Query: 4203 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 4262
+R ++ + + + Q + + + + ++ +T++KL + + + L+ Q+A
Sbjct: 7444 TTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLA----VEISGNYQHL-LEQQRA-- 7496
Query: 4263 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 4322
H+ E+FS + + + Q+ + Q + + + ++LL+++ + RA
Sbjct: 7497 -----HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7551
Query: 4323 Q----VLVNQF--WETY----EELSPWIEETRAL-IAQLPSPAIDHEQLRQQQEEMRQLR 4371
Q ++ +Q W+ Y E+L W+ E L ++ L S I +Q R +E++
Sbjct: 7552 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE 7611
Query: 4372 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAV 4431
+ + ++ G QL L+ + G E +AE A+I+E+ + ++ L+E
Sbjct: 7612 KVFLRQQGSYILTVEAGKQLL-LSADSGA---EAALQAE--LAEIQEKWKSASMRLEEQK 7665
Query: 4432 SQSTQITEFHDKIEP-MLETLENLSS-RLRMPPLIP-------AEVDKIREC-------- 4474
+ + + +K E + ++LE L + + ++ +P AE + +E
Sbjct: 7666 KKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWT 7725
Query: 4475 --------ISDNKSATV---ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLD 4523
+ D SA + ++ L E L+R+ EEL + L ++I ++L+
Sbjct: 7726 DDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS-----LRRQQIGERLN 7780
Query: 4524 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4583
+ F E K EL E W + + + + DI +
Sbjct: 7781 EWAVFSEKNK--------------ELCE--W--LTQMESKVSQNGDI------------L 7810
Query: 4584 IKQQVEAAETIKEETDGLHEELEF-IRILGADLIFACGETEKPEVRKSIDEMNNAWENLN 4642
I++ +E + +E + +E + ++ +G L A E++ E+ + ++N+ W++L
Sbjct: 7811 IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLL 7870
Query: 4643 KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT--VKDQLNEM 4700
R++KL++ + A Q + ++ WL + +L P V N+ ++ +LNE
Sbjct: 7871 DLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK-PIVYDSCNSEEIQRKLNEQ 7929
Query: 4701 KEFKVEVYQQQIEMEKLNHQGELMLKK----ATDETDRDIIREPLTELKHLWENLGEKIA 4756
+E + ++ + + + + E++L ATD + D I++ L W N+
Sbjct: 7930 QELQRDIEKHSTGVASVLNLCEVLLHDCDACATD-AECDSIQQATRNLDRRWRNICAMSM 7988
Query: 4757 HRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKND 4816
R+ K+E +F WL +E V + EL K +
Sbjct: 7989 ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQ 8048
Query: 4817 VLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQ 4876
V +E +NK L + D A SL+ + NQ W+++ ++ ++L+ +
Sbjct: 8049 VHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIG 8108
Query: 4877 QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR-EQLDTHMELYSQLKAKEETYNQ 4935
Q + F + + L+ LT M+ QL+ + A+ +QL + ++ Q
Sbjct: 8109 QREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ---EISLNHNKIEQ 8165
Query: 4936 LLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKL--------EEALN- 4986
++ +G L+ + + + E+ + L + V ++E KL E L+
Sbjct: 8166 IIAQGE-QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 8224
Query: 4987 --LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044
L E +L + ++W + SL ++ PS L+ L+Q + + A D I
Sbjct: 8225 RELELEDSAALSD-LHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIP 8282
Query: 5045 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA----KQF 5100
L D L ++L +S + + E G+ D R
Sbjct: 8283 -----------LEWDHDYDLSRDL----ESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD 8327
Query: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQL-------SKHKEFQKTLGGKQPVYD 5153
H A + I L A DS +I + I+ + + +K + K LG D
Sbjct: 8328 HSALESQIRQLGKALD--DSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8385
Query: 5154 TTIRTGRALKEKT-LLPE--DSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQF 5210
+ R LKE+ LP + + V D+W+ + +++ ++ ++++ L QF
Sbjct: 8386 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQF 8445
Query: 5211 MDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV--FQKELGKRTGTVQVLKRS 5268
L ++ WL E +L + Q + D+ + K+ QK + R + +
Sbjct: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
Query: 5269 GRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 5328
E + ++ ++ +L +++ RWD VC L + L+ AL Q + F + H LL
Sbjct: 8506 SPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLM 8565
Query: 5329 LSEAEQTLRFRGALPDDTEA-LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAV 5383
L ++ R +P D+ + L D HK+ M+ ++ E ++ V S M ++++
Sbjct: 8566 LENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA 8623
Query: 5384 CHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAW 5437
DC+ K + +I R + +L +H + LE L V++++ ++L +W
Sbjct: 8624 EGTDCLEA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 8672
Score = 264 bits (674), Expect = 2e-69
Identities = 655/3421 (19%), Positives = 1371/3421 (40%), Gaps = 381/3421 (11%)
Query: 1805 EHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAK----VLERELKDLTTLVSQ 1860
E ++ + L R I+ K + + L D + QAK VL EL + +
Sbjct: 5419 EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKL-M 5477
Query: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWN------SRLLHFQNAVE 1914
EL+ Q + Q ++ L K + K + Q+++ + + S L + +E
Sbjct: 5478 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 5537
Query: 1915 -----IEKTKVLNQHTQLEGRLQDLRA-WVGNKNLILNSKGSNSEIDVDSLNLCLQQYED 1968
IEK KVL T LR ++ ++ L+ SK +SE++ + L
Sbjct: 5538 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 5597
Query: 1969 LKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQV 2028
+ M+++ A+L +++ I Q+L + M + EL++ Q LEQ A +
Sbjct: 5598 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA-KDMKKFEAELKK-LQAALEQAQATL 5655
Query: 2029 DALQ-GHLQQMEQEALVKTLQKQQNTCHQQLE--DLC-SWVGQAERALAG----HQGRTT 2080
+ + G L EQ + + L + + +++ LC S + E +A H
Sbjct: 5656 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRL 5715
Query: 2081 QQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL-TALREKLH 2139
Q++ S LQ ++ + + +K ++ +E ++ + + T+ ++L
Sbjct: 5716 QEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQ 5775
Query: 2140 QAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA---------KELAENKKKIDAL 2190
++E L ++ + Q+++ ++ S + T K+K A + LAE + +D
Sbjct: 5776 AQISRHEELAQKIKGYQEQIA-SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGE 5834
Query: 2191 LDWVTSVGSS-----GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCE 2245
L S S G+ T L + + SG + + + D
Sbjct: 5835 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANT-DASVN 5893
Query: 2246 MMKARHQELLSQQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 2300
A +Q L +++ A T ++Q F + P + KLG+L+ + T
Sbjct: 5894 QDIAYYQALSAERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWET 5946
Query: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360
+ + + + QK+ + + +E E +L + G SPE S +
Sbjct: 5947 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEH 6003
Query: 2361 GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHS 2420
+ ++++ + ++ + S + L E+ + E + + L ER + +
Sbjct: 6004 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRM 6059
Query: 2421 KCTR----LGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPG 2470
K + L LN L + Q ++ AD L +W+ + +A ++ LS +P
Sbjct: 6060 KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPM 6117
Query: 2471 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2530
++ QL + + E+ + V + +L V + + +EG+ H ++ + + +
Sbjct: 6118 DMEAQLMDCQNMLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRR 6171
Query: 2531 LSYSLAE-RSSLLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQ 2584
L SL E + +L K + + QE ES QS G E + + + Q
Sbjct: 6172 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---Q 6228
Query: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQ 2644
+L +L+Q++A QKS L R + +R E +AA G E Q +
Sbjct: 6229 SSLQQQKELEQELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6285
Query: 2645 QEKESSLKKLLPQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPD 2686
EK S+ ++ + E + + S K LQ +E + L G+ P
Sbjct: 6286 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6345
Query: 2687 QDITHFFQQIQELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2738
QD + + LN E+ +++++ + L +S+ LD + + V
Sbjct: 6346 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6405
Query: 2739 -LRKDFTELQKTVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------ 2783
L + TE +E KD E++D+ + L + +++T G
Sbjct: 6406 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6465
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAP 2838
S+ + + +++++++ + + +D T + + + E + E
Sbjct: 6466 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEA 6525
Query: 2839 DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898
Q + G G G + +Q ++S + Y++L ++ R+ L
Sbjct: 6526 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQN 6584
Query: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958
L + + + LE+ +E + + +K E ++ + +K + LE +
Sbjct: 6585 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH--- 6640
Query: 2959 IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQ 3018
+ E L ++++ +E + ++ + ++ +RA + V + LE + SHL
Sbjct: 6641 -MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---D 6695
Query: 3019 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 3078
+ +L L E + +G + + + L + Q + + + Q+ + +
Sbjct: 6696 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6755
Query: 3079 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 3138
+L +S+S S ++ +L + + W+ T+K++ +++ + T+YQ DL
Sbjct: 6756 LL-----ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 6810
Query: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
+++ RL + Q V Q+LE + + + EV +AQ+ + G Q
Sbjct: 6811 LQSAKDRLEFWTQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQL 6866
Query: 3199 LKDELKKRLETVAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWL 3249
L+ K+++T L L ++ D + + A Q Q E+ +W+
Sbjct: 6867 LR---LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 6923
Query: 3250 DDKQSQQAK---NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVP 3305
++ K N S + + LQ+ + F+ +N + + + +S+L +S
Sbjct: 6924 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQ 6980
Query: 3306 PGEEKRT----LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
E KR+ QL + W+ L ++ L+ ++ +Y+ +V+ L W E
Sbjct: 6981 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 7040
Query: 3362 CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIR 3421
+ ++ + D ++++L + + + ++ + +E + LI + + D I
Sbjct: 7041 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI- 7099
Query: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 3481
+ + EL +L+ M +L+ +S + + + H++ FD + S
Sbjct: 7100 ---------VMSTLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINS 7144
Query: 3482 QACSNK-NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVA 3536
+ +L + R L+A++ QVD L+N L + GS +QLL +
Sbjct: 7145 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 7204
Query: 3537 QQEFL-----EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRD 3591
E L EV R N+ ++E E + Q + +++ + D +
Sbjct: 7205 VTETLTNTLKEVNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQ 7250
Query: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEAL 3645
S Q ED L K K DI E +C +L+ GT+ D L EL
Sbjct: 7251 CASTVQQQEDRTNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
Query: 3646 NKQCGKLTERGKARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVV 3697
KQ + + +QL L+ L +E K + G+ D T A+ EAL+ W+V
Sbjct: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
Query: 3698 GTEVEIINQQ----LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE- 3750
E EI+ Q +D Q E+++ L+ ++ + + + L + G + E
Sbjct: 7370 EAE-EILQGQDPSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7427
Query: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810
M+ +N W+ ++ + +R ++LQ LL F + E + +L TE+ +A + S
Sbjct: 7428 KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SG 7485
Query: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT 3870
Y+ + Q + +L Q + R+ + + +G R+ + ++ DR++ +L L ++W
Sbjct: 7486 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 7545
Query: 3871 ELLSKAAARQKQLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQ 3927
++ +A R+ ++ + +++ E AE + +L S S P+ Q A+
Sbjct: 7546 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 7605
Query: 3928 IIRHKALEEDIENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC 3986
++ K E+ V+ G Q L S S AE +LQA +EIQ++
Sbjct: 7606 EVQFK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWK 7655
Query: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046
+ L++ +D + +A+ +KL + FK+ + H L+ E
Sbjct: 7656 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAE 7710
Query: 4047 IVNRKKNVDQAIKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSS 4095
+ R K ++ A+ + +LLK T + +++ ++ E+++ ++ ++ ++ S
Sbjct: 7711 QM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7769
Query: 4096 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155
+ + + F +EL WL ++E +++ +G E I + ++ +E
Sbjct: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAI 7828
Query: 4156 VMEHRLVLDTVNE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
E+++ L + E +++A E +A E ++ + N++++ + D I RV ++ +
Sbjct: 7829 AQENKIQLQQMGERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETL 7884
Query: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDS 4271
QQ ++ + W+A + +L PI + ++ +L Q+ DI +H
Sbjct: 7885 VAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7942
Query: 4272 MDELFSHRSEIFGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 4327
+ + + + C + + +Q+ T +L +++ I ++ ER ++E L
Sbjct: 7943 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 8002
Query: 4328 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387
+F + Y W++ + A S + + +++ ++ + + E ++ + K
Sbjct: 8003 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 8062
Query: 4388 GPQLKELNPEEG-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
+L N + +MV E Q+ +N+ ++ +R+ L + Q + D
Sbjct: 8063 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARD 8118
Query: 4443 KIEPMLETLENLSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKR 4497
I L ++ L ++ EC I K+ E+ E +
Sbjct: 8119 SILVWLTEMD----------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 8168
Query: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------E 4538
+GE+LI +S+ D A I+++LD++ + +++ R E +
Sbjct: 8169 QGEQLIEKSEPLD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 8224
Query: 4539 REIKFLDVLELAEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4597
RE++ D L++ W+D +A L + + + ++ L P + + ++I E
Sbjct: 8225 RELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE 8284
Query: 4598 TD---GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654
D L +LE G+ +K + ++ L ++ + L+D
Sbjct: 8285 WDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDD 8344
Query: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQI 4712
+ Q ++ +++ K T P + T L E V+ + ++
Sbjct: 8345 SRFQIQQTENIIRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 8394
Query: 4713 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
+ E+ + G + L +T I R WE L + ++ +++ L QF
Sbjct: 8395 KEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQQF 8445
Query: 4773 QHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830
L + +WL TEE L+ + +S D + IE+++ K L+ V +A + ++N
Sbjct: 8446 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 8505
Query: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890
E ++ + ++ L+ RL MN W+ V EE LQ L Q QGFH LL
Sbjct: 8506 SPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 8564
Query: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS 4950
L ++ + + P E L H + Q+K ++LL+ + +D S
Sbjct: 8565 MLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQDMS 8616
Query: 4951 GSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLTLA 5005
+ LE +K HV+ ++++ + S+ + L + +S Q+ +W +
Sbjct: 8617 CQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSAD 8676
Query: 5006 E 5006
E
Sbjct: 8677 E 8677
Score = 259 bits (662), Expect = 6e-68
Identities = 702/3873 (18%), Positives = 1521/3873 (39%), Gaps = 499/3873 (12%)
Query: 1819 NIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPA 1878
NI KQ P ++ L D L LE + L +L+ + + +++ Q
Sbjct: 4366 NIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQ---- 4421
Query: 1879 QLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWV 1938
++K + Q ++ +SD R + A+ EKT+ L Q ++Q +
Sbjct: 4422 ----VIQKALSDAQSHVNCLSDLVGQRRKYLNKALS-EKTQFLMAVFQATSQIQQHERKI 4476
Query: 1939 GNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFI-----SE 1993
+ ++CL + KQ + AQ + + E
Sbjct: 4477 MFRE-----------------HICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4519
Query: 1994 HAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQ--------------ME 2039
++++ Q+ ++L L ELQ + +L++ + ++ L+ +L ++
Sbjct: 4520 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4579
Query: 2040 QEALVK----TLQKQQNTCHQQL---EDLCSWVGQAERALAGHQGRTTQQDLSALQK-NQ 2091
Q +V L + + H QL +++ + E L Q RT Q L +L + +
Sbjct: 4580 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQ-RTGQTILPSLNEVDH 4638
Query: 2092 SDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEE 2151
S L + + + + + KD F + + L+ +E +L E Q+ + EA +
Sbjct: 4639 SYLSEKLNALPRQFNVIVALAKD--KFYKVQEAILARKEYASLIELTTQSLSELEA--QF 4694
Query: 2152 TRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG-----GQLLT 2206
R+++ + AV AL + E+A + +D L S+G ++L
Sbjct: 4695 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4754
Query: 2207 NLPGMEQLSGASLEKGAL--DTTDGYMGVNQAPEKLDKQCEMMKAR----HQELLSQQQN 2260
+ +L + ++ +L DTT Y + ++L++Q + +K ++E L ++
Sbjct: 4755 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEK 4814
Query: 2261 FILATQSAQAFLDQ---------HGHNLTP--------EEQQMLQQKLGELKEQYST--- 2300
+ A + D H +L P + + +Q GELK S
Sbjct: 4815 LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGE 4874
Query: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360
++ + E+ + Q Q E+ + L WL R + EL + + + +++
Sbjct: 4875 TVTECESRMVQSIDFQTEMSRSLD-------WLRRVKAELSGPVYLDLNLQDIQEEIRKI 4927
Query: 2361 GSFSEDV---------ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDA 2411
E+V +SHK +F D+E+S E SE+ +++ L+
Sbjct: 4928 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE---LSELDGDIQEALRTR 4984
Query: 2412 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGV 2471
T ++S+C R Y FQ + D L+ + + L ++ +
Sbjct: 4985 QATLTEIYSQCQRY----------YQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKS 5034
Query: 2472 LQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSL 2531
E +T Q L E V L + + + + +++ S+ Q +
Sbjct: 5035 HMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKED---------LEQKVASLELRSQRM 5085
Query: 2532 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNL-EGKQVSSLSSGVIQEALATN 2590
S + LLQ+ AQ Q++ E +++ + + E+ L E + + SS +E L+ +
Sbjct: 5086 SRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEH 5145
Query: 2591 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2650
L + + A E ++ +T + + A L + V QR+ +L Q++E
Sbjct: 5146 KALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKI 5205
Query: 2651 LKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQ---DITHFFQQIQELNLEMEDQQ 2707
L+ + + F + K + ++ L + ++ + LE+E QQ
Sbjct: 5206 LEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQ 5265
Query: 2708 ENLDTLEHLVTELSSCGFA----------LDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2757
L L + G A ++ QDR N+++ K VK+ KD
Sbjct: 5266 SALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDR 5325
Query: 2758 SSCQEQLDEFRKLVRTFQKWLKETEGSIP-PTETSMSAKELEKQIEHLKSLLDDWASKGT 2816
+ Q++ + W++ET+ + PT E++ Q+E L+ LL +
Sbjct: 5326 EMVETQINSVKC-------WVQETKEYLGNPTI------EIDAQLEELQILLTE------ 5366
Query: 2817 LVEEINCKGTSLENLIMEITAPDSQGKTG--SILPSVGSSVGSVNGYHTCKDLTEIQCDM 2874
T+ I ++ + G +ILPS S L E+ D+
Sbjct: 5367 --------ATNHRQNIEKMAEEQKEKYLGLYTILPSELSL-----------QLAEVALDL 5407
Query: 2875 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2934
+ +K+ V + S Q + +++++ K+ ++L L++K
Sbjct: 5408 KIRDQIQDKIKEVEQSKATS-QELSRQIQKLAKDLTTILTKLKAK--------------- 5451
Query: 2935 TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWE 2994
T+ V K EL+ + K+ ++ A+ L N Q + K +L +
Sbjct: 5452 TDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQ--NGQLGKPLAKKIGKLTELHQ 5509
Query: 2995 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ 3054
+ R +L ++ASHL + + W+ + + VL +I N + ++Q
Sbjct: 5510 QTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK----VLAHGTIAWNSASQLREQ 5565
Query: 3055 V---QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKL 3111
Q +L+E + + E + E Q + + T ++ +++ + ++ EL +
Sbjct: 5566 YILHQTLLEESKEIDSELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEELRQMI 5620
Query: 3112 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE----AVKQQLEETS 3167
R + A +++ L+ L L A T PE ++K+QL
Sbjct: 5621 KIRLQNLQDAAKDMKKFEAELKKLQAA-------LEQAQATLTSPEVGRLSLKEQLSHRQ 5673
Query: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQG----LEDLAAD 3223
+ S++E L +V+ Q LC ++ I E + L AL LQ L+ A
Sbjct: 5674 HLLSEMESLKPKVQAVQ-LCQS-ALRIPEDVVAS---LPLCHAALRLQEEASRLQHTAIQ 5728
Query: 3224 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEE----- 3278
+ N +QAA+ +Q++Q L+ ++ + ++ ++ LQ+Q+ +EE
Sbjct: 5729 QCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKI 5788
Query: 3279 --FQKSLNQHSGSYEVIV--AEGESLLLSVPP----GEEKRTLQNQLVELKNHWEELSKK 3330
+Q+ + + +++ A+ ++LL+V E L +L+ + +
Sbjct: 5789 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMM 5848
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAML 3389
TA R L L P E+ + + ++ P + S + + A +
Sbjct: 5849 TAGRCHTL----------------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV 5892
Query: 3390 NE---VEKRRSLLEILNSAADILINSS---EADEDGIRDEKAG----INQNMDAVTEELQ 3439
N+ + S + AA I ++S E E G+ + ++ + + +
Sbjct: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVIS 5952
Query: 3440 AKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVL 3499
K +L E +R +++Q+S ++I K+E +L++ ++ + + +A + +
Sbjct: 5953 EKQRTLYEALERQQKYQDSLQSISTKMEAI--ELKLSESPEPGRSPESQMAEHQALMDEI 6010
Query: 3500 QALEPQVDYLR-NFTQGLVEDAPDGSDASQLLHQA--EVAQQEFLEVKQRVNSGCVMMEN 3556
L+ +++ L+ + + LV ++ + A QL Q+ V + ++ + + ++E
Sbjct: 6011 LMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEE 6070
Query: 3557 KL----------EGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFL 3606
KL + + ++ C E+ S L LD + ++ +++Q+ D + L
Sbjct: 6071 KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNML 6130
Query: 3607 NKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELT 3666
++IE + L L G + + GKL R K +L+
Sbjct: 6131 -------VEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKL-RRLKGSLLELQRA 6182
Query: 3667 LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKL 3726
L K LN TA E+ E+ + T+ + + LA + +Q Q L
Sbjct: 6183 LHD--------KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ---RQSSL 6231
Query: 3727 QQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQL------QEALLH 3780
QQ + ++E+ A +L + VA R ++ E
Sbjct: 6232 QQ---------------------QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGD 6270
Query: 3781 CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
G+ D L L + E+ A + + + +QKLLQ +L+ + V L
Sbjct: 6271 AGEKPDVLSQELG--MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV--LY 6326
Query: 3841 AEGGRIAQSAEL-------ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQF 3893
+ R+ L D+ +T L+ L + E+ S++ ++Q + L ++
Sbjct: 6327 SRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIHLEQKL 6383
Query: 3894 HETAEPISDFLSVTEKKLANSE---PVGTQTAKIQQQIIRH--KALEEDIENHATDVHQA 3948
++ S +L E++L + P T+T Q+I+ K + E+++ + QA
Sbjct: 6384 YDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA 6443
Query: 3949 VKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008
+ + V+ + + L R S + ++ + + L F D
Sbjct: 6444 FP--------ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKV 6495
Query: 4009 VLNWLAE----VEDKLSSVFVKDFKQDVLHRQHADH--LALNEEIVNRKKNVDQAIKNGQ 4062
+ LA+ + KL++VF + + + Q A+ + I+ K+ D +
Sbjct: 6496 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGD------K 6549
Query: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 4122
++Q + +E+ +Q+ Y ++ + L Q L ++++ ++L L
Sbjct: 6550 LQVEQPSMQELSKLQD-------MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLL 6602
Query: 4123 REVEEELATSGGQS---PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 4179
+E++A G Q + E+I Q + KE + + H ++ +T + R ++
Sbjct: 6603 ETGQEKMA--GDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTET---LFRKIISFAVQ 6657
Query: 4180 RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLM 4239
+ + +L++ A+ K +R E++ ++ ++ + + +
Sbjct: 6658 KETQFHTELMAQASAVLKRAH----KRGVELEYILETWSHLDEDQQELSRQLEVVESSIP 6713
Query: 4240 ALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ---E 4296
++G + +D+ ++ + + K S++E ++ +++ + ++ ++
Sbjct: 6714 SVGLVEENEDRLIDRITLYQHL-------KSSLNE---YQPKLYQVLDDGKRLLISISCS 6763
Query: 4297 KTESLIQQYEAISLLNSERYAR-LERAQVLVNQFWETYE----ELSPWIEETRALIAQLP 4351
ES + Q L N+ + ++ L R + ++ + W Y+ +L W++ + +
Sbjct: 6764 DLESQLNQLGECWLSNTNKMSKELHRLETIL-KHWTRYQSESADLIHWLQSAKDRLEFWT 6822
Query: 4352 SPAIDHEQLRQQQEEMRQLRESIAEHKPHID-------KLLKIGPQLKELNPEEGEMVEE 4404
++ + Q+ E +R + E +D +L G QL L + +
Sbjct: 6823 QQSV---TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRS 6879
Query: 4405 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464
+ + ++ + + + A+ E + Q DK+ E +S M +I
Sbjct: 6880 ELSRIDSQWTDLLTNIP----AVQEKLHQLQM-----DKLPSRHAISEVMSWISLMENVI 6930
Query: 4465 PAEVDKIRECISDNKSATVELEKLQPSFEA---LKRRGEELIGRS--QGADKDLAAK--- 4516
+ D I+ I K+ L+K + F+ K+ + + +S Q + +D+ +K
Sbjct: 6931 QKDEDNIKNSIG-YKAIHEYLQKYK-GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD 6988
Query: 4517 --EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDL 4574
+ ++L M W+ ++ E+ +LE ++ ++ L T + + +
Sbjct: 6989 KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQ 7048
Query: 4575 ESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEM 4634
G D + ++ ++ + +++ +E+E I G LI E V ++ E+
Sbjct: 7049 HRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLREL 7107
Query: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIK----LCTMPPVGTDL 4690
W NL+ + +L+ +++ + + + FD +++ +++ L + L
Sbjct: 7108 GQTWANLD----HMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSL 7163
Query: 4691 NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN 4750
V+ Q++ ++ + ++ +Q+ ++K +LK+ + + L E+ W N
Sbjct: 7164 EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV-TETLTNTLKEVNMRWNN 7222
Query: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
L E+IA + + L +++ ++ S + E+ + + + + + E+A
Sbjct: 7223 LLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATW 7282
Query: 4811 HVLKNDVLAHQATVET----VNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
ND+L TV+ +++ G +L + AS+++S +++Q ++ Q +
Sbjct: 7283 IQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCK 7342
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926
++ LQ+ + + F +E + E L P+ L T E +L
Sbjct: 7343 QQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHS------SDLSTIQERMEEL 7396
Query: 4927 KAKEETYNQLL-DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEAL 4985
K + ++ + D RL L K + + L + W ++SS+ ER SKL+ L
Sbjct: 7397 KGQMLKFSSMAPDLDRLNELGY-RLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFL 7455
Query: 4986 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIE 5045
F + ++ +L EQ L + + +L Q H++F E+ + + +
Sbjct: 7456 LQHQTFLEKCETWMEFLVQTEQKLAVEISGN--YQHLLEQQRAHELFQAEMFSRQQILHS 7513
Query: 5046 LDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWK 5105
+ G +L Q D L + ++W+ V++R+ +R +D ++ +++ E +
Sbjct: 7514 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7573
Query: 5106 KLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEF-QKTLGGKQPVYDTTIRTGRALKE 5164
KL WL + S L P + L +F +K +Q Y T+ G+ L
Sbjct: 7574 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL-- 7631
Query: 5165 KTLLPEDS---QKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWL 5221
LL DS L L E+++KW + + E++ KL L + + ++ L
Sbjct: 7632 --LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL 7689
Query: 5222 YKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGT-------VQVLKRSGRELIE 5274
+ +L++ P H + + A ++ KEL G+ + +LK + I
Sbjct: 7690 RTFKKKLSQSLPDHHE------ELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYI- 7742
Query: 5275 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 5334
S DD + + +++ L +W+ +C ++ ++ + L + VF + L EWL++ E
Sbjct: 7743 -SADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 7801
Query: 5335 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 5394
+ G + + E ++ L ++E + +E ++ + MGE + H + I++
Sbjct: 7802 KVSQNGDILIE-EMIEKLKKDYQEEIAIAQENKIQLQQ---MGERLAKASHESKASEIEY 7857
Query: 5395 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 5454
+ + R++ +L ++L+ L + + + L W+ E+ L +PI
Sbjct: 7858 KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL----AKPIV 7913
Query: 5455 Q---NIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484
N + ++ + E Q ++ + V V
Sbjct: 7914 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASV 7946
Score = 256 bits (654), Expect = 5e-67
Identities = 725/3998 (18%), Positives = 1518/3998 (37%), Gaps = 543/3998 (13%)
Query: 1793 ATQNVFTRQLCLEH-DEKLVSYLSL------LRNIEMRTKQIQPLELNLAE--LQDLLCQ 1843
A+Q V RQL L H E L S+ SL LR T + E +L E L D L
Sbjct: 1856 ASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQN 1915
Query: 1844 AKVLERELKDLTTLVSQ-------------------------ELECVNQIIISQPQEVPA 1878
AK LE L ++S+ E+E + ++ ++ E A
Sbjct: 1916 AKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADA 1975
Query: 1879 Q--LLKALEKDAKNLQKSLSSVSD-TWNSRLLHFQNAVEIEKTKVLNQ-HTQLEGRLQDL 1934
L KA + + L KS+ + + T RL ++ +V NQ +L +L
Sbjct: 1976 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2035
Query: 1935 RAWVGNKNLILNSKGSNSEIDVD-SLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISE 1993
W+ +K + K +VD +N ++D K+ + E + Q L
Sbjct: 2036 -CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI--------- 2085
Query: 1994 HAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNT 2053
++R L+ + +LE ++ + Q + + + +N
Sbjct: 2086 -----------DLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNK 2134
Query: 2054 CHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQK-NQSDLKDLQDDIQNRATSFATVV 2112
+ + +DL ++ + + L S L+K + SD ++ D+++ + V
Sbjct: 2135 MNYKQKDLDNFTSKGKHLL------------SELKKIHSSDFSLVKTDMESTVDKWLDVS 2182
Query: 2113 KDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQEETRVAQ--KELEE 2161
+ +E M+ + LS ++ + R+++ Q E L R + KE E
Sbjct: 2183 EKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFES 2242
Query: 2162 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEK 2221
V + + E +L E K ++ D + + + Q L + + +++ +L+
Sbjct: 2243 EVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEHAKEITEVAKGTLKD 2301
Query: 2222 GALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQELLSQQQNFILATQ 2266
+T +N + E L ++ CE +K +EL SQQ N I +TQ
Sbjct: 2302 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSN-ISSTQ 2360
Query: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK-FLQD 2325
L + H+ E + + + G +K+ + S S+ + +LQ+ L+K F +
Sbjct: 2361 ENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA----SLQESLEKHFSES 2414
Query: 2326 HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVL 2385
+EF+ W ++ + + L + L + + V + L VT GQ +
Sbjct: 2415 MQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY 2474
Query: 2386 DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS 2445
+I + +++++ A E + A +C + L + F++
Sbjct: 2475 --------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2526
Query: 2446 LQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--DI 2503
L W+ E E+ ++ + + E+ +++ L E E L K+++ +
Sbjct: 2527 LNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL 2583
Query: 2504 MEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSI 2563
+ EG A + +L+ Q+L E+ Q A+ + ++++E+L+S+ +
Sbjct: 2584 LSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV 2640
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVT----RFMETAD 2619
++ L + S+L S ++ L + QDI K E M + + +++
Sbjct: 2641 KAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSN 2696
Query: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679
V+Q +L + + + + +S+L+ ++ Q + +L+Q+ME+
Sbjct: 2697 KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESV---- 2752
Query: 2680 ASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL 2739
DQ I H Q L +E L+HL + LS H + L
Sbjct: 2753 ------DQKIEHPLQPQPGL-------KEKFVLLDHLQSILSEAE------DHTRALHRL 2793
Query: 2740 RKDFTEL-QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA-KEL 2797
EL +KT E KD + +E +F ++ ++ +++ E + + A E
Sbjct: 2794 IAKSRELYEKTEDESFKDTAQ-EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEF 2852
Query: 2798 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2857
+ K L W+ K + ++ LI DS+ S L V S
Sbjct: 2853 TDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELI------DSREIGASRLSRVESLAPE 2906
Query: 2858 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2917
V ++ T C++ +H ++L+A W +
Sbjct: 2907 VK-----QNTTASGCEL-------------MHTEMQALRA----------------DWKQ 2932
Query: 2918 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2977
++ V ++ + + V A S + F ++ Q +++ E + LL T+
Sbjct: 2933 WEDSVFQTQSCLEN-----LVSQMALSEQEFSGQVAQ----LEQALEQFSALLKTWAQQL 2983
Query: 2978 EAENWKKIQEELNSRWERATEVTVARQR---QLEESASHLACFQAAESQLRPWLMEKELM 3034
K EE+ W + E+ A Q+ + E+ S L ++L + +
Sbjct: 2984 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQL-------NELCRFSRDLSTY 3036
Query: 3035 MGVLGPLSIDPNMLNAQ-----KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
G + L + N L Q + + Q + + F + +Q A+ D+ +
Sbjct: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
S+V LQ I E + + +++ + K ELL L K +A G +Q
Sbjct: 3097 ISEVSTSLQKIQ----EFLSESENGQHKLNMMLSKG----ELLSTLLTKEKAKG----IQ 3144
Query: 3150 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209
+ ++ E K + S LE L ++K+ + + + ++D L K +
Sbjct: 3145 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE---------VSAEPIQDWLSKTEKM 3195
Query: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
V L DL A R + Q+ Q + +E+ + +L RL
Sbjct: 3196 VHESSNRLYDLPAKRREQ--------QKLQSVLEEIHCY--------------EPQLNRL 3233
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
+ + Q+ E Q + ++ ++++ +L + + LS
Sbjct: 3234 KEKAQQLWEGQAA---------------------------SKSFRHRVSQLSSQYLALSN 3266
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLDPVQLESSLLRSKAM 3388
T ++ SRL + + ++ +++L W+ D + S T D L+S L+ +A+
Sbjct: 3267 LTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEAL 3326
Query: 3389 LN-EVEKRRSLLEILNSAADILINSS-------EADEDGIRDEKAGINQNMDAVTEELQA 3440
L+ + EK + I+ +L N+S + ++D A + +L+
Sbjct: 3327 LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3386
Query: 3441 KTGSLEEMTQRLREFQESFKNIEKKV-EGAKHQLEIFDALGSQACSNKNLEKLRAQQEVL 3499
+R+F ++E + E + E+ D + E++ + +L
Sbjct: 3387 ALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLL 3446
Query: 3500 QALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLE 3559
+ +E + G+ E + L Q+ + +++R E KL
Sbjct: 3447 ETIEVK-------GAGMTEHYVTQLELQDL-------QERYRAIQERAKEAVTKSE-KLV 3491
Query: 3560 GIGQFHCRVREMFSQ-LADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA 3618
+ Q + R + F L ++LD + D + ++ + D++ L++
Sbjct: 3492 RLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQ-------ELQVHCAE 3544
Query: 3619 SEAECRHMLEEEGTLDLLGLK----RELEALNKQCGKLTERGKARQEQLELTLGRVEDFY 3674
+A +L + G+ R LE+L + R + Q + ++
Sbjct: 3545 GQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLME 3604
Query: 3675 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3734
+K + +++ AEE + + + QL K + E+V + ++++V Q
Sbjct: 3605 QKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWH-EEVTAYRDEVEEVGARAQ 3663
Query: 3735 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSW 3794
++ + + + ++ +R+ L +V ++I L+E + + + +L W
Sbjct: 3664 EILDESHVN---SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3720
Query: 3795 LADTEELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDRKATVDMLQA---EGGRIAQS 3849
T + N K + + V + +KL L+ LL D + +L++ +G R +
Sbjct: 3721 YGSTHK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKY 3777
Query: 3850 AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEK 3909
E + E++ ++ + EL S LE L LAK+F + + ++ +++ ++
Sbjct: 3778 LEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3837
Query: 3910 KLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSE 3969
L E + + + Q+ ++K+L++ + +H V + G++L L L +
Sbjct: 3838 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV---TLKD 3894
Query: 3970 KIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-FVKDF 4028
KID LQ+ Y ++ L+ + + + + EV WL ++ +L + ++
Sbjct: 3895 KIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETS 3954
Query: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK----LDGIK 4084
+ + +Q A H A+ EEI + ++ G L+ Q +++ L G K
Sbjct: 3955 SLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTK 4014
Query: 4085 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG----- 4139
Y+ I T+ + ++LE Q Q T ++ WL V+ +L S Q P
Sbjct: 4015 DSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSP-QPPLSRAEAI 4073
Query: 4140 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN-----E 4194
+Q+ F+ Q++ + + + D N + + + + KLV N E
Sbjct: 4074 KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWE 4133
Query: 4195 QYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA--WVAETKRKLMALGPIRLEQDQTT 4252
+ K + + + + D +Q ++ + +A V++ K + +L+ Q +
Sbjct: 4134 EIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK-----KLQSKQAS 4188
Query: 4253 AQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLN 4312
++K + E+ + C + LQ + E L + + +N
Sbjct: 4189 VNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE-EDLQRTRDYHDCMN 4247
Query: 4313 SERYARLERAQVLVNQFWETYEELSPWIEETRAL-IAQLPSPAIDHEQLRQQQEEMRQLR 4371
+V + +F ++ L+ E+ A+ + L A+ ++ + E+++ +
Sbjct: 4248 V--------VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQK 4299
Query: 4372 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAV 4431
+ + EH LN ++ E+V+E+ E + Q+++ ++++ + +V
Sbjct: 4300 QKMIEH----------------LNLDDKELVKEQTSHLEQRWFQLEDLIKRK---IQVSV 4340
Query: 4432 SQSTQITEFHDKIEPMLETLE----NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 4487
+ ++ + + ++E E N++ L+ P D + + D+ + ELE
Sbjct: 4341 TNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP----PPDMAQNLLMDHLAICSELEA 4396
Query: 4488 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4547
Q ++L + + ++ ++ + K + D + + + R K+L+
Sbjct: 4397 KQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRR-----KYLNKA 4451
Query: 4548 ELAEKFWYDMAALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEEL 4605
L+EK + MA T I+ + + E + P + +QV+ ++ + E+
Sbjct: 4452 -LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEV 4510
Query: 4606 EFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDT 4665
+ G +L+ E EK EV + E+ + ++++ + RL++LE + + +++
Sbjct: 4511 TGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKED 4570
Query: 4666 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL----NHQG 4721
WL I T P + +N + ++ +++ + +Q E E L G
Sbjct: 4571 FDKACHWLKQADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQSPEYENLLLTLQRTG 4626
Query: 4722 ELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4781
+ +L + +E D + E L L + + + +K++ A+LA ++ +E
Sbjct: 4627 QTILP-SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE---- 4681
Query: 4782 WLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG- 4840
LT T+ L + +E + + + D+ +A ++ +L+ AG
Sbjct: 4682 -LT-TQSLSE-----------LEAQFLRMSKVPTDLAVEEAL--SLQDGCRAILDEVAGL 4726
Query: 4841 ----DDASSLRSRLEAMNQCWE--------SVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888
D+ + + + Q W+ ++ + + + +Q S L+ + E E
Sbjct: 4727 GEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKM 4786
Query: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML---L 4945
+L R QL + K + +++Y L + +L + + L
Sbjct: 4787 CQQLER---QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLA 4843
Query: 4946 SRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLA 5005
D + K + + + +++S + E ++ E + + +FQ + ++WL
Sbjct: 4844 PHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRV 4903
Query: 5006 EQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLI 5065
+ L+ L L + +I + ++ EV + + L + KF K+ +
Sbjct: 4904 KAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELISAD 4962
Query: 5066 KNLLVSVQSRWEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLIDWLEDA---------- 5114
++ S + +Q ++ R +L + + +++++ ++ DWLEDA
Sbjct: 4963 LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNG 5022
Query: 5115 ------ESHLDSELEISNDPDKIKLQLSKHKEFQKTLG------GK----QPVYDTTIRT 5158
E +L S +E + D+ L + TL GK Q V +R+
Sbjct: 5023 LDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRS 5082
Query: 5159 GRALKEK----------TLLPEDSQK----LDNFLGEVRDKWDTVCGKSVERQHKLEEAL 5204
R ++ T D QK + + + K H+ EE L
Sbjct: 5083 QRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142
Query: 5205 LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQV 5264
+ + + + + +E + ++ + D V+Q R ++
Sbjct: 5143 SEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQ-----RWTRLRA 5197
Query: 5265 LKRSGRELIENSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRLEQA-LKQAEVFRDTV 5322
+ + +++E++ D+ T ++++ + D + KL S + +A L + DT
Sbjct: 5198 VAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTF 5257
Query: 5323 HMLLEWLSEA-----EQTLRFR--GALPDDTEA--LQSLIDTHKEFMKKVEEKRVDVNSA 5373
+ LE A +QTL GA P E L I ++ ++EK V N
Sbjct: 5258 VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEK-VKTNGK 5316
Query: 5374 VAMGEVILAVCHPDCITTIKHWI----------TI-IRARFEEV---LTWAKQHQQRLET 5419
+ E+ I ++K W+ TI I A+ EE+ LT A H+Q +E
Sbjct: 5317 LVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK 5376
Query: 5420 ALSELVANAELLEELLAW---IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476
E L +L +Q AE L + ++ I I V+ A Q ++ +
Sbjct: 5377 MAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQK 5436
Query: 5477 KQPDVDRVTKTYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTPPPMPILSQS----EA 5528
D+ + K K A +K G L + L Q+ +
Sbjct: 5437 LAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKP 5496
Query: 5529 KNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566
+I +L+ QQ A R KLN A LEE E
Sbjct: 5497 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNE 5534
Score = 235 bits (599), Expect = 1e-60
Identities = 570/3191 (17%), Positives = 1235/3191 (38%), Gaps = 398/3191 (12%)
Query: 2543 QKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI----QEALATNMKLKQDIA 2598
Q+ + + +++ + S S+G++ + + + + SS + QE LA K+ +
Sbjct: 811 QQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT 870
Query: 2599 RQKSSLEATREMVT--RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
+ ++ ++ VT ++ D T LQ ++A++ F+ + + + + ++
Sbjct: 871 LIEKGSQSVQKFVTLSNVLKHFDQTR---LQRQIADIHVAFQSMVKKTGDWKKHVETNSR 927
Query: 2657 QAEMFEHLSGKLQQFMENKSRMLASGNQPDQDI---THFFQQIQELNLEMEDQQENLDTL 2713
+ FE +L++ + L P++ + T FF Q+ + L + D L
Sbjct: 928 LMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAF--LKACDEL 985
Query: 2714 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQ----------KTVKEREKDASS---C 2760
++ E G Q+ V+ L K + +LQ K E+ + +S C
Sbjct: 986 TDILPEQEQQGL-------QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEEC 1038
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
+ +LD KL+ P E S EK I+ + D +
Sbjct: 1039 RTELDRETKLM---------------PQEGS------EKIIKEHRVFFSDKGPHHLCEKR 1077
Query: 2821 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2880
+ L + D+ G L + +++ S T + L E D +
Sbjct: 1078 LQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS-----TYRKLMEDPDKWKDYTSR 1132
Query: 2881 YEKLGGVLHERQESLQAILNR-------------MEEVHK---EANSVLQWLESKEEVLK 2924
+ + + + L+ I +EE+ + L WL+S+ +VL
Sbjct: 1133 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLT 1192
Query: 2925 SMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKK 2984
+ + + K A+ S+ L L + +V++ L+ N + +K+
Sbjct: 1193 EVSSENEAQKQGDELAKLSSSFKALVTL------LSEVEKMLS-------NFGDCVQYKE 1239
Query: 2985 IQEELNSRWERATEVTVARQRQLEESASHLA----CFQAAESQLRPWLMEKELMMGVLGP 3040
I + + E ++ ++++E A + F+A + L K
Sbjct: 1240 IVKN-------SLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKR-------- 1284
Query: 3041 LSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSI 3100
I + Q+Q Q E + HE+L + + L G + S + ++ +Q
Sbjct: 1285 --ISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKL-ESTLDG---LERSRERQERRIQVT 1338
Query: 3101 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVK 3160
+KW K T + L Q S R + S ++S++ E K
Sbjct: 1339 LRKWERFETN-------------KETVVRYLFQTGSSHERFLS--FSSLESLSSELEQTK 1383
Query: 3161 QQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL 3220
+ + T I E L VKEA + +G Q K L+++ +++ ++ LED
Sbjct: 1384 EFSKRTESIAVQAENL---VKEAS------EIPLGPQN-KQLLQQQAKSIKEQVKKLEDT 1433
Query: 3221 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQEN-EEF 3279
+ I ++ F F+ L W+ +K+ + S+ ++ SQ++ +E
Sbjct: 1434 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1493
Query: 3280 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 3339
+ L+ G E E +S V GE R ++ +L +++ + EEL + + +
Sbjct: 1494 ESKLSSIVGLEE----EAQSFAQFVTTGESAR-IKAKLTQIRRYGEELREHAQCLEGTIL 1548
Query: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLL 3399
+ + QK++ ++ + + + + K++ P+++ SS + +L E L
Sbjct: 1549 GHLSQQQKFEENLRKIQQSVSEFEDKLAV------PIKICSSATETYKVLQEHMDLCQAL 1602
Query: 3400 EILNSAADILINSSE--ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQE 3457
E L+SA S+ + D E A + Q + + + + +LE +
Sbjct: 1603 ESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAH------ 1656
Query: 3458 SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEV--LQALEPQVDYLRNFTQG 3515
++ +EK++ LE +A S + + ++++ + E+ +QAL+ +V +F
Sbjct: 1657 -WQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK 1715
Query: 3516 LVE------DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVR 3569
L++ D + E + + ++ Q +N +++ + QF +
Sbjct: 1716 LLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLL 1775
Query: 3570 EMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE 3629
+ EL + T + V L +K H ++E+ + E + +
Sbjct: 1776 SFSVWIKLFLSEL-------QTTSEISIMDHQVALTRHKDHAA--EVESKKGELQSLQGH 1826
Query: 3630 EGTLDLLGLKRELEALN---KQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTA 3686
L LG +L L + C +L E E+ +L L + +F + L+
Sbjct: 1827 LAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQ 1886
Query: 3687 AEEA-EALQWVVGTEVEIINQQLADFKMFQKE------QVDPLQMKLQQVNGLGQGLIQS 3739
+ EA + E ++I + L D K +D + K Q +G ++
Sbjct: 1887 LRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT 1946
Query: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
+ + Q L ++E I T + A +A L++A FQD E LL + D E
Sbjct: 1947 SCRATADQ-LCGEVERIQNLLGTKQSE-ADALAVLKKA------FQDQKEELLKSIEDIE 1998
Query: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
E ++ + ++ +++ L+ L+ + + L+ + +IAQ ++A ++
Sbjct: 1999 ERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK-DVAFAPEVD 2057
Query: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLS------VTEKKLAN 3913
++ LE W + Q Q ++ L +++ +S L VT + +
Sbjct: 2058 REINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKD 2117
Query: 3914 SEPVGTQTAKIQQQIIRHKALEEDIENHATD----VHQAVKIGQSLSSLTSPAEQGVLSE 3969
E + +K + + ++D++N + + + KI S SL + + +
Sbjct: 2118 QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDK 2177
Query: 3970 KIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVL--NWLAEVEDKLSSV---- 4023
+D + + E DR ++ D LS DE+E N + ++ + +S++
Sbjct: 2178 WLD-VSEKLEENMDRLRVSLSIWDDVLST-----RDEIEGWSNNCVPQMAENISNLDNHL 2231
Query: 4024 ----FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK 4079
+K+F+ +V ++ L L EE+ ++ ++ + KN + T ++ I+
Sbjct: 2232 RAEELLKEFESEVKNKA----LRL-EELHSKVNDLKELTKNLE------TPPDLQFIEAD 2280
Query: 4080 LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG 4139
L +IT A TL+ +T+ + ++T W +VEE L Q+ T
Sbjct: 2281 LMQKLEHAKEITEV---AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA-QNETC 2336
Query: 4140 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 4199
E + + + QKEL+ + + +N + R E L + ++ ++++ V
Sbjct: 2337 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSA----ELESLGRAMTGLIKKHEAV 2392
Query: 4200 SDTIGQRVDEIDAAIQRS--QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQV 4257
S Q + A++Q S + + ++ W K E T +V
Sbjct: 2393 S----QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK-------ESSDRTGDSKV 2441
Query: 4258 QKAFSIDIIRHKDSMDE--------------LFSHRSEIFGTCGEEQKTVLQEKTESLIQ 4303
+A D+ DS+ + L++H S+ + +EQ T E+ ++ ++
Sbjct: 2442 LEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLK 2501
Query: 4304 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 4363
Q ++ A + A L F + + +L+ WI E + + + ++
Sbjct: 2502 Q------CLKDKQALQDCASEL-GSFEDQHRKLNLWIHEMEERF-NTENLGESKQHIPEK 2553
Query: 4364 QEEMRQLRESIAE---HKPHIDKLLKIGPQLKELNP---EEGEMVEEKYQKAENMYAQIK 4417
+ E+ ++ + E + +DKL + G L E +EG + + +N+ K
Sbjct: 2554 KNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTK 2613
Query: 4418 EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISD 4477
E++R +AL E + + ++ + + L S L + + +I++ +
Sbjct: 2614 EKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLM 2673
Query: 4478 NKSATVELEK-LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4536
V+L + +AL+ +E + IQ +L+ + W DI + +
Sbjct: 2674 KGEGEVKLNMAIGKGEQALRSSNKE------------GQRVIQTQLETLKEVWADIMSSS 2721
Query: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKD-----TQDIVHDLE-SPGIDPSIIKQQVEA 4590
+ LE W D ++ Q I H L+ PG+ + ++
Sbjct: 2722 VHAQ----STLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVL--LDH 2775
Query: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI-DEMNNAWENLNKTWKERL 4649
++I E + L + +L +TE + + +E+ + ++ KE++
Sbjct: 2776 LQSILSEAEDHTRALHRLIAKSRELY---EKTEDESFKDTAQEELKTQFNDIMTVAKEKM 2832
Query: 4650 EKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ 4709
K+E+ ++ + Y D + DWL + +L + D + + +L+++KE +
Sbjct: 2833 RKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKEL---IDS 2889
Query: 4710 QQIEMEKLNHQGELM--LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4767
++I +L+ L +K+ T + +++ + L+ W+ + + Q LE +
Sbjct: 2890 REIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVS 2949
Query: 4768 ALG-----------QFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKND 4816
+ Q + ALE+ + L + L + D +++E +L
Sbjct: 2950 QMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDAL 3009
Query: 4817 VLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQ 4876
A T E + NEL S D S+ ++ + + + + + + Q + LQ
Sbjct: 3010 QKAEPRT-EDLKSQLNELCRFSR--DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ 3066
Query: 4877 QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE---QLDTHMELYSQLKAKEETY 4933
Q F DF L + ++++ +K +P+ E L E S+ + +
Sbjct: 3067 QR--FRKAFRDFQQWL--VNAKITTAK-CFDIPQNISEVSTSLQKIQEFLSESENGQHKL 3121
Query: 4934 NQLLDKGRLM--LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEF 4991
N +L KG L+ LL+++ + + V ++ W S + +++S LE +F
Sbjct: 3122 NMMLSKGELLSTLLTKEKAKG---IQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDF 3178
Query: 4992 QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 5051
+ S + +WL+ E+ ++ +S L + ++ + E++ + Q+ L +
Sbjct: 3179 EVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQ 3238
Query: 5052 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWL 5111
QL + ++ + + S++ + + E+ LD QF K+L DW+
Sbjct: 3239 QL--WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWM 3296
Query: 5112 EDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPED 5171
DA LDS ++D + + K + K+ + G ++ + T PE
Sbjct: 3297 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS-PEG 3355
Query: 5172 SQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAED 5231
+ L V+D W ++ + + +LE AL + D ++ W+ +E L E
Sbjct: 3356 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNES 3415
Query: 5232 QPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELS 5291
+ H +L ++ K+ +E+ + ++ ++ G + E+ +LQ+L
Sbjct: 3416 ERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQL-----ELQDLQ 3470
Query: 5292 TRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQS 5351
R+ + + + ++ E+ ++ + ++ + WL + ++ L D L+
Sbjct: 3471 ERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKL-------DQYSVLEG 3523
Query: 5352 LIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAK 5411
TH+ ++ ++E +V A G+ +L +++ R + + +
Sbjct: 3524 DAHTHETTLRDLQELQVHC----AEGQALLN--------------SVLHTREDVIPSGIP 3565
Query: 5412 QHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFM 5471
Q + R AL L + + + L+ + ++ + + Q +V + + +
Sbjct: 3566 QAEDR---ALESLRQDWQAYQHRLSETRTQFNNVVNK-LRLMEQKFQQVDEWLKTAEEKV 3621
Query: 5472 EEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5531
TR+Q + R TK + ++ H + + R + + IL +S +
Sbjct: 3622 SPRTRRQSN--RATKEIQLHQMKKWH-----EEVTAYRDEVEEVGARAQEILDESHVNSR 3674
Query: 5532 ---RINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKS 5588
+ QL++R+Q + L LE+ + L + + LEE + + Y W
Sbjct: 3675 MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLS--------SYSDWYGSTHK 3726
Query: 5589 RVMDFFRRIDK 5599
+ +IDK
Sbjct: 3727 NFKNVATKIDK 3737
Score = 225 bits (573), Expect = 1e-57
Identities = 563/3336 (16%), Positives = 1277/3336 (38%), Gaps = 328/3336 (9%)
Query: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKE 2158
+ +QN + K+++ ++E+ + L+ ++ + L + ++ + + + +K+
Sbjct: 307 NSVQNFKREDRVIFKEMKVWIEQFERDLTRAQM--VESNLQDKYQSFKHFRVQYEMKRKQ 364
Query: 2159 LEEAVTSALQQETEKSKAAKELAENKKKIDA-LLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
+E + L ++ + S + ++ ++ + L DW QL +LP GA
Sbjct: 365 IEHLI-QPLHRDGKLSLDQALVKQSWDRVTSRLFDWHI-------QLDKSLPAPLGTIGA 416
Query: 2218 SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH 2277
L + + + + V Q E+ + +H++LL A +G
Sbjct: 417 WLYRAEVALREE-ITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGI 475
Query: 2278 NLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSE 2337
+ P++ L ++ E++ + SE L +++ FL+ S L +E
Sbjct: 476 PVPPDQ-------LEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAE 520
Query: 2338 KELENMHKGGSSPETLPSLLKRQGSFSED---VISHKGDLRFVTISGQKVLDMENSFKEG 2394
+L++ E++ LL+ SF E+ ++ + + + + + + S +E
Sbjct: 521 SKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA 580
Query: 2395 KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE 2454
+ + N + T ++ L + + S L ++ + ++ N+ SLQAW++ E
Sbjct: 581 ENVMKFMN-------ETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAE 633
Query: 2455 ANV---EKLLSDTVASDPGVLQEQLATTK------QLQEELAEHQVPVEKLQKVAR---D 2502
+ E D + P +Q+ A + +E+ + + L R
Sbjct: 634 KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWREL 693
Query: 2503 IMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
ME++ D R +E TD ++ +LS E L + + S +++ L+
Sbjct: 694 FMEVKQYAQADEMDRMKKEYTDCVV----TLSAFATEAHKKLSEPLEVSFM---NVKLLI 746
Query: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2620
Q + ++EQ + + +A + + ++S E +EM
Sbjct: 747 QDLEDIEQRVP-----------VMDAQYKIITKTAHLITKESPQEEGKEMF--------- 786
Query: 2621 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2680
T + L+ +L +V + + L + Q+ L++L Q F GK+ + + R
Sbjct: 787 ATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLER--- 843
Query: 2681 SGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLR 2740
Q F Q+ QEL E+ ++ L +E + ++ +H D+
Sbjct: 844 ----EAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ----- 894
Query: 2741 KDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQ 2800
T LQ+ + + S ++ +++K V T + +K+ E S ELEK
Sbjct: 895 ---TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFE---------ESRAELEKV 942
Query: 2801 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2860
+ + L++ L+ + L+ ++
Sbjct: 943 LRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAF------------------------ 978
Query: 2861 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA-----ILNRMEEVHKEANSVLQW 2915
C +LT+I + L ++ LH++ + LQ +L+ +V K ++
Sbjct: 979 LKACDELTDILPEQEQQGL--QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKN-----RF 1031
Query: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQN---SPKIQKVKEALAGLLVT 2972
L S EE +D + E + + ++ F ++ + ++Q ++E L V
Sbjct: 1032 LASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVR 1091
Query: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
P +EL + + + R+L E + + S+ W+ E
Sbjct: 1092 DPVRDTPGTCHVTLKELRAAID-------STYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1144
Query: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 3092
+ + +ID K+ V+ + R + L + +LT +VS S ++
Sbjct: 1145 TQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLK-VLT---EVS-SENE 1199
Query: 3093 VQK---ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
QK EL ++ + L L+ + QY+E++++ E++ + + + Q
Sbjct: 1200 AQKQGDELAKLSSSFKALVTLLSEVEKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQ 1258
Query: 3150 S--AISTQPEAVKQQL-----EETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
+ + T+ QQL ++T I + + ++ +AQ GE L D
Sbjct: 1259 AEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQ---------GEGGLPDR 1309
Query: 3203 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 3262
+ L + L GLE + R+Q L ++F+ + + +L S +
Sbjct: 1310 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1369
Query: 3263 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 3322
S+ LE L S+L++ +EF K + E +V E + L + K+ LQ Q +K
Sbjct: 1370 SS-LESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLG---PQNKQLLQQQAKSIKE 1425
Query: 3323 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 3382
++L + ++ K + + E L WI + + +++ L + + ++ S
Sbjct: 1426 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1485
Query: 3383 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDG-IRDEKAGINQNMDAVTEELQAK 3441
+ K + E+E + S + L A E I+ + I + + + E Q
Sbjct: 1486 I--KVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL 1543
Query: 3442 TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA 3501
G++ + ++F+E+ + I++ V + +L + + S A + + L+ ++ QA
Sbjct: 1544 EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSA--TETYKVLQEHMDLCQA 1601
Query: 3502 LEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
LE + F+ A + + +A QQ++ ++ +R +EN L
Sbjct: 1602 LESLSSAITAFS----ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLL--- 1654
Query: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA 3621
+ +E+ S L L+ + D + + ++E L I L+ ++ + +
Sbjct: 1655 AHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGE---LQLIQALQNEVVSQAS 1711
Query: 3622 ECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3681
+L+ + +L + K +++ + +L ER + + + + ++ + + +
Sbjct: 1712 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1771
Query: 3682 DATTAAEEAEAL---QWVVGTEVEIINQQLADFK--------MFQKEQVDPLQMKLQQVN 3730
+ + L + +E+ I++ Q+A + +K ++ LQ L ++
Sbjct: 1772 ELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLG 1831
Query: 3731 GLGQG----LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF-- 3784
LG+ L+Q +DC L ++ +Q + + Q AL H +F
Sbjct: 1832 SLGRAEDLHLLQGKAEDC----------------FQLFEEASQVVERRQLALSHLAEFLQ 1875
Query: 3785 -QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
+L +L L T E A E +++ + + + L+ ++D + ++
Sbjct: 1876 SHASLSGILRQLRQTVE--ATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKA 1933
Query: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
+ R + L + + +Q + + + VL K F + E +
Sbjct: 1934 QYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKS 1993
Query: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV----HQAVKIGQSLSSLT 3959
+ E++ +QQ++ LE+++ +H ++ +A +I Q +
Sbjct: 1994 IEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFA 2053
Query: 3960 SPAEQGV--LSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
++ + L D + E Q +CC L+ + + + +++V
Sbjct: 2054 PEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM-----------REYQNLKSAVSKVL 2102
Query: 4018 DKLSSVFV-----KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTT 4069
+ SSV V KD Q+ L + H ++ ++K++D G+ L LK+
Sbjct: 2103 ENASSVIVTRTTIKD--QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2160
Query: 4070 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW----LREV 4125
+ L++ ++ ++ D++ + + L + + ST +E+ GW + ++
Sbjct: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2220
Query: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
E ++ E + +F + E+K + + + VN++ L + +
Sbjct: 2221 AENISNLDNHLRAEELLKEF---ESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFI 2277
Query: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
+ + E K +++ + + A +S Q E+ + W + + LM
Sbjct: 2278 EADLMQKLEHAKEITEVAKGTLKDFTA---QSTQVEKFINDITTWFTKVEESLM-----N 2329
Query: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
Q++T L+ K ++ + ++ + + + + L LI+++
Sbjct: 2330 CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKH 2389
Query: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE 4365
EA+S L S+ A L+ + L F E+ +E W +A + D + L +
Sbjct: 2390 EAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2447
Query: 4366 EMRQLRESIAEHKPHIDKLLKIGPQL-KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
+++ + +S+++ + +D + + G L L+ + ++E+ KA + ++ +
Sbjct: 2448 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2507
Query: 4425 LALDEAVSQSTQITEFHDKIEPMLETL------ENLSSRLRMPPLIPAEVDKIRECISDN 4478
AL + S+ + H K+ + + ENL + P EV K+ + +
Sbjct: 2508 QALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGEL 2567
Query: 4479 KSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEE 4538
+A L+K L +RG+ L GA ++ Q++ +++ +E
Sbjct: 2568 LAARESLDK-------LSQRGQLLSEEGHGAGQE------GRLCSQLLTSHQNLLRMTKE 2614
Query: 4539 REIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP-GIDPSIIKQQVEAAETIKEE 4597
+ L+ E + ++ +K QD + ES G ++ K+ + + + +
Sbjct: 2615 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2674
Query: 4598 TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQ 4657
+G +L G + + + + ++ ++ + W ++ + LE +
Sbjct: 2675 GEG-EVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVIS 2733
Query: 4658 AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL 4717
Y + + W+++ K+ L L+ ++ E + +L
Sbjct: 2734 QWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRL 2793
Query: 4718 NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE 4777
+ + +K DE+ +D +E ELK + ++ + K+E + + A+
Sbjct: 2794 IAKSRELYEKTEDESFKDTAQE---ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2850
Query: 4778 ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837
E WL +E L +SGD + +L+K L + + + V E+ ++
Sbjct: 2851 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2910
Query: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897
+ + + ++A+ W+ + + L++ + Q E + +L +
Sbjct: 2911 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2970
Query: 4898 QLSASKPTGGLPETAREQLDTHME-----------LYSQLKAKEETYNQLLDKGRLMLLS 4946
Q SA T T E +T E L + KA+ T + L S
Sbjct: 2971 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3030
Query: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
RD S K V+ L ++++ + + + E+ L F+ + ++F WL A+
Sbjct: 3031 RDLSTYSGK----VSGLIKEYNCLCLQASKGCQNKEQILQ--QRFRKAFRDFQQWLVNAK 3084
Query: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
+ ++ V + +++ + F +E + ++ + G L L K+ I+
Sbjct: 3085 ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQ 3144
Query: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
+ + + W+ ++ +L++ + + K F + + + DWL E +
Sbjct: 3145 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEK------MVHE 3198
Query: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF---LGEVR 5183
+++ +K +E QK + ++ + R ++ L E +F + ++
Sbjct: 3199 SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLS 3258
Query: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD---L 5240
++ + + E+ +L+ + QF ++ L DW+ L D H D L
Sbjct: 3259 SQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHML--DSYCHPTSDKSVL 3316
Query: 5241 VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKL 5300
+ + + K ++ R L S + ++ QLQ + W ++
Sbjct: 3317 DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA 3376
Query: 5301 SVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336
+ +S+LE AL + ++D V W+ E L
Sbjct: 3377 GIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
Score = 209 bits (533), Expect = 5e-53
Identities = 572/3039 (18%), Positives = 1174/3039 (38%), Gaps = 425/3039 (13%)
Query: 1566 PSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLK 1625
PS ++ TD S Q+ Y + + + +I S ++ Y E +P+ K
Sbjct: 5882 PSPVANTDAS----VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFY-EPGLEPSATAK 5936
Query: 1626 LEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANP 1685
L ++ S K V S+++ ++ + K +L+S E K E P
Sbjct: 5937 LGDLQRSWETLKNV----ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5992
Query: 1686 N------VAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLET 1739
+A +A E ++ Q L S L E+L + + Q L
Sbjct: 5993 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQ---------LAL 6043
Query: 1740 SEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFT 1799
TV S ++ + + + +L E ++Q E R Q
Sbjct: 6044 QSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL----------------EEQRQEQ-ALQ 6086
Query: 1800 RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVS 1859
R C E DE L S+L L + T P E E Q + CQ ++E E K +
Sbjct: 6087 RYRC-EADE-LDSWL-LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK---VVAL 6140
Query: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQN-AVEIEKT 1918
EL N+ ++ + + + L + L+ SL + + + L+ Q A E E++
Sbjct: 6141 SELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEES 6200
Query: 1919 KVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA 1978
V TQ G ++ W+ + +S LQQ ++L+Q +AE+K+
Sbjct: 6201 DVDLTATQSPG----VQEWLAQARTTWTQQRQSS----------LQQQKELEQELAEQKS 6246
Query: 1979 QLDALAFDIQFFISEH-AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQ 2037
L ++A + + +H A + S + L EL E+++A+ D ++ +
Sbjct: 6247 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG----EKSSAE-DQMRMKWES 6301
Query: 2038 MEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAG---HQGRTTQQDLSALQKNQSDL 2094
+ QE K + QN Q+ E + + R L+G ++G QD SA+ L
Sbjct: 6302 LHQEFSTKQ-KLLQNVLEQEQEQVL--YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGL 6358
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRV 2154
+++ +++ A R+ +H ++ Y+ + T
Sbjct: 6359 NQAFEEVSSQSGG-------------------------AKRQSIHLEQKLYDGVSA-TST 6392
Query: 2155 AQKELEEAV---TSALQQETE-----KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206
++EE + T+ L +ETE + AK++ E +++D + + G
Sbjct: 6393 WLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD--- 6449
Query: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQ 2266
N +E G L G L D VNQ +C MK R Q++L+ Q + +
Sbjct: 6450 NRDVIEDTLGCLL--GRLSLLDSV--VNQ-------RCHQMKERLQQILNFQNDLKVLFT 6498
Query: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTSLAQSEAELKQVQTLQDELQ--- 2320
S L + + + + + +Q + E E Q L + +A + +++ D+LQ
Sbjct: 6499 S----LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ 6554
Query: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH-----KGDLR 2375
+Q+ + + + + + G + TL S +R D++ GD +
Sbjct: 6555 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 6614
Query: 2376 FVTISG---QKVLDMENSFKEGKEPSEI--GNLVKDKLKDATERYTALHS---------- 2420
+ S Q++LD + +G E I L + + A ++ T H+
Sbjct: 6615 IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVL 6674
Query: 2421 -KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATT 2479
+ + G L +L + L ++ E+++ + V + L +++
Sbjct: 6675 KRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV--GLVEENEDRLIDRITLY 6732
Query: 2480 KQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERS 2539
+ L+ L E+Q + ++ + ++ I + + + + LS+ +S L
Sbjct: 6733 QHLKSSLNEYQPKLYQVLDDGKRLL-ISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791
Query: 2540 SLLQK----------AIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALAT 2589
++L+ I QS ++ LE Q V Q LE ++++ L
Sbjct: 6792 TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE----------MVRDHLNA 6841
Query: 2590 NMKLKQDIARQ---KSSLEATREMVTRFMETADSTTAAVLQG----------KLAEVSQR 2636
++ +++ Q KSS+ +T + R + +T + L + V ++
Sbjct: 6842 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 6901
Query: 2637 FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI 2696
QL + + ++ +++ + E++ K + ++N A I + Q+
Sbjct: 6902 LHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--------IHEYLQKY 6953
Query: 2697 QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL---RKDFTELQKTVKER 2753
+ +++ +Q +D + V ++SS D + L K + LQ V E+
Sbjct: 6954 KGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK 7013
Query: 2754 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS 2813
+ E E+ V+ + W + E + ++ ++ + L D +
Sbjct: 7014 IQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKA 7073
Query: 2814 KGTLVEEINCKGTSL--------ENLIMEITAPDSQ---------GKTGSILPSVGSSVG 2856
K VE+I G +L +++M Q G+ +L SV
Sbjct: 7074 KEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS 7133
Query: 2857 S-------VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909
S +N Y L E + +S ++ L G L Q + + N +++ K+
Sbjct: 7134 SHKVAFDKINSY-----LMEARYSLS----RFRLLTGSLEAVQVQVDNLQNLQDDLEKQE 7184
Query: 2910 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2969
S+ ++ ++LK + T T T+K E N + LE+ + ++Q K L
Sbjct: 7185 RSLQKFGSITNQLLKECHPPVTETLTNTLK---EVNMRWNNLLEEIAEQLQSSKALL--- 7238
Query: 2970 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 3029
Q + +K ++ S ++ + R +L ++A++ A+ ++ W+
Sbjct: 7239 -------QLWQRYKDYSKQCASTVQQQED----RTNELLKAATNK---DIADDEVATWIQ 7284
Query: 3030 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
+ ++ LG + K + F+ + E +QQ + + +
Sbjct: 7285 DCNDLLKGLGTV----------KDSLFFLHELGEQLKQQVD----------------ASA 7318
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
S +Q + S++Q L L + + + ++ + + L+ L + + L Q
Sbjct: 7319 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 7378
Query: 3150 --------SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 3201
S I + E +K Q+ + S + DL++L+ EL + L D
Sbjct: 7379 DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN-----------ELGYRLP---LND 7424
Query: 3202 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK-QSQQAKNC 3260
+ KR++ + + +R ++LQ+ L Q F ++ TW++ Q++Q
Sbjct: 7425 KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAV 7481
Query: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
IS + L Q + +E FQ + I+ +G+ LL +++ +L L
Sbjct: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL-EQGQVDDRDEFNLKLTLL 7540
Query: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW-IEDCKAKMSELRVTLDPVQLE 3379
N W+ + ++ R+ + +++ Q+Y+ E L W +E MS L P+Q
Sbjct: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
Query: 3380 SSLLRSKAMLNEVEKRR--SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEE 3437
+L +V R+ S + + + +L+++ E ++ E A I E+
Sbjct: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ-------EK 7653
Query: 3438 LQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQE 3497
++ + LEE ++L + ++ EK + + +L F SQ+ + + E+L A+Q
Sbjct: 7654 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EELHAEQM 7712
Query: 3498 VLQALEPQV-DYLRNFTQ-GLVEDAPDG----SDASQLLHQAEVAQQEFLEVKQRVNSGC 3551
+ LE V + + TQ L++D D S L + E+ Q+++ E+ +++
Sbjct: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRR 7772
Query: 3552 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3611
+ +L F + +E+ L ++ ++ G I L I
Sbjct: 7773 QQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI---------------LIEEMIEK 7817
Query: 3612 LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVE 3671
LK D + A + +E K +L+ + ++ K + KA ++E LG+V
Sbjct: 7818 LKKDYQEEIA-----IAQEN-------KIQLQQMGERLAKASHESKA--SEIEYKLGKVN 7863
Query: 3672 DFYRKL--------KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQ 3723
D ++ L K L + A ++ + + T + I +LA ++ + +Q
Sbjct: 7864 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQ 7923
Query: 3724 MKLQQVNGLGQGLIQ-SAG------------KDCDVQGLEHDMEEI-------NARWNTL 3763
KL + L + + + S G DCD + + + I + RW +
Sbjct: 7924 RKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNI 7983
Query: 3764 NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQK 3823
+R +++E KF D WL +E A Y V K ++++ +
Sbjct: 7984 CAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE 8043
Query: 3824 LLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3883
QR + + ++++ + R+A+ + + RW L + + ++L
Sbjct: 8044 AFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRL 8103
Query: 3884 EDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHAT 3943
+ + ++F + I +L+ + +L N E +Q +I + KA +++I +
Sbjct: 8104 KHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE--CDVQAKIKQLKAFQQEISLNHN 8161
Query: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-F 4002
+ Q + G+ L + P + ++ E++D L+ E+ R R L RL
Sbjct: 8162 KIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL------IRLPL 8215
Query: 4003 GEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062
+DE ++ + E+ED S + D H + AD L + N ++ Q +++ +
Sbjct: 8216 PDDEHDLSDRELELED---SAALSDLHW---HDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
Query: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF--------QST 4114
+ + T V I + D D+ S+AL + ++ Q F
Sbjct: 8270 S--GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD 8327
Query: 4115 YEELTGWLREVEEELATSGGQSPTGEQI--------PQFQQRQKELKKEVMEHRLVLDTV 4166
+ L +R++ + L S Q E I P+ K K + E +D+V
Sbjct: 8328 HSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV 8387
Query: 4167 NEVSRALLE----LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 4222
+ L E L + + + ++++L+ + + +Q+ QQ+
Sbjct: 8388 KRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNS 8447
Query: 4223 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID-IIRHKDSMDELFSHRSE 4281
++ AW+ +T+ +L L + L D T +LQ++K + + H+ ++ + S
Sbjct: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
Query: 4282 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 4341
F ++ LQ++ + +++ + L E L+ A + F E L +E
Sbjct: 8508 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 8567
Query: 4342 ---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398
+ I + S +D E L+ +++ Q++ + E + + L + QL +N E
Sbjct: 8568 NIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEG 8625
Query: 4399 GEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQST 4435
+ +E EK N + +EV + L++ + S+
Sbjct: 8626 TDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 8664
Score = 199 bits (505), Expect = 9e-50
Identities = 435/2542 (17%), Positives = 998/2542 (39%), Gaps = 243/2542 (9%)
Query: 2913 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2961
+++LE K +L + S K+ E+V+ ++ +F+ EQ Q
Sbjct: 503 MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 562
Query: 2962 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 3021
+K+ + + +EAEN K E ++W + + + LEE S+ +
Sbjct: 563 LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 622
Query: 3022 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 3081
+ L+ WL + E MLN + + + QQH +N+A ++
Sbjct: 623 ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 669
Query: 3082 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRA 3141
+ + + ++++L +N +W EL ++ + +Q D+ +Y + + LS
Sbjct: 670 TCDE--MVSRDLKQQLLLLNGRWRELFMEV-KQYAQADEMDRMKKEYTDCVVTLSAFATE 726
Query: 3142 VGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 3201
++LS +S VK +++ +I + +D + K + + + LI ++ ++
Sbjct: 727 AHKKLSEPLEVSFM--NVKLLIQDLEDIEQRVPVMDAQYK----IITKTAHLITKESPQE 780
Query: 3202 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 3261
E K+ T + L++ L +QQ +EL + K
Sbjct: 781 EGKEMFAT----MSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 836
Query: 3262 ISAKLER-LQSQLQENEEFQKSL--NQHSGSYEVIVAEGES------LLLSVPPGEEKRT 3312
I LER QS ++ Q+ L ++ ++ +G L +V ++
Sbjct: 837 IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 896
Query: 3313 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 3372
LQ Q+ ++ ++ + KKT D + ++ + +K++ +L + + + E
Sbjct: 897 LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKG-- 954
Query: 3373 LDPVQLESSLLRSKAMLNEVEKR--RSLLEILNSAADILINSSEADEDGIRDEKAGINQN 3430
DP +L L R +++++R + L+ + DIL E ++ G+++ +++
Sbjct: 955 -DPEEL---LRRHTEFFSQLDQRVLNAFLKACDELTDIL---PEQEQQGLQEAVRKLHKQ 1007
Query: 3431 MDAVTEELQAKTGSLE---EMTQRLREFQESFKNIEKKV-----EGA----KHQLEIFDA 3478
+ E L+ E + L +E ++++ EG+ K F
Sbjct: 1008 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1067
Query: 3479 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ 3538
G K L+ + L +P V D P
Sbjct: 1068 KGPHHLCEKRLQLIEELCVKLPVRDP------------VRDTPG------------TCHV 1103
Query: 3539 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT---DSL 3595
E++ ++S + + + R E S ++ + +L G+ DT +
Sbjct: 1104 TLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV 1163
Query: 3596 QSQIEDVR---------LFLNKIHVLKLDIEASEAECRHMLEEEGTLD-----LLGLKRE 3641
+ +E++R L K + L +SE E + +E L L+ L E
Sbjct: 1164 KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSE 1223
Query: 3642 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3701
+E + G + + + LE + ++ + + + D E + L
Sbjct: 1224 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLL-------- 1275
Query: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3761
+ +QQ +K V + QQ G+G + G + ++ ++ + +
Sbjct: 1276 -LHHQQKTKRISAKKRDVQQQIAQAQQ----GEGGLPDRGHE--------ELRKLESTLD 1322
Query: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS-AEYKVVKAQIQ 3820
L + ++ ++Q L +F+ E ++ +L T ++++ S + + + ++++
Sbjct: 1323 GLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSELE 1380
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
+ K + + + L E I + +++ + Q +S++ + +L
Sbjct: 1381 QTKEFSKRTESIAVQAENLVKEASEIPLGPQ--NKQLLQQQAKSIKEQVKKLEDTLEEDI 1438
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
K +E + F E +S +++ EK+L E T ++ + QI + K ++IE+
Sbjct: 1439 KTMEMVKTKWDHFGSNFETLSVWITEKEKELNALE---TSSSAMDMQISQIKVTIQEIES 1495
Query: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC-CRKAALLDQALSNA 3999
+ + + QS + + E + K+ ++ E+++ C + +L LS
Sbjct: 1496 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH-LSQQ 1554
Query: 4000 RLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 4059
+ F E+ ++ ++E EDKL+ ++ +H+ L + + +++ AI
Sbjct: 1555 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL----ESLSSAIT 1610
Query: 4060 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELT 4119
A ++ + + ++ ++ +Y DI + + LE L +Q +EL+
Sbjct: 1611 AFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALE---NLLAHWQRLEKELS 1665
Query: 4120 GWLREVE--EELATSGGQSPTGEQIPQFQQRQ--KELKKEVMEHRLVLDTVNEVSRALLE 4175
+L +E E A+S + +++ + Q + L+ EV+ + ++ +L
Sbjct: 1666 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1725
Query: 4176 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 4235
+ + + + +E+++ + I +R++ + + + QQ+++ + W+
Sbjct: 1726 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---- 1781
Query: 4236 RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI---------FGTC 4286
+ L + QTT+++ + + + RHKD E+ S + E+ G+
Sbjct: 1782 -------KLFLSELQTTSEISIMD-HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL 1833
Query: 4287 GE-EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
G E +LQ K E Q +E S + R L + +F +++ LS + + R
Sbjct: 1834 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----LAEFLQSHASLSGILRQLRQ 1889
Query: 4346 LIAQLPSPAIDHEQLRQQQ-EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 4404
+ S + L ++ + Q +++ +D +L L E
Sbjct: 1890 TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY--HLKIGSSEQRTS 1947
Query: 4405 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464
A+ + +++ EA + + F D+ E +L+++E++ R L
Sbjct: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2007
Query: 4465 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKEIQDKLD 4523
+++ + EL + LK + +++ A KD+A A E+ +++
Sbjct: 2008 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREIN 2061
Query: 4524 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4583
++ W+D K E + + +++L ++ +A+ +++ ++ + D
Sbjct: 2062 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI-VTRTTIKDQED 2120
Query: 4584 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE---VRKSIDEMNNAWEN 4640
+K ET K + + ++L+ G L+ + + V+ ++ + W +
Sbjct: 2121 LKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLD 2180
Query: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE- 4699
+++ +E +++L ++ T + W +N V P + +++ + + L
Sbjct: 2181 VSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCV------PQMAENISNLDNHLRAE 2234
Query: 4700 --MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4757
+KEF+ EV + + +E+L+ K D + E +L+ + +L +K+ H
Sbjct: 2235 ELLKEFESEVKNKALRLEELH-------SKVNDLKELTKNLETPPDLQFIEADLMQKLEH 2287
Query: 4758 RQHKLEGALLALGQF-------QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
+ E A L F + + ++ +W T EE L ++ L K
Sbjct: 2288 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-----MNCAQNETCEALKKV 2342
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
++ ++ + Q+ + + + N L + SL + + + E+V Q + +
Sbjct: 2343 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2402
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
LQ +L+ + F +++F ++ S G + +L + + +
Sbjct: 2403 LQESLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2460
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATE 4990
+ + +G+ L + S ++ + +++ + + K L++ +
Sbjct: 2461 SKLDAVTQEGQ-TLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGS 2519
Query: 4991 FQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV--FANEVNAHRDQIIELDQ 5048
F++ ++ W+ E+ N + + + E HKV F E+ A R+ + +L Q
Sbjct: 2520 FEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2579
Query: 5049 TGNQLKFLSQK-----QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103
G + LS++ Q+ L LL S Q+ +++ + E+ RS A + + EA
Sbjct: 2580 RG---QLLSEEGHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEA 2632
Query: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG-RAL 5162
+ + W++ + L D ++ +LS+ ++ G + + I G +AL
Sbjct: 2633 LQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL 2692
Query: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
+ E + + L +++ W + SV Q LE + +++ L W+
Sbjct: 2693 RSSN--KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2750
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 5282
V+ ++ L L+D + E T + L REL E + D++
Sbjct: 2751 SVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFK 2810
Query: 5283 VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL 5342
Q +EL T+++ + ++ K ++E+ +K ++ D VH +WL A++ L +
Sbjct: 2811 DTAQ-EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2869
Query: 5343 PDDTEALQSLIDTHKEFMKKVE 5364
D+ A Q + KE + E
Sbjct: 2870 SGDSSATQKKLSKIKELIDSRE 2891
Score = 187 bits (475), Expect = 3e-46
Identities = 548/3186 (17%), Positives = 1207/3186 (37%), Gaps = 458/3186 (14%)
Query: 1837 LQDLLCQAKVLERELKDLTTLVS---QELECVNQIIISQPQEVPAQLLK--ALEKDAKNL 1891
+Q + Q + E+E+K L L+ +E+E + S QE+ AQ+ + L + K
Sbjct: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIED-KPVATSNIQELQAQISRHEELAQKIKGY 5791
Query: 1892 QKSLSSVSDTWNSRLLHFQNA---VEIEKTKVLNQHTQ-LEGRLQD--------LRAWVG 1939
Q+ ++S++ + ++A + + + + L + T+ L+G L + G
Sbjct: 5792 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 5851
Query: 1940 NKNLILN-------SKGSNSEID----------VDSLNLCLQQYEDLKQPMAERKAQLDA 1982
+ +L+ +G+NSEI V + + + Q Q ++ + Q DA
Sbjct: 5852 RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDA 5911
Query: 1983 LAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA 2042
S+ + P L +LQRS++ + + + Q
Sbjct: 5912 AKIHPSTSASQEFYE--PGLEPSATAKLGDLQRSWETLKNVISEK------------QRT 5957
Query: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAG--HQGRTTQQDLSALQKNQSDLKDLQDD 2100
L + L++QQ L+ + + + E L+ GR+ + ++ Q ++ LQD+
Sbjct: 5958 LYEALERQQKY-QDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 6016
Query: 2101 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 2160
I +S A E + E+ + P E AL+ L E+ ++ + ++ LE
Sbjct: 6017 INELQSSLA------EELVSES-CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 6069
Query: 2161 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 2220
E + L+++ ++ + L + + D L W+ S
Sbjct: 6070 EKLNDQLEEQRQE----QALQRYRCEADELDSWLLST----------------------- 6102
Query: 2221 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL- 2279
K LDT ++ E +D + ++M ++ L+ +Q + ++ L H NL
Sbjct: 6103 KATLDTA-----LSPPKEPMDMEAQLMDCQNM-LVEIEQKVVALSE-----LSVHNENLL 6151
Query: 2280 ------TPEEQQMLQQKLGELKEQY-STSLAQSEAELKQVQTLQDELQKFLQ----DHKE 2328
T +E + L KL LK A + +L T Q++ + +
Sbjct: 6152 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 6211
Query: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
+ WL ++ + S L++Q +++ K LR V G+++L
Sbjct: 6212 VQEWLAQARTTWTQQRQ---------SSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6262
Query: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
++ + + E +++ +L E+ +A + M HQ ++
Sbjct: 6263 SAAETSGDAGEKPDVLSQELGMEGEKSSA--------EDQMRMKWESLHQEFSTK----- 6309
Query: 2449 WMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG 2508
+KLL + + E + QV + ++ + +G
Sbjct: 6310 ---------QKLLQNVL-------------------EQEQEQVLYSRPNRLLSGVPLYKG 6341
Query: 2509 E-PAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567
+ P D V D + F+ +S ++ +++I Q + + + + + +VE
Sbjct: 6342 DVPTQDKSAVTSLLDGLNQAFEEVS---SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVE 6398
Query: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTR-FMETADST----- 2621
+ L ++L + L L +DI ++ + + ++ F E D+
Sbjct: 6399 ERLF--VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIED 6456
Query: 2622 TAAVLQGKLAEVSQRFEQLCLQQQEK-------ESSLKKLLPQAEMFEH--LSGKLQQFM 2672
T L G+L+ + Q C Q +E+ ++ LK L ++ L F
Sbjct: 6457 TLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFE 6516
Query: 2673 ENKSRMLASGNQPDQDITHFFQQIQELN-----LEMED-QQENLDTLEHLVTEL------ 2720
+ + + + Q + + F I EL L++E + L L+ + EL
Sbjct: 6517 QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGS 6576
Query: 2721 --SSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK-DASSCQEQLDEFRKLVRTFQKW 2777
S L L +R +D +L +T +E+ D +E ++L+ +++
Sbjct: 6577 RRSGLNQNLTLKSQYERAL---QDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY 6633
Query: 2778 LKETEGSIPPTET---SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME 2834
+ E + TET + + ++K+ + L+ A +++ + +G LE ++
Sbjct: 6634 FQGLESHMILTETLFRKIISFAVQKETQFHTELM---AQASAVLKRAHKRGVELEYILET 6690
Query: 2835 ITAPDSQGK--------TGSILPSVG-------SSVGSVNGY-HTCKDLTEIQCDM---- 2874
+ D + S +PSVG + + Y H L E Q +
Sbjct: 6691 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVL 6750
Query: 2875 ------------SDVNLKYEKLGGVLHERQESLQAILNRMEEVHK-------EANSVLQW 2915
SD+ + +LG + L+R+E + K E+ ++ W
Sbjct: 6751 DDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 6810
Query: 2916 LESKEEVLK--SMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTY 2973
L+S ++ L+ + +++ P + E V+ + F E++ S V LL
Sbjct: 6811 LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL- 6869
Query: 2974 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM---- 3029
+ + ++S+W A Q +L + + A S++ W+
Sbjct: 6870 -KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMEN 6928
Query: 3030 ----EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGD 3085
+++ + +G +I + + ++ K+ L ++Q + + D
Sbjct: 6929 VIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD 6988
Query: 3086 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQR 3145
+ ++L ++N+ W L + + ++ + ++Y+ +Q L +R
Sbjct: 6989 ----KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 7044
Query: 3146 LSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY-LKDELK 3204
L Q I Q +V+ L++ ++ ++ + EV++ + + L+++ ++ + +
Sbjct: 7045 LKQQHRIGDQA-SVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSIVM 7101
Query: 3205 KRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 3264
L + L+ + L++ L + FD++ ++L + + ++ ++
Sbjct: 7102 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTG 7161
Query: 3265 KLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV-PPGEEKRTLQNQLVELKNH 3323
LE +Q Q+ + Q L + S + + LL PP E TL N L E+
Sbjct: 7162 SLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE--TLTNTLKEVNMR 7219
Query: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
W L ++ A++ K +Q Q+Y+ + + ++ + + +EL +
Sbjct: 7220 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADD-- 7277
Query: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADED-----------GIRDEKAGINQNMD 3432
+ ++ LL+ L + D L E E I+ ++ ++Q++
Sbjct: 7278 ---EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLC 7334
Query: 3433 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN--KNLE 3490
A+ + L + SL+ F +S + +E + A+ L+ D S S + +E
Sbjct: 7335 ALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERME 7394
Query: 3491 KLRAQQEVLQALEPQVDYL-----------------RNFTQGLVEDAPDGSDASQLLHQA 3533
+L+ Q ++ P +D L +N + + ++ L
Sbjct: 7395 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSF 7454
Query: 3534 EVAQQEFLEVKQRVNSGCVMMENKL--EGIGQFHC-----RVREMFSQLADLDDELDGMG 3586
+ Q FLE + V E KL E G + R E+F A++ +
Sbjct: 7455 LLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQ--AEMFSRQQILH 7512
Query: 3587 AIGRDTDSL--QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEA 3644
+I D L Q Q++D F K+ +L + R + G +D
Sbjct: 7513 SIIIDGQRLLEQGQVDDRDEFNLKLTLLS---NQWQGVIRRAQQRRGIID---------- 7559
Query: 3645 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEII 3704
++ + + R+ +L VE Y + GL ++A L V + ++
Sbjct: 7560 -----SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVF 7614
Query: 3705 NQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764
+Q + + + G+ L+ SA + L+ ++ EI +W + +
Sbjct: 7615 LRQQGSYILTVEA---------------GKQLLLSADSGAEA-ALQAELAEIQEKWKSAS 7658
Query: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824
++ ++ +L L K + + L L ++ ++ P ++ + A+ K
Sbjct: 7659 MRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD--HHEELHAEQMRCKE 7716
Query: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
L+ + + L ++ D + ++E L+ +W EL + + R++Q+
Sbjct: 7717 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 7776
Query: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR-HKALEEDIENHAT 3943
+ L F E + + ++L+ E K++ + + I++ I + K +E+I
Sbjct: 7777 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQE 7831
Query: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 4003
+ Q ++G+ L+ + ++ + K+ + R+ + D + L + L +
Sbjct: 7832 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 7891
Query: 4004 EDEVEVLNWLAEVEDKLSSVFVKDF-KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062
++ + WLA +E +L+ V D + + R+ + L +I V + +
Sbjct: 7892 KNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE 7951
Query: 4063 ALLKQ----TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEEL 4118
LL T E IQ+ + R+ +I S + +E+ +L KF Y
Sbjct: 7952 VLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRF 8011
Query: 4119 TGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
WL+ E A + ++ + +++V E L+ +N+ R L
Sbjct: 8012 EDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR 8071
Query: 4179 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 4238
+ L ++V + N+++ + + + + I + +++E A D+ L W+ E +L
Sbjct: 8072 TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL 8131
Query: 4239 ------------------------MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
++L ++EQ + ++K+ +D ++ +DE
Sbjct: 8132 TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 8191
Query: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
L + E+FG K +++ +++ S+R LE + L + W
Sbjct: 8192 LRRYCQEVFGRVERYHKKLIRLPLPD--DEHDL-----SDRELELEDSAALSDLHWHDRS 8244
Query: 4335 E---LSPWIEETRALIAQLP---------SPA-IDHEQLRQQQEE--MRQLRESIAEHKP 4379
LSP +L P +PA +D L + R L +++ P
Sbjct: 8245 ADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALP 8304
Query: 4380 HIDKLLKIGPQLKELNPEEGEMVEEKYQKA----ENMYAQIKEEVRQRALALDEAVSQST 4435
D EEG+ ++ Y + ++ ++ ++RQ ALD++ Q
Sbjct: 8305 SED--------------EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQ 8350
Query: 4436 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEAL 4495
Q T + S+ P + + + + S+ +++L+ L
Sbjct: 8351 Q-------------TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE---HKL 8394
Query: 4496 KRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWY 4555
K E L G + + D+ WE ++A+A +E++ L+ ++F
Sbjct: 8395 KEEEESLPGFVNLHSTETQTAGVIDR-------WELLQAQALSKELRMKQNLQKWQQFNS 8447
Query: 4556 DMAALLTTIKDTQDIVHDLESPGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRILGA 4613
D+ ++ + DT++ + L+ + I I+ Q++ + +++ D + I +
Sbjct: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
Query: 4614 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673
+ A E +++ + +MN W+ + +E L+DA+ + + + L
Sbjct: 8508 EFTQA-DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
Query: 4674 DNTVIKLCTMPPVGTDLNT--VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDE 4731
+N + + P+ ++L+ ++D ++ + K E+ + Q+ + L +L A +
Sbjct: 8567 ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA-EG 8625
Query: 4732 TDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD 4791
TD +E + + + + L ++++ +LE L + ++L SW + E LD
Sbjct: 8626 TDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE--LD 8679
Query: 4792 AQRPIS 4797
+S
Sbjct: 8680 TSGSVS 8685
Score = 128 bits (322), Expect = 1e-28
Identities = 348/1922 (18%), Positives = 743/1922 (38%), Gaps = 191/1922 (9%)
Query: 3648 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3706
Q + ER EL L ++E K + L+ A E++ W++ E + Q
Sbjct: 481 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 538
Query: 3707 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764
L ++ F + + ++ Q + + +++ G + + + M E A+W L+
Sbjct: 539 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 598
Query: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824
+V + L+E + + ++ + + L +WL D E+++ + ++ +
Sbjct: 599 VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDF---------FRN 649
Query: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
L + A D G + ++ + + QL L RW EL + + Q +
Sbjct: 650 LPHWIQQHTAMND----AGNFLIETCDEMVSRDLKQQLLLLNGRWRELFME-VKQYAQAD 704
Query: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944
++ + K++ + +S F + KKL+ V K+ Q + EDIE
Sbjct: 705 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 758
Query: 3945 VHQAVKIGQSLSSL---TSPAEQG-VLSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3998
+ KI + L SP E+G + + L+ + +++++ C L + Q L
Sbjct: 759 MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 816
Query: 3999 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 4057
+ + L ++ +++ +V ++ + L +Q H + LA E N KK +
Sbjct: 817 LEELEKQMTSFYDSLGKI-NEIITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 872
Query: 4058 IKNGQALLKQTTGEEVL------LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 4111
K Q++ K T VL +Q ++ I + + + + +E +L KF
Sbjct: 873 EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 932
Query: 4112 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 4171
+ + EL LR +E L G + +R E ++ + VL+ +
Sbjct: 933 EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 983
Query: 4172 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 4231
L +++P + ++GL + V ++Q+K D G+ + L
Sbjct: 984 ELTDILPEQEQQGLQEAVRKLHKQWK---DLQGEAPYHL---------------LHLKID 1025
Query: 4232 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 4291
E R L ++ R E D+ T +L Q+ I H+ + H C E++
Sbjct: 1026 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1078
Query: 4292 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 4337
+++E L + E + ++S Y +L + + E S
Sbjct: 1079 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS-TYRKLMEDPDKWKDYTSRFSEFS 1137
Query: 4338 PWIEETRALIAQLPSPAID---HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 4394
WI + + AID H ++++ EE+R E + LK+ ++
Sbjct: 1138 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS- 1196
Query: 4395 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 4454
E + QK + A++ + L E + + E + +LE L
Sbjct: 1197 --------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1248
Query: 4455 SSRLRMPPLIPAEVDKI--RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512
S + + + +KI E + + + + ++ A KR ++ I ++Q +
Sbjct: 1249 ISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
Query: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
L + ++L ++ + ++ E +E + L E+F T K+T +V
Sbjct: 1306 LPDRG-HEELRKLESTLDGLERSRERQERRIQVTLRKWERF--------ETNKET--VVR 1354
Query: 4573 DLESPGI--DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4630
L G + + +E+ + E+T + E I + +L+ E K
Sbjct: 1355 YLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ 1414
Query: 4631 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-------- 4682
+ + K+ KE+++KLED ++ ++ + ++ +D + L
Sbjct: 1415 L------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKE 1468
Query: 4683 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK-KATDETDRDIIREPL 4741
+ + T + + Q++++K E+ + + L + + + T E+ R I+ L
Sbjct: 1469 LNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKL 1526
Query: 4742 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4801
T+++ E L E + + G L +F+ L ++ ++ E+ L I
Sbjct: 1527 TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
Query: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861
L +H L + + + + + + +++ + S A+ Q +E +L
Sbjct: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDIL 1640
Query: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE-QLDTHM 4920
++ +ER+ L++ L Q E+ FL L R E++ S+ + E +L
Sbjct: 1641 RRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1700
Query: 4921 ELYSQLKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4978
L +++ ++ Y++LL + + S+DD + + L+++W + + +R
Sbjct: 1701 ALQNEVVSQASFYSKLLQLKESLFSVASKDDV---KMMKLHLEQLDERWRDLPQIINKRI 1757
Query: 4979 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 5038
+ L+ + +F L F W+ L L S S++ + V + HK A EV +
Sbjct: 1758 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV--ALTRHKDHAAEVES 1815
Query: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098
+ ++ L +L L + +D+ L++ +E+ Q +ER R L A
Sbjct: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ-VVER-RQL--ALSHLA 1871
Query: 5099 QFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157
+F ++ L L +++ ++ N+ D I+ L+ + K L D +
Sbjct: 1872 EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILS 1931
Query: 5158 TGR-ALKEKTLLPEDSQK--LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 5214
+ LK + S + D GEV ++ + G +Q + + + F D
Sbjct: 1932 KAQYHLKIGSSEQRTSCRATADQLCGEV-ERIQNLLG---TKQSEADALAVLKKAFQDQK 1987
Query: 5215 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 5274
+ L+ + +E + +++ + + + EL + LK +++ +
Sbjct: 1988 EELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ 2047
Query: 5275 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 5334
V ++ L WD +L Q + + +++ + + L A
Sbjct: 2048 KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2107
Query: 5335 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA---VCHPDCITT 5391
+ R + D E L+ H+ K+ K+ D+++ + G+ +L+ H +
Sbjct: 2108 VIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL 2166
Query: 5392 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 5451
+K + ++ +V +++ RL +LS +E+ W + + E
Sbjct: 2167 VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW----SNNCVPQMAE 2222
Query: 5452 PIPQNID---RVKALIAEHQT-------FMEEMTRKQPDVDRVTKTYKRKNIE-PTHAPF 5500
I N+D R + L+ E ++ +EE+ K D+ +T KN+E P F
Sbjct: 2223 NI-SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELT-----KNLETPPDLQF 2276
Query: 5501 IE 5502
IE
Sbjct: 2277 IE 2278
Score = 121 bits (303), Expect = 2e-26
Identities = 359/1924 (18%), Positives = 763/1924 (39%), Gaps = 281/1924 (14%)
Query: 1809 KLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLEREL--KDLTTLVSQELECVN 1866
+++S++SL+ N+ + + + + + L + K + ++ K LT ++ VN
Sbjct: 6918 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT------VDFVN 6971
Query: 1867 QIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK-VLNQHT 1925
Q ++ ++ +Q +++ D + + L +++ +W ++L +I+ + +L +
Sbjct: 6972 QSVL----QISSQDVESKRSDKTDFAEQLGAMNKSW--QILQGLVTEKIQLLEGLLESWS 7025
Query: 1926 QLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAF 1985
+ E +Q L+ W + L K + D S+ L+ +DL+ + ++ +++ +
Sbjct: 7026 EYENNVQCLKTWFETQEKRL--KQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7083
Query: 1986 DIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK 2045
+ I +D+S ++ L EL QT A +D + G L+ L+K
Sbjct: 7084 NGLALIQNKKEDVSSI----VMSTLRELG--------QTWANLDHMVGQLK-----ILLK 7126
Query: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRA 2105
++ Q ++ + + S++ +A +L+ + R L A+Q +L++LQDD++ +
Sbjct: 7127 SVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQVDNLQNLQDDLEKQE 7184
Query: 2106 TSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTS 2165
S ++E P L L + ++ L EE Q + +A+
Sbjct: 7185 RSLQKFGSITNQLLKE----CHPPVTETLTNTLKEVNMRWNNLLEEI-AEQLQSSKALLQ 7239
Query: 2166 ALQQETEKSK-AAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGAL 2224
Q+ + SK A + + + + + LL T+ + ++ T + L KG
Sbjct: 7240 LWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL-----KGLG 7294
Query: 2225 DTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQ 2284
D +++ E+L +Q + A A QS Q L QH L EQ
Sbjct: 7295 TVKDSLFFLHELGEQLKQQVDASAAS-------------AIQSDQLSLSQH---LCALEQ 7338
Query: 2285 QMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMH 2344
+ +Q+ TSL Q L + + F + + E+W+ +E+ L+
Sbjct: 7339 ALCKQQ---------TSL--------QAGVL--DYETFAKSLEALEAWIVEAEEILQGQD 7379
Query: 2345 KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLV 2404
SS L ++ +R + L+F +++ E ++ EI
Sbjct: 7380 PSHSSD--LSTIQERMEELKGQM------LKFSSMAPDLDRLNELGYRLPLNDKEI---- 7427
Query: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDT 2464
++++ ++ + S+ T S L L Q+ F + + WM+ +KL +
Sbjct: 7428 -KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAVEI 7483
Query: 2465 VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSI 2524
+ +L++Q A E + Q+ L + D + + D R ++
Sbjct: 7484 SGNYQHLLEQQRAHELFQAEMFSRQQI----LHSIIIDGQRLLEQGQVDDRDEFNLKLTL 7539
Query: 2525 LSH-FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2583
LS+ +Q + +R ++ I Q Q +E E L + + EV +S L S I
Sbjct: 7540 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY----LPMSGLGSVPI 7595
Query: 2584 --QEA--LATNMKLKQDI-ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE 2638
Q+A L ++ K+ + RQ+ S T E + + +ADS A LQ +LAE+ ++++
Sbjct: 7596 PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWK 7655
Query: 2639 Q--LCLQQQEK---------ESSLKKLLPQAEMFEHLSGKLQQFMENKSRML-------- 2679
+ L++Q+K E K + E KL Q + + L
Sbjct: 7656 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCK 7715
Query: 2680 ----ASGNQPDQDITHFF------------QQIQELNLEMEDQQENLDTLEH-LVTELSS 2722
A G+ D D+T I LN +E Q + L H L
Sbjct: 7716 ELENAVGSWTD-DLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQ 7774
Query: 2723 CGFAL-----------DLCQH----------------QDRVQNLRKDFTELQKTVKEREK 2755
G L +LC+ ++ ++ L+KD+ E +E +
Sbjct: 7775 IGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKI 7834
Query: 2756 DASSCQEQLDEFR----------KLVRTFQKW-------------LKETEGSIPPTETSM 2792
E+L + KL + +W LKET ++ + +M
Sbjct: 7835 QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 7894
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLE-NLIMEITAPDSQGKTG--SILP 2849
S+ L + H++S L +K + + N + + N E+ + TG S+L
Sbjct: 7895 SS--LRTWLAHIESEL----AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLN 7948
Query: 2850 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909
+ + T + IQ +++ ++ + + ER+ ++ ++ +
Sbjct: 7949 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 8008
Query: 2910 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2969
+ WL+S E + SS K + + +AF ++ + +++ + + L
Sbjct: 8009 SRFEDWLKSSERT--AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 8066
Query: 2970 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 3029
+ A + K++ E N RW+ + + R+L+ F+ A + WL
Sbjct: 8067 -ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 8125
Query: 3030 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPG 3084
E +L + N+ + + VQ +K+ +A +Q+ H ++ + AQG
Sbjct: 8126 EMDLQL---------TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 8176
Query: 3085 DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144
L + +++EL + + E+ ++ ++ + + ++ ++L + A
Sbjct: 8177 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 8236
Query: 3145 RL-----SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYL 3199
L S S +S QP + L +RS+ ++ D + + Y
Sbjct: 8237 DLHWHDRSADSLLSPQPSS-NLSLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY- 8289
Query: 3200 KDELKKRLETV---ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW---LDDK- 3252
+L + LE+ ALP + E+ D+ L+ A+ + + ++R LDD
Sbjct: 8290 --DLSRDLESAMSRALPSED-EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 8346
Query: 3253 -QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL---SVPPGE 3308
Q QQ +N I +K + + K L + S S + + L S+P
Sbjct: 8347 FQIQQTENI-IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 8405
Query: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368
+ + Q + + WE L + ++ R+K +QK Q++ + + W+ D + ++ +
Sbjct: 8406 NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8465
Query: 3369 LR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKA 3425
L+ ++ D +E + + K + V+ R++++ +N + + + ++D +
Sbjct: 8466 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLS 8525
Query: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEIFDA-LGS 3481
+N D V L+ G L++ + + F E + + ++ K+++ D+ L +
Sbjct: 8526 QMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA 8585
Query: 3482 QACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL 3541
+ + + + ++ + E+L++ + +V L++ + L+ +A +G+D + + V
Sbjct: 8586 EILQDHHKQLMQIKHELLES-QLRVASLQDMSCQLLVNA-EGTDCLEAKEKVHVIGNRLK 8643
Query: 3542 EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD-----DELDGMGAI----GRDT 3592
+ + V+ +E L ++ S DL DELD G++ GR T
Sbjct: 8644 LLLKEVSRHIKELEKLL-----------DVSSSQQDLSSWSSADELDTSGSVSPTSGRST 8692
Query: 3593 DSLQ 3596
+ Q
Sbjct: 8693 PNRQ 8696
Score = 49.7 bits (117), Expect = 9e-05
Identities = 113/608 (18%), Positives = 233/608 (38%), Gaps = 90/608 (14%)
Query: 4982 EEALNLATEFQNSLQEFIN-----------WLTLAEQSLNIASPPSLILNTVLSQIEEHK 5030
+E L F NS+Q F W+ E+ L A ++ + + + + K
Sbjct: 296 DEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ---MVESNLQDKYQSFK 352
Query: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
F + R QI L Q ++ LS Q +V + W++V R + L
Sbjct: 353 HFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALV---------KQSWDRVTSRLFDWHIQL 403
Query: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK----IKLQLSKHKEFQKTLG 5146
D K + WL AE L E+ + ++ I+ +L +HK+ +
Sbjct: 404 D------KSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD 457
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 5206
+ + RT R++ + P+ L ++ +++ V S E L
Sbjct: 458 AHKRAFHEIYRT-RSVNGIPVPPDQ-------LEDMAERFHFVSSTS--------ELHLM 501
Query: 5207 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF---QKELGKRTGTVQ 5263
+F++ L+ L E +L +G + V L+ + F K + T Q
Sbjct: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 561
Query: 5264 VLKRSGRELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 5321
+LK++ + + S ++ V + E + +W + S +S LE+ + + + +T
Sbjct: 562 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 621
Query: 5322 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVE---EKRVDVNSAVAMGE 5378
V L WL +AE+ L + +E + K+F + + ++ +N A G
Sbjct: 622 VASLQAWLEDAEKML-------NQSE------NAKKDFFRNLPHWIQQHTAMNDA---GN 665
Query: 5379 VILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI 5438
++ C +K + ++ R+ E+ KQ+ Q E+ + + + +
Sbjct: 666 FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTL 720
Query: 5439 QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHA 5498
T ++ EP+ + VK LI + +E++ ++ P +D K + H
Sbjct: 721 SAFATEAHKKLSEPLEVSFMNVKLLIQD----LEDIEQRVPVMDAQYKIITK----TAHL 772
Query: 5499 PFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5558
E + G++ + + + E +P + + QQ+ + E ++++
Sbjct: 773 ITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYES----QQLLIPLEELEKQMTSFY 828
Query: 5559 DRLEELKE 5566
D L ++ E
Sbjct: 829 DSLGKINE 836
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 328 bits (840), Expect = 1e-88
Identities = 685/3702 (18%), Positives = 1442/3702 (38%), Gaps = 512/3702 (13%)
Query: 2036 QQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLK 2095
+Q EQ +L + + +Q+ E +C + + +++ Q + ++ L A +K +
Sbjct: 4693 RQTEQRV---SLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK---- 4745
Query: 2096 DLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVA 2155
+ + V+K + +E+ L P R ++ + + + L
Sbjct: 4746 -MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGET 4804
Query: 2156 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 2215
E E + ++ +TE S++ LDW+ V + +LS
Sbjct: 4805 VTECESRMVQSIDFQTEMSRS--------------LDWLRRVKA-------------ELS 4837
Query: 2216 G-ASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 2274
G L+ D + + E++ +M A + +++ F A + A L+
Sbjct: 4838 GPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHK---EKEKFTKAKELISADLE- 4893
Query: 2275 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLE 2334
H+L +L EL +L +A L ++ + + Q++ Q + WLE
Sbjct: 4894 --HSLA---------ELSELDGDIQEALRTRQATLTEIYS---QCQRYYQVFQAANDWLE 4939
Query: 2335 RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEG 2394
+++ L+ G +L FS + H L+ +S
Sbjct: 4940 DAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN------------LEELHSLVAT 4987
Query: 2395 KEPSEIGNLVKDKLK-DATERYTALHSKCTRL----GSHLNML---LGQYHQFQNSADSL 2446
+P L+K K D ++ +L + R+ G+ +++L Q+H +Q + +
Sbjct: 4988 LDP-----LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREE- 5041
Query: 2447 QAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
V +L++DT + +++ + +E+L+EH+ V + I+ +
Sbjct: 5042 ----------VIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5091
Query: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYS--------LAERSSLLQKAIAQSQSVQESLES 2558
E + + + + + + LS + + ++ +L+ A+ + ++
Sbjct: 5092 EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKK 5151
Query: 2559 LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETA 2618
+ I +++ L G S + L + ++ +Q+S+L R+ ++
Sbjct: 5152 ATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDG 5211
Query: 2619 DSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQA----EMFEHLSGKLQQFMEN 2674
+ T + E++ + CL QEK + KL+ Q EM E ++ +++
Sbjct: 5212 AAPTPGEEPPLMQEITA-MQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5270
Query: 2675 KSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEH------------LVTELSS 2722
L + P +I +++Q L E + ++N++ + L +ELS
Sbjct: 5271 TKEYLGN---PTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL 5327
Query: 2723 --CGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKE 2780
ALDL K ++Q +KE E+ ++ QE + +KL + L +
Sbjct: 5328 QLAEVALDL-----------KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTK 5376
Query: 2781 TEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDS 2840
+ T+ + AK +K + G ++ N K L+ + + +
Sbjct: 5377 LKAK---TDNVVQAKTDQKVL-------------GEELDGCNSKLMELDAAVQKFL--EQ 5418
Query: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900
G+ G L +G + H + + + + +S +N + L E E L+ IL
Sbjct: 5419 NGQLGKPL---AKKIGKLTELHQ-QTIRQAENRLSKLN----QAASHLEEYNEMLELILK 5470
Query: 2901 RMEEVHKEANSVLQW----------------LESKEEVLKSMDAMSSPTKTETVKAQAES 2944
+E+ A+ + W LE +E+ ++AM+ + T E
Sbjct: 5471 WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEK 5530
Query: 2945 NKAFLAELEQNSPKI-QKVKEALAGLLVTYPNSQEAE-NWKKIQEELNSRWERATEVTVA 3002
+AEL + + ++ Q +K L L + ++ E KK+Q L T V
Sbjct: 5531 MSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVG 5590
Query: 3003 RQRQLEESASHLACFQAAESQLRPWLMEKELMMG-------VLGPLSIDPNMLNAQKQQ- 3054
R L+E SH + L+P + +L V+ L + L Q++
Sbjct: 5591 RL-SLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEAS 5649
Query: 3055 ------------VQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ 3102
+Q + ++E Q+ + L + +G D ++TS +Q ELQ+
Sbjct: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ-ELQAQIS 5708
Query: 3103 KWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQ 3162
+ EL K+ YQE + L+ K + + + + + T E V+
Sbjct: 5709 RHEELAQKIKG--------------YQEQIASLNSKCKMLTMKAKHATMLLTVTE-VEGL 5753
Query: 3163 LEETSEIRSDL--------EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE------ 3208
E T ++ +L + TL ++ GE+ E+
Sbjct: 5754 AEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSP 5813
Query: 3209 ------TVALPLQGLEDLAADRIN----RLQAALASTQQFQQ----------MFDELRTW 3248
+V + + L+A+R+ ++ + +++Q+F + + D R+W
Sbjct: 5814 VANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSW 5873
Query: 3249 -----------------LDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYE 3291
L+ +Q Q IS K+E ++ +L E+ E +S ++
Sbjct: 5874 ETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQ 5933
Query: 3292 VIVAE---------------GESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKKTADR 3334
++ E E L+ + E+ LQ+ L L + K + +
Sbjct: 5934 ALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGK 5993
Query: 3335 QSRLKDCM----------QKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLDPVQLESSLL 3383
+ L++ + Q Q+Y+ ++L W+ KA + + L +P+ +E+ L+
Sbjct: 5994 RQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLM 6053
Query: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG 3443
+ ML E+E++ L L S +E+ + + KA + + +L+ G
Sbjct: 6054 DCQNMLVEIEQKVVALSEL----------SVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6103
Query: 3444 SLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQ--------ACSNKNLEKLRAQ 3495
SL E+ + L + Q + + ++ E + L + G Q + + L+ Q
Sbjct: 6104 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQ 6163
Query: 3496 QEVLQALEPQVDYLRNFTQGLVE------DAPDGSDASQLLHQAEVAQQEFLEVKQRVNS 3549
+E+ Q L Q LR+ E A DA + + +V QE L ++ +S
Sbjct: 6164 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE---KPDVLSQE-LGMEGEKSS 6219
Query: 3550 GCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKI 3609
M K E + Q +++ + + + E Q L+ +
Sbjct: 6220 AEDQMRMKWESLHQEFSTKQKLLQNVLEQEQE--------------QVLYSRPNRLLSGV 6265
Query: 3610 HVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGR 3669
+ K D+ + L L GL + E ++ Q G A+++ + L
Sbjct: 6266 PLYKGDVPTQDKSAVTSL-------LDGLNQAFEEVSSQSGG------AKRQSIHLEQKL 6312
Query: 3670 VEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3729
+ L+D A AL TE + NQ++ + + + ++ +
Sbjct: 6313 YDGVSATSTWLDDVEERLFVATALL-PEETETCLFNQEIL------AKDIKEMSEEMDKN 6365
Query: 3730 NGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
L G + DV +E + + R + L+ V QR Q++E L FQ+ L+
Sbjct: 6366 KNLFSQAFPENGDNRDV--IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLK 6423
Query: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
L + LAD + +I QK + + V QI+ + + L + A + L+ G +
Sbjct: 6424 VLFTSLADNKYIIL-QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDK---- 6478
Query: 3850 AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEK 3909
L + +L L+ + EL+ +R+ L L L Q+ + ++D L ++
Sbjct: 6479 --LQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6536
Query: 3910 KLANSEPVGTQTAK-IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
K+A + + + + IQQ + +HK + +E+H + + S E +
Sbjct: 6537 KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFR---KIISFAVQKETQFHT 6593
Query: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
E L A+ S + R ++ L+ L ED+ E+ L VE + SV + +
Sbjct: 6594 E----LMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6649
Query: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYA 4088
+D L + + L + + + Q + +G+ LL + + ++ +L+ + +
Sbjct: 6650 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWL 6706
Query: 4089 DITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ------- 4141
T SK L LE + T++QS +L WL+ ++ L QS T Q
Sbjct: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
Query: 4142 -IPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS---DANEQYK 4197
+ F + KE+ + VL T N++ R L ++ R L ++ S D
Sbjct: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-LKKVDTATLRSELSRIDSQWTDLLTNIP 6825
Query: 4198 LVSDTIGQ-RVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-- 4254
V + + Q ++D++ + A ++W++ + I+ ++D
Sbjct: 6826 AVQEKLHQLQMDKLPS--------RHAISEVMSWIS------LMENVIQKDEDNIKNSIG 6871
Query: 4255 -------LQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQ---KTVLQEKTESLIQQ 4304
LQ K F IDI + ++D + +I E + KT E+ ++ +
Sbjct: 6872 YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS 6931
Query: 4305 YEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQ 4364
++ + L +E+ LE +++ + L W E + Q D ++
Sbjct: 6932 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNAL 6990
Query: 4365 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE-GEMVEEKYQKAENMYAQIKEEVRQR 4423
++ + L + I + ++K+ + G L + E+ +V ++ +A + V Q
Sbjct: 6991 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7050
Query: 4424 ALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATV 4483
+ L + Q + DKI L SR R L+ ++ ++ + + ++
Sbjct: 7051 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR---LLTGSLEAVQVQVDNLQNLQD 7107
Query: 4484 ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKF 4543
+LEK + S + +L+ + + + L ++ W ++ E+
Sbjct: 7108 DLEKQERSLQKFGSITNQLLKECHPP----VTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7163
Query: 4544 LDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLH- 4602
+L+L +++ +T++ +D ++L + I +V A I++ D L
Sbjct: 7164 KALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV--ATWIQDCNDLLKG 7221
Query: 4603 -----EELEFIRILGADL---IFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654
+ L F+ LG L + A + + S+ + A E + L K +
Sbjct: 7222 LGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE-------QALCKQQT 7274
Query: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTM-----PPVGTDLNTVKDQLNEMKEFKVEVYQ 4709
++QA V +T + L+ +++ + P +DL+T+++++ E+K ++
Sbjct: 7275 SLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSS 7334
Query: 4710 QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLAL 4769
++++LN G + D++I R + L W + + R KL+ LL
Sbjct: 7335 MAPDLDRLNELGYRL-----PLNDKEIKR--MQNLNRHWSLISSQTTERFSKLQSFLLQH 7387
Query: 4770 GQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNK 4829
F E M +L TE+ L + ISG+ + + + H + + ++ + Q + ++
Sbjct: 7388 QTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7445
Query: 4830 AGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS---EIE 4886
G LLE DD +L ++ W+ V+++ ++R + S ++Q Q + ++
Sbjct: 7446 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7505
Query: 4887 DFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE-TYNQLLDKGRLMLL 4945
+L+E++ + S P +P L ++ ++ +++ +Y ++ G+ +LL
Sbjct: 7506 KWLVEVSYLPMSGLGSVP---IPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7562
Query: 4946 SRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLA 5005
S D SG+ + + +A +++KW S ++EE+K KL L + + + + + L
Sbjct: 7563 SAD-SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTF 7621
Query: 5006 EQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLI 5065
++ L+ + P + ++ K N V + D + +L + L D+ ++
Sbjct: 7622 KKKLSQSLPDHH--EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7679
Query: 5066 KNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS 5125
+ +Q +WE++ + R + + + F E K+L +WL ES + +I
Sbjct: 7680 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7739
Query: 5126 NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDK 5185
+ KL+ +E K + R +A E + +++ LG+V D+
Sbjct: 7740 IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESK-----ASEIEYKLGKVNDR 7794
Query: 5186 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL---DLVM 5242
W + R KL+E L+ Q + +L WL +E +LA+ P+ D + +
Sbjct: 7795 WQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQ 7852
Query: 5243 NLMDAHKVFQKELGKR-TGTVQVLKRSGRELIENSRD------DTTWVKGQLQELSTRWD 5295
++ + Q+++ K TG VL E++ + D + ++ + L RW
Sbjct: 7853 RKLNEQQELQRDIEKHSTGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWR 7910
Query: 5296 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDT 5355
+C +S+ ++ ++E+ + + F D +WL +E+T A P + + ++
Sbjct: 7911 NICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT----AAFPSSSGVIYTVA-- 7964
Query: 5356 HKEFMKKVEEKRVDVNSAVAMGEVI-------LAVCHPDCITTIKHWITIIRARFEEVLT 5408
KE +KK E + V+ + E+I D ++K + R++ +
Sbjct: 7965 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8023
Query: 5409 WAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDR-----VKAL 5463
+RL+ + + + +L W+ + L NI+ V+A
Sbjct: 8024 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL---------TNIEHFSECDVQAK 8074
Query: 5464 IAEHQTFMEEMTRKQPDVDRVTKTYKR--KNIEPTHAPFIEK 5503
I + + F +E++ ++++ ++ + EP A IE+
Sbjct: 8075 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE 8116
Score = 313 bits (802), Expect = 3e-84
Identities = 717/4064 (17%), Positives = 1574/4064 (38%), Gaps = 528/4064 (12%)
Query: 1796 NVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLC----QAKVLEREL 1851
+VF Q CLE+ LVS ++L + + Q+ LE L + LL Q +LE +
Sbjct: 2943 SVFQTQSCLEN---LVSQMALSE--QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKN 2997
Query: 1852 KDLTTLV----SQELECVNQIIISQPQEVPAQL--LKALEKDAKNLQKSLSSVSDTWNSR 1905
D + QE+ Q + +++ +QL L +D +S + +N
Sbjct: 2998 TDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCL 3057
Query: 1906 LLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLI--------------------L 1945
L + K ++L Q + +D + W+ N + +
Sbjct: 3058 CLQASKGCQ-NKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKI 3114
Query: 1946 NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQ-----LDALAFDIQFFISEHAQDLSP 2000
S SE LN+ L + E L + + KA+ + A D + F S Q S
Sbjct: 3115 QEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESA 3174
Query: 2001 QQNRQM-LRLLNELQRSFQDILEQTAAQVDALQGHLQQM-----EQEALVKTLQK----- 2049
+N ++ ++ QD L +T V L + EQ+ L L++
Sbjct: 3175 LENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYE 3234
Query: 2050 -QQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSF 2108
Q N ++ + L W GQA H+ AL + D I F
Sbjct: 3235 PQLNRLKEKAQQL--WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQF 3292
Query: 2109 ATVVKDIEGFMEENQTKL-SPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 2167
+ +K+++ +M + L S T+ + L + EAL + +KE++ +
Sbjct: 3293 SLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQ--EKEIQMKMIVTR 3350
Query: 2168 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGM-----EQLSGASLEKG 2222
+ ++ + + + ++++ ++ D S+ S+G + + L G G G
Sbjct: 3351 GESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3410
Query: 2223 ALDTTDGYMGVN--QAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLT 2280
+D+ + + + Q E DK + KA+ LL+++ +L+ S ++ G +T
Sbjct: 3411 WMDSMEANLNESERQHAELRDKTTMLGKAK---LLNEE---VLSYSSLLETIEVKGAGMT 3464
Query: 2281 PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL 2340
E + Q +L +L+E+Y +++ + + + L Q++ +D K FE WL + +++L
Sbjct: 3465 --EHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKL 3522
Query: 2341 ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI 2400
+ S+L+ E + +L+ GQ +L+ +E PS I
Sbjct: 3523 DQY-----------SVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGI 3571
Query: 2401 GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL 2460
L+ + + A + + + N ++ + + + W++ E
Sbjct: 3572 PQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE----- 3626
Query: 2461 LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2520
K+ EE+ ++ VE++ A++I+ D HV
Sbjct: 3627 -------------------KKWHEEVTAYRDEVEEVGARAQEIL--------DESHVNSR 3659
Query: 2521 ----TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG--KQ 2574
+ S +Q+L + E+ L++ I + + SL S G +N + +
Sbjct: 3660 MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATK 3719
Query: 2575 VSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVS 2634
+ + + ++ + L T L +D+ + S L++ RE R ++ + A L+ ++ +
Sbjct: 3720 IDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779
Query: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF-- 2692
++ ++L +++ +L+K L A+ F L Q++ +L +P ++
Sbjct: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
Query: 2693 ----FQQIQELNLEMEDQ--------------------QENLDTLEHLVTELSSCGFAL- 2727
++ +Q+ L E ++ +D L+ +L S G A+
Sbjct: 3840 QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMM 3899
Query: 2728 -DLCQHQDRVQNLRKD--------FTELQKTVKER-------EKDASS--CQEQLDEFRK 2769
++ +DR+ NL+ LQ +K+ KD+ S C ++
Sbjct: 3900 EEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQS 3959
Query: 2770 LVRTFQK-------------WLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASKG 2815
L QK WL + + P+ + +S E KQ++H ++L + +
Sbjct: 3960 LEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE----QA 4015
Query: 2816 TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL-TEIQCDM 2874
++ C L N ++ TA D Q +I + + G+ K L +E+ +
Sbjct: 4016 RTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYL 4075
Query: 2875 SD----------------VNLKYEKLGGV------LHERQESLQAILNRMEEV------- 2905
D +N+ + V L +Q S+ I+ ++ ++
Sbjct: 4076 QDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESP 4135
Query: 2906 -HKEANSVL-QWLE-----------SKEEVLKSMDAMSSPTKTET------------VKA 2940
HKE N + QWL+ +E++ ++ D E ++
Sbjct: 4136 EHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARS 4195
Query: 2941 QAESNKAFLAELEQNSPKIQKVKEALAGL------LVTYPNSQEAENWKKIQEELNSRWE 2994
AES L L++ + +Q+ K A+ L ++ + N + E K+ L RW
Sbjct: 4196 DAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWF 4255
Query: 2995 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ 3054
+ ++ + + + L Q+ +L W E++ + S P+M
Sbjct: 4256 QLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMD 4315
Query: 3055 VQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE-LTDKLNS 3113
+ E EA++ + L + A ++ D+ L+ QV ++ S Q V L+D +
Sbjct: 4316 HLAICSELEAKQMLLKSLIKDADRVMA---DLGLNERQVIQKALSDAQSHVNCLSDLVGQ 4372
Query: 3114 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 3173
R +++A+ + TQ+ + + +++ +++ + I P+ V +Q++ ++ L
Sbjct: 4373 RRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASL 4432
Query: 3174 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA 3233
+ +EV EL + EQ K E+ +L+ + + + R+ L+ L
Sbjct: 4433 KTYQNEVTGLWAQGRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLV 4491
Query: 3234 STQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVI 3293
S + F++ FD+ WL + + L +QL + + + ++ +
Sbjct: 4492 SRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTL 4551
Query: 3294 VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 3353
G+++L S+ + L +L L + + D+ ++++ + ++Y +E
Sbjct: 4552 QRTGQTILPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE 4610
Query: 3354 DLVPWIEDCKAKMSELRVTLDPVQLESSLLRS---KAMLNEVEKRRSLLEILNSAADILI 3410
+ + +A+ + + +E +L +A+L+EV ++ LN +
Sbjct: 4611 LTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR 4670
Query: 3411 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 3470
++ + + + + TE+ + LE+ T +E ++ + +E++++ K
Sbjct: 4671 STGQPWQPDKMLHLVTLYHRLKRQTEQ---RVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4727
Query: 3471 HQLEIFDALGSQACSNKNL----EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP--DGS 3524
+ Q+ N+ EKL+ + +L+ L+ T L + AP D
Sbjct: 4728 EE---------QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPL 4778
Query: 3525 DASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDG 3584
+ HQ + Q E + + E+++ F + L + EL G
Sbjct: 4779 AYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG 4838
Query: 3585 MGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEA 3644
+ + +Q +I +++ ++ + A + + + L L+ L
Sbjct: 4839 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4898
Query: 3645 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEII 3704
L++ G + E + RQ L + + +Y+ + ND A+E L G +VE
Sbjct: 4899 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESA 4957
Query: 3705 NQQLADFKMFQKEQVDPLQMKLQQVNGLG---QGLIQSAGKDCDVQGLEHDMEEINARWN 3761
+ L F + D L++++ L LI+ GK+ LE + + R
Sbjct: 4958 EENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLIKPTGKE----DLEQKVASLELRSQ 5012
Query: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIAN-QKPPSAEYKVVKAQIQ 3820
+++ ++ LQ +Q A E ++ + DTE+ ++ ++ + ++
Sbjct: 5013 RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLS 5072
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
E K L +++ + L+ + ++ ++ A + ++ + ++ RWT L + A ++
Sbjct: 5073 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQE 5132
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
K LED + F+ + ++ + + KL S A++ + H ++E
Sbjct: 5133 KILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5192
Query: 3941 HATDVHQAVKIGQSLSSLT-----SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQA 3995
+ + + Q+LS L +P E+ L ++I ++Q R +Q++ L+ Q
Sbjct: 5193 QQSALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
Query: 3996 LSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD 4055
L + + V W+ E ++ L + ++ + Q + L E N ++N++
Sbjct: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQNIE 5304
Query: 4056 QAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTY 4115
K + ++ G +L E + + A++ + K ++ + + ++T
Sbjct: 5305 ---KMAEEQKEKYLGLYTILPSE----LSLQLAEVAL-DLKIRDQIQDKIKEVEQSKATS 5356
Query: 4116 EELTGWLREVEEELATSGGQ-SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN----EVS 4170
+EL+ ++++ ++L T + + + Q + QK L +E LD N E+
Sbjct: 5357 QELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEE-------LDGCNSKLMELD 5409
Query: 4171 RALLELVPWRAREG--LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAEL 4228
A+ + + + G L K + E ++ R+ +++ A ++Y + + L
Sbjct: 5410 AAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELIL 5469
Query: 4229 AWVAETKRKLMALGPI------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 4282
W+ K K++A G I +L + Q ++++ ID ++M E + + +
Sbjct: 5470 KWIE--KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSV 5525
Query: 4283 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 4342
+ C E+ + ++ L ++ E + + R L+ A + +F ++L +E+
Sbjct: 5526 Y--CTEK----MSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
Query: 4343 TRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM- 4401
+A L SP + L++Q + L + KP + + L+ +
Sbjct: 5580 AQAT---LTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
Query: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
+ + + ++++ Q+ + AV Q Q + +++ + + +E +
Sbjct: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDK 5693
Query: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521
P+ + + +++ IS ++ +++ Q +L + + L +++ A L E++
Sbjct: 5694 PVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGL 5753
Query: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP---- 4577
+ ED+ V+ + + + + +T + ++ SP
Sbjct: 5754 AEGT----EDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 5809
Query: 4578 ----------GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEV 4627
++ I Q +AE ++ + +H + + G +P
Sbjct: 5810 SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSA 5862
Query: 4628 RKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG 4687
+ ++ +WE L E+ L +A++ +YQD+LQ++ ++ +KL P G
Sbjct: 5863 TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG 5922
Query: 4688 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTEL 4744
+ + Q+ E + E+ Q E+ +L E ++ ++ D ++ ++ LT L
Sbjct: 5923 ---RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVL 5979
Query: 4745 KHLWENLGEKIAHRQHKLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQR 4794
+ K + ++ LE L AL +++ +EL SWL T+ LD
Sbjct: 5980 AERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTAL 6039
Query: 4795 PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRS 4848
+P +E +L +N ++ + V +++ N LLE A D+A L
Sbjct: 6040 SPPKEPMDMEAQLMD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAG 6096
Query: 4849 RLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGL 4908
+L + + + +++ +Q T Q+ + S+++ + ++ L+ ++ T
Sbjct: 6097 KLRRLKGSLLELQRALHDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--W 6152
Query: 4909 PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWH 4968
+ + L EL +L ++ + +G +L+ + + + +L Q+
Sbjct: 6153 TQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-- 6210
Query: 4969 VVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE 5028
ME KS E+ + + ++++ QEF S +L VL Q +E
Sbjct: 6211 ---LGMEGEKSSAEDQMRM--KWESLHQEF--------------STKQKLLQNVLEQEQE 6251
Query: 5029 HKVFANEVNAHRDQIIELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERG 5087
+++ ++++ +G L K QD + +LL + +E+V S + G
Sbjct: 6252 QVLYSRP-----NRLL----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSG 6299
Query: 5088 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGG 5147
+ + ++ ++ WL+D E L + P++ + L + K +
Sbjct: 6300 GAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKE 6357
Query: 5148 KQPVYDTTIRTGRALKEKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVER 5196
D K K L PE+ D LG + V + +
Sbjct: 6358 MSEEMD---------KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQM 6408
Query: 5197 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKE 5254
+ +L++ L F +L D Y + +LA +QPV ++ + D K F
Sbjct: 6409 KERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD-- 6466
Query: 5255 LGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQ 5314
G +++ +R + +E +L +L +D + + S++S L Q L
Sbjct: 6467 ----AGIIELKRRGDKLQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTL 6516
Query: 5315 AEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSA 5373
+ + L + L ++ + + + E +Q L+D HKE+ + +E +
Sbjct: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI----- 6571
Query: 5374 VAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAE 5429
+ F +++++A Q + + T L S ++ A
Sbjct: 6572 ------------------------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAH 6607
Query: 5430 LLEELLAWI--QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKT 5487
L +I W+ + DQ+ + + ++ V++ I E R +DR+T
Sbjct: 6608 KRGVELEYILETWSH---LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLY 6661
Query: 5488 YKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLA 5547
K+ + P + + G++ L +S S+ ++ ++NQL W
Sbjct: 6662 QHLKSSLNEYQPKLYQVLDDGKRLLIS--------ISCSDLES-QLNQLGECW------- 6705
Query: 5548 LERQRKLNDALDRLEE-LKEFANFDFDVWRKKYMRWMNHKKSRV 5590
L K++ L RLE LK + + + + W+ K R+
Sbjct: 6706 LSNTNKMSKELHRLETILKHWTRYQSE--SADLIHWLQSAKDRL 6747
Score = 306 bits (785), Expect = 3e-82
Identities = 683/3822 (17%), Positives = 1496/3822 (39%), Gaps = 459/3822 (12%)
Query: 1836 ELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLK---ALEKDAKNLQ 1892
E Q C L RE ++L + VS+ LE + +I+++ + LK + + AKN
Sbjct: 2083 ENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKM 2142
Query: 1893 KSLSSVSDTWNSRLLHFQNAV-------------EIEKT--KVLNQHTQLEGRLQDLRAW 1937
D + S+ H + + ++E T K L+ +LE + LR
Sbjct: 2143 NYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVS 2202
Query: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997
+ + +L+++ EI+ S N Q E++ + + + L + + + A
Sbjct: 2203 LSIWDDVLSTR---DEIEGWSNNCVPQMAENISN--LDNHLRAEELLKEFESEVKNKALR 2257
Query: 1998 LSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG--HLQQMEQEA--LVKTLQKQQNT 2053
L ++ + L EL ++ + + + D +Q H +++ + A +K Q
Sbjct: 2258 LEELHSK--VNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQ 2315
Query: 2054 CHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVK 2113
+ + D+ +W + E +L T + AL+K +KD+Q ++Q++ ++ ++ +
Sbjct: 2316 VEKFINDITTWFTKVEESLMNCAQNETCE---ALKK----VKDIQKELQSQQSNISSTQE 2368
Query: 2114 DIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEK 2173
++ K EL +L + +++EA+ + Q L+E++ E
Sbjct: 2369 NLNSLCR----KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL------EKHF 2418
Query: 2174 SKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGV 2233
S++ +E E W L + K + D T
Sbjct: 2419 SESMQEFQE----------WF-------------------LGAKAAAKESSDRTG----- 2444
Query: 2234 NQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD---QHGH----NLTPEEQQM 2286
++++A+ +L QN + + Q+ LD Q G +L+ +
Sbjct: 2445 ---------DSKVLEAKLHDL----QNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSS 2491
Query: 2287 LQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKG 2346
+Q+++ + E++ L Q + + +Q EL F H++ W+ E+ N
Sbjct: 2492 IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERF-NTENL 2550
Query: 2347 GSSPETLPSL---LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNL 2403
G S + +P + + F ++++ + L ++ GQ + + EG + G L
Sbjct: 2551 GESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE------EGHGAGQEGRL 2604
Query: 2404 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 2463
L T L +L S + L ++ + + S+ W++A + + ++
Sbjct: 2605 CSQLL---TSHQNLLRMTKEKLRS-CQVALQEHEALEEALQSMWFWVKAIQDRLA--CAE 2658
Query: 2464 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2523
+ L+++L+ + + E +V + + + + R +Q ++
Sbjct: 2659 STLGSKDTLEKRLSQIQDILLMKGEGEVKLN--MAIGKGEQALRSSNKEGQRVIQTQLET 2716
Query: 2524 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK---QVSSLSS 2580
+ + + S S L+ I+Q E L Q + V+Q +E Q
Sbjct: 2717 LKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEK 2776
Query: 2581 GVIQEALATNMKLKQDIARQKSSLEA-TREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2639
V+ + L + + +D R L A +RE+ + + + TA E+ +F
Sbjct: 2777 FVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ------EELKTQFND 2830
Query: 2640 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2699
+ +EK +++++ M+ + ++ + L + D + +++ ++
Sbjct: 2831 IMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKI 2890
Query: 2700 NLEMEDQQE----NLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2755
E+ D +E L +E L E+ A +Q LR D+ + + +V + +
Sbjct: 2891 K-ELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ- 2948
Query: 2756 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKG 2815
SC E L ++ ++ E S +LE+ +E +LL WA +
Sbjct: 2949 ---SCLENL---------------VSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQL 2990
Query: 2816 TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMS 2875
TL+E N +E D+ K + S + + + +DL+ +S
Sbjct: 2991 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS--RDLSTYSGKVS 3048
Query: 2876 DVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKT 2935
+ +Y L + ++ + IL + K QWL + + + + P
Sbjct: 3049 GLIKEYNCLCLQASKGCQNKEQILQ--QRFRKAFRDFQQWLVNAK--ITTAKCFDIPQNI 3104
Query: 2936 ETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWER 2995
V + + FL+E E K+ + LL T ++A+ + W+
Sbjct: 3105 SEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTAAKEDWKN 3163
Query: 2996 ATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQV 3055
++ LE + F+ + ++ WL + E M+ D ++Q++
Sbjct: 3164 FHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKL 3223
Query: 3056 QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRS 3115
Q +L+E Q +L E AQ + G ++ + + ++ +++ L++ +
Sbjct: 3224 QSVLEEIHCYEPQLNRLKEKAQQLWEGQA----ASKSFRHRVSQLSSQYLALSNLTKEKV 3279
Query: 3116 SQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQ 3175
S++D+ + + Q+ +++L + + L P + K L+ + LE
Sbjct: 3280 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC----HPTSDKSVLDSRT---LKLEA 3332
Query: 3176 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN-------RL 3228
L VK+ + + ++ V GE L++ + + T+ LQ ++D+ A ++ +L
Sbjct: 3333 L-LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3391
Query: 3229 QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSG 3288
+ AL+ +Q + W+D ++ ++ A+L + L + + + + +S
Sbjct: 3392 EGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSS 3451
Query: 3289 SYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY 3348
E I +G + E Q +L +L+ + + ++ + ++ + ++ Q+Y
Sbjct: 3452 LLETIEVKGAGMT-------EHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEY 3504
Query: 3349 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS--KAMLNEVEKRRSLLEILNSAA 3406
Q ++ W+ + K+ + V + LR + ++ E + L +L++
Sbjct: 3505 QRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE 3564
Query: 3407 DILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIE--- 3463
D++ + ED + + Q+ A L + +LR ++ F+ ++
Sbjct: 3565 DVIPSGIPQAEDRALES---LRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWL 3621
Query: 3464 KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDG 3523
K E K E+ +++ + V + Q L + Q L+
Sbjct: 3622 KTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL------ 3675
Query: 3524 SDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD 3583
Q+L Q + ++E +++ E+ L ++ + F +A D++D
Sbjct: 3676 ---LQVLEQIKFLEEEIQSLEES--------ESSLSSYSDWYGSTHKNFKNVATKIDKVD 3724
Query: 3584 GMGAIGRDTDSLQSQIEDVRLFLNKIH-VLKLDIEASEAECRHMLEEEGTLDLLGLKREL 3642
+ +G+ +L+ ++D + K H +LK E E +++ EEG + L ++E+
Sbjct: 3725 TV-MMGKKLKTLEVLLKD----MEKGHSLLKSAREKGERAVKYL--EEGEAERL--RKEI 3775
Query: 3643 EALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVE 3702
+Q +LT + LE L ++F K K L AE E L ++E
Sbjct: 3776 HDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQ--WIAEYQEILHVPEEPKME 3833
Query: 3703 IINQ--QLADFKMFQ-----------------------------KEQVDPLQMKLQQVNG 3731
+ + QL+ +K Q K+++D LQ Q +
Sbjct: 3834 LYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCS 3893
Query: 3732 LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKK------------------------- 3766
+G+ +++ ++ G E + + + +TL +
Sbjct: 3894 IGKAMME------EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYS 3947
Query: 3767 ----VAQRIAQ-LQEALLHCGKFQDALEPLLSWLADTE-ELIANQKPPSAEYKVVKAQIQ 3820
AQR+ Q L+ L QD L+ +WL+ + +L + +PP + + +K Q++
Sbjct: 3948 AICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIK-QVK 4006
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
+ LQ + + +D+L + D + + + + + TE
Sbjct: 4007 HFRALQ---EQARTYLDLL----------CSMCDLSNASVKTTAKDIQQTE--------- 4044
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI-E 3939
+ +E LV A+ + E I S L +++ ++Q RH LE +I +
Sbjct: 4045 QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ------QLQNMKRRHSELELNIAQ 4098
Query: 3940 NHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQAR-YSEIQDR---CCRKAALL- 3992
N + V VK QS + + + V L++K +S + + + + D+ CR++ L
Sbjct: 4099 NMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLC 4158
Query: 3993 ---DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVN 4049
++ L R + + V +L + + ++ D + +H + LAL +
Sbjct: 4159 LQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLAL--ALQE 4216
Query: 4050 RKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLAT 4109
RK ++ Q +++ ++ L++E+ ++ R+ + + ++ +
Sbjct: 4217 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELN 4276
Query: 4110 KFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 4169
QS ++EL W E + +A + QSP + + E+ +++L ++ +
Sbjct: 4277 VVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKD 4336
Query: 4170 SRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA 4229
+ ++ + R+ + K +SDA +SD +GQR ++ A+ Q+ A +
Sbjct: 4337 ADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATS 4396
Query: 4230 WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEE 4289
+ + +RK+M I L D + Q++ K+ + +++ + L++ E+ E+
Sbjct: 4397 QIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQ 4456
Query: 4290 QKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ 4349
+K+ + K + L Y+++ S R LE+ V F E +++ W+++ A I
Sbjct: 4457 EKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQ--ADIVT 4514
Query: 4350 LPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-LKELNPEEGEMVEEKY 4406
P + +E +L Q + + + E E++ + L + G L LN + + EK
Sbjct: 4515 FPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKL 4574
Query: 4407 QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA 4466
+ I + + + EA+ E+ IE ++L L ++ +P
Sbjct: 4575 NALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIELTTQSLSELEAQFLRMSKVPT 4631
Query: 4467 EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG-RSQGADKDLAAKEIQDKLDQM 4525
++ + E +S L+++ EA+ ++ G RS G DK+ +
Sbjct: 4632 DL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ------PDKMLHL 4684
Query: 4526 VFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS 4582
V + +K + E+R D + EK + L ++K+ Q V++ P
Sbjct: 4685 VTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPA---- 4740
Query: 4583 IIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN 4642
+++++ ++ L+ + I DL + R I + L
Sbjct: 4741 --EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLT 4798
Query: 4643 KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKE 4702
E + + E M ++ +Q + DWL +K PV DLN ++D E++
Sbjct: 4799 SAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAELSGPVYLDLN-LQDIQEEIR- 4854
Query: 4703 FKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4757
K++++Q++++ M L+H+ + KA + D + L EL L ++ E +
Sbjct: 4855 -KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-LEHSLAELSELDGDIQEALRT 4912
Query: 4758 RQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG---DPKVIEVELAKH---- 4810
RQ L ++ + WL +ELL ++G D + E L H
Sbjct: 4913 RQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----LAGNGLDVESAEENLKSHMEFF 4968
Query: 4811 ------HVLKNDVLAHQATVETVNK-AGNELLESSAGDDASSLRS-RLEAMNQCWESVLQ 4862
H ++ + AT++ + K G E LE + LRS R+ + +LQ
Sbjct: 4969 STEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA--SLELRSQRMSRDSGAQVDLLQ 5026
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4922
+ + Q ++ ++ E L E + +++ S A E+L H L
Sbjct: 5027 RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS---------HEAEEKLSEHKAL 5077
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
S + + E L +K + + +D+ S + +S+ + Q+W + + ++++ LE
Sbjct: 5078 VSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMTTVWQRWTRLRAVAQDQEKILE 5136
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
+A++ T F N +++ + + L +S +L+ +E H F
Sbjct: 5137 DAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTF---------- 5186
Query: 5043 IIELDQTGNQLKFLSQKQDVVL-------------IKNLLVSVQSRWEKVVQRSIERGRS 5089
++EL+Q + L L Q+ +L + + ++Q R + ++ G+
Sbjct: 5187 VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKL 5246
Query: 5090 LDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLSKHKEFQKTLGGK 5148
+ K + + W+++ + +L + +EI +++++ L++ ++ +
Sbjct: 5247 VKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIE-- 5304
Query: 5149 QPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGEVRDKWDTVCGKSVERQHKLEE 5202
+ KEK T+LP + S +L +++ + D + K E +
Sbjct: 5305 --------KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIR-DQIQDKIKEVEQSKAT 5355
Query: 5203 ALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV 5262
+ S Q + L L K++ + D V+ KV +EL +
Sbjct: 5356 SQELSRQIQKLAKDLTTILTKLKAK----------TDNVVQAKTDQKVLGEELDGCNSKL 5405
Query: 5263 QVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 5322
L + ++ +E + + ++ +L+ + + ++ S+L QA E + + +
Sbjct: 5406 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 5465
Query: 5323 HMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA 5382
++L+W+ +A + L + L+ H+ ++ E K +D + AM E +
Sbjct: 5466 ELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE--ESKEID-SELEAMTEKLQY 5521
Query: 5383 VCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAE 5442
+ C + + + EE+ K Q L+ A ++ L++L A ++ A+
Sbjct: 5522 LTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ 5581
Query: 5443 TTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484
TL + + +K ++ Q + EM +P V V
Sbjct: 5582 ATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKVQAV 5618
Score = 294 bits (753), Expect = 2e-78
Identities = 649/3534 (18%), Positives = 1379/3534 (39%), Gaps = 370/3534 (10%)
Query: 1814 LSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQP 1873
L LR ++ L+LNL ++Q+ + + ++ + E V L +N + +
Sbjct: 4826 LDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE-------VQSSLRIMNALSHKEK 4878
Query: 1874 QEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD 1933
++ KA E + +L+ SL+ +S+ Q A+ + + ++Q + Q
Sbjct: 4879 EK----FTKAKELISADLEHSLAELSELDGD----IQEALRTRQATLTEIYSQCQRYYQV 4930
Query: 1934 LRA---WVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFF 1990
+A W+ + +L G+ +DV+S L+ + + + + L+ ++
Sbjct: 4931 FQAANDWLEDAQELLQLAGNG--LDVESAEENLKSHMEFFSTEDQFHSNLE----ELHSL 4984
Query: 1991 ISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG-----HLQQMEQEALVK 2045
++ + P + + + L+ Q + + AQVD LQ H Q +E +++
Sbjct: 4985 VATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIE 5044
Query: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTT-----QQDLSALQKNQSDLKDLQDD 2100
+ + + S +AE L+ H+ + + + AL++ S L+ +D
Sbjct: 5045 LMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5104
Query: 2101 ------------IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEAL 2148
+ R T V +D E +E+ + E T K+ +A E + L
Sbjct: 5105 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILED-----AVDEWTGFNNKVKKATEMIDQL 5159
Query: 2149 QEET--RVAQKELEEAVTSALQQ------ETEKSKAAKELAENKKKIDALLDWVTSVGSS 2200
Q++ A+K + + + L+ E E+ ++A + ++ + L D
Sbjct: 5160 QDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR-QQTLSMLQDGAAPTPGE 5218
Query: 2201 GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEK--LDKQCEMMKARHQELLSQQ 2258
L+ + M+ EK T+G + + ++ ++ Q +K QE
Sbjct: 5219 EPPLMQEITAMQDRCLNMQEKVK---TNGKLVKQELKDREMVETQINSVKCWVQETKEYL 5275
Query: 2259 QNFILAT----QSAQAFLDQ---HGHNLTPEEQQMLQQKLGE---LKEQYSTSLAQSEAE 2308
N + + Q L + H N+ ++ ++ LG L + S LA+ +
Sbjct: 5276 GNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALD 5335
Query: 2309 LKQVQTLQDELQKFLQDH---KEFESWLERSEKELEN-MHKGGSSPETLPSLLKRQGSFS 2364
LK +QD++++ Q +E +++ K+L + K + + + Q
Sbjct: 5336 LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLG 5395
Query: 2365 EDVISHKGDLRFVTISGQKVLDMENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKC 2422
E++ L + + QK L+ + K+ ++ L + ++ A R + L+
Sbjct: 5396 EELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAA 5455
Query: 2423 TRLGSH---LNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL-AT 2478
+ L + L ++L + + A AW A + + +L T+ + + +L A
Sbjct: 5456 SHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAM 5515
Query: 2479 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER 2538
T++LQ + V +K+++ + E+ R +E I Q+L
Sbjct: 5516 TEKLQ-----YLTSVYCTEKMSQQVAELG-------RETEELRQMIKIRLQNL------- 5556
Query: 2539 SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIA 2598
Q A + + L+ L ++ + + L +V LS ++E L+ L ++
Sbjct: 5557 ----QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---LKEQLSHRQHLLSEME 5609
Query: 2599 RQKSSLEATREMVTRFMETADSTTAAVLQG---KLAEVSQRFEQLCLQQQEKESSLKKLL 2655
K ++A + + D + L +L E + R + +QQ + ++ +
Sbjct: 5610 SLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC---NIMQAAV 5666
Query: 2656 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI---QELNLEMEDQQENLDT 2712
Q E +E LQQ +E R + +I QI +EL +++ QE + +
Sbjct: 5667 VQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIAS 5726
Query: 2713 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR 2772
L S C ++ ++ + TV E E A ++ E
Sbjct: 5727 LN------SKC-----------KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPS 5769
Query: 2773 TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLI 2832
+ T G T +S E E S + + + N + +++
Sbjct: 5770 AHPSVVMMTAGRC---HTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIA 5826
Query: 2833 --MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHE 2890
++A Q I PS +S ++ + D+ +E L V+ E
Sbjct: 5827 YYQALSAERLQTDAAKIHPSTSAS----QEFYEPGLEPSATAKLGDLQRSWETLKNVISE 5882
Query: 2891 RQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLA 2950
+Q +L L R ++ S+ +E+ E L SP + ++Q ++A +
Sbjct: 5883 KQRTLYEALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMD 5937
Query: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR----- 3005
E+ +I +++ +LA LV+ + +Q L ER + + +
Sbjct: 5938 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 5997
Query: 3006 ------QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQF 3057
QLEE A ++ +L WL+ + + +P + AQ Q
Sbjct: 5998 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6057
Query: 3058 MLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSS 3116
ML E E + +L+ + +L G Q+ +L+ + +EL L+ +
Sbjct: 6058 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-- 6115
Query: 3117 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL 3176
Q ++ T ++ D+ Q VQ ++ QQ + + + + +LEQ
Sbjct: 6116 ---QLNMQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ- 6168
Query: 3177 DHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ 3236
E+ E ++L ++ GE+ L ++ A G A ++ + L L
Sbjct: 6169 --ELAEQKSLLRSVASR-GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEG 6215
Query: 3237 QFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE 3296
+ D++R + + S K + LQ+ L++ +E +V+ +
Sbjct: 6216 EKSSAEDQMRMKWESLHQE------FSTKQKLLQNVLEQEQE------------QVLYSR 6257
Query: 3297 GESLLLSVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKY 3348
LL VP P ++K + + L L +EE+S ++ A RQS + QK
Sbjct: 6258 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKL 6312
Query: 3349 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 3408
V W++D + ++ + L P + E+ L + + ++++ ++ +
Sbjct: 6313 YDGVSATSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQ 6371
Query: 3409 LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEG 3468
+ + D I D + + + + + ++E Q++ FQ K + +
Sbjct: 6372 AFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLAD 6431
Query: 3469 AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQ 3528
K+ + Q +N + + Q E +Q E D L+ F G++E G
Sbjct: 6432 NKYII-------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK--- 6478
Query: 3529 LLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGA 3587
L + + QE +++ + +++ ++ G+ Q + L DL D L+ G
Sbjct: 6479 -LQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEK 6537
Query: 3588 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE- 3643
+ D + S E+++ L+K +E+ HM+ E + +++E +
Sbjct: 6538 MAGDQKIIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQF 6591
Query: 3644 --ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3701
L Q + +R R +LE L E + + + + E E+ VG
Sbjct: 6592 HTELMAQASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVE 6648
Query: 3702 EIINQQLADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINAR 3759
E ++ + ++Q K ++ Q KL QV G+ L+ S LE + ++
Sbjct: 6649 ENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGEC 6704
Query: 3760 WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVV 3815
W + K+++ + +L+ L H ++Q L+ WL ++ + S E ++V
Sbjct: 6705 WLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMV 6764
Query: 3816 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3875
+ + + +D + + + + G ++ + ++ D + +L ++S+WT+LL+
Sbjct: 6765 RDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTN 6823
Query: 3876 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIR 3930
A Q++L + + + ++S+ E + E +G + I + + +
Sbjct: 6824 IPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQK 6881
Query: 3931 HKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDR 3984
+K + DI V + QS+ ++S + S+K D ++ + +Q
Sbjct: 6882 YKGFKIDINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGL 6938
Query: 3985 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN 4044
K LL+ L + + E+ V+ L E ++K + Q + D L
Sbjct: 6939 VTEKIQLLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 6997
Query: 4045 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 4104
+ I ++K V++ +NG AL++ + ++ L + +A++ + L+
Sbjct: 6998 DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSV 7057
Query: 4105 RQLATKFQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHR 4160
+ + ++++ +L E L+ +G Q+ Q Q +L+K+
Sbjct: 7058 LDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS-- 7115
Query: 4161 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 4220
L ++ LL+ E L + + N ++ + + I +++ A +Q Q+Y
Sbjct: 7116 --LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY 7173
Query: 4221 E----QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELF 4276
+ Q A T L A + D+ +Q + KDS+ L
Sbjct: 7174 KDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLH 7233
Query: 4277 SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 4336
++ + +Q SL Q A+ ++ L+ + F ++ E L
Sbjct: 7234 ELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEAL 7293
Query: 4337 SPWIEETRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 4395
WI E ++ Q PS + D ++++ EE++ + P +D+L ++G +L LN
Sbjct: 7294 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LN 7352
Query: 4396 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 4455
+E ++ Q ++ I + +R L + Q F +K E +E L
Sbjct: 7353 DKE----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTE 7405
Query: 4456 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA 4515
+L + I + E ++ E+ Q ++ G+ L+ + Q D+D
Sbjct: 7406 QKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD--- 7460
Query: 4516 KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLE 4575
E KL + W+ + RA++R +++ + W + ++ V L
Sbjct: 7461 -EFNLKLTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7515
Query: 4576 SPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA---------DLIFACGETEKPE 4626
G+ I Q A T+ +E +E F+R G+ L+ + +
Sbjct: 7516 MSGLGSVPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA 7571
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
++ + E+ W++ + +E+ +KL ++ ++ + + D L+
Sbjct: 7572 LQAELAEIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADSLEK----------- 7617
Query: 4687 GTDLNTVKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DET 4732
L T K +L++ + + E++ +Q+ ++L + +L L K T
Sbjct: 7618 ---LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISAD 7674
Query: 4733 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4792
D I+ E + L+ WE L +++ R+ ++ L F +EL WLT E +
Sbjct: 7675 DISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ 7734
Query: 4793 QRPISGDPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4851
+GD + E +E K + +A + ++ + + G L ++S AS + +L
Sbjct: 7735 ----NGDILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLG 7789
Query: 4852 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGL 4908
+N W+ +L R ++L+ TL Q + L +ES+L+ KP
Sbjct: 7790 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCN 7847
Query: 4909 PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQ 4965
E + +L+ EL ++ +L+ ++L D + ++ + Q+ L++
Sbjct: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7907
Query: 4966 KWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ 5025
+W + + ER+ K+EE L +F + F +WL +E++ S +I +
Sbjct: 7908 RWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEE 7967
Query: 5026 IEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE 5085
+++ + F +V+ Q+ +++ +L ++ +K ++ RW+ + +R
Sbjct: 7968 LKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTS 8027
Query: 5086 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTL 5145
R L + ++F A ++ WL + + L + +E ++ D ++ ++ + K FQ+ +
Sbjct: 8028 ILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEI 8085
Query: 5146 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
+ I G L EK+ P D+ ++ L E+R V G+ VER HK
Sbjct: 8086 SLNHNKIEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHK 8137
Score = 266 bits (680), Expect = 5e-70
Identities = 655/3611 (18%), Positives = 1409/3611 (39%), Gaps = 399/3611 (11%)
Query: 1883 ALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD--------L 1934
ALE+ A L+K+ + S SR + T V + T+L QD +
Sbjct: 5090 ALEEKASQLEKTGNDASKATLSRSM----------TTVWQRWTRLRAVAQDQEKILEDAV 5139
Query: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER--KAQLDALAFDIQFFIS 1992
W G N + K + ID Q + L AE+ KA+L L F+
Sbjct: 5140 DEWTGFNNKV---KKATEMID--------QLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5188
Query: 1993 EHAQDLSP--QQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA-----LVK 2045
E Q S +Q L +L + ++ A+Q M+++ LVK
Sbjct: 5189 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5248
Query: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGH------QGRTTQQDLSALQKNQSDLKDLQD 2099
K + Q+ + WV + + L Q Q L+ ++ +++ + +
Sbjct: 5249 QELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE 5308
Query: 2100 DIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKEL 2159
+ + + T++ E ++ + L + +++K+ + ++ QE +R QK
Sbjct: 5309 EQKEKYLGLYTILPS-ELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLA 5367
Query: 2160 EEAVT----------SALQQETEKSKAAKELAENKKKI----DALLDWVTSVGSSGGQLL 2205
++ T + +Q +T++ +EL K+ A+ ++ G G L
Sbjct: 5368 KDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLA 5427
Query: 2206 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA--RHQELLSQQQNFIL 2263
+ + +L ++ + + +NQA L++ EM++ + E + +
Sbjct: 5428 KKIGKLTELHQQTIRQAE----NRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTI 5483
Query: 2264 ATQSAQAFLDQHG-HNLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE-- 2318
A SA +Q+ H EE + + +L + E QY TS+ +E +QV L E
Sbjct: 5484 AWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETE 5543
Query: 2319 ------------LQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 2366
LQ +D K+FE+ L++ + LE +SPE LK Q S +
Sbjct: 5544 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 5603
Query: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
++S L+ Q V +++ + ++ L L+ E H+ +
Sbjct: 5604 LLSEMESLKPKV---QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCN 5660
Query: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
+ + QY Q++ LQ ++ +E S+ LQ Q++ ++L +++
Sbjct: 5661 I-MQAAVVQYEQYEQEMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKI 5717
Query: 2487 AEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI 2546
+Q + L + ++ ++ + A V E + + + L L S +
Sbjct: 5718 KGYQEQIASLNSKCK-MLTMKAKHATMLLTVTEV-EGLAEGTEDLDGELLPTPSAHPSVV 5775
Query: 2547 AQSQSVQESLES-LLQSIGEVEQNLE---------GKQVSSLSSGVIQE-----ALATNM 2591
+ +L S + + GE N E V++ + V Q+ AL+
Sbjct: 5776 MMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAE- 5834
Query: 2592 KLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSL 2651
+L+ D A+ S A++E +E S TA KL ++ + +E L EK+ +L
Sbjct: 5835 RLQTDAAKIHPSTSASQEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTL 5887
Query: 2652 KKLLPQAEMFEH----LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ 2707
+ L + + ++ +S K++ S G P+ + + E+ + ++
Sbjct: 5888 YEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEIN 5947
Query: 2708 ENLDTL-EHLVTELSSCGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSC 2760
E +L E LV+E A L +R+ +R + ++ ++E+ D
Sbjct: 5948 ELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEE 6007
Query: 2761 QEQ---LDEFRKLVRTFQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWA 2812
Q Q L +R WL T+ ++ PP E ++E Q+ +++L +
Sbjct: 6008 QRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIE 6063
Query: 2813 SKGTLVEEINCKGTSLENLIME---ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL-- 2867
K + E++ ENL++E T +++ G + GS + H K L
Sbjct: 6064 QKVVALSELSVHN---ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD-KQLNM 6119
Query: 2868 --TEIQCDMSDVNLKYEKLGGV-----------LHERQESLQAILNRMEEVHKEANSVLQ 2914
T + + SDV+L + GV +RQ SLQ +E+ E S+L+
Sbjct: 6120 QGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ-QKELEQELAEQKSLLR 6178
Query: 2915 WLESK-EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTY 2973
+ S+ EE+L A ET E EL K +
Sbjct: 6179 SVASRGEEILIQHSA------AETSGDAGEKPDVLSQELGMEGEK-------------SS 6219
Query: 2974 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKEL 3033
Q W+ + +E +++ + V Q Q+ S + + +K
Sbjct: 6220 AEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSA 6279
Query: 3034 MMGVLGPLS-----IDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSL 3088
+ +L L+ + A++Q + K ++ L++ + + +
Sbjct: 6280 VTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPE 6339
Query: 3089 STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV 3148
T + + + E++++++ + QA ++ +++++D + +G+ +
Sbjct: 6340 ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL--LGRLSLL 6397
Query: 3149 QSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE 3208
S ++ + +K++L++ ++DL+ L + + + + + + EQ + +++ E
Sbjct: 6398 DSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI----E 6453
Query: 3209 TVALPLQGLEDLAA---------DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKN 3259
+ GL++ A D++ Q ++ + Q M+DEL + ++S +N
Sbjct: 6454 AIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN 6513
Query: 3260 CPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE---------- 3309
+ ++ ER L + E + + +G ++IV+ E + + +E
Sbjct: 6514 LTLKSQYERALQDLADLLETGQE--KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI 6571
Query: 3310 -KRTLQNQLV------ELKNHWEELSKKTA----------------DRQSRLKDCMQKAQ 3346
TL +++ E + H E +++ +A + S L + Q+
Sbjct: 6572 LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELS 6631
Query: 3347 KYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAA 3406
+ VE +P + + L +D + L L K+ LNE + + L ++L+
Sbjct: 6632 RQLEVVESSIPSVGLVEENEDRL---IDRITLYQHL---KSSLNEYQPK--LYQVLDDGK 6683
Query: 3407 DILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV 3466
+LI+ S +D + + + + + T ++ + LE + + +Q ++ +
Sbjct: 6684 RLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6740
Query: 3467 EGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3526
+ AK +LE + + LE +R +VD + ++ S
Sbjct: 6741 QSAKDRLEFWTQ--QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVL------STG 6792
Query: 3527 SQLLHQAEVAQQEFLEVKQRVNS-------GCVMMENKLEGIGQFHCRVREMFSQLADLD 3579
+QLL +V R++S ++ KL + R S++
Sbjct: 6793 NQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 6852
Query: 3580 DELDGMGAIGRDTDSLQSQI--EDVRLFLNKIHVLKLDIEASEAECRHMLE--------- 3628
++ + I +D D++++ I + + +L K K+DI + + +
Sbjct: 6853 SLMENV--IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQD 6910
Query: 3629 -EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAA 3687
E D +L A+NK L + + LE L ++ ++ L
Sbjct: 6911 VESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 6970
Query: 3688 EEAEALQWVVGTEVEIIN-----QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK 3742
E+ Q +G + + N Q L D ++++V+ ++ NGL LIQ+ +
Sbjct: 6971 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLA--LIQNKKE 7023
Query: 3743 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3802
D + + E+ W L+ V Q L+ L + A + + S+L + +
Sbjct: 7024 DVSSIVMS-TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSL 7082
Query: 3803 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3862
+ + + + V+ Q+ + LQ L+ ++ ++ + ++ + E +T L
Sbjct: 7083 SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTL 7142
Query: 3863 ESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3922
+ + RW LL + A + + + +L L +++ + ++ + + E + T
Sbjct: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202
Query: 3923 KIQQQIIRHKALEEDIENHATDVHQAV----KIGQSLSSLTSPAEQGVLSEKIDSLQARY 3978
++ D+ V ++ ++G+ L + + SL
Sbjct: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262
Query: 3979 SEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHA 4038
++ C++ L + + F + + W+ E E+ L QD H +
Sbjct: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQG-------QDPSHS--S 7313
Query: 4039 DHLALNEEIVNRKKNVDQAIKNGQALLK-QTTGEEVLLIQEKLDGIKTRYADITVTSSKA 4097
D + E + K + + L + G + L +++ ++ ++ SS+
Sbjct: 7314 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7373
Query: 4098 LRTLEQARQLATKFQSTYEELTGWLR---EVEEELAT--SGGQSPTGEQIPQFQQRQKEL 4152
+ + + Q+ E+ W+ + E++LA SG EQ QR EL
Sbjct: 7374 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-----QRAHEL 7428
Query: 4153 -KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
+ E+ + +L ++ + LLE R+ + ++ + Q++ V QR ID
Sbjct: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
Query: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMA-LG--PIRLEQDQTTAQLQVQKAFSIDIIRH 4268
+ I++ Q+Y + A+ W+ E M+ LG PI L+Q +T +VQ + +R
Sbjct: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQ 7546
Query: 4269 KDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQ 4328
+ S ++ + + LQ + + +++++ S+ E+ +L + +
Sbjct: 7547 QGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL----AFLLK 7602
Query: 4329 FWETYEE-LSPWIEETRALIAQLPSPAIDH-EQLRQQQEEMRQLRESIAEHKPHIDKLLK 4386
WE E+ ++ +E+ R +L DH E+L +Q ++L ++ + +L
Sbjct: 7603 DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7662
Query: 4387 IGPQLKE-LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIE 4445
+ L ++ ++ ++ E+ + + + ++ ++ R + E +++ F +K +
Sbjct: 7663 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV---FSEKNK 7719
Query: 4446 PMLETLENLSSRLRMPP--LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4503
+ E L + S++ LI ++K+++ + + A + K+Q L++ GE L
Sbjct: 7720 ELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE-EIAIAQENKIQ-----LQQMGERLA 7773
Query: 4504 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4563
S + A EI+ KL ++ W+ + R K + L ++ +M++L T
Sbjct: 7774 KASH----ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7829
Query: 4564 IKDTQD-----IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFA 4618
+ + IV+D + + +Q E I++ + G+ L +L D
Sbjct: 7830 LAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 7889
Query: 4619 CGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVI 4678
+ E ++++ ++ W N+ ER K+E+ + ++ D DWL ++
Sbjct: 7890 ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 7949
Query: 4679 KLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-I 4737
G K++L + + F+ +V++ ++E +N Q + ++ + TD +
Sbjct: 7950 TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSL 8007
Query: 4738 REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPI 4796
++ + E W+NL +++ +L+ + +F+ A + ++ WLT + +L + +
Sbjct: 8008 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8067
Query: 4797 SGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQC 4856
D ++ ++ + + ++ + +E + G +L+E S DA+ + L+ + +
Sbjct: 8068 ECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY 8124
Query: 4857 WESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLEL------------TRMESQLSASKP 4904
+ V + E ++L L H ++ D LEL R L + +P
Sbjct: 8125 CQEVFGRVERYHKKL-IRLPLPDDEH-DLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
Query: 4905 TGGLP-------ETAREQLDTHMELYSQLKAKEETYNQLLDKGRLM---LLSRDDSGSGS 4954
+ L + R DT + S + Y+ D M L S D+ G
Sbjct: 8183 SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 8242
Query: 4955 KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLA--------E 5006
K + ++ E E A+ + ++L+ I L A +
Sbjct: 8243 KDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ 8302
Query: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
Q+ NI + + + + + E ++ D + L+ K +++ +
Sbjct: 8303 QTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEH-----KLKEEEESLPGFV 8357
Query: 5067 NL------LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD- 5119
NL V RWE + +++ + + ++ +QF+ + WL D E L+
Sbjct: 8358 NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 8417
Query: 5120 -SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 5178
LE+S D I+LQ+ K KE QK + ++ + + + ++S+ L +
Sbjct: 8418 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD--SKESRDLQDR 8475
Query: 5179 LGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL 5238
L ++ +WD VC E + L++AL+ F + L+ L ++ + E P+ +L
Sbjct: 8476 LSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNL 8535
Query: 5239 DLVMNLMDAHK 5249
D + L D HK
Sbjct: 8536 DAEI-LQDHHK 8545
Score = 261 bits (668), Expect = 1e-68
Identities = 779/4193 (18%), Positives = 1575/4193 (37%), Gaps = 632/4193 (15%)
Query: 1719 VSQKENTGQQNAIISPTVLETSEEKTVSLTVCS-AVKTEKTPQEKLR-----ESPGSEQT 1772
+SQ++ + I +V E ++ V + +CS A +T K QE + ES S T
Sbjct: 1558 LSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAIT 1617
Query: 1773 PFMTAPEGKGNGGVNPEPFRATQNVFT--------RQLCLEH--------DEKLVSYLSL 1816
F + N + A Q + RQ LE+ +++L S+L+
Sbjct: 1618 AFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTW 1677
Query: 1817 LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQI-IISQPQE 1875
L E + + D+ +E EL+ + L + E V+Q S+ +
Sbjct: 1678 LERGEAKASSPE---------MDISADRVKVEGELQLIQALQN---EVVSQASFYSKLLQ 1725
Query: 1876 VPAQLLKALEKD-AKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDL 1934
+ L KD K ++ L + + W + ++ V+ +H Q + L
Sbjct: 1726 LKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQS-VVAEHQQFDELLLSF 1784
Query: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEH 1994
W+ L L+ + SEI + + L +++D + +K +L +L H
Sbjct: 1785 SVWI---KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSL--------QGH 1833
Query: 1995 AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC 2054
L + L LL + E+ + V+ +Q+ L + LQ
Sbjct: 1834 LAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER-----RQLALSHLAEFLQS----- 1883
Query: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL--KDLQDDIQNRATSFATVV 2112
H L + Q R T + +++ KN+SDL KDL D +QN A + +
Sbjct: 1884 HASLSGIL------------RQLRQTVEATNSMNKNESDLIEKDLNDALQN-AKALESAA 1930
Query: 2113 KDIEGFMEENQTKL---SPRELTALREKLHQAKEQYEALQE------------------- 2150
++G + + Q L S + T+ R Q + E +Q
Sbjct: 1931 VSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAF 1990
Query: 2151 --------------ETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTS 2196
E R ++ L+E ALQQ + + +L + + L W+
Sbjct: 1991 QDQKEELLKSIEDIEERTDKERLKEPTRQALQQ---RLRVFNQLEDELNSHEHELCWLKD 2047
Query: 2197 VGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAP----EKLDKQCEMMKARHQ 2252
Q LE D T + NQ L ++ + +K+
Sbjct: 2048 KAKQIAQKDVAFAPEVDREINRLEV-TWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVS 2106
Query: 2253 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSE---AEL 2309
++L + I+ + + DQ + + + K+ ++ ++ + +EL
Sbjct: 2107 KVLENASSVIVTRTTIK---DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL 2163
Query: 2310 KQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVIS 2369
K++ + L K + + WL+ SEK ENM + L+ S +DV+S
Sbjct: 2164 KKIHSSDFSLVKTDME-STVDKWLDVSEKLEENMDR-----------LRVSLSIWDDVLS 2211
Query: 2370 HKGDLR-----FVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTR 2424
+ ++ V + + +++N + + E + VK+K R LHSK
Sbjct: 2212 TRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKAL----RLEELHSKVND 2267
Query: 2425 LGSHLNMLLGQYHQFQNSADSLQAWMQACEAN--VEKLLSDTVASDPGV---LQEQLATT 2479
L L AD +Q A E + L D A V + +
Sbjct: 2268 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2327
Query: 2480 KQLQEELAE--HQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537
+++E L E L+KV +DI + + QE +S+ + S
Sbjct: 2328 TKVEESLMNCAQNETCEALKKV-KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLG 2386
Query: 2538 RS--SLLQKAIAQSQ-------SVQESLES-LLQSIGEVEQNLEGKQVSSLSSG------ 2581
R+ L++K A SQ S+QESLE +S+ E ++ G + ++ S
Sbjct: 2387 RAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDS 2446
Query: 2582 -VIQEALATNMKLKQDIARQKSSLEA-TREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2639
V++ L + ++ +S L+A T+E T + + +++ Q ++ + ++ F+
Sbjct: 2447 KVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSI-QEQITKANEEFQA 2505
Query: 2640 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN--QPDQDITHFFQQIQ 2697
Q + + +L+ + FE KL ++ + N + Q I ++
Sbjct: 2506 FLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2565
Query: 2698 ELNL---EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKERE 2754
++ + E+ +E+LD L LS G Q L L + KE+
Sbjct: 2566 KVEMFLGELLAARESLDKLSQRGQLLSEEGHGAG--QEGRLCSQLLTSHQNLLRMTKEKL 2623
Query: 2755 KDASSCQEQLDEFRKLVRTFQK---WLKETEGSIPPTETSMSAKE-LEKQIEHLKSLLDD 2810
+ SCQ L E L Q W+K + + E+++ +K+ LEK++ ++ +L
Sbjct: 2624 R---SCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL-- 2678
Query: 2811 WASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEI 2870
KG L M I GK L S + G + L E+
Sbjct: 2679 -----------LMKGEGEVKLNMAI------GKGEQALRS-SNKEGQRVIQTQLETLKEV 2720
Query: 2871 QCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMS 2930
D+ ++ Q +L++++++ + + N + QW+ES ++ ++
Sbjct: 2721 WADIMSSSV----------HAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQ 2770
Query: 2931 SPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELN 2990
K + V + ++ L+E E ++ + ++ +A Y +++ QEEL
Sbjct: 2771 PGLKEKFVLL--DHLQSILSEAEDHTRALHRL---IAKSRELYEKTEDESFKDTAQEELK 2825
Query: 2991 SRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNA 3050
+++ V + R++EE + A + WL + + +S D +
Sbjct: 2826 TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQK 2885
Query: 3051 QKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVEL 3107
+ +++ ++ E +R + E L + T G + T E+Q++ W +
Sbjct: 2886 KLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHT-----EMQALRADWKQW 2940
Query: 3108 TDKLNSRSSQIDQAIVKST-----------QYQELLQDLSEKVRAVGQRLSVQSAISTQP 3156
D + S ++ + + Q ++ L+ S ++ Q+L++ +T
Sbjct: 2941 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 3000
Query: 3157 EAVK------------QQLE-ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDEL 3203
E V+ Q+ E T +++S L +L ++ T ++S LI E
Sbjct: 3001 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYN----- 3055
Query: 3204 KKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPIS 3263
L LQ + N+ Q Q+F++ F + + WL + + AK I
Sbjct: 3056 -------CLCLQASKGCQ----NKEQIL---QQRFRKAFRDFQQWLVNAKITTAKCFDIP 3101
Query: 3264 AKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNH 3323
+ + + LQ+ +EF +++++GE LL ++ E+ + +Q ++ K
Sbjct: 3102 QNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE-LLSTLLTKEKAKGIQAKVTAAKED 3160
Query: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-DPVQLESSL 3382
W+ ++S L++ + + ++ E + W+ + + E L D
Sbjct: 3161 WKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ 3220
Query: 3383 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKT 3442
+ +++L E+ L L A L A + R + ++ A++ + K
Sbjct: 3221 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS-FRHRVSQLSSQYLALSNLTKEKV 3279
Query: 3443 GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF-DALGSQACSNKNLEKLRAQQEVLQA 3501
L+ + +F K ++ + A H L+ + ++ + KL A V Q
Sbjct: 3280 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3339
Query: 3502 LEPQVDYLRNFTQGLVED-APDGSDASQLLHQAEVAQQEFLEVKQR---VNSGCVMMENK 3557
E Q+ + + ++++ +P+G QQ+ VK + S + +++
Sbjct: 3340 KEIQMKMIVTRGESVLQNTSPEG---------IPTIQQQLQSVKDMWASLLSAGIRCKSQ 3390
Query: 3558 LEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDI- 3616
LEG ++ Q + +D M A +++ +++ D L K +L ++
Sbjct: 3391 LEGALSKWTSYQDGVRQFSGW---MDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVL 3447
Query: 3617 ------EASEAECRHMLEEEGT-LDLLGLKRELEALNKQCG-------KLTERGKARQEQ 3662
E E + M E T L+L L+ A+ ++ KL + Q
Sbjct: 3448 SYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3507
Query: 3663 L---ELTLGRVE---DFYRKLKGLNDATT--------------AAEEAEALQWVVGTEVE 3702
L E+ LG+ + D Y L+G DA T AE L V+ T +
Sbjct: 3508 LKAFEVWLGQEQEKLDQYSVLEG--DAHTHETTLRDLQELQVHCAEGQALLNSVLHTRED 3565
Query: 3703 IINQQLA------------DFKMFQ----------KEQVDPLQMKLQQVNGLGQGLIQSA 3740
+I + D++ +Q V+ L++ Q+ + + L +
Sbjct: 3566 VIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAE 3625
Query: 3741 GKDC--DVQGLEHDMEEINAR------------------------WNTLNKKVAQRIAQL 3774
K +V ++EE+ AR + L +V ++I L
Sbjct: 3626 EKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFL 3685
Query: 3775 QEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDR 3832
+E + + + +L W T + N K + + V + +KL L+ LL D
Sbjct: 3686 EEEIQSLEESESSLSSYSDWYGSTHK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDM 3742
Query: 3833 KATVDMLQA---EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVL 3889
+ +L++ +G R + E + E++ ++ + EL S LE L L
Sbjct: 3743 EKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHL 3802
Query: 3890 AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAV 3949
AK+F + + ++ +++ ++ L E + + + Q+ ++K+L++ + +H V
Sbjct: 3803 AKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVR 3862
Query: 3950 KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEV 4009
+ G++L L L +KID LQ+ Y QD C A++++
Sbjct: 3863 EKGEALLELVQDV---TLKDKIDQLQSDY---QDLCSIGKAMMEE--------------- 3901
Query: 4010 LNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTT 4069
+A ED+L+++ K D L Q ADHL QA LKQ
Sbjct: 3902 ---IAGFEDRLNNL---QMKGDTLIGQCADHL--------------------QAKLKQN- 3934
Query: 4070 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL 4129
+ L G K Y+ I T+ + ++LE Q Q T ++ WL V+ +L
Sbjct: 3935 ------VHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 3988
Query: 4130 ATSGGQSPTG-----EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREG 4184
S Q P +Q+ F+ Q++ + + + D N + + + +
Sbjct: 3989 EPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTI 4047
Query: 4185 LDKLVSDAN-----EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA--WVAETKRK 4237
KLV N E+ K + + + + D +Q ++ + +A V++ K
Sbjct: 4048 EQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4107
Query: 4238 LMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK 4297
+ +L+ Q + ++K + E+ + C + LQ +
Sbjct: 4108 VK-----KLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE 4162
Query: 4298 TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL-IAQLPSPAID 4356
E L + + +N +V + +F ++ L+ E+ A+ + L A+
Sbjct: 4163 -EDLQRTRDYHDCMNV--------VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALA 4213
Query: 4357 HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQI 4416
++ + E+++ ++ + EH LN ++ E+V+E+ E + Q+
Sbjct: 4214 LQERKYAIEDLKDQKQKMIEH----------------LNLDDKELVKEQTSHLEQRWFQL 4257
Query: 4417 KEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE----NLSSRLRMPPLIPAEVDKIR 4472
++ ++++ + +V+ ++ + + ++E E N++ L+ P D +
Sbjct: 4258 EDLIKRK---IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP----PPDMAQ 4310
Query: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
+ D+ + ELE Q ++L + + ++ ++ + K + D + + +
Sbjct: 4311 NLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLV 4370
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEA 4590
R K+L+ L+EK + MA T I+ + + E + P + +QV+
Sbjct: 4371 GQRR-----KYLNKA-LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKT 4424
Query: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE 4650
++ + E+ + G +L+ E EK EV + E+ + ++++ + RL+
Sbjct: 4425 CKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQ 4484
Query: 4651 KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQ 4710
+LE + + +++ WL I T P + +N + ++ +++ + +Q
Sbjct: 4485 ELEKNLVSRKHFKEDFDKACHWLKQADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQ 4540
Query: 4711 QIEMEKL----NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGAL 4766
E E L G+ +L + +E D + E L L + + + +K++ A+
Sbjct: 4541 SPEYENLLLTLQRTGQTILP-SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAI 4599
Query: 4767 LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVET 4826
LA ++ +E LT T+ L + +E + + + D+ +A +
Sbjct: 4600 LARKEYASLIE-----LT-TQSLSE-----------LEAQFLRMSKVPTDLAVEEAL--S 4640
Query: 4827 VNKAGNELLESSAG-----DDASSLRSRLEAMNQCWE--------SVLQKTEEREQQLQS 4873
+ +L+ AG D+ + + + Q W+ ++ + + + +Q S
Sbjct: 4641 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVS 4700
Query: 4874 TLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETY 4933
L+ + E E +L R QL + K + +++Y L +
Sbjct: 4701 LLEDTTSAYQEHEKMCQQLER---QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDS 4757
Query: 4934 NQLLDKGRLML---LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATE 4990
+L + + L D + K + + + +++S + E ++ E + + +
Sbjct: 4758 GIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID 4817
Query: 4991 FQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTG 5050
FQ + ++WL + L+ L L + +I + ++ EV + + L
Sbjct: 4818 FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKE 4877
Query: 5051 NQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLID 5109
+ KF K+ + ++ S + +Q ++ R +L + + +++++ ++ D
Sbjct: 4878 KE-KFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAAND 4936
Query: 5110 WLEDA----------------ESHLDSELEISNDPDKIKLQLSKHKEFQKTLG------G 5147
WLEDA E +L S +E + D+ L + TL G
Sbjct: 4937 WLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTG 4996
Query: 5148 K----QPVYDTTIRTGRALKEK----------TLLPEDSQK----LDNFLGEVRDKWDTV 5189
K Q V +R+ R ++ T D QK + + + K
Sbjct: 4997 KEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEF 5056
Query: 5190 CGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHK 5249
H+ EE L + + + + + +E + ++ + D
Sbjct: 5057 SLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTT 5116
Query: 5250 VFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRL 5308
V+Q R ++ + + +++E++ D+ T ++++ + D + KL S +
Sbjct: 5117 VWQ-----RWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKA 5171
Query: 5309 EQA-LKQAEVFRDTVHMLLEWLSEA-----EQTLRFR--GALPDDTEA--LQSLIDTHKE 5358
+A L + DT + LE A +QTL GA P E L I ++
Sbjct: 5172 SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQD 5231
Query: 5359 FMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWI----------TI-IRARFEEV- 5406
++EK V N + E+ I ++K W+ TI I A+ EE+
Sbjct: 5232 RCLNMQEK-VKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQ 5290
Query: 5407 --LTWAKQHQQRLETALSELVANAELLEELLAW---IQWAETTLIQRDQEPIPQNIDRVK 5461
LT A H+Q +E E L +L +Q AE L + ++ I I V+
Sbjct: 5291 ILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVE 5350
Query: 5462 ALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTP 5517
A Q ++ + D+ + K K A +K G L +
Sbjct: 5351 QSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDA 5410
Query: 5518 PPMPILSQS----EAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566
L Q+ + +I +L+ QQ A R KLN A LEE E
Sbjct: 5411 AVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNE 5463
Score = 261 bits (668), Expect = 1e-68
Identities = 661/3434 (19%), Positives = 1372/3434 (39%), Gaps = 384/3434 (11%)
Query: 1805 EHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAK----VLERELKDLTTLVSQ 1860
E ++ + L R I+ K + + L D + QAK VL EL + +
Sbjct: 5348 EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKL-M 5406
Query: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWN------SRLLHFQNAVE 1914
EL+ Q + Q ++ L K + K + Q+++ + + S L + +E
Sbjct: 5407 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 5466
Query: 1915 -----IEKTKVLNQHTQLEGRLQDLRA-WVGNKNLILNSKGSNSEIDVDSLNLCLQQYED 1968
IEK KVL T LR ++ ++ L+ SK +SE++ + L
Sbjct: 5467 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 5526
Query: 1969 LKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQV 2028
+ M+++ A+L +++ I Q+L + M + EL++ Q LEQ A +
Sbjct: 5527 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA-KDMKKFEAELKK-LQAALEQAQATL 5584
Query: 2029 DALQ-GHLQQMEQEALVKTLQKQQNTCHQQLE--DLC-SWVGQAERALAG----HQGRTT 2080
+ + G L EQ + + L + + +++ LC S + E +A H
Sbjct: 5585 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRL 5644
Query: 2081 QQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL-TALREKLH 2139
Q++ S LQ ++ + + +K ++ +E ++ + + T+ ++L
Sbjct: 5645 QEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQ 5704
Query: 2140 QAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA---------KELAENKKKIDAL 2190
++E L ++ + Q+++ ++ S + T K+K A + LAE + +D
Sbjct: 5705 AQISRHEELAQKIKGYQEQIA-SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGE 5763
Query: 2191 LDWVTSVGSS-----GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCE 2245
L S S G+ T L + + SG + + + D
Sbjct: 5764 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANT-DASVN 5822
Query: 2246 MMKARHQELLSQQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 2300
A +Q L +++ A T ++Q F + P + KLG+L+ + T
Sbjct: 5823 QDIAYYQALSAERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWET 5875
Query: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360
+ + + + QK+ + + +E E +L + G SPE S +
Sbjct: 5876 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEH 5932
Query: 2361 GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHS 2420
+ ++++ + ++ + S + L E+ + E + + L ER + +
Sbjct: 5933 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRM 5988
Query: 2421 KCTR----LGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPG 2470
K + L LN L + Q ++ AD L +W+ + +A ++ LS +P
Sbjct: 5989 KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPM 6046
Query: 2471 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2530
++ QL + + E+ + V + +L V + + +EG+ H ++ + + +
Sbjct: 6047 DMEAQLMDCQNMLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRR 6100
Query: 2531 LSYSLAE-RSSLLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQ 2584
L SL E + +L K + + QE ES QS G E + + + Q
Sbjct: 6101 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---Q 6157
Query: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQ 2644
+L +L+Q++A QKS L R + +R E +AA G E Q +
Sbjct: 6158 SSLQQQKELEQELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
Query: 2645 QEKESSLKKLLPQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPD 2686
EK S+ ++ + E + + S K LQ +E + L G+ P
Sbjct: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
Query: 2687 QDITHFFQQIQELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2738
QD + + LN E+ +++++ + L +S+ LD + + V
Sbjct: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
Query: 2739 -LRKDFTELQKTVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------ 2783
L + TE +E KD E++D+ + L + +++T G
Sbjct: 6335 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6394
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAP 2838
S+ + + +++++++ + + +D T + + + E + E
Sbjct: 6395 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEA 6454
Query: 2839 DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898
Q + G G G + +Q ++S + Y++L ++ R+ L
Sbjct: 6455 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQN 6513
Query: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958
L + + + LE+ +E + + +K E ++ + +K + LE +
Sbjct: 6514 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH--- 6569
Query: 2959 IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQ 3018
+ E L ++++ +E + ++ + ++ +RA + V + LE + SHL
Sbjct: 6570 -MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---D 6624
Query: 3019 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 3078
+ +L L E + +G + + + L + Q + + + Q+ + +
Sbjct: 6625 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6684
Query: 3079 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 3138
+L +S+S S ++ +L + + W+ T+K++ +++ + T+YQ DL
Sbjct: 6685 LL-----ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 6739
Query: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
+++ RL + Q V Q+LE + + + EV +AQ+ + G Q
Sbjct: 6740 LQSAKDRLEFWTQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQL 6795
Query: 3199 LKDELKKRLETVAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWL 3249
L+ K+++T L L ++ D + + A Q Q E+ +W+
Sbjct: 6796 LR---LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 6852
Query: 3250 DDKQSQQAK---NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVP 3305
++ K N S + + LQ+ + F+ +N + + + +S+L +S
Sbjct: 6853 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQ 6909
Query: 3306 PGEEKRT----LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
E KR+ QL + W+ L ++ L+ ++ +Y+ +V+ L W E
Sbjct: 6910 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 6969
Query: 3362 CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIR 3421
+ ++ + D ++++L + + + ++ + +E + LI + + D I
Sbjct: 6970 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI- 7028
Query: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 3481
+ + EL +L+ M +L+ +S + + + H++ FD + S
Sbjct: 7029 ---------VMSTLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINS 7073
Query: 3482 QACSNK-NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVA 3536
+ +L + R L+A++ QVD L+N L + GS +QLL +
Sbjct: 7074 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 7133
Query: 3537 QQEFL-----EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRD 3591
E L EV R N+ ++E E + Q + +++ + D +
Sbjct: 7134 VTETLTNTLKEVNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQ 7179
Query: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEAL 3645
S Q ED L K K DI E +C +L+ GT+ D L EL
Sbjct: 7180 CASTVQQQEDRTNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7238
Query: 3646 NKQCGKLTERGKARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVV 3697
KQ + + +QL L+ L +E K + G+ D T A+ EAL+ W+V
Sbjct: 7239 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7298
Query: 3698 GTEVEIINQQ----LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE- 3750
E EI+ Q +D Q E+++ L+ ++ + + + L + G + E
Sbjct: 7299 EAE-EILQGQDPSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7356
Query: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810
M+ +N W+ ++ + +R ++LQ LL F + E + +L TE+ +A + S
Sbjct: 7357 KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SG 7414
Query: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT 3870
Y+ + Q + +L Q + R+ + + +G R+ + ++ DR++ +L L ++W
Sbjct: 7415 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 7474
Query: 3871 ELLSKAAARQKQLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQ 3927
++ +A R+ ++ + +++ E AE + +L S S P+ Q A+
Sbjct: 7475 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 7534
Query: 3928 IIRHKALEEDIENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC 3986
++ K E+ V+ G Q L S S AE +LQA +EIQ++
Sbjct: 7535 EVQFK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWK 7584
Query: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046
+ L++ +D + +A+ +KL + FK+ + H L+ E
Sbjct: 7585 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAE 7639
Query: 4047 IVNRKKNVDQAIKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSS 4095
+ R K ++ A+ + +LLK T + +++ ++ E+++ ++ ++ ++ S
Sbjct: 7640 QM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698
Query: 4096 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155
+ + + F +EL WL ++E +++ +G E I + ++ +E
Sbjct: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAI 7757
Query: 4156 VMEHRLVLDTVNE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
E+++ L + E +++A E +A E ++ + N++++ + D I RV ++ +
Sbjct: 7758 AQENKIQLQQMGERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
Query: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDS 4271
QQ ++ + W+A + +L PI + ++ +L Q+ DI +H
Sbjct: 7814 VAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
Query: 4272 MDELFSHRSEIFGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 4327
+ + + + C + + +Q+ T +L +++ I ++ ER ++E L
Sbjct: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
Query: 4328 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387
+F + Y W++ + A S + + +++ ++ + + E ++ + K
Sbjct: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
Query: 4388 GPQLKELNPEEG-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
+L N + +MV E Q+ +N+ ++ +R+ L + Q + D
Sbjct: 7992 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARD 8047
Query: 4443 KIEPMLETLENLSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKR 4497
I L ++ L ++ EC I K+ E+ E +
Sbjct: 8048 SILVWLTEMD----------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 8097
Query: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------E 4538
+GE+LI +S+ D A I+++LD++ + +++ R E +
Sbjct: 8098 QGEQLIEKSEPLD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 8153
Query: 4539 REIKFLDVLELAEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4597
RE++ D L++ W+D +A L + + + ++ L P + + ++I E
Sbjct: 8154 RELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE 8213
Query: 4598 TD---GLHEELEFIRILGADLIFACGETEKPEVRKS--------IDEMNNAW----ENLN 4642
D L +LE G+ +K + I E A+ EN
Sbjct: 8214 WDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAI 8273
Query: 4643 KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPPVGTDLNTVKDQLNEMK 4701
K LE ++ + D + +N + K T P + T L E
Sbjct: 8274 KNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECS 8333
Query: 4702 EF--KVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
V+ + +++ E+ + G + L +T I R WE L + ++
Sbjct: 8334 SSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKE 8384
Query: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDV 4817
+++ L QF L + +WL TEE L+ + +S D + IE+++ K L+ V
Sbjct: 8385 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8444
Query: 4818 LAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4877
+A + ++N E ++ + ++ L+ RL MN W+ V EE LQ L Q
Sbjct: 8445 DHRKAIILSINLCSPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8503
Query: 4878 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL 4937
QGFH LL L ++ + + P E L H + Q+K ++LL
Sbjct: 8504 CQGFHEMSHGLLLMLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELL 8555
Query: 4938 DKGRLMLLSRDDSGSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQ 4992
+ + +D S + LE +K HV+ ++++ + S+ + L +
Sbjct: 8556 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS 8615
Query: 4993 NSLQEFINWLTLAE 5006
+S Q+ +W + E
Sbjct: 8616 SSQQDLSSWSSADE 8629
Score = 255 bits (652), Expect = 8e-67
Identities = 653/3806 (17%), Positives = 1451/3806 (38%), Gaps = 482/3806 (12%)
Query: 1953 EIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNE 2012
E+ ++ L +Q ED++Q + AQ + E Q+ + ++M +++
Sbjct: 743 EVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE----EGKEMFATMSK 798
Query: 2013 LQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAER-A 2071
L+ + E + + Q L +E+ L+KQ + + L + + ER A
Sbjct: 799 LKEQLTKVKECYSPLLYESQQLLIPLEE------LEKQMTSFYDSLGKINEIITVLEREA 852
Query: 2072 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 2131
+ + Q+L A Q+N L + F T+ ++ F +
Sbjct: 853 QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHF-----------DQ 901
Query: 2132 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA--------AKELAEN 2183
T L+ ++ ++++ ++T +K +E S L ++ E+S+A A+E E
Sbjct: 902 TRLQRQIADIHVAFQSMVKKTGDWKKHVE--TNSRLMKKFEESRAELEKVLRIAQEGLEE 959
Query: 2184 KKKIDALLDWVTSVGSSGGQLLTN--LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 2241
K + LL T S Q + N L ++L+ E+ G+ +A KL
Sbjct: 960 KGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQ-------QGLQEAVRKLH 1012
Query: 2242 KQ------------------------------CEMMKARHQELLSQQQNFILATQSAQAF 2271
KQ C R +L+ Q+ + + + F
Sbjct: 1013 KQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFF 1072
Query: 2272 LDQHGHNLTPEEQQMLQQKLGEL--KEQYSTSLAQSEAELKQVQTLQDEL-QKFLQD--- 2325
D+ H+L + Q++++ +L ++ + LK+++ D +K ++D
Sbjct: 1073 SDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK 1132
Query: 2326 -------HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVT 2378
EF SW+ +E +L+ + KG + +KR + ++ +G+
Sbjct: 1133 WKDYTSRFSEFSSWISTNETQLKGI-KGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL 1191
Query: 2379 ISGQKVLDMENSFKEG-KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYH 2437
S KVL +S E K+ E+ KL + + L S+ ++ S+ +
Sbjct: 1192 KSRLKVLTEVSSENEAQKQGDELA-----KLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1246
Query: 2438 QFQNSADSLQAWMQACEANVEKLL-SDTVASDPGVLQEQLATTKQL-------QEELAEH 2489
+NS + L + + + EK+L ++ + +L TK++ Q+++A+
Sbjct: 1247 IVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQA 1306
Query: 2490 Q-----VP---VEKLQKVARDIMEIEGEPAPDHRHVQ---------ETTDSIL------- 2525
Q +P E+L+K+ + +E R +Q ET +
Sbjct: 1307 QQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQT 1366
Query: 2526 --SHFQSLSY-SLAERSSLLQKA---IAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLS 2579
SH + LS+ SL SS L++ +++S+ E+L++ E+ + KQ+
Sbjct: 1367 GSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQ 1426
Query: 2580 SGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV---------LQGKL 2630
+ I+E + KL+ + ++E + F ++ + + L+
Sbjct: 1427 AKSIKEQV---KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSS 1483
Query: 2631 AEVSQRFEQLCLQQQEKESSLKKLL---PQAEMF---------EHLSGKLQQFMENKSRM 2678
+ + + Q+ + QE ES L ++ +A+ F + KL Q +
Sbjct: 1484 SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEEL 1543
Query: 2679 LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLE-HLVTELSSCGFA----------L 2727
+ I Q Q+ + Q+++ E L + C A +
Sbjct: 1544 REHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHM 1603
Query: 2728 DLCQHQDRVQNLRKDFTELQKTVKERE---KDASSCQEQLDEFRKLVRTFQKWLKETEGS 2784
DLCQ + + + F+ + V R+ ++A++ Q+Q ++ + + Q L+
Sbjct: 1604 DLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALE----- 1658
Query: 2785 IPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVE-EINCKGTSLENLIMEITAPD---- 2839
+ LEK++ + L+ +K + E +I+ +E + I A
Sbjct: 1659 ----NLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
Query: 2840 SQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAIL 2899
SQ S L + S+ SV + D+ ++ + ++ ++ L ++++R LQ+++
Sbjct: 1715 SQASFYSKLLQLKESLFSV---ASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVV 1771
Query: 2900 NRMEEVHKEANSVLQWLE------SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2953
++ + S W++ + MD + T+ + A+ ES K L L+
Sbjct: 1772 AEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQ 1831
Query: 2954 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 3013
+ K+ + A ++ + E+ +E A++V RQ L SH
Sbjct: 1832 GHLAKLGSLGRA-----------EDLHLLQGKAEDCFQLFEEASQVVERRQLAL----SH 1876
Query: 3014 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNA-QKQQVQFMLKEFEARRQQHEQL 3072
LA F + + L G+L L N+ K + + K+ Q + L
Sbjct: 1877 LAEFLQSHASL----------SGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKAL 1926
Query: 3073 NEAAQGILTGPGDVSLSTSQVQKELQSINQKW-------------VELTDKLNSRSSQID 3119
AA + D LS +Q ++ S Q+ + + L ++ S+ D
Sbjct: 1927 ESAAVSL-----DGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD 1981
Query: 3120 QAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHE 3179
V +Q+ ++L + + + +R + +A++Q+L +++ +L +HE
Sbjct: 1982 ALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHE 2041
Query: 3180 VKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQ 3239
+ + +++ + E+ + + + + + L + + + +++Q
Sbjct: 2042 LCWLKDKAKQIAQ--KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQ 2099
Query: 3240 QMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGES 3299
+ + L++ S I + E L+ ++E + +N + ++G+
Sbjct: 2100 NLKSAVSKVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKH 2158
Query: 3300 LL--LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVP 3357
LL L + ++ + + W ++S+K + RL+ + +++
Sbjct: 2159 LLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEG 2218
Query: 3358 WIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL--INSSEA 3415
W +C +M+E LD LL K +EV+ + LE L+S + L + +
Sbjct: 2219 WSNNCVPQMAENISNLDNHLRAEELL--KEFESEVKNKALRLEELHSKVNDLKELTKNLE 2276
Query: 3416 DEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI 3475
++ +A + Q ++ E + G+L++ T + + ++ +I + L
Sbjct: 2277 TPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-- 2334
Query: 3476 FDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEV 3535
N+ E L+ +++ + L+ Q + + + L + + H AE+
Sbjct: 2335 -----MNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL-------NSLCRKYHSAEL 2382
Query: 3536 -----AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGR 3590
A ++ + V+ C + L+ + H Q L + + R
Sbjct: 2383 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDR 2442
Query: 3591 DTDS--LQSQIEDVRLFLNKIH--VLKLDIEASE-----AECRHMLEEEGTLDLLGLKRE 3641
DS L++++ D++ L+ + KLD E A + + E
Sbjct: 2443 TGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEE 2502
Query: 3642 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLK----GLNDATTAAEEAEALQWV- 3696
+A KQC K K + LG ED +RKL + + E+ Q +
Sbjct: 2503 FQAFLKQCLK----DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIP 2558
Query: 3697 -VGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3755
EV + L + + +E +D L + Q ++ G G Q G+ C H
Sbjct: 2559 EKKNEVHKVEMFLGEL-LAARESLDKLSQRGQLLSEEGHGAGQE-GRLCSQLLTSH---- 2612
Query: 3756 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3815
L + +++ Q AL ++AL+ + W+ ++ +A + +
Sbjct: 2613 -----QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTL 2667
Query: 3816 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3875
+ ++ + + + + + + ++M +G + +S+ + I QLE+L+ W +++S
Sbjct: 2668 EKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSS 2727
Query: 3876 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQII--RHKA 3933
+ Q LE ++ + E + ++ ++K+ P+ Q ++ ++ ++
Sbjct: 2728 SVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI--EHPLQPQPGLKEKFVLLDHLQS 2785
Query: 3934 LEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLD 3993
+ + E+H +H+ + + L T ++ + L+ ++++I K ++
Sbjct: 2786 ILSEAEDHTRALHRLIAKSRELYEKTE--DESFKDTAQEELKTQFNDIMTVAKEKMRKVE 2843
Query: 3994 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 4053
+ + + ++ + E +WL +++L D D Q L+ +E+++ ++
Sbjct: 2844 EIVKDHLMYLDAVHEFTDWLHSAKEELHR--WSDMSGDSSATQ--KKLSKIKELIDSREI 2899
Query: 4054 VDQAIKNGQALL----KQTTGEEVLLIQEKLDGIK------------TRYADITVTSSKA 4097
+ ++L + TT L+ ++ ++ T+ + S A
Sbjct: 2900 GASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA 2959
Query: 4098 LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE----LK 4153
L E + Q+A + + E+ + L+ ++L G++ T E+I + + +E L+
Sbjct: 2960 LSEQEFSGQVA-QLEQALEQFSALLKTWAQQLTLLEGKN-TDEEIVECWHKGQEILDALQ 3017
Query: 4154 KEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAA 4213
K + +NE+ R +L + + VS ++Y + + +
Sbjct: 3018 KAEPRTEDLKSQLNELCRFSRDLSTYSGK------VSGLIKEYNCLCLQASKGCQNKEQI 3071
Query: 4214 IQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMD 4273
+Q Q++ +A W+ K I + + LQ + F + + ++
Sbjct: 3072 LQ--QRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLN 3129
Query: 4274 ELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
+ S + +E+ +Q K + + ++ ++ + LE ++ + F +
Sbjct: 3130 MMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSA 3189
Query: 4334 EELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE 4393
E + W+ +T ++ + + D R++Q++++ + E I ++P +++L + QL E
Sbjct: 3190 EPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE 3249
Query: 4394 LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ----ITEFHDKIEPMLE 4449
+ + + + Y + +++ LD V++ Q I E D + +
Sbjct: 3250 -GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3308
Query: 4450 TLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGA 4509
L++ ++ + K+ +S + +++ + + RGE ++ +
Sbjct: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQM-------KMIVTRGESVLQNTSPE 3361
Query: 4510 DKDLAAKEIQDKLDQMVFFWEDI-------KARAEEREIKFLDVLELAEKFWYDMAALLT 4562
IQ +L + W + K++ E K+ + +F M ++
Sbjct: 3362 ----GIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEA 3417
Query: 4563 TIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGET 4622
+ +++ +L + A+ + EE LE I + GA G T
Sbjct: 3418 NLNESERQHAELRDK-------TTMLGKAKLLNEEVLSYSSLLETIEVKGA------GMT 3464
Query: 4623 EKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT 4682
E + + ++ + + + KE + K E ++ +YQ L+A WL KL
Sbjct: 3465 EHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ 3524
Query: 4683 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLT 4742
+ D +T + L +++E +V + Q + + H E ++ + + L
Sbjct: 3525 YSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE----DRALE 3580
Query: 4743 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV 4802
L+ W+ +++ + + + L + +++ WL EE
Sbjct: 3581 SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-------------- 3626
Query: 4803 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESS-----AGDDASSLRSRLEAM---- 4853
K H +V A++ VE V E+L+ S G A+ L SR +A+
Sbjct: 3627 -----KKWH---EEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQV 3678
Query: 4854 ---NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPE 4910
+ E +Q EE E L S H ++ ++ ++++ + K E
Sbjct: 3679 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLK--TLE 3736
Query: 4911 TAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVV 4970
+ ++ L + K E + L++G L ++ +EQ +
Sbjct: 3737 VLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDH----------MEQLKELT 3786
Query: 4971 SSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHK 5030
S+ +E + LE+ L+LA EF + + W+ ++ L++ P + L +Q+ ++K
Sbjct: 3787 STVRKEHMT-LEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYK 3845
Query: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
V +H + + + G L L QDV L K+ + +QS ++ + +
Sbjct: 3846 SLQQTVLSHEPSVKSVREKGEAL--LELVQDVTL-KDKIDQLQSDYQDLCSIGKAMMEEI 3902
Query: 5091 DDARKRAKQFHEAWKKLIDWLED---------AESHL----DSELEISNDPDK----IKL 5133
R LI D +HL DS I + + ++
Sbjct: 3903 AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH 3962
Query: 5134 QLSKHKEFQKTLGGKQ-----------PVYDTTIRTGRALKEK---TLLPEDSQKLDNFL 5179
+L KH Q TL Q P + A+K+ L E ++ + L
Sbjct: 3963 ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLL 4022
Query: 5180 GEVRDKWDT---VCGKSVERQHKLEEALLFSGQFM----DALQALVD--WLY--KVEPQL 5228
+ D + K +++ + E L Q + + ++ L W+Y + QL
Sbjct: 4023 CSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQL 4082
Query: 5229 AEDQPVHGDLDL--VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQ 5286
+ H +L+L N++ K F K+L + +V + +L ++ + + +
Sbjct: 4083 QNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL---TKKEESPEHKE 4139
Query: 5287 LQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT 5346
+ L+ +W +C+ S + + E+ L++ + D ++++ +L + T + D
Sbjct: 4140 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKF--TTEWDNLARSDA 4197
Query: 5347 EALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV 5406
E+ ++ K+ ++E++ + + ++ + D +K + + R+ ++
Sbjct: 4198 ESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL 4257
Query: 5407 LTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQR-DQEPIPQNIDRVKALIA 5465
K+ Q T L EL +EL+ W + + + + Q P P D + L+
Sbjct: 4258 EDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPP---DMAQNLLM 4314
Query: 5466 EHQTFMEEMTRKQ-------PDVDRV 5484
+H E+ KQ D DRV
Sbjct: 4315 DHLAICSELEAKQMLLKSLIKDADRV 4340
Score = 226 bits (576), Expect = 5e-58
Identities = 731/4046 (18%), Positives = 1559/4046 (38%), Gaps = 550/4046 (13%)
Query: 1836 ELQDLLCQAKVLERELKDLTTLVSQELECVNQI--IISQPQEVPAQLLKALEKDAKNLQK 1893
E D +KVLE +L DL ++ + +++ + + Q + A L K + ++Q+
Sbjct: 2438 ESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQI---VSSIQE 2494
Query: 1894 SLSSVSDTWNSRL---LHFQNAVE---IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNS 1947
++ ++ + + L L + A++ E +QH +L + ++ +NL
Sbjct: 2495 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENL---- 2550
Query: 1948 KGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEH----------AQD 1997
G + + + N + L + +A R++ LD L+ Q E +Q
Sbjct: 2551 -GESKQHIPEKKNEVHKVEMFLGELLAARES-LDKLSQRGQLLSEEGHGAGQEGRLCSQL 2608
Query: 1998 LSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG------HLQQM---------EQEA 2042
L+ QN +LR+ E RS Q L++ A +ALQ +Q ++
Sbjct: 2609 LTSHQN--LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDT 2666
Query: 2043 LVKTLQKQQNTCHQQLE---DLCSWVGQAERAL--AGHQG-RTTQQDLSALQKNQSDLKD 2096
L K L + Q+ + E L +G+ E+AL + +G R Q L L++ +D+
Sbjct: 2667 LEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMS 2726
Query: 2097 LQDDIQNRATSFATVVKD-------IEGFMEENQTK----LSPR---------------- 2129
Q+ S + D +E +ME K L P+
Sbjct: 2727 SSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSI 2786
Query: 2130 ------ELTALREKLHQAKEQYEALQEET--RVAQKELEEAVTSALQQETEKSKAAKELA 2181
AL + +++E YE ++E+ AQ+EL+ + EK + +E+
Sbjct: 2787 LSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIV 2846
Query: 2182 -ENKKKIDALLDWVTSVGSSGGQL--LTNLPGMEQLSGASLEKGALDTTDGYMGVNQ--- 2235
++ +DA+ ++ + S+ +L +++ G + L K +G ++
Sbjct: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSR 2906
Query: 2236 ----APEKLDKQ----CEMMKARHQELLS---QQQNFILATQSAQAFLDQHGHNLTPEEQ 2284
APE CE+M Q L + Q ++ + TQS E
Sbjct: 2907 VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCL-------------EN 2953
Query: 2285 QMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFL-------QDHKEFESWLERSE 2337
+ Q L E +++S +AQ E L+Q L + L D + E W + +
Sbjct: 2954 LVSQMALSE--QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECW-HKGQ 3010
Query: 2338 KELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP 2397
+ L+ + K E L S L FS D+ ++ G
Sbjct: 3011 EILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSG------------------------- 3045
Query: 2398 SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANV 2457
++ L+K+ Y L + ++ + +L Q +F+ + Q W+ +
Sbjct: 3046 -KVSGLIKE--------YNCLCLQASKGCQNKEQILQQ--RFRKAFRDFQQWLVNAKITT 3094
Query: 2458 EKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGE------PA 2511
K P + E + +++QE L+E + KL ++M +GE
Sbjct: 3095 AKCF-----DIPQNISEVSTSLQKIQEFLSESENGQHKL-----NMMLSKGELLSTLLTK 3144
Query: 2512 PDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLE 2571
+ +Q + +++ +L ++ S L+ Q + + S E + + + E
Sbjct: 3145 EKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTE---- 3200
Query: 2572 GKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETAD-----STTAAVL 2626
K V S+ + L + +Q + + + R E A +
Sbjct: 3201 -KMVHESSNRLYD--LPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSF 3257
Query: 2627 QGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD 2686
+ +++++S ++ L +EK S L +++ + F +LQ +M + ML S P
Sbjct: 3258 RHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPT 3317
Query: 2687 QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC---GFALDLCQHQDRVQNLRKDF 2743
D + + +L + +QE ++ +VT S + Q ++Q+++ +
Sbjct: 3318 SDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMW 3377
Query: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIE 2802
L + + ++ VR F W+ E ++ +E ++ +
Sbjct: 3378 ASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLG 3437
Query: 2803 HLKSLLDDWASKGTLVEEINCKGTSL-ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGY 2861
K L ++ S +L+E I KG + E+ + ++ D Q + +I +V
Sbjct: 3438 KAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAV--TKSE 3495
Query: 2862 HTCKDLTEIQCDMSDVNL----------KYEKLGGVLHERQESLQAILNRMEEVHKEANS 2911
+ E Q D+ + +Y L G H + +L+ L ++ E +
Sbjct: 3496 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRD-LQELQVHCAEGQA 3554
Query: 2912 VL-QWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLL 2970
+L L ++E+V+ S + E+++ ++ + L+E + + L
Sbjct: 3555 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR------TQFNNVVNKLR 3608
Query: 2971 VTYPNSQEAENW------KKIQEELNSRWERATEVTVARQRQLEES--ASHLACFQAAES 3022
+ Q+ + W KK EE+ + + EV Q L+ES S + C QA +
Sbjct: 3609 LMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGC-QATQL 3667
Query: 3023 QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG 3082
R + L++ VL +Q++F+ +E ++ + L+ +
Sbjct: 3668 TSR----YQALLLQVL--------------EQIKFLEEEIQSLEESESSLSSYSDWY--- 3706
Query: 3083 PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK-VRA 3141
G + V ++ ++ T + + ++ + + LL+ EK RA
Sbjct: 3707 -GSTHKNFKNVATKIDKVD------TVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERA 3759
Query: 3142 V-----GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 3196
V G+ ++ I E +K+ + LE+ H KE C L+ I E
Sbjct: 3760 VKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAE 3819
Query: 3197 Q----YLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 3252
++ +E K L L + L Q L+ + + ++ L+
Sbjct: 3820 YQEILHVPEEPKMELYEKKAQLSKYKSLQ-------QTVLSHEPSVKSVREKGEALLELV 3872
Query: 3253 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYE----VIVAEGESLLLSVPPGE 3308
Q K+ K+++LQS Q+ K++ + +E + +G++L+
Sbjct: 3873 QDVTLKD-----KIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHL 3927
Query: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368
+ + QN L+ + S + Q + + QK+ + L + C+A +S
Sbjct: 3928 QAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTL----QQCQAWLSA 3983
Query: 3369 LRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGIN 3428
++ L+P + L R++A + +V+ R+L E + D+L + + ++ I
Sbjct: 3984 VQPDLEP-SPQPPLSRAEA-IKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQ 4041
Query: 3429 QNMDAVTEEL---QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKH---QLEIFDALGSQ 3482
Q + ++L Q T EE+ E ++ +++++ K +LE+ A
Sbjct: 4042 QTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMV 4101
Query: 3483 ACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3542
+ ++KL+++Q + + +V+ L E++P+ + + L ++L+
Sbjct: 4102 SQVKDFVKKLQSKQASVNTIIEKVNKLTK-----KEESPEHKEINHL-------NDQWLD 4149
Query: 3543 VKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 3602
+ ++ N+ C+ E L+ +H + + L E D + D +S +E +
Sbjct: 4150 LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLAR--SDAESTAVHLEAL 4207
Query: 3603 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3662
+ + K IE + + + M+E D +K + L ++ +L + K R+ Q
Sbjct: 4208 KKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK-RKIQ 4266
Query: 3663 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIIN--QQLADFKMFQKEQVD 3720
+ +T L+ LN + E ++W + I +Q M Q +D
Sbjct: 4267 VSVT---------NLEELN--VVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMD 4315
Query: 3721 PLQM--KLQQVNGLGQGLIQSAGKDC------DVQGLEHDMEEINARWNTLNKKVAQRIA 3772
L + +L+ L + LI+ A + + Q ++ + + + N L+ V QR
Sbjct: 4316 HLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRK 4375
Query: 3773 QLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDR 3832
L +AL +F A+ S + E I ++ V Q++ K Q L
Sbjct: 4376 YLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTY 4435
Query: 3833 KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ 3892
+ V L A+G + + ++ ++ G+L+ L+S + +L K + R ++LE LV K
Sbjct: 4436 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4495
Query: 3893 FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIG 3952
F E + +L + + +++++ Q+ +++ + E + + + G
Sbjct: 4496 FKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTG 4555
Query: 3953 QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW 4012
Q++ + + LSEK+++L +++ I K + +A+ + +
Sbjct: 4556 QTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQS 4615
Query: 4013 LAEVED---KLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTT 4069
L+E+E ++S V ++ L Q A+ +E+ + VD+ + + ++T
Sbjct: 4616 LSELEAQFLRMSKVPTDLAVEEALSLQDGCR-AILDEVAGLGEAVDELNQKKEGF--RST 4672
Query: 4070 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL 4129
G+ +K+ + T Y + + + + LE + + ++L L+ V+EE
Sbjct: 4673 GQP--WQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQ 4730
Query: 4130 ATSGGQS-PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKL 4188
+ ++ P E++ + L+ + + V + +++ L L +AR
Sbjct: 4731 SKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARH----Q 4786
Query: 4189 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMA-------- 4240
+ + KL++ IG+ V E ++ + +S ++ L W+ K +L
Sbjct: 4787 IQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNL 4846
Query: 4241 ------LGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVL 4294
+ I++ Q++ + L++ A S HK+ E F+ E+ E L
Sbjct: 4847 QDIQEEIRKIQIHQEEVQSSLRIMNALS-----HKEK--EKFTKAKELISADLEHSLAEL 4899
Query: 4295 QEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPA 4354
E + + +E Y++ +R +++ ++ + W+E+ + L+ QL
Sbjct: 4900 SELDGDIQEALRTRQATLTEIYSQCQR-------YYQVFQAANDWLEDAQELL-QLAGNG 4951
Query: 4355 IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYA 4414
+D E + + + + + ++++L + L L G+ E+ QK ++
Sbjct: 4952 LDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGK--EDLEQKVASLEL 5009
Query: 4415 QIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI-PAEVDKIRE 4473
+ + R +D + Q ++ E ++E + + +L L+ + + E
Sbjct: 5010 RSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEE 5069
Query: 4474 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA------------------ 4515
+S++K+ + AL+ + +L A K +
Sbjct: 5070 KLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQ 5129
Query: 4516 ---KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
K ++D +D+ F +K +A E + D L + A LLT ++ V
Sbjct: 5130 DQEKILEDAVDEWTGFNNKVK-KATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5188
Query: 4573 DLESPGIDPSIIKQQV-----EAAETIKEETDGLHEELEFIR---ILGADLIFACGETEK 4624
+LE +++QQ + A E L +E+ ++ + + + G+ K
Sbjct: 5189 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5248
Query: 4625 PEVRKSIDEMNNAWENLNKTWKE---------------RLEKLEDAMQAAVQYQDTLQAM 4669
E++ EM N K W + +LE+L+ + A ++ ++ M
Sbjct: 5249 QELKDR--EMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKM 5306
Query: 4670 FDWLDNTVIKLCTMPP---------VGTDL---NTVKDQLNEMKEFKVEVYQQQIEMEKL 4717
+ + L T+ P V DL + ++D++ E+++ K + +++KL
Sbjct: 5307 AEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKL 5366
Query: 4718 NHQGELMLKKATDETDRDIIREPLTELKHLWENL---GEKIAHRQHKLEGALLALGQFQH 4774
+L K +TD + + T+ K L E L K+ ++ L GQ
Sbjct: 5367 AKDLTTILTKLKAKTDN--VVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5424
Query: 4775 ALEELMSWLT--HTEELLDAQRPISGDPKVIE--------VELAKHHVLKNDVLAHQATV 4824
L + + LT H + + A+ +S + +EL + K VLAH
Sbjct: 5425 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIA 5484
Query: 4825 ETVNKAGNE--LLESSAGDDASSLRSRLEAMNQ---------CWESVLQ-------KTEE 4866
E +L + +++ + S LEAM + C E + Q +TEE
Sbjct: 5485 WNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEE 5544
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAR----EQLDTHMEL 4922
Q ++ LQ Q +++ F EL ++++ L ++ T PE R EQL L
Sbjct: 5545 LRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5604
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
S++++ + + + + D S ++ L E+ + + +++ + ++
Sbjct: 5605 LSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ-CNIMQ 5663
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
A+ +++ ++ + A + + + + + +QI H+ A ++ +++Q
Sbjct: 5664 AAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQ 5723
Query: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
I L+ ++ K L+ K +L++V V+ E LD H
Sbjct: 5724 IASLN---SKCKMLTMKAKHA---TMLLTVTE-----VEGLAEGTEDLDGELLPTPSAHP 5772
Query: 5103 A--------WKKLIDWLEDAESHLDSELEISNDP--------DKIKLQLSKHKEFQKTLG 5146
+ L+ + + + EIS+ P +++ + + L
Sbjct: 5773 SVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS 5832
Query: 5147 GKQPVYDTT-IRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
++ D I + ++ P LG+++ W+T+ E+Q L EAL
Sbjct: 5833 AERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALE 5892
Query: 5206 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL 5265
++ D+LQ++ + +E +L+E P G + M H+ E+ + L
Sbjct: 5893 RQQKYQDSLQSISTKMEAIELKLSE-SPEPGRSP--ESQMAEHQALMDEILMLQDEINEL 5949
Query: 5266 KRS-GRELIENSRD----DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQAL-------- 5312
+ S EL+ S + + ++ L L+ R T+ + K+ LE+ L
Sbjct: 5950 QSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR 6009
Query: 5313 --KQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
+ + +R L WL + TL + P + +++ + + + ++E+K V +
Sbjct: 6010 QEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVAL 6069
Query: 5371 NSAVAMGEVIL----------AVCHPDCITTIK-HWITIIRARFEEVLTWAKQHQQRLET 5419
+ E +L A + +K + + RA ++ L Q++ E+
Sbjct: 6070 SELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEES 6129
Query: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
+ + ++E W+ A TT Q+ Q + Q ++ +AE ++ + + +
Sbjct: 6130 DVDLTATQSPGVQE---WLAQARTTWTQQRQSSLQQQ-KELEQELAEQKSLLRSVASRGE 6185
Query: 5480 DVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKS--LSQPTPPPMPILSQSEAKNPRINQLS 5537
++ I+ + A E S G K LSQ L K+ +Q+
Sbjct: 6186 EI----------LIQHSAA---ETSGDAGEKPDVLSQE-------LGMEGEKSSAEDQMR 6225
Query: 5538 ARWQQVWLLALERQRKLNDALDRLEE 5563
+W+ + +Q+ L + L++ +E
Sbjct: 6226 MKWESLHQEFSTKQKLLQNVLEQEQE 6251
Score = 225 bits (573), Expect = 1e-57
Identities = 563/3336 (16%), Positives = 1277/3336 (38%), Gaps = 328/3336 (9%)
Query: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKE 2158
+ +QN + K+++ ++E+ + L+ ++ + L + ++ + + + +K+
Sbjct: 314 NSVQNFKREDRVIFKEMKVWIEQFERDLTRAQM--VESNLQDKYQSFKHFRVQYEMKRKQ 371
Query: 2159 LEEAVTSALQQETEKSKAAKELAENKKKIDA-LLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
+E + L ++ + S + ++ ++ + L DW QL +LP GA
Sbjct: 372 IEHLI-QPLHRDGKLSLDQALVKQSWDRVTSRLFDWHI-------QLDKSLPAPLGTIGA 423
Query: 2218 SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH 2277
L + + + + V Q E+ + +H++LL A +G
Sbjct: 424 WLYRAEVALREE-ITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGI 482
Query: 2278 NLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSE 2337
+ P++ L ++ E++ + SE L +++ FL+ S L +E
Sbjct: 483 PVPPDQ-------LEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAE 527
Query: 2338 KELENMHKGGSSPETLPSLLKRQGSFSED---VISHKGDLRFVTISGQKVLDMENSFKEG 2394
+L++ E++ LL+ SF E+ ++ + + + + + + S +E
Sbjct: 528 SKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA 587
Query: 2395 KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE 2454
+ + N + T ++ L + + S L ++ + ++ N+ SLQAW++ E
Sbjct: 588 ENVMKFMN-------ETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAE 640
Query: 2455 ANV---EKLLSDTVASDPGVLQEQLATTK------QLQEELAEHQVPVEKLQKVAR---D 2502
+ E D + P +Q+ A + +E+ + + L R
Sbjct: 641 KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWREL 700
Query: 2503 IMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
ME++ D R +E TD ++ +LS E L + + S +++ L+
Sbjct: 701 FMEVKQYAQADEMDRMKKEYTDCVV----TLSAFATEAHKKLSEPLEVSFM---NVKLLI 753
Query: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2620
Q + ++EQ + + +A + + ++S E +EM
Sbjct: 754 QDLEDIEQRVP-----------VMDAQYKIITKTAHLITKESPQEEGKEMF--------- 793
Query: 2621 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2680
T + L+ +L +V + + L + Q+ L++L Q F GK+ + + R
Sbjct: 794 ATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLER--- 850
Query: 2681 SGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLR 2740
Q F Q+ QEL E+ ++ L +E + ++ +H D+
Sbjct: 851 ----EAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ----- 901
Query: 2741 KDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQ 2800
T LQ+ + + S ++ +++K V T + +K+ E S ELEK
Sbjct: 902 ---TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFE---------ESRAELEKV 949
Query: 2801 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2860
+ + L++ L+ + L+ ++
Sbjct: 950 LRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAF------------------------ 985
Query: 2861 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA-----ILNRMEEVHKEANSVLQW 2915
C +LT+I + L ++ LH++ + LQ +L+ +V K ++
Sbjct: 986 LKACDELTDILPEQEQQGL--QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKN-----RF 1038
Query: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQN---SPKIQKVKEALAGLLVT 2972
L S EE +D + E + + ++ F ++ + ++Q ++E L V
Sbjct: 1039 LASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVR 1098
Query: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
P +EL + + + R+L E + + S+ W+ E
Sbjct: 1099 DPVRDTPGTCHVTLKELRAAID-------STYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1151
Query: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 3092
+ + +ID K+ V+ + R + L + +LT +VS S ++
Sbjct: 1152 TQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLK-VLT---EVS-SENE 1206
Query: 3093 VQK---ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
QK EL ++ + L L+ + QY+E++++ E++ + + + Q
Sbjct: 1207 AQKQGDELAKLSSSFKALVTLLSEVEKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQ 1265
Query: 3150 S--AISTQPEAVKQQL-----EETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
+ + T+ QQL ++T I + + ++ +AQ GE L D
Sbjct: 1266 AEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQ---------GEGGLPDR 1316
Query: 3203 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 3262
+ L + L GLE + R+Q L ++F+ + + +L S +
Sbjct: 1317 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376
Query: 3263 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 3322
S+ LE L S+L++ +EF K + E +V E + L + K+ LQ Q +K
Sbjct: 1377 SS-LESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLG---PQNKQLLQQQAKSIKE 1432
Query: 3323 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 3382
++L + ++ K + + E L WI + + +++ L + + ++ S
Sbjct: 1433 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1492
Query: 3383 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDG-IRDEKAGINQNMDAVTEELQAK 3441
+ K + E+E + S + L A E I+ + I + + + E Q
Sbjct: 1493 I--KVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL 1550
Query: 3442 TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA 3501
G++ + ++F+E+ + I++ V + +L + + S A + + L+ ++ QA
Sbjct: 1551 EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSA--TETYKVLQEHMDLCQA 1608
Query: 3502 LEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
LE + F+ A + + +A QQ++ ++ +R +EN L
Sbjct: 1609 LESLSSAITAFS----ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLL--- 1661
Query: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA 3621
+ +E+ S L L+ + D + + ++E L I L+ ++ + +
Sbjct: 1662 AHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGE---LQLIQALQNEVVSQAS 1718
Query: 3622 ECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3681
+L+ + +L + K +++ + +L ER + + + + ++ + + +
Sbjct: 1719 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1778
Query: 3682 DATTAAEEAEAL---QWVVGTEVEIINQQLADFK--------MFQKEQVDPLQMKLQQVN 3730
+ + L + +E+ I++ Q+A + +K ++ LQ L ++
Sbjct: 1779 ELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLG 1838
Query: 3731 GLGQG----LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF-- 3784
LG+ L+Q +DC L ++ +Q + + Q AL H +F
Sbjct: 1839 SLGRAEDLHLLQGKAEDC----------------FQLFEEASQVVERRQLALSHLAEFLQ 1882
Query: 3785 -QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
+L +L L T E A E +++ + + + L+ ++D + ++
Sbjct: 1883 SHASLSGILRQLRQTVE--ATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKA 1940
Query: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
+ R + L + + +Q + + + VL K F + E +
Sbjct: 1941 QYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKS 2000
Query: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV----HQAVKIGQSLSSLT 3959
+ E++ +QQ++ LE+++ +H ++ +A +I Q +
Sbjct: 2001 IEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFA 2060
Query: 3960 SPAEQGV--LSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
++ + L D + E Q +CC L+ + + + +++V
Sbjct: 2061 PEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM-----------REYQNLKSAVSKVL 2109
Query: 4018 DKLSSVFV-----KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTT 4069
+ SSV V KD Q+ L + H ++ ++K++D G+ L LK+
Sbjct: 2110 ENASSVIVTRTTIKD--QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2167
Query: 4070 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW----LREV 4125
+ L++ ++ ++ D++ + + L + + ST +E+ GW + ++
Sbjct: 2168 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2227
Query: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
E ++ E + +F + E+K + + + VN++ L + +
Sbjct: 2228 AENISNLDNHLRAEELLKEF---ESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFI 2284
Query: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
+ + E K +++ + + A +S Q E+ + W + + LM
Sbjct: 2285 EADLMQKLEHAKEITEVAKGTLKDFTA---QSTQVEKFINDITTWFTKVEESLM-----N 2336
Query: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
Q++T L+ K ++ + ++ + + + + L LI+++
Sbjct: 2337 CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKH 2396
Query: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE 4365
EA+S L S+ A L+ + L F E+ +E W +A + D + L +
Sbjct: 2397 EAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
Query: 4366 EMRQLRESIAEHKPHIDKLLKIGPQL-KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
+++ + +S+++ + +D + + G L L+ + ++E+ KA + ++ +
Sbjct: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
Query: 4425 LALDEAVSQSTQITEFHDKIEPMLETL------ENLSSRLRMPPLIPAEVDKIRECISDN 4478
AL + S+ + H K+ + + ENL + P EV K+ + +
Sbjct: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGEL 2574
Query: 4479 KSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEE 4538
+A L+K L +RG+ L GA ++ Q++ +++ +E
Sbjct: 2575 LAARESLDK-------LSQRGQLLSEEGHGAGQE------GRLCSQLLTSHQNLLRMTKE 2621
Query: 4539 REIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP-GIDPSIIKQQVEAAETIKEE 4597
+ L+ E + ++ +K QD + ES G ++ K+ + + + +
Sbjct: 2622 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2681
Query: 4598 TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQ 4657
+G +L G + + + + ++ ++ + W ++ + LE +
Sbjct: 2682 GEG-EVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVIS 2740
Query: 4658 AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL 4717
Y + + W+++ K+ L L+ ++ E + +L
Sbjct: 2741 QWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRL 2800
Query: 4718 NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE 4777
+ + +K DE+ +D +E ELK + ++ + K+E + + A+
Sbjct: 2801 IAKSRELYEKTEDESFKDTAQE---ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2857
Query: 4778 ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837
E WL +E L +SGD + +L+K L + + + V E+ ++
Sbjct: 2858 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2917
Query: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897
+ + + ++A+ W+ + + L++ + Q E + +L +
Sbjct: 2918 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2977
Query: 4898 QLSASKPTGGLPETAREQLDTHME-----------LYSQLKAKEETYNQLLDKGRLMLLS 4946
Q SA T T E +T E L + KA+ T + L S
Sbjct: 2978 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3037
Query: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
RD S K V+ L ++++ + + + E+ L F+ + ++F WL A+
Sbjct: 3038 RDLSTYSGK----VSGLIKEYNCLCLQASKGCQNKEQILQ--QRFRKAFRDFQQWLVNAK 3091
Query: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
+ ++ V + +++ + F +E + ++ + G L L K+ I+
Sbjct: 3092 ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQ 3151
Query: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
+ + + W+ ++ +L++ + + K F + + + DWL E +
Sbjct: 3152 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEK------MVHE 3205
Query: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF---LGEVR 5183
+++ +K +E QK + ++ + R ++ L E +F + ++
Sbjct: 3206 SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLS 3265
Query: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD---L 5240
++ + + E+ +L+ + QF ++ L DW+ L D H D L
Sbjct: 3266 SQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHML--DSYCHPTSDKSVL 3323
Query: 5241 VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKL 5300
+ + + K ++ R L S + ++ QLQ + W ++
Sbjct: 3324 DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA 3383
Query: 5301 SVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336
+ +S+LE AL + ++D V W+ E L
Sbjct: 3384 GIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3419
Score = 199 bits (505), Expect = 9e-50
Identities = 435/2542 (17%), Positives = 998/2542 (39%), Gaps = 243/2542 (9%)
Query: 2913 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2961
+++LE K +L + S K+ E+V+ ++ +F+ EQ Q
Sbjct: 510 MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 569
Query: 2962 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 3021
+K+ + + +EAEN K E ++W + + + LEE S+ +
Sbjct: 570 LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 629
Query: 3022 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 3081
+ L+ WL + E MLN + + + QQH +N+A ++
Sbjct: 630 ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 676
Query: 3082 GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRA 3141
+ + + ++++L +N +W EL ++ + +Q D+ +Y + + LS
Sbjct: 677 TCDE--MVSRDLKQQLLLLNGRWRELFMEV-KQYAQADEMDRMKKEYTDCVVTLSAFATE 733
Query: 3142 VGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 3201
++LS +S VK +++ +I + +D + K + + + LI ++ ++
Sbjct: 734 AHKKLSEPLEVSFM--NVKLLIQDLEDIEQRVPVMDAQYK----IITKTAHLITKESPQE 787
Query: 3202 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 3261
E K+ T + L++ L +QQ +EL + K
Sbjct: 788 EGKEMFAT----MSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 843
Query: 3262 ISAKLER-LQSQLQENEEFQKSL--NQHSGSYEVIVAEGES------LLLSVPPGEEKRT 3312
I LER QS ++ Q+ L ++ ++ +G L +V ++
Sbjct: 844 IITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR 903
Query: 3313 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 3372
LQ Q+ ++ ++ + KKT D + ++ + +K++ +L + + + E
Sbjct: 904 LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKG-- 961
Query: 3373 LDPVQLESSLLRSKAMLNEVEKR--RSLLEILNSAADILINSSEADEDGIRDEKAGINQN 3430
DP +L L R +++++R + L+ + DIL E ++ G+++ +++
Sbjct: 962 -DPEEL---LRRHTEFFSQLDQRVLNAFLKACDELTDIL---PEQEQQGLQEAVRKLHKQ 1014
Query: 3431 MDAVTEELQAKTGSLE---EMTQRLREFQESFKNIEKKV-----EGA----KHQLEIFDA 3478
+ E L+ E + L +E ++++ EG+ K F
Sbjct: 1015 WKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD 1074
Query: 3479 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ 3538
G K L+ + L +P V D P
Sbjct: 1075 KGPHHLCEKRLQLIEELCVKLPVRDP------------VRDTPG------------TCHV 1110
Query: 3539 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT---DSL 3595
E++ ++S + + + R E S ++ + +L G+ DT +
Sbjct: 1111 TLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV 1170
Query: 3596 QSQIEDVR---------LFLNKIHVLKLDIEASEAECRHMLEEEGTLD-----LLGLKRE 3641
+ +E++R L K + L +SE E + +E L L+ L E
Sbjct: 1171 KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSE 1230
Query: 3642 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3701
+E + G + + + LE + ++ + + + D E + L
Sbjct: 1231 VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLL-------- 1282
Query: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3761
+ +QQ +K V + QQ G+G + G + ++ ++ + +
Sbjct: 1283 -LHHQQKTKRISAKKRDVQQQIAQAQQ----GEGGLPDRGHE--------ELRKLESTLD 1329
Query: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS-AEYKVVKAQIQ 3820
L + ++ ++Q L +F+ E ++ +L T ++++ S + + + ++++
Sbjct: 1330 GLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSELE 1387
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
+ K + + + L E I + +++ + Q +S++ + +L
Sbjct: 1388 QTKEFSKRTESIAVQAENLVKEASEIPLGPQ--NKQLLQQQAKSIKEQVKKLEDTLEEDI 1445
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
K +E + F E +S +++ EK+L E T ++ + QI + K ++IE+
Sbjct: 1446 KTMEMVKTKWDHFGSNFETLSVWITEKEKELNALE---TSSSAMDMQISQIKVTIQEIES 1502
Query: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC-CRKAALLDQALSNA 3999
+ + + QS + + E + K+ ++ E+++ C + +L LS
Sbjct: 1503 KLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH-LSQQ 1561
Query: 4000 RLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 4059
+ F E+ ++ ++E EDKL+ ++ +H+ L + + +++ AI
Sbjct: 1562 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL----ESLSSAIT 1617
Query: 4060 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELT 4119
A ++ + + ++ ++ +Y DI + + LE L +Q +EL+
Sbjct: 1618 AFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALE---NLLAHWQRLEKELS 1672
Query: 4120 GWLREVE--EELATSGGQSPTGEQIPQFQQRQ--KELKKEVMEHRLVLDTVNEVSRALLE 4175
+L +E E A+S + +++ + Q + L+ EV+ + ++ +L
Sbjct: 1673 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1732
Query: 4176 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETK 4235
+ + + + +E+++ + I +R++ + + + QQ+++ + W+
Sbjct: 1733 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---- 1788
Query: 4236 RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI---------FGTC 4286
+ L + QTT+++ + + + RHKD E+ S + E+ G+
Sbjct: 1789 -------KLFLSELQTTSEISIMD-HQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSL 1840
Query: 4287 GE-EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
G E +LQ K E Q +E S + R L + +F +++ LS + + R
Sbjct: 1841 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----LAEFLQSHASLSGILRQLRQ 1896
Query: 4346 LIAQLPSPAIDHEQLRQQQ-EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 4404
+ S + L ++ + Q +++ +D +L L E
Sbjct: 1897 TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY--HLKIGSSEQRTS 1954
Query: 4405 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464
A+ + +++ EA + + F D+ E +L+++E++ R L
Sbjct: 1955 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2014
Query: 4465 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKEIQDKLD 4523
+++ + EL + LK + +++ A KD+A A E+ +++
Sbjct: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREIN 2068
Query: 4524 QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI 4583
++ W+D K E + + +++L ++ +A+ +++ ++ + D
Sbjct: 2069 RLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI-VTRTTIKDQED 2127
Query: 4584 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE---VRKSIDEMNNAWEN 4640
+K ET K + + ++L+ G L+ + + V+ ++ + W +
Sbjct: 2128 LKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLD 2187
Query: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE- 4699
+++ +E +++L ++ T + W +N V P + +++ + + L
Sbjct: 2188 VSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCV------PQMAENISNLDNHLRAE 2241
Query: 4700 --MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4757
+KEF+ EV + + +E+L+ K D + E +L+ + +L +K+ H
Sbjct: 2242 ELLKEFESEVKNKALRLEELH-------SKVNDLKELTKNLETPPDLQFIEADLMQKLEH 2294
Query: 4758 RQHKLEGALLALGQF-------QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
+ E A L F + + ++ +W T EE L ++ L K
Sbjct: 2295 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL-----MNCAQNETCEALKKV 2349
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
++ ++ + Q+ + + + N L + SL + + + E+V Q + +
Sbjct: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
LQ +L+ + F +++F ++ S G + +L + + +
Sbjct: 2410 LQESLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2467
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATE 4990
+ + +G+ L + S ++ + +++ + + K L++ +
Sbjct: 2468 SKLDAVTQEGQ-TLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGS 2526
Query: 4991 FQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV--FANEVNAHRDQIIELDQ 5048
F++ ++ W+ E+ N + + + E HKV F E+ A R+ + +L Q
Sbjct: 2527 FEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2586
Query: 5049 TGNQLKFLSQK-----QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103
G + LS++ Q+ L LL S Q+ +++ + E+ RS A + + EA
Sbjct: 2587 RG---QLLSEEGHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEA 2639
Query: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG-RAL 5162
+ + W++ + L D ++ +LS+ ++ G + + I G +AL
Sbjct: 2640 LQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL 2699
Query: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
+ E + + L +++ W + SV Q LE + +++ L W+
Sbjct: 2700 RSSN--KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWME 2757
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTW 5282
V+ ++ L L+D + E T + L REL E + D++
Sbjct: 2758 SVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFK 2817
Query: 5283 VKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL 5342
Q +EL T+++ + ++ K ++E+ +K ++ D VH +WL A++ L +
Sbjct: 2818 DTAQ-EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2876
Query: 5343 PDDTEALQSLIDTHKEFMKKVE 5364
D+ A Q + KE + E
Sbjct: 2877 SGDSSATQKKLSKIKELIDSRE 2898
Score = 146 bits (369), Expect = 5e-34
Identities = 417/2292 (18%), Positives = 875/2292 (38%), Gaps = 307/2292 (13%)
Query: 1848 ERELKDLTTLVS--QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSR 1905
ER L+DL L+ QE +Q II +E QLL ++ + L+ + +++T +
Sbjct: 6521 ERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI-LTETLFRK 6579
Query: 1906 LLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILN---SKGSNSEIDVDSLNLC 1962
++ F AV+ K HT+L + + + + L S+ + D L+
Sbjct: 6580 IISF--AVQ----KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQ 6633
Query: 1963 LQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQR-----SF 2017
L+ E + + D L I + +H + + ++ ++L++ +R S
Sbjct: 6634 LEVVESSIPSVGLVEENEDRLIDRITLY--QHLKSSLNEYQPKLYQVLDDGKRLLISISC 6691
Query: 2018 QDILEQTAAQVDALQGHLQQMEQEA-LVKTLQKQQNTCHQQLEDLCSWVGQAERALA--G 2074
D+ Q + + +M +E ++T+ K + DL W+ A+ L
Sbjct: 6692 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6751
Query: 2075 HQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTAL 2134
Q T Q+L ++ + + + ++ +++ ++V+ + +L + L
Sbjct: 6752 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-----RLKKVDTATL 6806
Query: 2135 REKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWV 2194
R +L + Q+ L Q++L + LQ + S+ A I ++ W+
Sbjct: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQ-----LQMDKLPSRHA---------ISEVMSWI 6852
Query: 2195 TSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEK-----LDKQCEMMKA 2249
+ L+ N+ ++ + + GY +++ +K +D C+ +
Sbjct: 6853 S--------LMENV--------IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTV 6896
Query: 2250 R--HQELLSQQQNFILATQSAQA-FLDQHG---------HNLTPEEQQMLQQKLGELKEQ 2297
+Q +L + + +S + F +Q G L E+ Q+L+ L E
Sbjct: 6897 DFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEY 6956
Query: 2298 YS------TSLAQSEAELKQVQTLQDE--LQKFLQDHKEFESWLERSEKELENMHKGGSS 2349
+ T E LKQ + D+ +Q L+D ++ E ++ EKE+E + + G +
Sbjct: 6957 ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLA 7016
Query: 2350 ---------PETLPSLLKRQG------------------SFSEDVISHK----------- 2371
+ S L+ G S + SHK
Sbjct: 7017 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLM 7076
Query: 2372 -------------GDLRFVTISGQKVLDMENSF-KEGKEPSEIGNLVKDKLKDATERYT- 2416
G L V + + ++++ K+ + + G++ LK+ T
Sbjct: 7077 EARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 7136
Query: 2417 ALHSKCTRLGSHLNMLLGQY-HQFQNSADSLQAWMQ------ACEANVEKLLSDT----- 2464
L + + N LL + Q Q+S LQ W + C + V++ T
Sbjct: 7137 TLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLK 7196
Query: 2465 VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI--EGEPAPDHRHVQETTD 2522
A++ + +++AT Q +L + V+ ++ E + A +Q
Sbjct: 7197 AATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQL 7256
Query: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS-G 2581
S+ H +L +L ++ + LQ + ++ +SLE+L I E E+ L+G+ S S
Sbjct: 7257 SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLS 7316
Query: 2582 VIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLC 2641
IQE + + L+ E+ R ++ +++ + +
Sbjct: 7317 TIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK------RMQNLNRHWSLIS 7370
Query: 2642 LQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA---SGNQPDQDITHFFQQIQE 2698
Q E+ S L+ L Q + F +F+ + LA SGN H +Q +
Sbjct: 7371 SQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ-----HLLEQQRA 7425
Query: 2699 LNL---EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2755
L EM +Q+ L ++ L G D + ++ L + + + ++R
Sbjct: 7426 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7485
Query: 2756 DASSCQEQLDEFRKLVRTFQKWLKETE-------GSIPPTETSMSAKELEKQIEHLKSLL 2808
S Q +R++ +KWL E GS+P ++ ++L
Sbjct: 7486 IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIP------------LQQARTLF 7533
Query: 2809 DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLT 2868
D+ K E++ + L +E GK +L S S +
Sbjct: 7534 DEVQFK----EKVFLRQQGSYILTVEA------GK--QLLLSADSGAEAA---------- 7571
Query: 2869 EIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLES-KEEVLKSMD 2927
+Q +++++ K++ L E+++ L +L E+ K L+ L + K+++ +S+
Sbjct: 7572 -LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7630
Query: 2928 AMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQE 2987
E ++ + N + + ++ +K+ L+ Y ++ + + E
Sbjct: 7631 DHHEELHAEQMRCKELENA--VGSWTDDLTQLSLLKDTLSA----YISADDISILNERVE 7684
Query: 2988 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM 3047
L +WE R++Q+ E + A F +L WL + E + G + I+ M
Sbjct: 7685 LLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIE-EM 7743
Query: 3048 LNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVEL 3107
+ K+ Q + + + Q +Q+ E S+++ +L +N +W L
Sbjct: 7744 IEKLKKDYQEEIAIAQENKIQLQQMGERL-----AKASHESKASEIEYKLGKVNDRWQHL 7798
Query: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAI-STQPEAVKQQLEET 3166
D + +R ++ + +V Q + + L + + L+ S E ++++L E
Sbjct: 7799 LDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQ 7858
Query: 3167 SEIRSDLEQLDHEVKEAQTLCDEL---SVLIGEQYLKDELKKRLETVALPLQGLEDLAAD 3223
E++ D+E+ V LC+ L D +++ + + + ++ +
Sbjct: 7859 QELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSME 7918
Query: 3224 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKL--ERLQSQLQENEEFQK 3281
R +++ Q+F + WL K S++ P S+ + + +L++ E FQ+
Sbjct: 7919 RRLKIEETWRLWQKFLDDYSRFEDWL--KSSERTAAFPSSSGVIYTVAKEELKKFEAFQR 7976
Query: 3282 SLNQHSGSYEVIVAEGESLLLSVPPGEEKRT-----LQNQLVELKNHWEELSKKTADRQS 3336
+++ E+I + L E RT L+ + E W+ L K+
Sbjct: 7977 QVHECLTQLELINKQYRRL------ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILR 8030
Query: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRR 3396
RLK + + ++++ + ++ W+ + +++ + +++ + + KA E+
Sbjct: 8031 RLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDVQAKIKQLKAFQQEISLNH 8089
Query: 3397 SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRL---- 3452
+ +E + + + LI SE + I I + +D + Q G +E ++L
Sbjct: 8090 NKIEQIIAQGEQLIEKSEPLDAAI------IEEELDELRRYCQEVFGRVERYHKKLIRLP 8143
Query: 3453 ---REFQESFKNIEKKVEGAKHQLEIFDA-----LGSQACSNKNL---EKLRAQQEVLQA 3501
E S + +E + A L D L Q SN +L + LR+++
Sbjct: 8144 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8203
Query: 3502 --------LEPQVDYLRN------FTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRV 3547
LE DY + ++ L + +G D + V + + + +
Sbjct: 8204 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM-IPESP 8262
Query: 3548 NSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIED-VRLFL 3606
+ + EN ++ H + QL D D I + + ++S+ L
Sbjct: 8263 EAYVKLTENAIKNTSGDHSALESQIRQLGKALD--DSRFQIQQTENIIRSKTPTGPELDT 8320
Query: 3607 NKIHVLKLDIEASEA-----ECRHMLEEE-----GTLDLLGLKRELEALNKQCGKLTERG 3656
+ +KL E S + H L+EE G ++L + + + + L +
Sbjct: 8321 SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 8380
Query: 3657 KARQEQLELTLGRVEDFYRKLKG----LNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3712
+++ +++ L + + F L L D E+ + L+ + T+++ I Q+ K
Sbjct: 8381 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLK 8438
Query: 3713 MFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA 3772
QK VD + + +N Q+ K+ + L+ + ++N RW+ + + +
Sbjct: 8439 ELQKA-VDHRKAIILSINLCSPEFTQADSKES--RDLQDRLSQMNGRWDRVCSLLEEWRG 8495
Query: 3773 QLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQ--RLLD 3830
LQ+AL+ C F + LL L + + P + Q ++L+Q L
Sbjct: 8496 LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 8555
Query: 3831 DRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLA 3890
+ + V LQ ++ +AE D + ++ + +R LL + + K+LE +L ++
Sbjct: 8556 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS 8615
Query: 3891 KQFHETAEPISDFLSVTEKKLANS-EPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAV 3949
+ + +S + S E + S P ++ +Q+ R K + H
Sbjct: 8616 ----SSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRS 8671
Query: 3950 KIGQSLSSLTSP 3961
G S SSL+ P
Sbjct: 8672 TKGGSDSSLSEP 8683
Score = 143 bits (361), Expect = 4e-33
Identities = 377/2142 (17%), Positives = 819/2142 (38%), Gaps = 260/2142 (12%)
Query: 3510 RNFTQGLVEDAPDGSDASQLLHQAEVAQQ---EFLEVKQRVNSGCVMMENKLEGIGQFHC 3566
R + L+++ + S+ Q EV Q + E+ + + EN ++ + +
Sbjct: 540 RESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTA 599
Query: 3567 RVR----EMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAE 3622
+ R E+ S + L++ + G SLQ+ +ED LN+ K D +
Sbjct: 600 QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRN--- 656
Query: 3623 CRHMLEEEGTLDLLG--------------LKRELEALNKQCGKLTERGK--ARQEQLELT 3666
H +++ ++ G LK++L LN + +L K A+ ++++
Sbjct: 657 LPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRM 716
Query: 3667 LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKL 3726
D L AT A ++ V V+++ Q L D + Q+ V Q K+
Sbjct: 717 KKEYTDCVVTLSAF--ATEAHKKLSEPLEVSFMNVKLLIQDLEDIE--QRVPVMDAQYKI 772
Query: 3727 --QQVNGLGQGLIQSAGKD--CDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
+ + + + Q GK+ + L+ + ++ ++ L + Q + L+E
Sbjct: 773 ITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMT 832
Query: 3783 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
F D+L + + ++ + SA +K Q+ + L ++ K T+ +++
Sbjct: 833 SFYDSLGKINEIIT----VLEREAQSSALFK------QKHQELLACQENCKKTLTLIEKG 882
Query: 3843 GGRIAQSAELA------DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHET 3896
+ + L+ D+ ++ Q+ + + ++ K +K +E L K+F E+
Sbjct: 883 SQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEES 942
Query: 3897 AEPISDFLSVTEKKLANS----EPVGTQT---AKIQQQIIRH--KALEE--DI--ENHAT 3943
+ L + ++ L E + T +++ Q+++ KA +E DI E
Sbjct: 943 RAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQ 1002
Query: 3944 DVHQAV-KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC----RKAALLDQA--- 3995
+ +AV K+ + L A +L KID + R+ + C R+ L+ Q
Sbjct: 1003 GLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSE 1062
Query: 3996 --LSNARLFGEDE------------VEVLNWLAEVEDKLSS------VFVKDFKQ--DVL 4033
+ R+F D+ +E L V D + V +K+ + D
Sbjct: 1063 KIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST 1122
Query: 4034 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ---------------- 4077
+R+ + ++ +R I + LK GE +
Sbjct: 1123 YRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVT 1182
Query: 4078 ---EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGG 4134
E L +K+R +T SS+ +Q +LA K S+++ L L EVE+ L+ G
Sbjct: 1183 KRGETLSWLKSRLKVLTEVSSEN-EAQKQGDELA-KLSSSFKALVTLLSEVEKMLSNFGD 1240
Query: 4135 QSPTGEQIPQFQQRQKELKKEVMEH-RLVLDTVN--EVSRALL----------------E 4175
E + + KEV E +LDT N E + LL +
Sbjct: 1241 CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQ 1300
Query: 4176 LVPWRAREGLDKLVSDANEQYKLVSDTIG-------QRVDEIDAAIQRSQQYEQAADAEL 4228
+A++G L +E+ + + T+ ++ I +++ +++E + +
Sbjct: 1301 QQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVV 1360
Query: 4229 AWVAET---KRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285
++ +T + ++ + + +++L+ K FS + L SEI
Sbjct: 1361 RYLFQTGSSHERFLSFSSL----ESLSSELEQTKEFSKRTESIAVQAENLVKEASEI--P 1414
Query: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
G + K +LQ++ +S+ +Q + + E +E + + F +E LS WI E
Sbjct: 1415 LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEK 1474
Query: 4346 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 4405
+ L + + + ++ Q++ +I E + + ++ + + + +
Sbjct: 1475 ELNALETSSSAMDM------QISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR 1528
Query: 4406 YQKAENMYAQIKEEVRQRALALDEAV-SQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464
+ + EE+R+ A L+ + +Q +F + + + +++ +L +P I
Sbjct: 1529 IKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI 1588
Query: 4465 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4524
+ + + + ++ LE L + A +++ R + A ++
Sbjct: 1589 CSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQ------ 1642
Query: 4525 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4584
+EDI RA+ER+ ++L ++ ++++ LT ++ + SP +D S
Sbjct: 1643 ----YEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEA---KASSPEMDISAD 1695
Query: 4585 KQQVEAA----ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4640
+ +VE + ++ E + L L + + ++ +++++ W +
Sbjct: 1696 RVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755
Query: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG-----TDLNTVKD 4695
L + +R+ L+ + Q+ + L + W+ + +L T + L KD
Sbjct: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKD 1815
Query: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4755
E++ K E+ Q + KL G D +++ + L+E + +
Sbjct: 1816 HAAEVESKKGELQSLQGHLAKLGSLGRA--------EDLHLLQGKAEDCFQLFEEASQVV 1867
Query: 4756 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKVIEVELAKHHVLK 4814
RQ AL L +F + L L + ++A ++ + +IE +L
Sbjct: 1868 ERRQL----ALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDL------- 1916
Query: 4815 NDVLAHQATVETVNKAGNELLESSA-----GDDASSLRSRLEAMNQCWE----SVLQKTE 4865
ND L + +E+ + + +L + G R A C E L T+
Sbjct: 1917 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1976
Query: 4866 EREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQ 4925
+ E + L++A F + E+ L + +E + + L E R+ L + +++Q
Sbjct: 1977 QSEADALAVLKKA--FQDQKEELLKSIEDIEERTDKER----LKEPTRQALQQRLRVFNQ 2030
Query: 4926 LKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983
L+ + ++ L K + +++ D + ++ + LE W + E + +
Sbjct: 2031 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCG 2090
Query: 4984 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ------IEEHKVFANEVN 5037
++L E+QN + + L AS + T+ Q +H+ N++N
Sbjct: 2091 LIDLMREYQNLK-------SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMN 2143
Query: 5038 AHRDQIIELDQTGNQLKFLSQK---QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 5094
+ + G L +K D L+K + S +W V ++ L++
Sbjct: 2144 YKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK-------LEENM 2196
Query: 5095 KRAKQFHEAWKKLIDWLEDAESHLDSEL-----EISNDPDKIKLQLSKHKEFQKTLGGKQ 5149
R + W ++ ++ E ++ + ISN + ++ + KEF+ + K
Sbjct: 2197 DRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE-ELLKEFESEVKNKA 2255
Query: 5150 PVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
+ LKE T E L ++ K + + + L++ S Q
Sbjct: 2256 LRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQ 2315
Query: 5210 FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL---- 5265
+ + W KVE L + + + + D K Q + + T + L
Sbjct: 2316 VEKFINDITTWFTKVEESLMNCAQ-NETCEALKKVKDIQKELQSQQSNISSTQENLNSLC 2374
Query: 5266 -KRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHM 5324
K EL R T +K + + V +L Q+ L+++L++ F +++
Sbjct: 2375 RKYHSAELESLGRAMTGLIK--------KHEAVSQLCSKTQASLQESLEKH--FSESMQE 2424
Query: 5325 LLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 5384
EW A+ + D++ L++ + + + V + + +++ G+ + A
Sbjct: 2425 FQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHL 2484
Query: 5385 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 5444
+++I+ IT F+ L + +Q L+ SEL + + +L WI E
Sbjct: 2485 SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER 2544
Query: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTK 5486
+ Q+I K + + + F+ E+ + +D++++
Sbjct: 2545 FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2586
Score = 117 bits (292), Expect = 4e-25
Identities = 357/1946 (18%), Positives = 770/1946 (39%), Gaps = 302/1946 (15%)
Query: 1809 KLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLEREL--KDLTTLVSQELECVN 1866
+++S++SL+ N+ + + + + + L + K + ++ K LT ++ VN
Sbjct: 6847 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT------VDFVN 6900
Query: 1867 QIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK-VLNQHT 1925
Q ++ ++ +Q +++ D + + L +++ +W ++L +I+ + +L +
Sbjct: 6901 QSVL----QISSQDVESKRSDKTDFAEQLGAMNKSW--QILQGLVTEKIQLLEGLLESWS 6954
Query: 1926 QLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAF 1985
+ E +Q L+ W + L K + D S+ L+ +DL+ + ++ +++ +
Sbjct: 6955 EYENNVQCLKTWFETQEKRL--KQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
Query: 1986 DIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK 2045
+ I +D+S ++ L EL QT A +D + G L+ L+K
Sbjct: 7013 NGLALIQNKKEDVSSI----VMSTLRELG--------QTWANLDHMVGQLK-----ILLK 7055
Query: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRA 2105
++ Q ++ + + S++ +A +L+ + R L A+Q +L++LQDD++ +
Sbjct: 7056 SVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQVDNLQNLQDDLEKQE 7113
Query: 2106 TSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTS 2165
S ++E P L L + ++ L EE Q + +A+
Sbjct: 7114 RSLQKFGSITNQLLKE----CHPPVTETLTNTLKEVNMRWNNLLEEI-AEQLQSSKALLQ 7168
Query: 2166 ALQQETEKSK-AAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGAL 2224
Q+ + SK A + + + + + LL T+ + ++ T + L KG
Sbjct: 7169 LWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL-----KGLG 7223
Query: 2225 DTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQ 2284
D +++ E+L +Q + A A QS Q L QH L EQ
Sbjct: 7224 TVKDSLFFLHELGEQLKQQVDASAAS-------------AIQSDQLSLSQH---LCALEQ 7267
Query: 2285 QMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMH 2344
+ +Q+ TSL Q L + + F + + E+W+ +E+ L+
Sbjct: 7268 ALCKQQ---------TSL--------QAGVL--DYETFAKSLEALEAWIVEAEEILQGQD 7308
Query: 2345 KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLV 2404
SS L ++ +R + L+F +++ E ++ EI
Sbjct: 7309 PSHSSD--LSTIQERMEELKGQM------LKFSSMAPDLDRLNELGYRLPLNDKEI---- 7356
Query: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDT 2464
++++ ++ + S+ T S L L Q+ F + + WM+ +KL +
Sbjct: 7357 -KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAVEI 7412
Query: 2465 VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSI 2524
+ +L++Q A E + Q+ L + D + + D R ++
Sbjct: 7413 SGNYQHLLEQQRAHELFQAEMFSRQQI----LHSIIIDGQRLLEQGQVDDRDEFNLKLTL 7468
Query: 2525 LSH-FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2583
LS+ +Q + +R ++ I Q Q +E E L + + EV +S L S I
Sbjct: 7469 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY----LPMSGLGSVPI 7524
Query: 2584 --QEA--LATNMKLKQDI-ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE 2638
Q+A L ++ K+ + RQ+ S T E + + +ADS A LQ +LAE+ ++++
Sbjct: 7525 PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWK 7584
Query: 2639 Q--LCLQQQEK---------ESSLKKLLPQAEMFEHLSGKLQQFMENKSRML-------- 2679
+ L++Q+K E K + E KL Q + + L
Sbjct: 7585 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCK 7644
Query: 2680 ----ASGNQPDQDITHFF------------QQIQELNLEMEDQQENLDTLEH-LVTELSS 2722
A G+ D D+T I LN +E Q + L H L
Sbjct: 7645 ELENAVGSWTD-DLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQ 7703
Query: 2723 CGFAL-----------DLCQH----------------QDRVQNLRKDFTELQKTVKEREK 2755
G L +LC+ ++ ++ L+KD+ E +E +
Sbjct: 7704 IGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKI 7763
Query: 2756 DASSCQEQLDEFR----------KLVRTFQKW-------------LKETEGSIPPTETSM 2792
E+L + KL + +W LKET ++ + +M
Sbjct: 7764 QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 7823
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLE-NLIMEITAPDSQGKTG--SILP 2849
S+ L + H++S L +K + + N + + N E+ + TG S+L
Sbjct: 7824 SS--LRTWLAHIESEL----AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLN 7877
Query: 2850 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909
+ + T + IQ +++ ++ + + ER+ ++ ++ +
Sbjct: 7878 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 7937
Query: 2910 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2969
+ WL+S E + SS K + + +AF ++ + +++ + + L
Sbjct: 7938 SRFEDWLKSSERT--AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 7995
Query: 2970 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 3029
+ A + K++ E N RW+ + + R+L+ F+ A + WL
Sbjct: 7996 -ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 8054
Query: 3030 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPG 3084
E +L + N+ + + VQ +K+ +A +Q+ H ++ + AQG
Sbjct: 8055 EMDLQL---------TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 8105
Query: 3085 DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144
L + +++EL + + E+ ++ ++ + + ++ ++L + A
Sbjct: 8106 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 8165
Query: 3145 RL-----SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYL 3199
L S S +S QP + L +RS+ ++ D + + Y
Sbjct: 8166 DLHWHDRSADSLLSPQPSS-NLSLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY- 8218
Query: 3200 KDELKKRLETV---ALPLQGLEDLAADRINRLQAALA--------STQQFQQMFDE-LRT 3247
+L + LE+ ALP + E+ D+ L+ A+ S + + ++ + ++
Sbjct: 8219 --DLSRDLESAMSRALPSED-EEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKN 8275
Query: 3248 WLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKS-------LNQHSGSYEVIVAEGESL 3300
D + +++ + L+ + Q+Q+ E +S L+ Y ++ E S
Sbjct: 8276 TSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSS 8335
Query: 3301 LLSVPPGEEK--------------RTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQ 3346
+ SV E K + + Q + + WE L + ++ R+K +QK Q
Sbjct: 8336 IDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQ 8395
Query: 3347 KYQWHVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 3403
++ + + W+ D + ++ +L+ ++ D +E + + K + V+ R++++ +N
Sbjct: 8396 QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 8455
Query: 3404 SAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI- 3462
+ + + ++D + +N D V L+ G L++ + + F E +
Sbjct: 8456 LCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLL 8515
Query: 3463 --EKKVEGAKHQLEIFDA-LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVED 3519
+ ++ K+++ D+ L ++ + + + ++ + E+L++ + +V L++ + L+ +
Sbjct: 8516 LMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES-QLRVASLQDMSCQLLVN 8574
Query: 3520 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3579
A +G+D + + V + + V+ +E L ++ S DL
Sbjct: 8575 A-EGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL-----------DVSSSQQDLS 8622
Query: 3580 -----DELDGMGAI----GRDTDSLQ 3596
DELD G++ GR T + Q
Sbjct: 8623 SWSSADELDTSGSVSPTSGRSTPNRQ 8648
Score = 116 bits (291), Expect = 6e-25
Identities = 355/2008 (17%), Positives = 756/2008 (37%), Gaps = 273/2008 (13%)
Query: 3648 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3706
Q + ER EL L ++E K + L+ A E++ W++ E + Q
Sbjct: 488 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 545
Query: 3707 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764
L ++ F + + ++ Q + + +++ G + + + M E A+W L+
Sbjct: 546 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 605
Query: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824
+V + L+E + + ++ + + L +WL D E+++ + ++ +
Sbjct: 606 VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFF---------RN 656
Query: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
L + A D G + ++ + + QL L RW EL + + Q +
Sbjct: 657 LPHWIQQHTAMNDA----GNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVK-QYAQAD 711
Query: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944
++ + K++ + +S F + KKL+ V K+ Q + EDIE
Sbjct: 712 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 765
Query: 3945 VHQAVKIGQSLSSLT---SPAEQGV-LSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3998
+ KI + L SP E+G + + L+ + +++++ C L + Q L
Sbjct: 766 MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 823
Query: 3999 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 4057
+ + L ++ + + +V ++ + L +Q H + LA E N KK +
Sbjct: 824 LEELEKQMTSFYDSLGKINE-IITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 879
Query: 4058 IKNGQALLKQTTGEEVLL------IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 4111
K Q++ K T VL +Q ++ I + + + + +E +L KF
Sbjct: 880 EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 939
Query: 4112 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 4171
+ + EL LR +E L G + +R E ++ + VL+ +
Sbjct: 940 EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 990
Query: 4172 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 4231
L +++P + ++GL + V ++Q+K +Q Y L
Sbjct: 991 ELTDILPEQEQQGLQEAVRKLHKQWK---------------DLQGEAPYHLL---HLKID 1032
Query: 4232 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 4291
E R L ++ R E D+ T +L Q+ I H+ + H C E++
Sbjct: 1033 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1085
Query: 4292 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 4337
+++E L + E + ++S Y +L + + E S
Sbjct: 1086 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST-YRKLMEDPDKWKDYTSRFSEFS 1144
Query: 4338 PWIEETRALIAQLPSPAID---HEQLRQQQEEMR----QLRESIAEHKPHIDKLLKI--- 4387
WI + + AID H ++++ EE+R + E+++ K + L ++
Sbjct: 1145 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSE 1204
Query: 4388 ------GPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRAL---ALDEAVSQSTQIT 4438
G +L +L+ +V + E M + + V+ + + +L+E +S S ++
Sbjct: 1205 NEAQKQGDELAKLSSSFKALVT-LLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQ 1263
Query: 4439 EFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRR 4498
E +KI L+T ENL L+ K + + + ++ + Q L R
Sbjct: 1264 EQAEKI---LDT-ENL---FEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDR 1316
Query: 4499 GEELIGRSQGADKDLA-AKEIQDKLDQMVFF-WEDIKARAEEREIKFLDVLELAEKF--W 4554
G E + + + L ++E Q++ Q+ WE + E E+F +
Sbjct: 1317 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376
Query: 4555 YDMAALLTTIKDTQDIVHDLESPGI-----------------DPSIIKQQVEAA-ETIKE 4596
+ +L + ++ T++ ES + + +++QQ ++ E +K+
Sbjct: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKK 1436
Query: 4597 ETDGLHEELEFIRIL-------GADL-IFACGETEKPEVRKSIDEMNNAWENLNKTWKER 4648
D L E+++ + ++ G++ + TEK + +++ ++A + K
Sbjct: 1437 LEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVT 1496
Query: 4649 LEKLEDAMQAAVQYQDTLQAMFDWLDN-----TVIKLCTMPPVGTDLN--------TVKD 4695
++++E + + V ++ Q+ ++ KL + G +L T+
Sbjct: 1497 IQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILG 1556
Query: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD---------------------- 4733
L++ ++F+ + + Q + + + + +K + T+
Sbjct: 1557 HLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI 1616
Query: 4734 ------------RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4781
RD + L+ +E++ + RQ LE L + + L ++
Sbjct: 1617 TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1676
Query: 4782 WLTHTEELLDA-QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG 4840
WL E + + IS D +E EL L+N+V++ + + + L ++
Sbjct: 1677 WLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASK 1736
Query: 4841 DDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS 4900
DD ++ LE +++ W + Q +R LQS + + Q F + F + + S+L
Sbjct: 1737 DDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQ 1796
Query: 4901 ASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSV 4960
+ + L H + +++++K+ L +G L L GS + E
Sbjct: 1797 TTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSL--QGHLAKL-----GSLGRAEDL- 1846
Query: 4961 ALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN 5020
H++ K E+ EEA + Q +L LAE + AS L+
Sbjct: 1847 -------HLLQGKAEDCFQLFEEASQVVERRQLALSH------LAEFLQSHAS-----LS 1888
Query: 5021 TVLSQIEEHKVFANEVNAHRDQIIELD-----QTGNQLKFLSQKQDVVLIK-NLLVSVQS 5074
+L Q+ + N +N + +IE D Q L+ + D +L K + + S
Sbjct: 1889 GILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGS 1948
Query: 5075 RWEKVVQRS--------IERGRSL--------DDARKRAKQFHEAWKKLIDWLEDAESHL 5118
++ R+ +ER ++L D K F + ++L+ +ED E
Sbjct: 1949 SEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERT 2008
Query: 5119 DSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 5178
D E ++ +L + + L + + + +K + + ++D
Sbjct: 2009 DKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVA--FAPEVDRE 2066
Query: 5179 LGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL 5238
+ + WD E Q + + ++ + A+ L + +
Sbjct: 2067 INRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQE 2126
Query: 5239 DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR----DDTTWVKGQLQELSTRW 5294
DL H+ + ++ + + G+ L+ + D + VK ++ +W
Sbjct: 2127 DLKW-AFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKW 2185
Query: 5295 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 5354
V + RL +L + T + W + +P E + +L D
Sbjct: 2186 LDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNC---------VPQMAENISNL-D 2235
Query: 5355 THKEFMKKVEEKRVDV-NSAVAMGEVILAVCHPDCITTIKHW---ITIIRARFEEVLTWA 5410
H + ++E +V N A+ + E+ V +T + I A + L A
Sbjct: 2236 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2295
Query: 5411 KQHQQRLETALSELVANAELLEELL----AWIQWAETTLIQRDQEPIPQNIDRVKALIAE 5466
K+ + + L + A + +E+ + W E +L+ Q + + +VK + E
Sbjct: 2296 KEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKE 2355
Query: 5467 HQTFMEEMTRKQPDVDRVTKTYKRKNIE 5494
Q+ ++ Q +++ + + Y +E
Sbjct: 2356 LQSQQSNISSTQENLNSLCRKYHSAELE 2383
Score = 49.7 bits (117), Expect = 9e-05
Identities = 113/608 (18%), Positives = 233/608 (38%), Gaps = 90/608 (14%)
Query: 4982 EEALNLATEFQNSLQEFIN-----------WLTLAEQSLNIASPPSLILNTVLSQIEEHK 5030
+E L F NS+Q F W+ E+ L A ++ + + + + K
Sbjct: 303 DEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ---MVESNLQDKYQSFK 359
Query: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
F + R QI L Q ++ LS Q +V + W++V R + L
Sbjct: 360 HFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALV---------KQSWDRVTSRLFDWHIQL 410
Query: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK----IKLQLSKHKEFQKTLG 5146
D K + WL AE L E+ + ++ I+ +L +HK+ +
Sbjct: 411 D------KSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD 464
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 5206
+ + RT R++ + P+ L ++ +++ V S E L
Sbjct: 465 AHKRAFHEIYRT-RSVNGIPVPPDQ-------LEDMAERFHFVSSTS--------ELHLM 508
Query: 5207 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF---QKELGKRTGTVQ 5263
+F++ L+ L E +L +G + V L+ + F K + T Q
Sbjct: 509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568
Query: 5264 VLKRSGRELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 5321
+LK++ + + S ++ V + E + +W + S +S LE+ + + + +T
Sbjct: 569 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628
Query: 5322 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVE---EKRVDVNSAVAMGE 5378
V L WL +AE+ L + +E + K+F + + ++ +N A G
Sbjct: 629 VASLQAWLEDAEKML-------NQSE------NAKKDFFRNLPHWIQQHTAMNDA---GN 672
Query: 5379 VILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI 5438
++ C +K + ++ R+ E+ KQ+ Q E+ + + + +
Sbjct: 673 FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTL 727
Query: 5439 QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHA 5498
T ++ EP+ + VK LI + +E++ ++ P +D K + H
Sbjct: 728 SAFATEAHKKLSEPLEVSFMNVKLLIQD----LEDIEQRVPVMDAQYKIITK----TAHL 779
Query: 5499 PFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5558
E + G++ + + + E +P + + QQ+ + E ++++
Sbjct: 780 ITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYES----QQLLIPLEELEKQMTSFY 835
Query: 5559 DRLEELKE 5566
D L ++ E
Sbjct: 836 DSLGKINE 843
>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
Length = 3062
Score = 316 bits (810), Expect = 4e-85
Identities = 175/447 (39%), Positives = 281/447 (62%), Gaps = 19/447 (4%)
Query: 3 KGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALI 62
+GL+D DTG+ LLE+Q+++SGLI+PE + L++ + LI+ Q+ QL+EL A +I
Sbjct: 1249 RGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEII 1308
Query: 63 SRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLIS 122
S + + P V++A+ + +I+E++ +K+LE L+TG + + + L++AF Q L+S
Sbjct: 1309 SAASPTTIP--VLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVS 1366
Query: 123 AWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKS 182
+ L S + K+LIDP T+EK+ L+D++QR + + +G LLPV+ GG ++LK
Sbjct: 1367 SALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKC 1426
Query: 183 GRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACA 242
GR +SI RA EGLIDR+ RLL AQL +GG+++ +G R+TVEEAVR +ID+D A +
Sbjct: 1427 GRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASS 1486
Query: 243 ILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPI 302
IL Q+QTGGII + +RLT+DEAV DL+ + AL++LE+ ++GL+WP SGEI P
Sbjct: 1487 ILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPT 1546
Query: 303 TDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICI 362
+ +L+Q +++ ELA+KIL+ RQ I AL++P +++++ A + GI+D + A+ LK+I +
Sbjct: 1547 SSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITL 1606
Query: 363 PDVMPHM----------------QLADSAEQNINPGAAVLPCSKSHPKATASQSENL-LF 405
PD MP + + S + V + T+ +++ L L
Sbjct: 1607 PDKMPDLGDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLS 1666
Query: 406 QLMTHSYINVQNGQRLLLLDKELMETL 432
LM +SY++ GQRLLL D +L E +
Sbjct: 1667 YLMINSYMDANTGQRLLLYDGDLDEAV 1693
Score = 107 bits (267), Expect = 4e-22
Identities = 75/297 (25%), Positives = 155/297 (52%), Gaps = 7/297 (2%)
Query: 908 GLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLI 967
G ID + L+V Q++ RGL++ + +RLL Q++ G+I + +A HGLI
Sbjct: 1231 GTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLI 1290
Query: 968 GEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDL 1027
E + +LK + +I + + I + A+ +IT + ++ E+ TG+ V
Sbjct: 1291 DEQILCQLKELSKAK--EIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIP 1348
Query: 1028 ISGQRLTLAEAKKEGLLTN----EAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESG 1083
+G++LTL +A ++ L+++ + + M ++DP V ++V++ + +G
Sbjct: 1349 ATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTG 1408
Query: 1084 QRYLEVIPFSDIKDGVS-DKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRL 1142
L V P + + + +++ +A G +D + ++L AQ +GG+I++ +G+R+
Sbjct: 1409 MWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRM 1468
Query: 1143 TLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMI 1199
T+ A+ E ++D + I ++QV GGI+ +R+T+ EA++ LI+ A ++
Sbjct: 1469 TVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLV 1525
Score = 106 bits (265), Expect = 6e-22
Identities = 92/397 (23%), Positives = 188/397 (47%), Gaps = 39/397 (9%)
Query: 778 SQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKET 837
S++ + L + + ++EKL DK I+G +D T + SV AV GL+D +T
Sbjct: 1204 SESLKQLQESQTSGDVKVEEKL-------DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
Query: 838 ATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRE 897
R+LE Q++ G+I + K + A + GL+ D+ L L++ SK ++
Sbjct: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLI---DEQILCQLKELSKAKE------- 1306
Query: 898 RLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLS 957
+I S + V+ ++ + ++ A+++L + G ++ +G +L+
Sbjct: 1307 -----------IISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLT 1355
Query: 958 VDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEV 1017
+ AF+ L+ L K+ +N+ + +P T E +SL ++ + + + V
Sbjct: 1356 LQKAFQQNLVSSALFSKVLERQNM-CKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPV 1414
Query: 1018 QAFTGNFVDLISGQRLTLAEAKKEGLLTNEA---VLSPGMMH-GIVDPENCRIVPYSELV 1073
+ G + L G+ +++ A EGL+ E +LS ++ G+++ + + + E V
Sbjct: 1415 RPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAV 1474
Query: 1074 KKCKIDIESGQRYLEV-IPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGG 1132
++ ID ++ L + I K LT+ +A+Q + +S L VLEAQ G
Sbjct: 1475 REGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVG 1534
Query: 1133 IIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNG 1169
+I +G+ +S+L+++L+ + ++++LNG
Sbjct: 1535 LIWPHSGEIFPTSSSLQQELITNEL-----AYKILNG 1566
Score = 104 bits (260), Expect = 2e-21
Identities = 102/414 (24%), Positives = 194/414 (46%), Gaps = 45/414 (10%)
Query: 666 KKEMLKKT------FLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLEL 719
KKE L + FLAK K + E +N + KT +E L S L+
Sbjct: 1158 KKEQLSEALQTIQLFLAKHGDKMTDEERN----ELEKQVKTLQESYN----LLFSESLKQ 1209
Query: 720 LEEATLN--VLSAQLLD---GGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQG 774
L+E+ + V + LD G + TG+ L + +A+ RG++ T ++L+E M G
Sbjct: 1210 LQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISG 1269
Query: 775 FFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLD 834
+ + ++ + GL+DE++L + KA ++ + T V DA+ ++
Sbjct: 1270 LISPELRKCFDLKDAKSHGLIDEQILCQLKELSKA-KEIISAASPTTIPVLDALAQSMIT 1328
Query: 835 KETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGR----D 890
+ A ++LE + TG ++ G+++++ A LV A +++ + K
Sbjct: 1329 ESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCT 1388
Query: 891 AEK----------TVRER----LISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVR 936
+EK T++E L+ ++ + G I ++++++ GL++RE R
Sbjct: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
Query: 937 LLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENIS 996
LL+ Q++ GG+I+ SG R++V+ A R G+I D A + + + I + ++
Sbjct: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQ-VQTGGIIQSNPAKRLT 1507
Query: 997 LPKAIKLDLITSDLKREIQEVQAFTGNFVDLI---SGQRLTLAEAKKEGLLTNE 1047
+ +A++ DLITS + E Q +V LI SG+ + + ++ L+TNE
Sbjct: 1508 VDEAVQCDLITSSSALLVLEAQR---GYVGLIWPHSGEIFPTSSSLQQELITNE 1558
Score = 95.9 bits (237), Expect = 1e-18
Identities = 97/401 (24%), Positives = 167/401 (41%), Gaps = 42/401 (10%)
Query: 750 EAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKA 809
+A+++ ++ A+K++E L T E LT ++ + L+ L VL
Sbjct: 1320 DALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNM 1379
Query: 810 ISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLG 869
++DP T S+ D V L + T +L + GG I LK G+ +S+ A+ G
Sbjct: 1380 CKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEG 1439
Query: 870 LVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLL 929
L+D + RL+S Q+ + GLI+ +S +TV +++ G++
Sbjct: 1440 LID--------------------RETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVI 1479
Query: 930 EREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNP 989
+R+ A +LT QV GGII RL+VD A + LI A + + + I+ P
Sbjct: 1480 DRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIW-P 1538
Query: 990 ETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEA- 1048
+ E +++ +LIT++L +I + S Q + L AK+ G++ N
Sbjct: 1539 HSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
Query: 1049 -----VLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKV 1103
+ P M + D E C+ + CK + Y + D+ DG
Sbjct: 1599 SILKNITLPDKMPDLGDLEACKNA--RRWLSFCKFQPSTVHDYRQE---EDVFDGEEPVT 1653
Query: 1104 LTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTL 1144
S+ T K+ + +D TG+RL L
Sbjct: 1654 TQTSE----------ETKKLFLSYLMINSYMDANTGQRLLL 1684
Score = 88.2 bits (217), Expect = 2e-16
Identities = 70/285 (24%), Positives = 126/285 (44%), Gaps = 9/285 (3%)
Query: 172 QLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVR 231
++ G + +G +S+F+AV GLID +RLLE QL G++ P +++A
Sbjct: 1227 KVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKS 1286
Query: 232 HNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGL 291
H LID+ + C L + II + + + +A++ ++ +A+ +LE L S L
Sbjct: 1287 HGLIDEQILCQ-LKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
Query: 292 LWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDR 351
+ P +GE L + A +Q +VS+ L K+L + K L P T+E +S ++ L
Sbjct: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
Query: 352 DLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHS 411
+ L + Q ++L + + L QL++
Sbjct: 1406 NTGMWLLPV-------RPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGG 1458
Query: 412 YINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTP 456
IN +GQR + +++ + E + RD + V+ G Q P
Sbjct: 1459 LINSNSGQR-MTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNP 1502
Score = 74.3 bits (181), Expect = 3e-12
Identities = 60/294 (20%), Positives = 126/294 (42%), Gaps = 42/294 (14%)
Query: 101 FSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVH 160
++L SE+ L+E+ G + V E + ID T E + + + R ++
Sbjct: 1199 YNLLFSESLKQLQESQTSGDVK-----VEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
Query: 161 QESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQV------------------- 201
++G +LL + + G++S + + + A GLID Q+
Sbjct: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
Query: 202 ------------------TVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAI 243
+++LE L G +V P TG +LT+++A + NL+ + +
Sbjct: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
Query: 244 LIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPIT 303
L RQ +ID T +++++ + V + + +L G + + G + I
Sbjct: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISIL 1433
Query: 304 DALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNL 357
A +G++ E ++LS + L + + ++ ++A+ G++DRD A+++
Sbjct: 1434 RAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSI 1487
Score = 68.6 bits (166), Expect = 2e-10
Identities = 193/1020 (18%), Positives = 396/1020 (38%), Gaps = 147/1020 (14%)
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
K++LLDQ L+ + + ++LNW+ E++ +L + L E
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT------------EWGSDLPSVESH 311
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEV-------LLIQEKLDGIKTRYADITVTSSKALRT 4100
+ KNV +AI+ ++ LK+ E+ L EKL ++++YA + TS R
Sbjct: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
Query: 4101 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 4160
L+ ++ +T E + WL E EEE + S I + + EL +E+ +
Sbjct: 372 LDTLHNFVSR--ATNELI--WLNEKEEE-EVAYDWSERNTNIARKKDYHAELMRELDQKE 426
Query: 4161 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 4220
+ +V E++ LL L AR ++ + Q+ + +Q Q
Sbjct: 427 ENIKSVQEIAEQLL-LENHPARLTIEAYRAAMQTQWSWI--------------LQLCQCV 471
Query: 4221 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI----DIIRHK-DSMDEL 4275
EQ A+ A +R +D + ++ SI D+++ + +EL
Sbjct: 472 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
Query: 4276 FSHRSEIFGTCGEEQKTVLQEK---TESLIQQYEAISLLNSERYARL-----ERAQVLVN 4327
++S I G+ KT++Q K ++ ++ I + R + + + N
Sbjct: 532 LQYKSTIANLMGKA-KTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANN 590
Query: 4328 QFWETYEELSPWIEETR--ALIAQLPSP---AID-HEQLRQQQEEMRQL-------RESI 4374
++ +SP E ++ +P P A+D ++ QQ + + L +S+
Sbjct: 591 SHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSV 650
Query: 4375 AEHKPHIDKLLKIGPQ----LKELNPEEGEMVEEKYQKAENMY---------------AQ 4415
I+++ +I +K + P E + V Q + Q
Sbjct: 651 VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
Query: 4416 IKEEVR------QRALALDEAVSQSTQITEFH-DKIEPMLETLENLSSRLRMPPLIPAEV 4468
+++EV Q L E Q + + ++ + LEN RL P E
Sbjct: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLER 770
Query: 4469 DKIREC---ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4525
D + E I++ + ELE+L+ + + EE ++ + + ++ +L+ +
Sbjct: 771 DDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVV 827
Query: 4526 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIK 4585
+ + + + ++D L+ + A +K + + + E+ D + I+
Sbjct: 828 LQNMNQVYSMSST----YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIE 883
Query: 4586 QQVEAAETIKEETD-------GLHEELEFIRILGADLIFACGETEKPEV--RKSIDEMNN 4636
+ + + E D L +EL+ + + ++ E + ++ D++
Sbjct: 884 NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943
Query: 4637 AWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL---DNTVIKLCTMPPVGTDLNTV 4693
W+N++ RL LE ++ Y+DT + DW+ + T K+ P + T+
Sbjct: 944 RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTL 1001
Query: 4694 KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE 4753
QLN+ K E+ +Q +M++ E T +D + +T + + ++ +
Sbjct: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAE-----QYSATVKDYELQTMT-YRAMVDSQQK 1055
Query: 4754 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELL----DAQRPISGDPKVIEVELAK 4809
R+ A L + +F + +T + + D+ + + + K +E E K
Sbjct: 1056 SPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-KK 1114
Query: 4810 HHVLKNDVLAH-----QATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQ 4862
HV K L T++ KAG + + ++ S+ + +L Q + L
Sbjct: 1115 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1174
Query: 4863 K-----TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD 4917
K T+E +L+ ++ Q E + L + QL S+ +G + E+LD
Sbjct: 1175 KHGDKMTDEERNELEKQVKTLQ------ESYNLLFSESLKQLQESQTSGDV--KVEEKLD 1226
Score = 65.1 bits (157), Expect = 2e-09
Identities = 196/1101 (17%), Positives = 410/1101 (37%), Gaps = 213/1101 (19%)
Query: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
+SSLL + + + + + ++ LL + E++ L+ + S D+
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGS------------------DL 305
Query: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEK----ESSLKK 2653
+S LE + V R +E +S+ + + K++E+ Q L L EK ES K
Sbjct: 306 PSVESHLE-NHKNVHRAIEEFESS---LKEAKISEI-QMTAPLKLTYAEKLHRLESQYAK 360
Query: 2654 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL------------ 2701
LL + E L F+ + L N+ +++ + + N+
Sbjct: 361 LLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR 420
Query: 2702 EMEDQQENLDTLEHLVTEL-------------------SSCGFALDLCQHQDR------- 2735
E++ ++EN+ +++ + +L + + L LCQ ++
Sbjct: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTA 480
Query: 2736 ---VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792
N K+ T+ + +K+ + SC ++ KL Q+ ++E E + T
Sbjct: 481 YFEFFNDAKEATDYLRNLKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIA 539
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME----ITAPDSQGKTGSIL 2848
+ K I LK D K ++ + C +E I + + A +S ++
Sbjct: 540 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 599
Query: 2849 PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2908
G+ + T + D+++ ++ Q +L E H
Sbjct: 600 SPTGNEAMVPSVCFTVPPPNKEAVDLAN-------------RIEQQYQNVLTLWHESHIN 646
Query: 2909 ANSVLQW--LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL 2966
SV+ W L ++ + +++ + S T Q SN L ++ + + +
Sbjct: 647 MKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSN---LQSRFEDFLEDSQESQVF 703
Query: 2967 AGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 3026
+G +T + + QE L S A + + EES +L + +LR
Sbjct: 704 SGSDITQLEKEVNVCKQYYQELLKS----------AEREEQEESVYNLYISEVRNIRLRL 753
Query: 3027 WLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDV 3086
E L+ + PL D + F + E E +++ E+L + G +T +
Sbjct: 754 ENCEDRLIRQIRTPLERD------DLHESVFRITEQEKLKKELERLKDDL-GTITNKCEE 806
Query: 3087 SLSTSQVQKELQSINQKWVELTDKLNS----RSSQIDQA-----IVKSTQYQELL----- 3132
S + + ++ + + +N S+ ID+ ++K+TQ E L
Sbjct: 807 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 866
Query: 3133 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 3192
L E+ + + ++++ IST +KQ E E R L+ E+++A+ + DE+
Sbjct: 867 TKLCEEEAVIADKNNIENLIST----LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
Query: 3193 LIGEQYLK-DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 3251
E+ L D K++ + + Q + +R+ L+ S + ++ + L W+
Sbjct: 923 TYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ- 981
Query: 3252 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 3311
++E Q ++QEN+ E +
Sbjct: 982 -------------QVETTQRKIQENQP-----------------------------ENSK 999
Query: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 3371
TL QL + K E+ K QS++ +C + A++Y V+D
Sbjct: 1000 TLATQLNQQKMLVSEIEMK----QSKMDECQKYAEQYSATVKD----------------- 1038
Query: 3372 TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNM 3431
E + +AM++ +K + S+AD++I + Q +
Sbjct: 1039 ------YELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI 1092
Query: 3432 DAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL-- 3489
+ L+ + + + +E E K ++K V L+ + G S + +
Sbjct: 1093 KFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1152
Query: 3490 EKLRAQQEVL-QALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF-------- 3540
E++ ++E L +AL+ +L + ++ + ++L Q + Q+ +
Sbjct: 1153 EEISTKKEQLSEALQTIQLFLAKHGDKMTDE-----ERNELEKQVKTLQESYNLLFSESL 1207
Query: 3541 LEVKQRVNSGCVMMENKLEGI 3561
++++ SG V +E KL+ +
Sbjct: 1208 KQLQESQTSGDVKVEEKLDKV 1228
Score = 64.3 bits (155), Expect = 3e-09
Identities = 188/1017 (18%), Positives = 387/1017 (38%), Gaps = 155/1017 (15%)
Query: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
++ L+K+ QN +++ +DL +WV + + L RT SDL
Sbjct: 259 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 305
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149
++ ++N + +++ E ++E K+S ++TA EKLH+ + QY L
Sbjct: 306 PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 362
Query: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201
+R ++ L+ V+ A + E E+ + A + +E I D+ +
Sbjct: 363 NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 422
Query: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258
Q N+ +++++ L + A T + Y Q Q C+ ++ +E +
Sbjct: 423 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 482
Query: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317
+ F N E L+ ++ +YS + S +L+ VQ +
Sbjct: 483 EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 526
Query: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368
E ++ LQ + + +++ ++ + P +K + + I
Sbjct: 527 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
Query: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421
SH+ + ++ +G + + F KE ++ N ++ + ++ T H
Sbjct: 587 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 642
Query: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480
SH+NM + +H N D ++A + A+++ +L PG Q+ L+ +
Sbjct: 643 -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 687
Query: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540
E+ E + DI ++E E ++ QE S AER
Sbjct: 688 SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 733
Query: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593
Q +SV S +++I +N E + + + + + ++ L ++ KL
Sbjct: 734 -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 786
Query: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649
K+++ R K L T + F + A S++ L+ +L V Q Q+ +K
Sbjct: 787 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 846
Query: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709
++ +L + E L + + + ++A N +I + +++ E++++++
Sbjct: 847 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 902
Query: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
LE + + + LD H+++ L + + + + R +D
Sbjct: 903 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 962
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
+ L +R W+++ E + K E Q E+ K+L + LV E
Sbjct: 963 GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1014
Query: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874
I K + ++ T D + +T + V S S V I +
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 2875 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2934
D+ +Y L ++ + + L R+EE K E KE V K+ + +
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE-----EKKEHVEKAKELQKWVSN 1129
Query: 2935 -TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELN 2990
++T+K ++ K ++ + +S +I KE L+ L T K EE N
Sbjct: 1130 ISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1186
Score = 63.5 bits (153), Expect = 6e-09
Identities = 41/168 (24%), Positives = 76/168 (45%), Gaps = 1/168 (0%)
Query: 706 GREI-FLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVK 764
GR I L +H + E +LSAQLL GG+ + +GQ++ + EA+ G++ TA
Sbjct: 1427 GRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASS 1486
Query: 765 LMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSV 824
++ G S + LT +E + L+ VL A + G++ P + +
Sbjct: 1487 ILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPT 1546
Query: 825 KDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVD 872
++ L+ E A +IL + + + + + + A LG++D
Sbjct: 1547 SSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIID 1594
Score = 62.8 bits (151), Expect = 1e-08
Identities = 198/1074 (18%), Positives = 398/1074 (37%), Gaps = 197/1074 (18%)
Query: 4666 LQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFK--VEVYQQQIEMEKLNHQGEL 4723
+Q + +W+D ++L G+DL +V+ L K +E ++ ++ K++
Sbjct: 282 VQDLLNWVDEMQVQL-DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340
Query: 4724 MLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4783
K T E H E+ K+ + E L L F + WL
Sbjct: 341 APLKLT-----------YAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWL 389
Query: 4784 THTEELLDAQRPISGDPKVIEVELAK----HHVLKNDVLAHQATVETVNKAGNELLESSA 4839
EE ++ D +A+ H L ++ + +++V + +LL +
Sbjct: 390 NEKEE-----EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH 444
Query: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS--EIEDFLLELT---R 4894
++ + AM W +LQ + EQ ++ + F+ E D+L L +
Sbjct: 445 -PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 503
Query: 4895 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSG 4953
+ S L + +E ++ EL + T L+ K + ++ L +S
Sbjct: 504 RKYSCDRSSSIHKLEDLVQESMEEKEELLQY----KSTIANLMGKAKTIIQLKPRNSDCP 559
Query: 4954 SKTEQSVALL-----------------------EQKWHVVSSKMEERKSKL--------- 4981
KT + + KW V+S E
Sbjct: 560 LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPN 619
Query: 4982 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 5041
+EA++LA + Q++ N LTL +S + + + NE++ R
Sbjct: 620 KEAVDLANRIE---QQYQNVLTLWHES-----------HINMKSVVSWHYLINEIDRIRA 665
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER----GRSLDDARKRA 5097
+ +K + + ++ NL QSR+E ++ S E G + K
Sbjct: 666 SNVA------SIKTMLPGEHQQVLSNL----QSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 5098 ---KQFHEAWKKLIDWLEDAESHLDS--------ELEISNDPDKIKLQLSKHKEFQKTLG 5146
KQ+++ K + E ES + L + N D++ Q+ E
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLE------ 769
Query: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ--------- 5197
+ ++++ R + E+ L ++ ++L + LG + +K + ++
Sbjct: 770 -RDDLHESVFR----ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824
Query: 5198 ----HKLEEALLFSGQFMDALQAL---------VDWLYKV-EPQLAEDQPVHGDLDLVMN 5243
+ + S ++D L+ + + L K+ E +L E++ V D + + N
Sbjct: 825 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 884
Query: 5244 LMDAHKVFQKELGKRTGTVQVL-------KRSGRELIENSRD---DTTWVKGQLQELSTR 5293
L+ K ++ E+ ++ L K E+ + ++ D W K + +L R
Sbjct: 885 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 944
Query: 5294 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSL 5352
W V ++ LE K + +RDT H L +W+ + E T R + P++++ L +
Sbjct: 945 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1004
Query: 5353 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQ 5412
++ K + ++E K+ ++ E A + T+ + RA +
Sbjct: 1005 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY-----RAMVDS------- 1052
Query: 5413 HQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 5472
QQ+ + ++A+L+ + ++ T L+ + I D +K L E ++ E
Sbjct: 1053 -QQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1111
Query: 5473 EMTRKQPDVDRVTKTYK-RKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNP 5531
E K+ V++ + K NI T ++ + G+ PP SE +
Sbjct: 1112 E---KKEHVEKAKELQKWVSNISKT----LKDAEKAGK-------PPFSKQKISSEEIST 1157
Query: 5532 RINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVM 5591
+ QLS Q + L + K+ D EE E +K ++ + + +
Sbjct: 1158 KKEQLSEALQTIQLFLAKHGDKMTD-----EERNEL---------EKQVKTLQESYNLLF 1203
Query: 5592 -DFFRRIDKDQ-DGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY 5643
+ +++ + Q G + +E +D ++A T E V +F G IDY
Sbjct: 1204 SESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGE---VLSVFQAVLRGLIDY 1254
Score = 60.1 bits (144), Expect = 6e-08
Identities = 192/1080 (17%), Positives = 404/1080 (37%), Gaps = 202/1080 (18%)
Query: 3114 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 3173
+SS +DQ + + + +QDL V + +L S P +V+ LE + +
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLP-SVESHLENHKNVHRAI 322
Query: 3174 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN---RLQA 3230
E+ + +KEA+ I E + LK T A L LE A +N +
Sbjct: 323 EEFESSLKEAK---------ISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQER 370
Query: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
L + F WL++K+ ++ S + + + + E + L+Q +
Sbjct: 371 HLDTLHNFVSRATNELIWLNEKEEEEVAY-DWSERNTNIARKKDYHAELMRELDQKEENI 429
Query: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEEL----------------------- 3327
+ + E LLL P + T++ ++ W +
Sbjct: 430 KSVQEIAEQLLLENHPA--RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
Query: 3328 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA 3387
+K+ D LKD +Q+ KY + +ED + E + E L
Sbjct: 488 AKEATDYLRNLKDAIQR--KYSCDRSSSIHKLEDLVQESME--------EKEELLQYKST 537
Query: 3388 MLNEVEKRRSLLEILNSAADILINSS----------EADEDGIRDEKAGINQNMDAVTEE 3437
+ N + K ++++++ +D + +S + + +D++ + N +
Sbjct: 538 IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 597
Query: 3438 LQAKTGSL--------------EEMTQRLREFQESFKNI----------EKKVEGAKHQL 3473
+ + TG+ +E ++ ++N+ K V + +
Sbjct: 598 VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 657
Query: 3474 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQV-DYLRNFTQGLVEDAPDGSDASQLLHQ 3532
D + + ++ Q+VL L+ + D+L + + V GSD +QL +
Sbjct: 658 NEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFS---GSDITQLEKE 714
Query: 3533 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHC-RVREMFSQLADLDDELDGMGAIGRD 3591
V +Q + E+ + E + E + + VR + +L + +D L
Sbjct: 715 VNVCKQYYQELLKSAER-----EEQEESVYNLYISEVRNIRLRLENCEDRL--------- 760
Query: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3651
I +R L + + E+ R +E+ +L LK +L + +C +
Sbjct: 761 -------IRQIRTPLERD-------DLHESVFRITEQEKLKKELERLKDDLGTITNKCEE 806
Query: 3652 LTERGKAR------QEQLELTLGRVEDFYR-------KLKGLNDATTAAEEAEALQWVVG 3698
+ A + +L + L + Y KLK +N + AEAL +
Sbjct: 807 FFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYE 866
Query: 3699 TEVEIINQQLAD---------------FKMFQKEQV-DPLQMKLQQVNGLGQGLIQS-AG 3741
T++ +AD ++ +K QV L+ +LQ+ + + ++
Sbjct: 867 TKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKE 926
Query: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLAD---T 3798
+D D + +++ RW ++ ++ R+ L+ ++D PL W+ T
Sbjct: 927 RDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETT 986
Query: 3799 EELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858
+ I +P ++ K + Q+ +QK+L ++ +++ +D Q + SA + D E
Sbjct: 987 QRKIQENQPENS--KTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQ 1042
Query: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
T ++ + K+ ++++++ L Q E + + + ++ + G
Sbjct: 1043 TMTYRAM----VDSQQKSPVKRRRMQSSADLIIQ--EFMDLRTRYTALVTLMTQYIKFAG 1096
Query: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQG----VLSEKIDSL 3974
+++++ K+LEE+ + H + K ++S AE+ +KI S
Sbjct: 1097 DSLKRLEEE---EKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS- 1152
Query: 3975 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLH 4034
+ K L +AL +LF LA+ DK++ + ++ V
Sbjct: 1153 --------EEISTKKEQLSEALQTIQLF----------LAKHGDKMTDEERNELEKQVKT 1194
Query: 4035 RQHADHLALNEEI-----------VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083
Q + +L +E + V ++ +D+ I + QTTGE + + Q L G+
Sbjct: 1195 LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVI---AGTIDQTTGEVLSVFQAVLRGL 1251
Score = 56.6 bits (135), Expect = 7e-07
Identities = 108/547 (19%), Positives = 223/547 (40%), Gaps = 95/547 (17%)
Query: 1805 EHDEKLVS-YLSLLRNIEMRTKQIQ---------PLELN-LAELQDLLCQAKVLERELK- 1852
E +E + + Y+S +RNI +R + + PLE + L E + + + L++EL+
Sbjct: 733 EQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELER 792
Query: 1853 ---DLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHF 1909
DL T+ ++ E +Q S L + ++ + S+ D + L
Sbjct: 793 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVL 852
Query: 1910 QNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKN----LILNSKGSNSEIDVDSLNLCLQQ 1965
+N E L E +L + A + +KN LI K SE+D Q
Sbjct: 853 KNTQAAEALVKL-----YETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR-----QV 902
Query: 1966 YEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTA 2025
+ L+ + + KA D + F + +DL +++ ++L +Q++ Q
Sbjct: 903 FHALEDELQKAKAISD------EMFKTYKERDLDFDWHKEKA---DQLVERWQNVHVQID 953
Query: 2026 AQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLS 2085
++ L+G + K+L+ ++T H L+D V +R + +Q ++ +
Sbjct: 954 NRLRDLEG---------IGKSLKYYRDTYHP-LDDWIQQVETTQRKIQENQPENSKTLAT 1003
Query: 2086 ALQKNQSDLKDLQ------DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLH 2139
L + + + +++ D+ Q A ++ VKD E + + ++ + ++ +
Sbjct: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRM 1063
Query: 2140 QAKEQY---EALQEETR------VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDAL 2190
Q+ E + TR + + ++ A S + E E+ +E E+ +K L
Sbjct: 1064 QSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL 1123
Query: 2191 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 2250
WV+++ + L E+ K K
Sbjct: 1124 QKWVSNISKT-------LKDAEKAGKPPFSK-------------------------QKIS 1151
Query: 2251 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK 2310
+E+ ++++ A Q+ Q FL +HG +T EE+ L++++ L+E Y+ ++S +L+
Sbjct: 1152 SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQ 1211
Query: 2311 QVQTLQD 2317
+ QT D
Sbjct: 1212 ESQTSGD 1218
Score = 51.6 bits (122), Expect = 2e-05
Identities = 139/730 (19%), Positives = 286/730 (39%), Gaps = 158/730 (21%)
Query: 1917 KTKVLNQHTQ----LEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQP 1972
KT + +H Q L+ R +D + S + E +V N+C Q Y++L +
Sbjct: 672 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVCKQYYQELLKS 728
Query: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032
AER+ Q +++ +ISE LRL N R + I +T + D L
Sbjct: 729 -AEREEQEESV---YNLYISE--------VRNIRLRLENCEDRLIRQI--RTPLERDDLH 774
Query: 2033 GHLQQM-EQEALVKTLQKQQN---TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQ 2088
+ ++ EQE L K L++ ++ T + E+ S +A A T + +L+ +
Sbjct: 775 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFS------QAAASSSVPTLRSELNVVL 828
Query: 2089 KNQSDLKDLQDDIQNRATSFATVVKDI---EGFMEENQTKLSPRE--------------- 2130
+N + + + ++ + V+K+ E ++ +TKL E
Sbjct: 829 QNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST 888
Query: 2131 LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETE----KSKA---------- 2176
L R ++ + ++ + AL++E + A+ +E + +++ + K KA
Sbjct: 889 LKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV 948
Query: 2177 --------------AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222
K L + L DW+ V ++ ++ N P + L +
Sbjct: 949 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008
Query: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282
+ ++ + K+D +C+ ++ + +++ L T + +A +D +P
Sbjct: 1009 KMLVSE----IEMKQSKMD-ECQKYAEQYSATV---KDYELQTMTYRAMVDSQ--QKSPV 1058
Query: 2283 EQQMLQ-------QKLGELKEQYSTSLAQSEAELK-----------QVQTLQDELQKFLQ 2324
+++ +Q Q+ +L+ +Y+ + +K + ++L++E ++ ++
Sbjct: 1059 KRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVE 1118
Query: 2325 DHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLR--------F 2376
KE + W+ K L++ K G P +Q SE++ + K L F
Sbjct: 1119 KAKELQKWVSNISKTLKDAEKAGKPP------FSKQKISSEEISTKKEQLSEALQTIQLF 1172
Query: 2377 VTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQY 2436
+ G K+ D E N ++ ++K E Y L S+ L Q
Sbjct: 1173 LAKHGDKMTDEER------------NELEKQVKTLQESYNLLFSES----------LKQL 1210
Query: 2437 HQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 2496
+ Q S D E ++K+++ T+ G E L+ + + L ++ + L
Sbjct: 1211 QESQTSGD------VKVEEKLDKVIAGTIDQTTG---EVLSVFQAVLRGLIDYDTGIRLL 1261
Query: 2497 QKVARDIMEIEGEPAPDHRHVQETTDSILSH---FQSLSYSLAERSSLLQKAIAQSQSVQ 2553
+ + I G +P+ R + D+ SH + + L E S + A S +
Sbjct: 1262 ETQ----LMISGLISPELRKCFDLKDA-KSHGLIDEQILCQLKELSKAKEIISAASPTTI 1316
Query: 2554 ESLESLLQSI 2563
L++L QS+
Sbjct: 1317 PVLDALAQSM 1326
Score = 51.2 bits (121), Expect = 3e-05
Identities = 63/304 (20%), Positives = 135/304 (44%), Gaps = 38/304 (12%)
Query: 640 QVQVKKTLGIK-LELKSETDGNVHPLDKKEM-LKKTFLAKDDHKESQEAQNIAGGSMMMS 697
Q + +++ IK LE+ T V P +++ L+K F QN+ S + S
Sbjct: 1324 QSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAF-----------QQNLVS-SALFS 1371
Query: 698 EKTDEEDSGREIFLSCSHP----LELLEEATLN------VLSAQLLDGGIFHEQTGQKLL 747
+ + ++ +++ C+ +++++ +TL +L + +GG + G+ +
Sbjct: 1372 KVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNIS 1431
Query: 748 LNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMAD 807
+ A G++ T +L+ + G +S + + +T EE + EG++D ++L
Sbjct: 1432 ILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQ 1491
Query: 808 KAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLAST 867
G++ +V +AV L+ +A +LE Q G+I G ++ T +S
Sbjct: 1492 VQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSG-EIFPTSSSL 1550
Query: 868 LGLVDVADQPELINLEKASKGRDAEKTVRERLISLQM-ETTGLIDPDSKAPLTVVQSIDR 926
Q ELI E A K + R+++ +L + E++ +I D+ L ++ +
Sbjct: 1551 --------QQELITNELAYKILNG----RQKIAALYIPESSQVIGLDAAKQLGIIDNNTA 1598
Query: 927 GLLE 930
+L+
Sbjct: 1599 SILK 1602
Score = 39.3 bits (90), Expect = 0.12
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363
K S L+Q L + E+ V LL W+ E + L R D +++S ++ HK + +
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLD-RTEWGSDLPSVESHLENHKNVHRAI 322
Query: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSE 5423
EE + A + E+ + T + + +++ ++L ++ ++ L+T L
Sbjct: 323 EEFESSLKEA-KISEIQMTA---PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT-LHN 377
Query: 5424 LVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDR 5483
V+ A L W+ E + D NI R K H M E+ +K+ ++
Sbjct: 378 FVSRA---TNELIWLNEKEEEEVAYDWSERNTNIARKKDY---HAELMRELDQKEENIKS 431
Query: 5484 VTKTYKRKNIE 5494
V + ++ +E
Sbjct: 432 VQEIAEQLLLE 442
Score = 37.7 bits (86), Expect = 0.34
Identities = 99/503 (19%), Positives = 204/503 (40%), Gaps = 69/503 (13%)
Query: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARY 3978
T+ K+++++ R K I N + S+ +L S E V+ + ++ + +
Sbjct: 781 TEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRS--ELNVVLQNMNQVYSMS 838
Query: 3979 SEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK-----LSSVFVKDFKQDVL 4033
S D+ +L + L E ++ A + DK L S +K ++ +V
Sbjct: 839 STYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIST-LKQWRSEVD 897
Query: 4034 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI---QEKLDGIKTRYADI 4090
++ H AL +E+ K D+ K T E L +EK D + R+ ++
Sbjct: 898 EKRQVFH-ALEDELQKAKAISDEMFK--------TYKERDLDFDWHKEKADQLVERWQNV 948
Query: 4091 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQ-QRQ 4149
V LR LE + ++ TY L W+++VE T +I + Q +
Sbjct: 949 HVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVE----------TTQRKIQENQPENS 998
Query: 4150 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209
K L ++ + ++++ + E+ ++ ++ A + S + Y+L + T VD
Sbjct: 999 KTLATQLNQQKMLVSEI-EMKQSKMDECQKYAEQ-----YSATVKDYELQTMTYRAMVDS 1052
Query: 4210 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHK 4269
+ + ++ + +AD + + + + AL T Q K F+ D ++
Sbjct: 1053 QQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL---------VTLMTQYIK-FAGDSLKRL 1102
Query: 4270 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS--LLNSERYAR--LERAQVL 4325
+ ++ EE+K EK + L + IS L ++E+ + + ++
Sbjct: 1103 EEEEKSL-----------EEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1151
Query: 4326 VNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL 4385
+ E+LS ++ + +A+ D E+ + +++++ L+ES + + L
Sbjct: 1152 SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER-NELEKQVKTLQES---YNLLFSESL 1207
Query: 4386 KIGPQLKELNPEEGEMVEEKYQK 4408
K QL+E VEEK K
Sbjct: 1208 K---QLQESQTSGDVKVEEKLDK 1227
Score = 36.2 bits (82), Expect = 1.00
Identities = 50/224 (22%), Positives = 101/224 (45%), Gaps = 16/224 (7%)
Query: 5211 MDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSG 5269
M +Q L++W+ +++ QL D+ G DL V + ++ HK + + + +++ K S
Sbjct: 279 MKFVQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS- 335
Query: 5270 RELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWL 5329
E+ + T+ + +L L +++ + S +++ L+ V R T ++ WL
Sbjct: 336 -EIQMTAPLKLTYAE-KLHRLESQYAKLLNTSRNQERHLDTL--HNFVSRATNELI--WL 389
Query: 5330 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 5389
+E E+ +T + D H E M+++++K ++ S + E +L HP +
Sbjct: 390 NEKEEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448
Query: 5390 TTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEE 5433
T I RA + +W Q Q +E + E A E +
Sbjct: 449 T-----IEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFND 487
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 270 bits (690), Expect = 3e-71
Identities = 613/3315 (18%), Positives = 1281/3315 (38%), Gaps = 365/3315 (11%)
Query: 2382 QKVLDMENSFKE--GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSH---LNMLLGQY 2436
QK L+ + K+ ++ L + ++ A R + L+ + L + L ++L
Sbjct: 8 QKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI 67
Query: 2437 HQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL-ATTKQLQEELAEHQVPVEK 2495
+ + A AW A + + +L T+ + + +L A T++LQ + V
Sbjct: 68 EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQ-----YLTSVYC 122
Query: 2496 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2555
+K+++ + E+ R +E I Q+L Q A + +
Sbjct: 123 TEKMSQQVAELG-------RETEELRQMIKIRLQNL-----------QDAAKDMKKFEAE 164
Query: 2556 LESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
L+ L ++ + + L +V LS ++E L+ L ++ K ++A + +
Sbjct: 165 LKKLQAALEQAQATLTSPEVGRLS---LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALR 221
Query: 2616 ETADSTTAAVLQG---KLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM 2672
D + L +L E + R + +QQ + ++ + Q E +E LQQ +
Sbjct: 222 IPEDVVASLPLCHAALRLQEEASRLQHTAIQQC---NIMQAAVVQYEQYEQEMKHLQQLI 278
Query: 2673 ENKSRMLASGNQPDQDITHFFQQI---QELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2729
E R + +I QI +EL +++ QE + +L S C
Sbjct: 279 EGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN------SKC------ 326
Query: 2730 CQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTE 2789
++ ++ + TV E E A ++ E + T G
Sbjct: 327 -----KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRC---H 378
Query: 2790 TSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLI--MEITAPDSQGKTGSI 2847
T +S E E S + + + N + +++ ++A Q I
Sbjct: 379 TLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKI 438
Query: 2848 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2907
PS +S ++ + D+ +E L V+ E+Q +L L R ++
Sbjct: 439 HPSTSAS----QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
Query: 2908 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2967
S+ +E+ E L SP + ++Q ++A + E+ +I +++ +LA
Sbjct: 495 SLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLA 549
Query: 2968 GLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR-----------QLEESASHLAC 3016
LV+ + +Q L ER + + + QLEE A
Sbjct: 550 EELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQAL 609
Query: 3017 --FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
++ +L WL+ + + +P + AQ Q ML E E + +L+
Sbjct: 610 QRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSV 669
Query: 3075 AAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 3133
+ +L G Q+ +L+ + +EL L+ + Q ++ T ++
Sbjct: 670 HNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-----QLNMQGTAQEKEES 724
Query: 3134 DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVL 3193
D+ Q VQ ++ QQ + + + + +LEQ E+ E ++L ++
Sbjct: 725 DVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ---ELAEQKSLLRSVASR 778
Query: 3194 IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQ 3253
GE+ L ++ A G A ++ + L L + D++R +
Sbjct: 779 -GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 827
Query: 3254 SQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVP------PG 3307
+ S K + LQ+ L++ +E +V+ + LL VP P
Sbjct: 828 QE------FSTKQKLLQNVLEQEQE------------QVLYSRPNRLLSGVPLYKGDVPT 869
Query: 3308 EEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAK 3365
++K + + L L +EE+S ++ A RQS + QK V W++D + +
Sbjct: 870 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKLYDGVSATSTWLDDVEER 924
Query: 3366 MSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKA 3425
+ + L P + E+ L + + ++++ ++ + + + D I D
Sbjct: 925 LF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLG 983
Query: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS 3485
+ + + + + ++E Q++ FQ K + + K+ + Q +
Sbjct: 984 CLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII-------LQKLA 1036
Query: 3486 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3545
N + + Q E +Q E D L+ F G++E G L + + QE +++
Sbjct: 1037 NVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK----LQVEQPSMQELSKLQD 1089
Query: 3546 RVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTDSLQSQIEDVRL 3604
+ +++ ++ G+ Q + L DL D L+ G + D + S E+++
Sbjct: 1090 MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQ 1149
Query: 3605 FLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE---ALNKQCGKLTERGKA 3658
L+K +E+ HM+ E + +++E + L Q + +R
Sbjct: 1150 LLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 1203
Query: 3659 RQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQ--K 3716
R +LE L E + + + + E E+ VG E ++ + ++Q K
Sbjct: 1204 RGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
Query: 3717 EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQE 3776
++ Q KL QV G+ L+ S LE + ++ W + K+++ + +L+
Sbjct: 1261 SSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKELHRLET 1316
Query: 3777 ALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQRLLDDR 3832
L H ++Q L+ WL ++ + S E ++V+ + + +D +
Sbjct: 1317 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 1376
Query: 3833 KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ 3892
+ + + G ++ + ++ D + +L ++S+WT+LL+ A Q++L + +
Sbjct: 1377 SSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 1435
Query: 3893 FHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
+ ++S+ E + E +G + I + + ++K + DI V
Sbjct: 1436 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDINCKQLTVDF 1493
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDRCCRKAALLDQALSNARL 4001
+ QS+ ++S + S+K D ++ + +Q K LL+ L +
Sbjct: 1494 ---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSE 1550
Query: 4002 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNG 4061
+ E+ V+ L E ++K + Q + D L + I ++K V++ +NG
Sbjct: 1551 Y-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG 1609
Query: 4062 QALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 4121
AL++ + ++ L + +A++ + L+ + + ++++ +
Sbjct: 1610 LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY 1669
Query: 4122 LREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELV 4177
L E L+ +G Q+ Q Q +L+K+ L ++ LL+
Sbjct: 1670 LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKEC 1725
Query: 4178 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWVAE 4233
E L + + N ++ + + I +++ A +Q Q+Y+ Q A
Sbjct: 1726 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 1785
Query: 4234 TKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTV 4293
T L A + D+ +Q + KDS+ L ++ +
Sbjct: 1786 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 1845
Query: 4294 LQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALI-AQLPS 4352
+Q SL Q A+ ++ L+ + F ++ E L WI E ++ Q PS
Sbjct: 1846 IQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 1905
Query: 4353 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENM 4412
+ D ++++ EE++ + P +D+L ++G +L LN +E ++ Q
Sbjct: 1906 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKE----IKRMQNLNRH 1960
Query: 4413 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 4472
++ I + +R L + Q F +K E +E L +L + I +
Sbjct: 1961 WSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTEQKLAVE--ISGNYQHLL 2015
Query: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
E ++ E+ Q ++ G+ L+ + Q D+D E KL + W+ +
Sbjct: 2016 EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGV 2071
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
RA++R +++ + W + ++ V L G+ I Q A
Sbjct: 2072 IRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ--QAR 2125
Query: 4593 TIKEETDGLHEELEFIRILGA---------DLIFACGETEKPEVRKSIDEMNNAWENLNK 4643
T+ +E +E F+R G+ L+ + + ++ + E+ W++ +
Sbjct: 2126 TLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM 2183
Query: 4644 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE-MKE 4702
+E+ +KL ++ ++ + + D L+ L T K +L++ + +
Sbjct: 2184 RLEEQKKKLAFLLK---DWEKCEKGIADSLEK--------------LRTFKKKLSQSLPD 2226
Query: 4703 FKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DETDRDIIREPLTELKHLWE 4749
E++ +Q+ ++L + +L L K T D I+ E + L+ WE
Sbjct: 2227 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE 2286
Query: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE-VELA 4808
L +++ R+ ++ L F +EL WLT E + +GD + E +E
Sbjct: 2287 ELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NGDILIEEMIEKL 2342
Query: 4809 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4868
K + +A + ++ + + G L ++S AS + +L +N W+ +L R
Sbjct: 2343 KKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 2401
Query: 4869 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGLPETAREQLDTHMELYSQ 4925
++L+ TL Q + L +ES+L+ KP E + +L+ EL
Sbjct: 2402 KKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRD 2459
Query: 4926 LKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKLE 4982
++ +L+ ++L D + ++ + Q+ L+++W + + ER+ K+E
Sbjct: 2460 IEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE 2519
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ 5042
E L +F + F +WL +E++ S +I ++++ + F +V+ Q
Sbjct: 2520 ETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ 2579
Query: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
+ +++ +L ++ +K ++ RW+ + +R R L + ++F
Sbjct: 2580 LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
Query: 5103 AWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL 5162
A ++ WL + + L + +E ++ D ++ ++ + K FQ+ + + I G L
Sbjct: 2640 ARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL 2697
Query: 5163 KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLY 5222
EK+ P D+ ++ L E+R V G+ VER HK L D ++
Sbjct: 2698 IEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHKKLIRLPLPDDEHDLSDRELE--- 2752
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK--RSGRELIENSRDDT 5280
ED DL D+ Q Q L+ RSGR+
Sbjct: 2753 ------LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD--------- 2797
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
+ + WD LS +S + +AL + E + + LR
Sbjct: 2798 --TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE---------EGQDDKDFYLRGAV 2846
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL---AVCHPDCITTIKHWIT 5397
L D AL+S I ++ K +++ R + E I+ P+ T+ K ++
Sbjct: 2847 GLSGDHSALESQI---RQLGKALDDSRFQIQQT----ENIIRSKTPTGPELDTSYKGYMK 2899
Query: 5398 IIR---------ARFEEVLTWAKQHQQRL---------ETALSELVANAELLEELLAWIQ 5439
++ R E L K+ ++ L ET + ++ ELL+ +
Sbjct: 2900 LLGECSSSIDSVKRLEHKL---KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKE 2956
Query: 5440 WAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAP 5499
+Q+ Q+ +++ + A + + + +E++ R + D T + K ++
Sbjct: 2957 LRMKQNLQKWQQ-FNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKEL--- 3012
Query: 5500 FIEKSRSGGRKSLSQPTPPPMPILSQSEAK-----NPRINQLSARWQQVWLLALERQRKL 5554
+ RK++ P +Q+++K R++Q++ RW +V L E + L
Sbjct: 3013 ---QKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLL 3069
Query: 5555 NDALDRLEELKEFAN 5569
DAL + + E ++
Sbjct: 3070 QDALMQCQGFHEMSH 3084
Score = 258 bits (659), Expect = 1e-67
Identities = 641/3361 (19%), Positives = 1348/3361 (40%), Gaps = 376/3361 (11%)
Query: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWN------SRLLHFQNAVE 1914
EL+ Q + Q ++ L K + K + Q+++ + + S L + +E
Sbjct: 2 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
Query: 1915 -----IEKTKVLNQHTQLEGRLQDLRA-WVGNKNLILNSKGSNSEIDVDSLNLCLQQYED 1968
IEK KVL T LR ++ ++ L+ SK +SE++ + L
Sbjct: 62 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
Query: 1969 LKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQV 2028
+ M+++ A+L +++ I Q+L + M + EL++ Q LEQ A +
Sbjct: 122 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA-KDMKKFEAELKK-LQAALEQAQATL 179
Query: 2029 DALQ-GHLQQMEQEALVKTLQKQQNTCHQQLE--DLC-SWVGQAERALAG----HQGRTT 2080
+ + G L EQ + + L + + +++ LC S + E +A H
Sbjct: 180 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRL 239
Query: 2081 QQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL-TALREKLH 2139
Q++ S LQ ++ + + +K ++ +E ++ + + T+ ++L
Sbjct: 240 QEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQ 299
Query: 2140 QAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA---------KELAENKKKIDAL 2190
++E L ++ + Q+++ ++ S + T K+K A + LAE + +D
Sbjct: 300 AQISRHEELAQKIKGYQEQIA-SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGE 358
Query: 2191 LDWVTSVGSS-----GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCE 2245
L S S G+ T L + + SG + + + D
Sbjct: 359 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANT-DASVN 417
Query: 2246 MMKARHQELLSQQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 2300
A +Q L +++ A T ++Q F + P + KLG+L+ + T
Sbjct: 418 QDIAYYQALSAERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWET 470
Query: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360
+ + + + QK+ + + +E E +L + G SPE S +
Sbjct: 471 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEH 527
Query: 2361 GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHS 2420
+ ++++ + ++ + S + L E+ + E + + L ER + +
Sbjct: 528 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRM 583
Query: 2421 KCTR----LGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPG 2470
K + L LN L + Q ++ AD L +W+ + +A ++ LS +P
Sbjct: 584 KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPM 641
Query: 2471 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2530
++ QL + + E+ + V + +L V + + +EG+ H ++ + + +
Sbjct: 642 DMEAQLMDCQNMLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRR 695
Query: 2531 LSYSLAE-RSSLLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQ 2584
L SL E + +L K + + QE ES QS G E + + + Q
Sbjct: 696 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---Q 752
Query: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQ 2644
+L +L+Q++A QKS L R + +R E +AA G E Q +
Sbjct: 753 SSLQQQKELEQELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 809
Query: 2645 QEKESSLKKLLPQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPD 2686
EK S+ ++ + E + + S K LQ +E + L G+ P
Sbjct: 810 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 869
Query: 2687 QDITHFFQQIQELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2738
QD + + LN E+ +++++ + L +S+ LD + + V
Sbjct: 870 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 929
Query: 2739 -LRKDFTELQKTVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------ 2783
L + TE +E KD E++D+ + L + +++T G
Sbjct: 930 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 989
Query: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAP 2838
S+ + + +++++++ + + +D T + + + E + E
Sbjct: 990 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEA 1049
Query: 2839 DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898
Q + G G G + +Q ++S + Y++L ++ R+ L
Sbjct: 1050 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQN 1108
Query: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958
L + + + LE+ +E + + +K E ++ + +K + LE +
Sbjct: 1109 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH--- 1164
Query: 2959 IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQ 3018
+ E L ++++ +E + ++ + ++ +RA + V + LE + SHL
Sbjct: 1165 -MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---D 1219
Query: 3019 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 3078
+ +L L E + +G + + + L + Q + + + Q+ + +
Sbjct: 1220 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 1279
Query: 3079 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 3138
+L +S+S S ++ +L + + W+ T+K++ +++ + T+YQ DL
Sbjct: 1280 LL-----ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 1334
Query: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
+++ RL + Q V Q+LE + + + EV +AQ+ + G Q
Sbjct: 1335 LQSAKDRLEFWTQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQL 1390
Query: 3199 LKDELKKRLETVAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWL 3249
L+ K+++T L L ++ D + + A Q Q E+ +W+
Sbjct: 1391 LR---LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 1447
Query: 3250 DDKQSQQAK---NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVP 3305
++ K N S + + LQ+ + F+ +N + + + +S+L +S
Sbjct: 1448 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQ 1504
Query: 3306 PGEEKRT----LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
E KR+ QL + W+ L ++ L+ ++ +Y+ +V+ L W E
Sbjct: 1505 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 1564
Query: 3362 CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIR 3421
+ ++ + D ++++L + + + ++ + +E + LI + + D I
Sbjct: 1565 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI- 1623
Query: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 3481
+ + EL +L+ M +L+ +S + + + H++ FD + S
Sbjct: 1624 ---------VMSTLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINS 1668
Query: 3482 QACSNK-NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVA 3536
+ +L + R L+A++ QVD L+N L + GS +QLL +
Sbjct: 1669 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 1728
Query: 3537 QQEFL-----EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRD 3591
E L EV R N+ ++E E + Q + +++ + D +
Sbjct: 1729 VTETLTNTLKEVNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQ 1774
Query: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEAL 3645
S Q ED L K K DI E +C +L+ GT+ D L EL
Sbjct: 1775 CASTVQQQEDRTNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 1833
Query: 3646 NKQCGKLTERGKARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVV 3697
KQ + + +QL L+ L +E K + G+ D T A+ EAL+ W+V
Sbjct: 1834 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 1893
Query: 3698 GTEVEIINQQ----LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE- 3750
E EI+ Q +D Q E+++ L+ ++ + + + L + G + E
Sbjct: 1894 EAE-EILQGQDPSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 1951
Query: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810
M+ +N W+ ++ + +R ++LQ LL F + E + +L TE+ +A + S
Sbjct: 1952 KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SG 2009
Query: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT 3870
Y+ + Q + +L Q + R+ + + +G R+ + ++ DR++ +L L ++W
Sbjct: 2010 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 2069
Query: 3871 ELLSKAAARQKQLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQ 3927
++ +A R+ ++ + +++ E AE + +L S S P+ Q A+
Sbjct: 2070 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 2129
Query: 3928 IIRHKALEEDIENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC 3986
++ K E+ V+ G Q L S S AE +LQA +EIQ++
Sbjct: 2130 EVQFK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWK 2179
Query: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046
+ L++ +D + +A+ +KL + FK+ + H L+ E
Sbjct: 2180 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAE 2234
Query: 4047 IVNRKKNVDQAIKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSS 4095
+ R K ++ A+ + +LLK T + +++ ++ E+++ ++ ++ ++ S
Sbjct: 2235 QM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
Query: 4096 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155
+ + + F +EL WL ++E +++ +G E I + ++ +E
Sbjct: 2294 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAI 2352
Query: 4156 VMEHRLVLDTVNE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
E+++ L + E +++A E +A E ++ + N++++ + D I RV ++ +
Sbjct: 2353 AQENKIQLQQMGERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETL 2408
Query: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDS 4271
QQ ++ + W+A + +L PI + ++ +L Q+ DI +H
Sbjct: 2409 VAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 2466
Query: 4272 MDELFSHRSEIFGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 4327
+ + + + C + + +Q+ T +L +++ I ++ ER ++E L
Sbjct: 2467 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 2526
Query: 4328 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387
+F + Y W++ + A S + + +++ ++ + + E ++ + K
Sbjct: 2527 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 2586
Query: 4388 GPQLKELNPEEG-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
+L N + +MV E Q+ +N+ ++ +R+ L + Q + D
Sbjct: 2587 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARD 2642
Query: 4443 KIEPMLETLENLSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKR 4497
I L ++ L ++ EC I K+ E+ E +
Sbjct: 2643 SILVWLTEMD----------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 2692
Query: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------E 4538
+GE+LI +S+ D A I+++LD++ + +++ R E +
Sbjct: 2693 QGEQLIEKSEPLD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 2748
Query: 4539 REIKFLDVLELAEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4597
RE++ D L++ W+D +A L + + + ++ L P + + ++I E
Sbjct: 2749 RELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE 2808
Query: 4598 TD---GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654
D L +LE G+ +K + ++ L ++ + L+D
Sbjct: 2809 WDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDD 2868
Query: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQQI 4712
+ Q ++ +++ K T P + T L E V+ + ++
Sbjct: 2869 SRFQIQQTENIIRS----------KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 2918
Query: 4713 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
+ E+ + G + L +T I R WE L + ++ +++ L QF
Sbjct: 2919 KEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQQF 2969
Query: 4773 QHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830
L + +WL TEE L+ + +S D + IE+++ K L+ V +A + ++N
Sbjct: 2970 NSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLC 3029
Query: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890
E ++ + ++ L+ RL MN W+ V EE LQ L Q QGFH LL
Sbjct: 3030 SPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLL 3088
Query: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS 4950
L ++ + + P E L H + Q+K ++LL+ + +D S
Sbjct: 3089 MLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQDMS 3140
Query: 4951 GSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLTLA 5005
+ LE +K HV+ ++++ + S+ + L + +S Q+ +W +
Sbjct: 3141 CQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSAD 3200
Query: 5006 E 5006
E
Sbjct: 3201 E 3201
Score = 254 bits (650), Expect = 1e-66
Identities = 646/3387 (19%), Positives = 1334/3387 (39%), Gaps = 418/3387 (12%)
Query: 2233 VNQAPEKLDKQCEMMKA--RHQELLSQQQNFILATQSAQAFLDQHG-HNLTPEEQQMLQQ 2289
+NQA L++ EM++ + E + +A SA +Q+ H EE + +
Sbjct: 46 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 105
Query: 2290 KLGELKE--QYSTSLAQSEAELKQVQTLQDE--------------LQKFLQDHKEFESWL 2333
+L + E QY TS+ +E +QV L E LQ +D K+FE+ L
Sbjct: 106 ELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAEL 165
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
++ + LE +SPE LK Q S + ++S L+ Q V +++ +
Sbjct: 166 KKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV---QAVQLCQSALRI 222
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
++ L L+ E H+ + + + QY Q++ LQ ++
Sbjct: 223 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI-MQAAVVQYEQYEQEMKHLQQLIEGA 281
Query: 2454 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD 2513
+E S+ LQ Q++ ++L +++ +Q + L + ++ ++ + A
Sbjct: 282 HREIED--KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCK-MLTMKAKHATM 338
Query: 2514 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES-LLQSIGEVEQNLE- 2571
V E + + + L L S + + +L S + + GE N E
Sbjct: 339 LLTVTEV-EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI 397
Query: 2572 --------GKQVSSLSSGVIQE-----ALATNMKLKQDIARQKSSLEATREMVTRFMETA 2618
V++ + V Q+ AL+ +L+ D A+ S A++E +E
Sbjct: 398 SSPPACRSPSPVANTDASVNQDIAYYQALSAE-RLQTDAAKIHPSTSASQEFYEPGLEP- 455
Query: 2619 DSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQFMEN 2674
S TA KL ++ + +E L EK+ +L + L + + ++ +S K++
Sbjct: 456 -SATA-----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELK 509
Query: 2675 KSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL-EHLVTELSSCGFALDLCQHQ 2733
S G P+ + + E+ + ++ E +L E LV+E A L
Sbjct: 510 LSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQS 569
Query: 2734 ------DRVQNLRKDFTELQKTVKEREKDASSCQEQ---LDEFRKLVRTFQKWLKETEGS 2784
+R+ +R + ++ ++E+ D Q Q L +R WL T+ +
Sbjct: 570 TLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 629
Query: 2785 I-----PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD 2839
+ PP E ++E Q+ +++L + K + E++ ENL++E
Sbjct: 630 LDTALSPPKEPM----DMEAQLMDCQNMLVEIEQKVVALSELSVHN---ENLLLE----- 677
Query: 2840 SQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAIL 2899
GK HT + ++ + + +L LH++Q ++Q
Sbjct: 678 --GKA-----------------HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTA 718
Query: 2900 NRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2959
+ KEE + A SP E + AQA + +Q +
Sbjct: 719 -----------------QEKEESDVDLTATQSPGVQEWL-AQARTTWT-----QQRQSSL 755
Query: 2960 QKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQA 3019
Q+ KE QE K + + SR E E H A +
Sbjct: 756 QQQKEL----------EQELAEQKSLLRSVASRGE-------------EILIQHSAAETS 792
Query: 3020 AESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEF---EARRQQHEQL---- 3072
++ +P ++ +EL M + D + + +F K+ Q+ EQ+
Sbjct: 793 GDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSR 852
Query: 3073 -NEAAQGILTGPGDV-SLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 3130
N G+ GDV + S V L +NQ + E+ SSQ A +S ++
Sbjct: 853 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV-------SSQSGGAKRQSIHLEQ 905
Query: 3131 LLQD----LSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTL 3186
L D S + V +RL V +A+ PE + L + D++++ E+ + + L
Sbjct: 906 KLYDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMSEEMDKNKNL 963
Query: 3187 CDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELR 3246
+ G+ +D ++ L + L L+ + R ++++ L FQ L
Sbjct: 964 FSQAFPENGDN--RDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLF 1021
Query: 3247 TWLDDKQS---QQAKNC---PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 3300
T L D + Q+ N P++ ++E +Q +EF + + + G+ L
Sbjct: 1022 TSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE-------LKRRGDKL 1074
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
+ P +E L +L++ ++EL R+S L + +Y+ ++DL +E
Sbjct: 1075 QVEQPSMQE-------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLE 1127
Query: 3361 DCKAKMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 3418
+ KM+ + + +++ L + K +E L E L +I+ + E
Sbjct: 1128 TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRK---IISFAVQKET 1184
Query: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDA 3478
E + AV + + LE + E++ ++++ + QLE+ ++
Sbjct: 1185 QFHTE---LMAQASAVLKRAHKRGVELEYIL-------ETWSHLDEDQQELSRQLEVVES 1234
Query: 3479 -LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGS------DASQLLH 3531
+ S +N ++L + + Q L+ L + L + DG S L
Sbjct: 1235 SIPSVGLVEENEDRLIDRITLYQHLKSS---LNEYQPKLYQVLDDGKRLLISISCSDLES 1291
Query: 3532 QAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRD 3591
Q + +L +++ +E L+ ++ ++ L D L+ +
Sbjct: 1292 QLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT---QQ 1348
Query: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL------DLLGLKRELEAL 3645
+ ++ ++E VR LN +++A + +L L D L+ EL +
Sbjct: 1349 SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRI 1408
Query: 3646 NKQCGKLTERGKARQEQL-ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV--E 3702
+ Q L A QE+L +L + ++ + + ++ + + + + + +
Sbjct: 1409 DSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYK 1468
Query: 3703 IINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC-----DVQGLEHDMEEIN 3757
I++ L +K F+ + + K V+ + Q ++Q + +D D + +N
Sbjct: 1469 AIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMN 1524
Query: 3758 ARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKA 3817
W L V ++I L+ L ++++ ++ L +W +T+E Q+ + V+
Sbjct: 1525 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQN 1583
Query: 3818 QIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAA 3877
+++ + L+ L+ ++ V+ ++ G + Q+ + + L L W L
Sbjct: 1584 ALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVG 1643
Query: 3878 ARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEED 3937
+ L+ +L + I+ +L L+ + +Q Q+ + L++D
Sbjct: 1644 QLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDD 1703
Query: 3938 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3997
+E + + I L P L+ + + R++ + + + L
Sbjct: 1704 LEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQ 1763
Query: 3998 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 4057
+ + + + + + + ED+ + + +D+ + A + +++ V +
Sbjct: 1764 LWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDS 1823
Query: 4058 I----KNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 4113
+ + G+ L +Q IQ + + K +L+ F
Sbjct: 1824 LFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAK 1883
Query: 4114 TYEELTGWLREVEEELATSGGQSPT-GEQIPQFQQRQKELKKEVMEHRLV---LDTVNEV 4169
+ E L W+ E EE L GQ P+ + Q+R +ELK ++++ + LD +NE+
Sbjct: 1884 SLEALEAWIVEAEEILQ---GQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940
Query: 4170 SRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA 4229
L P +E K + + N + L+S +R ++ + + + Q + + + +
Sbjct: 1941 GYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 1994
Query: 4230 WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEE 4289
++ +T++KL + + + L+ Q+A H+ E+FS + + +
Sbjct: 1995 FLVQTEQKLA----VEISGNYQHL-LEQQRA-------HELFQAEMFSRQQILHSIIIDG 2042
Query: 4290 QKTVLQEKTESLIQQYEAISLLNSERYARLERAQ----VLVNQF--WETY----EELSPW 4339
Q+ + Q + + + ++LL+++ + RAQ ++ +Q W+ Y E+L W
Sbjct: 2043 QRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKW 2102
Query: 4340 IEETRAL-IAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398
+ E L ++ L S I +Q R +E++ + + ++ G QL L+ +
Sbjct: 2103 LVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL-LSADS 2161
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP-MLETLENLSS- 4456
G E +AE A+I+E+ + ++ L+E + + + +K E + ++LE L +
Sbjct: 2162 GA---EAALQAE--LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTF 2216
Query: 4457 RLRMPPLIP-------AEVDKIREC----------------ISDNKSATV---ELEKLQP 4490
+ ++ +P AE + +E + D SA + ++ L
Sbjct: 2217 KKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNE 2276
Query: 4491 SFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELA 4550
E L+R+ EEL + L ++I ++L++ F E K EL
Sbjct: 2277 RVELLQRQWEELCHQLS-----LRRQQIGERLNEWAVFSEKNK--------------ELC 2317
Query: 4551 EKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF-IR 4609
E W + + + + DI +I++ +E + +E + +E + ++
Sbjct: 2318 E--W--LTQMESKVSQNGDI------------LIEEMIEKLKKDYQEEIAIAQENKIQLQ 2361
Query: 4610 ILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAM 4669
+G L A E++ E+ + ++N+ W++L R++KL++ + A Q + ++
Sbjct: 2362 QMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSL 2421
Query: 4670 FDWLDNTVIKLCTMPPVGTDLNT--VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKK 4727
WL + +L P V N+ ++ +LNE +E + ++ + + + + E++L
Sbjct: 2422 RTWLAHIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHD 2480
Query: 4728 ----ATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWL 4783
ATD + D I++ L W N+ R+ K+E +F WL
Sbjct: 2481 CDACATD-AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 2539
Query: 4784 THTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDA 4843
+E V + EL K + V +E +NK L + D A
Sbjct: 2540 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 2599
Query: 4844 SSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASK 4903
SL+ + NQ W+++ ++ ++L+ + Q + F + + L+ LT M+ QL+ +
Sbjct: 2600 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 2659
Query: 4904 PTGGLPETAR-EQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVAL 4962
A+ +QL + ++ Q++ +G L+ + + + E+ +
Sbjct: 2660 HFSECDVQAKIKQLKAFQQ---EISLNHNKIEQIIAQGE-QLIEKSEPLDAAIIEEELDE 2715
Query: 4963 LEQKWHVVSSKMEERKSKL--------EEALN---LATEFQNSLQEFINWLTLAEQSLNI 5011
L + V ++E KL E L+ L E +L + ++W + SL +
Sbjct: 2716 LRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSD-LHWHDRSADSL-L 2773
Query: 5012 ASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVS 5071
+ PS L+ L+Q + + A D I L D L ++L
Sbjct: 2774 SPQPSSNLSLSLAQPLRSERSGRDTPASVDSIP-----------LEWDHDYDLSRDL--- 2819
Query: 5072 VQSRWEKVVQRSIERGRSLDDARKRA----KQFHEAWKKLIDWLEDAESHLDSELEISND 5127
+S + + E G+ D R H A + I L A DS +I
Sbjct: 2820 -ESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALD--DSRFQIQQT 2876
Query: 5128 PDKIKLQL-------SKHKEFQKTLGGKQPVYDTTIRTGRALKEKT-LLPE--DSQKLDN 5177
+ I+ + + +K + K LG D+ R LKE+ LP + +
Sbjct: 2877 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 2936
Query: 5178 FLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD 5237
V D+W+ + +++ ++ ++++ L QF L ++ WL E +L + Q +
Sbjct: 2937 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 2996
Query: 5238 LDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWD 5295
D+ + K+ QK + R + + E + ++ ++ +L +++ RWD
Sbjct: 2997 TDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD 3056
Query: 5296 TVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-LQSLID 5354
VC L + L+ AL Q + F + H LL L ++ R +P D+ + L D
Sbjct: 3057 RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQD 3114
Query: 5355 THKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKHWITIIRARFEEVLTWA 5410
HK+ M+ ++ E ++ V S M ++++ DC+ K + +I R + +L
Sbjct: 3115 HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLKEV 3173
Query: 5411 KQHQQRLETALSELVANAELLEELLAW 5437
+H + LE L V++++ ++L +W
Sbjct: 3174 SRHIKELEKLLD--VSSSQ--QDLSSW 3196
Score = 209 bits (533), Expect = 5e-53
Identities = 572/3039 (18%), Positives = 1174/3039 (38%), Gaps = 425/3039 (13%)
Query: 1566 PSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLK 1625
PS ++ TD S Q+ Y + + + +I S ++ Y E +P+ K
Sbjct: 406 PSPVANTDAS----VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFY-EPGLEPSATAK 460
Query: 1626 LEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANP 1685
L ++ S K V S+++ ++ + K +L+S E K E P
Sbjct: 461 LGDLQRSWETLKNV----ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 516
Query: 1686 N------VAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLET 1739
+A +A E ++ Q L S L E+L + + Q L
Sbjct: 517 GRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQ---------LAL 567
Query: 1740 SEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFT 1799
TV S ++ + + + +L E ++Q E R Q
Sbjct: 568 QSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL----------------EEQRQEQ-ALQ 610
Query: 1800 RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVS 1859
R C E DE L S+L L + T P E E Q + CQ ++E E K +
Sbjct: 611 RYRC-EADE-LDSWL-LSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK---VVAL 664
Query: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQN-AVEIEKT 1918
EL N+ ++ + + + L + L+ SL + + + L+ Q A E E++
Sbjct: 665 SELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEES 724
Query: 1919 KVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA 1978
V TQ G ++ W+ + +S LQQ ++L+Q +AE+K+
Sbjct: 725 DVDLTATQSPG----VQEWLAQARTTWTQQRQSS----------LQQQKELEQELAEQKS 770
Query: 1979 QLDALAFDIQFFISEH-AQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQ 2037
L ++A + + +H A + S + L EL E+++A+ D ++ +
Sbjct: 771 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG----EKSSAE-DQMRMKWES 825
Query: 2038 MEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAG---HQGRTTQQDLSALQKNQSDL 2094
+ QE K + QN Q+ E + + R L+G ++G QD SA+ L
Sbjct: 826 LHQEFSTKQ-KLLQNVLEQEQEQVL--YSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGL 882
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRV 2154
+++ +++ A R+ +H ++ Y+ + T
Sbjct: 883 NQAFEEVSSQSGG-------------------------AKRQSIHLEQKLYDGVSA-TST 916
Query: 2155 AQKELEEAV---TSALQQETE-----KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206
++EE + T+ L +ETE + AK++ E +++D + + G
Sbjct: 917 WLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD--- 973
Query: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQ 2266
N +E G L G L D VNQ +C MK R Q++L+ Q + +
Sbjct: 974 NRDVIEDTLGCLL--GRLSLLDSV--VNQ-------RCHQMKERLQQILNFQNDLKVLFT 1022
Query: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTSLAQSEAELKQVQTLQDELQ--- 2320
S L + + + + + +Q + E E Q L + +A + +++ D+LQ
Sbjct: 1023 S----LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ 1078
Query: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH-----KGDLR 2375
+Q+ + + + + + G + TL S +R D++ GD +
Sbjct: 1079 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 1138
Query: 2376 FVTISG---QKVLDMENSFKEGKEPSEI--GNLVKDKLKDATERYTALHS---------- 2420
+ S Q++LD + +G E I L + + A ++ T H+
Sbjct: 1139 IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVL 1198
Query: 2421 -KCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATT 2479
+ + G L +L + L ++ E+++ + V + L +++
Sbjct: 1199 KRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV--GLVEENEDRLIDRITLY 1256
Query: 2480 KQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERS 2539
+ L+ L E+Q + ++ + ++ I + + + + LS+ +S L
Sbjct: 1257 QHLKSSLNEYQPKLYQVLDDGKRLL-ISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 1315
Query: 2540 SLLQK----------AIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALAT 2589
++L+ I QS ++ LE Q V Q LE ++++ L
Sbjct: 1316 TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE----------MVRDHLNA 1365
Query: 2590 NMKLKQDIARQ---KSSLEATREMVTRFMETADSTTAAVLQG----------KLAEVSQR 2636
++ +++ Q KSS+ +T + R + +T + L + V ++
Sbjct: 1366 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 1425
Query: 2637 FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI 2696
QL + + ++ +++ + E++ K + ++N A I + Q+
Sbjct: 1426 LHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--------IHEYLQKY 1477
Query: 2697 QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL---RKDFTELQKTVKER 2753
+ +++ +Q +D + V ++SS D + L K + LQ V E+
Sbjct: 1478 KGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK 1537
Query: 2754 EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWAS 2813
+ E E+ V+ + W + E + ++ ++ + L D +
Sbjct: 1538 IQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKA 1597
Query: 2814 KGTLVEEINCKGTSL--------ENLIMEITAPDSQ---------GKTGSILPSVGSSVG 2856
K VE+I G +L +++M Q G+ +L SV
Sbjct: 1598 KEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS 1657
Query: 2857 S-------VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909
S +N Y L E + +S ++ L G L Q + + N +++ K+
Sbjct: 1658 SHKVAFDKINSY-----LMEARYSLS----RFRLLTGSLEAVQVQVDNLQNLQDDLEKQE 1708
Query: 2910 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2969
S+ ++ ++LK + T T T+K E N + LE+ + ++Q K L
Sbjct: 1709 RSLQKFGSITNQLLKECHPPVTETLTNTLK---EVNMRWNNLLEEIAEQLQSSKALL--- 1762
Query: 2970 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 3029
Q + +K ++ S ++ + R +L ++A++ A+ ++ W+
Sbjct: 1763 -------QLWQRYKDYSKQCASTVQQQED----RTNELLKAATNK---DIADDEVATWIQ 1808
Query: 3030 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
+ ++ LG + K + F+ + E +QQ + + +
Sbjct: 1809 DCNDLLKGLGTV----------KDSLFFLHELGEQLKQQVD----------------ASA 1842
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
S +Q + S++Q L L + + + ++ + + L+ L + + L Q
Sbjct: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
Query: 3150 --------SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 3201
S I + E +K Q+ + S + DL++L+ EL + L D
Sbjct: 1903 DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN-----------ELGYRLP---LND 1948
Query: 3202 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK-QSQQAKNC 3260
+ KR++ + + +R ++LQ+ L Q F ++ TW++ Q++Q
Sbjct: 1949 KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAV 2005
Query: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
IS + L Q + +E FQ + I+ +G+ LL +++ +L L
Sbjct: 2006 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLL-EQGQVDDRDEFNLKLTLL 2064
Query: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW-IEDCKAKMSELRVTLDPVQLE 3379
N W+ + ++ R+ + +++ Q+Y+ E L W +E MS L P+Q
Sbjct: 2065 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 2124
Query: 3380 SSLLRSKAMLNEVEKRR--SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEE 3437
+L +V R+ S + + + +L+++ E ++ E A I E+
Sbjct: 2125 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQ-------EK 2177
Query: 3438 LQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQE 3497
++ + LEE ++L + ++ EK + + +L F SQ+ + + E+L A+Q
Sbjct: 2178 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH-EELHAEQM 2236
Query: 3498 VLQALEPQV-DYLRNFTQ-GLVEDAPDG----SDASQLLHQAEVAQQEFLEVKQRVNSGC 3551
+ LE V + + TQ L++D D S L + E+ Q+++ E+ +++
Sbjct: 2237 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRR 2296
Query: 3552 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3611
+ +L F + +E+ L ++ ++ G I L I
Sbjct: 2297 QQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI---------------LIEEMIEK 2341
Query: 3612 LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVE 3671
LK D + A + +E K +L+ + ++ K + KA ++E LG+V
Sbjct: 2342 LKKDYQEEIA-----IAQEN-------KIQLQQMGERLAKASHESKA--SEIEYKLGKVN 2387
Query: 3672 DFYRKL--------KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQ 3723
D ++ L K L + A ++ + + T + I +LA ++ + +Q
Sbjct: 2388 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQ 2447
Query: 3724 MKLQQVNGLGQGLIQ-SAG------------KDCDVQGLEHDMEEI-------NARWNTL 3763
KL + L + + + S G DCD + + + I + RW +
Sbjct: 2448 RKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNI 2507
Query: 3764 NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQK 3823
+R +++E KF D WL +E A Y V K ++++ +
Sbjct: 2508 CAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE 2567
Query: 3824 LLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3883
QR + + ++++ + R+A+ + + RW L + + ++L
Sbjct: 2568 AFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRL 2627
Query: 3884 EDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHAT 3943
+ + ++F + I +L+ + +L N E +Q +I + KA +++I +
Sbjct: 2628 KHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE--CDVQAKIKQLKAFQQEISLNHN 2685
Query: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-F 4002
+ Q + G+ L + P + ++ E++D L+ E+ R R L RL
Sbjct: 2686 KIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL------IRLPL 2739
Query: 4003 GEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062
+DE ++ + E+ED S + D H + AD L + N ++ Q +++ +
Sbjct: 2740 PDDEHDLSDRELELED---SAALSDLHW---HDRSADSLLSPQPSSNLSLSLAQPLRSER 2793
Query: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF--------QST 4114
+ + T V I + D D+ S+AL + ++ Q F
Sbjct: 2794 S--GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGD 2851
Query: 4115 YEELTGWLREVEEELATSGGQSPTGEQI--------PQFQQRQKELKKEVMEHRLVLDTV 4166
+ L +R++ + L S Q E I P+ K K + E +D+V
Sbjct: 2852 HSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV 2911
Query: 4167 NEVSRALLE----LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 4222
+ L E L + + + ++++L+ + + +Q+ QQ+
Sbjct: 2912 KRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNS 2971
Query: 4223 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID-IIRHKDSMDELFSHRSE 4281
++ AW+ +T+ +L L + L D T +LQ++K + + H+ ++ + S
Sbjct: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
Query: 4282 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 4341
F ++ LQ++ + +++ + L E L+ A + F E L +E
Sbjct: 3032 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 3091
Query: 4342 ---ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398
+ I + S +D E L+ +++ Q++ + E + + L + QL +N E
Sbjct: 3092 NIDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL-VNAEG 3149
Query: 4399 GEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQST 4435
+ +E EK N + +EV + L++ + S+
Sbjct: 3150 TDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSS 3188
Score = 187 bits (475), Expect = 3e-46
Identities = 548/3186 (17%), Positives = 1207/3186 (37%), Gaps = 458/3186 (14%)
Query: 1837 LQDLLCQAKVLERELKDLTTLVS---QELECVNQIIISQPQEVPAQLLK--ALEKDAKNL 1891
+Q + Q + E+E+K L L+ +E+E + S QE+ AQ+ + L + K
Sbjct: 257 MQAAVVQYEQYEQEMKHLQQLIEGAHREIED-KPVATSNIQELQAQISRHEELAQKIKGY 315
Query: 1892 QKSLSSVSDTWNSRLLHFQNA---VEIEKTKVLNQHTQ-LEGRLQD--------LRAWVG 1939
Q+ ++S++ + ++A + + + + L + T+ L+G L + G
Sbjct: 316 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 375
Query: 1940 NKNLILN-------SKGSNSEID----------VDSLNLCLQQYEDLKQPMAERKAQLDA 1982
+ +L+ +G+NSEI V + + + Q Q ++ + Q DA
Sbjct: 376 RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDA 435
Query: 1983 LAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA 2042
S+ + P L +LQRS++ + + + Q
Sbjct: 436 AKIHPSTSASQEFYE--PGLEPSATAKLGDLQRSWETLKNVISEK------------QRT 481
Query: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAG--HQGRTTQQDLSALQKNQSDLKDLQDD 2100
L + L++QQ L+ + + + E L+ GR+ + ++ Q ++ LQD+
Sbjct: 482 LYEALERQQKY-QDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540
Query: 2101 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 2160
I +S A E + E+ + P E AL+ L E+ ++ + ++ LE
Sbjct: 541 INELQSSLA------EELVSES-CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLE 593
Query: 2161 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 2220
E + L+++ ++ + L + + D L W+ S
Sbjct: 594 EKLNDQLEEQRQE----QALQRYRCEADELDSWLLST----------------------- 626
Query: 2221 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNL- 2279
K LDT ++ E +D + ++M ++ L+ +Q + ++ L H NL
Sbjct: 627 KATLDTA-----LSPPKEPMDMEAQLMDCQNM-LVEIEQKVVALSE-----LSVHNENLL 675
Query: 2280 ------TPEEQQMLQQKLGELKEQY-STSLAQSEAELKQVQTLQDELQKFLQ----DHKE 2328
T +E + L KL LK A + +L T Q++ + +
Sbjct: 676 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPG 735
Query: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
+ WL ++ + S L++Q +++ K LR V G+++L
Sbjct: 736 VQEWLAQARTTWTQQRQ---------SSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 786
Query: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
++ + + E +++ +L E+ +A + M HQ ++
Sbjct: 787 SAAETSGDAGEKPDVLSQELGMEGEKSSA--------EDQMRMKWESLHQEFSTK----- 833
Query: 2449 WMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG 2508
+KLL + + E + QV + ++ + +G
Sbjct: 834 ---------QKLLQNVL-------------------EQEQEQVLYSRPNRLLSGVPLYKG 865
Query: 2509 E-PAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567
+ P D V D + F+ +S ++ +++I Q + + + + + +VE
Sbjct: 866 DVPTQDKSAVTSLLDGLNQAFEEVS---SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVE 922
Query: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTR-FMETADST----- 2621
+ L ++L + L L +DI ++ + + ++ F E D+
Sbjct: 923 ERLF--VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIED 980
Query: 2622 TAAVLQGKLAEVSQRFEQLCLQQQEK-------ESSLKKLLPQAEMFEH--LSGKLQQFM 2672
T L G+L+ + Q C Q +E+ ++ LK L ++ L F
Sbjct: 981 TLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFE 1040
Query: 2673 ENKSRMLASGNQPDQDITHFFQQIQELN-----LEMED-QQENLDTLEHLVTEL------ 2720
+ + + + Q + + F I EL L++E + L L+ + EL
Sbjct: 1041 QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGS 1100
Query: 2721 --SSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK-DASSCQEQLDEFRKLVRTFQKW 2777
S L L +R +D +L +T +E+ D +E ++L+ +++
Sbjct: 1101 RRSGLNQNLTLKSQYERAL---QDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY 1157
Query: 2778 LKETEGSIPPTET---SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME 2834
+ E + TET + + ++K+ + L+ A +++ + +G LE ++
Sbjct: 1158 FQGLESHMILTETLFRKIISFAVQKETQFHTELM---AQASAVLKRAHKRGVELEYILET 1214
Query: 2835 ITAPDSQGK--------TGSILPSVG-------SSVGSVNGY-HTCKDLTEIQCDM---- 2874
+ D + S +PSVG + + Y H L E Q +
Sbjct: 1215 WSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVL 1274
Query: 2875 ------------SDVNLKYEKLGGVLHERQESLQAILNRMEEVHK-------EANSVLQW 2915
SD+ + +LG + L+R+E + K E+ ++ W
Sbjct: 1275 DDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 1334
Query: 2916 LESKEEVLK--SMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTY 2973
L+S ++ L+ + +++ P + E V+ + F E++ S V LL
Sbjct: 1335 LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL- 1393
Query: 2974 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM---- 3029
+ + ++S+W A Q +L + + A S++ W+
Sbjct: 1394 -KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMEN 1452
Query: 3030 ----EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGD 3085
+++ + +G +I + + ++ K+ L ++Q + + D
Sbjct: 1453 VIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD 1512
Query: 3086 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQR 3145
+ ++L ++N+ W L + + ++ + ++Y+ +Q L +R
Sbjct: 1513 ----KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 1568
Query: 3146 LSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY-LKDELK 3204
L Q I Q +V+ L++ ++ ++ + EV++ + + L+++ ++ + +
Sbjct: 1569 LKQQHRIGDQA-SVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSIVM 1625
Query: 3205 KRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISA 3264
L + L+ + L++ L + FD++ ++L + + ++ ++
Sbjct: 1626 STLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTG 1685
Query: 3265 KLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV-PPGEEKRTLQNQLVELKNH 3323
LE +Q Q+ + Q L + S + + LL PP E TL N L E+
Sbjct: 1686 SLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE--TLTNTLKEVNMR 1743
Query: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
W L ++ A++ K +Q Q+Y+ + + ++ + + +EL +
Sbjct: 1744 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADD-- 1801
Query: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADED-----------GIRDEKAGINQNMD 3432
+ ++ LL+ L + D L E E I+ ++ ++Q++
Sbjct: 1802 ---EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLC 1858
Query: 3433 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN--KNLE 3490
A+ + L + SL+ F +S + +E + A+ L+ D S S + +E
Sbjct: 1859 ALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERME 1918
Query: 3491 KLRAQQEVLQALEPQVDYL-----------------RNFTQGLVEDAPDGSDASQLLHQA 3533
+L+ Q ++ P +D L +N + + ++ L
Sbjct: 1919 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSF 1978
Query: 3534 EVAQQEFLEVKQRVNSGCVMMENKL--EGIGQFHC-----RVREMFSQLADLDDELDGMG 3586
+ Q FLE + V E KL E G + R E+F A++ +
Sbjct: 1979 LLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQ--AEMFSRQQILH 2036
Query: 3587 AIGRDTDSL--QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEA 3644
+I D L Q Q++D F K+ +L + R + G +D
Sbjct: 2037 SIIIDGQRLLEQGQVDDRDEFNLKLTLLS---NQWQGVIRRAQQRRGIID---------- 2083
Query: 3645 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEII 3704
++ + + R+ +L VE Y + GL ++A L V + ++
Sbjct: 2084 -----SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVF 2138
Query: 3705 NQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764
+Q + + + G+ L+ SA + L+ ++ EI +W + +
Sbjct: 2139 LRQQGSYILTVEA---------------GKQLLLSADSGAEA-ALQAELAEIQEKWKSAS 2182
Query: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824
++ ++ +L L K + + L L ++ ++ P ++ + A+ K
Sbjct: 2183 MRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD--HHEELHAEQMRCKE 2240
Query: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
L+ + + L ++ D + ++E L+ +W EL + + R++Q+
Sbjct: 2241 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
Query: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR-HKALEEDIENHAT 3943
+ L F E + + ++L+ E K++ + + I++ I + K +E+I
Sbjct: 2301 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQE 2355
Query: 3944 DVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFG 4003
+ Q ++G+ L+ + ++ + K+ + R+ + D + L + L +
Sbjct: 2356 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 2415
Query: 4004 EDEVEVLNWLAEVEDKLSSVFVKDF-KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062
++ + WLA +E +L+ V D + + R+ + L +I V + +
Sbjct: 2416 KNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE 2475
Query: 4063 ALLKQ----TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEEL 4118
LL T E IQ+ + R+ +I S + +E+ +L KF Y
Sbjct: 2476 VLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRF 2535
Query: 4119 TGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
WL+ E A + ++ + +++V E L+ +N+ R L
Sbjct: 2536 EDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR 2595
Query: 4179 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 4238
+ L ++V + N+++ + + + + I + +++E A D+ L W+ E +L
Sbjct: 2596 TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL 2655
Query: 4239 ------------------------MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
++L ++EQ + ++K+ +D ++ +DE
Sbjct: 2656 TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE 2715
Query: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
L + E+FG K +++ +++ S+R LE + L + W
Sbjct: 2716 LRRYCQEVFGRVERYHKKLIRLPLPD--DEHDL-----SDRELELEDSAALSDLHWHDRS 2768
Query: 4335 E---LSPWIEETRALIAQLP---------SPA-IDHEQLRQQQEE--MRQLRESIAEHKP 4379
LSP +L P +PA +D L + R L +++ P
Sbjct: 2769 ADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALP 2828
Query: 4380 HIDKLLKIGPQLKELNPEEGEMVEEKYQKA----ENMYAQIKEEVRQRALALDEAVSQST 4435
D EEG+ ++ Y + ++ ++ ++RQ ALD++ Q
Sbjct: 2829 SED--------------EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQ 2874
Query: 4436 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEAL 4495
Q T + S+ P + + + + S+ +++L+ L
Sbjct: 2875 Q-------------TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE---HKL 2918
Query: 4496 KRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWY 4555
K E L G + + D+ WE ++A+A +E++ L+ ++F
Sbjct: 2919 KEEEESLPGFVNLHSTETQTAGVIDR-------WELLQAQALSKELRMKQNLQKWQQFNS 2971
Query: 4556 DMAALLTTIKDTQDIVHDLESPGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRILGA 4613
D+ ++ + DT++ + L+ + I I+ Q++ + +++ D + I +
Sbjct: 2972 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 3031
Query: 4614 DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673
+ A E +++ + +MN W+ + +E L+DA+ + + + L
Sbjct: 3032 EFTQA-DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 3090
Query: 4674 DNTVIKLCTMPPVGTDLNT--VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDE 4731
+N + + P+ ++L+ ++D ++ + K E+ + Q+ + L +L A +
Sbjct: 3091 ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA-EG 3149
Query: 4732 TDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD 4791
TD +E + + + + L ++++ +LE L + ++L SW + E LD
Sbjct: 3150 TDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE--LD 3203
Query: 4792 AQRPIS 4797
+S
Sbjct: 3204 TSGSVS 3209
Score = 121 bits (303), Expect = 2e-26
Identities = 359/1924 (18%), Positives = 763/1924 (39%), Gaps = 281/1924 (14%)
Query: 1809 KLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLEREL--KDLTTLVSQELECVN 1866
+++S++SL+ N+ + + + + + L + K + ++ K LT ++ VN
Sbjct: 1442 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT------VDFVN 1495
Query: 1867 QIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK-VLNQHT 1925
Q ++ ++ +Q +++ D + + L +++ +W ++L +I+ + +L +
Sbjct: 1496 QSVL----QISSQDVESKRSDKTDFAEQLGAMNKSW--QILQGLVTEKIQLLEGLLESWS 1549
Query: 1926 QLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAF 1985
+ E +Q L+ W + L K + D S+ L+ +DL+ + ++ +++ +
Sbjct: 1550 EYENNVQCLKTWFETQEKRL--KQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 1607
Query: 1986 DIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK 2045
+ I +D+S ++ L EL QT A +D + G L+ L+K
Sbjct: 1608 NGLALIQNKKEDVSSI----VMSTLRELG--------QTWANLDHMVGQLK-----ILLK 1650
Query: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRA 2105
++ Q ++ + + S++ +A +L+ + R L A+Q +L++LQDD++ +
Sbjct: 1651 SVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQVDNLQNLQDDLEKQE 1708
Query: 2106 TSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTS 2165
S ++E P L L + ++ L EE Q + +A+
Sbjct: 1709 RSLQKFGSITNQLLKE----CHPPVTETLTNTLKEVNMRWNNLLEEI-AEQLQSSKALLQ 1763
Query: 2166 ALQQETEKSK-AAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGAL 2224
Q+ + SK A + + + + + LL T+ + ++ T + L KG
Sbjct: 1764 LWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL-----KGLG 1818
Query: 2225 DTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQ 2284
D +++ E+L +Q + A A QS Q L QH L EQ
Sbjct: 1819 TVKDSLFFLHELGEQLKQQVDASAAS-------------AIQSDQLSLSQH---LCALEQ 1862
Query: 2285 QMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMH 2344
+ +Q+ TSL Q L + + F + + E+W+ +E+ L+
Sbjct: 1863 ALCKQQ---------TSL--------QAGVL--DYETFAKSLEALEAWIVEAEEILQGQD 1903
Query: 2345 KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLV 2404
SS L ++ +R + L+F +++ E ++ EI
Sbjct: 1904 PSHSSD--LSTIQERMEELKGQM------LKFSSMAPDLDRLNELGYRLPLNDKEI---- 1951
Query: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDT 2464
++++ ++ + S+ T S L L Q+ F + + WM+ +KL +
Sbjct: 1952 -KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAVEI 2007
Query: 2465 VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSI 2524
+ +L++Q A E + Q+ L + D + + D R ++
Sbjct: 2008 SGNYQHLLEQQRAHELFQAEMFSRQQI----LHSIIIDGQRLLEQGQVDDRDEFNLKLTL 2063
Query: 2525 LSH-FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2583
LS+ +Q + +R ++ I Q Q +E E L + + EV +S L S I
Sbjct: 2064 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY----LPMSGLGSVPI 2119
Query: 2584 --QEA--LATNMKLKQDI-ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE 2638
Q+A L ++ K+ + RQ+ S T E + + +ADS A LQ +LAE+ ++++
Sbjct: 2120 PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWK 2179
Query: 2639 Q--LCLQQQEK---------ESSLKKLLPQAEMFEHLSGKLQQFMENKSRML-------- 2679
+ L++Q+K E K + E KL Q + + L
Sbjct: 2180 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCK 2239
Query: 2680 ----ASGNQPDQDITHFF------------QQIQELNLEMEDQQENLDTLEH-LVTELSS 2722
A G+ D D+T I LN +E Q + L H L
Sbjct: 2240 ELENAVGSWTD-DLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQ 2298
Query: 2723 CGFAL-----------DLCQH----------------QDRVQNLRKDFTELQKTVKEREK 2755
G L +LC+ ++ ++ L+KD+ E +E +
Sbjct: 2299 IGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKI 2358
Query: 2756 DASSCQEQLDEFR----------KLVRTFQKW-------------LKETEGSIPPTETSM 2792
E+L + KL + +W LKET ++ + +M
Sbjct: 2359 QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNM 2418
Query: 2793 SAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLE-NLIMEITAPDSQGKTG--SILP 2849
S+ L + H++S L +K + + N + + N E+ + TG S+L
Sbjct: 2419 SS--LRTWLAHIESEL----AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLN 2472
Query: 2850 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909
+ + T + IQ +++ ++ + + ER+ ++ ++ +
Sbjct: 2473 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 2532
Query: 2910 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2969
+ WL+S E + SS K + + +AF ++ + +++ + + L
Sbjct: 2533 SRFEDWLKSSERT--AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL 2590
Query: 2970 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 3029
+ A + K++ E N RW+ + + R+L+ F+ A + WL
Sbjct: 2591 -ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLT 2649
Query: 3030 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPG 3084
E +L + N+ + + VQ +K+ +A +Q+ H ++ + AQG
Sbjct: 2650 EMDLQL---------TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
Query: 3085 DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144
L + +++EL + + E+ ++ ++ + + ++ ++L + A
Sbjct: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760
Query: 3145 RL-----SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYL 3199
L S S +S QP + L +RS+ ++ D + + Y
Sbjct: 2761 DLHWHDRSADSLLSPQPSS-NLSLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY- 2813
Query: 3200 KDELKKRLETV---ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW---LDDK- 3252
+L + LE+ ALP + E+ D+ L+ A+ + + ++R LDD
Sbjct: 2814 --DLSRDLESAMSRALPSED-EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSR 2870
Query: 3253 -QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL---SVPPGE 3308
Q QQ +N I +K + + K L + S S + + L S+P
Sbjct: 2871 FQIQQTENI-IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV 2929
Query: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368
+ + Q + + WE L + ++ R+K +QK Q++ + + W+ D + ++ +
Sbjct: 2930 NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQ 2989
Query: 3369 LR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKA 3425
L+ ++ D +E + + K + V+ R++++ +N + + + ++D +
Sbjct: 2990 LQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLS 3049
Query: 3426 GINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEIFDA-LGS 3481
+N D V L+ G L++ + + F E + + ++ K+++ D+ L +
Sbjct: 3050 QMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA 3109
Query: 3482 QACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL 3541
+ + + + ++ + E+L++ + +V L++ + L+ +A +G+D + + V
Sbjct: 3110 EILQDHHKQLMQIKHELLES-QLRVASLQDMSCQLLVNA-EGTDCLEAKEKVHVIGNRLK 3167
Query: 3542 EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD-----DELDGMGAI----GRDT 3592
+ + V+ +E L ++ S DL DELD G++ GR T
Sbjct: 3168 LLLKEVSRHIKELEKLL-----------DVSSSQQDLSSWSSADELDTSGSVSPTSGRST 3216
Query: 3593 DSLQ 3596
+ Q
Sbjct: 3217 PNRQ 3220
Score = 108 bits (269), Expect = 2e-22
Identities = 253/1468 (17%), Positives = 564/1468 (38%), Gaps = 208/1468 (14%)
Query: 4185 LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI 4244
L K + E ++ R+ +++ A ++Y + + L W+ K K++A G I
Sbjct: 21 LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIE--KAKVLAHGTI 78
Query: 4245 ------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 4298
+L + Q ++++ ID ++M E + + ++ C E+ + ++
Sbjct: 79 AWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSVY--CTEK----MSQQV 130
Query: 4299 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358
L ++ E + + R L+ A + +F ++L +E+ +A L SP +
Sbjct: 131 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQAT---LTSPEVGRL 187
Query: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM-VEEKYQKAENMYAQIK 4417
L++Q + L + KP + + L+ + + + + ++++
Sbjct: 188 SLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQ 247
Query: 4418 EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISD 4477
Q+ + AV Q Q + +++ + + +E + P+ + + +++ IS
Sbjct: 248 HTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 304
Query: 4478 NKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4537
++ +++ Q +L + + L +++ A L E++ + ED+
Sbjct: 305 HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGT----EDLDGELL 360
Query: 4538 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP--------------GIDPSI 4583
V+ + + + + +T + ++ SP ++ I
Sbjct: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
Query: 4584 IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNK 4643
Q +AE ++ + +H + + G +P + ++ +WE L
Sbjct: 421 AYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSATAKLGDLQRSWETLKN 473
Query: 4644 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEF 4703
E+ L +A++ +YQD+LQ++ ++ +KL P G + + Q+ E +
Sbjct: 474 VISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG---RSPESQMAEHQAL 530
Query: 4704 KVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTELKHLWENLGEKIAHRQH 4760
E+ Q E+ +L E ++ ++ D ++ ++ LT L + K + ++
Sbjct: 531 MDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQ 590
Query: 4761 KLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKH 4810
LE L AL +++ +EL SWL T+ LD +P +E +L
Sbjct: 591 LLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD- 649
Query: 4811 HVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRSRLEAMNQCWESVLQKT 4864
+N ++ + V +++ N LLE A D+A L +L + + +
Sbjct: 650 --CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRAL 707
Query: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4924
+++ +Q T Q+ + S+++ + ++ L+ ++ T + + L EL
Sbjct: 708 HDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--WTQQRQSSLQQQKELEQ 763
Query: 4925 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
+L ++ + +G +L+ + + + +L Q+ ME KS E+
Sbjct: 764 ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-----LGMEGEKSSAEDQ 818
Query: 4985 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044
+ + ++++ QEF S +L VL Q +E +++ ++++
Sbjct: 819 MRM--KWESLHQEF--------------STKQKLLQNVLEQEQEQVLYSRP-----NRLL 857
Query: 5045 ELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103
+G L K QD + +LL + +E+V S + G + + ++ ++
Sbjct: 858 ----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSGGAKRQSIHLEQKLYDG 910
Query: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALK 5163
WL+D E L + P++ + L + K + D K
Sbjct: 911 VSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMSEEMD---------K 959
Query: 5164 EKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMD 5212
K L PE+ D LG + V + + + +L++ L F
Sbjct: 960 NKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKV 1019
Query: 5213 ALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGR 5270
+L D Y + +LA +QPV ++ + D K F G +++ +R +
Sbjct: 1020 LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD------AGIIELKRRGDK 1073
Query: 5271 ELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLS 5330
+E +L +L +D + + S++S L Q L + + L + L
Sbjct: 1074 LQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLE 1127
Query: 5331 EAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCI 5389
++ + + + E +Q L+D HKE+ + +E +
Sbjct: 1128 TGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI--------------------- 1166
Query: 5390 TTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAELLEELLAWI--QWAET 5443
+ F +++++A Q + + T L S ++ A L +I W+
Sbjct: 1167 --------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSH- 1217
Query: 5444 TLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK 5503
+ DQ+ + + ++ V++ I E R +DR+T K+ + P + +
Sbjct: 1218 --LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLYQHLKSSLNEYQPKLYQ 1272
Query: 5504 SRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE 5563
G++ L +S S+ ++ ++NQL W L K++ L RLE
Sbjct: 1273 VLDDGKRLLIS--------ISCSDLES-QLNQLGECW-------LSNTNKMSKELHRLET 1316
Query: 5564 -LKEFANFDFDVWRKKYMRWMNHKKSRV 5590
LK + + + + W+ K R+
Sbjct: 1317 ILKHWTRYQSE--SADLIHWLQSAKDRL 1342
Score = 52.4 bits (124), Expect = 1e-05
Identities = 116/685 (16%), Positives = 267/685 (38%), Gaps = 61/685 (8%)
Query: 4827 VNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE 4886
++ A + LE + G L ++ + + + +++ E R +L + ++ +E
Sbjct: 3 LDAAVQKFLEQN-GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 61
Query: 4887 DFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4946
+L+ L+ REQ H L + K + + +K + +
Sbjct: 62 -LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLT-- 118
Query: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
K Q VA L ++ + ++ R L++A +F+ L++ L A+
Sbjct: 119 --SVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ 176
Query: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-- 5064
+L L L LS +H + E + Q ++L Q+ ++ +DVV
Sbjct: 177 ATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKVQAVQLCQSALRIP-----EDVVASL 230
Query: 5065 -IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 5123
+ + + +Q ++ +I++ + A + +Q+ + K L +E A ++ +
Sbjct: 231 PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPV 290
Query: 5124 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDT--------TIRTGRALKEKTL-----LPE 5170
+++ +++ Q+S+H+E + + G Q + T++ A T+ L E
Sbjct: 291 ATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE 350
Query: 5171 DSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE 5230
++ LD L +V + R H L S ++ + + P
Sbjct: 351 GTEDLDGELLPTPSAHPSVVMMTAGRCH-----TLLSPVTEESGEEGTNSEISSPPACRS 405
Query: 5231 DQPV-HGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 5289
PV + D + ++ + + L + + +E E + + K L +
Sbjct: 406 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAK--LGD 463
Query: 5290 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 5349
L W+T+ + KQ L +AL++ + ++D++ + + E L P+ +
Sbjct: 464 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKL---SESPEPGRSP 520
Query: 5350 QSLIDTHKEFMKKVEEKRVDVN--SAVAMGEVILAVCHPDCI--TTIKHWITIIRARFEE 5405
+S + H+ M ++ + ++N + E++ C D ++ +T++ R
Sbjct: 521 ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMST 580
Query: 5406 VLTWAKQHQQRLETALSELVANAEL----------LEELLAWIQWAETTL---IQRDQEP 5452
+ A +Q LE L++ + +EL +W+ + TL + +EP
Sbjct: 581 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP 640
Query: 5453 IPQNIDRVKALIAEHQTFMEEMTRK 5477
+ ++A + + Q + E+ +K
Sbjct: 641 MD-----MEAQLMDCQNMLVEIEQK 660
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 262 bits (669), Expect = 9e-69
Identities = 472/2458 (19%), Positives = 980/2458 (39%), Gaps = 245/2458 (9%)
Query: 2977 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 3036
+ AE+ ++ ++++ R+ R E++ R+++LE+S FQ +L W+ EK +
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQEK--LQI 66
Query: 3037 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKE 3096
DP L + Q+ Q E +A +L+E +++ + ++ ++
Sbjct: 67 ASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTR 123
Query: 3097 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQP 3156
L ++++W L +K+ + +K Q Q+L+Q L E V ++ + AI T
Sbjct: 124 LMELHRQWELLLEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSE 175
Query: 3157 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV----LIGEQYLKDEL-KKRLETVA 3211
E + Q LE ++ E+ ++ + +E++ LI EQ+ ++EL K + + V
Sbjct: 176 E-LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
Query: 3212 LPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQS 3271
Q L+ LA R +L A A Q+F + DE +W+ +K+ A + L +Q+
Sbjct: 235 AAWQRLKGLALQRQGKLFGA-AEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQA 292
Query: 3272 QLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 3331
L+++E ++ L + + AE + L S P + +Q + EL +WE++
Sbjct: 293 LLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ--IQVKREELITNWEQIRTLA 350
Query: 3332 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE 3391
A+R +RL D + Q++ DL W+ + KA ++ + D E+ L R + E
Sbjct: 351 AERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGE 409
Query: 3392 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMT-- 3449
++ + + + L+ + D +R++ +++ A+ E + + E+
Sbjct: 410 IDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDL 469
Query: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE----KLRAQQEVLQALEPQ 3505
Q E N K E ++ D+L S K E L AQ+E + AL+
Sbjct: 470 QLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEF 529
Query: 3506 VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFH 3565
L +ED DA LL + + + + ++ + ++ +
Sbjct: 530 ATKLIQNNHYAMEDVATRRDA--LLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELK 586
Query: 3566 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA---- 3621
V E D +D +LQ +++ + F ++ + I+A E
Sbjct: 587 SWVNEKMKTATD---------EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
Query: 3622 --ECRHMLEEEGTL---DLLGL-KRELEALNKQCGKLTERGKARQ-----EQLELTLGRV 3670
+ H ++E +++ L K+ LEA + KL E + +Q E +EL L V
Sbjct: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEV 697
Query: 3671 EDFYRKLKGLNDATTAA--EEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3728
E D T ++ AL E ++ Q +++D + ++ +Q
Sbjct: 698 EGHLASDDYGKDLTNVQNLQKKHAL-----LEADVAAHQ---------DRIDGITIQARQ 743
Query: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDAL 3788
G D + ++ E + AR+ L + + R +L ++L F+D +
Sbjct: 744 FQDAGH---------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-V 793
Query: 3789 EPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ 3848
E +W+ + E + A+ + V+ +++ + LQ + + + + +G + +
Sbjct: 794 EDEETWIREKEPIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE 852
Query: 3849 SAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908
A E + +L L +W L +KA+ R++ LED L A+Q+ A ++ E
Sbjct: 853 EGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQQYFADANEAESWMREKE 910
Query: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
+ S G + + +H+AL D+ + + + + QS +P +
Sbjct: 911 P-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
Query: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN------WLAEVEDK--- 4019
E + +L + Q++ R+ + D + +LN W EV D+
Sbjct: 970 ELVLALY----DYQEKSPREVTMKKG----------DILTLLNSTNKDWWKVEVNDRQGF 1015
Query: 4020 LSSVFVKDF-------KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
+ + +VK ++++L Q + +AL +E ++ + + + + +KQ
Sbjct: 1016 VPAAYVKKLDPAQSASRENLLEEQGS--IALRQEQIDNQTRITKEAGSVSLRMKQ----- 1068
Query: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
++ Y + K LE++ + F+ EL W+ E E L TS
Sbjct: 1069 ----------VEELYHSLLELGEKRKGMLEKSCKKFMLFREA-NELQQWINEKEAAL-TS 1116
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL---------LELV------ 4177
EQ+ Q++ + +K++ + L +N+V+ L ++ V
Sbjct: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
Query: 4178 --------------PWRAREGLDKLVS------DANEQYKLVSDTIGQRVDEIDAAIQRS 4217
PW++ + V+ + NE+++ + +R + +A
Sbjct: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA-HEV 1235
Query: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK--AFSIDIIRHKDSMDEL 4275
Q++ + AD W+ E K AL D + Q +K F D+ D ++ L
Sbjct: 1236 QRFHRDADETKEWIEE---KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 1292
Query: 4276 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 4335
+ + E + LQEK L Q + ++ +R A+L + L +F + +
Sbjct: 1293 GETAERLIQSHPESAED-LQEKCTELNQAWSSLGKRADQRKAKLGDSHDL-QRFLSDFRD 1350
Query: 4336 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL-------KIG 4388
L WI R L++ ++L + L E EH+ ID + G
Sbjct: 1351 LMSWINGIRGLVSS--------DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402
Query: 4389 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPML 4448
QL +++K + A +++ QR + LD+ + ++ FH E
Sbjct: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL----ELQLFHRDCEQAE 1458
Query: 4449 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508
+ + L + +D + I ++ + + AL+ ++LI
Sbjct: 1459 NWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHY 1517
Query: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQ 4568
A D++++ + LD+ W +KA+ E+ K L + ++F D+ + I +
Sbjct: 1518 AKGDISSRR-NEVLDR----WRRLKAQMIEKRSK-LGESQTLQQFSRDVDEIEAWISEKL 1571
Query: 4569 DIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIF--ACGETEKPE 4626
D DP+ I+ + + + + E + + + +G LI AC +E
Sbjct: 1572 QTASDESYK--DPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA- 1628
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
V+ + + + W+ L + E+ +KL++A + Q +T FD+ + V L
Sbjct: 1629 VKARLAALADQWQFLVQKSAEKSQKLKEANKQ--QNFNTGIKDFDFWLSEVEALLASEDY 1686
Query: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
G DL +V + L + + + ++ + ++ LN Q + ++ + +T + +++ +
Sbjct: 1687 GKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ--VKDKRDTING 1744
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
++ + A R+ KL + L QF +++ SW+ ++LL D ++
Sbjct: 1745 RFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKE-KKLLVGSEDYGRDLTGVQNL 1802
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
KH L+ ++ AH+ ++ V G +L + + ++ RL + W+ + Q
Sbjct: 1803 RKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT-IGKEEIQQRLAQFVEHWKELKQLAAA 1861
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926
R Q+L+ +L+ Q F + +E+ + + L AS+ G + L H +
Sbjct: 1862 RGQRLEESLEYQQ-FVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDF 1919
Query: 4927 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALN 4986
++ N + G+ ++ + ++ + L K + +RK+KL+E +
Sbjct: 1920 TVHKDRVNDVCTNGQDLI--KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN-S 1976
Query: 4987 LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ-IIE 5045
+F +W+ E SL L++V + + + + F + A + + I
Sbjct: 1977 AFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2035
Query: 5046 LDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWK 5105
+ +QL Q I+ S+ RW +++ S R + L +A+ ++ + +
Sbjct: 2036 ITALKDQLLAAKHVQSKA-IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2094
Query: 5106 KLI-------DWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRT 5158
W E+AE L + N ++IK H F+ +L Q ++
Sbjct: 2095 TFAKKASAFNSWFENAEEDLTDPVRC-NSLEEIKALREAHDAFRSSLSSAQADFNQLAEL 2153
Query: 5159 GRALKEKTLLPEDSQKLDNFLGE-VRDKWDTVCGKSVER-------QHKLEEALLFSGQF 5210
R +K + S F E + + W + ER Q + EE +F
Sbjct: 2154 DRQIKSFRVA---SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEF 2210
Query: 5211 MDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGR 5270
A W+ + L + + + + + ++A K +E+ ++ ++ G
Sbjct: 2211 AQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGA 2270
Query: 5271 ELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 5328
+ E D + + L+ +WD + +L + Q LEQ ++ T L E+
Sbjct: 2271 AMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEF 2328
Score = 254 bits (648), Expect = 2e-66
Identities = 416/2043 (20%), Positives = 844/2043 (41%), Gaps = 195/2043 (9%)
Query: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
P G + + +Q+ L+ R + KLE +F R+ + +
Sbjct: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
Query: 3581 ELD-GMGAIGRDTDSLQSQIEDVRLFLNKIH-----VLKLDIEASEAECRHMLEEEGTLD 3634
+L +D +LQ +++ + F ++ ++KLD E +++ EG
Sbjct: 63 KLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD------ETGNLMISEGHFA 116
Query: 3635 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL- 3693
++ L L++Q L E K R++ ++L + + + L+ D + EA+
Sbjct: 117 SETIRTRLMELHRQWELLLE--KMREKGIKLL--QAQKLVQYLRECEDVMDWINDKEAIV 172
Query: 3694 -QWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD 3752
+G ++E + F+ FQ + + ++ +VN LIQ + ++ ++
Sbjct: 173 TSEELGQDLEHVEVLQKKFEEFQTDMAAH-EERVNEVNQFAAKLIQEQHPEEEL--IKTK 229
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812
+E+NA W L QR +L A +F ++ +SW+ + E+L+A+ +
Sbjct: 230 QDEVNAAWQRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDL 287
Query: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872
V+A +++ + L+R L + V L AE R+ QS L+ + I + E L + W ++
Sbjct: 288 ASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ-IQVKREELITNWEQI 346
Query: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE-----KKLANSEPVGTQTAKIQQQ 3927
+ AA R +L D L + ++DF +T K L N++ + + A +
Sbjct: 347 RTLAAERHARLNDSYRLQRF-------LADFRDLTSWVTEMKALINADELASDVAGAEAL 399
Query: 3928 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+ RH+ + +I+ H A + GQ+L + A V EK+ L + + +
Sbjct: 400 LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV-REKLTVLSEERAALLELWEL 458
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
+ +Q + + +LF D +V NW+++ E L L+ D L E +
Sbjct: 459 RRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFL------------LNEDLGDSLDSVEAL 505
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTRYADITVTSSKAL--RTLE 4102
+ + ++ ++++ + + LIQ ++ + TR D ++ AL R +
Sbjct: 506 LKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATR-RDALLSRRNALHERAMR 564
Query: 4103 QARQLATKFQSTY-----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 4157
+ QLA F +EL W+ E + + P+ Q Q+ + + E+
Sbjct: 565 RRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV--QKHQAFEAELS 622
Query: 4158 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 4217
++ +D + + + L+++ + A++ + +++ +K + + + ++ A Q+
Sbjct: 623 ANQSRIDALEKAGQKLIDVNHY-AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
Query: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI---DIIRHKDSMDE 4274
Q D EL W+ E + L + +D T Q +QK ++ D+ H+D +D
Sbjct: 682 QFNRNVEDIEL-WLYEVEGHLASDD---YGKDLTNVQ-NLQKKHALLEADVAAHQDRIDG 736
Query: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
+ + ++ F G +++K E+L+ +YEA+ R +L + + + Q + E
Sbjct: 737 I-TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS-LRLQQLFRDVE 794
Query: 4335 ELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 4394
+ WI E + A + D ++ ++ + L+ IA H+P I K +
Sbjct: 795 DEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRI----------KAV 843
Query: 4395 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 4454
+ MVEE + AE++ A++ E+ Q+ AL SQ Q E + +
Sbjct: 844 TQKGNAMVEEGHFAAEDVKAKL-HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 4455 SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG---EELIGRSQGADK 4511
S +R I D + D SA L+K + L G + L ++Q +
Sbjct: 903 ESWMREKEPIVGSTDYGK----DEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQ 958
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLEL---AEKFWYDMAALLTTIKDTQ 4568
+A + + + ++ ++ + E +K D+L L K W+ + + D Q
Sbjct: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-----VNDRQ 1013
Query: 4569 DIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI----RILGADLIFACGETEK 4624
V +DP+ Q + E + EE + E I RI E
Sbjct: 1014 GFVPAAYVKKLDPA----QSASRENLLEEQGSIALRQEQIDNQTRIT----------KEA 1059
Query: 4625 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4684
V + ++ + +L + ++R LE + + + +++ + W++ L T
Sbjct: 1060 GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAAL-TSE 1117
Query: 4685 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE------LMLKKAT--------- 4729
VG DL V+ + +F+ ++ + ++ +N E LM ++
Sbjct: 1118 EVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYG 1177
Query: 4730 ----DETDRDIIR---------------EPLTELKHLWENLGEKIAHRQHKLEGALLALG 4770
DETD + EL W +L +++A + +L G+ +
Sbjct: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQ 1236
Query: 4771 QFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830
+F +E W+ + L+ D ++ KH + D+ A V ++ +
Sbjct: 1237 RFHRDADETKEWIEEKNQALNTDN-YGHDLASVQALQRKHEGFERDLAALGDKVNSLGET 1295
Query: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890
L++S + A L+ + +NQ W S+ ++ ++R+ +L + Q F S+ D +
Sbjct: 1296 AERLIQSHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMS 1353
Query: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS 4950
+ + +S+ + + A L+ H E +++ A+ T+ G+ +L
Sbjct: 1354 WINGIRGLVSSDELAKDVTG-AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GH 1410
Query: 4951 GSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLN 5010
+ + +Q + +L+Q+ + +R+ L++ L L F ++ NW+ E LN
Sbjct: 1411 YASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQL-FHRDCEQAENWMAAREAFLN 1469
Query: 5011 IASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQ--KQDVVLIKNL 5068
L++V + I++H+ F +N ++I L +QL K D+ +N
Sbjct: 1470 TEDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRN- 1527
Query: 5069 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDP 5128
V RW ++ + IE+ L +++ +QF ++ W+ +E + E DP
Sbjct: 1528 --EVLDRWRRLKAQMIEKRSKLGESQT-LQQFSRDVDEIEAWI--SEKLQTASDESYKDP 1582
Query: 5129 DKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDT 5188
I+ + KH+ F+ L I G +L E+ + L + D+W
Sbjct: 1583 TNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQF 1642
Query: 5189 VCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDA 5247
+ KS E+ KL+EA F ++ WL +VE LA + +G DL V NL+
Sbjct: 1643 LVQKSAEKSQKLKEANK-QQNFNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKK 1699
Query: 5248 HKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR 5307
H++ + ++ ++ L L+ +S DT+ VK + ++ R+ + ++ S++++
Sbjct: 1700 HQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAK 1759
Query: 5308 LEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR 5367
L ++ + + FRD + W+ E ++ L D +Q+L HK ++
Sbjct: 1760 LNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1817
Query: 5368 VDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARF----EEVLTWAKQHQQRLETAL-- 5421
+ + G+ + D T K I A+F +E+ A QRLE +L
Sbjct: 1818 PAIQGVLDTGKKL-----SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEY 1872
Query: 5422 SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDV 5481
+ VAN +EE AWI T + D + ++ L+ +H+ F + T + V
Sbjct: 1873 QQFVAN---VEEEEAWINEKMTLVASED---YGDTLAAIQGLLKKHEAFETDFTVHKDRV 1926
Query: 5482 DRV 5484
+ V
Sbjct: 1927 NDV 1929
Score = 190 bits (482), Expect = 4e-47
Identities = 440/2380 (18%), Positives = 920/2380 (38%), Gaps = 297/2380 (12%)
Query: 2035 LQQMEQEALVKTLQKQQNTCH-QQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 2093
L++M ++ +K LQ Q+ + ++ ED+ W+ E + + QDL ++ Q
Sbjct: 135 LEKMREKG-IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEE---LGQDLEHVEVLQKK 190
Query: 2094 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR 2153
++ Q D+ EE +++ ++E+ H +E + Q+E
Sbjct: 191 FEEFQTDMAAH---------------EERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVN 234
Query: 2154 VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ 2213
A + L+ ALQ++ + AA E+ + +D + W+ EQ
Sbjct: 235 AAWQRLKGL---ALQRQGKLFGAA-EVQRFNRDVDETISWIKE--------------KEQ 276
Query: 2214 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 2273
L + L + + + E L++ ++ + + L ++
Sbjct: 277 LMASDDFGRDLASVQALL---RKHEGLERDLAALEDKVKALCAEADRL------------ 321
Query: 2274 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 2333
Q H L+ + Q+ +++L EQ T A+ A L LQ+FL D ++ SW+
Sbjct: 322 QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY----RLQRFLADFRDLTSWV 377
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
K L N + S +LL R ++ +H+ + SGQ +L
Sbjct: 378 TEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL-------- 428
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ------FQNSADSLQ 2447
G+ D+++ E+ T L + L + QY Q F + +
Sbjct: 429 -----AAGHYASDEVR---EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
Query: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507
WM EA LL++ + ++ L + ++ L+ + + L + A +++
Sbjct: 481 NWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN 537
Query: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES--LESLLQSIGE 2565
D V D++LS +L R + L + Q ++S L+S + +
Sbjct: 538 HYAMED---VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594
Query: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
+ K S+L G +Q+ A +L + +R + +A ++++ D A
Sbjct: 595 TATDEAYKDPSNLQ-GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA-- 651
Query: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQP 2685
++ EV +++L + K L++ Q + F ++ ++ LAS +
Sbjct: 652 ---RMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVEDIELWLYEVEGHLASDDY- 706
Query: 2686 DQDITHFFQQIQE----LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2741
+D+T+ Q +Q+ L ++ Q+ +D + + G H D +N++K
Sbjct: 707 GKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAG-------HFD-AENIKK 757
Query: 2742 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTF------QKWLKETEGSIPPTETSMSAK 2795
L + ++ + +++L + +L + F + W++E E T
Sbjct: 758 KQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLI 817
Query: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855
++ ++ ++L + A ++ + KG ++
Sbjct: 818 GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE------------------------- 852
Query: 2856 GSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2915
G+ +D ++ + ++N K+E L +R++ L+ L + ++ +AN W
Sbjct: 853 ---EGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESW 905
Query: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA---------- 2965
+ KE ++ S D E A + ++A +++L IQ ++E
Sbjct: 906 MREKEPIVGSTDYGKDEDSAE---ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962
Query: 2966 --------LAGLLVTYPNSQEAENWKK---IQEELNSRWERATEVTVARQRQLEESASHL 3014
L L Y E K I LNS + +V V RQ A+++
Sbjct: 963 TDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEV-NDRQGFVPAAYV 1021
Query: 3015 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
A+S R L+E++ + + + + + V +K+ E +L E
Sbjct: 1022 KKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGE 1081
Query: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQD 3134
+G+L + + + Q IN+K LT + + ++Q V ++ + +D
Sbjct: 1082 KRKGMLEKSCKKFMLFREANELQQWINEKEAALTSE--EVGADLEQVEVLQKKFDDFQKD 1139
Query: 3135 LS------EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCD 3188
L + + V + L + ++ + +AV+QQ E+ + + + + K A
Sbjct: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETDSKTASPW-K 1193
Query: 3189 ELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 3248
+++ + +K+ E + L+ LA +R ++L + Q+F + DE + W
Sbjct: 1194 SARLMVHTVATFNSIKELNER----WRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEW 1248
Query: 3249 LDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE 3308
+++K +Q L +Q+ +++E F++ L + E L+ S P E
Sbjct: 1249 IEEK-NQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP--E 1305
Query: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368
LQ + EL W L K+ R+++L D Q++ DL+ WI + +S
Sbjct: 1306 SAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSS 1364
Query: 3369 LRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE------------AD 3416
+ D E+ L R + E++ R + L+ D
Sbjct: 1365 DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILD 1424
Query: 3417 EDGIRDEKAGINQNMDAVTEELQAKTGSLE-EMTQRLREFQESFKNIEKKVEGAKHQLEI 3475
++ EKA + + M + + L+ + + E + +E+F N E K +
Sbjct: 1425 QERADLEKAWVQRRM-MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDS------- 1476
Query: 3476 FDALGSQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3534
D++ + +++ +K + Q+E + AL+ D L G S +++L +
Sbjct: 1477 LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWR 1534
Query: 3535 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDS 3594
+ + +E + ++ + + + + + + E +D +D +
Sbjct: 1535 RLKAQMIEKRSKLGESQTLQQFSRD-VDEIEAWISEKLQTASDESY---------KDPTN 1584
Query: 3595 LQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL--DLLGLKRELEALNKQCGKL 3652
+QS+ + + F ++H D + + L E G +K L AL Q L
Sbjct: 1585 IQSKHQKHQAFEAELHA-NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFL 1643
Query: 3653 TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL--QWVVGTEVEIINQQLAD 3710
++ + ++L+ + ++F G+ D E EAL G ++ +N L
Sbjct: 1644 VQKSAEKSQKLK-EANKQQNFNT---GIKDFDFWLSEVEALLASEDYGKDLASVNNLLKK 1699
Query: 3711 FKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQR 3770
++ + + + + +L+ +N L+ S+ D ++ + IN R+ + A R
Sbjct: 1700 HQLLEAD-ISAHEDRLKDLNSQADSLMTSSA--FDTSQVKDKRDTINGRFQKIKSMAASR 1756
Query: 3771 IAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLD 3830
A+L E+ F+D ++ SW+ + ++L+ + + V+ ++ K L+ L
Sbjct: 1757 RAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELA 1814
Query: 3831 DRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLA 3890
+ + + G +++ + +E+I +L W EL AAAR ++LE+ L
Sbjct: 1815 AHEPAIQGVLDTGKKLSDDNTIG-KEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEY- 1872
Query: 3891 KQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVK 3950
+QF E +++ + L SE G A IQ + +H+A E D H V+
Sbjct: 1873 QQFVANVEEEEAWIN-EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCT 1931
Query: 3951 IGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVL 4010
GQ L + E+ + S K+ L + S+++ ++ A LD+ + + + +V V
Sbjct: 1932 NGQDLIKKNNHHEENI-SSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADV-VE 1989
Query: 4011 NWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV--DQAIKNGQALLKQT 4068
+W+ E E+ L + D+ +D+ L +E + + I N AL Q
Sbjct: 1990 SWIGEKENSLKT---DDYGRDL---SSVQTLLTKQETFDAGLQAFQQEGIANITALKDQL 2043
Query: 4069 TGEEVL---LIQEKLDGIKTRYADITVTSSKALRTLEQAR-------QLATKFQSTYEEL 4118
+ + I+ + + R++ + S+ + L +A+ L F
Sbjct: 2044 LAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAF 2103
Query: 4119 TGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL-- 4176
W EE+L T + + E+I ++ + + + + + E+ R +
Sbjct: 2104 NSWFENAEEDL-TDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2162
Query: 4177 ----VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS-------QQYEQAAD 4225
W E L+ E ++ + I +R E+ +R Q++ Q A+
Sbjct: 2163 ASNPYTWFTMEALE-------ETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2215
Query: 4226 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285
A W+ ET+ L+ + E +QL+ K +I + + ++ E G
Sbjct: 2216 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKI-----EDLGA 2270
Query: 4286 CGEE----QKTVLQEKTESLIQQYEAISLLNSERYARLER 4321
EE + T L QQ++ + L LE+
Sbjct: 2271 AMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2310
Score = 165 bits (417), Expect = 1e-39
Identities = 330/1802 (18%), Positives = 724/1802 (40%), Gaps = 219/1802 (12%)
Query: 3852 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3911
L E I + + + R+ + R+++LED + F AE + ++ EK
Sbjct: 9 LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRF-QFFQRDAEELEKWIQ--EKLQ 65
Query: 3912 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3971
S+ +Q ++ +H+A E +++ ++ + + + G + S A + + + +
Sbjct: 66 IASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
Query: 3972 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 4031
+ L ++ + ++ K L QA + E E +V++W + DK + V ++ QD
Sbjct: 126 E-LHRQWELLLEKMREKGIKLLQAQKLVQYLRECE-DVMDW---INDKEAIVTSEELGQD 180
Query: 4032 VLH--------RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083
+ H + +A +EE VN + A L Q E LI+ K D +
Sbjct: 181 LEHVEVLQKKFEEFQTDMAAHEERVNE-------VNQFAAKLIQEQHPEEELIKTKQDEV 233
Query: 4084 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIP 4143
+ + + + L A ++ +F +E W++E +E+L S +
Sbjct: 234 NAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETISWIKE-KEQLMASDDFGRDLASVQ 291
Query: 4144 QFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVS 4200
++ + L++++ + + + L + P A + ++L+++ + L +
Sbjct: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
Query: 4201 DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA 4260
+ + D R Q++ +WV E K + A D+ + + +A
Sbjct: 352 ERHARLNDSY-----RLQRFLADFRDLTSWVTEMKALINA--------DELASDVAGAEA 398
Query: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320
+ RH++ E+ +H F + E + +L + + E +++L+ ER A LE
Sbjct: 399 L---LDRHQEHKGEIDAHEDS-FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
Query: 4321 RAQVLVNQ---------FWETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQ 4369
++ Q F+ E++ W+ + A + L E L ++ E+ +
Sbjct: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
Query: 4370 LRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 4429
S++ + I L + +L + N E V + + + + +RA+
Sbjct: 515 ---SLSAQEEKITALDEFATKLIQNNHYAMEDVATR----RDALLSRRNALHERAMRRRA 567
Query: 4430 AVSQSTQITEFH---DKIEPML-ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVEL 4485
++ S + +F D+++ + E ++ + P ++ + +++ EL
Sbjct: 568 QLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP------SNLQGKVQKHQAFEAEL 621
Query: 4486 EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED---------IKARA 4536
Q +AL++ G++LI + A ++AA+ +++++ W+ IK R
Sbjct: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAAR-----MNEVISLWKKLLEATELKGIKLRE 676
Query: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4596
++ +F +E E + Y++ L + +D+ + Q ++ + E
Sbjct: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN------------VQNLQKKHALLE 724
Query: 4597 ETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4656
H++ + A G + ++K + + +E L + R +KL D++
Sbjct: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
Query: 4657 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4716
+ ++D ++ W+ + G DL V++ L + + + E+ + ++
Sbjct: 785 RLQQLFRD-VEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 4717 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHAL 4776
+ +G M+++ + ++ L EL WE L K + R+ LE +L A F A
Sbjct: 843 VTQKGNAMVEEGHFAAED--VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA- 899
Query: 4777 EELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLE 4836
E SW+ E ++ + D E L KH L +D+ A+ ++++ + + +
Sbjct: 900 NEAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQ 958
Query: 4837 SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRME 4896
A D + + + A+ E ++ ++ + + L ++E
Sbjct: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE---------- 1008
Query: 4897 SQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR--DDSGSGS 4954
+ G +P ++LD +Q ++E N L ++G + L D+ +
Sbjct: 1009 ----VNDRQGFVPAAYVKKLDP-----AQSASRE---NLLEEQGSIALRQEQIDNQTRIT 1056
Query: 4955 KTEQSVAL----LEQKWHVVSSKMEERKSKLEEALNLATEFQ--NSLQEFINWLTLAEQS 5008
K SV+L +E+ +H + E+RK LE++ F+ N LQ++IN A S
Sbjct: 1057 KEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
Query: 5009 LNIASPPSLI-----------------------LNTVLSQIEEHKVFANEVNAHRDQII- 5044
+ + + +N V +E + A EV A + Q +
Sbjct: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
Query: 5045 ------ELD-QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
E D +T + K V N + + RW + Q + ER + L A +
Sbjct: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHE-V 1235
Query: 5098 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157
++FH + +W+E+ L+++ +D ++ KH+ F++ L ++
Sbjct: 1236 QRFHRDADETKEWIEEKNQALNTD-NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGE 1294
Query: 5158 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
T L + PE ++ L E+ W ++ ++ +R+ KL ++ +F+ + L
Sbjct: 1295 TAERLIQSH--PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
Query: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277
+ W+ + ++ D+ + D+ L++ H+ + E+ R GT Q ++ G++L+ +
Sbjct: 1352 MSWINGIRGLVSSDE-LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
Query: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
+ +K +L L + K V ++ L+Q L + ++F W++ E L
Sbjct: 1411 YASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAFLN 1469
Query: 5338 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 5397
D +++++LI H++F K + + + + A + ++A H +
Sbjct: 1470 TEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGH--------YAKG 1520
Query: 5398 IIRARFEEVLT-WAKQHQQRLETALSELVANAEL------LEELLAWIQWAETTLIQRDQ 5450
I +R EVL W + Q +E S+L + L ++E+ AWI + +Q
Sbjct: 1521 DISSRRNEVLDRWRRLKAQMIEKR-SKLGESQTLQQFSRDVDEIEAWI----SEKLQTAS 1575
Query: 5451 EPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRK 5510
+ ++ +++ +HQ F E+ + DR+ N IE+ G +
Sbjct: 1576 DESYKDPTNIQSKHQKHQAFEAEL---HANADRIRGVIDMGN------SLIERGACAGSE 1626
Query: 5511 SLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANF 5570
+A R+ L+ +WQ + + E+ +KL +A + +F
Sbjct: 1627 ----------------DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1670
Query: 5571 DF 5572
DF
Sbjct: 1671 DF 1672
Score = 164 bits (416), Expect = 2e-39
Identities = 444/2388 (18%), Positives = 912/2388 (38%), Gaps = 283/2388 (11%)
Query: 2212 EQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAF 2271
E+L EK + + + Y KL K HQ ++ Q A A
Sbjct: 54 EELEKWIQEKLQIASDENYKDPTNLQGKLQK--------HQAFEAEVQ----ANSGAIVK 101
Query: 2272 LDQHGHNLTPE---EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ-DELQKFLQDHK 2327
LD+ G+ + E + ++ +L EL Q+ L + K ++ LQ +L ++L++ +
Sbjct: 102 LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMRE--KGIKLLQAQKLVQYLRECE 159
Query: 2328 EFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDM 2387
+ W+ E + + G E + L K+ F D+ +H+ + V K++
Sbjct: 160 DVMDWINDKEA-IVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE 218
Query: 2388 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 2447
++ +E L+K K + + L + L + +F D
Sbjct: 219 QHPEEE---------LIKTKQDEVNAAWQRLKGLALQRQGKL-FGAAEVQRFNRDVDETI 268
Query: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507
+W++ E + + SD D +Q L + L+ +LA + +K++ + + ++
Sbjct: 269 SWIKEKE---QLMASDDFGRDLASVQALLRKHEGLERDLAALE---DKVKALCAEADRLQ 322
Query: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567
+Q + ++++++ + AER + L + + Q L + E++
Sbjct: 323 QSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMK 381
Query: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQ 2627
+ +++S +G + L + + K +I + S ++ E + + V +
Sbjct: 382 ALINADELASDVAGA-EALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVRE 440
Query: 2628 GKLAEVSQR------FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2681
KL +S+ +L QQ E+ L+ E ++ K + F+ N
Sbjct: 441 -KLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN------- 492
Query: 2682 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQ----DRVQ 2737
+D+ ++ L + ED +++L E +T L FA L Q+ + V
Sbjct: 493 -----EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE--FATKLIQNNHYAMEDVA 545
Query: 2738 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2797
R + + ER A + QL + L + F+ + EL
Sbjct: 546 TRRDALLSRRNALHER---AMRRRAQLADSFHLQQFFR-----------------DSDEL 585
Query: 2798 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2857
+ + D A K + N +G ++ E +Q + + L G +
Sbjct: 586 KSWVNEKMKTATDEAYK----DPSNLQGKVQKHQAFEAELSANQSRIDA-LEKAGQKLID 640
Query: 2858 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2917
VN H KD E+ M++V ++KL + L+ N+ ++ ++ + WL
Sbjct: 641 VN--HYAKD--EVAARMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVEDIELWLY 695
Query: 2918 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2977
E L S D T + ++ K L E + + ++ + G+ + Q
Sbjct: 696 EVEGHLASDDYGKDLTNVQNLQ-----KKHALLEAD-----VAAHQDRIDGITIQARQFQ 745
Query: 2978 EA-----ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
+A EN KK QE L +R+E E VAR+++L +S F+ E + W+ EKE
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE-ETWIREKE 804
Query: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ---HEQLNEAAQGILTGPGDVSL- 3088
P++ N VQ +LK+ +A + + HE +A +T G+ +
Sbjct: 805 -------PIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKA----VTQKGNAMVE 852
Query: 3089 ----STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144
+ V+ +L +NQKW + L +++SQ Q + S Q Q+ D +E + +
Sbjct: 853 EGHFAAEDVKAKLHELNQKW----EALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
Query: 3145 RLSV--QSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
+ + + ++ + L++ + SDL ++ + + DE
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP--TDDE 966
Query: 3203 LKKRLETVALPLQGLEDLAADRINR----LQAALASTQQFQQMFDELRTWLDDKQSQQAK 3258
K L L L ++ + + + L ST + D + ++D+Q
Sbjct: 967 TGKEL---VLALYDYQEKSPREVTMKKGDILTLLNSTNK-----DWWKVEVNDRQG--FV 1016
Query: 3259 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLV 3318
KL+ QS +EN L + GS + + ++ Q+
Sbjct: 1017 PAAYVKKLDPAQSASREN------LLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVE 1070
Query: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQL 3378
EL + EL +K R+ L+ +K ++ +L WI + +A ++ V D Q+
Sbjct: 1071 ELYHSLLELGEK---RKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQV 1126
Query: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV---- 3434
E + +++ S L+ +N A+ + + +G+ E+ Q +
Sbjct: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAE------DLESEGLMAEEVQAVQQQEVYGMMP 1180
Query: 3435 TEELQAKT-----------------GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF- 3476
+E +KT S++E+ +R R Q+ + ++ G+ H+++ F
Sbjct: 1181 RDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFH 1239
Query: 3477 -------------------DALGSQACSNKNLE-KLRAQQEVLQALEPQVDYLRNFTQGL 3516
D G S + L+ K + L AL +V+ L + L
Sbjct: 1240 RDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERL 1299
Query: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA 3576
++ P+ AE Q++ E+ Q +S + + +G H ++ S
Sbjct: 1300 IQSHPE---------SAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH-DLQRFLSDFR 1349
Query: 3577 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA------ECRHMLEEE 3630
DL ++G+ + +D L + L + + +I+A + L
Sbjct: 1350 DLMSWINGIRGL-VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH 1408
Query: 3631 GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3690
G +K++L+ L+++ L + R+ L+ L ++ F+R + + AA EA
Sbjct: 1409 GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAEN-WMAAREA 1466
Query: 3691 EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE 3750
G ++ + + + F K ++ + K+ + LI A +
Sbjct: 1467 FLNTEDKGDSLDSVEALIKKHEDFDK-AINVQEEKIAALQAFADQLI--AAGHYAKGDIS 1523
Query: 3751 HDMEEINARWNTLNKKVAQRIAQLQEA--LLHCGKFQDALEPLLSWLADTEELIANQKPP 3808
E+ RW L ++ ++ ++L E+ L + D +E +S T + + P
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
Query: 3809 SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESR 3868
+ + K K Q E + L D + +DM I + A + + +L +L +
Sbjct: 1584 NIQSKHQKHQAFEAE-LHANADRIRGVIDM---GNSLIERGACAGSEDAVKARLAALADQ 1639
Query: 3869 WTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI 3928
W L+ K+A + ++L++ + F+ + +LS E LA SE G A + +
Sbjct: 1640 WQFLVQKSAEKSQKLKE-ANKQQNFNTGIKDFDFWLSEVEALLA-SEDYGKDLASVNNLL 1697
Query: 3929 IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3988
+H+ LE DI H + SL + +S + + +K D++ R+ +I+ +
Sbjct: 1698 KKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQKIKSMAASR 1756
Query: 3989 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH--ADHLALNEE 4046
A L+++ F D + +W +++K V +D+ +D+ Q+ H L E
Sbjct: 1757 RAKLNES-HRLHQFFRDMDDEESW---IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAE 1812
Query: 4047 IVNRKKNVDQAIKNGQALLKQTT-GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 4105
+ + + + G+ L T G+E IQ++L + ++ ++ + LE++
Sbjct: 1813 LAAHEPAIQGVLDTGKKLSDDNTIGKEE--IQQRLAQFVEHWKELKQLAAARGQRLEESL 1870
Query: 4106 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 4165
+ +F + EE W+ E + L S T I ++ + + + H+ D
Sbjct: 1871 EY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHK---DR 1925
Query: 4166 VNEVSRALLELVPW--RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 4223
VN+V +L+ E + + N + + QR ++D Q+
Sbjct: 1926 VNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN-SAFLQFNWK 1984
Query: 4224 ADAELAWVAETK---------RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
AD +W+ E + R L ++ + +Q+ A LQ AF + I + ++ +
Sbjct: 1985 ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ---AFQQEGIANITALKD 2041
Query: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
+ E + L ++ L+ A E + + + L F +
Sbjct: 2042 QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKAS 2101
Query: 4335 ELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 4394
+ W E + P E+++ +E R S++ + ++L ++ Q+K
Sbjct: 2102 AFNSWFENAEEDLTD-PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSF 2160
Query: 4395 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 4454
+ E + +++ +++R L L + + E +DK+ N
Sbjct: 2161 RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQ----EENDKLRQEFAQHANA 2216
Query: 4455 SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL 4502
+ + + R + D E L+ EA KR+ +E+
Sbjct: 2217 FHQW---------IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEI 2255
Score = 134 bits (336), Expect = 4e-30
Identities = 358/1932 (18%), Positives = 750/1932 (38%), Gaps = 264/1932 (13%)
Query: 1933 DLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFIS 1992
+L++WV K + + + D +L +Q+++ + ++ ++++DAL Q I
Sbjct: 584 ELKSWVNEK---MKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLI- 639
Query: 1993 EHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQN 2052
D++ ++ +NE+ ++ +LE T E + + QQ
Sbjct: 640 ----DVNHYAKDEVAARMNEVISLWKKLLEAT--------------ELKGIKLREANQQQ 681
Query: 2053 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN----QSDLKDLQDDIQNRATSF 2108
++ +ED+ W+ + E LA ++ LQK ++D+ QD I T
Sbjct: 682 QFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG-ITIQ 740
Query: 2109 ATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQ 2168
A +D F EN +++K +YEAL+E +++L +++ LQ
Sbjct: 741 ARQFQDAGHFDAEN-----------IKKKQEALVARYEALKEPMVARKQKLADSL--RLQ 787
Query: 2169 QETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTD 2228
Q + + K+ I AS +G
Sbjct: 788 QLFRDVEDEETWIREKEPI----------------------------AASTNRG-----K 814
Query: 2229 GYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ 2288
+GV +K +A E+ + TQ A +++ GH + ++
Sbjct: 815 DLIGVQNLLKK-------HQALQAEIAGHEPRIKAVTQKGNAMVEE-GHFAAED----VK 862
Query: 2289 QKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKEFESWLERSEKELENMHKG 2346
KL EL +++ A++ ++ Q L+D L Q++ D E ESW+ R ++ +
Sbjct: 863 AKLHELNQKWEALKAKAS---QRRQDLEDSLQAQQYFADANEAESWM-REKEPIVGSTDY 918
Query: 2347 GSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPS--EIGNLV 2404
G ++ +LLK+ + D+ ++ + Q + + S ++ P+ E G +
Sbjct: 919 GKDEDSAEALLKKHEALMSDLSAYGSSI-------QALREQAQSCRQQVAPTDDETGKEL 971
Query: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ-FQNSADSLQAWMQACEANVEKLLSD 2463
L D E+ + + G L +L ++ + Q ++ A A V+KL
Sbjct: 972 VLALYDYQEK--SPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA--AYVKKLDPA 1027
Query: 2464 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2523
AS +L+EQ + L++E ++Q + K G + + V+E S
Sbjct: 1028 QSASRENLLEEQGSIA--LRQEQIDNQTRITK----------EAGSVSLRMKQVEELYHS 1075
Query: 2524 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2583
+L + +R +L+K+ + +E+ E L Q I E E L ++V G
Sbjct: 1076 LLELGE-------KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV-----GAD 1122
Query: 2584 QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQL--- 2640
E + K D + + E+ + + + E +S +G +AE Q +Q
Sbjct: 1123 LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES------EGLMAEEVQAVQQQEVY 1176
Query: 2641 -CLQQQEKESSLKKLLPQAEMFEHLSG-------------KLQQFMENKSRMLASGNQPD 2686
+ + E +S A + H LQQ E +S++L S +
Sbjct: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH--- 1233
Query: 2687 QDITHFFQQIQELN--LEMEDQQENLDTLEHLVTELSSC-----GFALDLCQHQDRVQNL 2739
++ F + E +E ++Q N D H + + + GF DL D+V +L
Sbjct: 1234 -EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 1292
Query: 2740 RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEK 2799
+ ++ ++ + A QE+ E + + K + + + + +L++
Sbjct: 1293 GE---TAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLG------DSHDLQR 1343
Query: 2800 QIEHLKSLLDDW-------ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVG 2852
+ + L+ W S L +++ LE T D++ T G
Sbjct: 1344 FLSDFRDLM-SWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402
Query: 2853 SSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
+ + Y + EI+ + ++ + L +R+ L L ++ H++
Sbjct: 1403 QQLLAHGHYAS----PEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQA 1457
Query: 2913 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2972
W+ ++E L + D S ++V+A + ++ F + KI + +A A L+
Sbjct: 1458 ENWMAAREAFLNTEDKGDS---LDSVEALIKKHEDFDKAINVQEEKIAAL-QAFADQLIA 1513
Query: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
+ + + + E L+ RW R + ++ +L ES + L F ++ W+ EK
Sbjct: 1514 AGHYAKGDISSRRNEVLD-RWRRLKAQMIEKRSKLGESQT-LQQFSRDVDEIEAWISEK- 1570
Query: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 3092
+ DP + ++ Q+ Q E A + + + ++ G + S
Sbjct: 1571 -LQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIE-RGACAGSEDA 1628
Query: 3093 VQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAI 3152
V+ L ++ +W L K +S ++ +A K + ++D + V + L
Sbjct: 1629 VKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEV-EALLASEDY 1686
Query: 3153 STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 3212
+V L++ + +D+ + +K+ + D S++ + ++K + +T+
Sbjct: 1687 GKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQAD--SLMTSSAFDTSQVKDKRDTING 1744
Query: 3213 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 3272
Q ++ +AA R +L + Q F+ M DE +W+ +K+ L +Q+
Sbjct: 1745 RFQKIKSMAASRRAKLNESHRLHQFFRDMDDE-ESWIKEKKLLVGSE-DYGRDLTGVQNL 1802
Query: 3273 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTA 3332
++++ + L H + + ++ G+ L G+E+ +Q +L + HW+EL + A
Sbjct: 1803 RKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE--IQQRLAQFVEHWKELKQLAA 1860
Query: 3333 DRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEV 3392
R RL++ ++ Q++ +VE+ WI + ++ ++ L + +A +
Sbjct: 1861 ARGQRLEESLE-YQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDF 1919
Query: 3393 EKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRL 3452
+ + + + LI + E+ I + G+N + + + + L+E + L
Sbjct: 1920 TVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFL 1979
Query: 3453 R-------------EFQESFKNIE-----KKVEGAKHQLEIFDALGSQACSNKNLEKLRA 3494
+ E + S K + V+ + E FDA G QA + + + A
Sbjct: 1980 QFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA-GLQAFQQEGIANITA 2038
Query: 3495 QQEVL--------QALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3545
++ L +A+E + ++ ++Q L A + + FL +
Sbjct: 2039 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2098
Query: 3546 RVNSGCVMMENKLEGI-GQFHCRVREMFSQLADLDD----ELDGMGAIGRDTDSLQSQIE 3600
+ ++ EN E + C E L + D L A L QI+
Sbjct: 2099 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2158
Query: 3601 DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQ 3660
R+ N +EA E R+ L + +RELE L K+ + E K RQ
Sbjct: 2159 SFRVASNP--YTWFTMEALEETWRN-------LQKIIKERELE-LQKEQRRQEENDKLRQ 2208
Query: 3661 EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVD 3720
E + + L D + EE+ L+ +++E + + +++
Sbjct: 2209 EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLE----SQLEATKR--------KHQEIR 2256
Query: 3721 PLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK---KVAQRIAQLQEA 3777
++ +L+++ LG + ++ D + EH + +W+ L++ ++ + Q +A
Sbjct: 2257 AMRSQLKKIEDLGAAMEEAL--ILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQA 2314
Query: 3778 LLHCGKFQDALE 3789
G ++AL+
Sbjct: 2315 RNTTGVTEEALK 2326
Score = 99.0 bits (245), Expect = 1e-19
Identities = 333/1808 (18%), Positives = 690/1808 (38%), Gaps = 251/1808 (13%)
Query: 1817 LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEV 1876
L N++ K+ LE ++A QD + + R+ +D ++ ++ + ++++ + +
Sbjct: 710 LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEAL 769
Query: 1877 PAQLLKALEK--DAKNLQKSLSSVSD--TW-------------NSRLLHFQNAVEIEKTK 1919
++ +K D+ LQ+ V D TW L+ QN ++K +
Sbjct: 770 KEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNL--LKKHQ 827
Query: 1920 VLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQ 1979
L ++ G ++A N ++ +E L+ Q++E LK ++R+
Sbjct: 828 ALQ--AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQD 885
Query: 1980 LDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQME 2039
L+ Q+F + + ++ ++ + +D E + +AL L
Sbjct: 886 LEDSLQAQQYFADANEAESWMREKEPIVGSTD--YGKDEDSAEALLKKHEALMSDLSAYG 943
Query: 2040 QEALVKTLQKQQNTCHQQLEDLCSWVG-QAERALAGHQGRTTQQDLSALQKNQSDLKDLQ 2098
++ L++Q +C QQ+ G + AL +Q ++ ++ + + D+ L
Sbjct: 944 SS--IQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPRE----VTMKKGDILTLL 997
Query: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE----QYEALQEETRV 2154
+ + V D +GF+ K +A RE L + + + E + +TR+
Sbjct: 998 NSTNK--DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRI 1055
Query: 2155 AQ---------KELEEAVTSALQQETEKSKAAKELAENK----KKIDALLDWVTS--VGS 2199
+ K++EE S L+ EK K E + K ++ + L W+
Sbjct: 1056 TKEAGSVSLRMKQVEELYHSLLELG-EKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
Query: 2200 SGGQLLTNLPGMEQLSGA--SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 2257
+ ++ +L +E L +K +N+ E L+ E + A + + Q
Sbjct: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAEEVQAVQQ 1172
Query: 2258 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQ-------QKLGELKEQYSTSLAQSEAELK 2310
Q+ + + + + +P + L + EL E++ SL Q E
Sbjct: 1173 QEVYGMMPRD-----ETDSKTASPWKSARLMVHTVATFNSIKELNERWR-SLQQLAEERS 1226
Query: 2311 QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH 2370
Q+ E+Q+F +D E + W+E + L N G ++ +L ++ H
Sbjct: 1227 QLLGSAHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQRK----------H 1275
Query: 2371 KGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN 2430
+G R + G KV + G+ + + +D E+ T L+ + LG +
Sbjct: 1276 EGFERDLAALGDKVNSL------GETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRAD 1329
Query: 2431 M---LLGQYH---QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQE 2484
LG H +F + L +W+ V SD +A D + + L E
Sbjct: 1330 QRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS---SDELAKD-------VTGAEALLE 1379
Query: 2485 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2544
EH+ ++ + E G+ H H Q L ER+ L +
Sbjct: 1380 RHQEHRTEID-ARAGTFQAFEQFGQQLLAHGHYASPEIK-----QKLDILDQERADLEKA 1433
Query: 2545 AIAQSQSVQESLESLL--QSIGEVEQNLEGKQ--VSSLSSGVIQEALATNMKLKQDIARQ 2600
+ + + + LE L + + E + ++ +++ G +++ +K +D +
Sbjct: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDK- 1492
Query: 2601 KSSLEATREMVTRFMETADSTTAA------VLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2654
++ E + AD AA + + EV R+ +L Q EK S L +
Sbjct: 1493 --AINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE- 1549
Query: 2655 LPQAEMFEHLSGKLQQFMENKSRMLASGNQPD-QDITHFFQQIQELNLEME---DQQENL 2710
+ F +++ ++ K + + + D +I Q+ Q E+ D+ +
Sbjct: 1550 SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGV 1609
Query: 2711 DTLEHLVTELSSCGFALD-----LCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLD 2765
+ + + E +C + D L D+ Q L + E + +KE K
Sbjct: 1610 IDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ--------Q 1661
Query: 2766 EFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKG 2825
F ++ F WL E E +++++ K + + +LL K L+E
Sbjct: 1662 NFNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLL----KKHQLLE------ 1704
Query: 2826 TSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLG 2885
+I+A + + K L S S+ + + + D ++++ +N +++K+
Sbjct: 1705 -------ADISAHEDRLKD---LNSQADSLMTSSAF----DTSQVKDKRDTINGRFQKIK 1750
Query: 2886 GVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN 2945
+ R+ L +R+ + ++ + W++ K+ ++ S D T + ++ + +
Sbjct: 1751 SMAASRRAKLNE-SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR---KKH 1806
Query: 2946 KAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR 3005
K AEL + P IQ V + G ++ N+ E ++ + W+ ++ AR +
Sbjct: 1807 KRLEAELAAHEPAIQGVLD--TGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQ 1864
Query: 3006 QLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEAR 3065
+LEES + F A + W+ EK ++ S D A +Q +LK+ EA
Sbjct: 1865 RLEESLEYQQ-FVANVEEEEAWINEKMTLVA-----SEDYGDTLA---AIQGLLKKHEAF 1915
Query: 3066 RQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKS 3125
+ + T D+ + ++ + S LN + S +++A +
Sbjct: 1916 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISS-------KMKGLNGKVSDLEKA---A 1965
Query: 3126 TQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQT 3185
Q + L + S ++ + V+S I + ++K T + DL + + + +T
Sbjct: 1966 AQRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-----TDDYGRDLSSVQTLLTKQET 2020
Query: 3186 LCDELSVLIGE-----QYLKDEL--KKRLETVALP------LQGLEDLAADRINRLQAAL 3232
L E LKD+L K +++ A+ ++ L A+ R + L
Sbjct: 2021 FDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLL 2080
Query: 3233 ASTQQFQQMFDELRTWLDD--------KQSQQAKNCPISA-KLERLQSQLQENEEFQKSL 3283
+ F+++ D T+ + +++ P+ LE +++ + ++ F+ SL
Sbjct: 2081 EAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2140
Query: 3284 NQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR-------QS 3336
+ + + AE + + S T + L+ W L K +R Q
Sbjct: 2141 SSAQADFNQL-AELDRQIKSFRVASNPYTWFT-MEALEETWRNLQKIIKERELELQKEQR 2198
Query: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAMLNEVEKR 3395
R ++ + Q++ H WI++ + + + ++ LES L +K E+
Sbjct: 2199 RQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAM 2258
Query: 3396 RSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA-----------VTEELQAK--T 3442
RS L+ + + + D G+ Q D + +++QA+ T
Sbjct: 2259 RSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTT 2318
Query: 3443 GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQE---VL 3499
G EE L+EF FK+ +K G + E L S +E+ E +L
Sbjct: 2319 GVTEE---ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAIL 2375
Query: 3500 QALEPQVD 3507
++P D
Sbjct: 2376 DTVDPNRD 2383
Score = 70.9 bits (172), Expect = 4e-11
Identities = 91/435 (20%), Positives = 178/435 (40%), Gaps = 37/435 (8%)
Query: 5170 EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLA 5229
E ++ + +V D++ S R+ KLE++ F DA + L W+ + + Q+A
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIA 67
Query: 5230 EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 5289
D+ +L + H+ F+ E+ +G + L +G +I + ++ +L E
Sbjct: 68 SDENYKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLME 126
Query: 5290 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 5349
L +W+ + + K +L QA K + R+ ++ +W+++ E + L D E +
Sbjct: 127 LHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVM-DWINDKEAIVTSE-ELGQDLEHV 184
Query: 5350 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW 5409
+ L +EF + VN ++ HP+ IK + A ++ +
Sbjct: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGL 243
Query: 5410 AKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQT 5469
A Q Q +L A N ++ +E ++WI+ E + D +++ V+AL+ +H+
Sbjct: 244 ALQRQGKLFGAAEVQRFNRDV-DETISWIKEKEQLMASDD---FGRDLASVQALLRKHEG 299
Query: 5470 FMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK 5529
++ + V + R L Q P LS ++ +
Sbjct: 300 LERDLAALEDKVKALCAEADR---------------------LQQSHP-----LSATQIQ 333
Query: 5530 NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSR 5589
R +L W+Q+ LA ER +LND+ L +F + V K + + S
Sbjct: 334 VKR-EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASD 392
Query: 5590 VMDFFRRIDKDQDGK 5604
V +D+ Q+ K
Sbjct: 393 VAGAEALLDRHQEHK 407
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 259 bits (661), Expect = 7e-68
Identities = 495/2577 (19%), Positives = 1012/2577 (39%), Gaps = 263/2577 (10%)
Query: 3156 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQ 3215
PE V QL + I L L EV Q D + + + L + KK E A+ +Q
Sbjct: 230 PEDVAVQLPDKKSIIMYLTSL-FEVLPQQVTIDAIREV---ETLPRKYKKECEEEAINIQ 285
Query: 3216 GLEDLAADRINRLQAALASTQ------QFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
R + T+ +Q +E+ TWL + + IS +E +
Sbjct: 286 STAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEV 345
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS-VPPGEEKRTLQNQLVELKNHWEELS 3328
+ Q +E F L H S ++ G L+ EE+ +Q Q+ L WE L
Sbjct: 346 KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
Query: 3329 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWI---EDCKAKMSELRVTLDPVQLESSLLRS 3385
++ DRQSRL D + + QK Q ++ L W+ E+ KM + D L+ L
Sbjct: 406 VESMDRQSRLHDVLMELQKKQ--LQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEH 463
Query: 3386 KAMLNEVEKRRSLLEILNSAADILI-NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGS 3444
K++ +++E + + L I+ NS E+ + D+ + + AV + +
Sbjct: 464 KSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNR 523
Query: 3445 LEEMT---QRLREFQESFKNIEKKVEGA---------KHQLEIFDALGSQACSNKNLEKL 3492
L+E+ Q L E Q K + E A K Q E+ ++ A +++E
Sbjct: 524 LQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMK 583
Query: 3493 RAQQEVLQALEPQVDYL--------------RNFTQ---GLVEDAPDGSD----ASQLLH 3531
R + L + V L TQ LV+ D S+ A L
Sbjct: 584 RQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLG 643
Query: 3532 QAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA---- 3587
+++ Q++ LE RV + ++K E + R++ + + + D + A
Sbjct: 644 MSQIPQKDLLETV-RVREQAITKKSKQELPPPPPPKKRQIHVDI-EAKKKFDAISAELLN 701
Query: 3588 -IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALN 3646
I + ++Q+ + + +K ++A E E R + L+ G + +E +
Sbjct: 702 WILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTG-QILVEQMG 760
Query: 3647 KQCGKLTERGKARQEQLELTLGRV----EDFYRKLKGLNDATTAAEEAEALQWVVGTEVE 3702
K+ G TE K E++ V ED RK++ D ++ + L+ V+ T+ E
Sbjct: 761 KE-GLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEE 819
Query: 3703 IINQQLADFKMFQK--EQVDPLQMKLQQVNGLGQGLIQSAGKDCDV--------QGLEHD 3752
+ Q D Q +L + GL I+ A C ++
Sbjct: 820 WVKHTSISESSRQSLPSLKDSCQRELTNLLGL-HPKIEMARASCSALMSQPSAPDFVQRG 878
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALL----HCGKFQDALEPLLSWLADTEELIANQKPP 3808
+ R+ + + V R L+ L H + + L+ L L D+E
Sbjct: 879 FDSFLGRYQAVQEAVEDRQQHLENELKGQPGHA--YLETLKTLKDVLNDSENKAQVSLNV 936
Query: 3809 SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ-LESLES 3867
+ V+ +QE+K L +L+++K + L E + ++ D EK+ Q + ++
Sbjct: 937 LNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVH-PDVEKLYKQEFDDVQG 995
Query: 3868 RWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ 3927
+W +L + LE+I + + F + I ++ + L + A +Q+Q
Sbjct: 996 KWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQ 1055
Query: 3928 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+ + A +IE + + +I +L S + + ++ Q + ++
Sbjct: 1056 LDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIAT 1115
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
+ + L ++ A +D E+ W+ + E++ + + L + E++
Sbjct: 1116 QKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDV 1175
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107
+ ++ V + +K+ LL + +L+ + Y + TLE+
Sbjct: 1176 LQKEVRV-KILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSC 1234
Query: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN 4167
+ + T WL +EE + ++ + + + + + + + ++R +
Sbjct: 1235 WIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRT---QIR 1291
Query: 4168 EVSRALLELVPWRAREGLDKLVSDA----NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 4223
E+ + L++ LD ++S+ N +Y+ +S + ++ +Q ++ +Q
Sbjct: 1292 ELGQTLID------GGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQM 1345
Query: 4224 ADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS--- 4280
+ E ++L R++ Q + Q +A +I H+ +++EL +
Sbjct: 1346 LQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQA---EISAHELTLEELRRNMRSQP 1402
Query: 4281 ----EIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 4336
E G Q VLQ K + +++ + L+ +VL
Sbjct: 1403 LTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVL----------- 1451
Query: 4337 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL-KELN 4395
+ +A + L +D + ++ ++ +L ++++E K ++ ++K G + ++
Sbjct: 1452 ----DGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQ 1507
Query: 4396 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 4455
+ + ++E+ + +Y + +V + L+ A + ++ + + L E
Sbjct: 1508 TDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETEL 1567
Query: 4456 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA 4515
+ + ++D IS K+ +LEK + + L +G++ L
Sbjct: 1568 VQKSTSEGLLGDLDTE---ISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPIL-- 1622
Query: 4516 KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLE 4575
+++L + W ++ E+ ++ E F ++A + T + + ++ ++E
Sbjct: 1623 ---EERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIE 1679
Query: 4576 SPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMN 4635
+Q E + + E D + ++E +R L+ A G + + V + E+N
Sbjct: 1680 KKPTS-----KQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELN 1734
Query: 4636 NAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD 4695
+E +++ K KL A + Q T + T + + + D+ +
Sbjct: 1735 RNFEKVSQHIKSA--KLLIAQEPLYQCLVTTETF-----ETGVPFSDLEKLENDIENMLK 1787
Query: 4696 QLNEMKEFKVE---VYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLG 4752
+ + E E + ++ ++E++ +GE ML + ++ ++ IR L L H N
Sbjct: 1788 FVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLL-LLHTRYNKI 1846
Query: 4753 EKIAHRQHKLEGALLALGQFQHALEELM---SWLTHTEELLDAQRPISGDPKVIEVELA- 4808
+ I +Q K+ GQ + + +L ++L + V E+ A
Sbjct: 1847 KAIPIQQRKM-------GQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAI 1899
Query: 4809 ------KHHVLKN-----DVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4857
+ LKN D L Q V +++ +++ ++G +A +R L +N W
Sbjct: 1900 YEDFSFQEDSLKNIKDQLDKLGEQIAV--IHEKQPDVILEASGPEAIQIRDTLTQLNAKW 1957
Query: 4858 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD 4917
+ + + +R+ +++ + FH ++ D +T E L + GG + + ++
Sbjct: 1958 DRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIH 2017
Query: 4918 THMELYSQLKAKEETYNQL--LDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975
EL + + + ++ L G + LS+ D GS ++ +A L Q+W + ++++
Sbjct: 2018 -QQELEVGISSHQPSFAALNRTGDGIVQKLSQAD---GSFLKEKLAGLNQRWDAIVAEVK 2073
Query: 4976 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANE 5035
+R+ +L+ ++++ L E I WLT AE ++ S L N ++E + E
Sbjct: 2074 DRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGEN-----LQELRDLTQE 2128
Query: 5036 VNAHRDQIIELDQTGNQLKFLSQKQ----DVVLIKNLLVSVQSRWEKV-------VQRSI 5084
+ H +++ L++T +L+ LS K + I L +V W K+ ++ I
Sbjct: 2129 MEVHAEKLKWLNRT--ELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECI 2186
Query: 5085 ERGRSLDDARKRAK-----------------QFHEAWK------------KLIDWLEDAE 5115
+ S+ R A Q H + +L DWL +
Sbjct: 2187 QEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLID 2246
Query: 5116 SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKL 5175
L S + D ++I +S+ K + L + P D + LK K + +
Sbjct: 2247 QMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAI 2306
Query: 5176 DNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVH 5235
L V+++WD RQ +LE+ ++ S Q+ D + + + K E +L Q
Sbjct: 2307 TEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQAR 2366
Query: 5236 GDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQELSTRW 5294
D L + D +++ +ELG G V ++L+E DDT VK + L T W
Sbjct: 2367 RD-PLTKQISD-NQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSW 2424
Query: 5295 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRF-------RGALPDDTE 5347
+ + +Q+ LE + + R + L+W+ EAE T+ AL D
Sbjct: 2425 INLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSIL 2484
Query: 5348 A---------LQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITI 5398
A +Q+ ID H + K ++ R + A+ E T ++H +
Sbjct: 2485 ARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEA---------TMLQHRLDD 2535
Query: 5399 IRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNID 5458
+ R+ ++ + + LE + + LEEL+ W+ + L + Q PI ++
Sbjct: 2536 MNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEEL--KKQMPIGGDVP 2593
Query: 5459 RVKALIAEHQTFMEEMTRKQPDV-DRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTP 5517
++ + E+ K+ V + V + +P AP E R+ K+ P
Sbjct: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPE-EPRRNLQSKTELTPEE 2652
Query: 5518 PPMPIL-------SQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-ELKE 5566
I S+ + K +N +++ WQ+ ALE+ R L A+D L+ ++KE
Sbjct: 2653 RAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKE 2709
Score = 254 bits (650), Expect = 1e-66
Identities = 499/2646 (18%), Positives = 1026/2646 (38%), Gaps = 301/2646 (11%)
Query: 2685 PDQDITHFFQQIQ-----ELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNL 2739
P + + H F + Q E L+ ED L + ++ L+S ++ Q + +
Sbjct: 207 PIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSL---FEVLPQQVTIDAI 263
Query: 2740 RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKE--L 2797
R+ T +K KE E++A + Q E + ET ++ + + + + L
Sbjct: 264 REVETLPRKYKKECEEEAINIQSTAPE-----EEHESPRAETPSTVTEVDMDLDSYQIAL 318
Query: 2798 EKQIEHLKSLLDDWASKGTL---VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSS 2854
E+ + L S D + + + VEE+ + + E +ME+TA Q GS+L +
Sbjct: 319 EEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTA--HQSSVGSVLQAGNQL 376
Query: 2855 VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQ 2914
+ G + ++ EIQ M+ +N ++E L +RQ L +L ME K+ +
Sbjct: 377 I--TQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVL--MELQKKQLQQLSA 432
Query: 2915 WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP 2974
WL EE ++ M+ ++++ E +K+ ++LE K+ + + ++
Sbjct: 433 WLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV---VIVDE 489
Query: 2975 NSQEA-------------ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 3021
NS E+ E W + RW R E+ + Q LEE +
Sbjct: 490 NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEE-----------Q 538
Query: 3022 SQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080
L+ WL EKE + + + D L+ +++ + ++ E +RQ +QL+E Q +
Sbjct: 539 CLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV- 597
Query: 3081 TGPG---DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSE 3137
G D S ++ ++ + + + Q+W L +L S+Q+ QA+ K Q +DL E
Sbjct: 598 ---GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLE 654
Query: 3138 KVRAVGQRLSVQS-----------------------------------------AISTQP 3156
VR Q ++ +S AI T
Sbjct: 655 TVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTE 714
Query: 3157 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELS---VLIGEQYLK-----DELKKRLE 3208
++++TSE++ L+ L+ E +E DEL+ ++ EQ K +E+K LE
Sbjct: 715 IKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLE 774
Query: 3209 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 3268
V+ + + D ++Q F+Q+ DEL + K+ + K+ IS +
Sbjct: 775 KVSSEWKNVSQHLEDLERKIQLQEDINAYFKQL-DELEKVIKTKE-EWVKHTSISESSRQ 832
Query: 3269 LQSQLQENEEFQKSLNQHSGSYEVI--VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEE 3326
L+++ Q+ L G + I S L+S P + +Q ++
Sbjct: 833 SLPSLKDS--CQRELTNLLGLHPKIEMARASCSALMSQPSAPD--FVQRGFDSFLGRYQA 888
Query: 3327 LSKKTADRQSRLKDCM--QKAQKYQWHVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLL 3383
+ + DRQ L++ + Q Y ++ L + D + K L V D ++E +L
Sbjct: 889 VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
Query: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI-RDEKAGINQNMDAVTEELQAKT 3442
K + +E ++ L L L + D + + + E + + + +
Sbjct: 949 EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDL 1008
Query: 3443 GSLEEMTQRLREFQESFKNIEKKVEGAKHQL-EIFDALGSQACSNKNLEKLRAQQEVLQA 3501
LEE+ LR F+ IEK ++G K L + A G A + L++ A ++
Sbjct: 1009 HLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIET 1068
Query: 3502 LEPQVDYLRNFTQGLVEDAPDG------SDASQLLHQAEVAQQEFLEVKQRVNSGCVMME 3555
+E + ++ L G + Q E +E K R++
Sbjct: 1069 IESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAA 1128
Query: 3556 NKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLD 3615
N + + + + + + + D E + + ++ EDV ++ +LK +
Sbjct: 1129 NLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDN 1188
Query: 3616 IEASEAECRHMLEEEGTLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFY 3674
I+ A+ G +L L LE C ++ RGK TL V +
Sbjct: 1189 IKLLAAKV-----PSGGQELTSELNVVLENYQLLCNRI--RGKCH------TLEEVWSCW 1235
Query: 3675 RKLKGLNDATT----AAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVN 3730
+L D T EE V+ + + +N+ L + + D Q+
Sbjct: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPAD----NRTQIR 1291
Query: 3731 GLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEP 3790
LGQ LI D D+ + +E N+R+ L+ + L++ L + L+
Sbjct: 1292 ELGQTLIDGGILD-DI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQV 1348
Query: 3791 LLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSA 3850
L L + ++ + + V QE + +Q + + T++ L+ R +S
Sbjct: 1349 LQESLGELDKQLTTYLTDRIDAFQVP---QEAQKIQAEISAHELTLEELR----RNMRSQ 1401
Query: 3851 ELADREKIT----GQLESLESRWTELLSKAAARQK--QLEDILVLAKQFHETAEPISDFL 3904
L E T Q++ L+ + E+ +K QK E ++ K+ + + L
Sbjct: 1402 PLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKR---VLDGVKAEL 1458
Query: 3905 SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQ 3964
V + K + + + T K + L + + +V +K G+ +
Sbjct: 1459 HVLDVKDVDPDVIQTHLDKCMK-------LYKTLSEVKLEVETVIKTGRHIVQKQQTDNP 1511
Query: 3965 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVF 4024
+ E++ SL+ Y+++ + L++A AR ++ + WL+ E +L
Sbjct: 1512 KGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKS 1571
Query: 4025 VKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIK 4084
+ L + + + +++ RK +++ ++ AL G E +L +E+L +
Sbjct: 1572 TSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPIL-EERLCVLN 1630
Query: 4085 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQ 4144
++ + + TL + F ++ WL + E L + PT +Q
Sbjct: 1631 AGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQA-EALLDEIEKKPTSKQ--- 1686
Query: 4145 FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 4204
++ K L E+ + L ++ V + + L+ +RE ++ +++ N ++ VS
Sbjct: 1687 -EEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVS---- 1741
Query: 4205 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID 4264
Q + I + Y+ E ET L +LE D V+K ++
Sbjct: 1742 QHIKSAKLLIAQEPLYQCLVTTE---TFETGVPFSDLE--KLENDIENMLKFVEK--HLE 1794
Query: 4265 IIRHKDSMDELFSHRSEIFGTCGEE--QKTVLQEKTESL------------------IQQ 4304
+ MDE + E+ GEE + + K E + IQQ
Sbjct: 1795 SSDEDEKMDEESAQIEEVLQR-GEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQ 1853
Query: 4305 YEAISLLNSERYARLERAQVL-VNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 4363
+ L + R + L ++ +N+ +++ + A + + L+
Sbjct: 1854 RKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNI 1913
Query: 4364 QEEMRQLRESIAE-HKPHIDKLLKI-GPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVR 4421
++++ +L E IA H+ D +L+ GP+ ++ + + K+ + MY+
Sbjct: 1914 KDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIR-DTLTQLNAKWDRINRMYS------- 1965
Query: 4422 QRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSA 4481
R D A+ + Q FH + + + + + L + P + + +
Sbjct: 1966 DRKGCFDRAMEEWRQ---FHCDLNDLTQWITE-AEELLVDTCAPGGSLDLEKARIHQQEL 2021
Query: 4482 TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREI 4541
V + QPSF AL R G+ ++ + AD +++KL + W+ I A ++R+
Sbjct: 2022 EVGISSHQPSFAALNRTGDGIVQKLSQADGSF----LKEKLAGLNQRWDAIVAEVKDRQP 2077
Query: 4542 KFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSI--IKQQVEAAETIKEETD 4599
+ + K+ + + ++ + + + + + ++ ++ + E E+
Sbjct: 2078 RLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLK 2137
Query: 4600 GLHE-ELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNK----TWKERLEKLED 4654
L+ ELE + L E+ ++ +S+ +N W + + T KE +++
Sbjct: 2138 WLNRTELEMLSDKSLSL------PERDKISESLRTVNMTWNKICREVPTTLKECIQEPSS 2191
Query: 4655 AMQAAVQYQDTLQAMF---------------------DWLDNTVIKLC------------ 4681
Q + +Q + LD T+ +L
Sbjct: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251
Query: 4682 TMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPL 4741
+ VG D+ + ++ MK K ++ Q+ +++ + + + KA+ R I E L
Sbjct: 2252 NIVTVG-DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKL 2310
Query: 4742 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4801
+K+ W+ + RQ +LE ++ Q+ EE + E L + DP
Sbjct: 2311 ERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDP- 2369
Query: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861
+ +++ + +L ++ V + +LLE DD +++ E + W ++
Sbjct: 2370 -LTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLK 2428
Query: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQ 4915
Q +R+ L++ + Q ++E+FL + E+ ++ AS L ++ ARE
Sbjct: 2429 QSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAREL 2488
Query: 4916 LDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975
++ +++ A + + + + M+ + +S + + + + Q+W+ + +K
Sbjct: 2489 KQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSA 2548
Query: 4976 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANE 5035
++ LE + SL+E I WL + ++ L P + + Q + K E
Sbjct: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
Query: 5036 VNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA-R 5094
+ ++ +Q + Q + + ++QS+ E + ER + + A R
Sbjct: 2609 LKEKEYSVL---NAVDQARVFLADQPIEAPEEPRRNLQSKTELTPE---ERAQKIAKAMR 2662
Query: 5095 KRAKQFHEAWKKL----IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQP 5150
K++ + E W+ L +W + + L+ ++ D + + KE + G +P
Sbjct: 2663 KQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADM---KEAESVRNGWKP 2719
Query: 5151 VYDTTI 5156
V D I
Sbjct: 2720 VGDLLI 2725
Score = 231 bits (590), Expect = 1e-59
Identities = 478/2686 (17%), Positives = 1048/2686 (39%), Gaps = 312/2686 (11%)
Query: 2439 FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQK 2498
+Q + + + W+ + E ++ D ++ D +++Q AT + EL HQ V + +
Sbjct: 314 YQIALEEVLTWLLSAEDTFQE--QDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQ 371
Query: 2499 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES 2558
++ + +QE + + +++L +R S L + + Q Q L+
Sbjct: 372 AGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQ--LQQ 429
Query: 2559 LLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFME 2616
L + E+ ++ + L V +Q+ L + L+ D+ ++ + + MV E
Sbjct: 430 LSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDE 489
Query: 2617 TADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKL-LPQAEMFEH---LSGKLQQFM 2672
+ + A+L+ +L ++ +R+ +C +E+ + L+++ + E+ E L L +
Sbjct: 490 NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549
Query: 2673 ENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQH 2732
E +++ S + ++++ +++ L +ME +++ LD L + ++ G LD +
Sbjct: 550 EALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDV---GQLLDNSKA 606
Query: 2733 QDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM 2792
++ + ++ T+ ++ +R +D+S+ Q + + QK L ET T
Sbjct: 607 SKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKK 666
Query: 2793 SAKELEKQIEHLKSLLD-DWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSV 2851
S +EL K + D +K ++ + L N I++
Sbjct: 667 SKQELPPPPPPKKRQIHVDIEAK----KKFDAISAELLNWILK----------------- 705
Query: 2852 GSSVGSVNGYHTCKDLTEIQ--CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909
+ T TEI+ M D + +KL + E++E + R +E+++
Sbjct: 706 ---------WKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIP----RADELNQTG 752
Query: 2910 NSVLQWLESK----EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA 2965
+++ + + EE+ ++ +SS K + LE KIQ ++
Sbjct: 753 QILVEQMGKEGLPTEEIKNVLEKVSSEWKNVS------------QHLEDLERKIQLQEDI 800
Query: 2966 LAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLR 3025
A + E E K +EE W + T ++ + ++ L +C Q + L
Sbjct: 801 NA----YFKQLDELEKVIKTKEE----WVKHTSISESSRQSLPSLKD--SC-QRELTNLL 849
Query: 3026 PWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG-PG 3084
+ E+ L P+ + ++ L ++A ++ E + + L G PG
Sbjct: 850 GLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPG 909
Query: 3085 DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144
L T + K++ L D N ++ +L DL++ +A+ +
Sbjct: 910 HAYLETLKTLKDV---------LNDSENKAQVSLN-----------VLNDLAKVEKALQE 949
Query: 3145 RLSVQSAISTQPEAVKQQLEETS----EIRSDLEQL-DHEVKEAQTLCDELSVLIGEQYL 3199
+ ++ + Q A+ + EET + D+E+L E + Q ++L VL+ +
Sbjct: 950 KKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDL- 1008
Query: 3200 KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKN 3259
LE +AL L+ E A + ++ D ++ +L +Q+ Q +
Sbjct: 1009 -----HLLEEIALTLRAFE--------------ADSTVIEKWMDGVKDFLMKQQAAQGDD 1049
Query: 3260 CPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 3319
+ +L++ + + E E + SL + E E+ L S P K +Q +L +
Sbjct: 1050 AGLQRQLDQCSAFVNEIETIESSLKN--------MKEIETNLRSGPVAGIKTWVQTRLGD 1101
Query: 3320 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-DPVQL 3378
+ E+LSK+ A ++SRL + +KA + + ++ W+ + + E P +L
Sbjct: 1102 YQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEEL 1161
Query: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL 3438
ES++ K +V ++ ++IL +L + + E + +N + +
Sbjct: 1162 ESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRI 1221
Query: 3439 QAKTGSLEEMTQ------RLREFQESFKN-IEKKVEGAKHQLEIFDALGSQACSNKNLEK 3491
+ K +LEE+ + + ++ N +E++++ + E DA+ E
Sbjct: 1222 RGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVN---------EA 1272
Query: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQA-EVAQQEFLEVKQRVNSG 3550
L + + VL+ +R Q L+ DG ++ + E + ++ S
Sbjct: 1273 LESLESVLRHPADNRTQIRELGQTLI----DGGILDDIISEKLEAFNSRYEDLSHLAESK 1328
Query: 3551 CVMMENKLEGIGQFHCRVREMFSQLADLDDEL-----DGMGA--IGRDTDSLQSQIEDVR 3603
+ +E +L+ + + ++ + L +LD +L D + A + ++ +Q++I
Sbjct: 1329 QISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHE 1388
Query: 3604 LFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQL 3663
L L + L+ ++ + G + L+R+L ++ + + Q L
Sbjct: 1389 LTLEE---LRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRML 1445
Query: 3664 ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQ 3723
D R L G+ E L V + ++I L D M + + ++
Sbjct: 1446 --------DCKRVLDGVK------AELHVLD-VKDVDPDVIQTHL-DKCMKLYKTLSEVK 1489
Query: 3724 MKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGK 3783
++++ V G+ ++Q D + +G++ + + +N L +V + L+ A K
Sbjct: 1490 LEVETVIKTGRHIVQKQQTD-NPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARK 1548
Query: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
+ L WL+ TE + + + +I K + + L+ RKA ++ +
Sbjct: 1549 MKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESS 1608
Query: 3844 GRIAQSAE-----LADREKITGQLESLESRWTE-LLSKAAARQKQLEDILVLAKQFHETA 3897
+ E L +R + S WTE + Q QLE F
Sbjct: 1609 AALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEI-------FDGNV 1661
Query: 3898 EPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSS 3957
IS +L E L E T Q++I+ K L ++++ V L +
Sbjct: 1662 AHISTWLYQAEALLDEIEKKPTSK---QEEIV--KRLVSELDDANLQVENVRDQALILMN 1716
Query: 3958 LTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
+ + ++ K+ L + ++ L+ Q L + E +++E
Sbjct: 1717 ARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLE 1776
Query: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGE------ 4071
KL + K H + +D +E++ +++ ++ G+ +L Q +
Sbjct: 1777 -KLENDIENMLKFVEKHLESSDE---DEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKI 1832
Query: 4072 --EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ--LATKFQSTYEELTGWLREVEE 4127
++LL+ + + IK I + K + R L T + ++ + +VE
Sbjct: 1833 RLQLLLLHTRYNKIKA----IPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVEL 1888
Query: 4128 ELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR-ALLELVPWRAREGLD 4186
L + E + K +K ++ + + ++E +LE A + D
Sbjct: 1889 SLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRD 1948
Query: 4187 KLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRL 4246
L + N ++ ++ R D A++ +Q+ + W+ E + L+
Sbjct: 1949 TL-TQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGG 2007
Query: 4247 EQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYE 4306
D A++ Q+ + I H+ S L I + + L+EK L Q+++
Sbjct: 2008 SLDLEKARIH-QQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWD 2066
Query: 4307 AISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366
AI +R RL+ V ++ +E+ W+ + + + + +L + +E
Sbjct: 2067 AIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-----ELGENLQE 2121
Query: 4367 MRQLRESIAEHKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQR 4423
+R L + + H + L + ++ K L+ E + + E + + +I EV
Sbjct: 2122 LRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREV--- 2178
Query: 4424 ALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL--------IPAEVDK----- 4470
L E + + + +++ P ++ + +SS +P IPA++DK
Sbjct: 2179 PTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITEL 2238
Query: 4471 -----------------------IRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
I + +S K +LE+ P + + + L ++
Sbjct: 2239 ADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKAS 2298
Query: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567
+D A I +KL+++ W+ + E R+ + D++ + ++ ++
Sbjct: 2299 SSDMRTA---ITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKY 2355
Query: 4568 QDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEV 4627
+ ++ L+ DP + KQ + ++E G + F +L L+ G + V
Sbjct: 2356 EARLYILQQARRDP-LTKQISDNQILLQELGPGDGIVMAFDNVL-QKLLEEYGSDDTRNV 2413
Query: 4628 RKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG 4687
+++ + + +W NL ++ +R LE + + L+ W+ + +
Sbjct: 2414 KETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDAS 2473
Query: 4688 TDLNTVKDQL------NEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPL 4741
N ++D + +M++ + E+ + ++ + M+K + + +++ L
Sbjct: 2474 HRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRL 2533
Query: 4742 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4801
++ W +L K A + LE + + +LEEL+ WL +E L Q PI GD
Sbjct: 2534 DDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVP 2593
Query: 4802 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELL-----------------------ESS 4838
++++ L+ ++ + +V L E
Sbjct: 2594 ALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEER 2653
Query: 4839 AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQ 4898
A A ++R + + + WES+ T ++Q+ L++ + ++D ++ ES
Sbjct: 2654 AQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESV 2713
Query: 4899 LSASKPTGGL----PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4954
+ KP G L + E++ E + + K +T N L + LS D
Sbjct: 2714 RNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-----LSPLDLHPSL 2768
Query: 4955 KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 5000
K + + L +W ++ +++R +L+EA +F S Q F++
Sbjct: 2769 KMSRQLDDLNMRWKLLQVSVDDRLKQLQEA---HRDFGPSSQHFLS 2811
Score = 226 bits (577), Expect = 4e-58
Identities = 438/2532 (17%), Positives = 1014/2532 (40%), Gaps = 281/2532 (11%)
Query: 3014 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 3073
L +Q A ++ WL+ E +S D + Q + + E A + +
Sbjct: 311 LDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVL 370
Query: 3074 EAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 3133
+A ++T ++Q+++ +N +W L + R S++ +++ + Q LQ
Sbjct: 371 QAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQ--LQ 428
Query: 3134 DLSEKVRAVGQRLSVQSA--ISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQ---TLCD 3188
LS + +R+ + +++++ LEE ++SDLE +V + D
Sbjct: 429 QLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVD 488
Query: 3189 ELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 3248
E S L+D+L+K E + E+ R NRLQ Q+ + L+ W
Sbjct: 489 ENSGESATAILEDQLQKLGERWTAVCRWTEE----RWNRLQEINILWQELLEEQCLLKAW 544
Query: 3249 LDDKQSQQAK--------NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 3300
L +K+ K +S + RL ++ E +++L+Q S E+ G+ +
Sbjct: 545 LTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLS---EI----GQDV 597
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWI- 3359
+ + + + + EL W+ L ++ D +++ + K Q +DL+ +
Sbjct: 598 GQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVR 657
Query: 3360 --EDCKAKMSELRVTLDP---------------------VQLESSLLRSKAMLNEVEKRR 3396
E K S+ + P +L + +L+ K + E +
Sbjct: 658 VREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKE 717
Query: 3397 SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ 3456
+ S + + E ++ +NQ + E++ + EE+ L +
Sbjct: 718 YMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVS 777
Query: 3457 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3516
+KN+ + +E + ++++ + + N ++L ++V++ E V + + ++
Sbjct: 778 SEWKNVSQHLEDLERKIQLQEDI------NAYFKQLDELEKVIKTKEEWVKHT-SISESS 830
Query: 3517 VEDAPDGSDASQL-------LH-QAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV 3568
+ P D+ Q LH + E+A+ + + ++ + +G++
Sbjct: 831 RQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQ 890
Query: 3569 REMFSQLADLDDELDGMG--AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHM 3626
+ + L++EL G A +L+ + D NK V L++ A+
Sbjct: 891 EAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSE---NKAQV-SLNVLNDLAKVEKA 946
Query: 3627 LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGR--------VEDFYRKLK 3678
L+E+ TLD + L+ + AL+K L E KA ++ + + + V+ + KLK
Sbjct: 947 LQEKKTLDEI-LENQKPALHK----LAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLK 1001
Query: 3679 GLNDA----------TTAAEEAEAL---QWVVGTEVEIINQQLA--DFKMFQKEQVDPLQ 3723
L T A EA++ +W+ G + ++ QQ A D Q+ Q+D
Sbjct: 1002 VLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQR-QLDQCS 1060
Query: 3724 MKLQQVNGLGQGL-----IQSAGKDCDVQGLEHDME----EINARWNTLNKKVAQRIAQL 3774
+ ++ + L I++ + V G++ ++ + + L+K++A + ++L
Sbjct: 1061 AFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
Query: 3775 QEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKA 3834
E+ + L + W+ EE + + +++ ++E K + + ++
Sbjct: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEV 1180
Query: 3835 TVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFH 3894
V +L+ +A +E +T +L + + L ++ + LE++ +
Sbjct: 1181 RVKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELL 1239
Query: 3895 ETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQS 3954
+ + +L+ E+++ ++E + +T + + + ++LE + + A + Q ++GQ+
Sbjct: 1240 HYLDLETTWLNTLEERMKSTEVLPEKTDAVNEAL---ESLESVLRHPADNRTQIRELGQT 1296
Query: 3955 LSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR-----------LFG 4003
L + ++SEK+++ +RY ++ K L++ L R G
Sbjct: 1297 L--IDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLG 1354
Query: 4004 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 4063
E + ++ +L D++ + V Q + A L L E R+ Q + + ++
Sbjct: 1355 ELDKQLTTYLT---DRIDAFQVPQEAQKIQAEISAHELTLEEL---RRNMRSQPLTSPES 1408
Query: 4064 LLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLR 4123
+ G ++ ++Q KL + T++ Q Q F+ + L
Sbjct: 1409 RTARG-GSQMDVLQRKLREVSTKF---------------QLFQKPANFEQRMLDCKRVLD 1452
Query: 4124 EVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE 4183
V+ EL + + I + +L K + E +L ++TV + R +++ +
Sbjct: 1453 GVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPK 1512
Query: 4184 GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGP 4243
G+D+ ++ Y + + + +++ A Q +++ ++ A + W++ T+ +L+
Sbjct: 1513 GMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKST 1572
Query: 4244 IRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQ 4303
++ K D+ + K ++ + + S E + +L+E+ L
Sbjct: 1573 SEGLLGDLDTEISWAKNVLKDLEKRKADLNTI-TESSAALQNLIEGSEPILEERLCVLNA 1631
Query: 4304 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQ 4363
+ + + L Q + F +S W+ + AL+ + I+ + +Q
Sbjct: 1632 GWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDE-----IEKKPTSKQ 1686
Query: 4364 QEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG-EMVEEKYQKAENMYAQIKEEVRQ 4422
+E +++L + + ++ + L E+VE K + + ++ + ++
Sbjct: 1687 EEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKS 1746
Query: 4423 RALAL-DEAVSQSTQITEFHDKIEPM--LETLENLSSRLRMPPLIPAEVDKIRECISDNK 4479
L + E + Q TE + P LE LEN +++ + + + +
Sbjct: 1747 AKLLIAQEPLYQCLVTTETFETGVPFSDLEKLEN-------------DIENMLKFVEKHL 1793
Query: 4480 SATVELEKLQPS---FEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKA-R 4535
++ E EK+ E + +RGEE++ + +D ++I+ +L + + IKA
Sbjct: 1794 ESSDEDEKMDEESAQIEEVLQRGEEMLHQPM---EDNKKEKIRLQLLLLHTRYNKIKAIP 1850
Query: 4536 AEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH-DLESPGIDPSIIKQ---QVEAA 4591
++R++ L + D + I D V L P ++ +I + Q ++
Sbjct: 1851 IQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSL 1910
Query: 4592 ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEK 4651
+ IK++ D L E++ I D+I E ++R ++ ++N W+ +N+ + +R
Sbjct: 1911 KNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGC 1970
Query: 4652 LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4711
+ AM+ Q+ L + W+ L G L+ K ++++ +E +V + Q
Sbjct: 1971 FDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQ-QELEVGISSHQ 2029
Query: 4712 IEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771
LN G+ +++K + + D ++E L L W+ + ++ RQ +L+G + +
Sbjct: 2030 PSFAALNRTGDGIVQKLS-QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMK 2088
Query: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
++H L+E++ WLT E + + + L + L ++ H ++ +N+
Sbjct: 2089 YRHQLDEIICWLTKAEHAMQKRSTTE-----LGENLQELRDLTQEMEVHAEKLKWLNRTE 2143
Query: 4832 NELL--ESSAGDDASSLRSRLEAMNQCWESVLQKT----EEREQQLQSTLQQAQGFHSEI 4885
E+L +S + + + L +N W + ++ +E Q+ S Q H +
Sbjct: 2144 LEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNV 2203
Query: 4886 EDFLLELTRMESQLSASKPT-----GGLPETAREQLDTHMELYSQLKAK------EETYN 4934
+ +L + + + + + + L +T E D + + LK+ E N
Sbjct: 2204 QKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEIN 2263
Query: 4935 QLLDKGRL---------------MLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSK 4973
+ + + ++ L+++ S ++ A+ E+ +W
Sbjct: 2264 KTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHG 2323
Query: 4974 MEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA 5033
+E R+ +LE+ + + ++ + +E + E L I + + QI ++++
Sbjct: 2324 VELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILL 2381
Query: 5034 NEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDA 5093
E+ ++ D +L D +K +++ W + Q +R +L+
Sbjct: 2382 QELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAE 2441
Query: 5094 RKRAKQFHEAWKKLIDWLEDAE---------SHLDSEL-------EISNDPDKIKLQLSK 5137
+ + + + W+++AE SH ++ L E+ I+ ++
Sbjct: 2442 WRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDA 2501
Query: 5138 HKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ 5197
H + K++ G + + +AL E++ L + L ++ +W+ + KS +
Sbjct: 2502 HNDIFKSIDGNRQ------KMVKALGNS----EEATMLQHRLDDMNQRWNDLKAKSASIR 2551
Query: 5198 HKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGK 5257
LE + + + +L+ L+ WL + +L + P+ GD+ + D K ++EL +
Sbjct: 2552 AHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKE 2611
Query: 5258 RTGTVQVLKRSGRELI------------------------ENSRDDTTWVKGQLQELSTR 5293
+ +V R + E ++ ++ Q E+ +
Sbjct: 2612 KEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEK 2671
Query: 5294 WDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLI 5353
W+++ ++ + Q ++++AL++ + + L + EAE G P + SL
Sbjct: 2672 WESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVR--NGWKPVGDLLIDSLQ 2729
Query: 5354 DTHKEFMKKVEE 5365
D ++ M EE
Sbjct: 2730 DHIEKIMAFREE 2741
Score = 181 bits (460), Expect = 1e-44
Identities = 497/2673 (18%), Positives = 1055/2673 (39%), Gaps = 408/2673 (15%)
Query: 1964 QQYEDLKQPMAERKAQLDAL-AFDIQFFISEHAQDLSPQQNRQMLR---LLNELQRSFQD 2019
Q+ +D+ + E K Q AF ++ + + Q Q++ L +E + Q+
Sbjct: 333 QEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQE 392
Query: 2020 ILEQTAAQVDALQGHLQQMEQEA----LVKTLQKQQNTCHQQLEDLCSWVGQAERALAGH 2075
+ A+ +AL+ ++ M++++ ++ LQK+Q L+ L +W+ E +
Sbjct: 393 QMTLLNARWEALR--VESMDRQSRLHDVLMELQKKQ------LQQLSAWLTLTEERIQKM 444
Query: 2076 QGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSFATVVKDIEG-----FMEENQT 2124
+ D+ +LQK + K LQ D++ N T +V + G +E+
Sbjct: 445 ETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQ 504
Query: 2125 KLSPRELTALR------EKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAK 2178
KL R R +L + ++ L EE + + L E + + +T K K
Sbjct: 505 KLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQK 564
Query: 2179 ELAENKKKIDAL----------LDWVTSVGSSGGQLLTNLPGMEQLSGAS---------- 2218
EL+ + +++ L LD ++ +G GQLL N ++++ S
Sbjct: 565 ELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSL 624
Query: 2219 ---LEKGALDTTDGY--MGVNQAPEKLDKQCEMMKARHQELLSQQQNFI---LATQSAQA 2270
LE + T +G++Q P+K E ++ R Q + + + + + Q
Sbjct: 625 VQRLEDSSNQVTQAVAKLGMSQIPQK--DLLETVRVREQAITKKSKQELPPPPPPKKRQI 682
Query: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQD--ELQKFLQD-HK 2327
+D L + + K T+ E+K+ +QD E++K L+ K
Sbjct: 683 HVDIEAKKKFDAISAELLNWILKWKTAIQTT------EIKEYMKMQDTSEMKKKLKALEK 736
Query: 2328 EFESWLERSEK-------ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDL-RFVTI 2379
E + R+++ +E M K G E + ++L++ S ++V H DL R + +
Sbjct: 737 EQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQL 796
Query: 2380 SG------------QKVLDMENSFKEGKEPSEIGNLVKDKLKDATER----YTALHSKCT 2423
+KV+ + + + SE LKD+ +R LH K
Sbjct: 797 QEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIE 856
Query: 2424 RLGSHLNMLLGQYHQ---FQNSADSLQAWMQACEANVE---KLLSDTVASDPGVLQEQLA 2477
+ + L+ Q Q DS QA + VE + L + + PG L
Sbjct: 857 MARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPG--HAYLE 914
Query: 2478 TTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE--TTDSILSHFQSLSYSL 2535
T K L++ L + + + V D+ ++E + +QE T D IL + + + L
Sbjct: 915 TLKTLKDVLNDSENKAQVSLNVLNDLAKVE-------KALQEKKTLDEILENQKPALHKL 967
Query: 2536 AERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQ 2595
AE + L+K +V +E L + + +++GK ++ ++ ++ L +
Sbjct: 968 AEETKALEK------NVHPDVEKLYK---QEFDDVQGKW------NKLKVLVSKDLHLLE 1012
Query: 2596 DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2655
+IA + EA ++ ++M D +++ + A Q ++ L++ L
Sbjct: 1013 EIALTLRAFEADSTVIEKWM---DGVKDFLMKQQAA-------------QGDDAGLQRQL 1056
Query: 2656 PQAEMFEHLSGKLQQFMENKSRM---LASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2712
Q F + ++ ++N + L SG P I + Q + D Q L+
Sbjct: 1057 DQCSAFVNEIETIESSLKNMKEIETNLRSG--PVAGIKTWVQ------TRLGDYQTQLEK 1108
Query: 2713 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR 2772
L + S L + Q++ NL+KD E+Q+ + + E++ L R
Sbjct: 1109 LSKEIATQKS-----RLSESQEKAANLKKDLAEMQEWMTQAEEE------------YLER 1151
Query: 2773 TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLI 2832
F+ S +ELE +E +K +D L +E+ K L++ I
Sbjct: 1152 DFE---------------YKSPEELESAVEEMKRAKED-----VLQKEVRVK--ILKDNI 1189
Query: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2892
+ A +PS G + S E+ + + L ++ G H +
Sbjct: 1190 KLLAAK---------VPSGGQELTS-----------ELNVVLENYQLLCNRIRGKCHTLE 1229
Query: 2893 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAEL 2952
E + + + E WL + EE +KS + + P KT+ V ES ++ L
Sbjct: 1230 EVWSCWIELLHYLDLETT----WLNTLEERMKSTEVL--PEKTDAVNEALESLESVLRHP 1283
Query: 2953 EQNSPKIQKVKEAL--AGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEES 3010
N +I+++ + L G+L + + E NSR+E + + ++Q LE+
Sbjct: 1284 ADNRTQIRELGQTLIDGGILDDIISEK--------LEAFNSRYEDLSHLAESKQISLEKQ 1335
Query: 3011 ASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE 3070
L L+ L E + + ID + + Q++Q + E ++
Sbjct: 1336 LQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELR 1395
Query: 3071 QLNEAAQGILTGPGDVSLSTSQ---VQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQ 3127
+ N +Q + + + SQ +Q++L+ ++ K+ Q K
Sbjct: 1396 R-NMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKF---------------QLFQKPAN 1439
Query: 3128 YQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC 3187
+++ + D + V L V P+ ++ L++ ++ L ++ EV +T+
Sbjct: 1440 FEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEV---ETVI 1496
Query: 3188 DELSVLIGEQYLKDE--LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDEL 3245
++ +Q + + ++L ++ + L + L+ A ++ ++ L
Sbjct: 1497 KTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASL 1556
Query: 3246 RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVP 3305
WL +++ + L L +++ + K L + I E + L ++
Sbjct: 1557 SEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTI-TESSAALQNLI 1615
Query: 3306 PGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAK 3365
G E L+ +L L W + T D + L + + + + +V + W+ +A
Sbjct: 1616 EGSEP-ILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEAL 1674
Query: 3366 MSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINS-SEADEDGIRDEK 3424
+ E + P + ++ K +++E++ +E + A IL+N+ + + + +
Sbjct: 1675 LDE--IEKKPTSKQEEIV--KRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKL 1730
Query: 3425 AGINQNMDAVTEELQ-AKTGSLEE------MTQRLREFQESFKNIEKKVEGAKHQLEIFD 3477
A +N+N + V++ ++ AK +E +T E F ++EK ++ L+ +
Sbjct: 1731 AELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVE 1790
Query: 3478 ALGSQACSNKNLEKLRAQ-QEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3536
+ ++ +++ AQ +EVLQ E + Q + ++ + LL
Sbjct: 1791 KHLESSDEDEKMDEESAQIEEVLQRGEEMLH------QPMEDNKKEKIRLQLLLLHTRYN 1844
Query: 3537 QQEFLEVKQRVNSGCVMMENKLEGI------GQFHCRVREMFSQLADLDDEL---DGMGA 3587
+ + + ++QR M GI + + ++ + D++ L + A
Sbjct: 1845 KIKAIPIQQR------KMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTA 1898
Query: 3588 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNK 3647
I D + +++++ L+K+ I + + +LE G + + ++ L LN
Sbjct: 1899 IYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDV--ILEASGP-EAIQIRDTLTQLNA 1955
Query: 3648 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3707
+ ++ R+ + + F+ L L T AEE G +++ +
Sbjct: 1956 KWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKAR 2015
Query: 3708 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3767
+ ++ + + Q +N G G++Q + D L+ + +N RW+ + +V
Sbjct: 2016 IHQQEL--EVGISSHQPSFAALNRTGDGIVQKLSQ-ADGSFLKEKLAGLNQRWDAIVAEV 2072
Query: 3768 AQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQR 3827
R +L+ K++ L+ ++ WL E A QK + E + +QE + L +
Sbjct: 2073 KDRQPRLKGESKQVMKYRHQLDEIICWLTKAEH--AMQKRSTTE---LGENLQELRDLTQ 2127
Query: 3828 LLDDRKATVDMLQAEGGRIA--QSAELADREKITGQLESLESRWTELL------------ 3873
++ + L + +S L +R+KI+ L ++ W ++
Sbjct: 2128 EMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQ 2187
Query: 3874 -------SKAAARQKQLEDILV-----LAKQFHETAE------------PISDFLSVTEK 3909
++ AA + +LV + Q H T+E ++D+L + ++
Sbjct: 2188 EPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQ 2247
Query: 3910 KLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLS 3968
L ++ +I + + R K + D+E + + Q+L + S ++ + ++
Sbjct: 2248 MLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAIT 2307
Query: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
EK++ ++ ++ Q + L+ + ++ + + E + + E +L ++
Sbjct: 2308 EKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARL--YILQQA 2365
Query: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNG-QALLKQTTGEEVLLIQEKLDGIKTRY 4087
++D L +Q +D+ L +E+ + A N Q LL++ ++ ++E + +KT +
Sbjct: 2366 RRDPLTKQISDNQILLQEL-GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSW 2424
Query: 4088 ADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQ 4147
++ + + LE + + E W++E E + S E Q
Sbjct: 2425 INLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHR-ENALQDSI 2483
Query: 4148 RQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANE----QYKLVSDTI 4203
+ELK+++ + + +D N++ +++ R+ + K + ++ E Q++L D +
Sbjct: 2484 LARELKQQMQDIQAEIDAHNDIFKSI-----DGNRQKMVKALGNSEEATMLQHRL--DDM 2536
Query: 4204 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI 4263
QR +++ A + + +A+ + R LM+L + + +L+ Q
Sbjct: 2537 NQRWNDLKAKSASIRAHLEAS------AEKWNRLLMSLEELIKWLNMKDEELKKQMPIGG 2590
Query: 4264 DIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQ 4323
D+ + D + R E L+EK S+LN+ AR+ A
Sbjct: 2591 DVPALQLQYDHCKALRRE------------LKEK---------EYSVLNAVDQARVFLAD 2629
Query: 4324 VLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDK 4383
+ E L E T AQ + A +R+Q E+++ ES+ + K
Sbjct: 2630 QPIEAPEEPRRNLQSKTELTPEERAQKIAKA-----MRKQSSEVKEKWESLNAVTSNWQK 2684
Query: 4384 LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQR-------ALALDEAVSQSTQ 4436
++ L++L +G M +++ A +KE R L +D +
Sbjct: 2685 --QVDKALEKLRDLQGAM--------DDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEK 2734
Query: 4437 ITEFHDKIEPM---LETLENLSSRLRMPPLIPA 4466
I F ++I P+ ++T+ +LSS+L L P+
Sbjct: 2735 IMAFREEIAPINFKVKTVNDLSSQLSPLDLHPS 2767
Score = 171 bits (432), Expect = 3e-41
Identities = 412/2311 (17%), Positives = 891/2311 (38%), Gaps = 287/2311 (12%)
Query: 1808 EKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQ 1867
++L ++L+L ++ + PL+ ++ LQ LL + K L+ +L+ V+ V
Sbjct: 428 QQLSAWLTLTEE-RIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVI 486
Query: 1868 IIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQL 1927
+ + + A L L+K + + WN +++ +L Q
Sbjct: 487 VDENSGESATAILEDQLQKLGERWTAVCRWTEERWN----------RLQEINILWQELLE 536
Query: 1928 EGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA--- 1984
E L L+AW+ K LN +++ D L++ +++ LK+ M ++ LD L+
Sbjct: 537 EQCL--LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIG 594
Query: 1985 FDI-QFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEAL 2043
D+ Q + A + ++ + + L + +D Q V L + Q+ Q+ L
Sbjct: 595 QDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKL--GMSQIPQKDL 652
Query: 2044 VKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQN 2103
++T++ ++ ++ + Q + R D+ A +K + +L + I
Sbjct: 653 LETVRVREQAITKKSK-------QELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILK 705
Query: 2104 RATSFATVVKDIEGFMEENQTKLSPRELTAL----REKLHQA------------------ 2141
T+ T +I+ +M+ T ++L AL RE++ +A
Sbjct: 706 WKTAIQTT--EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEG 763
Query: 2142 ------KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWV- 2194
K E + E + + LE+ + +Q + + + K+L E +K I +WV
Sbjct: 764 LPTEEIKNVLEKVSSEWKNVSQHLED-LERKIQLQEDINAYFKQLDELEKVIKTKEEWVK 822
Query: 2195 -TSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE 2253
TS+ S Q L +L Q +L +G L + EM +A
Sbjct: 823 HTSISESSRQSLPSLKDSCQRELTNL-----------LG-------LHPKIEMARASCSA 864
Query: 2254 LLSQQQNFILATQSAQAFLDQHG--HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ 2311
L+SQ + +FL ++ + QQ L+ ELK Q A L+
Sbjct: 865 LMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLE---NELKGQ------PGHAYLET 915
Query: 2312 VQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 2371
++TL+D L D + +L + K +TL +L+ Q HK
Sbjct: 916 LKTLKD----VLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQ-----KPALHK 966
Query: 2372 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNM 2431
L E E ++ L K + D ++ L ++ L
Sbjct: 967 -------------LAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEE 1013
Query: 2432 LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQV 2491
+ F+ + ++ WM + + K D LQ QL E+ +
Sbjct: 1014 IALTLRAFEADSTVIEKWMDGVKDFLMK--QQAAQGDDAGLQRQLDQCSAFVNEIETIES 1071
Query: 2492 PVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS 2551
++ ++++ ++ G A VQ + + LS +A + S L ++ ++ +
Sbjct: 1072 SLKNMKEIETNLR--SGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAAN 1129
Query: 2552 VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV 2611
+++ L + + + + E+ + S ++ A+ + K+D+ +++ ++ ++ +
Sbjct: 1130 LKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNI 1189
Query: 2612 TRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQ 2670
+ + + L +L V + ++ LC + + K +L+++ E+ +L +
Sbjct: 1190 -KLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTW 1248
Query: 2671 FMENKSRMLASGNQPDQ-DITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2729
+ RM ++ P++ D + + ++ L + +N + L L G D+
Sbjct: 1249 LNTLEERMKSTEVLPEKTDAVN--EALESLESVLRHPADNRTQIRELGQTLIDGGILDDI 1306
Query: 2730 CQHQDRVQNLR-KDFTELQKT-----------VKEREKDASSCQEQLDEFRKLVRTF--- 2774
+ N R +D + L ++ ++E ++ QE L E K + T+
Sbjct: 1307 ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTD 1366
Query: 2775 ------------------------QKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDD 2810
+ L+ S P T Q++ L+ L +
Sbjct: 1367 RIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLRE 1426
Query: 2811 WASKGTLVEE--------INCK----GTSLENLIMEI---------TAPDSQGKTGSILP 2849
++K L ++ ++CK G E ++++ T D K L
Sbjct: 1427 VSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLS 1486
Query: 2850 SVGSSVGSV--NGYHTC-KDLTE----IQCDMSDVNLKYEKLGGVLHERQESLQAILNRM 2902
V V +V G H K T+ + ++ + + Y LG + E ++ L+
Sbjct: 1487 EVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLA 1546
Query: 2903 EEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKV 2962
++ KEA S+ +WL + E L + +S + + K L +LE+ + +
Sbjct: 1547 RKMKKEAASLSEWLSATETEL--VQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTI 1604
Query: 2963 KEALAGLLVTYPNSQEAENWKKIQEE----LNSRWERATEVTVARQRQLEESASHLACFQ 3018
E+ A L E + I EE LN+ W R T L + L F
Sbjct: 1605 TESSAAL------QNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFD 1658
Query: 3019 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 3078
+ + WL + E ++ I+ + Q++ V+ ++ E + Q E + + A
Sbjct: 1659 GNVAHISTWLYQAEALLD-----EIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALI 1713
Query: 3079 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 3138
++ G S S V+ +L +N+ + +++ + S I Q YQ L ++ +
Sbjct: 1714 LMNARG--SSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQ----EPLYQCL---VTTE 1764
Query: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
G S + E + + +E+ E + E++D E + + + ++ Q
Sbjct: 1765 TFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEML-HQP 1823
Query: 3199 LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL--------D 3250
++D K+++ L L R N+++A ++ Q+ +R+ L
Sbjct: 1824 MEDNKKEKIRLQLL-------LLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEI 1876
Query: 3251 DKQSQQAKNCPISAKLERLQSQLQENEEFQ-------KSLNQHSGSYEVIVAEGESLLLS 3303
+K + +S + L + + E+ FQ K G ++ E + ++
Sbjct: 1877 NKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVIL 1936
Query: 3304 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 3363
G E +++ L +L W+ +++ +DR+ M++ +++ + DL WI + +
Sbjct: 1937 EASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAE 1996
Query: 3364 AKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINS-SEADEDGIRD 3422
+ + + LE + + + + + + LN D ++ S+AD +++
Sbjct: 1997 ELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKE 2056
Query: 3423 EKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQ 3482
+ AG+NQ DA+ E++ + L+ ++++ +++ I + A+H ++ S
Sbjct: 2057 KLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ----KRST 2112
Query: 3483 ACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVED----APDGSDASQLLHQAEVAQQ 3538
+NL++LR + ++ ++ +L ++ D P+ S+ L +
Sbjct: 2113 TELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWN 2172
Query: 3539 EFLEVKQRVNSGCVMMENKLEGIG-QFHCRVREM------------------FSQLADLD 3579
+ C+ + + H V+++ S ADLD
Sbjct: 2173 KICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLD 2232
Query: 3580 DEL----DGMGAIGRDTDS---LQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3632
+ D + I + S +E++ ++++ + K D+E + ++
Sbjct: 2233 KTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQN 2292
Query: 3633 LDLLGLKRELE-ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA- 3690
L ++ A+ ++ ++ + Q +EL ++ED +D EE
Sbjct: 2293 LKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELM 2352
Query: 3691 ---EALQWVV-GTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDV 3746
EA +++ + + +Q++D ++ +E + P + + + Q L++ G D D
Sbjct: 2353 RKYEARLYILQQARRDPLTKQISDNQILLQE-LGPGDGIVMAFDNVLQKLLEEYGSD-DT 2410
Query: 3747 QGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQK 3806
+ ++ E + W L + +A R L+ + LE L W+ + E +
Sbjct: 2411 RNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLV 2470
Query: 3807 PPSAEYKVVKAQIQEQKLLQRLLDDRKATVD-----MLQAEGGRIAQSAELADREKIT-- 3859
S ++ I ++L Q+ + D +A +D +G R L + E+ T
Sbjct: 2471 DASHRENALQDSILARELKQQ-MQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATML 2529
Query: 3860 -GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
+L+ + RW +L +K+A+ + LE + + E + +L++ +++L P+G
Sbjct: 2530 QHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIG 2589
Query: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAV 3949
+Q Q KAL +++ V AV
Sbjct: 2590 GDVPALQLQYDHCKALRRELKEKEYSVLNAV 2620
Score = 83.6 bits (205), Expect = 5e-15
Identities = 202/1115 (18%), Positives = 449/1115 (40%), Gaps = 144/1115 (12%)
Query: 1847 LERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDT---WN 1903
LE +++++ V + LE ++ + E AQ+ + L++ + L + +
Sbjct: 1778 LENDIENMLKFVEKHLESSDED--EKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQ 1835
Query: 1904 SRLLHFQ----NAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSL 1959
LLH + A+ I++ K+ + + L V ++L ++V L
Sbjct: 1836 LLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPEL 1895
Query: 1960 NLCLQQYEDL---KQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRS 2016
N + YED + + K QLD L I + + + +++
Sbjct: 1896 NTAI--YEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQI------- 1946
Query: 2017 FQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQ 2076
+D L Q A+ D + + +++ ++ H L DL W+ +AE L
Sbjct: 1947 -RDTLTQLNAKWDRI--NRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTC 2003
Query: 2077 GRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALRE 2136
DL + +Q ++L+ I + SFA + + +G ++ KLS + + L+E
Sbjct: 2004 APGGSLDLEKARIHQ---QELEVGISSHQPSFAALNRTGDGIVQ----KLSQADGSFLKE 2056
Query: 2137 KLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTS 2196
KL ++++A+ E + Q L+ +K++ + + ++D ++ W+T
Sbjct: 2057 KLAGLNQRWDAIVAEVKDRQPRLKGE--------------SKQVMKYRHQLDEIICWLTK 2102
Query: 2197 VGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLS 2256
+ M++ S L + + D + EKL + + E+LS
Sbjct: 2103 AEHA----------MQKRSTTELGENLQELRDLTQEMEVHAEKL----KWLNRTELEMLS 2148
Query: 2257 QQQNFILATQSAQAFL---DQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQ 2313
+ + L + + + E L++ + E T +A + +++V
Sbjct: 2149 DKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIA-AHPNVQKVV 2207
Query: 2314 TLQDELQKFLQDHK---------------EFESWLERSEKELENMHKGGSSPETLPSLLK 2358
+ +Q H+ E WL ++ L++ E + +
Sbjct: 2208 LVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVS 2267
Query: 2359 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 2418
R D+ L +V Q + + +S S++ + +KL+ ++
Sbjct: 2268 RMKITKADLEQRHPQLDYVFTLAQNLKNKASS-------SDMRTAITEKLERVKNQWDGT 2320
Query: 2419 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 2478
L ++ Q+ + + + M+ EA + L DP L +Q++
Sbjct: 2321 QHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYIL--QQARRDP--LTKQISD 2376
Query: 2479 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER 2538
+ L +EL V V + ++E G + D R+V+ETT+ + + + +L S+A+R
Sbjct: 2377 NQILLQELGPGDGIVMAFDNVLQKLLEEYG--SDDTRNVKETTEYLKTSWINLKQSIADR 2434
Query: 2539 SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEA-LATNMKLK-QD 2596
+ L+ Q+ + LE+ L+ I E E + +S +Q++ LA +K + QD
Sbjct: 2435 QNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQD 2494
Query: 2597 IARQ-------KSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKES 2649
I + S++ R+ + + + +S A +LQ +L +++QR+ L + K +
Sbjct: 2495 IQAEIDAHNDIFKSIDGNRQKMVKAL--GNSEEATMLQHRLDDMNQRWNDL----KAKSA 2548
Query: 2650 SLK-KLLPQAEMFEHLSGKLQQFM--------ENKSRMLASGNQPDQDITHFFQQIQELN 2700
S++ L AE + L L++ + E K +M G+ P + + + L
Sbjct: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQ--YDHCKALR 2606
Query: 2701 LEMEDQQEN-LDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFT---ELQKTVKEREKD 2756
E+++++ + L+ ++ L+ ++ + R + + T QK K K
Sbjct: 2607 RELKEKEYSVLNAVDQARVFLAD--QPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQ 2664
Query: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT 2816
+S +E+ + + +QK + + + + +M +L+ ++ +S+ + W G
Sbjct: 2665 SSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMD--DLDADMKEAESVRNGWKPVGD 2722
Query: 2817 LVEEINCKGTSLENLIM---EITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCD 2873
L+ I+ +E ++ EI + + KT + + S + ++ + + K +
Sbjct: 2723 LL--IDSLQDHIEKIMAFREEIAPINFKVKT---VNDLSSQLSPLDLHPSLK----MSRQ 2773
Query: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE 2908
+ D+N++++ L Q S+ L +++E H++
Sbjct: 2774 LDDLNMRWKLL-------QVSVDDRLKQLQEAHRD 2801
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 258 bits (658), Expect = 2e-67
Identities = 471/2461 (19%), Positives = 979/2461 (39%), Gaps = 246/2461 (9%)
Query: 2977 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 3036
+ AE+ ++ ++++ R+ R E++ R+++LE+S FQ +L W+ EK +
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQEK--LQI 66
Query: 3037 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKE 3096
DP L + Q+ Q E +A +L+E +++ + ++ ++
Sbjct: 67 ASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTR 123
Query: 3097 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQP 3156
L ++++W L +K+ + +K Q Q+L+Q L E V ++ + AI T
Sbjct: 124 LMELHRQWELLLEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSE 175
Query: 3157 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV----LIGEQYLKDEL-KKRLETVA 3211
E + Q LE ++ E+ ++ + +E++ LI EQ+ ++EL K + + V
Sbjct: 176 E-LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
Query: 3212 LPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQS 3271
Q L+ LA R +L A A Q+F + DE +W+ +K+ A + L +Q+
Sbjct: 235 AAWQRLKGLALQRQGKLFGA-AEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQA 292
Query: 3272 QLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 3331
L+++E ++ L + + AE + L S P + +Q + EL +WE++
Sbjct: 293 LLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ--IQVKREELITNWEQIRTLA 350
Query: 3332 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE 3391
A+R +RL D + Q++ DL W+ + KA ++ + D E+ L R + E
Sbjct: 351 AERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGE 409
Query: 3392 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMT-- 3449
++ + + + L+ + D +R++ +++ A+ E + + E+
Sbjct: 410 IDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDL 469
Query: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE----KLRAQQEVLQALEPQ 3505
Q E N K E ++ D+L S K E L AQ+E + AL+
Sbjct: 470 QLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEF 529
Query: 3506 VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFH 3565
L +ED DA LL + + + + ++ + ++ +
Sbjct: 530 ATKLIQNNHYAMEDVATRRDA--LLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELK 586
Query: 3566 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA---- 3621
V E D +D +LQ +++ + F ++ + I+A E
Sbjct: 587 SWVNEKMKTATD---------EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
Query: 3622 --ECRHMLEEEGTL---DLLGL-KRELEALNKQCGKLTERGKARQ-----EQLELTLGRV 3670
+ H ++E +++ L K+ LEA + KL E + +Q E +EL L V
Sbjct: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEV 697
Query: 3671 EDFYRKLKGLNDATTAA--EEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3728
E D T ++ AL E ++ Q +++D + ++ +Q
Sbjct: 698 EGHLASDDYGKDLTNVQNLQKKHAL-----LEADVAAHQ---------DRIDGITIQARQ 743
Query: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDAL 3788
G D + ++ E + AR+ L + + R +L ++L F+D +
Sbjct: 744 FQDAGH---------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-V 793
Query: 3789 EPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ 3848
E +W+ + E + A+ + V+ +++ + LQ + + + + +G + +
Sbjct: 794 EDEETWIREKEPIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE 852
Query: 3849 SAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908
A E + +L L +W L +KA+ R++ LED L A+Q+ A ++ E
Sbjct: 853 EGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQQYFADANEAESWMREKE 910
Query: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
+ S G + + +H+AL D+ + + + + QS +P +
Sbjct: 911 P-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
Query: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN------WLAEVEDK--- 4019
E + +L + Q++ R+ + D + +LN W EV D+
Sbjct: 970 ELVLALY----DYQEKSPREVTMKKG----------DILTLLNSTNKDWWKVEVNDRQGF 1015
Query: 4020 LSSVFVKDF-------KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
+ + +VK ++++L Q + +AL +E ++ + + + + +KQ
Sbjct: 1016 VPAAYVKKLDPAQSASRENLLEEQGS--IALRQEQIDNQTRITKEAGSVSLRMKQ----- 1068
Query: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
++ Y + K LE++ + F+ EL W+ E E L TS
Sbjct: 1069 ----------VEELYHSLLELGEKRKGMLEKSCKKFMLFREA-NELQQWINEKEAAL-TS 1116
Query: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL---------LELV------ 4177
EQ+ Q++ + +K++ + L +N+V+ L ++ V
Sbjct: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
Query: 4178 --------------PWRAREGLDKLVS------DANEQYKLVSDTIGQRVDEIDAAIQRS 4217
PW++ + V+ + NE+++ + +R + +A
Sbjct: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA-HEV 1235
Query: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK--AFSIDIIRHKDSMDEL 4275
Q++ + AD W+ E K AL D + Q +K F D+ D ++ L
Sbjct: 1236 QRFHRDADETKEWIEE---KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 1292
Query: 4276 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 4335
+ + E + LQEK L Q + ++ +R A+L + L +F + +
Sbjct: 1293 GETAERLIQSHPESAED-LQEKCTELNQAWSSLGKRADQRKAKLGDSHDL-QRFLSDFRD 1350
Query: 4336 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL-------KIG 4388
L WI R L++ ++L + L E EH+ ID + G
Sbjct: 1351 LMSWINGIRGLVSS--------DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402
Query: 4389 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPML 4448
QL +++K + A +++ QR + LD+ + ++ FH E
Sbjct: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL----ELQLFHRDCEQAE 1458
Query: 4449 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508
+ + L + +D + I ++ + + AL+ ++LI
Sbjct: 1459 NWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHY 1517
Query: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQ 4568
A D++++ + LD+ W +KA+ E+ K L + ++F D+ + I +
Sbjct: 1518 AKGDISSRR-NEVLDR----WRRLKAQMIEKRSK-LGESQTLQQFSRDVDEIEAWISEKL 1571
Query: 4569 DIVHD---LESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIF--ACGETE 4623
D + I S + + + + + E + + + +G LI AC +E
Sbjct: 1572 QTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE 1631
Query: 4624 KPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683
V+ + + + W+ L + E+ +KL++A + Q +T FD+ + V L
Sbjct: 1632 DA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ--QNFNTGIKDFDFWLSEVEALLAS 1688
Query: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
G DL +V + L + + + ++ + ++ LN Q + ++ + +T + +++
Sbjct: 1689 EDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ--VKDKRDT 1746
Query: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
+ ++ + A R+ KL + L QF +++ SW+ ++LL D +
Sbjct: 1747 INGRFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKE-KKLLVGSEDYGRDLTGV 1804
Query: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4863
+ KH L+ ++ AH+ ++ V G +L + + ++ RL + W+ + Q
Sbjct: 1805 QNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT-IGKEEIQQRLAQFVEHWKELKQL 1863
Query: 4864 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4923
R Q+L+ +L+ Q F + +E+ + + L AS+ G + L H
Sbjct: 1864 AAARGQRLEESLEYQQ-FVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFE 1921
Query: 4924 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983
+ ++ N + G+ ++ + ++ + L K + +RK+KL+E
Sbjct: 1922 TDFTVHKDRVNDVCTNGQDLI--KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1979
Query: 4984 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ- 5042
+ +F +W+ E SL L++V + + + + F + A + +
Sbjct: 1980 N-SAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
Query: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
I + +QL Q I+ S+ RW +++ S R + L +A+ ++ +
Sbjct: 2038 IANITALKDQLLAAKHVQSKA-IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2096
Query: 5103 AWKKLI-------DWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTT 5155
+ W E+AE L + N ++IK H F+ +L Q ++
Sbjct: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRC-NSLEEIKALREAHDAFRSSLSSAQADFNQL 2155
Query: 5156 IRTGRALKEKTLLPEDSQKLDNFLGE-VRDKWDTVCGKSVER-------QHKLEEALLFS 5207
R +K + S F E + + W + ER Q + EE
Sbjct: 2156 AELDRQIKSFRVA---SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR 2212
Query: 5208 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 5267
+F A W+ + L + + + + + ++A K +E+ ++ ++
Sbjct: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIED 2272
Query: 5268 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
G + E D + + L+ +WD + +L + Q LEQ ++ T L E
Sbjct: 2273 LGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKE 2332
Query: 5328 W 5328
+
Sbjct: 2333 F 2333
Score = 250 bits (639), Expect = 3e-65
Identities = 419/2048 (20%), Positives = 847/2048 (41%), Gaps = 200/2048 (9%)
Query: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
P G + + +Q+ L+ R + KLE +F R+ + +
Sbjct: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
Query: 3581 ELD-GMGAIGRDTDSLQSQIEDVRLFLNKIH-----VLKLDIEASEAECRHMLEEEGTLD 3634
+L +D +LQ +++ + F ++ ++KLD E +++ EG
Sbjct: 63 KLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD------ETGNLMISEGHFA 116
Query: 3635 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL- 3693
++ L L++Q L E K R++ ++L + + + L+ D + EA+
Sbjct: 117 SETIRTRLMELHRQWELLLE--KMREKGIKLL--QAQKLVQYLRECEDVMDWINDKEAIV 172
Query: 3694 -QWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD 3752
+G ++E + F+ FQ + + ++ +VN LIQ + ++ ++
Sbjct: 173 TSEELGQDLEHVEVLQKKFEEFQTDMAAH-EERVNEVNQFAAKLIQEQHPEEEL--IKTK 229
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812
+E+NA W L QR +L A +F ++ +SW+ + E+L+A+ +
Sbjct: 230 QDEVNAAWQRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDL 287
Query: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872
V+A +++ + L+R L + V L AE R+ QS L+ + I + E L + W ++
Sbjct: 288 ASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ-IQVKREELITNWEQI 346
Query: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE-----KKLANSEPVGTQTAKIQQQ 3927
+ AA R +L D L + ++DF +T K L N++ + + A +
Sbjct: 347 RTLAAERHARLNDSYRLQRF-------LADFRDLTSWVTEMKALINADELASDVAGAEAL 399
Query: 3928 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+ RH+ + +I+ H A + GQ+L + A V EK+ L + + +
Sbjct: 400 LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV-REKLTVLSEERAALLELWEL 458
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
+ +Q + + +LF D +V NW+++ E L L+ D L E +
Sbjct: 459 RRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFL------------LNEDLGDSLDSVEAL 505
Query: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTRYADITVTSSKAL--RTLE 4102
+ + ++ ++++ + + LIQ ++ + TR D ++ AL R +
Sbjct: 506 LKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATR-RDALLSRRNALHERAMR 564
Query: 4103 QARQLATKFQSTY-----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 4157
+ QLA F +EL W+ E + + P+ Q Q+ + + E+
Sbjct: 565 RRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV--QKHQAFEAELS 622
Query: 4158 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 4217
++ +D + + + L+++ + A++ + +++ +K + + + ++ A Q+
Sbjct: 623 ANQSRIDALEKAGQKLIDVNHY-AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
Query: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSI---DIIRHKDSMDE 4274
Q D EL W+ E + L + +D T Q +QK ++ D+ H+D +D
Sbjct: 682 QFNRNVEDIEL-WLYEVEGHLASDD---YGKDLTNVQ-NLQKKHALLEADVAAHQDRIDG 736
Query: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
+ + ++ F G +++K E+L+ +YEA+ R +L + + + Q + E
Sbjct: 737 I-TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS-LRLQQLFRDVE 794
Query: 4335 ELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 4394
+ WI E + A + D ++ ++ + L+ IA H+P I K +
Sbjct: 795 DEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRI----------KAV 843
Query: 4395 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 4454
+ MVEE + AE++ A++ E+ Q+ AL SQ Q E + +
Sbjct: 844 TQKGNAMVEEGHFAAEDVKAKL-HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
Query: 4455 SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG---EELIGRSQGADK 4511
S +R I D + D SA L+K + L G + L ++Q +
Sbjct: 903 ESWMREKEPIVGSTDYGK----DEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQ 958
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLEL---AEKFWYDMAALLTTIKDTQ 4568
+A + + + ++ ++ + E +K D+L L K W+ + + D Q
Sbjct: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-----VNDRQ 1013
Query: 4569 DIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI----RILGADLIFACGETEK 4624
V +DP+ Q + E + EE + E I RI E
Sbjct: 1014 GFVPAAYVKKLDPA----QSASRENLLEEQGSIALRQEQIDNQTRIT----------KEA 1059
Query: 4625 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4684
V + ++ + +L + ++R LE + + + +++ + W++ L T
Sbjct: 1060 GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAAL-TSE 1117
Query: 4685 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE------LMLKKAT--------- 4729
VG DL V+ + +F+ ++ + ++ +N E LM ++
Sbjct: 1118 EVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYG 1177
Query: 4730 ----DETDRDIIR---------------EPLTELKHLWENLGEKIAHRQHKLEGALLALG 4770
DETD + EL W +L +++A + +L G+ +
Sbjct: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQ 1236
Query: 4771 QFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKA 4830
+F +E W+ + L+ D ++ KH + D+ A V ++ +
Sbjct: 1237 RFHRDADETKEWIEEKNQALNTDN-YGHDLASVQALQRKHEGFERDLAALGDKVNSLGET 1295
Query: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890
L++S + A L+ + +NQ W S+ ++ ++R+ +L + Q F S+ D +
Sbjct: 1296 AERLIQSHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMS 1353
Query: 4891 ELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS 4950
+ + +S+ + + A L+ H E +++ A+ T+ G+ +L
Sbjct: 1354 WINGIRGLVSSDELAKDVTG-AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GH 1410
Query: 4951 GSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLN 5010
+ + +Q + +L+Q+ + +R+ L++ L L F ++ NW+ E LN
Sbjct: 1411 YASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQL-FHRDCEQAENWMAAREAFLN 1469
Query: 5011 IASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQ--KQDVVLIKNL 5068
L++V + I++H+ F +N ++I L +QL K D+ +N
Sbjct: 1470 TEDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRN- 1527
Query: 5069 LVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDP 5128
V RW ++ + IE+ L +++ +QF ++ W+ +E + E DP
Sbjct: 1528 --EVLDRWRRLKAQMIEKRSKLGESQT-LQQFSRDVDEIEAWI--SEKLQTASDESYKDP 1582
Query: 5129 DKIKLQ--LSKHKE---FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVR 5183
I+L LSKH++ F+ L I G +L E+ + L +
Sbjct: 1583 TNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALA 1642
Query: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHG-DLDLVM 5242
D+W + KS E+ KL+EA F ++ WL +VE LA + +G DL V
Sbjct: 1643 DQWQFLVQKSAEKSQKLKEANK-QQNFNTGIKDFDFWLSEVEALLASED--YGKDLASVN 1699
Query: 5243 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 5302
NL+ H++ + ++ ++ L L+ +S DT+ VK + ++ R+ + ++
Sbjct: 1700 NLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAA 1759
Query: 5303 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKK 5362
S++++L ++ + + FRD + W+ E ++ L D +Q+L HK +
Sbjct: 1760 SRRAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAE 1817
Query: 5363 VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARF----EEVLTWAKQHQQRLE 5418
+ + + G+ + D T K I A+F +E+ A QRLE
Sbjct: 1818 LAAHEPAIQGVLDTGKKL-----SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLE 1872
Query: 5419 TAL--SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476
+L + VAN +EE AWI T + D + ++ L+ +H+ F + T
Sbjct: 1873 ESLEYQQFVAN---VEEEEAWINEKMTLVASED---YGDTLAAIQGLLKKHEAFETDFTV 1926
Query: 5477 KQPDVDRV 5484
+ V+ V
Sbjct: 1927 HKDRVNDV 1934
Score = 188 bits (477), Expect = 2e-46
Identities = 443/2389 (18%), Positives = 917/2389 (38%), Gaps = 310/2389 (12%)
Query: 2035 LQQMEQEALVKTLQKQQNTCH-QQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 2093
L++M ++ +K LQ Q+ + ++ ED+ W+ E + + QDL ++ Q
Sbjct: 135 LEKMREKG-IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEE---LGQDLEHVEVLQKK 190
Query: 2094 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR 2153
++ Q D+ EE +++ ++E+ H +E + Q+E
Sbjct: 191 FEEFQTDMAAH---------------EERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVN 234
Query: 2154 VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ 2213
A + L+ ALQ++ + AA E+ + +D + W+ EQ
Sbjct: 235 AAWQRLKGL---ALQRQGKLFGAA-EVQRFNRDVDETISWIKE--------------KEQ 276
Query: 2214 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 2273
L + L + + + E L++ ++ + + L ++
Sbjct: 277 LMASDDFGRDLASVQALL---RKHEGLERDLAALEDKVKALCAEADRL------------ 321
Query: 2274 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 2333
Q H L+ + Q+ +++L EQ T A+ A L LQ+FL D ++ SW+
Sbjct: 322 QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY----RLQRFLADFRDLTSWV 377
Query: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
K L N + S +LL R ++ +H+ + SGQ +L
Sbjct: 378 TEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL-------- 428
Query: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ------FQNSADSLQ 2447
G+ D+++ E+ T L + L + QY Q F + +
Sbjct: 429 -----AAGHYASDEVR---EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
Query: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507
WM EA LL++ + ++ L + ++ L+ + + L + A +++
Sbjct: 481 NWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN 537
Query: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES--LESLLQSIGE 2565
D V D++LS +L R + L + Q ++S L+S + +
Sbjct: 538 HYAMED---VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594
Query: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
+ K S+L G +Q+ A +L + +R + +A ++++ D A
Sbjct: 595 TATDEAYKDPSNLQ-GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA-- 651
Query: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQP 2685
++ EV +++L + K L++ Q + F ++ ++ LAS +
Sbjct: 652 ---RMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVEDIELWLYEVEGHLASDDY- 706
Query: 2686 DQDITHFFQQIQE----LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2741
+D+T+ Q +Q+ L ++ Q+ +D + + G H D +N++K
Sbjct: 707 GKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAG-------HFD-AENIKK 757
Query: 2742 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTF------QKWLKETEGSIPPTETSMSAK 2795
L + ++ + +++L + +L + F + W++E E T
Sbjct: 758 KQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLI 817
Query: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855
++ ++ ++L + A ++ + KG ++
Sbjct: 818 GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE------------------------- 852
Query: 2856 GSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2915
G+ +D ++ + ++N K+E L +R++ L+ L + ++ +AN W
Sbjct: 853 ---EGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESW 905
Query: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA---------- 2965
+ KE ++ S D E A + ++A +++L IQ ++E
Sbjct: 906 MREKEPIVGSTDYGKDEDSAE---ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962
Query: 2966 --------LAGLLVTYPNSQEAENWKK---IQEELNSRWERATEVTVARQRQLEESASHL 3014
L L Y E K I LNS + +V V RQ A+++
Sbjct: 963 TDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEV-NDRQGFVPAAYV 1021
Query: 3015 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
A+S R L+E++ + + + + + V +K+ E +L E
Sbjct: 1022 KKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGE 1081
Query: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQD 3134
+G+L + + + Q IN+K LT + + ++Q V ++ + +D
Sbjct: 1082 KRKGMLEKSCKKFMLFREANELQQWINEKEAALTSE--EVGADLEQVEVLQKKFDDFQKD 1139
Query: 3135 LS------EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCD 3188
L + + V + L + ++ + +AV+QQ E+ + + + + K A
Sbjct: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETDSKTASPW-K 1193
Query: 3189 ELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 3248
+++ + +K+ E + L+ LA +R ++L + Q+F + DE + W
Sbjct: 1194 SARLMVHTVATFNSIKELNER----WRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEW 1248
Query: 3249 LDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE 3308
+++K +Q L +Q+ +++E F++ L + E L+ S P E
Sbjct: 1249 IEEK-NQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP--E 1305
Query: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368
LQ + EL W L K+ R+++L D Q++ DL+ WI + +S
Sbjct: 1306 SAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSS 1364
Query: 3369 LRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE------------AD 3416
+ D E+ L R + E++ R + L+ D
Sbjct: 1365 DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILD 1424
Query: 3417 EDGIRDEKAGINQNMDAVTEELQAKTGSLE-EMTQRLREFQESFKNIEKKVEGAKHQLEI 3475
++ EKA + + M + + L+ + + E + +E+F N E K +
Sbjct: 1425 QERADLEKAWVQRRM-MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDS------- 1476
Query: 3476 FDALGSQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3534
D++ + +++ +K + Q+E + AL+ D L G S +++L +
Sbjct: 1477 LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWR 1534
Query: 3535 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDS 3594
+ + +E + ++ + Q + DE++ + T S
Sbjct: 1535 RLKAQMIEKRSKLGES-------------------QTLQQFSRDVDEIEAWISEKLQTAS 1575
Query: 3595 LQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EGTLDLLGLKRELEALNKQCGKLT 3653
+S + + L+K+ +A EAE + G +D+ E A +
Sbjct: 1576 DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVK 1635
Query: 3654 ERGKARQEQLELTLGRVEDFYRKLK----------GLNDATTAAEEAEAL--QWVVGTEV 3701
R A +Q + + + + +KLK G+ D E EAL G ++
Sbjct: 1636 ARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDL 1695
Query: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3761
+N L ++ + + + + +L+ +N L+ S+ D ++ + IN R+
Sbjct: 1696 ASVNNLLKKHQLLEAD-ISAHEDRLKDLNSQADSLMTSSA--FDTSQVKDKRDTINGRFQ 1752
Query: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3821
+ A R A+L E+ F+D ++ SW+ + ++L+ + + V+ ++
Sbjct: 1753 KIKSMAASRRAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKK 1810
Query: 3822 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3881
K L+ L + + + G +++ + +E+I +L W EL AAAR +
Sbjct: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIG-KEEIQQRLAQFVEHWKELKQLAAARGQ 1869
Query: 3882 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENH 3941
+LE+ L +QF E +++ + L SE G A IQ + +H+A E D H
Sbjct: 1870 RLEESLEY-QQFVANVEEEEAWIN-EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVH 1927
Query: 3942 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL 4001
V+ GQ L + E+ + S K+ L + S+++ ++ A LD+ + +
Sbjct: 1928 KDRVNDVCTNGQDLIKKNNHHEENI-SSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
Query: 4002 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV--DQAIK 4059
+ +V V +W+ E E+ L + D+ +D+ L +E + + I
Sbjct: 1987 NWKADV-VESWIGEKENSLKT---DDYGRDL---SSVQTLLTKQETFDAGLQAFQQEGIA 2039
Query: 4060 NGQALLKQTTGEEVL---LIQEKLDGIKTRYADITVTSSKALRTLEQAR-------QLAT 4109
N AL Q + + I+ + + R++ + S+ + L +A+ L
Sbjct: 2040 NITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2099
Query: 4110 KFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 4169
F W EE+L T + + E+I ++ + + + + + E+
Sbjct: 2100 TFAKKASAFNSWFENAEEDL-TDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAEL 2158
Query: 4170 SRALLEL------VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS------ 4217
R + W E L+ E ++ + I +R E+ +R
Sbjct: 2159 DRQIKSFRVASNPYTWFTMEALE-------ETWRNLQKIIKERELELQKEQRRQEENDKL 2211
Query: 4218 -QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELF 4276
Q++ Q A+A W+ ET+ L+ + E +QL+ K +I + + ++
Sbjct: 2212 RQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKI- 2270
Query: 4277 SHRSEIFGTCGEE----QKTVLQEKTESLIQQYEAISLLNSERYARLER 4321
E G EE + T L QQ++ + L LE+
Sbjct: 2271 ----EDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2315
Score = 168 bits (425), Expect = 2e-40
Identities = 331/1803 (18%), Positives = 726/1803 (40%), Gaps = 216/1803 (11%)
Query: 3852 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3911
L E I + + + R+ + R+++LED + F AE + ++ EK
Sbjct: 9 LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRF-QFFQRDAEELEKWIQ--EKLQ 65
Query: 3912 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3971
S+ +Q ++ +H+A E +++ ++ + + + G + S A + + + +
Sbjct: 66 IASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
Query: 3972 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 4031
+ L ++ + ++ K L QA + E E +V++W + DK + V ++ QD
Sbjct: 126 E-LHRQWELLLEKMREKGIKLLQAQKLVQYLRECE-DVMDW---INDKEAIVTSEELGQD 180
Query: 4032 VLH--------RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083
+ H + +A +EE VN + A L Q E LI+ K D +
Sbjct: 181 LEHVEVLQKKFEEFQTDMAAHEERVNE-------VNQFAAKLIQEQHPEEELIKTKQDEV 233
Query: 4084 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIP 4143
+ + + + L A ++ +F +E W++E +E+L S +
Sbjct: 234 NAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETISWIKE-KEQLMASDDFGRDLASVQ 291
Query: 4144 QFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVS 4200
++ + L++++ + + + L + P A + ++L+++ + L +
Sbjct: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
Query: 4201 DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA 4260
+ + D R Q++ +WV E K + A D+ + + +A
Sbjct: 352 ERHARLNDSY-----RLQRFLADFRDLTSWVTEMKALINA--------DELASDVAGAEA 398
Query: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320
+ RH++ E+ +H F + E + +L + + E +++L+ ER A LE
Sbjct: 399 L---LDRHQEHKGEIDAHEDS-FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
Query: 4321 RAQVLVNQ---------FWETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQ 4369
++ Q F+ E++ W+ + A + L E L ++ E+ +
Sbjct: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
Query: 4370 LRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 4429
S++ + I L + +L + N E V + + + + +RA+
Sbjct: 515 ---SLSAQEEKITALDEFATKLIQNNHYAMEDVATR----RDALLSRRNALHERAMRRRA 567
Query: 4430 AVSQSTQITEFH---DKIEPML-ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVEL 4485
++ S + +F D+++ + E ++ + P ++ + +++ EL
Sbjct: 568 QLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP------SNLQGKVQKHQAFEAEL 621
Query: 4486 EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED---------IKARA 4536
Q +AL++ G++LI + A ++AA+ +++++ W+ IK R
Sbjct: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAAR-----MNEVISLWKKLLEATELKGIKLRE 676
Query: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4596
++ +F +E E + Y++ L + +D+ + Q ++ + E
Sbjct: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN------------VQNLQKKHALLE 724
Query: 4597 ETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4656
H++ + A G + ++K + + +E L + R +KL D++
Sbjct: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
Query: 4657 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4716
+ ++D ++ W+ + G DL V++ L + + + E+ + ++
Sbjct: 785 RLQQLFRD-VEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
Query: 4717 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHAL 4776
+ +G M+++ + ++ L EL WE L K + R+ LE +L A F A
Sbjct: 843 VTQKGNAMVEEGHFAAED--VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA- 899
Query: 4777 EELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLE 4836
E SW+ E ++ + D E L KH L +D+ A+ ++++ + + +
Sbjct: 900 NEAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQ 958
Query: 4837 SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRME 4896
A D + + + A+ E ++ ++ + + L ++E
Sbjct: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE---------- 1008
Query: 4897 SQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR--DDSGSGS 4954
+ G +P ++LD +Q ++E N L ++G + L D+ +
Sbjct: 1009 ----VNDRQGFVPAAYVKKLDP-----AQSASRE---NLLEEQGSIALRQEQIDNQTRIT 1056
Query: 4955 KTEQSVAL----LEQKWHVVSSKMEERKSKLEEALNLATEFQ--NSLQEFINWLTLAEQS 5008
K SV+L +E+ +H + E+RK LE++ F+ N LQ++IN A S
Sbjct: 1057 KEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
Query: 5009 LNIASPPSLI-----------------------LNTVLSQIEEHKVFANEVNAHRDQII- 5044
+ + + +N V +E + A EV A + Q +
Sbjct: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
Query: 5045 ------ELD-QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
E D +T + K V N + + RW + Q + ER + L A +
Sbjct: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHE-V 1235
Query: 5098 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157
++FH + +W+E+ L+++ +D ++ KH+ F++ L ++
Sbjct: 1236 QRFHRDADETKEWIEEKNQALNTD-NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGE 1294
Query: 5158 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
T L + PE ++ L E+ W ++ ++ +R+ KL ++ +F+ + L
Sbjct: 1295 TAERLIQSH--PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
Query: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277
+ W+ + ++ D+ + D+ L++ H+ + E+ R GT Q ++ G++L+ +
Sbjct: 1352 MSWINGIRGLVSSDE-LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
Query: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
+ +K +L L + K V ++ L+Q L + ++F W++ E L
Sbjct: 1411 YASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAFLN 1469
Query: 5338 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 5397
D +++++LI H++F K + + + + A + ++A H +
Sbjct: 1470 TEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGH--------YAKG 1520
Query: 5398 IIRARFEEVLT-WAKQHQQRLETALSELVANAEL------LEELLAWI-QWAETTLIQRD 5449
I +R EVL W + Q +E S+L + L ++E+ AWI + +T +
Sbjct: 1521 DISSRRNEVLDRWRRLKAQMIEKR-SKLGESQTLQQFSRDVDEIEAWISEKLQTASDESY 1579
Query: 5450 QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR 5509
++P + ++ + +HQ F E+ + DR+ N IE+ G
Sbjct: 1580 KDPTNIQLSKLLSKHQKHQAFEAEL---HANADRIRGVIDMGN------SLIERGACAGS 1630
Query: 5510 KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFAN 5569
+ +A R+ L+ +WQ + + E+ +KL +A + +
Sbjct: 1631 E----------------DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKD 1674
Query: 5570 FDF 5572
FDF
Sbjct: 1675 FDF 1677
Score = 162 bits (410), Expect = 9e-39
Identities = 441/2392 (18%), Positives = 914/2392 (38%), Gaps = 286/2392 (11%)
Query: 2212 EQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAF 2271
E+L EK + + + Y KL K HQ ++ Q A A
Sbjct: 54 EELEKWIQEKLQIASDENYKDPTNLQGKLQK--------HQAFEAEVQ----ANSGAIVK 101
Query: 2272 LDQHGHNLTPE---EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ-DELQKFLQDHK 2327
LD+ G+ + E + ++ +L EL Q+ L + K ++ LQ +L ++L++ +
Sbjct: 102 LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMRE--KGIKLLQAQKLVQYLRECE 159
Query: 2328 EFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDM 2387
+ W+ E + + G E + L K+ F D+ +H+ + V K++
Sbjct: 160 DVMDWINDKEA-IVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE 218
Query: 2388 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 2447
++ +E L+K K + + L + L + +F D
Sbjct: 219 QHPEEE---------LIKTKQDEVNAAWQRLKGLALQRQGKL-FGAAEVQRFNRDVDETI 268
Query: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507
+W++ E + + SD D +Q L + L+ +LA + +K++ + + ++
Sbjct: 269 SWIKEKE---QLMASDDFGRDLASVQALLRKHEGLERDLAALE---DKVKALCAEADRLQ 322
Query: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567
+Q + ++++++ + AER + L + + Q L + E++
Sbjct: 323 QSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMK 381
Query: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQ 2627
+ +++S +G + L + + K +I + S ++ E + + V +
Sbjct: 382 ALINADELASDVAGA-EALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVRE 440
Query: 2628 GKLAEVSQR------FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2681
KL +S+ +L QQ E+ L+ E ++ K + F+ N
Sbjct: 441 -KLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN------- 492
Query: 2682 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQ----DRVQ 2737
+D+ ++ L + ED +++L E +T L FA L Q+ + V
Sbjct: 493 -----EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE--FATKLIQNNHYAMEDVA 545
Query: 2738 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2797
R + + ER A + QL + L + F+ + EL
Sbjct: 546 TRRDALLSRRNALHER---AMRRRAQLADSFHLQQFFR-----------------DSDEL 585
Query: 2798 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2857
+ + D A K + N +G ++ E +Q + + L G +
Sbjct: 586 KSWVNEKMKTATDEAYK----DPSNLQGKVQKHQAFEAELSANQSRIDA-LEKAGQKLID 640
Query: 2858 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2917
VN H KD E+ M++V ++KL + L+ N+ ++ ++ + WL
Sbjct: 641 VN--HYAKD--EVAARMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVEDIELWLY 695
Query: 2918 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2977
E L S D T + ++ K L E + + ++ + G+ + Q
Sbjct: 696 EVEGHLASDDYGKDLTNVQNLQ-----KKHALLEAD-----VAAHQDRIDGITIQARQFQ 745
Query: 2978 EA-----ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
+A EN KK QE L +R+E E VAR+++L +S F+ E + W+ EKE
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE-ETWIREKE 804
Query: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ---HEQLNEAAQGILTGPGDVSL- 3088
P++ N VQ +LK+ +A + + HE +A +T G+ +
Sbjct: 805 -------PIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKA----VTQKGNAMVE 852
Query: 3089 ----STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144
+ V+ +L +NQKW + L +++SQ Q + S Q Q+ D +E + +
Sbjct: 853 EGHFAAEDVKAKLHELNQKW----EALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
Query: 3145 RLSV--QSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
+ + + ++ + L++ + SDL ++ + + DE
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP--TDDE 966
Query: 3203 LKKRLETVALPLQGLEDLAADRINR----LQAALASTQQFQQMFDELRTWLDDKQSQQAK 3258
K L L L ++ + + + L ST + D + ++D+Q
Sbjct: 967 TGKEL---VLALYDYQEKSPREVTMKKGDILTLLNSTNK-----DWWKVEVNDRQG--FV 1016
Query: 3259 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLV 3318
KL+ QS +EN L + GS + + ++ Q+
Sbjct: 1017 PAAYVKKLDPAQSASREN------LLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVE 1070
Query: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQL 3378
EL + EL +K R+ L+ +K ++ +L WI + +A ++ V D Q+
Sbjct: 1071 ELYHSLLELGEK---RKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQV 1126
Query: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV---- 3434
E + +++ S L+ +N A+ + + +G+ E+ Q +
Sbjct: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAE------DLESEGLMAEEVQAVQQQEVYGMMP 1180
Query: 3435 TEELQAKT-----------------GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF- 3476
+E +KT S++E+ +R R Q+ + ++ G+ H+++ F
Sbjct: 1181 RDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFH 1239
Query: 3477 -------------------DALGSQACSNKNLE-KLRAQQEVLQALEPQVDYLRNFTQGL 3516
D G S + L+ K + L AL +V+ L + L
Sbjct: 1240 RDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERL 1299
Query: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA 3576
++ P+ AE Q++ E+ Q +S + + +G H ++ S
Sbjct: 1300 IQSHPE---------SAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH-DLQRFLSDFR 1349
Query: 3577 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA------ECRHMLEEE 3630
DL ++G+ + +D L + L + + +I+A + L
Sbjct: 1350 DLMSWINGIRGL-VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH 1408
Query: 3631 GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3690
G +K++L+ L+++ L + R+ L+ L ++ F+R + + AA EA
Sbjct: 1409 GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAEN-WMAAREA 1466
Query: 3691 EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE 3750
G ++ + + + F K ++ + K+ + LI A +
Sbjct: 1467 FLNTEDKGDSLDSVEALIKKHEDFDK-AINVQEEKIAALQAFADQLI--AAGHYAKGDIS 1523
Query: 3751 HDMEEINARWNTLNKKVAQRIAQLQEA--LLHCGKFQDALEPLLSWLADTEELIANQKPP 3808
E+ RW L ++ ++ ++L E+ L + D +E +S T + + P
Sbjct: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
Query: 3809 SAEYKVVKAQIQEQKLLQRLL----DDRKATVDMLQAEGGRIAQSAELADREKITGQLES 3864
+ + + ++ Q+ + + L D + +DM I + A + + +L +
Sbjct: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDM---GNSLIERGACAGSEDAVKARLAA 1640
Query: 3865 LESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKI 3924
L +W L+ K+A + ++L++ + F+ + +LS E LA SE G A +
Sbjct: 1641 LADQWQFLVQKSAEKSQKLKE-ANKQQNFNTGIKDFDFWLSEVEALLA-SEDYGKDLASV 1698
Query: 3925 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3984
+ +H+ LE DI H + SL + +S + + +K D++ R+ +I+
Sbjct: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQKIKSM 1757
Query: 3985 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH--ADHLA 4042
+ A L+++ F D + +W +++K V +D+ +D+ Q+ H
Sbjct: 1758 AASRRAKLNES-HRLHQFFRDMDDEESW---IKEKKLLVGSEDYGRDLTGVQNLRKKHKR 1813
Query: 4043 LNEEIVNRKKNVDQAIKNGQALLKQTT-GEEVLLIQEKLDGIKTRYADITVTSSKALRTL 4101
L E+ + + + G+ L T G+E IQ++L + ++ ++ + L
Sbjct: 1814 LEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE--IQQRLAQFVEHWKELKQLAAARGQRL 1871
Query: 4102 EQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRL 4161
E++ + +F + EE W+ E + L S T I ++ + + + H+
Sbjct: 1872 EESLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHK- 1928
Query: 4162 VLDTVNEVSRALLELVPW--RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
D VN+V +L+ E + + N + + QR ++D Q
Sbjct: 1929 --DRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN-SAFLQ 1985
Query: 4220 YEQAADAELAWVAETK---------RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKD 4270
+ AD +W+ E + R L ++ + +Q+ A LQ AF + I +
Sbjct: 1986 FNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ---AFQQEGIANIT 2042
Query: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330
++ + + E + L ++ L+ A E + + + L F
Sbjct: 2043 ALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFA 2102
Query: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390
+ + W E + P E+++ +E R S++ + ++L ++ Q
Sbjct: 2103 KKASAFNSWFENAEEDLTD-PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
Query: 4391 LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLET 4450
+K + E + +++ +++R L L + + E +DK+
Sbjct: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQ----EENDKLRQEFAQ 2217
Query: 4451 LENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL 4502
N + + + R + D E L+ EA KR+ +E+
Sbjct: 2218 HANAFHQW---------IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEI 2260
Score = 132 bits (331), Expect = 1e-29
Identities = 359/1935 (18%), Positives = 751/1935 (38%), Gaps = 265/1935 (13%)
Query: 1933 DLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFIS 1992
+L++WV K + + + D +L +Q+++ + ++ ++++DAL Q I
Sbjct: 584 ELKSWVNEK---MKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLI- 639
Query: 1993 EHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQN 2052
D++ ++ +NE+ ++ +LE T E + + QQ
Sbjct: 640 ----DVNHYAKDEVAARMNEVISLWKKLLEAT--------------ELKGIKLREANQQQ 681
Query: 2053 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN----QSDLKDLQDDIQNRATSF 2108
++ +ED+ W+ + E LA ++ LQK ++D+ QD I T
Sbjct: 682 QFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG-ITIQ 740
Query: 2109 ATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQ 2168
A +D F EN +++K +YEAL+E +++L +++ LQ
Sbjct: 741 ARQFQDAGHFDAEN-----------IKKKQEALVARYEALKEPMVARKQKLADSL--RLQ 787
Query: 2169 QETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTD 2228
Q + + K+ I AS +G
Sbjct: 788 QLFRDVEDEETWIREKEPI----------------------------AASTNRG-----K 814
Query: 2229 GYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ 2288
+GV +K +A E+ + TQ A +++ GH + ++
Sbjct: 815 DLIGVQNLLKK-------HQALQAEIAGHEPRIKAVTQKGNAMVEE-GHFAAED----VK 862
Query: 2289 QKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKEFESWLERSEKELENMHKG 2346
KL EL +++ A++ ++ Q L+D L Q++ D E ESW+ R ++ +
Sbjct: 863 AKLHELNQKWEALKAKAS---QRRQDLEDSLQAQQYFADANEAESWM-REKEPIVGSTDY 918
Query: 2347 GSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPS--EIGNLV 2404
G ++ +LLK+ + D+ ++ + Q + + S ++ P+ E G +
Sbjct: 919 GKDEDSAEALLKKHEALMSDLSAYGSSI-------QALREQAQSCRQQVAPTDDETGKEL 971
Query: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ-FQNSADSLQAWMQACEANVEKLLSD 2463
L D E+ + + G L +L ++ + Q ++ A A V+KL
Sbjct: 972 VLALYDYQEK--SPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA--AYVKKLDPA 1027
Query: 2464 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2523
AS +L+EQ + L++E ++Q + K G + + V+E S
Sbjct: 1028 QSASRENLLEEQGSIA--LRQEQIDNQTRITK----------EAGSVSLRMKQVEELYHS 1075
Query: 2524 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2583
+L + +R +L+K+ + +E+ E L Q I E E L ++V G
Sbjct: 1076 LLELGE-------KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV-----GAD 1122
Query: 2584 QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQL--- 2640
E + K D + + E+ + + + E +S +G +AE Q +Q
Sbjct: 1123 LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES------EGLMAEEVQAVQQQEVY 1176
Query: 2641 -CLQQQEKESSLKKLLPQAEMFEHLSG-------------KLQQFMENKSRMLASGNQPD 2686
+ + E +S A + H LQQ E +S++L S +
Sbjct: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH--- 1233
Query: 2687 QDITHFFQQIQELN--LEMEDQQENLDTLEHLVTELSSC-----GFALDLCQHQDRVQNL 2739
++ F + E +E ++Q N D H + + + GF DL D+V +L
Sbjct: 1234 -EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 1292
Query: 2740 RKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEK 2799
+ ++ ++ + A QE+ E + + K + + + + +L++
Sbjct: 1293 GE---TAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLG------DSHDLQR 1343
Query: 2800 QIEHLKSLLDDW-------ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVG 2852
+ + L+ W S L +++ LE T D++ T G
Sbjct: 1344 FLSDFRDLM-SWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402
Query: 2853 SSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
+ + Y + EI+ + ++ + L +R+ L L ++ H++
Sbjct: 1403 QQLLAHGHYAS----PEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQA 1457
Query: 2913 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2972
W+ ++E L + D S ++V+A + ++ F + KI + +A A L+
Sbjct: 1458 ENWMAAREAFLNTEDKGDS---LDSVEALIKKHEDFDKAINVQEEKIAAL-QAFADQLIA 1513
Query: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
+ + + + E L+ RW R + ++ +L ES + L F ++ W+ EK
Sbjct: 1514 AGHYAKGDISSRRNEVLD-RWRRLKAQMIEKRSKLGESQT-LQQFSRDVDEIEAWISEKL 1571
Query: 3033 LMM---GVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
P +I + L ++ Q+ Q E A + + + ++ G + S
Sbjct: 1572 QTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE-RGACAGS 1630
Query: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
V+ L ++ +W L K +S ++ +A K + ++D + V + L
Sbjct: 1631 EDAVKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEV-EALLAS 1688
Query: 3150 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209
+V L++ + +D+ + +K+ + D S++ + ++K + +T
Sbjct: 1689 EDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQAD--SLMTSSAFDTSQVKDKRDT 1746
Query: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
+ Q ++ +AA R +L + Q F+ M DE +W+ +K+ L +
Sbjct: 1747 INGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDE-ESWIKEKKLLVGSE-DYGRDLTGV 1804
Query: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
Q+ ++++ + L H + + ++ G+ L G+E+ +Q +L + HW+EL +
Sbjct: 1805 QNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE--IQQRLAQFVEHWKELKQ 1862
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAML 3389
A R RL++ ++ Q++ +VE+ WI + ++ ++ L + +A
Sbjct: 1863 LAAARGQRLEESLE-YQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFE 1921
Query: 3390 NEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMT 3449
+ + + + + LI + E+ I + G+N + + + + L+E +
Sbjct: 1922 TDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENS 1981
Query: 3450 QRLR-------------EFQESFKNIE-----KKVEGAKHQLEIFDALGSQACSNKNLEK 3491
L+ E + S K + V+ + E FDA G QA + +
Sbjct: 1982 AFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA-GLQAFQQEGIAN 2040
Query: 3492 LRAQQEVL--------QALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3542
+ A ++ L +A+E + ++ ++Q L A + + FL
Sbjct: 2041 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
Query: 3543 VKQRVNSGCVMMENKLEGI-GQFHCRVREMFSQLADLDD----ELDGMGAIGRDTDSLQS 3597
++ ++ EN E + C E L + D L A L
Sbjct: 2101 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2160
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK 3657
QI+ R+ N +EA E R+ L + +RELE L K+ + E K
Sbjct: 2161 QIKSFRVASNP--YTWFTMEALEETWRN-------LQKIIKERELE-LQKEQRRQEENDK 2210
Query: 3658 ARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKE 3717
RQE + + L D + EE+ L+ +++E + + +
Sbjct: 2211 LRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLE----SQLEATKR--------KHQ 2258
Query: 3718 QVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK---KVAQRIAQL 3774
++ ++ +L+++ LG + ++ D + EH + +W+ L++ ++ + Q
Sbjct: 2259 EIRAMRSQLKKIEDLGAAMEEAL--ILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQ 2316
Query: 3775 QEALLHCGKFQDALE 3789
+A G ++AL+
Sbjct: 2317 IQARNTTGVTEEALK 2331
Score = 95.9 bits (237), Expect = 1e-18
Identities = 332/1813 (18%), Positives = 689/1813 (38%), Gaps = 256/1813 (14%)
Query: 1817 LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEV 1876
L N++ K+ LE ++A QD + + R+ +D ++ ++ + ++++ + +
Sbjct: 710 LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEAL 769
Query: 1877 PAQLLKALEK--DAKNLQKSLSSVSD--TW-------------NSRLLHFQNAVEIEKTK 1919
++ +K D+ LQ+ V D TW L+ QN ++K +
Sbjct: 770 KEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNL--LKKHQ 827
Query: 1920 VLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQ 1979
L ++ G ++A N ++ +E L+ Q++E LK ++R+
Sbjct: 828 ALQ--AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQD 885
Query: 1980 LDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQME 2039
L+ Q+F + + ++ ++ + +D E + +AL L
Sbjct: 886 LEDSLQAQQYFADANEAESWMREKEPIVGSTD--YGKDEDSAEALLKKHEALMSDLSAYG 943
Query: 2040 QEALVKTLQKQQNTCHQQLEDLCSWVG-QAERALAGHQGRTTQQDLSALQKNQSDLKDLQ 2098
++ L++Q +C QQ+ G + AL +Q ++ ++ + + D+ L
Sbjct: 944 SS--IQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPRE----VTMKKGDILTLL 997
Query: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE----QYEALQEETRV 2154
+ + V D +GF+ K +A RE L + + + E + +TR+
Sbjct: 998 NSTNK--DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRI 1055
Query: 2155 AQ---------KELEEAVTSALQQETEKSKAAKELAENK----KKIDALLDWVTS--VGS 2199
+ K++EE S L+ EK K E + K ++ + L W+
Sbjct: 1056 TKEAGSVSLRMKQVEELYHSLLELG-EKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
Query: 2200 SGGQLLTNLPGMEQLSGA--SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 2257
+ ++ +L +E L +K +N+ E L+ E + A + + Q
Sbjct: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAEEVQAVQQ 1172
Query: 2258 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQ-------QKLGELKEQYSTSLAQSEAELK 2310
Q+ + + + + +P + L + EL E++ SL Q E
Sbjct: 1173 QEVYGMMPRD-----ETDSKTASPWKSARLMVHTVATFNSIKELNERWR-SLQQLAEERS 1226
Query: 2311 QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH 2370
Q+ E+Q+F +D E + W+E + L N G ++ +L ++ H
Sbjct: 1227 QLLGSAHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQRK----------H 1275
Query: 2371 KGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN 2430
+G R + G KV + G+ + + +D E+ T L+ + LG +
Sbjct: 1276 EGFERDLAALGDKVNSL------GETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRAD 1329
Query: 2431 M---LLGQYH---QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQE 2484
LG H +F + L +W+ V SD +A D + + L E
Sbjct: 1330 QRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS---SDELAKD-------VTGAEALLE 1379
Query: 2485 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2544
EH+ ++ + E G+ H H Q L ER+ L +
Sbjct: 1380 RHQEHRTEID-ARAGTFQAFEQFGQQLLAHGHYASPEIK-----QKLDILDQERADLEKA 1433
Query: 2545 AIAQSQSVQESLESLL--QSIGEVEQNLEGKQ--VSSLSSGVIQEALATNMKLKQDIARQ 2600
+ + + + LE L + + E + ++ +++ G +++ +K +D +
Sbjct: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDK- 1492
Query: 2601 KSSLEATREMVTRFMETADSTTAA------VLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2654
++ E + AD AA + + EV R+ +L Q EK S L +
Sbjct: 1493 --AINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE- 1549
Query: 2655 LPQAEMFEHLSGKLQQFMENKSRMLASGNQPD------QDITHFFQQIQELNLEME---D 2705
+ F +++ ++ K + + + D + Q+ Q E+ D
Sbjct: 1550 SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANAD 1609
Query: 2706 QQENLDTLEHLVTELSSCGFALD-----LCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
+ + + + + E +C + D L D+ Q L + E + +KE K
Sbjct: 1610 RIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ---- 1665
Query: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
F ++ F WL E E +++++ K + + +LL K L+E
Sbjct: 1666 ----QNFNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLL----KKHQLLE- 1709
Query: 2821 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2880
+I+A + + K L S S+ + + + D ++++ +N +
Sbjct: 1710 ------------ADISAHEDRLKD---LNSQADSLMTSSAF----DTSQVKDKRDTINGR 1750
Query: 2881 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2940
++K+ + R+ L +R+ + ++ + W++ K+ ++ S D T + ++
Sbjct: 1751 FQKIKSMAASRRAKLNE-SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR- 1808
Query: 2941 QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT 3000
+ +K AEL + P IQ V + G ++ N+ E ++ + W+ ++
Sbjct: 1809 --KKHKRLEAELAAHEPAIQGVLD--TGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLA 1864
Query: 3001 VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK 3060
AR ++LEES + F A + W+ EK ++ S D A +Q +LK
Sbjct: 1865 AARGQRLEESLEYQQ-FVANVEEEEAWINEKMTLVA-----SEDYGDTLA---AIQGLLK 1915
Query: 3061 EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 3120
+ EA + + T D+ + ++ + S LN + S +++
Sbjct: 1916 KHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISS-------KMKGLNGKVSDLEK 1968
Query: 3121 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180
A + Q + L + S ++ + V+S I + ++K T + DL + +
Sbjct: 1969 A---AAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-----TDDYGRDLSSVQTLL 2020
Query: 3181 KEAQTLCDELSVLIGE-----QYLKDEL--KKRLETVALP------LQGLEDLAADRINR 3227
+ +T L E LKD+L K +++ A+ ++ L A+ R
Sbjct: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
Query: 3228 LQAALASTQQFQQMFDELRTWLDD--------KQSQQAKNCPISA-KLERLQSQLQENEE 3278
+ L + F+++ D T+ + +++ P+ LE +++ + ++
Sbjct: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
Query: 3279 FQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR---- 3334
F+ SL+ + + AE + + S T + L+ W L K +R
Sbjct: 2141 FRSSLSSAQADFNQL-AELDRQIKSFRVASNPYTWFT-MEALEETWRNLQKIIKERELEL 2198
Query: 3335 ---QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAMLN 3390
Q R ++ + Q++ H WI++ + + + ++ LES L +K
Sbjct: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA-----------VTEELQ 3439
E+ RS L+ + + + D G+ Q D + +++Q
Sbjct: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2318
Query: 3440 AK--TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQE 3497
A+ TG EE L+EF FK+ +K G + E L S +E+ E
Sbjct: 2319 ARNTTGVTEE---ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPE 2375
Query: 3498 ---VLQALEPQVD 3507
+L ++P D
Sbjct: 2376 FEAILDTVDPNRD 2388
Score = 70.9 bits (172), Expect = 4e-11
Identities = 91/435 (20%), Positives = 178/435 (40%), Gaps = 37/435 (8%)
Query: 5170 EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLA 5229
E ++ + +V D++ S R+ KLE++ F DA + L W+ + + Q+A
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIA 67
Query: 5230 EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 5289
D+ +L + H+ F+ E+ +G + L +G +I + ++ +L E
Sbjct: 68 SDENYKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLME 126
Query: 5290 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 5349
L +W+ + + K +L QA K + R+ ++ +W+++ E + L D E +
Sbjct: 127 LHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVM-DWINDKEAIVTSE-ELGQDLEHV 184
Query: 5350 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW 5409
+ L +EF + VN ++ HP+ IK + A ++ +
Sbjct: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGL 243
Query: 5410 AKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQT 5469
A Q Q +L A N ++ +E ++WI+ E + D +++ V+AL+ +H+
Sbjct: 244 ALQRQGKLFGAAEVQRFNRDV-DETISWIKEKEQLMASDD---FGRDLASVQALLRKHEG 299
Query: 5470 FMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK 5529
++ + V + R L Q P LS ++ +
Sbjct: 300 LERDLAALEDKVKALCAEADR---------------------LQQSHP-----LSATQIQ 333
Query: 5530 NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSR 5589
R +L W+Q+ LA ER +LND+ L +F + V K + + S
Sbjct: 334 VKR-EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASD 392
Query: 5590 VMDFFRRIDKDQDGK 5604
V +D+ Q+ K
Sbjct: 393 VAGAEALLDRHQEHK 407
>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
Length = 2341
Score = 249 bits (635), Expect = 8e-65
Identities = 337/1747 (19%), Positives = 735/1747 (42%), Gaps = 180/1747 (10%)
Query: 3675 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3734
R+ K L + +A+E E ++ + I++QLA + ++VD QM +
Sbjct: 16 RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA---AYIADKVDAAQMPQEAQK---- 68
Query: 3735 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA--------QLQEALLHC----- 3781
IQS D+ E +EE+ + K+ AQR+ +LQ+ +
Sbjct: 69 --IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQK 119
Query: 3782 -GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
F+ L+ L + + + + S E +VV++Q+ L + L + K+ V+M+
Sbjct: 120 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 179
Query: 3841 AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI 3900
G +I Q + + +++ ++ +L+ + EL +K R++QLE L L+++ + +
Sbjct: 180 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 239
Query: 3901 SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3960
+++L+ T+ +L V + + ++ KA +++IE + ++G++L ++
Sbjct: 240 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 299
Query: 3961 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 4020
E ++ +K+ L + + + R LL + + F ++ + W+ + + L
Sbjct: 300 KKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 358
Query: 4021 SSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQE 4078
K K+DVL R L E+ + + VD L+ L++
Sbjct: 359 DESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEP 411
Query: 4079 KLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYEELTGWLRE---VEEELATSG 4133
++ + R+A I+ + + KA L++ Q + Q E L +++ ++EE
Sbjct: 412 QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD 471
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVNEVSRALLELVPWRAREGLDK 4187
+ + QR L++ + + R + + AL +L R ++ L+
Sbjct: 472 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALE- 530
Query: 4188 LVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQAADAELAWVAETKRKLMALG 4242
+S QYK +D + + +D+I+ + R ++ + D EL ++K L
Sbjct: 531 -ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDREL------QKKKEELN 583
Query: 4243 PIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 4299
+R + + + A + V+ I + + ++ F+ F Q ++E+T
Sbjct: 584 AVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ----FRRLNFAQIHTVREETM 638
Query: 4300 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQ 4359
++ + + + + + + +S + E L+ A D E
Sbjct: 639 MVMTEDMPLEI------------SYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 686
Query: 4360 LRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418
L +Q+E ++ +++S+ + ID + K L+ P E ++E + + + ++ +
Sbjct: 687 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 746
Query: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA--EVDKIRECIS 4476
+ R D +V + + FH I+ + L LR IP E K + +
Sbjct: 747 MYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFLRKTQ-IPENWEHAKYKWYLK 802
Query: 4477 DNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4536
+ + + + Q L GEE+I +S D + +Q+KL + W+++ +
Sbjct: 803 ELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQL 855
Query: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4596
+R+ + + + +F D+ + +++ +I PG + + K+++E + + E
Sbjct: 856 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVE 914
Query: 4597 ETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654
E L+ + G ++ + E+ ++ + + N W +++ E+ ++E
Sbjct: 915 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 974
Query: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE----MKEFKVEVYQQ 4710
++ Q + L+ + + L++ ++ L P+ L E ++E ++ V +
Sbjct: 975 QIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
Query: 4711 QIEMEKLNHQGELMLKK--ATDETDRDI---------IREPLTELKHLWENLG------- 4752
Q ++E++ +G+ + K+ AT R + + L EL+ +L
Sbjct: 1032 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1091
Query: 4753 ----------------EKIAHRQHKLEGALL----ALGQFQHALEELMSWLTHTEELLDA 4792
++ A + ++ +L+ AL F A EL WL+ ++++ +
Sbjct: 1092 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1151
Query: 4793 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASS-LRSRLE 4851
QR + GD + I + K D+ + +E + A L ++ +A + + R+E
Sbjct: 1152 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1211
Query: 4852 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPET 4911
+ W+ V + + R QQL L+ + + E+ L + ++L + K +
Sbjct: 1212 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1271
Query: 4912 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVS 4971
++++ +L L+ + +T + + L LL + K + W +
Sbjct: 1272 IQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
Query: 4972 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI---ASPPSLILNT---VLSQ 5025
++ ER++ LEE L +F L++F+ WLT AE + N+ A+ +L V
Sbjct: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
Query: 5026 IEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 5084
+++ + E+ AH D LD+ + L+ L D VL++ L ++ +W ++ ++S+
Sbjct: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
Query: 5085 ERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKT 5144
L+ + + K+ H + ++L+ WL+ + L + I D ++ Q H+ F++
Sbjct: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
Query: 5145 LGGKQPVYDTTIRTGRAL--------------KEKTLLPED-SQKLDNFL----GEVRDK 5185
L K+PV +T+ T R + + L PE+ +Q + L EV +
Sbjct: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
Query: 5186 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL--DLVMN 5243
W+ + S + Q K++E L + +A L L + E QPV GDL D + +
Sbjct: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQD 1629
Query: 5244 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 5303
++ K + E+ V + R+L + + L++L+TRW L V+
Sbjct: 1630 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL---LQVA 1686
Query: 5304 KQSRLEQ 5310
+ R+ Q
Sbjct: 1687 VEDRVRQ 1693
Score = 218 bits (555), Expect = 1e-55
Identities = 319/1672 (19%), Positives = 678/1672 (40%), Gaps = 176/1672 (10%)
Query: 3984 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 4043
+ R+ LL+Q++ +A+ E + ++ DK + ++ D Q A +
Sbjct: 13 KAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI-- 69
Query: 4044 NEEIVNRKKNVDQAIKNGQAL-LKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE 4102
++ + + ++++ K+ Q Q ++ + Q+KL + ++
Sbjct: 70 QSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF--------------- 114
Query: 4103 QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLV 4162
+ Q F+ +E L EV+ L +S E + L K + E +
Sbjct: 115 RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSE 174
Query: 4163 LDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 4222
++ V + R +++ + LD+ V+ Y + + +R +++ ++ S++ +
Sbjct: 175 VEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRK 234
Query: 4223 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 4282
+ W+A T +L + +++ KA +I + K + + +E+
Sbjct: 235 EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV 290
Query: 4283 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW--- 4339
GE KTVL +K E+L++ + +SLLNS A RA+ +N E + + +
Sbjct: 291 ----GEALKTVLGKK-ETLVE--DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
Query: 4340 IEETRALIAQLPSPAIDHEQLRQQQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPE 4397
++ I Q + + E+ + QQ+E +++L+ + + +P +D Q L
Sbjct: 344 VDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMAN 400
Query: 4398 EGE----MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE- 4452
G+ +VE + + + +A I ++ +A ++ +F+ I+ +LE LE
Sbjct: 401 RGDHCRKLVEPQISELNHRFAAISHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEA 455
Query: 4453 NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512
+ + + E D ++ DN+ EL +RG+ L Q +
Sbjct: 456 EIQQGVNLK-----EEDFNKDMNEDNEGTVKEL----------LQRGDNL---QQRITDE 497
Query: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
+EI+ K + +K +R K L++ ++ LL + D + +
Sbjct: 498 RKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLA 557
Query: 4573 DLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSID 4632
L P D IK+ + KEE + + + E + GA + + + + + I+
Sbjct: 558 SLPEPR-DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIE 616
Query: 4633 EMNNAWENLN-----KTWKERLEKLEDAMQAAVQYQDTL---------QAMFDWLDNTVI 4678
+ LN +E + + + M + Y + QA+ + V
Sbjct: 617 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE-----VE 671
Query: 4679 KLCTMPPV-GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDII 4737
+L P + D + Q +K K + Q ++ ++ + L+ AT +R +
Sbjct: 672 QLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKL 730
Query: 4738 REPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPI 4796
+E L++L WE + + RQ + + ++ +F + ++ WLT E+ L Q P
Sbjct: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790
Query: 4797 SGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQC 4856
+ + + L + L++ + Q V T+N G E+++ S+ DAS L+ +L ++N
Sbjct: 791 NWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLR 847
Query: 4857 WESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL 4916
W+ V ++ +R+++L+ F ++ +F+L L ++ +++ G + +E+L
Sbjct: 848 WQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKL 906
Query: 4917 DTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDS-GSGSKTEQSVALLEQKWHVVSSKME 4975
+ L +L ++ QL + G +L+S S K E + +W VS +
Sbjct: 907 EQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALP 966
Query: 4976 ERKSKLEEALNLATEFQNSLQE-------FINWLTLAEQSLNIASPPSLILNTVLSQIEE 5028
E++ ++E + + + L++ + WL+ L I + P+ ++E
Sbjct: 967 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQE 1023
Query: 5029 HKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ------- 5081
++ V A + + E+ G L +K +K L + S W+ V +
Sbjct: 1024 TEI---AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 1078
Query: 5082 ----------------------------------RSIERGRSLDDARKRAKQFHEAWKKL 5107
+E SL F+ AW +L
Sbjct: 1079 KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTEL 1138
Query: 5108 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 5167
DWL + + S+ + D + I + K K + L ++P + I + LK KT
Sbjct: 1139 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 1198
Query: 5168 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ 5227
E + + + ++++WD V R+ +L E L S Q+++A + L + +
Sbjct: 1199 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 1258
Query: 5228 LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQ 5286
L + +D + + K K+L + V V +L+ + S DDT V
Sbjct: 1259 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 1318
Query: 5287 LQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT 5346
+ ++ W ++ K +++ LE+ + + F + L WL+EAE T L D T
Sbjct: 1319 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDAT 1375
Query: 5347 EALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPDCITTIKHWI 5396
+ L D+ KE MK+ ++ + ++ + + +++ ++ D ++ +
Sbjct: 1376 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 1435
Query: 5397 TIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQN 5456
+ ++ E+ + + LE + + L+ELL W+Q + L + Q PI +
Sbjct: 1436 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGD 1493
Query: 5457 IDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP- 5515
V+ H+ F E+ K+P + +E E+ G K +P
Sbjct: 1494 FPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEGLEKLYQEPR 1545
Query: 5516 -TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566
PP + + + +++ W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 1546 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1597
Score = 211 bits (538), Expect = 1e-53
Identities = 284/1603 (17%), Positives = 653/1603 (40%), Gaps = 161/1603 (10%)
Query: 3872 LLSKAAARQKQLEDILVLAKQFHETA------EPISDFLSVTEKKLANSEPVGTQTAKIQ 3925
+LS+ QK+L+D+ + + F + A + L + L E + +Q
Sbjct: 96 VLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQ 155
Query: 3926 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3985
Q+ L + + ++V +K G+ + L E++ +L+ Y+E+ +
Sbjct: 156 SQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV 215
Query: 3986 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 4045
+ L++ L +R ++ + WLA + +L+ + L + A A +
Sbjct: 216 TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK 275
Query: 4046 EIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 4105
EI +K ++ + G+AL K G++ L+++KL + + + +T + + L L + +
Sbjct: 276 EIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 334
Query: 4106 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 4165
+ F + +T W+ + + L S + P Q + K LK E+ + R +D+
Sbjct: 335 KHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-----QKEDVLKRLKAELNDIRPKVDS 389
Query: 4166 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 4225
+ + L+ R+ ++ +S+ N ++ +S I + + ++ +Q+ +
Sbjct: 390 TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQF----N 443
Query: 4226 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285
+++ + E + G E+D + + ++++ D++ + +
Sbjct: 444 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD------- 496
Query: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
E ++ ++ K + L ++ A+ L S+R + Q+ ++L +++
Sbjct: 497 --ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 554
Query: 4346 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 4405
+A LP P D ++++ E+++ +E + + + L + G + + P + ++ ++
Sbjct: 555 KLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKR 611
Query: 4406 YQKAENMYAQ-----------IKEE---VRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
+++ E+ +AQ ++EE V + L+ + ST +TE + +LE
Sbjct: 612 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 671
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
+ L++ P L + + + + K+ L++ + + + + + ++
Sbjct: 672 QLLNA----PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 727
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
++Q+ L Q+ F WE + ++R+ +F +E +F YD+ + + + +
Sbjct: 728 ----VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL 783
Query: 4572 HDLESPGIDPSIIKQQVEAAET---IKEETDGLHEELEFIRIL---GADLIFACGETEKP 4625
+ P + E A+ +KE DG+ + +R L G ++I +T+
Sbjct: 784 RKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDAS 835
Query: 4626 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685
+++ + +N W+ + K +R ++LE+ ++Q L WL+ + ++P
Sbjct: 836 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPL 894
Query: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT-DETDRDIIREPLTEL 4744
+K++L ++K E+ +Q +++LN G +L A ++D + L +
Sbjct: 895 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 954
Query: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEEL-------MSWLTHTEELLDA--QRP 4795
W + + +Q ++E + LGQ + LE+L + WL+ L+ Q
Sbjct: 955 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 1014
Query: 4796 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855
G V E E+A V A Q VE + G L + ++ +LE ++
Sbjct: 1015 QEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPA--TQPVKRKLEDLSS 1064
Query: 4856 CWESV---LQKTEEREQQLQSTLQQAQGFHSEI----------EDFLLELTRMESQLSAS 4902
W++V LQ+ ++ L L ++ ++ + M S L
Sbjct: 1065 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1124
Query: 4903 KPTGGLPETAREQLDTHMELYSQLKAKE-------ETYNQLLDKGRLML----------- 4944
P A +L + L Q+ + E N+++ K + +
Sbjct: 1125 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1184
Query: 4945 --------LSRDDSGSGSKT--EQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4994
L S ++T + ++ +W V ++ R+ +L E L +T++ +
Sbjct: 1185 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1244
Query: 4995 LQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLK 5054
+E L A L ++ + +I E K A ++ + + + +L
Sbjct: 1245 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1304
Query: 5055 FLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDA 5114
D + + ++ + W + +R ER +L++ + +QF +K + WL +A
Sbjct: 1305 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1364
Query: 5115 ESHLD------SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLL 5168
E+ + + + D +K + + ++ Q + VY + +
Sbjct: 1365 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG 1424
Query: 5169 PEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL 5228
+D+ L L + KW + KS+ + LE + + +LQ L+ WL + +L
Sbjct: 1425 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 1484
Query: 5229 AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV-------------------QVLKRSG 5269
+ P+ GD V D H+ F++EL + + + L +
Sbjct: 1485 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1544
Query: 5270 RELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
REL E +++ T ++ Q +E++T W+ + S Q ++++ L++ + ++ L
Sbjct: 1545 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1604
Query: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
L +AE + D LID+ ++ ++KV+ R ++
Sbjct: 1605 KLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1641
Score = 209 bits (531), Expect = 9e-53
Identities = 336/1819 (18%), Positives = 737/1819 (40%), Gaps = 202/1819 (11%)
Query: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504
LE+ Q +E ++S I++ + QL + + + + + ++ + Q L + E
Sbjct: 21 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEI 78
Query: 3505 QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564
++ ++ QG A ++L Q +VAQ++ +V + + F
Sbjct: 79 SLEEMKKHNQGK-------EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANF 123
Query: 3565 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3624
R++E L ++ L + + + +QSQ+ + +K ++E R
Sbjct: 124 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 183
Query: 3625 HMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684
+++++ T + L + AL +L + R++QLE L +++ L +
Sbjct: 184 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 243
Query: 3685 TAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC 3744
A + + V ++ ++A K QKE ++ ++ L+ + +G+ L GK
Sbjct: 244 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKE 302
Query: 3745 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-- 3802
+ +E + +N+ W + + + + L E H F ++ + W+ + L+
Sbjct: 303 TL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 360
Query: 3803 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3862
+ +K P + V+K L+ L+D + VD + + + + R+ + Q+
Sbjct: 361 SEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 413
Query: 3863 ESLESRWTEL-----LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917
L R+ + KA+ K+LE F S +K L EP+
Sbjct: 414 SELNHRFAAISHRIKTGKASIPLKELEQ-----------------FNSDIQKLL---EPL 453
Query: 3918 GTQTAKIQQQI-IRHKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSL 3974
A+IQQ + ++ + +D+ E++ V + ++ G +L +T ++ + K L
Sbjct: 454 ---EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLL 510
Query: 3975 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKD 4027
Q +++ ++D ++ + + ++L L ++E KL+S+ +K+
Sbjct: 511 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 570
Query: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI---- 4083
+++ ++ EE+ ++ + ++G A+ + T ++ +++
Sbjct: 571 IDRELQKKK--------EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 622
Query: 4084 -KTRYADITVTSSKALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSP 4137
+ +A I + + + + L + STY ++ L EVE+ L +
Sbjct: 623 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 682
Query: 4138 TGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 4197
E + + ++ K +K + + +D ++ A L+ R L + +S + Q++
Sbjct: 683 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 742
Query: 4198 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ- 4256
V+ R D ++++ +++ W+ E ++ L ++ ++ A+ +
Sbjct: 743 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKW 799
Query: 4257 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 4316
K I + + + L + EI + ++LQEK SL +++ + S+R
Sbjct: 800 YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 859
Query: 4317 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 4376
RLE + ++++F E W+EE IA +P +QL+++ E+++ L E +
Sbjct: 860 KRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPL 918
Query: 4377 HKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 4433
+ + +L + G + ++PEE + +E K ++ + ++ + ++ E +Q
Sbjct: 919 RQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQ 975
Query: 4434 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 4493
+ + K+E + E L +L L + P+ +++ N+ ++++ + + +
Sbjct: 976 IKDLGQLEKKLEDLEEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQ 1029
Query: 4494 ALKRRGEELIGRSQGADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEK 4552
A + EE++ + Q K+ A + ++ KL+ + W+ + +E K
Sbjct: 1030 AKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---------- 1079
Query: 4553 FWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG 4612
D+A LTTI SP +++ Q V ET
Sbjct: 1080 -QPDLAPGLTTIG---------ASPTQTVTLVTQPVVTKETA------------------ 1111
Query: 4613 ADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4672
K E+ S+ A + N+ W E + DW
Sbjct: 1112 ---------ISKLEMPSSLMLEVPALADFNRAWTE---------------------LTDW 1141
Query: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4732
L + + + DL + + + + K ++ Q++ ++E+L + + K +++
Sbjct: 1142 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1201
Query: 4733 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4792
R II + + +++ W+ + E + +R+ +L L Q+ A EE L L++
Sbjct: 1202 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 1261
Query: 4793 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEA 4852
+ I+ ++ + L D+ Q V+ N +LL + DD + E
Sbjct: 1262 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 1321
Query: 4853 MNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGL 4908
+N W S+ ++ ERE L+ T + Q F ++E FL LT E+ + A++ L
Sbjct: 1322 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 1381
Query: 4909 PET--AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4966
++ +E + +L +++A + Y+ L + + +L S + S ++ + + K
Sbjct: 1382 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1441
Query: 4967 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 5026
W + K +S LE + + SLQE + WL L + L+ +P V Q
Sbjct: 1442 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1501
Query: 5027 EEHKVFANEVNAHRDQII-------------------ELDQTGNQLKFLSQKQDVV-LIK 5066
+ H+ F E+ I+ +L Q +L + Q+V L++
Sbjct: 1502 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1561
Query: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
V + WEK+ S + R +D+ +R ++ EA +L L AE S +
Sbjct: 1562 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG- 1620
Query: 5127 DPDKIKLQLSKHKEFQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRD 5184
D + L H E K L G+ P+ + ++ T L + + L ++
Sbjct: 1621 --DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNT 1678
Query: 5185 KWDTVCGKSVERQHKLEEA 5203
+W + +R +L EA
Sbjct: 1679 RWKLLQVAVEDRVRQLHEA 1697
Score = 155 bits (393), Expect = 9e-37
Identities = 297/1513 (19%), Positives = 615/1513 (40%), Gaps = 181/1513 (11%)
Query: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
+T + + V+Q QL L + L+E + VE + K R I++ + P + + E
Sbjct: 145 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENP--KELDERVT 202
Query: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
++ H+ L + ER L+K + S+ +++ + L + + + L +
Sbjct: 203 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 262
Query: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCL 2642
+ +A +++I +QK L++ E V ++T +++ KL+ ++
Sbjct: 263 LDSEVAWGKATQKEIEKQKVHLKSITE-VGEALKTVLGKKETLVEDKLSLLN-------- 313
Query: 2643 QQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL- 2701
S+ + +AE + +L + Q+ ME DQ++ H + I + +
Sbjct: 314 ------SNWIAVTSRAEEWLNLLLEYQKHMETF----------DQNVDHITKWIIQADTL 357
Query: 2702 ----EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2757
E + Q+ D L+ L EL+ +D +D+ NL + + + + E
Sbjct: 358 LDESEKKKPQQKEDVLKRLKAELNDIRPKVD--STRDQAANLMANRGDHCRKLVE----- 410
Query: 2758 SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL 2817
Q+ E +K + SIP E +++K +E L++ +
Sbjct: 411 ----PQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA---------EI 457
Query: 2818 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2877
+ +N K + E D++G +L + + + EI+ +
Sbjct: 458 QQGVNLKEEDFNKDMNE----DNEGTVKELLQRGDNLQQRITDE---RKREEIKIKQQLL 510
Query: 2878 NLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET 2937
K+ L + +R++ I ++ + ++A+ +L+ L+ E+ L S+ K +
Sbjct: 511 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 570
Query: 2938 VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERAT 2997
+ + + K EL + + + E A + V Q ++ W++I+ + +++ R
Sbjct: 571 IDRELQKKK---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF-AQFRRLN 626
Query: 2998 EVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQF 3057
+ R EE+ + E P E+ L ++ +LNA
Sbjct: 627 FAQIHTVR--EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE-QLLNAP----DL 679
Query: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ-KWVELTDKLNSRSS 3116
K+FE +Q E L + G + + S+ LQS + V+L + L+
Sbjct: 680 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 739
Query: 3117 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE-----ETSEIRS 3171
Q ++ Q EK R + + + T+ E ++ + E ++ +
Sbjct: 740 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 799
Query: 3172 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-------LKKRLETVALPLQGLEDLAADR 3224
L++L + + QT+ L+ GE+ ++ L+++L ++ L Q + +DR
Sbjct: 800 YLKELQDGIGQRQTVVRTLNA-TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 858
Query: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPIS-AKLERLQSQLQENEEFQKSL 3283
RL+ +FQ+ +E WL+ ++ + P+ K ++L+ +L++ + + L
Sbjct: 859 KKRLEEQKNILSEFQRDLNEFVLWLE--EADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 916
Query: 3284 NQHSGSYEVIVAEGESLLLSVP-PGEEKRTLQNQLVELKNHWEELSKKTADRQ----SRL 3338
G + + G +L+S P EE+ L+N+L + W ++S+ ++Q +++
Sbjct: 917 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 976
Query: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 3398
KD Q +K +ED + +++ L + L P+ R+
Sbjct: 977 KDLGQLEKK-----------LEDLEEQLNHLLLWLSPI-------------------RNQ 1006
Query: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
LEI N + +++G D + + AV QAK +EE+ L + Q
Sbjct: 1007 LEIYN----------QPNQEGPFD----VQETEIAV----QAKQPDVEEI---LSKGQHL 1045
Query: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
+K + + K +LE D N+ L++LRA+Q L + T LV
Sbjct: 1046 YKE-KPATQPVKRKLE--DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1102
Query: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRV--NSGCVMMENKLEGIGQFHCRVREMFSQLA 3576
+ + + + E+ LEV N + + L + Q R M L
Sbjct: 1103 QPVVTKETA--ISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 1160
Query: 3577 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL 3636
D+++ + A +D + + Q+E++ L + S E R ++ +
Sbjct: 1161 DINEMIIKQKATMQDLEQRRPQLEELITAAQ-----NLKNKTSNQEARTIITD------- 1208
Query: 3637 GLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL--Q 3694
+E + Q ++ E + R++QL L +D + L+ +A +A A
Sbjct: 1209 ----RIERIQNQWDEVQEHLQNRRQQLNEML---KDSTQWLEAKEEAEQVLGQARAKLES 1261
Query: 3695 WVVGT-EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753
W G V+ I +++ + K K+ + Q + N L L++ D D + +
Sbjct: 1262 WKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYSAD-DTRKVHMIT 1319
Query: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-----ANQKPP 3808
E INA W +++K+V++R A L+E +F LE L+WL + E A +K
Sbjct: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
Query: 3809 SAE-YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA-DREKITGQLESLE 3866
E K VK +++ + LQ ++ L +I +S E + D + +L+++
Sbjct: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
Query: 3867 SRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 3926
+W+EL K+ + LE K+ H + + + +L + + +L+ P+G +Q+
Sbjct: 1440 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQK 1499
Query: 3927 QIIRHKALEEDIE 3939
Q H+A + +++
Sbjct: 1500 QNDVHRAFKRELK 1512
Score = 139 bits (349), Expect = 1e-31
Identities = 282/1654 (17%), Positives = 682/1654 (41%), Gaps = 187/1654 (11%)
Query: 2892 QESLQAILNRMEEVHKEANSVLQWLESK---EEVLKSMDAMSSPT-KTETVKAQAESNKA 2947
Q+ LQ + + K AN + ESK +EV + A+ + + + E V++Q
Sbjct: 104 QKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVN 163
Query: 2948 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV---TVARQ 3004
L + +++ V + ++ ++ EN K++ E + + E+ R+
Sbjct: 164 LYKSLSEVKSEVEMVIKTGRQIV----QKKQTENPKELDERVTALKLHYNELGAKVTERK 219
Query: 3005 RQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEA 3064
+QLE+ + + L WL ++ + + P+ L+++ + KE E
Sbjct: 220 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 279
Query: 3065 RRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK 3124
++ + + E + + T G + V+ +L +N W+ +T S+ ++ +
Sbjct: 280 QKVHLKSITEVGEALKTVLGK---KETLVEDKLSLLNSNWIAVT-------SRAEEWLNL 329
Query: 3125 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET--SEIRSDLEQLDHEVKE 3182
+YQ+ ++ + V + + + + + E K Q +E ++++L + +V
Sbjct: 330 LLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS 389
Query: 3183 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 3242
+ L G D +K +E L + RI +A++ ++ +Q
Sbjct: 390 TRDQAANLMANRG-----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFN 443
Query: 3243 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ-HSGSYEVIVAEGESLL 3301
+++ L+ P+ A+++ Q + E+F K +N+ + G+ + ++ G++L
Sbjct: 444 SDIQKLLE----------PLEAEIQ--QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 491
Query: 3302 LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
+ ++ ++ + L+ L + R+ + + + +Y+ +DL+ ++D
Sbjct: 492 QRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDD 551
Query: 3362 CKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 3418
+ K++ L D +++ L + K LN V ++ L +A + + +
Sbjct: 552 IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKR 611
Query: 3419 G--IRDEKAGINQNMDAVTEELQAKTGSL--EEMTQRLREFQESFKNIEKKVEGAKHQLE 3474
I + A + A ++ +T + E+M + ++ V A LE
Sbjct: 612 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL--LE 669
Query: 3475 IFDALGSQACSNKNLEKLRAQQEVLQALEP-------QVDYLRNFTQGLVEDAPDGSDAS 3527
+ L + K+ E L Q+E L+ ++ ++D + + ++ A +
Sbjct: 670 VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA---TPVE 726
Query: 3528 QLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3585
++ Q ++Q +F +V + + +E +FH ++ +F+Q ++
Sbjct: 727 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK-IFNQWLTEAEQFLRK 785
Query: 3586 GAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELE 3643
I + + + + +++++ + + + + A+ E ++++ D L+ +L
Sbjct: 786 TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEE---IIQQSSKTDASILQEKLG 842
Query: 3644 ALNKQ----CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV-- 3697
+LN + C +L++R K +EQ + + +F R L N+ EEA+ + +
Sbjct: 843 SLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQRDL---NEFVLWLEEADNIASIPLE 895
Query: 3698 -GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVNGLGQGLIQSAGKDCDVQG-LEHDME 3754
G E ++ ++L K+ +E PL+ L+Q+N G ++ SA + Q LE+ ++
Sbjct: 896 PGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK 952
Query: 3755 EINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL-------LSWLADTEELIANQKP 3807
+ N +W +++ + ++ +++ + G+ + LE L L WL+ +
Sbjct: 953 QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1012
Query: 3808 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3867
P+ E +QE ++ + ++ V+ + ++G + + E + + +LE L S
Sbjct: 1013 PNQEGPF---DVQETEIA---VQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSS 1064
Query: 3868 RW---TELLSKAAARQKQLEDIL-----------------VLAKQ--------------- 3892
W LL + A+Q L L V+ K+
Sbjct: 1065 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1124
Query: 3893 ------FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946
F+ ++D+LS+ ++ + + + I + II+ KA +D+E +
Sbjct: 1125 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1184
Query: 3947 QAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED 4005
+ + Q+L + TS E + +++++I+ +Q ++ E+Q+ + L++ L ++ + E
Sbjct: 1185 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1244
Query: 4006 EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL 4065
+ E L + KL S + D + ++ + L +++ + NVD A LL
Sbjct: 1245 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1304
Query: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
+ + ++ + + I + I S+ LE+ +L +F E+ WL E
Sbjct: 1305 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1364
Query: 4126 E------EELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 4179
E ++ + + + ++ ++L+ E+ H V ++E S+ +L
Sbjct: 1365 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL----- 1419
Query: 4180 RAREGLDKLV------SDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAE 4233
R+ EG D V + N ++ + ++A+ + ++ + L W+
Sbjct: 1420 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 1479
Query: 4234 TKRKLMALGPIRLEQDQTTAQLQVQKAF-------------SIDIIR------HKDSMDE 4274
+L PI + Q V +AF +++ +R + +++
Sbjct: 1480 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 1539
Query: 4275 LFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
L+ E+ + T +L+++ E + ++E ++L +++ +++ + + E
Sbjct: 1540 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 1599
Query: 4334 EELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK 4392
+EL + + + P + + L+ E+++ LR IA K ++ + + QL
Sbjct: 1600 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1659
Query: 4393 ----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
+L+P +E+ + + + +++ VRQ
Sbjct: 1660 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1693
Score = 120 bits (300), Expect = 5e-26
Identities = 252/1367 (18%), Positives = 508/1367 (37%), Gaps = 188/1367 (13%)
Query: 1843 QAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTW 1902
+A + +EL+ + + + LE + I K + +D + K L D
Sbjct: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
Query: 1903 NSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC 1962
R+ + EI+ + L Q L+DLR+ K L ++ + + D L C
Sbjct: 491 QQRITDERKREEIKIKQQLLQTKH--NALKDLRSQRRKKALEISHQWYQYKRQADDLLKC 548
Query: 1963 LQQYE----DLKQPMAERKA------------QLDALAFDIQFFISEHAQDLSPQQNRQM 2006
L E L +P ERK +L+A+ + + A Q+
Sbjct: 549 LDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 608
Query: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVG 2066
+ E++ F AQ+ ++ + E + + +T ++ + +
Sbjct: 609 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 668
Query: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126
+ E+ L +D L K + LK+++D +Q + + ++
Sbjct: 669 EVEQLLNAPD--LCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQS----A 722
Query: 2127 SPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKK 2186
+P E L+E L Q Q+E + + + Q + +V + +
Sbjct: 723 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD-------------- 768
Query: 2187 IDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEM 2246
I W+T + ++ Q PE +
Sbjct: 769 IKIFNQWLTEA------------------------------EQFLRKTQIPENWEH---- 794
Query: 2247 MKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ----MLQQKLGELKEQYSTSL 2302
A+++ L + Q+ I Q+ L+ G + + + +LQ+KLG L ++
Sbjct: 795 --AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 852
Query: 2303 AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGS 2362
Q K+++ ++ L +F +D EF WLE ++ + ++ + L L++
Sbjct: 853 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKL 911
Query: 2363 FSEDVISHKGDLRFVTISGQKVL-----------DMENSFKE------------GKEPSE 2399
E++ +G L+ + +G VL +EN K+ ++ E
Sbjct: 912 LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 971
Query: 2400 IGNLVKD------KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
I +KD KL+D E+ L + + + L + + + +QA
Sbjct: 972 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1031
Query: 2454 EANVEKLLSDTVASDPGVLQEQLAT--TKQLQEELAEHQVPVEKLQK--------VARDI 2503
+ +VE++LS + +E+ AT K+ E+L+ V +L + +A +
Sbjct: 1032 QPDVEEILS----KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1087
Query: 2504 MEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSI 2563
I P + V T +++ + + S E S L + + L +
Sbjct: 1088 TTIGASPT---QTVTLVTQPVVT--KETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1142
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM----ETAD 2619
++Q ++ ++V I E + QD+ +++ LE E++T +T++
Sbjct: 1143 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE---ELITAAQNLKNKTSN 1199
Query: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679
++ ++ + +++++ Q + L ++L + + + +Q + L
Sbjct: 1200 QEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKL 1259
Query: 2680 ASGNQPDQDITHFFQQIQE---LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRV 2736
S + + ++I E L ++ Q N+D L +L A D +
Sbjct: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319
Query: 2737 QNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKE 2796
+N+ + + K V ERE L +F + F WL E E + + + +
Sbjct: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
Query: 2797 LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVG 2856
L + + +K L+ W L EI NL + IL S+ S
Sbjct: 1380 LLEDSKGVKELMKQWQD---LQGEIEAHTDVYHNL---------DENSQKILRSLEGS-- 1425
Query: 2857 SVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWL 2916
D +Q + ++N K+ +L + L+A ++ + +H +L WL
Sbjct: 1426 --------DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 1477
Query: 2917 ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA---------LA 2967
+ K++ L + V+ Q + ++AF EL+ P I E L
Sbjct: 1478 QLKDDELSRQAPIGG--DFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLE 1535
Query: 2968 GLLVTY------PNSQEAEN----WKKIQEELNSRWERATEVTVARQRQLEESASHLACF 3017
GL Y P + A+N +K EE+N+ WE+ + QR+++E+ L
Sbjct: 1536 GLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQEL 1595
Query: 3018 QAAESQLRPWLMEKELMMG---VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
Q A +L L + E++ G +G L ID L ++V+ + E ++ +N+
Sbjct: 1596 QEATDELDLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVND 1653
Query: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQA 3121
A+ + T + LS + L+ +N +W L + R Q+ +A
Sbjct: 1654 LARQLTT--LGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEA 1697
Score = 119 bits (297), Expect = 1e-25
Identities = 248/1464 (16%), Positives = 575/1464 (39%), Gaps = 237/1464 (16%)
Query: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ 2102
L+ QK T Q ++ + W+ QA+ L + + QQ L++ +++L D++ +
Sbjct: 329 LLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD 388
Query: 2103 NRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEA 2162
+ A ++ + ++ KL +++ L + A + + + KELE+
Sbjct: 389 STRDQAANLMAN----RGDHCRKLVEPQISELNHRF--AAISHRIKTGKASIPLKELEQ- 441
Query: 2163 VTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222
S +Q+ E +A + N K+ D D + +LL G +L++
Sbjct: 442 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQR--------GDNLQQR 493
Query: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282
D + + +E+ +QQ L Q HN +
Sbjct: 494 ITD----------------------ERKREEIKIKQQ------------LLQTKHNALKD 519
Query: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 2342
+ ++K E+ Q+ Q++ LK + ++ +L + E + ++ ++EL+
Sbjct: 520 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQ- 576
Query: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP--SEI 2400
E L ++ ++ SED + + + +S ++ ++E+ F + + ++I
Sbjct: 577 -----KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS-KRWREIESKFAQFRRLNFAQI 630
Query: 2401 GNLVKDKLKDATE----RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEAN 2456
+ ++ + TE + + S +H++ L + Q N+ D C +
Sbjct: 631 HTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD-------LCAKD 683
Query: 2457 VEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRH 2516
E L +Q + K +++ L + ++ + ++ ++ +
Sbjct: 684 FEDLF------------KQEESLKNIKDSLQQSSGRIDIIH--SKKTAALQSATPVERVK 729
Query: 2517 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQV- 2575
+QE + ++ ++ +R +++ + + ++ Q + E EQ L Q+
Sbjct: 730 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP 789
Query: 2576 ---SSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAE 2632
+ L + +Q + R +L AT E + ++ + T A++LQ KL
Sbjct: 790 ENWEHAKYKWYLKELQDGIGQRQTVVR---TLNATGEEI---IQQSSKTDASILQEKLGS 843
Query: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2692
++ R++++C Q +++ L++ F+ + ++E + + +P ++
Sbjct: 844 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE---- 899
Query: 2693 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC-----QHQDRVQNLRKD----- 2742
QQ++E +++ E L + ++ +L+ G + + + QD+++N K
Sbjct: 900 -QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 958
Query: 2743 ------FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI-----PPTETS 2791
E Q ++ + KD +++L++ + + WL + P E
Sbjct: 959 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 1018
Query: 2792 MSAKELEKQIEHLKSLLDDWASKG--------------TLVEEINCKGTSLENLIMEITA 2837
+E E ++ + +++ SKG +E+++ + ++ L+ E+ A
Sbjct: 1019 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 1078
Query: 2838 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2897
G L ++G+S + +T + + KL E SL
Sbjct: 1079 KQPDLAPG--LTTIGAS--------PTQTVTLVTQPVVTKETAISKL-----EMPSSLML 1123
Query: 2898 ILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSP 2957
+ + + ++ + WL ++V+KS M E + KA + +LEQ P
Sbjct: 1124 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVG--DLEDINEMIIKQKATMQDLEQRRP 1181
Query: 2958 KIQKVKEALAGL-----------LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ 3006
+++++ A L ++T + W ++QE L +R ++ E+ +
Sbjct: 1182 QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQW 1241
Query: 3007 LEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARR 3066
LE A ++L W KE GP ++D + + + + + K+ +
Sbjct: 1242 LEAKEEAEQVLGQARAKLESW---KE------GPYTVD--AIQKKITETKQLAKDLRQWQ 1290
Query: 3067 QQHEQLNEAAQGILTGPGDVSL-STSQVQKELQSINQKWVELTDKLNSRSSQIDQA---- 3121
+ N+ A +L D S T +V ++IN W + +++ R + +++
Sbjct: 1291 TNVDVANDLALKLLR---DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLL 1347
Query: 3122 -------------IVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSE 3168
+ ++ +LQD + K R + V+ + Q + ++ ++E ++
Sbjct: 1348 QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKE-LMKQWQDLQGEIEAHTD 1406
Query: 3169 IRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRL 3228
+ +L++ ++ + D+ + L++RL+ + L + + + L
Sbjct: 1407 VYHNLDENSQKILRSLEGSDDAVL----------LQRRLDNMNFKWSELRKKSLNIRSHL 1456
Query: 3229 QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHS- 3287
+A+ ++ EL WL K + ++ PI +Q Q + F++ L
Sbjct: 1457 EASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEP 1516
Query: 3288 ---GSYEVI-------VAEGESLLLSVP---PGEEK-----RTLQNQLVELKNHWEELSK 3329
+ E + EG L P P EE+ R L+ Q E+ WE+L+
Sbjct: 1517 VIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNL 1576
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE-LRVTLDPV------QLESSL 3382
+AD Q ++ + +++ Q+ Q ++L D K + +E ++ + PV L+ L
Sbjct: 1577 HSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKGSWQPVGDLLIDSLQDHL 1631
Query: 3383 LRSKAMLNEVEKRRSLLEILNSAA 3406
+ KA+ E+ + + +N A
Sbjct: 1632 EKVKALRGEIAPLKENVSHVNDLA 1655
Score = 67.8 bits (164), Expect = 3e-10
Identities = 156/927 (16%), Positives = 349/927 (37%), Gaps = 160/927 (17%)
Query: 4753 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHV 4812
+K RQ LE ++ + + + +L + LT ++ L A D + E K
Sbjct: 12 KKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--- 68
Query: 4813 LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ 4872
+++D+ +H+ ++E + K + + A + S+++ + + V K
Sbjct: 69 IQSDLTSHEISLEEMKK------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR------- 115
Query: 4873 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEET 4932
Q+ F +++ + L ++ L A + E + QL+ + LY L +
Sbjct: 116 -LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSE 174
Query: 4933 YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4992
++ GR ++ + + + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + +
Sbjct: 175 VEMVIKTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 233
Query: 4993 NSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQ 5052
+ WL + L S + + + S++ K E+ + + + + G
Sbjct: 234 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 293
Query: 5053 LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRS----------------------------I 5084
LK + K++ L+++ L + S W V R+ I
Sbjct: 294 LKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 352
Query: 5085 ERGRSLDDA-RKRAKQFHEAWKKLIDWLEDAESHLDSELE-----ISNDPD--------- 5129
+ LD++ +K+ +Q + K+L L D +DS + ++N D
Sbjct: 353 QADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
Query: 5130 ------------------KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPED 5171
K + L + ++F + + I+ G LKE+ +
Sbjct: 413 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 472
Query: 5172 SQKLDNFLGEVRDKWDTVCGKSVERQHKLEEAL--------------LFSGQFMDALQAL 5217
++ + + E+ + D + + + + + E + L S + AL+
Sbjct: 473 NEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEIS 532
Query: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRE 5271
W Y+ + Q + D++ + + D K+ +EL K+ + ++R
Sbjct: 533 HQW-YQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEG 591
Query: 5272 LIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSE 5331
L E+ V+ +LS RW + + ++ RL A Q R+ M++
Sbjct: 592 LSEDGA--AMAVEPTQIQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMP 646
Query: 5332 AEQTLRFRGALPDDTEALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEV 5379
E + L + T Q+L++ + E + K EE ++ ++
Sbjct: 647 LEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSG 706
Query: 5380 ILAVCHPDCITTIKHWITIIRARFEEVLT-----WAK------QHQQRLETALSELVANA 5428
+ + H ++ + R + +E L+ W K Q R + ++ +
Sbjct: 707 RIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 766
Query: 5429 ELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTY 5488
++ W+ AE L + IP+N + K ++ +++E+ V +T
Sbjct: 767 YDIKIFNQWLTEAEQFLRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTL 818
Query: 5489 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5548
+ G + + Q + IL + ++ L+ RWQ+V
Sbjct: 819 N----------------ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLS 856
Query: 5549 ERQRKLNDALDRLEELKEFANFDFDVW 5575
+R+++L + + L E + N +F +W
Sbjct: 857 DRKKRLEEQKNILSEFQRDLN-EFVLW 882
Score = 44.7 bits (104), Expect = 0.003
Identities = 114/578 (19%), Positives = 219/578 (37%), Gaps = 111/578 (19%)
Query: 1808 EKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQ 1867
E +S L + ++ + + EL D L +L++ +K +V +LE +N+
Sbjct: 1109 ETAISKLEMPSSLMLEVPALADFNRAWTELTDWL---SLLDQVIKSQRVMVG-DLEDINE 1164
Query: 1868 IIISQPQ-----EVPAQLLKALEKDAKNLQKSLSS--VSDTWNSRLLHFQNAVEIEKTKV 1920
+II Q E L+ L A+NL+ S+ R+ QN + + +
Sbjct: 1165 MIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHL 1224
Query: 1921 LNQHTQLEGRLQDLRAWVGNKN---LILNSKGSNSE------IDVDSLNLCLQQYEDLKQ 1971
N+ QL L+D W+ K +L + E VD++ + + + L +
Sbjct: 1225 QNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK 1284
Query: 1972 PMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDAL 2031
+ + + +D +A D+ + +D S R++ + + S++ I
Sbjct: 1285 DLRQWQTNVD-VANDLALKL---LRDYSADDTRKVHMITENINASWRSI----------- 1329
Query: 2032 QGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQ 2091
H + E+EA ++ + LE +W+ +AE Q T ++ L K
Sbjct: 1330 --HKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGV 1387
Query: 2092 SDL----KDLQDDIQ-------NRATSFATVVKDIEGFMEENQTKLSPREL-------TA 2133
+L +DLQ +I+ N + +++ +EG + L R L +
Sbjct: 1388 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG---SDDAVLLQRRLDNMNFKWSE 1444
Query: 2134 LREKLHQAKEQYEALQEETRVAQKELEEAVT-------------------SALQQETEKS 2174
LR+K + EA ++ + L+E + A+Q++ +
Sbjct: 1445 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504
Query: 2175 KAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLP--GMEQLSGASLEKGALDTTDGYMG 2232
+A K + K+ + + S + LT P G+E+L Y
Sbjct: 1505 RAFKRELKTKEPV------IMSTLETVRIFLTEQPLEGLEKL---------------YQE 1543
Query: 2233 VNQAP--EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 2290
+ P E+ +++ + +E+ ++ + L + Q +D+ T E Q LQ+
Sbjct: 1544 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE-----TLERLQELQEA 1598
Query: 2291 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 2328
EL L Q+E Q + D L LQDH E
Sbjct: 1599 TDEL----DLKLRQAEVIKGSWQPVGDLLIDSLQDHLE 1632
>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
Length = 2344
Score = 249 bits (635), Expect = 8e-65
Identities = 337/1747 (19%), Positives = 735/1747 (42%), Gaps = 180/1747 (10%)
Query: 3675 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3734
R+ K L + +A+E E ++ + I++QLA + ++VD QM +
Sbjct: 19 RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA---AYIADKVDAAQMPQEAQK---- 71
Query: 3735 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA--------QLQEALLHC----- 3781
IQS D+ E +EE+ + K+ AQR+ +LQ+ +
Sbjct: 72 --IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQK 122
Query: 3782 -GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQ 3840
F+ L+ L + + + + S E +VV++Q+ L + L + K+ V+M+
Sbjct: 123 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 182
Query: 3841 AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPI 3900
G +I Q + + +++ ++ +L+ + EL +K R++QLE L L+++ + +
Sbjct: 183 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 242
Query: 3901 SDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3960
+++L+ T+ +L V + + ++ KA +++IE + ++G++L ++
Sbjct: 243 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 302
Query: 3961 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKL 4020
E ++ +K+ L + + + R LL + + F ++ + W+ + + L
Sbjct: 303 KKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 361
Query: 4021 SSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQE 4078
K K+DVL R L E+ + + VD L+ L++
Sbjct: 362 DESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEP 414
Query: 4079 KLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYEELTGWLRE---VEEELATSG 4133
++ + R+A I+ + + KA L++ Q + Q E L +++ ++EE
Sbjct: 415 QISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKD 474
Query: 4134 GQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVNEVSRALLELVPWRAREGLDK 4187
+ + QR L++ + + R + + AL +L R ++ L+
Sbjct: 475 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALE- 533
Query: 4188 LVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQAADAELAWVAETKRKLMALG 4242
+S QYK +D + + +D+I+ + R ++ + D EL ++K L
Sbjct: 534 -ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDREL------QKKKEELN 586
Query: 4243 PIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTE 4299
+R + + + A + V+ I + + ++ F+ F Q ++E+T
Sbjct: 587 AVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ----FRRLNFAQIHTVREETM 641
Query: 4300 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQ 4359
++ + + + + + + +S + E L+ A D E
Sbjct: 642 MVMTEDMPLEI------------SYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 689
Query: 4360 LRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418
L +Q+E ++ +++S+ + ID + K L+ P E ++E + + + ++ +
Sbjct: 690 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 749
Query: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPA--EVDKIRECIS 4476
+ R D +V + + FH I+ + L LR IP E K + +
Sbjct: 750 MYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFLRKTQ-IPENWEHAKYKWYLK 805
Query: 4477 DNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4536
+ + + + Q L GEE+I +S D + +Q+KL + W+++ +
Sbjct: 806 ELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQL 858
Query: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4596
+R+ + + + +F D+ + +++ +I PG + + K+++E + + E
Sbjct: 859 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVE 917
Query: 4597 ETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4654
E L+ + G ++ + E+ ++ + + N W +++ E+ ++E
Sbjct: 918 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 977
Query: 4655 AMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE----MKEFKVEVYQQ 4710
++ Q + L+ + + L++ ++ L P+ L E ++E ++ V +
Sbjct: 978 QIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1034
Query: 4711 QIEMEKLNHQGELMLKK--ATDETDRDI---------IREPLTELKHLWENLG------- 4752
Q ++E++ +G+ + K+ AT R + + L EL+ +L
Sbjct: 1035 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 1094
Query: 4753 ----------------EKIAHRQHKLEGALL----ALGQFQHALEELMSWLTHTEELLDA 4792
++ A + ++ +L+ AL F A EL WL+ ++++ +
Sbjct: 1095 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 1154
Query: 4793 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASS-LRSRLE 4851
QR + GD + I + K D+ + +E + A L ++ +A + + R+E
Sbjct: 1155 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 1214
Query: 4852 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPET 4911
+ W+ V + + R QQL L+ + + E+ L + ++L + K +
Sbjct: 1215 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 1274
Query: 4912 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVS 4971
++++ +L L+ + +T + + L LL + K + W +
Sbjct: 1275 IQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333
Query: 4972 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI---ASPPSLILNT---VLSQ 5025
++ ER++ LEE L +F L++F+ WLT AE + N+ A+ +L V
Sbjct: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
Query: 5026 IEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 5084
+++ + E+ AH D LD+ + L+ L D VL++ L ++ +W ++ ++S+
Sbjct: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
Query: 5085 ERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKT 5144
L+ + + K+ H + ++L+ WL+ + L + I D ++ Q H+ F++
Sbjct: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1513
Query: 5145 LGGKQPVYDTTIRTGRAL--------------KEKTLLPED-SQKLDNFL----GEVRDK 5185
L K+PV +T+ T R + + L PE+ +Q + L EV +
Sbjct: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573
Query: 5186 WDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL--DLVMN 5243
W+ + S + Q K++E L + +A L L + E QPV GDL D + +
Sbjct: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQD 1632
Query: 5244 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 5303
++ K + E+ V + R+L + + L++L+TRW L V+
Sbjct: 1633 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKL---LQVA 1689
Query: 5304 KQSRLEQ 5310
+ R+ Q
Sbjct: 1690 VEDRVRQ 1696
Score = 218 bits (554), Expect = 2e-55
Identities = 319/1669 (19%), Positives = 677/1669 (40%), Gaps = 176/1669 (10%)
Query: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046
R+ LL+Q++ +A+ E + ++ DK + ++ D Q A + +
Sbjct: 19 RRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI--QSD 75
Query: 4047 IVNRKKNVDQAIKNGQAL-LKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 4105
+ + + ++++ K+ Q Q ++ + Q+KL + ++ +
Sbjct: 76 LTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF---------------RLF 120
Query: 4106 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 4165
Q F+ +E L EV+ L +S E + L K + E + ++
Sbjct: 121 QKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEM 180
Query: 4166 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 4225
V + R +++ + LD+ V+ Y + + +R +++ ++ S++ + +
Sbjct: 181 VIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMN 240
Query: 4226 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285
W+A T +L + +++ KA +I + K + + +E+
Sbjct: 241 VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI----TEV--- 293
Query: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW---IEE 4342
GE KTVL +K E+L++ + +SLLNS A RA+ +N E + + + ++
Sbjct: 294 -GEALKTVLGKK-ETLVE--DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 349
Query: 4343 TRALIAQLPSPAIDHEQLRQQQEE--MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGE 4400
I Q + + E+ + QQ+E +++L+ + + +P +D Q L G+
Sbjct: 350 ITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD---QAANLMANRGD 406
Query: 4401 ----MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE-NLS 4455
+VE + + + +A I ++ +A ++ +F+ I+ +LE LE +
Sbjct: 407 HCRKLVEPQISELNHRFAAISHRIKT-----GKASIPLKELEQFNSDIQKLLEPLEAEIQ 461
Query: 4456 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA 4515
+ + E D ++ DN+ EL +RG+ L Q +
Sbjct: 462 QGVNLK-----EEDFNKDMNEDNEGTVKEL----------LQRGDNL---QQRITDERKR 503
Query: 4516 KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLE 4575
+EI+ K + +K +R K L++ ++ LL + D + + L
Sbjct: 504 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 563
Query: 4576 SPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMN 4635
P D IK+ + KEE + + + E + GA + + + + + I+
Sbjct: 564 EPR-DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF 622
Query: 4636 NAWENLN-----KTWKERLEKLEDAMQAAVQYQDTL---------QAMFDWLDNTVIKLC 4681
+ LN +E + + + M + Y + QA+ + V +L
Sbjct: 623 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLE-----VEQLL 677
Query: 4682 TMPPV-GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREP 4740
P + D + Q +K K + Q ++ ++ + L+ AT +R ++E
Sbjct: 678 NAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATP-VERVKLQEA 736
Query: 4741 LTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELL-DAQRPISGD 4799
L++L WE + + RQ + + ++ +F + ++ WLT E+ L Q P + +
Sbjct: 737 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 796
Query: 4800 PKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWES 4859
+ L + L++ + Q V T+N G E+++ S+ DAS L+ +L ++N W+
Sbjct: 797 HAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 853
Query: 4860 VLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4919
V ++ +R+++L+ F ++ +F+L L ++ +++ G + +E+L+
Sbjct: 854 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQV 912
Query: 4920 MELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS-KTEQSVALLEQKWHVVSSKMEERK 4978
L +L ++ QL + G +L+S S K E + +W VS + E++
Sbjct: 913 KLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ 972
Query: 4979 SKLEEALNLATEFQNSLQEF-------INWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 5031
++E + + + L++ + WL+ L I + P+ ++E ++
Sbjct: 973 GEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI 1029
Query: 5032 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQ---------- 5081
V A + + E+ G L +K +K L + S W+ V +
Sbjct: 1030 ---AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQP 1084
Query: 5082 -------------------------------RSIERGRSLDDARKRAKQFHEAWKKLIDW 5110
+E SL F+ AW +L DW
Sbjct: 1085 DLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDW 1144
Query: 5111 LEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPE 5170
L + + S+ + D + I + K K + L ++P + I + LK KT E
Sbjct: 1145 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1204
Query: 5171 DSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE 5230
+ + + ++++WD V R+ +L E L S Q+++A + L + +L
Sbjct: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 1264
Query: 5231 DQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQLQE 5289
+ +D + + K K+L + V V +L+ + S DDT V +
Sbjct: 1265 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 1324
Query: 5290 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 5349
++ W ++ K +++ LE+ + + F + L WL+EAE T L D T
Sbjct: 1325 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDATRKE 1381
Query: 5350 QSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPDCITTIKHWITII 5399
+ L D+ KE MK+ ++ + ++ + + +++ ++ D ++ + +
Sbjct: 1382 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 1441
Query: 5400 RARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDR 5459
++ E+ + + LE + + L+ELL W+Q + L + Q PI +
Sbjct: 1442 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 1499
Query: 5460 VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP--TP 5517
V+ H+ F E+ K+P + +E E+ G K +P P
Sbjct: 1500 VQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEGLEKLYQEPRELP 1551
Query: 5518 PPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566
P + + + +++ W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 1552 PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 1600
Score = 211 bits (538), Expect = 1e-53
Identities = 284/1603 (17%), Positives = 653/1603 (40%), Gaps = 161/1603 (10%)
Query: 3872 LLSKAAARQKQLEDILVLAKQFHETA------EPISDFLSVTEKKLANSEPVGTQTAKIQ 3925
+LS+ QK+L+D+ + + F + A + L + L E + +Q
Sbjct: 99 VLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQ 158
Query: 3926 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3985
Q+ L + + ++V +K G+ + L E++ +L+ Y+E+ +
Sbjct: 159 SQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV 218
Query: 3986 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 4045
+ L++ L +R ++ + WLA + +L+ + L + A A +
Sbjct: 219 TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK 278
Query: 4046 EIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQAR 4105
EI +K ++ + G+AL K G++ L+++KL + + + +T + + L L + +
Sbjct: 279 EIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 337
Query: 4106 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 4165
+ F + +T W+ + + L S + P Q + K LK E+ + R +D+
Sbjct: 338 KHMETFDQNVDHITKWIIQADTLLDESEKKKPQ-----QKEDVLKRLKAELNDIRPKVDS 392
Query: 4166 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 4225
+ + L+ R+ ++ +S+ N ++ +S I + + ++ +Q+ +
Sbjct: 393 TRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI--KTGKASIPLKELEQF----N 446
Query: 4226 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285
+++ + E + G E+D + + ++++ D++ + +
Sbjct: 447 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD------- 499
Query: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
E ++ ++ K + L ++ A+ L S+R + Q+ ++L +++
Sbjct: 500 --ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 557
Query: 4346 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 4405
+A LP P D ++++ E+++ +E + + + L + G + + P + ++ ++
Sbjct: 558 KLASLPEPR-DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA-VEPTQIQL-SKR 614
Query: 4406 YQKAENMYAQ-----------IKEE---VRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
+++ E+ +AQ ++EE V + L+ + ST +TE + +LE
Sbjct: 615 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 674
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
+ L++ P L + + + + K+ L++ + + + + + ++
Sbjct: 675 QLLNA----PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 730
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
++Q+ L Q+ F WE + ++R+ +F +E +F YD+ + + + +
Sbjct: 731 ----VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL 786
Query: 4572 HDLESPGIDPSIIKQQVEAAET---IKEETDGLHEELEFIRIL---GADLIFACGETEKP 4625
+ P + E A+ +KE DG+ + +R L G ++I +T+
Sbjct: 787 RKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDAS 838
Query: 4626 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685
+++ + +N W+ + K +R ++LE+ ++Q L WL+ + ++P
Sbjct: 839 ILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPL 897
Query: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT-DETDRDIIREPLTEL 4744
+K++L ++K E+ +Q +++LN G +L A ++D + L +
Sbjct: 898 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 957
Query: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEEL-------MSWLTHTEELLDA--QRP 4795
W + + +Q ++E + LGQ + LE+L + WL+ L+ Q
Sbjct: 958 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 1017
Query: 4796 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855
G V E E+A V A Q VE + G L + ++ +LE ++
Sbjct: 1018 QEGPFDVQETEIA--------VQAKQPDVEEILSKGQHLYKEKPA--TQPVKRKLEDLSS 1067
Query: 4856 CWESV---LQKTEEREQQLQSTLQQAQGFHSEI----------EDFLLELTRMESQLSAS 4902
W++V LQ+ ++ L L ++ ++ + M S L
Sbjct: 1068 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1127
Query: 4903 KPTGGLPETAREQLDTHMELYSQLKAKE-------ETYNQLLDKGRLML----------- 4944
P A +L + L Q+ + E N+++ K + +
Sbjct: 1128 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1187
Query: 4945 --------LSRDDSGSGSKT--EQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4994
L S ++T + ++ +W V ++ R+ +L E L +T++ +
Sbjct: 1188 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1247
Query: 4995 LQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLK 5054
+E L A L ++ + +I E K A ++ + + + +L
Sbjct: 1248 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1307
Query: 5055 FLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDA 5114
D + + ++ + W + +R ER +L++ + +QF +K + WL +A
Sbjct: 1308 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1367
Query: 5115 ESHLD------SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLL 5168
E+ + + + D +K + + ++ Q + VY + +
Sbjct: 1368 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG 1427
Query: 5169 PEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL 5228
+D+ L L + KW + KS+ + LE + + +LQ L+ WL + +L
Sbjct: 1428 SDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 1487
Query: 5229 AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV-------------------QVLKRSG 5269
+ P+ GD V D H+ F++EL + + + L +
Sbjct: 1488 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 1547
Query: 5270 RELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
REL E +++ T ++ Q +E++T W+ + S Q ++++ L++ + ++ L
Sbjct: 1548 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDL 1607
Query: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDV 5370
L +AE + D LID+ ++ ++KV+ R ++
Sbjct: 1608 KLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVKALRGEI 1644
Score = 209 bits (531), Expect = 9e-53
Identities = 336/1819 (18%), Positives = 737/1819 (40%), Gaps = 202/1819 (11%)
Query: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3504
LE+ Q +E ++S I++ + QL + + + + + ++ + Q L + E
Sbjct: 24 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEI 81
Query: 3505 QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564
++ ++ QG A ++L Q +VAQ++ +V + + F
Sbjct: 82 SLEEMKKHNQGK-------EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANF 126
Query: 3565 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3624
R++E L ++ L + + + +QSQ+ + +K ++E R
Sbjct: 127 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 186
Query: 3625 HMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3684
+++++ T + L + AL +L + R++QLE L +++ L +
Sbjct: 187 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 246
Query: 3685 TAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC 3744
A + + V ++ ++A K QKE ++ ++ L+ + +G+ L GK
Sbjct: 247 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKE 305
Query: 3745 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-- 3802
+ +E + +N+ W + + + + L E H F ++ + W+ + L+
Sbjct: 306 TL--VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE 363
Query: 3803 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQL 3862
+ +K P + V+K L+ L+D + VD + + + + R+ + Q+
Sbjct: 364 SEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 416
Query: 3863 ESLESRWTEL-----LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917
L R+ + KA+ K+LE F S +K L EP+
Sbjct: 417 SELNHRFAAISHRIKTGKASIPLKELEQ-----------------FNSDIQKLL---EPL 456
Query: 3918 GTQTAKIQQQI-IRHKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSL 3974
A+IQQ + ++ + +D+ E++ V + ++ G +L +T ++ + K L
Sbjct: 457 ---EAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLL 513
Query: 3975 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKD 4027
Q +++ ++D ++ + + ++L L ++E KL+S+ +K+
Sbjct: 514 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 573
Query: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI---- 4083
+++ ++ EE+ ++ + ++G A+ + T ++ +++
Sbjct: 574 IDRELQKKK--------EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQF 625
Query: 4084 -KTRYADITVTSSKALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSP 4137
+ +A I + + + + L + STY ++ L EVE+ L +
Sbjct: 626 RRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAK 685
Query: 4138 TGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 4197
E + + ++ K +K + + +D ++ A L+ R L + +S + Q++
Sbjct: 686 DFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWE 745
Query: 4198 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ- 4256
V+ R D ++++ +++ W+ E ++ L ++ ++ A+ +
Sbjct: 746 KVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKW 802
Query: 4257 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 4316
K I + + + L + EI + ++LQEK SL +++ + S+R
Sbjct: 803 YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 862
Query: 4317 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 4376
RLE + ++++F E W+EE IA +P +QL+++ E+++ L E +
Sbjct: 863 KRLEEQKNILSEFQRDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPL 921
Query: 4377 HKPHIDKLLKIGPQL---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQ 4433
+ + +L + G + ++PEE + +E K ++ + ++ + ++ E +Q
Sbjct: 922 RQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQ 978
Query: 4434 STQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFE 4493
+ + K+E + E L +L L + P+ +++ N+ ++++ + + +
Sbjct: 979 IKDLGQLEKKLEDLEEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQ 1032
Query: 4494 ALKRRGEELIGRSQGADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEK 4552
A + EE++ + Q K+ A + ++ KL+ + W+ + +E K
Sbjct: 1033 AKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---------- 1082
Query: 4553 FWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG 4612
D+A LTTI SP +++ Q V ET
Sbjct: 1083 -QPDLAPGLTTIG---------ASPTQTVTLVTQPVVTKETA------------------ 1114
Query: 4613 ADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4672
K E+ S+ A + N+ W E + DW
Sbjct: 1115 ---------ISKLEMPSSLMLEVPALADFNRAWTE---------------------LTDW 1144
Query: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4732
L + + + DL + + + + K ++ Q++ ++E+L + + K +++
Sbjct: 1145 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQE 1204
Query: 4733 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4792
R II + + +++ W+ + E + +R+ +L L Q+ A EE L L++
Sbjct: 1205 ARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLES 1264
Query: 4793 QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEA 4852
+ I+ ++ + L D+ Q V+ N +LL + DD + E
Sbjct: 1265 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 1324
Query: 4853 MNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGL 4908
+N W S+ ++ ERE L+ T + Q F ++E FL LT E+ + A++ L
Sbjct: 1325 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 1384
Query: 4909 PET--AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4966
++ +E + +L +++A + Y+ L + + +L S + S ++ + + K
Sbjct: 1385 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 1444
Query: 4967 WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQI 5026
W + K +S LE + + SLQE + WL L + L+ +P V Q
Sbjct: 1445 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1504
Query: 5027 EEHKVFANEVNAHRDQII-------------------ELDQTGNQLKFLSQKQDVV-LIK 5066
+ H+ F E+ I+ +L Q +L + Q+V L++
Sbjct: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1564
Query: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
V + WEK+ S + R +D+ +R ++ EA +L L AE S +
Sbjct: 1565 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG- 1623
Query: 5127 DPDKIKLQLSKHKEFQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRD 5184
D + L H E K L G+ P+ + ++ T L + + L ++
Sbjct: 1624 --DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNT 1681
Query: 5185 KWDTVCGKSVERQHKLEEA 5203
+W + +R +L EA
Sbjct: 1682 RWKLLQVAVEDRVRQLHEA 1700
Score = 155 bits (393), Expect = 9e-37
Identities = 297/1513 (19%), Positives = 615/1513 (40%), Gaps = 181/1513 (11%)
Query: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
+T + + V+Q QL L + L+E + VE + K R I++ + P + + E
Sbjct: 148 ETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENP--KELDERVT 205
Query: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
++ H+ L + ER L+K + S+ +++ + L + + + L +
Sbjct: 206 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 265
Query: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCL 2642
+ +A +++I +QK L++ E V ++T +++ KL+ ++
Sbjct: 266 LDSEVAWGKATQKEIEKQKVHLKSITE-VGEALKTVLGKKETLVEDKLSLLN-------- 316
Query: 2643 QQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNL- 2701
S+ + +AE + +L + Q+ ME DQ++ H + I + +
Sbjct: 317 ------SNWIAVTSRAEEWLNLLLEYQKHMETF----------DQNVDHITKWIIQADTL 360
Query: 2702 ----EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2757
E + Q+ D L+ L EL+ +D +D+ NL + + + + E
Sbjct: 361 LDESEKKKPQQKEDVLKRLKAELNDIRPKVD--STRDQAANLMANRGDHCRKLVE----- 413
Query: 2758 SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL 2817
Q+ E +K + SIP E +++K +E L++ +
Sbjct: 414 ----PQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA---------EI 460
Query: 2818 VEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDV 2877
+ +N K + E D++G +L + + + EI+ +
Sbjct: 461 QQGVNLKEEDFNKDMNE----DNEGTVKELLQRGDNLQQRITDE---RKREEIKIKQQLL 513
Query: 2878 NLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET 2937
K+ L + +R++ I ++ + ++A+ +L+ L+ E+ L S+ K +
Sbjct: 514 QTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKE 573
Query: 2938 VKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERAT 2997
+ + + K EL + + + E A + V Q ++ W++I+ + +++ R
Sbjct: 574 IDRELQKKK---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKF-AQFRRLN 629
Query: 2998 EVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQF 3057
+ R EE+ + E P E+ L ++ +LNA
Sbjct: 630 FAQIHTVR--EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE-QLLNAP----DL 682
Query: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ-KWVELTDKLNSRSS 3116
K+FE +Q E L + G + + S+ LQS + V+L + L+
Sbjct: 683 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDF 742
Query: 3117 QIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE-----ETSEIRS 3171
Q ++ Q EK R + + + T+ E ++ + E ++ +
Sbjct: 743 QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKW 802
Query: 3172 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-------LKKRLETVALPLQGLEDLAADR 3224
L++L + + QT+ L+ GE+ ++ L+++L ++ L Q + +DR
Sbjct: 803 YLKELQDGIGQRQTVVRTLNA-TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 861
Query: 3225 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPIS-AKLERLQSQLQENEEFQKSL 3283
RL+ +FQ+ +E WL+ ++ + P+ K ++L+ +L++ + + L
Sbjct: 862 KKRLEEQKNILSEFQRDLNEFVLWLE--EADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 919
Query: 3284 NQHSGSYEVIVAEGESLLLSVP-PGEEKRTLQNQLVELKNHWEELSKKTADRQ----SRL 3338
G + + G +L+S P EE+ L+N+L + W ++S+ ++Q +++
Sbjct: 920 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 979
Query: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 3398
KD Q +K +ED + +++ L + L P+ R+
Sbjct: 980 KDLGQLEKK-----------LEDLEEQLNHLLLWLSPI-------------------RNQ 1009
Query: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
LEI N + +++G D + + AV QAK +EE+ L + Q
Sbjct: 1010 LEIYN----------QPNQEGPFD----VQETEIAV----QAKQPDVEEI---LSKGQHL 1048
Query: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
+K + + K +LE D N+ L++LRA+Q L + T LV
Sbjct: 1049 YKE-KPATQPVKRKLE--DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVT 1105
Query: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRV--NSGCVMMENKLEGIGQFHCRVREMFSQLA 3576
+ + + + E+ LEV N + + L + Q R M L
Sbjct: 1106 QPVVTKETA--ISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 1163
Query: 3577 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL 3636
D+++ + A +D + + Q+E++ L + S E R ++ +
Sbjct: 1164 DINEMIIKQKATMQDLEQRRPQLEELITAAQ-----NLKNKTSNQEARTIITD------- 1211
Query: 3637 GLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL--Q 3694
+E + Q ++ E + R++QL L +D + L+ +A +A A
Sbjct: 1212 ----RIERIQNQWDEVQEHLQNRRQQLNEML---KDSTQWLEAKEEAEQVLGQARAKLES 1264
Query: 3695 WVVGT-EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDM 3753
W G V+ I +++ + K K+ + Q + N L L++ D D + +
Sbjct: 1265 WKEGPYTVDAIQKKITETKQLAKD-LRQWQTNVDVANDLALKLLRDYSAD-DTRKVHMIT 1322
Query: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-----ANQKPP 3808
E INA W +++K+V++R A L+E +F LE L+WL + E A +K
Sbjct: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
Query: 3809 SAE-YKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA-DREKITGQLESLE 3866
E K VK +++ + LQ ++ L +I +S E + D + +L+++
Sbjct: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
Query: 3867 SRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 3926
+W+EL K+ + LE K+ H + + + +L + + +L+ P+G +Q+
Sbjct: 1443 FKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQK 1502
Query: 3927 QIIRHKALEEDIE 3939
Q H+A + +++
Sbjct: 1503 QNDVHRAFKRELK 1515
Score = 139 bits (349), Expect = 1e-31
Identities = 282/1654 (17%), Positives = 682/1654 (41%), Gaps = 187/1654 (11%)
Query: 2892 QESLQAILNRMEEVHKEANSVLQWLESK---EEVLKSMDAMSSPT-KTETVKAQAESNKA 2947
Q+ LQ + + K AN + ESK +EV + A+ + + + E V++Q
Sbjct: 107 QKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVN 166
Query: 2948 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEV---TVARQ 3004
L + +++ V + ++ ++ EN K++ E + + E+ R+
Sbjct: 167 LYKSLSEVKSEVEMVIKTGRQIV----QKKQTENPKELDERVTALKLHYNELGAKVTERK 222
Query: 3005 RQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEA 3064
+QLE+ + + L WL ++ + + P+ L+++ + KE E
Sbjct: 223 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 282
Query: 3065 RRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK 3124
++ + + E + + T G + V+ +L +N W+ +T S+ ++ +
Sbjct: 283 QKVHLKSITEVGEALKTVLGK---KETLVEDKLSLLNSNWIAVT-------SRAEEWLNL 332
Query: 3125 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET--SEIRSDLEQLDHEVKE 3182
+YQ+ ++ + V + + + + + E K Q +E ++++L + +V
Sbjct: 333 LLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDS 392
Query: 3183 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 3242
+ L G D +K +E L + RI +A++ ++ +Q
Sbjct: 393 TRDQAANLMANRG-----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFN 446
Query: 3243 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ-HSGSYEVIVAEGESLL 3301
+++ L+ P+ A+++ Q + E+F K +N+ + G+ + ++ G++L
Sbjct: 447 SDIQKLLE----------PLEAEIQ--QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQ 494
Query: 3302 LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
+ ++ ++ + L+ L + R+ + + + +Y+ +DL+ ++D
Sbjct: 495 QRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDD 554
Query: 3362 CKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 3418
+ K++ L D +++ L + K LN V ++ L +A + + +
Sbjct: 555 IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKR 614
Query: 3419 G--IRDEKAGINQNMDAVTEELQAKTGSL--EEMTQRLREFQESFKNIEKKVEGAKHQLE 3474
I + A + A ++ +T + E+M + ++ V A LE
Sbjct: 615 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL--LE 672
Query: 3475 IFDALGSQACSNKNLEKLRAQQEVLQALEP-------QVDYLRNFTQGLVEDAPDGSDAS 3527
+ L + K+ E L Q+E L+ ++ ++D + + ++ A +
Sbjct: 673 VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA---TPVE 729
Query: 3528 QLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3585
++ Q ++Q +F +V + + +E +FH ++ +F+Q ++
Sbjct: 730 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIK-IFNQWLTEAEQFLRK 788
Query: 3586 GAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELE 3643
I + + + + +++++ + + + + A+ E ++++ D L+ +L
Sbjct: 789 TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEE---IIQQSSKTDASILQEKLG 845
Query: 3644 ALNKQ----CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVV-- 3697
+LN + C +L++R K +EQ + + +F R L N+ EEA+ + +
Sbjct: 846 SLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQRDL---NEFVLWLEEADNIASIPLE 898
Query: 3698 -GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVNGLGQGLIQSAGKDCDVQG-LEHDME 3754
G E ++ ++L K+ +E PL+ L+Q+N G ++ SA + Q LE+ ++
Sbjct: 899 PGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK 955
Query: 3755 EINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL-------LSWLADTEELIANQKP 3807
+ N +W +++ + ++ +++ + G+ + LE L L WL+ +
Sbjct: 956 QTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQ 1015
Query: 3808 PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 3867
P+ E +QE ++ + ++ V+ + ++G + + E + + +LE L S
Sbjct: 1016 PNQEGPF---DVQETEIA---VQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSS 1067
Query: 3868 RW---TELLSKAAARQKQLEDIL-----------------VLAKQ--------------- 3892
W LL + A+Q L L V+ K+
Sbjct: 1068 EWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLE 1127
Query: 3893 ------FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVH 3946
F+ ++D+LS+ ++ + + + I + II+ KA +D+E +
Sbjct: 1128 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1187
Query: 3947 QAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED 4005
+ + Q+L + TS E + +++++I+ +Q ++ E+Q+ + L++ L ++ + E
Sbjct: 1188 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEA 1247
Query: 4006 EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL 4065
+ E L + KL S + D + ++ + L +++ + NVD A LL
Sbjct: 1248 KEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLL 1307
Query: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
+ + ++ + + I + I S+ LE+ +L +F E+ WL E
Sbjct: 1308 RDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEA 1367
Query: 4126 E------EELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPW 4179
E ++ + + + ++ ++L+ E+ H V ++E S+ +L
Sbjct: 1368 ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL----- 1422
Query: 4180 RAREGLDKLV------SDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAE 4233
R+ EG D V + N ++ + ++A+ + ++ + L W+
Sbjct: 1423 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 1482
Query: 4234 TKRKLMALGPIRLEQDQTTAQLQVQKAF-------------SIDIIR------HKDSMDE 4274
+L PI + Q V +AF +++ +R + +++
Sbjct: 1483 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 1542
Query: 4275 LFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
L+ E+ + T +L+++ E + ++E ++L +++ +++ + + E
Sbjct: 1543 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 1602
Query: 4334 EELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK 4392
+EL + + + P + + L+ E+++ LR IA K ++ + + QL
Sbjct: 1603 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 1662
Query: 4393 ----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
+L+P +E+ + + + +++ VRQ
Sbjct: 1663 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
Score = 120 bits (300), Expect = 5e-26
Identities = 252/1367 (18%), Positives = 508/1367 (37%), Gaps = 188/1367 (13%)
Query: 1843 QAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTW 1902
+A + +EL+ + + + LE + I K + +D + K L D
Sbjct: 434 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 493
Query: 1903 NSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC 1962
R+ + EI+ + L Q L+DLR+ K L ++ + + D L C
Sbjct: 494 QQRITDERKREEIKIKQQLLQTKH--NALKDLRSQRRKKALEISHQWYQYKRQADDLLKC 551
Query: 1963 LQQYE----DLKQPMAERKA------------QLDALAFDIQFFISEHAQDLSPQQNRQM 2006
L E L +P ERK +L+A+ + + A Q+
Sbjct: 552 LDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 611
Query: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVG 2066
+ E++ F AQ+ ++ + E + + +T ++ + +
Sbjct: 612 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 671
Query: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126
+ E+ L +D L K + LK+++D +Q + + ++
Sbjct: 672 EVEQLLNAPD--LCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQS----A 725
Query: 2127 SPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKK 2186
+P E L+E L Q Q+E + + + Q + +V + +
Sbjct: 726 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD-------------- 771
Query: 2187 IDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEM 2246
I W+T + ++ Q PE +
Sbjct: 772 IKIFNQWLTEA------------------------------EQFLRKTQIPENWEH---- 797
Query: 2247 MKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ----MLQQKLGELKEQYSTSL 2302
A+++ L + Q+ I Q+ L+ G + + + +LQ+KLG L ++
Sbjct: 798 --AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 855
Query: 2303 AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGS 2362
Q K+++ ++ L +F +D EF WLE ++ + ++ + L L++
Sbjct: 856 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKL 914
Query: 2363 FSEDVISHKGDLRFVTISGQKVL-----------DMENSFKE------------GKEPSE 2399
E++ +G L+ + +G VL +EN K+ ++ E
Sbjct: 915 LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 974
Query: 2400 IGNLVKD------KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 2453
I +KD KL+D E+ L + + + L + + + +QA
Sbjct: 975 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 1034
Query: 2454 EANVEKLLSDTVASDPGVLQEQLAT--TKQLQEELAEHQVPVEKLQK--------VARDI 2503
+ +VE++LS + +E+ AT K+ E+L+ V +L + +A +
Sbjct: 1035 QPDVEEILS----KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 1090
Query: 2504 MEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSI 2563
I P + V T +++ + + S E S L + + L +
Sbjct: 1091 TTIGASPT---QTVTLVTQPVVT--KETAISKLEMPSSLMLEVPALADFNRAWTELTDWL 1145
Query: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM----ETAD 2619
++Q ++ ++V I E + QD+ +++ LE E++T +T++
Sbjct: 1146 SLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE---ELITAAQNLKNKTSN 1202
Query: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679
++ ++ + +++++ Q + L ++L + + + +Q + L
Sbjct: 1203 QEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKL 1262
Query: 2680 ASGNQPDQDITHFFQQIQE---LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRV 2736
S + + ++I E L ++ Q N+D L +L A D +
Sbjct: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322
Query: 2737 QNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKE 2796
+N+ + + K V ERE L +F + F WL E E + + + +
Sbjct: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
Query: 2797 LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVG 2856
L + + +K L+ W L EI NL + IL S+ S
Sbjct: 1383 LLEDSKGVKELMKQWQD---LQGEIEAHTDVYHNL---------DENSQKILRSLEGS-- 1428
Query: 2857 SVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWL 2916
D +Q + ++N K+ +L + L+A ++ + +H +L WL
Sbjct: 1429 --------DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 1480
Query: 2917 ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA---------LA 2967
+ K++ L + V+ Q + ++AF EL+ P I E L
Sbjct: 1481 QLKDDELSRQAPIGG--DFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLE 1538
Query: 2968 GLLVTY------PNSQEAEN----WKKIQEELNSRWERATEVTVARQRQLEESASHLACF 3017
GL Y P + A+N +K EE+N+ WE+ + QR+++E+ L
Sbjct: 1539 GLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQEL 1598
Query: 3018 QAAESQLRPWLMEKELMMG---VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
Q A +L L + E++ G +G L ID L ++V+ + E ++ +N+
Sbjct: 1599 QEATDELDLKLRQAEVIKGSWQPVGDLLID--SLQDHLEKVKALRGEIAPLKENVSHVND 1656
Query: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQA 3121
A+ + T + LS + L+ +N +W L + R Q+ +A
Sbjct: 1657 LARQLTT--LGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEA 1700
Score = 119 bits (297), Expect = 1e-25
Identities = 248/1464 (16%), Positives = 575/1464 (39%), Gaps = 237/1464 (16%)
Query: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ 2102
L+ QK T Q ++ + W+ QA+ L + + QQ L++ +++L D++ +
Sbjct: 332 LLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD 391
Query: 2103 NRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEA 2162
+ A ++ + ++ KL +++ L + A + + + KELE+
Sbjct: 392 STRDQAANLMAN----RGDHCRKLVEPQISELNHRF--AAISHRIKTGKASIPLKELEQ- 444
Query: 2163 VTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222
S +Q+ E +A + N K+ D D + +LL G +L++
Sbjct: 445 FNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQR--------GDNLQQR 496
Query: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282
D + + +E+ +QQ L Q HN +
Sbjct: 497 ITD----------------------ERKREEIKIKQQ------------LLQTKHNALKD 522
Query: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 2342
+ ++K E+ Q+ Q++ LK + ++ +L + E + ++ ++EL+
Sbjct: 523 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERK--IKEIDRELQ- 579
Query: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP--SEI 2400
E L ++ ++ SED + + + +S ++ ++E+ F + + ++I
Sbjct: 580 -----KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLS-KRWREIESKFAQFRRLNFAQI 633
Query: 2401 GNLVKDKLKDATE----RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEAN 2456
+ ++ + TE + + S +H++ L + Q N+ D C +
Sbjct: 634 HTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPD-------LCAKD 686
Query: 2457 VEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRH 2516
E L +Q + K +++ L + ++ + ++ ++ +
Sbjct: 687 FEDLF------------KQEESLKNIKDSLQQSSGRIDIIH--SKKTAALQSATPVERVK 732
Query: 2517 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQV- 2575
+QE + ++ ++ +R +++ + + ++ Q + E EQ L Q+
Sbjct: 733 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP 792
Query: 2576 ---SSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAE 2632
+ L + +Q + R +L AT E + ++ + T A++LQ KL
Sbjct: 793 ENWEHAKYKWYLKELQDGIGQRQTVVR---TLNATGEEI---IQQSSKTDASILQEKLGS 846
Query: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2692
++ R++++C Q +++ L++ F+ + ++E + + +P ++
Sbjct: 847 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE---- 902
Query: 2693 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC-----QHQDRVQNLRKD----- 2742
QQ++E +++ E L + ++ +L+ G + + + QD+++N K
Sbjct: 903 -QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 961
Query: 2743 ------FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI-----PPTETS 2791
E Q ++ + KD +++L++ + + WL + P E
Sbjct: 962 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 1021
Query: 2792 MSAKELEKQIEHLKSLLDDWASKG--------------TLVEEINCKGTSLENLIMEITA 2837
+E E ++ + +++ SKG +E+++ + ++ L+ E+ A
Sbjct: 1022 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA 1081
Query: 2838 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2897
G L ++G+S + +T + + KL E SL
Sbjct: 1082 KQPDLAPG--LTTIGAS--------PTQTVTLVTQPVVTKETAISKL-----EMPSSLML 1126
Query: 2898 ILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSP 2957
+ + + ++ + WL ++V+KS M E + KA + +LEQ P
Sbjct: 1127 EVPALADFNRAWTELTDWLSLLDQVIKSQRVMVG--DLEDINEMIIKQKATMQDLEQRRP 1184
Query: 2958 KIQKVKEALAGL-----------LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ 3006
+++++ A L ++T + W ++QE L +R ++ E+ +
Sbjct: 1185 QLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQW 1244
Query: 3007 LEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARR 3066
LE A ++L W KE GP ++D + + + + + K+ +
Sbjct: 1245 LEAKEEAEQVLGQARAKLESW---KE------GPYTVD--AIQKKITETKQLAKDLRQWQ 1293
Query: 3067 QQHEQLNEAAQGILTGPGDVSL-STSQVQKELQSINQKWVELTDKLNSRSSQIDQA---- 3121
+ N+ A +L D S T +V ++IN W + +++ R + +++
Sbjct: 1294 TNVDVANDLALKLLR---DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLL 1350
Query: 3122 -------------IVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSE 3168
+ ++ +LQD + K R + V+ + Q + ++ ++E ++
Sbjct: 1351 QQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKE-LMKQWQDLQGEIEAHTD 1409
Query: 3169 IRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRL 3228
+ +L++ ++ + D+ + L++RL+ + L + + + L
Sbjct: 1410 VYHNLDENSQKILRSLEGSDDAVL----------LQRRLDNMNFKWSELRKKSLNIRSHL 1459
Query: 3229 QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHS- 3287
+A+ ++ EL WL K + ++ PI +Q Q + F++ L
Sbjct: 1460 EASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEP 1519
Query: 3288 ---GSYEVI-------VAEGESLLLSVP---PGEEK-----RTLQNQLVELKNHWEELSK 3329
+ E + EG L P P EE+ R L+ Q E+ WE+L+
Sbjct: 1520 VIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNL 1579
Query: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE-LRVTLDPV------QLESSL 3382
+AD Q ++ + +++ Q+ Q ++L D K + +E ++ + PV L+ L
Sbjct: 1580 HSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKGSWQPVGDLLIDSLQDHL 1634
Query: 3383 LRSKAMLNEVEKRRSLLEILNSAA 3406
+ KA+ E+ + + +N A
Sbjct: 1635 EKVKALRGEIAPLKENVSHVNDLA 1658
Score = 65.9 bits (159), Expect = 1e-09
Identities = 155/922 (16%), Positives = 347/922 (37%), Gaps = 160/922 (17%)
Query: 4758 RQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV 4817
RQ LE ++ + + + +L + LT ++ L A D + E K +++D+
Sbjct: 20 RQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDL 76
Query: 4818 LAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4877
+H+ ++E + K + + A + S+++ + + V K Q+
Sbjct: 77 TSHEISLEEMKK------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQK 122
Query: 4878 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL 4937
F +++ + L ++ L A + E + QL+ + LY L + ++
Sbjct: 123 PANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 182
Query: 4938 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4997
GR ++ + + + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + +
Sbjct: 183 KTGR-QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNV 241
Query: 4998 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 5057
WL + L S + + + S++ K E+ + + + + G LK +
Sbjct: 242 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 301
Query: 5058 QKQDVVLIKNLLVSVQSRWEKVVQRS----------------------------IERGRS 5089
K++ L+++ L + S W V R+ I+
Sbjct: 302 GKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL 360
Query: 5090 LDDA-RKRAKQFHEAWKKLIDWLEDAESHLDSELE-----ISNDPD-------------- 5129
LD++ +K+ +Q + K+L L D +DS + ++N D
Sbjct: 361 LDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELN 420
Query: 5130 -------------KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLD 5176
K + L + ++F + + I+ G LKE+ + ++ +
Sbjct: 421 HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 480
Query: 5177 NFLGEVRDKWDTVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLY 5222
+ E+ + D + + + + + E + L S + AL+ W Y
Sbjct: 481 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-Y 539
Query: 5223 KVEPQLAEDQPVHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENS 5276
+ + Q + D++ + + D K+ +EL K+ + ++R L E+
Sbjct: 540 QYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDG 599
Query: 5277 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336
V+ +LS RW + + ++ RL A Q R+ M++ E +
Sbjct: 600 A--AMAVEPTQIQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISY 654
Query: 5337 RFRGALPDDTEALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVC 5384
L + T Q+L++ + E + K EE ++ ++ + +
Sbjct: 655 VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 714
Query: 5385 HPDCITTIKHWITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEE 5433
H ++ + R + +E L+ W K Q R + ++ + ++
Sbjct: 715 HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKI 774
Query: 5434 LLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI 5493
W+ AE L + IP+N + K ++ +++E+ V +T
Sbjct: 775 FNQWLTEAEQFLRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN---- 822
Query: 5494 EPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRK 5553
+ G + + Q + IL + ++ L+ RWQ+V +R+++
Sbjct: 823 ------------ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKR 864
Query: 5554 LNDALDRLEELKEFANFDFDVW 5575
L + + L E + N +F +W
Sbjct: 865 LEEQKNILSEFQRDLN-EFVLW 885
Score = 44.7 bits (104), Expect = 0.003
Identities = 114/578 (19%), Positives = 219/578 (37%), Gaps = 111/578 (19%)
Query: 1808 EKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQ 1867
E +S L + ++ + + EL D L +L++ +K +V +LE +N+
Sbjct: 1112 ETAISKLEMPSSLMLEVPALADFNRAWTELTDWL---SLLDQVIKSQRVMVG-DLEDINE 1167
Query: 1868 IIISQPQ-----EVPAQLLKALEKDAKNLQKSLSS--VSDTWNSRLLHFQNAVEIEKTKV 1920
+II Q E L+ L A+NL+ S+ R+ QN + + +
Sbjct: 1168 MIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHL 1227
Query: 1921 LNQHTQLEGRLQDLRAWVGNKN---LILNSKGSNSE------IDVDSLNLCLQQYEDLKQ 1971
N+ QL L+D W+ K +L + E VD++ + + + L +
Sbjct: 1228 QNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK 1287
Query: 1972 PMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDAL 2031
+ + + +D +A D+ + +D S R++ + + S++ I
Sbjct: 1288 DLRQWQTNVD-VANDLALKL---LRDYSADDTRKVHMITENINASWRSI----------- 1332
Query: 2032 QGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQ 2091
H + E+EA ++ + LE +W+ +AE Q T ++ L K
Sbjct: 1333 --HKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGV 1390
Query: 2092 SDL----KDLQDDIQ-------NRATSFATVVKDIEGFMEENQTKLSPREL-------TA 2133
+L +DLQ +I+ N + +++ +EG + L R L +
Sbjct: 1391 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG---SDDAVLLQRRLDNMNFKWSE 1447
Query: 2134 LREKLHQAKEQYEALQEETRVAQKELEEAVT-------------------SALQQETEKS 2174
LR+K + EA ++ + L+E + A+Q++ +
Sbjct: 1448 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507
Query: 2175 KAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLP--GMEQLSGASLEKGALDTTDGYMG 2232
+A K + K+ + + S + LT P G+E+L Y
Sbjct: 1508 RAFKRELKTKEPV------IMSTLETVRIFLTEQPLEGLEKL---------------YQE 1546
Query: 2233 VNQAP--EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 2290
+ P E+ +++ + +E+ ++ + L + Q +D+ T E Q LQ+
Sbjct: 1547 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE-----TLERLQELQEA 1601
Query: 2291 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 2328
EL L Q+E Q + D L LQDH E
Sbjct: 1602 TDEL----DLKLRQAEVIKGSWQPVGDLLIDSLQDHLE 1635
Score = 33.5 bits (75), Expect = 6.5
Identities = 45/225 (20%), Positives = 99/225 (44%), Gaps = 34/225 (15%)
Query: 5301 SVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRF-------RGALPDDTEALQSLI 5353
+V +Q LEQ+++ A+ ++H++ E L+ ++ L +P + + +QS +
Sbjct: 17 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76
Query: 5354 DTHK---EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEE----- 5405
+H+ E MKK + + ++ +V ++K + A FE+
Sbjct: 77 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD---VSMKFRLFQKPANFEQRLQES 133
Query: 5406 --VLTWAKQHQQRLET-ALSELVANAEL---------LEELLAWIQWAETT---LIQRDQ 5450
+L K H LET ++ + V ++L L E+ + ++ T ++Q+ Q
Sbjct: 134 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 193
Query: 5451 EPIPQNID-RVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIE 5494
P+ +D RV AL + ++T ++ +++ K ++ E
Sbjct: 194 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 238
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 229 bits (585), Expect = 5e-59
Identities = 674/3369 (20%), Positives = 1331/3369 (39%), Gaps = 614/3369 (18%)
Query: 2134 LREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDW 2193
+R+K Q +++ EALQEE + A ++++ A K K+ +L +
Sbjct: 68 IRQKDVQLQQKDEALQEERKAADNKIKKLKLHA-----------------KAKLTSLNKY 110
Query: 2194 VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE 2253
+ + + GG +L P E+ L K +T+ M + + KL ++ E++ +
Sbjct: 111 IEEMKAQGGTVLPTEPQSEE----QLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQ 166
Query: 2254 LLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQ 2313
L Q A Q AQ+ + EE M++Q+L E KE++ ++L +A+L Q Q
Sbjct: 167 LTQAQ-----AEQPAQSSTEM-------EEFVMMKQQLQE-KEEFISTL---QAQLSQTQ 210
Query: 2314 TLQDELQKFLQDHKEFESWLERSEKE-LENMHKGGSSPETLPSLLKRQGSFSEDVISHKG 2372
Q Q + FE+ + E E L+ + + E L Q E S G
Sbjct: 211 AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVG 270
Query: 2373 DLRFVTISGQKVLDME---------------------NSFKEGKEPSEIGNLVKDKLKDA 2411
+ V + Q++ E N+ + +E S+I L++ +
Sbjct: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI--LLEKMELEV 328
Query: 2412 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE----ANVEKLLSDTVAS 2467
ER + H+ L ++ LL Q+ Q + L++ A E A +E+ S ++
Sbjct: 329 AERKLSFHN----LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSL 384
Query: 2468 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH 2527
+ Q A + Q E+ + A+ I ++E + + + + L+
Sbjct: 385 QKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ----FLNR 440
Query: 2528 FQSLSYSLAERSSLLQKAIAQSQSV-QESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEA 2586
+ A ++S +Q+V +E++ SL + + E+E K LSS ++E
Sbjct: 441 LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE---KGALLLSSIELEEL 497
Query: 2587 LATNMKLKQDIA---RQKSSLEATRE------------------------MVTRFMETAD 2619
A N KL I Q + EA RE + F +
Sbjct: 498 KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHK 557
Query: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSG------KLQQFME 2673
+ +L+ K A+ F +L LQ + E + ++L Q EM + + G K++ F+E
Sbjct: 558 ELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEM-KQMEGEGIAPIKMKVFLE 616
Query: 2674 ----------NKSRMLASGNQPDQDITHFFQQIQELNL-----EMEDQQENLDTLEHLVT 2718
N+ L + + H + +E++L E++ +++ D V
Sbjct: 617 DTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVP 676
Query: 2719 ELSSCGFALDLCQHQDRVQNLRKDFTEL-----------QKTVKEREKDASSCQEQLDEF 2767
++ C HQD ++ L+ EL +K + E+ K+ S+ + ++EF
Sbjct: 677 DIGQC--------HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEF 728
Query: 2768 RKLV----RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINC 2823
+K F +E + + + EL Q++ L+ L + + L E
Sbjct: 729 KKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYE--- 785
Query: 2824 KGTSLENLIME-ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYE 2882
T+ +NL+ E I + + K+ + V +Q ++ DV L++
Sbjct: 786 SQTAHDNLLTEQIHSLSIEAKSKDVKIEV------------------LQNELDDVQLQFS 827
Query: 2883 KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQA 2942
+ ++ Q LQ N+ EV + A V + + SK E L +QA
Sbjct: 828 EQSTLIRSLQSQLQ---NKESEVLEGAERV-RHISSKVEEL----------------SQA 867
Query: 2943 ESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVA 3002
S K ELE I K+ + L ++ + + +Q+ + + ++ TE++ +
Sbjct: 868 LSQK----ELE-----ITKMDQLLL---------EKKRDVETLQQTIEEKDQQVTEISFS 909
Query: 3003 RQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEF 3062
++ + L E++ +GV + K+Q+ + +
Sbjct: 910 MTEKMVQ------------------LNEEKFSLGV---------EIKTLKEQLNLLSRAE 942
Query: 3063 EARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAI 3122
EA+++Q E+ NE + G+ ++S Q+ KE + ++ L + R ++ A+
Sbjct: 943 EAKKEQVEEDNEVSSGLKQNYDEMS-PAGQISKE--ELQHEFDLLKKENEQRKRKLQAAL 999
Query: 3123 VKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET--SEIRSDLEQLDHEV 3180
+ +ELLQ +S RL + A + L ET E+ D E ++
Sbjct: 1000 INR---KELLQRVS--------RLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE 1048
Query: 3181 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 3240
K + C E+ + YLK +T++ L+ + D L+ LA+ +QFQ
Sbjct: 1049 KCVTSKCQEIEI-----YLK-------QTISEKEVELQHIRKD----LEEKLAAEEQFQA 1092
Query: 3241 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSL---NQHSGSYEVIVAEG 3297
+ ++ L DK +Q ++ LQ+++ EN+ + L N + + +
Sbjct: 1093 LVKQMNQTLQDKTNQ----------IDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1142
Query: 3298 ESLLLSVP----PGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 3353
E++++S P K L+ +++ L+ E+L KK + + K ++KAQ+ + H+
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1202
Query: 3354 DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS 3413
+ ++ K + L+ D E+ + + +++ R S+ L S S
Sbjct: 1203 E---ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ---QES 1256
Query: 3414 EADEDGIRDE--------------KAGINQNMDAVTEELQAKTG--SLEEMTQRLREFQE 3457
+ G+ + ++ + + + +E+ A G S+ ++ +L+E +
Sbjct: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 3458 SFKNIEKKVEGAKHQL-----EIF---DALGSQACSNKNL---------------EKLRA 3494
+E KV +L E+F + + Q ++L +KL +
Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES 1376
Query: 3495 QQ------EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA----QQEFLEVK 3544
Q E L+ L+P++D L+ ED S S L + E A Q E +E +
Sbjct: 1377 SQLQIAGLEHLRELQPKLDELQKLISKKEEDV---SYLSGQLSEKEAALTKIQTEIIEQE 1433
Query: 3545 QRVNSGCVMMENKL----EGIGQFHCRVREMFSQLADLDDELDGMGAIGR---------- 3590
+ + +E + E I Q + EM + ++ +E I R
Sbjct: 1434 DLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK 1493
Query: 3591 ----DTDSLQSQIEDVRLFLNKIHVLKLDIEAS-EAECRHMLEEEGTLDLLGLKRELEAL 3645
+ SLQ ++ R + ++ D+E+ A+ + G L LL +R+ + +
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERD-KLI 1552
Query: 3646 NKQCGKLTERGKARQ--EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW-----VVG 3698
+ L E E L+L L + + KL ++ +++ AE+ +W +
Sbjct: 1553 TEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
Query: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS--AGK---DCDVQGLEHDM 3753
E EI+ Q + + E++ + ++Q G ++S A K + +Q E +M
Sbjct: 1613 KEYEILLQSYENVSN-EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEM 1671
Query: 3754 EEINARWNTLNKKVAQRIAQLQE------ALLHCG--KFQDALEPLLSWLADTEELIANQ 3805
EE+ + K Q+I +L+E A +H ++ +E LLS A +E +
Sbjct: 1672 EEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731
Query: 3806 KPPSAEYKVVKAQIQ----EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3861
K EY+ + + Q E+ L + D K ++ G +++ A L EK Q
Sbjct: 1732 K---MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQ 1782
Query: 3862 -------LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE--KKLA 3912
+S+ E S + + + + + AK + DF S E L
Sbjct: 1783 TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVS--KDFSSHDEINNYLQ 1840
Query: 3913 NSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID 3972
+ + + A ++++ ++K + +EN + + T E +L E++
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS--------TKDGELKMLQEEVT 1892
Query: 3973 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE--VLNWLAEVEDKLSSVFVKDFKQ 4030
+ +IQ+ R L + A +D++E ++N LAE+ + ++ Q
Sbjct: 1893 KMNLLNQQIQEELSRVTKLKETAEEE-----KDDLEERLMNQLAELNGSIG-----NYCQ 1942
Query: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLD--------- 4081
DV Q + L L E+ N KK V + + Q L+K+ T E + +E L+
Sbjct: 1943 DVTDAQIKNEL-LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEP 2001
Query: 4082 GIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVE-EELATSGGQSPTGE 4140
G K+ ++ + + ++Q ++ ++Q L ++ +E + + T E
Sbjct: 2002 GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKE 2061
Query: 4141 QIPQFQQRQKELKKEVMEHRLVL-DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 4199
+ Q + +K+ + E+ +++L DT +E +R L + + KL + + V
Sbjct: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNL---------KLKKELQSNKESV 2112
Query: 4200 SDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 4259
+ Q+ ++++ ++ EQA + L + KL AL ++ ++T ++QV
Sbjct: 2113 KSQMKQKDEDLE------RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQV-- 2164
Query: 4260 AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTV--LQEKTESLIQQYEA----ISLLNS 4313
T ++ K V LQE +S + Q A +S L
Sbjct: 2165 -------------------------TLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 4314 ERYARLERAQVLVNQFWETY----EELSPWIEETRALIAQLPSPAIDHEQLR---QQQEE 4366
+R ++ A+ +F + EE+ + L QL +I E+L+ + E
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
Query: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK---YQKAENMYAQIKEEVRQR 4423
+Q+ ES A+ + + + K+ L+ N E +EE Y ++N A+++ E++
Sbjct: 2260 DKQIWESKAQTEVQLQQ--KVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK-- 2315
Query: 4424 ALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATV 4483
S Q+T+ + +E E NL +R E D I ++K +
Sbjct: 2316 --------SLKDQLTDLSNSLEKCKEQKGNLEGIIRQ-----QEAD-----IQNSKFSYE 2357
Query: 4484 ELE-KLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIK 4542
+LE LQ S E R EE+ + Q L+ KE E ++
Sbjct: 2358 QLETDLQASRELTSRLHEEINMKEQKIISLLSGKE-------------------EAIQVA 2398
Query: 4543 FLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLH 4602
++ + +K ++ LL+ ++ ++ + +D + Q +E +TIK+E
Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKT--NQLMETLKTIKKENIQQK 2456
Query: 4603 EELE-FIRILGA---DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQA 4658
+L+ F++ + + D G+ ++ E R + + L + KL++ ++
Sbjct: 2457 AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK--DQLIQEAAAENNKLKEEIRG 2514
Query: 4659 AVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN---TVKDQLNEMKEFKVEVYQQQIEME 4715
+ D L + LD +I+ DLN T+KD ++ K+ QQ E+E
Sbjct: 2515 LRSHMDDLNSENAKLDAELIQ------YREDLNQVITIKD--SQQKQLLEVQLQQNKELE 2566
Query: 4716 KLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHA 4775
N +L K E + +R L+ ++L ++I L+ ++ L + A
Sbjct: 2567 --NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEI----ESLKVSISQLTRQVTA 2620
Query: 4776 LEELMSWLTHTEELLDAQRPI--------SGDPKVIEVELAKHHVLKNDVLAHQATVETV 4827
L+E + + +L + + S ++ E+E V K A + E
Sbjct: 2621 LQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE---AAKKVGEIE 2677
Query: 4828 NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIED 4887
+K EL DA +R+ E + + + E EQ+L ++ +G ++I+
Sbjct: 2678 DKLKKEL--KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735
Query: 4888 FLLELTRMESQLSASKPTGGLPETAREQLDTHMELY-SQLKAKEETYNQ-LLDKGRLMLL 4945
F R S L S+ + A E+LD Y + LK + Q LL++ R LL
Sbjct: 2736 F----GRSMSSLQNSR------DHANEELDELKRKYDASLKELAQLKEQGLLNRERDALL 2785
Query: 4946 SRDDSGSGSKTEQSVALLEQKWHVVSSKMEE---RKSKLEEALNLATEFQNSLQEFIN-- 5000
S S E S++ LE+ + SK E+ S+LE++ N F ++ N
Sbjct: 2786 SETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2845
Query: 5001 ---WLTL------AEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 5051
W L E A+ PS T ++++ K + + RD++++ +
Sbjct: 2846 DHLWNELEKFRKSEEGKQRSAAQPS----TSPAEVQSLKKAMSSLQNDRDRLLK-ELKNL 2900
Query: 5052 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWL 5111
Q ++L Q++ + L +Q +K I + + + H+ + W
Sbjct: 2901 QQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSW- 2959
Query: 5112 EDAESHLDSE--LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLP 5169
E E + + + IS+ ++ + +E + + QP+ R +A E + P
Sbjct: 2960 EIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR--QASPETSASP 3017
Query: 5170 EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLA 5229
+ SQ L +R + + + +++ ++++ Q ++ L L L
Sbjct: 3018 DGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLR 3077
Query: 5230 EDQPVHGDL 5238
E+Q +GDL
Sbjct: 3078 ENQQHYGDL 3086
Score = 182 bits (462), Expect = 9e-45
Identities = 626/3420 (18%), Positives = 1349/3420 (39%), Gaps = 453/3420 (13%)
Query: 1238 NQTAEMSCNKVEES---ERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRK 1294
+Q ++M N + ERL E + K +R D + +K + +E D +
Sbjct: 35 HQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQ-EERKAADNKI 93
Query: 1295 PRMSSDAKEFISIINPHNLKGKSLGQVSL-THPYSECDFKLKEVARNNMGNDTNEEQEKA 1353
++ AK ++ +N + + K+ G L T P SE + + + + + K
Sbjct: 94 KKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153
Query: 1354 VTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARV-- 1411
K E+IS ++ + +E+ ++ E+ E + +L ++ + A++
Sbjct: 154 QEKEELISTLQAQLTQAQAEQPAQSSTEM-----EEFVMMKQQLQEKEEFISTLQAQLSQ 208
Query: 1412 -KSKREKREVIVEESIRTCKPAFLSEEKLYQ---ETAIRDEHDSHIKSQPREMTSSEKGK 1467
++++ ++V+ E+ R L E++L Q + + E ++ R++ E+
Sbjct: 209 TQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESL 268
Query: 1468 EADTEMGFSITFKIE--ESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSLCLTLKP 1525
++ + ++ E +Q++ Q + + TL ++ + + L + L+
Sbjct: 269 VGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEV 328
Query: 1526 EENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETN 1585
E R+++ E + L E G+AQ S+ S ++ + ++T+
Sbjct: 329 AE---RKLSFHNLQEEMHHL------LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTS 379
Query: 1586 YQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFS 1645
+ S + +E + + + K Q+ + + + + + K +F
Sbjct: 380 HILS-LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFL 438
Query: 1646 DRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSR 1705
+R L + S TQ +T E N+A L+ +E + ++G+
Sbjct: 439 NRLPLQQHETASQTSFPDVYNE--GTQAVTEE--------NIASLQKRVVE-LENEKGAL 487
Query: 1706 VLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRE 1765
+L S E+L ++ E Q ++ ++ VS + +++ E
Sbjct: 488 LLSSIELEEL---KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA---E 541
Query: 1766 SPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTK 1825
G + + + K + E A + + +L L+ + +L EM+
Sbjct: 542 ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQM 601
Query: 1826 Q---IQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEV--PAQL 1880
+ I P+++ + L+D ++ E L + ++ +Q S+ +
Sbjct: 602 EGEGIAPIKMKVF-LEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE 660
Query: 1881 LKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGN 1940
LK+ ++D KSLS+V D Q+ +E K+++L + +
Sbjct: 661 LKSTKQDG---DKSLSAVPDIGQCH----QDELERLKSQILELELNFHKAQE-----IYE 708
Query: 1941 KNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSP 2000
KNL +K ++ +LN Q E+ K+ + AL+
Sbjct: 709 KNLDEKAK------EISNLN---QLIEEFKKNADNNSSAFTALS---------------- 743
Query: 2001 QQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLED 2060
++ Q+L + EL ++ + AQV L+ +L + E++ + L + T H L
Sbjct: 744 EERDQLLSQVKELS-----MVTELRAQVKQLEMNLAEAERQ---RRLDYESQTAHDNL-- 793
Query: 2061 LCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLK-----DLQDDIQNRATSFATVVKDI 2115
T Q +++ D+K + DD+Q + + +T+++ +
Sbjct: 794 -----------------LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
Query: 2116 EGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSK 2175
+ ++ ++ E L A E R ++EE + Q+E E +K
Sbjct: 837 QSQLQNKES-----------EVLEGA--------ERVRHISSKVEELSQALSQKELEITK 877
Query: 2176 AAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQ 2235
+ L E K+ ++ L + Q +T + + T+ + +N+
Sbjct: 878 MDQLLLEKKRDVETLQQTI----EEKDQQVTEI--------------SFSMTEKMVQLNE 919
Query: 2236 APEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK 2295
L + + +K +Q N + + A+ + + E L+Q E+
Sbjct: 920 EKFSLGVEIKTLK--------EQLNLLSRAEEAKKEQVEEDN----EVSSGLKQNYDEMS 967
Query: 2296 E--QYSTSLAQSEAEL--KQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPE 2351
Q S Q E +L K+ + + +LQ L + KE + R E+EL N+ S +
Sbjct: 968 PAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKD--ESKK 1025
Query: 2352 TLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV-LDMENSFKEGKEPSEIGNLVKDKLKD 2410
+P +G ED + + + VT Q++ + ++ + E + E+ ++ KD
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISE--KEVELQHIRKD---- 1079
Query: 2411 ATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLL-SDTVASDP 2469
E A + L +N L N D LQA + +A ++KL+ S+T ASD
Sbjct: 1080 -LEEKLAAEEQFQALVKQMNQTL---QDKTNQIDLLQAEISENQAIIQKLITSNTDASDG 1135
Query: 2470 G--VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH 2527
L ++ +EH P ++ I+ +E E + +QE
Sbjct: 1136 DSVALVKETVVISPPCTGSSEHWKP-----ELEEKILALEKEKEQLQKKLQE-------- 1182
Query: 2528 FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSG----VI 2583
+L R ++L+KA + + ++E L+ +++ + + + + G +
Sbjct: 1183 ------ALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQL 1236
Query: 2584 QEALATNMKLKQDIARQKSSLEATREMVTR-FMETADSTTAAVLQGKLAE--VSQRFEQL 2640
Q + ++ K Q+ S +T + F T T VL+ L S +
Sbjct: 1237 QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
Query: 2641 CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN 2700
LQ + +K L + E E + +L+ S + + +++ +QI +
Sbjct: 1297 ALQGGTSVAQIKAQLKEIEA-EKVELELKV-----SSTTSELTKKSEEVFQLQEQINKQG 1350
Query: 2701 LEMEDQQENLDTLEHLV-TELSSCGFALDLCQHQ----DRVQNLRKDFTELQKTVKEREK 2755
LE+E +L T+ H S L+ Q Q + ++ L+ ELQK + ++E+
Sbjct: 1351 LEIE----SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEE 1406
Query: 2756 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPP--TETSMSAKELEKQIEHLKSLLDDWAS 2813
D S QL E + Q + E E I T+ M AKE +++I+ L+ L +
Sbjct: 1407 DVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQ 1466
Query: 2814 KGTLVEEINCKGTSLENLIME--ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871
K + E + ++ + I+ ++ + S+ + + G++ K L +++
Sbjct: 1467 KPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE--RLTKSLADVE 1524
Query: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2931
+S N + + + G L QE ++ M+ E S+ ES + L+ + +
Sbjct: 1525 SQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL----T 1580
Query: 2932 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN-SQEAENWKKIQEELN 2990
K + VK + +AE + K +++++ LL +Y N S EAE + + E +
Sbjct: 1581 EDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVR 1640
Query: 2991 SRWE------RATEVTVAR-QRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043
+ R+TE ++QL+E+ + + + ++R + K+ + L
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEM---EEMKEKMRKFAKSKQQK---ILELEE 1694
Query: 3044 DPNMLNAQ--------KQQVQFML-------KEFEARRQQHEQLNEAAQGILTGPGDVSL 3088
+ + L A+ K+ ++ +L +E E + ++E L++ Q +++ +S
Sbjct: 1695 ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE 1754
Query: 3089 STSQVQKELQS--INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 3146
++ +++ Q +E T+K +++++ ++ E LS R
Sbjct: 1755 EVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE- 1813
Query: 3147 SVQSAISTQPEAVK------------QQLEETSEIRSDLEQLDHEVKE-AQTLCDELSVL 3193
SV SA S P K QQ+++ E + LE+ + KE +QTL +E + L
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL 1873
Query: 3194 IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDE--------- 3244
+ + KD K L+ + L + ++R+ + ++ + +E
Sbjct: 1874 LSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAEL 1933
Query: 3245 ---LRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL 3301
+ + D Q KN + ++++ L+ + E EE ++ L + E +E
Sbjct: 1934 NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE---SEIRKEY 1990
Query: 3302 LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
L G +K K+H +EL + ++Q +K + +YQ + L ++
Sbjct: 1991 LEKIQGAQKEPGN------KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKA 2044
Query: 3362 CKAKMSELRVTLDPVQ--LESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDG 3419
+ +E + L+ + L ++ K E+ + LL+ S A ++ + +
Sbjct: 2045 LEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKE 2104
Query: 3420 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFDA 3478
++ K + M E+L+ + EE + L+E KN+++K++ + + + + +
Sbjct: 2105 LQSNKESVKSQMKQKDEDLERRLEQAEE--KHLKEK----KNMQEKLDALRREKVHLEET 2158
Query: 3479 LGS-QACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQ--AEV 3535
+G Q NK ++++ QE L + Q+ L +D D ++ + ++
Sbjct: 2159 IGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDA 2218
Query: 3536 AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSL 3595
Q + E++ + ++ C +++++L Q + E+ ++ L+ + + + L
Sbjct: 2219 IQSKEEEIRLKEDN-CSVLKDQLR---QMSIHMEELKINISRLEHDKQIWESKAQTEVQL 2274
Query: 3596 QSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTER 3655
Q ++ D NK + +L+ E RH+ +L L+ EL++L Q L+
Sbjct: 2275 QQKVCDTLQGENKELLSQLE------ETRHLYHSSQN-ELAKLESELKSLKDQLTDLSNS 2327
Query: 3656 GKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQ 3715
+ +EQ G +E R+ + D + E L+ + E+ ++ + M +
Sbjct: 2328 LEKCKEQK----GNLEGIIRQQEA--DIQNSKFSYEQLETDLQASRELTSRLHEEINMKE 2381
Query: 3716 KEQVDPLQMKLQQVNGLGQGLIQSAGKDC-DVQGLEHDMEEINARWNTLNKKVAQRIAQL 3774
++ + L K + + L Q K+ +++ L EE N NKK + QL
Sbjct: 2382 QKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL 2441
Query: 3775 QEALLHCGK--------FQDALEPLLSWLADTEELIANQKPPSAEY--------KVVKAQ 3818
E L K ++ + S D + ++ + + + ++++
Sbjct: 2442 METLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEA 2501
Query: 3819 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELAD-REKITGQLESLESRWTELLSKAA 3877
E L+ + ++ +D L +E ++ AEL RE + + +S+ +LL
Sbjct: 2502 AAENNKLKEEIRGLRSHMDDLNSENAKL--DAELIQYREDLNQVITIKDSQQKQLLEVQL 2559
Query: 3878 ARQKQLEDILV-LAKQFHETAEPISD----FLSVTEKKLANSEPVGTQTAKIQQQIIRHK 3932
+ K+LE+ L ++ E+ E D F ++ E+K S+ + + I Q +
Sbjct: 2560 QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2619
Query: 3933 ALEEDIENHATDVHQAVKIGQS----LSSLTSPAEQGV--LSEKIDSLQA----RYSEIQ 3982
AL+E E H +K+ + LS+L S +++ + L E++ +Q + EI+
Sbjct: 2620 ALQE--EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIE 2677
Query: 3983 DRCCRKAALLDQ---ALSNARLFGEDEV-EVLNWLAEVEDKLSSVF---------VKDFK 4029
D+ ++ L + N E+ V E+ L E+E KL V ++ F
Sbjct: 2678 DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737
Query: 4030 QDVLHRQHA-DHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYA 4088
+ + Q++ DH NEE+ K+ D ++K L +Q L+ + D + + A
Sbjct: 2738 RSMSSLQNSRDHA--NEELDELKRKYDASLKELAQLKEQG------LLNRERDALLSETA 2789
Query: 4089 -DITVTSSKALRTLEQARQ-----------LATKFQSTYEELTGWLREVEEELATSGGQS 4136
+ T +L LE+ Q L+++ + +Y ++ + + + + +
Sbjct: 2790 FSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMA---SLQNERD 2846
Query: 4137 PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQY 4196
++ +F++ ++ ++ + V + +A+ L R+ L K + + +QY
Sbjct: 2847 HLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQ--NDRDRLLKELKNLQQQY 2904
Query: 4197 KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMA----LGPIRLEQDQTT 4252
I Q + E+ + Q+Y+ A E +++ ++ L +R+E+
Sbjct: 2905 L----QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWE 2960
Query: 4253 AQLQVQKAFSIDIIRHKDS-MDELFSHRSEIFGTCGEEQKTVLQ-------------EKT 4298
+ K + I KD + L + E+ + + Q +Q + +
Sbjct: 2961 IHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGS 3020
Query: 4299 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358
++L+ + E + ++ + + ++ + Q + +L +EE L QL + +
Sbjct: 3021 QNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQL---LEEKNTLSIQLCDTS---Q 3074
Query: 4359 QLRQQQEEMRQLRESIAEHKPHIDKL----LKI-----GPQLK-----ELNPEEGEMVEE 4404
LR+ Q+ L A + + +L L I PQ K + +PEE ++
Sbjct: 3075 SLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQ 3134
Query: 4405 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464
+ +A+ ++EV + L+E Q E + LE+ P+I
Sbjct: 3135 SFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPII 3194
Score = 97.8 bits (242), Expect = 3e-19
Identities = 340/1795 (18%), Positives = 720/1795 (40%), Gaps = 278/1795 (15%)
Query: 3761 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
NT + V +R+A ++ ++ + +D + L +E + ++ +A+ K+ K ++
Sbjct: 44 NTTQEDVQERLAYAEQLVV---ELKDIIRQKDVQLQQKDEALQEERK-AADNKIKKLKLH 99
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRI----------------AQSAELADREKITGQLES 3864
+ L L ++ ++A+GG + + + E + EKI +L+
Sbjct: 100 AKAKLTSL----NKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE 155
Query: 3865 LESRWTEL---LSKAAARQK-----QLEDILVLAKQFHETAEPISDF---LSVTEKKLAN 3913
E + L L++A A Q ++E+ +++ +Q E E IS LS T+ + A
Sbjct: 156 KEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
Query: 3914 SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS----- 3968
+ V + A+ + Q+ H E+++ T ++ Q L L E+ S
Sbjct: 216 QQVVREKDARFETQVRLH---EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRA 272
Query: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
+ +D LQ + + R +Q LS E E L E E + S + ++
Sbjct: 273 QVVDLLQQELTAAEQR--------NQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM 324
Query: 4029 KQDVLHRQHADHLALNEEI-----------------------VNRKKNVDQAIKNGQALL 4065
+ +V R+ + H L EE+ + +K + K L
Sbjct: 325 ELEVAERKLSFH-NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383
Query: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSK-ALRTLEQARQLATKFQSTYEELTGWLRE 4124
Q TG+E +Q D +K + + + ++ A+++ + +QL + Q +E++ +L
Sbjct: 384 LQKTGQE---LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440
Query: 4125 V---EEELATS---------GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRA 4172
+ + E A+ G Q+ T E I Q+R EL+ E + L+L ++ E+
Sbjct: 441 LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE--KGALLLSSI-ELEEL 497
Query: 4173 LLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVA 4232
E ++ L + + E + VS+ + +D A +RS E++ L
Sbjct: 498 KAENEKLSSQITLLEAQNRTGEADREVSE-----ISIVDIANKRSSSAEESGQDVLENTF 552
Query: 4233 ETKRKLMALGPIRLEQDQTTA-----QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCG 4287
K K +++ + +++ Q QLQ ++A D + +D+ + E G
Sbjct: 553 SQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEAD----HEVLDQKEMKQMEGEGIAP 608
Query: 4288 EEQKTVLQEKTESL-IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS-----PWIE 4341
+ K L++ + + E SL +E+ Q T EE+S ++
Sbjct: 609 IKMKVFLEDTGQDFPLMPNEESSL------PAVEKEQASTEHQSRTSEEISLNDAGVELK 662
Query: 4342 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE--- 4398
T+ + S D Q Q +E+ +L+ I E + + K +I + + +E
Sbjct: 663 STKQDGDKSLSAVPDIGQCHQ--DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN 720
Query: 4399 -GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSR 4457
+++EE + A+N + +R L + V + + +TE +++ + L +
Sbjct: 721 LNQLIEEFKKNADNNSSAFTALSEERDQLLSQ-VKELSMVTELRAQVKQLEMNLAEAERQ 779
Query: 4458 LRMPPLIPAEVD-----KIRECISDNKSATVELEKLQPSFEALKRRGEE---LIG--RSQ 4507
R+ D +I + KS V++E LQ + ++ + E LI +SQ
Sbjct: 780 RRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ 839
Query: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567
+K+ E +++ + E++ ++E++ + +L + D+ L TI++
Sbjct: 840 LQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEK 899
Query: 4568 QDIVHDLE---------------SPGIDPSIIKQQVE----AAETIKEETDGLHEELEFI 4608
V ++ S G++ +K+Q+ A E KE+ + +E +
Sbjct: 900 DQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL 959
Query: 4609 RILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQA 4668
+ D + G+ K E++ D + E + + L ++ +Q + ++ L
Sbjct: 960 K-QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELAN 1018
Query: 4669 MFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA 4728
+ D + P+ T + ++ E KE K Y ++ K + E+ LK+
Sbjct: 1019 LKDESKKEI-------PLS---ETERGEVEEDKENKE--YSEKCVTSKCQ-EIEIYLKQT 1065
Query: 4729 TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE 4788
E + EL+H+ ++L EK+A + QFQ ++++ L
Sbjct: 1066 ISEKE--------VELQHIRKDLEEKLAAEE-----------QFQALVKQMNQTLQDKTN 1106
Query: 4789 LLDA-QRPISGDPKVIEVELAKHH---------VLKNDVLAHQATVETVNKAGNELLES- 4837
+D Q IS + +I+ + + ++K V+ + EL E
Sbjct: 1107 QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKI 1166
Query: 4838 -SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE----- 4891
+ + L+ +L+ +++L+K +E+E+ L+ L+Q + ++ +++ E
Sbjct: 1167 LALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKEN 1226
Query: 4892 ------LTRMESQLSASKPTGGLPETAREQLDTHMELYSQ--LKAKEETYNQLLDKGRLM 4943
L +++ Q+ S G LP T +++ + + KA E+ + Q + + L
Sbjct: 1227 ENIGDQLRQLQIQVRESID-GKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLC 1285
Query: 4944 --LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS---LQEF 4998
S + S + SVA ++ + + ++ E + K+ + T+ LQE
Sbjct: 1286 PDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ 1345
Query: 4999 INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVN-AHRDQIIELDQTGNQL-KFL 5056
IN L +SL S + + L Q K+ ++++ A + + EL ++L K +
Sbjct: 1346 INKQGLEIESLKTVSHEAEVHAESLQQ----KLESSQLQIAGLEHLRELQPKLDELQKLI 1401
Query: 5057 SQKQ-DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAE 5115
S+K+ DV + L ++ K+ IE+ + K H + ++
Sbjct: 1402 SKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI-------KALHTQLEMQAKEHDERI 1454
Query: 5116 SHLDSEL-EISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-Q 5173
L EL E+ P++I + ++ Q+ L ++ ++L+E+ L + +
Sbjct: 1455 KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
Query: 5174 KLDNFLGEVRDKW-------DTVCGKSVERQHKLEEAL------LFSGQFMD-------- 5212
+L L +V + DTV G+ Q + ++ + L Q +
Sbjct: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574
Query: 5213 ALQALVDWLYKVEPQL-----------AEDQPVHGDLDLVMN-LMDAHKVFQKELGKRTG 5260
AL+ L + K+ ++ E Q H +L L+ +++ E +
Sbjct: 1575 ALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQH 1634
Query: 5261 TVQVLKRSGRELI-------ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 5313
V+ +++ +EL N ++ ++ QE+ + + K + SKQ ++ + +
Sbjct: 1635 VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEE 1694
Query: 5314 QAEVFRDTVHMLLEWLSEAEQTLRFRGA-LPDDTEALQSLIDT-HKEFMKKVEEK 5366
+ + R VH + E +TL A + ++ E ++ +T K+F + EK
Sbjct: 1695 ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEK 1749
Score = 94.4 bits (233), Expect = 3e-18
Identities = 425/2347 (18%), Positives = 904/2347 (38%), Gaps = 363/2347 (15%)
Query: 481 EFQFSSQNKEYPDREDCTTEKGK------KTTVETEDSSVENPEQDLFVEQKERNPNIDA 534
E + +NKEY ++ C T K + K T+ ++ +++ +DL +
Sbjct: 1036 EVEEDKENKEYSEK--CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQAL 1093
Query: 535 LKVINKVKLE-------VQRQLIGTQREDQTAVSVRENASRGHLLTI--------PPA-- 577
+K +N+ + +Q ++ Q Q ++ +AS G + + PP
Sbjct: 1094 VKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTG 1153
Query: 578 EAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTC---------------------QNEQAH 616
+E +++ + ++E K++ Q + T Q + +
Sbjct: 1154 SSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYN 1213
Query: 617 TLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKL------ELKSETDGNVHPLDK---- 666
L+ ++ +I Q ++LQ+QV++++ KL E S T G PL K
Sbjct: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQ 1273
Query: 667 --KEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEAT 724
+ + ++ L D S++A + GG+ + K ++ E LEL +T
Sbjct: 1274 HHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE-----KVELELKVSST 1328
Query: 725 LNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESL 784
+ L+ + + EQ ++ L E++ SH A E L Q +S +
Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLK---TVSHEAEVHAESL---QQKLESSQLQIA 1382
Query: 785 TTEEVIN-EGLMDE--KLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRI 841
E + + +DE KL+ +SG L + L ++ + +++E +
Sbjct: 1383 GLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI----IEQEDLIKA 1438
Query: 842 LERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLIS 901
L Q+ +R K++ V L ++ +PE I E +K + ++ ++ LIS
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELC------EMKQKPEEIGEESRAK-QQIQRKLQAALIS 1491
Query: 902 LQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNA 961
+ L S+ RG +ER LTK + D + +S D
Sbjct: 1492 RKEAL------KENKSLQEELSLARGTIER------LTKSLAD--VESQVSAQNKEKDTV 1537
Query: 962 F-RHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAF 1020
R L+ E E+ K + ++ + N + K + L+ +T D ++ ++E+++
Sbjct: 1538 LGRLALLQE---ERDKLITEMDRSLLENQSLSSSCESLK-LALEGLTEDKEKLVKEIESL 1593
Query: 1021 TGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDI 1080
+ + + E KE E +L + V E RI E V++ K ++
Sbjct: 1594 KSSKI----AESTEWQEKHKELQKEYEILL---QSYENVSNEAERIQHVVEAVRQEKQEL 1646
Query: 1081 ESGQRYLEVIPFSDIK---------DGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTG 1131
R E K + + +K+ +++ Q ++ L A+ +
Sbjct: 1647 YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
Query: 1132 GIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIE--KR 1189
G DTA TL S+ + E + R+ ++ L+ + S ++ +L E ++ K
Sbjct: 1707 G--DTAKECMETLLSS--NASMKEELERVKMEYETLSKKFQSLMS-EKDSLSEEVQDLKH 1761
Query: 1190 LISPELANMIQIDSSEFSDHRAQI--EKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNK 1247
I ++ ++++E D++ + E + I + + L C+++ + +
Sbjct: 1762 QIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 1248 VEESERLF----QVENQSAQ-EKVKVRVSDGEQAK-KSREIS----------LKEFGCKD 1291
+ F ++ N Q +++K R++ E+ K K++E S L + KD
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD 1881
Query: 1292 QRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLKEVARN-------NMGN 1344
+ + + ++++N ++ + L E L+E N ++GN
Sbjct: 1882 GELKMLQEEVTK-MNLLN-QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN 1939
Query: 1345 DTNEEQEKAVTKIEIISHMKQSTSCL-----DSEEIRENQGEVILEVQETYCET---SGK 1396
+ + + + S MK C+ + +++ + + +V E+++ Y E + K
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
Query: 1397 LPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQ 1456
P + + + +K K+++ + + ++ IR + E + ++ E ++
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059
Query: 1457 PREMTSS-EKGKEADTEMGFSITFKI-----EESSSQVVPQGISVKHLDALTLFSSKQAN 1510
+ + E K+A E+ +FK+ + +++V+ + +K S K
Sbjct: 2060 KENLAQAVEHRKKAQAELA---SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 1511 EGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQIS 1570
+ K +L L E++L + + + R E +H +E+ G+ QVT ++
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDAL-----RREKVHLEETIGEIQVT----LN 2167
Query: 1571 KTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNE----CKEKSYQEVSFDPARGLKL 1626
K DK Q Q DS VT TK S ++ E E F A K
Sbjct: 2168 KKDKEVQ----QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKE 2223
Query: 1627 EEITVSRP----------------DSKEVRYLEFSDRKDLHHQGSKSD----DKLCGTLK 1666
EEI + + ++ K + ++++ K+C TL+
Sbjct: 2224 EEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQ 2283
Query: 1667 ---SEIATQELTGEKFLEMANPNVAGLEA--GSIEDIVTQRGSRVLGSFLPEKLFKGVSQ 1721
E+ +Q + +A LE+ S++D +T + + + +G+ +
Sbjct: 2284 GENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR 2343
Query: 1722 KENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGK 1781
++ QN+ S LET + + LT +L E ++ ++ GK
Sbjct: 2344 QQEADIQNSKFSYEQLETDLQASRELT------------SRLHEEINMKEQKIISLLSGK 2391
Query: 1782 GNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLL 1841
V +L +HD K+I+ LE L++ ++
Sbjct: 2392 ----------EEAIQVAIAELRQQHD-----------------KEIKELENLLSQEEE-- 2422
Query: 1842 CQAKVLERELK---DLTTLVSQELECVNQIIISQPQEVPA--QLLKALEKDAKNLQKSLS 1896
+ VLE E K D T + + L+ + + I Q ++ + + + +L+ D +
Sbjct: 2423 -ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481
Query: 1897 SVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDV 1956
+ + S +L ++ + ++ +L+ ++ LR+ + + N N+++D
Sbjct: 2482 QLEERHLSIILEKDQLIQ----EAAAENNKLKEEIRGLRSHMDDLN------SENAKLDA 2531
Query: 1957 DSLNLCLQQYEDLKQPMAERKAQLDAL---------AFDIQFFISEHAQDLSPQQNRQML 2007
+ +Q EDL Q + + +Q L + ++ E S + N +
Sbjct: 2532 E----LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR 2587
Query: 2008 RLLNELQRSFQDI---LEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSW 2064
R N LQ QD+ +E + L + +++E + Q +++ L +
Sbjct: 2588 RSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSAL 2647
Query: 2065 VGQAERALAGHQGRTTQQDLSALQKNQS-DLKDLQDDIQNRATSFATVVKDIEGFMEENQ 2123
+++ +A +++L +QK + + +++D ++ + G M N+
Sbjct: 2648 FSSSQKRIA-----ELEEELVCVQKEAAKKVGEIEDKLKKELKH----LHHDAGIM-RNE 2697
Query: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183
T+ + + L L + +++ + +E + +++ S + + A +EL E
Sbjct: 2698 TETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDEL 2757
Query: 2184 KKKIDALLDWVTSVGSSG--GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 2241
K+K DA L + + G + L S S E+ +L + +NQ D
Sbjct: 2758 KRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLE---KLNQQLLSKD 2814
Query: 2242 KQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKE--QYS 2299
+Q + ++ ++ +Q Q+F A A L +L E ++ + + G+ + Q S
Sbjct: 2815 EQLLHLSSQLEDSYNQVQSF----SKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870
Query: 2300 TSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKR 2359
TS A+ ++ K + +LQ++ + L++ K + + +E+ +H L + L+
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH-------PLKAQLQE 2923
Query: 2360 QGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALH 2419
++ + +LR +S Q L K E E + E+Y
Sbjct: 2924 YQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHE---------RRMKEQYLMAI 2974
Query: 2420 SKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATT 2479
S + SHL L+ + S + Q + ++ S ++ P Q + T
Sbjct: 2975 SDKDQQLSHLQNLIRELR-------SSSSQTQPLKVQYQRQASPETSASPDGSQNLVYET 3027
Query: 2480 KQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERS 2539
+ L+ +L + L+++ + + I+ + S+F L L E++
Sbjct: 3028 ELLRTQLN------DSLKEIHQKELRIQ---------------QLNSNFSQL---LEEKN 3063
Query: 2540 SLLQKAIAQSQSVQESLE---SLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
+L + SQS++E+ + LL +E KQV L +G + +A +++
Sbjct: 3064 TLSIQLCDTSQSLRENQQHYGDLLNHCAVLE-----KQVQELQAGPLNIDVAPGAPQEKN 3118
Query: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
+KS E RE F E + ++ E+ + E+ Q+ E++L
Sbjct: 3119 GVHRKSDPEELREPQQSFSEAQQQLCNT--RQEVNELRKLLEEERDQRVAAENALSVAEE 3176
Query: 2657 QAEMFEH 2663
Q EH
Sbjct: 3177 QIRRLEH 3183
Score = 81.3 bits (199), Expect = 3e-14
Identities = 300/1600 (18%), Positives = 632/1600 (39%), Gaps = 227/1600 (14%)
Query: 4001 LFGEDEVEVLNWLAE-VEDKLSSV--FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 4057
L E ++E N E V+++L+ V + K D++ ++ +E + +K D
Sbjct: 34 LHQESDMEFNNTTQEDVQERLAYAEQLVVELK-DIIRQKDVQLQQKDEALQEERKAADNK 92
Query: 4058 IKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEE 4117
IK LK ++ + + ++ +K + + T ++ L + + +T+ + E+
Sbjct: 93 IKK----LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEK 148
Query: 4118 LTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELV 4177
+ L+E EE ++T Q T Q Q Q E+++ VM + + + +S +L
Sbjct: 149 IKHKLQEKEELISTLQAQL-TQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLS 207
Query: 4178 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRK 4237
+A + ++V + + +++ + DE+ Q AD E E ++K
Sbjct: 208 QTQAEQAAQQVVREKDARFET---QVRLHEDEL-------LQLVTQADVE----TEMQQK 253
Query: 4238 LMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK 4297
L L +LE+ + + V +A +D+++ EL T E++ +L ++
Sbjct: 254 LRVLQR-KLEEHEESL---VGRAQVVDLLQQ-----EL---------TAAEQRNQILSQQ 295
Query: 4298 TESLIQQYEAI-SLLNSERYAR---LERAQVLVNQFWETYEELSPWIEETRALIAQLPSP 4353
+ + ++ + + + +ER LE+ ++ V + ++ L EE L+ Q
Sbjct: 296 LQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQ---EEMHHLLEQFEQA 352
Query: 4354 AIDHEQLRQQQEEMRQLRESIAEHKP-HIDKLLKIGPQLKE----LNPEEGEMVEEKYQK 4408
+L + + Q ++ E K HI L K G +L+ L + +++++K ++
Sbjct: 353 GQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQ 412
Query: 4409 A---ENMYAQIKEEVRQRALALDEAVS-------QSTQITEFHDKIEPMLE--TLENLSS 4456
A Q++++++Q++ + + ++ ++ T F D + T EN++S
Sbjct: 413 AVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIAS 472
Query: 4457 RLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSF---EALKRRGEELIGRSQGADKDL 4513
+ + E + + + E EKL EA R GE S+ + D+
Sbjct: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532
Query: 4514 AAK-----------------------------EIQDKLDQMVFFWEDIKA-RAEEREIKF 4543
A K E+++ +++ F ++ RAEE + +
Sbjct: 533 ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEV 592
Query: 4544 LDVLELAEKFWYDMAALLTTI--KDT-QDIVHDLESPGIDPSIIKQQVEAAETIK-EETD 4599
LD E+ + +A + + +DT QD P++ K+Q + E
Sbjct: 593 LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI 652
Query: 4600 GLHE---ELEFIRILGADLIFA------CGETEKPEVRKSIDEM----NNAWENLNKTWK 4646
L++ EL+ + G + A C + E ++ I E+ + A E K
Sbjct: 653 SLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLD 712
Query: 4647 ERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVE 4706
E+ +++ + Q +++ DN + L + +L+ + E + +
Sbjct: 713 EKAKEISNLNQLIEEFKKNA-------DNNSSAFTALSEERDQLLSQVKELSMVTELRAQ 765
Query: 4707 VYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGAL 4766
V Q ++ + + Q L + T + ++ E + L ++ KI Q++L+
Sbjct: 766 VKQLEMNLAEAERQRRLDYESQTAHDN--LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQ 823
Query: 4767 LALGQFQHALEELMSWLTHTE-ELLDAQ---RPISGDPKVI-------EVELAKHHVL-- 4813
L + + L S L + E E+L+ R IS + + E+E+ K L
Sbjct: 824 LQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLL 883
Query: 4814 --KNDVLAHQATVETVNKAGNELLES-------------SAGDDASSLRSRLEAMNQCWE 4858
K DV Q T+E ++ E+ S S G + +L+ +L +++ E
Sbjct: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEE 943
Query: 4859 SVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT 4918
+ ++ EE + ++ S L+Q S E + E L K + L
Sbjct: 944 AKKEQVEE-DNEVSSGLKQNYDEMSPAGQISKEELQHEFDL-LKKENEQRKRKLQAALIN 1001
Query: 4919 HMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER 4977
EL ++ EE L D+ + + LS + G + +++ E+ V+SK +E
Sbjct: 1002 RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEK---CVTSKCQEI 1058
Query: 4978 KSKLEEALN-LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV 5036
+ L++ ++ E Q+ ++ L EQ + + L +QI+ + +E
Sbjct: 1059 EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISEN 1118
Query: 5037 NAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI-ERGRSLDDARK 5095
A ++I + + ++ ++ V+I W+ ++ I + + +K
Sbjct: 1119 QAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK 1178
Query: 5096 RAKQFHEAWKKLIDWLEDAESHLDSELEISNDP-DKIKLQLSKHKEFQKTLGGKQPVYDT 5154
+ ++ + K ++ ++ E HL EL+ D ++++ Q + + + +G +
Sbjct: 1179 KLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQI 1238
Query: 5155 TIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 5214
+R K LP Q+ +S LEE L + +
Sbjct: 1239 QVRESIDGK----LPSTDQQ-----------------ESCSSTPGLEEPLFKATEQHHTQ 1277
Query: 5215 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGT-VQVLKRSGRELI 5273
L E L D P H + DA + + GT V +K +E+
Sbjct: 1278 PVL-------ESNLCPDWPSHSE--------DASAL-------QGGTSVAQIKAQLKEIE 1315
Query: 5274 ENSRDDTTWVKGQLQELSTRWDTVCKLS--VSKQSRLEQALK----QAEVFRDTVHMLLE 5327
+ V EL+ + + V +L ++KQ ++LK +AEV +++ LE
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPD 5387
L+ G + LQ +D ++ + K EE ++ ++ E L
Sbjct: 1376 -----SSQLQIAGL--EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ-- 1426
Query: 5388 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQ 5447
T I +I+A ++ AK+H +R++ EL + EE+ E+ Q
Sbjct: 1427 --TEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEI-----GEESRAKQ 1479
Query: 5448 RDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKT 5487
+ Q + + K + E+++ EE++ + ++R+TK+
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS 1519
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 220 bits (561), Expect = 3e-56
Identities = 693/3497 (19%), Positives = 1348/3497 (38%), Gaps = 423/3497 (12%)
Query: 1907 LHFQNAVEIEKTKVLNQ-------HTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSL 1959
LH V+ TK+L Q TQ E + DL W+ K + L ++ + ++
Sbjct: 249 LHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLP--AM 306
Query: 1960 NLCLQQYEDL----KQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQR 2015
L + K P +++ +AL F +Q + AQ+ P + L L EL +
Sbjct: 307 RQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQ--AQNRRPFLPHEGLGLA-ELSQ 363
Query: 2016 SFQDILEQTAAQVDALQGHLQQMEQ-EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAG 2074
+ + AA+ ALQ L Q+++ E L + Q + L+D AE+ L
Sbjct: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKD-------AEQVL-- 414
Query: 2075 HQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTAL 2134
Q R L+ ++ L L+ I + F + + + +E + +
Sbjct: 415 DQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWAD-----V 469
Query: 2135 REKLHQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKELAENKKKIDALLD 2192
+ + +++ L + + +K++ + AV S LQ+ S +EL E +
Sbjct: 470 ARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARS------ 523
Query: 2193 WVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQ 2252
T+ G +++ L + L GA + + L E+++A+ +
Sbjct: 524 --TACGQQLAEVVELLQRHDLLEAQVSAHGA-HVSHLAQQTAELDSSLGTSVEVLQAKAR 580
Query: 2253 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 2312
L QQ+ + ++ +A L+Q T + + L+ E +E + Q
Sbjct: 581 TLAQLQQSLVALVRARRALLEQ-----TLQRAEFLRNC--EEEEAWLKECGQRVGNAALG 633
Query: 2313 QTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSS-----PETLPSLLKR----QGSF 2363
+ L ++ LQ HK E+ + R + ++ + G P T P +R QG +
Sbjct: 634 RDLS-QIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGW 692
Query: 2364 S---EDVISHKGDLRFVTISGQKVLDMENS---FKEGKEPSEIGNLVKDKLKDATERYTA 2417
V+ L+ + Q D + +E + E + +D+ A E
Sbjct: 693 QLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQA--AAETLLR 750
Query: 2418 LHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLA 2477
H + R+ F L+ +A A ++ S PG E L
Sbjct: 751 RHVRLERV----------LRAFAAELRRLEEQGRAASARASLFTVNSALSPPG---ESLR 797
Query: 2478 TTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSL 2535
E H P + + M + EP PD + +T D + ++SL
Sbjct: 798 NPGPWSEASC-HPGPGDAWK------MALPAEPDPDFDPNTILQTQDHLSQDYESLRALA 850
Query: 2536 AERSSLLQKAIA------QSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALAT 2589
R + L++A+A +Q LE + V+ + +V L ALA
Sbjct: 851 QLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAV 910
Query: 2590 NMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKES 2649
L +++ SS E R+ +ST +Q + E+SQR+ QL ++EK
Sbjct: 911 GKGLWAEVS---SSAEQLRQRYP-----GNSTQ---IQRQQEELSQRWGQLEALKREKAV 959
Query: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709
L + + Q + ++ A +D H Q Q+ L +E
Sbjct: 960 QLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLE---RR 1016
Query: 2710 LDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK 2769
+ L+ +V ++ G+A + Q +V+ L+ ++Q+ V +R + + Q + F +
Sbjct: 1017 VHFLQSVVVKVEEPGYA-ESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQAR-QSFLQ 1074
Query: 2770 LVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLE 2829
+ W + + + E S+ ++ + + LL++ +++++ + +
Sbjct: 1075 ESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA 1134
Query: 2830 NLIMEITAPDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGV 2887
L PDSQ T +L G + K L E + L+ +K G
Sbjct: 1135 AL----DCPDSQEVPNTLRVLGQQGQEL---------KVLWEQRQQWLQEGLELQKFGRE 1181
Query: 2888 LHERQESL---QAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAES 2944
+ + QA L+ ++ + ++ L L+ E + + + + E ++A E
Sbjct: 1182 VDGFTATCANHQAWLH-LDNLGEDVREALSLLQQHREFGRLLSTLGP--RAEALRAHGEK 1238
Query: 2945 NKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQ 3004
++ P V+E L + + ++W R + R+
Sbjct: 1239 L------VQSQHPAAHTVREQL--------------------QSIQAQWTRLQGRSEQRR 1272
Query: 3005 RQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEA 3064
RQL S L ++ ++L W+ EK LM P N+L K+ + E A
Sbjct: 1273 RQLLASLQ-LQEWKQDVAELMQWMEEKGLM-AAHEPSGARRNILQTLKRH-EAAESELLA 1329
Query: 3065 RRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVK 3124
R+ E L + + +L+ +Q LQ + KW L K+ R ++ QA
Sbjct: 1330 TRRHVEALQQVGRELLSRR---PCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQA--- 1383
Query: 3125 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQ 3184
Q ++LL+ L + + Q ++ A+ Q Q L + ++ +QL+ E++
Sbjct: 1384 -GQQEQLLRQLQDAKEQLEQ---LEGAL--QSSETGQDLRSSQRLQKRHQQLE---SESR 1434
Query: 3185 TLCDELSVLIGEQY-------LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 3237
TL +++ L + + +E +K L + L L+ A R +LQA++ Q
Sbjct: 1435 TLAAKMAALASMAHGMAASPAILEETQKHLRRLEL----LQGHLAIRGLQLQASV-ELHQ 1489
Query: 3238 FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG 3297
F + + +W+ + + L QS ++++E Q + H G + +++ G
Sbjct: 1490 FCHLSNMELSWVAEHMPHGSPTSYTEC-LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSG 1548
Query: 3298 ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKA---QKYQWHVED 3354
SL S P + + + Q EL+ HW EL + R C+Q+A Q+Y V +
Sbjct: 1549 RSLAASGHP--QAQHIVEQCQELEGHWAELERACEARAQ----CLQQAVTFQQYFLDVSE 1602
Query: 3355 LVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE 3414
L W+E+ + +S D + + +A+ E+ S +E L+ A L
Sbjct: 1603 LEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEV 1662
Query: 3415 ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLE 3474
++ + E+ + + + A+ +EL A E T RL EF ++++ + K +
Sbjct: 1663 PEQQRVVQER--LREQLRAL-QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAK 1719
Query: 3475 IFDALGSQACSNKNL-EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD-GSDASQLLHQ 3532
++LG +L K Q ++ +V R + L+E G Q
Sbjct: 1720 GGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD 1779
Query: 3533 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3592
+ A E E+ Q E L + H + E+ +Q+ + L + RD
Sbjct: 1780 LQTAWSELWELTQARGHALRDTETTL----RVHRDLLEVLTQVQEKATSLPNN--VARDL 1833
Query: 3593 DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3652
L++Q L L+ ++ +E + + +LE G + L + A+ ++ +
Sbjct: 1834 CGLEAQ-------LRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAV 1886
Query: 3653 TERG---KARQEQLELTLGRVEDFYRKLKGLND-ATTAAEEAEALQWVVGTEVEIINQQL 3708
T+ + R EQ L R R + D A+ AA + LQ ++
Sbjct: 1887 TQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLK 1946
Query: 3709 ADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC-----DVQGLEHDMEEINARWNTL 3763
+ + +++ + QQ LGQ + +AG +++ L+ +++ W
Sbjct: 1947 LSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARK 2006
Query: 3764 NKKVAQRIAQLQEALLHCGKFQDAL---------EPLLSWLADTEELIANQ----KPPSA 3810
+++ Q Q Q L CG+ ++ L L S + + E+LI K +A
Sbjct: 2007 QERL-QAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTA 2065
Query: 3811 EYKVVKAQIQEQKLLQR---------LLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3861
+ K A + K L+R LL R ++ ++ G + S +A + Q
Sbjct: 2066 QDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQ 2125
Query: 3862 LESLESRWTELLSKAAARQKQLEDILVLAKQ--FHETAEPISDFLSVTEKK----LANSE 3915
E W + L + + + L K F + + ++ KK LA S
Sbjct: 2126 AEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSH 2185
Query: 3916 PVGTQTAKIQQQIIRH----------KALEEDIENHATDVHQAVKIGQS-LSSLTSPAEQ 3964
P + ++ Q + +H + E + + + Q V + ++ +
Sbjct: 2186 PRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNV 2245
Query: 3965 GVLSEKID---SLQARYSEIQ---------DRCCRKAALLDQALSNARLFGEDEVEVLNW 4012
G L + ++ L+ R E + D C R + L L N +EV+++
Sbjct: 2246 GDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR---DPEEVKII-- 2300
Query: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRK-KNVDQAIKNGQALLKQTT-G 4070
+ +L++ + F ++L Q AL +++R+ NV + I+ +AL++ G
Sbjct: 2301 -CQRRSQLNNRWAS-FHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCG 2358
Query: 4071 EEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA 4130
+++ +Q L + ++ ++ + +LE R++ Q + E G LR ++E+A
Sbjct: 2359 KDLESVQRLLRKHEELEREVHPIQAQ-VESLE--REVGRLCQRSPEAAHG-LRHRQQEVA 2414
Query: 4131 TSGGQ-----SPTGEQIPQFQQRQK------ELKKEVMEHRLVLDT-------------V 4166
S Q E + Q QK EL R +DT +
Sbjct: 2415 ESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRML 2474
Query: 4167 NEVSRALLELVPWR-----AREGLDKLVSDAN---EQYKLVSDTIGQRVDEIDAAIQRSQ 4218
E EL W AR +L++ + + V + Q + ++ A Q Q
Sbjct: 2475 EEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQ 2534
Query: 4219 -QYEQAADAEL---------AWVAETKRKLMALG---------PIRLEQDQTTAQLQVQK 4259
Q +QA + +L W+ + L + G P+ + L+VQ
Sbjct: 2535 LQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQA 2594
Query: 4260 AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARL 4319
K S E + R G E Q + + ++++ + EA+ R RL
Sbjct: 2595 G--------KISALEATA-RGLHQGGHPEAQSAL--GRCQAMLLRKEALFRQAGTRRHRL 2643
Query: 4320 ERAQVLVNQFWETYEELSPWIEETR--ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH 4377
E + L F + +E++ W+ E AL L A+ QL++QQ +L S+ +
Sbjct: 2644 EELRQL-QAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ 2702
Query: 4378 KPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQI 4437
+ +L + G +L + E ++E+ ++ ++ ++++ +++ L +A ++ ++
Sbjct: 2703 Q----ELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC-EALRL 2757
Query: 4438 TEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKR 4497
+++E LE +E LR P + A + + E + + +L+ + + R
Sbjct: 2758 RRSMEELENWLEPIE---VELRAPTVGQA-LPGVGELLGTQR-------ELEAAVDKKAR 2806
Query: 4498 RGEELIGRSQGADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWY 4555
+ E L+G++Q ++ A++++++ +++ ++ ++ +ER L+ L KF+
Sbjct: 2807 QAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA-LEARSLLLKFFR 2865
Query: 4556 DMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADL 4615
D + +++ + + G S ++ E + ++ E HE L + +
Sbjct: 2866 DADEEMAWVQEKLPLAA-AQDYGQSLSAVRHLQEQHQNLESEMSS-HEALTRVVLGTGYK 2923
Query: 4616 IFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDN 4675
+ G EV + ++ A +L R L+ A Q A Q+ L WL
Sbjct: 2924 LVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQA-QEAQQFLTELLEAGSWLAE 2982
Query: 4676 TVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRD 4735
L + +G + L ++ K ++ +E+L L+ + E+ +
Sbjct: 2983 RGHVLDS-EDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKV 3041
Query: 4736 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4795
+ + L ++ L + R H L+ L L Q + L +WLT ++Q
Sbjct: 3042 LAQ--LQAVREAHAELLRRAEARGHGLQEQL-QLHQLERETLLLDAWLTTKAATAESQ-D 3097
Query: 4796 ISGDPKVIEVELAKHHVLKNDVLA-HQATVETVNKAGNELLESSAG--DDASSLRSRLEA 4852
D + ++V K + +V + QA V + K L + + RSR+EA
Sbjct: 3098 YGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEA 3157
Query: 4853 MNQCWESVLQKTEEREQQLQST--LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPE 4910
WE + Q + R + L + + Q +E++ + E T L + G
Sbjct: 3158 ---AWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTA----LMKGEDGGHSLS 3210
Query: 4911 TAREQLDTHMELYSQLKAKEETYNQLLDKG-RLMLLSRDDSGSGSKTEQSVALLEQKWHV 4969
+ R H L +L+A E+ +L + RL L G +K +++ W
Sbjct: 3211 SVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEA-------WAT 3263
Query: 4970 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ--IE 5027
+ +K +ER L +A F QE + W A++ +AS L + ++ +
Sbjct: 3264 LQAKAQERGQWLAQAAQ-GHAFLGRCQELLAW---AQERQELASSEELAEDVAGAEQLLG 3319
Query: 5028 EHKVFANEVNAHRDQIIELDQTGNQL----KFLSQKQDVVL--IKNLLVSVQSRWEKVVQ 5081
+H+ E+ R Q +L Q G QL F+S + L ++ L ++ W Q
Sbjct: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQ 3379
Query: 5082 RSIERG--RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK 5139
R E + L ++A+ + W+ L+ + S D EL + D KL ++ +
Sbjct: 3380 RCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEE 3439
Query: 5140 EF---QKTLGGK----QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGK 5192
+F QKT + QP R G +L P Q L L E RD D
Sbjct: 3440 KFAQMQKTEMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQGLGAQLAETRDPQDAKGTP 3499
Query: 5193 SVERQHKLEEALLFSGQ 5209
++E + ++ LL G+
Sbjct: 3500 TMEGSLEFKQHLLPGGR 3516
Score = 219 bits (557), Expect = 8e-56
Identities = 481/2424 (19%), Positives = 964/2424 (39%), Gaps = 264/2424 (10%)
Query: 3215 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 3274
+ L LA R RL+ A+A F EL+ WL+ + + P + LE +Q +
Sbjct: 844 ESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKY- 901
Query: 3275 ENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR 3334
E F +L G + + + E L P + +Q Q EL W +L ++
Sbjct: 902 --ENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQ--IQRQQEELSQRWGQLEALKREK 957
Query: 3335 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA----MLN 3390
+L H ++ ++++C +LR L +QLE+ S L
Sbjct: 958 AVQLA-----------HSVEVCSFLQECGPTQVQLRDVL--LQLEALQPGSSEDTCHALQ 1004
Query: 3391 EVEKRRSLLE----ILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL------QA 3440
+K+ +LE L S + A+ ++ + + + V E++ QA
Sbjct: 1005 LAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQA 1064
Query: 3441 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 3500
+T + + Q ++ ++++ ++ + +++ A LE++ QE LQ
Sbjct: 1065 ETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQ 1124
Query: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560
L+ Q + D PD + L V Q+ E+K ++ LE
Sbjct: 1125 QLDAQSQPMAAL------DCPDSQEVPNTLR---VLGQQGQELKVLWEQRQQWLQEGLE- 1174
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
+ +F V + A+ L + +G D S ++ R F + L EA
Sbjct: 1175 LQKFGREVDGFTATCANHQAWLH-LDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALR 1233
Query: 3621 AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGL 3680
A +++ + ++ +L+++ Q +L R + R+ QL L L
Sbjct: 1234 AHGEKLVQSQHPAAHT-VREQLQSIQAQWTRLQGRSEQRRRQL-------------LASL 1279
Query: 3681 NDATTAAEEAEALQWVVGTEVEIINQQ-------LADFKMFQKEQVDPLQMK--LQQVNG 3731
+ AE +QW+ + ++ L K + + + L + ++ +
Sbjct: 1280 QLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQ 1339
Query: 3732 LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPL 3791
+G+ L+ + C + ++ ++ + ++W LN+K+ +R +LQ+A E L
Sbjct: 1340 VGRELLSR--RPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQA--------GQQEQL 1389
Query: 3792 LSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG----G 3844
L L D +E + + S + +++ + QK Q+L + + + A G
Sbjct: 1390 LRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHG 1449
Query: 3845 RIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL 3904
A A L + +K +LE L+ A R QL+ + + H+ + L
Sbjct: 1450 MAASPAILEETQKHLRRLELLQGH-------LAIRGLQLQ----ASVELHQFCHLSNMEL 1498
Query: 3905 SVTEKKLANSEPVG-TQTAKIQQQIIR-HKALEEDIENHATDVHQAVKIGQSLSSLTSPA 3962
S + + + P T+ Q + R HK L+ +++ H V + + G+SL++ P
Sbjct: 1499 SWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQ 1558
Query: 3963 EQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSS 4022
Q ++ E+ L+ ++E++ C +A L QA++ + F D E+ W VE+K
Sbjct: 1559 AQHIV-EQCQELEGHWAELERACEARAQCLQQAVTFQQYF-LDVSELEGW---VEEKRPL 1613
Query: 4023 VFVKDFKQD--VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 4080
V +D+ +D R H AL EE+ ++++ + Q L E+ ++QE+L
Sbjct: 1614 VSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERL 1673
Query: 4081 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE 4140
++ T R LE +L +F E+L GWL ++ A GG+S GE
Sbjct: 1674 REQLRALQELAATRD---RELEGTLRLH-EFLREAEDLQGWL--ASQKQAAKGGES-LGE 1726
Query: 4141 ----------QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS 4190
+ +FQ + + + V RL+ +++ E + +V R ++ L +
Sbjct: 1727 DPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD----LQT 1782
Query: 4191 DANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQ 4250
+E ++L + G + + + ++ + L + + + K +L P + +D
Sbjct: 1783 AWSELWEL-TQARGHALRDTETTLRVHRDL-------LEVLTQVQEKATSL-PNNVARDL 1833
Query: 4251 T--TAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 4308
AQL+ + +++ + + EL + C Q +Q++ +++ Q + +
Sbjct: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVL 1893
Query: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPW---------IEETRALIAQLPSPAIDHEQ 4359
+R A+LERA++L +F + + W +EE+ + P H+
Sbjct: 1894 QRRMEQRRAQLERARLLA-RFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQW 1952
Query: 4360 LRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ-------KAENM 4412
LR + E +L + + LL G KE+ E + +++ Q K E +
Sbjct: 1953 LRAELEAREKLWQQATQLGQQA--LLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERL 2010
Query: 4413 YAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIR 4472
A+ +E++ R E + + +++ + +E +E L + + + DK
Sbjct: 2011 QAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDK-- 2068
Query: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
K A + E+L K L ++D+L ++ +
Sbjct: 2069 ------KEAALR-ERL----------------------KTLRRPRVRDRLPILLQRRMRV 2099
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKD-TQDIVHDLESPGIDPSIIKQQVEAA 4591
K AE R L +A + AA T +D Q L+ P + P ++ +++
Sbjct: 2100 KELAESRGHALHASLLMAS---FTQAA--TQAEDWIQAWAQQLKEP-VPPGDLRDKLKPL 2153
Query: 4592 ---ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER 4648
+ + E HEE+ + + A EV + + + WE+L + R
Sbjct: 2154 LKHQAFEAEVQA-HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALR 2212
Query: 4649 LEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVY 4708
++LED +++ + W+ +K+ + +G DL ++EF+
Sbjct: 2213 GQELEDRRNF-LEFLQRVDLAEAWIQEKEVKM-NVGDLGQDLEHCLQLRRRLREFRGNSA 2270
Query: 4709 QQQIEMEKLNHQGELMLK-KATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL 4767
+ + +L L+ K D + II + ++L + W + + Q +LEGAL
Sbjct: 2271 GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGAL- 2329
Query: 4768 ALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETV 4827
+ L+ + + E L+ A D + ++ L KH L+ +V QA VE++
Sbjct: 2330 EIHVLSRELDNVTKRIQEKEALIQAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESL 2388
Query: 4828 NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIED 4887
+ L + S + A LR R + + + W + + ++R + L + L QAQ + +++
Sbjct: 2389 EREVGRLCQRSP-EAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAMLQE 2446
Query: 4888 FLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR 4947
L+ R+ +Q+ S P P AR L+ H E ++L + ++ + G+ +L +
Sbjct: 2447 LLVSAQRLRAQMDTS-PAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG 2505
Query: 4948 DDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ 5007
S + Q +A LEQ+ + +E + +L++AL L F +S+++ WL E
Sbjct: 2506 HPFSSDIR--QVLAGLEQELSSLEGAWQEHQLQLQQALELQL-FLSSVEKMERWLCSKED 2562
Query: 5008 SLNIASPPSLILNTVLSQIE----EHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVV 5063
SL S L L+ +E +HK+ ++ +I L+ T L +
Sbjct: 2563 SL-----ASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQS 2617
Query: 5064 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 5123
+ + R E + +++ R L++ R+ + F + +++ WL E +L + E
Sbjct: 2618 ALGRCQAMLL-RKEALFRQAGTRRHRLEELRQ-LQAFLQDSQEVAAWLR--EKNLVALEE 2673
Query: 5124 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE-----KTLLPEDSQKLDNF 5178
D + QL K + FQ L R G+ L + + E ++L
Sbjct: 2674 GLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGAL 2733
Query: 5179 LGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD- 5237
GE++D K V + K EAL + +++ L +WL +E +L P G
Sbjct: 2734 WGELQDNSQ----KKVAKLQKACEAL----RLRRSMEELENWLEPIEVELRA--PTVGQA 2783
Query: 5238 LDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 5297
L V L+ + + + K+ + L + + V+ Q + L R+ ++
Sbjct: 2784 LPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSL 2843
Query: 5298 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 5357
+ +++ LE + FRD + W+ E + L A++ L + H+
Sbjct: 2844 REPLQERRTALEARSLLLKFFRDADEEMA-WVQE-KLPLAAAQDYGQSLSAVRHLQEQHQ 2901
Query: 5358 EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRL 5417
++ + G ++ H H + + E+ + + R
Sbjct: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGH-----FAAHEVAARVQQLEKAMAHLRAEAARR 2956
Query: 5418 ETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 5477
L + + L ELL W D E + + + +AL+ + ++
Sbjct: 2957 RLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAF 3016
Query: 5478 QPDVDRVTKT----YKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRI 5533
P ++R+ +T RKN E +P + R++ ++ +L ++EA+ +
Sbjct: 3017 SPRIERLQQTAALLESRKNPE---SPKVLAQLQAVREAHAE-------LLRRAEARGHGL 3066
Query: 5534 NQLSARWQQVWLLALERQRKLNDA 5557
+Q+ L LER+ L DA
Sbjct: 3067 Q------EQLQLHQLERETLLLDA 3084
Score = 209 bits (533), Expect = 5e-53
Identities = 673/3423 (19%), Positives = 1315/3423 (38%), Gaps = 451/3423 (13%)
Query: 2075 HQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRE---- 2130
HQG+T Q+ L+ + + + LQ T + +V D+ ++ E Q +L R+
Sbjct: 250 HQGQTVQRRLTKILLQLQETELLQ-------TQYEQLVADLLRWIAEKQMQLEARDFPDS 302
Query: 2131 LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDAL 2190
L A+R+ L A + ++ R+ Q+ EA+ LQ + L + L
Sbjct: 303 LPAMRQLL-AAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAEL 361
Query: 2191 ------LDWVTSVGSSG-GQLLTNLPGMEQLSGASLEKGALDTT---DGYMGVNQA---P 2237
L+W + S Q L L +E L+ K AL + D ++QA P
Sbjct: 362 SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
Query: 2238 EKL---DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGEL 2294
L + + + +L Q+ F + A + H+ + ++ E+
Sbjct: 422 ASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWAD-----VARRQEEV 476
Query: 2295 KEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLP 2354
++ L + + KQV +Q L LQ+ + LE ++ + G E +
Sbjct: 477 TVRWQRLLQHLQGQRKQVADMQAVLS-LLQEVEAASHQLEELQEPARSTACGQQLAEVV- 534
Query: 2355 SLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATER 2414
LL+R V +H + + Q+ ++++S E +++ K + +
Sbjct: 535 ELLQRHDLLEAQVSAHGAHVSHLA---QQTAELDSSLGTSVE------VLQAKARTLAQL 585
Query: 2415 YTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANV-EKLLSDTVASDPGVLQ 2473
+L + + L L Q +F + + +AW++ C V L ++ G LQ
Sbjct: 586 QQSLVALVRARRALLEQTL-QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQ 644
Query: 2474 EQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS---------- 2523
+ K L+ E+ HQ L + RD+ PD E
Sbjct: 645 KH----KALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 700
Query: 2524 -----------ILSHF----QSLSYSLAERSSLLQKAIAQSQSVQES-------LESLLQ 2561
+L +F ++ S+ RSSL + + Q Q+ E+ LE +L+
Sbjct: 701 GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLR 760
Query: 2562 SIGEVEQNLE--GKQVSSLSS-GVIQEALAT-NMKLKQDIARQKSSLEA----TREMVTR 2613
+ + LE G+ S+ +S + AL+ L+ ++S +M
Sbjct: 761 AFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALP 820
Query: 2614 FMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS--GKLQQF 2671
D +LQ + +SQ +E L Q + + L++ + +F S G+LQ +
Sbjct: 821 AEPDPDFDPNTILQTQ-DHLSQDYESLRALAQLRRARLEEAMA---LFGFCSSCGELQLW 876
Query: 2672 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---- 2727
+E K +L QP D ++ + L+ E+ L + L E+SS L
Sbjct: 877 LE-KQTVLLQRVQPQADT------LEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRY 929
Query: 2728 --DLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI 2785
+ Q Q + + L + + +L+ +E+ + E V +F + T+ +
Sbjct: 930 PGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVE--------VCSFLQECGPTQVQL 981
Query: 2786 PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2845
+ A + + +L A K TLV E L+++++++ P
Sbjct: 982 RDVLLQLEALQPGSSEDTCHAL--QLAQKKTLVLERRVH--FLQSVVVKVEEP------- 1030
Query: 2846 SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV 2905
GY + L + E L G+L + QE + R E
Sbjct: 1031 --------------GYAESQPLQG----------QVETLQGLLKQVQEQVAQRARRQAET 1066
Query: 2906 H------KEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2959
+E+ +L W ES + L+S + + + + + + ++ ++
Sbjct: 1067 QARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL 1126
Query: 2960 QKVKEALAGLLVTYPNSQEAENWKKIQ----EELNSRWERATEVTVARQRQLEESASHLA 3015
+ +A L P+SQE N ++ +EL WE+ + + +L++ +
Sbjct: 1127 DAQSQPMAAL--DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQ-WLQEGLELQKFGREVD 1183
Query: 3016 CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEF----EARRQQHEQ 3071
F A + + WL L V LS L Q ++ +L EA R E+
Sbjct: 1184 GFTATCANHQAWLHLDNLGEDVREALS-----LLQQHREFGRLLSTLGPRAEALRAHGEK 1238
Query: 3072 LNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL 3131
L ++ + V+++LQSI +W +L RS Q + ++ S Q QE
Sbjct: 1239 LVQSQHP----------AAHTVREQLQSIQAQWT----RLQGRSEQRRRQLLASLQLQEW 1284
Query: 3132 LQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELS 3191
QD++E ++ + ++ + + +P ++ + +T + HE E++ L
Sbjct: 1285 KQDVAELMQWMEEKGLMAAH---EPSGARRNILQTLK--------RHEAAESELLATRRH 1333
Query: 3192 VLIGEQYLKDELKKR---LETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 3248
V +Q ++ L +R E + LQGL + +NR Q ++L
Sbjct: 1334 VEALQQVGRELLSRRPCGQEDIQTRLQGLRS-KWEALNRKMTERGDELQQAGQQEQLLRQ 1392
Query: 3249 LDDKQSQQAKNCPISAKLERLQSQLQENEEFQ--KSLNQHSGSYEVIVAEGESL------ 3300
L D + Q LE+L+ LQ +E Q +S + ++ + +E +L
Sbjct: 1393 LQDAKEQ----------LEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAA 1442
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW-HVEDL-VPW 3358
L S+ G L E + H L R + +Q+ H+ ++ + W
Sbjct: 1443 LASMAHGMAASPAI--LEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
Query: 3359 IEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED 3418
+ + S T +S + K + EV+ + ++ + S+ L S
Sbjct: 1501 VAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQ 1560
Query: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVEGAKHQLEI 3475
I ++ Q ++ EL+ + + Q+ FQ+ F ++ E VE + +
Sbjct: 1561 HIVEQC----QELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSS 1616
Query: 3476 FDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEV 3535
D +A + + + K +A QE L ++ L Q L ++ Q V
Sbjct: 1617 RDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--------GPEVPEQQRV 1668
Query: 3536 AQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE---MFSQLADLDDELDGMGAIGRDT 3592
Q+ E + + + +LEG + H +RE + LA G ++G D
Sbjct: 1669 VQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDP 1728
Query: 3593 DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3652
+ F +++ + + A +LE + + +R+ + L +L
Sbjct: 1729 EHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD-LQTAWSEL 1787
Query: 3653 TERGKARQEQL---ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3709
E +AR L E TL D L T E+A +L V ++ + QL
Sbjct: 1788 WELTQARGHALRDTETTLRVHRDLLEVL------TQVQEKATSLPNNVARDLCGLEAQLR 1841
Query: 3710 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3769
+ ++E V + +LQ++ G +Q ++ + + W L +++ Q
Sbjct: 1842 SHQGLERELVGT-ERQLQELLETA-GRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQ 1899
Query: 3770 RIAQLQEALLHCGKFQDALEPLLSWLA----DTEELIANQKPPSAEYKVVKAQIQEQKLL 3825
R AQL+ A L +F+ A+ SW A D + ++Q+P S K+ Q +L
Sbjct: 1900 RRAQLERARL-LARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELE 1958
Query: 3826 QRLLDDRKATVDMLQAEGGRIAQSAELA---DREKITGQLESLESRWTELLSKAAARQKQ 3882
R + L + ++ Q A LA +++ +L +L+ + ++ A +Q++
Sbjct: 1959 AR---------EKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
Query: 3883 LEDILVLAKQ----FHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3938
L+ A+Q F + + L+ E L S +G+ +++Q I +H+ + +
Sbjct: 2010 LQ-----AEQQEQLFLRECGRLEEILAAQEVSLKTSA-LGSSVEEVEQLIRKHEVFLKVL 2063
Query: 3939 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRK-----AALLD 3993
A D +A + + L +L P + +++ L R +++ + A+LL
Sbjct: 2064 T--AQDKKEAA-LRERLKTLRRPR----VRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
Query: 3994 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 4053
+ + A ED ++ W ++++ + ++D + +L H A E+ ++
Sbjct: 2117 ASFTQAATQAEDWIQA--WAQQLKEPVPPGDLRDKLKPLLK-----HQAFEAEVQAHEEV 2169
Query: 4054 VDQAIKNGQALLKQT---TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 4110
+ K G+ALL Q+ GE + ++L G++ + D+ + + LE R +
Sbjct: 2170 MTSVAKKGEALLAQSHPRAGE----VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL-E 2224
Query: 4111 FQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVS 4170
F + W++E E ++ G E Q ++R +E + + + +S
Sbjct: 2225 FLQRVDLAEAWIQEKEVKMNV-GDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
Query: 4171 RALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 4230
L+L E K++ Q + R + R QQ + A
Sbjct: 2284 DLSLQLKNRDPEEV--KIICQRRSQ-------LNNRWASFHGNLLRYQQQLEGA------ 2328
Query: 4231 VAETKRKLMALGPIRLEQDQTTAQLQVQKAF--SIDIIRHKDSMDELFSHRSEIFGTCGE 4288
+ + + E D T ++Q ++A ++D + +S+ L E+ E
Sbjct: 2329 --------LEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEEL-----E 2375
Query: 4289 EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW-------ETYEELSPWIE 4341
+ +Q + ESL ++ + + E L Q V + W + E +
Sbjct: 2376 REVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALH 2435
Query: 4342 ETRALIAQLPSPAIDHEQLRQQQE---------EMRQLRESIAEHKPHIDKLL------- 4385
+ + L A L + ++LR Q + E R++ E E K +D
Sbjct: 2436 QAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLAR 2495
Query: 4386 KIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIE 4445
G QL + + E + ++ ++ L L +A+ ++
Sbjct: 2496 STGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMER 2555
Query: 4446 PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGR 4505
+ ++L+S PL P E + +K +LE AL+ G
Sbjct: 2556 WLCSKEDSLASEGLWDPLAPME-----PLLWKHKMLEWDLEVQAGKISALEATAR---GL 2607
Query: 4506 SQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK 4565
QG + A+ + M+ E + +A R + L+ L + F D + ++
Sbjct: 2608 HQGGHPE--AQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAFLQDSQEVAAWLR 2664
Query: 4566 DTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDG-LHEELEFIRILGADLIFACGETEK 4624
+ + LE +D +++ Q++ + + E D +H++ E R + G
Sbjct: 2665 EKNLVA--LEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQR--EGQRLLQGGHPAS 2720
Query: 4625 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4684
+++ ++E+ W L ++++ KL+ A +A ++ + +++ + +WL+ ++L P
Sbjct: 2721 EAIQERLEELGALWGELQDNSQKKVAKLQKACEA-LRLRRSMEELENWLEPIEVEL-RAP 2778
Query: 4685 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTEL 4744
VG L V + L +E + V ++ + E L Q + +++ + E L
Sbjct: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREG--HCLAQDVEEQARRL 2836
Query: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4804
+++L E + R+ LE L L F+ A EE M+W+ L AQ V
Sbjct: 2837 LQRFKSLREPLQERRTALEARSLLLKFFRDADEE-MAWVQEKLPLAAAQDYGQSLSAVRH 2895
Query: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
++ +H L++++ +H+A V G +L++ AG A+ + A Q E +
Sbjct: 2896 LQ-EQHQNLESEMSSHEALTRVVLGTGYKLVQ--AGHFAAH---EVAARVQQLEKAMAHL 2949
Query: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4924
+ + LQQAQ E + FL EL S L+ H+
Sbjct: 2950 RAEAARRRLLLQQAQ----EAQQFLTELLEAGSWLAERG---------------HVLDSE 2990
Query: 4925 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVSSKMEERKSKL 4981
+ E LL RL RD + E Q+ ALLE + + S K+ + +
Sbjct: 2991 DMGHSAEATQALLR--RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV 3048
Query: 4982 EEA----LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ-----IEEHKVF 5032
EA L A + LQE + L ++L + + + T SQ +E KV
Sbjct: 3049 REAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVL 3108
Query: 5033 ANEVNAHRDQIIELDQTG-NQLKFLSQKQD------VVLIKNLLVSVQSRWEKVVQRSIE 5085
+ +A R ++ L Q L+ L+ + I+ +++ WE++ Q
Sbjct: 3109 EEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKA 3168
Query: 5086 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTL 5145
R +L A + F +A +L +++ + + E + + ++ +H+ ++ L
Sbjct: 3169 RTENLAAAHE-VHSFQQAAAELQGRMQEKTALMKGE-DGGHSLSSVRTLQQQHRRLEREL 3226
Query: 5146 GGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
+ R E L + L +V++ W T+ K+ ER L +A
Sbjct: 3227 EAMEK------EVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ 3280
Query: 5206 FSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL 5265
F+ Q L+ W + + +LA + + D+ L+ H+ +E+ + Q L
Sbjct: 3281 -GHAFLGRCQELLAWAQERQ-ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDL 3338
Query: 5266 KRSGRELIENSRDDTTWV-------KGQLQELSTRWD---TVCKLSVSKQSRLEQALKQA 5315
++ G++L++NS + V +G+LQEL W C S Q +L Q L+QA
Sbjct: 3339 RQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQ-KLRQRLEQA 3397
Query: 5316 EVF 5318
E +
Sbjct: 3398 EAW 3400
Score = 157 bits (396), Expect = 4e-37
Identities = 402/1996 (20%), Positives = 771/1996 (38%), Gaps = 224/1996 (11%)
Query: 3690 AEALQWVVGTEVEI-----------INQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ 3738
A+ L+W+ ++++ + Q LA F +F+ ++ P +LQQ G + L+
Sbjct: 281 ADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPP---RLQQ-RGAAEALLF 336
Query: 3739 SAGKDCDVQG----LEHD---MEEINARWNTL-------NKKVAQRIAQLQEALLHCGKF 3784
Q L H+ + E++ W L ++ + QR+ QLQ +F
Sbjct: 337 RLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRF 396
Query: 3785 QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGG 3844
Q S+L D E+++ + P A V+A +Q +L+ + ++ L AE
Sbjct: 397 QHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQAL-AEIA 455
Query: 3845 RIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFL 3904
I + + + + E + RW LL ++KQ+ D+ + E
Sbjct: 456 DILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLE 515
Query: 3905 SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV-HQAVKIGQSLSSLTSPAE 3963
+ E A S G Q A++ + + RH LE + H V H A + + SSL + E
Sbjct: 516 ELQEP--ARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVE 573
Query: 3964 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 4023
VL K +L + + ALL+Q L A E E WL E ++ +
Sbjct: 574 --VLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEA-WLKECGQRVGNA 630
Query: 4024 FV-KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL------LKQTTGEEVLLI 4076
+ +D Q Q H AL E+ + ++ G+ L + GE +
Sbjct: 631 ALGRDLSQIAGALQK--HKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAV 688
Query: 4077 QEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL--ATSGG 4134
Q ++TR AL L+ A E WLRE L A+ G
Sbjct: 689 QGGWQLLQTRVVGRGARLQTALLVLQYFADAA--------EAASWLRERRSSLERASCGQ 740
Query: 4135 QSPTGEQIPQ-------------FQQRQKELKKEVMEHRLVLDTVNEV----SRALLELV 4177
E + + + R+ E + R L TVN +L
Sbjct: 741 DQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPG 800
Query: 4178 PWRARE------GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 4231
PW K+ A +TI Q D + + + Q A L
Sbjct: 801 PWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEA 860
Query: 4232 AETKRKLMALGPIRLEQDQTTAQLQ-VQ-KAFSIDI--IRHKDSMDELFSHR---SEIFG 4284
+ G ++L ++ T LQ VQ +A ++++ +++++ + L + +E+
Sbjct: 861 MALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSS 920
Query: 4285 TCGEEQK------TVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 4338
+ + ++ T +Q + E L Q++ + L E+ +L + V V F +E P
Sbjct: 921 SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHS-VEVCSF---LQECGP 976
Query: 4339 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398
+ R ++ QL + + ++ Q + + E + H L + +++E E
Sbjct: 977 TQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHF--LQSVVVKVEEPGYAE 1034
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 4458
+ ++ + + + + Q++E+V QRA +A +Q+ Q F + + +L E++ ++L
Sbjct: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARR--QAETQARQ--SFLQESQQLLLWAESVQAQL 1090
Query: 4459 RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-AKE 4517
R + +V + + +++ E+ Q + L + + + A D ++E
Sbjct: 1091 RSKE-VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM------AALDCPDSQE 1143
Query: 4518 IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP 4577
+ + L + +++K E+R+ + LEL +KF ++ T + Q +H L++
Sbjct: 1144 VPNTLRVLGQQGQELKVLWEQRQQWLQEGLEL-QKFGREVDGFTATCANHQAWLH-LDNL 1201
Query: 4578 GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILG-----ADLIFACGE----TEKPE-- 4626
G E ++E L + EF R+L A+ + A GE ++ P
Sbjct: 1202 G-------------EDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
Query: 4627 -VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685
VR+ + + W L ++R +L ++Q QD + M W++ + + P
Sbjct: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELM-QWMEEKGL-MAAHEP 1306
Query: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIREPLTEL 4744
G N ++ L + + E+ + +E L G EL+ ++ + D I+ L L
Sbjct: 1307 SGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED---IQTRLQGL 1362
Query: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA-QRPISGDPKVI 4803
+ WE L K+ R +L+ A GQ + L +L E+L A Q +G
Sbjct: 1363 RSKWEALNRKMTERGDELQQA----GQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRS 1418
Query: 4804 EVELAKHHV-LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4862
L K H L+++ A + + + + S A + + R + Q ++
Sbjct: 1419 SQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAI-- 1476
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD----- 4917
R QLQ++++ Q H L+ ME A G P + E L+
Sbjct: 1477 ----RGLQLQASVELHQFCH---------LSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
Query: 4918 --THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVAL----LEQKWHVVS 4971
H EL ++KA + ++L GR + + SG Q + LE W +
Sbjct: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSL------AASGHPQAQHIVEQCQELEGHWAELE 1577
Query: 4972 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVLSQIEEH 5029
E R L++A+ F + + E W+ E+ + S + L I +H
Sbjct: 1578 RACEARAQCLQQAVTFQQYFLD-VSELEGWV---EEKRPLVSSRDYGRDEAATLRLINKH 1633
Query: 5030 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRS 5089
+ E+ + + ELDQT L + +++ L + + + + + R R
Sbjct: 1634 QALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERL---REQLRALQELAATRDRE 1690
Query: 5090 LDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG-GK 5148
L+ + + EA + L WL + + DP+ +K +FQ + G
Sbjct: 1691 LEGTLRLHEFLREA-EDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
Query: 5149 QPVYDTTIRTGRALKE-KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFS 5207
Q V + L+ + P Q+ +++ W + + R H L +
Sbjct: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQ----DLQTAWSELWELTQARGHALRDTETTL 1805
Query: 5208 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKEL-GKRTGTVQVLK 5266
D L+ L E + V DL + + +H+ ++EL G ++L+
Sbjct: 1806 RVHRDLLEVLTQ---VQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLE 1862
Query: 5267 RSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLL 5326
+GR V+ + Q ++ W + + ++++LE+A A FR V
Sbjct: 1863 TAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR-FRTAVRDYA 1921
Query: 5327 EWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHP 5386
W + Q L+ + + + L H+ ++E + A +G+ L
Sbjct: 1922 SWAARVRQDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
Query: 5387 DCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAEL--LEELLAWIQWAETT 5444
+ + R + TWA++ Q+RL+ E + E LEE+LA + + T
Sbjct: 1981 PTKEVQEELRALQDQRDQVYQTWARK-QERLQAEQQEQLFLRECGRLEEILAAQEVSLKT 2039
Query: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMT---RKQPDVDRVTKTYKRKNIEPTHAPFI 5501
+ +++ V+ LI +H+ F++ +T +K+ + KT +R + P +
Sbjct: 2040 ------SALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRD-RLPIL 2092
Query: 5502 EKSRSGGRK---SLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5558
+ R ++ S + + S ++A + W Q W L+ D
Sbjct: 2093 LQRRMRVKELAESRGHALHASLLMASFTQAATQ-----AEDWIQAWAQQLKEPVPPGDLR 2147
Query: 5559 DRLEELKEFANFDFDV 5574
D+L+ L + F+ +V
Sbjct: 2148 DKLKPLLKHQAFEAEV 2163
Score = 144 bits (363), Expect = 3e-33
Identities = 378/1897 (19%), Positives = 746/1897 (39%), Gaps = 238/1897 (12%)
Query: 3743 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3802
D D + + ++ + +L R A+L+EA+ G F + L WL L+
Sbjct: 826 DFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFG-FCSSCGELQLWLEKQTVLL 884
Query: 3803 ANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL------ADRE 3856
+P + +V+ Q++ + L L A L AE ++ SAE +
Sbjct: 885 QRVQPQADTLEVM--QLKYENFLTAL-----AVGKGLWAE---VSSSAEQLRQRYPGNST 934
Query: 3857 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3916
+I Q E L RW +L + + QL + + F + P L +L +P
Sbjct: 935 QIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCS-FLQECGPTQVQLRDVLLQLEALQP 993
Query: 3917 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQA 3976
++ Q+ + K L + H VK+ + AE L ++++LQ
Sbjct: 994 GSSEDTCHALQLAQKKTLVLERRVHFLQ-SVVVKVEEP-----GYAESQPLQGQVETLQG 1047
Query: 3977 RYSEIQDRCCRKAALLDQALSNARL-FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 4035
++Q++ ++A QA + AR F ++ ++L W V+ +L
Sbjct: 1048 LLKQVQEQVAQRARR--QAETQARQSFLQESQQLLLWAESVQAQL--------------- 1090
Query: 4036 QHADHLALNEEIVNRKKNVDQAIKNGQALLK--QTTGEEVLLIQEKLDGIKTRYADITVT 4093
R K V + + Q LL+ Q EE+ L QE+L + + +
Sbjct: 1091 --------------RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAAL 1136
Query: 4094 ----SSKALRTLEQARQLATKFQSTYEELTGWL----------REVEEELATSGGQSPTG 4139
S + TL Q + + +E+ WL REV+ AT
Sbjct: 1137 DCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANH---- 1192
Query: 4140 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA---REGLDKLVSDANEQY 4196
Q L ++V E +L E R L L P RA R +KLV +
Sbjct: 1193 ----QAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP-RAEALRAHGEKLVQSQHPAA 1247
Query: 4197 KLVSDTIG--------------QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALG 4242
V + + QR ++ A++Q Q+++Q + W+ E K + A
Sbjct: 1248 HTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL-QEWKQDVAELMQWMEE-KGLMAAHE 1305
Query: 4243 PIRLEQD--QTTAQLQVQKAFSIDIIRHKDSMD----ELFSHRSEIFGTCGEEQKTVLQE 4296
P ++ QT + + ++ + RH +++ EL S R CG+E +Q
Sbjct: 1306 PSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRP-----CGQED---IQT 1357
Query: 4297 KTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAID 4356
+ + L ++EA++ +ER L++A E+L +++ + + QL
Sbjct: 1358 RLQGLRSKWEALNRKMTERGDELQQAG--------QQEQLLRQLQDAKEQLEQLEGALQS 1409
Query: 4357 HE---QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMY 4413
E LR Q ++ ++ +E + K+ + + + E+ QK
Sbjct: 1410 SETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPA--ILEETQKHLRRL 1467
Query: 4414 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 4473
++ + R L L +V E H L +E MP P E
Sbjct: 1468 ELLQGHLAIRGLQLQASV-------ELHQFCH--LSNMELSWVAEHMPHGSPTSYT---E 1515
Query: 4474 CISDNKSATVELEKLQPSFEALKRRGEELI--GRSQGADKDLAAKEIQDKLDQMVFFWED 4531
C++ +S + ++LQ +A + + + ++ GRS A A+ I ++ ++ W +
Sbjct: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
Query: 4532 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAA 4591
++ RA E + L ++++ D++ L +++ + +V + G D + + +
Sbjct: 1576 LE-RACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY-GRDEAATLRLINKH 1633
Query: 4592 ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE- 4650
+ ++EE +E + L ++ V++ + E A + L T LE
Sbjct: 1634 QALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEG 1693
Query: 4651 --KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVY 4708
+L + ++ A Q WL + +G D + +F+ +V
Sbjct: 1694 TLRLHEFLREAEDLQG-------WLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746
Query: 4709 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4768
+ E +L++ + ++R+ +L+ W L E R H L
Sbjct: 1747 MGSQRVAACRLLAESLLERG--HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETT 1804
Query: 4769 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
L + LE L E+ ++ D +E +L H L+ +++ + ++ +
Sbjct: 1805 LRVHRDLLEVLTQV---QEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861
Query: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888
+ + + G A +++ R +A+ Q W + ++ E+R QL+ A+ F + + D+
Sbjct: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR-FRTAVRDY 1920
Query: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4948
R+ L + + P + +L H L ++L+A+E+ + Q G+ LL+
Sbjct: 1921 ASWAARVRQDLQVEE-SSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLA-- 1977
Query: 4949 DSGSGSK--TEQSVALLEQKWHVVSS---KMEERKSKLEEALNLATEFQNSLQEFINWLT 5003
+G+ +K E+ AL +Q+ V + K E +++ +E L F L
Sbjct: 1978 -AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQL-----FLRECGRLEEILA 2031
Query: 5004 LAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVV 5063
E SL ++ S + V I +H+VF + A + L + +LK L + +
Sbjct: 2032 AQEVSLKTSALGSSV-EEVEQLIRKHEVFLKVLTAQDKKEAALRE---RLKTLRRPR--- 2084
Query: 5064 LIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE 5123
+++ L + R +V + + RG +L + A F +A + DW++ L +
Sbjct: 2085 -VRDRLPILLQRRMRVKELAESRGHALHASLLMA-SFTQAATQAEDWIQAWAQQLKEPVP 2142
Query: 5124 ISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--KEKTLLPEDSQKLDNFLGE 5181
+ DK+K L KH+ F+ + + V + + G AL + E SQ+L
Sbjct: 2143 PGDLRDKLK-PLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG---- 2197
Query: 5182 VRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLV 5241
+R W+ + R +LE+ F +F+ + W+ + E ++ + DL+
Sbjct: 2198 LRKHWEDLRQAMALRGQELEDRRNFL-EFLQRVDLAEAWIQEKEVKMNVGD-LGQDLEHC 2255
Query: 5242 MNLMDAHKVFQ-KELGKRTGTVQVLKRSGRELIENSRD--DTTWVKGQLQELSTRWDTVC 5298
+ L + F+ G G + S L +RD + + + +L+ RW +
Sbjct: 2256 LQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFH 2315
Query: 5299 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL------PDDTEALQSL 5352
+ Q +LE AL+ +H+L L + ++ + AL D E++Q L
Sbjct: 2316 GNLLRYQQQLEGALE--------IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRL 2367
Query: 5353 IDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCH--PDCITTIKHWITIIRARFEEVLTWA 5410
+ H+E ++V + V S + + +C P+ ++H + + ++ + A
Sbjct: 2368 LRKHEELEREVHPIQAQVES---LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRA 2424
Query: 5411 KQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTF 5470
++ ++ L+ AL + +L+ELL A+ Q D P P++ + ++ EHQ
Sbjct: 2425 QKRREALD-ALHQAQKLQAMLQELLV---SAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
Query: 5471 MEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKN 5530
E+ D T + I +RS G++ L+ P I
Sbjct: 2481 KAEL-------DSWTDS-------------ISLARSTGQQLLTAGHPFSSDIRQVLAGLE 2520
Query: 5531 PRINQLSARWQQVWLLALERQRKLNDALDRLEELKEF 5567
++ L WQ+ L L++ +L L +E+++ +
Sbjct: 2521 QELSSLEGAWQE-HQLQLQQALELQLFLSSVEKMERW 2556
Score = 107 bits (268), Expect = 3e-22
Identities = 310/1473 (21%), Positives = 565/1473 (38%), Gaps = 162/1473 (10%)
Query: 1816 LLRNIEMRTKQIQPLELNLAELQDLLCQAKVLER-ELKDLTTLVSQELECVNQIIISQPQ 1874
L+R E+ K + + A L++ L K L R ++D ++ Q V ++ S+
Sbjct: 2052 LIRKHEVFLKVLTAQDKKEAALRERL---KTLRRPRVRDRLPILLQRRMRVKELAESRGH 2108
Query: 1875 EVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEI-EKTKVLNQHTQLEGRLQ- 1932
+ A LL A A + W +L ++ +K K L +H E +Q
Sbjct: 2109 ALHASLLMASFTQAATQAEDWIQA---WAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
Query: 1933 --DLRAWVGNKN--LILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQ 1988
++ V K L+ S E+ L + +EDL+Q MA R +L+ ++
Sbjct: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVS-QRLQGLRKHWEDLRQAMALRGQELEDRRNFLE 2224
Query: 1989 FFISEHAQDLSPQ--QNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKT 2046
F DL+ Q +++ + +L + + L+ + +A +++
Sbjct: 2225 FL---QRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRS 2281
Query: 2047 LQ----KQQNTCHQQLEDLCSWVGQAERALAGHQGRTT--QQDLSALQKNQSDLKDLQDD 2100
+ + +N ++++ +C Q A G QQ L + ++L D+
Sbjct: 2282 ISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSREL-DN 2340
Query: 2101 IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE 2160
+ R +++ ++ + + R+ L ++H + Q E+L+ E +
Sbjct: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
Query: 2161 EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLE 2220
EA ++ E +++ +L +K LD + L E L A
Sbjct: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML------QELLVSAQRL 2454
Query: 2221 KGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLT 2280
+ +DT+ +A L++ E EL S + LA + Q L GH +
Sbjct: 2455 RAQMDTSPAPRSPVEARRMLEEHQECKA----ELDSWTDSISLARSTGQQLLTA-GHPFS 2509
Query: 2281 PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL 2340
+ +Q+L G +E S A E +L+ Q L ELQ FL ++ E WL E L
Sbjct: 2510 SDIRQVLA---GLEQELSSLEGAWQEHQLQLQQAL--ELQLFLSSVEKMERWLCSKEDSL 2564
Query: 2341 ENMHKGGSSP-ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSE 2399
+ +G P + LL + D+ G + + + + +G P
Sbjct: 2565 AS--EGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATAR-------GLHQGGHPEA 2615
Query: 2400 IGNLVKDKLKDATERYTALHSKC-TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVE 2458
L + + R AL + TR H L Q F + + AW++ E N+
Sbjct: 2616 QSAL--GRCQAMLLRKEALFRQAGTR--RHRLEELRQLQAFLQDSQEVAAWLR--EKNLV 2669
Query: 2459 KLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ 2518
L + D +L QL + Q EL ++LQ+ + +++ G PA + +Q
Sbjct: 2670 ALEEGLL--DTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQ-GGHPASE--AIQ 2724
Query: 2519 ETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSL 2578
E + + + + L + ++ + LQKA ++ ++ S+E L + +E L V
Sbjct: 2725 ERLEELGALWGELQDNSQKKVAKLQKA-CEALRLRRSMEELENWLEPIEVELRAPTVGQA 2783
Query: 2579 SSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE 2638
GV E L T +L+ + ++ EA F+ A ++ + + QRF+
Sbjct: 2784 LPGV-GELLGTQRELEAAVDKKARQAEALLGQAQAFVREG-HCLAQDVEEQARRLLQRFK 2841
Query: 2639 QLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQE 2698
L QE+ ++L+ + F ++ +++ K + A+ QD ++
Sbjct: 2842 SLREPLQERRTALEARSLLLKFFRDADEEM-AWVQEKLPLAAA-----QDYGQSLSAVRH 2895
Query: 2699 LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQH------QDRVQNLRKDFTELQKTVKE 2752
L + ++ + + + E L + G+ L H RVQ L K L+
Sbjct: 2896 LQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAAR 2955
Query: 2753 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812
R QE +L+ WL E + + SA+ + + L++ D
Sbjct: 2956 RRLLLQQAQEAQQFLTELLEA-GSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLE 3014
Query: 2813 SKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQC 2872
+ +E + LE+ P+S P V + + +V H
Sbjct: 3015 AFSPRIERLQQTAALLESR----KNPES--------PKVLAQLQAVREAH---------- 3052
Query: 2873 DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP 2932
+++ + E G H QE LQ + ++ +E + WL +K +S D
Sbjct: 3053 --AELLRRAEARG---HGLQEQLQ-----LHQLERETLLLDAWLTTKAATAESQDYGQD- 3101
Query: 2933 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLV-----TYPNSQEAENWKKIQE 2987
E VK E AF E++ LAG L YP+ Q +
Sbjct: 3102 --LEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQ------RS 3153
Query: 2988 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEK-ELMMGVLGPLSIDP- 3045
+ + WER + AR L +A + FQ A ++L+ + EK LM G G S+
Sbjct: 3154 RIEAAWERLDQAIKARTENL-AAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSV 3212
Query: 3046 NMLNAQKQQVQFMLK--EFEARRQQHE-----QLNEAAQGILTGPGDVSLSTSQVQKELQ 3098
L Q ++++ L+ E E R Q E QL+ AA G G V + + +Q + Q
Sbjct: 3213 RTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPG---GLAKVQEAWATLQAKAQ 3269
Query: 3099 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELL--QDLSEKVRAVGQRLSVQSAISTQP 3156
Q W+ + ++ + + + + + QEL ++L+E V Q L Q
Sbjct: 3270 ERGQ-WLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLG-------QH 3321
Query: 3157 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQG 3216
E + Q++ E DL Q E Q L D ++ E+ + L+ + LQ
Sbjct: 3322 EELGQEIRECRLQAQDLRQ------EGQQLVD------NSHFMSAEVTECLQELEGRLQE 3369
Query: 3217 LEDLAADRINRLQAALASTQQFQQMFDELRTWL 3249
LE+ A R R A Q+ +Q ++ WL
Sbjct: 3370 LEEAWALRWQRC-AESWGLQKLRQRLEQAEAWL 3401
Score = 79.7 bits (195), Expect = 8e-14
Identities = 264/1272 (20%), Positives = 486/1272 (38%), Gaps = 175/1272 (13%)
Query: 4300 SLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIA--QLPSPAIDH 4357
S + Q + + ++ +L+ ++L Q+ + +L WI E + + P
Sbjct: 247 SRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAM 306
Query: 4358 EQL-------RQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN-----PEEGEMVEEK 4405
QL R Q++ R + AE L ++ L+ N P EG + E
Sbjct: 307 RQLLAAFTIFRTQEKPPRLQQRGAAEAL-----LFRLQTALQAQNRRPFLPHEGLGLAEL 361
Query: 4406 YQ---KAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 4462
Q E A + ++QR L L + + + E L+ E + + R PP
Sbjct: 362 SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
Query: 4463 LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL 4522
ATVE A++R G G + A EI D L
Sbjct: 422 A---------------SLATVEA--------AVQRLGMLEAGILPQEGRFQALAEIADIL 458
Query: 4523 DQMVFF-WEDIKARAEEREIKF---LDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-- 4576
Q + W D+ R EE +++ L L+ K DM A+L+ +++ + H LE
Sbjct: 459 RQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQ 518
Query: 4577 -PGIDPSIIKQQVEAAETIKEETDGLHEELEF-IRILGADLIFACGETEKPE-------- 4626
P + +Q E E ++ H+ LE + GA + +T + +
Sbjct: 519 EPARSTACGQQLAEVVELLQR-----HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVE 573
Query: 4627 -VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685
++ + ++L + R LE +Q A ++ + WL ++
Sbjct: 574 VLQAKARTLAQLQQSLVALVRARRALLEQTLQRA-EFLRNCEEEEAWLKECGQRVGNAA- 631
Query: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIREPLTEL 4744
+G DL+ + L + K + EV++ Q L +G +L ++ + D E +
Sbjct: 632 LGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPG---ERAEAV 688
Query: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4804
+ W+ L ++ R +L+ ALL L F A E SWL L +R G +
Sbjct: 689 QGGWQLLQTRVVGRGARLQTALLVLQYFADA-AEAASWLRERRSSL--ERASCGQDQAAA 745
Query: 4805 VELAKHHVLKNDVL-----------------AHQATVETVNKAGNELLESSAGDDASSLR 4847
L + HV VL + +A++ TVN A + ES S
Sbjct: 746 ETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEA 805
Query: 4848 SRLEAMNQCWE--------------SVLQKTEEREQQLQSTLQQAQGFHSEIED----FL 4889
S W+ ++LQ + Q +S AQ + +E+ F
Sbjct: 806 SCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFG 865
Query: 4890 LELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDD 4949
+ E QL K T L + + Q DT ++ K E + L G+ +
Sbjct: 866 FCSSCGELQLWLEKQT-VLLQRVQPQADT----LEVMQLKYENFLTALAVGKGLWAEVSS 920
Query: 4950 S---------GSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFIN 5000
S G+ ++ ++ L Q+W + + E+ +L ++ + + Q +
Sbjct: 921 SAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQ 980
Query: 5001 WLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH--RDQIIELDQTGNQLKFLSQ 5058
+ Q L P S Q+ + K E H + ++++++ G Q
Sbjct: 981 LRDVLLQ-LEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQ 1039
Query: 5059 KQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL 5118
Q V ++ LL VQ E+V QR+ R ++ AR + F + ++L+ W E ++ L
Sbjct: 1040 GQ-VETLQGLLKQVQ---EQVAQRA--RRQAETQAR---QSFLQESQQLLLWAESVQAQL 1090
Query: 5119 DSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 5178
S+ E+S D + L +H++ + + Q + + L DSQ++ N
Sbjct: 1091 RSK-EVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPM--AALDCPDSQEVPNT 1147
Query: 5179 LGEVRDKWDTVCGKSVERQHKLEEALLFS--GQFMDALQALV----DWLYKVEPQLAEDQ 5232
L + + + +RQ L+E L G+ +D A WL+ L E
Sbjct: 1148 LRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL--DNLGE-- 1203
Query: 5233 PVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELST 5292
D+ ++L+ H+ F + L + L+ G +L+++ V+ QLQ +
Sbjct: 1204 ----DVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQA 1259
Query: 5293 RWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSL 5352
+W + S ++ +L +L Q + ++ V L++W+ E + A + + A +++
Sbjct: 1260 QWTRLQGRSEQRRRQLLASL-QLQEWKQDVAELMQWMEE-----KGLMAAHEPSGARRNI 1313
Query: 5353 IDT---HKEFMKKVEEKRVDVNSAVAMGEVILA--VCHPDCITT-----IKHWITIIRAR 5402
+ T H+ ++ R V + +G +L+ C + I T W + R
Sbjct: 1314 LQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKM 1373
Query: 5403 FEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKA 5462
E + QQ E L +L E LE+L +Q +ET R + + + R +
Sbjct: 1374 TERGDELQQAGQQ--EQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQK---RHQQ 1428
Query: 5463 LIAEHQTFMEEM 5474
L +E +T +M
Sbjct: 1429 LESESRTLAAKM 1440
Score = 72.0 bits (175), Expect = 2e-11
Identities = 214/1014 (21%), Positives = 382/1014 (37%), Gaps = 171/1014 (16%)
Query: 1875 EVPAQLLKALEKDAKNLQKS----LSSVSDTWNSRLLHFQNAVEIEKTKV--LNQHTQLE 1928
EV A + ALE A+ L + S + LL + T+ L + QL+
Sbjct: 2591 EVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQ 2650
Query: 1929 GRLQD---LRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAF 1985
LQD + AW+ KNL+ +G +D L LQ+ ++ +A+LDA
Sbjct: 2651 AFLQDSQEVAAWLREKNLVALEEGL---LDTAMLPAQLQKQQNF-------QAELDA--- 2697
Query: 1986 DIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK 2045
S H Q ++ +++L+ + + Q+ LE ++ AL G LQ Q+ + K
Sbjct: 2698 ------SMHQQQELQREGQRLLQGGHPASEAIQERLE----ELGALWGELQDNSQKKVAK 2747
Query: 2046 TLQK--QQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQN 2103
LQK + + +E+L +W+ E L + T Q L + + ++L+ +
Sbjct: 2748 -LQKACEALRLRRSMEELENWLEPIEVEL---RAPTVGQALPGVGELLGTQRELEAAVDK 2803
Query: 2104 RATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAV 2163
+A ++ + F+ E E E+ + +++++L+E
Sbjct: 2804 KARQAEALLGQAQAFVREGHCLAQDVE-----EQARRLLQRFKSLRE------------- 2845
Query: 2164 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 2223
LQ+ +A L + + D + WV EK
Sbjct: 2846 --PLQERRTALEARSLLLKFFRDADEEMAWVQ------------------------EKLP 2879
Query: 2224 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAF---LDQHGHNLT 2280
L Y A L +Q HQ L S+ + T+ L Q GH
Sbjct: 2880 LAAAQDYGQSLSAVRHLQEQ-------HQNLESEMSSHEALTRVVLGTGYKLVQAGHFAA 2932
Query: 2281 PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL 2340
E +QQ L + A+ L+Q Q Q +FL + E SWL L
Sbjct: 2933 HEVAARVQQ-LEKAMAHLRAEAARRRLLLQQAQEAQ----QFLTELLEAGSWLAERGHVL 2987
Query: 2341 ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI 2400
++ G S+ E +LL+R + D+ + + + Q+ + S K + P
Sbjct: 2988 DSEDMGHSA-EATQALLRRLEATKRDLEAFSPRIERL----QQTAALLESRKNPESPK-- 3040
Query: 2401 GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL 2460
V +L+ E + L + G L L Q HQ + L AW+ A E
Sbjct: 3041 ---VLAQLQAVREAHAELLRRAEARGHGLQEQL-QLHQLERETLLLDAWLTTKAATAESQ 3096
Query: 2461 LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2520
VL+E+ ++ + L Q V L+K+A + G P + H+Q
Sbjct: 3097 DYGQDLEGVKVLEEKFDAFRKEVQSLG--QAKVYALRKLAGTLE--RGAPR-RYPHIQAQ 3151
Query: 2521 TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2580
I + ++ L ++ KA ++ + + S Q+ E++ ++ K ++L
Sbjct: 3152 RSRIEAAWERLDQAI--------KARTENLAAAHEVHSFQQAAAELQGRMQEK--TALMK 3201
Query: 2581 GVI-QEALATNMKLKQDIARQKSSLEATREMVTRFMETAD--STTAAVLQGKLAEVSQRF 2637
G +L++ L+Q R + LEA + V R A G LA+V + +
Sbjct: 3202 GEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAW 3261
Query: 2638 EQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM--ENKSRMLASGNQPDQDIT----- 2690
L + QE+ + L QA G+ Q+ + + + LAS + +D+
Sbjct: 3262 ATLQAKAQER----GQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQL 3317
Query: 2691 -----HFFQQIQELNLEMED----QQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2741
Q+I+E L+ +D Q+ +D + E++ C +Q L
Sbjct: 3318 LGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTEC------------LQELEG 3365
Query: 2742 DFTELQKTVKEREKDASSCQEQ--LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEK 2799
EL++ R + C E L + R+ + + WL EG + + S ++E
Sbjct: 3366 RLQELEEAWALRWQ---RCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVEL 3422
Query: 2800 QI---EHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPS 2850
+ + L+ LL K +++ T +E ++ G+ GS L S
Sbjct: 3423 LLHRHQDLEKLLAAQEEKFAQMQK-----TEMEQELLLQPQELKPGRAGSSLTS 3471
Score = 68.2 bits (165), Expect = 2e-10
Identities = 175/842 (20%), Positives = 305/842 (36%), Gaps = 195/842 (23%)
Query: 1807 DEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDL-------TTLVS 1859
++ LV+ L + M Q+Q + AEL + Q + L+RE + L + +
Sbjct: 2665 EKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQ 2724
Query: 1860 QELECVNQI---IISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIE 1916
+ LE + + + Q+ A+L KA E A L++S+ + + W + A +
Sbjct: 2725 ERLEELGALWGELQDNSQKKVAKLQKACE--ALRLRRSMEEL-ENWLEPIEVELRAPTVG 2781
Query: 1917 KT-----KVLNQHTQLEG----RLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYE 1967
+ ++L +LE + + A +G + ++ + LQ+++
Sbjct: 2782 QALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFK 2841
Query: 1968 DLKQPMAERKAQLDALAFDIQFF---------ISEHAQDLSPQQNRQMLRLLNELQRSFQ 2018
L++P+ ER+ L+A + ++FF + E + Q Q L + LQ Q
Sbjct: 2842 SLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQ 2901
Query: 2019 DI----------------------------LEQTAAQVDALQGHLQQMEQEALVKTLQKQ 2050
++ + AA+V L+ + + EA + L Q
Sbjct: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQ 2961
Query: 2051 QNTCHQQ----LEDLCSWVGQAERAL----AGHQGRTTQQDLSALQKNQSDLKDLQDDIQ 2102
Q QQ L + SW+ + L GH TQ L L+ + DL+ I+
Sbjct: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIE 3021
Query: 2103 NRATSFATVVKDIEGFMEENQTKLSPRELTALR-------EKLHQAKEQYEALQEETRVA 2155
++ +E + SP+ L L+ E L +A+ + LQE+ ++
Sbjct: 3022 R--------LQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLH 3073
Query: 2156 QKELE----------EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLL 2205
Q E E +A T+ Q + + K L E K DA V S+G + L
Sbjct: 3074 QLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEE---KFDAFRKEVQSLGQAKVYAL 3130
Query: 2206 TNLPGMEQLSGASLEKGALDTTDGYMG----VNQAPEKLDKQCEMMKARHQELLSQQQNF 2261
L G +LE+GA + A E+LD + +KAR + L + +
Sbjct: 3131 RKLAG-------TLERGAPRRYPHIQAQRSRIEAAWERLD---QAIKARTENLAAAHE-- 3178
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK 2321
+ + Q A A E Q +Q+K +K + L V+TLQ
Sbjct: 3179 VHSFQQAAA-----------ELQGRMQEKTALMKGE------DGGHSLSSVRTLQ----- 3216
Query: 2322 FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 2381
Q H+ E LE EKE+ + R G
Sbjct: 3217 --QQHRRLERELEAMEKEVARLQTEAC----------RLGQL------------------ 3246
Query: 2382 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 2441
P+ G L K E + L +K G L Q H F
Sbjct: 3247 --------------HPAAPGGLAK-----VQEAWATLQAKAQERGQWLAQ-AAQGHAFLG 3286
Query: 2442 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 2501
L AW Q + E S+ +A D ++ L ++L +E+ E ++ + L++
Sbjct: 3287 RCQELLAWAQERQ---ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQ--- 3340
Query: 2502 DIMEIEGEPAPDHRH-VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
EG+ D+ H + L + L E +L + A+S +Q+ + L
Sbjct: 3341 -----EGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLE 3395
Query: 2561 QS 2562
Q+
Sbjct: 3396 QA 3397
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 203 bits (517), Expect = 4e-51
Identities = 661/3649 (18%), Positives = 1424/3649 (39%), Gaps = 486/3649 (13%)
Query: 1817 LRNIEMRTKQIQPL---ELNLAELQDLLCQAKVLERELKDLTTLVSQELECV--NQIIIS 1871
L+N+++RT +IQ N E + C R+ + T+ + +E + + N+++++
Sbjct: 2917 LKNLKIRTNRIQRFIQNTCNEVEHKIKFC------RQFHEKTSALQEEADSIQRNELLLN 2970
Query: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSD-----------------TWNSRLLH------ 1908
Q ++ K ++++ NL+ L+++ W+ L
Sbjct: 2971 Q------EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQV 3024
Query: 1909 FQNAVEIE-KTKVLNQHTQLEGRLQDLRAWVGNKNL--------ILNSKGSNSEIDVDSL 1959
F+ E+E K K L+ + G+ Q L + + +L +L + S+ E +
Sbjct: 3025 FEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNA 3084
Query: 1960 NLCLQQYEDLKQPMAERKAQLDA-LAFDIQFFISEHAQ-DLSPQQNRQMLRLLNEL---- 2013
+ Q+ E K E +L+ FD F E Q L+ ++N ++ ++L +
Sbjct: 3085 QILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLEL 3144
Query: 2014 ------QRSFQDILEQTAAQVDALQGHLQQMEQEAL-VKTLQKQQNTCHQQLEDLCSWVG 2066
+++ QD LE + ++ ++ LQQ L +K +Q +++ C E + W
Sbjct: 3145 SPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQV--WAE 3202
Query: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126
+ + ++A++K + + D++ + F + + ++ L
Sbjct: 3203 MC-----------SIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
Query: 2127 SP--RELTALREKLHQAKEQYEALQE---ETRVAQKELEEAVTSALQQETEKSKAAKELA 2181
+ LT +E + +A E +L+ RV EE++ L+++ E +
Sbjct: 3252 NDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQ 3311
Query: 2182 ENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG--YMGVNQAPEK 2239
+ +K+ + S + QL L + + A E T+ Y+ + K
Sbjct: 3312 DLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRK 3366
Query: 2240 LDKQCEMMKARHQELLSQQQNFI-LATQSAQAFLDQHG---HNL--TPEEQQMLQQKLGE 2293
+++ ++ + +L Q + + L+ + A L+Q NL T EE L+Q L
Sbjct: 3367 MEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRL 3426
Query: 2294 LKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE-------------- 2339
L+ + + + LK V L ++ L+ KE+E W E ++E
Sbjct: 3427 LRLRCTEN--DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAII 3484
Query: 2340 LENMH---------KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 2390
L+N+ K ++ E L LL + E+V + +T+ Q++ ++N
Sbjct: 3485 LDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ---LLLTLLLQRIRSIQNV 3541
Query: 2391 FKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 2450
+ + ++ ER L K + + + + H F +L+ +
Sbjct: 3542 PESSGAVETVPAF--QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFF 3599
Query: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR----DIMEI 2506
Q + + + D EQ ++LQ L + ++ E + + R ++ I
Sbjct: 3600 QQTTTSFQNM----AFQDHPEKSEQF---EELQSILKKGKLTFENIMEKLRIKYSEMYTI 3652
Query: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEV 2566
PA V+E ++ + +S + + S S +++ +E + + V
Sbjct: 3653 V--PAEIESQVEECRKALEDIDEKISNEVLKSSP--------SYAMRRKIEEINNGLHNV 3702
Query: 2567 EQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2626
E+ L+ K + I++A K+ ++ S L V +E D A
Sbjct: 3703 EKMLQQKSKN------IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQ-DPGQAQEW 3755
Query: 2627 QGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD 2686
L Q+++Q+ + + + S L K + E + L + ++EN S +LA+ D
Sbjct: 3756 MDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYD 3815
Query: 2687 --QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFT 2744
+ ++H +Q + +ED ++ + L + +L + + +Q L T
Sbjct: 3816 SLRTLSHHASTVQ---MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVT 3872
Query: 2745 ELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL-----EK 2799
LQ+ + E Q D+ V + +K E + +T + +KE+ E+
Sbjct: 3873 ALQQKIME---SLPQIQRMADD----VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE 3925
Query: 2800 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2859
++H + +L++ + EI L LP G V
Sbjct: 3926 HLKHGEVILENIRPMKKTIAEIVSYQVELR------------------LPQTGMKPLPV- 3966
Query: 2860 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919
+ L + D+ L L V E+ E L+ ++ + E +E ++ Q L +
Sbjct: 3967 -FQRTNQL------LQDIKL----LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNY 4015
Query: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN-SQE 2978
S++ MS + + Q E + L N K + + A +L + + QE
Sbjct: 4016 SAQF-SLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQE 4074
Query: 2979 AENWKKIQEELNSRWERATEVTVARQRQLEE--SASHLACFQA---------------AE 3021
E ++ + + E A +R+L S S+LA + AE
Sbjct: 4075 QEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
Query: 3022 SQLRPWL--------MEKELMMGVLGPLSIDP--NMLNAQKQQVQFMLKEFEARRQQHE- 3070
+ W ME++ G + + + + Q + + Q E
Sbjct: 4135 PSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPEC 4194
Query: 3071 --QLNEAAQGILTGPGDVSLSTSQVQKELQS-INQKWVELTDKLNSRSSQIDQ------- 3120
+ N+ +G +L +S Q L+ + + E T+ L++ +Q+ +
Sbjct: 4195 SLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
Query: 3121 ---AIVKSTQYQELLQDLSEKVRAVGQRLS-VQSAISTQPEAVKQQ-LEETSEIRSDLEQ 3175
A+ T ++ Q L +++ L+ ++ ++ E K Q L + + + E
Sbjct: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
Query: 3176 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 3235
L ++K + +++ +++ E++ +D+ L+ + P + E L ++ L++ +
Sbjct: 4315 LSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEP-EHQEALQPVNLSELESIVTER 4373
Query: 3236 QQFQQMFD-ELRTWLDDKQSQQA---KNCPISAKLERLQSQLQENEEFQKSLNQHSGSYE 3291
QF + D + + L+ K +Q K +AK Q +N+ Q+S S S +
Sbjct: 4374 PQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQES----SASNQ 4429
Query: 3292 VIVAEGE--SLLLSVPPGEEKRTLQNQLVELKNHWE-ELSKKTADRQSRLKDCMQKAQKY 3348
E + +LS P G+ Q EL + + L + + S + Y
Sbjct: 4430 ASSPENDVPDSILS-PQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMY 4488
Query: 3349 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE---VEKRRSLLEILNSA 3405
+ P E+ K ++L + ++ E+S L+++ + E + + L E+ +
Sbjct: 4489 NFRY----PTTEELKTYTTQL----EDLRQEASNLQTQENMTEEAYINLDKKLFELFLTL 4540
Query: 3406 ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKK 3465
+ L + E E + G Q + T L+ K L ++ + K +
Sbjct: 4541 SQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKK----GDLLKAMTWP 4596
Query: 3466 VEGAKHQLEIFDAL--------GSQACSNKNLEK----LRAQQEVLQALEPQVDYLRNFT 3513
E LE FD L + C +K+L+ R+ Q ++ L Q+ +
Sbjct: 4597 GENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSL 4656
Query: 3514 QGLVEDAPDGSDASQL---------LHQAEVAQQEFLEVKQRVNSGCVMMEN--KLEGI- 3561
Q + + S A QL L AE + + +R++ +++ KLE +
Sbjct: 4657 QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVL 4716
Query: 3562 ----GQFHCRVREMFSQL---ADLDDELDGMGA---IGRDT------------DSLQSQI 3599
G R E+ S + D L GM IG++ +LQ+QI
Sbjct: 4717 DSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQI 4776
Query: 3600 EDVRLFLNKIHVLKLDIEASEAECRHML---EEEGTLDLLGLKRELEALNKQCGKLTERG 3656
E+ ++F K+ L I+A A+ L E + + + LE ++QCG +
Sbjct: 4777 ENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL 4836
Query: 3657 KARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQK 3716
+ E+ + +E L + + EE E E + ++++ ++ K
Sbjct: 4837 LQKWEEFDENYASLEKDLEILISTLPSVSLVEETE----------ERLVERISFYQQI-K 4885
Query: 3717 EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQE 3776
+ +L Q G+ L+ S LE + ++ +W +LNKK+ + +LQ
Sbjct: 4886 RNIGGKHARLYQTLNEGKQLVASVS----CPELEGQIAKLEEQWLSLNKKIDHELHRLQA 4941
Query: 3777 ALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQRLLDDR 3832
L H + + L WL ++ + K S + +++ I + +D++
Sbjct: 4942 LLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEK 5001
Query: 3833 KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ 3892
+ + + G ++ E D + L E +WT L+++ Q++L + +
Sbjct: 5002 SSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
Query: 3893 FHETAEPISDFLSVTEKKLANSEPVGTQTA--KIQQQIIRHKA--LEEDIENHATD-VHQ 3947
+ + +++ E + ++ + V + ++ +++ + +HK +E D + D V+Q
Sbjct: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ 5120
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
++ + + E+ +E + + ++ + RK L+Q L + E+++
Sbjct: 5121 SLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE-SENKI 5179
Query: 4008 EVLN-WLAEVEDKLSSV----FVKDFKQDVLHRQHADH-LALNEEIVNRKKNVDQAIKNG 4061
++LN WL E++L ++ V ++ +L Q ++ LA+ + ++ K +++G
Sbjct: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
Query: 4062 QALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 4121
L + T + + +K + T+ + + L+ + QL Y+E+
Sbjct: 5240 AVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQL-------YDEVNMM 5292
Query: 4122 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA 4181
+ S + E + + + L+ E + + EV L L P A
Sbjct: 5293 TIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVA 5352
Query: 4182 REGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241
E +++ + ++++ V+ I ++ + + +Q + Y A A + + + K L
Sbjct: 5353 -EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQL 5411
Query: 4242 GPIRLEQDQTTA----QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK 4297
I + + LQ K D+ + K E F S + + ++
Sbjct: 5412 ANISMSGNNLAEILPPALQDIKELQHDVQKTK----EAFLQNSSVLDRLPQPAESSTHML 5467
Query: 4298 TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDH 4357
+ + + L + + +++QF ++ +E + LI +
Sbjct: 5468 LPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF----KDFGVRLESLKGLIMH------EE 5517
Query: 4358 EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV--EEKYQKAENMYAQ 4415
E L + ++ ++ +S H + L P ++ LN ++ + + +NM Q
Sbjct: 5518 ENLDRLHQQEKENPDSFLNH---VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQ 5574
Query: 4416 IKEEVRQRALALDEAVS-QSTQITE-----------FHDKIEPMLE-----TLENLSSRL 4458
+R A AL+ Q + E +KIE L+ +L L +
Sbjct: 5575 W---IRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
Query: 4459 RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA--- 4515
+ ++ AEV I + I+D+ T L+ L + ++ R E + S+ D+ A
Sbjct: 5632 KTYKMLEAEVS-INQTIADSY-VTQSLQLLDTT--EIENRPEFITEFSKLTDRWQNAVQG 5687
Query: 4516 -KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK--------D 4566
++ + +D +V W+D F +E +F D + LL+ +K
Sbjct: 5688 VRQRKGDVDGLVRQWQD-----------FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
T+ ++H+L++ I +++ A T++ G L+ K
Sbjct: 5737 TRSLIHELKNKEIH--FQRRRTTCALTLEA---------------GEKLLLTTDLKTKES 5779
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---M 4683
V + I ++ ++W+++ E +++ + ++ Q + ++ + L V+K + +
Sbjct: 5780 VGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQ--VLKAQSEDPL 5837
Query: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
P + DL+ K+ + E+++ Q E++ + L + D +++E +
Sbjct: 5838 PELHEDLHNEKELIKELEQSLASWTQNLKELQTMKAD----LTRHVLVEDVMVLKEQIEH 5893
Query: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
L WE+L ++A R+ ++E L F +EL +WL E + IS + +
Sbjct: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMI- 5952
Query: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4863
E + ++ L + ++ + + G++L+++S A+ + +L +N W+ +
Sbjct: 5953 --EKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDV 6009
Query: 4864 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT-------GGLPETAREQL 4916
R ++L+ T Q + + L R+ES+LS KP + + EQ
Sbjct: 6010 IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQQ 6067
Query: 4917 DTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE-----QSVALLEQKWHVVS 4971
D ++ E +N + D +L D ++TE Q+ L+++W +
Sbjct: 6068 DLQRDIEQHSAGVESVFN-ICD-----VLLHDSDACANETECDSIQQTTRSLDRRWRNIC 6121
Query: 4972 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 5031
+ ER+ K+EE L +F + F +WL AE++ + ++ + +++ +
Sbjct: 6122 AMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEA 6181
Query: 5032 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD 5091
F +++ Q+ +++ +L ++ +K ++ RW+ + +R R L
Sbjct: 6182 FQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLR 6241
Query: 5092 DARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQP 5150
+ ++F + ++ WL + + L + S +D D QL+ FQ+ +
Sbjct: 6242 HFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLN---GFQQEITLNTN 6298
Query: 5151 VYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
D I G L +K+ P D+ +++ L E+ V G+ V R H+
Sbjct: 6299 KIDQLIVFGEQLIQKS-EPLDAVLIEDELEELHRYCQEVFGR-VSRFHR 6345
Score = 194 bits (493), Expect = 2e-48
Identities = 336/1735 (19%), Positives = 661/1735 (38%), Gaps = 199/1735 (11%)
Query: 3785 QDAL-EPLLSWLADTEELIANQKPPSAEYKV-VKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
QDAL + ++ + +E +A+ + KV ++AQI+ K+ + K DML +
Sbjct: 4740 QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ-----KLVADMLLIQ 4794
Query: 3843 GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ-------LEDILVLAKQFHE 3895
A SA++ + L++ E+ W E +++ +++ L+ +L ++F E
Sbjct: 4795 ----AYSAKI-----LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDE 4845
Query: 3896 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955
+ L + L + V ++ ++I ++ ++ +I ++Q + G+ L
Sbjct: 4846 NYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQL 4905
Query: 3956 -SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLA 4014
+S++ P +G +++ + + +I R ALL LS + D ++ WL
Sbjct: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS----YNRDSDQLTKWLE 4961
Query: 4015 EVEDKLS-----SVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL--KQ 4067
+ L+ S+ V D + + ++E+ + I G LL K+
Sbjct: 4962 SSQHTLNYWKEQSLNVSQ-DLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020
Query: 4068 TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE 4127
T + ++ L + ++ + L Q + + E+ W+ VE
Sbjct: 5021 T---DTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEH 5077
Query: 4128 ELATSGG-QSPTG-EQIPQFQQRQKELKKEVMEHRLVLDTVNE----VSRALLELVPWRA 4181
+ + SP+ Q+ Q+ KE + E+ + ++D VN+ +S +E +
Sbjct: 5078 QTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYER 5137
Query: 4182 REGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241
E + L + N Q+ V + +++ ++ ++ + E W+ + +L L
Sbjct: 5138 TEFAEHL-GEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL 5196
Query: 4242 GP---------IRLEQDQTTAQLQVQKAFSIDIIRHK----------------DSMDELF 4276
+ L+ QL + K+ ++D ++ +DELF
Sbjct: 5197 QKPESVISVQKLLLDCQDIENQLAI-KSKALDELKQSYLTLESGAVPLLEDTASRIDELF 5255
Query: 4277 SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 4336
RS + Q L+ +S++Q+++ L E ++ +FW E
Sbjct: 5256 QKRSSVL-----TQVNQLKTSMQSVLQEWKIYDQLYDE-------VNMMTIRFWYCMEHS 5303
Query: 4337 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP 4396
P + + E LR Q E ++ L++ + +KL ++ +LK L P
Sbjct: 5304 KPVV--------------LSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCP 5349
Query: 4397 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKI-------EPMLE 4449
E++EEK Q + Q+ + + + + + H + E +
Sbjct: 5350 SVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQ 5409
Query: 4450 TLENLS-SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508
L N+S S + ++P + I+E D +Q + EA + L Q
Sbjct: 5410 QLANISMSGNNLAEILPPALQDIKELQHD----------VQKTKEAFLQNSSVLDRLPQP 5459
Query: 4509 ADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
A+ + L + + + + +A E E + + + L+ ++
Sbjct: 5460 AESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRL-ESLKGLIMHEEE 5518
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
D +H E +P V A + + L+E +++ +D+
Sbjct: 5519 NLDRLHQQEKE--NPDSFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAV--------- 5565
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPP 4685
K++ MN W T ER +L Q + L W+ I+
Sbjct: 5566 --KTLQNMNRQWIRATATALERCSEL----QGIGLNEKFLYCCEKWIQLLEKIEEALKVD 5619
Query: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELK 4745
V L + +Q K + EV Q + Q +L E + I E ++L
Sbjct: 5620 VANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE-FSKLT 5678
Query: 4746 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEV 4805
W+N + + R+ ++G + F ++E L +LT T LL A + G +
Sbjct: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSA---VKGQERFSLY 5735
Query: 4806 ELAKH-HVLKNDVLAHQ---ATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861
+ H LKN + Q T +AG +LL ++ S+ R+ + W+ +
Sbjct: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDME 5795
Query: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921
+ E +Q QST++ +I++ L +++Q + P LPE E L E
Sbjct: 5796 PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ--SEDP---LPEL-HEDLHNEKE 5849
Query: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSKME 4975
L +L+ ++ Q L + + M + D E + L EQ +W + ++
Sbjct: 5850 LIKELEQSLASWTQNLKELQTM---KADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
Query: 4976 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE-----HK 5030
RK ++E+ LN F +E WL E +L T IEE K
Sbjct: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK---------VLQTADISIEEMIEKLQK 5957
Query: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
E+N + ++L Q G+QL S K I + L + RW+ + R + L
Sbjct: 5958 DCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
Query: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN-DPDKIKLQLSKHKEFQKTL---- 5145
+ +Q + L WL ES L + D +I+ +L++ ++ Q+ +
Sbjct: 6018 KETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS 6077
Query: 5146 GGKQPVY---DTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEE 5202
G + V+ D + A +T + + + +W +C S+ER+ K+EE
Sbjct: 6078 AGVESVFNICDVLLHDSDACANET----ECDSIQQTTRSLDRRWRNICAMSMERRMKIEE 6133
Query: 5203 ALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV 5262
+F+D DWL E A + + FQ+++ +R +
Sbjct: 6134 TWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQL 6193
Query: 5263 QVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 5321
+++ + R L +R DT + +K + E + RWD + + + RL Q E F T
Sbjct: 6194 ELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGT 6253
Query: 5322 VHMLLEWLSEAEQTL----RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMG 5377
+L WL+E + L F + DD ++ L F +++ ++ + G
Sbjct: 6254 RESILVWLTEMDLQLTNVEHFSESDADD--KMRQL----NGFQQEITLNTNKIDQLIVFG 6307
Query: 5378 EVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLE 5432
E ++ P I+ + + +EV + +RL + L E E
Sbjct: 6308 EQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASE 6362
Score = 188 bits (478), Expect = 1e-46
Identities = 631/3394 (18%), Positives = 1314/3394 (38%), Gaps = 522/3394 (15%)
Query: 1781 KGNGGVNPEPFRATQNVFTRQLCLEHDEK-----LVSYLSLLRNIEMRTKQIQPLELNLA 1835
K N N + ++ QN+ E DEK L + L +L I+ + +Q + L +
Sbjct: 3124 KLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIK 3183
Query: 1836 ELQDLLCQAKVLERE-------LKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA 1888
+Q+ + + + +K +T + Q E S+ +V +L ++
Sbjct: 3184 HIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENS-----SEASDVETKL-----REF 3233
Query: 1889 KNLQKSLSSVSDTWNSRLLH-FQNAVEIEK--TKVLNQHTQLEGRLQDLRAWVGNKNLIL 1945
++LQ L++ D + L ++N ++ T+ + T LE + R VGN
Sbjct: 3234 EDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPE--- 3290
Query: 1946 NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQ 2005
+SL + L++ E+L+ +A IQ + SP+ Q
Sbjct: 3291 -----------ESLEMPLRKQEELESTVAH-----------IQDLTEKLGMISSPEAKLQ 3328
Query: 2006 MLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV---KTLQKQQNTCHQQLEDLC 2062
LQ + Q+++ + +A +A + Q+ E E + K +K + + L +
Sbjct: 3329 -------LQYTLQELVSKNSAMKEAFKA--QETEAERYLENYKCYRKMEEDIYTNLSKME 3379
Query: 2063 SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 2122
+ +GQ+ +L + ++ L L+++++ + +L + +++ + EN
Sbjct: 3380 TVLGQSMSSLP----LSYREALERLEQSKALVSNLIST-KEELMKLRQILRLLRLRCTEN 3434
Query: 2123 QTKLSPRELTALREK----LHQAKEQY---EALQEETRVAQKELEEA--VTSALQQETEK 2173
+ ++AL EK L AKE E L++E + +E+E + LQ+E +
Sbjct: 3435 DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPE 3494
Query: 2174 SKAAKELAENKKKIDALLDWVTSVGSS--GGQLLTNL--PGMEQLSGASLEKGALDTTDG 2229
KE A ++ + LLD + G + QLL L + + GA++T
Sbjct: 3495 ISKTKEAATTEE-LSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPA 3553
Query: 2230 YMGV-------NQAPEKLDKQCEMMKA----RH---QELLSQQQNFILATQSAQ--AFLD 2273
+ + N+ +K+ K E+++ RH +E+++ + F T S Q AF D
Sbjct: 3554 FQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQD 3613
Query: 2274 QHGHNLTPEEQQMLQQKLGEL-------------KEQYSTSLAQSEAELKQVQTLQDELQ 2320
+ EE Q + +K G+L E Y+ A+ E+++++ + +++
Sbjct: 3614 HPEKSEQFEELQSILKK-GKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672
Query: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTIS 2380
+ + + S +++E ++ G + E + + ++++ D + S
Sbjct: 3673 EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHS 3732
Query: 2381 GQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQ 2440
LD E ++P + + D L ++Y + + S LN + ++
Sbjct: 3733 KLNELDSEVQDIVEQDPGQAQEWM-DNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYS 3791
Query: 2441 NSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVA 2500
+ S +AW++ N LL++ D A+T Q+ E +E + + L +
Sbjct: 3792 DLLKSTEAWIE----NTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL--LHSIF 3845
Query: 2501 RDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
D+ ++ + TD + Q LS + + +++ Q Q + + + ++
Sbjct: 3846 MDLEDLS---------IIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIE 3896
Query: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEAT-REMVTRFMETAD 2619
+ +E+ + + LS + + ++K + I ++ T E+V+ +E
Sbjct: 3897 SEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRL 3956
Query: 2620 STTAAVLQGKLAEVSQRFEQLCLQQ---QEKESSLKKLLPQAEMFEHLSGKLQQFMENKS 2676
T +Q + + L + QE+ LK ++ Q ++ L+Q + N S
Sbjct: 3957 PQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Query: 2677 RMLASGNQ-PDQDITHFFQQIQELNLEMEDQQENLDTL----EHLVTELSSCGFALDLCQ 2731
+ + PDQ ++ +L E+E ++ + +L E L+ +L + L+L Q
Sbjct: 4017 AQFSLEHMSPDQA-----DKLPQLQGEIERMEKQILSLNQRKEDLLVDLKAT--VLNLHQ 4069
Query: 2732 HQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS 2791
H + Q + E + ++ + E + R +L E + E+S
Sbjct: 4070 HLKQEQ----EGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVE--ESS 4123
Query: 2792 MSAKELEKQIE-----------HLKSLLDDWASK--GTLVEEINCKGTSLENLIMEITAP 2838
+ + +++ E H K + +D AS GT+V+E K ++ +N + +I P
Sbjct: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
Query: 2839 DS--------------QGKTGSILPSVGSSVGSVNG------------------YHTCK- 2865
DS Q + G+ P ++ S + H CK
Sbjct: 4184 DSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKT 4243
Query: 2866 DLTEIQCDMSDVNLKYE------KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919
+ E++ + N+ E + VL ++ QA+L +E HK A +L+ + +
Sbjct: 4244 QVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIE--HKVA-FLLETCKDQ 4300
Query: 2920 ---EEVLKSMDAMSSPTKTETVKAQAESNKAFLAE--LEQNSPKIQKVKEALAGLLVTYP 2974
+ +A + K +TVK E + L E E P I K + P
Sbjct: 4301 GLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKS--------SEP 4352
Query: 2975 NSQEA---ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEK 3031
QEA N +++ + R + + + +Q+ LE L+P + +K
Sbjct: 4353 EHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLE---------------LKP-MEQK 4396
Query: 3032 ELMMGVLGPLSIDPNMLNAQKQQVQF------MLKEFEARRQQHEQLNEAAQGILTGPGD 3085
+ + + NA+K Q+ +E A Q N+ IL+ G
Sbjct: 4397 DFIKFI---------EFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQ 4447
Query: 3086 ---------------VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 3130
+ L Q+ + S N + N R ++ +TQ ++
Sbjct: 4448 NGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLED 4507
Query: 3131 LLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL 3190
L Q+ S ++Q+ + EA ++ E+ L Q V+E E+
Sbjct: 4508 LRQEAS----------NLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEML----EM 4553
Query: 3191 SVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA----STQQFQQMFDELR 3246
L E ++ ET+AL L+ L +D+ L A+ +T + FD L+
Sbjct: 4554 PRLYREDGSGQQV--HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQ 4611
Query: 3247 TWLDDKQ------SQQAK-----NCPISAKLERLQSQL-QENEEFQKSLNQHSG------ 3288
L+ Q S+ K N +++RL QL + Q+SLN+ SG
Sbjct: 4612 VCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQ 4671
Query: 3289 -----SYEVIVAEGESLLLSVPPGEEK----RTLQNQLVELKNHWEELSKKTADRQSRLK 3339
+Y V + ES + + E+ L ++ +L++ + + R + L
Sbjct: 4672 LQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS 4731
Query: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRS 3397
+ ++ +V ++ K K++ L+ T V L++ + K ++
Sbjct: 4732 SPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLV--AD 4789
Query: 3398 LLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG-SLEEMTQRLREFQ 3456
+L I +A IL + + E ++ + + EE + G L+ + Q+ EF
Sbjct: 4790 MLLIQAYSAKILPSLLQNRETFWAEQVTEVK-----ILEEKSRQCGMKLQSLLQKWEEFD 4844
Query: 3457 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3516
E++ ++EK +E + L S + + E+L + Q ++ +
Sbjct: 4845 ENYASLEKDLE------ILISTLPSVSLVEETEERLVERISFYQQIKRNI---------- 4888
Query: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNS-GCVMMENKLEGI-GQFHCRVREMFSQ 3574
G ++L Q E KQ V S C +E ++ + Q+ +++ +
Sbjct: 4889 ------GGKHARL-------YQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE 4935
Query: 3575 LADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKL----DIEASEAECRHMLEEE 3630
L L L + + RD+D L +E + LN L D++ + + E
Sbjct: 4936 LHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFS 4995
Query: 3631 GTLD-LLGLKRELEALNKQCGKLTERGKAR--------QEQLELTLGRVEDFYRKLKGLN 3681
+D LK + ++ Q L E A +++ + + ++ D KL L
Sbjct: 4996 KEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
Query: 3682 DATTAAEEA--EALQWVVGTEVEIINQQLADF--------KMFQKEQVDPLQMKLQQ--V 3729
+ +A E + W+ E + ++ + QK + ++M +Q V
Sbjct: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
Query: 3730 NGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
+ + Q L+Q + CDV+ ++ + E+N +W+ ++ + ++I L++ L
Sbjct: 5116 DFVNQSLLQLS--TCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESIT 5173
Query: 3783 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQA- 3841
+ ++ ++ L +WL EE + + P + V K + Q + +L KA ++ Q+
Sbjct: 5174 ESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSY 5233
Query: 3842 ---EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE 3898
E G + + A R ++ L + + +L++ + ++ +L K + + +
Sbjct: 5234 LTLESGAVPLLEDTASR------IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYD 5287
Query: 3899 PISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL 3958
++ + +S+PV ++ Q+ ++L+++ E+ + ++ L L
Sbjct: 5288 EVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL 5347
Query: 3959 TSPAEQGVLSEKIDSLQARYSE----IQDRCCRKAALLD--QALSNARLFGEDEVEVLNW 4012
P+ ++ EK + R+++ I D+ + +LL +A SNA GE +
Sbjct: 5348 -CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH--GEAAARLKQQ 5404
Query: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
A+ + + + ++L D L ++ K+ Q L +
Sbjct: 5405 EAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESST 5464
Query: 4073 VLLIQEKLDGI-KTRYAD--ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL 4129
+L+ L + + Y + + V +++ L Q + + +S L G + EE L
Sbjct: 5465 HMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLES----LKGLIMHEEENL 5520
Query: 4130 ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL-------DTVNEVSRALLELVPWRAR 4182
+ Q++KE + H L L + +NEVS L
Sbjct: 5521 -------------DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKL------PLS 5561
Query: 4183 EGLDKLVSDANEQYKLVSDTIGQRVDEIDAA-------------IQRSQQYEQAADAELA 4229
+ K + + N Q+ + T +R E+ IQ ++ E+A ++A
Sbjct: 5562 DVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVA 5621
Query: 4230 WVAE---TKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTC 4286
++K + + +QT A V ++ + ++ E + S++
Sbjct: 5622 NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRW 5681
Query: 4287 GEEQKTVLQEK--TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETR 4344
+ V Q K + L++Q++ + + L L++ + E S + +TR
Sbjct: 5682 QNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAV-KGQERFS--LYQTR 5738
Query: 4345 ALIAQLPSPAIDHEQLRQ------QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398
+LI +L + I ++ R + E L + + ++ ++ K++ P+
Sbjct: 5739 SLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQL 5798
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ-ITEFHDKIEPMLETLENLSSR 4457
EM+++ +Q + Q ++++++ L +QS + E H+ + E ++ L
Sbjct: 5799 AEMIKQ-FQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQS 5857
Query: 4458 L-----RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512
L + L + D R + + ++ L+ E L R+ E+L R
Sbjct: 5858 LASWTQNLKELQTMKADLTRHVLVE------DVMVLKEQIEHLHRQWEDLCLRVA----- 5906
Query: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
+ +EI+D+L+ V F E K EL W + + + T DI
Sbjct: 5907 IRKQEIEDRLNTWVVFNEKNK--------------ELCA--W--LVQMENKVLQTADI-- 5946
Query: 4573 DLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSID 4632
I+ I K Q + EE + E ++ +G LI A ++ E+ ++
Sbjct: 5947 -----SIEEMIEKLQKDC----MEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLN 5997
Query: 4633 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL-- 4690
++N+ W++L R++KL++ Q + + WL +L PV D+
Sbjct: 5998 KINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVVYDVCD 6055
Query: 4691 -NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA---TDETDRDIIREPLTELKH 4746
++ +L E ++ + ++ Q +E + + +++L + +ET+ D I++ L
Sbjct: 6056 DQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDR 6115
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W N+ R+ K+E +F WL E + E
Sbjct: 6116 RWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE 6175
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
L + + + +E +NK L + D AS L+ + NQ W+++ ++
Sbjct: 6176 LKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTA 6235
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS 4900
++L+ Q + F E L+ LT M+ QL+
Sbjct: 6236 VLRRLRHFTNQREEFEGTRESILVWLTEMDLQLT 6269
Score = 172 bits (435), Expect = 1e-41
Identities = 668/3541 (18%), Positives = 1348/3541 (38%), Gaps = 525/3541 (14%)
Query: 1804 LEHDEKLV----SYLSL-----LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELK-- 1852
L H EKL+ YL L IE++ KQ L LQ+ Q K+ ++ LK
Sbjct: 2134 LSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHG-LQEKKAQLKIYKKFLKKA 2192
Query: 1853 -DLTTLVSQE-------LECVNQIIISQP-----QEVPAQLLKALEKDAKNLQ------- 1892
DLT+L+ + LEC S+ + + LL+ L+ +NL
Sbjct: 2193 QDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHD 2252
Query: 1893 ------KSLSSVSDTWNSRLLHF------QNAVE--IEKTKVLNQHTQLE-GRLQDLRAW 1937
L++ D ++ + F Q AVE ++K + L L+ G L+ + A
Sbjct: 2253 SYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILAL 2312
Query: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997
K++ N+ +I D + + +DL+ +A K +++ I +
Sbjct: 2313 A--KSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI-------LKS 2363
Query: 1998 LSPQQNRQMLRLLNELQRSFQDILEQT--AAQVDALQGHLQQMEQEALVKTLQKQQNTCH 2055
+ + L +++ D+ E T +A V+ L+ + + A+ + KQ +
Sbjct: 2364 KRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNA 2423
Query: 2056 QQ----------LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDL-QDDIQNR 2104
Q+ + +L + + + L Q ++ + L+ ++ +K L Q + N+
Sbjct: 2424 QESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNK 2483
Query: 2105 ATSFATVVKDIEGFMEENQTKLSPRELTALREK------LHQAKEQYEALQEETRVAQKE 2158
+ A V+ +I G+ ++ L +T + K L +E A++ + +
Sbjct: 2484 TETGALVLHNI-GYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTD 2542
Query: 2159 LEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGAS 2218
E L T K K +A +K+ D+L ++ L ++ M++
Sbjct: 2543 KESLKVGPLDSVTYLDKIKKFIASIEKEKDSL----GNLKIKWENLSNHVTDMDK---KL 2595
Query: 2219 LEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHN 2278
LE G+ V Q +K Q + L+++ Q+ ++ Q Q L +
Sbjct: 2596 LESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKS 2655
Query: 2279 LTPEEQQ------MLQQKLGELKEQYSTSLAQSEAELKQV------QTLQDELQKFLQDH 2326
PEE+ L L K +S Q+E ++K++ + L+D + +
Sbjct: 2656 --PEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQW 2713
Query: 2327 KEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS-------EDVISHKGDLRFVTI 2379
+ E +E +++ ET+ G + +D++S +R +
Sbjct: 2714 ETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQ---IRKCKV 2770
Query: 2380 SGQKVLDMENSFK------EGKEPSEI---GNLVKDKLKDATERYTALHSKCTRLGSHLN 2430
+ +L + S + + K PS G+ + + L+D +Y L K T+ L
Sbjct: 2771 THDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
Query: 2431 MLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ 2490
L + F Q +Q E + + + + A T + EL H
Sbjct: 2831 FKLEERSNFFAIIRKFQLMVQESETLI-------------IPRVETAAT---EAELKHHH 2874
Query: 2491 VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSI--LSHFQSLSY-----SLAERSSLLQ 2543
V +E QK ++ EI+ + H+QE T+ L+ F+ L +L R++ +Q
Sbjct: 2875 VTLEASQK---ELQEIDSGIST---HLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQ 2928
Query: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603
+ I + + E + E L+ ++ S+ + N +K++I K
Sbjct: 2929 RFIQNTCNEVEHKIKFCRQFHEKTSALQ-EEADSIQRNELLLNQEVNKGVKEEIYNLKDR 2987
Query: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663
L A + + + ++ L +++ +QL Q EKE L++ + Q + FE
Sbjct: 2988 LTAIKCCILQVLKLKKVFDYIGLNWDFSQL----DQLQTQVFEKEKELEEKIKQLDTFEE 3043
Query: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV----TE 2719
GK Q + S+M A Q +++ E+ L+ D L + E
Sbjct: 3044 EHGKYQALL---SKMRAIDLQ--------IKKMTEVVLKAPDSSPESRRLNAQILSQRIE 3092
Query: 2720 LSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLK 2779
+ C LC + N K F + K EK+ + +E KL + Q +
Sbjct: 3093 KAKC-----LCDEIIKKLNENKTFDDSFK-----EKEILQIKLNAEENDKLYKVLQNMVL 3142
Query: 2780 ETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD 2839
E + P E + K + ++E +L+ S+ IN + ++N
Sbjct: 3143 E----LSPKE--LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQN--------- 3187
Query: 2840 SQGKTGSILPSVGSSVGSVNGYHTC-KDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898
+ + V + + S+ K E + SDV K + + + S+
Sbjct: 3188 EKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLR 3247
Query: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE--TVKAQAESNKAFLAELEQNS 2956
N + + ++ + + E + S++A+ P + + + E ELE
Sbjct: 3248 TNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTV 3307
Query: 2957 PKIQKVKEALAGLLVTYPNSQEAE-NWKKIQEELNSRWERATEVTVARQRQLEESASHLA 3015
IQ + E L + +S EA+ + +EL S+ E A++ + E +
Sbjct: 3308 AHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYK 3362
Query: 3016 CFQAAESQLRPWLMEKELMMG-VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
C++ E + L + E ++G + L + + +Q + ++ + +++ +L +
Sbjct: 3363 CYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQ 3422
Query: 3075 AAQGI---LTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL 3131
+ + T + L K + ++ +KW+ L + + +++
Sbjct: 3423 ILRLLRLRCTENDGICL-----LKIVSALWEKWLSLLE--------------AAKEWEMW 3463
Query: 3132 LQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELS 3191
++L ++ + V + + ++ I + ++++L E S + KEA T +ELS
Sbjct: 3464 CEELKQEWKFVSEEIEREAIIL---DNLQEELPEIS-----------KTKEAAT-TEELS 3508
Query: 3192 VLIG--EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL 3249
L+ QY ++ K++L + L LQ + + + A+ + FQ++ T +
Sbjct: 3509 ELLDCLCQYGENVEKQQL-LLTLLLQRIRSI--QNVPESSGAVETVPAFQEI-----TSM 3560
Query: 3250 DDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE 3309
++ ++ + + E +Q+++QE F K ++++ +
Sbjct: 3561 KERCNKLLQK--VQKNKELVQTEIQERHSFTKE------------------IIALKNFFQ 3600
Query: 3310 KRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSEL 3369
+ T Q + ++H E S++ + QS LK K + E++ +E + K SE+
Sbjct: 3601 QTTTSFQNMAFQDH-PEKSEQFEELQSILK-------KGKLTFENI---MEKLRIKYSEM 3649
Query: 3370 RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQ 3429
T+ P ++ES + + L +++++ S + +S + + E +G+ + + + Q
Sbjct: 3650 -YTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ 3708
Query: 3430 NMDAV--TEELQAKT-GSLEEMTQRLREFQESFKNIEKKVEGAKHQ--------LEIFDA 3478
+ +E+Q K L+ +L E ++I ++ G + + +
Sbjct: 3709 KSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQ 3768
Query: 3479 LGSQA-CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537
+ +A C L K + E L + T L+ + D L H A Q
Sbjct: 3769 VSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQ 3828
Query: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
LE Q H + +F L DL +I +TD L
Sbjct: 3829 M------------------ALEDSEQKHNLLHSIFMDLEDL--------SIIFETDELTQ 3862
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK 3657
I+++ N++ L+ I S + + M + D++ ++ E++++ K+ K+
Sbjct: 3863 SIQELS---NQVTALQQKIMESLPQIQRMAD-----DVVAIESEVKSMEKRVSKIKTILL 3914
Query: 3658 AR-------QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG--TEVEIINQQL 3708
++ +E L+ +E+ K + + + E Q + + NQ L
Sbjct: 3915 SKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLL 3974
Query: 3709 ADFKMFQ---KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNT--L 3763
D K+ + +EQ + L++ ++Q N D +++ L+ + +A+++ +
Sbjct: 3975 QDIKLLENVTQEQNELLKVVIKQTNEW----------DEEIENLKQILNNYSAQFSLEHM 4024
Query: 3764 NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQK 3823
+ A ++ QLQ G+ + + +LS E+L+ + K + + + QEQ+
Sbjct: 4025 SPDQADKLPQLQ------GEIERMEKQILSLNQRKEDLLVDLK--ATVLNLHQHLKQEQE 4076
Query: 3824 LLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3883
++R DR V EGG +A+R+ +L S +S AA ++++
Sbjct: 4077 GVER---DRLPAV--TSEEGG-------VAERDASERKLNRRGS-----MSYLAAVEEEV 4119
Query: 3884 EDILVLAKQFHETAEPISDFLSVTEK--KLANSEPVGTQTAKIQQQII---------RHK 3932
E+ V + E AEP S K K + + + I Q+ +
Sbjct: 4120 EESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQ 4179
Query: 3933 ALEEDIENHATDVHQAVKIGQSLSSLTSPAE---------QGVLSEKIDSLQARYSEIQD 3983
L D N +++ Q+ T P E QG L +++ + +E+
Sbjct: 4180 ILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLH 4239
Query: 3984 RCCRKAALLDQALSNARLFGEDEV------EVLN--------WLAEVEDKLSSVFVKDFK 4029
C + A L+ L A + E E +VL L E+E K++ +
Sbjct: 4240 ACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKD 4299
Query: 4030 QDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYAD 4089
Q + H A E + + K V ++ Q +L++ E+ K
Sbjct: 4300 QGLGDNGATQHEA--EALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEA 4357
Query: 4090 ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQ 4149
+ + L ++ R ++ + ++ L+ +E++ + + PQ+ Q
Sbjct: 4358 LQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHD 4417
Query: 4150 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209
+ +E N+V ++L + + G DK +E + + Q V+
Sbjct: 4418 NDTTQESSASNQASSPENDVPDSILSP---QGQNG-DKWQYLHHELSSKIKLPLPQLVEP 4473
Query: 4210 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHK 4269
+ + E K L +R Q + LQ Q+ + + +
Sbjct: 4474 QVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLR----QEASNLQTQENMTEEAYINL 4529
Query: 4270 D-SMDELFSHRSEIFGTCGE--EQKTVLQEKTESLIQQYEAISLLNSERYARL--ERAQV 4324
D + ELF S+ + E E + +E YE ++L + Y L ++ +
Sbjct: 4530 DKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDL 4589
Query: 4325 LVNQFW---------ETYEELSPWIEETR-ALIAQLPSPAIDHEQLRQQQEEMRQLRESI 4374
L W E ++ L +E T+ A + + S + R Q E+++L +
Sbjct: 4590 LKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL 4649
Query: 4375 AEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEA---- 4430
+ K + + LN G+ V E+ QKA+ +++ + A DE
Sbjct: 4650 IKSKTSLQ---------QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLH 4700
Query: 4431 --VSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE------CISDNKSAT 4482
+ ++ + D ++ M L + L P + ++ D + + I K A
Sbjct: 4701 LPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAH 4760
Query: 4483 VELEK------LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED----- 4531
L++ LQ E K ++L+ + +AK + L FW +
Sbjct: 4761 GHLKQTKSKVALQAQIENHKVFFQKLVA-DMLLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
Query: 4532 --IKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVE 4589
++ ++ + +K +L+ E+F + A+L KD + ++ L S + ++ VE
Sbjct: 4820 KILEEKSRQCGMKLQSLLQKWEEFDENYASL---EKDLEILISTLPSVSLVEETEERLVE 4876
Query: 4590 AA---ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWK 4646
+ IK G H L G L+ PE+ I ++ W +LNK
Sbjct: 4877 RISFYQQIKRNIGGKHARLYQTLNEGKQLV---ASVSCPELEGQIAKLEEQWLSLNKKID 4933
Query: 4647 ERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP----VGTDLNTVKDQLNEMKE 4702
L +L+ ++ + Y + WL+++ L V DL+T++ +N E
Sbjct: 4934 HELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFE 4993
Query: 4703 FKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKL 4762
F EV ++ + G +L ETD +R L + + W L ++ Q KL
Sbjct: 4994 FSKEVDEKSSLKTAVISIGNQLLH--LKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
Query: 4763 EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--LAKHHVLKNDVLAH 4820
+ + A+ E++SW+ + E + + +V+ L KH + ++
Sbjct: 5052 HQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYK 5111
Query: 4821 QATVETVNKAGNELLESSAGDDASSLRSRLE------AMNQCWESVLQKTEEREQQLQST 4874
Q V+ VN++ LL+ S D S R E MN+ W V + Q L+
Sbjct: 5112 QWIVDFVNQS---LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQL 5168
Query: 4875 LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYN 4934
L+ ++I+ L E +L + + + LD ++ +QL K + +
Sbjct: 5169 LESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDC-QDIENQLAIKSKALD 5227
Query: 4935 QLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4994
+L K + L +SG +V LLE + ++R S L + L T Q+
Sbjct: 5228 EL--KQSYLTL---ESG-------AVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSV 5275
Query: 4995 LQEF---------INWLTLA-EQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044
LQE+ +N +T+ + + P L L T+ Q+E + +E +
Sbjct: 5276 LQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWE 5335
Query: 5045 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAW 5104
+L + +LK L +I+ + RW +V Q ++ D ++A+ + W
Sbjct: 5336 KLQEVIGKLKGLCPSV-AEIIEEKCQNTHKRWTQVNQ-------AIADQLQKAQSLLQLW 5387
Query: 5105 K 5105
K
Sbjct: 5388 K 5388
Score = 122 bits (305), Expect = 1e-26
Identities = 555/3237 (17%), Positives = 1235/3237 (38%), Gaps = 420/3237 (12%)
Query: 2447 QAWMQACEANVEKLLSDTVASDPGV--LQEQLATTKQLQEELAEHQ-------------- 2490
+AW+Q E +++ LS + V +QE++ K L + H
Sbjct: 396 EAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHL 455
Query: 2491 --VPVEKLQKVARDIMEIEGEP----APDHRH---VQETTDSILSHFQ--SLSYSLAERS 2539
VP KL+++ R I I + H + V D + S ++ Y E
Sbjct: 456 PLVPPNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV 515
Query: 2540 SLLQK---AIAQSQSVQESLESLLQSIGEVEQNLEG------KQVSSLSSGVIQEALATN 2590
LL + + + L++ Q GE+ +NL G KQ + S V
Sbjct: 516 ELLLEDWHKFIEEKEFLARLDTSFQKCGEIYKNLAGECQNINKQYMMVKSDVCM------ 569
Query: 2591 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2650
+++I KS+L+ ++E A + K E+ + + Q + ++
Sbjct: 570 --YRKNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHAT 627
Query: 2651 LKKL------LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEME 2704
L + + + +S +L++ + + R L S Q + ++ I++ +
Sbjct: 628 LNEAGNFLVEVSNDVVGSSISKELRR-LNKRWRKLVSKTQLEMNLP---LMIKKQDQPTF 683
Query: 2705 DQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQL 2764
D N+ + E T S +++L ++ + QN++ +K KE E+ +
Sbjct: 684 DNSGNILSKEEKATVEFSTDMSVELPENYN--QNIKAG----EKHEKENEEFTGQLKVAK 737
Query: 2765 DEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCK 2824
D KL+ + W E + + + S +E K + S+ D+ ++ + +++ +
Sbjct: 738 D-VEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQ 796
Query: 2825 GTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKL 2884
S + + Q K V +V V K+LT++ D+ D+ LK E+
Sbjct: 797 NISSQESFQHVLTTGLQAKIQEAKEKVQINV--VKLIAALKNLTDVSPDL-DIRLKMEES 853
Query: 2885 GGVLHERQESLQAILNRMEEV------HKEANSVLQWLESKEEVLKSMDAMSSPTKTETV 2938
L Q +L + E HKEA ++ +S + LK+++ + + +
Sbjct: 854 QKELESYMMRAQQLLGQRESPGELISKHKEA-LIISNTKSLAKYLKAVEELKNNVTEDIK 912
Query: 2939 KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE 2998
+ E ++ A+ E ++ + L + + ++N K+++++N +
Sbjct: 913 MSLEEKSRDVCAKWESLHHELSLYVQQLK---IDIEKGKLSDNILKLEKQINKE-----K 964
Query: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 3058
+ R R H ACF L + M VL L + +Q Q+V+ +
Sbjct: 965 KLIRRGRTKGLIKEHEACFSEEGC-----LYQLNHHMEVLRELCEELPSQKSQ-QEVKRL 1018
Query: 3059 LKEFEARRQQ--------HEQLNEAAQGILTGPGDVSLSTSQ----------VQKELQSI 3100
LK++E + ++ H L A G G ++ S ++ + + Q
Sbjct: 1019 LKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
Query: 3101 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ-DLSEKVRAVGQRLSVQSAISTQPEAV 3159
+K +E T K + S +++ Q + +++ D S + ++ +R I +
Sbjct: 1079 TEKAMEPTMKFSLAS------VLRPLQEESIMEKDYSASINSLLERYDTYRDI-LEHHLQ 1131
Query: 3160 KQQLEETSEIRSDLEQ----LDHEVKEAQTLCDELSVLIGE-QYLKDELKKRLETVALPL 3214
+ TS+ S+ ++ L ++ + Q + +E E + + +L+ + + P
Sbjct: 1132 NNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPF 1191
Query: 3215 QGLE-DLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ- 3272
E D +R LQ L + + + + LR L +++ C L ++ Q
Sbjct: 1192 VIKERDTLKERERELQMTLNT--RMESLETALRLVLPVEKASLLL-CGSDLPLHKMAIQG 1248
Query: 3273 ---------LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNH 3323
Q Q S+ + + G +L + P + +QN +++ K
Sbjct: 1249 FHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFD-LHAMQNIILKYKTQ 1307
Query: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
+E ++ + +Q++ ED + +ED A + +++ +PV S+
Sbjct: 1308 FEGMNHR-----------VQRS-------EDTLKALEDFLASLRTAKLSAEPVTDLSASD 1349
Query: 3384 RSKAMLNE--VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 3441
A N V+ + + ++ A L + + +D + G + + + + + K
Sbjct: 1350 TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK 1409
Query: 3442 T------GSLEEMTQRLREFQES-FKNIE--KKVEGAKHQLEIFDALGSQACSNKNLEK- 3491
G EE T+ + + FKN E K ++ + Q+ + K+ +K
Sbjct: 1410 LSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
Query: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551
L +VL E + +L+ L DG + + + Q + + K V
Sbjct: 1470 LIRLDKVLDEYEEEKRHLQEMANSLPH-FKDGREKT-VNQQCQNTVVLWENTKALVTECL 1527
Query: 3552 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3611
LE + Q+ + + + L ++ + + A ++L+ +I ++ + + +
Sbjct: 1528 EQCGRVLELLKQYQ-NFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE 1586
Query: 3612 LKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3668
++ C+++ L + T + ++E + + + E+ + E L L
Sbjct: 1587 HLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALA 1646
Query: 3669 RVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3728
+ + +++ T A + L + + E + ++L +++ ++ +
Sbjct: 1647 LWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL----QVHEQKTSEFSRRVAE 1702
Query: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC-----GK 3783
+ Q L+QS+ ++Q +E + LNK + E+ H +
Sbjct: 1703 I----QFLLQSSEIPLELQVMESSI---------LNKMEHVQKCLTGESNCHALSGSTAE 1749
Query: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
++ L+ + + TE L+ P + K + +Q++LQ+ K ++ +L+ +
Sbjct: 1750 LREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQ-----KHSMILLENQI 1804
Query: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
G + T +L L+ ++ + ++ L+D +K ++ + +D+
Sbjct: 1805 GCL------------TPELSELKKQYESVSDLFNTKKSVLQDHF--SKLLNDQCKNFNDW 1850
Query: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3963
S + L ++T K +Q ++ + +E + + Q + + + A
Sbjct: 1851 FSNIKVNLKECFE-SSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAH 1909
Query: 3964 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 4023
L + + +++ C +A L+ +L +D + WL E+K +
Sbjct: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
Query: 4024 FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083
K ++ LA E ++ ++K ++ E + ++ +
Sbjct: 1970 EEPGEKTELF----CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTL 2025
Query: 4084 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGE 4140
+ ++I K L T +Q+ F ++ W++E++E L +S G+ P E
Sbjct: 2026 LRQLSEIE-EEDKLLPTEDQS------FNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
Query: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVN---EVSRALLELVPWRAREGLDKLVSDANEQYK 4197
+I Q+ KE+ E ++T+ E S A L + K ++D + Q+
Sbjct: 2079 RI----QKIKEIILLKPEGDARIETIMKQAESSEAPL----------VQKTLTDISNQWD 2124
Query: 4198 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQV 4257
+ + + ++Y Q+ + + E K+K A ++ + AQL++
Sbjct: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKI 2184
Query: 4258 QKAFSIDIIRHKDSMDELFSHRSEIFG-----TCGEEQKTVLQEKTESLIQQYEAISLLN 4312
K F + EL S + + + EE ++ ESL+QQ + S+ N
Sbjct: 2185 YKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD-SVQN 2243
Query: 4313 SERYARLERA-QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 4371
+ + R + QV V T + S + ++ P +D + ++ +++++L
Sbjct: 2244 LDGHVREHDSYQVCVTDLNTTLDNFS------KEFVSFSDKP-VDQIAVEEKLQKLQELE 2296
Query: 4372 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE--------KYQKAENMYAQIKEEVRQR 4423
++ + K+L + +K+ G+ + + K + EN A K+E+
Sbjct: 2297 NRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEME-- 2354
Query: 4424 ALALDEAVSQSTQITEFHDKIE-PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSAT 4482
++ +S + TE K P E + +S ++ A V+K+ E NK +
Sbjct: 2355 --CCLNSILKSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
Query: 4483 VELEKLQP----SFEALKRRGEEL-IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4537
VE+ + + E++K +E + Q +L ++L+++ + ++A+
Sbjct: 2411 VEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK-- 2468
Query: 4538 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-------PGIDPSIIKQQVEA 4590
+ IK L+ E K L Q + + L++ +++ E
Sbjct: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
Query: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEK--PEVRKSIDEMNNA---WENLNKTW 4645
++ L + E +++ D + + +K + K D + N WENL+
Sbjct: 2529 LAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHV 2588
Query: 4646 KERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV 4705
+ +KL ++ +++ ++ ++ + K + V D T +N++++ ++
Sbjct: 2589 TDMDKKLLESQIKQLEHG------WEQVEQQIQKKYSQQVVEYDEFTTL--MNKVQDTEI 2640
Query: 4706 EVYQQQIEMEK------------------------------LNHQGELMLKKATDETDRD 4735
+ QQQ ++ L Q EL +K+ E ++
Sbjct: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
Query: 4736 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4795
+ + + LK WE L +++++ ++ ++E + W + L+ P
Sbjct: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKC-----DIRNKMKETILWAKNLLGELNPSIP 2755
Query: 4796 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855
+ D + ++ K V + +LA Q +VE++ + + + S + S L + LE +
Sbjct: 2756 LLPDDILSQIRKCK--VTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRN 2813
Query: 4856 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQ 4915
++ ++ K+ +R QQL+ L++ F + I F L + E+ + T T E
Sbjct: 2814 QYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAA---TEAEL 2870
Query: 4916 LDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975
H+ L + K +E DSG + ++ + E+ +E
Sbjct: 2871 KHHHVTLEASQKELQEI----------------DSGISTHLQELTNIYEELNVFERLFLE 2914
Query: 4976 ERKSKLEEALNLATEF-QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
++ L+ N F QN+ E + + Q S L I+ +++ N
Sbjct: 2915 DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSA----LQEEADSIQRNELLLN 2970
Query: 5035 -EVNAH-RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE-----KVVQRSIERG 5087
EVN +++I L +K + V+ +K + + W+ ++ + E+
Sbjct: 2971 QEVNKGVKEEIYNLKDRLTAIKCCILQ--VLKLKKVFDYIGLNWDFSQLDQLQTQVFEKE 3028
Query: 5088 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGG 5147
+ L++ K+ F E K L + I LQ+ K E
Sbjct: 3029 KELEEKIKQLDTFEEEHGKYQALLSKMRA--------------IDLQIKKMTEVVLKAPD 3074
Query: 5148 KQPV---YDTTIRTGRALKEKTLLPEDSQKLDN---FLGEVRDKWDTVCGKSVERQHKLE 5201
P + I + R K K L E +KL+ F ++K + E KL
Sbjct: 3075 SSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLY 3134
Query: 5202 EAL-----------LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
+ L L D L+ + L +++ QL + ++ ++ + N D +
Sbjct: 3135 KVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEA 3194
Query: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR--- 5307
FQ+++ +++ + ++ ENS + + V+ +L+E D +L+ S R
Sbjct: 3195 FQEQVWAEMCSIKAVTAIEKQREENS-SEASDVETKLREFE---DLQMQLNTSIDLRTNV 3250
Query: 5308 LEQALKQAEVFRDTVHMLLEWLSEAEQ-TLRFRGALPDDTEALQSLIDTHKEFMKKVEEK 5366
L A + +++ V +E ++ E + +R + + E+L+ ++K EE
Sbjct: 3251 LNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP-------LRKQEEL 3303
Query: 5367 RVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVA 5426
V + E + + P+ +++ + + ++ + K + E L
Sbjct: 3304 ESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC 3363
Query: 5427 NAELLEELLAWIQWAETTLIQRDQEPIP-------QNIDRVKALIAEHQTFMEEMTR 5476
++ E++ + ET L Q +P + +++ KAL++ + EE+ +
Sbjct: 3364 YRKMEEDIYTNLSKMETVLGQ-SMSSLPLSYREALERLEQSKALVSNLISTKEELMK 3419
Score = 118 bits (296), Expect = 2e-25
Identities = 580/3196 (18%), Positives = 1207/3196 (37%), Gaps = 488/3196 (15%)
Query: 2111 VVKDIEG-FMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQ 2169
++K+ E F EE + LRE + Q Q+E + K+ E+ + L+
Sbjct: 975 LIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKS--QQEVKRLLKDYEQKIERLLKC 1032
Query: 2170 ETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG 2229
+E + A K + +T+ + GG + P + + S EK T
Sbjct: 1033 ASEIHMTLQPTAGGTSKNEGT---ITTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKF 1089
Query: 2230 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE------- 2282
+ P L ++ M K + S + + + L + +T +
Sbjct: 1090 SLASVLRP--LQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDR 1147
Query: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE-----FESWLERSE 2337
LQ KL +L+ + +++A K+ + + +L+ + D K+ L+ E
Sbjct: 1148 SSSCLQAKLTDLQVIKN----ETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERE 1203
Query: 2338 KELE-NMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 2396
+EL+ ++ S ET L+ S + L + I G ++D + ++ +
Sbjct: 1204 RELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRN 1263
Query: 2397 PS--------------EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNS 2442
E GN V +L LH+ + + G H+ Q S
Sbjct: 1264 IQDSIAKQIEICNRLEEPGNFVLKELHPFD-----LHAMQNIILKYKTQFEGMNHRVQRS 1318
Query: 2443 ADSLQAW------MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 2496
D+L+A ++ + + E + +D ASD V QE T K + E+ + + L
Sbjct: 1319 EDTLKALEDFLASLRTAKLSAEPV-TDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHL 1377
Query: 2497 QKVARDI-MEIEGEPAPDHRHVQETTDSIL-----SHFQSLSYSLAERSSLLQKAIAQSQ 2550
K + + M + D + D+ +H + E + LL+ I ++
Sbjct: 1378 DKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNN 1437
Query: 2551 SVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM 2610
+ ++++ + I ++ L+ V ++ +++L K+ + +K L+
Sbjct: 1438 ELLKNIQDVQSQISKI--GLKDPTVPAVKHR--KKSLIRLDKVLDEYEEEKRHLQEMANS 1493
Query: 2611 VTRFMETADST-------TAAVLQGKLAEVSQRFEQ------LCLQQQEKESSLKKLLPQ 2657
+ F + + T T + + A V++ EQ L Q Q +S L L+ +
Sbjct: 1494 LPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQK 1553
Query: 2658 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ---------- 2707
E L EN + +A ++ + + ++N ++ Q
Sbjct: 1554 EESVISLQASYMG-KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
Query: 2708 -------------ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTE--LQKTVKE 2752
LD E + G AL L ++N+ ++TE LQK
Sbjct: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
Query: 2753 R--EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQI----EHLKS 2806
+ E+D +E+L + F + + E + + +E + + +E I EH++
Sbjct: 1673 QLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQK 1732
Query: 2807 LLDDWA-------SKGTLVEEINCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVG 2856
L + S L E+++ T + E+L+ ++ DS + + L + +
Sbjct: 1733 CLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSL-EIFTKLEEIQQQI- 1790
Query: 2857 SVNGYHTCKDL-TEIQC---DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
+ H+ L +I C ++S++ +YE + + + ++ LQ +++ ++ + +
Sbjct: 1791 -LQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKL--LNDQCKNF 1847
Query: 2913 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2972
W + + LK S K+ K Q S+ FL LE + KI++V L +
Sbjct: 1848 NDWFSNIKVNLKECFESSETKKSVEQKLQKLSD--FLT-LEGRNSKIKQVDSVLKHVKKH 1904
Query: 2973 YPNSQEAE--NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM- 3029
P + E +W QE E+ + AR ++LE+S L Q LR WL
Sbjct: 1905 LPKAHVKELISWLVGQE---FELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTN 1961
Query: 3030 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE---QLNEAAQGI-LTGPGD 3085
++E G+ P ++ + + +R+Q E QLN + + T +
Sbjct: 1962 QEEKWKGMEEP-----------GEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEE 2010
Query: 3086 VSLSTSQVQKELQSINQKW--VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ + + + Q++ ++ +E DKL Q + +L D+ ++ +
Sbjct: 2011 IIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQ---------SFNDLAHDVIHWIKEIK 2061
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE- 3202
+ L V + +SE + LE+ ++KE L E I E +K
Sbjct: 2062 ESLMVLN---------------SSEGKMPLEERIQKIKEIILLKPEGDARI-ETIMKQAE 2105
Query: 3203 ------LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQ 3256
++K L ++ LA+ ++ + L +++ Q ++LR L + + +Q
Sbjct: 2106 SSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQ 2165
Query: 3257 AKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQ 3316
+ L+ ++QL+ ++F K + + + ++G LL + +
Sbjct: 2166 EAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECT---KNPSFSEEP 2222
Query: 3317 LVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED-CKAKMSELRVTLDP 3375
+E+K+ E L ++ D L +++ YQ V DL +++ K +S +D
Sbjct: 2223 WLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQ 2282
Query: 3376 VQLESSLLRSKAMLNEVEKRRSLLE-----ILNSAADILINSSEADEDGIRDEKAGINQN 3430
+ +E L + L E+E R SL + IL A + N+S + I+D+
Sbjct: 2283 IAVEEKLQK----LQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDD------- 2331
Query: 3431 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE 3490
++ Q K++E ++ AK ++E C N L+
Sbjct: 2332 ---------------------IKSLQCKQKDLENRLASAKQEME--------CCLNSILK 2362
Query: 3491 KLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV---KQRV 3547
R+ ++ + P + + T + E + + +L E+ + +E+ KQ
Sbjct: 2363 SKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLS 2420
Query: 3548 NSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLN 3607
+ M+N + +V E+ +Q +LD L Q+E++
Sbjct: 2421 LNAQESMKNT-----EDERKVNELQNQPLELDTML------------RNEQLEEIEKLYT 2463
Query: 3608 KIHVLKLDIEASE-AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELT 3666
++ K I+ E EC + E G L L + + L+ L K ++ Q +
Sbjct: 2464 QLEAKKAAIKPLEQTECLNK-TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV- 2521
Query: 3667 LGRVEDFYRKLKGLNDATTA-AEEAEALQWVVG-----TEVEIINQQLADFKMFQKEQVD 3720
+ DF L + + A + E+L+ VG T ++ I + +A + +K+ +
Sbjct: 2522 ---LRDFQEYLAAVESSMKALLTDKESLK--VGPLDSVTYLDKIKKFIASIEK-EKDSLG 2575
Query: 3721 PLQMKLQ----QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQE 3776
L++K + V + + L++S ++ LEH E++ + + KK +Q++ + E
Sbjct: 2576 NLKIKWENLSNHVTDMDKKLLES-----QIKQLEHGWEQVEQQ---IQKKYSQQVVEYDE 2627
Query: 3777 ALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATV 3836
K QD +S + L K P +A Q L L K
Sbjct: 2628 FTTLMNKVQDT---EISLQQQQQHLQLRLKSPEE-----RAGNQSMIALTTDLQATKHGF 2679
Query: 3837 DMLQAEGGRIAQSAELADREK--ITGQLESLESRWTEL----------LSKAAARQKQLE 3884
+L+ + + ++EK + + +L+ +W L + K R K E
Sbjct: 2680 SVLKGQ-AELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKE 2738
Query: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944
IL AK P L + + +Q K + A ++ +E+ A +
Sbjct: 2739 TIL-WAKNLLGELNPSIPLL---------PDDILSQIRKCKVTHDGILARQQSVESLAEE 2788
Query: 3945 VHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGE 4004
V V SLT+ E L+ ++ L+ +Y + + +++ L+ L F
Sbjct: 2789 VKDKV------PSLTT-YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFA 2841
Query: 4005 DEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL 4064
+ + E E + + L H A +E+ + ++ +
Sbjct: 2842 IIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNI 2901
Query: 4065 LKQTTGEEVLLIQEKLDGIKTR----YADITVTSSKALRTLEQARQLATKFQSTYEELTG 4120
++ E L ++++L +K R I T ++ ++ RQ K + EE
Sbjct: 2902 YEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADS 2961
Query: 4121 WLREVEEELATSGGQSPTGEQIPQFQQRQKELK---KEVMEHRLVLDTVNEVSRALLELV 4177
R E L E+I + R +K +V++ + V D + +
Sbjct: 2962 IQR--NELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIG---------L 3010
Query: 4178 PWRAREGLDKLVSDANEQYKLVSDTIGQ--RVDEIDAAIQRSQQYEQAADAELAWVAETK 4235
W + LD+L + E+ K + + I Q +E Q +A D ++ + E
Sbjct: 3011 NWDFSQ-LDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVV 3069
Query: 4236 RKLMALGP--IRLEQDQTTAQLQVQKAFSIDIIR---HKDSMDELFSHRSEIFGTCGEEQ 4290
K P RL + +++ K +II+ + D+ F + + E+
Sbjct: 3070 LKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEE 3129
Query: 4291 KTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQL 4350
L + ++++ + L +LE + ++NQ + +QL
Sbjct: 3130 NDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQ-----------------IKSQL 3172
Query: 4351 PSPA---IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ 4407
P ++ + ++ +++ +E + I + I Q +E N E VE K +
Sbjct: 3173 QQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQ-REENSSEASDVETKLR 3231
Query: 4408 KAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAE 4467
+ E++ Q+ + R L++A +T + + + +E++ +L + +IP
Sbjct: 3232 EFEDLQMQLNTSIDLRTNVLNDAYE---NLTRYKEAVTRAVESITSLEA-----IIIPYR 3283
Query: 4468 VDKIRECISDNKSATVEL-----EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL 4522
VD N ++E+ E+L+ + ++ E+L S K +Q+ +
Sbjct: 3284 VD------VGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELV 3337
Query: 4523 DQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS 4582
+ E KA+ E E ++L+ + K D+ L+ ++ + + S +
Sbjct: 3338 SKNSAMKEAFKAQETEAE-RYLENYKCYRKMEEDIYTNLSKMETV--LGQSMSSLPLSYR 3394
Query: 4583 IIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN 4642
+++E ++ + EEL +R + L C E + + K + + W +L
Sbjct: 3395 EALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLL 3454
Query: 4643 KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKE 4702
+ KE E+ Q + ++ LDN ++++L E+ +
Sbjct: 3455 EAAKEWEMWCEELKQEWKFVSEEIEREAIILDN-----------------LQEELPEISK 3497
Query: 4703 FKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKL 4762
K + E+L+ + + + + + ++ L + +N+ E
Sbjct: 3498 TK-----EAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPES-------- 3544
Query: 4763 EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA--- 4819
GA+ + FQ E+ S +LL + + + ++++ E+ + H +++A
Sbjct: 3545 SGAVETVPAFQ----EITSMKERCNKLL---QKVQKNKELVQTEIQERHSFTKEIIALKN 3597
Query: 4820 --HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4877
Q T N A + E S + L+S L+ +E++++K + ++ T+
Sbjct: 3598 FFQQTTTSFQNMAFQDHPEKS--EQFEELQSILKKGKLTFENIMEKLRIKYSEMY-TIVP 3654
Query: 4878 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT------HMELYSQLKAK-- 4929
A+ S++E+ L ++ ++S R +++ ++E Q K+K
Sbjct: 3655 AE-IESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNI 3713
Query: 4930 ---EETYNQLLDK------------GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKM 4974
+E ++ D+ + + D G + ++ + Q++ VS +
Sbjct: 3714 EKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRA 3773
Query: 4975 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL-NIASPPSL-----ILNTVLSQIEE 5028
E R S+L +A E+ + L+ W+ L N A SL +TV +E+
Sbjct: 3774 ECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALED 3833
Query: 5029 --------HKVFAN----EVNAHRDQIIE-LDQTGNQLKFLSQK------------QDVV 5063
H +F + + D++ + + + NQ+ L QK DVV
Sbjct: 3834 SEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVV 3893
Query: 5064 LIKNLLVSVQSRWEKV 5079
I++ + S++ R K+
Sbjct: 3894 AIESEVKSMEKRVSKI 3909
Score = 115 bits (288), Expect = 1e-24
Identities = 496/2765 (17%), Positives = 1049/2765 (37%), Gaps = 322/2765 (11%)
Query: 1879 QLLKALEKDAKNLQKSLSSVSDTWNSRLL----HFQNAVEI-EKTKVL-NQHTQLEGRLQ 1932
++L E++ ++LQ+ +S+ + R QN V + E TK L + + GR+
Sbjct: 1475 KVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVL 1534
Query: 1933 DLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA-------------Q 1979
+L N IL + E V SL E+LK+ +AE + +
Sbjct: 1535 ELLKQYQNFKSILTTLIQKEE-SVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDK 1593
Query: 1980 LDALAFDIQFFISEHAQDLSPQQNRQMLRL------LNELQRSFQDILEQTAAQVDALQG 2033
++ + ++QF++++ P ++ + +NE + + L + A D L
Sbjct: 1594 INQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLF- 1652
Query: 2034 HLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQ--------QDLS 2085
+L+ + E K LQK + HQ E+ + + L H+ +T++ Q L
Sbjct: 1653 NLKNVIDEWTEKALQKME--LHQLTEEDRE---RLKEELQVHEQKTSEFSRRVAEIQFLL 1707
Query: 2086 ALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY 2145
+ +L+ ++ I N+ V K + G E N LS LRE L QAK Q
Sbjct: 1708 QSSEIPLELQVMESSILNKMEH---VQKCLTG--ESNCHALSG-STAELREDLDQAKTQI 1761
Query: 2146 EALQEETRVAQK--------ELEEAVTSALQQ-------ETEKSKAAKELAENKKKIDAL 2190
+ + +LEE LQQ E + EL+E KK+ +++
Sbjct: 1762 GMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESV 1821
Query: 2191 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 2250
D + S + L L + D + + ++ + E K+
Sbjct: 1822 SDLFNTKKSVLQDHFSKL----------LNDQCKNFNDWFSNIKVNLKECFESSETKKSV 1871
Query: 2251 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK 2310
Q+L Q+ + L + + + Q L ++ + + + EL + L E EL+
Sbjct: 1872 EQKL--QKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKEL----ISWLVGQEFELE 1925
Query: 2311 QVQT--------LQDELQKFLQ---DHKEFESWLERSEKELENMHKGGSSPETLPSLLKR 2359
++++ L+D LQ+ L+ DH+ WL E++ + M + G E L R
Sbjct: 1926 KMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALAR 1985
Query: 2360 QGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDAT---ERYT 2416
+ E V + NS KE E ++ + +AT +RY
Sbjct: 1986 KREQFE-----------------SVAQLNNSLKEYGFTEE-----EEIIMEATCLMDRYQ 2023
Query: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
L + + + +L + F + A + W++ + ++ +L+ + P L+E++
Sbjct: 2024 TLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESL-MVLNSSEGKMP--LEERI 2080
Query: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
K++ E +E + K A E AP VQ+T I + + + + +
Sbjct: 2081 QKIKEIILLKPEGDARIETIMKQA------ESSEAP---LVQKTLTDISNQWDNTLHLAS 2131
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
S +K + + + +S E L + E+++ E +L G +QE A K+
Sbjct: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG--FALQHG-LQEKKAQLKIYKKF 2188
Query: 2597 IARQKSSLEATREMVTRFMETADST-TAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2655
+ + + +E+ ++ + T + + E+ E L Q Q+ +L +
Sbjct: 2189 LKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHV 2248
Query: 2656 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQD---ITHFFQQIQELNLEMEDQQENLDT 2712
+ + ++ L ++N S+ S + D + Q++QEL + Q L
Sbjct: 2249 REHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKK 2308
Query: 2713 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR 2772
+ L + ++ +D +++L+ +L+ + +++ C L+ K R
Sbjct: 2309 ILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECC---LNSILKSKR 2365
Query: 2773 TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW-ASKGTLVEEINCKGTSLENL 2831
+ +K K T TS +E ++ ++ L +DW +K + VE K SL N
Sbjct: 2366 STEKKGKFTLPGREKQATS-DVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSL-NA 2423
Query: 2832 IMEITAPDSQGKTGSILPSV--------GSSVGSVNGYHT--------CKDLTEIQC--D 2873
+ + + K + + + +T K L + +C
Sbjct: 2424 QESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNK 2483
Query: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
L +G LQA++ + + + + E V SM A+ T
Sbjct: 2484 TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALL--T 2541
Query: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW 2993
E++K + +L ++++ I+K K++L L + W+ + +
Sbjct: 2542 DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKI---------KWENLSNHVTDMD 2592
Query: 2994 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 3053
++ E + +QLE + Q + + ++E + ++ + L Q+Q
Sbjct: 2593 KKLLESQI---KQLEHGWEQVE--QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQ 2647
Query: 3054 QVQFMLKEFEARRQQHE--------QLNEAAQGILTGPGDVSLSTSQVQKE-------LQ 3098
+Q LK E R Q + +L G ++ + +KE +
Sbjct: 2648 HLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGIN 2707
Query: 3099 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEA 3158
++ ++W L +QI + +++ + +L A + +I P+
Sbjct: 2708 NLKKQWETLEPLHLEAENQIKKCDIRNKMKETILW-------AKNLLGELNPSIPLLPDD 2760
Query: 3159 VKQQLEETSEIRSDLEQLDHEVKE-AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217
+ Q+ + + V+ A+ + D++ L Y +L LE + Q L
Sbjct: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSL--TTYEGSDLNNTLEDLRNQYQML 2818
Query: 3218 EDLAADRINRLQAAL-------ASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
+ R +L+ L A ++FQ M E T + + A + L+
Sbjct: 2819 VLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLE 2878
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
+ +E +E ++ H I E L+V E+ L++QL LK
Sbjct: 2879 ASQKELQEIDSGISTHLQELTNIYEE-----LNV---FERLFLEDQLKNLK--------- 2921
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLR---SKA 3387
R +R++ +Q VE + + K S L+ D +Q LL +K
Sbjct: 2922 --IRTNRIQRFIQNTCN---EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKG 2976
Query: 3388 MLNEVEKRRSLLEILNSA-ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLE 3446
+ E+ + L + +L D G+ + + ++Q V E K LE
Sbjct: 2977 VKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFE----KEKELE 3032
Query: 3447 EMTQRLREFQE---SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALE 3503
E ++L F+E ++ + K+ Q++ + +A + + Q + Q +E
Sbjct: 3033 EKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIE 3092
Query: 3504 PQVDYLRNFTQGLVEDAP-DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG 3562
+ L E+ D S + + Q ++ +E ++ + + + +++E + +
Sbjct: 3093 KAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQN--MVLELSPKELD 3150
Query: 3563 QFHC--RVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
+ +C ++ L + +L I + +Q++ ++ F ++ I+A
Sbjct: 3151 EKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVT 3210
Query: 3621 AECRHMLEEEGTLDLLGLK-RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679
A + E + K RE E L Q ++L + D Y L
Sbjct: 3211 AIEKQREENSSEASDVETKLREFEDLQMQL----------NTSIDLRTNVLNDAYENLTR 3260
Query: 3680 LNDATTAAEEA----EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3735
+A T A E+ EA+ ++ V++ N + + +K+ + L+ + + L +
Sbjct: 3261 YKEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQ--EELESTVAHIQDLTEK 3316
Query: 3736 LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWL 3795
L + + +Q L++ ++E+ ++ + + + + + + L + ++ E + + L
Sbjct: 3317 LGMISSPEAKLQ-LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNL 3375
Query: 3796 ADTEELIA-NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELAD 3854
+ E ++ + Y+ ++++ K L L K + L+ + D
Sbjct: 3376 SKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND 3435
Query: 3855 REKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP---ISDFLSVTEKKL 3911
+ + +L +W LL A + E++ K E E I D L ++
Sbjct: 3436 GICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEI 3495
Query: 3912 ANSEPVGTQTAKIQQQIIRHKALEEDIENH---ATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
+ ++ T T ++ + + E++E T + Q ++ Q++ + E
Sbjct: 3496 SKTKEAAT-TEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
Query: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
++I S++ R +++ + + L+ + F ++ + + N+ +
Sbjct: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSF-------- 3606
Query: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLL----IQEKLDGIK 4084
Q++ + H + EE+ + K +N L+ E + I+ +++ +
Sbjct: 3607 -QNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECR 3665
Query: 4085 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQ 4144
DI S + + + K EE+ L VE+ L + I +
Sbjct: 3666 KALEDIDEKISNEVLKSSPSYAMRRKI----EEINNGLHNVEKML------QQKSKNIEK 3715
Query: 4145 FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 4204
Q+ QK++ E+ L+ ++ + ++E P +A+E +D L+ +QY+ VS
Sbjct: 3716 AQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPF-QQYQQVSQRAE 3774
Query: 4205 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI----RLEQDQTTAQLQVQKA 4260
R +++ A + ++Y + AW+ T L L +T Q+ ++ +
Sbjct: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDS 3834
Query: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320
+ H MD S IF T E T+S+ + ++ L + L
Sbjct: 3835 EQKHNLLHSIFMD--LEDLSIIFET---------DELTQSIQELSNQVTALQQKIMESLP 3883
Query: 4321 RAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH 4380
+ Q + + E+ + + L S I + + + E+I K
Sbjct: 3884 QIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKT 3943
Query: 4381 IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK--EEVRQRALALDEAVSQSTQIT 4438
I +++ +L+ P+ G +Q+ + IK E V Q L + V + T
Sbjct: 3944 IAEIVSYQVELR--LPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQT--N 3999
Query: 4439 EFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRR 4498
E+ ++IE + + L N S++ + + P + DK+ + E+E+++ +L +R
Sbjct: 4000 EWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-------EIERMEKQILSLNQR 4052
Query: 4499 GEELI 4503
E+L+
Sbjct: 4053 KEDLL 4057
Score = 108 bits (269), Expect = 2e-22
Identities = 158/821 (19%), Positives = 326/821 (39%), Gaps = 59/821 (7%)
Query: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE-LMLKKATDETDRDIIREPLTELKHLWEN 4750
+V +QL + + VE+ + + KL +GE L L A + + + +L+ + ++
Sbjct: 4667 SVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYA--------LLQEVYKLEDVLDS 4718
Query: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV-IEVELAK 4809
+ + R +L + Q L+ ++ + +E L KV ++ ++
Sbjct: 4719 MWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIEN 4778
Query: 4810 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT---EE 4866
H V ++A ++ + A L S L+ W + + EE
Sbjct: 4779 HKVFFQKLVADMLLIQAYS--------------AKILPSLLQNRETFWAEQVTEVKILEE 4824
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926
+ +Q LQ E ++ L + L ++ P+ L E E+L + Y Q+
Sbjct: 4825 KSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQI 4884
Query: 4927 K----AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
K K Q L++G+ ++ S S + E +A LE++W ++ K++ +L+
Sbjct: 4885 KRNIGGKHARLYQTLNEGKQLVA----SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL----ILNTVLSQIEEHKVFANEVNA 5038
L + + WL ++ +LN SL L+T+ S I F+ EV+
Sbjct: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
Query: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098
+ GNQL L ++ D ++ L + +W ++ + + L +
Sbjct: 5001 KSSLKTAVISIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
Query: 5099 QFHEAWKKLIDWLEDAESHLDSE--LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 5156
+A ++I W+ + E E + + ++K L KHKEF+ + KQ + D
Sbjct: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF-- 5117
Query: 5157 RTGRALKEKTLLPEDSQKLD-----NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 5211
++L + + +S++ + LGE+ +W V G + LE+ L +
Sbjct: 5118 -VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESE 5176
Query: 5212 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRE 5271
+ +Q L +WL E +L Q + + L+D + + +L ++ + LK+S
Sbjct: 5177 NKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDI-ENQLAIKSKALDELKQSYLT 5235
Query: 5272 LIENS----RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
L + D + + Q+ S+ V +L S QS L++ +++ + M +
Sbjct: 5236 LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIR 5295
Query: 5328 W---LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 5384
+ + ++ + L E LQSL D + E+ + + + + +
Sbjct: 5296 FWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEII 5355
Query: 5385 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 5444
C T K W + +A +++ Q + + A A L ++ + Q A +
Sbjct: 5356 EEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANIS 5415
Query: 5445 LIQRD-QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484
+ + E +P + +K L + Q E + +DR+
Sbjct: 5416 MSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
Score = 105 bits (263), Expect = 1e-21
Identities = 377/2035 (18%), Positives = 792/2035 (38%), Gaps = 291/2035 (14%)
Query: 1957 DSLNLCLQQYEDLKQPMAERKAQ----------LDALAFDIQFFISEHAQDLSPQQNRQM 2006
+ L Q EDL+Q + + Q LD F++ +S+ S ++ +M
Sbjct: 4496 EELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLS--SVEEMLEM 4553
Query: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNT-----CHQQLEDL 2061
RL E Q E A ++ L L + + L +NT C L+ +
Sbjct: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQ-V 4612
Query: 2062 CSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEE 2121
C + +A A + ++ + L + Q+++K L + TS + +I G
Sbjct: 4613 CL---EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISG---- 4665
Query: 2122 NQTKLSPRELTALREKLHQAKEQYEALQE-ETRVAQKELEEAVTSALQQETEKSKAAKEL 2180
++ E+L +A L+ E+RVA+ L+ E E+ L
Sbjct: 4666 ----------QSVAEQLQKADAYTVELENAESRVAK----------LRDEGERLHLPYAL 4705
Query: 2181 AENKKKIDALLD--W---------VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG 2229
+ K++ +LD W ++S + Q L GM +L EK A G
Sbjct: 4706 LQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA----HG 4761
Query: 2230 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQ 2289
++ ++ L Q E K Q+L++ ++ SA+ + T +Q+ +
Sbjct: 4762 HLKQTKSKVALQAQIENHKVFFQKLVADM--LLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
Query: 2290 KLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSS 2349
K+ E K + +LQ LQ +EF+ EK+LE +
Sbjct: 4820 KILEEKSRQCGM----------------KLQSLLQKWEEFDENYASLEKDLEIL------ 4857
Query: 2350 PETLPSLL---KRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE--PSEIGNLV 2404
TLPS+ + + E + ++ R + G K + + EGK+ S +
Sbjct: 4858 ISTLPSVSLVEETEERLVERISFYQQIKRNI---GGKHARLYQTLNEGKQLVASVSCPEL 4914
Query: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE--ANVEKLLS 2462
+ ++ E++ +L+ K L LL + +D L W+++ + N K S
Sbjct: 4915 EGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQS 4974
Query: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
V+ D ++ + + +E+ E + + ++ H++ET
Sbjct: 4975 LNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLL-----------HLKETDT 5023
Query: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
+ +L SLA+ I Q +QE L L ++E+ K ++ + S +
Sbjct: 5024 A------TLRASLAQFEQKWTMLITQLPDIQEKLHQL-----QMEKLPSRKAITEMISWM 5072
Query: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFME----------TADSTTAAVLQGKLAE 2632
T+ +D SS + ++ + E D ++LQ +
Sbjct: 5073 NNVEHQTS---DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCD 5129
Query: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2692
V + + E+ + L + + G L + +++ ++L S IT
Sbjct: 5130 VESK-------RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLES-------ITES 5175
Query: 2693 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR--------VQNLRKDFT 2744
+IQ LN +E Q+E L TL+ + +S LD CQ + + L++ +
Sbjct: 5176 ENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD-CQDIENQLAIKSKALDELKQSYL 5234
Query: 2745 ELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP---------TETSMSAK 2795
L+ +D +S ++L + R V T LK + S+ E +M
Sbjct: 5235 TLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTI 5294
Query: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855
+EH K ++ +E + C+ +L++L E A S+G + +G
Sbjct: 5295 RFWYCMEHSKPVV-------LSLETLRCQVENLQSLQDE--AESSEGSWEKLQEVIGKLK 5345
Query: 2856 GSVNGYHTCKDLTE-IQCDMSDVNLKYEKLGGVLHERQESLQAIL---NRMEEVHKEANS 2911
G C + E I+ + + ++ ++ + ++ + Q++L H EA +
Sbjct: 5346 G------LCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAA 5399
Query: 2912 VLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL---AG 2968
L+ E+K + L ++ +MS E + L ++++ +QK KEA +
Sbjct: 5400 RLKQQEAKFQQLANI-SMSGNNLAEILPPA-------LQDIKELQHDVQKTKEAFLQNSS 5451
Query: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 3028
+L P E+ + L+S +RA + ++ L A+ F+ SQ + +
Sbjct: 5452 VLDRLPQPAESSTHMLLPGPLHS-LQRAAYL----EKMLLVKANE---FEFVLSQFKDFG 5503
Query: 3029 MEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQH---EQLNEAAQGILTGPG 3084
+ E + G++ + + L+ Q K+ L A Q E LNE +
Sbjct: 5504 VRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-------- 5555
Query: 3085 DVSLSTSQVQ-KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ L S V K LQ++N++W+ T R S++ Q I + ++ + + + +
Sbjct: 5556 -LKLPLSDVAVKTLQNMNRQWIRATATALERCSEL-QGIGLNEKFLYCCEKWIQLLEKIE 5613
Query: 3144 QRLSVQSAISTQPEAVKQQLEE---TSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
+ L V A ++ PE ++QQ +E+ + D V ++ L D + +++
Sbjct: 5614 EALKVDVA-NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI- 5671
Query: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL-DDKQSQQAKN 3259
E K + +QG+ D + + Q F + L +L D A
Sbjct: 5672 TEFSKLTDRWQNAVQGVRQRKGD----VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK 5727
Query: 3260 CPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 3319
L + +S + E + + + + + + GE LLL+ + K ++ ++ +
Sbjct: 5728 GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDL-KTKESVGRRISQ 5786
Query: 3320 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QL 3378
L++ W+++ + A+ + + ++ + + +++L ++ KA+ DP+ +L
Sbjct: 5787 LQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSE------DPLPEL 5840
Query: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL 3438
L K ++ E+E+ S A N E ++ KA + +++ + E++
Sbjct: 5841 HEDLHNEKELIKELEQ---------SLASWTQNLKE-----LQTMKADLTRHV--LVEDV 5884
Query: 3439 QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS------NKNLEKL 3492
+E + ++ + ++++E + +F+ + C+ NK L+
Sbjct: 5885 MVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTA 5944
Query: 3493 RAQ-QEVLQALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSG 3550
+E+++ L+ ++ + F++ ++ G + +++ A E+ ++N
Sbjct: 5945 DISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-----EIDDKLNKI 5999
Query: 3551 CVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA-IGRDTDSLQSQI-------EDV 3602
++ + IG +++E F+ + LD + + + R L + +++
Sbjct: 6000 NDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEI 6059
Query: 3603 RLFLNKIHVLKLDIEASEAE-------CRHMLEEE----GTLDLLGLKRELEALNKQCGK 3651
+ L + L+ DIE A C +L + + +++ +L+++
Sbjct: 6060 QKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRN 6119
Query: 3652 LTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADF 3711
+ R+ ++E T + F D +AE A ++L F
Sbjct: 6120 ICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRF 6179
Query: 3712 KMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRI 3771
+ FQ+ Q+ +L+ +N + L + D L+ + E N RW+ L ++V +
Sbjct: 6180 EAFQR-QIHERLTQLELINKQYRRLARENRTD-TASRLKQMVHEGNQRWDNLQRRVTAVL 6237
Query: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRL 3828
+L+ +F+ E +L WL + + + N + A+ K+ + +Q++
Sbjct: 6238 RRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI---T 6294
Query: 3829 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3883
L+ K +D L G ++ Q +E D I +LE L E+ + + ++L
Sbjct: 6295 LNTNK--IDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRL 6347
Score = 101 bits (251), Expect = 3e-20
Identities = 582/3278 (17%), Positives = 1245/3278 (37%), Gaps = 498/3278 (15%)
Query: 2091 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL----SPRELTALREKLHQAKEQYE 2146
Q+ +++ ++ +Q +K++ + +L S +EL + + Q Q E
Sbjct: 813 QAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRE 872
Query: 2147 ALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206
+ E + K E + S + + KA +EL N + D S+ +
Sbjct: 873 SPGE---LISKHKEALIISNTKSLAKYLKAVEELKNNVTE-----DIKMSLEEKSRDVCA 924
Query: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMK-----ARHQELLSQQQNF 2261
+ +++ +D G + N KL+KQ K R + L+ + +
Sbjct: 925 KWESLHHELSLYVQQLKIDIEKGKLSDNIL--KLEKQINKEKKLIRRGRTKGLIKEHE-- 980
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK 2321
A S + L Q H++ + L EL E+ + +Q E + + ++ + ++++
Sbjct: 981 --ACFSEEGCLYQLNHHM---------EVLRELCEELPSQKSQQEVK-RLLKDYEQKIER 1028
Query: 2322 FLQDHKEFESWLE-------RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDL 2374
L+ E L+ ++E + G P + K S + + + +
Sbjct: 1029 LLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEK-AMEPTM 1087
Query: 2375 RFVTISGQKVLDMENSFKEGKEPSEIGNLVK--DKLKDATERY---------TALHSKCT 2423
+F S + L E S E + I +L++ D +D E + + S+
Sbjct: 1088 KFSLASVLRPLQ-EESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEED 1146
Query: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
R S L L +N D+ + +E ++D P V++E+ ++ +
Sbjct: 1147 RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDI--KKPFVIKERDTLKERER 1204
Query: 2484 EELAEHQVPVEKLQKVARDIMEIE-------GEPAPDHRHVQE-----TTDSILSHFQSL 2531
E +E L+ R ++ +E G P H+ + D I H +++
Sbjct: 1205 ELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNI 1264
Query: 2532 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2591
S+A++ + + V + L +L Q +I +
Sbjct: 1265 QDSIAKQIEICNRLEEPGNFVLKELHPF---------DLHAMQ------NIILKYKTQFE 1309
Query: 2592 KLKQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKES 2649
+ + R + +L+A + + + TA + V L +V+Q L ++ +E E
Sbjct: 1310 GMNHRVQRSEDTLKALEDFLAS-LRTAKLSAEPVTDLSASDTQVAQE-NTLTVKNKEGEI 1367
Query: 2650 SLKKLLPQAEMFEHLSGKLQQF-MENKSRMLASGNQPDQDITHFFQQIQELN---LEMED 2705
L K + +HL L+ M K + + F ++ E + ++ E
Sbjct: 1368 HLMK-----DKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEF 1422
Query: 2706 QQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQK---------TVKEREKD 2756
+EN L +C F ++ + ++N++ +++ K VK R+K
Sbjct: 1423 TEEN--------KLLEACIF-----KNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
Query: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT 2816
+ LDE+ + R Q E S+P + K + +Q ++ L ++ +K
Sbjct: 1470 LIRLDKVLDEYEEEKRHLQ----EMANSLPHFKDGRE-KTVNQQCQNTVVLWEN--TKAL 1522
Query: 2817 LVEEINCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871
+ E + G LE L I Q K S++ S +G N K + EI+
Sbjct: 1523 VTECLEQCGRVLELLKQYQNFKSILTTLIQ-KEESVISLQASYMGKEN---LKKRIAEIE 1578
Query: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVH-----KEANSVL-QWLESKEEVLKS 2925
+ N E + + ++ ++LQ LN+M+ KEAN ++ +WL+ E K+
Sbjct: 1579 IVKEEFNEHLEVVDKI-NQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINE---KT 1634
Query: 2926 MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI 2985
D + + + + + K + E + + +QK++ + E+ +++
Sbjct: 1635 EDYYENLGRALALWDKLFNLKNVIDEWTEKA--LQKMEL----------HQLTEEDRERL 1682
Query: 2986 QEELNSRWERATEVT--VARQRQLEESASHLACFQAAESQLRPWLMEKE----------L 3033
+EEL ++ +E + VA + L +S+ Q ES + + +
Sbjct: 1683 KEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA 1742
Query: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQH--EQLNEAAQGILTGPGDVSLSTS 3091
+ G L D + Q + +LK +L E Q IL + L +
Sbjct: 1743 LSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLEN 1802
Query: 3092 QV---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV 3148
Q+ EL + +++ ++D N++ S V + +LL D + + V
Sbjct: 1803 QIGCLTPELSELKKQYESVSDLFNTKKS------VLQDHFSKLLNDQCKNFNDWFSNIKV 1856
Query: 3149 QSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK 3205
+ K+ +E+ + SD LE + ++K+ ++ + + + ++K EL
Sbjct: 1857 NLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVK-ELIS 1915
Query: 3206 RLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAK 3265
L L+ +E + R L+ +L + Q LR WL +++ + K
Sbjct: 1916 WLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEK 1975
Query: 3266 LERL-QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEK-RTLQNQLVELKNH 3323
E Q+ ++ E+F+ ++ E E E +++ ++ +TL QL E++
Sbjct: 1976 TELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEE- 2034
Query: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
E+ T D Q + D++ WI++ K + L + + LE +
Sbjct: 2035 -EDKLLPTED------------QSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQ 2081
Query: 3384 RSKAMLNEVEKRRSLLEILNSAADI----LINSSEADEDGIRDEKAGINQNMDAVTEEL- 3438
+ K ++ + + +E + A+ L+ + D D + + E+L
Sbjct: 2082 KIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLL 2141
Query: 3439 -------QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEK 3491
Q+K L M L++ QE+ ++ ++ K QL+I+ K L+K
Sbjct: 2142 LEGEKYLQSKE-DLRLMLIELKKKQEAGFALQHGLQEKKAQLKIY---------KKFLKK 2191
Query: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551
+ +L+ L+ Q +YL T+ +++ +LE+K S
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKN-----------------PSFSEEPWLEIKHLHESLL 2234
Query: 3552 VMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAI-------GRDTDSLQSQIEDVR 3603
+++ ++ + H R + + + DL+ LD D +++ +++ ++
Sbjct: 2235 QQLQDSVQNLDG-HVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQ 2293
Query: 3604 LFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQL 3663
N++ + ++ A + + + ++ +K ++++L + L R + ++++
Sbjct: 2294 ELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEM 2353
Query: 3664 ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVE--IINQQLADFKMFQKEQVDP 3721
E L + R + T E +A V + E + + D+++ + V+
Sbjct: 2354 ECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEM 2413
Query: 3722 LQMKLQQVNGLGQ----------GLIQSAGKDCDVQGLEHDMEEINARWNTLN-KKVAQR 3770
K +N +Q+ + D +EEI + L KK A +
Sbjct: 2414 AMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIK 2473
Query: 3771 IAQLQEAL---------LH-CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
+ E L LH G L+ LL + LI +K ++Y V++ Q
Sbjct: 2474 PLEQTECLNKTETGALVLHNIGYSAQHLDNLL------QALITLKKNKESQYCVLR-DFQ 2526
Query: 3821 E-----QKLLQRLLDDRKAT-VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3874
E + ++ LL D+++ V L + +A EK L +L+ +W L +
Sbjct: 2527 EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSN 2586
Query: 3875 KAAARQKQLEDILV-------------LAKQFHETAEPISDFLSVTEKKLANSEPVGTQT 3921
K+L + + + K++ + +F ++ K + Q
Sbjct: 2587 HVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQ 2646
Query: 3922 AKIQQQIIRHKALEEDIENHA-----TDVHQAVKIGQS---------LSSLTSPAEQGVL 3967
+Q +R K+ EE N + TD+ QA K G S + + E+ L
Sbjct: 2647 QHLQ---LRLKSPEERAGNQSMIALTTDL-QATKHGFSVLKGQAELQMKRIWGEKEKKNL 2702
Query: 3968 SEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKD 4027
+ I++L+ ++ ++ + + ++ E + W + +L+ +
Sbjct: 2703 EDGINNLKKQWETLEPLHLEAENQIKKCDIRNKM-----KETILWAKNLLGELNPS-IPL 2756
Query: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRY 4087
D+L + + ++ I+ R+++V+ + + + T E + L+ ++ +Y
Sbjct: 2757 LPDDILSQIRKCKVT-HDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQY 2815
Query: 4088 ADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE----ELATSGGQSPTGEQIP 4143
+ + S++ + LE + + F + + ++E E + T+ ++
Sbjct: 2816 QMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHV 2875
Query: 4144 QFQQRQKELKK-------EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQY 4196
+ QKEL++ + E + + +N R LE + L L N
Sbjct: 2876 TLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLE-------DQLKNLKIRTNRIQ 2928
Query: 4197 KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGP-----IRLEQDQT 4251
+ + +T +E++ I+ +Q+ + A +R + L ++ E
Sbjct: 2929 RFIQNTC----NEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984
Query: 4252 TAQLQVQKAFSIDIIRHKDSMDEL-----FSHRSEIFGTCGEEQKTVLQEKTESLIQQYE 4306
+L K + +++ K D + FS ++ E++K L+EK I+Q +
Sbjct: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKE-LEEK----IKQLD 3039
Query: 4307 AISLLNSERYARLERAQVL---VNQFWETYEELSPWIEETRALIAQLPSPAIDH-----E 4358
+ + A L + + + + + E + E+R L AQ+ S I+ +
Sbjct: 3040 TFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCD 3099
Query: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418
++ ++ E + +S E + +L+I +LN EE + + Y+ +NM ++
Sbjct: 3100 EIIKKLNENKTFDDSFKEKE-----ILQI-----KLNAEENDKL---YKVLQNMVLELSP 3146
Query: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE----C 4474
+ LDE Q DK+E L L + S+L+ P LI E+ I+ C
Sbjct: 3147 K------ELDEKNCQ--------DKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC 3192
Query: 4475 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQD---KLDQMVFFWED 4531
+ + E+ ++ + A++++ EE S+ +D + +E +D +L+ + +
Sbjct: 3193 EAFQEQVWAEMCSIK-AVTAIEKQREE--NSSEASDVETKLREFEDLQMQLNTSIDLRTN 3249
Query: 4532 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIK-DTQDIVHDLESPGIDPSIIKQQVEA 4590
+ A E ++ + + A + + A++ + D + LE P +++Q E
Sbjct: 3250 VLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP------LRKQEEL 3303
Query: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE 4650
T+ D L E+L G PE + + + N KE +
Sbjct: 3304 ESTVAHIQD-LTEKL--------------GMISSPEAKLQLQYTLQELVSKNSAMKEAFK 3348
Query: 4651 KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-----MPPVGTDLNTVKDQLNEMKEFKV 4705
E + ++ + M + + + K+ T M + ++L + K
Sbjct: 3349 AQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVS 3408
Query: 4706 EVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE---------PLTELKHLWENLGEKIA 4756
+ + E+ KL L+ + T+ +++ L E WE E++
Sbjct: 3409 NLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELK 3468
Query: 4757 HR----QHKLEGALLALGQFQHALEELMSW--LTHTEELLDAQRPISGDPKVIEVELAKH 4810
++E + L Q L E+ TEEL + + + +E K
Sbjct: 3469 QEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVE----KQ 3524
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
+L +L +++ V ++ + A + +S++ R + LQK ++ ++
Sbjct: 3525 QLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKL-------LQKVQKNKEL 3577
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
+Q+ +Q+ F EI + L Q + S + E+ + EL S LK +
Sbjct: 3578 VQTEIQERHSFTKEI----IALKNFFQQTTTSFQNMAFQDHP-EKSEQFEELQSILKKGK 3632
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE-------- 4982
T+ +++K R+ K + ++ + + S++EE + LE
Sbjct: 3633 LTFENIMEKLRI------------KYSEMYTIVPAE---IESQVEECRKALEDIDEKISN 3677
Query: 4983 EALNLATEF--QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
E L + + + ++E N L E+ L S + E K +E++
Sbjct: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKS------KNIEKAQEIQKKMWDELDLWH 3731
Query: 5041 DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100
++ ELD + Q + NL++ Q ++++V QR+ R L+ A + +++
Sbjct: 3732 SKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ-QYQQVSQRAECRTSQLNKATVKMEEY 3790
Query: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH 5138
+ K W+E+ SHL ++N D L+ H
Sbjct: 3791 SDLLKSTEAWIENT-SHL-----LANPADYDSLRTLSH 3822
Score = 97.4 bits (241), Expect = 4e-19
Identities = 130/690 (18%), Positives = 276/690 (40%), Gaps = 60/690 (8%)
Query: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQL 4899
G++ + L + + C E R + L++ L + + +EI+ +L + ++ L
Sbjct: 4597 GENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSL 4656
Query: 4900 SAS-KPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQ 4958
S G ++ EQL +L+ E +L D+G + L K E
Sbjct: 4657 QQSLNEISG--QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
Query: 4959 SVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS--LQEFINWLTLAEQSL---NIAS 5013
+L+ W ++ ++ E S TE Q LQ + + + ++ L ++
Sbjct: 4715 ---VLDSMWGMLRARYTELSSPF------VTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
Query: 5014 PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQ 5073
S + + +QIE HKVF ++ A L Q ++ +LL + +
Sbjct: 4766 TKSKV--ALQAQIENHKVFFQKLVADM--------------LLIQAYSAKILPSLLQNRE 4809
Query: 5074 SRWEKVV-------QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
+ W + V ++S + G L ++ ++F E + L LE S L S +
Sbjct: 4810 TFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE 4869
Query: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 5186
+++ ++S +++ ++ +GGK T+ G+ L PE L+ + ++ ++W
Sbjct: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE----LEGQIAKLEEQW 4925
Query: 5187 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL----AEDQPVHGDLDLVM 5242
++ K H+L+ L + L WL + L + V DLD +
Sbjct: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
Query: 5243 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 5302
+ ++ F KE+ +++ + G +L+ DT ++ L + +W +
Sbjct: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLP 5045
Query: 5303 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL--PDDTEALQSLIDTHKEFM 5360
Q +L Q + R + ++ W++ E ++ P ++ L+ HKEF
Sbjct: 5046 DIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFR 5105
Query: 5361 KKVEEKRVDVNSAVAMGEVILAVCHPDC----ITTIKHWITIIRARFEEVLTWAKQHQQR 5416
+++ K+ V+ V + L+ C + T + + ++ V + Q
Sbjct: 5106 MEMDYKQWIVD-FVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQH 5164
Query: 5417 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476
LE L + + ++ L W++ E L + P+++ V+ L+ + Q ++
Sbjct: 5165 LEQLLESITESENKIQILNNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAI 5221
Query: 5477 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRS 5506
K +D + ++Y +E P +E + S
Sbjct: 5222 KSKALDELKQSY--LTLESGAVPLLEDTAS 5249
Score = 83.2 bits (204), Expect = 7e-15
Identities = 385/2184 (17%), Positives = 812/2184 (37%), Gaps = 318/2184 (14%)
Query: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKR 3395
KD ++ Q V+D + W+ K K+ +L + + +SLL NE ++
Sbjct: 286 KDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNE--EK 343
Query: 3396 RSLLEILNSAADILINSSEADEDGIRDEKA--GINQNMDAVTEELQ-AKTGSLEEMTQRL 3452
+S L++L+ D+ E D+D ++ +A G++ ++A +L A L + L
Sbjct: 344 KSFLDVLSIKRDL----DELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWL 399
Query: 3453 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3512
+E +E + + + EK+ + ++ E + L F
Sbjct: 400 QEVEELMDEDLSASQDHSQAVTLIQ------------EKMTLFKSLMDRFEHHSNILLTF 447
Query: 3513 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3572
+ D + H V + E+K+R+N+ ++E K + +FH +
Sbjct: 448 ---------ENKDEN---HLPLVPPNKLEEMKRRINN---ILEKKFILLLEFHYYKCLVL 492
Query: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3632
+ ++ +LD +S++ +ED F+ + L ++ S +C + +
Sbjct: 493 GLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLAR-LDTSFQKCGEIYKN--- 548
Query: 3633 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEA 3692
L E + +NKQ + D K + + + ++ A
Sbjct: 549 -----LAGECQNINKQYMMVKS-----------------DVCMYRKNIYNVKSTLQKVLA 586
Query: 3693 LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQ 3747
W T VE + A F+ +KE++ + + L + AG DV
Sbjct: 587 C-WA--TYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVV 643
Query: 3748 G--LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3805
G + ++ +N RW L K QL+ L K QD +P ++ +++ +
Sbjct: 644 GSSISKELRRLNKRWRKLVSKT-----QLEMNLPLMIKKQD--QPTFD---NSGNILSKE 693
Query: 3806 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3865
+ + E+ + + Q + K + + G Q D EK+ GQ+E
Sbjct: 694 EKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTG----QLKVAKDVEKLIGQVEIW 749
Query: 3866 ESRWTELLSKA---AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3922
E+ +L + + ++ L+ ++ F E D L + + +++ E
Sbjct: 750 EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESF----- 804
Query: 3923 KIQQQIIRHKALEEDIENHATDVH-QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 3981
Q + L+ I+ V VK+ +L +LT + + K++ Q E+
Sbjct: 805 ----QHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQ---KEL 857
Query: 3982 QDRCCRKAALLDQALSNARLFGEDEVEVL--------NWLAEVEDKLSSVF------VKD 4027
+ R LL Q S L + + ++ +L VE+ ++V +++
Sbjct: 858 ESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEE 917
Query: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQA--IKNGQALLKQTTGEEVLLIQEKLDGIKT 4085
+DV + + H L+ + K ++++ N L KQ E+ L+ + + G+
Sbjct: 918 KSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIK 977
Query: 4086 RYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQF 4145
+ + + L L ++ LRE+ EEL + Q + +
Sbjct: 978 EH-EACFSEEGCLYQLNHHMEV--------------LRELCEELPSQKSQQEVKRLLKDY 1022
Query: 4146 QQRQKELKKEVME-HRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 4204
+Q+ + L K E H + T S+ + R G D + +
Sbjct: 1023 EQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGG------DPHSEAPFAKS--- 1073
Query: 4205 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----LEQDQTTAQLQVQKA 4260
+ A++ + ++ A+ L P++ +E+D + + + +
Sbjct: 1074 DNQPSTEKAMEPTMKFSLAS---------------VLRPLQEESIMEKDYSASINSLLER 1118
Query: 4261 FSI--DIIRH-----KDSMDELFSHRSEIFGTCGEEQKT---VLQEKTESLIQQYEAISL 4310
+ DI+ H K + FS + +C + + T V++ +T++ +++E ISL
Sbjct: 1119 YDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISL 1178
Query: 4311 -------------LNSERYARLERA---QVLVNQFWETYE---ELSPWIEETRALIAQLP 4351
+ ER ER Q+ +N E+ E L +E+ L+
Sbjct: 1179 KLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSD 1238
Query: 4352 SPA----------IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP-QLKELNPEEGE 4400
P ID +++ Q +R +++SIA+ ++L + G LKEL+P +
Sbjct: 1239 LPLHKMAIQGFHLIDADRIYQH---LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLH 1295
Query: 4401 MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRM 4460
++ K + + + V++ E L+ LE+ + LR
Sbjct: 1296 AMQNIILKYKTQFEGMNHRVQRS---------------------EDTLKALEDFLASLRT 1334
Query: 4461 PPLIPAEVDKIRECISDNKSA---TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4517
L V + SD + A T+ ++ + +K + + L + D E
Sbjct: 1335 AKLSAEPVTDLSA--SDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
Query: 4518 IQDK------LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
D LD + + E F + +L E + LL I+D Q +
Sbjct: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEE--FTEENKLLEACIFKNNELLKNIQDVQSQI 1450
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4631
+ +K + ++ + + D EE ++ + L EK V +
Sbjct: 1451 SKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT-VNQQC 1509
Query: 4632 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4691
WEN E LE+ ++ QYQ+ +++ L + ++
Sbjct: 1510 QNTVVLWENTKALVTECLEQCGRVLELLKQYQN-FKSILTTLIQKEESVISLQASYMGKE 1568
Query: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNH-----QGELMLKKATDETDRDIIREPLTELKH 4746
+K ++ E++ K E + ++K+N Q L K +E + +
Sbjct: 1569 NLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPP---FEKEANIIVD 1625
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W ++ EK L AL + + + W + ++ + D + ++ E
Sbjct: 1626 RWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEE 1685
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW--ESVLQKT 4864
L H ++ A ++ + ++ LE + SS+ +++E + +C ES
Sbjct: 1686 LQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME--SSILNKMEHVQKCLTGESNCHAL 1743
Query: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4924
+L+ L QA+ ++ ES L A P+ L E+++
Sbjct: 1744 SGSTAELREDLDQAK----------TQIGMTESLLKALSPSDSL------------EIFT 1781
Query: 4925 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
+L EE Q+L + M+L + G ++ L++++ VS +KS L++
Sbjct: 1782 KL---EEIQQQILQQKHSMILLENQIGC---LTPELSELKKQYESVSDLFNTKKSVLQD- 1834
Query: 4985 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044
+ + + + F +W + + +L S +V ++++ F + +I
Sbjct: 1835 -HFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLT-LEGRNSKIK 1892
Query: 5045 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAW 5104
++D +K K V + + LV + EK+ R + L+D+ ++ + +
Sbjct: 1893 QVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDH 1952
Query: 5105 KKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE 5164
+ L WL + E E K + F + L K+ +++ + +LKE
Sbjct: 1953 RNLRKWLTNQEEKWKGMEEPGE----------KTELFCQALARKREQFESVAQLNNSLKE 2002
Query: 5165 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 5224
E+ ++ + D++ T+ + E + + + F D ++ W+ ++
Sbjct: 2003 YGFTEEEEIIMEATC--LMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
Query: 5225 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-----SRDD 5279
+ L +V+N + ++ + K + +LK G IE +
Sbjct: 2061 KESL-----------MVLNSSEGKMPLEERIQKIKEII-LLKPEGDARIETIMKQAESSE 2108
Query: 5280 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 5339
V+ L ++S +WD L+ + S E+ L + E + + L L E ++
Sbjct: 2109 APLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
Query: 5340 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 5399
AL + ++ + +K+F+KK ++ + + G +L C + + + W+ I
Sbjct: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLE-CTKNPSFSEEPWLE-I 2226
Query: 5400 RARFEEVLTWAKQHQQRLETALSE 5423
+ E +L + Q L+ + E
Sbjct: 2227 KHLHESLLQQLQDSVQNLDGHVRE 2250
Score = 59.7 bits (143), Expect = 8e-08
Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 32/258 (12%)
Query: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4804
WE + + H + K++ L Q + + +WL TE E+L +P S D + IE
Sbjct: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6613
Query: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
+ + + + ++A V +VN + E L++ + +++ L+SRL ++ WE+
Sbjct: 6614 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6672
Query: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTG------GLPETAREQLDT 4918
+ L+ +L Q Q FH ++ LL L +++ + T L E RE +
Sbjct: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
Query: 4919 HMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975
EL Q+ +E N LL KG + E+K HV+ K++
Sbjct: 6733 EKELVERQPQVDMLQEISNSLLIKGH---------------GEDCIEAEEKVHVIEKKLK 6777
Query: 4976 ERKSKLEEALNLATEFQN 4993
+ + ++ + L QN
Sbjct: 6778 QLREQVSQDLMALQGTQN 6795
Score = 55.1 bits (131), Expect = 2e-06
Identities = 73/336 (21%), Positives = 140/336 (41%), Gaps = 21/336 (6%)
Query: 3858 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917
IT Q RW + ++ + +++ L +Q + I+ +L TE +L + +
Sbjct: 6547 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 6602
Query: 3918 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3973
+ IQ+ +R K L+E ++ A D ++A+ + ++SS T E L ++
Sbjct: 6603 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6660
Query: 3974 LQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD-- 4031
L + Q L Q+L + F + +L WLA +++ V D K D
Sbjct: 6661 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6720
Query: 4032 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT 4091
L + + L +E+V R+ VD + +LL + GE+ + +EK+ I+ + +
Sbjct: 6721 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6780
Query: 4092 VTSSKALRTLEQARQLATKFQSTYEELTG---------WLREVEEELATSGGQSPTGEQI 4142
S+ L L+ + A+ S E +G R + T+ G+ T ++
Sbjct: 6781 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRV 6840
Query: 4143 PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
P + Q+ V+ L L + + L L+P
Sbjct: 6841 PGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 6876
Score = 51.2 bits (121), Expect = 3e-05
Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 8/234 (3%)
Query: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
Q QQ A W+ +T+ +L L + D +L+V++ +I++ D+
Sbjct: 6574 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 6631
Query: 4275 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWE 4331
L + S+ F + T LQ + L +EA L ++ + F +
Sbjct: 6632 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6691
Query: 4332 TYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 4389
+ L W+ + R A + P D L + + E+ QL + + E +P +D L +I
Sbjct: 6692 LSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISN 6751
Query: 4390 QLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
L + + E+ EEK E Q++E+V Q +AL + ++ + F +
Sbjct: 6752 SLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDE 6805
Score = 50.8 bits (120), Expect = 4e-05
Identities = 48/216 (22%), Positives = 94/216 (43%), Gaps = 18/216 (8%)
Query: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDL--- 5240
D+W+ + + + + K+++ L Q + A+ WL K E +L + D+
Sbjct: 6556 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6612
Query: 5241 ---VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 5297
V L + K F V + S +E ++ ++T ++ +L++LS W+
Sbjct: 6613 ELRVKRLQEILKAFDTY----KALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA 6668
Query: 5298 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 5357
S + L Q+L Q + F LL WL+ A+ R + + D ++L++ +
Sbjct: 6669 QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRR 6727
Query: 5358 EFM---KKVEEKRVDVNSAVAMGEVILAVCH-PDCI 5389
E M K++ E++ V+ + +L H DCI
Sbjct: 6728 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCI 6763
Score = 50.8 bits (120), Expect = 4e-05
Identities = 45/199 (22%), Positives = 85/199 (42%), Gaps = 11/199 (5%)
Query: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 2365
EL ++ LQ+ D +WL+++E ELE M K S + + +KR +
Sbjct: 6565 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 6624
Query: 2366 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRL 2425
++K + V +S ++ L E+ E +E+ + +L+ + + A
Sbjct: 6625 AFDTYKALVVSVNVSSKEFLQTESP-----ESTEL----QSRLRQLSLLWEAAQGAVDSW 6675
Query: 2426 GSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE 2485
L L Q F + +L W+ + + +K +DP L E QL++E
Sbjct: 6676 RGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKE 6735
Query: 2486 LAEHQVPVEKLQKVARDIM 2504
L E Q V+ LQ+++ ++
Sbjct: 6736 LVERQPQVDMLQEISNSLL 6754
Score = 44.7 bits (104), Expect = 0.003
Identities = 43/238 (18%), Positives = 100/238 (42%), Gaps = 14/238 (5%)
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ--QAKNCPISAKLERLQSQLQE 3275
E + A ++ + QQ + TWL +++ K + ++ ++ +++
Sbjct: 6559 EMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR 6618
Query: 3276 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQ 3335
+E K+ + + + + L + P E LQ++L +L WE +
Sbjct: 6619 LQEILKAFDTYKALVVSVNVSSKEFLQTESP--ESTELQSRLRQLSLLWEAAQGAVDSWR 6676
Query: 3336 SRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK- 3394
L+ + + Q + ++L+ W+ K + + VT DP +LL + L ++EK
Sbjct: 6677 GGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT-DPKADPRALLECRRELMQLEKE 6735
Query: 3395 ---RRSLLEILNSAADILINSSEADEDGIRDEKAGI-----NQNMDAVTEELQAKTGS 3444
R+ +++L ++ L+ ++ +EK + Q + V+++L A G+
Sbjct: 6736 LVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGT 6793
Score = 41.6 bits (96), Expect = 0.024
Identities = 63/323 (19%), Positives = 125/323 (38%), Gaps = 52/323 (16%)
Query: 3626 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3680
M++ + + L +K+ L+ LN +T K + +LE+ +++ ++K L
Sbjct: 6560 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 6619
Query: 3681 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3740
+ A + +AL V +N +F + + LQ +L+Q++ L
Sbjct: 6620 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLL-------- 6664
Query: 3741 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE- 3799
W V L+++L+ C F + LL WLA +
Sbjct: 6665 -------------------WEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6705
Query: 3800 -ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858
A+ P A+ + + +E L++ L +R+ VDMLQ + D +
Sbjct: 6706 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 6765
Query: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
++ +E + +L R++ +D++ L T P S S E + P
Sbjct: 6766 EEKVHVIEKKLKQL------REQVSQDLMAL----QGTQNPASPLPSFDEVDSGDQPPAT 6815
Query: 3919 TQTA-KIQQQIIRHKALEEDIEN 3940
+ A + + + +R EE+ E+
Sbjct: 6816 SVPAPRAKFRAVRTTEGEEETES 6838
Score = 38.1 bits (87), Expect = 0.26
Identities = 50/230 (21%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 4570 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4629
I+H L ID +K + + ++E +EL+ R+L + + EK +
Sbjct: 219 IIHALRPDLIDMKSVKHRSNK-DNLREAFRIAEQELKIPRLLEPEDVDVVDPDEK-SIMT 276
Query: 4630 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4689
+ + ++ T +E K++DAM ++ LQ + +N
Sbjct: 277 YVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEN-------------- 322
Query: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749
+T + N + F + EK + L +K+ DE D+D + +L+ W+
Sbjct: 323 -DTYFKKYNSLLSF-----MESFNEEKKSFLDVLSIKRDLDELDKDHL-----QLREAWD 371
Query: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4799
L +I + KL AL L + +WL EEL+D S D
Sbjct: 372 GLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQD 415
Score = 38.1 bits (87), Expect = 0.26
Identities = 45/255 (17%), Positives = 97/255 (38%), Gaps = 13/255 (5%)
Query: 4638 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV--IKLCTMPPVGTDLNTVKD 4695
WE + K++ +Q Q + A+ WL T +++ M +D+ ++
Sbjct: 6558 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 6614
Query: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4755
++ ++E + + +N + L+ + E+ ++ L +L LWE +
Sbjct: 6615 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAV 6672
Query: 4756 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI--SGDPKVIEVELAKHHVL 4813
+ L +L+ F + L+ WL + DP+ + + L
Sbjct: 6673 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6732
Query: 4814 KNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
+ +++ Q V+ + + N LL G+D ++ + E L++ E+ Q
Sbjct: 6733 EKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI----EKKLKQLREQVSQDLM 6788
Query: 4874 TLQQAQGFHSEIEDF 4888
LQ Q S + F
Sbjct: 6789 ALQGTQNPASPLPSF 6803
Score = 33.5 bits (75), Expect = 6.5
Identities = 40/204 (19%), Positives = 86/204 (42%), Gaps = 23/204 (11%)
Query: 1835 AELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKS 1894
+++Q++ + K L+ LK T + ++ + L+ ++ LQ
Sbjct: 6607 SDIQEIELRVKRLQEILKAFDTY---------KALVVSVNVSSKEFLQTESPESTELQSR 6657
Query: 1895 LSSVSDTWNSRLLHFQNAVEIEK---TKVLNQHTQLEGRLQDLRAWVGN-KNLILNSKGS 1950
L +S W + Q AV+ + + L Q Q+L W+ + KN + +
Sbjct: 6658 LRQLSLLWEAA----QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT 6713
Query: 1951 NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDAL-AFDIQFFISEHAQDLSPQQNRQMLRL 2009
+ + D +L C ++ L++ + ER+ Q+D L I H +D + +
Sbjct: 6714 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK----- 6768
Query: 2010 LNELQRSFQDILEQTAAQVDALQG 2033
++ +++ + + EQ + + ALQG
Sbjct: 6769 VHVIEKKLKQLREQVSQDLMALQG 6792
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 203 bits (517), Expect = 4e-51
Identities = 661/3649 (18%), Positives = 1424/3649 (39%), Gaps = 486/3649 (13%)
Query: 1817 LRNIEMRTKQIQPL---ELNLAELQDLLCQAKVLERELKDLTTLVSQELECV--NQIIIS 1871
L+N+++RT +IQ N E + C R+ + T+ + +E + + N+++++
Sbjct: 2917 LKNLKIRTNRIQRFIQNTCNEVEHKIKFC------RQFHEKTSALQEEADSIQRNELLLN 2970
Query: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSD-----------------TWNSRLLH------ 1908
Q ++ K ++++ NL+ L+++ W+ L
Sbjct: 2971 Q------EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQV 3024
Query: 1909 FQNAVEIE-KTKVLNQHTQLEGRLQDLRAWVGNKNL--------ILNSKGSNSEIDVDSL 1959
F+ E+E K K L+ + G+ Q L + + +L +L + S+ E +
Sbjct: 3025 FEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNA 3084
Query: 1960 NLCLQQYEDLKQPMAERKAQLDA-LAFDIQFFISEHAQ-DLSPQQNRQMLRLLNEL---- 2013
+ Q+ E K E +L+ FD F E Q L+ ++N ++ ++L +
Sbjct: 3085 QILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLEL 3144
Query: 2014 ------QRSFQDILEQTAAQVDALQGHLQQMEQEAL-VKTLQKQQNTCHQQLEDLCSWVG 2066
+++ QD LE + ++ ++ LQQ L +K +Q +++ C E + W
Sbjct: 3145 SPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQV--WAE 3202
Query: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126
+ + ++A++K + + D++ + F + + ++ L
Sbjct: 3203 MC-----------SIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
Query: 2127 SP--RELTALREKLHQAKEQYEALQE---ETRVAQKELEEAVTSALQQETEKSKAAKELA 2181
+ LT +E + +A E +L+ RV EE++ L+++ E +
Sbjct: 3252 NDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHIQ 3311
Query: 2182 ENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG--YMGVNQAPEK 2239
+ +K+ + S + QL L + + A E T+ Y+ + K
Sbjct: 3312 DLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRK 3366
Query: 2240 LDKQCEMMKARHQELLSQQQNFI-LATQSAQAFLDQHG---HNL--TPEEQQMLQQKLGE 2293
+++ ++ + +L Q + + L+ + A L+Q NL T EE L+Q L
Sbjct: 3367 MEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRL 3426
Query: 2294 LKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE-------------- 2339
L+ + + + LK V L ++ L+ KE+E W E ++E
Sbjct: 3427 LRLRCTEN--DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAII 3484
Query: 2340 LENMH---------KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 2390
L+N+ K ++ E L LL + E+V + +T+ Q++ ++N
Sbjct: 3485 LDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQ---LLLTLLLQRIRSIQNV 3541
Query: 2391 FKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 2450
+ + ++ ER L K + + + + H F +L+ +
Sbjct: 3542 PESSGAVETVPAF--QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFF 3599
Query: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR----DIMEI 2506
Q + + + D EQ ++LQ L + ++ E + + R ++ I
Sbjct: 3600 QQTTTSFQNM----AFQDHPEKSEQF---EELQSILKKGKLTFENIMEKLRIKYSEMYTI 3652
Query: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEV 2566
PA V+E ++ + +S + + S S +++ +E + + V
Sbjct: 3653 V--PAEIESQVEECRKALEDIDEKISNEVLKSSP--------SYAMRRKIEEINNGLHNV 3702
Query: 2567 EQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2626
E+ L+ K + I++A K+ ++ S L V +E D A
Sbjct: 3703 EKMLQQKSKN------IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQ-DPGQAQEW 3755
Query: 2627 QGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD 2686
L Q+++Q+ + + + S L K + E + L + ++EN S +LA+ D
Sbjct: 3756 MDNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYD 3815
Query: 2687 --QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFT 2744
+ ++H +Q + +ED ++ + L + +L + + +Q L T
Sbjct: 3816 SLRTLSHHASTVQ---MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVT 3872
Query: 2745 ELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL-----EK 2799
LQ+ + E Q D+ V + +K E + +T + +KE+ E+
Sbjct: 3873 ALQQKIME---SLPQIQRMADD----VVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE 3925
Query: 2800 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2859
++H + +L++ + EI L LP G V
Sbjct: 3926 HLKHGEVILENIRPMKKTIAEIVSYQVELR------------------LPQTGMKPLPV- 3966
Query: 2860 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919
+ L + D+ L L V E+ E L+ ++ + E +E ++ Q L +
Sbjct: 3967 -FQRTNQL------LQDIKL----LENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNY 4015
Query: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN-SQE 2978
S++ MS + + Q E + L N K + + A +L + + QE
Sbjct: 4016 SAQF-SLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQE 4074
Query: 2979 AENWKKIQEELNSRWERATEVTVARQRQLEE--SASHLACFQA---------------AE 3021
E ++ + + E A +R+L S S+LA + AE
Sbjct: 4075 QEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAE 4134
Query: 3022 SQLRPWL--------MEKELMMGVLGPLSIDP--NMLNAQKQQVQFMLKEFEARRQQHE- 3070
+ W ME++ G + + + + Q + + Q E
Sbjct: 4135 PSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPEC 4194
Query: 3071 --QLNEAAQGILTGPGDVSLSTSQVQKELQS-INQKWVELTDKLNSRSSQIDQ------- 3120
+ N+ +G +L +S Q L+ + + E T+ L++ +Q+ +
Sbjct: 4195 SLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQ 4254
Query: 3121 ---AIVKSTQYQELLQDLSEKVRAVGQRLS-VQSAISTQPEAVKQQ-LEETSEIRSDLEQ 3175
A+ T ++ Q L +++ L+ ++ ++ E K Q L + + + E
Sbjct: 4255 ANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEA 4314
Query: 3176 LDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST 3235
L ++K + +++ +++ E++ +D+ L+ + P + E L ++ L++ +
Sbjct: 4315 LSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEP-EHQEALQPVNLSELESIVTER 4373
Query: 3236 QQFQQMFD-ELRTWLDDKQSQQA---KNCPISAKLERLQSQLQENEEFQKSLNQHSGSYE 3291
QF + D + + L+ K +Q K +AK Q +N+ Q+S S S +
Sbjct: 4374 PQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQES----SASNQ 4429
Query: 3292 VIVAEGE--SLLLSVPPGEEKRTLQNQLVELKNHWE-ELSKKTADRQSRLKDCMQKAQKY 3348
E + +LS P G+ Q EL + + L + + S + Y
Sbjct: 4430 ASSPENDVPDSILS-PQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMY 4488
Query: 3349 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE---VEKRRSLLEILNSA 3405
+ P E+ K ++L + ++ E+S L+++ + E + + L E+ +
Sbjct: 4489 NFRY----PTTEELKTYTTQL----EDLRQEASNLQTQENMTEEAYINLDKKLFELFLTL 4540
Query: 3406 ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKK 3465
+ L + E E + G Q + T L+ K L ++ + K +
Sbjct: 4541 SQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKK----GDLLKAMTWP 4596
Query: 3466 VEGAKHQLEIFDAL--------GSQACSNKNLEK----LRAQQEVLQALEPQVDYLRNFT 3513
E LE FD L + C +K+L+ R+ Q ++ L Q+ +
Sbjct: 4597 GENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSL 4656
Query: 3514 QGLVEDAPDGSDASQL---------LHQAEVAQQEFLEVKQRVNSGCVMMEN--KLEGI- 3561
Q + + S A QL L AE + + +R++ +++ KLE +
Sbjct: 4657 QQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVL 4716
Query: 3562 ----GQFHCRVREMFSQL---ADLDDELDGMGA---IGRDT------------DSLQSQI 3599
G R E+ S + D L GM IG++ +LQ+QI
Sbjct: 4717 DSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQI 4776
Query: 3600 EDVRLFLNKIHVLKLDIEASEAECRHML---EEEGTLDLLGLKRELEALNKQCGKLTERG 3656
E+ ++F K+ L I+A A+ L E + + + LE ++QCG +
Sbjct: 4777 ENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL 4836
Query: 3657 KARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQK 3716
+ E+ + +E L + + EE E E + ++++ ++ K
Sbjct: 4837 LQKWEEFDENYASLEKDLEILISTLPSVSLVEETE----------ERLVERISFYQQI-K 4885
Query: 3717 EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQE 3776
+ +L Q G+ L+ S LE + ++ +W +LNKK+ + +LQ
Sbjct: 4886 RNIGGKHARLYQTLNEGKQLVASVS----CPELEGQIAKLEEQWLSLNKKIDHELHRLQA 4941
Query: 3777 ALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQEQKLLQRLLDDR 3832
L H + + L WL ++ + K S + +++ I + +D++
Sbjct: 4942 LLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEK 5001
Query: 3833 KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQ 3892
+ + + G ++ E D + L E +WT L+++ Q++L + +
Sbjct: 5002 SSLKTAVISIGNQLLHLKE-TDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLP 5060
Query: 3893 FHETAEPISDFLSVTEKKLANSEPVGTQTA--KIQQQIIRHKA--LEEDIENHATD-VHQ 3947
+ + +++ E + ++ + V + ++ +++ + +HK +E D + D V+Q
Sbjct: 5061 SRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQ 5120
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
++ + + E+ +E + + ++ + RK L+Q L + E+++
Sbjct: 5121 SLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITE-SENKI 5179
Query: 4008 EVLN-WLAEVEDKLSSV----FVKDFKQDVLHRQHADH-LALNEEIVNRKKNVDQAIKNG 4061
++LN WL E++L ++ V ++ +L Q ++ LA+ + ++ K +++G
Sbjct: 5180 QILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESG 5239
Query: 4062 QALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 4121
L + T + + +K + T+ + + L+ + QL Y+E+
Sbjct: 5240 AVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQL-------YDEVNMM 5292
Query: 4122 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA 4181
+ S + E + + + L+ E + + EV L L P A
Sbjct: 5293 TIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVA 5352
Query: 4182 REGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241
E +++ + ++++ V+ I ++ + + +Q + Y A A + + + K L
Sbjct: 5353 -EIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQL 5411
Query: 4242 GPIRLEQDQTTA----QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK 4297
I + + LQ K D+ + K E F S + + ++
Sbjct: 5412 ANISMSGNNLAEILPPALQDIKELQHDVQKTK----EAFLQNSSVLDRLPQPAESSTHML 5467
Query: 4298 TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDH 4357
+ + + L + + +++QF ++ +E + LI +
Sbjct: 5468 LPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF----KDFGVRLESLKGLIMH------EE 5517
Query: 4358 EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV--EEKYQKAENMYAQ 4415
E L + ++ ++ +S H + L P ++ LN ++ + + +NM Q
Sbjct: 5518 ENLDRLHQQEKENPDSFLNH---VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQ 5574
Query: 4416 IKEEVRQRALALDEAVS-QSTQITE-----------FHDKIEPMLE-----TLENLSSRL 4458
+R A AL+ Q + E +KIE L+ +L L +
Sbjct: 5575 W---IRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQ 5631
Query: 4459 RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAA--- 4515
+ ++ AEV I + I+D+ T L+ L + ++ R E + S+ D+ A
Sbjct: 5632 KTYKMLEAEVS-INQTIADSY-VTQSLQLLDTT--EIENRPEFITEFSKLTDRWQNAVQG 5687
Query: 4516 -KEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIK--------D 4566
++ + +D +V W+D F +E +F D + LL+ +K
Sbjct: 5688 VRQRKGDVDGLVRQWQD-----------FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQ 5736
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
T+ ++H+L++ I +++ A T++ G L+ K
Sbjct: 5737 TRSLIHELKNKEIH--FQRRRTTCALTLEA---------------GEKLLLTTDLKTKES 5779
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---M 4683
V + I ++ ++W+++ E +++ + ++ Q + ++ + L V+K + +
Sbjct: 5780 VGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQ--VLKAQSEDPL 5837
Query: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
P + DL+ K+ + E+++ Q E++ + L + D +++E +
Sbjct: 5838 PELHEDLHNEKELIKELEQSLASWTQNLKELQTMKAD----LTRHVLVEDVMVLKEQIEH 5893
Query: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
L WE+L ++A R+ ++E L F +EL +WL E + IS + +
Sbjct: 5894 LHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMI- 5952
Query: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4863
E + ++ L + ++ + + G++L+++S A+ + +L +N W+ +
Sbjct: 5953 --EKLQKDCMEEINLFSENKLQ-LKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDV 6009
Query: 4864 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT-------GGLPETAREQL 4916
R ++L+ T Q + + L R+ES+LS KP + + EQ
Sbjct: 6010 IGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KPVVYDVCDDQEIQKRLAEQQ 6067
Query: 4917 DTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE-----QSVALLEQKWHVVS 4971
D ++ E +N + D +L D ++TE Q+ L+++W +
Sbjct: 6068 DLQRDIEQHSAGVESVFN-ICD-----VLLHDSDACANETECDSIQQTTRSLDRRWRNIC 6121
Query: 4972 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 5031
+ ER+ K+EE L +F + F +WL AE++ + ++ + +++ +
Sbjct: 6122 AMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEA 6181
Query: 5032 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD 5091
F +++ Q+ +++ +L ++ +K ++ RW+ + +R R L
Sbjct: 6182 FQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLR 6241
Query: 5092 DARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQP 5150
+ ++F + ++ WL + + L + S +D D QL+ FQ+ +
Sbjct: 6242 HFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLN---GFQQEITLNTN 6298
Query: 5151 VYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
D I G L +K+ P D+ +++ L E+ V G+ V R H+
Sbjct: 6299 KIDQLIVFGEQLIQKS-EPLDAVLIEDELEELHRYCQEVFGR-VSRFHR 6345
Score = 194 bits (493), Expect = 2e-48
Identities = 336/1735 (19%), Positives = 661/1735 (38%), Gaps = 199/1735 (11%)
Query: 3785 QDAL-EPLLSWLADTEELIANQKPPSAEYKV-VKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
QDAL + ++ + +E +A+ + KV ++AQI+ K+ + K DML +
Sbjct: 4740 QDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ-----KLVADMLLIQ 4794
Query: 3843 GGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ-------LEDILVLAKQFHE 3895
A SA++ + L++ E+ W E +++ +++ L+ +L ++F E
Sbjct: 4795 ----AYSAKI-----LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDE 4845
Query: 3896 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3955
+ L + L + V ++ ++I ++ ++ +I ++Q + G+ L
Sbjct: 4846 NYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQL 4905
Query: 3956 -SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLA 4014
+S++ P +G +++ + + +I R ALL LS + D ++ WL
Sbjct: 4906 VASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS----YNRDSDQLTKWLE 4961
Query: 4015 EVEDKLS-----SVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL--KQ 4067
+ L+ S+ V D + + ++E+ + I G LL K+
Sbjct: 4962 SSQHTLNYWKEQSLNVSQ-DLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKE 5020
Query: 4068 TTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE 4127
T + ++ L + ++ + L Q + + E+ W+ VE
Sbjct: 5021 T---DTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEH 5077
Query: 4128 ELATSGG-QSPTG-EQIPQFQQRQKELKKEVMEHRLVLDTVNE----VSRALLELVPWRA 4181
+ + SP+ Q+ Q+ KE + E+ + ++D VN+ +S +E +
Sbjct: 5078 QTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYER 5137
Query: 4182 REGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241
E + L + N Q+ V + +++ ++ ++ + E W+ + +L L
Sbjct: 5138 TEFAEHL-GEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTL 5196
Query: 4242 GP---------IRLEQDQTTAQLQVQKAFSIDIIRHK----------------DSMDELF 4276
+ L+ QL + K+ ++D ++ +DELF
Sbjct: 5197 QKPESVISVQKLLLDCQDIENQLAI-KSKALDELKQSYLTLESGAVPLLEDTASRIDELF 5255
Query: 4277 SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEEL 4336
RS + Q L+ +S++Q+++ L E ++ +FW E
Sbjct: 5256 QKRSSVL-----TQVNQLKTSMQSVLQEWKIYDQLYDE-------VNMMTIRFWYCMEHS 5303
Query: 4337 SPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP 4396
P + + E LR Q E ++ L++ + +KL ++ +LK L P
Sbjct: 5304 KPVV--------------LSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCP 5349
Query: 4397 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKI-------EPMLE 4449
E++EEK Q + Q+ + + + + + H + E +
Sbjct: 5350 SVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQ 5409
Query: 4450 TLENLS-SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508
L N+S S + ++P + I+E D +Q + EA + L Q
Sbjct: 5410 QLANISMSGNNLAEILPPALQDIKELQHD----------VQKTKEAFLQNSSVLDRLPQP 5459
Query: 4509 ADKD--LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
A+ + L + + + + +A E E + + + L+ ++
Sbjct: 5460 AESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRL-ESLKGLIMHEEE 5518
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
D +H E +P V A + + L+E +++ +D+
Sbjct: 5519 NLDRLHQQEKE--NPDSFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAV--------- 5565
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPP 4685
K++ MN W T ER +L Q + L W+ I+
Sbjct: 5566 --KTLQNMNRQWIRATATALERCSEL----QGIGLNEKFLYCCEKWIQLLEKIEEALKVD 5619
Query: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELK 4745
V L + +Q K + EV Q + Q +L E + I E ++L
Sbjct: 5620 VANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITE-FSKLT 5678
Query: 4746 HLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEV 4805
W+N + + R+ ++G + F ++E L +LT T LL A + G +
Sbjct: 5679 DRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSA---VKGQERFSLY 5735
Query: 4806 ELAKH-HVLKNDVLAHQ---ATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4861
+ H LKN + Q T +AG +LL ++ S+ R+ + W+ +
Sbjct: 5736 QTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDME 5795
Query: 4862 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4921
+ E +Q QST++ +I++ L +++Q + P LPE E L E
Sbjct: 5796 PQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQ--SEDP---LPEL-HEDLHNEKE 5849
Query: 4922 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ------KWHVVSSKME 4975
L +L+ ++ Q L + + M + D E + L EQ +W + ++
Sbjct: 5850 LIKELEQSLASWTQNLKELQTM---KADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVA 5906
Query: 4976 ERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE-----HK 5030
RK ++E+ LN F +E WL E +L T IEE K
Sbjct: 5907 IRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK---------VLQTADISIEEMIEKLQK 5957
Query: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
E+N + ++L Q G+QL S K I + L + RW+ + R + L
Sbjct: 5958 DCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKL 6017
Query: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN-DPDKIKLQLSKHKEFQKTL---- 5145
+ +Q + L WL ES L + D +I+ +L++ ++ Q+ +
Sbjct: 6018 KETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHS 6077
Query: 5146 GGKQPVY---DTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEE 5202
G + V+ D + A +T + + + +W +C S+ER+ K+EE
Sbjct: 6078 AGVESVFNICDVLLHDSDACANET----ECDSIQQTTRSLDRRWRNICAMSMERRMKIEE 6133
Query: 5203 ALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTV 5262
+F+D DWL E A + + FQ+++ +R +
Sbjct: 6134 TWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQL 6193
Query: 5263 QVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 5321
+++ + R L +R DT + +K + E + RWD + + + RL Q E F T
Sbjct: 6194 ELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGT 6253
Query: 5322 VHMLLEWLSEAEQTL----RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMG 5377
+L WL+E + L F + DD ++ L F +++ ++ + G
Sbjct: 6254 RESILVWLTEMDLQLTNVEHFSESDADD--KMRQL----NGFQQEITLNTNKIDQLIVFG 6307
Query: 5378 EVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLE 5432
E ++ P I+ + + +EV + +RL + L E E
Sbjct: 6308 EQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASE 6362
Score = 188 bits (478), Expect = 1e-46
Identities = 631/3394 (18%), Positives = 1314/3394 (38%), Gaps = 522/3394 (15%)
Query: 1781 KGNGGVNPEPFRATQNVFTRQLCLEHDEK-----LVSYLSLLRNIEMRTKQIQPLELNLA 1835
K N N + ++ QN+ E DEK L + L +L I+ + +Q + L +
Sbjct: 3124 KLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIK 3183
Query: 1836 ELQDLLCQAKVLERE-------LKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA 1888
+Q+ + + + +K +T + Q E S+ +V +L ++
Sbjct: 3184 HIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENS-----SEASDVETKL-----REF 3233
Query: 1889 KNLQKSLSSVSDTWNSRLLH-FQNAVEIEK--TKVLNQHTQLEGRLQDLRAWVGNKNLIL 1945
++LQ L++ D + L ++N ++ T+ + T LE + R VGN
Sbjct: 3234 EDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPE--- 3290
Query: 1946 NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQ 2005
+SL + L++ E+L+ +A IQ + SP+ Q
Sbjct: 3291 -----------ESLEMPLRKQEELESTVAH-----------IQDLTEKLGMISSPEAKLQ 3328
Query: 2006 MLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV---KTLQKQQNTCHQQLEDLC 2062
LQ + Q+++ + +A +A + Q+ E E + K +K + + L +
Sbjct: 3329 -------LQYTLQELVSKNSAMKEAFKA--QETEAERYLENYKCYRKMEEDIYTNLSKME 3379
Query: 2063 SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 2122
+ +GQ+ +L + ++ L L+++++ + +L + +++ + EN
Sbjct: 3380 TVLGQSMSSLP----LSYREALERLEQSKALVSNLIST-KEELMKLRQILRLLRLRCTEN 3434
Query: 2123 QTKLSPRELTALREK----LHQAKEQY---EALQEETRVAQKELEEA--VTSALQQETEK 2173
+ ++AL EK L AKE E L++E + +E+E + LQ+E +
Sbjct: 3435 DGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPE 3494
Query: 2174 SKAAKELAENKKKIDALLDWVTSVGSS--GGQLLTNL--PGMEQLSGASLEKGALDTTDG 2229
KE A ++ + LLD + G + QLL L + + GA++T
Sbjct: 3495 ISKTKEAATTEE-LSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPA 3553
Query: 2230 YMGV-------NQAPEKLDKQCEMMKA----RH---QELLSQQQNFILATQSAQ--AFLD 2273
+ + N+ +K+ K E+++ RH +E+++ + F T S Q AF D
Sbjct: 3554 FQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQNMAFQD 3613
Query: 2274 QHGHNLTPEEQQMLQQKLGEL-------------KEQYSTSLAQSEAELKQVQTLQDELQ 2320
+ EE Q + +K G+L E Y+ A+ E+++++ + +++
Sbjct: 3614 HPEKSEQFEELQSILKK-GKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKALEDID 3672
Query: 2321 KFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTIS 2380
+ + + S +++E ++ G + E + + ++++ D + S
Sbjct: 3673 EKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELDLWHS 3732
Query: 2381 GQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQ 2440
LD E ++P + + D L ++Y + + S LN + ++
Sbjct: 3733 KLNELDSEVQDIVEQDPGQAQEWM-DNLMIPFQQYQQVSQRAECRTSQLNKATVKMEEYS 3791
Query: 2441 NSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVA 2500
+ S +AW++ N LL++ D A+T Q+ E +E + + L +
Sbjct: 3792 DLLKSTEAWIE----NTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL--LHSIF 3845
Query: 2501 RDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
D+ ++ + TD + Q LS + + +++ Q Q + + + ++
Sbjct: 3846 MDLEDLS---------IIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIE 3896
Query: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEAT-REMVTRFMETAD 2619
+ +E+ + + LS + + ++K + I ++ T E+V+ +E
Sbjct: 3897 SEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRL 3956
Query: 2620 STTAAVLQGKLAEVSQRFEQLCLQQ---QEKESSLKKLLPQAEMFEHLSGKLQQFMENKS 2676
T +Q + + L + QE+ LK ++ Q ++ L+Q + N S
Sbjct: 3957 PQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYS 4016
Query: 2677 RMLASGNQ-PDQDITHFFQQIQELNLEMEDQQENLDTL----EHLVTELSSCGFALDLCQ 2731
+ + PDQ ++ +L E+E ++ + +L E L+ +L + L+L Q
Sbjct: 4017 AQFSLEHMSPDQA-----DKLPQLQGEIERMEKQILSLNQRKEDLLVDLKAT--VLNLHQ 4069
Query: 2732 HQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS 2791
H + Q + E + ++ + E + R +L E + E+S
Sbjct: 4070 HLKQEQ----EGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVE--ESS 4123
Query: 2792 MSAKELEKQIE-----------HLKSLLDDWASK--GTLVEEINCKGTSLENLIMEITAP 2838
+ + +++ E H K + +D AS GT+V+E K ++ +N + +I P
Sbjct: 4124 VKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTP 4183
Query: 2839 DS--------------QGKTGSILPSVGSSVGSVNG------------------YHTCK- 2865
DS Q + G+ P ++ S + H CK
Sbjct: 4184 DSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKT 4243
Query: 2866 DLTEIQCDMSDVNLKYE------KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919
+ E++ + N+ E + VL ++ QA+L +E HK A +L+ + +
Sbjct: 4244 QVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIE--HKVA-FLLETCKDQ 4300
Query: 2920 ---EEVLKSMDAMSSPTKTETVKAQAESNKAFLAE--LEQNSPKIQKVKEALAGLLVTYP 2974
+ +A + K +TVK E + L E E P I K + P
Sbjct: 4301 GLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKS--------SEP 4352
Query: 2975 NSQEA---ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEK 3031
QEA N +++ + R + + + +Q+ LE L+P + +K
Sbjct: 4353 EHQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLE---------------LKP-MEQK 4396
Query: 3032 ELMMGVLGPLSIDPNMLNAQKQQVQF------MLKEFEARRQQHEQLNEAAQGILTGPGD 3085
+ + + NA+K Q+ +E A Q N+ IL+ G
Sbjct: 4397 DFIKFI---------EFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDSILSPQGQ 4447
Query: 3086 ---------------VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 3130
+ L Q+ + S N + N R ++ +TQ ++
Sbjct: 4448 NGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKTYTTQLED 4507
Query: 3131 LLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL 3190
L Q+ S ++Q+ + EA ++ E+ L Q V+E E+
Sbjct: 4508 LRQEAS----------NLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEML----EM 4553
Query: 3191 SVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA----STQQFQQMFDELR 3246
L E ++ ET+AL L+ L +D+ L A+ +T + FD L+
Sbjct: 4554 PRLYREDGSGQQV--HYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQ 4611
Query: 3247 TWLDDKQ------SQQAK-----NCPISAKLERLQSQL-QENEEFQKSLNQHSG------ 3288
L+ Q S+ K N +++RL QL + Q+SLN+ SG
Sbjct: 4612 VCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQ 4671
Query: 3289 -----SYEVIVAEGESLLLSVPPGEEK----RTLQNQLVELKNHWEELSKKTADRQSRLK 3339
+Y V + ES + + E+ L ++ +L++ + + R + L
Sbjct: 4672 LQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELS 4731
Query: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMS--ELRVTLDPVQLESSLLRSKAMLNEVEKRRS 3397
+ ++ +V ++ K K++ L+ T V L++ + K ++
Sbjct: 4732 SPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLV--AD 4789
Query: 3398 LLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG-SLEEMTQRLREFQ 3456
+L I +A IL + + E ++ + + EE + G L+ + Q+ EF
Sbjct: 4790 MLLIQAYSAKILPSLLQNRETFWAEQVTEVK-----ILEEKSRQCGMKLQSLLQKWEEFD 4844
Query: 3457 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3516
E++ ++EK +E + L S + + E+L + Q ++ +
Sbjct: 4845 ENYASLEKDLE------ILISTLPSVSLVEETEERLVERISFYQQIKRNI---------- 4888
Query: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNS-GCVMMENKLEGI-GQFHCRVREMFSQ 3574
G ++L Q E KQ V S C +E ++ + Q+ +++ +
Sbjct: 4889 ------GGKHARL-------YQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHE 4935
Query: 3575 LADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKL----DIEASEAECRHMLEEE 3630
L L L + + RD+D L +E + LN L D++ + + E
Sbjct: 4936 LHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFS 4995
Query: 3631 GTLD-LLGLKRELEALNKQCGKLTERGKAR--------QEQLELTLGRVEDFYRKLKGLN 3681
+D LK + ++ Q L E A +++ + + ++ D KL L
Sbjct: 4996 KEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQ 5055
Query: 3682 DATTAAEEA--EALQWVVGTEVEIINQQLADF--------KMFQKEQVDPLQMKLQQ--V 3729
+ +A E + W+ E + ++ + QK + ++M +Q V
Sbjct: 5056 MEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIV 5115
Query: 3730 NGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
+ + Q L+Q + CDV+ ++ + E+N +W+ ++ + ++I L++ L
Sbjct: 5116 DFVNQSLLQLS--TCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESIT 5173
Query: 3783 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQA- 3841
+ ++ ++ L +WL EE + + P + V K + Q + +L KA ++ Q+
Sbjct: 5174 ESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSY 5233
Query: 3842 ---EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE 3898
E G + + A R ++ L + + +L++ + ++ +L K + + +
Sbjct: 5234 LTLESGAVPLLEDTASR------IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYD 5287
Query: 3899 PISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL 3958
++ + +S+PV ++ Q+ ++L+++ E+ + ++ L L
Sbjct: 5288 EVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL 5347
Query: 3959 TSPAEQGVLSEKIDSLQARYSE----IQDRCCRKAALLD--QALSNARLFGEDEVEVLNW 4012
P+ ++ EK + R+++ I D+ + +LL +A SNA GE +
Sbjct: 5348 -CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH--GEAAARLKQQ 5404
Query: 4013 LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
A+ + + + ++L D L ++ K+ Q L +
Sbjct: 5405 EAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESST 5464
Query: 4073 VLLIQEKLDGI-KTRYAD--ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL 4129
+L+ L + + Y + + V +++ L Q + + +S L G + EE L
Sbjct: 5465 HMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLES----LKGLIMHEEENL 5520
Query: 4130 ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL-------DTVNEVSRALLELVPWRAR 4182
+ Q++KE + H L L + +NEVS L
Sbjct: 5521 -------------DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKL------PLS 5561
Query: 4183 EGLDKLVSDANEQYKLVSDTIGQRVDEIDAA-------------IQRSQQYEQAADAELA 4229
+ K + + N Q+ + T +R E+ IQ ++ E+A ++A
Sbjct: 5562 DVAVKTLQNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVA 5621
Query: 4230 WVAE---TKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTC 4286
++K + + +QT A V ++ + ++ E + S++
Sbjct: 5622 NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRW 5681
Query: 4287 GEEQKTVLQEK--TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETR 4344
+ V Q K + L++Q++ + + L L++ + E S + +TR
Sbjct: 5682 QNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLLSAV-KGQERFS--LYQTR 5738
Query: 4345 ALIAQLPSPAIDHEQLRQ------QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398
+LI +L + I ++ R + E L + + ++ ++ K++ P+
Sbjct: 5739 SLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQL 5798
Query: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ-ITEFHDKIEPMLETLENLSSR 4457
EM+++ +Q + Q ++++++ L +QS + E H+ + E ++ L
Sbjct: 5799 AEMIKQ-FQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQS 5857
Query: 4458 L-----RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512
L + L + D R + + ++ L+ E L R+ E+L R
Sbjct: 5858 LASWTQNLKELQTMKADLTRHVLVE------DVMVLKEQIEHLHRQWEDLCLRVA----- 5906
Query: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
+ +EI+D+L+ V F E K EL W + + + T DI
Sbjct: 5907 IRKQEIEDRLNTWVVFNEKNK--------------ELCA--W--LVQMENKVLQTADI-- 5946
Query: 4573 DLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSID 4632
I+ I K Q + EE + E ++ +G LI A ++ E+ ++
Sbjct: 5947 -----SIEEMIEKLQKDC----MEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLN 5997
Query: 4633 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDL-- 4690
++N+ W++L R++KL++ Q + + WL +L PV D+
Sbjct: 5998 KINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESEL--SKPVVYDVCD 6055
Query: 4691 -NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA---TDETDRDIIREPLTELKH 4746
++ +L E ++ + ++ Q +E + + +++L + +ET+ D I++ L
Sbjct: 6056 DQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDR 6115
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W N+ R+ K+E +F WL E + E
Sbjct: 6116 RWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEE 6175
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
L + + + +E +NK L + D AS L+ + NQ W+++ ++
Sbjct: 6176 LKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTA 6235
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS 4900
++L+ Q + F E L+ LT M+ QL+
Sbjct: 6236 VLRRLRHFTNQREEFEGTRESILVWLTEMDLQLT 6269
Score = 172 bits (435), Expect = 1e-41
Identities = 668/3541 (18%), Positives = 1348/3541 (38%), Gaps = 525/3541 (14%)
Query: 1804 LEHDEKLV----SYLSL-----LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELK-- 1852
L H EKL+ YL L IE++ KQ L LQ+ Q K+ ++ LK
Sbjct: 2134 LSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHG-LQEKKAQLKIYKKFLKKA 2192
Query: 1853 -DLTTLVSQE-------LECVNQIIISQP-----QEVPAQLLKALEKDAKNLQ------- 1892
DLT+L+ + LEC S+ + + LL+ L+ +NL
Sbjct: 2193 QDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHD 2252
Query: 1893 ------KSLSSVSDTWNSRLLHF------QNAVE--IEKTKVLNQHTQLE-GRLQDLRAW 1937
L++ D ++ + F Q AVE ++K + L L+ G L+ + A
Sbjct: 2253 SYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILAL 2312
Query: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997
K++ N+ +I D + + +DL+ +A K +++ I +
Sbjct: 2313 A--KSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSI-------LKS 2363
Query: 1998 LSPQQNRQMLRLLNELQRSFQDILEQT--AAQVDALQGHLQQMEQEALVKTLQKQQNTCH 2055
+ + L +++ D+ E T +A V+ L+ + + A+ + KQ +
Sbjct: 2364 KRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNA 2423
Query: 2056 QQ----------LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDL-QDDIQNR 2104
Q+ + +L + + + L Q ++ + L+ ++ +K L Q + N+
Sbjct: 2424 QESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNK 2483
Query: 2105 ATSFATVVKDIEGFMEENQTKLSPRELTALREK------LHQAKEQYEALQEETRVAQKE 2158
+ A V+ +I G+ ++ L +T + K L +E A++ + +
Sbjct: 2484 TETGALVLHNI-GYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTD 2542
Query: 2159 LEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGAS 2218
E L T K K +A +K+ D+L ++ L ++ M++
Sbjct: 2543 KESLKVGPLDSVTYLDKIKKFIASIEKEKDSL----GNLKIKWENLSNHVTDMDK---KL 2595
Query: 2219 LEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHN 2278
LE G+ V Q +K Q + L+++ Q+ ++ Q Q L +
Sbjct: 2596 LESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQHLQLRLKS 2655
Query: 2279 LTPEEQQ------MLQQKLGELKEQYSTSLAQSEAELKQV------QTLQDELQKFLQDH 2326
PEE+ L L K +S Q+E ++K++ + L+D + +
Sbjct: 2656 --PEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQW 2713
Query: 2327 KEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFS-------EDVISHKGDLRFVTI 2379
+ E +E +++ ET+ G + +D++S +R +
Sbjct: 2714 ETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQ---IRKCKV 2770
Query: 2380 SGQKVLDMENSFK------EGKEPSEI---GNLVKDKLKDATERYTALHSKCTRLGSHLN 2430
+ +L + S + + K PS G+ + + L+D +Y L K T+ L
Sbjct: 2771 THDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLE 2830
Query: 2431 MLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ 2490
L + F Q +Q E + + + + A T + EL H
Sbjct: 2831 FKLEERSNFFAIIRKFQLMVQESETLI-------------IPRVETAAT---EAELKHHH 2874
Query: 2491 VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSI--LSHFQSLSY-----SLAERSSLLQ 2543
V +E QK ++ EI+ + H+QE T+ L+ F+ L +L R++ +Q
Sbjct: 2875 VTLEASQK---ELQEIDSGIST---HLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQ 2928
Query: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603
+ I + + E + E L+ ++ S+ + N +K++I K
Sbjct: 2929 RFIQNTCNEVEHKIKFCRQFHEKTSALQ-EEADSIQRNELLLNQEVNKGVKEEIYNLKDR 2987
Query: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663
L A + + + ++ L +++ +QL Q EKE L++ + Q + FE
Sbjct: 2988 LTAIKCCILQVLKLKKVFDYIGLNWDFSQL----DQLQTQVFEKEKELEEKIKQLDTFEE 3043
Query: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV----TE 2719
GK Q + S+M A Q +++ E+ L+ D L + E
Sbjct: 3044 EHGKYQALL---SKMRAIDLQ--------IKKMTEVVLKAPDSSPESRRLNAQILSQRIE 3092
Query: 2720 LSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLK 2779
+ C LC + N K F + K EK+ + +E KL + Q +
Sbjct: 3093 KAKC-----LCDEIIKKLNENKTFDDSFK-----EKEILQIKLNAEENDKLYKVLQNMVL 3142
Query: 2780 ETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD 2839
E + P E + K + ++E +L+ S+ IN + ++N
Sbjct: 3143 E----LSPKE--LDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQN--------- 3187
Query: 2840 SQGKTGSILPSVGSSVGSVNGYHTC-KDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898
+ + V + + S+ K E + SDV K + + + S+
Sbjct: 3188 EKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLR 3247
Query: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE--TVKAQAESNKAFLAELEQNS 2956
N + + ++ + + E + S++A+ P + + + E ELE
Sbjct: 3248 TNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTV 3307
Query: 2957 PKIQKVKEALAGLLVTYPNSQEAE-NWKKIQEELNSRWERATEVTVARQRQLEESASHLA 3015
IQ + E L + +S EA+ + +EL S+ E A++ + E +
Sbjct: 3308 AHIQDLTEKLGMI-----SSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYK 3362
Query: 3016 CFQAAESQLRPWLMEKELMMG-VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
C++ E + L + E ++G + L + + +Q + ++ + +++ +L +
Sbjct: 3363 CYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQ 3422
Query: 3075 AAQGI---LTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL 3131
+ + T + L K + ++ +KW+ L + + +++
Sbjct: 3423 ILRLLRLRCTENDGICL-----LKIVSALWEKWLSLLE--------------AAKEWEMW 3463
Query: 3132 LQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELS 3191
++L ++ + V + + ++ I + ++++L E S + KEA T +ELS
Sbjct: 3464 CEELKQEWKFVSEEIEREAIIL---DNLQEELPEIS-----------KTKEAAT-TEELS 3508
Query: 3192 VLIG--EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL 3249
L+ QY ++ K++L + L LQ + + + A+ + FQ++ T +
Sbjct: 3509 ELLDCLCQYGENVEKQQL-LLTLLLQRIRSI--QNVPESSGAVETVPAFQEI-----TSM 3560
Query: 3250 DDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE 3309
++ ++ + + E +Q+++QE F K ++++ +
Sbjct: 3561 KERCNKLLQK--VQKNKELVQTEIQERHSFTKE------------------IIALKNFFQ 3600
Query: 3310 KRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSEL 3369
+ T Q + ++H E S++ + QS LK K + E++ +E + K SE+
Sbjct: 3601 QTTTSFQNMAFQDH-PEKSEQFEELQSILK-------KGKLTFENI---MEKLRIKYSEM 3649
Query: 3370 RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQ 3429
T+ P ++ES + + L +++++ S + +S + + E +G+ + + + Q
Sbjct: 3650 -YTIVPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQ 3708
Query: 3430 NMDAV--TEELQAKT-GSLEEMTQRLREFQESFKNIEKKVEGAKHQ--------LEIFDA 3478
+ +E+Q K L+ +L E ++I ++ G + + +
Sbjct: 3709 KSKNIEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQ 3768
Query: 3479 LGSQA-CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537
+ +A C L K + E L + T L+ + D L H A Q
Sbjct: 3769 VSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQ 3828
Query: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
LE Q H + +F L DL +I +TD L
Sbjct: 3829 M------------------ALEDSEQKHNLLHSIFMDLEDL--------SIIFETDELTQ 3862
Query: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK 3657
I+++ N++ L+ I S + + M + D++ ++ E++++ K+ K+
Sbjct: 3863 SIQELS---NQVTALQQKIMESLPQIQRMAD-----DVVAIESEVKSMEKRVSKIKTILL 3914
Query: 3658 AR-------QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG--TEVEIINQQL 3708
++ +E L+ +E+ K + + + E Q + + NQ L
Sbjct: 3915 SKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLL 3974
Query: 3709 ADFKMFQ---KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNT--L 3763
D K+ + +EQ + L++ ++Q N D +++ L+ + +A+++ +
Sbjct: 3975 QDIKLLENVTQEQNELLKVVIKQTNEW----------DEEIENLKQILNNYSAQFSLEHM 4024
Query: 3764 NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQK 3823
+ A ++ QLQ G+ + + +LS E+L+ + K + + + QEQ+
Sbjct: 4025 SPDQADKLPQLQ------GEIERMEKQILSLNQRKEDLLVDLK--ATVLNLHQHLKQEQE 4076
Query: 3824 LLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3883
++R DR V EGG +A+R+ +L S +S AA ++++
Sbjct: 4077 GVER---DRLPAV--TSEEGG-------VAERDASERKLNRRGS-----MSYLAAVEEEV 4119
Query: 3884 EDILVLAKQFHETAEPISDFLSVTEK--KLANSEPVGTQTAKIQQQII---------RHK 3932
E+ V + E AEP S K K + + + I Q+ +
Sbjct: 4120 EESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQ 4179
Query: 3933 ALEEDIENHATDVHQAVKIGQSLSSLTSPAE---------QGVLSEKIDSLQARYSEIQD 3983
L D N +++ Q+ T P E QG L +++ + +E+
Sbjct: 4180 ILTPDSLNTEQGPECSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLH 4239
Query: 3984 RCCRKAALLDQALSNARLFGEDEV------EVLN--------WLAEVEDKLSSVFVKDFK 4029
C + A L+ L A + E E +VL L E+E K++ +
Sbjct: 4240 ACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKD 4299
Query: 4030 QDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYAD 4089
Q + H A E + + K V ++ Q +L++ E+ K
Sbjct: 4300 QGLGDNGATQHEA--EALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEA 4357
Query: 4090 ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQ 4149
+ + L ++ R ++ + ++ L+ +E++ + + PQ+ Q
Sbjct: 4358 LQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHD 4417
Query: 4150 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209
+ +E N+V ++L + + G DK +E + + Q V+
Sbjct: 4418 NDTTQESSASNQASSPENDVPDSILSP---QGQNG-DKWQYLHHELSSKIKLPLPQLVEP 4473
Query: 4210 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHK 4269
+ + E K L +R Q + LQ Q+ + + +
Sbjct: 4474 QVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLR----QEASNLQTQENMTEEAYINL 4529
Query: 4270 D-SMDELFSHRSEIFGTCGE--EQKTVLQEKTESLIQQYEAISLLNSERYARL--ERAQV 4324
D + ELF S+ + E E + +E YE ++L + Y L ++ +
Sbjct: 4530 DKKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDL 4589
Query: 4325 LVNQFW---------ETYEELSPWIEETR-ALIAQLPSPAIDHEQLRQQQEEMRQLRESI 4374
L W E ++ L +E T+ A + + S + R Q E+++L +
Sbjct: 4590 LKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQL 4649
Query: 4375 AEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEA---- 4430
+ K + + LN G+ V E+ QKA+ +++ + A DE
Sbjct: 4650 IKSKTSLQ---------QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLH 4700
Query: 4431 --VSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE------CISDNKSAT 4482
+ ++ + D ++ M L + L P + ++ D + + I K A
Sbjct: 4701 LPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAH 4760
Query: 4483 VELEK------LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED----- 4531
L++ LQ E K ++L+ + +AK + L FW +
Sbjct: 4761 GHLKQTKSKVALQAQIENHKVFFQKLVA-DMLLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
Query: 4532 --IKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVE 4589
++ ++ + +K +L+ E+F + A+L KD + ++ L S + ++ VE
Sbjct: 4820 KILEEKSRQCGMKLQSLLQKWEEFDENYASL---EKDLEILISTLPSVSLVEETEERLVE 4876
Query: 4590 AA---ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWK 4646
+ IK G H L G L+ PE+ I ++ W +LNK
Sbjct: 4877 RISFYQQIKRNIGGKHARLYQTLNEGKQLV---ASVSCPELEGQIAKLEEQWLSLNKKID 4933
Query: 4647 ERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP----VGTDLNTVKDQLNEMKE 4702
L +L+ ++ + Y + WL+++ L V DL+T++ +N E
Sbjct: 4934 HELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFE 4993
Query: 4703 FKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKL 4762
F EV ++ + G +L ETD +R L + + W L ++ Q KL
Sbjct: 4994 FSKEVDEKSSLKTAVISIGNQLLH--LKETDTATLRASLAQFEQKWTMLITQLPDIQEKL 5051
Query: 4763 EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--LAKHHVLKNDVLAH 4820
+ + A+ E++SW+ + E + + +V+ L KH + ++
Sbjct: 5052 HQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYK 5111
Query: 4821 QATVETVNKAGNELLESSAGDDASSLRSRLE------AMNQCWESVLQKTEEREQQLQST 4874
Q V+ VN++ LL+ S D S R E MN+ W V + Q L+
Sbjct: 5112 QWIVDFVNQS---LLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQL 5168
Query: 4875 LQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYN 4934
L+ ++I+ L E +L + + + LD ++ +QL K + +
Sbjct: 5169 LESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDC-QDIENQLAIKSKALD 5227
Query: 4935 QLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS 4994
+L K + L +SG +V LLE + ++R S L + L T Q+
Sbjct: 5228 EL--KQSYLTL---ESG-------AVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSV 5275
Query: 4995 LQEF---------INWLTLA-EQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044
LQE+ +N +T+ + + P L L T+ Q+E + +E +
Sbjct: 5276 LQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWE 5335
Query: 5045 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAW 5104
+L + +LK L +I+ + RW +V Q ++ D ++A+ + W
Sbjct: 5336 KLQEVIGKLKGLCPSV-AEIIEEKCQNTHKRWTQVNQ-------AIADQLQKAQSLLQLW 5387
Query: 5105 K 5105
K
Sbjct: 5388 K 5388
Score = 122 bits (305), Expect = 1e-26
Identities = 555/3237 (17%), Positives = 1235/3237 (38%), Gaps = 420/3237 (12%)
Query: 2447 QAWMQACEANVEKLLSDTVASDPGV--LQEQLATTKQLQEELAEHQ-------------- 2490
+AW+Q E +++ LS + V +QE++ K L + H
Sbjct: 396 EAWLQEVEELMDEDLSASQDHSQAVTLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHL 455
Query: 2491 --VPVEKLQKVARDIMEIEGEP----APDHRH---VQETTDSILSHFQ--SLSYSLAERS 2539
VP KL+++ R I I + H + V D + S ++ Y E
Sbjct: 456 PLVPPNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV 515
Query: 2540 SLLQK---AIAQSQSVQESLESLLQSIGEVEQNLEG------KQVSSLSSGVIQEALATN 2590
LL + + + L++ Q GE+ +NL G KQ + S V
Sbjct: 516 ELLLEDWHKFIEEKEFLARLDTSFQKCGEIYKNLAGECQNINKQYMMVKSDVCM------ 569
Query: 2591 MKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESS 2650
+++I KS+L+ ++E A + K E+ + + Q + ++
Sbjct: 570 --YRKNIYNVKSTLQKVLACWATYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHAT 627
Query: 2651 LKKL------LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEME 2704
L + + + +S +L++ + + R L S Q + ++ I++ +
Sbjct: 628 LNEAGNFLVEVSNDVVGSSISKELRR-LNKRWRKLVSKTQLEMNLP---LMIKKQDQPTF 683
Query: 2705 DQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQL 2764
D N+ + E T S +++L ++ + QN++ +K KE E+ +
Sbjct: 684 DNSGNILSKEEKATVEFSTDMSVELPENYN--QNIKAG----EKHEKENEEFTGQLKVAK 737
Query: 2765 DEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCK 2824
D KL+ + W E + + + S +E K + S+ D+ ++ + +++ +
Sbjct: 738 D-VEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQ 796
Query: 2825 GTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKL 2884
S + + Q K V +V V K+LT++ D+ D+ LK E+
Sbjct: 797 NISSQESFQHVLTTGLQAKIQEAKEKVQINV--VKLIAALKNLTDVSPDL-DIRLKMEES 853
Query: 2885 GGVLHERQESLQAILNRMEEV------HKEANSVLQWLESKEEVLKSMDAMSSPTKTETV 2938
L Q +L + E HKEA ++ +S + LK+++ + + +
Sbjct: 854 QKELESYMMRAQQLLGQRESPGELISKHKEA-LIISNTKSLAKYLKAVEELKNNVTEDIK 912
Query: 2939 KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE 2998
+ E ++ A+ E ++ + L + + ++N K+++++N +
Sbjct: 913 MSLEEKSRDVCAKWESLHHELSLYVQQLK---IDIEKGKLSDNILKLEKQINKE-----K 964
Query: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 3058
+ R R H ACF L + M VL L + +Q Q+V+ +
Sbjct: 965 KLIRRGRTKGLIKEHEACFSEEGC-----LYQLNHHMEVLRELCEELPSQKSQ-QEVKRL 1018
Query: 3059 LKEFEARRQQ--------HEQLNEAAQGILTGPGDVSLSTSQ----------VQKELQSI 3100
LK++E + ++ H L A G G ++ S ++ + + Q
Sbjct: 1019 LKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
Query: 3101 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ-DLSEKVRAVGQRLSVQSAISTQPEAV 3159
+K +E T K + S +++ Q + +++ D S + ++ +R I +
Sbjct: 1079 TEKAMEPTMKFSLAS------VLRPLQEESIMEKDYSASINSLLERYDTYRDI-LEHHLQ 1131
Query: 3160 KQQLEETSEIRSDLEQ----LDHEVKEAQTLCDELSVLIGE-QYLKDELKKRLETVALPL 3214
+ TS+ S+ ++ L ++ + Q + +E E + + +L+ + + P
Sbjct: 1132 NNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPF 1191
Query: 3215 QGLE-DLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ- 3272
E D +R LQ L + + + + LR L +++ C L ++ Q
Sbjct: 1192 VIKERDTLKERERELQMTLNT--RMESLETALRLVLPVEKASLLL-CGSDLPLHKMAIQG 1248
Query: 3273 ---------LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNH 3323
Q Q S+ + + G +L + P + +QN +++ K
Sbjct: 1249 FHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFD-LHAMQNIILKYKTQ 1307
Query: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
+E ++ + +Q++ ED + +ED A + +++ +PV S+
Sbjct: 1308 FEGMNHR-----------VQRS-------EDTLKALEDFLASLRTAKLSAEPVTDLSASD 1349
Query: 3384 RSKAMLNE--VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 3441
A N V+ + + ++ A L + + +D + G + + + + + K
Sbjct: 1350 TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK 1409
Query: 3442 T------GSLEEMTQRLREFQES-FKNIE--KKVEGAKHQLEIFDALGSQACSNKNLEK- 3491
G EE T+ + + FKN E K ++ + Q+ + K+ +K
Sbjct: 1410 LSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
Query: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551
L +VL E + +L+ L DG + + + Q + + K V
Sbjct: 1470 LIRLDKVLDEYEEEKRHLQEMANSLPH-FKDGREKT-VNQQCQNTVVLWENTKALVTECL 1527
Query: 3552 VMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV 3611
LE + Q+ + + + L ++ + + A ++L+ +I ++ + + +
Sbjct: 1528 EQCGRVLELLKQYQ-NFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNE 1586
Query: 3612 LKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3668
++ C+++ L + T + ++E + + + E+ + E L L
Sbjct: 1587 HLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALA 1646
Query: 3669 RVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3728
+ + +++ T A + L + + E + ++L +++ ++ +
Sbjct: 1647 LWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL----QVHEQKTSEFSRRVAE 1702
Query: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC-----GK 3783
+ Q L+QS+ ++Q +E + LNK + E+ H +
Sbjct: 1703 I----QFLLQSSEIPLELQVMESSI---------LNKMEHVQKCLTGESNCHALSGSTAE 1749
Query: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
++ L+ + + TE L+ P + K + +Q++LQ+ K ++ +L+ +
Sbjct: 1750 LREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQ-----KHSMILLENQI 1804
Query: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
G + T +L L+ ++ + ++ L+D +K ++ + +D+
Sbjct: 1805 GCL------------TPELSELKKQYESVSDLFNTKKSVLQDHF--SKLLNDQCKNFNDW 1850
Query: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3963
S + L ++T K +Q ++ + +E + + Q + + + A
Sbjct: 1851 FSNIKVNLKECFE-SSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAH 1909
Query: 3964 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV 4023
L + + +++ C +A L+ +L +D + WL E+K +
Sbjct: 1910 VKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM 1969
Query: 4024 FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083
K ++ LA E ++ ++K ++ E + ++ +
Sbjct: 1970 EEPGEKTELF----CQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTL 2025
Query: 4084 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELA---TSGGQSPTGE 4140
+ ++I K L T +Q+ F ++ W++E++E L +S G+ P E
Sbjct: 2026 LRQLSEIE-EEDKLLPTEDQS------FNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
Query: 4141 QIPQFQQRQKELKKEVMEHRLVLDTVN---EVSRALLELVPWRAREGLDKLVSDANEQYK 4197
+I Q+ KE+ E ++T+ E S A L + K ++D + Q+
Sbjct: 2079 RI----QKIKEIILLKPEGDARIETIMKQAESSEAPL----------VQKTLTDISNQWD 2124
Query: 4198 LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQV 4257
+ + + ++Y Q+ + + E K+K A ++ + AQL++
Sbjct: 2125 NTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKI 2184
Query: 4258 QKAFSIDIIRHKDSMDELFSHRSEIFG-----TCGEEQKTVLQEKTESLIQQYEAISLLN 4312
K F + EL S + + + EE ++ ESL+QQ + S+ N
Sbjct: 2185 YKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQD-SVQN 2243
Query: 4313 SERYARLERA-QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR 4371
+ + R + QV V T + S + ++ P +D + ++ +++++L
Sbjct: 2244 LDGHVREHDSYQVCVTDLNTTLDNFS------KEFVSFSDKP-VDQIAVEEKLQKLQELE 2296
Query: 4372 ESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE--------KYQKAENMYAQIKEEVRQR 4423
++ + K+L + +K+ G+ + + K + EN A K+E+
Sbjct: 2297 NRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEME-- 2354
Query: 4424 ALALDEAVSQSTQITEFHDKIE-PMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSAT 4482
++ +S + TE K P E + +S ++ A V+K+ E NK +
Sbjct: 2355 --CCLNSILKSKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSA 2410
Query: 4483 VELEKLQP----SFEALKRRGEEL-IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE 4537
VE+ + + E++K +E + Q +L ++L+++ + ++A+
Sbjct: 2411 VEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAK-- 2468
Query: 4538 EREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES-------PGIDPSIIKQQVEA 4590
+ IK L+ E K L Q + + L++ +++ E
Sbjct: 2469 KAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEY 2528
Query: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEK--PEVRKSIDEMNNA---WENLNKTW 4645
++ L + E +++ D + + +K + K D + N WENL+
Sbjct: 2529 LAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHV 2588
Query: 4646 KERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV 4705
+ +KL ++ +++ ++ ++ + K + V D T +N++++ ++
Sbjct: 2589 TDMDKKLLESQIKQLEHG------WEQVEQQIQKKYSQQVVEYDEFTTL--MNKVQDTEI 2640
Query: 4706 EVYQQQIEMEK------------------------------LNHQGELMLKKATDETDRD 4735
+ QQQ ++ L Q EL +K+ E ++
Sbjct: 2641 SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
Query: 4736 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4795
+ + + LK WE L +++++ ++ ++E + W + L+ P
Sbjct: 2701 NLEDGINNLKKQWETLEPLHLEAENQIKKC-----DIRNKMKETILWAKNLLGELNPSIP 2755
Query: 4796 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855
+ D + ++ K V + +LA Q +VE++ + + + S + S L + LE +
Sbjct: 2756 LLPDDILSQIRKCK--VTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRN 2813
Query: 4856 CWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQ 4915
++ ++ K+ +R QQL+ L++ F + I F L + E+ + T T E
Sbjct: 2814 QYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAA---TEAEL 2870
Query: 4916 LDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975
H+ L + K +E DSG + ++ + E+ +E
Sbjct: 2871 KHHHVTLEASQKELQEI----------------DSGISTHLQELTNIYEELNVFERLFLE 2914
Query: 4976 ERKSKLEEALNLATEF-QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFAN 5034
++ L+ N F QN+ E + + Q S L I+ +++ N
Sbjct: 2915 DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSA----LQEEADSIQRNELLLN 2970
Query: 5035 -EVNAH-RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE-----KVVQRSIERG 5087
EVN +++I L +K + V+ +K + + W+ ++ + E+
Sbjct: 2971 QEVNKGVKEEIYNLKDRLTAIKCCILQ--VLKLKKVFDYIGLNWDFSQLDQLQTQVFEKE 3028
Query: 5088 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGG 5147
+ L++ K+ F E K L + I LQ+ K E
Sbjct: 3029 KELEEKIKQLDTFEEEHGKYQALLSKMRA--------------IDLQIKKMTEVVLKAPD 3074
Query: 5148 KQPV---YDTTIRTGRALKEKTLLPEDSQKLDN---FLGEVRDKWDTVCGKSVERQHKLE 5201
P + I + R K K L E +KL+ F ++K + E KL
Sbjct: 3075 SSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLY 3134
Query: 5202 EAL-----------LFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV 5250
+ L L D L+ + L +++ QL + ++ ++ + N D +
Sbjct: 3135 KVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEA 3194
Query: 5251 FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR--- 5307
FQ+++ +++ + ++ ENS + + V+ +L+E D +L+ S R
Sbjct: 3195 FQEQVWAEMCSIKAVTAIEKQREENS-SEASDVETKLREFE---DLQMQLNTSIDLRTNV 3250
Query: 5308 LEQALKQAEVFRDTVHMLLEWLSEAEQ-TLRFRGALPDDTEALQSLIDTHKEFMKKVEEK 5366
L A + +++ V +E ++ E + +R + + E+L+ ++K EE
Sbjct: 3251 LNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP-------LRKQEEL 3303
Query: 5367 RVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVA 5426
V + E + + P+ +++ + + ++ + K + E L
Sbjct: 3304 ESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKC 3363
Query: 5427 NAELLEELLAWIQWAETTLIQRDQEPIP-------QNIDRVKALIAEHQTFMEEMTR 5476
++ E++ + ET L Q +P + +++ KAL++ + EE+ +
Sbjct: 3364 YRKMEEDIYTNLSKMETVLGQ-SMSSLPLSYREALERLEQSKALVSNLISTKEELMK 3419
Score = 118 bits (296), Expect = 2e-25
Identities = 580/3196 (18%), Positives = 1207/3196 (37%), Gaps = 488/3196 (15%)
Query: 2111 VVKDIEG-FMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQ 2169
++K+ E F EE + LRE + Q Q+E + K+ E+ + L+
Sbjct: 975 LIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKS--QQEVKRLLKDYEQKIERLLKC 1032
Query: 2170 ETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG 2229
+E + A K + +T+ + GG + P + + S EK T
Sbjct: 1033 ASEIHMTLQPTAGGTSKNEGT---ITTSENRGGDPHSEAPFAKSDNQPSTEKAMEPTMKF 1089
Query: 2230 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE------- 2282
+ P L ++ M K + S + + + L + +T +
Sbjct: 1090 SLASVLRP--LQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDR 1147
Query: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE-----FESWLERSE 2337
LQ KL +L+ + +++A K+ + + +L+ + D K+ L+ E
Sbjct: 1148 SSSCLQAKLTDLQVIKN----ETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERE 1203
Query: 2338 KELE-NMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE 2396
+EL+ ++ S ET L+ S + L + I G ++D + ++ +
Sbjct: 1204 RELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRN 1263
Query: 2397 PS--------------EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNS 2442
E GN V +L LH+ + + G H+ Q S
Sbjct: 1264 IQDSIAKQIEICNRLEEPGNFVLKELHPFD-----LHAMQNIILKYKTQFEGMNHRVQRS 1318
Query: 2443 ADSLQAW------MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKL 2496
D+L+A ++ + + E + +D ASD V QE T K + E+ + + L
Sbjct: 1319 EDTLKALEDFLASLRTAKLSAEPV-TDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHL 1377
Query: 2497 QKVARDI-MEIEGEPAPDHRHVQETTDSIL-----SHFQSLSYSLAERSSLLQKAIAQSQ 2550
K + + M + D + D+ +H + E + LL+ I ++
Sbjct: 1378 DKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNN 1437
Query: 2551 SVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM 2610
+ ++++ + I ++ L+ V ++ +++L K+ + +K L+
Sbjct: 1438 ELLKNIQDVQSQISKI--GLKDPTVPAVKHR--KKSLIRLDKVLDEYEEEKRHLQEMANS 1493
Query: 2611 VTRFMETADST-------TAAVLQGKLAEVSQRFEQ------LCLQQQEKESSLKKLLPQ 2657
+ F + + T T + + A V++ EQ L Q Q +S L L+ +
Sbjct: 1494 LPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQK 1553
Query: 2658 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQ---------- 2707
E L EN + +A ++ + + ++N ++ Q
Sbjct: 1554 EESVISLQASYMG-KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFE 1612
Query: 2708 -------------ENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTE--LQKTVKE 2752
LD E + G AL L ++N+ ++TE LQK
Sbjct: 1613 EPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELH 1672
Query: 2753 R--EKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQI----EHLKS 2806
+ E+D +E+L + F + + E + + +E + + +E I EH++
Sbjct: 1673 QLTEEDRERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQK 1732
Query: 2807 LLDDWA-------SKGTLVEEINCKGTSL---ENLIMEITAPDSQGKTGSILPSVGSSVG 2856
L + S L E+++ T + E+L+ ++ DS + + L + +
Sbjct: 1733 CLTGESNCHALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSL-EIFTKLEEIQQQI- 1790
Query: 2857 SVNGYHTCKDL-TEIQC---DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
+ H+ L +I C ++S++ +YE + + + ++ LQ +++ ++ + +
Sbjct: 1791 -LQQKHSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKL--LNDQCKNF 1847
Query: 2913 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2972
W + + LK S K+ K Q S+ FL LE + KI++V L +
Sbjct: 1848 NDWFSNIKVNLKECFESSETKKSVEQKLQKLSD--FLT-LEGRNSKIKQVDSVLKHVKKH 1904
Query: 2973 YPNSQEAE--NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM- 3029
P + E +W QE E+ + AR ++LE+S L Q LR WL
Sbjct: 1905 LPKAHVKELISWLVGQE---FELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTN 1961
Query: 3030 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE---QLNEAAQGI-LTGPGD 3085
++E G+ P ++ + + +R+Q E QLN + + T +
Sbjct: 1962 QEEKWKGMEEP-----------GEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEE 2010
Query: 3086 VSLSTSQVQKELQSINQKW--VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ + + + Q++ ++ +E DKL Q + +L D+ ++ +
Sbjct: 2011 IIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQ---------SFNDLAHDVIHWIKEIK 2061
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE- 3202
+ L V + +SE + LE+ ++KE L E I E +K
Sbjct: 2062 ESLMVLN---------------SSEGKMPLEERIQKIKEIILLKPEGDARI-ETIMKQAE 2105
Query: 3203 ------LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQ 3256
++K L ++ LA+ ++ + L +++ Q ++LR L + + +Q
Sbjct: 2106 SSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQ 2165
Query: 3257 AKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQ 3316
+ L+ ++QL+ ++F K + + + ++G LL + +
Sbjct: 2166 EAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECT---KNPSFSEEP 2222
Query: 3317 LVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED-CKAKMSELRVTLDP 3375
+E+K+ E L ++ D L +++ YQ V DL +++ K +S +D
Sbjct: 2223 WLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQ 2282
Query: 3376 VQLESSLLRSKAMLNEVEKRRSLLE-----ILNSAADILINSSEADEDGIRDEKAGINQN 3430
+ +E L + L E+E R SL + IL A + N+S + I+D+
Sbjct: 2283 IAVEEKLQK----LQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDD------- 2331
Query: 3431 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE 3490
++ Q K++E ++ AK ++E C N L+
Sbjct: 2332 ---------------------IKSLQCKQKDLENRLASAKQEME--------CCLNSILK 2362
Query: 3491 KLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV---KQRV 3547
R+ ++ + P + + T + E + + +L E+ + +E+ KQ
Sbjct: 2363 SKRSTEKKGKFTLPGRE--KQATSDVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLS 2420
Query: 3548 NSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLN 3607
+ M+N + +V E+ +Q +LD L Q+E++
Sbjct: 2421 LNAQESMKNT-----EDERKVNELQNQPLELDTML------------RNEQLEEIEKLYT 2463
Query: 3608 KIHVLKLDIEASE-AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELT 3666
++ K I+ E EC + E G L L + + L+ L K ++ Q +
Sbjct: 2464 QLEAKKAAIKPLEQTECLNK-TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCV- 2521
Query: 3667 LGRVEDFYRKLKGLNDATTA-AEEAEALQWVVG-----TEVEIINQQLADFKMFQKEQVD 3720
+ DF L + + A + E+L+ VG T ++ I + +A + +K+ +
Sbjct: 2522 ---LRDFQEYLAAVESSMKALLTDKESLK--VGPLDSVTYLDKIKKFIASIEK-EKDSLG 2575
Query: 3721 PLQMKLQ----QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQE 3776
L++K + V + + L++S ++ LEH E++ + + KK +Q++ + E
Sbjct: 2576 NLKIKWENLSNHVTDMDKKLLES-----QIKQLEHGWEQVEQQ---IQKKYSQQVVEYDE 2627
Query: 3777 ALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATV 3836
K QD +S + L K P +A Q L L K
Sbjct: 2628 FTTLMNKVQDT---EISLQQQQQHLQLRLKSPEE-----RAGNQSMIALTTDLQATKHGF 2679
Query: 3837 DMLQAEGGRIAQSAELADREK--ITGQLESLESRWTEL----------LSKAAARQKQLE 3884
+L+ + + ++EK + + +L+ +W L + K R K E
Sbjct: 2680 SVLKGQ-AELQMKRIWGEKEKKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKE 2738
Query: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944
IL AK P L + + +Q K + A ++ +E+ A +
Sbjct: 2739 TIL-WAKNLLGELNPSIPLL---------PDDILSQIRKCKVTHDGILARQQSVESLAEE 2788
Query: 3945 VHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGE 4004
V V SLT+ E L+ ++ L+ +Y + + +++ L+ L F
Sbjct: 2789 VKDKV------PSLTT-YEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFA 2841
Query: 4005 DEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL 4064
+ + E E + + L H A +E+ + ++ +
Sbjct: 2842 IIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNI 2901
Query: 4065 LKQTTGEEVLLIQEKLDGIKTR----YADITVTSSKALRTLEQARQLATKFQSTYEELTG 4120
++ E L ++++L +K R I T ++ ++ RQ K + EE
Sbjct: 2902 YEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADS 2961
Query: 4121 WLREVEEELATSGGQSPTGEQIPQFQQRQKELK---KEVMEHRLVLDTVNEVSRALLELV 4177
R E L E+I + R +K +V++ + V D + +
Sbjct: 2962 IQR--NELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIG---------L 3010
Query: 4178 PWRAREGLDKLVSDANEQYKLVSDTIGQ--RVDEIDAAIQRSQQYEQAADAELAWVAETK 4235
W + LD+L + E+ K + + I Q +E Q +A D ++ + E
Sbjct: 3011 NWDFSQ-LDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVV 3069
Query: 4236 RKLMALGP--IRLEQDQTTAQLQVQKAFSIDIIR---HKDSMDELFSHRSEIFGTCGEEQ 4290
K P RL + +++ K +II+ + D+ F + + E+
Sbjct: 3070 LKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEE 3129
Query: 4291 KTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQL 4350
L + ++++ + L +LE + ++NQ + +QL
Sbjct: 3130 NDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQ-----------------IKSQL 3172
Query: 4351 PSPA---IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ 4407
P ++ + ++ +++ +E + I + I Q +E N E VE K +
Sbjct: 3173 QQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQ-REENSSEASDVETKLR 3231
Query: 4408 KAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAE 4467
+ E++ Q+ + R L++A +T + + + +E++ +L + +IP
Sbjct: 3232 EFEDLQMQLNTSIDLRTNVLNDAYE---NLTRYKEAVTRAVESITSLEA-----IIIPYR 3283
Query: 4468 VDKIRECISDNKSATVEL-----EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKL 4522
VD N ++E+ E+L+ + ++ E+L S K +Q+ +
Sbjct: 3284 VD------VGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELV 3337
Query: 4523 DQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS 4582
+ E KA+ E E ++L+ + K D+ L+ ++ + + S +
Sbjct: 3338 SKNSAMKEAFKAQETEAE-RYLENYKCYRKMEEDIYTNLSKMETV--LGQSMSSLPLSYR 3394
Query: 4583 IIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLN 4642
+++E ++ + EEL +R + L C E + + K + + W +L
Sbjct: 3395 EALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLL 3454
Query: 4643 KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKE 4702
+ KE E+ Q + ++ LDN ++++L E+ +
Sbjct: 3455 EAAKEWEMWCEELKQEWKFVSEEIEREAIILDN-----------------LQEELPEISK 3497
Query: 4703 FKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKL 4762
K + E+L+ + + + + + ++ L + +N+ E
Sbjct: 3498 TK-----EAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPES-------- 3544
Query: 4763 EGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA--- 4819
GA+ + FQ E+ S +LL + + + ++++ E+ + H +++A
Sbjct: 3545 SGAVETVPAFQ----EITSMKERCNKLL---QKVQKNKELVQTEIQERHSFTKEIIALKN 3597
Query: 4820 --HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4877
Q T N A + E S + L+S L+ +E++++K + ++ T+
Sbjct: 3598 FFQQTTTSFQNMAFQDHPEKS--EQFEELQSILKKGKLTFENIMEKLRIKYSEMY-TIVP 3654
Query: 4878 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT------HMELYSQLKAK-- 4929
A+ S++E+ L ++ ++S R +++ ++E Q K+K
Sbjct: 3655 AE-IESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNI 3713
Query: 4930 ---EETYNQLLDK------------GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKM 4974
+E ++ D+ + + D G + ++ + Q++ VS +
Sbjct: 3714 EKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRA 3773
Query: 4975 EERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL-NIASPPSL-----ILNTVLSQIEE 5028
E R S+L +A E+ + L+ W+ L N A SL +TV +E+
Sbjct: 3774 ECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALED 3833
Query: 5029 --------HKVFAN----EVNAHRDQIIE-LDQTGNQLKFLSQK------------QDVV 5063
H +F + + D++ + + + NQ+ L QK DVV
Sbjct: 3834 SEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVV 3893
Query: 5064 LIKNLLVSVQSRWEKV 5079
I++ + S++ R K+
Sbjct: 3894 AIESEVKSMEKRVSKI 3909
Score = 115 bits (288), Expect = 1e-24
Identities = 496/2765 (17%), Positives = 1049/2765 (37%), Gaps = 322/2765 (11%)
Query: 1879 QLLKALEKDAKNLQKSLSSVSDTWNSRLL----HFQNAVEI-EKTKVL-NQHTQLEGRLQ 1932
++L E++ ++LQ+ +S+ + R QN V + E TK L + + GR+
Sbjct: 1475 KVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGRVL 1534
Query: 1933 DLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKA-------------Q 1979
+L N IL + E V SL E+LK+ +AE + +
Sbjct: 1535 ELLKQYQNFKSILTTLIQKEE-SVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDK 1593
Query: 1980 LDALAFDIQFFISEHAQDLSPQQNRQMLRL------LNELQRSFQDILEQTAAQVDALQG 2033
++ + ++QF++++ P ++ + +NE + + L + A D L
Sbjct: 1594 INQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLF- 1652
Query: 2034 HLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQ--------QDLS 2085
+L+ + E K LQK + HQ E+ + + L H+ +T++ Q L
Sbjct: 1653 NLKNVIDEWTEKALQKME--LHQLTEEDRE---RLKEELQVHEQKTSEFSRRVAEIQFLL 1707
Query: 2086 ALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQY 2145
+ +L+ ++ I N+ V K + G E N LS LRE L QAK Q
Sbjct: 1708 QSSEIPLELQVMESSILNKMEH---VQKCLTG--ESNCHALSG-STAELREDLDQAKTQI 1761
Query: 2146 EALQEETRVAQK--------ELEEAVTSALQQ-------ETEKSKAAKELAENKKKIDAL 2190
+ + +LEE LQQ E + EL+E KK+ +++
Sbjct: 1762 GMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESV 1821
Query: 2191 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 2250
D + S + L L + D + + ++ + E K+
Sbjct: 1822 SDLFNTKKSVLQDHFSKL----------LNDQCKNFNDWFSNIKVNLKECFESSETKKSV 1871
Query: 2251 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK 2310
Q+L Q+ + L + + + Q L ++ + + + EL + L E EL+
Sbjct: 1872 EQKL--QKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKEL----ISWLVGQEFELE 1925
Query: 2311 QVQT--------LQDELQKFLQ---DHKEFESWLERSEKELENMHKGGSSPETLPSLLKR 2359
++++ L+D LQ+ L+ DH+ WL E++ + M + G E L R
Sbjct: 1926 KMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALAR 1985
Query: 2360 QGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDAT---ERYT 2416
+ E V + NS KE E ++ + +AT +RY
Sbjct: 1986 KREQFE-----------------SVAQLNNSLKEYGFTEE-----EEIIMEATCLMDRYQ 2023
Query: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
L + + + +L + F + A + W++ + ++ +L+ + P L+E++
Sbjct: 2024 TLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESL-MVLNSSEGKMP--LEERI 2080
Query: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
K++ E +E + K A E AP VQ+T I + + + + +
Sbjct: 2081 QKIKEIILLKPEGDARIETIMKQA------ESSEAP---LVQKTLTDISNQWDNTLHLAS 2131
Query: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
S +K + + + +S E L + E+++ E +L G +QE A K+
Sbjct: 2132 TYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG--FALQHG-LQEKKAQLKIYKKF 2188
Query: 2597 IARQKSSLEATREMVTRFMETADST-TAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2655
+ + + +E+ ++ + T + + E+ E L Q Q+ +L +
Sbjct: 2189 LKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHV 2248
Query: 2656 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQD---ITHFFQQIQELNLEMEDQQENLDT 2712
+ + ++ L ++N S+ S + D + Q++QEL + Q L
Sbjct: 2249 REHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKK 2308
Query: 2713 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR 2772
+ L + ++ +D +++L+ +L+ + +++ C L+ K R
Sbjct: 2309 ILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECC---LNSILKSKR 2365
Query: 2773 TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW-ASKGTLVEEINCKGTSLENL 2831
+ +K K T TS +E ++ ++ L +DW +K + VE K SL N
Sbjct: 2366 STEKKGKFTLPGREKQATS-DVQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSL-NA 2423
Query: 2832 IMEITAPDSQGKTGSILPSV--------GSSVGSVNGYHT--------CKDLTEIQC--D 2873
+ + + K + + + +T K L + +C
Sbjct: 2424 QESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNK 2483
Query: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
L +G LQA++ + + + + E V SM A+ T
Sbjct: 2484 TETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYCVLRDFQEYLAAVESSMKALL--T 2541
Query: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW 2993
E++K + +L ++++ I+K K++L L + W+ + +
Sbjct: 2542 DKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKI---------KWENLSNHVTDMD 2592
Query: 2994 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 3053
++ E + +QLE + Q + + ++E + ++ + L Q+Q
Sbjct: 2593 KKLLESQI---KQLEHGWEQVE--QQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQQ 2647
Query: 3054 QVQFMLKEFEARRQQHE--------QLNEAAQGILTGPGDVSLSTSQVQKE-------LQ 3098
+Q LK E R Q + +L G ++ + +KE +
Sbjct: 2648 HLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKKNLEDGIN 2707
Query: 3099 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEA 3158
++ ++W L +QI + +++ + +L A + +I P+
Sbjct: 2708 NLKKQWETLEPLHLEAENQIKKCDIRNKMKETILW-------AKNLLGELNPSIPLLPDD 2760
Query: 3159 VKQQLEETSEIRSDLEQLDHEVKE-AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217
+ Q+ + + V+ A+ + D++ L Y +L LE + Q L
Sbjct: 2761 ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSL--TTYEGSDLNNTLEDLRNQYQML 2818
Query: 3218 EDLAADRINRLQAAL-------ASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
+ R +L+ L A ++FQ M E T + + A + L+
Sbjct: 2819 VLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLE 2878
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
+ +E +E ++ H I E L+V E+ L++QL LK
Sbjct: 2879 ASQKELQEIDSGISTHLQELTNIYEE-----LNV---FERLFLEDQLKNLK--------- 2921
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLR---SKA 3387
R +R++ +Q VE + + K S L+ D +Q LL +K
Sbjct: 2922 --IRTNRIQRFIQNTCN---EVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKG 2976
Query: 3388 MLNEVEKRRSLLEILNSA-ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLE 3446
+ E+ + L + +L D G+ + + ++Q V E K LE
Sbjct: 2977 VKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFE----KEKELE 3032
Query: 3447 EMTQRLREFQE---SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALE 3503
E ++L F+E ++ + K+ Q++ + +A + + Q + Q +E
Sbjct: 3033 EKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIE 3092
Query: 3504 PQVDYLRNFTQGLVEDAP-DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG 3562
+ L E+ D S + + Q ++ +E ++ + + + +++E + +
Sbjct: 3093 KAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQN--MVLELSPKELD 3150
Query: 3563 QFHC--RVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
+ +C ++ L + +L I + +Q++ ++ F ++ I+A
Sbjct: 3151 EKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVT 3210
Query: 3621 AECRHMLEEEGTLDLLGLK-RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679
A + E + K RE E L Q ++L + D Y L
Sbjct: 3211 AIEKQREENSSEASDVETKLREFEDLQMQL----------NTSIDLRTNVLNDAYENLTR 3260
Query: 3680 LNDATTAAEEA----EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3735
+A T A E+ EA+ ++ V++ N + + +K+ + L+ + + L +
Sbjct: 3261 YKEAVTRAVESITSLEAI--IIPYRVDVGNPEESLEMPLRKQ--EELESTVAHIQDLTEK 3316
Query: 3736 LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWL 3795
L + + +Q L++ ++E+ ++ + + + + + + L + ++ E + + L
Sbjct: 3317 LGMISSPEAKLQ-LQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNL 3375
Query: 3796 ADTEELIA-NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELAD 3854
+ E ++ + Y+ ++++ K L L K + L+ + D
Sbjct: 3376 SKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTEND 3435
Query: 3855 REKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP---ISDFLSVTEKKL 3911
+ + +L +W LL A + E++ K E E I D L ++
Sbjct: 3436 GICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEELPEI 3495
Query: 3912 ANSEPVGTQTAKIQQQIIRHKALEEDIENH---ATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
+ ++ T T ++ + + E++E T + Q ++ Q++ + E
Sbjct: 3496 SKTKEAAT-TEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVETVPAF 3554
Query: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
++I S++ R +++ + + L+ + F ++ + + N+ +
Sbjct: 3555 QEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSF-------- 3606
Query: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLL----IQEKLDGIK 4084
Q++ + H + EE+ + K +N L+ E + I+ +++ +
Sbjct: 3607 -QNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECR 3665
Query: 4085 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQ 4144
DI S + + + K EE+ L VE+ L + I +
Sbjct: 3666 KALEDIDEKISNEVLKSSPSYAMRRKI----EEINNGLHNVEKML------QQKSKNIEK 3715
Query: 4145 FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 4204
Q+ QK++ E+ L+ ++ + ++E P +A+E +D L+ +QY+ VS
Sbjct: 3716 AQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPF-QQYQQVSQRAE 3774
Query: 4205 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPI----RLEQDQTTAQLQVQKA 4260
R +++ A + ++Y + AW+ T L L +T Q+ ++ +
Sbjct: 3775 CRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDS 3834
Query: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320
+ H MD S IF T E T+S+ + ++ L + L
Sbjct: 3835 EQKHNLLHSIFMD--LEDLSIIFET---------DELTQSIQELSNQVTALQQKIMESLP 3883
Query: 4321 RAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPH 4380
+ Q + + E+ + + L S I + + + E+I K
Sbjct: 3884 QIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKT 3943
Query: 4381 IDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK--EEVRQRALALDEAVSQSTQIT 4438
I +++ +L+ P+ G +Q+ + IK E V Q L + V + T
Sbjct: 3944 IAEIVSYQVELR--LPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQT--N 3999
Query: 4439 EFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRR 4498
E+ ++IE + + L N S++ + + P + DK+ + E+E+++ +L +R
Sbjct: 4000 EWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-------EIERMEKQILSLNQR 4052
Query: 4499 GEELI 4503
E+L+
Sbjct: 4053 KEDLL 4057
Score = 108 bits (269), Expect = 2e-22
Identities = 158/821 (19%), Positives = 326/821 (39%), Gaps = 59/821 (7%)
Query: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE-LMLKKATDETDRDIIREPLTELKHLWEN 4750
+V +QL + + VE+ + + KL +GE L L A + + + +L+ + ++
Sbjct: 4667 SVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYA--------LLQEVYKLEDVLDS 4718
Query: 4751 LGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV-IEVELAK 4809
+ + R +L + Q L+ ++ + +E L KV ++ ++
Sbjct: 4719 MWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIEN 4778
Query: 4810 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT---EE 4866
H V ++A ++ + A L S L+ W + + EE
Sbjct: 4779 HKVFFQKLVADMLLIQAYS--------------AKILPSLLQNRETFWAEQVTEVKILEE 4824
Query: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926
+ +Q LQ E ++ L + L ++ P+ L E E+L + Y Q+
Sbjct: 4825 KSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQI 4884
Query: 4927 K----AKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
K K Q L++G+ ++ S S + E +A LE++W ++ K++ +L+
Sbjct: 4885 KRNIGGKHARLYQTLNEGKQLVA----SVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQ 4940
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL----ILNTVLSQIEEHKVFANEVNA 5038
L + + WL ++ +LN SL L+T+ S I F+ EV+
Sbjct: 4941 ALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDE 5000
Query: 5039 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 5098
+ GNQL L ++ D ++ L + +W ++ + + L +
Sbjct: 5001 KSSLKTAVISIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKL 5059
Query: 5099 QFHEAWKKLIDWLEDAESHLDSE--LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTI 5156
+A ++I W+ + E E + + ++K L KHKEF+ + KQ + D
Sbjct: 5060 PSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDF-- 5117
Query: 5157 RTGRALKEKTLLPEDSQKLD-----NFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 5211
++L + + +S++ + LGE+ +W V G + LE+ L +
Sbjct: 5118 -VNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESE 5176
Query: 5212 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRE 5271
+ +Q L +WL E +L Q + + L+D + + +L ++ + LK+S
Sbjct: 5177 NKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDI-ENQLAIKSKALDELKQSYLT 5235
Query: 5272 LIENS----RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
L + D + + Q+ S+ V +L S QS L++ +++ + M +
Sbjct: 5236 LESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIR 5295
Query: 5328 W---LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 5384
+ + ++ + L E LQSL D + E+ + + + + +
Sbjct: 5296 FWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEII 5355
Query: 5385 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 5444
C T K W + +A +++ Q + + A A L ++ + Q A +
Sbjct: 5356 EEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANIS 5415
Query: 5445 LIQRD-QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484
+ + E +P + +K L + Q E + +DR+
Sbjct: 5416 MSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRL 5456
Score = 105 bits (263), Expect = 1e-21
Identities = 377/2035 (18%), Positives = 792/2035 (38%), Gaps = 291/2035 (14%)
Query: 1957 DSLNLCLQQYEDLKQPMAERKAQ----------LDALAFDIQFFISEHAQDLSPQQNRQM 2006
+ L Q EDL+Q + + Q LD F++ +S+ S ++ +M
Sbjct: 4496 EELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLS--SVEEMLEM 4553
Query: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNT-----CHQQLEDL 2061
RL E Q E A ++ L L + + L +NT C L+ +
Sbjct: 4554 PRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQ-V 4612
Query: 2062 CSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEE 2121
C + +A A + ++ + L + Q+++K L + TS + +I G
Sbjct: 4613 CL---EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISG---- 4665
Query: 2122 NQTKLSPRELTALREKLHQAKEQYEALQE-ETRVAQKELEEAVTSALQQETEKSKAAKEL 2180
++ E+L +A L+ E+RVA+ L+ E E+ L
Sbjct: 4666 ----------QSVAEQLQKADAYTVELENAESRVAK----------LRDEGERLHLPYAL 4705
Query: 2181 AENKKKIDALLD--W---------VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDG 2229
+ K++ +LD W ++S + Q L GM +L EK A G
Sbjct: 4706 LQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLA----HG 4761
Query: 2230 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQ 2289
++ ++ L Q E K Q+L++ ++ SA+ + T +Q+ +
Sbjct: 4762 HLKQTKSKVALQAQIENHKVFFQKLVADM--LLIQAYSAKILPSLLQNRETFWAEQVTEV 4819
Query: 2290 KLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSS 2349
K+ E K + +LQ LQ +EF+ EK+LE +
Sbjct: 4820 KILEEKSRQCGM----------------KLQSLLQKWEEFDENYASLEKDLEIL------ 4857
Query: 2350 PETLPSLL---KRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKE--PSEIGNLV 2404
TLPS+ + + E + ++ R + G K + + EGK+ S +
Sbjct: 4858 ISTLPSVSLVEETEERLVERISFYQQIKRNI---GGKHARLYQTLNEGKQLVASVSCPEL 4914
Query: 2405 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE--ANVEKLLS 2462
+ ++ E++ +L+ K L LL + +D L W+++ + N K S
Sbjct: 4915 EGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQS 4974
Query: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
V+ D ++ + + +E+ E + + ++ H++ET
Sbjct: 4975 LNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLL-----------HLKETDT 5023
Query: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
+ +L SLA+ I Q +QE L L ++E+ K ++ + S +
Sbjct: 5024 A------TLRASLAQFEQKWTMLITQLPDIQEKLHQL-----QMEKLPSRKAITEMISWM 5072
Query: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFME----------TADSTTAAVLQGKLAE 2632
T+ +D SS + ++ + E D ++LQ +
Sbjct: 5073 NNVEHQTS---DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCD 5129
Query: 2633 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2692
V + + E+ + L + + G L + +++ ++L S IT
Sbjct: 5130 VESK-------RYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLES-------ITES 5175
Query: 2693 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR--------VQNLRKDFT 2744
+IQ LN +E Q+E L TL+ + +S LD CQ + + L++ +
Sbjct: 5176 ENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLD-CQDIENQLAIKSKALDELKQSYL 5234
Query: 2745 ELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP---------TETSMSAK 2795
L+ +D +S ++L + R V T LK + S+ E +M
Sbjct: 5235 TLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTI 5294
Query: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855
+EH K ++ +E + C+ +L++L E A S+G + +G
Sbjct: 5295 RFWYCMEHSKPVV-------LSLETLRCQVENLQSLQDE--AESSEGSWEKLQEVIGKLK 5345
Query: 2856 GSVNGYHTCKDLTE-IQCDMSDVNLKYEKLGGVLHERQESLQAIL---NRMEEVHKEANS 2911
G C + E I+ + + ++ ++ + ++ + Q++L H EA +
Sbjct: 5346 G------LCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAA 5399
Query: 2912 VLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL---AG 2968
L+ E+K + L ++ +MS E + L ++++ +QK KEA +
Sbjct: 5400 RLKQQEAKFQQLANI-SMSGNNLAEILPPA-------LQDIKELQHDVQKTKEAFLQNSS 5451
Query: 2969 LLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 3028
+L P E+ + L+S +RA + ++ L A+ F+ SQ + +
Sbjct: 5452 VLDRLPQPAESSTHMLLPGPLHS-LQRAAYL----EKMLLVKANE---FEFVLSQFKDFG 5503
Query: 3029 MEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQH---EQLNEAAQGILTGPG 3084
+ E + G++ + + L+ Q K+ L A Q E LNE +
Sbjct: 5504 VRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-------- 5555
Query: 3085 DVSLSTSQVQ-KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
+ L S V K LQ++N++W+ T R S++ Q I + ++ + + + +
Sbjct: 5556 -LKLPLSDVAVKTLQNMNRQWIRATATALERCSEL-QGIGLNEKFLYCCEKWIQLLEKIE 5613
Query: 3144 QRLSVQSAISTQPEAVKQQLEE---TSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
+ L V A ++ PE ++QQ +E+ + D V ++ L D + +++
Sbjct: 5614 EALKVDVA-NSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFI- 5671
Query: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL-DDKQSQQAKN 3259
E K + +QG+ D + + Q F + L +L D A
Sbjct: 5672 TEFSKLTDRWQNAVQGVRQRKGD----VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVK 5727
Query: 3260 CPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 3319
L + +S + E + + + + + + GE LLL+ + K ++ ++ +
Sbjct: 5728 GQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDL-KTKESVGRRISQ 5786
Query: 3320 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QL 3378
L++ W+++ + A+ + + ++ + + +++L ++ KA+ DP+ +L
Sbjct: 5787 LQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSE------DPLPEL 5840
Query: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEEL 3438
L K ++ E+E+ S A N E ++ KA + +++ + E++
Sbjct: 5841 HEDLHNEKELIKELEQ---------SLASWTQNLKE-----LQTMKADLTRHV--LVEDV 5884
Query: 3439 QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACS------NKNLEKL 3492
+E + ++ + ++++E + +F+ + C+ NK L+
Sbjct: 5885 MVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTA 5944
Query: 3493 RAQ-QEVLQALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSG 3550
+E+++ L+ ++ + F++ ++ G + +++ A E+ ++N
Sbjct: 5945 DISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA-----EIDDKLNKI 5999
Query: 3551 CVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA-IGRDTDSLQSQI-------EDV 3602
++ + IG +++E F+ + LD + + + R L + +++
Sbjct: 6000 NDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEI 6059
Query: 3603 RLFLNKIHVLKLDIEASEAE-------CRHMLEEE----GTLDLLGLKRELEALNKQCGK 3651
+ L + L+ DIE A C +L + + +++ +L+++
Sbjct: 6060 QKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRN 6119
Query: 3652 LTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADF 3711
+ R+ ++E T + F D +AE A ++L F
Sbjct: 6120 ICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRF 6179
Query: 3712 KMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRI 3771
+ FQ+ Q+ +L+ +N + L + D L+ + E N RW+ L ++V +
Sbjct: 6180 EAFQR-QIHERLTQLELINKQYRRLARENRTD-TASRLKQMVHEGNQRWDNLQRRVTAVL 6237
Query: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQK---PPSAEYKVVKAQIQEQKLLQRL 3828
+L+ +F+ E +L WL + + + N + A+ K+ + +Q++
Sbjct: 6238 RRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEI---T 6294
Query: 3829 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQL 3883
L+ K +D L G ++ Q +E D I +LE L E+ + + ++L
Sbjct: 6295 LNTNK--IDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRL 6347
Score = 101 bits (251), Expect = 3e-20
Identities = 582/3278 (17%), Positives = 1245/3278 (37%), Gaps = 498/3278 (15%)
Query: 2091 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL----SPRELTALREKLHQAKEQYE 2146
Q+ +++ ++ +Q +K++ + +L S +EL + + Q Q E
Sbjct: 813 QAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRE 872
Query: 2147 ALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLT 2206
+ E + K E + S + + KA +EL N + D S+ +
Sbjct: 873 SPGE---LISKHKEALIISNTKSLAKYLKAVEELKNNVTE-----DIKMSLEEKSRDVCA 924
Query: 2207 NLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMK-----ARHQELLSQQQNF 2261
+ +++ +D G + N KL+KQ K R + L+ + +
Sbjct: 925 KWESLHHELSLYVQQLKIDIEKGKLSDNIL--KLEKQINKEKKLIRRGRTKGLIKEHE-- 980
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK 2321
A S + L Q H++ + L EL E+ + +Q E + + ++ + ++++
Sbjct: 981 --ACFSEEGCLYQLNHHM---------EVLRELCEELPSQKSQQEVK-RLLKDYEQKIER 1028
Query: 2322 FLQDHKEFESWLE-------RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDL 2374
L+ E L+ ++E + G P + K S + + + +
Sbjct: 1029 LLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEK-AMEPTM 1087
Query: 2375 RFVTISGQKVLDMENSFKEGKEPSEIGNLVK--DKLKDATERY---------TALHSKCT 2423
+F S + L E S E + I +L++ D +D E + + S+
Sbjct: 1088 KFSLASVLRPLQ-EESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEED 1146
Query: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
R S L L +N D+ + +E ++D P V++E+ ++ +
Sbjct: 1147 RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDI--KKPFVIKERDTLKERER 1204
Query: 2484 EELAEHQVPVEKLQKVARDIMEIE-------GEPAPDHRHVQE-----TTDSILSHFQSL 2531
E +E L+ R ++ +E G P H+ + D I H +++
Sbjct: 1205 ELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNI 1264
Query: 2532 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2591
S+A++ + + V + L +L Q +I +
Sbjct: 1265 QDSIAKQIEICNRLEEPGNFVLKELHPF---------DLHAMQ------NIILKYKTQFE 1309
Query: 2592 KLKQDIARQKSSLEATREMVTRFMETADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKES 2649
+ + R + +L+A + + + TA + V L +V+Q L ++ +E E
Sbjct: 1310 GMNHRVQRSEDTLKALEDFLAS-LRTAKLSAEPVTDLSASDTQVAQE-NTLTVKNKEGEI 1367
Query: 2650 SLKKLLPQAEMFEHLSGKLQQF-MENKSRMLASGNQPDQDITHFFQQIQELN---LEMED 2705
L K + +HL L+ M K + + F ++ E + ++ E
Sbjct: 1368 HLMK-----DKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEF 1422
Query: 2706 QQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQK---------TVKEREKD 2756
+EN L +C F ++ + ++N++ +++ K VK R+K
Sbjct: 1423 TEEN--------KLLEACIF-----KNNELLKNIQDVQSQISKIGLKDPTVPAVKHRKKS 1469
Query: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT 2816
+ LDE+ + R Q E S+P + K + +Q ++ L ++ +K
Sbjct: 1470 LIRLDKVLDEYEEEKRHLQ----EMANSLPHFKDGRE-KTVNQQCQNTVVLWEN--TKAL 1522
Query: 2817 LVEEINCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871
+ E + G LE L I Q K S++ S +G N K + EI+
Sbjct: 1523 VTECLEQCGRVLELLKQYQNFKSILTTLIQ-KEESVISLQASYMGKEN---LKKRIAEIE 1578
Query: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVH-----KEANSVL-QWLESKEEVLKS 2925
+ N E + + ++ ++LQ LN+M+ KEAN ++ +WL+ E K+
Sbjct: 1579 IVKEEFNEHLEVVDKI-NQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINE---KT 1634
Query: 2926 MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI 2985
D + + + + + K + E + + +QK++ + E+ +++
Sbjct: 1635 EDYYENLGRALALWDKLFNLKNVIDEWTEKA--LQKMEL----------HQLTEEDRERL 1682
Query: 2986 QEELNSRWERATEVT--VARQRQLEESASHLACFQAAESQLRPWLMEKE----------L 3033
+EEL ++ +E + VA + L +S+ Q ES + + +
Sbjct: 1683 KEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA 1742
Query: 3034 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQH--EQLNEAAQGILTGPGDVSLSTS 3091
+ G L D + Q + +LK +L E Q IL + L +
Sbjct: 1743 LSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLEN 1802
Query: 3092 QV---QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV 3148
Q+ EL + +++ ++D N++ S V + +LL D + + V
Sbjct: 1803 QIGCLTPELSELKKQYESVSDLFNTKKS------VLQDHFSKLLNDQCKNFNDWFSNIKV 1856
Query: 3149 QSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK 3205
+ K+ +E+ + SD LE + ++K+ ++ + + + ++K EL
Sbjct: 1857 NLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVK-ELIS 1915
Query: 3206 RLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAK 3265
L L+ +E + R L+ +L + Q LR WL +++ + K
Sbjct: 1916 WLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEK 1975
Query: 3266 LERL-QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEK-RTLQNQLVELKNH 3323
E Q+ ++ E+F+ ++ E E E +++ ++ +TL QL E++
Sbjct: 1976 TELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEE- 2034
Query: 3324 WEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLL 3383
E+ T D Q + D++ WI++ K + L + + LE +
Sbjct: 2035 -EDKLLPTED------------QSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQ 2081
Query: 3384 RSKAMLNEVEKRRSLLEILNSAADI----LINSSEADEDGIRDEKAGINQNMDAVTEEL- 3438
+ K ++ + + +E + A+ L+ + D D + + E+L
Sbjct: 2082 KIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLL 2141
Query: 3439 -------QAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEK 3491
Q+K L M L++ QE+ ++ ++ K QL+I+ K L+K
Sbjct: 2142 LEGEKYLQSKE-DLRLMLIELKKKQEAGFALQHGLQEKKAQLKIY---------KKFLKK 2191
Query: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGC 3551
+ +L+ L+ Q +YL T+ +++ +LE+K S
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKN-----------------PSFSEEPWLEIKHLHESLL 2234
Query: 3552 VMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAI-------GRDTDSLQSQIEDVR 3603
+++ ++ + H R + + + DL+ LD D +++ +++ ++
Sbjct: 2235 QQLQDSVQNLDG-HVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQ 2293
Query: 3604 LFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQL 3663
N++ + ++ A + + + ++ +K ++++L + L R + ++++
Sbjct: 2294 ELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEM 2353
Query: 3664 ELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVE--IINQQLADFKMFQKEQVDP 3721
E L + R + T E +A V + E + + D+++ + V+
Sbjct: 2354 ECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLEEDWEINKDSAVEM 2413
Query: 3722 LQMKLQQVNGLGQ----------GLIQSAGKDCDVQGLEHDMEEINARWNTLN-KKVAQR 3770
K +N +Q+ + D +EEI + L KK A +
Sbjct: 2414 AMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIK 2473
Query: 3771 IAQLQEAL---------LH-CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
+ E L LH G L+ LL + LI +K ++Y V++ Q
Sbjct: 2474 PLEQTECLNKTETGALVLHNIGYSAQHLDNLL------QALITLKKNKESQYCVLR-DFQ 2526
Query: 3821 E-----QKLLQRLLDDRKAT-VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3874
E + ++ LL D+++ V L + +A EK L +L+ +W L +
Sbjct: 2527 EYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIKWENLSN 2586
Query: 3875 KAAARQKQLEDILV-------------LAKQFHETAEPISDFLSVTEKKLANSEPVGTQT 3921
K+L + + + K++ + +F ++ K + Q
Sbjct: 2587 HVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQQQ 2646
Query: 3922 AKIQQQIIRHKALEEDIENHA-----TDVHQAVKIGQS---------LSSLTSPAEQGVL 3967
+Q +R K+ EE N + TD+ QA K G S + + E+ L
Sbjct: 2647 QHLQ---LRLKSPEERAGNQSMIALTTDL-QATKHGFSVLKGQAELQMKRIWGEKEKKNL 2702
Query: 3968 SEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKD 4027
+ I++L+ ++ ++ + + ++ E + W + +L+ +
Sbjct: 2703 EDGINNLKKQWETLEPLHLEAENQIKKCDIRNKM-----KETILWAKNLLGELNPS-IPL 2756
Query: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRY 4087
D+L + + ++ I+ R+++V+ + + + T E + L+ ++ +Y
Sbjct: 2757 LPDDILSQIRKCKVT-HDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQY 2815
Query: 4088 ADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEE----ELATSGGQSPTGEQIP 4143
+ + S++ + LE + + F + + ++E E + T+ ++
Sbjct: 2816 QMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHV 2875
Query: 4144 QFQQRQKELKK-------EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQY 4196
+ QKEL++ + E + + +N R LE + L L N
Sbjct: 2876 TLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLE-------DQLKNLKIRTNRIQ 2928
Query: 4197 KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGP-----IRLEQDQT 4251
+ + +T +E++ I+ +Q+ + A +R + L ++ E
Sbjct: 2929 RFIQNTC----NEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984
Query: 4252 TAQLQVQKAFSIDIIRHKDSMDEL-----FSHRSEIFGTCGEEQKTVLQEKTESLIQQYE 4306
+L K + +++ K D + FS ++ E++K L+EK I+Q +
Sbjct: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKE-LEEK----IKQLD 3039
Query: 4307 AISLLNSERYARLERAQVL---VNQFWETYEELSPWIEETRALIAQLPSPAIDH-----E 4358
+ + A L + + + + + E + E+R L AQ+ S I+ +
Sbjct: 3040 TFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCD 3099
Query: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418
++ ++ E + +S E + +L+I +LN EE + + Y+ +NM ++
Sbjct: 3100 EIIKKLNENKTFDDSFKEKE-----ILQI-----KLNAEENDKL---YKVLQNMVLELSP 3146
Query: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE----C 4474
+ LDE Q DK+E L L + S+L+ P LI E+ I+ C
Sbjct: 3147 K------ELDEKNCQ--------DKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNC 3192
Query: 4475 ISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQD---KLDQMVFFWED 4531
+ + E+ ++ + A++++ EE S+ +D + +E +D +L+ + +
Sbjct: 3193 EAFQEQVWAEMCSIK-AVTAIEKQREE--NSSEASDVETKLREFEDLQMQLNTSIDLRTN 3249
Query: 4532 IKARAEEREIKFLDVLELAEKFWYDMAALLTTIK-DTQDIVHDLESPGIDPSIIKQQVEA 4590
+ A E ++ + + A + + A++ + D + LE P +++Q E
Sbjct: 3250 VLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMP------LRKQEEL 3303
Query: 4591 AETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLE 4650
T+ D L E+L G PE + + + N KE +
Sbjct: 3304 ESTVAHIQD-LTEKL--------------GMISSPEAKLQLQYTLQELVSKNSAMKEAFK 3348
Query: 4651 KLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-----MPPVGTDLNTVKDQLNEMKEFKV 4705
E + ++ + M + + + K+ T M + ++L + K
Sbjct: 3349 AQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVS 3408
Query: 4706 EVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE---------PLTELKHLWENLGEKIA 4756
+ + E+ KL L+ + T+ +++ L E WE E++
Sbjct: 3409 NLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELK 3468
Query: 4757 HR----QHKLEGALLALGQFQHALEELMSW--LTHTEELLDAQRPISGDPKVIEVELAKH 4810
++E + L Q L E+ TEEL + + + +E K
Sbjct: 3469 QEWKFVSEEIEREAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVE----KQ 3524
Query: 4811 HVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4870
+L +L +++ V ++ + A + +S++ R + LQK ++ ++
Sbjct: 3525 QLLLTLLLQRIRSIQNVPESSGAVETVPAFQEITSMKERCNKL-------LQKVQKNKEL 3577
Query: 4871 LQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE 4930
+Q+ +Q+ F EI + L Q + S + E+ + EL S LK +
Sbjct: 3578 VQTEIQERHSFTKEI----IALKNFFQQTTTSFQNMAFQDHP-EKSEQFEELQSILKKGK 3632
Query: 4931 ETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE-------- 4982
T+ +++K R+ K + ++ + + S++EE + LE
Sbjct: 3633 LTFENIMEKLRI------------KYSEMYTIVPAE---IESQVEECRKALEDIDEKISN 3677
Query: 4983 EALNLATEF--QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
E L + + + ++E N L E+ L S + E K +E++
Sbjct: 3678 EVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKS------KNIEKAQEIQKKMWDELDLWH 3731
Query: 5041 DQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQF 5100
++ ELD + Q + NL++ Q ++++V QR+ R L+ A + +++
Sbjct: 3732 SKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQ-QYQQVSQRAECRTSQLNKATVKMEEY 3790
Query: 5101 HEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH 5138
+ K W+E+ SHL ++N D L+ H
Sbjct: 3791 SDLLKSTEAWIENT-SHL-----LANPADYDSLRTLSH 3822
Score = 97.4 bits (241), Expect = 4e-19
Identities = 130/690 (18%), Positives = 276/690 (40%), Gaps = 60/690 (8%)
Query: 4840 GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQL 4899
G++ + L + + C E R + L++ L + + +EI+ +L + ++ L
Sbjct: 4597 GENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSL 4656
Query: 4900 SAS-KPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQ 4958
S G ++ EQL +L+ E +L D+G + L K E
Sbjct: 4657 QQSLNEISG--QSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLED 4714
Query: 4959 SVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS--LQEFINWLTLAEQSL---NIAS 5013
+L+ W ++ ++ E S TE Q LQ + + + ++ L ++
Sbjct: 4715 ---VLDSMWGMLRARYTELSSPF------VTESQQDALLQGMVELVKIGKEKLAHGHLKQ 4765
Query: 5014 PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQ 5073
S + + +QIE HKVF ++ A L Q ++ +LL + +
Sbjct: 4766 TKSKV--ALQAQIENHKVFFQKLVADM--------------LLIQAYSAKILPSLLQNRE 4809
Query: 5074 SRWEKVV-------QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
+ W + V ++S + G L ++ ++F E + L LE S L S +
Sbjct: 4810 TFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEE 4869
Query: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 5186
+++ ++S +++ ++ +GGK T+ G+ L PE L+ + ++ ++W
Sbjct: 4870 TEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPE----LEGQIAKLEEQW 4925
Query: 5187 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQL----AEDQPVHGDLDLVM 5242
++ K H+L+ L + L WL + L + V DLD +
Sbjct: 4926 LSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIR 4985
Query: 5243 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 5302
+ ++ F KE+ +++ + G +L+ DT ++ L + +W +
Sbjct: 4986 SNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLP 5045
Query: 5303 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL--PDDTEALQSLIDTHKEFM 5360
Q +L Q + R + ++ W++ E ++ P ++ L+ HKEF
Sbjct: 5046 DIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFR 5105
Query: 5361 KKVEEKRVDVNSAVAMGEVILAVCHPDC----ITTIKHWITIIRARFEEVLTWAKQHQQR 5416
+++ K+ V+ V + L+ C + T + + ++ V + Q
Sbjct: 5106 MEMDYKQWIVD-FVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQH 5164
Query: 5417 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476
LE L + + ++ L W++ E L + P+++ V+ L+ + Q ++
Sbjct: 5165 LEQLLESITESENKIQILNNWLEAQEERLKTLQK---PESVISVQKLLLDCQDIENQLAI 5221
Query: 5477 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRS 5506
K +D + ++Y +E P +E + S
Sbjct: 5222 KSKALDELKQSY--LTLESGAVPLLEDTAS 5249
Score = 83.2 bits (204), Expect = 7e-15
Identities = 385/2184 (17%), Positives = 812/2184 (37%), Gaps = 318/2184 (14%)
Query: 3339 KDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVEKR 3395
KD ++ Q V+D + W+ K K+ +L + + +SLL NE ++
Sbjct: 286 KDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNE--EK 343
Query: 3396 RSLLEILNSAADILINSSEADEDGIRDEKA--GINQNMDAVTEELQ-AKTGSLEEMTQRL 3452
+S L++L+ D+ E D+D ++ +A G++ ++A +L A L + L
Sbjct: 344 KSFLDVLSIKRDL----DELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWL 399
Query: 3453 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNF 3512
+E +E + + + EK+ + ++ E + L F
Sbjct: 400 QEVEELMDEDLSASQDHSQAVTLIQ------------EKMTLFKSLMDRFEHHSNILLTF 447
Query: 3513 TQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMF 3572
+ D + H V + E+K+R+N+ ++E K + +FH +
Sbjct: 448 ---------ENKDEN---HLPLVPPNKLEEMKRRINN---ILEKKFILLLEFHYYKCLVL 492
Query: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3632
+ ++ +LD +S++ +ED F+ + L ++ S +C + +
Sbjct: 493 GLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLAR-LDTSFQKCGEIYKN--- 548
Query: 3633 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEA 3692
L E + +NKQ + D K + + + ++ A
Sbjct: 549 -----LAGECQNINKQYMMVKS-----------------DVCMYRKNIYNVKSTLQKVLA 586
Query: 3693 LQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQ 3747
W T VE + A F+ +KE++ + + L + AG DV
Sbjct: 587 C-WA--TYVENLRLLRACFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVV 643
Query: 3748 G--LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3805
G + ++ +N RW L K QL+ L K QD +P ++ +++ +
Sbjct: 644 GSSISKELRRLNKRWRKLVSKT-----QLEMNLPLMIKKQD--QPTFD---NSGNILSKE 693
Query: 3806 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3865
+ + E+ + + Q + K + + G Q D EK+ GQ+E
Sbjct: 694 EKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTG----QLKVAKDVEKLIGQVEIW 749
Query: 3866 ESRWTELLSKA---AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3922
E+ +L + + ++ L+ ++ F E D L + + +++ E
Sbjct: 750 EAEAKSVLDQDDVDTSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQESF----- 804
Query: 3923 KIQQQIIRHKALEEDIENHATDVH-QAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 3981
Q + L+ I+ V VK+ +L +LT + + K++ Q E+
Sbjct: 805 ----QHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQ---KEL 857
Query: 3982 QDRCCRKAALLDQALSNARLFGEDEVEVL--------NWLAEVEDKLSSVF------VKD 4027
+ R LL Q S L + + ++ +L VE+ ++V +++
Sbjct: 858 ESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEE 917
Query: 4028 FKQDVLHRQHADHLALNEEIVNRKKNVDQA--IKNGQALLKQTTGEEVLLIQEKLDGIKT 4085
+DV + + H L+ + K ++++ N L KQ E+ L+ + + G+
Sbjct: 918 KSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIK 977
Query: 4086 RYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQF 4145
+ + + L L ++ LRE+ EEL + Q + +
Sbjct: 978 EH-EACFSEEGCLYQLNHHMEV--------------LRELCEELPSQKSQQEVKRLLKDY 1022
Query: 4146 QQRQKELKKEVME-HRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIG 4204
+Q+ + L K E H + T S+ + R G D + +
Sbjct: 1023 EQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGG------DPHSEAPFAKS--- 1073
Query: 4205 QRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR----LEQDQTTAQLQVQKA 4260
+ A++ + ++ A+ L P++ +E+D + + + +
Sbjct: 1074 DNQPSTEKAMEPTMKFSLAS---------------VLRPLQEESIMEKDYSASINSLLER 1118
Query: 4261 FSI--DIIRH-----KDSMDELFSHRSEIFGTCGEEQKT---VLQEKTESLIQQYEAISL 4310
+ DI+ H K + FS + +C + + T V++ +T++ +++E ISL
Sbjct: 1119 YDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISL 1178
Query: 4311 -------------LNSERYARLERA---QVLVNQFWETYE---ELSPWIEETRALIAQLP 4351
+ ER ER Q+ +N E+ E L +E+ L+
Sbjct: 1179 KLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSD 1238
Query: 4352 SPA----------IDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP-QLKELNPEEGE 4400
P ID +++ Q +R +++SIA+ ++L + G LKEL+P +
Sbjct: 1239 LPLHKMAIQGFHLIDADRIYQH---LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLH 1295
Query: 4401 MVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRM 4460
++ K + + + V++ E L+ LE+ + LR
Sbjct: 1296 AMQNIILKYKTQFEGMNHRVQRS---------------------EDTLKALEDFLASLRT 1334
Query: 4461 PPLIPAEVDKIRECISDNKSA---TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4517
L V + SD + A T+ ++ + +K + + L + D E
Sbjct: 1335 AKLSAEPVTDLSA--SDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
Query: 4518 IQDK------LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
D LD + + E F + +L E + LL I+D Q +
Sbjct: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEE--FTEENKLLEACIFKNNELLKNIQDVQSQI 1450
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4631
+ +K + ++ + + D EE ++ + L EK V +
Sbjct: 1451 SKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKT-VNQQC 1509
Query: 4632 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4691
WEN E LE+ ++ QYQ+ +++ L + ++
Sbjct: 1510 QNTVVLWENTKALVTECLEQCGRVLELLKQYQN-FKSILTTLIQKEESVISLQASYMGKE 1568
Query: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNH-----QGELMLKKATDETDRDIIREPLTELKH 4746
+K ++ E++ K E + ++K+N Q L K +E + +
Sbjct: 1569 NLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPP---FEKEANIIVD 1625
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
W ++ EK L AL + + + W + ++ + D + ++ E
Sbjct: 1626 RWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEE 1685
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW--ESVLQKT 4864
L H ++ A ++ + ++ LE + SS+ +++E + +C ES
Sbjct: 1686 LQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVME--SSILNKMEHVQKCLTGESNCHAL 1743
Query: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYS 4924
+L+ L QA+ ++ ES L A P+ L E+++
Sbjct: 1744 SGSTAELREDLDQAK----------TQIGMTESLLKALSPSDSL------------EIFT 1781
Query: 4925 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 4984
+L EE Q+L + M+L + G ++ L++++ VS +KS L++
Sbjct: 1782 KL---EEIQQQILQQKHSMILLENQIGC---LTPELSELKKQYESVSDLFNTKKSVLQD- 1834
Query: 4985 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQII 5044
+ + + + F +W + + +L S +V ++++ F + +I
Sbjct: 1835 -HFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFLT-LEGRNSKIK 1892
Query: 5045 ELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAW 5104
++D +K K V + + LV + EK+ R + L+D+ ++ + +
Sbjct: 1893 QVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLLRLQDDH 1952
Query: 5105 KKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKE 5164
+ L WL + E E K + F + L K+ +++ + +LKE
Sbjct: 1953 RNLRKWLTNQEEKWKGMEEPGE----------KTELFCQALARKREQFESVAQLNNSLKE 2002
Query: 5165 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 5224
E+ ++ + D++ T+ + E + + + F D ++ W+ ++
Sbjct: 2003 YGFTEEEEIIMEATC--LMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEI 2060
Query: 5225 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-----SRDD 5279
+ L +V+N + ++ + K + +LK G IE +
Sbjct: 2061 KESL-----------MVLNSSEGKMPLEERIQKIKEII-LLKPEGDARIETIMKQAESSE 2108
Query: 5280 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 5339
V+ L ++S +WD L+ + S E+ L + E + + L L E ++
Sbjct: 2109 APLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKKKQEAG 2168
Query: 5340 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 5399
AL + ++ + +K+F+KK ++ + + G +L C + + + W+ I
Sbjct: 2169 FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLE-CTKNPSFSEEPWLE-I 2226
Query: 5400 RARFEEVLTWAKQHQQRLETALSE 5423
+ E +L + Q L+ + E
Sbjct: 2227 KHLHESLLQQLQDSVQNLDGHVRE 2250
Score = 59.7 bits (143), Expect = 8e-08
Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 32/258 (12%)
Query: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE---ELLDAQRPISGDPKVIE 4804
WE + + H + K++ L Q + + +WL TE E+L +P S D + IE
Sbjct: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS-DIQEIE 6590
Query: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
+ + + + ++A V +VN + E L++ + +++ L+SRL ++ WE+
Sbjct: 6591 LRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTES-PESTELQSRLRQLSLLWEAAQGAV 6649
Query: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTG------GLPETAREQLDT 4918
+ L+ +L Q Q FH ++ LL L +++ + T L E RE +
Sbjct: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
Query: 4919 HMELYS---QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME 4975
EL Q+ +E N LL KG + E+K HV+ K++
Sbjct: 6710 EKELVERQPQVDMLQEISNSLLIKGH---------------GEDCIEAEEKVHVIEKKLK 6754
Query: 4976 ERKSKLEEALNLATEFQN 4993
+ + ++ + L QN
Sbjct: 6755 QLREQVSQDLMALQGTQN 6772
Score = 53.5 bits (127), Expect = 6e-06
Identities = 72/337 (21%), Positives = 139/337 (41%), Gaps = 22/337 (6%)
Query: 3858 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3917
IT Q RW + ++ + +++ L +Q + I+ +L TE +L + +
Sbjct: 6524 ITEQQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLK-M 6579
Query: 3918 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL----TSPAEQGVLSEKIDS 3973
+ IQ+ +R K L+E ++ A D ++A+ + ++SS T E L ++
Sbjct: 6580 AKPPSDIQEIELRVKRLQEILK--AFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQ 6637
Query: 3974 LQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD-- 4031
L + Q L Q+L + F + +L WLA +++ V D K D
Sbjct: 6638 LSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPR 6697
Query: 4032 VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT 4091
L + + L +E+V R+ VD + +LL + GE+ + +EK+ I+ + +
Sbjct: 6698 ALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6757
Query: 4092 VTSSKALRTLEQARQLATKFQSTYEELTGWLREVE----------EELATSGGQSPTGEQ 4141
S+ L L+ + A+ S E +G + T+ G+ T +
Sbjct: 6758 EQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESR 6817
Query: 4142 IPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
+P + Q+ V+ L L + + L L+P
Sbjct: 6818 VPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLP 6854
Score = 51.2 bits (121), Expect = 3e-05
Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 8/234 (3%)
Query: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
Q QQ A W+ +T+ +L L + D +L+V++ +I++ D+
Sbjct: 6551 QNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQ--EILKAFDTYKA 6608
Query: 4275 LF---SHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWE 4331
L + S+ F + T LQ + L +EA L ++ + F +
Sbjct: 6609 LVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQ 6668
Query: 4332 TYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 4389
+ L W+ + R A + P D L + + E+ QL + + E +P +D L +I
Sbjct: 6669 LSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISN 6728
Query: 4390 QLK-ELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
L + + E+ EEK E Q++E+V Q +AL + ++ + F +
Sbjct: 6729 SLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDE 6782
Score = 50.8 bits (120), Expect = 4e-05
Identities = 48/216 (22%), Positives = 94/216 (43%), Gaps = 18/216 (8%)
Query: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDL--- 5240
D+W+ + + + + K+++ L Q + A+ WL K E +L + D+
Sbjct: 6533 DRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEI 6589
Query: 5241 ---VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTV 5297
V L + K F V + S +E ++ ++T ++ +L++LS W+
Sbjct: 6590 ELRVKRLQEILKAFDTY----KALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAA 6645
Query: 5298 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 5357
S + L Q+L Q + F LL WL+ A+ R + + D ++L++ +
Sbjct: 6646 QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR-RQKAHVTDPKADPRALLECRR 6704
Query: 5358 EFM---KKVEEKRVDVNSAVAMGEVILAVCH-PDCI 5389
E M K++ E++ V+ + +L H DCI
Sbjct: 6705 ELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCI 6740
Score = 50.8 bits (120), Expect = 4e-05
Identities = 45/199 (22%), Positives = 85/199 (42%), Gaps = 11/199 (5%)
Query: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELE--NMHKGGSSPETLPSLLKRQGSFSE 2365
EL ++ LQ+ D +WL+++E ELE M K S + + +KR +
Sbjct: 6542 ELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILK 6601
Query: 2366 DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRL 2425
++K + V +S ++ L E+ E +E+ + +L+ + + A
Sbjct: 6602 AFDTYKALVVSVNVSSKEFLQTESP-----ESTEL----QSRLRQLSLLWEAAQGAVDSW 6652
Query: 2426 GSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEE 2485
L L Q F + +L W+ + + +K +DP L E QL++E
Sbjct: 6653 RGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKE 6712
Query: 2486 LAEHQVPVEKLQKVARDIM 2504
L E Q V+ LQ+++ ++
Sbjct: 6713 LVERQPQVDMLQEISNSLL 6731
Score = 44.7 bits (104), Expect = 0.003
Identities = 43/238 (18%), Positives = 100/238 (42%), Gaps = 14/238 (5%)
Query: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ--QAKNCPISAKLERLQSQLQE 3275
E + A ++ + QQ + TWL +++ K + ++ ++ +++
Sbjct: 6536 EMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKR 6595
Query: 3276 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQ 3335
+E K+ + + + + L + P E LQ++L +L WE +
Sbjct: 6596 LQEILKAFDTYKALVVSVNVSSKEFLQTESP--ESTELQSRLRQLSLLWEAAQGAVDSWR 6653
Query: 3336 SRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK- 3394
L+ + + Q + ++L+ W+ K + + VT DP +LL + L ++EK
Sbjct: 6654 GGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT-DPKADPRALLECRRELMQLEKE 6712
Query: 3395 ---RRSLLEILNSAADILINSSEADEDGIRDEKAGI-----NQNMDAVTEELQAKTGS 3444
R+ +++L ++ L+ ++ +EK + Q + V+++L A G+
Sbjct: 6713 LVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGT 6770
Score = 42.4 bits (98), Expect = 0.014
Identities = 64/322 (19%), Positives = 125/322 (38%), Gaps = 49/322 (15%)
Query: 3626 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL-----GRVEDFYRKLKGL 3680
M++ + + L +K+ L+ LN +T K + +LE+ +++ ++K L
Sbjct: 6537 MIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRL 6596
Query: 3681 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3740
+ A + +AL V +N +F + + LQ +L+Q++ L
Sbjct: 6597 QEILKAFDTYKAL-------VVSVNVSSKEFLQTESPESTELQSRLRQLSLL-------- 6641
Query: 3741 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE- 3799
W V L+++L+ C F + LL WLA +
Sbjct: 6642 -------------------WEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKN 6682
Query: 3800 -ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858
A+ P A+ + + +E L++ L +R+ VDMLQ + D +
Sbjct: 6683 RRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEA 6742
Query: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
++ +E + +L R++ +D++ L + A P+ F V + V
Sbjct: 6743 EEKVHVIEKKLKQL------REQVSQDLMAL-QGTQNPASPLPSFDEVDSGDQPPATSVP 6795
Query: 3919 TQTAKIQQQIIRHKALEEDIEN 3940
AK Q + +R EE+ E+
Sbjct: 6796 APRAK-QFRAVRTTEGEEETES 6816
Score = 38.1 bits (87), Expect = 0.26
Identities = 50/230 (21%), Positives = 90/230 (39%), Gaps = 33/230 (14%)
Query: 4570 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4629
I+H L ID +K + + ++E +EL+ R+L + + EK +
Sbjct: 219 IIHALRPDLIDMKSVKHRSNK-DNLREAFRIAEQELKIPRLLEPEDVDVVDPDEK-SIMT 276
Query: 4630 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4689
+ + ++ T +E K++DAM ++ LQ + +N
Sbjct: 277 YVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQKEKLQKLLKDSEN-------------- 322
Query: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749
+T + N + F + EK + L +K+ DE D+D + +L+ W+
Sbjct: 323 -DTYFKKYNSLLSF-----MESFNEEKKSFLDVLSIKRDLDELDKDHL-----QLREAWD 371
Query: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4799
L +I + KL AL L + +WL EEL+D S D
Sbjct: 372 GLDHQINAWKIKLNYAL------PPPLHQTEAWLQEVEELMDEDLSASQD 415
Score = 38.1 bits (87), Expect = 0.26
Identities = 45/255 (17%), Positives = 97/255 (38%), Gaps = 13/255 (5%)
Query: 4638 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV--IKLCTMPPVGTDLNTVKD 4695
WE + K++ +Q Q + A+ WL T +++ M +D+ ++
Sbjct: 6535 WEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIEL 6591
Query: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4755
++ ++E + + +N + L+ + E+ ++ L +L LWE +
Sbjct: 6592 RVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAV 6649
Query: 4756 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPI--SGDPKVIEVELAKHHVL 4813
+ L +L+ F + L+ WL + DP+ + + L
Sbjct: 6650 DSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 6709
Query: 4814 KNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
+ +++ Q V+ + + N LL G+D ++ + E L++ E+ Q
Sbjct: 6710 EKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVI----EKKLKQLREQVSQDLM 6765
Query: 4874 TLQQAQGFHSEIEDF 4888
LQ Q S + F
Sbjct: 6766 ALQGTQNPASPLPSF 6780
Score = 33.5 bits (75), Expect = 6.5
Identities = 40/204 (19%), Positives = 86/204 (42%), Gaps = 23/204 (11%)
Query: 1835 AELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKS 1894
+++Q++ + K L+ LK T + ++ + L+ ++ LQ
Sbjct: 6584 SDIQEIELRVKRLQEILKAFDTY---------KALVVSVNVSSKEFLQTESPESTELQSR 6634
Query: 1895 LSSVSDTWNSRLLHFQNAVEIEK---TKVLNQHTQLEGRLQDLRAWVGN-KNLILNSKGS 1950
L +S W + Q AV+ + + L Q Q+L W+ + KN + +
Sbjct: 6635 LRQLSLLWEAA----QGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNRRQKAHVT 6690
Query: 1951 NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDAL-AFDIQFFISEHAQDLSPQQNRQMLRL 2009
+ + D +L C ++ L++ + ER+ Q+D L I H +D + +
Sbjct: 6691 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEK----- 6745
Query: 2010 LNELQRSFQDILEQTAAQVDALQG 2033
++ +++ + + EQ + + ALQG
Sbjct: 6746 VHVIEKKLKQLREQVSQDLMALQG 6769
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 201 bits (511), Expect = 2e-50
Identities = 326/1644 (19%), Positives = 687/1644 (41%), Gaps = 106/1644 (6%)
Query: 3751 HDMEEINAR-------WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3803
HD++ I AR W L + + R +L+ L FQ+ L ++ W+ + + L+
Sbjct: 481 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 539
Query: 3804 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAE---LADREKITG 3860
+Q V+ +Q+ L++ + + V + A + A E D + I
Sbjct: 540 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 598
Query: 3861 QLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQ 3920
++ +E + EL AA R+ +LE+ L K F E AE + ++K+ +S+ G
Sbjct: 599 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAE--EEGWIREKEKILSSDDYGKD 656
Query: 3921 TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----LQA 3976
+ + + +H+A E+++ + QA+K G+ + AE+ SEKI ++
Sbjct: 657 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMI-----AEEHFGSEKIRERIIYIRE 711
Query: 3977 RYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFV--KDFKQDVLH 4034
+++ ++ + L++A S F D ++ W+ ++ +SS V ++ L
Sbjct: 712 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLV 770
Query: 4035 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTS 4094
++H D + EEI N + +D + AL ++ E ++ +L GI+ RY ++ +
Sbjct: 771 KKHKD---VAEEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELT 825
Query: 4095 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG-EQIPQFQQRQKELK 4153
+ L+ L F S + W+ E E+ L + Q P E + Q R + L+
Sbjct: 826 RLRKQALQDTLALYKMF-SEADACELWIDEKEQWL--NNMQIPEKLEDLEVIQHRFESLE 882
Query: 4154 KEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAA 4213
E+ + VN+++R L+ +E + N ++ + + ++ D + +A
Sbjct: 883 PEMNNQASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA 941
Query: 4214 IQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMD 4273
+ Q Y + +W+ E + + + + + A + D++ + +
Sbjct: 942 LS-IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1000
Query: 4274 ELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
+L ++ ++ + +L E + +E + R A L A L QF
Sbjct: 1001 DLQKEAEKLESEHPDQAQAILSRLAE-ISDVWEEMKTTLKNREASLGEASKL-QQFLRDL 1058
Query: 4334 EELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 4391
++ W+ T+ IA +P+ + E+L Q E ++ I ++ K+ +G +
Sbjct: 1059 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN---IKNEIDNYEEDYQKMRDMGEMV 1115
Query: 4392 KELNPEEGEM-VEEKYQKAENMYAQIKE--EVRQRALALDEAVSQSTQITEFHDKIEPML 4448
+ + M + ++ Q + + ++ + E RQ L+ A Q + T+ + E L
Sbjct: 1116 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTK---QAEAFL 1172
Query: 4449 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508
E + + MP + + I + ++ + A+ G L+
Sbjct: 1173 NNQEYVLAHTEMPTTL----EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLV----- 1223
Query: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD-- 4566
+D ++ + IQ+K+D + + A E ++ D +L +KF D L I +
Sbjct: 1224 SDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKM 1282
Query: 4567 --TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK 4624
QD+ +D E+ + +K Q AE + E L+ I G LI ETE
Sbjct: 1283 LTAQDMSYD-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA 1336
Query: 4625 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4684
V++ + ++ WE L T + + ++L DA +A + + + + WL ++ +
Sbjct: 1337 V-VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-D 1393
Query: 4685 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK--KATDETDRDIIREPLT 4742
G DL +V L + + + ++ ++ E+E+L Q + + + K+TDE D + T
Sbjct: 1394 DYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQ-T 1452
Query: 4743 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV 4802
+ L E L E R+H L A + QF +E+ + W+ L + + +
Sbjct: 1453 KFMELLEPLNE----RKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQT 1506
Query: 4803 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4862
+++ + K+ L+ ++ HQ ++ + + ++ S+ A ++R RL + Q W +++
Sbjct: 1507 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIE 1566
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4922
+TE+R ++L+ +AQ ++ + + ++ E + + + ++A L H L
Sbjct: 1567 ETEKRHRRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQIL 1624
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
++ ET +QL R ++ D + + +++ + + EER+ KL+
Sbjct: 1625 EQAVEDYAETVHQLSKTSRALV--ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1682
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV-NAHRD 5041
E L + + + W+ E + + Q E + FA + N ++
Sbjct: 1683 ERHRL-FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ-ERFREFARDTGNIGQE 1740
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 5101
++ ++ ++L S D I + W +++ R + L + + K +H
Sbjct: 1741 RVDTVNHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYH 1799
Query: 5102 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQ---KTLGGK-QPVYDTTIR 5157
+A K++ ++D L EL D + ++ H F+ + LG + + + + R
Sbjct: 1800 DA-KEIFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR 1856
Query: 5158 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
A +D QK +N EV + W ++ R+ +L + +F ++ L
Sbjct: 1857 LQAAYAGDK--ADDIQKREN---EVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDL 1910
Query: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277
+ W+ V Q+ E Q D+ V LM+ H+ + E+ R + G+ L+
Sbjct: 1911 MLWMEDVIRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKH 1969
Query: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
+ +K +L +L+ + + + L L+ + RD + WL E L
Sbjct: 1970 YASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRD-ASVAEAWLLGQEPYLS 2028
Query: 5338 FRGALPDDTEALQSLIDTHKEFMK 5361
R + + ++ LI H+ F K
Sbjct: 2029 SR-EIGQSVDEVEKLIKRHEAFEK 2051
Score = 171 bits (434), Expect = 2e-41
Identities = 326/1760 (18%), Positives = 699/1760 (39%), Gaps = 173/1760 (9%)
Query: 3783 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATV------ 3836
K++ LL W+ T ++ N+K ++ V + Q+Q + + K T
Sbjct: 293 KYESLASDLLEWIEQTIIILNNRKFANSLVGV-QQQLQAFNTYRTVEKPPKFTEKGNLEV 351
Query: 3837 ------DMLQAEGGRIAQSAE---LADREKITGQLESLESRWTELLSKAAARQKQLEDIL 3887
++A ++ E ++D K +LE E L RQ++LE
Sbjct: 352 LLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQ-- 409
Query: 3888 VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
LA++F A +LS ++ L + + G ++ +H+A+E DI + V
Sbjct: 410 -LARRFDRKAAMRETWLSENQR-LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA 467
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
V + + L + + + + K D++ + + + + L+ L ++F ++ +
Sbjct: 468 VVAVARELEAENYHDIKRITARK-DNVIRLWEYLLELLRARRQRLEMNLGLQKIF-QEML 525
Query: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK-------- 4059
+++W+ E+ K VL + + HL E+++ + V+ I
Sbjct: 526 YIMDWMDEM------------KVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRG 573
Query: 4060 -NGQALLKQTTGE-----EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 4113
N A T GE + +I++++ ++ Y ++ +++ LE++R+L F
Sbjct: 574 VNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWE 633
Query: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 4173
EE GW+RE E+ L++ + + + + + +HR D ++ S
Sbjct: 634 MAEE-EGWIREKEKILSSD-----------DYGKDLTSVMRLLSKHRAFEDEMSGRSGHF 681
Query: 4174 LELVPWRAREGLDKLVSD-------------ANEQYKLVSDTIGQRVDEIDAAIQRSQQY 4220
+ + +EG D + + EQ+ + R ++ A Q+
Sbjct: 682 EQAI----KEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQF 736
Query: 4221 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS 4280
+ AD AW+ + L + + D+ + Q V+K HKD +E+ ++R
Sbjct: 737 QADADDIDAWMLDI---LKIVSSSDVGHDEYSTQSLVKK--------HKDVAEEIANYRP 785
Query: 4281 EIFGTCGEEQKTVLQEKTES---------LIQQYEAISLLNSERYARLERAQVLVNQFWE 4331
+ T E+ + QE ES + ++Y+ ++ L R L+ L F E
Sbjct: 786 TL-DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 844
Query: 4332 TYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 4391
+ WI+E + + P E L Q L + + + +I QL
Sbjct: 845 A-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 902
Query: 4392 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
+ ++ + K ++Q +E V ++ AL A+S E ++ + E
Sbjct: 903 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 962
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
+ + S + + + R+ + +L ++ L++ E+L S+ D+
Sbjct: 963 KVIESTQDLGNDLAGVMALQRKLTGMER----DLVAIEAKLSDLQKEAEKL--ESEHPDQ 1016
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
A+ I +L ++ WE++K + RE + +L ++F D+ + + TQ +
Sbjct: 1017 ---AQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAI 1072
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4631
+ P K + E IK E D E+ + +R +G + + + +R+ +
Sbjct: 1073 ASEDMPNTLTEAEKLLTQH-ENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRL 1131
Query: 4632 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNT--VIKLCTMPPVGTD 4689
++ W L+K W+ R L + +DT QA +L+N V+ MP T
Sbjct: 1132 QALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA-FLNNQEYVLAHTEMP---TT 1187
Query: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749
L + + + ++F + + ++ + G ++ +DR I+E + +
Sbjct: 1188 LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR--IQEKVDSIDDRHR 1245
Query: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4809
E + +L+ L +F +EL W+ E++L AQ + + + + K
Sbjct: 1246 KNRETASELLMRLKDNR-DLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLK 1302
Query: 4810 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4869
H ++ +++ ++ + K G +L+ +A ++ +L +++ WE VL+ T + +
Sbjct: 1303 HQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLESTTQTKA 1360
Query: 4870 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4929
Q +A+ F D L +ESQ+ S G + L L +Q++ +
Sbjct: 1361 QRLFDANKAELFTQSCADLDKWLHGLESQIQ-SDDYGKDLTSVNILLKKQQMLENQMEVR 1419
Query: 4930 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLAT 4989
++ +L + + + + S + + ++ K+ + + ERK L + +
Sbjct: 1420 KKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH- 1475
Query: 4990 EFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQT 5049
+F +++ I W+ L ++ L TV I++++ E+ H+ +I ++ +
Sbjct: 1476 QFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1534
Query: 5050 GNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLID 5109
+ S I+ L ++ W +++ + +R R L++A RA+Q++ +
Sbjct: 1535 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQYYFDAAEAEA 1593
Query: 5110 WLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL-----KE 5164
W+ + E ++ SE + ++ + + L KH+ ++ + +T RAL E
Sbjct: 1594 WMSEQELYMMSEEKAKDEQSAVSM-LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPE 1652
Query: 5165 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 5224
+ K+D ++D + GK ER H+L Q + L W+ +
Sbjct: 1653 SERISMRQSKVDKLYAGLKDLAEERRGKLDER-HRLF-------QLNREVDDLEQWIAER 1704
Query: 5225 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG----KRTGTVQVLKRSGRELIENSRDDT 5280
E +A + D + V L + + F ++ G +R TV L ELI + D
Sbjct: 1705 EV-VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHL---ADELINSGHSDA 1760
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
+ L+ W + +L ++ L + + + + D + + ++ G
Sbjct: 1761 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG 1820
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
+ E LQ + T + ++ + + + A + A D I +
Sbjct: 1821 RDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDI----------Q 1870
Query: 5401 ARFEEVLTWAKQHQQRLETALSELVANAE------LLEELLAWIQWAETTLIQRDQEPIP 5454
R EVL K E+ LV + ++ +L+ W+ E + Q + + P
Sbjct: 1871 KRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWM---EDVIRQIEAQEKP 1927
Query: 5455 QNIDRVKALIAEHQTFMEEM 5474
+++ V+ L+ HQ E+
Sbjct: 1928 RDVSSVELLMNNHQGIKAEI 1947
Score = 162 bits (409), Expect = 1e-38
Identities = 282/1473 (19%), Positives = 612/1473 (41%), Gaps = 97/1473 (6%)
Query: 3756 INARWNTLNKKVAQRIAQLQEA-LLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3814
I +W L + A R +L+EA LLH +FQ + + +W+ D +++++ EY
Sbjct: 709 IREQWANLEQLSAIRKKRLEEASLLH--QFQADADDIDAWMLDILKIVSSSDVGHDEYST 766
Query: 3815 VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3874
++ +++ K + + + + T+D L + + Q E A+ + G+L +E R+ E+
Sbjct: 767 -QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ--EHAESPDVRGRLSGIEERYKEVAE 823
Query: 3875 KAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE-PVGTQTAKIQQQIIRHKA 3933
R++ L+D L L K F E A+ ++ E+ L N + P + ++ Q R ++
Sbjct: 824 LTRLRKQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQH--RFES 880
Query: 3934 LEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLD 3993
LE ++ N A+ V +I + L P+E+ + +++ D L R+S+ ++ RK L
Sbjct: 881 LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALL 939
Query: 3994 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV---------LHRQHADHLALN 4044
ALS E E +W+ E + S +D D+ L D +A+
Sbjct: 940 SALSIQNYHLECN-ETKSWIREKTKVIEST--QDLGNDLAGVMALQRKLTGMERDLVAIE 996
Query: 4045 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 4104
++ + +K ++ L+ ++ I +L I + ++ T +L +A
Sbjct: 997 AKLSDLQKEAEK--------LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA 1048
Query: 4105 RQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ---IPQFQQRQKELKKEVMEHRL 4161
+L +F ++ WL + +A+ + E + Q + + E+ +++
Sbjct: 1049 SKLQ-QFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQK 1107
Query: 4162 VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE 4221
+ D V++ + R+ L L + NE +K+ + Q + A Q+ +
Sbjct: 1108 MRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENR--QNLLSQSHAYQQFLRDT 1165
Query: 4222 QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 4281
+ A+A L + ++A + + A ++ Q+ F + +++ ++ +
Sbjct: 1166 KQAEAFL----NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRR 1221
Query: 4282 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 4341
+ G +QEK +S+ ++ SE RL+ + L +F + +ELS WI
Sbjct: 1222 LVSD-GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWIN 1279
Query: 4342 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 4401
E + L AQ S + L + + + +A +K +DK+ K G QL PE +
Sbjct: 1280 E-KMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV 1337
Query: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
V+EK M+ ++ + +A L +A +++ T+ ++ L LE+
Sbjct: 1338 VKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLES-------- 1388
Query: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD-LAAKEIQD 4520
+ D + ++ + + L+ E K+ EEL ++Q ++ + E+
Sbjct: 1389 ---QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1445
Query: 4521 KLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGID 4580
K + + ++ ER+ L E+ +F D+ + + + + + G +
Sbjct: 1446 KRLTVQTKFMELLEPLNERKHNLLASKEI-HQFNRDVEDEILWVGERMPLATSTDH-GHN 1503
Query: 4581 PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4640
++ ++ +T+++E G ++ I +++ +R+ + ++ W
Sbjct: 1504 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1563
Query: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD-QLNE 4699
L + ++R +LE+A +A Y D +A W+ + + + + + V + ++
Sbjct: 1564 LIEETEKRHRRLEEAHRAQQYYFDAAEAEA-WMSEQELYMMSEEKAKDEQSAVSMLKKHQ 1622
Query: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
+ E VE Y + + +L+ ++ + E++R +R+ +++ L+ L + R+
Sbjct: 1623 ILEQAVEDYAETVH--QLSKTSRALVADSHPESERISMRQ--SKVDKLYAGLKDLAEERR 1678
Query: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
KL+ L Q +++L W+ E + + V ++ ++
Sbjct: 1679 GKLDERH-RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1737
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Q V+TVN +EL+ +S DA+++ + +N+ W +L+ + R Q L ++ + +
Sbjct: 1738 GQERVDTVNHLADELI-NSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHK 1796
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT-HMELYSQLKAKEETYNQLL- 4937
+H E F R++ + G + E L H ++A QL
Sbjct: 1797 FYHDAKEIF----GRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE 1852
Query: 4938 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4997
D RL D + ++ L + W + E R+ +L + + F + +++
Sbjct: 1853 DAARLQAAYAGDKADDIQKRENEVL--EAWKSLLDACESRRVRLVDTGD-KFRFFSMVRD 1909
Query: 4998 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 5057
+ W+ + + P + + L + H+ E++A D + G L L+
Sbjct: 1910 LMLWMEDVIRQIEAQEKPRDVSSVELL-MNNHQGIKAEIDARNDSFTTCIELGKSL--LA 1966
Query: 5058 QKQDVVL-IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAES 5116
+K IK L+ + + ++++ + +R L + QF WL E
Sbjct: 1967 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQEP 2025
Query: 5117 HLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD-----TTI--------RTGRALK 5163
+L S EI D+++ + +H+ F+K+ + TT+ + K
Sbjct: 2026 YLSSR-EIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2084
Query: 5164 EKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 5196
+ PE S K+ E + +WDT G+ V +
Sbjct: 2085 RRPPSPEPSTKVSE-EAESQQQWDTSKGEQVSQ 2116
Score = 154 bits (389), Expect = 3e-36
Identities = 310/1641 (18%), Positives = 660/1641 (40%), Gaps = 214/1641 (13%)
Query: 2098 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 2157
Q+ ++ A F E ++ ENQ +S + A +++EA++ + ++
Sbjct: 404 QEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEE 463
Query: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
++ V A + E E K + K + L +++ + + Q L G++++
Sbjct: 464 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 523
Query: 2218 SL-------EKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270
L E L + Y E L ++ +++A ++ Q + SAQ
Sbjct: 524 MLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEA---DIGIQAERVRGVNASAQK 580
Query: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFE 2330
F G P + Q+++ ++ ++ Y L Q AE + L KF + E E
Sbjct: 581 FATD-GEGYKPCDPQVIRDRVAHMEFCYQ-ELCQLAAERRARLEESRRLWKFFWEMAEEE 638
Query: 2331 SWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 2390
W+ EK L + G ++ LL + +F +++ G E +
Sbjct: 639 GWIREKEKILSS-DDYGKDLTSVMRLLSKHRAFEDEMSGRSG-------------HFEQA 684
Query: 2391 FKEGKEPSEIGNLVKDKLKDA----------TERYTALHSKCTRLGSHLNMLLGQYHQFQ 2440
KEG++ + +K+++ E+ +A+ K S L HQFQ
Sbjct: 685 IKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLL-------HQFQ 737
Query: 2441 NSADSLQAWMQACEANVEKLLSDT-VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKV 2499
AD + AWM ++ K++S + V D Q + K + EE+A ++ ++ L +
Sbjct: 738 ADADDIDAWM----LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 793
Query: 2500 ARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESL 2559
A + + E +PD V+ I ++ ++ R LQ +A + E+ ++
Sbjct: 794 ASALPQEHAE-SPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DAC 848
Query: 2560 LQSIGEVEQNLEGKQVSSLSSG--VIQEALATNMKLKQDIARQKSSLEATREMVTRFMET 2617
I E EQ L Q+ VIQ + L+ ++ Q S + ++ + M +
Sbjct: 849 ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES---LEPEMNNQASRVAVVNQIARQLMHS 905
Query: 2618 ADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENK 2675
+ + Q KL +F +L ++K++ L L Q E + + ++ K
Sbjct: 906 GHPSEKEIKAQQDKLNTRWSQFRELV--DRKKDALLSALSIQNYHLE--CNETKSWIREK 961
Query: 2676 SRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR 2735
++++ S QD+ + + L ++ + +L +E +++L L+ +H D+
Sbjct: 962 TKVIES----TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLE-SEHPDQ 1016
Query: 2736 VQ-------NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT 2788
Q + + E++ T+K RE +L +F + + FQ WL T+ +I
Sbjct: 1017 AQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLSRTQTAIASE 1075
Query: 2789 ETSMSAKELEK---QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2845
+ + E EK Q E++K+ +D++ EE K + ++ +QG+T
Sbjct: 1076 DMPNTLTEAEKLLTQHENIKNEIDNY-------EEDYQKMRDMGEMV-------TQGQTD 1121
Query: 2846 SILPSVGSSVGSVN-GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE 2904
+ + + +++ G++ + E + ++ + Y++ L + +++ +A LN E
Sbjct: 1122 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQF---LRDTKQA-EAFLNNQEY 1177
Query: 2905 V--HKEANSVLQWLES----KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958
V H E + L+ E+ +E+ + +MDA E + A E+ + +++ NS +
Sbjct: 1178 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDA-----NEEKINAVVETGRRLVSDGNINSDR 1232
Query: 2959 IQ-----------KVKEALAGLLVTYPNSQEAENWKKIQEEL----NSRWERATEVTVAR 3003
IQ K +E + LL+ ++++ + + + +EL N + A +++
Sbjct: 1233 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDE 1292
Query: 3004 QRQLEESASHLACFQAAESQLRPWL--MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKE 3061
R L F A + + WL +EKE M L ++K + + ++KE
Sbjct: 1293 ARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM------------QLISEKPETEAVVKE 1340
Query: 3062 -FEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 3120
+ E L Q D + + + Q +L L+ SQI
Sbjct: 1341 KLTGLHKMWEVLESTTQTKAQRLFDAN--------KAELFTQSCADLDKWLHGLESQIQS 1392
Query: 3121 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180
D + + +V L Q + Q E K+++E E++S + L E
Sbjct: 1393 ------------DDYGKDLTSVNILLKKQQMLENQMEVRKKEIE---ELQSQAQALSQEG 1437
Query: 3181 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 3240
K DE+ KRL ++ LE L + N L A QF +
Sbjct: 1438 KST----DEVD------------SKRLTVQTKFMELLEPLNERKHNLL--ASKEIHQFNR 1479
Query: 3241 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 3300
++ W+ ++ A + L+ +Q +++N+ QK + H + I +++
Sbjct: 1480 DVEDEILWVGERM-PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1538
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
+ ++ +L +LK W L ++T R RL++ +AQ+Y + + W+
Sbjct: 1539 VTD-SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-HRAQQYYFDAAEAEAWMS 1596
Query: 3361 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 3420
+ + M D S L + + + VE + L+ + L+ S + + I
Sbjct: 1597 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1656
Query: 3421 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 3480
++ +++ + + + + G L+E R R FQ + ++V+ + + + +
Sbjct: 1657 SMRQSKVDKLYAGLKDLAEERRGKLDE---RHRLFQ-----LNREVDDLEQWIAEREVVA 1708
Query: 3481 SQACSNKNLEKLRAQQEVLQAL--------EPQVDYLRNFTQGLVEDAPDGSDASQLLHQ 3532
++ E + QE + + +VD + + L+ SDA+ +
Sbjct: 1709 GSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG--HSDAATIAEW 1766
Query: 3533 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3592
+ + + ++ + +++ ++ E + +F+ +E+F ++ D +L +GRD
Sbjct: 1767 KDGLNEAWADLLELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLP--EELGRDQ 1823
Query: 3593 DSLQSQIEDVRLFLNKIH-VLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3651
+++++ L ++H + DI+A + R + E+ L + + + K+ +
Sbjct: 1824 NTVET--------LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1875
Query: 3652 LTERGKARQEQLELTLGRVED 3672
+ E K+ + E R+ D
Sbjct: 1876 VLEAWKSLLDACESRRVRLVD 1896
Score = 147 bits (371), Expect = 3e-34
Identities = 312/1712 (18%), Positives = 703/1712 (41%), Gaps = 146/1712 (8%)
Query: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
+SD+N +E+L HER+ +L+ L R E++ + A + +E L + S
Sbjct: 376 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 435
Query: 2934 K----TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI---- 2985
V+A + ++A ++ ++Q V V EAEN+ I
Sbjct: 436 NFGFDLPAVEAATKKHEAIETDIAAYEERVQAV--------VAVARELEAENYHDIKRIT 487
Query: 2986 --QEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043
++ + WE E+ AR+++LE + FQ + W+ E ++++ LS
Sbjct: 488 ARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEM-LYIMDWMDEMKVLV-----LSQ 541
Query: 3044 D--PNMLNAQKQQVQFMLKEFE--ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQ 3098
D ++L + + L E + + ++ +N +AQ T G G ++ +
Sbjct: 542 DYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVA 601
Query: 3099 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA------I 3152
+ + EL R +++++ S + + +++E+ + ++ + S+ +
Sbjct: 602 HMEFCYQELCQLAAERRARLEE----SRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 657
Query: 3153 STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 3212
++ + + E+ + +KE + + E E + +++++R+ +
Sbjct: 658 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE------EHFGSEKIRERIIYIRE 711
Query: 3213 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 3272
LE L+A R RL+ A + QFQ D++ W+ D + + + QS
Sbjct: 712 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSL 769
Query: 3273 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKK 3330
++++++ + + + + + + + +L P E E ++ +L ++ ++E+++
Sbjct: 770 VKKHKDVAEEIANYRPTLDTLHEQASAL-----PQEHAESPDVRGRLSGIEERYKEVAEL 824
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
T R+ L+D + + + + WI++ + ++ +++ LE R +++
Sbjct: 825 TRLRKQALQDTLALYKMFS-EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEP 883
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 3450
E+ + S + ++N A L++S E I+ ++ +N E + K +L
Sbjct: 884 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS 943
Query: 3451 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE-KLRAQQEVLQALEPQVDYL 3509
++ + + + +E LG+ L+ KL + L A+E ++ L
Sbjct: 944 -IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1002
Query: 3510 RNFTQGLVEDAPDGSDA--SQLLHQAEVAQQEFLEVKQRVNS--GCVMMENKLEGIGQFH 3565
+ + L + PD + A S+L ++V ++ +K R S ++ L + F
Sbjct: 1003 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1062
Query: 3566 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRH 3625
+ + +A D M + + L +Q E+++ N+I + D +
Sbjct: 1063 SWLSRTQTAIASED-----MPNTLTEAEKLLTQHENIK---NEIDNYEEDYQKMRDMGEM 1114
Query: 3626 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LN 3681
+ + + + L++ L+AL+ +L + + RQ L + + F R K LN
Sbjct: 1115 VTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLN 1173
Query: 3682 DATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAG 3741
+ E + G E I Q+ DF +D + K+ V G+ L+
Sbjct: 1174 NQEYVLAHTEMPTTLEGAEAAIKKQE--DF----MTTMDANEEKINAVVETGRRLVSDGN 1227
Query: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEEL 3801
+ D ++ ++ I+ R + N++ A + + KF + L W+ E++
Sbjct: 1228 INSD--RIQEKVDSIDDR-HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKM 1282
Query: 3802 IANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ---SAELADREKI 3858
+ Q E + + ++ + + L K +D ++ EG ++ E +EK+
Sbjct: 1283 LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKL 1342
Query: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
TG L W L S + ++L D A+ F ++ + +L E ++ S+ G
Sbjct: 1343 TG----LHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLHGLESQI-QSDDYG 1396
Query: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----L 3974
+ + + + LE +E ++ + Q+LS ++G ++++DS +
Sbjct: 1397 KDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS------QEGKSTDEVDSKRLTV 1450
Query: 3975 QARYSEIQDRCC-RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVL 4033
Q ++ E+ + RK LL A F D + + W+ E L++ +
Sbjct: 1451 QTKFMELLEPLNERKHNLL--ASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTV 1507
Query: 4034 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 4093
+ L +EI + +D + Q ++ ++ I+++L +K + +
Sbjct: 1508 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1567
Query: 4094 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELK 4153
+ K R LE+A + A ++ E W+ E+EL + EQ ++ ++
Sbjct: 1568 TEKRHRRLEEAHR-AQQYYFDAAEAEAWMS--EQELYMMSEEKAKDEQSAVSMLKKHQIL 1624
Query: 4154 KEVMEHRLVLDTVNEVSRALLELV--PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
++ +E +TV+++S+ LV E + S ++ Y + D +R ++D
Sbjct: 1625 EQAVED--YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1682
Query: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-QTTAQLQVQ-KAFSIDIIRHK 4269
+ Q + D E W+AE R+++A G L QD + LQ + + F+ D
Sbjct: 1683 ERHRLFQLNREVDDLE-QWIAE--REVVA-GSHELGQDYEHVTMLQERFREFARDTGNIG 1738
Query: 4270 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 4329
+ +H ++ G + E + L + + + L R ++ A +++F
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR-TQILAASYELHKF 1797
Query: 4330 WETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 4389
+ +E+ I++ +LP E+L + Q + L+ H + +G
Sbjct: 1798 YHDAKEIFGRIQDKH---KKLP------EELGRDQNTVETLQRM---HTTFEHDIQALGT 1845
Query: 4390 QLKELNPEEGEMVEEKY--QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK---- 4443
Q+++L E+ ++ Y KA+++ + E + LD S+ ++ + DK
Sbjct: 1846 QVRQLQ-EDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1904
Query: 4444 --IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 4501
+ ++ +E++ ++ P +V + +++++ E++ SF G+
Sbjct: 1905 SMVRDLMLWMEDVIRQIEAQEK-PRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKS 1963
Query: 4502 LIGRSQGADKDLAAKEIQ--DKLDQMVFFWED 4531
L+ R A +++ K +Q +K +M+ WED
Sbjct: 1964 LLARKHYASEEIKEKLLQLTEKRKEMIDKWED 1995
Score = 139 bits (350), Expect = 8e-32
Identities = 255/1435 (17%), Positives = 560/1435 (39%), Gaps = 152/1435 (10%)
Query: 4204 GQRVDEI-DAAIQRS---QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 4259
G+R+ ++ D AI+ ++YE A L W+ +T ++ L + Q Q+Q
Sbjct: 274 GKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQA 330
Query: 4260 AFSIDIIRHKDSMDE-------LFSHRSEIFGTCGEEQKTVLQEKTE---SLIQQYEAIS 4309
+ + E LF+ +S++ QK + + + + + +E +
Sbjct: 331 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRAN---NQKVYMPREGKLISDINKAWERLE 387
Query: 4310 LLNSER-------YARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQ 4362
ER R E+ + L +F W+ E + L++Q + D +
Sbjct: 388 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQ-DNFGFDLPAVEA 446
Query: 4363 QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
++ + IA ++ + ++ + +L+ N + + + + ++ + E +R
Sbjct: 447 ATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRA 506
Query: 4423 RA------LALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECIS 4476
R L L + + I ++ D+++ ++ + + L + L+
Sbjct: 507 RRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLL------------ 554
Query: 4477 DNKSATVELEKLQPSFEALKRRGEELIGRSQGAD----KDLAAKEIQDKLDQMVFFWEDI 4532
K VE + +A + RG + D K + I+D++ M F ++++
Sbjct: 555 -QKHTLVEADI---GIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 610
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
A ER + + L + FW +MA I++ + I+ + G D + + + +
Sbjct: 611 CQLAAERRARLEESRRLWKFFW-EMAEEEGWIREKEKILSS-DDYGKDLTSVMRLLSKHR 668
Query: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652
++E G E G D+I A ++R+ I + W NL + R ++L
Sbjct: 669 AFEDEMSGRSGHFEQAIKEGEDMI-AEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRL 727
Query: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4712
E+A Q+Q + W+ + ++K+ + VG D + + + + K+ E+ +
Sbjct: 728 EEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 785
Query: 4713 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
++ L+ Q + ++ + D +R L+ ++ ++ + E R+ L+ L F
Sbjct: 786 TLDTLHEQASALPQEHAESPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF 842
Query: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHV--LKNDVLAHQATVETVNKA 4830
A + W+ E+ L+ + K+ ++E+ +H L+ ++ + V VN+
Sbjct: 843 SEA-DACELWIDEKEQWLNNMQI---PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQI 898
Query: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH---SEIED 4887
+L+ S + ++++ + +N W + + ++ L S L Q +H +E +
Sbjct: 899 ARQLMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETKS 956
Query: 4888 FLLELTRM-ESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4946
++ E T++ ES G+ R+ +L + ++AK + +K L
Sbjct: 957 WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVA-IEAKLSDLQKEAEK-----LE 1010
Query: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
+ +A + W + + ++ R++ L EA L +F L +F +WL+ +
Sbjct: 1011 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ-QFLRDLDDFQSWLSRTQ 1069
Query: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
++ P+ L + +H+ NE++ + + ++ G + + ++
Sbjct: 1070 TAIASEDMPNT-LTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1128
Query: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
L ++ + W ++ + E ++L +QF K+ +L + E L + E+
Sbjct: 1129 QRLQALDTGWNEL-HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPT 1186
Query: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 5186
+ + + K ++F T+ + + + TGR L + D +++K
Sbjct: 1187 TLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSD---------RIQEKV 1237
Query: 5187 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDW----LYKVEPQLAEDQPVHGDLDLVM 5242
D++ + + + E L+ D + L D L+ E L + + +
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1297
Query: 5243 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 5302
+ H+ F EL + +++ G +LI + VK +L L W+ + +
Sbjct: 1298 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1357
Query: 5303 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-----LQSLIDTHK 5357
+K RL A K AE+F + L +WL E ++ D T Q +++
Sbjct: 1358 TKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQM 1416
Query: 5358 EFMKK-VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQR 5416
E KK +EE + + G+ + ++ +F E+L + +
Sbjct: 1417 EVRKKEIEELQSQAQALSQEGK---------STDEVDSKRLTVQTKFMELLEPLNERKHN 1467
Query: 5417 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476
L + N ++ +E+L W + N+ V+ LI ++QT +E+
Sbjct: 1468 LLASKEIHQFNRDVEDEIL----WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1523
Query: 5477 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQL 5536
QP +D + + + +NI + S I Q
Sbjct: 1524 HQPRIDDIFE--RSQNI----------------------------VTDSSSLSAEAIRQR 1553
Query: 5537 SARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVM 5591
A +Q+W L +E K + RLEE + FD + WM+ ++ +M
Sbjct: 1554 LADLKQLWGLLIEETEKRH---RRLEEAHRAQQYYFDAAEAE--AWMSEQELYMM 1603
Score = 99.0 bits (245), Expect = 1e-19
Identities = 258/1413 (18%), Positives = 529/1413 (37%), Gaps = 210/1413 (14%)
Query: 1817 LRNIEMRTKQIQPL-ELNLAELQDLL-----------CQAKVLERE-----------LKD 1853
L IE R K++ L L LQD L C+ + E+E L+D
Sbjct: 811 LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED 870
Query: 1854 LTTLVSQELECVNQIIISQPQEVPA--QLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQN 1911
L ++ E + + +Q V Q+ + L +K + + D N+R F+
Sbjct: 871 LE-VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE 929
Query: 1912 AVEIEKTKVLN----QHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYE 1967
V+ +K +L+ Q+ LE + ++W+ K ++ S D+ + ++
Sbjct: 930 LVDRKKDALLSALSIQNYHLE--CNETKSWIREKTKVIESTQDLGN-DLAGVMALQRKLT 986
Query: 1968 DLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQ 2027
+++ + +A+L L + + SEH P Q + +L L E+ +++ ++ T
Sbjct: 987 GMERDLVAIEAKLSDLQKEAEKLESEH-----PDQAQAILSRLAEISDVWEE-MKTTLKN 1040
Query: 2028 VDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSAL 2087
+A G +++Q + L+D SW+ + + A+A T L+
Sbjct: 1041 REASLGEASKLQQFL-------------RDLDDFQSWLSRTQTAIASEDMPNT---LTEA 1084
Query: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
+K + ++++++I N + ++D+ + + QT + LR++L +
Sbjct: 1085 EKLLTQHENIKNEIDNYEEDYQK-MRDMGEMVTQGQT---DAQYMFLRQRLQALDTGWNE 1140
Query: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQL--- 2204
L + Q L + + A QQ +K A+ N++ + A + T++ + +
Sbjct: 1141 LHKMWENRQNLLSQ--SHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1198
Query: 2205 ---LTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNF 2261
+T + E+ A +E G +DG + ++ EK+D
Sbjct: 1199 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVD-------------------- 1238
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK 2321
+ D+H N ++ + L LK+ +LQK
Sbjct: 1239 --------SIDDRHRKN-----RETASELLMRLKD-------------------NRDLQK 1266
Query: 2322 FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 2381
FLQD +E W+ +EK L L S + +F ++ S+K L + G
Sbjct: 1267 FLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG 1324
Query: 2382 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 2441
+++ E E +VK+KL + + L S T+ + + F
Sbjct: 1325 MQLI---------SEKPETEAVVKEKLTGLHKMWEVLES-TTQTKAQRLFDANKAELFTQ 1374
Query: 2442 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 2501
S L W+ E+ ++ SD D + L + L+ ++ + +E+LQ A+
Sbjct: 1375 SCADLDKWLHGLESQIQ---SDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQ 1431
Query: 2502 DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQ 2561
+ + EG+ + V ++ + F L L ER L A + +E +
Sbjct: 1432 ALSQ-EGKSTDE---VDSKRLTVQTKFMELLEPLNERKHNL-LASKEIHQFNRDVEDEIL 1486
Query: 2562 SIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADST 2621
+GE L + +Q + N L+++I + ++ E + + S
Sbjct: 1487 WVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSL 1545
Query: 2622 TAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2681
+A ++ +LA++ Q + L +++ EK + +A+ + + + + +M + + S
Sbjct: 1546 SAEAIRQRLADLKQLW-GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMS 1604
Query: 2682 GN--QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQD----- 2734
+ +Q ++ Q L +ED E V +LS AL H +
Sbjct: 1605 EEKAKDEQSAVSMLKKHQILEQAVEDYAET-------VHQLSKTSRALVADSHPESERIS 1657
Query: 2735 -RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMS 2793
R + K + L+ +ER + +L + + V ++W+ E E E
Sbjct: 1658 MRQSKVDKLYAGLKDLAEERRGKLDE-RHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1716
Query: 2794 AKELEKQIEHLKSLLDDWASKG-TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVG 2852
+ + E + D + G V+ +N L N A ++ K G
Sbjct: 1717 YEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL------ 1770
Query: 2853 SSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
DL E + D + LH+ + I R+++ HK+
Sbjct: 1771 --------NEAWADLLE----LIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEE 1818
Query: 2913 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2972
L ++ E L+ M + F +++ ++++++E A L
Sbjct: 1819 LGRDQNTVETLQRM------------------HTTFEHDIQALGTQVRQLQEDAARLQAA 1860
Query: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
Y +A++ +K + E+ W+ + +R+ +L ++ F L W ME
Sbjct: 1861 YA-GDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR-DLMLW-MEDV 1917
Query: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 3092
+ D + + Q + E +AR E + +L ++ +
Sbjct: 1918 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK---HYASEE 1974
Query: 3093 VQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE---------LLQDLSEKVRAVG 3143
++++L + +K E+ DK R + + I++ Q+ L Q+ R +G
Sbjct: 1975 IKEKLLQLTEKRKEMIDKWEDRWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIG 2033
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL 3176
Q + + + EA ++ E S LE+L
Sbjct: 2034 QSVDEVEKLIKRHEAFEKSAATWDERFSALERL 2066
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 201 bits (511), Expect = 2e-50
Identities = 326/1644 (19%), Positives = 687/1644 (41%), Gaps = 106/1644 (6%)
Query: 3751 HDMEEINAR-------WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3803
HD++ I AR W L + + R +L+ L FQ+ L ++ W+ + + L+
Sbjct: 494 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 552
Query: 3804 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAE---LADREKITG 3860
+Q V+ +Q+ L++ + + V + A + A E D + I
Sbjct: 553 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 611
Query: 3861 QLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQ 3920
++ +E + EL AA R+ +LE+ L K F E AE + ++K+ +S+ G
Sbjct: 612 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAE--EEGWIREKEKILSSDDYGKD 669
Query: 3921 TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----LQA 3976
+ + + +H+A E+++ + QA+K G+ + AE+ SEKI ++
Sbjct: 670 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMI-----AEEHFGSEKIRERIIYIRE 724
Query: 3977 RYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFV--KDFKQDVLH 4034
+++ ++ + L++A S F D ++ W+ ++ +SS V ++ L
Sbjct: 725 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLV 783
Query: 4035 RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTS 4094
++H D + EEI N + +D + AL ++ E ++ +L GI+ RY ++ +
Sbjct: 784 KKHKD---VAEEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELT 838
Query: 4095 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG-EQIPQFQQRQKELK 4153
+ L+ L F S + W+ E E+ L + Q P E + Q R + L+
Sbjct: 839 RLRKQALQDTLALYKMF-SEADACELWIDEKEQWL--NNMQIPEKLEDLEVIQHRFESLE 895
Query: 4154 KEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAA 4213
E+ + VN+++R L+ +E + N ++ + + ++ D + +A
Sbjct: 896 PEMNNQASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA 954
Query: 4214 IQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMD 4273
+ Q Y + +W+ E + + + + + A + D++ + +
Sbjct: 955 LS-IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1013
Query: 4274 ELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
+L ++ ++ + +L E + +E + R A L A L QF
Sbjct: 1014 DLQKEAEKLESEHPDQAQAILSRLAE-ISDVWEEMKTTLKNREASLGEASKL-QQFLRDL 1071
Query: 4334 EELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 4391
++ W+ T+ IA +P+ + E+L Q E ++ I ++ K+ +G +
Sbjct: 1072 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHEN---IKNEIDNYEEDYQKMRDMGEMV 1128
Query: 4392 KELNPEEGEM-VEEKYQKAENMYAQIKE--EVRQRALALDEAVSQSTQITEFHDKIEPML 4448
+ + M + ++ Q + + ++ + E RQ L+ A Q + T+ + E L
Sbjct: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTK---QAEAFL 1185
Query: 4449 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508
E + + MP + + I + ++ + A+ G L+
Sbjct: 1186 NNQEYVLAHTEMPTTL----EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLV----- 1236
Query: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD-- 4566
+D ++ + IQ+K+D + + A E ++ D +L +KF D L I +
Sbjct: 1237 SDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKM 1295
Query: 4567 --TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEK 4624
QD+ +D E+ + +K Q AE + E L+ I G LI ETE
Sbjct: 1296 LTAQDMSYD-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA 1349
Query: 4625 PEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP 4684
V++ + ++ WE L T + + ++L DA +A + + + + WL ++ +
Sbjct: 1350 V-VKEKLTGLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-D 1406
Query: 4685 PVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK--KATDETDRDIIREPLT 4742
G DL +V L + + + ++ ++ E+E+L Q + + + K+TDE D + T
Sbjct: 1407 DYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQ-T 1465
Query: 4743 ELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKV 4802
+ L E L E R+H L A + QF +E+ + W+ L + + +
Sbjct: 1466 KFMELLEPLNE----RKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQT 1519
Query: 4803 IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQ 4862
+++ + K+ L+ ++ HQ ++ + + ++ S+ A ++R RL + Q W +++
Sbjct: 1520 VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIE 1579
Query: 4863 KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMEL 4922
+TE+R ++L+ +AQ ++ + + ++ E + + + ++A L H L
Sbjct: 1580 ETEKRHRRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQIL 1637
Query: 4923 YSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE 4982
++ ET +QL R ++ D + + +++ + + EER+ KL+
Sbjct: 1638 EQAVEDYAETVHQLSKTSRALV--ADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1695
Query: 4983 EALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV-NAHRD 5041
E L + + + W+ E + + Q E + FA + N ++
Sbjct: 1696 ERHRL-FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ-ERFREFARDTGNIGQE 1753
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 5101
++ ++ ++L S D I + W +++ R + L + + K +H
Sbjct: 1754 RVDTVNHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYH 1812
Query: 5102 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQ---KTLGGK-QPVYDTTIR 5157
+A K++ ++D L EL D + ++ H F+ + LG + + + + R
Sbjct: 1813 DA-KEIFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR 1869
Query: 5158 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
A +D QK +N EV + W ++ R+ +L + +F ++ L
Sbjct: 1870 LQAAYAGDK--ADDIQKREN---EVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDL 1923
Query: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277
+ W+ V Q+ E Q D+ V LM+ H+ + E+ R + G+ L+
Sbjct: 1924 MLWMEDVIRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKH 1982
Query: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
+ +K +L +L+ + + + L L+ + RD + WL E L
Sbjct: 1983 YASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRD-ASVAEAWLLGQEPYLS 2041
Query: 5338 FRGALPDDTEALQSLIDTHKEFMK 5361
R + + ++ LI H+ F K
Sbjct: 2042 SR-EIGQSVDEVEKLIKRHEAFEK 2064
Score = 171 bits (434), Expect = 2e-41
Identities = 326/1760 (18%), Positives = 699/1760 (39%), Gaps = 173/1760 (9%)
Query: 3783 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATV------ 3836
K++ LL W+ T ++ N+K ++ V + Q+Q + + K T
Sbjct: 306 KYESLASDLLEWIEQTIIILNNRKFANSLVGV-QQQLQAFNTYRTVEKPPKFTEKGNLEV 364
Query: 3837 ------DMLQAEGGRIAQSAE---LADREKITGQLESLESRWTELLSKAAARQKQLEDIL 3887
++A ++ E ++D K +LE E L RQ++LE
Sbjct: 365 LLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQ-- 422
Query: 3888 VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
LA++F A +LS ++ L + + G ++ +H+A+E DI + V
Sbjct: 423 -LARRFDRKAAMRETWLSENQR-LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA 480
Query: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
V + + L + + + + K D++ + + + + L+ L ++F ++ +
Sbjct: 481 VVAVARELEAENYHDIKRITARK-DNVIRLWEYLLELLRARRQRLEMNLGLQKIF-QEML 538
Query: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK-------- 4059
+++W+ E+ K VL + + HL E+++ + V+ I
Sbjct: 539 YIMDWMDEM------------KVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRG 586
Query: 4060 -NGQALLKQTTGE-----EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 4113
N A T GE + +I++++ ++ Y ++ +++ LE++R+L F
Sbjct: 587 VNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWE 646
Query: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 4173
EE GW+RE E+ L++ + + + + + +HR D ++ S
Sbjct: 647 MAEE-EGWIREKEKILSSD-----------DYGKDLTSVMRLLSKHRAFEDEMSGRSGHF 694
Query: 4174 LELVPWRAREGLDKLVSD-------------ANEQYKLVSDTIGQRVDEIDAAIQRSQQY 4220
+ + +EG D + + EQ+ + R ++ A Q+
Sbjct: 695 EQAI----KEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQF 749
Query: 4221 EQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRS 4280
+ AD AW+ + L + + D+ + Q V+K HKD +E+ ++R
Sbjct: 750 QADADDIDAWMLDI---LKIVSSSDVGHDEYSTQSLVKK--------HKDVAEEIANYRP 798
Query: 4281 EIFGTCGEEQKTVLQEKTES---------LIQQYEAISLLNSERYARLERAQVLVNQFWE 4331
+ T E+ + QE ES + ++Y+ ++ L R L+ L F E
Sbjct: 799 TL-DTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
Query: 4332 TYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 4391
+ WI+E + + P E L Q L + + + +I QL
Sbjct: 858 A-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 915
Query: 4392 KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 4451
+ ++ + K ++Q +E V ++ AL A+S E ++ + E
Sbjct: 916 MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 975
Query: 4452 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4511
+ + S + + + R+ + +L ++ L++ E+L S+ D+
Sbjct: 976 KVIESTQDLGNDLAGVMALQRKLTGMER----DLVAIEAKLSDLQKEAEKL--ESEHPDQ 1029
Query: 4512 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIV 4571
A+ I +L ++ WE++K + RE + +L ++F D+ + + TQ +
Sbjct: 1030 ---AQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAI 1085
Query: 4572 HDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4631
+ P K + E IK E D E+ + +R +G + + + +R+ +
Sbjct: 1086 ASEDMPNTLTEAEKLLTQH-ENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRL 1144
Query: 4632 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNT--VIKLCTMPPVGTD 4689
++ W L+K W+ R L + +DT QA +L+N V+ MP T
Sbjct: 1145 QALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA-FLNNQEYVLAHTEMP---TT 1200
Query: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749
L + + + ++F + + ++ + G ++ +DR I+E + +
Sbjct: 1201 LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR--IQEKVDSIDDRHR 1258
Query: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4809
E + +L+ L +F +EL W+ E++L AQ + + + + K
Sbjct: 1259 KNRETASELLMRLKDNR-DLQKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLK 1315
Query: 4810 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4869
H ++ +++ ++ + K G +L+ +A ++ +L +++ WE VL+ T + +
Sbjct: 1316 HQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLESTTQTKA 1373
Query: 4870 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4929
Q +A+ F D L +ESQ+ S G + L L +Q++ +
Sbjct: 1374 QRLFDANKAELFTQSCADLDKWLHGLESQIQ-SDDYGKDLTSVNILLKKQQMLENQMEVR 1432
Query: 4930 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLAT 4989
++ +L + + + + S + + ++ K+ + + ERK L + +
Sbjct: 1433 KKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIH- 1488
Query: 4990 EFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQT 5049
+F +++ I W+ L ++ L TV I++++ E+ H+ +I ++ +
Sbjct: 1489 QFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFER 1547
Query: 5050 GNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLID 5109
+ S I+ L ++ W +++ + +R R L++A RA+Q++ +
Sbjct: 1548 SQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQYYFDAAEAEA 1606
Query: 5110 WLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL-----KE 5164
W+ + E ++ SE + ++ + + L KH+ ++ + +T RAL E
Sbjct: 1607 WMSEQELYMMSEEKAKDEQSAVSM-LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPE 1665
Query: 5165 KTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKV 5224
+ K+D ++D + GK ER H+L Q + L W+ +
Sbjct: 1666 SERISMRQSKVDKLYAGLKDLAEERRGKLDER-HRLF-------QLNREVDDLEQWIAER 1717
Query: 5225 EPQLAEDQPVHGDLDLVMNLMDAHKVFQKELG----KRTGTVQVLKRSGRELIENSRDDT 5280
E +A + D + V L + + F ++ G +R TV L ELI + D
Sbjct: 1718 EV-VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHL---ADELINSGHSDA 1773
Query: 5281 TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRG 5340
+ L+ W + +L ++ L + + + + D + + ++ G
Sbjct: 1774 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG 1833
Query: 5341 ALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIR 5400
+ E LQ + T + ++ + + + A + A D I +
Sbjct: 1834 RDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDI----------Q 1883
Query: 5401 ARFEEVLTWAKQHQQRLETALSELVANAE------LLEELLAWIQWAETTLIQRDQEPIP 5454
R EVL K E+ LV + ++ +L+ W+ E + Q + + P
Sbjct: 1884 KRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWM---EDVIRQIEAQEKP 1940
Query: 5455 QNIDRVKALIAEHQTFMEEM 5474
+++ V+ L+ HQ E+
Sbjct: 1941 RDVSSVELLMNNHQGIKAEI 1960
Score = 162 bits (409), Expect = 1e-38
Identities = 282/1473 (19%), Positives = 612/1473 (41%), Gaps = 97/1473 (6%)
Query: 3756 INARWNTLNKKVAQRIAQLQEA-LLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3814
I +W L + A R +L+EA LLH +FQ + + +W+ D +++++ EY
Sbjct: 722 IREQWANLEQLSAIRKKRLEEASLLH--QFQADADDIDAWMLDILKIVSSSDVGHDEYST 779
Query: 3815 VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLS 3874
++ +++ K + + + + T+D L + + Q E A+ + G+L +E R+ E+
Sbjct: 780 -QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ--EHAESPDVRGRLSGIEERYKEVAE 836
Query: 3875 KAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSE-PVGTQTAKIQQQIIRHKA 3933
R++ L+D L L K F E A+ ++ E+ L N + P + ++ Q R ++
Sbjct: 837 LTRLRKQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQH--RFES 893
Query: 3934 LEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLD 3993
LE ++ N A+ V +I + L P+E+ + +++ D L R+S+ ++ RK L
Sbjct: 894 LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ-DKLNTRWSQFRELVDRKKDALL 952
Query: 3994 QALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV---------LHRQHADHLALN 4044
ALS E E +W+ E + S +D D+ L D +A+
Sbjct: 953 SALSIQNYHLECN-ETKSWIREKTKVIEST--QDLGNDLAGVMALQRKLTGMERDLVAIE 1009
Query: 4045 EEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA 4104
++ + +K ++ L+ ++ I +L I + ++ T +L +A
Sbjct: 1010 AKLSDLQKEAEK--------LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA 1061
Query: 4105 RQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ---IPQFQQRQKELKKEVMEHRL 4161
+L +F ++ WL + +A+ + E + Q + + E+ +++
Sbjct: 1062 SKLQ-QFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQK 1120
Query: 4162 VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE 4221
+ D V++ + R+ L L + NE +K+ + Q + A Q+ +
Sbjct: 1121 MRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENR--QNLLSQSHAYQQFLRDT 1178
Query: 4222 QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 4281
+ A+A L + ++A + + A ++ Q+ F + +++ ++ +
Sbjct: 1179 KQAEAFL----NNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRR 1234
Query: 4282 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIE 4341
+ G +QEK +S+ ++ SE RL+ + L +F + +ELS WI
Sbjct: 1235 LVSD-GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWIN 1292
Query: 4342 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 4401
E + L AQ S + L + + + +A +K +DK+ K G QL PE +
Sbjct: 1293 E-KMLTAQDMSYD-EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV 1350
Query: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
V+EK M+ ++ + +A L +A +++ T+ ++ L LE+
Sbjct: 1351 VKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLES-------- 1401
Query: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD-LAAKEIQD 4520
+ D + ++ + + L+ E K+ EEL ++Q ++ + E+
Sbjct: 1402 ---QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDS 1458
Query: 4521 KLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGID 4580
K + + ++ ER+ L E+ +F D+ + + + + + G +
Sbjct: 1459 KRLTVQTKFMELLEPLNERKHNLLASKEI-HQFNRDVEDEILWVGERMPLATSTDH-GHN 1516
Query: 4581 PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4640
++ ++ +T+++E G ++ I +++ +R+ + ++ W
Sbjct: 1517 LQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL 1576
Query: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD-QLNE 4699
L + ++R +LE+A +A Y D +A W+ + + + + + V + ++
Sbjct: 1577 LIEETEKRHRRLEEAHRAQQYYFDAAEAEA-WMSEQELYMMSEEKAKDEQSAVSMLKKHQ 1635
Query: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
+ E VE Y + + +L+ ++ + E++R +R+ +++ L+ L + R+
Sbjct: 1636 ILEQAVEDYAETVH--QLSKTSRALVADSHPESERISMRQ--SKVDKLYAGLKDLAEERR 1691
Query: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
KL+ L Q +++L W+ E + + V ++ ++
Sbjct: 1692 GKLDERH-RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1750
Query: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Q V+TVN +EL+ +S DA+++ + +N+ W +L+ + R Q L ++ + +
Sbjct: 1751 GQERVDTVNHLADELI-NSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHK 1809
Query: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT-HMELYSQLKAKEETYNQLL- 4937
+H E F R++ + G + E L H ++A QL
Sbjct: 1810 FYHDAKEIF----GRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQE 1865
Query: 4938 DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQE 4997
D RL D + ++ L + W + E R+ +L + + F + +++
Sbjct: 1866 DAARLQAAYAGDKADDIQKRENEVL--EAWKSLLDACESRRVRLVDTGD-KFRFFSMVRD 1922
Query: 4998 FINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 5057
+ W+ + + P + + L + H+ E++A D + G L L+
Sbjct: 1923 LMLWMEDVIRQIEAQEKPRDVSSVELL-MNNHQGIKAEIDARNDSFTTCIELGKSL--LA 1979
Query: 5058 QKQDVVL-IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAES 5116
+K IK L+ + + ++++ + +R L + QF WL E
Sbjct: 1980 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILE-VHQFSRDASVAEAWLLGQEP 2038
Query: 5117 HLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYD-----TTI--------RTGRALK 5163
+L S EI D+++ + +H+ F+K+ + TT+ + K
Sbjct: 2039 YLSSR-EIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2097
Query: 5164 EKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 5196
+ PE S K+ E + +WDT G+ V +
Sbjct: 2098 RRPPSPEPSTKVSE-EAESQQQWDTSKGEQVSQ 2129
Score = 154 bits (389), Expect = 3e-36
Identities = 310/1641 (18%), Positives = 660/1641 (40%), Gaps = 214/1641 (13%)
Query: 2098 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 2157
Q+ ++ A F E ++ ENQ +S + A +++EA++ + ++
Sbjct: 417 QEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEE 476
Query: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
++ V A + E E K + K + L +++ + + Q L G++++
Sbjct: 477 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 536
Query: 2218 SL-------EKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270
L E L + Y E L ++ +++A ++ Q + SAQ
Sbjct: 537 MLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEA---DIGIQAERVRGVNASAQK 593
Query: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFE 2330
F G P + Q+++ ++ ++ Y L Q AE + L KF + E E
Sbjct: 594 FATD-GEGYKPCDPQVIRDRVAHMEFCYQ-ELCQLAAERRARLEESRRLWKFFWEMAEEE 651
Query: 2331 SWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENS 2390
W+ EK L + G ++ LL + +F +++ G E +
Sbjct: 652 GWIREKEKILSS-DDYGKDLTSVMRLLSKHRAFEDEMSGRSG-------------HFEQA 697
Query: 2391 FKEGKEPSEIGNLVKDKLKDA----------TERYTALHSKCTRLGSHLNMLLGQYHQFQ 2440
KEG++ + +K+++ E+ +A+ K S L HQFQ
Sbjct: 698 IKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLL-------HQFQ 750
Query: 2441 NSADSLQAWMQACEANVEKLLSDT-VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKV 2499
AD + AWM ++ K++S + V D Q + K + EE+A ++ ++ L +
Sbjct: 751 ADADDIDAWM----LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806
Query: 2500 ARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESL 2559
A + + E +PD V+ I ++ ++ R LQ +A + E+ ++
Sbjct: 807 ASALPQEHAE-SPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DAC 861
Query: 2560 LQSIGEVEQNLEGKQVSSLSSG--VIQEALATNMKLKQDIARQKSSLEATREMVTRFMET 2617
I E EQ L Q+ VIQ + L+ ++ Q S + ++ + M +
Sbjct: 862 ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFES---LEPEMNNQASRVAVVNQIARQLMHS 918
Query: 2618 ADSTTAAV--LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENK 2675
+ + Q KL +F +L ++K++ L L Q E + + ++ K
Sbjct: 919 GHPSEKEIKAQQDKLNTRWSQFRELV--DRKKDALLSALSIQNYHLE--CNETKSWIREK 974
Query: 2676 SRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR 2735
++++ S QD+ + + L ++ + +L +E +++L L+ +H D+
Sbjct: 975 TKVIES----TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLE-SEHPDQ 1029
Query: 2736 VQ-------NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT 2788
Q + + E++ T+K RE +L +F + + FQ WL T+ +I
Sbjct: 1030 AQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLSRTQTAIASE 1088
Query: 2789 ETSMSAKELEK---QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2845
+ + E EK Q E++K+ +D++ EE K + ++ +QG+T
Sbjct: 1089 DMPNTLTEAEKLLTQHENIKNEIDNY-------EEDYQKMRDMGEMV-------TQGQTD 1134
Query: 2846 SILPSVGSSVGSVN-GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE 2904
+ + + +++ G++ + E + ++ + Y++ L + +++ +A LN E
Sbjct: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQF---LRDTKQA-EAFLNNQEY 1190
Query: 2905 V--HKEANSVLQWLES----KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958
V H E + L+ E+ +E+ + +MDA E + A E+ + +++ NS +
Sbjct: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDA-----NEEKINAVVETGRRLVSDGNINSDR 1245
Query: 2959 IQ-----------KVKEALAGLLVTYPNSQEAENWKKIQEEL----NSRWERATEVTVAR 3003
IQ K +E + LL+ ++++ + + + +EL N + A +++
Sbjct: 1246 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDE 1305
Query: 3004 QRQLEESASHLACFQAAESQLRPWL--MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKE 3061
R L F A + + WL +EKE M L ++K + + ++KE
Sbjct: 1306 ARNLHSKWLKHQAFMAELASNKEWLDKIEKEGM------------QLISEKPETEAVVKE 1353
Query: 3062 -FEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 3120
+ E L Q D + + + Q +L L+ SQI
Sbjct: 1354 KLTGLHKMWEVLESTTQTKAQRLFDAN--------KAELFTQSCADLDKWLHGLESQIQS 1405
Query: 3121 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180
D + + +V L Q + Q E K+++E E++S + L E
Sbjct: 1406 ------------DDYGKDLTSVNILLKKQQMLENQMEVRKKEIE---ELQSQAQALSQEG 1450
Query: 3181 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 3240
K DE+ KRL ++ LE L + N L A QF +
Sbjct: 1451 KST----DEVD------------SKRLTVQTKFMELLEPLNERKHNLL--ASKEIHQFNR 1492
Query: 3241 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 3300
++ W+ ++ A + L+ +Q +++N+ QK + H + I +++
Sbjct: 1493 DVEDEILWVGERM-PLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNI 1551
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
+ ++ +L +LK W L ++T R RL++ +AQ+Y + + W+
Sbjct: 1552 VTD-SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-HRAQQYYFDAAEAEAWMS 1609
Query: 3361 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 3420
+ + M D S L + + + VE + L+ + L+ S + + I
Sbjct: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
Query: 3421 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 3480
++ +++ + + + + G L+E R R FQ + ++V+ + + + +
Sbjct: 1670 SMRQSKVDKLYAGLKDLAEERRGKLDE---RHRLFQ-----LNREVDDLEQWIAEREVVA 1721
Query: 3481 SQACSNKNLEKLRAQQEVLQAL--------EPQVDYLRNFTQGLVEDAPDGSDASQLLHQ 3532
++ E + QE + + +VD + + L+ SDA+ +
Sbjct: 1722 GSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSG--HSDAATIAEW 1779
Query: 3533 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3592
+ + + ++ + +++ ++ E + +F+ +E+F ++ D +L +GRD
Sbjct: 1780 KDGLNEAWADLLELIDTRTQILAASYE-LHKFYHDAKEIFGRIQDKHKKLP--EELGRDQ 1836
Query: 3593 DSLQSQIEDVRLFLNKIH-VLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3651
+++++ L ++H + DI+A + R + E+ L + + + K+ +
Sbjct: 1837 NTVET--------LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENE 1888
Query: 3652 LTERGKARQEQLELTLGRVED 3672
+ E K+ + E R+ D
Sbjct: 1889 VLEAWKSLLDACESRRVRLVD 1909
Score = 147 bits (371), Expect = 3e-34
Identities = 312/1712 (18%), Positives = 703/1712 (41%), Gaps = 146/1712 (8%)
Query: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
+SD+N +E+L HER+ +L+ L R E++ + A + +E L + S
Sbjct: 389 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD 448
Query: 2934 K----TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI---- 2985
V+A + ++A ++ ++Q V V EAEN+ I
Sbjct: 449 NFGFDLPAVEAATKKHEAIETDIAAYEERVQAV--------VAVARELEAENYHDIKRIT 500
Query: 2986 --QEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043
++ + WE E+ AR+++LE + FQ + W+ E ++++ LS
Sbjct: 501 ARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEM-LYIMDWMDEMKVLV-----LSQ 554
Query: 3044 D--PNMLNAQKQQVQFMLKEFE--ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQ 3098
D ++L + + L E + + ++ +N +AQ T G G ++ +
Sbjct: 555 DYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVA 614
Query: 3099 SINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA------I 3152
+ + EL R +++++ S + + +++E+ + ++ + S+ +
Sbjct: 615 HMEFCYQELCQLAAERRARLEE----SRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670
Query: 3153 STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 3212
++ + + E+ + +KE + + E E + +++++R+ +
Sbjct: 671 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAE------EHFGSEKIRERIIYIRE 724
Query: 3213 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 3272
LE L+A R RL+ A + QFQ D++ W+ D + + + QS
Sbjct: 725 QWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSL 782
Query: 3273 LQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKK 3330
++++++ + + + + + + + +L P E E ++ +L ++ ++E+++
Sbjct: 783 VKKHKDVAEEIANYRPTLDTLHEQASAL-----PQEHAESPDVRGRLSGIEERYKEVAEL 837
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
T R+ L+D + + + + WI++ + ++ +++ LE R +++
Sbjct: 838 TRLRKQALQDTLALYKMFS-EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEP 896
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 3450
E+ + S + ++N A L++S E I+ ++ +N E + K +L
Sbjct: 897 EMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS 956
Query: 3451 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE-KLRAQQEVLQALEPQVDYL 3509
++ + + + +E LG+ L+ KL + L A+E ++ L
Sbjct: 957 -IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDL 1015
Query: 3510 RNFTQGLVEDAPDGSDA--SQLLHQAEVAQQEFLEVKQRVNS--GCVMMENKLEGIGQFH 3565
+ + L + PD + A S+L ++V ++ +K R S ++ L + F
Sbjct: 1016 QKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQ 1075
Query: 3566 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRH 3625
+ + +A D M + + L +Q E+++ N+I + D +
Sbjct: 1076 SWLSRTQTAIASED-----MPNTLTEAEKLLTQHENIK---NEIDNYEEDYQKMRDMGEM 1127
Query: 3626 MLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LN 3681
+ + + + L++ L+AL+ +L + + RQ L + + F R K LN
Sbjct: 1128 VTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLN 1186
Query: 3682 DATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAG 3741
+ E + G E I Q+ DF +D + K+ V G+ L+
Sbjct: 1187 NQEYVLAHTEMPTTLEGAEAAIKKQE--DF----MTTMDANEEKINAVVETGRRLVSDGN 1240
Query: 3742 KDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEEL 3801
+ D ++ ++ I+ R + N++ A + + KF + L W+ E++
Sbjct: 1241 INSD--RIQEKVDSIDDR-HRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKM 1295
Query: 3802 IANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ---SAELADREKI 3858
+ Q E + + ++ + + L K +D ++ EG ++ E +EK+
Sbjct: 1296 LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKL 1355
Query: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
TG L W L S + ++L D A+ F ++ + +L E ++ S+ G
Sbjct: 1356 TG----LHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLHGLESQI-QSDDYG 1409
Query: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS----L 3974
+ + + + LE +E ++ + Q+LS ++G ++++DS +
Sbjct: 1410 KDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS------QEGKSTDEVDSKRLTV 1463
Query: 3975 QARYSEIQDRCC-RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVL 4033
Q ++ E+ + RK LL A F D + + W+ E L++ +
Sbjct: 1464 QTKFMELLEPLNERKHNLL--ASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTV 1520
Query: 4034 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 4093
+ L +EI + +D + Q ++ ++ I+++L +K + +
Sbjct: 1521 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1580
Query: 4094 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELK 4153
+ K R LE+A + A ++ E W+ E+EL + EQ ++ ++
Sbjct: 1581 TEKRHRRLEEAHR-AQQYYFDAAEAEAWMS--EQELYMMSEEKAKDEQSAVSMLKKHQIL 1637
Query: 4154 KEVMEHRLVLDTVNEVSRALLELV--PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
++ +E +TV+++S+ LV E + S ++ Y + D +R ++D
Sbjct: 1638 EQAVED--YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLD 1695
Query: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQD-QTTAQLQVQ-KAFSIDIIRHK 4269
+ Q + D E W+AE R+++A G L QD + LQ + + F+ D
Sbjct: 1696 ERHRLFQLNREVDDLE-QWIAE--REVVA-GSHELGQDYEHVTMLQERFREFARDTGNIG 1751
Query: 4270 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 4329
+ +H ++ G + E + L + + + L R ++ A +++F
Sbjct: 1752 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR-TQILAASYELHKF 1810
Query: 4330 WETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 4389
+ +E+ I++ +LP E+L + Q + L+ H + +G
Sbjct: 1811 YHDAKEIFGRIQDKH---KKLP------EELGRDQNTVETLQRM---HTTFEHDIQALGT 1858
Query: 4390 QLKELNPEEGEMVEEKY--QKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK---- 4443
Q+++L E+ ++ Y KA+++ + E + LD S+ ++ + DK
Sbjct: 1859 QVRQLQ-EDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1917
Query: 4444 --IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 4501
+ ++ +E++ ++ P +V + +++++ E++ SF G+
Sbjct: 1918 SMVRDLMLWMEDVIRQIEAQEK-PRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKS 1976
Query: 4502 LIGRSQGADKDLAAKEIQ--DKLDQMVFFWED 4531
L+ R A +++ K +Q +K +M+ WED
Sbjct: 1977 LLARKHYASEEIKEKLLQLTEKRKEMIDKWED 2008
Score = 139 bits (350), Expect = 8e-32
Identities = 255/1435 (17%), Positives = 560/1435 (39%), Gaps = 152/1435 (10%)
Query: 4204 GQRVDEI-DAAIQRS---QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 4259
G+R+ ++ D AI+ ++YE A L W+ +T ++ L + Q Q+Q
Sbjct: 287 GKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQA 343
Query: 4260 AFSIDIIRHKDSMDE-------LFSHRSEIFGTCGEEQKTVLQEKTE---SLIQQYEAIS 4309
+ + E LF+ +S++ QK + + + + + +E +
Sbjct: 344 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRAN---NQKVYMPREGKLISDINKAWERLE 400
Query: 4310 LLNSER-------YARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQ 4362
ER R E+ + L +F W+ E + L++Q + D +
Sbjct: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQ-DNFGFDLPAVEA 459
Query: 4363 QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
++ + IA ++ + ++ + +L+ N + + + + ++ + E +R
Sbjct: 460 ATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRA 519
Query: 4423 RA------LALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECIS 4476
R L L + + I ++ D+++ ++ + + L + L+
Sbjct: 520 RRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLL------------ 567
Query: 4477 DNKSATVELEKLQPSFEALKRRGEELIGRSQGAD----KDLAAKEIQDKLDQMVFFWEDI 4532
K VE + +A + RG + D K + I+D++ M F ++++
Sbjct: 568 -QKHTLVEADI---GIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQEL 623
Query: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
A ER + + L + FW +MA I++ + I+ + G D + + + +
Sbjct: 624 CQLAAERRARLEESRRLWKFFW-EMAEEEGWIREKEKILSS-DDYGKDLTSVMRLLSKHR 681
Query: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652
++E G E G D+I A ++R+ I + W NL + R ++L
Sbjct: 682 AFEDEMSGRSGHFEQAIKEGEDMI-AEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRL 740
Query: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQI 4712
E+A Q+Q + W+ + ++K+ + VG D + + + + K+ E+ +
Sbjct: 741 EEA-SLLHQFQADADDIDAWMLD-ILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
Query: 4713 EMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4772
++ L+ Q + ++ + D +R L+ ++ ++ + E R+ L+ L F
Sbjct: 799 TLDTLHEQASALPQEHAESPD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMF 855
Query: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHV--LKNDVLAHQATVETVNKA 4830
A + W+ E+ L+ + K+ ++E+ +H L+ ++ + V VN+
Sbjct: 856 SEA-DACELWIDEKEQWLNNMQI---PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQI 911
Query: 4831 GNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH---SEIED 4887
+L+ S + ++++ + +N W + + ++ L S L Q +H +E +
Sbjct: 912 ARQLMHSGHPSE-KEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETKS 969
Query: 4888 FLLELTRM-ESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4946
++ E T++ ES G+ R+ +L + ++AK + +K L
Sbjct: 970 WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVA-IEAKLSDLQKEAEK-----LE 1023
Query: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
+ +A + W + + ++ R++ L EA L +F L +F +WL+ +
Sbjct: 1024 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ-QFLRDLDDFQSWLSRTQ 1082
Query: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
++ P+ L + +H+ NE++ + + ++ G + + ++
Sbjct: 1083 TAIASEDMPNT-LTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
Query: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
L ++ + W ++ + E ++L +QF K+ +L + E L + E+
Sbjct: 1142 QRLQALDTGWNEL-HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPT 1199
Query: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKW 5186
+ + + K ++F T+ + + + TGR L + D +++K
Sbjct: 1200 TLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSD---------RIQEKV 1250
Query: 5187 DTVCGKSVERQHKLEEALLFSGQFMDALQALVDW----LYKVEPQLAEDQPVHGDLDLVM 5242
D++ + + + E L+ D + L D L+ E L + + +
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
Query: 5243 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 5302
+ H+ F EL + +++ G +LI + VK +L L W+ + +
Sbjct: 1311 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1370
Query: 5303 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-----LQSLIDTHK 5357
+K RL A K AE+F + L +WL E ++ D T Q +++
Sbjct: 1371 TKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQM 1429
Query: 5358 EFMKK-VEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQR 5416
E KK +EE + + G+ + ++ +F E+L + +
Sbjct: 1430 EVRKKEIEELQSQAQALSQEGK---------STDEVDSKRLTVQTKFMELLEPLNERKHN 1480
Query: 5417 LETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTR 5476
L + N ++ +E+L W + N+ V+ LI ++QT +E+
Sbjct: 1481 LLASKEIHQFNRDVEDEIL----WVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQG 1536
Query: 5477 KQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQL 5536
QP +D + + + +NI + S I Q
Sbjct: 1537 HQPRIDDIFE--RSQNI----------------------------VTDSSSLSAEAIRQR 1566
Query: 5537 SARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVM 5591
A +Q+W L +E K + RLEE + FD + WM+ ++ +M
Sbjct: 1567 LADLKQLWGLLIEETEKRH---RRLEEAHRAQQYYFDAAEAE--AWMSEQELYMM 1616
Score = 99.0 bits (245), Expect = 1e-19
Identities = 258/1413 (18%), Positives = 529/1413 (37%), Gaps = 210/1413 (14%)
Query: 1817 LRNIEMRTKQIQPL-ELNLAELQDLL-----------CQAKVLERE-----------LKD 1853
L IE R K++ L L LQD L C+ + E+E L+D
Sbjct: 824 LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED 883
Query: 1854 LTTLVSQELECVNQIIISQPQEVPA--QLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQN 1911
L ++ E + + +Q V Q+ + L +K + + D N+R F+
Sbjct: 884 LE-VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE 942
Query: 1912 AVEIEKTKVLN----QHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYE 1967
V+ +K +L+ Q+ LE + ++W+ K ++ S D+ + ++
Sbjct: 943 LVDRKKDALLSALSIQNYHLE--CNETKSWIREKTKVIESTQDLGN-DLAGVMALQRKLT 999
Query: 1968 DLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQ 2027
+++ + +A+L L + + SEH P Q + +L L E+ +++ ++ T
Sbjct: 1000 GMERDLVAIEAKLSDLQKEAEKLESEH-----PDQAQAILSRLAEISDVWEE-MKTTLKN 1053
Query: 2028 VDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSAL 2087
+A G +++Q + L+D SW+ + + A+A T L+
Sbjct: 1054 REASLGEASKLQQFL-------------RDLDDFQSWLSRTQTAIASEDMPNT---LTEA 1097
Query: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
+K + ++++++I N + ++D+ + + QT + LR++L +
Sbjct: 1098 EKLLTQHENIKNEIDNYEEDYQK-MRDMGEMVTQGQT---DAQYMFLRQRLQALDTGWNE 1153
Query: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQL--- 2204
L + Q L + + A QQ +K A+ N++ + A + T++ + +
Sbjct: 1154 LHKMWENRQNLLSQ--SHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1211
Query: 2205 ---LTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNF 2261
+T + E+ A +E G +DG + ++ EK+D
Sbjct: 1212 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVD-------------------- 1251
Query: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK 2321
+ D+H N ++ + L LK+ +LQK
Sbjct: 1252 --------SIDDRHRKN-----RETASELLMRLKD-------------------NRDLQK 1279
Query: 2322 FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 2381
FLQD +E W+ +EK L L S + +F ++ S+K L + G
Sbjct: 1280 FLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEG 1337
Query: 2382 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 2441
+++ E E +VK+KL + + L S T+ + + F
Sbjct: 1338 MQLI---------SEKPETEAVVKEKLTGLHKMWEVLES-TTQTKAQRLFDANKAELFTQ 1387
Query: 2442 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 2501
S L W+ E+ ++ SD D + L + L+ ++ + +E+LQ A+
Sbjct: 1388 SCADLDKWLHGLESQIQ---SDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQ 1444
Query: 2502 DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQ 2561
+ + EG+ + V ++ + F L L ER L A + +E +
Sbjct: 1445 ALSQ-EGKSTDE---VDSKRLTVQTKFMELLEPLNERKHNL-LASKEIHQFNRDVEDEIL 1499
Query: 2562 SIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADST 2621
+GE L + +Q + N L+++I + ++ E + + S
Sbjct: 1500 WVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSL 1558
Query: 2622 TAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2681
+A ++ +LA++ Q + L +++ EK + +A+ + + + + +M + + S
Sbjct: 1559 SAEAIRQRLADLKQLW-GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMS 1617
Query: 2682 GN--QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQD----- 2734
+ +Q ++ Q L +ED E V +LS AL H +
Sbjct: 1618 EEKAKDEQSAVSMLKKHQILEQAVEDYAET-------VHQLSKTSRALVADSHPESERIS 1670
Query: 2735 -RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMS 2793
R + K + L+ +ER + +L + + V ++W+ E E E
Sbjct: 1671 MRQSKVDKLYAGLKDLAEERRGKLDE-RHRLFQLNREVDDLEQWIAEREVVAGSHELGQD 1729
Query: 2794 AKELEKQIEHLKSLLDDWASKG-TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVG 2852
+ + E + D + G V+ +N L N A ++ K G
Sbjct: 1730 YEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL------ 1783
Query: 2853 SSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 2912
DL E + D + LH+ + I R+++ HK+
Sbjct: 1784 --------NEAWADLLE----LIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEE 1831
Query: 2913 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVT 2972
L ++ E L+ M + F +++ ++++++E A L
Sbjct: 1832 LGRDQNTVETLQRM------------------HTTFEHDIQALGTQVRQLQEDAARLQAA 1873
Query: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
Y +A++ +K + E+ W+ + +R+ +L ++ F L W ME
Sbjct: 1874 YA-GDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR-DLMLW-MEDV 1930
Query: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 3092
+ D + + Q + E +AR E + +L ++ +
Sbjct: 1931 IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK---HYASEE 1987
Query: 3093 VQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE---------LLQDLSEKVRAVG 3143
++++L + +K E+ DK R + + I++ Q+ L Q+ R +G
Sbjct: 1988 IKEKLLQLTEKRKEMIDKWEDRWEWL-RLILEVHQFSRDASVAEAWLLGQEPYLSSREIG 2046
Query: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL 3176
Q + + + EA ++ E S LE+L
Sbjct: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERL 2079
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 187 bits (474), Expect = 4e-46
Identities = 412/2034 (20%), Positives = 813/2034 (39%), Gaps = 257/2034 (12%)
Query: 3436 EELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF----DALGSQACSNKNL-- 3489
EE+Q + +E+ R + F+E +K+E + H L++F D LG N+
Sbjct: 22 EEIQERR---QEVLTRYQSFKERVAERGQKLEDSYH-LQVFKRDADDLGKWIMEKVNILT 77
Query: 3490 -------EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3542
++ + + Q+LE +V L + + H+ A E L
Sbjct: 78 DKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELR 137
Query: 3543 VKQRVNSGCVMMENKLEGIGQF--HCRVREMFSQLADLDDELDGMGAI------GRD--- 3591
+ +++E LE Q + ++ + AD+ + + AI G D
Sbjct: 138 -----HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWER 192
Query: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGK 3651
T+ L + ED ++ L +++ EC EE DL ++ + +N +
Sbjct: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECA----EENHPDLPLIQSKQNEVNAAWER 248
Query: 3652 LTERGKARQEQLELT-LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ--- 3707
L RG A Q Q L+ ++ F R + EA+QW+ E + ++
Sbjct: 249 L--RGLALQRQKALSNAANLQRFKRDV------------TEAIQWIKEKEPVLTSEDYGK 294
Query: 3708 --LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK-----DCDVQGLEHDMEEINARW 3760
+A +F + L+ L ++ + L A K D ++ E++ + W
Sbjct: 295 DLVASEGLFHSHK--GLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSW 352
Query: 3761 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS--AEYKVVKAQ 3818
+ R +LQ + +F + L W+ + I + P+ A +V+ +
Sbjct: 353 EHIRALATSRYEKLQATYWY-HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
Query: 3819 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAA 3878
Q+ K DDR + D E G+ +A +++ ++E L++ WT LL
Sbjct: 412 HQQHKHEIDSYDDRFQSAD----ETGQDLVNANHEASDEVREKMEILDNNWTALLELWDE 467
Query: 3879 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3938
R +Q E L F+ +E + ++S E L N E +G + + +H+ EE
Sbjct: 468 RHRQYEQCLDF-HLFYRDSEQVDSWMSRQEAFLEN-EDLGNSLGSAEALLQKHEDFEEAF 525
Query: 3939 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSN 3998
+ K L + + + + D L AR ++++ + LL ++L
Sbjct: 526 TAQEEKIITVDKTATKLIGDDHYDSENIKAIR-DGLLARRDALREKAATRRRLLKESLLL 584
Query: 3999 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDF--------KQDVLHRQHADHLALNE-EIVN 4049
+L+ ED ++ NW+ + + KD KQ V ++ LA+N+ ++ N
Sbjct: 585 QKLY-EDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKE----LAVNKTQLEN 639
Query: 4050 RKKNVDQAIKNGQALLKQTTGE--EVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQL 4107
+K + I+ G T EV + E+L + T K + E +QL
Sbjct: 640 IQKTGQEMIEGGHYASDNVTTRLSEVASLWEEL---------LEATKQKGTQLHEANQQL 690
Query: 4108 ATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE---LKKEVMEHRLVLD 4164
+F++ E+L WL +VE ++ + G+ + + Q R ++ L+ V + +D
Sbjct: 691 --QFENNAEDLQRWLEDVEWQVTSED----YGKGLAEVQNRLRKHGLLESAVAARQDQVD 744
Query: 4165 TVNEVSRALLEL-----VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
+ +++ E+ RAR+ + LV +++ + + + R ++ +
Sbjct: 745 ILTDLAAYFEEIGHPDSKDIRARQ--ESLVC----RFEALKEPLATRKKKLLDLLHLQLI 798
Query: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDII-RHKDSMDELFSH 4278
D E AW+ ET E T+ L S ++ RH+ ++ + SH
Sbjct: 799 CRDTEDEE-AWIQET------------EPSATSTYLGKDLIASKKLLNRHRVILENIASH 845
Query: 4279 RSEIFGTCGEEQKTV---------LQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 4329
I K V + + +SL Q E++ + R LE A V Q+
Sbjct: 846 EPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLE-ANVQFQQY 904
Query: 4330 WETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 4389
E WI E P +D+ +E L + +H+ + L G
Sbjct: 905 LADLHEAETWIREKE--------PIVDNTNYGADEEAAGAL---LKKHEAFLLDLNSFGD 953
Query: 4390 QLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLE 4449
+K L + +++ E + + QR +AL + ++S + E K +L
Sbjct: 954 SMKALRNQANACQQQQAAPVEGVAGE------QRVMALYDFQARSPR--EVTMKKGDVLT 1005
Query: 4450 TLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL-QPSFEALKRRGEELIGRSQG 4508
L +++ + K+ V + +L F L +R E G
Sbjct: 1006 LLSSINK----------DWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGN--- 1052
Query: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFW--YDMAALLTTIKD 4566
I + +Q+ + + RAEER + +L+ +F Y+ +L I++
Sbjct: 1053 ---------ITQRQEQIENQYRSLLDRAEERRRR---LLQRYNEFLLAYEAGDMLEWIQE 1100
Query: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
+ E+ G++ + + + + +++ + L I + DL+F T PE
Sbjct: 1101 KK-----AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLT--PE 1153
Query: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
+ E+N+ W +L + E+ + L A V +++ + ++ L P
Sbjct: 1154 GAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTK-EQIEKKCQALSAADP- 1211
Query: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
G+DL +V+ + F+ ++ ++ L E + + D T+ D+ R+ + EL
Sbjct: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATE-DLQRQKM-ELNE 1269
Query: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
WE+L + R+ L A F +L +W++ ++ +Q ++ D IE+
Sbjct: 1270 AWEDLQGRTKDRKESLNEAQ-KFYLFLSKARDLQNWISSIGGMVSSQE-LAEDLTGIEIL 1327
Query: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS-SLRSRLEAMNQCWESVLQKTE 4865
L +H + D+ A T + + EL++S G AS + +L+A+ + + + E
Sbjct: 1328 LERHQEHRADMEAEAPTFQALEDFSAELIDS--GHHASPEIEKKLQAVKLERDDLEKAWE 1385
Query: 4866 EREQQLQSTL--QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4923
+R++ L L Q QG ++E +++ R S S K + E ++ D +L
Sbjct: 1386 KRKKILDQCLELQMFQGNCDQVESWMV--ARENSLRSDDKSSLDSLEALMKKRD---DLD 1440
Query: 4924 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983
+ A+E L ++ D+ + + + + +W + +++ + ++KL +
Sbjct: 1441 KAITAQEGKITDLEHFAESLIA--DEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGD 1498
Query: 4984 ALNLATEFQNSLQEFINWL-----TLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 5038
NL +F L+E W+ T ++S A+ + + +H+ FA+EV+
Sbjct: 1499 YANLK-QFYRDLEELEEWISEMLPTACDESYKDAT-------NIQRKYLKHQTFAHEVDG 1550
Query: 5039 HRDQIIELDQTGNQLKFLSQKQ-DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
+Q+ + GN L S + +K L ++ W+ +++R+ ++G+ L++A R
Sbjct: 1551 RSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEA-SRQ 1609
Query: 5098 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157
++F+ + + WL +AE+ L + + + D L KH+ ++ + ++
Sbjct: 1610 QRFNTSIRDFEFWLSEAETLLAMK-DQARDLASAGNLLKKHQLLEREMLARED------- 1661
Query: 5158 TGRALKEKTLLPEDSQKLDNF-LGEVRDKWDTVCGKSVERQH-------KLEEALLFSGQ 5209
ALK+ L ED F + ++ K D V + + Q KL+EA Q
Sbjct: 1662 ---ALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF-Q 1717
Query: 5210 FMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 5267
F L W +E +L Q DL V NL+ HK + EL +Q +
Sbjct: 1718 FFQDLDDEESW---IEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLD 1774
Query: 5268 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
+L + + ++ +L + W+ + +L+ ++ +LE++L+ + F
Sbjct: 1775 MAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQ-FMQNAEEEEA 1833
Query: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL 5381
W++E + L RG D A QSL+ H+ V + A GE IL
Sbjct: 1834 WINE-KNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDIL 1886
Score = 182 bits (463), Expect = 7e-45
Identities = 455/2378 (19%), Positives = 937/2378 (39%), Gaps = 286/2378 (12%)
Query: 2977 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 3036
+ AE ++ ++E+ +R++ E R ++LE+S HL F+ L W+MEK +
Sbjct: 19 ETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIMEK---VN 74
Query: 3037 VLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 3095
+L S DP + + Q+ Q + E + + + +L + + T T +
Sbjct: 75 ILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIE 134
Query: 3096 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 3155
EL+ + +ELT + + ++++ ++Q+ +Q+ ++ + +G + AI+T
Sbjct: 135 ELRHLWDLLLELTLEKGDQ-------LLRALKFQQYVQECADILEWIGDK----EAIATS 183
Query: 3156 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE-----LKKRLETV 3210
E + + E T + E E+ + E++ E ++ ++ + V
Sbjct: 184 VE-LGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEV 242
Query: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
+ L LA R L A A+ Q+F++ E W+ +K+ L +
Sbjct: 243 NAAWERLRGLALQRQKALSNA-ANLQRFKRDVTEAIQWIKEKEPVLTSE-DYGKDLVASE 300
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
++ +++L S + + A+ E L LS P + +Q +L + WE +
Sbjct: 301 GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHP--SDAPQIQEMKEDLVSSWEHIRAL 358
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
R +L+ ++ ++L W+ + A ++ + D E L R + +
Sbjct: 359 ATSRYEKLQ-ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKH 417
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 3450
E++ + + L+N++ D +R++ ++ N A+ E + E+
Sbjct: 418 EIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLD 477
Query: 3451 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3510
F + ++ + + LE D S + L+K +E A E ++ +
Sbjct: 478 -FHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVD 536
Query: 3511 NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE 3570
L+ D S+ + + +A+++ L K + L+ + + ++
Sbjct: 537 KTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKN 596
Query: 3571 MFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEE 3630
++ L D+ D +D +L+S+++ ++F ++ V K +E + + M+E
Sbjct: 597 WINKKKKLADDEDY-----KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGG 651
Query: 3631 GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGR---VEDFYRKLKGLNDATTAA 3687
A + +L+E +E LE T + + + ++L+ N+A
Sbjct: 652 HY-----------ASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQ 700
Query: 3688 EEAEALQWVVGTE------VEIINQQ-----LADFKMFQKEQVDPLQMKLQQVNGLGQGL 3736
E ++W V +E E+ N+ L +++QVD L +G
Sbjct: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHP- 759
Query: 3737 IQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3796
D + + E + R+ L + +A R +L + LLH E +W+
Sbjct: 760 --------DSKDIRARQESLVCRFEALKEPLATRKKKLLD-LLHLQLICRDTEDEEAWIQ 810
Query: 3797 DTEELIANQKPPSAEYKVVKAQIQEQKLLQR---LLDD---RKATVDMLQAEGGRIAQSA 3850
+TE P + + K I +KLL R +L++ + + + G ++ +
Sbjct: 811 ETE-------PSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEG 863
Query: 3851 ELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAK---QFHETAEPISDFLSVT 3907
A E + +++SL L ++AA RQ LE + + HE I +
Sbjct: 864 HFA-AEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIRE----- 917
Query: 3908 EKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVL 3967
++ + ++ G + +H+A D+ + + + + +GV
Sbjct: 918 KEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVA 977
Query: 3968 SEKIDSLQARYSEIQDRCCRKAALLD-QALSNARLFGEDEVEVLNWLAEVEDK---LSSV 4023
E+ + A Y + Q R R+ + L+ +D W E D + +V
Sbjct: 978 GEQ--RVMALY-DFQARSPREVTMKKGDVLTLLSSINKDW-----WKVEAADHQGIVPAV 1029
Query: 4024 FVKDFKQDVL------HRQHADHLALNEEIVNRKKN--VDQAIKNGQALLKQTTGEEVLL 4075
+V+ D R+ ++ +E + + +D+A + + LL++ E LL
Sbjct: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYN--EFLL 1087
Query: 4076 IQEK---LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
E L+ I+ + A+ T + L++ K +T E + +V ++L
Sbjct: 1088 AYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFE 1147
Query: 4133 GGQSPTGEQIPQ-FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSD 4191
G +P G QI Q R L++ E R +L + + V E + D
Sbjct: 1148 GLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAV-------------EVFHREADD 1194
Query: 4192 ANEQYKLVSDTI-----GQRVDEIDAAIQRSQQYEQ---AADAELAWVAETKRKLMALGP 4243
EQ + + G + + A +R + +E+ ++ + ET +L P
Sbjct: 1195 TKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP 1254
Query: 4244 IRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVL-QEKTESLI 4302
T LQ QK + ++ ++L + + E QK L K L
Sbjct: 1255 ------DATEDLQRQK------MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQ 1302
Query: 4303 QQYEAIS-LLNSERYAR-LERAQVLVNQFWETYEEL---SPWIEETRALIAQL------P 4351
+I +++S+ A L ++L+ + E ++ +P + A+L
Sbjct: 1303 NWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHA 1362
Query: 4352 SPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV--EEKYQKA 4409
SP I+ ++L+ + E L ++ + K +D+ L++ + E MV E +
Sbjct: 1363 SPEIE-KKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSD 1421
Query: 4410 ENMYAQIKEEVRQRALALDEAVS-QSTQITEFHDKIEPMLE----TLENLSSRLRM---- 4460
+ E + ++ LD+A++ Q +IT+ E ++ E +++RL+
Sbjct: 1422 DKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDR 1481
Query: 4461 -----PPLIPA---------------EVDKIRECISDNKSATVE-----LEKLQPSFEAL 4495
LI +++++ E IS+ + +Q +
Sbjct: 1482 WKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKH 1541
Query: 4496 KRRGEELIGRSQGADK--------------DLAAKEIQDKLDQMVFFWEDIKARAEEREI 4541
+ E+ GRS+ D + ++++L+Q+ W+ + R ++
Sbjct: 1542 QTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGK 1601
Query: 4542 KFLDVLELAE--------KFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET 4593
K + +FW A L +KD DL S G +++K+ +
Sbjct: 1602 KLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQ---ARDLASAG---NLLKKH----QL 1651
Query: 4594 IKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4653
++ E + L+ + L DL+ + G ++ K D +N + N+ + EKL+
Sbjct: 1652 LEREMLAREDALKDLNTLAEDLL-SSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLK 1710
Query: 4654 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4713
+A A Q+ L W++ +I++ + G DL V++ L + K + E+ +
Sbjct: 1711 EAY-ALFQFFQDLDDEESWIEEKLIRVSSQD-YGRDLQGVQNLLKKHKRLEGELVAHEPA 1768
Query: 4714 MEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQ 4773
++ + E + KA ++ I+ L + WE L E R KLE +L L QF
Sbjct: 1769 IQNVLDMAEKLKDKAA--VGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL-QFM 1825
Query: 4774 HALEELMSWLTHTEELLDAQRPISGDP-KVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832
EE +W+ L A R GD + L KH L+ND H+ V+ V G
Sbjct: 1826 QNAEEEEAWINEKNAL--AVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGE 1883
Query: 4833 ELLESSAGDDASS--LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLL 4890
++L +++ + + S++EA+N+ S+ + + QL+ Q F+ + +
Sbjct: 1884 DILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD-YAFQEFNWKADVVEA 1942
Query: 4891 ELTRMESQLSASKPTGGLPE-----TAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLL 4945
+ E+ L + L + ++ LD ++ + Q + E T L DK L+
Sbjct: 1943 WIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEIT--DLKDK----LI 1996
Query: 4946 SRDDSGSGSKTEQSVALLEQKWH-------VVSSKMEERKSKLEEALNLATEFQNSLQEF 4998
S + S + E+ ALL ++W V K+ E++ L++A +L EF +
Sbjct: 1997 SAQHNQSKAIEERYAALL-KRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASAL 2055
Query: 4999 INWLTLAEQSLNIASPPSLI-LNTVLSQIEEHKVF-ANEVNAHRD--QIIELDQTGNQLK 5054
NW E+ N++ P + LN + ++H+ F A+ A D ++ELDQ L
Sbjct: 2056 NNWCEKMEE--NLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
Query: 5055 FLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL--DDAR-----KRAKQFHEAWKKL 5107
S + ++ L + W+ + ER + L ++AR + ++F +
Sbjct: 2114 VPSSPYTWLTVEVL----ERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTF 2169
Query: 5108 IDWLEDAESH-LDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKT 5166
+ W+ + ++ LD L + ++ QL +K QK + + + G L++
Sbjct: 2170 LQWILETRAYFLDGSL--LKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDAL 2227
Query: 5167 LLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEAL 5204
+L + + +WD + + QH LE+ +
Sbjct: 2228 ILDIKYSTIG-----LAQQWDQLYQLGLRMQHNLEQQI 2260
Score = 179 bits (454), Expect = 7e-44
Identities = 492/2662 (18%), Positives = 1023/2662 (38%), Gaps = 400/2662 (15%)
Query: 1910 QNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDL 1969
+ VE KVL +++ R Q++ + + +G E D L + + +DL
Sbjct: 7 ETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLE-DSYHLQVFKRDADDL 65
Query: 1970 KQPMAERKAQLDALAFD----IQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDIL---- 2021
+ + E+ L +++ IQ +H + Q + RL++EL+++ ++
Sbjct: 66 GKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKS--RLMSELEKTREERFTMGH 123
Query: 2022 ---EQTAAQVDALQGHLQQM-------EQEALVKTLQKQQNTCHQQLEDLCSWVGQAERA 2071
E+T A ++ L+ HL + + + L++ L+ QQ Q+ D+ W+G E
Sbjct: 124 SAHEETKAHIEELR-HLWDLLLELTLEKGDQLLRALKFQQYV--QECADILEWIGDKEAI 180
Query: 2072 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 2131
+ + L K +D Q ++ + V + EEN +L
Sbjct: 181 ATSVELGEDWERTEVLHKK---FEDFQVELVAKEGRVVEVNQYANECAEENHP-----DL 232
Query: 2132 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALL 2191
++ K ++ +E L+ ALQ++ S AA L K+ + +
Sbjct: 233 PLIQSKQNEVNAAWERLRG--------------LALQRQKALSNAAN-LQRFKRDVTEAI 277
Query: 2192 DWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY-------MGVNQAPEKLDKQC 2244
W+ EK + T++ Y G+ + + L++
Sbjct: 278 QWIK------------------------EKEPVLTSEDYGKDLVASEGLFHSHKGLERNL 313
Query: 2245 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQ 2304
+M + +EL ++ + L+ S P+ Q+M + + ++ +LA
Sbjct: 314 AVMSDKVKELCAKAEKLTLSHPSD-----------APQIQEMKEDLVSSW--EHIRALAT 360
Query: 2305 SEAELKQVQTLQDELQKFLQDHKEFESWLER-----SEKELENMHKGGSSPETLPSLLKR 2359
S E Q +F D E W+ + EL GG LL R
Sbjct: 361 SRYEKLQATYWY---HRFSSDFDELSGWMNEKTAAINADELPTDVAGGEV------LLDR 411
Query: 2360 QGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALH 2419
++ S+ + +GQ +++ + E + V++K++ +TAL
Sbjct: 412 HQQHKHEIDSYDDRFQSADETGQDLVNANH---------EASDEVREKMEILDNNWTALL 462
Query: 2420 SKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL-LSDTVASDPGVLQEQLAT 2478
L +H F ++ + +WM EA +E L +++ S +LQ+
Sbjct: 463 ELWDERHRQYEQCL-DFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKH--- 518
Query: 2479 TKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER 2538
+ +E + EK+ V + ++ G+ D +++ D +L+ +L A R
Sbjct: 519 -EDFEEAFTAQE---EKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATR 574
Query: 2539 SSLLQKAIAQSQSVQES--LESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
LL++++ + ++S L++ + ++ + + K + +L S V ++ + +++
Sbjct: 575 RRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQV-----FEKE 629
Query: 2597 IARQKSSLE----ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2652
+A K+ LE +EM+ +D+ T +L+EV+ +E+L ++K + L
Sbjct: 630 LAVNKTQLENIQKTGQEMIEGGHYASDNVTT-----RLSEVASLWEELLEATKQKGTQLH 684
Query: 2653 KLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPD--QDITHFFQQIQELNLEMEDQQENL 2710
+ Q + FE+ + LQ+++E+ + S + ++ + ++ L + +Q+ +
Sbjct: 685 EANQQLQ-FENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQV 743
Query: 2711 DTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS-------CQEQ 2763
D L L G D + R ++L F L++ + R+K C++
Sbjct: 744 DILTDLAAYFEEIGHP-DSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT 802
Query: 2764 LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINC 2823
DE + W++ETE S T +K + + +L++ AS ++EI
Sbjct: 803 EDE--------EAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITE 854
Query: 2824 KGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK 2883
+G + G+ +D + + +N E
Sbjct: 855 RGNKMVE----------------------------EGHFAAED---VASRVKSLNQNMES 883
Query: 2884 LGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAE 2943
L RQ L+A + + ++ + + W+ KE + +D + E A +
Sbjct: 884 LRARAARRQNDLEANV-QFQQYLADLHEAETWIREKEPI---VDNTNYGADEEAAGALLK 939
Query: 2944 SNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVAR 3003
++AFL +L ++ ++ Q + + A VA
Sbjct: 940 KHEAFLLDLNSFGDSMKALRN---------------------QANACQQQQAAPVEGVAG 978
Query: 3004 QRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 3063
++++ +A + R M+K ++ +L SI+ + + Q ++
Sbjct: 979 EQRV------MALYDFQARSPREVTMKKGDVLTLLS--SINKDWWKVEAADHQGIVPAVY 1030
Query: 3064 ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIV 3123
RR H++ Q PG+++ Q++ + +S+ + E +L R ++ +
Sbjct: 1031 VRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNE----FL 1086
Query: 3124 KSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEA 3183
+ + ++L+ + EK +A + + Q ++ E + DL + +++
Sbjct: 1087 LAYEAGDMLEWIQEK-KAENTGVELDDVWELQ--------KKFDEFQKDLNTNEPRLRDI 1137
Query: 3184 QTLCDELSVLIGEQYLKDE---LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 3240
+ D+ L+ E L E +++ L + LQ L AD +L + + + F +
Sbjct: 1138 NKVADD---LLFEGLLTPEGAQIRQELNSRWGSLQRL----ADEQRQLLGSAHAVEVFHR 1190
Query: 3241 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 3300
D+ + + +K+ Q + L +Q+ + +E F++ L ++ E L
Sbjct: 1191 EADDTKEQI-EKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERL 1249
Query: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
S P E LQ Q +EL WE+L +T DR+ L + QK + DL WI
Sbjct: 1250 SESHPDATE--DLQRQKMELNEAWEDLQGRTKDRKESLNEA-QKFYLFLSKARDLQNWIS 1306
Query: 3361 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 3420
+S + D +E L R + ++E + L + LI+S I
Sbjct: 1307 SIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI 1366
Query: 3421 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFD--A 3478
+ + D + + + + L++ + L+ FQ + +E + ++ L D +
Sbjct: 1367 EKKLQAVKLERDDLEKAWEKRKKILDQCLE-LQMFQGNCDQVESWMVARENSLRSDDKSS 1425
Query: 3479 LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ 3538
L S K + L + + A E ++ L +F + L+ +D + Q
Sbjct: 1426 LDSLEALMKKRDDL---DKAITAQEGKITDLEHFAESLI------ADEHYAKEEIATRLQ 1476
Query: 3539 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIG-----RDTD 3593
L+ + + + + KL + +++ + L +L++ + M +D
Sbjct: 1477 RVLDRWKALKAQLIDERTKLGD----YANLKQFYRDLEELEEWISEMLPTACDESYKDAT 1532
Query: 3594 SLQSQIEDVRLFLNKIH--------VLKLDIEASEAECRHMLEEEGTLDLLGLKRELEAL 3645
++Q + + F +++ V+ L E EE +K +LE L
Sbjct: 1533 NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE-------AMKEQLEQL 1585
Query: 3646 NKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LNDATTAAEEAEALQWVVGTEV 3701
+ L ER + ++L R + F ++ L++A T + + +
Sbjct: 1586 KEHWDHLLERTNDKGKKLN-EASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGN 1644
Query: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3761
+ QL + +M +E L+ +N L + L+ S +V + + +N R+
Sbjct: 1645 LLKKHQLLEREMLAREDA------LKDLNTLAEDLLSSG--TFNVDQIVKKKDNVNKRFL 1696
Query: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-ANQKPPSAEYKVVKAQIQ 3820
+ + A +L+EA FQD L+ SW+ E+LI + + + + V+ ++
Sbjct: 1697 NVQELAAAHHEKLKEAYALFQFFQD-LDDEESWI--EEKLIRVSSQDYGRDLQGVQNLLK 1753
Query: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
+ K L+ L + + + ++ A + +E+I +L W +L A AR
Sbjct: 1754 KHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVG-QEEIQLRLAQFVEHWEKLKELAKARG 1812
Query: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
+LE+ L QF + AE +++ + LA G A Q +++H+ALE D
Sbjct: 1813 LKLEESLEYL-QFMQNAEEEEAWIN-EKNALAVRGDCGDTLAATQSLLMKHEALENDFAV 1870
Query: 3941 HATDVHQAVKIGQSLSS--LTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSN 3998
H T V G+ + + L ++ +S KI++L K L +A++
Sbjct: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN-----------EKTPSLAKAIAA 1919
Query: 3999 ARLFGEDE--VEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQ 4056
+L ED+ + NW A+V + ++ D + + + L ++ ++ +D
Sbjct: 1920 WKLQLEDDYAFQEFNWKADVVE----AWIADKETSLKTNGNGADLGDFLTLLAKQDTLDA 1975
Query: 4057 AIKNGQALLKQTTGEEVLLIQEKL--------DGIKTRYADI-----------TVTSSKA 4097
++++ Q Q E+ +++KL I+ RYA + V K
Sbjct: 1976 SLQSFQ----QERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKL 2031
Query: 4098 LR---TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKK 4154
L L++A L +F L W ++EE L + + +I Q Q+ ++
Sbjct: 2032 LEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENL-SEPVHCVSLNEIRQLQKDHEDFLA 2090
Query: 4155 EVMEHRLVLDTVNEVSRALLEL-VP-----WRAREGLDKLVSDANEQYKLVSDTIGQRVD 4208
+ + + E+ + + L VP W E L++ +K +SD I +R
Sbjct: 2091 SLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLER-------TWKHLSDIIEEREQ 2143
Query: 4209 EIDAAIQRS-------QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF 4261
E+ R Q++EQ A L W+ ET+ + G + E +QL+ K
Sbjct: 2144 ELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLD-GSLLKETGTLESQLEANKRK 2202
Query: 4262 SIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK--TESLIQQYEAISLLNSERYARL 4319
+I K + ++ + E +L K T L QQ++ + L L
Sbjct: 2203 QKEIQAMKRQLTKIVDLGDNL------EDALILDIKYSTIGLAQQWDQLYQLGLRMQHNL 2256
Query: 4320 ERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIA--EH 4377
E+ Q+ EE + + + H++ R + + EH
Sbjct: 2257 EQ-QIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEH 2315
Query: 4378 KPHIDKLL-KIGPQLK----------------ELNPEEGEMVEEKYQKAENMYAQIKEEV 4420
+P +K L + P K N + + +E +Q + I +E
Sbjct: 2316 EPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKED 2375
Query: 4421 RQRALALDEAVSQSTQITEFHD 4442
++AL ++ +T + ++ D
Sbjct: 2376 MKQALTPEQVSFCATHMQQYMD 2397
Score = 173 bits (439), Expect = 4e-42
Identities = 426/2329 (18%), Positives = 930/2329 (39%), Gaps = 168/2329 (7%)
Query: 3092 QVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA 3151
+ +E+Q Q+ + R ++ Q + S Q +D + + + +++++ +
Sbjct: 19 ETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTD 78
Query: 3152 ISTQ-PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV 3210
S + P ++ + ++ + ++++ + E + +E + + +E K +E +
Sbjct: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAH--EETKAHIEEL 136
Query: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
L +L ++ ++L AL Q Q+ D L W+ DK++ A + + ER +
Sbjct: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILE-WIGDKEAI-ATSVELGEDWERTE 194
Query: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
++ E+FQ L G + P + +Q++ E+ WE L
Sbjct: 195 VLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHP--DLPLIQSKQNEVNAAWERLRGL 252
Query: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
RQ L + Q+++ V + + WI++ + ++ D V E K +
Sbjct: 253 ALQRQKALSNAAN-LQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLER 311
Query: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 3450
+ ++ L + A+ L S +D I++ K + + + + ++ L+ T
Sbjct: 312 NLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQA-TY 370
Query: 3451 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3510
F F + + + + A L++ + + + + + +
Sbjct: 371 WYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSAD 430
Query: 3511 NFTQGLVEDAPDGSDA----SQLLHQAEVAQQEFLEVKQRVNSGCV---MMENKLEGIGQ 3563
Q LV + SD ++L A E + + R C+ + E +
Sbjct: 431 ETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDS 490
Query: 3564 FHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAEC 3623
+ R +E F + DL + L A+ + + + + ++ +D A++
Sbjct: 491 WMSR-QEAFLENEDLGNSLGSAEALLQKHEDFEEAFT-----AQEEKIITVDKTATK--- 541
Query: 3624 RHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLE--LTLGRVEDFYRKLKG-L 3680
L + D +K + L + L E+ R+ L+ L L ++ + LK +
Sbjct: 542 ---LIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI 598
Query: 3681 NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSA 3740
N A++ + +++ + ++ ++F+KE + + +L+ + GQ +I+
Sbjct: 599 NKKKKLADDEDY------KDIQNLKSRVQKQQVFEKE-LAVNKTQLENIQKTGQEMIEGG 651
Query: 3741 GKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEE 3800
D + + E+ + W L + Q+ QL EA +F++ E L WL D E
Sbjct: 652 HYASD--NVTTRLSEVASLWEELLEATKQKGTQLHEANQQL-QFENNAEDLQRWLEDVEW 708
Query: 3801 LIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITG 3860
+ ++ +V + ++++ LL+ + R+ VD+L + D + I
Sbjct: 709 QVTSEDYGKGLAEV-QNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGH-PDSKDIRA 766
Query: 3861 QLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQ 3920
+ ESL R+ L A R+K+L D+L L +T E ++ TE A S +G
Sbjct: 767 RQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDT-EDEEAWIQETEPS-ATSTYLGKD 824
Query: 3921 TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSE 3980
++ + RH+ + E+I +H + + + G + A + V S ++ SL
Sbjct: 825 LIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVAS-RVKSLNQNMES 883
Query: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE---DKLSSVFVKDFKQDVLHRQH 4037
++ R R+ L+ + + D E W+ E E D + ++ +L +
Sbjct: 884 LRARAARRQNDLEANVQFQQYLA-DLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHE 942
Query: 4038 ADHLALNE--EIVNRKKNVDQAIKNGQAL-LKQTTGEEVLLIQEKLDGIKTRYADITVTS 4094
A L LN + + +N A + QA ++ GE+ ++ R ++T+
Sbjct: 943 AFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPR--EVTMKK 1000
Query: 4095 SKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKK 4154
L L + K ++ + G + V ++ P QR++E
Sbjct: 1001 GDVLTLLSSINKDWWKVEAADHQ--GIVPAVYVRRLAH-------DEFPMLPQRRREEPG 1051
Query: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
+ + + + + R+LL+ RA E +L+ NE L++ G ++ I
Sbjct: 1052 NITQRQ---EQIENQYRSLLD----RAEERRRRLLQRYNEF--LLAYEAGDMLEWIQ--- 1099
Query: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDE 4274
++ + EL V E ++K D+ L + DI + D D
Sbjct: 1100 ---EKKAENTGVELDDVWELQKKF----------DEFQKDLNTNEPRLRDINKVAD--DL 1144
Query: 4275 LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE 4334
LF G E + QE L ++ ++ L E+ L A V F +
Sbjct: 1145 LFE------GLLTPEGAQIRQE----LNSRWGSLQRLADEQRQLLGSAHA-VEVFHREAD 1193
Query: 4335 ELSPWIEET-RALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE 4393
+ IE+ +AL A P + Q Q++ E + R+ + P DK+ +G +
Sbjct: 1194 DTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFE-RDLV----PLGDKVTILGETAER 1248
Query: 4394 LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLEN 4453
L+ + E+ Q+ + + E+++ R E+++++ + F K + + +
Sbjct: 1249 LSESHPDATED-LQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISS 1307
Query: 4454 LSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDL 4513
+ + L ++ I + ++ ++E P+F+AL+ ELI A
Sbjct: 1308 IGGMVSSQELAE-DLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHA---- 1362
Query: 4514 AAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHD 4573
+ EI+ KL + +D++ E+R+ K LD + F + + + + ++ +
Sbjct: 1363 -SPEIEKKLQAVKLERDDLEKAWEKRK-KILDQCLELQMFQGNCDQVESWMVARENSLRS 1420
Query: 4574 LESPGIDP--SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4631
+ +D +++K++ + + I + + + F L AD +A K E+ +
Sbjct: 1421 DDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYA-----KEEIATRL 1475
Query: 4632 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4691
+ + W+ L + KL D Y+D L+ + +W+ + C D
Sbjct: 1476 QRVLDRWKALKAQLIDERTKLGDYANLKQFYRD-LEELEEWISEMLPTACDESY--KDAT 1532
Query: 4692 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENL 4751
++ + + + F EV + ++ + + G +++ + + + + ++E L +LK W++L
Sbjct: 1533 NIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHL 1592
Query: 4752 GEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH 4811
E+ + KL A +F ++ + WL+ E LL A + + D L KH
Sbjct: 1593 LERTNDKGKKLNEASRQQ-RFNTSIRDFEFWLSEAETLL-AMKDQARDLASAGNLLKKHQ 1650
Query: 4812 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4871
+L+ ++LA + ++ +N +LL SS + + + + +N+ + +V + ++L
Sbjct: 1651 LLEREMLAREDALKDLNTLAEDLL-SSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKL 1709
Query: 4872 QSTLQQAQGFHSEIEDFLLELTRMESQLS--ASKPTGGLPETAREQLDTHMELYSQLKAK 4929
+ Q F +++D E + +E +L +S+ G + + L H L +L A
Sbjct: 1710 KEAYALFQ-FFQDLDD---EESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAH 1765
Query: 4930 EETYNQLLDKGRLMLLSRDDSGSGSKTEQ-SVALLEQKWHVVSSKMEERKSKLEEALNLA 4988
E +LD + +D + G + Q +A + W + + R KLEE+L
Sbjct: 1766 EPAIQNVLDMAEKL---KDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYL 1822
Query: 4989 TEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQ 5048
QN+ +E W+ + +L + L S + +H+ N+ H ++ +
Sbjct: 1823 QFMQNAEEEEA-WIN-EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCA 1880
Query: 5049 TGNQL--KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKK 5106
G + K L ++ I + + ++ + + + L+D ++F+
Sbjct: 1881 QGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYA-FQEFNWKADV 1939
Query: 5107 LIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKT 5166
+ W+ D E+ L + ++ D + L L+K +L Q + LK+K
Sbjct: 1940 VEAWIADKETSLKTNGNGADLGDFLTL-LAKQDTLDASL---QSFQQERLPEITDLKDKL 1995
Query: 5167 LLPEDSQK--LDNFLGEVRDKWDTVCGKS-------VERQHKLEEALLFSGQFMDALQAL 5217
+ + +Q ++ + +W+ + S +E+Q L++A +F AL
Sbjct: 1996 ISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASAL 2055
Query: 5218 VDWLYKVEPQLAEDQPVH-GDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENS 5276
+W K+E L+E PVH L+ + L H+ F L + + L +++
Sbjct: 2056 NNWCEKMEENLSE--PVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALG 2113
Query: 5277 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQA-------LKQAEVFRDTVHMLLEWL 5329
+ + ++ L W + + ++ L++ + + F L+W+
Sbjct: 2114 VPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
Query: 5330 SEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGE 5378
E + G+L +T L+S ++ +K K+++ + + V +G+
Sbjct: 2174 LET-RAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGD 2221
Score = 156 bits (394), Expect = 7e-37
Identities = 446/2445 (18%), Positives = 939/2445 (38%), Gaps = 294/2445 (12%)
Query: 2517 VQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVS 2576
+QE +L+ +QS +AER L+ + Q + + L + I E L K
Sbjct: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIMEKVNILTDKSYE 82
Query: 2577 SLSSGVIQEALATNMKLKQDI---ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2633
++ IQ + L+ ++ +R S LE TRE +A T A ++ E+
Sbjct: 83 DPTN--IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIE----EL 136
Query: 2634 SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF 2693
++ L EK L + L + + + L+ + ++ +A+ + +D +
Sbjct: 137 RHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEA--IATSVELGED----W 190
Query: 2694 QQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL------DLCQHQDRVQNLRKDFTELQ 2747
++ + L+ + ED Q L E V E++ DL Q + + + L+
Sbjct: 191 ERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLR 250
Query: 2748 KTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSL 2807
+R+K S+ L F++ V +W+KE E + + E K L
Sbjct: 251 GLALQRQKALSNAAN-LQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGL 309
Query: 2808 LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL 2867
+ A V+E+ K L ++ P D
Sbjct: 310 ERNLAVMSDKVKELCAKAEKLT-----LSHPS--------------------------DA 338
Query: 2868 TEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMD 2927
+IQ D+ +E + + R E LQA + + + W+ K + +
Sbjct: 339 PQIQEMKEDLVSSWEHIRALATSRYEKLQATY-WYHRFSSDFDELSGWMNEKTAAI---N 394
Query: 2928 AMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQE 2987
A PT + + ++ E++ + Q E G + N + ++ ++ E
Sbjct: 395 ADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADET--GQDLVNANHEASDEVREKME 452
Query: 2988 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM 3047
L++ W E+ R RQ E+ ++ +E Q+ W+ +E +
Sbjct: 453 ILDNNWTALLELWDERHRQYEQCLDFHLFYRDSE-QVDSWMSRQEAFL------------ 499
Query: 3048 LNAQKQQVQFMLKEFEARRQQHEQLNEA----AQGILTGP-------GDVSLSTSQVQKE 3096
+ + + L EA Q+HE EA + I+T GD + ++
Sbjct: 500 ---ENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAI 556
Query: 3097 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQEL--LQDLSEKVRAVGQRLSVQSAIST 3154
+ + L +K +R + ++++ Y++ L++ K + + + +
Sbjct: 557 RDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNL 616
Query: 3155 QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 3214
+ KQQ+ E E+ + QL++ K Q + + G Y D + RL VA
Sbjct: 617 KSRVQKQQVFE-KELAVNKTQLENIQKTGQEMIE------GGHYASDNVTTRLSEVASLW 669
Query: 3215 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 3274
+ L + + +L A Q F+ ++L+ WL+D + Q L +Q++L+
Sbjct: 670 EELLEATKQKGTQLHEANQQLQ-FENNAEDLQRWLEDVEWQVTSE-DYGKGLAEVQNRLR 727
Query: 3275 ENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGEEKRTLQNQLVELKNHWEELSKKTAD 3333
++ + ++ +++ + P ++ R Q LV +E L + A
Sbjct: 728 KHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLV---CRFEALKEPLAT 784
Query: 3334 RQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 3393
R+ +L D + Q ED WI++ + + + D + + L R + +L +
Sbjct: 785 RKKKLLDLLH-LQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIA 843
Query: 3394 KRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLR 3453
++ + + ++ + + +NQNM+++ + LE Q
Sbjct: 844 SHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQ--- 900
Query: 3454 EFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFT 3513
FQ+ ++ H+ E + N N A +E AL L+
Sbjct: 901 -FQQYLADL--------HEAETWIREKEPIVDNTN---YGADEEAAGAL------LKKHE 942
Query: 3514 QGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCR-VREMF 3572
L++ G L +QA QQ+ Q V E ++ + F R RE+
Sbjct: 943 AFLLDLNSFGDSMKALRNQANACQQQ-----QAAPVEGVAGEQRVMALYDFQARSPREVT 997
Query: 3573 SQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGT 3632
+ D+ L + +I +D +++ D + + ++V R + +E
Sbjct: 998 MKKGDV---LTLLSSINKDWWKVEA--ADHQGIVPAVYV------------RRLAHDE-- 1038
Query: 3633 LDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK-LKGLNDATTAAEEAE 3691
+L +R E G +T+R + + Q L R E+ R+ L+ N+ A E +
Sbjct: 1039 FPMLPQRRREEP-----GNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGD 1093
Query: 3692 ALQWV-------VGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNG-----LGQGLIQS 3739
L+W+ G E++ + + F FQK+ ++ + +L+ +N L +GL+
Sbjct: 1094 MLEWIQEKKAENTGVELDDVWELQKKFDEFQKD-LNTNEPRLRDINKVADDLLFEGLLTP 1152
Query: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
G +E+N+RW +L QR+A Q LL A+E DT+
Sbjct: 1153 EGAQI--------RQELNSRWGSL-----QRLADEQRQLLGSA---HAVEVFHREADDTK 1196
Query: 3800 ELIANQ------KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3853
E I + P ++ V+A + + +R L V +L R+++S A
Sbjct: 1197 EQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDA 1256
Query: 3854 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFH---ETAEPISDFLSVTEKK 3910
E + Q L W +L + R++ L + A++F+ A + +++S +
Sbjct: 1257 -TEDLQRQKMELNEAWEDLQGRTKDRKESLNE----AQKFYLFLSKARDLQNWIS-SIGG 1310
Query: 3911 LANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEK 3970
+ +S+ + I+ + RH+ D+E A L A + +K
Sbjct: 1311 MVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEI-EKK 1369
Query: 3971 IDSLQARYSEIQDRCCRKAALLDQALSNARLFGE-DEVEVLNWLAEVEDKLSSVFVKDFK 4029
+ +++ +++ ++ +LDQ L G D+VE +W+ E+ L S D K
Sbjct: 1370 LQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVE--SWMVARENSLRS----DDK 1423
Query: 4030 QDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTR 4086
+ D L E ++ ++ ++D+AI + + LI ++ + I TR
Sbjct: 1424 SSL------DSL---EALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATR 1474
Query: 4087 YADITVTSSKALRT--LEQARQLA-----TKFQSTYEELTGWLREVEEELATSGGQSPTG 4139
+ + KAL+ +++ +L +F EEL W+ E+ + T
Sbjct: 1475 LQRV-LDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATN 1533
Query: 4140 EQIPQFQQRQKELKKEVMEHRL--VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYK 4197
Q +K LK + H + + V+ V L+ A +G ++ + + EQ K
Sbjct: 1534 IQ-------RKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLK 1586
Query: 4198 LVSDTIGQRVDEIDAAI---QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ 4254
D + +R ++ + R Q++ + W++E + L+A+ +
Sbjct: 1587 EHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAE-TLLAMKDQARDLASAGNL 1645
Query: 4255 LQVQKAFSIDIIRHKDSMDELFSHRSEIF--GTCGEEQKTVLQEKTESLIQQYEAISLLN 4312
L+ + +++ +D++ +L + ++ GT +Q + +K +++ +++ + L
Sbjct: 1646 LKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQ---IVKKKDNVNKRFLNVQELA 1702
Query: 4313 SERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 4372
+ + +L+ A L QF++ ++ WIEE + + D + ++ ++ ++L
Sbjct: 1703 AAHHEKLKEAYALF-QFFQDLDDEESWIEE-KLIRVSSQDYGRDLQGVQNLLKKHKRLEG 1760
Query: 4373 SIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVS 4432
+ H+P I +L + +LK+ E ++ + + + ++KE + R L L+E++
Sbjct: 1761 ELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESL- 1819
Query: 4433 QSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSF 4492
+ Q + ++ E + L+ R + ++ +S ++ E L+ F
Sbjct: 1820 EYLQFMQNAEEEEAWINEKNALAVR-----------GDCGDTLAATQSLLMKHEALENDF 1868
Query: 4493 EALKRR-------GEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLD 4545
+ R GE+++ + ++ KEI K++ + + +++ D
Sbjct: 1869 AVHETRVQNVCAQGEDILNKV--LQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLED 1926
Query: 4546 VLELAEKFW-YDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEE 4604
E W D+ K+T G D + +T+ +E
Sbjct: 1927 DYAFQEFNWKADVVEAWIADKETS---LKTNGNGADLGDFLTLLAKQDTLDASLQSFQQE 1983
Query: 4605 -LEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT----WKERLEK---LEDAM 4656
L I L D + + + + + + WE L + ++ LEK L+ A
Sbjct: 1984 RLPEITDL-KDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
Query: 4657 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4716
V++ A+ +W + L + P LN ++ + ++F + + Q + +
Sbjct: 2043 DLFVEFAHKASALNNWCEKMEENL-SEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKC 2101
Query: 4717 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGA-------LLAL 4769
L + + KA + L+ W++L + I R+ +L+
Sbjct: 2102 LLELDQQI--KALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMC 2159
Query: 4770 GQFQHALEELMSWLTHTEE-LLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
+F+ + W+ T LD + + +E +L + + ++ A + + +
Sbjct: 2160 QEFEQNASTFLQWILETRAYFLDGS--LLKETGTLESQLEANKRKQKEIQAMKRQLTKIV 2217
Query: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQS 4873
G+ L ++ D S + +Q ++ L+ EQQ+Q+
Sbjct: 2218 DLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQA 2262
Score = 137 bits (346), Expect = 2e-31
Identities = 187/903 (20%), Positives = 385/903 (42%), Gaps = 60/903 (6%)
Query: 4626 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685
E+++ E+ +++ + ER +KLED+ V +D + W+ V L
Sbjct: 23 EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDA-DDLGKWIMEKVNILTDKSY 81
Query: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQI-EMEKLNHQGELMLKKATDETDRDIIREPLTEL 4744
K Q ++ E +V+ + + E+EK + M A +ET I EL
Sbjct: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI-----EEL 136
Query: 4745 KHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIE 4804
+HLW+ L E + +L AL Q+ +++ W+ E + + + D + E
Sbjct: 137 RHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIGDKEAIATSVE-LGEDWERTE 194
Query: 4805 VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKT 4864
V K + +++A + V VN+ NE E + D ++S+ +N WE +
Sbjct: 195 VLHKKFEDFQVELVAKEGRVVEVNQYANECAEENH-PDLPLIQSKQNEVNAAWERLRGLA 253
Query: 4865 EEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL-DTHMELY 4923
+R++ L S Q F ++ + + + E L++ G A E L +H L
Sbjct: 254 LQRQKAL-SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDY--GKDLVASEGLFHSHKGLE 310
Query: 4924 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983
L + +L K + LS + ++ L W + + R KL+
Sbjct: 311 RNLAVMSDKVKELCAKAEKLTLSHPSDAP--QIQEMKEDLVSSWEHIRALATSRYEKLQ- 367
Query: 4984 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVLSQIEEHKVFANEVNAHRD 5041
A F + E W+ ++N P+ + +L + ++HK +E++++ D
Sbjct: 368 ATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHK---HEIDSYDD 424
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 5101
+ D+TG L + + + + + + + + W +++ ER R + F+
Sbjct: 425 RFQSADETGQDLVNANHEASDEVREKMEI-LDNNWTALLELWDERHRQYEQCLD-FHLFY 482
Query: 5102 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRA 5161
+++ W+ E+ L++E ++ N + L KH++F++ ++ T +T
Sbjct: 483 RDSEQVDSWMSRQEAFLENE-DLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
Query: 5162 LKEKTLLPEDSQKLDNFLGEVRD----KWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
L + +D +N + +RD + D + K+ R+ L+E+LL + D+ L
Sbjct: 542 L-----IGDDHYDSEN-IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDS-DDL 594
Query: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277
+W+ K + +LA+D+ + D+ + + + +VF+KEL ++ ++++G+E+IE
Sbjct: 595 KNWINK-KKKLADDED-YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGH 652
Query: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
+ V +L E+++ W+ + + + K ++L +A +Q + F + L WL + E +
Sbjct: 653 YASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ-FENNAEDLQRWLEDVEWQVT 711
Query: 5338 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 5397
E +Q+ + H V ++ V+ + + HPD
Sbjct: 712 SEDYGKGLAE-VQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDS--------K 762
Query: 5398 IIRARFEEVLTWAKQHQQRLETALSELVANAEL------LEELLAWIQWAETTLIQRDQE 5451
IRAR E ++ + ++ L T +L+ L E+ AWIQ E +
Sbjct: 763 DIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPS---ATST 819
Query: 5452 PIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKS 5511
+ +++ K L+ H+ +E + +P + +T+ K +E H F + + KS
Sbjct: 820 YLGKDLIASKKLLNRHRVILENIASHEPRIQEITER-GNKMVEEGH--FAAEDVASRVKS 876
Query: 5512 LSQ 5514
L+Q
Sbjct: 877 LNQ 879
Score = 75.1 bits (183), Expect = 2e-12
Identities = 230/1220 (18%), Positives = 451/1220 (36%), Gaps = 187/1220 (15%)
Query: 1800 RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVS 1859
R+ L +K +LS R+++ I + + +DL +LER + + +
Sbjct: 1281 RKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA 1340
Query: 1860 -----QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914
Q LE + +I ++ K L+ A L++ + W R +E
Sbjct: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQ--AVKLERD--DLEKAWEKRKKILDQCLE 1396
Query: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMA 1974
++ +G + +W+ + NS S+ + +DSL +++ +DL + +
Sbjct: 1397 LQ---------MFQGNCDQVESWMVARE---NSLRSDDKSSLDSLEALMKKRDDLDKAIT 1444
Query: 1975 ERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGH 2034
++ ++ D++ F A+ L ++ + LQR +L++ A L
Sbjct: 1445 AQEGKIT----DLEHF----AESLIADEHYAKEEIATRLQR----VLDRWKALKAQLIDE 1492
Query: 2035 LQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
++ A +K ++ LE+L W+ + + +D + +Q+
Sbjct: 1493 RTKLGDYANLKQF-------YRDLEELEEWISEMLPTACDE----SYKDATNIQRKYLKH 1541
Query: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRV 2154
+ ++ R+ V+ +E + + A++E+L Q KE ++ L E T
Sbjct: 1542 QTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE---AMKEQLEQLKEHWDHLLERTND 1598
Query: 2155 AQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQL 2214
K+L EA S Q+ + + + + A+ D + S+G NL QL
Sbjct: 1599 KGKKLNEA--SRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAG-----NLLKKHQL 1651
Query: 2215 SGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 2274
LE+ L D +N E L +++ ++ N + Q
Sbjct: 1652 ----LEREMLAREDALKDLNTLAEDLLSSGTF---NVDQIVKKKDNVNKRFLNVQELAAA 1704
Query: 2275 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLE 2334
H +LKE Y+ L +F QD + ESW+E
Sbjct: 1705 HHE---------------KLKEAYA-------------------LFQFFQDLDDEESWIE 1730
Query: 2335 RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE- 2393
+ + G + + +LLK+ ++++H+ + Q VLDM K+
Sbjct: 1731 EKLIRVSSQDYGRDL-QGVQNLLKKHKRLEGELVAHEPAI-------QNVLDMAEKLKDK 1782
Query: 2394 ---GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWM 2450
G+E ++ +L E + L G L L +Y QF +A+ +AW+
Sbjct: 1783 AAVGQEEIQL------RLAQFVEHWEKLKELAKARGLKLEESL-EYLQFMQNAEEEEAWI 1835
Query: 2451 QACEA-NVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGE 2509
A V DT+A+ +L + A L+ + A H+ V+ + DI+ +
Sbjct: 1836 NEKNALAVRGDCGDTLAATQSLLMKHEA----LENDFAVHETRVQNVCAQGEDILNKVLQ 1891
Query: 2510 PAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569
++ + +++ SL+ ++A L+ A Q + + I + E +
Sbjct: 1892 EESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYA-FQEFNWKADVVEAWIADKETS 1950
Query: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIAR-QKSSLEATREMVTRFMETADSTTAAVLQG 2628
L+ + G LA L + Q+ L ++ + + + + A+ +
Sbjct: 1951 LKTNG-NGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAI-EE 2008
Query: 2629 KLAEVSQRFEQLC-LQQQEKESSLKKLLPQAEM------FEHLSGKLQQFMENKSRMLAS 2681
+ A + +R+EQL ++ L+K LP + F H + L + E L+
Sbjct: 2009 RYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLS- 2067
Query: 2682 GNQPDQDITHFFQQIQELNLEMED-------QQENLDTLEHLVTELSSCGFALDLCQHQD 2734
+P ++ +I++L + ED Q + L L ++ + G
Sbjct: 2068 --EPVHCVS--LNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLT 2123
Query: 2735 RVQNLRKDFTELQKTVKEREKDASSCQ-------EQLDEFRKLVRTFQKWLKETEGSIPP 2787
V+ L + + L ++ERE++ + E EF + TF +W+ ET
Sbjct: 2124 -VEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLD 2182
Query: 2788 TETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSI 2847
LE Q+E K + + + +I G +LE+ + I
Sbjct: 2183 GSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDAL--------------I 2228
Query: 2848 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE--- 2904
L S++G + L + ++ + + GV E + I +E
Sbjct: 2229 LDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLT 2288
Query: 2905 ---VHKEANSVLQWL----------ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAE 2951
HKE S L+ L E + + K +DA+ K E AFL +
Sbjct: 2289 GRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKG---YVSLEDYTAFLID 2345
Query: 2952 LE----QNSPKIQKVKEALA 2967
E ++S +I+ +ALA
Sbjct: 2346 KESENIKSSDEIENAFQALA 2365
Score = 39.3 bits (90), Expect = 0.12
Identities = 57/294 (19%), Positives = 123/294 (41%), Gaps = 39/294 (13%)
Query: 5264 VLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 5323
V++ SG +++E + + ++ + QE+ TR+ + + + +LE + +VF+
Sbjct: 9 VVESSGPKVLETAEE----IQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDAD 63
Query: 5324 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAV 5383
L +W+ E L + +D +Q H+ +V+ K ++ E +
Sbjct: 64 DLGKWIMEKVNILTDKSY--EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTM 121
Query: 5384 CHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAET 5443
H T H I +R ++ +L + +L AL + + ++L WI E
Sbjct: 122 GHSAHEETKAH-IEELRHLWDLLLELTLEKGDQLLRAL-KFQQYVQECADILEWIGDKEA 179
Query: 5444 TLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK 5503
+ + ++ +R + L + + F E+ K+ V V + Y + E H
Sbjct: 180 IATSVE---LGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQ-YANECAEENH------ 229
Query: 5504 SRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDA 5557
P +P++ + N+++A W+++ LAL+RQ+ L++A
Sbjct: 230 --------------PDLPLIQSKQ------NEVNAAWERLRGLALQRQKALSNA 263
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 171 bits (434), Expect = 2e-41
Identities = 642/3239 (19%), Positives = 1234/3239 (38%), Gaps = 488/3239 (15%)
Query: 1874 QEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD 1933
QE+ QL K L+K+ + Q L S+ + L + VE EKT+ N + + ++
Sbjct: 21 QELEGQLDK-LKKEKQQRQFQLDSLE----AALQKQKQKVENEKTEGTNLKRENQRLMEI 75
Query: 1934 LRAWVGNKNLI---LNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLD-----ALAF 1985
+ K I L K S LN +Q E L+Q + K++L+ A +
Sbjct: 76 CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSA 135
Query: 1986 DIQFFISEHAQD-----LSPQQNRQMLRLLNELQRSFQDILEQTA--AQVDALQGHLQQM 2038
D+ Q L+P Q + + ++ +++ E+ A+V ALQ ++
Sbjct: 136 DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQA--KKA 193
Query: 2039 EQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQ 2098
Q T+ + HQ + SW Q E+ H +Q+ + S Q
Sbjct: 194 SQTLPQATMNHRDIARHQASSSVFSW--QQEKT-PSHLSSNSQRTPIRRDFSASYFSGEQ 250
Query: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKE 2158
+ +R+T +D +N + SP L L+ + + + + L+ + +KE
Sbjct: 251 EVTPSRST-LQIGKRDANSSFFDNSS--SPHLLDQLKAQNQELRNKINELELRLQGHEKE 307
Query: 2159 LEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGAS 2218
++ V + + + KA EL E +K ++ D + + Q T +EQ
Sbjct: 308 MKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ----K 363
Query: 2219 LEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHN 2278
L+K D + A L+++ + + QE LS+QQ + Q+ Q
Sbjct: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR---SFQTLDQECIQMKAR 420
Query: 2279 LTPEEQQ------MLQQKLGELK----------EQYSTSLAQSEAELKQVQTLQDELQKF 2322
LT E QQ +LQ +L +L E++ L ++E + Q ++EL++
Sbjct: 421 LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRS 480
Query: 2323 LQDHKEFESWLE-RSEKELENMHKGGSSPETLPSLLKRQGSFSEDV-ISHKGDLRFVTIS 2380
+++ K+ + L+ SE++ + + + + L + +F+E++ + +
Sbjct: 481 MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL 540
Query: 2381 GQKVLDMENSFKEGKEPSEIGNLVK------DKLKDATERYTALHSKCTR-------LGS 2427
+K+ ENS K + +L K D LK L+ K ++ L S
Sbjct: 541 QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS 600
Query: 2428 HLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELA 2487
L + +Y + + W ++ EKLL+ + S+ LQ ++ L+ L
Sbjct: 601 ALELKKKEYEELKEEKTLFSCW----KSENEKLLTQ-MESEKENLQSKI---NHLETCLK 652
Query: 2488 EHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD--SILSHFQSLSYSLAERSSLLQKA 2545
Q+ + + R + + + R++ D S+ Q L+Y L QKA
Sbjct: 653 TQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAY-----MELQQKA 707
Query: 2546 IAQSQSVQESLESLL----QSIGEVEQNLEGKQVSSLSSGVIQ-----EALATNMKLKQD 2596
Q Q+ +E++ Q G+VE +LE K + LS+ ++ + L + +D
Sbjct: 708 EFSDQKHQKEIENMCLKTSQLTGQVE-DLEHK-LQLLSNEIMDKDRCYQDLHAEYESLRD 765
Query: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
+ + K + T E R + D A + F + +Q S +
Sbjct: 766 LLKSKDASLVTNEDHQRSLLAFDQQPA---------MHHSFANIIGEQGSMPSERSECRL 816
Query: 2657 QAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHL 2716
+A+ S LQ +++ L S Q + D+ +++ ++ E+E ENL E +
Sbjct: 817 EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE---ENLMKAEQM 873
Query: 2717 VTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQK 2776
+ + R+ L++D + Q V E + +++L V T Q
Sbjct: 874 HQSF--------VAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQA 925
Query: 2777 WLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEIT 2836
++E + S E S+ KEL+ E L + +S +L + + T + EI
Sbjct: 926 EIQELKKSNHLLEDSL--KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEIN 983
Query: 2837 APDSQGKTGSILPSVG---------SSVGSVNGYHTCKDLTEIQ-CD-----MSDVNLKY 2881
A +Q K I S S+ ++ + + L +Q C+ D++ KY
Sbjct: 984 ASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKY 1043
Query: 2882 EKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQ 2941
+ E+ L+ +LN E S+ + +++ E LK A +
Sbjct: 1044 K----AAQEKNSKLECLLN-------ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFA 1092
Query: 2942 AESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAE------NWKKIQEELNSRWER 2995
E N+ + ELE V++AL + N+ ++E ++EE N +
Sbjct: 1093 EERNQNLMLELE-------TVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKE 1145
Query: 2996 ATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGV--------LGPLSIDPNM 3047
++ ++ ++ + C +R + E+E L I +
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDS 1205
Query: 3048 LNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL-TGPGDVSLSTSQ--VQKELQSINQKW 3104
NAQ Q++ ML+ E + Q+ E+ E Q L T GD+ S Q +E+ +
Sbjct: 1206 YNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCE 1265
Query: 3105 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 3164
++ +K S ++ + + Q LQ K+ + + + A + E V + +
Sbjct: 1266 IDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQA--EKYELVTELND 1323
Query: 3165 ETSE----IRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL 3220
SE R E++ + E + L D+ +L GE ++D +
Sbjct: 1324 SRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGE-LVEDIPGGEFGEQPNEQHPVSLA 1382
Query: 3221 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQA----KNCPISAKLERLQSQLQEN 3276
D N + S ++ Q F EL+ QS+ ++C +S+K+ LQ+ +
Sbjct: 1383 PLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDS- 1441
Query: 3277 EEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 3336
+ E+L+LS R Q LV+ + Q
Sbjct: 1442 ------------------LKAENLVLST----NLRNFQGDLVK-------------EMQL 1466
Query: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRR 3396
L+ E LVP + S +L +LL ++ +
Sbjct: 1467 GLE-------------EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLE 1513
Query: 3397 SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ 3456
+ + D + SS +E+ R E T AK +EE+ ++
Sbjct: 1514 GAVSANQCSVDEVFCSSLQEENLTRKE-----------TPSAPAK--GVEELESLCEVYR 1560
Query: 3457 ESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGL 3516
+S + +E+K+E NK +++L +++L + ++D LR
Sbjct: 1561 QSLEKLEEKME------------SQGIMKNKEIQEL---EQLLSSERQELDCLR------ 1599
Query: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA 3576
Q L + E QQ+ V + S + + E Q + QL
Sbjct: 1600 ----------KQYLSENEQWQQKLTSVTLEMESKLAAEKKQTE---QLSLELEVARLQLQ 1646
Query: 3577 DLDDELDGMGAIGRDT-DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3635
LD L +G DT D++Q + E ++K H + + + + +++ D
Sbjct: 1647 GLD--LSSRSLLGIDTEDAIQGRNESCD--ISKEHTSETTERTPKHDVHQICDKDAQQD- 1701
Query: 3636 LGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW 3695
LN K+TE G + E + + D + G D T + E +
Sbjct: 1702 ---------LNLDIEKITETGAVKPTG-ECSGEQSPDTNYEPPG-EDKTQGSSECISELS 1750
Query: 3696 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAGKDCDVQGLEHDME 3754
G + L + +E + LQ+++++ + L+ +D V+ L ++M+
Sbjct: 1751 FSGPNALVPMDFLGN-----QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805
Query: 3755 EINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKV 3814
E L+ K+ + QL + C + + + L +D E K+
Sbjct: 1806 E-------LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSE------------KL 1846
Query: 3815 VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL-- 3872
Q+LLQR V+ + + A+ + RE I + + W E
Sbjct: 1847 EYFSCDHQELLQR--------VETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFL 1898
Query: 3873 -----LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQ 3927
LS+ + + +E HE +D V +KL + + +Q+
Sbjct: 1899 DVENELSRIRSEKASIE---------HEALYLEADLEVVQTEKLCLE-----KDNENKQK 1944
Query: 3928 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
+I LEE++ ++ +Q ++S T+ +Q LSEK+ Q C
Sbjct: 1945 VI--VCLEEELSVVTSERNQLRGELDTMSKKTTALDQ--LSEKMKEKTQELESHQSECL- 1999
Query: 3988 KAALLDQALSNARLFGEDEVEVLNWL-AEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046
+ A +++ E+L L ++V + L K Q+ L D AL+
Sbjct: 2000 ------HCIQVAEAEVKEKTELLQTLSSDVSELLKD---KTHLQEKLQSLEKDSQALSLT 2050
Query: 4047 IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR-TLEQAR 4105
+ + Q K + L+K++ + L + + + SKAL L +
Sbjct: 2051 KCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNV---------SKALEAALVEKG 2101
Query: 4106 QLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDT 4165
+ A + ST EE+ R +E+ I + +LK+ E+ + D
Sbjct: 2102 EFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAE------KLKERERENDSLKDK 2155
Query: 4166 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 4225
V + R L + E + ++ DA E K +T+ +++E+ +++ +
Sbjct: 2156 VENLEREL-----QMSEENQELVILDA-ENSKAEVETLKTQIEEMARSLKVFE------- 2202
Query: 4226 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285
+ L +R E++ T Q+Q ++ ++ + S L + +
Sbjct: 2203 -------------LDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Query: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
EE KT ++ L + EA++ L ++ + +A T + L P IEE
Sbjct: 2250 IKEESKTAVEMLQNQLKELNEAVAALCGDQ--EIMKA---------TEQSLDPPIEE--- 2295
Query: 4346 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 4405
QLR E++R E A+ K K L + QLKE + ++++
Sbjct: 2296 -----------EHQLRNSIEKLRARLE--ADEK----KQLCVLQQLKE-SEHHADLLK-- 2335
Query: 4406 YQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIP 4465
+ EN+ +++ + A EA + ++ KIE M ++L L + I
Sbjct: 2336 -GRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV---VTIR 2391
Query: 4466 AEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE-IQDKLDQ 4524
+E + + + + ELE + SFE + + E+ + Q +K A E +Q +L +
Sbjct: 2392 SEKENLTNELQKEQERISELEIINSSFENILQEKEQ--EKVQMKEKSSTAMEMLQTQLKE 2449
Query: 4525 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4584
+ + E + K ++ E + A LL + + ++ L+S +
Sbjct: 2450 LNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS------V 2503
Query: 4585 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI-DEMNNAWENLNK 4643
++ E K++ + EE+ ++ D + + E + E N NL
Sbjct: 2504 NGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV 2563
Query: 4644 TWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNT-----------VIKLCTMPPVGTDLNT 4692
+++++ L+ + + LQ+ + L+N V K+ M T+L
Sbjct: 2564 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETEL-- 2621
Query: 4693 VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLG 4752
+ +++EM + E+ Q+++ EK GEL L ++ +D ++E E L ++L
Sbjct: 2622 -QREMHEMAQKTAEL-QEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLD 2679
Query: 4753 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH- 4811
+ K + ++Q L E H LLD K EVE+ +
Sbjct: 2680 CMHKDQVEKEGKVREEIAEYQLRLHEAEK--KHQALLLDTN-------KQYEVEIQTYRE 2730
Query: 4812 --VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLR--SRLEAMNQCWESVLQKTEER 4867
K + L+ Q + K+ E L +S L + + N + + L+K ER
Sbjct: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENER 2790
Query: 4868 EQ-QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHM-ELYSQ 4925
Q +++ ++ + E E EL+++++ K TG + +T ++L T + EL
Sbjct: 2791 AQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK-TGTVMDTKVDELTTEIKELKET 2849
Query: 4926 LKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLE-QKWHVVS--SKMEERKSKL 4981
L+ K + ++ LDK +L+S + K E++ +LE Q H+ S SK + R S L
Sbjct: 2850 LEEKTKEADEYLDKYCSLLISHE------KLEKAKEMLETQVAHLCSQQSKQDSRGSPL 2902
Score = 144 bits (363), Expect = 3e-33
Identities = 594/3001 (19%), Positives = 1173/3001 (39%), Gaps = 536/3001 (17%)
Query: 1119 STLKVLEAQANTGGIIDTATGKRLTLASALEEKL---VDENMVRIIASHQVLNGGIVDIF 1175
STL++ + AN+ ++++ L A ++L ++E +R+ H+ G V+ F
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRL-QGHEKEMKGQVNKF 315
Query: 1176 SDQRVTL----VEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGK 1231
+ ++ L VE IEK + + + + ++++ Q + AL+ +
Sbjct: 316 QELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD--------QASTKYTALEQKLKKL 367
Query: 1232 DMLIACN-QTAEMS-CN---KVEESERLFQVENQSAQE----------KVKVRVSDG-EQ 1275
++C Q AE + C+ K++E E+ FQ E Q ++K R++ +Q
Sbjct: 368 TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427
Query: 1276 AKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLK 1335
AK + E K ++ ++ +EF + + + Q S +E ++
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL----CRAEQAFQASQIKE-NELRRSME 482
Query: 1336 EVAR-NNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETS 1394
E+ + NN+ +E++ + V +E + +K CL+ + + ++ + T ET
Sbjct: 483 EMKKENNLLKSHSEQKAREVCHLE--AELKNIKQCLNQSQNFAEE----MKAKNTSQETM 536
Query: 1395 GKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIK 1454
+ E++ QQ + ++ + K V E R C L + + + E + D+ K
Sbjct: 537 LRDLQEKINQQENSLTLE--KLKLAVADLEKQRDCSQDLLKKREHHIEQ-LNDKLSKTEK 593
Query: 1455 SQPREMTSSEKGKEADTEMGFSIT-FKIEESSSQVVPQGISVKHLDALTLFSSKQAN-EG 1512
+++ E K+ E+ T F +S ++ + LT S++ N +
Sbjct: 594 ESKALLSALELKKKEYEELKEEKTLFSCWKSENEKL-----------LTQMESEKENLQS 642
Query: 1513 KVNNLSLCL---------------TLKPE-ENLSREIACGAQSEPFPCMTPRPEGLHYQE 1556
K+N+L CL TL+ + ENLS EI + + L Y E
Sbjct: 643 KINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME 702
Query: 1557 SDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISS-SNEC--KEKSY 1613
KA+ + + + T++ +T + ++ +H++ SNE K++ Y
Sbjct: 703 LQQKAEFSDQKHQKEIENMCLKTSQ---------LTGQVEDLEHKLQLLSNEIMDKDRCY 753
Query: 1614 QEV--SFDPARGL-KLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIA 1670
Q++ ++ R L K ++ ++ + + L F + +HH +
Sbjct: 754 QDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFAN-------------- 799
Query: 1671 TQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNA 1730
+ GE+ + + LEA + + S +L + + F SQK+
Sbjct: 800 ---IIGEQGSMPSERSECRLEADQ-----SPKNSAILQNRVDSLEFSLESQKQMNSD--- 848
Query: 1731 IISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEP 1790
L+ E+ V + ++ E++ +S +E + ++ + E
Sbjct: 849 ------LQKQCEELVQIK--GEIEENLMKAEQMHQSFVAETSQRISKLQ---------ED 891
Query: 1791 FRATQNVFTRQL-CLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLER 1849
A QNV L LE+ EK + L+ +E +IQ L+ + L+D L + ++L
Sbjct: 892 TSAHQNVVAETLSALENKEKELQLLN--DKVETEQAEIQELKKSNHLLEDSLKELQLLSE 949
Query: 1850 EL----KDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNL---QKSLSSVSDTW 1902
L K++++++S + ++ +Q ++ +L ++ NL +S ++ D
Sbjct: 950 TLSLEKKEMSSIISLNKREIEEL--TQENGTLKEINASLNQEKMNLIQKSESFANYIDER 1007
Query: 1903 NSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC 1962
+ + + EK +L + + +DL K K S E LN C
Sbjct: 1008 EKSISELSDQYKQEKLILLQRCEETGNAYEDL----SQKYKAAQEKNSKLEC---LLNEC 1060
Query: 1963 LQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILE 2022
E+ K + + K +A A + Q F+++ A + ++N+ ++ L +Q++ + +
Sbjct: 1061 TSLCENRKNELEQLK---EAFAKEHQEFLTKLA--FAEERNQNLMLELETVQQALRSEMT 1115
Query: 2023 QTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQ 2082
+ G L+Q + TL+++QN +++ DL +
Sbjct: 1116 DNQNNSKSEAGGLKQE-----IMTLKEEQNKMQKEVNDLLQ----------------ENE 1154
Query: 2083 DLSALQKNQSDLKDLQDD-IQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQA 2141
L + K + + ++L+ + I+N VK+ E E NQ P+ ++E +
Sbjct: 1155 QLMKVMKTKHECQNLESEPIRNS-------VKERES--ERNQCNFKPQMDLEVKEI---S 1202
Query: 2142 KEQYEA--LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGS 2199
+ Y A +Q E + KEL+ QE+EK K L + I L+
Sbjct: 1203 LDSYNAQLVQLEAMLRNKELK-------LQESEKEKEC--LQHELQTIRGDLE------- 1246
Query: 2200 SGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQ 2259
+NL M+ + L+ +D + Y+ H+ SQ
Sbjct: 1247 -----TSNLQDMQSQEISGLKDCEIDAEEKYIS----------------GPHELSTSQND 1285
Query: 2260 NFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAE-LKQVQTLQDE 2318
N L Q L + L E + + + L K + T L S +E + + + +E
Sbjct: 1286 NAHL-----QCSLQTTMNKLN--ELEKICEILQAEKYELVTELNDSRSECITATRKMAEE 1338
Query: 2319 LQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVT 2378
+ K L + K EL GG E Q S + +T
Sbjct: 1339 VGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQP----NEQHPVSLAPLDESNSYEHLT 1394
Query: 2379 ISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ 2438
+S ++V + F E +++K + LH + ++ S ++ L
Sbjct: 1395 LSDKEV---QMHFAE----------LQEKFLSLQSEHKILHDQHCQMSSKMSEL------ 1435
Query: 2439 FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQK 2498
Q DSL+A N+ D V K++Q L E VP
Sbjct: 1436 -QTYVDSLKAENLVLSTNLRNFQGDLV--------------KEMQLGLEEGLVP------ 1474
Query: 2499 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSL--LQKAIAQSQ-SVQES 2555
+ PD + DS S +++L + S L L+ A++ +Q SV E
Sbjct: 1475 ------SLSSSCVPDSSSLSSLGDS--SFYRALLEQTGDMSLLSNLEGAVSANQCSVDEV 1526
Query: 2556 LESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
S LQ E+NL K+ S + ++E +S E R+ + +
Sbjct: 1527 FCSSLQ-----EENLTRKETPSAPAKGVEEL--------------ESLCEVYRQSLEKLE 1567
Query: 2616 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENK 2675
E +S +++ K E+ + + L ++QE + K+ L + E ++ + +E +
Sbjct: 1568 EKMESQ--GIMKNK--EIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVT--LEME 1621
Query: 2676 SRMLASGNQPDQ---DITHFFQQIQELNLE------------MEDQQENLDTLEHLVTEL 2720
S++ A Q +Q ++ Q+Q L+L ++ + E+ D + +E
Sbjct: 1622 SKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSET 1681
Query: 2721 SSCGFALDLCQ--HQDRVQNLRKDFTELQKTVKEREKDASSCQEQLD-----EFRKLVRT 2773
+ D+ Q +D Q+L D ++ +T + S ++ D +
Sbjct: 1682 TERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQG 1741
Query: 2774 FQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKG-TLVEEINCKGTSLENLI 2832
+ + E S P M ++ I +L+ + + +++ L+ I + +E+L+
Sbjct: 1742 SSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLL 1801
Query: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKY-EKLGGVLHER 2891
E+ DS+ V + C +L +I ++ N EKL +
Sbjct: 1802 NEMKELDSKLHL--------QEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853
Query: 2892 QESLQAI-----LNRMEEVHKEANS-------VLQWLESKEEVLKSMDAMSSPTKTETVK 2939
QE LQ + LN E+H + +S V + +S +E + +D + ++ + K
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE--RFLDVENELSRIRSEK 1911
Query: 2940 AQAESNKAFLAE-----------LEQNSPKIQKVKEALAGLL--VTYPNSQ---EAENWK 2983
A E +L LE+++ QKV L L VT +Q E +
Sbjct: 1912 ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMS 1971
Query: 2984 KIQEELNSRWERATEVTVARQRQLEESASH-LACFQAAESQLRPWLMEKELMMGVLGPLS 3042
K L+ E+ E T ++LE S L C Q AE++++ EK +L LS
Sbjct: 1972 KKTTALDQLSEKMKEKT----QELESHQSECLHCIQVAEAEVK----EK---TELLQTLS 2020
Query: 3043 IDPNMLNAQKQQVQFMLKEFEARRQ-----QHEQLNEAAQGILTGPGDVSLSTSQVQKEL 3097
D + L K +Q L+ E Q + E N+ AQ ++ + KE
Sbjct: 2021 SDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQ--------LNKEKELLVKES 2072
Query: 3098 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ-----RLSVQSAI 3152
+S+ + E + + S ++ A+V+ ++ L E+V + + R+ +++
Sbjct: 2073 ESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132
Query: 3153 STQ---PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE------QYLK--- 3200
Q E +K++ E ++ +E L+ E++ ++ EL +L E + LK
Sbjct: 2133 KKQLHIAEKLKERERENDSLKDKVENLERELQMSEE-NQELVILDAENSKAEVETLKTQI 2191
Query: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
+E+ + L+ L L L + ++Q + ++ ++ L++K+ + +
Sbjct: 2192 EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIK 2251
Query: 3261 PIS-AKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVE 3319
S +E LQ+QL+E E +L G E++ A +SL PP EE+ L+N + +
Sbjct: 2252 EESKTAVEMLQNQLKELNEAVAAL---CGDQEIMKATEQSL---DPPIEEEHQLRNSIEK 2305
Query: 3320 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL---------------------VPW 3358
L+ E KK +LK+ A + VE+L
Sbjct: 2306 LRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGE 2365
Query: 3359 IEDCKAKMSELRVTLDPVQLESSLLRSKA--MLNEVEK---RRSLLEILNSAADILINSS 3413
+E KAK+ + +L ++L+ +RS+ + NE++K R S LEI+NS+ + ++
Sbjct: 2366 VETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEK 2425
Query: 3414 EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL 3473
E EK + + E LQ + L E L QE+ K E+ + L
Sbjct: 2426 E-------QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL 2478
Query: 3474 EIFDA-------------LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA 3520
E+ A + Q+ N ++++ ++ L+ + ++ L+N Q +
Sbjct: 2479 ELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV 2538
Query: 3521 PDGSDAS------------------------QLLHQAEVAQQEFLEVKQRVNSGCVMMEN 3556
S Q+L + Q+ LEV Q S +EN
Sbjct: 2539 SKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQ---SSYKNLEN 2595
Query: 3557 KLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTDSLQSQIE-DVRLFLNKIHVLKL 3614
+LE E +++ + EL M + + T LQ ++ + ++ +L
Sbjct: 2596 ELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE 2655
Query: 3615 DIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFY 3674
+I++S+ + + + TL+ LK+ L+ ++K ++ + GK R+E E L R+ +
Sbjct: 2656 EIKSSKDQLKEL-----TLENSELKKSLDCMHKD--QVEKEGKVREEIAEYQL-RLHEAE 2707
Query: 3675 RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ 3734
+K + L T E E + T E + + + QK ++D L+ +++N +
Sbjct: 2708 KKHQALLLDTNKQYEVE-----IQTYREKLTSK-EECLSSQKLEIDLLKSSKEELNNSLK 2761
Query: 3735 GLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSW 3794
Q ++ L+ + N L K+ + +++ + C + ++ E L
Sbjct: 2762 ATTQI------LEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKE 2815
Query: 3795 LADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELAD 3854
L+ + QK + V E K L+ L+++ D + + L
Sbjct: 2816 LSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDK-----YCSLLIS 2870
Query: 3855 REKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANS 3914
EK+ E LE++ L S+ + + + +L S SVTEK+L++
Sbjct: 2871 HEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLL------GPVVPGPSPIPSVTEKRLSSG 2924
Query: 3915 E 3915
+
Sbjct: 2925 Q 2925
Score = 85.9 bits (211), Expect = 1e-15
Identities = 237/1123 (21%), Positives = 453/1123 (40%), Gaps = 222/1123 (19%)
Query: 4058 IKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKAL--RTLEQARQLATKFQSTY 4115
I N Q +K+T+ E + L+ D + R + + K L + Q QL TK ++
Sbjct: 1769 IHNLQLRVKETSNENLRLLHVIED--RDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI 1826
Query: 4116 E--ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 4173
E ++ G L++ +L+ E++ F +EL + V +T ++ L
Sbjct: 1827 ELEKIVGELKKENSDLS---------EKLEYFSCDHQELLQRV-------ETSEGLNSDL 1870
Query: 4174 LELVPWRAREGLDKLVSDANEQYK---LVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 4230
+RE + V+ N+ +K L + R+ A+I+ Y +A D E+
Sbjct: 1871 EMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEA-DLEVVQ 1929
Query: 4231 VA--------ETKRKLMA-----LGPIRLEQDQTTAQLQV--QKAFSIDII--RHKDSMD 4273
E K+K++ L + E++Q +L +K ++D + + K+
Sbjct: 1930 TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ 1989
Query: 4274 ELFSHRSE-----------------IFGTCGEE------QKTVLQEKTESLIQQYEAISL 4310
EL SH+SE + T + KT LQEK +SL + +A+SL
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSL 2049
Query: 4311 -----------LNSERYARLERAQVLVNQFWET-YEELSPWIEETRALIAQLPSPAIDHE 4358
LN E+ ++ ++ L + E+ YE+L+ ++AL A L
Sbjct: 2050 TKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNV----SKALEAALVEKGEFAL 2105
Query: 4359 QLRQQQEEMRQLRESIAEHKPHID----KLLKIGPQLKELNPEEGEMVEEKYQKAENMYA 4414
+L QEE+ QLR I + + I+ K L I +LKE E + + K EN+
Sbjct: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD----KVENLER 2161
Query: 4415 QIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIREC 4474
+++ + L + +A + ++ +IE M +L+ L + +E + + +
Sbjct: 2162 ELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDL---VTLRSEKENLTKQ 2218
Query: 4475 ISDNKSATVELEKLQPSFEAL-----------KRRGEELIGRSQGADKDL---------- 4513
I + + EL+KL SF++L K + + Q K+L
Sbjct: 2219 IQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGD 2278
Query: 4514 --AAKEIQDKLD-------QMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTI 4564
K + LD Q+ E ++AR E E K L VL+ ++ + L +
Sbjct: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 2338
Query: 4565 KDTQDIVH----DLESPGIDPSIIKQQVEAAE------------------TIKEETDGLH 4602
++ + + + E ++ K +VE + TI+ E + L
Sbjct: 2339 ENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLT 2398
Query: 4603 EEL--EFIRILGADLIFACGET---EKPEVRKSIDEMNN-AWENLN---KTWKERLEKLE 4653
EL E RI ++I + E EK + + + E ++ A E L K ER+ L
Sbjct: 2399 NELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALH 2458
Query: 4654 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD---------LNTVKDQLNEMKEFK 4704
+ +A + L + + L+ +L G D ++V + E+++ K
Sbjct: 2459 NDQEACKAKEQNLSSQVECLELEKAQLLQ----GLDEAKNNYIVLQSSVNGLIQEVEDGK 2514
Query: 4705 VEVYQQQIEMEKLNH----QGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQH 4760
++ ++ E+ +L + Q +L+ K + E + + +E EL++L L +KI Q
Sbjct: 2515 QKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQS 2574
Query: 4761 K---LEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV 4817
K L+ L L LE + LT +++ ++ K E++ H + +
Sbjct: 2575 KNASLQDTLEVLQSSYKNLENELE-LTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA 2633
Query: 4818 LAHQATVETVNKAGNEL------LESSAGD------DASSLRSRLEAMNQCWESVLQKTE 4865
+ N+ EL ++SS + S L+ L+ M++ K
Sbjct: 2634 ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2693
Query: 4866 EREQQLQSTLQQAQGFHS------------EIEDFLLELTRMESQLSASKPTGGLPETAR 4913
E + Q L +A+ H EI+ + +LT E LS+ K L ++++
Sbjct: 2694 EEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
Query: 4914 EQLDTHMELYSQL-----KAKEET---YNQLLD-----KGRLMLLSRDDSGSGSKTEQSV 4960
E+L+ ++ +Q+ K K + NQL +G++ LL + S + E+
Sbjct: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIK----SCKQLEEEK 2809
Query: 4961 ALLEQKWHVVSSKMEERK------SKLEEALNLATEFQNSLQE 4997
+L+++ + + E++K +K++E E + +L+E
Sbjct: 2810 EILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEE 2852
Score = 41.2 bits (95), Expect = 0.031
Identities = 201/1085 (18%), Positives = 410/1085 (37%), Gaps = 211/1085 (19%)
Query: 4629 KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQ------------------DTLQAMF 4670
+ I E+ + L K ++R +L D+++AA+Q Q L +
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQL-DSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76
Query: 4671 DWLDNTVIKLCTMPPVG-TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT 4729
+ L+ T K+ V + +N + QLN K+ ++E +Q+++ K + ++
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKK-QIEKLEQELKRCKSELERSQQAAQSA 135
Query: 4730 D------ETDRDIIREPLTELKHL----WENLGEKI---AHRQHKLEGALLALGQFQHAL 4776
D T + I PLT ++ +E+L EK + +LE + AL Q + A
Sbjct: 136 DVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL-QAKKAS 194
Query: 4777 EELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKN-------------------DV 4817
+ L + ++ A+ S + E H+ N +V
Sbjct: 195 QTLPQATMNHRDI--ARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV 252
Query: 4818 LAHQATVETVNKAGNELLESSAGDDASS--LRSRLEAMNQCWESVLQKTEEREQQLQSTL 4875
++T++ + N SS D++SS L +L+A NQ + K E E +LQ
Sbjct: 253 TPSRSTLQIGKRDAN----SSFFDNSSSPHLLDQLKAQNQ---ELRNKINELELRLQGHE 305
Query: 4876 QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQ 4935
++ +G ++ ++ L+L + + +L + + R++L Y Q K Q
Sbjct: 306 KEMKGQVNKFQELQLQLEKAKVELIEKEK---VLNKCRDELVRTTAQYDQASTKYTALEQ 362
Query: 4936 LLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK--------------- 4980
L K L+ D S E + LEQK + +E S+
Sbjct: 363 KLKK-----LTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQM 417
Query: 4981 ---------------------LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLIL 5019
L++ ++ + +N+L+EF L AEQ+ + +
Sbjct: 418 KARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS---QIKE 474
Query: 5020 NTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKV 5079
N + +EE K N + +H +Q + + ++ IK L Q+ E++
Sbjct: 475 NELRRSMEEMKKENNLLKSHSEQ--------KAREVCHLEAELKNIKQCLNQSQNFAEEM 526
Query: 5080 VQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISND------------ 5127
++ + L D +++ Q + ++ L+ A + L+ + + S D
Sbjct: 527 KAKNTSQETMLRDLQEKINQQENS--LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 5128 PDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187
DK+ + K L K+ Y+ +EKTL + + L ++ + +
Sbjct: 585 NDKLSKTEKESKALLSALELKKKEYE------ELKEEKTLFSCWKSENEKLLTQMESEKE 638
Query: 5188 TVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDA 5247
+ K + L+ + S ++ + ++ L E E + +H LD ++
Sbjct: 639 NLQSKINHLETCLKTQQIKSHEYNERVRTLE---MDRENLSVEIRNLHNVLDSKSVEVET 695
Query: 5248 HKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR 5307
K+ EL ++ + + ++ IEN T+ + GQ+++L + + + K
Sbjct: 696 QKLAYMELQQK---AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
Query: 5308 LEQALKQAEVFRDTV--------------HMLLEWLSEAEQTLRF------RGALPDDTE 5347
+ + E RD + LL + + F +G++P +
Sbjct: 753 YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812
Query: 5348 ALQSLIDTHKE----FMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARF 5403
+ D + +V+ + S M + C + I+
Sbjct: 813 ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEE---------LVQIKGEI 863
Query: 5404 EEVLTWAKQ-HQ-------QRLETALSELVANAELLEELLAWIQWAETTL------IQRD 5449
EE L A+Q HQ QR+ + A+ ++ E L+ ++ E L ++ +
Sbjct: 864 EENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETE 923
Query: 5450 QEPIPQNIDRVKAL----IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSR 5505
Q I Q + + L + E Q E ++ ++ ++ + KR+ E T K
Sbjct: 924 QAEI-QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEI 982
Query: 5506 SGGRKSLSQPTPPPMPILSQSEA-------KNPRINQLSARWQQVWLLALERQRKLNDAL 5558
+ SL+Q M ++ +SE+ + I++LS +++Q L+ L+R + +A
Sbjct: 983 NA---SLNQ---EKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 5559 DRLEE 5563
+ L +
Sbjct: 1037 EDLSQ 1041
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 170 bits (431), Expect = 3e-41
Identities = 356/1821 (19%), Positives = 719/1821 (39%), Gaps = 163/1821 (8%)
Query: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLS-----------WLADTEEL 3801
+ +IN W L K +R L+ L+ Q+ LE L + WL++ + L
Sbjct: 392 ISDINKAWERLEKAEHERELALRTELIR----QEKLEQLAARFDRKAAMRETWLSENQRL 447
Query: 3802 IANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3861
++ Q E V+A +++ + ++ + V + A +A + D ++I +
Sbjct: 448 VS-QDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELA-AERYHDIKRIAAR 505
Query: 3862 LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQT 3921
++ W L AAR+++L L L K F + + D++ + +L S+ +G
Sbjct: 506 QHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLY-LMDWMEEMKGRL-QSQDLGRHL 563
Query: 3922 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT--------SPAEQGVLSEKIDS 3973
A ++ + H+ +E DI A V S S+L P + ++SE++
Sbjct: 564 AGVEDLLQLHELVEADIAVQAERVRAV-----SASALRFCNPGKEYRPCDPQLVSERVAK 618
Query: 3974 LQARYSEIQDRCCRKAALLDQALSNARLFGE-DEVEVLNWLAEVEDKLSSVFVKDFKQDV 4032
L+ Y + + + A L+++ R E E E W+ E + L+S D +D+
Sbjct: 619 LEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEA--WVREQQHLLASA---DTGRDL 673
Query: 4033 LH--RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI 4090
R H AL E+ R + ++ GQ L+ + + ++ ++ +
Sbjct: 674 TGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGH-PGASQASARAAELQAQWERL 732
Query: 4091 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQ- 4149
+ + + L QA L +FQ+ ++ WL V+ S + E Q RQ
Sbjct: 733 EALAEERAQRLAQAASLY-QFQADANDMEAWL--VDALRLVSSPELGHDEFSTQALARQH 789
Query: 4150 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209
+ L++E+ HR LD + E + AL + R E + V Y+ + G+R
Sbjct: 790 RALEEEIRSHRPTLDALREQAAALPPTLS-RTPE-VQGRVPTLERHYEELQARAGERARA 847
Query: 4210 IDAAIQRSQQYEQAADAELAWVAETKRKLMALG-PIRLEQDQTTAQL-----QVQKAFSI 4263
++AA+ +A L WV E ++ L L P RLE + Q +
Sbjct: 848 LEAALALYTMLSEAGACGL-WVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAA 906
Query: 4264 DIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQ 4323
I D ++L G+++ QE+ QQ+ ++ + A L A
Sbjct: 907 QITAVNDIAEQLLKANPP-----GKDRIVNTQEQLNHRWQQFRRLA---DGKKAALTSAL 958
Query: 4324 VLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDK 4383
+ N E E W+ E +I D + Q ++ + + +
Sbjct: 959 SIQNYHLEC-TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGE 1017
Query: 4384 LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK 4443
L + L +P + + + ++ + + ++ +R+R +E++ ++ ++ +F
Sbjct: 1018 LTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRR----EESLGEARRLQDFLRS 1073
Query: 4444 IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4503
++ L + + PA + + ++ + + E+E+ Q + L+ GEE +
Sbjct: 1074 LDDFQAWLGRTQTAVASEEG-PATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEE-V 1131
Query: 4504 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4563
R Q + L ++ +L+ + WE++ E R+ + + F D
Sbjct: 1132 TRDQADPQCLFLRQ---RLEALGTGWEELGRMWESRQGRLAQAHGF-QGFLRDARQAEGV 1187
Query: 4564 IKDTQDIVHDLESPGI---DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACG 4620
+ + ++ E PG + IK+ + T+ + +H LE R L ++ G
Sbjct: 1188 LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSE-----G 1242
Query: 4621 ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL 4680
++R+ D + + ++ L +L D + QD + W+D K+
Sbjct: 1243 NIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKL-WIDE---KM 1298
Query: 4681 CTMPPVGTD-LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG-ELMLKKATDETDRDIIR 4738
T V D + + + + F E+ + ++K++ +G EL L+K + ++
Sbjct: 1299 LTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA---LVS 1355
Query: 4739 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG 4798
E L +L W+ L + L A A F + L SWL + L +
Sbjct: 1356 EKLRDLHRRWDELETTTQAKARSLFDANRA-ELFAQSCCALESWLESLQAQLHSD-DYGK 1413
Query: 4799 DPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWE 4858
D + + L K +L+ ++ + VE + L + G A + A+ + +
Sbjct: 1414 DLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQG--AGEVERTSRAVEEKFR 1471
Query: 4859 SVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT 4918
++ Q ER ++LQ++ +Q Q FH ++ED +L +T S+ + LP + + +
Sbjct: 1472 ALCQPMRERCRRLQASREQHQ-FHRDVEDEILWVTERLPMASSMEHGKDLP-SVQLLMKK 1529
Query: 4919 HMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4978
+ L +++ E L ++ R + + +A L++ W + ++E R
Sbjct: 1530 NQTLQKEIQGHEPRIADLRERQRAL--------GAAAAGPELAELQEMWKRLGHELELRG 1581
Query: 4979 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN-TVLSQIEEHKVFANEVN 5037
+LE+AL A +F E W+ EQ L++ + +++++H+V +
Sbjct: 1582 KRLEDALR-AQQFYRDAAEAEAWM--GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALA 1638
Query: 5038 AHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
+ I +L + + + + I V + + + + ER L + R
Sbjct: 1639 DYAQTIHQLAASSQDM-IDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQE-HLRL 1696
Query: 5098 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK---TLGGKQPVYDT 5154
Q L W+++ E S E+ D + + + K +EF + T+G ++
Sbjct: 1697 CQLRRELDDLEQWIQEREVVAASH-ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSAN 1755
Query: 5155 TIRTGRAL---KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFM 5211
+ G + + E L+ ++ + DT G+ + ++L+ L
Sbjct: 1756 ALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR-GQVLAAAYELQRFL------H 1808
Query: 5212 DALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRE 5271
A QAL +K + QL + DL+ L H ++ ++ + VQ ++ G
Sbjct: 1809 GARQALARVQHK-QQQLPDG--TGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHR 1865
Query: 5272 LIENSRDDTTWVKGQ-LQELSTRWDTVCKLSVSKQSRLEQALKQAEVFR--DTVHMLLEW 5328
L + D G+ +Q ++ W +L S +R + L + FR V L+ W
Sbjct: 1866 LQKAYAGDKAEEIGRHMQAVAEAW---AQLQGSSAARRQLLLDTTDKFRFFKAVRELMLW 1922
Query: 5329 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 5388
+ E + + P D + +I + ++E + +S + MG+ +LA H
Sbjct: 1923 MDEVNLQMDAQER-PRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSH-YA 1980
Query: 5389 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELV--ANAELLEELLAWIQWAETTLI 5446
I ++ ++AR +E ++ L+ L LV +A + E AW+
Sbjct: 1981 AEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAE---AWL-------- 2029
Query: 5447 QRDQEPIPQN------IDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPF 5500
QEP+ ++ +D V++LI H+ F + + +R K +E
Sbjct: 2030 -CSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWE---ERFCALEKLTALEER---- 2081
Query: 5501 IEKSRSGGRKSLSQPTPPPMP 5521
EK R R+ + PP P
Sbjct: 2082 -EKERKRKREEEERRKQPPAP 2101
Score = 127 bits (319), Expect = 3e-28
Identities = 224/1073 (20%), Positives = 429/1073 (39%), Gaps = 106/1073 (9%)
Query: 4529 WEDIKARAEEREIKFLDVL-------ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4581
WE ++ ERE+ L +LA +F A T + + Q +V ++ G++
Sbjct: 399 WERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-DNFGLEL 457
Query: 4582 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA---W 4638
+ ++ V E I+ + ++ + + A+L ++++ +N W
Sbjct: 458 AAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAEL----AAERYHDIKRIAARQHNVARLW 513
Query: 4639 ENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKD--Q 4696
+ L + R E+L ++ +QD L M DW++ +L + +G L V+D Q
Sbjct: 514 DFLRQMVAARRERLLLNLELQKVFQDLLYLM-DWMEEMKGRLQSQD-LGRHLAGVEDLLQ 571
Query: 4697 LNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIA 4756
L+E+ E + V +++ + K D ++ E + +L+ +E L E A
Sbjct: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
Query: 4757 HRQHKLEGALLALGQFQHALEELMSWLTHTEELL---DAQRPISGDPKVIEVELAKHHVL 4813
R+ +LE + L +F + E +W+ + LL D R ++G +++ KH L
Sbjct: 632 ARRARLEESR-RLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLN----KHTAL 686
Query: 4814 KNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ- 4872
+ ++ ++ + G +L+ + AS +R + WE + EER Q+L
Sbjct: 687 RGEMSGRLGPLKLTLEQGQQLV-AEGHPGASQASARAAELQAQWERLEALAEERAQRLAQ 745
Query: 4873 -STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT-HMELYSQLKAKE 4930
++L Q Q +++E +L++ R+ S P G E + + L H L ++++
Sbjct: 746 AASLYQFQADANDMEAWLVDALRL-----VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Query: 4931 ETYNQLLDKGRLM--LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLA 4988
T + L ++ + LSR G V LE+ + + ++ ER LE AL L
Sbjct: 801 PTLDALREQAAALPPTLSRTPEVQGR-----VPTLERHYEELQARAGERARALEAALALY 855
Query: 4989 TEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQ 5048
T + + W+ EQ LN + P + + + Q + + E+N QI ++
Sbjct: 856 TMLSEAGACGL-WVEEKEQWLNGLALPERLEDLEVVQ-QRFETLEPEMNTLAAQITAVND 913
Query: 5049 TGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA-------KQFH 5101
QL + I N + RW++ R L D +K A + +H
Sbjct: 914 IAEQL-LKANPPGKDRIVNTQEQLNHRWQQF--------RRLADGKKAALTSALSIQNYH 964
Query: 5102 EAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRA 5161
+ W+ + ++S + ND + L L + K G ++ + R G
Sbjct: 965 LECTETQAWMREKTKVIESTQGLGNDLAGV-LALQR-----KLAGTERDLEAIAARVGEL 1018
Query: 5162 LKEKTLL----PEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
+E L P + ++ L EV+ W+ + R+ L EA F+ +L
Sbjct: 1019 TREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ-DFLRSLDDF 1077
Query: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277
WL + + +A ++ L L+ H + E+ + L+ G E+ +
Sbjct: 1078 QAWLGRTQTAVASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQA 1136
Query: 5278 D-DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336
D +++ +L+ L T W+ + ++ S+Q RL QA RD E + +++ +
Sbjct: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA--EGVLSSQEYV 1194
Query: 5337 RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAV--CHPDCITTIKH 5394
+P +A + I ++FM ++ ++ + G +++ H D I
Sbjct: 1195 LSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKI----- 1249
Query: 5395 WITIIRARFEEVLTWAKQHQQRLETALSELVANAEL------LEELLAWIQWAETTLIQR 5448
R + + + K++Q + L L N E EL WI E L +
Sbjct: 1250 -----REKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWID--EKMLTAQ 1302
Query: 5449 DQEPIPQNIDRVKALIAE---HQTFMEEMTRKQPDVDRVTKTYKRKNIEPTH--APFIEK 5503
D + D + L + HQ FM E+ + +D+V K + +E A EK
Sbjct: 1303 DV-----SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK 1357
Query: 5504 SRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLND 5556
R R+ T S +A + S + WL +L+ Q +D
Sbjct: 1358 LRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDD 1410
Score = 120 bits (302), Expect = 3e-26
Identities = 342/1902 (17%), Positives = 732/1902 (38%), Gaps = 224/1902 (11%)
Query: 3236 QQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ----HSGSYE 3291
++++ + EL W++ + + ++ L +Q+QLQ ++ G+ E
Sbjct: 308 EKYESLASELLQWIE-QTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE 366
Query: 3292 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCM-------QK 3344
V++ +S L + + ++ WE L K +R+ L+ + Q
Sbjct: 367 VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL 426
Query: 3345 AQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNS 3404
A ++ W+ + + +S+ L+ +E+++ + +A+ ++ ++ +++
Sbjct: 427 AARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
Query: 3405 AADILINSSEADEDGI--------------------RDEKAGINQNMDAVTEELQAKTGS 3444
A L D I R E+ +N + V ++L
Sbjct: 487 VAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDW 546
Query: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRA-QQEVLQALE 3503
+EEM RL+ +++ + + G + L++ + + +A E++RA L+
Sbjct: 547 MEEMKGRLQS-----QDLGRHLAGVEDLLQLHELV--EADIAVQAERVRAVSASALRFCN 599
Query: 3504 PQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQ 3563
P +Y Q + E + + L + A++ LE +R + L +G+
Sbjct: 600 PGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR-------LWRFLWEVGE 652
Query: 3564 FHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAEC 3623
VRE LA D D GA+ LNK L+ ++
Sbjct: 653 AEAWVREQQHLLASADTGRDLTGALR---------------LLNKHTALRGEMSGRLGPL 697
Query: 3624 RHMLEEEGTLDLLGLKRELEALNK--QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3681
+ LE+ L G +A + + ER +A E+ L + Y+ N
Sbjct: 698 KLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADAN 757
Query: 3682 DATTAAEEAEALQWVVGTEV---EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ 3738
D A +AL+ V E+ E Q LA +E++ + L + L
Sbjct: 758 DME--AWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPP 815
Query: 3739 SAGKDCDVQG----LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLS- 3793
+ + +VQG LE EE+ AR +R L+ AL AL +LS
Sbjct: 816 TLSRTPEVQGRVPTLERHYEELQAR-------AGERARALEAAL--------ALYTMLSE 860
Query: 3794 ------WLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIA 3847
W+ + E+ + P ++++ +++Q+ + + ++ L A+ +
Sbjct: 861 AGACGLWVEEKEQWLNGLALPE--------RLEDLEVVQQRFETLEPEMNTLAAQITAVN 912
Query: 3848 QSAELA------DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPIS 3901
AE +++I E L RW + A ++ L L + + +H
Sbjct: 913 DIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI-QNYHLECTETQ 971
Query: 3902 DFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSP 3961
++ K + +++ +G A + + E D+E A V + + +L++ P
Sbjct: 972 AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA-GHP 1030
Query: 3962 AEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN----WLAEVE 4017
A+ ++ ++ +Q + +++ R+ +++L AR +D + L+ WL +
Sbjct: 1031 AQAVAINARLREVQTGWEDLRATMRRR----EESLGEARRL-QDFLRSLDDFQAWLGRTQ 1085
Query: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ 4077
++S + A H AL E+ + + G+ + + + L ++
Sbjct: 1086 TAVASEEGPATLPEA-EALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLR 1144
Query: 4078 EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSP 4137
++L+ + T + ++ L QA FQ G+LR+ + Q
Sbjct: 1145 QRLEALGTGWEELGRMWESRQGRLAQAHG----FQ-------GFLRDARQAEGVLSSQEY 1193
Query: 4138 --TGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQ 4195
+ ++P Q K++ + +D E LLE +LVS+ N
Sbjct: 1194 VLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGR--------QLVSEGN-- 1243
Query: 4196 YKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRL--EQDQTTA 4253
+ +D I ++ D I+ +++Q Q L E + L ++L ++ TA
Sbjct: 1244 --IHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTA 1301
Query: 4254 Q-------------LQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES 4300
Q Q +AF ++ +KD +D++ E+ E K ++ EK
Sbjct: 1302 QDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLE-KPELKALVSEKLRD 1360
Query: 4301 LIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI--DHE 4358
L ++++ + + L A F ++ L W+E +L AQL S D
Sbjct: 1361 LHRRWDELETTTQAKARSLFDAN-RAELFAQSCCALESWLE---SLQAQLHSDDYGKDLT 1416
Query: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKE 4418
+ ++ + L +A + ++ + L + + GE VE + E + + +
Sbjct: 1417 SVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQ 1475
Query: 4419 EVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDN 4478
+R+R L + Q + D+I + E L SS ++ ++ + N
Sbjct: 1476 PMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEH-----GKDLPSVQLLMKKN 1530
Query: 4479 KSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEE 4538
++ E++ +P L+ R L + G + L ++ W+ + E
Sbjct: 1531 QTLQKEIQGHEPRIADLRERQRALGAAAAGPE-----------LAELQEMWKRLGHELEL 1579
Query: 4539 REIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEET 4598
R + D L A++F+ D A + + Q++ + D + +V+ + +++
Sbjct: 1580 RGKRLEDALR-AQQFYRDAAEAEAWMGE-QELHMMGQEKAKDELSAQAEVKKHQVLEQAL 1637
Query: 4599 DGLHEELEFIRILGADLIFACGETEKPE-VRKSIDE--MNNAWENLNKTWKERLEKLEDA 4655
+ + + D+I + E PE R SI + ++ + L + ER E+L++
Sbjct: 1638 ADYAQTIHQLAASSQDMI----DHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEH 1693
Query: 4656 MQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTV---KDQLNEMKEFKVEVYQQQI 4712
++ Q + L + W+ + + +G D V +D+ E + Q+++
Sbjct: 1694 LRLC-QLRRELDDLEQWIQEREV-VAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERV 1751
Query: 4713 EMEKLNHQGELM---LKKATDETDRDIIREPLTELKHLWENLGEKIA---HRQHKLEGAL 4766
+ G + +AT +D + E +L L + G+ +A Q L GA
Sbjct: 1752 DSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGAR 1811
Query: 4767 LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVET 4826
AL + QH ++L D E +H ++D+ A V+
Sbjct: 1812 QALARVQHKQQQLPDGTGR-------------DLNAAEALQRRHCAYEHDIQALSPQVQQ 1858
Query: 4827 VNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE 4886
V G+ L ++ AGD A + ++A+ + W + + R Q L T + + F +
Sbjct: 1859 VQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFR-FFKAVR 1917
Query: 4887 DFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4946
+ +L + + Q+ A + + +A + + ++++A+ + ++ +D G+ LL+
Sbjct: 1918 ELMLWMDEVNLQMDAQERPRDV-SSADLVIKNQQGIKAEIEARADRFSSCIDMGK-ELLA 1975
Query: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
R + + + ++ L+ + + K +E+ L+ L + F WL ++
Sbjct: 1976 RSHY-AAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLV-FGRDAGMAEAWL-CSQ 2032
Query: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQ 5048
+ L ++ ++ V S I+ H+ F A ++ L++
Sbjct: 2033 EPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEK 2074
Score = 117 bits (293), Expect = 3e-25
Identities = 313/1754 (17%), Positives = 686/1754 (39%), Gaps = 186/1754 (10%)
Query: 2098 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 2157
Q+ ++ A F E ++ ENQ +S + A ++EA++ +
Sbjct: 420 QEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSG 479
Query: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTS-VGSSGGQLLTNLPGME---- 2212
++ A + E+ K +A + + L D++ V + +LL NL +
Sbjct: 480 RVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQD 539
Query: 2213 ---QLSGASLEKGALDTTDGYMGVNQA-PEKLDKQCEMMKARHQELLSQQQNFILATQSA 2268
+ KG L + D +G + A E L + E+++A ++ Q + + SA
Sbjct: 540 LLYLMDWMEEMKGRLQSQD--LGRHLAGVEDLLQLHELVEA---DIAVQAERVRAVSASA 594
Query: 2269 QAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 2328
F + G P + Q++ +++ +L++ Y + A +++ + L +FL + E
Sbjct: 595 LRFCNP-GKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESR-RLWRFLWEVGE 652
Query: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
E+W+ + L + G L LL + + ++ G L+ GQ+++
Sbjct: 653 AEAWVREQQHLLASADTGRDLTGAL-RLLNKHTALRGEMSGRLGPLKLTLEQGQQLV--- 708
Query: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTAL-HSKCTRLGSHLNMLLGQYHQFQNSADSLQ 2447
EG + + +L+ ER AL + RL ++ +QFQ A+ ++
Sbjct: 709 ---AEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASL-----YQFQADANDME 760
Query: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507
AW+ + + S + D Q + L+EE+ H+ ++ L++ A +
Sbjct: 761 AWLVDA---LRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTL 817
Query: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567
VQ ++ H++ L ER+ L+ A+A L ++L G
Sbjct: 818 SRTP----EVQGRVPTLERHYEELQARAGERARALEAALA--------LYTMLSEAGACG 865
Query: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQ 2627
+E K+ L+ + E L ++Q + + +T + A+ A
Sbjct: 866 LWVEEKE-QWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPP 924
Query: 2628 GK------LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2681
GK +++ R++Q K+++L L + + + Q +M K++++ S
Sbjct: 925 GKDRIVNTQEQLNHRWQQFRRLADGKKAALTSAL-SIQNYHLECTETQAWMREKTKVIES 983
Query: 2682 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELS------SCGFALDLCQHQDR 2735
Q + + + L ++ + +L+ + V EL+ + G R
Sbjct: 984 ----TQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINAR 1039
Query: 2736 VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAK 2795
++ ++ + +L+ T++ RE+ + +L +F + + FQ WL T+T+++++
Sbjct: 1040 LREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGR-------TQTAVASE 1091
Query: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855
E + ++LL A+ VE + + L L E+T
Sbjct: 1092 EGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVT------------------- 1132
Query: 2856 GSVNGYHTCKDLTEIQC-----DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEAN 2910
+D + QC + + +E+LG + RQ L A + + ++A
Sbjct: 1133 ---------RDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL-AQAHGFQGFLRDAR 1182
Query: 2911 SVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLL 2970
L S+E VL + P + A + + F++ ++ N +I + E AG
Sbjct: 1183 QAEGVLSSQEYVLSHTE---MPGTLQAADAAIKKLEDFMSTMDANGERIHGLLE--AGRQ 1237
Query: 2971 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 3030
+ + A+ ++ + + R ++ + +L ++ Q +L+ W+ E
Sbjct: 1238 LVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCH-ELKLWIDE 1296
Query: 3031 KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLST 3090
K M+ + L+ + Q+ Q + E A + +++++ + + ++
Sbjct: 1297 K--MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELK--- 1351
Query: 3091 SQVQKELQSINQKWVEL--TDKLNSRS----SQIDQAIVKSTQYQELLQDLSEKVRA--V 3142
+ V ++L+ ++++W EL T + +RS ++ + + L+ L ++ +
Sbjct: 1352 ALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDY 1411
Query: 3143 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
G+ L+ + + + +Q LE +R KE + + + L E E
Sbjct: 1412 GKDLTSVNILLKK----QQMLEWEMAVRE---------KEVEAIQAQAKALAQEDQGAGE 1458
Query: 3203 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 3262
+++ V + L +R RLQA+ Q + + DE+ W+ ++ A +
Sbjct: 1459 VERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEI-LWVTER-LPMASSMEH 1516
Query: 3263 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 3322
L +Q +++N+ QK + H + E + L + G E L EL+
Sbjct: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRI-ADLRERQRALGAAAAGPE-------LAELQE 1568
Query: 3323 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 3382
W+ L + R RL+D + +AQ++ + W+ + + M D + ++ +
Sbjct: 1569 MWKRLGHELELRGKRLEDAL-RAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEV 1627
Query: 3383 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKT 3442
+ + + + + L +++ +I+ + I +A +++ + E +
Sbjct: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERR 1687
Query: 3443 GSLEE---MTQRLREFQESFKNI-EKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEV 3498
L+E + Q RE + + I E++V A H+L D +K E R +
Sbjct: 1688 ERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELG-QDYEHVTMLRDKFREFSRDTSTI 1746
Query: 3499 LQALEPQVDYLRNFTQGLVEDAPDG----SDASQLLHQAEVAQQEFLEVKQRVNSGCVMM 3554
Q +VD GL+ ++ L++A E L+ + +V + +
Sbjct: 1747 GQ---ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYEL 1803
Query: 3555 ENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKL 3614
+ L G Q RV+ QL D GRD ++ ++ + + I L
Sbjct: 1804 QRFLHGARQALARVQHKQQQLPD---------GTGRDLNAAEALQRRHCAYEHDIQALSP 1854
Query: 3615 DIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFY 3674
++ + + + + + R ++A+ + +L AR++ L T + F+
Sbjct: 1855 QVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFR-FF 1913
Query: 3675 RKLKGL----NDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVN 3730
+ ++ L ++ + E + V ++ I NQQ K +++ +
Sbjct: 1914 KAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGI------KAEIEARADRFSSCI 1967
Query: 3731 GLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEAL--LHCGKFQDAL 3788
+G+ L+ A + + + ++ AR +K +++ LQ L L G+
Sbjct: 1968 DMGKELL--ARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMA 2025
Query: 3789 EPLLSWLADTEELI 3802
E +WL E L+
Sbjct: 2026 E---AWLCSQEPLV 2036
Score = 106 bits (265), Expect = 6e-22
Identities = 276/1504 (18%), Positives = 572/1504 (38%), Gaps = 208/1504 (13%)
Query: 4203 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 4262
IG+ +D A + ++YE A L W+ +T ++ L +L + Q Q+Q S
Sbjct: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQT---IVTLNDRQLANSLSGVQNQLQSFNS 349
Query: 4263 IDIIRHKDSMDE-------LFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSER 4315
+ E LF+ +S++ + + + +E + ER
Sbjct: 350 YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHER 409
Query: 4316 -------YARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMR 4368
R E+ + L +F W+ E + L++Q D+ L E+
Sbjct: 410 ELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ------DNFGL-----ELA 458
Query: 4369 QLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENM------YAQIKEEVRQ 4422
+ ++ +H+ ++ +++ ++ E+ E+Y + + A++ + +RQ
Sbjct: 459 AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQ 518
Query: 4423 RALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL---IPAEVDKIRECISDNK 4479
A E + + ++ + + +++ +E + RL+ L + D ++
Sbjct: 519 MVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEA 578
Query: 4480 SATVELEKLQP-SFEALK--RRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARA 4536
V+ E+++ S AL+ G+E + D L ++ + KL+Q +E + A
Sbjct: 579 DIAVQAERVRAVSASALRFCNPGKEY----RPCDPQLVSERVA-KLEQS---YEALCELA 630
Query: 4537 EEREIKFLDVLELAEKFW---YDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAET 4593
R + LE + + W +++ +++ Q ++ ++ G D + + +
Sbjct: 631 AARRAR----LEESRRLWRFLWEVGEAEAWVREQQHLLASADT-GRDLTGALRLLNKHTA 685
Query: 4594 IKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLE 4653
++ E G L+ G L+ A G + E+ WE L +ER ++L
Sbjct: 686 LRGEMSGRLGPLKLTLEQGQQLV-AEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
Query: 4654 DAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIE 4713
A + Q+Q M WL + ++L + P +G D + + + + + E+ +
Sbjct: 745 QA-ASLYQFQADANDMEAWLVD-ALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPT 802
Query: 4714 MEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL------ 4767
++ L Q + + + ++ + L+ +E L + R LE AL
Sbjct: 803 LDALREQAAALPPTLSRTPE---VQGRVPTLERHYEELQARAGERARALEAALALYTMLS 859
Query: 4768 ---ALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATV 4824
A G + E+ ++ L E L D +EV + L+ ++ A +
Sbjct: 860 EAGACGLWVEEKEQWLNGLALPERLED-----------LEVVQQRFETLEPEMNTLAAQI 908
Query: 4825 ETVNKAGNELLESS-AGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFH- 4882
VN +LL+++ G D + + E +N W+ + + ++ L S L Q +H
Sbjct: 909 TAVNDIAEQLLKANPPGKD--RIVNTQEQLNHRWQQFRRLADGKKAALTSAL-SIQNYHL 965
Query: 4883 --SEIEDFLLELTR-MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
+E + ++ E T+ +ES G+ R+ T +L +
Sbjct: 966 ECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEA-------------IA 1012
Query: 4940 GRLMLLSRDDSG-SGSKTEQSVAL------LEQKWHVVSSKMEERKSKLEEALNLATEFQ 4992
R+ L+R+ + + Q+VA+ ++ W + + M R+ L EA L +F
Sbjct: 1013 ARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRL-QDFL 1071
Query: 4993 NSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQ 5052
SL +F WL + ++ P+ L + + +H EV + + L G +
Sbjct: 1072 RSLDDFQAWLGRTQTAVASEEGPA-TLPEAEALLAQHAALRGEVERAQSEYSRLRALGEE 1130
Query: 5053 LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLE 5112
+ + ++ L ++ + WE E GR + + R Q H L D +
Sbjct: 1131 VTRDQADPQCLFLRQRLEALGTGWE-------ELGRMWESRQGRLAQAHGFQGFLRDARQ 1183
Query: 5113 -----DAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 5167
++ ++ S E+ + K ++F T+ + GR L +
Sbjct: 1184 AEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGN 1243
Query: 5168 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEE--ALLFSGQFMD------ALQALVD 5219
+ D ++R+K D S+ER+HK + A F G+ D LQ +
Sbjct: 1244 IHAD---------KIREKAD-----SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHE 1289
Query: 5220 WLYKVEPQLAEDQPVHGDLDLVMNL---MDAHKVFQKELGKRTGTVQVLKRSGRELIENS 5276
++ ++ Q V D NL H+ F EL + + + GREL
Sbjct: 1290 LKLWIDEKMLTAQDV--SYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK 1347
Query: 5277 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336
+ V +L++L RWD + + +K L A +AE+F + L WL E+ Q
Sbjct: 1348 PELKALVSEKLRDLHRRWDELETTTQAKARSLFDA-NRAELFAQSCCALESWL-ESLQAQ 1405
Query: 5337 RFRGALPDDTEALQSLIDTHK--EFMKKVEEKRVDVNSAVAMGEVILAVCHPD-CITTIK 5393
D ++ L+ + E+ V EK V+ A A A+ D ++
Sbjct: 1406 LHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAK-----ALAQEDQGAGEVE 1460
Query: 5394 HWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI 5453
+ +F + ++ +RL+ + + + ++ +E+L W L
Sbjct: 1461 RTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEIL----WVTERLPMASSMEH 1516
Query: 5454 PQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLS 5513
+++ V+ L+ ++QT +E+ + EP A E+ R+ G
Sbjct: 1517 GKDLPSVQLLMKKNQTLQKEI----------------QGHEPRIADLRERQRALG----- 1555
Query: 5514 QPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFD 5573
+ A P + +L W+++ R ++L DAL + ++ A +
Sbjct: 1556 ------------AAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE-- 1601
Query: 5574 VWRKKYMRWMNHKKSRVMDFFRRIDK-DQDGKITRQEFIDGILASKFPTTKLEMTAVADI 5632
WM ++ +M + D+ ++ + + ++ LA T + D+
Sbjct: 1602 -------AWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDM 1654
Query: 5633 FDRD 5636
D +
Sbjct: 1655 IDHE 1658
Score = 98.6 bits (244), Expect = 2e-19
Identities = 327/1745 (18%), Positives = 668/1745 (38%), Gaps = 199/1745 (11%)
Query: 2874 MSDVNLKYEKLGGVLHERQESLQAILNRMEEVH-------KEANSVLQWLESKEEVLKSM 2926
+SD+N +E+L HER+ +L+ L R E++ ++A WL S+ + L S
Sbjct: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWL-SENQRLVSQ 450
Query: 2927 DAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI- 2985
D + V+A ++A ++ S ++Q V A L ++ + K+I
Sbjct: 451 DNFG--LELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELA-----AERYHDIKRIA 503
Query: 2986 --QEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043
Q + W+ ++ AR+ +L + FQ L W+ E M G L +
Sbjct: 504 ARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDL-LYLMDWMEE---MKGRLQSQDL 559
Query: 3044 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGI-LTGPG------DVSLSTSQVQK- 3095
++ + L E + Q +A + PG D L + +V K
Sbjct: 560 GRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKL 619
Query: 3096 --------ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELL------QDLSEKVRA 3141
EL + + +E + +L ++ +A + Q LL +DL+ +R
Sbjct: 620 EQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRL 679
Query: 3142 VGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD 3201
+ + +++ +S + +K LE+ ++ V E + S
Sbjct: 680 LNKHTALRGEMSGRLGPLKLTLEQGQQL----------VAEGHPGASQASA--------- 720
Query: 3202 ELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCP 3261
R + + LE LA +R RL A AS QFQ +++ WL D + +
Sbjct: 721 ----RAAELQAQWERLEALAEERAQRL-AQAASLYQFQADANDMEAWLVD-ALRLVSSPE 774
Query: 3262 ISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELK 3321
+ Q+ +++ ++ + H + + + + +L P +Q ++ L+
Sbjct: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL---PPTLSRTPEVQGRVPTLE 831
Query: 3322 NHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESS 3381
H+EEL + +R L+ + W+E+ + ++ L + LE
Sbjct: 832 RHYEELQARAGERARALEAALALYTMLS-EAGACGLWVEEKEQWLNGLALPERLEDLEVV 890
Query: 3382 LLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 3441
R + + E+ + + +N A+ L+ ++ +D I + + +N K
Sbjct: 891 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGK 950
Query: 3442 TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE-KLRAQQEVLQ 3500
+L ++ + + + +E LG+ L+ KL + L+
Sbjct: 951 KAALTSALS-IQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLE 1009
Query: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560
A+ +V L L P QA EV+ M + E
Sbjct: 1010 AIAARVGELTREANALAAGHP---------AQAVAINARLREVQTGWEDLRATMRRREES 1060
Query: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ-----IEDVRLFLNKIHVLKLD 3615
+G+ R + L LD D +GR ++ S+ + + L + L+ +
Sbjct: 1061 LGE----ARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGE 1113
Query: 3616 IEASEAECRHM--LEEEGTLD-----LLGLKRELEALNKQCGKLTERGKARQEQLELTLG 3668
+E +++E + L EE T D L L++ LEAL +L ++RQ G
Sbjct: 1114 VERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQ-------G 1166
Query: 3669 RVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQ-VDPLQMKLQ 3727
R+ + L DA A + ++V+ Q AD + + E + + +
Sbjct: 1167 RLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGE 1226
Query: 3728 QVNGL---GQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3784
+++GL G+ L+ D + + I R Q + +L++
Sbjct: 1227 RIHGLLEAGRQLVSEGNIHAD--KIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFL 1284
Query: 3785 QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGG 3844
QD E L W+ E+++ Q E + + + Q+ + L K +D + EG
Sbjct: 1285 QDCHE-LKLWI--DEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGR 1341
Query: 3845 RIA-QSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
+ + EL + ++ +L L RW EL + A+ + L D A+ F ++ + +
Sbjct: 1342 ELTLEKPEL--KALVSEKLRDLHRRWDELETTTQAKARSLFD-ANRAELFAQSCCALESW 1398
Query: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3963
L + +L +S+ G + + + + LE ++ +V ++L+ A
Sbjct: 1399 LESLQAQL-HSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAG 1457
Query: 3964 QGVLSEKI--DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLS 4021
+ + + + +A +++RC R A +Q F D + + W+ E S
Sbjct: 1458 EVERTSRAVEEKFRALCQPMRERCRRLQASREQ-----HQFHRDVEDEILWVTERLPMAS 1512
Query: 4022 SV-FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 4080
S+ KD L + + L +EI + + + +AL G E+ +QE
Sbjct: 1513 SMEHGKDLPSVQLLMK--KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-- 1568
Query: 4081 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE 4140
+ R K L +A+Q F E W+ E E + GQ +
Sbjct: 1569 --MWKRLGHELELRGKRLEDALRAQQ----FYRDAAEAEAWMGEQELHMM---GQEKAKD 1619
Query: 4141 QIPQFQQRQKELKK-EVMEHRLV--LDTVNEVSRALLELVPWRAREGLDKLVSDA--NEQ 4195
++ Q E+KK +V+E L T+++++ + +++ E + A ++
Sbjct: 1620 EL----SAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKL 1675
Query: 4196 YKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL 4255
Y + + G+R + + ++ Q + D E W+ E + + A + + + T
Sbjct: 1676 YAGLKELAGERRERLQEHLRLCQLRRELDDLE-QWIQE-REVVAASHELGQDYEHVTMLR 1733
Query: 4256 QVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY-EAISLLNSE 4314
+ FS D + + + G + + E +SL + + + + LL++
Sbjct: 1734 DKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDT- 1792
Query: 4315 RYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESI 4374
R QVL + EL ++ R +A+ + H+Q + R L +
Sbjct: 1793 ------RGQVLAAAY-----ELQRFLHGARQALAR-----VQHKQQQLPDGTGRDLNAAE 1836
Query: 4375 AEHKPHI---DKLLKIGPQLKELNPEEGEMVEEKY--QKAENM------YAQIKEEVRQR 4423
A + H + + PQ++++ ++G +++ Y KAE + A+ +++
Sbjct: 1837 ALQRRHCAYEHDIQALSPQVQQVQ-DDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGS 1895
Query: 4424 ALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATV 4483
+ A + + +T F + ++ ++ ++ ++ P +V I + +
Sbjct: 1896 SAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQER-PRDVSSADLVIKNQQGIKA 1954
Query: 4484 ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKF 4543
E+E F + G+EL+ RS AA+EI +KL Q ++AR +E K+
Sbjct: 1955 EIEARADRFSSCIDMGKELLARSH-----YAAEEISEKLSQ-------LQARRQETAEKW 2002
Query: 4544 LDVLE 4548
+ ++
Sbjct: 2003 QEKMD 2007
Score = 94.0 bits (232), Expect = 4e-18
Identities = 241/1292 (18%), Positives = 479/1292 (37%), Gaps = 225/1292 (17%)
Query: 1875 EVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDL 1934
EV Q + LE + L +++V+D L A K +++N QL R Q
Sbjct: 888 EVVQQRFETLEPEMNTLAAQITAVNDIAEQLL----KANPPGKDRIVNTQEQLNHRWQQF 943
Query: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEH 1994
R K L S + + + +L + + + + L D+ ++
Sbjct: 944 RRLADGKKAALTSA-----LSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQ 998
Query: 1995 AQDLSPQQNRQMLRL-LNELQRSFQDILEQTAAQVDALQGHLQQMEQ--EALVKTLQKQQ 2051
+ +++ + + + EL R + AQ A+ L++++ E L T+++++
Sbjct: 999 RKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRRE 1058
Query: 2052 NTCHQ---------QLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ 2102
+ + L+D +W+G+ + A+A +G T + AL + L+ + Q
Sbjct: 1059 ESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQ 1118
Query: 2103 NRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQ------ 2156
+ + + +++ + Q + L AL + +E+ Q A
Sbjct: 1119 SEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFL 1178
Query: 2157 --KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQL 2214
E V S+ + ++ L I L D+++++ ++G E++
Sbjct: 1179 RDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANG----------ERI 1228
Query: 2215 SGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 2274
G LE G ++G + ++ EK D ++ RH++
Sbjct: 1229 HGL-LEAGRQLVSEGNIHADKIREKADS----IERRHKK--------------------- 1262
Query: 2275 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLE 2334
Q QQ LG L++ E Q FLQD E + W++
Sbjct: 1263 --------NQDAAQQFLGRLRDNR-------------------EQQHFLQDCHELKLWID 1295
Query: 2335 RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEG 2394
EK L L + ++ +F ++ ++K L V G+++
Sbjct: 1296 --EKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELT--------- 1344
Query: 2395 KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE 2454
E E+ LV +KL+D R+ L + T+ + + F S +L++W+++ +
Sbjct: 1345 LEKPELKALVSEKLRDLHRRWDELETT-TQAKARSLFDANRAELFAQSCCALESWLESLQ 1403
Query: 2455 ANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH 2514
A +L SD D + L + L+ E+A + VE +Q A+ + + E + A +
Sbjct: 1404 A---QLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQ-EDQGAGE- 1458
Query: 2515 RHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQ 2574
V+ T+ ++ F++L + ER LQ + Q Q ++ + +L V + L
Sbjct: 1459 --VERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILW----VTERLP--M 1510
Query: 2575 VSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVS 2634
SS+ G ++ MK Q + ++ ++ + E + AA +LAE+
Sbjct: 1511 ASSMEHGKDLPSVQLLMKKNQTLQKE---IQGHEPRIADLRERQRALGAAAAGPELAELQ 1567
Query: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM-ENKSRMLASGNQPD------- 2686
+ +++L + + + L+ L +A+ F + + + +M E + M+ D
Sbjct: 1568 EMWKRLGHELELRGKRLEDAL-RAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAE 1626
Query: 2687 --------QDITHFFQQIQELNLEMED--------------QQENLDTLEHLVTELSSCG 2724
Q + + Q I +L +D +Q +D L + EL+ G
Sbjct: 1627 VKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELA--G 1684
Query: 2725 FALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2784
+ Q R+ LR++ +L++ ++ERE A+S
Sbjct: 1685 ERRERLQEHLRLCQLRRELDDLEQWIQEREVVAAS------------------------- 1719
Query: 2785 IPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKT 2844
EL + EH+ L D + I + N +
Sbjct: 1720 ----------HELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALAN---------- 1759
Query: 2845 GSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEE 2904
G + G H + D +N + L +L R + L A
Sbjct: 1760 -----------GLIAGGHAARATVAEWKD--SLNEAWADLLELLDTRGQVLAAAYELQRF 1806
Query: 2905 VHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKE 2964
+H A L ++ K++ L + +A + A+ +++ SP++Q+V++
Sbjct: 1807 LH-GARQALARVQHKQQQLPD----GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQD 1861
Query: 2965 ALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQL 3024
L Y +AE + + + W + + AR++ L ++ F+A +L
Sbjct: 1862 DGHRLQKAYA-GDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVR-EL 1919
Query: 3025 RPWLMEKELMMGVL-GPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-- 3081
W+ E L M P + L + Q Q + E EAR + + + +L
Sbjct: 1920 MLWMDEVNLQMDAQERPRDVSSADLVIKNQ--QGIKAEIEARADRFSSCIDMGKELLARS 1977
Query: 3082 --GPGDVSLSTSQVQKELQSINQKWVELTDKL 3111
++S SQ+Q Q +KW E D L
Sbjct: 1978 HYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
Score = 74.7 bits (182), Expect = 3e-12
Identities = 270/1447 (18%), Positives = 551/1447 (38%), Gaps = 211/1447 (14%)
Query: 1926 QLEGRLQDLRAW-VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA 1984
Q + D+ AW V L+ + + + E +L +Q+ L++ + + LDAL
Sbjct: 751 QFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL---ARQHRALEEEIRSHRPTLDALR 807
Query: 1985 FDIQFFISEHAQDLSPQQNR--QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA 2042
E A L P +R ++ + L+R ++++ + + AL+ L
Sbjct: 808 --------EQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALA------ 853
Query: 2043 LVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ 2102
+ T+ + C +E+ W+ G + L L+ Q + L+ ++
Sbjct: 854 -LYTMLSEAGACGLWVEEKEQWLN----------GLALPERLEDLEVVQQRFETLEPEMN 902
Query: 2103 NRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEA 2162
A T V DI E K +P ++++ +EQ ++ R + A
Sbjct: 903 TLAAQI-TAVNDIA----EQLLKANPPG----KDRIVNTQEQLNHRWQQFRRLADGKKAA 953
Query: 2163 VTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222
+TSAL + + + A ++K + S G L L +L+G
Sbjct: 954 LTSALSIQNYHLECTETQAWMREKTKV----IESTQGLGNDLAGVLALQRKLAGT----- 1004
Query: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282
++ E + AR EL T+ A A H P
Sbjct: 1005 ------------------ERDLEAIAARVGEL----------TREANALAAGH-----PA 1031
Query: 2283 EQQMLQQKLGELK---EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKE 2339
+ + +L E++ E ++ + E L + + LQD FL+ +F++WL R++
Sbjct: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEARRLQD----FLRSLDDFQAWLGRTQTA 1087
Query: 2340 LENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSE 2399
+ + + PE +LL + + +V + + + G++V ++ +P
Sbjct: 1088 VASEEGPATLPEA-EALLAQHAALRGEVERAQSEYSRLRALGEEVT------RDQADPQC 1140
Query: 2400 IGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN-SADSLQAWMQACEANVE 2458
+ L+ E + R+ L Q H FQ D+ QA + ++ E
Sbjct: 1141 L------FLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA--EGVLSSQE 1192
Query: 2459 KLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ 2518
+LS T PG LQ A K+L++ ++ E++ + ++ E ++
Sbjct: 1193 YVLSHT--EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Query: 2519 ETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSL 2578
E DSI + + + L+ Q +Q+ E L E+ L + VS
Sbjct: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWI---DEKMLTAQDVSYD 1307
Query: 2579 SSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE 2638
+ + + ++A K L+ + R + A++ KL ++ +R++
Sbjct: 1308 EARNLHTKWQKHQAFMAELAANKDWLDKV-DKEGRELTLEKPELKALVSEKLRDLHRRWD 1366
Query: 2639 QLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITH---FFQQ 2695
+L Q K SL +AE+F L+ ++E+ L S + +D+T ++
Sbjct: 1367 ELETTTQAKARSLFD-ANRAELFAQSCCALESWLESLQAQLHSDDY-GKDLTSVNILLKK 1424
Query: 2696 IQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2755
Q L EM +++ ++ ++ L+ + R + + F L + ++ER +
Sbjct: 1425 QQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRA--VEEKFRALCQPMRERCR 1482
Query: 2756 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKG 2815
+ +EQ +F + V W+ E P +SM E K + ++ L+
Sbjct: 1483 RLQASREQ-HQFHRDVEDEILWVTER----LPMASSM---EHGKDLPSVQLLM---KKNQ 1531
Query: 2816 TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMS 2875
TL +EI + +L + Q G+ ++ G +++
Sbjct: 1532 TLQKEIQGHEPRIADL------RERQRALGA------AAAGP---------------ELA 1564
Query: 2876 DVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKT 2935
++ +++LG L R + L+ L R ++ +++A W+ +E + M
Sbjct: 1565 ELQEMWKRLGHELELRGKRLEDAL-RAQQFYRDAAEAEAWMGEQE-----LHMMGQEKAK 1618
Query: 2936 ETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKI--QEELNSRW 2993
+ + AQAE K + LEQ + LA + + E+ + Q +++ +
Sbjct: 1619 DELSAQAEVKKHQV--LEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLY 1676
Query: 2994 ERATEVTVARQRQLEESASHLACFQAAE--SQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 3051
E+ R+ +L+E HL Q L W+ E+E ++ L D +
Sbjct: 1677 AGLKELAGERRERLQE---HLRLCQLRRELDDLEQWIQERE-VVAASHELGQDYEHVTML 1732
Query: 3052 KQQVQFMLKEFEARRQQH-EQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDK 3110
+ + + ++ Q+ + N A G++ G G + +T K+ S+N+ W +L +
Sbjct: 1733 RDKFREFSRDTSTIGQERVDSANALANGLIAG-GHAARATVAEWKD--SLNEAWADLLEL 1789
Query: 3111 LNSRSSQIDQAIVKSTQYQELLQDLSEKV-RAVGQRLSVQSAISTQPEAVKQQLEETSEI 3169
L++R Q + + + Q L + + R ++ + A +
Sbjct: 1790 LDTRG----QVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAY 1845
Query: 3170 RSDLEQLDHEVKEAQTLCDEL-SVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRL 3228
D++ L +V++ Q L G++ +E+ + ++ VA + L R
Sbjct: 1846 EHDIQALSPQVQQVQDDGHRLQKAYAGDK--AEEIGRHMQAVA---EAWAQLQGSSAARR 1900
Query: 3229 QAALASTQQFQ--QMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQH 3286
Q L +T +F+ + EL W+D+ Q Q + ++ +
Sbjct: 1901 QLLLDTTDKFRFFKAVRELMLWMDEVNLQM-----------DAQERPRDVSSADLVIKNQ 1949
Query: 3287 SGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHW--EELSKKTADRQSRLKDCMQK 3344
G I A + + G+E + ++H+ EE+S+K + Q+R ++ +K
Sbjct: 1950 QGIKAEIEARADRFSSCIDMGKE--------LLARSHYAAEEISEKLSQLQARRQETAEK 2001
Query: 3345 AQ-KYQW 3350
Q K W
Sbjct: 2002 WQEKMDW 2008
Score = 64.7 bits (156), Expect = 3e-09
Identities = 137/729 (18%), Positives = 286/729 (39%), Gaps = 93/729 (12%)
Query: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKME------ERKSKL----EEALNLAT 4989
G LL +D E+S+ ++ SKM+ +R K+ EA L
Sbjct: 249 GLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVE 308
Query: 4990 EFQNSLQEFINWLTLAEQSLN---IASPPSLILNTVLS-----QIEEHKVFANEVNAHRD 5041
++++ E + W+ +LN +A+ S + N + S +E+ F + N
Sbjct: 309 KYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLE-- 366
Query: 5042 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL-------DDAR 5094
+ L ++L+ +QK L+ + WE++ + ER +L +
Sbjct: 367 --VLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLE 424
Query: 5095 KRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDT 5154
+ A +F WL + + L S+ + ++ + KH+ + + Y
Sbjct: 425 QLAARFDRKAAMRETWLSENQ-RLVSQDNFGLELAAVEAAVRKHEAIETDI----VAYSG 479
Query: 5155 TIRTGRALKEKTLLPE--DSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMD 5212
++ A+ + D +++ V WD + R+ +L L F D
Sbjct: 480 RVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQD 539
Query: 5213 ALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGREL 5272
L L+DW+ +++ +L + Q + L V +L+ H++ + ++ + V+ + S
Sbjct: 540 LLY-LMDWMEEMKGRL-QSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRF 597
Query: 5273 IENSRD----DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 5328
++ D V ++ +L ++ +C+L+ ++++RLE++ ++ F V W
Sbjct: 598 CNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEES-RRLWRFLWEVGEAEAW 656
Query: 5329 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 5388
+ E + L D T AL+ L++ H ++ + + + G+ ++A HP
Sbjct: 657 VREQQHLLASADTGRDLTGALR-LLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA 715
Query: 5389 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALS--ELVANAELLEELLAWIQWAETTLI 5446
+ ++A++E + A++ QRL A S + A+A +E W L
Sbjct: 716 -SQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDME------AWLVDALR 768
Query: 5447 QRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRS 5506
+ + +AL +H+ EE+ +P +D
Sbjct: 769 LVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLD------------------------ 804
Query: 5507 GGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566
+L + P LS++ R+ L ++++ A ER R L AL L E
Sbjct: 805 ----ALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSE 860
Query: 5567 FANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM 5626
+W ++ +W+N ++ +D ++ +Q F L + T ++
Sbjct: 861 AG--ACGLWVEEKEQWLNG--------LALPERLEDLEVVQQRF--ETLEPEMNTLAAQI 908
Query: 5627 TAVADIFDR 5635
TAV DI ++
Sbjct: 909 TAVNDIAEQ 917
Score = 39.7 bits (91), Expect = 0.090
Identities = 134/650 (20%), Positives = 234/650 (36%), Gaps = 127/650 (19%)
Query: 1804 LEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELE 1863
+EH + L S L++ + K+IQ E +A+L+ ER+ EL
Sbjct: 1514 MEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR---------ERQRALGAAAAGPEL- 1563
Query: 1864 CVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQ 1923
++ QE+ +L LE K L+ +L + +++A E E
Sbjct: 1564 -------AELQEMWKRLGHELELRGKRLEDALRAQQ--------FYRDAAEAE------- 1601
Query: 1924 HTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDAL 1983
AW+G + L+ G D S +++++ L+Q +A+ + L
Sbjct: 1602 ------------AWMGEQE--LHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQL 1647
Query: 1984 AFDIQFFIS-EHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA 2042
A Q I EH P+ R +R AQVD L L+++ E
Sbjct: 1648 AASSQDMIDHEH-----PESTRISIR----------------QAQVDKLYAGLKELAGER 1686
Query: 2043 LVKTLQKQQNTC--HQQLEDLCSWVGQAERALAGHQ-GRTTQQDLSALQKNQSDLKDLQD 2099
+ LQ+ C ++L+DL W+ + E A H+ G+ + K + +D
Sbjct: 1687 R-ERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTST 1745
Query: 2100 DIQNRATSFATVVKDI------------EGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
Q R S + + E N+ EL R ++ A + +
Sbjct: 1746 IGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQR 1805
Query: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN----KKKIDALLDWVTSVGSSGGQ 2203
R A ++ AA+ L + I AL V V G +
Sbjct: 1806 FLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHR 1865
Query: 2204 LLTNLPG----------------MEQLSGASLEKG--ALDTTDGY----------MGVNQ 2235
L G QL G+S + LDTTD + + +++
Sbjct: 1866 LQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Query: 2236 APEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK 2295
++D Q +L+ + Q I A A+A ++ E E+
Sbjct: 1926 VNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEIS 1985
Query: 2296 EQYSTSLAQSEAELKQVQTLQDELQKFLQ------DHKEFESWLERSEKELENMHKGGSS 2349
E+ S A+ + ++ Q D LQ L+ D E+WL S++ L + G +
Sbjct: 1986 EKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWL-CSQEPLVRSAELGCT 2044
Query: 2350 PETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSE 2399
+ + SL+KR +F + ++ + RF + +K+ +E KE K E
Sbjct: 2045 VDEVESLIKRHEAFQKSAVA--WEERFCAL--EKLTALEEREKERKRKRE 2090
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 205,986,618
Number of Sequences: 37866
Number of extensions: 9111050
Number of successful extensions: 63692
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 205
Number of HSP's successfully gapped in prelim test: 1273
Number of HSP's that attempted gapping in prelim test: 32846
Number of HSP's gapped (non-prelim): 15395
length of query: 5938
length of database: 18,247,518
effective HSP length: 125
effective length of query: 5813
effective length of database: 13,514,268
effective search space: 78558439884
effective search space used: 78558439884
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 74 (33.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.